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sec-Butyl alcohol																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 78–92–2
**NIOSH REL:** 100 ppm (305 mg/m3) TWA, 150 ppm (455 mg/m3) STEL
**Current OSHA PEL:** 150 ppm (450 mg/m3) TWA
**1989 OSHA PEL:** 100 ppm (305 mg/m3) TWA
**1993-1994 ACGIH TLV:** 100 ppm (303 mg/m3) TWA
**Description of Substance:** Colorless liquid with a strong, pleasant odor.
**LEL(@212 F):** 1.7% (10% LEL(@212 F), 1,700 ppm)
**Original (SCP) IDLH:** 10,000 ppm
**Basis for original (SCP) IDLH:** The chosen IDLH is based on the statements by Patty [1963] that 10,670 ppm for 225 minutes and 16,000 ppm for 160 minutes were fatal for mice [Weese 1928]. According to Patty [1963], at 20,000 ppm it took 12 to 20 minutes to produce prostration in mice and 40 minutes to produce narcosis; no deaths occurred [Starrek 1938]. The chosen IDLH is probably conservative.
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50** **(ppm)**
    **LCLo** **(ppm)**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived** **Value**Rat MouseMouse
    Shell 1985 Weese 1928Weese 1928
    ----- ----------
    16,000 10,67016,000
    4 hr 3.75 hr2.67 hr
    32,000 ppm (2.0) 20,913 ppm (1.96)28,000 ppm (1.75)
    3,200 ppm 2,091 ppm2,800 ppm
 **Other animal data:** The limited acute toxicity data indicate that sec-butyl alcohol is less toxic than n-butyl alcohol [ACGIH 1991].
 **Human data:** None relevant for use in determining the revised IDLH.
 
 **Revised IDLH:** 2,000 ppm **Basis for revised IDLH:** The revised IDLH for sec-butyl alcohol is 2,000 ppm based on acute inhalation toxicity data in animals [Weese 1928]. This value also approximates 10% of the lower explosive limit (LEL) of 1.7% (which was determined at 212 F) and the revised IDLH for n-butyl alcohol. This may be a conservative value due to the lack of relevant acute toxicity data for workers.
**REFERENCES:**
1. ACGIH [1991]. sec-Butyl alcohol. In: Documentation of the threshold limit values and biological exposure indices. 6th ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 172-173.
2. Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 1447.
3. Shell [1985]. Material safety data sheet S280-4: secondary butyl alcohol. Houston, TX: Shell Chemical Company, pp. 1-4.
4. Starrek E [1938]. The effect of some alcohols, glycols, and esters. Doctoral dissertation (translated). Wurzburg, Germany: Julius Maximillian University.
5. Weese H [1928]. Comparative studies of the effect and toxicity of the vapors of lower aliphatic alcohols. Arch Exp Pathol Pharmakol *135*:118-130 (translated).

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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