Exhibit 4.24


 


CONVERTIBLE
LOAN AGREEMENT


 


This
Convertible Loan Agreement (this “Agreement”) is dated as of August __, 2019, between CollPlant Biotechnologies
Ltd., a company organized under the laws of the State of Israel (the “Company”), and Ami Sagi, bearer of Israeli
I.D. No.  _____ (including his successors and assigns, the “Lender”).


 


WHEREAS,
the Company requires an immediate infusion of funds to support its ongoing operations; and


 


WHEREAS, Lender is willing
to make available to the Company, and the Company has agreed to accept from Lender, a loan in an aggregate principal amount of
Three Million United States Dollars ($3,000,000) that shall be extended to the Company in two tranches, and which may be automatically
converted into ADSs (as defined below), all subject to and in accordance with the terms and conditions of this Agreement.


 


NOW,
THEREFORE, in consideration of the mutual covenants contained in this Agreement, and for other good and valuable consideration,
the receipt and adequacy of which are hereby acknowledged, the Company and the Lender agree as follows:


 


DEFINITIONS


 


	1.1.	Definitions.



 


In
addition to the terms defined elsewhere in this Agreement, the following terms have the meanings set forth in this Section ‎1.1:


 


“Action”
means any action, suit, inquiry, notice of violation, proceeding or investigation pending or, to the knowledge of the Company,
threatened against or affecting the Company, its Subsidiary or any of their respective properties before or by any court, arbitrator,
governmental or administrative agency or regulatory authority (federal, state, county, local or foreign).


 


“ADS(s)”
means American Depositary Shares issued pursuant to the Deposit Agreement (as defined below), each representing a number of Ordinary
Shares as set forth in the Deposit Agreement.


 


“Affiliate”
means any Person that, directly or indirectly through one or more intermediaries, controls or is controlled by or is under common
control with a Person, as such terms are used in and construed under Rule 405 under the Securities Act.


 


“BNY
Mellon” means The Bank of New York Mellon, the depositary for the ADSs.


 


“Board
of Directors” means the board of directors of the Company.


 


“Business
Day” means any day except any Friday, Saturday, Sunday, and any day which is a federal legal holiday in the United States
or any day on which banking institutions in the State of New York and Israel are authorized or required by law or other governmental
action to close.


 






     


     


    

 


“Closings”
means the First Closing, the Second Closing and the Third Closing, as applicable.


 


“Closing
Date” means the First Closing Date, the Second Closing Date and the Third Closing Date, as applicable.


 


“Conversion
ADSs” means the ADSs representing the Conversion Shares.


 


“Conversion
Price” shall have the meaning ascribed to in Section ‎2.5.1.


 


“Conversion
Shares” means the Ordinary Shares issued and issuable upon conversion of the First Principal Amount and the Second Principal
Amount (to the extent applicable).


 


“Deposit
Agreement” means the deposit agreement, dated March 3, 2015, amended and restated as of January 30, 2018, among the Company,
BNY Mellon as depositary and the owners and holders of ADSs from time to time, as such agreement may be amended or supplemented.


 


“Exchange
Act” means the Securities Exchange Act of 1934, as amended, and the rules and regulations promulgated thereunder.


 


“Exempt
Issuance” means the issuance of (a) ADSs, Ordinary Shares or options (including bonus shares) to employees, officers,
directors or advisors of the Company or its Subsidiaries pursuant to any existing or future stock or option plan or arrangement
duly adopted for such purpose by the Board of Directors or a majority of the members of a committee of non-employee directors
established for such purpose for services rendered to the Company or its Subsidiaries (including any exercise of options into
Ordinary Shares or ADSs pursuant to such plan or arrangement), provided that issuances to advisors under this clause (a) shall
not exceed an aggregate of above-market options exercisable into more than 100,000 Ordinary Shares (subject to adjustment for
reverse and forward stock splits, recapitalizations and similar transactions after the date hereof) in any twelve (12) month period,
(b) securities upon the exercise or exchange of or conversion of any Securities issued or issuable hereunder and/or other securities
exercisable or exchangeable for or convertible into ADSs or Ordinary Shares issued and outstanding on the date of this Agreement
pursuant to their terms, provided that such securities have not been amended since the date of this Agreement to increase the
number of such securities or to decrease the exercise price, exchange price or conversion price of such securities (other than
in connection with share splits, combinations, dividends, distributions and other similar transactions) or to extend the term
of such securities, and (c) securities issued pursuant to rights offering to all of the Company’s shareholders, (d) securities
issued in connection with any pro rata stock split, distributions, dividends, combinations or similar events effecting all holders
of Ordinary Shares and (e) securities issued as consideration in acquisitions or strategic transactions approved by a majority
of the Board of Directors of the Company, provided that such securities are issued as “restricted securities” (as defined
in Rule 144).


 


“First
Closing” - shall have the meaning ascribed to such term in Section ‎2.1.1.


 


“First
Closing Date” means the date of execution of this Agreement, subject to transfer of the First Principal Amount by Lender
to the Company.


 






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“First
Principal Amount” shall have the meaning ascribed to such term in Section 2.1.1.


 


“IFRS”
shall have the meaning ascribed to such term in Section 3.1.6.


 


“Interest”
shall have the meaning ascribed to such term in Section 2.1.1.


 


“Israeli
Companies Law” means the Israeli Companies Law, 1999, and the regulations and orders promulgated thereunder.


 


“Israeli
Securities Law” means the Israeli Securities Law, 1968, and the regulations and orders promulgated thereunder.


 


“Loan”
means the Principal and the Interest accrued thereon.


 


“Liens”
means a lien, charge, pledge, security interest, encumbrance, right of first refusal, preemptive right or other restriction.


 


“Ordinary
Share(s)” means the ordinary shares of the Company, par value ILS 1.50 per share.


 


“Ordinary
Share Equivalents” means any securities of the Company or the Subsidiary which would entitle the holder thereof to acquire
at any time Ordinary Shares or ADSs, including, without limitation, any debt, preferred stock, right, option, warrant or other
instrument that is at any time convertible into or exercisable or exchangeable for, or otherwise entitles the holder thereof to
receive, Ordinary Shares or ADSs.


 


“Per
Ordinary Share Price” equals US $4.00, subject to adjustment for reverse and forward share splits, share dividends, share
combinations and other similar transactions of the Ordinary Shares that occur after the date of this Agreement.


 


“Person”
means an individual or corporation, partnership, trust, incorporated or unincorporated association, joint venture, limited liability
company, joint stock company, government (or an agency or subdivision thereof) or other entity of any kind.


 


“Principal”
means the First Principal Amount and the Second Principal Amount, to the extent applicable.


 


“Proceeding”
means an action, claim, suit, investigation or proceeding (including, without limitation, an informal investigation or partial
proceeding, such as a deposition), whether commenced or threatened.


 


“SEC
Documents” shall have the meaning ascribed to such term in Section 3.1.6.


 


“Second
Closing” - shall have the meaning ascribed to such term in Section ‎2.1.2.


 


“Second
Closing Date” means the third (3rd) Business Day following the fulfillment of all the conditions precedent
to the Second Closing as set forth in Section ‎2.8.


 


“Second
Closing Warrant” means the Warrant of the Company in the form of Exhibit A attached hereto registered in the name
of the Lender to purchase up to 250,000 Warrant ADSs, with an exercise price equal to $4.00 per ADS.


 






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“Second
Principal Amount” shall have the meaning ascribed to such term in Section ‎2.1.2.


 


“Securities”
means the Conversion ADSs, the Second Closing Warrant and the Third Closing Warrant and the Warrant ADSs.


 


“Securities
Act” means the Securities Act of 1933, as amended, and the rules and regulations promulgated thereunder.


 


“Subsidiary”
means CollPlant Ltd.


 


“Third
Closing” shall have the meaning ascribed to such term in Section ‎2.1.3.


 


“Third
Closing Date” means the third (3rd) Business Day following the fulfillment of all the conditions precedent
to the Third Closing as set forth in Section 2.8.


 


“Third
Closing Warrant” means the Warrant of the Company in the form of Exhibit A attached hereto registered in the name
of the Lender to purchase up to 500,000 Warrant ADSs, with an exercise price equal to $4.00 per ADS.


 


“USD”
or “US $” or “$” means United States Dollar.


 


“Warrant
ADSs” means the ADSs issuable upon exercise of each of the Second Closing Warrant and the Third Closing Warrant, as applicable.


 


THE
LOAN


 


	2.1.	Closings



 


		2.1.1.	First
Closing. On the First Closing Date, upon the terms and subject to the conditions set forth herein the Lender shall transfer
to the Company a Two Million United States Dollars ($2,000,000) loan (the “First Principal Amount”) via a wire
transfer, or by such other form of payment as may be mutually agreed upon by the parties (the “First Closing”).




	 	2.1.2.	Second Closing. On the Second Closing Date, upon
the terms and subject to the conditions set forth herein: (i) the Lender shall transfer to the Company a One Million United States
Dollars ($1,000,000) loan (the “Second Principal Amount”), via a wire transfer, or by such other form of payment
as may be mutually agreed upon by the Company and the Lender; and (ii) only if the Second Closing shall occur after the Third
Closing Date, the Company shall grant the Lender the Second Closing Warrant (the “Second Closing”).
	 	 	 
	 	2.1.3.	Third
Closing. On the Third Closing Date, upon the terms and subject to the conditions set forth herein: (i) the First Principal
Amount and the Second Principal Amount (to the extent applicable) shall be converted into ADSs, all in accordance with Section
2.5; (ii) the Company shall grant the Lender the Third Closing Warrant; and (iii) if the Second Closing shall have occurred prior
to the Third Closing Date, the Company shall grant the Lender the Second Closing Warrant (the “Third Closing”).
	 	 	 
	 	2.1.4.	For the
avoidance of doubt, it is clarified that should the Third Closing be consummated before the Second Closing, the Second Closing
shall be conducted by way of an equity investment in the Company and not by way of a convertible loan and the Second Principal
Amount shall have been deemed to be converted into the Conversion ADSs pursuant to Section 2.5.



 






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	2.2.	The Loan.




 


	 	2.2.1.	Interest. The Principal shall bear an interest
at a rate of 6% per annum (calculated on the actual number of days elapsed from the actual extension of the respective portion
of the Principal and a year of 365 days) (the “Interest”). The Interest shall be accrued on the respective
portion of the First Principal Amount or the Second Principal Amount and paid in cash by the Company to the Lender on a quarterly
basis as of the First Closing Date or the Second Closing Date, as applicable, in arrears, or earlier in accordance with Sections
‎2.3, ‎2.4 and ‎2.5.1.




 


	 	2.2.2.	Maturity. Subject to the provisions of Sections
‎2.3, ‎2.4 and ‎2.5.1, the First Principal Amount and the Second Principal Amount shall be repaid in cash in one installment
(“bullet”) by the Company to Lender upon the lapse of three years from the First Closing Date or the Second
Closing Date, respectively. Upon repayment of the Loan (including by way of early repayment or immediate repayment as set forth
below), the Loan shall be duly and fully repaid and discharged.




 


	2.3.	Early Repayment.




 


The
Company shall be entitled, at any time and in its sole judgement, to early prepay the Loan, in whole or in part, without any fine
and/or penalty.


 


	2.4.	Immediate Repayment.




 


Notwithstanding
the aforesaid, the outstanding Loan shall immediately become due and payable in cash by the Company upon the occurrence of the
earlier of the following events, if so requested to be repaid at the Lender’s election:


 


	 	2.4.1.	The Company files any petition or action for relief under any bankruptcy, reorganization, insolvency or moratorium law or any
other law for the relief of, or relating to, debtors, now or hereafter in effect (collectively, “Bankruptcy Laws”),
or makes any assignment for the benefit of creditors or takes any corporate action in furtherance of any of the foregoing;




 


	 	2.4.2.	The calling by the Company of a meeting of creditors
for the purpose of entering into a scheme or arrangement with them; and




 


	 	2.4.3.	The Company adopts one or more resolutions for dissolution,
liquidation, bankruptcy, or reorganization or winding-up of the Company.




 


	 	2.4.4.	The Company defaults in its performance of any of its
material obligations under this Agreement (including any Exhibits, Schedules or Annexes hereto), which default is not cured (if
curable) within thirty (30) days after written notice of such default is received by the Company from the Lender.




 






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	2.5.	Automatic Conversion.




 


	 	2.5.1.	Automatic Conversion. Subject to the satisfaction
of the Condition for Automatic Conversion (as defined below), on the Third Closing Date the outstanding Principal on such date
shall automatically convert into the Conversion ADSs (the “Automatic Conversion”) at a conversion price equal
to $4.00 per one ADS (the “Conversion Price”) and the Company shall pay the Lender the Interest accrued on the
converted Principal in cash. Upon such conversion, the Loan shall be deemed to be duly and fully repaid and discharged.




 


	 	2.5.2.	No Fractional ADSs. No fractional ADSs shall
be issued to the Lender, and the number of Conversion ADSs shall be rounded to the nearest whole ADS.




 


	 	2.5.3.	Conversion ADSs. The Lender hereby undertakes
to execute any document as shall be required by the Company in connection with the issuance of the Conversion ADSs.




 


	 	2.5.4.	Rights as Shareholder. From the Third Closing
Date, the Lender shall be deemed to be the holder of the Conversion ADSs, and shall be deemed to have all rights, preferences,
powers, privileges, restrictions, qualifications and limitations required to be granted in connection with the Conversion ADSs.




 


	 	2.5.5.	Due Issuance. Upon the consummation of the Automatic
Conversion, the Conversion ADSs to be issued pursuant to such conversion shall be duly authorized, validly issued, fully-paid,
non-assessable and free and clear of any restrictions on transfer and of any pre-emptive rights, pledges, Liens, claims, encumbrances
or third party rights of any kind.




 


	2.6.	Additional Protections.




 


	 	2.6.1.	Adjustments. The number of Conversion ADSs shall
be subject to adjustments in the following events: (a) distribution of stock dividend or bonus shares prior to such conversion,
in which event the number of Conversion ADSs the Lender is entitled to pursuant to such conversion shall be increased, for no
consideration, by the number of ADSs such Lender would have been entitled to pursuant to such conversion had the conversion occurred
immediately prior to such distribution; and (b) stock split, subdivision, or combination of the Company’s share capital,
in which event the number of Conversion ADSs issuable to the Lender pursuant to such conversion shall be proportionally increased
or decreased, as the case may be.




 






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	 	2.6.2.	Subsequent Equity Sales. Until the three (3)
year anniversary of the First Closing Date, and so long as the Principal has not been converted into the Conversion ADSs pursuant
to Section ‎2.5, if the Company sells or grants any option to purchase or sells or grants any right to reprice, or otherwise
disposes of or issues any ADSs, Ordinary Shares or Ordinary Share Equivalents entitling any Person to acquire ADSs or Ordinary
Shares at an effective consideration paid for the securities that is lower than the Conversion Price (calculated per Ordinary
Share) (in this Section ‎2.6.2, such lower price, the “Base Conversion Price” and such issuances, collectively,
a “Dilutive Issuance”), then the Conversion Price shall be reduced to equal the Base Conversion Price. Such adjustment
shall be made whenever such ADSs, Ordinary Shares or Ordinary Share Equivalents are issued. Notwithstanding the foregoing, no
adjustment will be made under this Section 2.6.2in respect of an Exempt Issuance. The Company shall notify the Lender in writing,
no later than the Business Day following the issuance of any ADSs, Ordinary Shares or Ordinary Share Equivalents subject to this
Section 2.6.2, indicating therein the applicable issuance price, or applicable reset price, exchange price, conversion price and
other pricing terms (such notice, the “Dilutive Issuance Notice”). For purposes of clarification, whether or
not the Company provides a Dilutive Issuance Notice pursuant to this Section 2.6.2, upon the occurrence of any Dilutive Issuance,
the Lender is entitled to receive a number of Conversion ADSs based upon the Base Conversion Price on or after the date of such
Dilutive Issuance, regardless of whether the Lender accurately refers to the Base Conversion Price in the Notice of Conversion.




 


	2.7.	Deliveries.




 


	 	2.7.1.	On or prior to each Closing Date (except as otherwise
indicated), the Company shall deliver or cause to be delivered to the Lender the following:




 


	 	(a)	As to the First Closing Date, this Agreement duly executed
by the Company;




 


	 	(b)	As to the First Closing Date and the Second Closing
Date, the Company shall have provided the Lender with the Company’s wire instructions;




 


	 	(c)	as to the First Closing Date, the Registration Rights
Agreement attached hereto as Exhibit B, duly executed by the Company;




 


	 	(d)	As to the Second Closing Date (if the Second Closing
Date shall occur after the Third Closing Date) and the Third Closing Date, the Company’s instructions to its share register
to issue such number of Ordinary Shares underlying the Conversion ADSs to the account of the BNY Mellon, and instructing the BNY
Mellon to deposit the Conversion ADSs to the Lender’s account (as provided by such Lender pursuant to Section 2.7.2(e));




 


	 	(e)	As to the Third Closing Date, the Company shall have
provided the Lender with the Price Protection Agreement attached hereto as Exhibit C, duly executed by the Company;




 


	 	(f)	As to the Third Closing Date, the Third Closing Warrant
duly executed by the Company; and




 


	 	(g)	As to the Second Closing Date, only if the Second Closing
Date shall occur after the Third Closing Date, the Second Closing Warrant duly executed by the Company.




 






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	 	2.7.2.	On or prior to each Closing Date the Lender shall deliver
or cause to be delivered to the Company the following:




 


	 	(a)	As to the First Closing Date, this Agreement duly executed
by the Lender;




 


	 	(b)	As to the First Closing Date and the Second Closing
Date, the First Principal Amount and the Second Principal Amount, respectively, by a wire transfer to the account specified in
writing by the Company;




 


	 	(c)	As to the First Closing Date, the Registration Rights
Agreement duly executed by the Lender;




 


	 	(d)	As to the Third Closing Date, the Lender shall have
provided the Company with the Price Protection Agreement attached hereto as Exhibit C, duly executed by Lender; and




 


	 	(e)	As to the Third Closing Date and the Second Closing
Date (if the Second Closing Date shall occur after the Third Closing Date), the full details required by BNY Mellon (in accordance
with the Company’s instructions) in order for BNY Mellon to be able to deposit the Conversion ADSs for the benefit of the Lender.




 


All
actions to be taken and all documents to be executed and delivered by any party hereto at each of the Closing Dates shall be deemed
to have been taken and executed and delivered simultaneously, and no action shall be deemed taken nor any document executed or
delivered until all have been taken, executed and delivered.


 


	2.8.	Second and Third Closing Conditions.




 


The
obligations of each of the parties hereunder in connection with the Second Closing and the Third Closing are subject to the following
conditions being met:


 


	 	2.8.1.	with respect to the Second Closing, prior to the Second
Closing Date, the Company shall have executed a license and/or a co-development agreement with Allergan Plc or any of its Affiliates
with respect to the Company’s intellectual property.




 


	 	2.8.2.	with respect to the Third Closing, prior to the Third
Closing Date, the Company shall have received the approval of its shareholders in accordance with Section 328(b) of the Companies
Law for the transactions contemplated by this Agreement (for a holding by Lender of voting rights in the Company that are equal
to or exceeding 25% of the voting rights in the Company) and in accordance with Section 275 of the Companies Law for the consummation
of the Second Closing and Third Closing as well as for the implementation of existing anti-dilution undertakings of the Company
towards Lender, Alpha Capital Anstalt and Meitav Dash Provident Funds and Pension Ltd. (the “Condition for Automatic Conversion”).




 






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REPRESENTATIONS
AND WARRANTIES


 


	3.1.	Representations and Warranties of the Company.




 


The
Company hereby makes the following representations and warranties to the Lender:


 


	 	3.1.1.	Organization and Qualification. The Company and
its Subsidiary are entities duly incorporated and validly existing under the laws of the State of Israel, with the requisite power
and authority to own and use their properties and assets and to carry on its business as currently conducted. Neither the Company
nor its Subsidiary is in violation nor default of any of the provisions of its respective memorandum and articles of association.
Each of the Company and its Subsidiary is duly qualified to conduct business in each jurisdiction in which the nature of the business
conducted or property owned by it makes such qualification necessary, except where the failure to be so qualified, would not have
or reasonably be expected to result in: (i) a material adverse effect on the legality, validity or enforceability of the Agreement,
or (ii) a material adverse effect on the Company’s ability to perform in any material respect on a timely basis its obligations
under this Agreement and no Proceeding has been instituted in any such jurisdiction revoking, limiting or curtailing or seeking
to revoke, limit or curtail such power and authority or qualification.




 


	 	3.1.2.	Authorization; Enforcement. Subject to the conditions
to each of the Closings as set forth in Section 2.8, (i) the Company has the requisite corporate power and authority to enter
into and to consummate the transactions contemplated by this Agreement and otherwise to carry out its obligations hereunder and
thereunder; (ii) the execution and delivery of this Agreement by the Company and the consummation by it of the transactions contemplated
hereby and thereby have been duly authorized by all necessary action on the part of the Company and no further action is required
by the Company or the Board of Directors in connection herewith or therewith. This Agreement has been (or upon delivery will have
been) duly executed by the Company and, when delivered in accordance with the terms hereof and thereof, will constitute the valid
and binding obligation of the Company enforceable against the Company in accordance with its terms, except: (i) subject to the
conditions to each of the Closings as set forth in Section 2.8; (ii) as limited by general equitable principles and applicable
bankruptcy, insolvency, reorganization, moratorium and other laws of general application affecting enforcement of creditors’
rights generally, and (iii) as limited by laws relating to the availability of specific performance, injunctive relief or other
equitable remedies.




 


	 	3.1.3.	No Conflicts. The execution, delivery and performance
by the Company of this Agreement do not and will not: (i) conflict with or violate any provision of the Company’s or its
Subsidiary’s memorandum or articles of association, or (ii) conflict with, or constitute a default (or an event that with notice
or lapse of time or both would become a default) under, result in the creation of any Lien upon any of the properties or assets
of the Company or its Subsidiary, or give to others any rights of termination, amendment, acceleration or cancellation (with or
without notice, lapse of time or both) of, any agreement, credit facility, debt or other instrument (evidencing a Company or its
Subsidiary debt or otherwise) or other understanding to which the Company or its Subsidiary is a party or by which any property
or asset of the Company or its Subsidiary is bound or affected, or (iii) conflict with or result in a violation of any law, rule,
regulation, order, judgment, injunction, decree or other restriction of any court or governmental authority to which the Company
or its Subsidiary is subject (including federal and state securities laws and regulations), or by which any property or asset
of the Company is bound or affected; except in the case of each of clauses (ii) and (iii), such as would not have or reasonably
be expected to result in a material adverse effect.




 






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	 	3.1.4.	Issuance of the Securities. If and when issued
and paid for in accordance with this Agreement, the Securities will be duly authorized and will be duly and validly issued, fully
paid and nonassessable, free and clear of all Liens imposed by the Company other than restrictions on exercise or transfer provided
for in this Agreement.




 


	 	3.1.5.	Capitalization. The capitalization of the Company
is as set forth on Schedule 3.1.5, which Schedule 3.1.5 shall also include the number of Ordinary Shares owned beneficially,
and of record, by Affiliates of the Company, to the Company’s knowledge, as of the date hereof. No Person has any right of first
refusal, preemptive right, right of participation, or any similar right to participate in the transactions contemplated by the
Agreement, other than as set forth in Schedule 3.1.5. Except as a result of the issuance of the Securities (if and when
issued) or as set forth on Schedule 3.1.5, there are no outstanding options, warrants, scrip rights to subscribe to, calls
or commitments of any character whatsoever relating to, or securities, rights or obligations convertible into or exercisable or
exchangeable for, or giving any Person any right to subscribe for or acquire any Ordinary Shares or the capital stock of the Subsidiary,
or contracts, commitments, understandings or arrangements by which the Company or the Subsidiary is or may become bound to issue
additional Ordinary Shares or Ordinary Share Equivalents or capital stock of the Subsidiary. Other than as set forth in Schedule
3.1.5, the issuance of the Securities (if and when issued) will not obligate the Company or the Subsidiary to issue Ordinary
Shares or other securities to any Person (other than the Lender) and will not result in a right of any holder of Company securities
to adjust the exercise, conversion, exchange or reset price under any of such securities. There are no outstanding securities
or instruments of the Company or any Subsidiary that contain any redemption or similar provisions, and there are no contracts,
commitments, understandings or arrangements by which the Company or any Subsidiary is or may become bound to redeem a security
of the Company or such Subsidiary. The Company does not have any stock appreciation rights or “phantom stock” plans
or agreements or any similar plan or agreement. All of the outstanding shares of capital stock of the Company are duly authorized,
validly issued, fully paid and nonassessable, have been issued in compliance with the Israeli Companies Law and the Israeli Securities
Law and, if applicable, all federal and state securities laws, and none of such outstanding shares was issued in violation of
any preemptive rights or similar rights to subscribe for or purchase securities. There are no shareholders agreements, voting
agreements or other similar agreements with respect to the Company’s issued share capital to which the Company is a party
or, to the knowledge of the Company, between or among any of the Company’s shareholders.




 






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	 	3.1.6.	SEC Documents; Financial Statements. The Company
has timely filed or furnished, as applicable, all reports, schedules, forms, statements and other documents required to be filed
or furnished by it with the SEC pursuant to the reporting requirements of Securities Act of 1933, as amended (the “Securities
Act”) and the Exchange Act, as applicable (all of the foregoing filed or furnished prior to the date hereof and all
exhibits included therein and financial statements and documents incorporated by reference therein being hereinafter referred
to as the “SEC Documents”). As of their respective dates, the SEC Documents complied in all material respects
with the requirements of the Securities Act and the Exchange Act. as applicable, and the rules and regulations of the SEC promulgated
thereunder applicable to the SEC Documents, and none of the SEC Documents, at the time they were filed or furnished with the SEC,
contained any untrue statement of a material fact or omitted to state a material fact required to be stated therein or necessary
in order to make the statements therein, in the light of the circumstances under which they were made, not misleading. As of their
respective dates, the financial statements of the Company included in the SEC Documents complied in all material respects with
applicable accounting requirements and the published rules and regulations of the SEC with respect thereto as in effect as of
the time of filing. Such financial statements have been prepared in accordance with International Financial Reporting Standards
as issued by the International Accounting Standards Board (“IFRS”), consistently applied, during the periods
involved (except (i) as may be otherwise indicated in such financial statements or the notes thereto or (ii) in the case of unaudited
interim statements, to the extent they may exclude footnotes or may be condensed or summary statements) and fairly present in
all material respects the financial position of the Company as of the dates thereof and the results of its operations and cash
flows for the periods then ended (subject, in the case of unaudited statements, to normal year-end audit adjustments which will
not be material, either individually or in the aggregate).




 


	3.2.	Representations and Warranties of the Lender.




 


The
Lender hereby represents and warrants as of the date hereof to the Company as follows (unless as of a specific date therein, in
which case they shall be accurate as of such date):


 


	 	3.2.1.	Authority. The Lender is not limited in any way
from entering into and consummating the transaction contemplated by this Agreement and otherwise carrying out its obligations
hereunder and thereunder. This Agreement has been duly executed by the Lender and will constitute the valid and legally binding
obligation of the Lender, enforceable against him in accordance with its terms, except: (i) as limited by general equitable principles
and applicable bankruptcy, insolvency, reorganization, moratorium and other laws of general application affecting enforcement
of creditors’ rights generally, (ii) as limited by laws relating to the availability of specific performance, injunctive
relief or other equitable remedies and (iii) insofar as indemnification and contribution provisions may be limited by applicable
law.




 






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	 	3.2.2.	Own Account. The Lender understands that the
Securities that may be issued to the Lender pursuant to this Agreement are “restricted securities” and have not been
registered under the Securities Act or any applicable state securities law and Lender will receive the Securities (to the extent
applicable) as principal for his own account and not with a view to or for distributing or reselling such Securities or any part
thereof in violation of the Securities Act or any applicable state securities law, has no present intention of distributing any
of such Securities in violation of the Securities Act or any applicable state securities law and has no direct or indirect arrangement
or understandings with any other Persons to distribute or regarding the distribution of such Securities in violation of the Securities
Act or any applicable state securities law (this representation and warranty not limiting the Lender’s right to sell the
Securities in compliance with applicable federal and state securities laws). The Lender understands that the Securities (to the
extent issued) may not be offered for sale, sold, assigned or transferred other than (i) outside of the United States accordance
with Rule 904 under the Securities Act, (ii) pursuant to an exemption from the registration requirements under the Securities
Act, or (iii) pursuant to an effective registration statement under the Securities Act, in each case in compliance with all applicable
state securities laws and the securities laws of any other jurisdiction applicable to such sale, assignment or transfer.




 


	 	3.2.3.	Classified Investor Lender Status. The Lender
is an investor listed in the first supplement of the Israeli Securities Law and is aware of the implications of the status of
being a Classified Investor specified in the First Supplement of the Israeli Securities Law and consents thereto and the Lender
purchases the Securities (to the extent purchased) for his own account and not for distribution or resale purposes.




 


	 	3.2.4.	Regulation S. The Lender understands that the
Securities are being offered and sold to it (to the extent offered or sold) in a transaction not subject to the registration requirements
of United States federal and state securities laws in reliance on Regulation S promulgated under the Securities Act and that the
Company is relying in part upon the truth and accuracy of, and the Lender’s compliance with, the representations, warranties,
agreements, acknowledgments and understandings of the Lender set forth herein in order to determine the compliance of this transaction
with Regulation S and the eligibility of the Lender to receive the Securities. In this regard, the Lender represents and warrants
that the Lender is not a “U.S. Person,” as defined in Rule 902 under the Securities Act, or a person residing in the
United States, and the Lender is not purchasing the Securities (to the extent purchased) on behalf of anyone who is a “U.S.
Person” or a person residing in the United States, and, at the time of each of the origination of contact concerning the
transactions contemplated by this Agreement and the execution and delivery of this Agreement, the Lender was outside of the United
States.




 






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	 	3.2.5.	Experience of Lender. The Lender, either alone
or together with its representatives and advisors, has such knowledge, sophistication and experience in business and financial
matters so as to be capable of evaluating the merits and risks of the transactions contemplated by this Agreement, and has so
evaluated the merits and risks of embedded in this Agreement. The Lender is able to bear the economic risk of the transactions
contemplated hereby and thereby and is able to afford a complete loss of such investment.




 


	 	3.2.6.	General Solicitation.  The Lender is not
purchasing the Securities (to the extent purchased) as a result of any advertisement, article, notice or other communication regarding
the Securities published in any newspaper, magazine or similar media or broadcast over television or radio or presented
at any seminar or any other general solicitation or general advertisement.




 


	 	3.2.7.	Certain Transactions and Confidentiality. Other
than consummating the transactions contemplated hereunder, the Lender has not directly or indirectly, nor has any Person acting
on behalf of or pursuant to any understanding with the Lender, executed any purchases or sales, including short sales, of
the securities of the Company during the period commencing as of the time that the Lender first commenced negotiations (written
or oral) with the Company or any other Person representing the Company setting forth the material terms of the transactions contemplated
hereunder and ending immediately prior to the execution hereof. Other than to such Lender’s representatives, including,
without limitation, his legal and other advisors, employees, agents and Affiliates, the Lender has maintained the confidentiality
of all disclosures made to it in connection with this transaction (including the existence and terms of this Agreement). Notwithstanding
the foregoing, for the avoidance of doubt, nothing contained herein shall constitute a representation or warranty, or preclude
any actions, with respect to locating or borrowing shares in order to effect short sales or similar transactions in the future.




 


	 	3.2.8.	AS-IS; Independent Investigation. The transactions
contemplated under this Agreement (including the potential issuance of the Securities) is made by Lender AS-IS without any representation
made by the Company other than those specifically stated in Section ‎3.1. The Lender has been given the opportunity to ask
questions regarding the Company and its Subsidiary and received answers to such questions.




 


	 	3.2.9.	Financing. The Lender has sufficient available
funds to fulfill his obligations under this Agreement.




 


	 	3.2.10.	Shareholders’ Agreements. As of the date
hereof and until each Closing Date, the Lender, is not a party to any written or oral agreement with any shareholder in the Company
in connection with the purchase or sale of Company’s securities or in connection with voting rights in the Company.




 






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OTHER
AGREEMENTS OF THE PARTIES


 


	4.1.	Securities Laws Disclosure; Publicity. On or
after the date hereof, the Company shall disclose the material terms of the transactions contemplated hereby as required by applicable
law and/or the Nasdaq rules.




 


	4.2.	Amendment of “Subsequent Equity Sales”
Provision included in Existing Warrant. The parties hereby agree to amend Section 3(b) of the Company’s warrants issued to
the Lender under the Securities Purchase Agreement dated as of November 9, 2017 (the “SPA”), in a manner that
such Section 3(b) thereto shall be deleted and replaced with the provisions of Section 3(b) in the Warrant attached hereto, mutatis
mutandis.




 


	4.3.	Termination of “Per Ordinary Share Price Protection”
Provision included in Securities Purchase Agreement. As of Third Closing Date and subject to its consummation, the parties
hereby agree to amend Section 4.4 of the SPA, such that Section ‎2.6.2 of this Agreement shall apply, mutatis mutandis,
to all ADSs the Lender currently holds pursuant to the SPA and Section 4.4 to the SPA be terminated.




 


	4.4.	Taxes. Any taxes, levies, charges and other duties
or other amounts, that are levied or due in connection with the issuance of the Conversion ADSs to the Lender and/or the repayment
of the Loan to the Lender shall be borne by the Lender. In the event that pursuant to any law or regulation, tax is required to
be withheld at source from any payment or repayment made to the Lender, the Company shall withhold said tax at the rate set forth
in the certification issued by applicable tax authority at the rate determined by said law or regulation, unless the Lender has
presented the Company with a valid tax withholding exemption certificate or certificate for reduced tax rate, issued by the applicable
tax authority. The Lender undertakes to deliver to the Company, on or prior to the conversion or repayment of the Loan a valid
withholding tax certificate issued by the applicable tax authority according to which it is explicitly exempt from a withholding
tax on such conversion, or the payment in cash to the Company of tax that should be withheld and be remitted to the applicable
tax authority, as calculated by the Company in its own discretion.




 


MISCELLANEOUS


 


	5.1.	Termination.  Each party to this Agreement
may terminate this Agreement as follows: (a) partially, only with respect the Second Closing, if the Second Closing has not been
consummated on or before March 31, 2020 (the “Second Closing Termination Date”), or (b) partially, only with
respect the Third Closing, if the Third Closing has not been consummated on or before August 1, 2020 (the “Third Closing
Termination Date”), in each case, by delivering a written notice to the other party. Neither party shall have any liability
and/or any claim or demand against the other party (and in the case of the Company, including its directors and officers and any
of its Affiliates) in connection with the termination of this Agreement as aforesaid.




 


The
right to terminate this Agreement under this Section 5.1 shall not be available to any party who shall have breached or failed
to perform any of its representations, warranties, covenants or other agreements contained in this Agreement in any manner that
shall have caused the closing conditions detailed in Section 2.8 not to occur on or before the respective termination date.


 






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	5.2.	Fees and Expenses. On the First Closing Date,
the Company shall pay to Lender, the Lender’s legal expenses in connection with the transactions contemplated by this Agreement
in an amount that shall not exceed thirty thousand United States Dollars ($30,000) plus applicable VAT. Subject to the foregoing,
each party shall pay the fees and expenses of its advisers, counsel, accountants and other experts, if any, and all other expenses
incurred by such party incident to the negotiation, preparation, execution, delivery and performance of this Agreement.




 


	5.3.	Entire Agreement. This Agreement contains the
entire understanding of the parties with respect to the subject matter hereof and thereof and supersede all prior agreements and
understandings, oral or written, with respect to such matters, which the parties acknowledge have been merged into this Agreement.




 


	5.4.	Notices. Any and all notices or other communications
or deliveries required or permitted to be provided hereunder shall be in writing and shall be deemed given and effective on the
earliest of: (a) the date of transmission, if such notice or communication is delivered via facsimile at the facsimile number
or email attachment at the email address as set forth on the signature pages attached hereto at or prior to 5:00 p.m. (Israel
time) on a Business Day, (b) the next Business Day after the date of transmission, if such notice or communication is delivered
via facsimile at the facsimile number or email attachment at the email address as set forth on the signature pages attached hereto
on a day that is not a Business Day or later than 5:00 p.m. (Israel time) on any Business Day, (c) upon actual receipt by the
party to whom such notice is required to be given. The address for such notices and communications shall be as set forth on the
signature pages attached hereto.




 


	5.5.	Amendments; Waivers. No provision of this Agreement
may be waived, modified, supplemented or amended except in a written instrument signed, in the case of an amendment, by the Company
and the Lender. No waiver of any default with respect to any provision, condition or requirement of this Agreement shall be deemed
to be a continuing waiver in the future or a waiver of any subsequent default or a waiver of any other provision, condition or
requirement hereof, nor shall any delay or omission of any party to exercise any right hereunder in any manner impair the exercise
of any such right. Any amendment effected in accordance with this Section 5.5 shall be binding upon each party and its successors
and permitted assignees.




 


	5.6.	Headings. The headings herein are for convenience
only, do not constitute a part of this Agreement and shall not be deemed to limit or affect any of the provisions hereof.




 


	5.7.	Successors and Assigns. This Agreement shall
be binding upon and inure to the benefit of the parties and their successors and permitted assigns. The Company may not assign
this Agreement or any rights or obligations hereunder without the prior written consent of the Lender. So long as the Condition
for Automatic Conversion is not met, the Lender may not assign any of its rights and obligations under this Agreement. Subject
to the foregoing, Lender may assign any or all of his rights under this Agreement to any Person, provided that such transferee
agrees in writing to be bound by the provisions of this Agreement that apply to the Lender.




 






    15 


     


    

 


	5.8.	No Third-Party Beneficiaries. This Agreement
is intended for the benefit of the parties hereto and their respective successors and permitted assigns and is not for the benefit
of, nor may any provision hereof be enforced by, any other Person.




 


	5.9.	Governing Law. All questions concerning the construction,
validity, enforcement and interpretation of this Agreement shall be governed by and construed and enforced in accordance with
the internal laws of the State of Israel, without regard to the principles of conflicts of law thereof. Each party agrees that
all legal Proceedings concerning the interpretations, enforcement and defense of the transactions contemplated by this Agreement
(whether brought against a party hereto or its respective affiliates, directors, officers, shareholders, partners, members, employees
or agents) shall be commenced exclusively in the Tel-Aviv Jaffa court in Israel. Each party hereby irrevocably submits to the
exclusive jurisdiction of the courts in Israel for the adjudication of any dispute hereunder or in connection herewith or with
any transaction contemplated hereby or discussed herein, and hereby irrevocably waives, and agrees not to assert in any Action
or Proceeding, any claim that it is not personally subject to the jurisdiction of any such court, that such Action or Proceeding
is improper or is an inconvenient venue for such Proceeding. Each party hereby irrevocably waives personal service of process
and consents to process being served in any such Action or Proceeding by mailing a copy thereof via registered or certified mail
or overnight delivery (with evidence of delivery) to such party at the address in effect for notices to it under this Agreement
and agrees that such service shall constitute good and sufficient service of process and notice thereof. Nothing contained herein
shall be deemed to limit in any way any right to serve process in any other manner permitted by law. If any party shall commence
an Action or Proceeding to enforce any provisions of this Agreement, then, the prevailing party in such Action or Proceeding shall
be reimbursed by the non-prevailing party for its reasonable attorneys’ fees and other costs and expenses incurred with
the investigation, preparation and prosecution of such Action or Proceeding.




 


	5.10.	Execution. This Agreement may be executed in
two or more counterparts, all of which when taken together shall be considered one and the same agreement and shall become effective
when counterparts have been signed by each party and delivered to each other party, it being understood that the parties need
not sign the same counterpart. In the event that any signature is delivered by facsimile transmission or by e-mail delivery of
a “.pdf” format data file, such signature shall create a valid and binding obligation of the party executing (or on
whose behalf such signature is executed) with the same force and effect as if such facsimile or “.pdf” signature page
were an original thereof.




 


	5.11.	Severability. If any term, provision, covenant
or restriction of this Agreement is held by a court of competent jurisdiction to be invalid, illegal, void or unenforceable, the
remainder of the terms, provisions, covenants and restrictions set forth herein shall remain in full force and effect and shall
in no way be affected, impaired or invalidated, and the parties hereto shall use their commercially reasonable efforts to find
and employ an alternative means to achieve the same or substantially the same result as that contemplated by such term, provision,
covenant or restriction. It is hereby stipulated and declared to be the intention of the parties that they would have executed
the remaining terms, provisions, covenants and restrictions without including any of such that may be hereafter declared invalid,
illegal, void or unenforceable.




 






    16 


     


    

 


	5.12.	Replacement of Securities. If any certificate
or instrument evidencing any Securities is mutilated, lost, stolen or destroyed, the Company shall issue or cause to be issued
in exchange and substitution for and upon cancellation thereof (in the case of mutilation), or in lieu of and substitution therefor,
a new certificate or instrument, but only upon receipt of evidence reasonably satisfactory to the Company of such loss, theft
or destruction. The applicant for a new certificate or instrument under such circumstances shall also pay any required third-party
costs (including customary indemnity) associated with the issuance of such replacement Securities.




 


	5.13.	Remedies. In addition to being entitled to exercise
all rights provided herein or granted by law, including recovery of damages, the Lender and the Company will be entitled to specific
performance under this Agreement. The parties agree that monetary damages may not be adequate compensation for any loss incurred
by reason of any breach of obligations contained in this Agreement and hereby agree to waive and not to assert in any Action for
specific performance of any such obligation the defense that a remedy at law would be adequate.




 


	5.14.	Payment Set Aside. To the extent that the Company
makes a payment or payments to the Lender pursuant to this Agreement or the Lender enforces or exercises its rights thereunder,
and such payment or payments or the proceeds of such enforcement or exercise or any part thereof are subsequently invalidated,
declared to be fraudulent or preferential, set aside, recovered from, disgorged by or are required to be refunded, repaid or otherwise
restored to the Company, a trustee, receiver or any other Person under any law (including, without limitation, any bankruptcy
law, state or federal law, common law or equitable cause of action), then to the extent of any such restoration the obligation
or part thereof originally intended to be satisfied shall be revived and continued in full force and effect as if such payment
had not been made or such enforcement or setoff had not occurred.




 


	5.15.	Saturdays, Sundays, Holidays, etc. If the last
or appointed day for the taking of any action or the expiration of any right required or granted herein shall not be a Business
Day, then such action may be taken or such right may be exercised on the next succeeding Business Day.




 


	5.16.	Construction. The parties agree that each of
them and/or their respective counsel have reviewed and had an opportunity to revise this Agreement and, therefore, the normal
rule of construction to the effect that any ambiguities are to be resolved against the drafting party shall not be employed in
the interpretation of this Agreement or any amendments thereto.




 


(Signature
Pages Follow)


 






    17 


     


    







 


IN
WITNESS WHEREOF, the parties hereto have caused this Convertible Loan Agreement to be duly executed by their respective authorized
signatories as of the date first indicated above.


 


	collplant
BIOTECHNOLOGIES ltd.

         

         

         
	Address
    for Notice:
	By:__________________________________________

        

        Name:
        Yehiel Tal

        

        Title:
        CEO

         

         

         

        By:__________________________________________

        

        Name:
        Eran Rotem

        

        Title:
        Deputy CEO & CFO

         

         

        With
        a copy to (which shall not constitute notice):
	Fax: 

         

        E-Mail:
        yehiel@collplant.com; eran@collplant.com

	 	 
	Gross,
        Kleinhendler, Hodak, Halevy, Greenberg, Shenhav & Co.

         

        One
        Azrieli Center

         

        Tel
        Aviv 6701101, Israel

         

        Attn:
        Adva Bitan, Adv.

         

        Facsimile:
        972-3-607-4464

         

        Email:
        adva@gkh-law.com



 


[REMAINDER
OF PAGE INTENTIONALLY LEFT BLANK


 


SIGNATURE
PAGE FOR LENDER FOLLOWS]


 






    18 


     


    







 


[LENDER
SIGNATURE PAGE TO collplant SECURITIES PURCHASE AGREEMENT] 


 


IN
WITNESS WHEREOF, the undersigned have caused this Convertible Loan Agreement to be duly executed by their respective authorized
signatories as of the date first indicated above.


 


Name
of Lender: ______________________________________________________________________


 


Email
Address of Lender: _______________________________________________________________


 


Facsimile
Number of Lender: _____________________________________________________________


 


Address
for Notice to Lender: ____________________________________________________________


 


 


 


With
a copy to (which shall not constitute notice):


 


 


 


Meitar
Liquornik Geva Leshem Tal


 


16
Abba Hillel Silver Road


 


Ramat
Gan 5250608, Israel


 


Attn:
Mike Rimon, Adv.


 


Facsimile:
972-3-610-3687


 


Email:
mrimon@meitar.com


 


 


 


Address
for Delivery of Securities to Lender (if not same as address for notice): _____________


 


 


19