Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link


Centers for Disease Control and Prevention. CDC twenty four seven. Saving Lives, Protecting People
					Search
		×
			NIOSH
			NIOSH
				All CDC
				Submit
			For a full list of topics:A-Z Index
			Advanced Search
		Advanced Search


The National Institute for Occupational Safety and Health (NIOSH)


Facebook
        Twitter
        LinkedIn
        Syndicate





Oxygen difluoride																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 7783–41–7
**NIOSH REL:** 0.05 ppm (0.1 mg/m3) CEILING
**Current OSHA PEL:** 0.05 ppm (0.1 mg/m3) TWA
**1989 OSHA PEL:** 0.05 ppm (0.1 mg/m3) CEILING
**1993-1994 ACGIH TLV:** 0.05 ppm (0.11 mg/m3) CEILING
**Description of substance:** Colorless gas with a peculiar, foul odor.
**LEL:** . . Nonflammable Gas
**Original (SCP) IDLH:** 0.5 ppm
**Basis for original (SCP) IDLH:** The chosen IDLH is based on the statements by Deichmann and Gerarde [1969] that oxygen difluoride is a strong irritant to the entire respiratory tract and causes pulmonary edema and hemorrhage when inhaled for a few hours at 0.5 ppm. Development of pulmonary signs leading to death may be delayed several hours after the exposure [Deichmann and Gerarde 1969]. In addition, AIHA [1967] reported that the Committee on Toxicology of the National Research Council recommended an Emergency Exposure Limit (EEL) of 0.5 ppm for a 10-minute exposure. This EEL is supposed to be for exposures that are “rare in the lifetime of an individual and permit some degree of reversible injury short of incapacitation” [Smyth 1966].
**Existing short-term exposure guidelines:** National Research Council (NRC) Emergency Exposure Limits (EELs) recommended to military and space agencies [Smyth 1966]:
10-minute EEL: 0.5 ppm
30-minute EEL: 0.2 ppm
60-minute EEL: 0.1 ppm
**ACUTE TOXICITY DATA:**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50 (ppm)**
    **LCLo (ppm)**
    **Time**
    **Adjusted 0.5-hr LC (CF)**
    **Derived value**Rat MouseDogMonkey
    Darmer et al. 1972 Darmer et al. 1972Darmer et al. 1972Darmer et al. 1972
    2.6 1.52616
    ----- ---------------
    1 hr 1 hr1 hr1 hr
    3.3 ppm (1.25) 1.9 ppm (1.25)33 ppm (1.25)20 ppm (1.25)
    0.3 ppm 0.2 ppm3.3 ppm2.0 ppm**Human data:** Oxygen difluoride is a strong irritant to the entire respiratory tract and causes pulmonary edema and hemorrhage when inhaled for a few hours at 0.5 ppm [Deichmann and Gerarde 1969].
 
 **Revised IDLH:** 0.5 ppm [Unchanged] **Basis for revised IDLH:** Based on acute inhalation toxicity data in humans [Deichmann and Gerarde 1969], the original IDLH for oxygen difluoride (0.5 ppm) is not being revised at this time.**REFERENCES:**
1. AIHA [1967]. Oxygen difluoride. In: Hygienic guide series. Am Ind Hyg Assoc J *28*:194-196.
2. Darmer KI Jr, Haum CC, MacEwen JD [1972]. The acute inhalation toxicology of chlorine pentafluoride. Am Ind Hyg Assoc J *33*:661-668.
3. Deichmann WB, Gerarde HW [1969]. Oxygen difluoride (OF2). In: Toxicology of drugs and chemicals. New York, NY: Academic Press, Inc., p. 444.
4. Smyth HF Jr [1966]. Military and space short-term inhalation standards. Arch Environ Health *12*:488-490.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
Pinterest
Twitter
YouTube
 NIOSH Homepage NIOSH A-Z
Workplace Safety & Health Topics
Publications and Products
Programs
Contact NIOSH


About CDC
					Contact Us
					800-232-4636
 Facebook Twitter Instagram LinkedIn Youtube Pinterest Snapchat
 CONTACT CDC
				Contact Us
							Call 800-232-4636
							Email Us
			ABOUT CDC
				About CDC
							Jobs
							Funding
			POLICIES
				Accessibility
							External Links
							Privacy
							Policies
							No Fear Act
							FOIA
							OIG
							Nondiscrimination
							Vulnerability Disclosure Policy
			CONNECT WITH US
				Facebook
								Twitter
								Instagram
								LinkedIn
							Youtube
								Pinterest
								Snapchat
								Email
			LANGUAGES
				Español
							繁體中文
							Tiếng Việt
							한국어
							Tagalog
							Русский
							العربية
							Kreyòl Ayisyen
							Français
							Polski
							Português
							Italiano
							Deutsch
							日本語
							فارسی
							English


U.S. Department of Health & Human Services
			Accessibility
			External Links
			Privacy
			Policies
			No Fear Act
			FOIA
			Nondiscrimination
			OIG
			Vulnerability Disclosure Policy
			USA.gov


Exit Notification/Disclaimer Policy Close
 Links with this icon  indicate that you are leaving the CDC website. The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website.
					Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website.
					You will be subject to the destination website's privacy policy when you follow the link.
					CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website. Website Disclaimers
 Cancel Continue