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Exhibit 21

List of Worldwide Subsidiaries of Angiotech Pharmaceuticals, Inc. as of March 12, 2009



Structure of ownership and control:

Angiotech Pharmaceuticals, Inc. wholly owns all of the below mentioned entities.



|                                                     |                             
|---------------------------------------------------- | ----------------------------
|Subsidiary Name                                      | Jurisdiction of Organization
|0741693 B.C. Ltd.                                    | British Columbia            
|0761717 B.C. Ltd.                                    | British Columbia            
|3091796 Nova Scotia Company                          | Nova Scotia                 
|3091798 Nova Scotia Company                          | Nova Scotia                 
|3091799 Nova Scotia Company                          | Nova Scotia                 
|Afmedica, Inc.                                       | Delaware                    
|American Medical Instruments Holdings, Inc.          | Delaware                    
|Angiodevice International GmbH                       | Switzerland                 
|Angiotech America, Inc.                              | Illinois                    
|Angiotech BioCoatings Corp. d/b/a Angiotech          | New York                    
|Angiotech Capital, LLC                               | Nevada                      
|Angiotech Danmark A/S                                | Denmark                     
|Angiotech Delaware, Inc.                             | Delaware                    
|Angiotech GmbH                                       | Germany                     
|Angiotech International AG                           | Switzerland                 
|Angiotech International Holdings, Corp.              | Nova Scotia                 
|Angiotech Investment Partnership                     | British Columbia            
|Angiotech Italy S.r.l.                               | Italy                       
|Angiotech Participações do Brasil Ltda.              | Brazil                      
|Angiotech Pharmaceuticals (US), Inc. d/b/a Angiotech | Washington                  
|Angiotech Pharmaceutical Interventions, Inc.         | Delaware                    
|Angiotech Puerto Rico, Inc.                          | Puerto Rico                 
|Angiotech SARL                                       | France                      
|Angiotech S.L.                                       | Spain                       
|Angiotech Switzerland SA                             | Switzerland                 
|Angiotech Tender Holdings, Inc.                      | British Columbia            
|Angiotech UK Ltd.                                    | United Kingdom              
|API Canada Holdings, Inc.                            | British Columbia            
|B.G. Sulzle, Inc. d/b/a Angiotech                    | Delaware                    
|Bifos AB                                             | Sweden                      
|Crimson Cardinal Capital, LLC                        | Nevada                      
|DOS Trust                                            | British Columbia            
|Manan Medical Products, Inc. d/b/a Angiotech         | Delaware                    
|Medical Device Technologies, Inc. d/b/a Angiotech    | Delaware                    
|NeuColl, Inc.                                        | Delaware                    
|PBN Medicals Denmark A/S                             | Denmark                     
|Pearsalls Development Limited                        | United Kingdom              
|Pearsalls Limited                                    | United Kingdom              
|Quill Medical, Inc.                                  | Delaware                    
|Soldiers Field Liquidity Management LLC              | Hungary                     
|Surgical Specialties Corporation d/b/a Angiotech     | Delaware                    
|Surgical Specialties Puerto Rico, Inc.               | Puerto Rico                 
|Surgical Specialties UK Holdings Limited             | United Kingdom              





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