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Crag® herbicide																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 136–78–7
**NIOSH REL:** 10 mg/m3 (total dust) TWA, 5 mg/m3 (respirable dust) TWA
**Current OSHA PEL:** 15 mg/m3 (total dust) TWA, 5 mg/m3 (respirable dust) TWA
**1989 OSHA PEL:** 10 mg/m3 (total dust) TWA, 5 mg/m3 (respirable dust) TWA
**1993-1994 ACGIH TLV:** 10 mg/m3 TWA
**Description of Substance:** Colorless to white crystalline, odorless solid.
**LEL:** . . Noncombustible Solid
**Original (SCP) IDLH:** 5,000 mg/m3
**Basis for original (SCP) IDLH:** According to many sources, Crag® herbicide is not very toxic to mammals. Because no acute inhalation toxicity data are available, the chosen IDLH has been estimated from the rat oral LD50 of 730 mg/kg [Gunther 1962 cited by NIOSH 1976].
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA**
**Lethal dose data:**

**Species**
    **Reference**
    **Route**
    **LD50** **(mg/kg)**
    **LDLo** **(mg/kg)**
    **Adjusted LD**
    **Derived value**Rat RatMammal
    Carpenter et al. 1961 Gunther 1962Sine 1991
    oral oraloral
    480 7301,230
    ----- ----------
    3,360 mg/m35,110 mg/m38,610 mg/m3
    336 mg/m3511 mg/m3861 mg/m3
 **Human data:** None relevant for use in determining the revised IDLH.
 
 **Revised IDLH:** 500 mg/m3**Basis for revised IDLH:** No inhalation toxicity data are available on which to base an IDLH for Crag® herbicide. Therefore, the revised IDLH for Crag® herbicide is 500 mg/m3 based on acute oral toxicity data in animals [Carpenter et al. 1961; Gunther 1962; Sine 1991]. This may be a conservative value due to the lack of acute toxicity data for workers.
**REFERENCES:**
1. Carpenter CP, Weil CS, Smyth HF Jr. [1961]. Mammalian toxicity of sesone herbicide. J Agri Food Chem *9*:382-385
2. Gunther FA, ed. [1962]. Residues of pesticides and other foreign chemicals in food and feeds. Vol. I. Secaucus, NJ: Springer Verlag New York, Inc., p. 18.
3. NIOSH [1976]. KK49000. Ethanol, 2-(2,4-dichlorophenoxy)-, hydrogen sulfate, sodium salt. In: Registry of toxic effects of chemical substances, 1976 ed. Cincinnati, OH: U.S. Department of Health, Education, and Welfare, Public Health Service, Center for Disease Control, National Institute for Occupational Safety and Health, DHEW (NIOSH) Publication No. 76-191, p. 503.
4. Sine C, ed. [1991]. Sesone. In: Farm chemicals handbook ’91, p. C273.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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