Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link


Centers for Disease Control and Prevention. CDC twenty four seven. Saving Lives, Protecting People
					Search
		×
			NIOSH
			NIOSH
				All CDC
				Submit
			For a full list of topics:A-Z Index
			Advanced Search
		Advanced Search


The National Institute for Occupational Safety and Health (NIOSH)


Facebook
        Twitter
        LinkedIn
        Syndicate





tert-Butyl alcohol																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 75–65–0
**NIOSH REL:** 100 ppm (300 mg/m3) TWA, 150 ppm (450 mg/m3) STEL
**Current OSHA PEL:** 100 ppm (300 mg/m3) TWA
**1989 OSHA PEL:** 100 ppm (300 mg/m3) TWA, 150 ppm (450 mg/m3) STEL
**1993-1994 ACGIH TLV:** 100 ppm (303 mg/m3) TWA
**Description of Substance:** Colorless solid or liquid (above 77 F) with a camphor-like odor.
**LEL:** . . 2.4% (10% LEL, 2,400 ppm)
**Original (SCP) IDLH:** 8,000 ppm
**Basis for original (SCP) IDLH:** No data on acute inhalation toxicity are available on which to base the IDLH for tert-butyl alcohol, but Patty [1963] reported that the signs of intoxication on the part of animals exposed to its vapors are similar to those induced by the other butyl alcohols [Weese 1928]. For this draft technical standard, therefore, the IDLH is based on an analogy with isobutyl alcohol and n-butyl alcohol, which have IDLHs of 8,000 ppm.
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA**
**Lethal dose data:**

**Species**
    **Reference**
    **Route**
    **LD50** **(mg/kg)**
    **LDLo** **(mg/kg)**
    **Adjusted LD**
    **Derived value**Rabbit Rat
    Munch 1972 Schaffarzick and Brown 1952
    oral oral
    3,559 3,500
    ----- -----
    8,089 ppm 7,955 ppm
    809 ppm 796 ppm
 **Other animal data:** It has been reported that inhalation toxicity for tert-butyl alcohol is similar to that induced by the other butyl alcohols [Weese 1928].
 **Human data:** None relevant for use in determining the revised IDLH.
 
 **Revised IDLH:** 1,600 ppm **Basis for revised IDLH:** The revised IDLH for tert-butyl alcohol is 1,600 ppm based on analogies [Weese 1928] to isobutyl alcohol and n-butyl alcohol.
**REFERENCES:**
1. Munch JC [1972]. Aliphatic alcohols and alkyl esters: narcotic and lethal potencies to tadpoles and to rabbits. Ind Med Surg *41*:31-33.
2. Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 1447.
3. Schaffarzick RW, Brown BJ [1952]. The anticonvulsant activity and toxicity of methylparafynol (Dormison®) and some other alcohols. Science *116*:663-665.
4. Weese H [1928]. Comparative studies of the effect of toxicity of lower aliphatic alcohol vapors (translated). Arch Exp Pathol Pharmakol *135*:121-123.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
Pinterest
Twitter
YouTube
 NIOSH Homepage NIOSH A-Z
Workplace Safety & Health Topics
Publications and Products
Programs
Contact NIOSH


About CDC
					Contact Us
					800-232-4636
 Facebook Twitter Instagram LinkedIn Youtube Pinterest Snapchat
 CONTACT CDC
				Contact Us
							Call 800-232-4636
							Email Us
			ABOUT CDC
				About CDC
							Jobs
							Funding
			POLICIES
				Accessibility
							External Links
							Privacy
							Policies
							No Fear Act
							FOIA
							OIG
							Nondiscrimination
							Vulnerability Disclosure Policy
			CONNECT WITH US
				Facebook
								Twitter
								Instagram
								LinkedIn
							Youtube
								Pinterest
								Snapchat
								Email
			LANGUAGES
				Español
							繁體中文
							Tiếng Việt
							한국어
							Tagalog
							Русский
							العربية
							Kreyòl Ayisyen
							Français
							Polski
							Português
							Italiano
							Deutsch
							日本語
							فارسی
							English


U.S. Department of Health & Human Services
			Accessibility
			External Links
			Privacy
			Policies
			No Fear Act
			FOIA
			Nondiscrimination
			OIG
			Vulnerability Disclosure Policy
			USA.gov


Exit Notification/Disclaimer Policy Close
 Links with this icon  indicate that you are leaving the CDC website. The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website.
					Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website.
					You will be subject to the destination website's privacy policy when you follow the link.
					CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website. Website Disclaimers
 Cancel Continue