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Chlorobenzene																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 108–90–7
**NIOSH REL:** The 1989 OSHA PEL may not be protective to workers.
**Current OSHA PEL:** 75 ppm (350 mg/m3) TWA
**1989 OSHA PEL:** Same as current PEL
**1993-1994 ACGIH TLV:** 10 ppm (46 mg/m3) TWA
**Description of Substance:** Colorless liquid with an almond-like odor.
**LEL:** . . 1.3% (10% LEL, 1,300 ppm)
**Original (SCP) IDLH:** 2,400 ppm
**Basis for original (SCP) IDLH:** AIHA [1964] reported that 8,000 ppm was fatal to cats in 30 minutes [Patty 1963; Flury and Zernik 1931]. Patty [1963] reported that the exposure of cats for 1 hour to 2,400 to 2,900 ppm causes unsteadiness, tremor, and twitching [Flury and Zernik 1931]. Based on the data cited above, an IDLH of 2,400 ppm is chosen for this draft technical standard.
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50** **(ppm)**
    **LCLo** **(ppm)**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived** **value**Rat RatCat
    Eastman 1978 Eastman 1978Flury and Zernik 1931
    LC67: 22,000 LC67: 9,000
    ----- -----8,000
    2.3 hr 3 hr3 hr
    36,520 ppm (1.66) 16,200 ppm (1.8)8,000 ppm (1.0)
    3,652 ppm 1,620 ppm800 ppm
 **Lethal dose data:**
 
 **Species**
    **Reference**
    **Route**
    **LD50** **(mg/kg)**
    **LDLo** **(mg/kg)**
    **Adjusted LD**
    **Derived value**Rat RabbitMouseG. pig
    Clayton and Clayton 1981 Clayton and Clayton 1981Izmerov et al. 1982Izmerov et al. 1982
    oral oraloraloral
    2,290 2,2502,3002,250
    ----- ---------------
    3,425 ppm 3,365 ppm3,440 ppm3,365 ppm
    343 ppm 337 ppm344 ppm337 ppm
 **Other animal data:** RD50 (mouse), 1,054 ppm [DeCeaurriz et al. 1981].
 **Human data:** None relevant for use in determining the revised IDLH.
 
 **Revised IDLH:** 1,000 ppm **Basis for revised IDLH:** The revised IDLH for chlorobenzene is 1,000 ppm based on acute inhalation toxicity data in animals [DeCeaurriz et al. 1981; Flury and Zernik 1931].
**REFERENCES:**
1. AIHA [1964]. Chlorobenzene. In: Hygienic guide series. Am Ind Hyg Assoc J *25*:97-99.
2. Clayton GD, Clayton FE, eds. [1981]. Patty’s industrial hygiene and toxicology. Vol. 2B. Toxicology. 3rd rev. ed. New York, NY: John Wiley & Sons, Inc., p. 3603.
3. DeCeaurriz JC, Micillino JC, Bonnet P, Guenier JP [1981]. Sensory irritation caused by various industrial airborne chemicals. Toxicol Lett *9*:137-143.
4. Eastman Kodak Company [1978]. Toxicity and health hazard summary. Rochester, NY. [From ACGIH [1971]. Chlorobenzene. In: Documentation of threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 48-49.]
5. Flury F, Zernik F [1931]. Schädliche gase dämpfe, nebel, rauch- und staubarten. Berlin, Germany: Verlag von Julius Springer, p. 337 (in German).
6. Izmerov NF, Sanotsky IV, Sidorov KK [1982]. Toxicometric parameters of industrial toxic chemicals under single exposure. Moscow, Russia: Centre of International Projects, GKNT, p. 34.
7. Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 1334.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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