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1-Nitropropane																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 108–03–2
**NIOSH REL:** 25 ppm (90 mg/m3) TWA
**Current OSHA PEL:** 25 ppm (90 mg/m3) TWA
**1989 OSHA PEL:** Same as current PEL
**1993-1994 ACGIH TLV:** 25 ppm (91 mg/m3) TWA
**Description of substance:** Colorless liquid with a somewhat disagreeable odor.
**LEL:** . . 2.2% (10% LEL, 2,200 ppm)
**Original (SCP) IDLH:** 2,300 ppm
**Basis for original (SCP) IDLH:** The chosen IDLH is based on an analogy with 2-nitropropane which has an IDLH of 2,300 ppm. The animal data for 1-nitropropane given in Patty [1963] (i.e., 5,000 ppm for 3 hours killed 2 of 2 rabbits and 2 of 2 guinea pigs; 10,000 ppm for 1 hour killed 0 of 2 rabbits and 2 of 2 guinea pigs [Machle et al. 1940]) have not been used to determine the IDLH for 1-nitropropane because cats, which were far more susceptible to 2-nitropropane than guinea pigs or rabbits, were not used to study the effects of 1-nitropropane.
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA:**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50 (ppm)**
    **LCLo (ppm)**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived value**Rabbit
    Marhold 1986
    LC100: 5,000
    -----
    3 hr
    9,000 ppm (1.8)
    900 ppmRabbit
    Machle et al. 1940
    LC100: 5,000
    -----
    3 hr
    9,000 ppm (1.8)
    900 ppmG. pig
    Machle et al. 1940
    LC100: 5,000
    -----
    3 hr
    9,000 ppm (1.8)
    900 ppmG. pig
    Machle et al. 1940
    LC100: 10,000
    -----
    1 hr
    12,500 ppm (1.25)
    1,250 ppmRat
    NPIRI 1974
    3,100
    -----
    8 hr
    7,750 ppm (2.5)
    775 ppm**Lethal dose data:**
 
 **Species**
    **Reference**
    **Route**
    **LD50 (mg/kg)**
    **LDLo (mg/kg)**
    **Adjusted LD**
    **Derived value**Mouse RabbitRat
    Gig Sanit 1967 Machle 1940NPIRI 1974
    oral oraloral
    800 -----455
    ----- 250-----
    1,514 ppm 473 ppm861 ppm
    151 ppm 47 ppm86 ppm**Other animal data:** It has been reported that rabbits survived a 1-hour exposure to 10,000 ppm [Machle et al. 1940].
 **Human data:** Volunteers found brief exposures to concentrations exceeding 100 ppm to cause eye irritation [Silverman et al. 1946].
 
 **Revised IDLH:** 1,000 ppm **Basis for revised IDLH:** The revised IDLH for 1-nitropropane is 1,000 ppm based on acute inhalation toxicity data in animals [Machle et al. 1940; Marhold 1986; NPIRI 1974]. This may be a conservative value due to the lack of relevant acute toxicity data in workers exposed to concentrations above 100 ppm.**REFERENCES:**
1. Gig Sanit [1967]; *32*(9):9 (in Russian).
2. Machle W, Scott EW, Treon J [1940]. The physiological response of animals to some simple mononitroparaffins and to certain derivatives of these compounds. J Ind Hyg Toxicol *22*(8):315-332.
3. Marhold J [1986]. Prehled Prumyslove Toxikologie, Organicke Latky. Prague, Czechoslovakia: Avicenum, p. 404 (in Czechoslovakian).
4. NPIRI [1974]. Raw materials data handbook, physical and chemical properties, fire hazard and health hazard data. Vol. 1. Organic solvents. Bethlehem, PA: National Printing Ink Research Institute, p. 91.
5. Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., pp. 2077-2078.
6. Silverman L, Schulte HF, First MW [1946]. Further studies on sensory response to certain industrial solvent vapors. J Ind Hyg Toxicol *28*:262-266.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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