Exhibit 10.51


 


	 	Xenetic
                                         Biosciences, Inc.





40 Speen Street,


Suite 102


Framingham,
MA 01701


t
781-778-7720


e info@xeneticbio.com


 







 


[DATE]


[NAME]


[ADDRESS]


 


Re: Board of Directors Appointment


 


Dear [_____________]:


 


This Letter Agreement (the “Agreement”)
is to confirm the terms of your proposed appointment on [___________] as a non-employee, [independent] Director of the Board of
Directors (the “Board”) of Xenetic Biosciences, Inc. (the “Company”).


 


Overall, in terms of time commitment, we
expect your attendance at all the meetings of the Board and meetings of such committees of the Board that you will be appointed
to (as applicable). In addition, you will be expected to devote appropriate preparation time ahead of each meeting. By accepting
this appointment, you have confirmed that you are able to allocate sufficient time to meet the expectations of this position.


 


1.    
Consideration. For and in consideration of the services to be performed by you, the Company agrees to compensate
you as follows:


 


		1.1	Director Fee. A director fee equal to $[_______] per annum, payable quarterly (the “Board
Meeting Fee”) will be the cash compensation for your role as a director, as well as any Board committees, as chair or as
a member, you may participate.



 


		1.2	Stock Option. Subject to all approvals required by law, the Company will grant you, pursuant
to an equity incentive plan or such other plan to be adopted by the Company from time to time (the “Plan”) and upon
such terms and conditions as determined by the Compensation Committee or the Board (as applicable), an option to purchase [________]
shares of common stock of the Company at a strike price determined by the closing price of the common stock on the date of such
grant (the “Initial Option”). This option shall be exercisable as provided herein and shall vest [quarterly over twelve
months] so long as you are a member of our Board. An additional option to purchase [____] shares of Company common stock shall
be granted for service each year at the date of the Company’s Annual Meeting of Shareholders commencing with the [____] Annual
Meeting of Shareholders (together with the Initial Option, the “Options”). The exercise price shall be determined by
the closing price of the common stock on the date of such grant.



 


If your service
on the Board is terminated or ends for any reason, all granted Options that have not vested shall be forfeited, and any Options
that have vested, but have not been exercised, may be exercisable by you any time within three (3) months following the termination
of your Board position (the “Termination Exercise Period”). Any Options that are not exercised within the Termination
Exercise Period shall expire immediately.


 


A.             
Term of Options. All Options, if and to the extent vested according to Section 1.2 above, shall be in effect for
a period of 10 years commencing immediately after the granting of all Options granted to you under this Agreement, and shall expire
immediately thereafter, unless terminated sooner as provided in Section 1.2. Without derogating from the aforesaid, if the Plan
that shall be approved by the Company shall include additional provisions related to expiration of Options, such provisions shall
also apply with respect to all Options granted to you under this Agreement.


 


B.             
Vesting. All Options granted to you shall vest as provided in Section 1.2.


 


C.             
Price. The exercise price of the Options shall be equal to the Company’s closing stock price on the date of
your grant.


 


D.             
General. All Options granted to you shall be in effect subject to your continuous service as a Director and subject
to the terms and conditions of the Company’s Plan, including such terms related to vesting and expiration, and subject to
such terms and conditions as will be approved by the Company, at its sole discretion. In case of contradiction between the provisions
of this Agreement and the provisions of the Plan, the provisions of the Plan shall supersede.


 


 


 






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E.              
Certain Representations. You represent and agree that you are accepting the option to purchase shares of the Company’s
common stock being issued to you pursuant to this Agreement for your own account and not with a view to or for sale of distribution
thereof. You understand that the securities are restricted securities and you understand the meaning of the term “restricted
securities.” You further represent that you were not solicited by publication of any advertisement in connection with the
receipt of the shares and that you have consulted tax counsel as needed regarding the shares.


 


		1.3	The Company agrees to reimburse you for out-of-pocket expenses incurred by you in connection with
your service, including out-of-pocket expenses, transportation, and airfare on the Company’s business, provided that such
expenses are against original and valid receipts (the “Expenses”).



 


		1.4	Payment of the Expenses, as applicable, shall be made against your itemized invoice following the
receipt of the relevant invoice, which invoice shall be submitted to the Company within seven (7) days of the end of each calendar
month during the term of this Agreement.



 


		1.5	For the avoidance of any doubt, the Board Meeting Fee and the Options (subject to their terms)
and the aforementioned Expenses constitute the full and final consideration for your appointment, and you shall not be entitled
to any additional consideration, of any form, for your appointment and service.



 


		2.	The term of your appointment as a non-employee, [independent] director of the Company shall be
for one year or until the next Annual Meeting of Shareholders and shall be renewable on a yearly basis by vote of the shareholders
or appointment by the Board.



 


		3.	You will undertake such travelling as may reasonably be necessary for the performance of your duties,
including travelling for Board meetings and site visits if required.



 


		4.	You will undertake such duties and powers relating to the Company and any subsidiaries or associated
companies (the “Group”) as the Board may from time to time reasonably request. The Board as a whole is collectively
responsible for promoting the success of the Company by directing and supervising the Company’s affairs, inter alia, as follows:



 


		4.1	Providing entrepreneurial leadership of the Group within a framework of prudent and effective controls
which enable risk to be assessed and managed; and



 


		4.2	Setting the Group’s strategic aims, ensuring that the necessary financial and human resources
are in place for the Group to meet its objectives and reviewing management performance; and



 


		4.3	Setting the Group’s values and standards and ensuring that its obligations to its shareholders
and others are understood and met, including, but not limited to:



 


A.             
Managing conflicts of interest that may arise in Board meetings; and


 


B.             
Ensuring that all Board members are acting in the best interests of all shareholders.


 


		5.	Confidential Information.



 


		5.1	You undertake to the Company that you shall maintain in strict confidentiality all trade, business,
technical or other information regarding the Company, the Group, its affiliated entities and their business affairs including,
without limitation, all marketing, sales, technical and business know-how, intellectual property, trade secrets, identity and requirements
of customers and prospective customers, the Company’s methods of doing business and any and all other information relating
to the operation of the Company (collectively, the “Confidential Information”). You shall at no time disclose any Confidential
Information to any person, firm, or entity, for any purpose unless such disclosure is required in order to fulfill your responsibilities
as director. You further undertake that you shall not use such Confidential Information for personal gain.



 


 


 






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“Confidential
Information” shall not include information that (i) is or becomes part of the public domain other than as a result of disclosure
by you, (ii) becomes available to you on a non-confidential basis from a source other than the Company, provided that the source
is not bound with respect to that information by a confidentiality agreement with the Group or is otherwise prohibited from transmitting
that information by a contractual legal or other obligation, or (iii) can be proven by you to have been in your possession prior
to disclosure of the information by the Company.


 


In the event
that you are requested or required (by oral questions, interrogatories, requests for information or documents, subpoena, civil
investigative demand or other process) to disclose any Confidential Information, it is agreed that you, to the extent practicable
under the circumstances, will provide the Company with prompt notice of any such request or requirement so that the Company may
seek an appropriate protective order or waive compliance with this Section 5. If a protective order or the receipt of a waiver
hereunder has not been obtained, you may disclose only that portion of the Confidential Information which you are legally compelled
to disclose.


 


		6.	Blackout Period. You understand that we have, or intend to have, a policy pursuant to which,
among other restrictions, no officer, director or key executive (or any of their affilaites) may engage in transactions in
our stock during the periods commencing at the close of business on the 15th day before the end of each fiscal quarter
and ending after markets close on the second full trading day after the financial information for the then-current quarter has
been publicly released, subject to the terms and conditions of the Company’s policy.



 


		7.	Term and Termination.



 


		7.1	Subject to Section 7.2 hereunder, this Agreement and appointment shall terminate immediately and
without claim for compensation on the occurrence of any of the following events:



 


A.             
If you resign as a Director of the Company for any reason; and/or


 


B.             
If you are removed or not re-appointed as a Director of the Board at an Annual Meeting of Shareholders of the Company in
accordance with the requirements of the Business Corporation Law of the State of Nevada and/or any other applicable law or regulation
and/or the Company’s Articles of Incorporation; and/or


 


C.             
If you have been declared bankrupt or made an arrangement or composition with or for the benefit of your creditors; and/or


 


D.             
If you have been disqualified from acting as a Director (including, but not limited to, an event in which you are declared
insane or become of unsound mind or become physically incapable of performing your functions as Director for a period of at least
sixty (60) days); and/or


 


E.              
If an order of a court having jurisdiction over the Company requires you to resign.


 


		6.2	Any termination of this Agreement shall be without payment of damages or compensation (except that
you shall be entitled to any accrued Board Meeting Fees or Expenses properly incurred under the terms of this Agreement prior to
the date of such termination).



 


		7.	The Company will put directors’ and officers’ liability insurance in place within sixty
(60) days of this Agreement, if not already in place, and will use commercial reasonable efforts to maintain such insurance coverage
for the full term of your appointment.



 


		8.	On termination of this appointment, you shall return all property belonging to the Group, together
with all documents, papers, disks and information, howsoever stored, relating to the Group and used by you in connection with your
position with the Company.



 


		9.	Subject to the proper performance of your obligations to the Company under this Agreement and any
applicable law, the Company agrees that you will be free to accept other appointments, directorships and chairmanships provided
that:



 


 


 






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		9.1	They do not in any way conflict with the interests of the Company or any member of the Group; and



 


		9.2	They do not restrict you from devoting the necessary time and attention properly to services to
be performed under this Agreement; and



 


		9.3	In the event that you become aware of any potential conflicts of interest, these must be disclosed
to the Chairman and/or the Chief Executive Officer (the “CEO”) of the Company as soon as they become apparent.



 


		10.	The performance of individual Directors, the Chairman and the Board and its committees is evaluated
annually. If, in the interim, there are any matters which cause you concern about your position, you should discuss them with the
Chairman and/or the CEO as soon as is appropriate.



 


		11.	In addition to any right pursuant to applicable law, occasions may arise when you consider that
you need professional advice in the furtherance of your duties as a director. Circumstances may occur when it will be appropriate
for you to seek such advice from independent advisors at the Company’s expense, to the extent provided under applicable law
and subject to the prior written approval of the CEO and/or the Board.



 


		12.	This Agreement refers to your appointment as a Director of the Company and your future membership
on the committees of the Board.



 


		13.	You shall ensure that you comply at all times with the Company’s inside trading policies
as in effect from time to time.



 


		14.	You shall discharge your general duties as a Director pursuant to the Company’s Articles
of Incorporation, Bylaws and applicable law.



 


		15.	This Agreement shall be governed by and construed in accordance with the law of the State of Massachusetts.



 


Please sign the attached copy of this Agreement
and return it to the Company to signify your acceptance of the terms set out above.


 


***


 








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Sincerely yours,


 


XENETIC BIOSCIENCES INC.


 


 


___________________________


Name: Jeffrey Eisenberg


Title: Chief Executive Officer


 


 


 


AGREED AND ACKNOWLEDGED BY:


 


 


 


Name of Director:


 


 




 


 


 






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