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2-Pentanone																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 107–87–9
**NIOSH REL:** 150 ppm (530 mg/m3) TWA
**Current OSHA PEL:** 200 ppm (700 mg/m3) TWA
**1989 OSHA PEL:** 200 ppm (700 mg/m3) TWA, 250 ppm (875 mg/m3) STEL
**1993-1994 ACGIH TLV:** 200 ppm (705 mg/m3) TWA, 250 ppm (881 mg/m3) STEL
**Description of substance:** Colorless to water-white liquid with a characteristic acetone-like odor.
**LEL:** . . 1.5% (10% LEL, 1,500 ppm)
**Original (SCP) IDLH:** 5,000 ppm
**Basis for original (SCP) IDLH:** The chosen IDLH is based on the statement by Patty [1963] that the maximum concentration that caused no serious disturbances in guinea pigs in 1 hour was 5,000 ppm [Yant et al. 1936].
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA:**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50 (ppm)**
    **LCLo (ppm)**
    **Time**
    **Adjusted 0.5-hr LC (CF)**
    **Derived value**Rat
    Smyth et al. 1962
    LC17: 2,000
    -----
    4 hr
    4,000 ppm (2.0)
    400 ppmRat
    Smyth et al. 1962
    LC100: 4,000
    -----
    4 hr
    8,000 ppm (2.0)
    800 ppmG. pig
    Yant et al. 1936
    -----
    50,000
    50 min
    60,000 ppm (1.2)
    6,000 ppmG. pig
    Yant et al. 1936
    -----
    13,000
    5 hr
    27,950 ppm (2.15)
    2,795 ppm**Lethal dose data:**
 
 **Species**
    **Reference**
    **Route**
    **LD50 (mg/kg)**
    **LDLo (mg/kg)**
    **Adjusted LD**
    **Derived value**Rat
    Clayton and Clayton 1982
    oral
    1,600
    -----
    3,128 ppm
    313 ppmMouse
    Clayton and Clayton 1982
    oral
    1,600
    -----
    3,128 ppm
    313 ppm**Human data:** Exposure to a concentration of 1,500 ppm was associated with complaints of ocular and upper respiratory irritation [Yant et al. 1936].
 
 **Revised IDLH:** 1,500 ppm **Basis for revised IDLH:** The revised IDLH for 2-pentanone is 1,500 ppm based on acute inhalation toxicity data in humans [Yant et al. 1936]. This may be a conservative value due to the lack of relevant acute toxicity data for workers exposed to concentrations above 1,500 ppm. Also, this value is 10% of the lower explosive limit of 1.5%.**REFERENCES:**
1. Clayton GD, Clayton FE, eds. [1982]. Patty’s industrial hygiene and toxicology. 3rd rev. ed. Vol. 2A. Toxicology. New York: John Wiley & Sons, Inc., p. 4735.
2. Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 1734.
3. Smyth HF Jr, Carpenter CP, Weil CS, Pozzani UC, Striegel JA [1962]. Range-finding toxicity data: list VI. AMA Arch Ind Hyg Occup Med *23*:95-107.
4. Yant WP, Patty FA, Schrenk HH [1936]. Acute response of guinea pigs to vapors of some new commercial organic compounds. IX. Pentanone (methyl propyl ketone). Public Health Rep *51*:392-399.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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