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Mining Publication: Diesel Exhaust Particulate Material Expression of in Vitro Genotoxic Activities When Dispersed Into a Phospholipid Component of Lung Surfactant
Keywords: Diesel exhaust Diesel particulate matter Lungs
This page is archived for historical purposes and is no longer being maintained or updated.
Original creation date: March 2009
Authors: X Shi, MJ Keane, TM Ong, JC Harrison, JE Slaven, AD Bugarski, M Gautam, WE Wallace
Conference Paper - March 2009
Download PDF Document (0.33 MB)
NIOSHTIC2 Number: 20035189
J Phys: Conf Ser, Inhaled Particles X 2009 Mar; 151(1):012021
Bacterial mutagenicity and mammalian cell chromosomal and DNA damage in vitro assays were performed on a diesel exhaust particulate material (DPM) standard in two preparations: as an organic solvent extract, and as an aqueous dispersion in a simulated pulmonary surfactant. U.S. National Institute for Standards and Technology DPM SRM 2975 expressed mutagenic activity in the Salmonella reversion assay, and for in vitro genotoxicity to mammalian cells as micronucleus induction and as DNA damage in both preparations: as an acetone extract of the DPM mixed into dimethylsulfoxide, and as a mixture of whole DPM in a dispersion of dipalmitoyl phosphatidyl choline. Dispersion in surfactant was used to model the conditioning of DPM depositing on the deep respiratory airways of the lung. DPM solid residue after acetone extraction was inactive when assayed as a surfactant dispersion in the micronucleus induction assay, as was surfactant dispersion of a respirable particulate carbon black. In general, a given mass of the DPM in surfactant dispersion expressed greater activity than the solvent extract of an equal mass of DPM.
Image of publication Diesel Exhaust Particulate Material Expression of in Vitro Genotoxic Activities When Dispersed Into a Phospholipid Component of Lung SurfactantConference Paper - March 2009
Download PDF Document (0.33 MB)
NIOSHTIC2 Number: 20035189
J Phys: Conf Ser, Inhaled Particles X 2009 Mar; 151(1):012021
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Diesel Exhaust Aerosol, Review of Measurement Technology
Differential Pressure as a Measure of Particulate Matter Emissions from Diesel Engines
Effects of Diesel Exhaust Aftertreatment Devices on Concentrations and Size Distribution of Aerosols in Underground Mine Air
Instrumentation for Diesel Particulate Matter Emissions Research
Mutagenicity of Diesel Exhaust Particles from an Engine with Differing Exhaust After Treatments
Size Distribution and Deposition in Human Respiratory Tract: Particle Mass and Number
Technology News 514 - The Air Quantity Estimator (AQE): A New Computer Software Tool for Large-opening Mine Ventilation Planning
Page last reviewed: September 21, 2012
Page last updated: September 21, 2012
Content source: National Institute for Occupational Safety and Health, Mining Program
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