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Styrene																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 100–42–5
**NIOSH REL:** 50 ppm (215 mg/m3) TWA, 100 ppm (425 mg/m3) STEL
**Current OSHA PEL:** 100 ppm TWA, 200 ppm CEILING,
600 ppm 5-minute MAXIMUM PEAK IN ANY 3 HOURS
**1989 OSHA PEL:** 50 ppm (215 mg/m3) TWA, 100 ppm (425 mg/m3) STEL
**1993-1994 ACGIH TLV:** 50 ppm (213 mg/m3) TWA,
100 ppm (426 mg/m3) CEILING [skin]
**Description of substance:** Colorless to yellow, oily liquid with a sweet, floral odor.
**LEL:** . . . 0.9% (10% LEL, 900 ppm)
**Original (SCP) IDLH:** 5,000 ppm
**Basis for original (SCP) IDLH:** The chosen IDLH is based on the statement by Patty [1963] that rats and guinea pigs exposed to 5,000 ppm become unconscious within 1 hour [Spencer et al. 1942].
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA:**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50** **(ppm)**
    **LCLo** **(ppm)**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived value**Mouse
    Izmerov et al. 1982
    2,194
    -----
    4 hr
    4,388 ppm (2.0)
    439 ppmHuman
    Lefaux 1978
    -----
    10,000
    30 min
    10,000 ppm (1.0)
    1,000 ppmG. pig
    Spencer et al. 1942
    -----
    2,771
    14 hr
    8,314 ppm (3.0)
    831 ppmRat
    Tiunov et al. 1982
    5,543
    -----
    4 hr
    11,085 ppm (2.0)
    1,109 ppm**Other animal data:** RD50 (mouse), 980 ppm [Alarie 1981].
 **Other human data:** Volunteers exposed to 376 ppm for up to 7 hours experienced unpleasant subjective symptoms and objective signs of neurologic impairment [Stewart et al. 1968]. Drowsiness, nausea, headache, fatigue, and dizziness have been reported in workers exposed to 200 to 700 ppm [AIHA 1959].
 
 **Revised IDLH:** 700 ppm **Basis for revised IDLH:** The revised IDLH for styrene is 700 ppm based on acute inhalation toxicity data in humans [AIHA 1959; Stewart et al. 1968].**REFERENCES:**
1. AIHA [1959]. Styrene monomer. In: Hygienic guide series. Akron, OH: American Industrial Hygiene Association.
2. Alarie Y [1981]. Dose-response analysis in animal studies: prediction of human responses. Environ Health Perspect *42*:9-13.
3. Izmerov NF, Sanotsky IV, Sidorov KK [1982]. Toxicometric parameters of industrial toxic chemicals under single exposure. Moscow, Russia: Centre of International Projects, GKNT, p. 106.
4. Lefaux R [1978]. Practical toxicology of plastics. Cleveland, OH: Chemical Rubber Co., p. 77.
5. Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 1230.
6. Spencer HC, Irish DD, Adams EM, Rowe VK [1942]. The response of laboratory animals to monomeric styrene. J Ind Hyg Toxicol *24*(10):295-296.
7. Stewart RD, Dodd HC, Baretta ED, Schaffer AW [1968]. Human exposure to styrene vapor. Arch Environ Health *16*:656-662.
8. Tiunov LA, Zhuvov VG, et al. [1982]. Toxicity of sulfothreenaphtilenfurane. Gig Tr Prof Zabol *26*(8):53-56 (in Russian).

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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