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Chlorinated diphenyl oxide																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 31242–93–0
**NIOSH REL:** 0.5 mg/m3 TWA
**Current OSHA PEL:** 0.5 mg/m3 TWA
**1989 OSHA PEL:** Same as current PEL
**1993-1994 ACGIH TLV:** 0.5 mg/m3 TWA
**Description of Substance:** Light-yellow, very viscous, waxy liquid.
**LEL:** . . Unknown
**Original (SCP) IDLH*:** Unknown [*Note: “Effective” IDLH = 5 mg/m3 — see discussion below.]
**Basis for original (SCP) IDLH:** No quantitative data are available concerning the toxic effects produced by the inhalation of chlorinated diphenyl oxide. Therefore, for this draft technical standard, using an analogy with the chloronaphthalenes, the respirators have been selected on the basis of the assigned protection factor afforded by each device up to 10 × the OSHA PEL of 0.5 mg/m3 (i.e., 5 mg/m3); only the “most protective” respirators are permitted for use in concentrations exceeding 5 mg/m3.
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA**
**Lethal dose data:**

**Species**
    **Reference**
    **Route**
    **LD50** **(mg/kg)**
    **LDLo** **(mg/kg)**
    **Adjusted LD**
    **Derived** **value**C12H9ClO G. pig
    Clayton and Clayton 1981
    oral
    -----
    600
    4,200 mg/m3
    420 mg/m3C12H8Cl2O G. pig
    Clayton and Clayton 1981
    oral
    -----
    1,000
    7,000 mg/m3
    700 mg/m3C12H7Cl3O G. pig
    Clayton and Clayton 1981
    oral
    -----
    1,200
    8,400 mg/ m3
    840 mg/m3C12H6Cl4O G. pig
    Clayton and Clayton 1981
    oral
    -----
    50
    350 mg/m3
    35 mg/m3C12H5Cl5O G. pigRabbit
    Clayton and Clayton 1981 Hofmann 1957
    oral oral
    ----- -----
    100 0.3
    700 mg/m32.1 mg/m3
    70 mg/m30.2 mg/m3C12H4Cl6O G. pig
    Clayton and Clayton 1981
    oral
    -----
    50
    350 mg/m3
    35 mg/m3C12H3Cl7O Rat
    NAS 1953
    oral
    -----
    500
    3,500 mg/m3
    350 mg/m3C12H2Cl8O Rat
    NAS 1953
    oral
    -----
    500
    3,500 mg/m3
    350 mg/m3C12HCl9O Rat
    NAS 1953
    oral
    -----
    500
    3,500 mg/m3
    350 mg/m3
 **Human data:** None relevant for use in determining the revised IDLH.
 
 **Revised IDLH:** 5 mg/m3**Basis for revised IDLH:** No inhalation toxicity data are available on which to base an IDLH for chlorinated diphenyl oxide. Based on acute oral toxicity data in animals [Clayton and Clayton 1981], a value of about 35 mg/m3 would have been appropriate for chlorinated diphenyl oxide. However, the revised IDLH for chlorinated diphenyl oxide is 5 mg/m3 based on being 10 times the NIOSH REL and OSHA PEL of 0.5 mg/m3 (10 is an assigned protection factor for respirators and was used during the Standards Completion Program for deciding when the "most protective" respirators should be used for chlorinated diphenyl oxide).
**REFERENCES:**
1. Clayton GD, Clayton FE, eds. [1981]. Patty’s industrial hygiene and toxicology. 3rd rev. ed. Vol. 2A. Toxicology. New York, NY: John Wiley & Sons, Inc., p. 2550.
2. Hofmann HT [1957]. Neuere erfahrungen mit hochtoxischen chlorkohlenwasserstoffen. Arch Exp Pathol Pharmakol *243*:228 (in German).
3. NAS [1953]. Relationship between chemical structure and toxic action on rats. National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review *5*:16.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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