EXHIBIT 21

List of Worldwide Subsidiaries of Angiotech Pharmaceuticals, Inc. as of March 12, 2010

Structure of ownership and control:

Angiotech Pharmaceuticals, Inc. wholly owns all of the below mentioned entities.



|                                                            |  |                             
|----------------------------------------------------------- |  | ----------------------------
|Subsidiary Name                                             |  | Jurisdiction of Organization
|0741693 B.C. Ltd.                                           |  | British Columbia            
|0761717 B.C. Ltd.                                           |  | British Columbia            
|3091796 Nova Scotia Company                                 |  | Nova Scotia                 
|3091799 Nova Scotia Company                                 |  | Nova Scotia                 
|Afmedica, Inc.                                              |  | Delaware                    
|American Medical Instruments Holdings, Inc. d/b/a Angiotech |  | Delaware                    
|Angiodevice International GmbH                              |  | Switzerland                 
|Angiotech America, Inc.                                     |  | Illinois                    
|Angiotech BioCoatings Corp. d/b/a Angiotech                 |  | New York                    
|Angiotech Capital, LLC                                      |  | Nevada                      
|Angiotech Danmark A/S                                       |  | Denmark                     
|Angiotech Delaware, Inc. d/b/a Angiotech                    |  | Delaware                    
|Angiotech Florida Holdings, Inc.                            |  | Delaware                    
|Angiotech GmbH                                              |  | Germany                     
|Angiotech International AG                                  |  | Switzerland                 
|Angiotech International Holdings, Corp.                     |  | Nova Scotia                 
|Angiotech Investment Partnership                            |  | British Columbia            
|Angiotech Italy S.r.l.                                      |  | Italy                       
|Angiotech Participações do Brasil Ltda.                     |  | Brazil                      
|Angiotech Pharmaceuticals (US), Inc. d/b/a Angiotech        |  | Washington                  
|Angiotech Pharmaceutical Interventions, Inc.                |  | Delaware                    
|Angiotech Puerto Rico, Inc.                                 |  | Puerto Rico                 
|Angiotech SARL                                              |  | France                      
|Angiotech S.L.                                              |  | Spain                       
|Angiotech Switzerland SA                                    |  | Switzerland                 
|Angiotech Tender Holdings, Inc.                             |  | British Columbia            
|Angiotech UK Ltd.                                           |  | United Kingdom              
|API Canada Holdings, Inc.                                   |  | British Columbia            
|B.G. Sulzle, Inc. d/b/a Angiotech                           |  | Delaware                    
|Bifos AB                                                    |  | Sweden                      
|DOS Trust                                                   |  | British Columbia            
|Manan Medical Products, Inc. d/b/a Angiotech                |  | Delaware                    
|Medical Device Technologies, Inc. d/b/a Angiotech           |  | Delaware                    
|NeuColl, Inc.                                               |  | Delaware                    
|PBN Medicals Denmark A/S                                    |  | Denmark                     
|Pearsalls Development Limited                               |  | United Kingdom              
|Pearsalls Limited                                           |  | United Kingdom              
|Quill Medical, Inc.                                         |  | Delaware                    
|Soldiers Field Liquidity Management LLC                     |  | Hungary                     
|Surgical Specialties Corporation d/b/a Angiotech            |  | Delaware                    
|Surgical Specialties Puerto Rico, Inc. d/b/a Angiotech      |  | Puerto Rico                 
|Surgical Specialties UK Holdings Limited                    |  | United Kingdom