[Federal Register Volume 72, Number 25 (Wednesday, February 7, 2007)]
[Notices]
[Pages 5725-5726]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 07-526]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health


Government-Owned Inventions; Availability for Licensing

AGENCY: National Institutes of Health, Public Health Service, HHS.

ACTION: Notice.

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SUMMARY: The invention listed below is owned by an agency of the U.S. 
Government and is available for licensing in the U.S. in accordance 
with 35 U.S.C. 207 to achieve expeditious commercialization of results 
of federally-funded research and development. Foreign patent 
applications are filed on selected inventions to extend market coverage 
for companies and may also be available for licensing.

ADDRESSES: Licensing information and copies of the U.S. patent 
applications listed below may be obtained by writing to the indicated 
licensing contact at the Office of Technology Transfer, National 
Institutes of Health, 6011 Executive Boulevard, Suite 325, Rockville, 
Maryland 20852-3804; telephone: 301/496-7057; fax: 301/402-0220. A 
signed Confidential Disclosure Agreement will be required to receive 
copies of the patent applications.

Metal Chelators and Target-Moiety Complexes for Imaging

    Available for licensing and commercial development are bifunctional 
metal chelators, metal chelator-targeting moiety complexes, metal 
chelator-targeting moiety-metal conjugates, kits, and methods of 
preparing them in a non-aqueous, automated peptide synthesizer system. 
These bifunctional chelators are useful for radiolabeling targeting 
moieties with SPECT and PET radioisotopes for molecular imaging for 
diagnosis and/or treatment of cancer. The metal chelators may be used 
in conventional synthetic methods to form targeting moieties [e.g., 
peptides, proteins, and Starburst polyamidoamine dendrimers (PAMAM)], 
capable of conjugating diagnostic and/or therapeutic metals. The 
formulae for two such chelators are shown below:

[[Page 5726]]

[GRAPHIC] [TIFF OMITTED] TN07FE07.015

    Inventors: Martin Wade Brechbiel and Thomas Clifford (NCI).
    Publications:
    1. T Clifford et al. Validation of a novel CHX-A'' derivative 
suitable for peptide conjugation: small animal PET/CT imaging using 
yttrium-86-CHX-A''-octreotide. J Med Chem. 2006 Jul 13;49(14):4297-
4304.
    2. HS Chong et al. Synthesis and evaluation of novel macrocyclic 
and acyclic ligands as contrast enhancement agents for magnetic 
resonance imaging. J Med Chem. 2006 Mar 23;49(6):2055-2062.
    Licensing Status: Available for exclusive or non-exclusive 
licensing or collaborative research opportunity.
    Patent Status: U.S. Provisional Application No. 60/603,781 filed 23 
Aug 2004 (HHS Reference No. E-317-2004/1-US-01); International Patent 
Application PCT/US2005/028125 filed 09 Aug 2005 (HHS Reference No. E-
317-2004/1[ndash']PCT-02).
    Licensing Contact: Michael A. Shmilovich, Esq.; 301/435-5019; 
<a href="/cdn-cgi/l/email-protection#c4b7aca9ada8abb2a984a9a5ada8eaaaadaceaa3abb2"><span class="__cf_email__" data-cfemail="2a5942474346455c476a474b434604444342044d455c">[email protected]</span></a>.

    Dated: January 30, 2007.
Steven M. Ferguson,
Director, Division of Technology Development and Transfer, Office of 
Technology Transfer, National Institutes of Health.
[FR Doc. 07-526 Filed 2-6-07; 8:45 am]
BILLING CODE 4140-01-P


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