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Chromium(III) compounds [as Cr(III)]																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** Varies
**NIOSH REL:** 0.5 mg/m3 TWA
**Current OSHA PEL:** 0.5 mg/m3 TWA
**1989 OSHA PEL:** Same as current PEL
**1993­1994 ACGIH TLV:** 0.5 mg/m3 TWA
**Description of Substance:** Varies
**Original (SCP) IDLH*:** No Evidence [*Note: “Effective” IDLH = 250 mg Cr(III)/m3 — see discussion below.]
**Basis for original (SCP) IDLH:** ACGIH [1971] noted that early studies indicated trivalent chromium to be essentially nontoxic [Akatsuka and Fairhall 1934]. The available toxicological data show no evidence that an acute exposure to a high concentration of soluble chromic salts would impede escape or cause any irreversible health effects within 30 minutes. For this draft technical standard, therefore, respirators have been selected on the basis of the assigned protection factor afforded by each device. However, for some particulate substances for which no evidence of an IDLH exists, the determination of allowable respiratory protection based on protection factors may result in the assignment of respirators for concentrations that are not likely to be encountered in the occupational environment. Therefore, for all such particulate substances it has been arbitrarily determined that only the “most protective” respirators are permitted for use in concentrations exceeding 500 × the OSHA PEL; in the case of chromium(III) compounds, 500 × the OSHA PEL of 0.5 mg Cr(III)/m3 is 250 mg Cr(III)/m3.
**Short­term exposure guidelines:** None developed
**ACUTE TOXICITY DATA**
**Lethal dose data:**

**Species**
    **Reference**
    **Route**
    **LD50** **(mg/kg)**
    **LDLo** **(mg/kg)**
    **Adjusted LD**
    **Derived value**CrCl3Rat
    Gekkan Yakuji 1980
    oral
    1,870
    -----
    4,320 mg Cr(III)/m3
    432 mg Cr(III)/m3CrF3G. pig
    Gekkan Yakuji 1980
    oral
    150
    -----
    500 mg Cr(III)/m3
    50 mg Cr(III)/m3Cr(NO3)2RatMouse
    Gekkan Yakuji 1980Sangyo Igaku 1978
    oraloral
    3,250110
    ----------
    4,961 mg Cr(III)/m3168 mg Cr(III)/m3
    496 mg Cr(III)/m317 mg Cr(III)/m3
 **Human data:** It has been reported that trivalent chromium compounds (i.e., chromic salts) have a low order of toxicity and provide little industrial hazard [ACGIH 1971; Akatsuka and Fairhall 1934; Clayton and Clayton 1981]
 
 **Revised IDLH:** 25 mg Cr(III)/m3**Basis for revised IDLH:** No inhalation toxicity data are available on which to base an IDLH for chromium(III) compounds. Therefore, the revised IDLH for chromium(III) compounds is 25 mg Cr(III)/m3 based on acute oral toxicity data in animals [Gekkan Yakuji 1980; Sangyo Igaku 1978]. This may be a conservative value due to the lack of relevant acute toxicity data for workers exposed to concentrations above 25 mg Cr(III)/m3.
**REFERENCES:**
1. ACGIH [1971]. Chromium (as Cr). In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 56.
2. Akatsuka K, Fairhall LT [1934]. The toxicology of chromium. J Ind Hyg *16*:1­28.
3. Clayton GD, Clayton FE, eds. [1981]. Patty’s industrial hygiene and toxicology. 3rd rev. ed. Vol. 2A. Toxicology. New York, NY: John Wiley & Sons, Inc., pp. 1593­1596.
4. Gekkan Yakuji (Pharmaceuticals Monthly) [1980]; *22*(2):291­298 (in Japanese).
5. Sangyo Igaku (Japanese Journal of Industrial Health) [1978]; *20*:590­591 (in Japanese).
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								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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