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Isopropylamine																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 75–31–0
**NIOSH REL:** The 1989 OSHA PEL may not be protective to workers.
**Current OSHA PEL:** 5 ppm (12 mg/m3) TWA
**1989 OSHA PEL:** 5 ppm (12 mg/m3) TWA, 10 ppm (24 mg/m3) STEL
**1993-1994 ACGIH TLV:** 5 ppm (12 mg/m3) TWA, 10 ppm (24 mg/m3) STEL
**Description of substance:** Colorless liquid with an ammonia-like odor.
**LEL:** . . Unknown
**Original (SCP) IDLH:** 4,000 ppm
**Basis for original (SCP) IDLH:** The chosen IDLH is based on the statement by ACGIH [1971] that 0 of 6 rats died from a 4-hour exposure to 4,000 ppm and 6 of 6 rats died after a 4-hour exposure to 8,000 ppm [Smyth et al. 1951]. No other quantitative data are available on which to base the IDLH.
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA:**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50(ppm)**
    **LCLo(ppm)**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived value**Rat
    NCI 1974
    4,000
    -----
    4 hr
    8,000 ppm (2.0)
    800 ppmMouse
    Shell 1961
    -----
    7,000
    40 min
    7,630 ppm (1.09)
    763 ppmRat
    Smyth et al. 1951
    LC100: 8,000
    -----
    4 hr
    16,000 ppm (2.0)
    1,600 ppm**Other animal data:** It has been reported that rats have survived an exposure to 4,000 ppm for 4 hours [Smyth et al. 1951].
 **Human data:** Volunteers have complained of nose and throat irritation after brief exposures to concentrations ranging from 10 to 20 ppm [Amoore and Hautala 1983].
 
 **Revised IDLH:** 750 ppm **Basis for revised IDLH:** The revised IDLH for isopropylamine is 750 ppm based on acute inhalation toxicity data in animals [NCI 1974; Shell 1961]. This may be a conservative value due to the lack of relevant acute toxicity data for workers exposed to concentrations above 20 ppm.**REFERENCES:**
1. ACGIH [1971]. Isopropylamine. In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 141-142.
2. Amoore JE, Hautala E [1983]. Odor as an aid to chemical safety: odor threshold compared with threshold limit values and volatilities for 214 industrial chemicals in air and water dilution. J Appl Toxicol *3*(6):272-290.
3. NCI [1974]. Memorandum (June 17, 1974). Interagency Collaborative Group on Environmental Carcinogenesis, National Cancer Institute.
4. Shell [1961]. Unpublished report. New York, NY: Shell Chemical Corporation, p. 7.
5. Smyth HF Jr, Carpenter CP, Weil CS [1951]. Range-finding toxicity data: list IV. AMA Arch Ind Hyg Occup Med *4*:119-122.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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