Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link


Centers for Disease Control and Prevention. CDC twenty four seven. Saving Lives, Protecting People
					Search
		×
			NIOSH
			NIOSH
				All CDC
				Submit
			For a full list of topics:A-Z Index
			Advanced Search
		Advanced Search


The National Institute for Occupational Safety and Health (NIOSH)


Facebook
        Twitter
        LinkedIn
        Syndicate





Methylene bisphenyl isocyanate (MDI)																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 101–68–8
**NIOSH REL:** 0.05 mg/m3 (0.005 ppm) TWA,
0.2 mg/m3 (0.020 ppm) 10-minute CEILING
**Current OSHA PEL:** 0.2 mg/m3 (0.02 ppm) CEILING
**1989 OSHA PEL:** Same as current PEL
**1993-1994 ACGIH TLV:** 0.051 mg/m3 (0.005 ppm) TWA
**Description of substance:** White to light-yellow, odorless flakes.
**LEL:** . . Unknown
**Original (SCP) IDLH:** 100 mg/m3
**Basis for original (SCP) IDLH:** The chosen IDLH is based on an analogy with toluene diisocyanate, which has an IDLH of 10 ppm. [Note: A concentration of 10 ppm methylene bisphenyl isocyanate is equivalent to about 100 mg/m3.]
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA:**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50**
    **LCLo**
    **Time**
    **Adjusted 0.5-hr LC (CF)**
    **Derived value**Rat
    Bunge et al. 1977
    369 mg/m3
    -----
    4 hr
    738 mg/m3 (2.0)
    74 mg/m3Rat
    Bunge et al. 1977
    380 mg/m3
    -----
    4 hr
    760 mg/m3 (2.0)
    76 mg/m3Rat
    Woolrich 1982
    178 mg/m3
    -----
    ?
    ?
    ?**Lethal dose data:**
 
 **Species**
    **Reference**
    **Route**
    **LD50 (mg/kg)**
    **LDLo (mg/kg)**
    **Adjusted LD**
    **Derived value**Mouse
    Izmerov et al. 1982
    oral
    2,200
    -----
    15,400 mg/m3
    1,540 mg/m3Rat
    Woolrich 1982
    oral
    -----
    31,690
    221,830 mg/m3
    22,183 mg/m3**Human data:** None relevant for use in determining the revised IDLH.
 
 **Revised IDLH:** 75 mg/m3**Basis for revised IDLH:** The revised IDLH for methylene bisphenyl isocyanate is 75 mg/m3 based on acute inhalation toxicity data in animals [Bunge et al. 1977].**REFERENCES:**
1. Bunge W, Ehrlicher H, Kimmerle G [1977]. Medical aspects of work with surface coating systems using the spraying technique. Zentralbl Arbeitsmed Arbeitsschutz Prophylaxe *4*(spec. ed.):1-46 (in German). [From ACGIH [1991]. Methylene bisphenyl isocyanate. In: Documentation of the threshold limit values and biological exposure indices. 6th ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 978-980.]
2. Izmerov NF, Sanotsky IV, Sidorov KK [1982]. Toxicometric parameters of industrial toxic chemicals under single exposure. Moscow, Russia: Centre of International Projects, GKNT, p. 63.
3. Woolrich PF [1982]. Industrial hygiene and medical control of TDI, MDI and PMPPI. Am Ind Hyg Assoc J *43*(2):89-97.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
Pinterest
Twitter
YouTube
 NIOSH Homepage NIOSH A-Z
Workplace Safety & Health Topics
Publications and Products
Programs
Contact NIOSH


About CDC
					Contact Us
					800-232-4636
 Facebook Twitter Instagram LinkedIn Youtube Pinterest Snapchat
 CONTACT CDC
				Contact Us
							Call 800-232-4636
							Email Us
			ABOUT CDC
				About CDC
							Jobs
							Funding
			POLICIES
				Accessibility
							External Links
							Privacy
							Policies
							No Fear Act
							FOIA
							OIG
							Nondiscrimination
							Vulnerability Disclosure Policy
			CONNECT WITH US
				Facebook
								Twitter
								Instagram
								LinkedIn
							Youtube
								Pinterest
								Snapchat
								Email
			LANGUAGES
				Español
							繁體中文
							Tiếng Việt
							한국어
							Tagalog
							Русский
							العربية
							Kreyòl Ayisyen
							Français
							Polski
							Português
							Italiano
							Deutsch
							日本語
							فارسی
							English


U.S. Department of Health & Human Services
			Accessibility
			External Links
			Privacy
			Policies
			No Fear Act
			FOIA
			Nondiscrimination
			OIG
			Vulnerability Disclosure Policy
			USA.gov


Exit Notification/Disclaimer Policy Close
 Links with this icon  indicate that you are leaving the CDC website. The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website.
					Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website.
					You will be subject to the destination website's privacy policy when you follow the link.
					CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website. Website Disclaimers
 Cancel Continue