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Tin (inorganic compounds, as Sn)																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 7440–31–5 (Metal)
**NIOSH REL:** 2 mg/m3 TWA
**Current OSHA PEL:** 2 mg/m3 TWA
**1989 OSHA PEL:** Same as current PEL
**1993-1994 ACGIH TLV:** 2 mg/m3 TWA
**Description of substance:** Varies
**Original (SCP) IDLH:** 400 mg Sn/m3
**Basis for original (SCP) IDLH:** The chosen IDLH is based on the toxicity of stannous chloride. ACGIH [1971] indicated that inorganic tin salts are of high acute toxicity. ILO [1972] reported evidence exists that stannous chloride can cause paralysis in animals. No data on acute inhalation toxicity are available on which to base the IDLH. The chosen IDLH is based on the dog intravenous LDLO of 20 mg/kg for stannous chloride [Patenko 1886 as cited by Flury and Zernik 1935] cited by NIOSH. The chosen IDLH is likely to be conservative.
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA:**
**Lethal dose data:**

**Species**
    **Reference**
    **Route**
    **LD50** **(mg/kg)**
    **LDLo** **(mg/kg)**
    **Adjusted LD**
    **Derived value**SnSO4 Rat
    Gig Sanit 1986
    oral
    2,207
    -----
    8,497 mg Sn/m3
    850 mg Sn/m3SnSO4 Mouse
    Gig Sanit 1986
    oral
    2,152
    -----
    8,285 mg Sn/m3
    829 mg Sn/m3SnCl2 Rat
    Calvery 1942
    oral
    700
    -----
    3,087 mg Sn/m3
    309 mg Sn/m3SnCl2Rabbit
    WHO 1970
    oral
    10,000
    -----
    44,100 mg Sn/m3
    4,410 mg Sn/m3SnCl2Mouse
    WHO 1972
    oral
    250
    -----
    1,103 mg Sn/m3
    110 mg Sn/m3**Human data:** None relevant for use in determining the revised IDLH.
 
 **Revised IDLH:** 100 mg Sn/m3**Basis for revised IDLH:** No inhalation toxicity data are available on which to base an IDLH for inorganic tin compounds. Therefore, the revised IDLH for inorganic tin compounds is 100 mg Sn/m3 based on acute oral toxicity data in animals [WHO 1972]. This may be a conservative value due to the lack of relevant acute inhalation toxicity data for workers.**REFERENCES:**
1. ACGIH [1971]. Tin (inorganic compounds except SnH4 and SnO2) as Sn. In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 257.
2. Calvery HO [1942]. Trace elements in foods. Food Res *7*:313-331.
3. Flury F, Zernik F [1935]. Zusammenstellung der toxischen und letalen dosen fur die gebrauchlichsten gifte und versuchstiere. Abder Hand Biol Arbeitsmethod *4*:1289-1422 (in German).
4. Gig Sanit [1986]; *51*(6):82 (in Russian).
5. ILO [1972]. Tin, alloys, compounds. In: Encyclopaedia of occupational health and safety. 2nd ed. Vol. II (L-Z). Geneva, Switzerland: International Labour Office, pp. 1407-1409.
6. NIOSH [1976]. XP87000. Tin(II) chloride (1:2). In: Registry of toxic effects of chemical substances, 1976 ed. Cincinnati, OH: U.S. Department of Health, Education, and Welfare, Public Health Service, Center for Disease Control, National Institute for Occupational Safety and Health, DHEW (NIOSH) Publication No. 76-191, p. 1156.
7. Patenko [1886]. Arch de Phys Ser III *7*:33. [From Flury F, Zernik F [1935]. Zusammenstellung der toxischen und letalen dosen fur die gebrauchlichsten gifte und versuchstiere. Abder Hand Biol Arbeitsmethod *4*:1289-1422 (in German).]
8. WHO [1970]. Toxicological evaluation of some extraction solvents and certain other substances. Geneva, Switzerland: World Health Organization, Food and Agriculture Organization, Nutrition Meetings Report Series *48a*:75-77.
9. WHO [1972]. Toxicological evaluation of some enzymes, modified starches and certain other substances. Geneva, Switzerland: World Health Organization, Food and Agriculture Organization, WHO Food Additives Series, No. 1, pp. 101-104.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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