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Demeton																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 8065–48–3
**NIOSH REL:** 0.1 mg/m3 TWA [skin]
**Current OSHA PEL:** 0.1 mg/m3 TWA [skin]
**1989 OSHA PEL:** Same as current PEL
**1993-1994 ACGIH TLV:** 0.11 mg/m3 (0.01 ppm) TWA [skin]
**Description of Substance:** Amber, oily liquid with a sulfur-like odor.
**LEL:**. . Unknown
**Original (SCP) IDLH:** 20 mg/m3
**Basis for original (SCP) IDLH:** No useful data on acute inhalation toxicity are available on which to base the IDLH for demeton. The chosen IDLH, therefore, has been based on an analogy with parathion which has an IDLH of 20 mg/m3.
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50**
    **LCLo**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived** **value**Rat Cat
    Izmerov et al. 1982 Izmerov et al. 1982
    ----- -----
    15 mg/m315 mg/m3
    4 hr 4 hr
    30 mg/m3 (2.0) 30 mg/m3 (2.0)
    3.0 mg/m33.0 mg/m3
 **Lethal dose data:**
 
 **Species**
    **Reference**
    **Route**
    **LD50** **(mg/kg)**
    **LDLo** **(mg/kg)**
    **Adjusted LD**
    **Derived** **value**Rabbit MouseRat
    Gurevich et al. 1962 Rosival et al. 1958Schafer 1972
    oral oraloral
    ----- ----------
    5 7.851.7
    35 mg/m355 mg/m312 mg/m3
    3.5 mg/m35.5 mg/m31.2 mg/m3
 **Other animal data:** In a subchronic inhalation study, no signs of illness resulted from the first day of exposure to 3 mg/m3 for 2 hours, tremors were noted on the second day, lacrimation and more severe tremors on the third day, and 10 of the 17 rats died during the fourth day [Deichmann and Rakoczy 1955]. It has been reported that the acute oral and dermal toxicity of demeton in mammals is approximately the same as that of parathion; the American Conference of Governmental Industrial Hygienists TLV for demeton is based on an analogy to parathion [ACGIH 1991].
 **Human data:** None relevant for use in determining the revised IDLH.
 
 **Revised IDLH:** 10 mg/m3**Basis for revised IDLH:** The revised IDLH for demeton is 10 mg/m3 based on an analogy with parathion [ACGIH 1991] which has a revised IDLH of 10 mg/m3.
**REFERENCES:**
1. ACGIH [1991]. Demeton. In: Documentation of the threshold limit values and biological exposure indices. 6th ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 385-386.
2. Deichmann WB, Rakoczy R [1955]. Toxicity and mechanism of action of systox. AMA Arch Ind Health *11*:324-331.
3. Gurevich BA, Smetevin NE, Lubetsky KZ [1962]. On the question of toxicity of a new defoliant folex. Gig Sanit *27*(8):97-99 (in Russian).
4. Izmerov NF, Sanotsky IV, Sidorov KK [1982]. Toxicometric parameters of industrial toxic chemicals under single exposure. Moscow, Russia: Centre of International Projects, GKNT, p. 52.
5. Rosival L, Selecky FV, Vrbovsky L [1958]. Akutna experimentalna otrava organofosforovymi insekticidmi. Bratislavske Lekarske Listy *38*:151-160 (in Czechoslovakian).
6. Schafer EW [1972]. The acute oral toxicity of 369 pesticidal, pharmaceutical and other chemicals to wild birds. Toxicol Appl Pharmacol *21*:315-330.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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