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Perchloromethyl mercaptan																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 594–42–3
**NIOSH REL:** 0.1 ppm (0.8 mg/m3) TWA
**Current OSHA PEL:** 0.1 ppm (0.8 mg/m3) TWA
**1989 OSHA PEL:** Same as current PEL
**1993-1994 ACGIH TLV:** 0.1 ppm (0.76 mg/m3) TWA
**Description of substance:** Pale-yellow, oily liquid with an unbearable, acrid odor.
**LEL:** . . Noncombustible Liquid
**Original (SCP) IDLH:** 10 ppm
**Basis for original (SCP) IDLH:** No useful data on acute inhalation toxicity are available on which to base the IDLH for perchloromethyl mercaptan. The chosen IDLH, therefore, has been based on an analogy with hydrogen sulfide. According to ACGIH, perchloromethyl mercaptan is about 20 times more toxic than hydrogen sulfide which has an IDLH of 300 ppm.
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA:**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50** **(ppm)**
    **LCLo** **(ppm)**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived value**Rat RatMouseHumanMouseMouseRat
    Althoff 1973 Althoff 1973Althoff 1973Flury &Zernik 1931Izmerov et al. 1982Marhold 1972Vernot et al. 1977
    11 169-----38-----11
    ----- ----------388-----46-----
    1 hr 1 hr3 hr10 min2 hr15 min1 hr
    14 ppm (1.25) 20 ppm (1.25)16 ppm (1.8)268 ppm (0.69)61 ppm (1.6)36 ppm (0.79)14 ppm (1.25)
    1.4 ppm 2.0 ppm1.6 ppm27 ppm6.1 ppm3.6 ppm1.4 ppm**Lethal dose data:**
 
 **Species**
    **Reference**
    **Route**
    **LD50** **(mg/kg)**
    **LDLo** **(mg/kg)**
    **Adjusted LD**
    **Derived value**Rat
    Marhold 1972
    oral
    82.6
    -----
    75 ppm
    7.5 ppm**Other human data:** It has been stated that perchloromethyl mercaptan is about one-sixth as toxic as phosgene [Prentiss 1937].
 
 **Revised IDLH:** 10 ppm [Unchanged] **Basis for revised IDLH:** Based on acute inhalation toxicity data in humans [Flury and Zernik 1931], a value of about 25 ppm would have been appropriate for perchloromethyl mercaptan. However, the original IDLH for perchloromethyl mercaptan (10 ppm) is not being revised at this time based on an analogy to phosgene [Prentiss 1937] which has a revised IDLH of 2 ppm.**REFERENCES:**
1. ACGIH [?].
2. Althoff H [1973]. Todliche perchlormethylmercaptan-intoxikation. Arch Toxikol *31*:121-134. [From ACGIH [1991]. Perchloromethyl mercaptan. In: Documentation of the threshold limit values and biological exposure indices. 6th ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 1195-1196.]
3. Flury F, Zernik F [1931]. Schädliche gase dämpfe, nebel, rauch- und staubarten. Berlin, Germany: Verlag von Julius Springer, p. 362 (in German).
4. Izmerov NF, Sanotsky IV, Sidorov KK [1982]. Toxicometric parameters of industrial toxic chemicals under single exposure. Moscow, Russia: Centre of International Projects, GKNT, p. 97.
5. Marhold JV [1972]. Sbornik vysledku toxixologiekeho vysetreni latek a pripravku. Prague, Czechoslovakia: Institut Prumyclu, p. 13 (in Czechoslovakian).
6. Prentiss AM [1937]. Chemicals in war. A treatise on chemical warfare. New York, NY: McGraw-Hill Book Company, Inc., p. 154.
7. Vernot EH, MacEwen JD, Haun CC, Kinkead ER [1977]. Acute toxicity and skin corrosion data for some organic and inorganic compounds and aqueous solutions. Toxicol Appl Pharmacol *42*(2):417-423.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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