| (Mark One)                                                                                                                                                                                                                                                                                                                       |
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| ý                                                                                                                                                                                                                                                                                                                           |   | ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 |
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| For the fiscal year ended December 31, 2015                                                                                                                                                                                                                                                                                 |
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| ☐                                                                                                                                                                                                                                                                                                                          |   | TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 |
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| For the transition period from                        to                         |
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| Commission file number 001-34375                                                                                                                                                                                                                                                                                                 |
| DELAWARE                                                       |   | 33-0827593                           |
|----------------------------------------------------------------|--------|--------------------------------------|
| (State or Other Jurisdiction of Incorporation or Organization) |   | (I.R.S. Employer Identification No.) |
|                                                           |   |                                 |
| 3020 CALLAN ROAD, SAN DIEGO, CALIFORNIA                        |   | 92121                                |
| (Address of principal executive offices)                       |   | (Zip Code)                           |
| Title of each class            | Name of each exchange on which registered |
|--------------------------------|-------------------------------------------|
| Common stock, par value $0.001 | NASDAQ Stock Market LLC                   |
| Large Accelerated Filer   ☐   | Accelerated Filer ý | Non-Accelerated Filer ☐            | Smaller reporting company ☐ |
|--------------------------------------------------------------|--------------------------|-----------------------------------------------|----------------------------------------|
|                                                         |                     | (Do not check if a smaller reporting company) |                                   |

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|   | CYTORI THERAPEUTICS, INC. |
|--------|---------------------------|
|   |                      |   |
|   | By:                       | /s/ Marc H. Hedrick, MD |
|   |                      | Marc H. Hedrick, MD |
|   |                      | President & Chief Executive Officer |
|   |                      | March 24, 2016 |

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| CYTORI THERAPEUTICS, INC. |
|---------------------------|
| EXHIBIT INDEX             |
| Exhibit Number            | Exhibit Title | Filed with this Form 10-K | Incorporated by Reference |
| Form                      | File No. | Date Filed |
| 3.1**                     | Composite Certificate of Incorporation. | X |   |   |   |
|                      |   |   |   |   |   |
| 3.2                       | Amended and Restated Bylaws of Cytori Therapeutics, Inc. |   | 10-Q | 000-32501Exhibit 3.2 | 08/14/2003 |
|                      |   |   |   |   |   |
| 3.3                       | Amendment to Amended and Restated Bylaws of Cytori Therapeutics, Inc. |   | 8-K | 001-34375 | 05/06/2014 |
|                      |   |   |   |   |   |
| 3.4                       | Certificate of Designation of Preferences, Rights and Limitations of Series A 3.6% Convertible Preferred Stock |   | 8-K | 001-034375 | 10/08/2014 |
|                      |   |   |   |   |   |
| 4.1                       | Warrant to Purchase Common Stock issued by the Company on October 14, 2008 in favor of Silicon Valley Bank, pursuant to the Loan and Security Agreement dated October 14, 2008. |   | 10-K | 000-32501Exhibit 10.62 | 03/06/2009 |
|                      |   |   |   |   |   |
| 4.2                       | Warrant to Purchase Common Stock issued by the Company on June 11, 2010 in favor of GE Capital Equity Investments, Inc., pursuant to the Amended and Restated Loan and Security Agreement dated June 11, 2010. |   | 8-K | 001-34375Exhibit 10.73 | 06/17/2010 |
|                      |   |   |   |   |   |
| 4.3                       | Warrant to Purchase Common Stock issued by the Company on June 11, 2010 in favor of Silicon Valley Bank, pursuant to the Amended and Restated Loan and Security Agreement dated June 11, 2010. |   | 8-K | 001-34375Exhibit 10.74 | 06/17/2010 |
|                      |   |   |   |   |   |
| 4.4                       | Warrant to Purchase Common Stock issued by the Company on June 11, 2010 in favor of Oxford Financial Corporation, pursuant to the Amended and Restated Loan and Security Agreement dated June 11, 2010. |   | 8-K | 001-34375Exhibit 10.75 | 06/17/2010 |
|                      |   |   |   |   |   |
| 4.5                       | Warrant to Purchase Common Stock issued by the Company on September 9, 2011 in favor of GE Capital Equity Investments, Inc., pursuant to the Amended and Restated Loan and Security Agreement dated September 9, 2011. |   | 8-K | 001-34375Exhibit 10.84 | 09/15/2011 |
|                      |   |   |   |   |   |
| 4.6                       | Warrant to Purchase Common Stock issued by the Company on September 9, 2011 in favor of Silicon Valley Bank, pursuant to the Amended and Restated Loan and Security Agreement dated September 9, 2011. |   | 8-K | 001-34375Exhibit 10.85 | 09/15/2011 |
|                      |   |   |   |   |   |
| 4.7                       | Warrant to Purchase Common Stock issued by the Company on September 9, 2011 in favor of Oxford Financial Corporation, pursuant to the Amended and Restated Loan and Security Agreement dated September 9, 2011. |   | 8-K | 001-34375Exhibit 10.86 | 09/15/2011 |
|                      |   |   |   |   |   |
| 4.8                       | Warrant to Purchase Common Stock issued by the Company on September 9, 2011 in favor of Oxford Financial Corporation, pursuant to the Amended and Restated Loan and Security Agreement dated September 9, 2011. |   | 8-K | 001-34375Exhibit 10.87 | 09/15/2011 |
|                      |   |   |   |   |   |
| 4.9                       | Warrant to Purchase Common Stock issued by the Company on June 28, 2013 in favor of Oxford Finance LLC pursuant to the Loan and Security Agreement dated June 28, 2013. |   | 10-Q | 001-34375Exhibit 4.17 | 08/09/2013 |
|                      |   |   |   |   |   |
| 4.10                      | Warrant to Purchase Common Stock issued by the Company on June 28, 2013 in favor of Oxford Finance LLC pursuant to the Loan and Security Agreement dated June 28, 2013. |   | 10-Q | 001-34375Exhibit 4.18 | 08/09/2013 |
|                      |   |   |   |   |   |
| 4.12                      | Warrant to Purchase Common Stock issued by the Company on June 28, 2013 in favor of Oxford Finance LLC pursuant to the Loan and Security Agreement dated June 28, 2013. |   | 10-Q | 001-34375Exhibit 4.19 | 08/09/2013 |
|                      |   |   |   |   |   |
| 4.13                      | Warrant to Purchase Common Stock issued by the Company on June 28, 2013 in favor of Oxford Finance LLC pursuant to the Loan and Security Agreement dated June 28, 2013. |   | 10-Q | 001-34375Exhibit 4.20 | 08/09/2013 |
|                      |   |   |   |   |   |
| 4.14                      | Warrant to Purchase Common Stock issued by the Company on June 28, 2013 in favor of Silicon Valley Bank pursuant to the Loan and Security Agreement dated June 28, 2013. |   | 10-Q | 001-34375Exhibit 4.21 | 08/09/2013 |
|                      |   |   |   |   |   |
| 4.15                      | Form of Warrant to Purchase Common Stock for Investors in the Units |   | 8-K | 001-34375 | 05/30/2014 |

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| 4.16    | Form of Warrant to Purchase Common Stock for Placement Agent of the Units                                                                                                                                                                                                                                         |   | 8-K    | 001-34375                | 05/30/2014 |
|---------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|--------|--------|--------------------------|------------|
|    |                                                                                                                                                                                                                                                                                                              |   |   |                     |       |
| 4.17    | Form of Amendment to Warrant to Purchase Common Stock.                                                                                                                                                                                                                                                            |   | 8-K    | 001-34375                | 09/08/2014 |
|    |                                                                                                                                                                                                                                                                                                              |   |   |                     |       |
| 4.18    | Form of Warrant to Purchase Common Stock.                                                                                                                                                                                                                                                                         |   | 8-K    | 001-34375                | 09/08/2014 |
|    |                                                                                                                                                                                                                                                                                                              |   |   |                     |       |
| 4.19    | Form of Warrant for Purchasers in the Units                                                                                                                                                                                                                                                                       |   | 8-K    | 001-034375               | 10/08/2014 |
|    |                                                                                                                                                                                                                                                                                                              |   |   |                     |       |
| 4.20    | Form of Initial Warrant to Purchase Common Stock                                                                                                                                                                                                                                                                  |   | 8-K    | 001-034375               | 05/05/2015 |
|    |                                                                                                                                                                                                                                                                                                              |   |   |                     |       |
| 4.21    | Form of Additional Warrant to Purchase Common Stock                                                                                                                                                                                                                                                               |   | 8-K    | 001-034375               | 05/05/2015 |
|    |                                                                                                                                                                                                                                                                                                              |   |   |                     |       |
| 4.22    | Form of Pre-Funded Warrant to Purchase Common Stock                                                                                                                                                                                                                                                               |   | 8-K    | 001-034375               | 05/05/2015 |
|    |                                                                                                                                                                                                                                                                                                              |   |   |                     |       |
| 4.23**  | Amendment to Common Stock Purchase Warrant                                                                                                                                                                                                                                                                        | X      |   |                     |       |
|    |                                                                                                                                                                                                                                                                                                              |   |   |                     |       |
| 4.4**   | Amendment to Series A-1 Warrant to Purchase Common Stock                                                                                                                                                                                                                                                          | X      |   |                     |       |
|    |                                                                                                                                                                                                                                                                                                              |   |   |                     |       |
| 4.25**  | Amendment to Series A-2 Warrant to Purchase Common Stock                                                                                                                                                                                                                                                          | X      |   |                     |       |
|    |                                                                                                                                                                                                                                                                                                              |   |   |                     |       |
| 10.1#   | Amended and Restated 1997 Stock Option and Stock Purchase Plan.                                                                                                                                                                                                                                                   |   | 10     | 000-32501Exhibit 10.1    | 03/30/2001 |
|    |                                                                                                                                                                                                                                                                                                              |   |   |                     |       |
| 10.1.1# | Board of Directors resolution adopted November 9, 2006 regarding determination of fair market value for stock option grant purposes (incorporated by reference to Exhibit 10.10.1 filed as Exhibit 10.10.1 to our Form 10-K Annual Report, as filed on March 30, 2007 and incorporated by reference  herein) |   | 10-K   | 000-32501Exhibit 10.10.1 | 03/30/2007 |
|    |                                                                                                                                                                                                                                                                                                              |   |   |                     |       |
| 10.2    | 2004 Equity Incentive Plan of Cytori Therapeutics, Inc                                                                                                                                                                                                                                                            |   | 8-K    | 000-32501Exhibit 10.1    | 08/27/2004 |
|    |                                                                                                                                                                                                                                                                                                              |   |   |                     |       |
| 10.3#   | Board of Directors resolution adopted November 9, 2006 regarding determination of fair market value for stock option grant purposes.                                                                                                                                                                              |   | 10-K   | 000-32501Exhibit 10.10.1 | 03/30/2007 |
|    |                                                                                                                                                                                                                                                                                                              |   |   |                     |       |
| 10. 4#  | Notice and Agreement for Stock Options Grant Pursuant to Cytori Therapeutics, Inc. 1997 Stock Option and Stock Purchase Plan; (Nonstatutory).                                                                                                                                                                     |   | 10-Q   | 000-32501Exhibit 10.19   | 11/15/2004 |
|    |                                                                                                                                                                                                                                                                                                              |   |   |                     |       |
| 10.5#   | Notice and Agreement for Stock Options Grant Pursuant to Cytori Therapeutics, Inc. 1997 Stock Option and Stock Purchase Plan; (Nonstatutory) with Cliff.                                                                                                                                                          |   | 10-Q   | 000-32501Exhibit 10.20   | 11/15/2004 |
|    |                                                                                                                                                                                                                                                                                                              |   |   |                     |       |
| 10.6#   | Notice and Agreement for Stock Options Grant Pursuant to Cytori Therapeutics, Inc. 1997 Stock Option and Stock Purchase Plan; (Incentive).                                                                                                                                                                        |   | 10-Q   | 000-32501Exhibit 10.21   | 11/15/2004 |
|    |                                                                                                                                                                                                                                                                                                              |   |   |                     |       |
| 10.7#   | Notice and Agreement for Stock Options Grant Pursuant to Cytori Therapeutics, Inc. 1997 Stock Option and Stock Purchase Plan; (Incentive) with Cliff.                                                                                                                                                             |   | 10-Q   | 000-32501Exhibit 10.22   | 11/15/2004 |
|    |                                                                                                                                                                                                                                                                                                              |   |   |                     |       |
| 10.8#   | Form of Options Exercise and Stock Purchase Agreement Relating to the 2004 Equity Incentive Plan.                                                                                                                                                                                                                 |   | 10-Q   | 000-32501Exhibit 10.23   | 11/15/2004 |
|    |                                                                                                                                                                                                                                                                                                              |   |   |                     |       |
| 10.9#   | Form of Notice of Stock Options Grant Relating to the 2004 Equity Incentive Plan.                                                                                                                                                                                                                                 |   | 10-Q   | 000-32501Exhibit 10.24   | 11/15/2004 |
|    |                                                                                                                                                                                                                                                                                                              |   |   |                     |       |
| 10.10   | Sublease Agreement dated May 24, 2005, between Biogen Idec, Inc. and the Company.                                                                                                                                                                                                                                 |   | 10-Q   | 000-32501Exhibit 10.21   | 08/15/2005 |
|    |                                                                                                                                                                                                                                                                                                              |   |   |                     |       |
| 10.11+  | License & Royalty Agreement, effective August 23, 2007, by and between Olympus-Cytori, Inc. and Cytori Therapeutics, Inc.                                                                                                                                                                                |   | 10-Q   | 000-32501Exhibit 10.49   | 11/13/2007 |
|    |                                                                                                                                                                                                                                                                                                              |   |   |                     |       |
| 10.69   | Lease Agreement entered into on April 2, 2010, between HCP Callan Rd, LLC. and Cytori Therapeutics, Inc.                                                                                                                                                                                                          |   | 10-Q   | 001-34375Exhibit 10.69   | 05/06/2010 |
|    |                                                                                                                                                                                                                                                                                                              |   |   |                     |       |
| 10.76   | Common Stock Purchase Agreement, dated December 6, 2010, by and among Cytori Therapeutics, Inc. and Astellas Pharma Inc.                                                                                                                                                                                          |   | 8-K    | 001-34375Exhibit 10.76   | 12/09/2010 |
|    |                                                                                                                                                                                                                                                                                                              |   |   |                     |       |
| 10.77   | Form of Notice and Restricted Stock Award Agreement for grants of performance-based restricted stock awards under the 2004 Equity Incentive Plan.                                                                                                                                                            |   | 8-K    | 001-34375Exhibit 10.1    | 03/04/2011 |

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| 10.88    | First Amendment to Lease Agreement entered into on November 4, 2011, between HCP Callan Rd, LLC. and the Company.                                                                                                                                                                               |   | 10-Q    | 001-34375Exhibit 10.88 | 11/08/2011      |
|----------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|--------|---------|------------------------|-----------------|
|     |                                                                                                                                                                                                                                                                                            |   |    |                   |            |
| 10.89#   | 2011 Employee Stock Purchase Plan                                                                                                                                                                                                                                                               |   | DEF 14A | 001-34375Appendix A    | 05/02/2011      |
|     |                                                                                                                                                                                                                                                                                            |   |    |                   |            |
| 10.90+   | Contract HHSO100201200008C dated September 27, 2012, by and between the Company and the U.S. Department of Health and Human Services Biomedical Advanced Research and Development Authority (portions of the exhibit have been omitted pursuant to a request for confidential treatment).  |   | 8-K     | 001-34375Exhibit 10.90 | 10/03/2012      |
|     |                                                                                                                                                                                                                                                                                            |   |    |                   |            |
| 10.91    | Joint Venture Termination Agreement dated May 8, 2013 by and between the Company and Olympus Corporation.                                                                                                                                                                                       |   | 10-Q    | 001-34375Exhibit 10.91 | 05/10/2013      |
|     |                                                                                                                                                                                                                                                                                            |   |    |                   |            |
| 10.93+   | Puregraft Sale-License-Supply Agreement, dated July 30, 2013, by and among the Company and Bimini Technologies LLC.                                                                                                                                                                             |   | 10-Q/A  | 001-34375Exhibit 10.93 | 11/12/2013      |
|     |                                                                                                                                                                                                                                                                                            |   |    |                   |            |
| 10.94+   | Amended and Restated License and Supply Agreement dated January 30, 2014, by and between the Company and Lorem Vascular Pty. Ltd.                                                                                                                                                               |   | 8-K     | 001-34375              | 02/04/2014      |
|     |                                                                                                                                                                                                                                                                                            |   |    |                   |            |
| 10.95    | Sales Agreement, dated May 12, 2014, by and between Cytori Therapeutics, Inc. and Cowen and Company, LLC.                                                                                                                                                                                       |   | 8-K     | 001-34375              | 05/12/2014      |
|     |                                                                                                                                                                                                                                                                                            |   |    |                   |            |
| 10.98    | Cytori Therapeutics, Inc. 2014 Equity Incentive Plan.                                                                                                                                                                                                                                           |   | DEF 14A | 001-34375              | 06/12/2014      |
|     |                                                                                                                                                                                                                                                                                            |   |    |                   |            |
| 10.99    | Contract HHSO100201200008C Amendment No. 1 dated August 13, 2014, by and between the Company and the U.S. Department of Health and Human Services Biomedical Advanced Research and Development Authority.                                                                                       |   | 8-K     | 001-34375              | 08/19/2014      |
|     |                                                                                                                                                                                                                                                                                            |   |    |                   |            |
| 10.103   | Confidential Separation Agreement and General Release of all claims dated October 2, 2014, by and among the Company, and Clyde Shores.                                                                                                                                                          |   | 10-Q    | 001-34375              | 11/06/2014      |
|     |                                                                                                                                                                                                                                                                                            |   |    |                   |            |
| 10.104   | Form of Securities Purchase Agreement by and between Cytori Therapeutics, Inc. and the Purchasers (as defined therein), dated as of October 8, 2014.                                                                                                                                            |   | 8-K     | 001-034375             | 10/08/2014      |
|     |                                                                                                                                                                                                                                                                                            |   |    |                   |            |
| 10.105   | Placement Agency Agreement, dated October 8, 2014, between Cytori Therapeutics, Inc. and Roth Capital Partners, LLC.                                                                                                                                                                            |   | 8-K     | 001-034375             | 10/08/2014      |
|     |                                                                                                                                                                                                                                                                                            |   |    |                   |            |
| 10.106   | Amendment One to the Securities Purchase Agreement, dated March 16, 2015, between the Company and certain institutional investors                                                                                                                                                               |   | 10-Q    | 001-034375             | 05/11/2015      |
|     |                                                                                                                                                                                                                                                                                            |   |    |                   |            |
| 1.107    | Form of Securities Purchase Agreement, dated May 5, 2015, by and among Cytori Therapeutics, Inc. and the investors named therein                                                                                                                                                                |   | 8-K     | 001-034375             | 05/05/2015      |
|     |                                                                                                                                                                                                                                                                                            |   |    |                   |            |
| 1.108    | Placement Agency Agreement, dated May 5, 2015, by and between Cytori Therapeutics, Inc. and Mizuho Securities USA Inc.                                                                                                                                                                          |   | 8-K     | 001-034375             | 05/05/2015      |
|     |                                                                                                                                                                                                                                                                                            |   |    |                   |            |
| 1.109    | Amendment One to Joint Venture Termination Agreement, dated April 30, 2015, by and between Cytori Therapeutics, Inc. and Olympus Corporation                                                                                                                                                    |   | 8-K     | 001-034375             | 05/05/2015      |
|     |                                                                                                                                                                                                                                                                                            |   |    |                   |            |
| 1.110    | Loan and Security Agreement, dated May 29, 2015, by and between Cytori Therapeutics, Inc. and Oxford Finance, LLC                                                                                                                                                                               |   | 10-Q    | 001-034375             | 08/10/2015      |
|     |                                                                                                                                                                                                                                                                                            |   |    |                   |            |
| 1.111**  | Amendment One to the Securities Purchase Agreement between the Company and certain institutional investors dated May 5, 2015                                                                                                                                                                    | X      |    |                   |            |
|     |                                                                                                                                                                                                                                                                                            |   |    |                   |            |
| 1,112#   | 2015 New Employee Incentive Plan                                                                                                                                                                                                                                                                |   | 8-K     | 001-034375             | January 5, 2016 |
|     |                                                                                                                                                                                                                                                                                            |   |    |                   |            |
| 1.113#** | Form of Agreement for Acceleration and/or Severance                                                                                                                                                                                                                                             | X      |    |                   |            |
|     |                                                                                                                                                                                                                                                                                            |   |    |                   |            |
| 23.1**   | Consent of KPMG LLP, Independent Registered Public Accounting Firm                                                                                                                                                                                                                              | X      |    |                   |            |
|     |                                                                                                                                                                                                                                                                                            |   |    |                   |            |
| 31.1     | Certification of Principal Executive Officer Pursuant to Securities Exchange Act Rule 13a-14(a), as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002                                                                                                                           | X      |    |                   |            |
|     |                                                                                                                                                                                                                                                                                            |   |    |                   |            |
| 31.2     | Certification of Principal Financial Officer Pursuant to Securities Exchange Act Rule 13a-14(a), as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002                                                                                                                           | X      |    |                   |            |

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| 32.1      | Certifications Pursuant to 18 U.S.C. Section 1350/ Securities Exchange Act Rule 13a-14(b), as adopted pursuant to Section 906 of the Sarbanes - Oxley Act of 2002 | X      |   |   |   |
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| 101.INS** | XBRL Instance Document                                                                                                                                            | X      |   |   |   |
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| 101.SCH** | XBRL Schema Document                                                                                                                                              | X      |   |   |   |
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| 101.CAL** | XBRL Calculation Linkbase Document                                                                                                                                | X      |   |   |   |
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| 101.DEF** | XBRL Definition Linkbase Document                                                                                                                                 | X      |   |   |   |
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| 101.LAB** | XBRL Label Linkbase Document                                                                                                                                      | X      |   |   |   |
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| **        | XBRL Presentation Linkbase Document                                                                                                                               | X      |   |   |   |