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alpha-Methyl styrene																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 98–83–9
**NIOSH REL:** 50 ppm (240 mg/m3) TWA, 100 ppm (485 mg/m3) STEL
**Current OSHA PEL:** 1:00 ppm (480 mg/m3) CEILING
**1989 OSHA PEL:** 50 ppm (240 mg/m3) TWA, 100 ppm (485 mg/m3) STEL
**1993-1994 ACGIH TLV:** 50 ppm (242 mg/m3) TWA, 100 ppm (483 mg/m3) STEL
**Description of substance:** Colorless liquid with a characteristic odor.
**LEL**:. . . 1.9% (10% LEL, 1,900 ppm)
**Original (SCP) IDLH:** 5,000 ppm
**Basis for original (SCP) IDLH:** Because no data on acute inhalation toxicity are available on which to base the IDLH for a-methyl styrene, the chosen IDLH is based on an analogy with styrene which has an IDLH of 5,000 ppm.
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA:**
**Lethal dose data:**

**Species**
    **Reference**
    **Route**
    **LD50 (mg/kg)**
    **LDLo (mg/kg)**
    **Adjusted LD**
    **Derived value**Rat
    Wolf et al. 1956
    oral
    4,900
    -----
    6,982 ppm
    698 ppm**Other animal data:** A considerable number of rats and guinea pigs exposed to 3,000 ppm for 7 to 8 hours/day, 5 days/week for up to 6 months died [Gerarde 1960; Wolf et al. 1956]. Rats and guinea pigs had slight changes in liver and kidney weights and some reduction in body weight following exposure to 800 ppm for 7 hours/day, 5 days/week for 27 days [Wolf et al. 1956]. No adverse effects were noted in rats, rabbits, mice, monkeys, and guinea pigs exposed 7 hours/day, 5 days/week for 5 months to 200 ppm [Wolf et al. 1956].
 **Human data:** Four volunteers reported a definite unpleasant odor and slight eye irritation after about 2 minutes of exposure to 200 ppm [Wolf et al. 1956]. Strong eye and nasal irritation has been noted at concentrations above 600 ppm [Gerarde 1960; Wolf et al. 1956].
 
 **Revised IDLH:** 700 ppm **Basis for revised IDLH:** The revised IDLH for a-methyl styrene is 700 ppm based on acute toxicity data in humans [Wolf et al. 1956] and animals [Gerarde 1960; Wolf et al. 1956] and an analogy to styrene which has a revised IDLH of 700 ppm.**REFERENCES:**
1. Gerarde HW [1960]. Toxicology and biochemistry of aromatic hydrocarbons. Princeton, NJ: Elsevier Publishing Company, pp. 131-133.
2. Wolf MA, Rowe VK, McCollister DD, et al. [1956]. Toxicological studies of certain alkylated benzenes and benzene. AMA Arch Ind Health *14*:387-398.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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