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Ozone																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)

**CAS number:** 10028–15–6
**NIOSH REL:** 0.1 ppm (0.2 mg/m3) CEILING
**Current OSHA PEL:** 0.1 ppm (0.2 mg/m3) TWA
**1989 OSHA PEL:** 0.1 ppm (0.2 mg/m3) TWA, 0.3 ppm (0.6 mg/m3) STEL
**1993-1994 ACGIH TLV:** 0.1 ppm (0.2 mg/m3) CEILING
**Description of substance:** Colorless to blue gas with a very pungent odor.
**LEL:** . . Nonflammable Gas
**Original (SCP) IDLH:** 10 ppm
**Basis for original (SCP) IDLH:** The chosen IDLH is based on the statement by AIHA [1966] that pulmonary edema developed in welders who had a severe acute exposure to an estimated 9 ppm ozone plus other air pollutants [Kleinfeld et al. 1957]. Patty [1963] reported that 15 to 20 ppm is lethal to small animals within 2 hours [Witheridge and Yaglou 1937]. AIHA [1966] also reported that on the basis of animal data, exposure at 50 ppm for 60 minutes will probably be fatal to humans [King 1963].
**Existing short-term exposure guidelines:** National Research Council [NRC 1984] Emergency Exposure Guidance Levels (EEGLs):
1-hour EEGL: 1 ppm
24-hour EEGL: 0.1 ppm
**ACUTE TOXICITY DATA:**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50** **(ppm)**
    **LCLo** **(ppm)**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived value**Mouse HumanRabbitMouseRatG. pigRat
    Clamann & Bancroft 1957 Deichmann & Gerarde 1969Mittler et al. 1956Mittler et al. 1956Mittler et al. 1956Mittler et al. 1957Stokinger 1957
    ----- ------------------------------
    12.6 50362121.824.84.8
    3 hr 30 min3 hr3 hr3 hr3 hr4 hr
    23 ppm (1.8) 50 ppm (1.0)65 ppm (1.8)38 ppm (1.8)39 ppm (1.8)45 ppm (1.8)10 ppm (2.0)
    2.3 ppm 5.0 ppm6.5 ppm3.8 ppm3.9 ppm4.5 ppm1.0 ppm**Other animal data:** It has been reported that 15 to 20 ppm is lethal to small animals within 2 hours [Witheridge and Yaglou 1937].
 **Human data:** Pulmonary edema developed in welders who had a severe acute exposure to an estimated 9 ppm ozone plus other air pollutants [Kleinfeld et al. 1957]. It has been reported that on the basis of animal data, exposure at 50 ppm for 60 minutes will probably be fatal to humans [King 1963].
 
 **Revised IDLH:** 5 ppm **Basis for revised IDLH:** The revised IDLH for ozone is 5 ppm based on acute inhalation toxicity data in humans [Deichmann and Gerarde 1969; Kleinfeld et al. 1957].**REFERENCES:**
1. AIHA [1966]. Ozone. In: Hygienic guide series. Am Ind Hyg Assoc J *27*:196-198.
2. Clamann HG, Bancroft RW [1957]. Physiological effects of ozone. Fed Proc *16*:22 [Abstract].
3. Deichmann WB, Gerarde HW [1969]. Ozone. In: Toxicity of drugs and chemicals. New York, NY: Academic Press, Inc., pp. 446-448.
4. King ME [1963]. Toxicity of ozone. V. Factors affecting acute toxicity. Ind Med Surg *32*:93-94.
5. Kleinfeld M, Giel C, Tabershaw IR [1957]. Health hazards associated with inert-gas-shielded metal arc welding. AMA Arch Ind Health *15*(1):27-31.
6. Mittler S, Hedrick D, King M, Gaynor A [1956]. Toxicity of ozone. I. Acute toxicity. Ind Med Surg *25*:301-306.
7. Mittler S, Hedrick D, Phillips L [1957]. Toxicity of ozone. II. Effect of oxygen and carbon dioxide upon acute toxicity. Ind Med Surg *26*:63-66.
8. NRC [1984]. Emergency and continuous exposure limits for selected airborne contaminants. Vol. 1. Washington, DC: National Academy Press, Committee on Toxicology, Board on Toxicology and Environmental Health Hazards, Commission on Life Sciences, National Research Council, pp. 99-106.
9. Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 917.
10. Stokinger HE [1957]. Evaluation of the hazards of ozone and oxides of nitrogen. Arch Ind Health *15*:181-190.
11. Witheridge WN, Yaglou CP [1937]. Ozone in ventilation: its possibilities and limitations. Trans Am Soc Heat Vent Eng *45*(1132):509-522.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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