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Dimethyl-1,2-dibromo-2,2-dichlorethyl phosphate (Naled)																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 300–76–5
**NIOSH REL:** 3 mg/m3 TWA [skin]
**Current OSHA PEL:** 3 mg/m3 TWA
**1989 OSHA PEL:** 3 mg/m3 TWA [skin]
**1993-1994 ACGIH TLV:** 3 mg/m3 TWA [skin]
**Description of Substance:** Colorless to white solid or straw-colored liquid (above 80 F) with a slightly pungent odor.
**LEL:**. . Noncombustible Solid
**Original (SCP) IDLH:** 1,800 mg/m3
**Basis for original (SCP) IDLH:** Because no useful data on acute inhalation toxicity are available, the chosen IDLH has been estimated from the male rat oral LD50 of 250 mg/kg [Gaines 1969 cited by ACGIH 1971]. ACGIH [1971] also reported that the acute toxicity data, inhalation data, and experience to date indicate that this is not a highly dangerous material.
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA**
**Lethal dose data:**

**Species**
    **Reference**
    **Route**
    **LD50** **(mg/kg)**
    **LDLo** **(mg/kg)**
    **Adjusted LD**
    **Derived value**Mouse MouseRatMammalRatMouse
    Berteau and Deen 1978 Berteau and Deen 1978Berteau and Deen 1978Debska et al. 1975Gaines 1969Haley et al. 1975
    inhalation*oraloraloraloraloral
    156 222160430250330
    ----- -------------------------
    1,092 mg/m31,554 mg/m31,120 mg/m33,010 mg/m31,750 mg/m32,310 mg/m3
    109 mg/m3155 mg/m3112 mg/m3301 mg/m3175 mg/m3231 mg/m3*Note: An inhalation exposure that was presented as "mg/kg."
 **Human data:** None relevant for use in determining the revised IDLH.
 
 **Revised IDLH:** 200 mg/m3**Basis for revised IDLH:** The revised IDLH for dimethyl-1,2-dibromo-2,2-dichlorethyl phosphate is 200 mg/m3 based on acute toxicity data in animals [Berteau and Deen 1978, Debska et al. 1975; Gaines 1969; Haley et al. 1975].
**REFERENCES:**
1. ACGIH [1971]. Dibrom (naled). In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 73.
2. Berteau P, Deen W [1978]. A comparison of oral and inhalation toxicities of four insecticides to mice and rats. Bulletin Environ Contam Toxicol *19*:113-120.
3. Debska W, Jaruzelski M, Witkowski W, Zdziechowski J [1975]. Dynamika zanikania pestycydow w roslinach leczniczych. Herba Polonica *21*:53-60 (in Polish).
4. Gaines TB [1969]. Acute toxicity of pesticides. Toxicol Appl Pharmacol *14*:515-534.
5. Haley TJ, Farmer JH, Harmon JR, Dooley KL [1975]. Estimation of the LD1 and extrapolation of the LD0.1 for five organophosphate pesticides. Arch Toxicol *34*:103-109.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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