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Nitrotoluene (o-, m-, p-isomers)																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS numbers:** 88-72-2 (o-isomer), 99-08-1 (m-isomer), 99-99-0 (p-isomer)
**NIOSH REL:** 2 ppm (11 mg/m3) TWA [skin]
**Current OSHA PEL:** 5 ppm (30 mg/m3) TWA [skin]
**1989 OSHA PEL:** 2 ppm (11 mg/m3) TWA [skin]
**1993-1994 ACGIH TLV:** 2 ppm (11 mg/m3) TWA [skin]
**Description of substance:** Yellow liquids (o-, m-isomers) or a crystalline solid (p-isomer) with weak, aromatic odors.
**LEL(o-isomer):** 2.2% (10% LEL, 2,200 ppm)
**Original (SCP) IDLH:** 200 ppm
**Basis for original (SCP) IDLH:** The chosen IDLH is based on an analogy with nitrobenzene which has an IDLH of 200 ppm.
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA:**
**Lethal dose data:**

**Species**
    **Reference**
    **Route**
    **LD50** **(mg/kg)**
    **LDLo** **(mg/kg)**
    **Adjusted** **LD**
    **Derived value**o-isomer Rat
    Vasilerko et al. 1978
    oral
    891
    -----
    1,094 ppm
    109 ppmo-isomer Mouse
    Vasilerko et al. 1978
    oral
    970
    -----
    1,191 ppm
    119 ppmo-isomer Rabbit
    Vasilerko et al. 1978
    oral
    1,750
    -----
    2,149 ppm
    215 ppmp-isomer Mouse
    Back et al. 1972
    oral
    1,231
    -----
    1,512 ppm
    151 ppmp-isomer Rat
    Vasilerko et al. 1978
    oral
    1,960
    -----
    2,407 ppm
    241 ppmp-isomer Rabbit
    Vasilerko et al. 1978
    oral
    1,750
    -----
    2,149 ppm
    215 ppm**Human data:** It has been stated that nitrotoluene is only slightly toxic, especially in comparison with nitrobenzene [Linch 1974].
 
 **Revised IDLH:** 200 ppm [Unchanged] **Basis for revised IDLH:** Based on acute oral toxicity data in animals [Back et al. 1972; Vasilerko et al. 1978] and an analogy to nitrobenzene [Linch 1974] which has an IDLH of 200 ppm, the original IDLH for nitrotoluene (200 ppm) is not being revised at this time.**REFERENCES:**
1. Back KC, Thomas AA, MacEwen JD [1972]. Reclassification of materials listed as transportation health hazards. Wright-Patterson Air Force Base, OH: 6570th Aerospace Medical Research Laboratory, Report No. TSA-20-72-3, pp. A-310 to A-311.
2. Linch AL [1974]. Biological monitoring for industrial exposure to cyanogenic aromatic nitro and amino compounds. Am Ind Hyg Assoc J *35*:426-432.
3. Vasilerko NM, Kovalenko EE, Batuzina TS [1978]. Experimental substantiation of hygienic concentrations of isomers of mononitrotoluenes in the air of the working zone. Gig Tr Prof Zabol *22*(7):52 (in Russian).

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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