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p-Anisidine																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number**: 104-94-9
**NIOSH REL**: 0.5 mg/m3 TWA [skin]
**Current OSHA PEL**: 0.5 mg/m3 TWA [skin]
**1989 OSHA PEL**: Same as current PEL
**1993-1994 ACGIH TLV**: 0.1 ppm (0.5 mg/m3) TWA [skin]
**Description of substance**: Yellow to brown, crystalline solid with an amine-like odor.
**LEL**: Unknown
**Original (SCP) IDLH**: 50 mg/m3
**Basis for original (SCP) IDLH**: Because no data on acute inhalation toxicity are available for anisidine (o-, p-isomers), the chosen IDLH is based on chronic data. ACGIH [1971] reported that mice survived exposures to 10 to 30 mg/m3 for 2 hours/day, 6 days/week for 1 month; a decrease in the excitability of nerves was noted [Zaeva and Fedorova 1962]. Because mice survived 30 mg/m3, 2 hours/day, 6 days/week for 1 month, a worker should be able to escape from 50 mg/m3 without injury or irreversible health effects.
**Short-term exposure guidelines:** None developed
ACUTE TOXICITY DATA
**Lethal dose data:**
LD50
    LDLo
    
    DerivedSpecies
    Reference
    Route
    (Mg/kg)
    (mg/kg)
    Adjusted LD
    ValueRabbit
    IARC 1982
    oral
    2,900
    -----
    20,300 mg/m3
    2,030 mg/m3Mouse
    IARC 1982
    oral
    1,300
    -----
    9,100 mg/m3
    910 mg/m3Mouse
    Nippon 1956
    oral
    -----
    1,000
    7,000 mg/m3
    700 mg/m3Rat
    Sziza and Podragyai 1957
    oral
    1,400
    -----
    9,800 mg/m3
    980 mg/m3**Other animal data:** Mice have survived exposures to concentrations of 10 to 30 mg/m3 for 2 hours/day, 6 days/week for 1 month with a only decrease in the excitability of nerves noted [Zaeva and Fedorova 1962].
 **Human data:** None relevant for use in determining the revised IDLH.
 **Revised IDLH:** 50 mg/m3 [Unchanged]**Basis for revised IDLH:** Based on subchronic inhalation toxicity data in animals [Zaeva and Fedorova 1962], the original IDLH for p-anisidine of 50 mg/m3 is not being revised at this time.References:
ACGIH [1971]. Anisidine (o-, p-isomers). In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 14.
IARC [1982]. IARC monographs on the evaluation of carcinogenic risk of chemicals to humans. Vol. 27. Lyon, France: World Health Organization, International Agency for Research on Cancer, p. 63.
Nippon Yakurigaku Zasshi (Japanese Journal of Pharmacology) [1956]; *52*:215-221 (in Japanese).
Sziza M, Podragyai L [1957]. Toxikologische untersuchung einiger in der ungarischen industrie zur anwendung gelangenden aromatischen amidoverbindungen. Arch Gewerbepath Gewerbehyg *15*:447-456 (in German).
Zaeva GN, Fedorova VI [1962]. Toxsikol Nov Prom Khim Vesh *4*:91 (in Russian).

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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