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Mining Publication: Association of IL-6 with PM2.5 Components: Importance of Characterizing Filter-based PM2.5 Following Extraction
Keywords: Filter dust collectors Particulate matter measures
Original creation date: January 2017
Authors: C Roper, LG Chubb, L Cambal, B Tunno, J Clougherty, C Fattman, SE Mischler
Peer Reviewed Journal Article - January 2017
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NIOSHTIC2 Number: 20049119
Water Air Soil Pollut 2017 Jan; 228(1):43
Filter-based toxicology studies are conducted to establish the biological plausibility of the well-established health impacts associated with fine particulate matter (PM2.5) exposure. Ambient PM2.5 collected on filters is extracted into solution for toxicology applications, but frequently, characterization is nonexistent or only performed on filter-based PM2.5, without consideration of compositional differences that occur during the extraction processes. To date, the impact of making associations to measured components in ambient instead of extracted PM2.5 has not been investigated. Filter-based PM2.5 was collected at locations (*n* = 5) and detailed characterization of both ambient and extracted PM2.5 was performed. Alveolar macrophages (AMJ2-C11) were exposed (3, 24, and 48 h) to PM2.5 and the pro-inflammatory cytokine interleukin (IL)-6 was measured. IL-6 release differed significantly between PM2.5 collected from different locations; surprisingly, IL-6 release was highest following treatment with PM2.5 from the lowest ambient concentration location. IL-6 was negatively correlated with the sum of ambient metals analyzed, as well as with concentrations of specific constituents which have been previously associated with respiratory health effects. However, positive correlations of IL-6 with extracted concentrations indicated that the negative associations between IL-6 and ambient concentrations do not accurately represent the relationship between inflammation and PM2.5 exposure. Additionally, seven organic compounds had significant associations with IL-6 release when considering ambient concentrations, but they were not detected in the extracted solution. Basing inflammatory associations on ambient concentrations that are not necessarily representative of in vitro exposures creates misleading results; this study highlights the importance of characterizing extraction solutions to conduct accurate health impact research.
First page of Association of IL-6 with PM2.5 Components: Importance of Characterizing Filter-based PM2.5 Following ExtractionPeer Reviewed Journal Article - January 2017
Go to Web Page
NIOSHTIC2 Number: 20049119
Water Air Soil Pollut 2017 Jan; 228(1):43
See Also
Diesel Exhaust Aerosol, Review of Measurement Technology
Differential Pressure Response of 25-mm-Diameter Glass Fiber Filters Challenged with Coal and Limestone Dust Mixtures
Instrumentation for Diesel Particulate Matter Emissions Research
Morphological and Elemental Classification of Freshly Emitted Soot Particles and Atmospheric Ultrafine Particles using the TEM/EDS
NIOSH Hazard ID 1 - Exposure to Silica Dust on Continuous Mining Operations Using Flooded-Bed Scrubbers
Real-Time DPM Ambient Monitoring in Underground Mines
Ringelmann Smoke Chart
Role of Lubrication Oil in Particulate Emissions from a Hydrogen-Powered Internal Combustion Engine
Sampling Results of the Improved SKC� Diesel Particulate Matter Cassette
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Page last reviewed: December 8, 2017
Page last updated: December 8, 2017
Content source: National Institute for Occupational Safety and Health, Mining Program
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