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Isopropyl glycidyl ether																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 4016–14–2
**NIOSH REL:** 50 ppm (240 mg/m3) 15-minute CEILING
**Current OSHA PEL:** 50 ppm (240 mg/m3) TWA
**1989 OSHA PEL:** 50 ppm (240 mg/m3) TWA, 75 ppm (360 mg/m3) STEL
**1993-1994 ACGIH TLV:** 50 ppm (238 mg/m3) TWA, 75 ppm (356 mg/m3) STEL
**Description of substance:** Colorless liquid.
**LEL:** . . Unknown
**Original (SCP) IDLH:** 1,000 ppm
**Basis for original (SCP) IDLH:** The chosen IDLH is based on the mouse 4-hour LC50 of 1,500 ppm and the rat 8-hour LC50 of 1,100 ppm [Hine et al. 1956 cited by Patty 1963].
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA:**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50** **(ppm)**
    **LCLo** **(ppm)**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived value**Mouse Rat
    Hine et al. 1956 Hine et al. 1956
    1,500 1,100
    ----- -----
    4 hr 8 hr
    3,000 ppm (2.0) 2,750 ppm (2.5)
    300 ppm 275 ppm**Human data:** Workers exposed to 400 ppm have suffered irritation of the eyes and respiratory tract [Hine et al. 1956].
 
 **Revised IDLH:** 400 ppm **Basis for revised IDLH:** The revised IDLH for isopropyl glycidyl ether is 400 ppm based on acute inhalation toxicity data in workers [Hine et al. 1956]. This may be a conservative value due to the lack of relevant acute toxicity data for workers exposed to concentrations above 400 ppm.**REFERENCES:**
1. Hine CH, Kodama JK, Wellington JS, Dunlap MK, Anderson HH [1956]. The toxicology of glycidol and some glycidyl ethers. AMA Arch Ind Health *14*:250-264.
2. Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 1638.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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