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1,2,3-Trichloropropane																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 96–18–4
**NIOSH REL:** 10 ppm (60 mg/m3) TWA [skin]; NIOSH considers 1,2,3-trichloropropane to be a potential occupational carcinogen as defined by the OSHA carcinogen policy [29 CFR 1990].
**Current OSHA PEL:** 50 ppm (300 mg/m3) TWA
**1989 OSHA PEL:** 10 ppm (60 mg/m3) TWA
**1993-1994 ACGIH TLV:** 10 ppm (60 mg/m3) TWA [skin]
**Description of substance:** Colorless liquid with a chloroform-like odor.
**LEL**(@248°F) : 3.2% (10% LEL(@248°F), 3,200 ppm)
**Original (SCP) IDLH:** 1,000 ppm
**Basis for original (SCP) IDLH:** UCC [1973] reported that 5 of 6 rats died following a 1-hour exposure to 5,600 ppm. Because several mice died following only a 20-minute exposure to 5,000 ppm [McOmie and Barnes 1949 as cited by ACGIH 1971], 5,000 ppm has not been chosen as the IDLH. The chosen IDLH is based on the rat 4-hour LCLO of 1,000 ppm [Smyth et al. 1962 cited by NIOSH 1976].
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA:**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50** **(ppm)**
    **LCLo** **(ppm)**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived value**Mouse
    Izmerov et al. 1982
    555
    -----
    2 hr
    888 ppm (1.6)
    89 ppmMouse
    McOmie & Barnes 1949
    -----
    5,000
    20 min
    4,350 ppm (0.87)
    435 ppmRat
    McOmie & Barnes 1949
    LC100: 700
    -----
    4 hr
    1,400 ppm (2.0)
    140 ppmMouse
    McOmie & Barnes 1949
    LC100: 700
    -----
    4 hr
    1,400 ppm (2.0)
    140 ppmMouse
    McOmie &Barnes 1949
    LC100: 340
    -----
    4 hr
    680 ppm (2.0)
    68 ppmRat
    Smyth et al. 1962
    LC83: 1,000
    -----
    4 hr
    2,000 ppm (2.0)
    200 ppmRat
    UCC 1973
    LC83: 5,600
    -----
    1 hr
    7,000 ppm (1.25)
    700 ppm**Human data:** It has been reported that objectionable ocular and mucosal irritation were experienced after 15 minutes of exposure to 100 ppm [Silverman et al. 1946].
 
 **Revised IDLH:** 100 ppm **Basis for revised IDLH:** The revised IDLH for 1,2,3-trichloropropane is 100 ppm based on acute inhalation toxicity data in humans [Silverman et al. 1946]. This may be a conservative value due to the lack of relevant acute toxicity data for workers exposed to concentrations above 100 ppm. [Note: NIOSH recommends as part of its carcinogen policy that the "most protective" respirators be worn for 1,2,3-trichloropropane at concentrations above 10 ppm.]**REFERENCES:**
1. ACGIH [1971]. 1,2,3-Trichloropropane. In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 266-267.
2. Izmerov NF, Sanotsky IV, Sidorov KK [1982]. Toxicometric parameters of industrial toxic chemicals under single exposure. Moscow, Russia: Centre of International Projects, GKNT, p. 114.
3. McOmie WA, Barnes TR [1949]. Acute and subchronic toxicity of 1,2,3-trichloropropane in mice and rabbits. Fed Proc 8:319.
4. NIOSH [1976]. TZ92750. Propane, 1,2,3-trichloro-. In: Registry of toxic effects of chemical substances, 1976 ed. Cincinnati, OH: U.S. Department of Health, Education, and Welfare, Public Health Service, Center for Disease Control, National Institute for Occupational Safety and Health, DHEW (NIOSH) Publication No. 76-191, p. 969.
5. Silverman L, Schulte HF, First MW [1946]. Further studies on sensory response to certain industrial solvent vapors. J Ind Hyg Toxicol 28:262-266.
6. Smyth HF Jr, Carpenter CP, Weil CS, Pozzani UC, Striegel JA [1962]. Range finding toxicity data: list VI. Am Ind Hyg Assoc J 23:95-107.
7. UCC [1973]. Toxicology studies: 1,2,3-trichloropropane. New York, NY: Union Carbide Corporation.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
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