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Isopropyl acetate																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 108–21–4
**NIOSH REL:** The 1989 OSHA PEL may not be protective to workers.
**Current OSHA PEL:** 250 ppm (950 mg/m3) TWA
**1989 OSHA PEL:** 250 ppm (950 mg/m3) TWA, 310 ppm (1,185 mg/m3) STEL
**1993-1994 ACGIH TLV:** 250 ppm (1,040 mg/m3) TWA, 310 ppm (1,290 mg/m3) STEL
**Description of substance:** Colorless liquid with a fruity odor.
**LEL**(@100°F)**:** 1.8% (10% LEL(@100°F), 1,800 ppm)
**Original (SCP) IDLH:** 16,000 ppm
**Basis for original (SCP) IDLH:** The chosen IDLH is based on the UCC [1970] report that a 4-hour exposure to 16,000 ppm killed 1 of 6 rats.
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA:**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50** **(ppm)**
    **LCLo** **(ppm)**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived value**Rat RatRat
    Pozzani et al. 1959 Smyth et al. 1954Smyth et al. 1954
    11,918 LC83: 32,000LC17: 16,000
    ----- ----------
    8 hr 4 hr4 hr
    29,795 ppm (2.5) 64,000 ppm (2.0)32,000 ppm (2.0)
    2,980 ppm 6,400 ppm3,200 ppm**Other animal data:** It has been stated that isopropyl acetate is comparable in toxicity to ethyl acetate and n-propyl acetate [ACGIH 1991].
 **Human data:** None relevant for use in determining the revised IDLH.
 
 **Revised IDLH:** 1,800 ppm **Basis for revised IDLH:** The revised IDLH for isopropyl acetate is 1,800 ppm based on analogies to ethyl acetate and n-propyl acetate [ACGIH 1991]. This value is also 10% of the lower explosive limit of 1.8% (which was determined at 100°F).**REFERENCES:**
1. ACGIH [1991]. Isopropyl acetate. In: Documentation of the threshold limit values and biological exposure indices. 6th ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 826-827.
2. Pozzani UC, Weil CS, Carpenter CP [1959]. The toxicological basis of threshold limit values: 5. The experimental inhalation of vapor mixtures by rats, with notes upon the relationship between single dose inhalation and single dose oral data. Am Ind Hyg Assoc J *20*:364-369.
3. Smyth HF Jr, Carpenter CP, Weil CS, Pozzani UC [1954]. Range-finding toxicity data: list V. AMA Arch Ind Hyg Occup Med *10*:61-68.
4. UCC [1970]. Toxicology studies: isopropyl acetate. New York, NY: Union Carbide Corporation.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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