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Xylidine																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 1300–73–8 (mixed isomers)
**NIOSH REL:** 2 ppm (10 mg/m3) TWA [skin]
**Current OSHA PEL:** 5 ppm (25 mg/m3) TWA [skin]
**1989 OSHA PEL:** 2 ppm (10 mg/m3) TWA [skin]
**1993-1994 ACGIH TLV:** 0.5 ppm (2.5 mg/m3) TWA [skin], A2
**Description of substance:** Pale-yellow to brown liquid with a weak, aromatic, amine-like odor.
**LEL:** . . 1.0% (10% LEL, 1,000 ppm)
**Original (SCP) IDLH:** 150 ppm
**Basis for original (SCP) IDLH:** The chosen IDLH is based on the mouse 7-hour LC50 of 149 ppm [von Oettingen et al. 1947 cited by ACGIH 1971].
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA:**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50** **(ppm)**
    **LCLo** **(ppm)**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived value**Mice (2,4-)
    von Oettingen et al. 1947
    149
    -----
    7 hr
    358 ppm (2.4)
    36 ppm**Lethal dose data:**
 
 **Species**
    **Reference**
    **Route**
    **LD50** **(mg/kg)**
    **LDLo** **(mg/kg)**
    **Adjusted LD**
    **Derived value**Rabbit
    Deichmann & Gerarde 1969
    oral
    -----
    600
    833 ppm
    83 ppmRat
    Treon et al. 1949
    oral
    -----
    610
    847 ppm
    85 ppmRat (2,3-)
    Vernot et al. 1977
    oral
    -----
    930
    1,292 ppm
    129 ppmMouse (2,3-)
    Vernot et al. 1977
    oral
    -----
    1,070
    1,486 ppm
    149 ppmRat (2,4-)
    Vernot et al. 1977
    oral
    -----
    470
    653 ppm
    65 ppmMouse (2,4-)
    Vernot et al. 1977
    oral
    -----
    250
    347 ppm
    35 ppmRat (2,4-)
    Lindstrom et al. 1969
    oral
    -----
    1,259
    1,749 ppm
    175 ppmRat (2,5-)
    Vernot et al. 1977
    oral
    -----
    1,300
    1,806 ppm
    181 ppmMouse (2,5-)
    Vernot et al. 1977
    oral
    -----
    840
    1,167 ppm
    117 ppmRat (2,6-)
    Vernot et al. 1977
    oral
    -----
    1,230
    1,708 ppm
    171 ppmMouse (2,6-)
    Vernot et al. 1977
    oral
    -----
    710
    986 ppm
    99 ppmRat (2,6-)
    Short et al. 1983
    oral
    -----
    1,050
    1,458 ppm
    146 ppmRat (3,4-)
    Vernot et al. 1977
    oral
    -----
    810
    1,125 ppm
    113 ppmMouse (3,4-)
    Vernot et al. 1977
    oral
    -----
    710
    986 ppm
    99 ppmRat (3,5-)
    Vernot et al. 1977
    oral
    -----
    710
    986 ppm
    99 ppmMouse (3,5-)
    Vernot et al. 1977
    oral
    -----
    420
    583 ppm
    58 ppm**Human data:** None relevant for use in determining the revised IDLH.
 
 **Revised IDLH:** 50 ppm **Basis for revised IDLH:** The revised IDLH for xylidine is 50 ppm based on acute toxicity data in animals [Deichmann and Gerarde 1969; Treon et al. 1949; Vernot et al. 1977; von Oettingen et al. 1947]. This may be a conservative value due to the lack of relevant acute toxicity data for workers.**REFERENCES:**
1. ACGIH [1971]. Xylidine. In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 282-283.
2. Deichmann WB, Gerarde HW [1969]. Xylidine (aminodimethylbenzene). Toxicology of drugs and chemicals. New York, NY: Academic Press, Inc., p. 637.
3. Lindstrom HV, Bowie WG, Wallace WG, et al. [1969]. The toxicity and metabolism of mesidine and pseudodocumidine in rats. J Pharmacol Exp Ther *167*:223. [From ACGIH [1991]. Xylidine. In: Documentation of the threshold limit values and biological exposure indices. 6th ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 1743-1745.]
4. Short CR, King C, Sistrunk PW, Kerr KM [1983]. Subacute toxicity of several ring-substituted dialkylanilines in the rat. Fundam Appl Toxicol *3*(4):285-292.
5. Treon JF, Deichmann WB, Sigmon HE, Wright H, Witherup SO, Heyro FF, Kitzmiller KV, Kelnan C [1949]. The toxic properties of xylidine and monomethylaniline. I. The comparative toxicity of xylidine and monomethyaniline when administered orally or intravenously to animals or applied upon their skin. J Ind Hyg Toxicol *31*:1-18.
6. Vernot EH, MacEwen ID, Haun GG, Kinkead ER [1977]. Acute toxicity and skin corrosion data for some organic and inorganic compounds and aqueous solutions. Toxicol Appl Pharmacol *42*(2):417-423.
7. von Oettingen WF, Neal PA, Sievers RF, Svirbely JL, Monaco AR, Horecker BL, Yagoda H, Sweeney TR, Peterson DC, Alford WC, Hauff VB, Gay H [1947]. Xylidine (c,c-dimethylaniline): its toxicity and potential dangers as compared with those of aniline and an appraisal of the potential hazards from its use in blending gasoline. NIH Bulletin *188*:88.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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