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Isobutyl alcohol																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 78–83–1
**NIOSH REL:** 50 ppm (150 mg/m3) TWA
**Current OSHA PEL:** 100 ppm (300 mg/m3) TWA
**1989 OSHA PEL:** 50 ppm (150 mg/m3) TWA
**1993-1994 ACGIH TLV:** 50 ppm (152 mg/m3) TWA
**Description of substance:** Colorless, oily liquid with a sweet, musty odor.
**LEL**(@123°F): 1.7% (10% LEL(@123°F), 1,700 ppm)
**Original (SCP) IDLH:** 8,000 ppm
**Basis for original (SCP) IDLH:** The chosen IDLH is based on the statement by Patty [1963] that 2 of 6 rats died when exposed for 4 hours to 8,000 ppm [Smyth et al. 1954].
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA:**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50** **(ppm)**
    **LCLo** **(ppm)**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived value**Rat
    Smyth et al. 1954
    LC33: 8,000
    -----
    4 hr
    16,000 ppm (2.0)
    1,600 ppm**Lethal dose data:**
 
 **Species**
    **Reference**
    **Route**
    **LD50** (mg/kg)
    **LDLo** (mg/kg)
    **Adjusted LD**
    **Derived value**Rabbit Rat
    Munch and Schwartze 1925 Smyth et al. 1954
    oral oral
    ----- -----
    3,750 2,460
    8,522 ppm 5,591 ppm
    852 ppm 559 ppm**Other animal data:** RD50 (mouse), 1,818 ppm [DeCeaurriz et al. 1981].
 **Human data:** None relevant for use in determining the revised IDLH.
 
 **Revised IDLH:** 1,600 ppm **Basis for revised IDLH:** The revised IDLH for isobutyl alcohol is 1,600 ppm based on acute inhalation toxicity data in animals [Smyth et al. 1954]. This may be a conservative value due to the lack of relevant acute toxicity data for workers.**REFERENCES:**
1. DeCeaurriz JC, Micillino JC, Bonnet P, Guenier JP [1981]. Sensory irritation caused by various industrial airborne chemicals. Toxicol Lett *9*(2):137-143.
2. Munch JC, Schwartze EW [1925]. Narcotic and toxic potency of aliphatic alcohols upon rabbits. J Lab Clin Med *10*:985-995.
3. Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 1448.
4. Smyth HF Jr, Carpenter CP, Weil CS, Pozzani UC [1954]. Range-finding toxicity data: list V. AMA Arch Ind Hyg Occup Med *10*:61-68.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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