Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link


Centers for Disease Control and Prevention. CDC twenty four seven. Saving Lives, Protecting People
					Search
		×
			NIOSH
			NIOSH
				All CDC
				Submit
			For a full list of topics:A-Z Index
			Advanced Search
		Advanced Search


The National Institute for Occupational Safety and Health (NIOSH)


Facebook
        Twitter
        LinkedIn
        Syndicate





o-Methylcyclohexanone																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 583–60–8
**NIOSH REL:** 50 ppm (230 mg/m3) TWA, 75 ppm 345 mg/m3) STEL [skin]
**Current OSHA PEL:** 100 ppm (460 mg/m3) TWA [skin]
**1989 OSHA PEL:** 50 ppm (230 mg/m3) TWA, 75 ppm (345 mg/m3) STEL [skin]
**1993-1994 ACGIH TLV:** 50 ppm (229 mg/m3) TWA, 75 ppm (344 mg/m3) STEL [skin]
**Description of substance:** Colorless liquid with a weak, peppermint-like odor.
**LEL:**. . . Unknown
**Original (SCP) IDLH:** 2,500 ppm
**Basis for original (SCP) IDLH:** The chosen IDLH is based on the statement by Patty [1963] that rabbits and cats exhibited sleepiness, respiratory irregularities, and poor coordination after a 1-hour exposure to 2,500 ppm; a 30-minute exposure to 3,500 ppm caused prostration in mice, guinea pigs, and rats [Gross as cited by Lehmann and Flury 1943].
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA:**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50** **(ppm)**
    **LCLo** **(ppm)**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived value**Rat
    Smyth et al. 1969
    2,800
    -----
    4 hr
    5,600 ppm (2.0)
    560 ppm**Lethal dose data:**
 
 **Species**
    **Reference**
    **Route**
    **LD50** **(mg/kg)**
    **LDLo** **(mg/kg)**
    **Adjusted LD**
    **Derived value**Rat
    Smyth et al. 1969
    oral
    2,140
    -----
    3,215 ppm
    322 ppmRabbit
    Treon et al. 1943
    oral
    -----
    1,000-1,250
    1,502-1,878 ppm
    150-188 ppm**Other animal data:** Mice, guinea pigs, and rats exposed at 3,500 ppm for 30 minutes suffered irritation of the mucous membranes and exhibited signs of central nervous system depression [Clayton and Clayton 1981]. Rabbits and cats exhibited sleepiness, respiratory irregularities, and poor coordination after a 1-hour exposure to 2,500 ppm [Clayton and Clayton 1981].
 **Human data:** None relevant for use in determining the revised IDLH.
 
 **Revised IDLH:** 600 ppm **Basis for revised IDLH:** The revised IDLH for o-methylcyclohexanone is 600 ppm based on acute inhalation toxicity data in animals [Smyth et al. 1969]. This may be a conservative value due to the lack of relevant acute inhalation toxicity data for workers.**REFERENCES:**
1. Clayton GD, Clayton FE, eds. [1981]. Patty’s industrial hygiene and toxicology. 3rd rev. ed. Vol. 2C. Toxicology. New York, NY: John Wiley & Sons, Inc., pp. 4722-4723, 4782-4784.
2. Gross E [?]. Unpublished. [From Lehmann KB, Flury F, eds. [1943]. Toxicology and hygiene of industrial solvents. Translated by E. King and H.F. Smyth, Jr. Baltimore, MD: Williams & Wilkins Company, p. 247.]
3. Lehmann KB, Flury F, eds. [1943]. Toxicology and hygiene of industrial solvents. Translated by E. King and H.F. Smyth, Jr. Baltimore, MD: Williams & Wilkins Company, p. 247.
4. Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 1770.
5. Smyth HF Jr, Carpenter CP, Weil CS, Pozzani UC, Striegel JA, Nycum JS [1969]. Range-finding toxicity data: list VII. Am Ind Hyg Assoc J *30*(5):470-476.
6. Treon JF, Crutchfield WE Jr, Kitzmiller KV [1943]. The physiological response of rabbits to cyclohexane, methylcyclohexane, and certain derivatives of these compounds. I. Oral administration and cutaneous application. J Ind Hyg Toxicol *25*(6):199-214.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
Pinterest
Twitter
YouTube
 NIOSH Homepage NIOSH A-Z
Workplace Safety & Health Topics
Publications and Products
Programs
Contact NIOSH


About CDC
					Contact Us
					800-232-4636
 Facebook Twitter Instagram LinkedIn Youtube Pinterest Snapchat
 CONTACT CDC
				Contact Us
							Call 800-232-4636
							Email Us
			ABOUT CDC
				About CDC
							Jobs
							Funding
			POLICIES
				Accessibility
							External Links
							Privacy
							Policies
							No Fear Act
							FOIA
							OIG
							Nondiscrimination
							Vulnerability Disclosure Policy
			CONNECT WITH US
				Facebook
								Twitter
								Instagram
								LinkedIn
							Youtube
								Pinterest
								Snapchat
								Email
			LANGUAGES
				Español
							繁體中文
							Tiếng Việt
							한국어
							Tagalog
							Русский
							العربية
							Kreyòl Ayisyen
							Français
							Polski
							Português
							Italiano
							Deutsch
							日本語
							فارسی
							English


U.S. Department of Health & Human Services
			Accessibility
			External Links
			Privacy
			Policies
			No Fear Act
			FOIA
			Nondiscrimination
			OIG
			Vulnerability Disclosure Policy
			USA.gov


Exit Notification/Disclaimer Policy Close
 Links with this icon  indicate that you are leaving the CDC website. The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website.
					Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website.
					You will be subject to the destination website's privacy policy when you follow the link.
					CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website. Website Disclaimers
 Cancel Continue