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Thiram																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 137–26–8
**NIOSH REL:** 5 mg/m3 TWA
**Current OSHA PEL:** 5 mg/m3 TWA
**1989 OSHA PEL:** Same as current PEL
**1993-1994 ACGIH TLV:** 1 mg/m3 TWA
**Description of substance:** Colorless to yellow, crystalline solid with a characteristic odor.
**LEL**: . Unknown
**Original (SCP) IDLH:** 1,500 mg/m3
**Basis for original (SCP) IDLH:** The chosen IDLH has been estimated from the rabbit oral LD50 of 210 mg/kg [Sakuramoto 1977 cited by NIOSH 1976]. Rats survived a 4-hour exposure to concentrations above 500 mg/m3 [Smyth 1937-1955 cited by ACGIH 1971].
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA:**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50**
    **LCLo**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived value**Rat
    Marhold 1986
    500 mg/m3
    -----
    4 hr
    1,000 mg/m3 (2.0)
    100 mg/m3**Lethal dose data:**
 
 **Species**
    **Reference**
    **Route**
    **LD50** **(mg/kg)**
    **LDLo** **(mg/kg)**
    **Adjusted LD**
    **Derived value**Mouse
    Arkhangel'skaya &Roshchina 1964
    oral
    1,350
    -----
    9,450 mg/m3
    945 mg/m3Rabbit
    Sakuramoto 1977
    oral
    210
    -----
    1,470 mg/m3
    147 mg/m3Rat
    Weiss and Orzel 1967
    oral
    560
    -----
    3,920 mg/m3
    392 mg/m3**Other animal data:** Rats have survived a 4-hr exposure to concentrations exceeding 500 mg/m3 [Smyth 1937-1955].
 **Human data:** None relevant for use in determining the revised IDLH.
 
 **Revised IDLH:** 100 mg/m3**Basis for revised IDLH:** The revised IDLH for thiram is 100 mg/m3 based on acute inhalation toxicity data in animals [Marhold 1986]. This may be a conservative value due to the lack of relevant acute inhalation toxicity data for workers.**REFERENCES:**
1. ACGIH [1971]. Thiram (tetramethyl thiuram disulfide). In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 257.
2. ACGIH [1991]. Thiram. In: Documentation of the threshold limit values and biological exposure indices. 6th ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 1545-1549.]
3. Arkhangel’skaya LN, Roshchina TA [1964]. Toxicological characterization of furfuramide, a new vulcanization accelerator. Gig Sanit *29*(7):37-42 (translated).
4. Marhold J [1986]. Prehled Prumyslove Toxikologie, Organicke Latky. Prague, Czechoslovakia: Avicenum, p. 1027 (in Czechoslovakian).
5. NIOSH [1976]. JO14000. Disulfide, bis(dimethylthiocarbamoyl)-. In: Registry of toxic effects of chemical substances, 1976 ed. Cincinnati, OH: U.S. Department of Health, Education, and Welfare, Public Health Service, Center for Disease Control, National Institute for Occupational Safety and Health, DHEW (NIOSH) Publication No. 76-191, p. 462.
6. Sakuramoto Y [1977]. Potential health problems of latex products. Kabunshi Kankokai *26*:361 (in Japanese).
7. Smyth HF Jr [1937-1955]. Unpublished work by Chemical Hygiene Fellowship, Mellon Institute, Pittsburgh, PA. [From ACGIH [1991]. Thiram. In: Documentation of the threshold limit values and biological exposure indices. 6th ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 1545-1549.]
8. Weiss LR, Orzel RA [1967]. Some comparative toxicologic and pharmacologic effects of dimethyl sulfoxide as a pesticide solvent. Toxicol Appl Pharmacol *11*:546-557.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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