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p-Nitroaniline																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 100–01–6
**NIOSH REL:** 3 mg/m3 TWA [skin]
**Current OSHA PEL:** 6 mg/m3 (1 ppm) TWA [skin]
**1989 OSHA PEL:** 3 mg/m3 TWA [skin]
**1993-1994 ACGIH TLV:** 3 mg/m3 TWA [skin]
**Description of substance:** Bright yellow, crystalline powder with a slight ammonia-like odor.
**LEL:** . . . Unknown
**Original (SCP) IDLH:** 300 mg/m3
**Basis for original (SCP) IDLH:** The chosen IDLH (300 mg/m3 or 50 ppm) is based on an analogy with aniline and the statement by AIHA [1955] that 50 to 100 ppm aniline can probably be tolerated for 1 hour. Although the IDLH chosen for aniline was 100 ppm, the IDLH of 50 ppm (300 mg/m3) chosen for p-nitroaniline is reasonable because Von Oettingen [1941] stated that p-nitroaniline is more toxic than aniline.
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA:**
**Lethal dose data:**

**Species**
    **Reference**
    **Route**
    **LD50** **(mg/kg)**
    **LDLo** **(mg/kg)**
    **Adjusted LD**
    **Derived value**Rat RatG. pigMouse
    Back et al. 1972 Matrka et al. 1978Moskalenko 1966Vernot et al. 1977
    oral oraloraloral
    3,249 750450810
    ----- ---------------
    22,743 mg/m35,250 mg/m33,150 mg/m35,670 mg/m3
    2,274 mg/m3525 mg/m3315 mg/m3567 mg/m3**Human data:** None relevant for use in determining the revised IDLH.
 
 **Revised IDLH:** 300 mg/m3 [Unchanged] **Basis for revised IDLH:** No inhalation toxicity data are available on which to base an IDLH for p-nitroaniline. Therefore, based on acute oral toxicity data in animals [Matrka et al. 1978; Moskalenko 1966; Vernot et al. 1977], the original IDLH for p-nitroaniline (300 mg/m3) is not being revised at this time.**REFERENCES:**
1. AIHA [1955]. Aniline. In: Hygienic guide series. Am Ind Hyg Assoc Q *16*:331-332.
2 Back KC, Thomas AA, MacEwen JD [1972]. Reclassification of materials listed as transportation health hazards. Wright-Patterson Air Force Base, OH: 6570th Aerospace Medical Research Laboratory, Report No. TSA-20-72-3, pp. A-298 to A-299.
3. Matrka M, Rambousek V, Zverina Z [1978]. Toxicity of p-substituted derivatives of aniline in experimental rats. Ceskoslovenska Hygiena (Czechoslovak Hygiene) *23*:168-172 (in Czechoslovakian).
4. Moskalenko EG [1966]. Toxicological characteristics of nitroanilines. Vop Komm Gig 6:89-94 (in Russian).
5. Vernot EH, MacEwen JD, Haun CC, Kinkead FR [1977]. Acute toxicity and skin corrosion data for some organic and inorganic compounds and aqueous solutions. Toxicol Appl Pharmacol *42*:417-423.
6. von Oettingen WF [1941]. The aromatic amino and nitro compounds, their toxicity and potential dangers. Public Health Bulletin *271*:34.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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