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Hexachloroethane																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 67–72–1
**NIOSH REL:** 1 ppm (10 mg/m3) TWA [skin]; NIOSH considers hexachloroethane to be a potential occupational carcinogen as defined by the OSHA carcinogen policy [29 CFR 1990].
**Current OSHA PEL:** 1 ppm (10 mg/m3) TWA [skin]
**1989 OSHA PEL:** Same as current PEL
**1993-1994 ACGIH TLV:** 1 ppm (9.7 mg/m3) TWA [skin], A2
**Description of Substance:** Colorless crystals with a camphor-like odor.
**LEL:**. . Noncombustible Solid
**Original (SCP) IDLH:** 300 ppm
**Basis for original (SCP) IDLH:** Based on the toxicological data relating to potential liver injury [Gleason et al. 1969; Elkins 1959], 300 ppm, the saturated vapor pressure at 20 C [Kirk-Othmer 1964] has been chosen as the IDLH.
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA**
**Lethal dose data:**

**Species**
    **Reference**
    **Route**
    **LD50** **(mg/kg)**
    **LDLo** **(mg/kg)**
    **Adjusted LD**
    **Derived value**Rat G. pig
    Weeks et al. 1979 Weeks et al. 1979
    oral oral
    4,460 4,970
    ----- -----
    3,173 ppm 3,536 ppm
    317 ppm 354 ppm
 **Human data:** None relevant for use in determining the revised IDLH.
 
 **Revised IDLH:** 300 ppm [Unchanged] **Basis for revised IDLH:** No inhalation toxicity data are available on which to base an IDLH for hexachloroethane. Therefore, based on acute oral toxicity data in animals [Weeks et al. 1979], the original IDLH for hexachloroethane (300 ppm) is not being revised at this time. [Note: NIOSH recommends as part of its carcinogen policy that the "most protective" respirators be worn for hexachloroethane at concentrations above 1 ppm.]
**REFERENCES:**
1. Elkins HB [1959]. Hexachloroethane, C2Cl6. In: The chemistry of industrial toxicology. 2nd ed. New York, NY: John B. Wiley & Sons, Inc., pp. 142-143.
2. Gleason MN, Gosselin RE, Hodge HC, Smith RP [1969]. Clinical toxicology of commercial products. 3rd ed. Baltimore, MD: Williams & Wilkins Company, pp. II-76, III-65 to III-67.
3. Kirk-Othmer [1964]. Encyclopedia of chemical technology. 2nd ed. New York, NY: John Wiley & Sons, Inc. *5*:166.
4. Weeks MH, Angerhofer KA, Bishop R, et al. [1979]. The toxicity of hexachloroethane in laboratory animals. Am Ind Hyg Assoc J *40*:187-199.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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