Exhibit 4.2

  

   

    

  EXECUTION VERSION

  
    

    

    

    

    

    

    

    

    HUMANA INC.,

    Issuer

    

    

    THE BANK OF NEW YORK MELLON TRUST COMPANY, N.A.,

    Trustee

    

    

    SIXTEENTH SUPPLEMENTAL INDENTURE

    Dated as of March 26, 2020

     

    

    4.500% Senior Notes due 2025

     

    

    

    

    Supplemental to Indenture dated as of August 5, 2003

    

    

    

    

    
      
        


    

    THIS SIXTEENTH SUPPLEMENTAL INDENTURE (the “Sixteenth Supplemental Indenture”) is made the 26th day of
      March, 2020, between HUMANA INC., a corporation duly incorporated and existing under the laws of Delaware and having its principal executive office at 500 West Main Street, Louisville, Kentucky 40202 (hereinafter called “the Company”), and THE BANK
      OF NEW YORK MELLON TRUST COMPANY, N.A. (formerly known as The Bank of New York Trust Company, N.A. and as successor to The Bank of New York), a national banking association, as Trustee (hereinafter called the “Trustee”).

    RECITALS OF THE COMPANY

    WHEREAS, the Company entered into an Indenture, dated as of August 5, 2003 with the Trustee (the
      “Original Indenture,” and together with this Sixteenth Supplemental Indenture, referred to herein as the “Indenture”) (all capitalized terms used in this Sixteenth Supplemental Indenture and not otherwise defined herein have the meanings assigned to
      such terms in the Original Indenture), for the purposes of issuing its Securities, evidencing its senior unsecured indebtedness, unlimited as to principal amount, to bear such rates of interest, to mature at such time or times, to be issued in one or
      more series and to have such other provisions as authorized by or pursuant to the authority granted in one or more resolutions of the Board of Directors of the Company; and

    WHEREAS, Section 901 of the Original Indenture provides that without the consent of the Holders of the
      Securities of any series issued under the Original Indenture, the Company, when authorized by a Board Resolution, and the Trustee may, in certain circumstances, enter into one or more indentures supplemental to the Original Indenture; and

    WHEREAS, the Company proposes to issue a series of Securities designated as its 4.500% Senior Notes due
      2025, the terms of which shall be set forth in, or determined in the manner provided in, an Officers’ Certificate of the Company as provided in Section 301 of the Original Indenture (such senior notes being referred to herein as the “2025 Senior
      Notes” and all references to Securities in the Original Indenture shall be deemed to refer also to the 2025 Senior Notes unless the context otherwise provides); and

    WHEREAS, the entry into this Sixteenth Supplemental Indenture by the parties hereto is in all respect
      authorized by the provisions of the Original Indenture; and

    WHEREAS, all conditions necessary to authorize the execution and delivery of this Sixteenth Supplemental
      Indenture and to make it a valid and binding obligation of the Company have been done or performed; and

    NOW, THEREFORE, THIS SIXTEENTH SUPPLEMENTAL INDENTURE WITNESSETH:

    For and in consideration of the promises and the purchase of the 2025 Senior Notes by the Holders
      thereof, it is mutually covenanted and agreed, for the equal and proportionate benefit of all Holders of the 2025 Senior Notes, as follows:

    Section 1.  The Original Indenture is hereby amended solely with respect to the
        2025 Senior Notes as follows:

    
      	
              (A)

            	
              By amending Section 101 to insert the following definitions in their entirety in the appropriate alphabetical
                order as follows:

            


    

    “Change of Control” means the occurrence of any one of the following: (1) the direct or indirect sale,
      lease, transfer, conveyance or other disposition (other than by way of merger or consolidation), in one or a series of related transactions, of all or substantially all of the Company’s and its subsidiaries assets taken as a whole to any Person other
      than to the Company or a Subsidiary; (2) the consummation of any transaction (including without limitation, any merger or consolidation) the result of which is that any Person becomes the “beneficial owner” (as defined in Rules 13d-3 and 13d-5 under
      the Exchange Act), directly or indirectly, of more than 50% of the outstanding Voting Stock of the Company or the Voting Stock of any Parent Company (as defined below) or other Voting Stock into which the Voting Stock of the Company or the Voting
      Stock of any Parent Company is reclassified, consolidated, exchanged or changed, measured by voting power rather than number of shares; (3) the Company or any Parent Company consolidates with, or merges with or into, any Person, or any Person
      consolidates with, or merges with or into, the Company or any Parent Company, in any such event pursuant to a transaction in which any of the outstanding Voting Stock of the Company, the Voting Stock of such Parent Company or the Voting Stock of such
      other Person is converted into or exchanged for cash, securities or other property, other than any such transaction where the shares of the Voting Stock of the Company or the Voting Stock of such Parent Company outstanding immediately prior to such
      transaction constitute, or are converted into or exchanged for, a majority of the Voting Stock of the surviving Person or any Parent Company of the surviving Person immediately after giving effect to such transaction; or (4) the adoption of a plan
      relating to the liquidation or dissolution of the Company. Notwithstanding the foregoing, a transaction will not be deemed to involve a Change of Control under clause (2) above if (i) the Company becomes a subsidiary of a Parent Company and (ii) the
      holders of the Voting Stock of the Company or the Voting Stock of any Parent Company immediately prior to such transaction hold at least a majority of the Voting Stock of such Parent Company immediately following such transaction; provided that any
      series of related transactions shall be treated as a single transaction. The term “Person,” solely as used in this definition, has the meaning given thereto in Section 13(d)(3) of the Exchange Act.

    “Change of Control Triggering Event” means the occurrence of both a Change of Control and a related
      Rating Event.

    “Common Stock” means, with respect to any Principal Subsidiary, Capital Stock of any class, however
      designated, except Capital Stock which is non-participating beyond fixed dividend and liquidation preferences and the holders of which have either no voting rights or limited voting rights entitling them, only in the case of certain contingencies, to
      elect less than a majority of the directors (or persons performing similar functions) of such Principal Subsidiary, and also includes securities of any class, however designated, which are convertible into Common Stock.

    “Indebtedness” means, with respect to any Person (without duplication):

    
      	
              (1)

            	
              any liability of that Person (A) for borrowed money, or under any reimbursement obligation
                relating to a letter of credit or similar instrument; (B) evidenced by a bond, note, debenture or similar instrument; (C) to pay the deferred purchase price of property or services, except trade accounts payable arising in the ordinary
                course of business; or (D) for the payment of money relating to any obligations under any capital lease of real or personal property which has been recorded as a capitalized lease obligation;

            


    

    
      	
              (2)

            	
              any liability of others described in the preceding clause (1) that the Person has guaranteed
                or that is otherwise its legal liability or which is secured by a lien on that Person’s Property; and

            


    

    
      	
              (3)

            	
              any amendment, supplement, modification, deferral, renewal, extension or refunding of any
                liability of the types referred to in clauses (1) or (2) above.

            


    

    “Investment Grade” means a rating of Baa3 or better by Moody’s (or its equivalent under any successor
      rating category) and a rating of BBB- or better by S&P Global Ratings (or its equivalent under any successor rating category).

    “Issue Date” means the first date on which 2025 Senior Notes are issued, which shall be March 26, 2020.

    “Moody’s” means Moody’s Investors Service, Inc., or any successor thereto.

    “Parent Company” means any holding company that, directly or indirectly, owns 100% of the Voting Stock
      of the Company.

    “Principal Subsidiary” means a consolidated subsidiary of the Company that, as of the relevant time of
      determination, is a “significant subsidiary” as defined under Rule 405 under the Securities Act of 1933, as amended (as that Rule is in effect on March 23, 2020, without giving effect to any further amendment of that Rule).

    “Rating Agency” means:

    
      	
              (1)

            	
              each of Moody’s and S&P Global Ratings, and

            


    

    
      	
              (2)

            	
              if either or both of Moody’s or S&P Global Ratings ceases to rate the 2025 Senior Notes or
                fails to make a rating of the 2025 Senior Notes publicly available for reasons outside of the Company’s control, a Substitute Rating Agency in lieu thereof.

            


    

    “Rating Event” means (i) the rating of the 2025 Senior Notes is lowered by both Rating Agencies during
      the related Trigger Period and (ii) the 2025 Senior Notes are rated below an Investment Grade rating by both Rating Agencies on any day during such Trigger Period. If either Rating Agency is not providing a rating of the 2025 Senior Notes on any day
      during such Trigger Period for any reason, the rating of such Rating Agency shall be deemed to be below Investment Grade on such day and such Rating Agency will be deemed to have lowered its rating of the 2025 Senior Notes during the Trigger Period. 
      For the avoidance of doubt, the Trustee shall not be charged with knowledge of any Rating Event nor have any duty to monitor the ratings of the Securities.

    “S&P Global Ratings” means S&P Global Ratings, acting through Standard & Poor’s Financial
      Services LLC, a division of S&P Global Inc., or any successor thereto.

    “Substitute Rating Agency” means a “nationally recognized statistical rating organization” as that term
      is defined in Section 3(a)(62) of the Exchange Act, selected by the Company (as certified by a resolution of the Board of Directors delivered to the Trustee) as a replacement agency for Moody’s or S&P Global Ratings, or both of them, as the case
      may be.

    “Trigger Period” means the period commencing on the earlier of the first public notice of (a) the
      occurrence of a Change of Control or (b) the Company’s intention to effect a Change of Control and ending 60 days following consummation of such Change of Control (which period shall be extended so long as the rating of the 2025 Senior Notes is under
      publicly announced consideration for a possible downgrade by either of the Rating Agencies).

    “Voting Stock” means, with respect to any Person as of any date, the Capital Stock of such Person that
      is at the time entitled to vote generally in the election of the board of directors (or other analogous managing body) of such Person.

    
      	
              (B)

            	
              By replacing the definition of “Notice of Default” in Section 101 of the Original Indenture in its entirety as
                follows:

            


    

    “Notice of Default” has the meaning specified in Sections 501(3) and 501(4).

    
      	
              (C)

            	
              By replacing Section 105(2) of the Original Indenture in its entirety as follows:

            


    

    (2) the Company by such Trustee or by any Holder shall be sufficient for every purpose hereunder (except as provided in paragraphs (3) and (4) of
        Section 501) if furnished in writing and mailed, first class postage prepaid, addressed to it, to the attention of the Chief Financial Officer, at the address of its principal office specified in the first paragraph of this instrument or at any
        other address previously furnished in writing to such Trustee by the Company, or if sent by facsimile transmission, to a facsimile number provided to the Trustee by the Company, with a copy mailed, first class postage prepaid, to the Company
        addressed to it as provided above.

    
      	
              (D)

            	
              By deleting the eighth paragraph of Section 305 of the Original Indenture in its entirety.

            


    

    
      	
              (E)

            	
              By replacing Section 403 of the Original Indenture in its entirety as follows:

            


    

    Section 403. Covenant
        Defeasance.

    Upon the Company’s exercise under Section 401 of the option applicable to this
      Section 403, the Company shall be released from any obligations under the covenants contained in Sections 704, 801 and 1007 hereof with respect to the Outstanding 2025 Senior Notes, on and after the date the conditions set forth in Section 404 are
      satisfied (hereinafter, “Covenant Defeasance”), and the 2025 Senior Notes and any coupons appertaining thereto shall thereafter be deemed not “Outstanding” for the purposes of any direction, waiver, consent or declaration or act of Holders (and the
      consequences of any thereof) in connection with such covenants, but shall continue to be deemed “Outstanding” for all other purposes hereunder (it being understood that such 2025 Senior Notes shall not be deemed outstanding for accounting purposes).
      For this purpose, such Covenant Defeasance means that, with respect to the Outstanding 2025 Senior Notes and any coupons appertaining thereto, the Company may omit to comply with and shall have no liability in respect of any term, condition or
      limitation set forth in any such covenant, whether directly or indirectly, by reason of any reference elsewhere herein to any such covenant or by reason of any reference in any such covenant to any other provision herein or in any other document and
      such omission to comply shall not constitute a default or Event of Default under subsection 501(3) but, except as specified above, the remainder of this Indenture and the 2025 Senior Notes shall be unaffected thereby.

    
      	
              (F)

            	
              By replacing Section 404(b) of the Original Indenture in its entirety as follows:

            


    

    (b) in the case of Legal Defeasance, the Company shall have delivered to the Trustee for the Securities of that series an Opinion of Counsel in
        the United States reasonably acceptable to such Trustee confirming that, subject to customary assumptions and exclusions, (1) the Company has received from, or there has been published by, the U.S. Internal Revenue Service a ruling or (2) since the
        Issue Date, there has been a change in the applicable U.S. federal income tax law, in either case to the effect that, and based thereon such Opinion of Counsel in the United States shall confirm that, subject to customary assumptions and
        exclusions, the Holders and beneficial owners of the Outstanding Securities of that series will not recognize income, gain or loss for U.S. federal income tax purposes as a result of such Legal Defeasance and will be subject to U.S. federal income
        tax on the same amounts, in the same manner and at the same times as would have been the case if such Legal Defeasance had not occurred;

    
      	
              (G)

            	
              By replacing Section 404(c) of the Original Indenture in its entirety as follows:

            


    

    (c) in the case of Covenant Defeasance, the Company shall have delivered to the Trustee for the Securities of that series an Opinion of Counsel
        in the United States reasonably acceptable to such Trustee confirming that, subject to customary assumptions and exclusions, the Holders and beneficial owners of the Outstanding Securities of that series will not recognize income, gain or loss for
        U.S. federal income tax purposes as a result of such Covenant Defeasance and will be subject to U.S. federal income tax on the same amounts, in the same manner and at the same times as would have been the case if such Covenant Defeasance had not
        occurred;

    
      	
              (H)

            	
              By replacing Section 404(d) of the Original Indenture in its entirety as follows:

            


    

    (d) no Event of Default or event which with the giving of notice or the lapse of time, or both, would become an Event of Default with respect to
        the 2025 Senior Notes shall have occurred and be continuing on the date of such deposit and no Event of Default under Section 501(5) or Section 501(6) shall have occurred and be continuing on the 123rd day after such date;

    
      	
              (I)

            	
              By replacing Section 405(ii)(B) of the Original Indenture in its entirety as follows:

            


    

    (B) no Event of Default or event which with the giving of notice or the lapse of time, or both, would become an Event of Default shall have
        occurred and be continuing on the date of such deposit and no Event of Default under Section 501(5) or Section 501(6) shall have occurred and be continuing on the 123rd day after such date;

    
      	
              (J)

            	
              By replacing Section 501 of the Original Indenture in its entirety as follows:

            


    

    “Event of Default” wherever used herein with respect to the 2025 Senior Notes means any one of the
      following events (whatever the reason for such Event of Default and whether it shall be voluntary or involuntary or be effected by operation of law pursuant to any judgment, decree or order of any court or any order, rule or regulation of any
      administrative or governmental body):

    
      	
              (1)

            	
              default in the payment of any installment of interest upon any 2025 Senior Note and any
                related coupon when it becomes due and payable, and continuance of such default for a period of 30 days; or

            


    

    
      	
              (2)

            	
              default in the payment of the principal of (or premium, if any, on) any 2025 Senior Note at
                its Maturity; or

            


    

    
      	
              (3)

            	
              default in the performance of, or breach of, any covenant or warranty of the Company in
                respect of any 2025 Senior Note contained in this Indenture or in such 2025 Senior Notes (other than a covenant or warranty a default in whose performance or whose breach is elsewhere in this Section specifically dealt with) and continuance
                of such default or breach for a period of 60 days after there has been given, by registered or certified mail, to the Company by the Trustee for the 2025 Senior Notes or to the Company and such Trustee by the Holders of at least 25% in
                aggregate principal amount of the Outstanding 2025 Senior Notes a written notice specifying such default or breach and requiring it to be remedied and stating that such notice is a “Notice of Default” hereunder; or

            


    

    
      	
              (4)

            	
              (A) the Company or any of its Subsidiaries fails to pay indebtedness for money borrowed by the
                Company or any of its Subsidiaries in an aggregate principal amount of at least $150,000,000, at the later of final maturity or the expiration of any related applicable grace period and such payment shall not have been made, waived or
                extended within 30 days after written notice from the Trustee or the Holders of at least 25% in aggregate principal amount of the Outstanding 2025 Senior Notes as provided below or (B) acceleration of maturity of Securities of another
                series or any other indebtedness for borrowed money of the Company or any of its Subsidiaries, in an aggregate principal amount exceeding $150,000,000, under the terms of the instrument or instruments under which such indebtedness arises or
                is secured, if such indebtedness has not been discharged in full or such acceleration is not rescinded or annulled within 30 days after there has been given, by registered or certified mail, to the Company by the Trustee or to the Company
                and such Trustee by the Holders of at least 25% in aggregate principal amount of the Outstanding 2025 Senior Notes a written notice specifying such default and requiring it to be remedied and stating that such notice is a “Notice of Default” hereunder; or

            


    

    
      	
              (5)

            	
              the Company shall commence any case or proceeding seeking to have an order for relief entered
                on its behalf as debtor or to adjudicate it as bankrupt or insolvent or seeking reorganization, liquidation, dissolution, winding-up, arrangement, composition or readjustment of its debts or any other relief under any bankruptcy,
                insolvency, reorganization, liquidation, dissolution, arrangement, composition, readjustment of debt or other similar act or law of any jurisdiction, domestic or foreign, now or hereafter existing; or the Company shall apply for a receiver,
                custodian or trustee (other than any trustee appointed as a mortgagee or secured party in connection with the issuance of indebtedness for borrowed money of the Company) of it or for all or a substantial part of its property; or the Company
                shall make a general assignment for the benefit of creditors; or the Company shall take any corporate action in furtherance of any of the foregoing; or

            


    

    
      	
              (6)

            	
              an involuntary case or other proceeding shall be commenced against the Company with respect to
                it or its debts under any bankruptcy, insolvency or other similar law now or hereafter in effect seeking the appointment of a trustee, receiver, liquidator, custodian or similar official of the Company or any substantial part of its
                property; and such case or other proceeding (A) results in the entry of an order for relief or a similar order against the Company or (B) shall continue unstayed and in effect for a period of 60 consecutive days.

            


    

    
      	
              (K)

            	
              By replacing the first and second paragraphs of Section 502 of the Original Indenture in their entirety as
                follows:

            


    

    If an Event of Default with respect to the 2025 Senior Notes and any related coupons
      occurs and is continuing (other than an Event of Default described in Section 501(5) or 501(6) with respect to the Company), then and in every such case either the Trustee for the 2025 Senior Notes or the Holders of not less than 25% in aggregate
      principal amount of the Outstanding 2025 Senior Notes may declare the entire principal amount of all the 2025 Senior Notes, to be due and payable immediately, by a notice in writing to the Company (and to such Trustee if given by Holders), and upon
      any such declaration of acceleration such principal, together with accrued interest and all other amounts owing hereunder, shall become immediately due and payable, without presentment, demand, protest or notice of any kind, all of which are hereby
      expressly waived.

    If any Event of Default specified in Section 501(5) or 501(6) occurs with respect to
      the Company, all of the unpaid principal amount and accrued interest on all Securities of each series then outstanding shall ipso facto become and be
      immediately due and payable without any declaration or other act by the Trustee or any Holder.

    
      	
              (L)

            	
              By replacing the last paragraph of Section 607 of the Original Indenture in its entirety as follows:

            


    

    When the Trustee incurs expenses or renders services in connection with an Event of
      Default specified in Section 501(5) or Section 501(6) the expenses (including the reasonable charges and expenses of its counsel) and the compensation for the services are intended to constitute expenses of administration under any applicable Federal
      or state bankruptcy, insolvency or other similar law.

    
      	
              (M)

            	
              By replacing Section 1007 of the Original Indenture in its entirety as follows:

            


    

    Section 1007. Limitation
        on Liens

    The Company shall not, and shall not permit any of its Principal Subsidiaries to,
      issue, assume, Incur or guarantee any Indebtedness secured by a mortgage, pledge, lien or other encumbrance, directly or indirectly, on any of the Common Stock of a Principal Subsidiary owned by the Company or any of its Principal Subsidiaries,
      unless the Company’s obligations under the 2025 Senior Notes and, if the Company so elects, any other Indebtedness of the Company ranking on a parity with, or prior to, the 2025 Senior Notes, shall be secured equally and ratably with, or prior to,
      such secured Indebtedness so long as it is outstanding and is so secured.

    
      	
              (N)

            	
              By replacing Section 1008 of the Original Indenture in its entirety as follows:

            


    

    Section 1008. Waiver
        of Certain Covenants.

    The Company may omit in any particular instance to comply with any covenant or
      condition set forth in Sections 1005 to 1007, inclusive, if before or after the time for such compliance the Holders of more than 50% in aggregate principal amount of the Outstanding Securities of each series of Securities affected by the omission
      shall, in each case by Act of such Holders, either waive such compliance in such instance or generally waive compliance with such covenant or condition, but no such waiver shall extend to or affect such covenant or condition except to the extent so
      expressly waived, and, until such waiver shall become effective, the obligations of the Company and the duties of the Trustee for the Securities of each series with respect to any such covenant or condition shall remain in full force and effect.

    
      	
              (O)

            	
              By deleting Section 1009 from the Original Indenture in its entirety.

            


    

    
      	
              (P)

            	
              By adding Section 1109 to the Original Indenture as follows:

            


    

    Section 1109.  Offer to Repurchase Upon Change of Control Triggering Event.

    
      
        	

              	(a)	
                If a Change of Control Triggering Event occurs with respect to the 2025 Senior Notes, unless the Company shall have exercised its option to redeem the 2025 Senior Notes
                  pursuant to Section 1102, the Company shall be required to make an offer (the “Change of Control Offer”) to each Holder of 2025 Senior Notes to repurchase all or any part (equal to $2,000 or any integral multiple of $1,000 in excess
                  thereof) of such Holder’s 2025 Senior Notes on the terms set forth in this Section 1109. In the Change of Control Offer, the Company shall be required to offer payment in cash equal to 101% of the principal amount of the 2025 Senior Notes
                  to be repurchased, plus accrued and unpaid interest, if any, on the 2025 Senior Notes up to, but not including, the date of repurchase (the “Change of
                  Control Payment”) subject to the rights of the Holder on the relevant Regular Record Date to receive interest due on the relevant Interest Payment Date. Within 30 days following any Change of Control Triggering Event or, at the option of
                  the Company, prior to any Change of Control, but after the public announcement of the transaction that constitutes or may constitute the Change of Control, the Company shall deliver a notice to Holders of the 2025 Senior Notes, with a
                  copy to the Trustee, which notice shall govern the terms of the Change of Control Offer, describing the transaction that constitutes or may constitute the Change of Control Triggering Event and offering to repurchase the 2025 Senior Notes
                  on the date specified in the notice, which date shall be no earlier than 15 days and no later than 60 days from the date such notice is sent other than as may be required by law or, if the notice is sent prior to the Change of Control, no
                  earlier than 15 days and no later than 60 days from the date on which the Change of Control Triggering Event occurs (the “Change of Control Payment Date”). The notice shall, if sent prior to the date of consummation of the Change of
                  Control, state that the Change of Control Offer is conditioned on the Change of Control Triggering Event occurring on or prior to the Change of Control Payment Date.

              


      

    

    (b) On the Change of Control Payment Date, the Company shall, to the extent lawful:

    
      
        	

              	(i)	
                accept for payment all 2025 Senior Notes or portions of 2025 Senior Notes properly tendered pursuant to the Change of Control Offer;

              


      

    

    
      
        	

              	(ii)	
                deposit with the Paying Agent an amount equal to the Change of Control Payment in respect of all 2025 Senior Notes or portions of 2025 Senior Notes properly tendered in
                  accordance with the procedures set forth in the Global Securities representing the 2025 Senior Notes; and

              


      

    

    
      
        	

              	(iii)	
                deliver or cause to be delivered to the Trustee the 2025 Senior Notes properly accepted together with an Officer’s Certificate stating the principal amount of 2025 Senior
                  Notes or portions of 2025 Senior Notes being repurchased.

              


      

    

    The Company shall publicly announce the results of the Change of Control Offer on or as soon as possible
      after the date of purchase.

    
      
        	

              	(c)	
                The Company shall not be required to make a Change of Control Offer upon the occurrence of a Change of Control Triggering Event if a third party makes such an offer in the
                  manner, at the times and otherwise in compliance with the requirements for an offer made by the Company and the third party repurchases all 2025 Senior Notes properly tendered and not withdrawn under its offer.

              


      

    

    
      
        	

              	(d)	
                The Company shall comply in all material respects with the requirements of Rule 14e-1 under the Exchange Act and any other securities laws and regulations thereunder to
                  the extent such laws and regulations are applicable in connection with the repurchase of the 2025 Senior Notes as a result of a Change of Control Triggering Event. To the extent that the provisions of any such securities laws or
                  regulations conflict with the Change of Control Offer provisions of the 2025 Senior Notes, the Company shall comply with the applicable securities laws and regulations and shall not be deemed to have breached its obligations under this
                  Section 1109 by virtue of any such conflict.

              


      

    

    Section 2.  The recitals and statements in this Sixteenth Supplemental Indenture
        are made by the Company only and not by the Trustee, and the Trustee makes no representation as to the validity or sufficiency of this Sixteenth Supplemental Indenture (other than with respect to the due authorization, execution and delivery of
        this Sixteenth Supplemental Indenture by the Trustee).  All of the provisions contained in the Original Indenture in respect of the rights, privileges, immunities, powers and duties of the Trustee shall be applicable in respect of the 2025 Senior
        Notes and of this Sixteenth Supplemental Indenture as fully and with like effect as if set forth herein in full.

    Section 3.  As supplemented hereby, the Original Indenture is in all respects
        ratified and confirmed, and the Original Indenture and this Sixteenth Supplemental Indenture shall be read, taken and construed as one and the same instrument and all references to Securities in the Original Indenture shall be deemed to refer also
        to the 2025 Senior Notes unless the context otherwise provides.

    Section 4.  This Sixteenth Supplemental Indenture shall be governed by, and
        construed in accordance with, the laws of the State of New York.

    Section 5.  In the event of a conflict between the terms and conditions of the
        Original Indenture and the terms and conditions of this Sixteenth Supplemental Indenture, then the terms and conditions of this Sixteenth Supplemental Indenture shall prevail; provided that if and to the extent that any provision of this Sixteenth
        Supplemental Indenture limits, qualifies or conflicts with another provision which is required to be included herein or in the Original Indenture by the Trust Indenture Act of 1939, as amended, such required provision shall control.

    Section 6.  All covenants and agreements in this Sixteenth Supplemental Indenture
        by the Company shall bind its successors and assigns, whether so expressed or not.

    Section 7.  In case any provision in this Sixteenth Supplemental Indenture shall be
        invalid, illegal or unenforceable, the validity, legality and enforceability of the remaining provisions shall not in any way be affected or impaired hereby.

    Section 8.  Nothing in this Sixteenth Supplemental Indenture, expressed or implied,
        shall give to any Person, other than the parties hereto and any Paying Agent, any Security Registrar and any Authenticating Agent for the 2025 Senior Notes and their successors under the Indenture, and the Holders of the 2025 Senior Notes any
        benefit or any legal or equitable right, remedy or claim under this Sixteenth Supplemental Indenture.

    Section 9.  This Sixteenth Supplemental Indenture may be simultaneously executed in
        several counterparts, each of which shall be deemed to be an original, and such counterparts shall together constitute but one and the same instrument.

    (signature page follows)

    
      
        


    

    IN WITNESS WHEREOF, the parties hereto have caused this Sixteenth Supplemental Indenture dated as of March 26, 2020 to be
      duly executed, all as of March 26, 2020.

    

    

    	
            HUMANA INC.,

            Issuer

          
	 	 	 
	
            By

          	 	
            
              /s/ Brian A. Kane

               

            

          
	
            Name:

          	 	
            Brian A. Kane

          
	
            Title:

          	 	
            Chief Financial Officer

          


    

    

    
      [Signature Page to Sixteenth Supplemental Indenture]

    

    
      
        


    

    

    

    	
            THE BANK OF NEW YORK MELLON TRUST COMPANY, N.A.,

              Trustee

          
	 	 	 
	
            By

          	 	
            
              /s/ Mark Petro

               

            

          
	
            Name:

          	 	
            Mark Petro

          
	
            Title:

          	 	
            Vice President

          
	 	 	 
	
            Dated:

          	 	
            March 26, 2020

          


    
       

      

       

      

       

      

       

      

      [Signature Page to Sixteenth Supplemental Indenture]