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Heptachlor																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 76–44–8
**NIOSH REL:** 0.5 mg/m3 TWA [skin]; NIOSH considers heptachlor to be a potential occupational carcinogen as defined by the OSHA carcinogen policy [29 CFR 1990].
**Current OSHA PEL:** 0.5 mg/m3 TWA [skin]
**1989 OSHA PEL:** Same as current PEL
**1993-1994 ACGIH TLV:** 0.5 mg/m3 TWA [skin]
**Description of Substance:** White to light-tan crystals with a camphor-like odor.
**LEL:**. . Noncombustible Solid
**Original (SCP) IDLH:** 700 mg/m3
**Basis for original (SCP) IDLH:** No data on acute inhalation toxicity are available on which to base the IDLH for heptachlor. The chosen IDLH, therefore, has been estimated from the male rat oral LD50 of 100 mg/kg [Gaines 1960 cited by ACGIH 1971].
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50** **(ppm)**
    **LCLo** **(ppm)**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived** **value**Cat Mammal
    Izmerov et al. 1982 Osetrov 1958
    ----- -----
    150 mg/m3200 mg/m3
    4 hr 4 hr
    300 mg/m3 (2.0) 400 mg/m3 (2.0)
    30 mg/m340 mg/m3
 **Lethal dose data:**
 
 **Species**
    **Reference**
    **Route**
    **LD50** **(mg/kg)**
    **LDLo** **(mg/kg)**
    **Adjusted LD**
    **Derived value**G. pig RatRatMouseCatHamster
    AAPCO 1966 Edson 1960Gaines 1960Kenaga and Morgan 1978Osetrov 1958Truhaut et al. 1974
    oral oraloraloraloraloral
    116 4010068-----100
    ----- ---------------50-----
    812 mg/m3280 mg/m3700 mg/m3476 mg/m3350 mg/m3700 mg/m3
    81 mg/m328 mg/m370 mg/m348 mg/m335 mg/m370 mg/m3
 **Human data:** None relevant for use in determining the revised IDLH.
 
 **Revised IDLH:** 35 mg/m3**Basis for revised IDLH:** The revised IDLH for heptachlor is 35 mg/m3 based on acute inhalation toxicity data in animals [Izmerov et al. 1982; Osetrov 1958]. [Note: NIOSH recommends as part of its carcinogen policy that the "most protective" respirators be worn for heptachlor at concentrations above 0.5 mg/m3.]
**REFERENCES:**
1. AAPCO [1966]. Pesticide chemicals official compendium. Topeka, KS: Association of the American Pesticide Control Officials, Inc. p. 576.
2. ACGIH [1971]. Heptachlor. In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 123-124.
3. Edson EF [1960]. Applied toxicology of pesticides. Pharmaceut J *185*:361-367.
4. Gaines TB [1960]. The acute toxicity of pesticides to rats. Toxicol Appl Pharmacol *2*:88-99.
5. Izmerov NF, Sanotsky IV, Sidorov KK [1982]. Toxicometric parameters of industrial toxic chemicals under single exposure. Moscow, Russia: Centre of International Projects, GKNT, p. 71.
6. Kenaga EE, Morgan RW [1978]. Commercial and experimental organic insecticides. Entomological Society of America Special Publication *78-1*:12.
7. Osetrov VE [1958]. Experimental data on toxicology of the insecticide heptachlor. Gig Tr Prof Zabol *2*(5):15 (in Russian).
8. Truhaut R, Gak JC, Graillot C [1974]. Recherches sur les modalités et les mécanismes d’action toxique des insecticides organochlorés. I. Étude comparative des effets de toxicité aiguë chez le hamster et chez le rat. J Eur Toxicol *7*(3):159-166 (in French).

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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