Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link


Centers for Disease Control and Prevention. CDC twenty four seven. Saving Lives, Protecting People
					Search
		×
			NIOSH
			NIOSH
				All CDC
				Submit
			For a full list of topics:A-Z Index
			Advanced Search
		Advanced Search


The National Institute for Occupational Safety and Health (NIOSH)


Facebook
        Twitter
        LinkedIn
        Syndicate





Dinitro-o-cresol																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number;** 534-52-1
**NIOSH REL:** 0.2 mg/m3 TWA [skin]
**Current OSHA PEL:** 0.2 mg/m3 TWA [skin]
**1989 OSHA PEL:** Same as current PEL
**1993-1994 ACGIH TLV:** 0.2 mg/m3 TWA [skin]
**Description of Substance:** Yellow, odorless solid.
**LEL:**. . Unknown
**Original (SCP) IDLH:** 5 mg/m3
**Basis for original (SCP) IDLH:** The chosen IDLH is based on the statement by Hunter [1969] that 4.7 mg/m3 per day caused the following symptoms in a factory worker: fever, weight loss, a 400% rise in the basal rate of metabolism, rapid pulse, rapid respiration, profuse sweating, shortness of breath, and cough [McDonald 1943]. It is obvious that the chosen IDLH has been set conservatively, but no other quantitative data are available on which to base an IDLH.
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50**
    **LCLo**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived** **value**Cat
    Burkatskaya 1965
    LC33: 40 mg/m3
    -----
    4 hr
    80 mg/m3 (2.0)
    8.0 mg/m3
 **Lethal dose data:**
 
 **Species**
    **Reference**
    **Route**
    **LD50** **(mg/kg)**
    **LDLo** **(mg/kg)**
    **Adjusted LD**
    **Derived value**Rat CatMouseRabbitG. pigRat
    Colliot 1972 DeCeaurriz et al. 1981MacEwen and Vernot 1972Popov and Vrochinsky 1976Popov and Vrochinsky 1976Spencer et al. 1948
    oral oraloraloraloraloral
    7 502124.624.631
    ----- -------------------------
    49 mg/m3350 mg/m3147 mg/m3172 mg/m3172 mg/m3217 mg/m3
    4.9 mg/m335 mg/m315 mg/m317 mg/m317 mg/m322 mg/m3
 **Human data:** An exposure of 4.7 mg/m3 per day resulted in fever, a basal metabolic rate of 400, rapid pulse and respiration, profuse sweating, shortness of breath, and cough [Fairhall 1957]. A single oral dose 75 mg produced no toxic effects in five volunteers [Harvey et al. 1951]. [Note: An oral dose of 75 mg is equivalent to a worker being exposed to 50 mg/m3 for 30 minutes, assuming a breathing rate of 50 liters per minute and 100% absorption.]
 
 **Revised IDLH:** 5 mg/m3 [Unchanged] **Basis for revised IDLH:** Based on acute toxicity data in humans [Fairhall 1957; Harvey et al. 1951] and animals [Colliot 1972], the original IDLH for dinitro-o-cresol (5 mg/m3) is not being revised at this time.
**REFERENCES:**
1. Burkatskaya EN [1965]. Maximum permissible concentration of dinitro-o-cresol in air. Gig Tr Prof Zabol *30*:34-37 (in Russian).
2. Colliot F [1972]. Intérêt présenté par l’acétate de dinoterbe pour le traitement d’hiver des arbres fruitiers et de la vigne. Defensi des Vegetaux *26*:69-84 (in French).
3. DeCeaurriz JC, Micillino JC, Bonnet P, Guenier JP [1981]. Sensory irritation caused by various industrial airborne chemicals. Toxicol Lett *9*(4):137-143.
4. Fairhall LT [1957]. Industrial toxicology. 2nd ed. Baltimore, MD: Williams & Wilkins Company, p. 230.
5. Harvey DG, Bidstrup PL, Bonnell JAL [1951]. Poisoning by dinitro-ortho-cresol. Some observations on the effects of dinitro-ortho-cresol administered by mouth to human volunteers. Br J Med *2*:13-15.
6. Hunter D [1969]. Dinitro-ortho-cresol. In: The diseases of occupations. 4th ed. Boston, MA: Little, Brown and Company, pp. 559-567.
7. MacEwen JD, Vernot EH [1972]. Toxic Hazards Research Unit annual report: 1972. Wright-Patterson Air Force Base, OH: Air Force Systems Command, Aerospace Medical Division, Aerospace Medical Research Laboratory Report, AMRL-TR-72-62.
8. McDonald JM [1943]. Industrial hygiene in wartime Baltimore. Baltimore Health News *20*(9):169-170.
9. Popov TA, Vrochinsky KK [1976]. Materials on substantiation of the threshold of DNOC in water bodies. Gig Sanit *41*(6):12-15 (in Russian).
10. Spencer HC, Rowe VK, Adams EM, Irish DD [1948]. Toxicological studies on laboratory animals of certain alkyldinitrophenols used in agriculture. J Ind Hyg Toxicol *30*:10-28.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
Pinterest
Twitter
YouTube
 NIOSH Homepage NIOSH A-Z
Workplace Safety & Health Topics
Publications and Products
Programs
Contact NIOSH


About CDC
					Contact Us
					800-232-4636
 Facebook Twitter Instagram LinkedIn Youtube Pinterest Snapchat
 CONTACT CDC
				Contact Us
							Call 800-232-4636
							Email Us
			ABOUT CDC
				About CDC
							Jobs
							Funding
			POLICIES
				Accessibility
							External Links
							Privacy
							Policies
							No Fear Act
							FOIA
							OIG
							Nondiscrimination
							Vulnerability Disclosure Policy
			CONNECT WITH US
				Facebook
								Twitter
								Instagram
								LinkedIn
							Youtube
								Pinterest
								Snapchat
								Email
			LANGUAGES
				Español
							繁體中文
							Tiếng Việt
							한국어
							Tagalog
							Русский
							العربية
							Kreyòl Ayisyen
							Français
							Polski
							Português
							Italiano
							Deutsch
							日本語
							فارسی
							English


U.S. Department of Health & Human Services
			Accessibility
			External Links
			Privacy
			Policies
			No Fear Act
			FOIA
			Nondiscrimination
			OIG
			Vulnerability Disclosure Policy
			USA.gov


Exit Notification/Disclaimer Policy Close
 Links with this icon  indicate that you are leaving the CDC website. The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website.
					Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website.
					You will be subject to the destination website's privacy policy when you follow the link.
					CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website. Website Disclaimers
 Cancel Continue