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2-Ethoxyethyl acetate																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 111–15–9
**NIOSH REL:** 0.5 ppm (2.7 mg/m3) TWA [skin]
**Current OSHA PEL:** 100 ppm (540 mg/m3) TWA [skin]
**1989 OSHA PEL:** Same as current PEL
**1993-1994 ACGIH TLV:** 5 ppm (27 mg/m3) TWA [skin]
**Description of Substance:** Colorless liquid with a mild odor.
**LEL:**. . 1.7% (10% LEL, 1,700 ppm)
**Original (SCP) IDLH:** 2,500 ppm
**Basis for original (SCP) IDLH:** Patty [1963] reported that guinea pigs survived a 1-hour exposure to an atmosphere essentially saturated with vapor (estimated to be less than 4,000 ppm) [Lehmann and Flury 1943]. Because the data concerning the concentration is not very specific, the IDLH is based on the concentration of 2-ethoxyethylacetate in saturated air at 20 C (i.e., 2,600 ppm).
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50** **(ppm)**
    **LCLo** **(ppm)**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived** **value**Rat RatRabbit
    Pozzani et al. 1959 Smyth et al. 1941Truhaut et al. 1979
    2,204 LC33: 1,500>2,000
    ----- ----------
    8 hr 8 hr4 hr
    5,510 ppm (2.5) 3,750 ppm (2.5)>4,000 ppm (2.0)
    551 ppm 375 ppm>400 ppm
 **Lethal dose data:**
 
 **Species**
    **Reference**
    **Route**
    **LD50** **(mg/kg)**
    **LDLo** **(mg/kg)**
    **Adjusted LD**
    **Derived value**Rabbit RatG. pig
    Eastman 1982 Isin et al. 1988Smyth et al. 1941
    oral oraloral
    1,950 2,7001,910
    ----- ----------
    2,486 ppm 3,443 ppm2,435 ppm
    249 ppm 344 ppm243 ppm
 **Human data:** None relevant for use in determining the revised IDLH.
 
 **Revised IDLH:** 500 ppm **Basis for revised IDLH:** The revised IDLH for 2-ethoxyethyl acetate is 500 ppm based on acute inhalation toxicity data in animals [Pozzani et al. 1959; Smyth et al. 1941; Truhaut et al. 1979]. This may be a conservative value due to the lack of relevant inhalation acute toxicity data for workers.
**REFERENCES:**
1. Eastman Company [1982]. 8(e) submission to U.S. Environmental Protection Agency. Kingsport, TN: Tennessee Eastman Company, Status Report 8EHQ-0682-0450.
2. Isin OV, Plaksienko NF, et al. [1988]. Hygienic reglamentation of cellosolve content in water bodies. Gig Sanit *53*(10):78-79 (in Russian).
3. Lehmann KB, Flury F, eds. [1943]. Toxicology and hygiene of industrial solvents. Translated by E. King and H.F. Smyth, Jr. Baltimore, MD: Williams & Wilkins Company, p. 290.
4. Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 1589.
5. Pozzani UC, Weil CS, Carpenter CP [1959]. The toxicological basis of threshold limit values: 5. The experimental inhalation of vapor mixtures by rats, with notes upon the relationship between single dose inhalation and single dose oral data. Am Ind Hyg Assoc J *20*:364-369.
6. Smyth HF Jr, Seaton J, Fischer L [1941]. The single dose toxicity of some glycols and derivatives. J Ind Hyg Toxicol *23*:259-268.
7. Truhaut R, Dutertre-Catella H, Phu-Lich N, Huyen VN [1979]. Comparative toxicological study of ethylglycol acetate and butylglycol acetate. Toxicol Appl Pharmacol *51*:117-127.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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