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Tetramethyl succinonitrile																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 3333–52–6
**NIOSH REL:** 3****mg/m3 (0.5 ppm) TWA [skin]
**Current OSHA PEL:** 3 mg/m3 (0.5 ppm) TWA [skin]
**1989 OSHA PEL:** Same as current PEL
**1993-1994 ACGIH TLV:** 2.8 mg/m3 (0.5 ppm) TWA [skin]
**Description of substance:** Colorless, odorless solid.
**LEL**: . Unknown
**Original (SCP) IDLH:** 5 ppm
**Basis for original (SCP) IDLH:** The chosen IDLH is based on the statement by ACGIH [1972] that 6 ppm for 30 hours was lethal to rats [Spolyar 1948]. A concentration of 22 ppm is obviously too high to be chosen as the IDLH, because no mice survived a 3.5-hour exposure at this concentration [Hecht and Kimmerle 1956-1957 as quoted by Reinl 1957].
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA:**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50** **(ppm)**
    **LCLo** **(ppm)**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived value**Mouse
    Hecht &Kimmerle 1956/1957
    -----
    28
    3 hr
    50 ppm (1.8)
    5.0 ppmMouse
    Hecht &Kimmerle 1956/1957
    LC100: 22
    -----
    3.5 hr
    42 ppm (1.9)
    4.2 ppmRat
    Spolyar 1948
    -----
    6
    30 hr
    24 ppm (3.91)
    2.4 ppm**Lethal dose data:**
 
 Species
    **Reference**
    **Route**
    **LD50** **(mg/kg)**
    **LDLo** **(mg/kg)**
    **Adjusted LD**
    **Derived value**Rat
    Johannsen &ivinskas 1986
    oral
    38.9
    -----
    48 ppm
    4.8 ppm**Human data:** None relevant for use in determining the revised IDLH.
 
 **Revised IDLH:** 5 ppm [Unchanged] **Basis for revised IDLH:** Based on acute inhalation toxicity data in animals [Hecht and Kimmerle 1956-1957], the original IDLH for tetramethyl succinonitrile (5 ppm) is not being revised at this time.**REFERENCES:**
1. ACGIH [1972]. Tetramethyl succinonitrile. In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 254.
2. Harger RN, Hupieu HR [1949]. Toxicity of tetramethyl succinonitrile and the antidotal effects of thiosulphate, nitrile, and barbiturates. Fed Proc *8*:205.
3. Hecht G, Kimmerle H [1956/1957]. Toxikologische Untersuchungen uber Tetramethyl-bernsteinsauredinitril. Unpublished investigations (in German). [From Reinl W [1957]. Intoxication in manufacturing of plastics by tetramethyl-succinic acid dinitrile. Arch Toxikol *16*:367-380 (in German).]
4. Johannsen FR, Livinskas GJ [1986]. Subchronic toxicity of tetramethyl succinonitrile. Fundam Appl Toxicol *7*:41-48.
5. Reinl W [1957]. Intoxication in manufacturing of plastics by tetramethyl-succinic acid dinitrile. Arch Toxikol *16*:367-380 (in German).
6. Spolyar LW [1948]. Indiana chemists report toxicity of product of Porofor M. Ind Hyg Newsletter *8*(10)3.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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