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Difluorodibromomethane																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 75–61–6
**NIOSH REL:** 100 ppm (860 mg/m3) TWA
**Current OSHA PEL:** 100 ppm (860 mg/m3) TWA
**1989 OSHA PEL:** Same as current PEL
**1993-1994 ACGIH TLV:** 100 ppm (858 mg/m3) TWA
**Description of Substance:** Colorless, heavy liquid or gas (above 76 F) with a characteristic odor.
**LEL:**. . Noncombustible Liquid/Nonflammable Gas
**Original (SCP) IDLH:** 2,500 ppm
**Basis for original (SCP) IDLH:** The chosen IDLH is based on the rat LCLO of 2,300 ppm [Comstock et al. 1953 cited by NIOSH 1974] and on the statement by Patty [1963] that 4,000 ppm for 15 minutes caused significant pulmonary damage in rats [Chambers et al. 1950].
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50** **(ppm)**
    **LCLo** **(ppm)**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived** **value**Mouse Rat
    Chambers et al. 1950 Comstock and Oberst 1952
    ----- -----
    54,630 55,000
    15 min 15 min
    43,158 ppm (0.79) 43,450 ppm (0.79)
    4,316 ppm 4,345 ppm
 **Other animal data:** It has been reported that 4,000 ppm for 15 minutes caused significant pulmonary damage in rats [Chambers et al. 1950]. Fatalities were noted in rats after exposures of to 2,300 ppm for 6 hours/day, 5 days/week for 7 weeks [Comstock et al. 1953].
 **Human data:** None relevant for use in determining the revised IDLH.
 
 **Revised IDLH:** 2,000 ppm **Basis for revised IDLH:** The revised IDLH for difluorodibromomethane is 2,000 ppm based on inhalation toxicity data in animals [Chambers et al. 1950; Comstock et al. 1953].
**REFERENCES:**
1. Chambers WH, Krachow EH, McGroth FP, Goldberg SB, Lawson LH, McNamee K [1950]. An investigation of the toxicity of proposed fire extinguishing fluids. Part III. The pathology in rats produced by inhalation of vapors of proposed fire extinguishing compounds. Army Chemical Center, MD: U.S. Army Chemical Corps, Medical Division Research Report No. 23, p. 33.
2. Comstock CC, Oberst FW [1952]. Comparative inhalation toxicities of carbon tetrachloride, monochloromonobromomethane, difluorodibromomethane and trifluoromonobromomethane to rats and mice in the presence of gasoline fires. Army Chemical Center, MD: U.S. Army Chemical Corps Medical Laboratories, Research Report No. 107. p. 52.
3. Comstock CC, Kerschner J, Oberst FW [1953]. Toxicology of inhaled trifluoromonobromomethane and difluorodibromomethane vapors from subacute and chronic exposures of rats and dogs. Army Chemical Center, MD: U.S. Army Chemical Corps, Medical Laboratory Research Report No. 180, p. 6.
4. NIOSH [1974]. PA75250. Methane, dibromodifluoro-. In: The toxic substances list, 1974 ed. Rockville, MD: U.S. Department of Health, Education, and Welfare, Public Health Service, Center for Disease Control, National Institute for Occupational Safety and Health, DHEW (NIOSH) Publication No. 74-134, p. 477.
5. Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 1328.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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