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Methyl acrylate																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 96–33–3
**NIOSH REL:** 10 ppm (35 mg/m3) TWA [skin]
**Current OSHA PEL:** 10 ppm (35 mg/m3) TWA [skin]
**1989 OSHA PEL:** Same as current PEL
**1993-1994 ACGIH TLV:** 10 ppm (35 mg/m3) TWA [skin]
**Description of substance:** Colorless liquid with an acrid odor.
**LEL:** . . 2.8% (10% LEL, 2,800 ppm)
**Original (SCP) IDLH:** 1,000 ppm
**Basis for original (SCP) IDLH:** The chosen IDLH is based on the rat 4-hour LC50 of 1,000 ppm in which 3 of 6 rats died [Smyth and Carpenter 1948 cited by Patty 1963].
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA:**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50** **(ppm)**
    **LCLo** **(ppm)**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived value**Mouse RatRatRabbit
    Lomonova & Klimova 1979 Oberly &Tansey 1985Smyth &Carpenter 1948Treon et al. 1949
    3,575 1,3501,0002,522
    ----- ---------------
    ? 4 hr4 hr1 hr
    ? 2,700 ppm (2.0)2,000 ppm (2.0)3,153 ppm (1.25)
    ? 270 ppm200 ppm315 ppm**Other animal data:** Rats exposed 4 hours per day, 5 days per week at 110 ppm for a total of 32 exposures had eye discomfort at the start of the investigation, but no overt signs of respiratory distress or other manifestations of toxicity were recorded [Oberly and Tansey 1985].
 **Human data:** None relevant for use in determining the revised IDLH.
 
 **Revised IDLH:** 250 ppm **Basis for revised IDLH:** The revised IDLH for methyl acrylate is 250 ppm based on acute inhalation data in animals [Oberly and Tansey 1985; Smyth and Carpenter 1948; Treon et al. 1949].**REFERENCES:**
1. Lomonova GV, Klimova EI [1979]. On the toxicity methyl and ethyl acrylates. Gig Tr Prof Zabol *23*(9):55-56 (in Russian).
2. Oberly R, Tansey MF [1985]. LC50 values for rats acutely exposed to vapors of acrylic and methacrylic acid esters. J Toxicol Environ Health *16*:811-822.
3. Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 1880.
4. Smyth HF Jr, Carpenter CP [1948]. Further experience with the range-finding test in the industrial toxicology laboratory. J Ind Hyg Toxicol *30*:63-68.
5. Treon JF, Sigmon H, Wright H, Kitzmiller KV [1949]. The toxicity of methyl and ethyl acrylate. J Ind Hyg Toxicol *31*:317-326.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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