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o-Dichlorobenzene																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 95–50–1
**NIOSH REL:** 50 ppm (300 mg/m3) CEILING
**Current OSHA PEL:** 50 ppm (300 mg/m3) CEILING
**1989 OSHA PEL:** Same as current PEL
**1993-1994 ACGIH TLV:** 25 ppm (150 mg/m3) TWA, 50 ppm (301 mg/m3) STEL
**Description of Substance:** Colorless to pale-yellow liquid with a pleasant, aromatic odor.
**LEL:**. . 2.2% (10% LEL, 2,200 ppm)
**Original (SCP) IDLH:** 1,000 ppm
**Basis for original (SCP) IDLH:** The chosen IDLH is based on the statement by ACGIH [1971] that 1,000 ppm was fatal to guinea pigs after 20 hours [Browning 1953]. ACGIH [1971] also reported that Cameron et al. [1937] found liver damage in animals after exposure for a few hours at 50 to 800 ppm.
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50** **(ppm)**
    **LCLo** **(ppm)**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived** **value**G. pig G. pigRat
    Browning 1953 Cameron et al. 1937Hollingsworth et al. 1958
    ----- ----------
    1,000 800821
    20 hr 24 hr7 hr
    3,450 ppm (3.45) 2,880 ppm (3.6)1,970 ppm (2.4)
    345 ppm 288 ppm197 ppm
 **Lethal dose data:**
 
 **Species**
    **Reference**
    **Route**
    **LD50** **(mg/kg)**
    **LDLo** **(mg/kg)**
    **Adjusted LD**
    **Derived value**Rat G. pigRabbitMouse
    Ben-Dyke et al. 1970 Patty 1963Thomson 1976/77Yakkyoku 1981
    oral oraloraloral
    500 2,0005004,386
    ----- ---------------
    573 ppm 2,291 ppm573 ppm5,025 ppm
    57 ppm 229 ppm57 ppm503 ppm
 **Other animal data:** RD50 (mouse), 182 ppm [DeCeaurriz et al. 1981].
 **Human data:** Concentrations up to 100 ppm have been reported to have caused sporadic irritation of the eyes and respiratory tract [Elkins 1959].
 
 **Revised IDLH:** 200 ppm **Basis for revised IDLH:** The revised IDLH for o-dichlorobenzene is 200 ppm based on acute inhalation toxicity data in animals [Hollingsworth et al. 1958]. This may be a conservative value due to the lack of relevant acute toxicity data for workers exposed to concentrations above 100 ppm.
**REFERENCES:**
1. ACGIH [1971]. o-Dichlorobenzene. In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 76.
2. Ben-Dyke R, Sanderson DM, Noakes DN [1970]. Acute toxicity data for pesticides (1970). World Review of Pesticide Control *9*:119-127.
3. Browning E [1953]. Toxicity of industrial organic solvents. New York, NY: Chemical Publishing Company, p. 190.
4. Cameron GR, Thomas JC, Ashmore SA, Buchan JL, Warren EH, Hughes AWM [1937]. The toxicity of certain chlorine derivatives of benzene, with special reference to o-dichlorobenzene. J Pathol Bacteriol *44*(2):281-296.
5. DeCeaurriz JC, Micillino JC, Bonnet P, Guenier JP [1981]. Sensory irritation caused by various industrial airborne chemicals. Toxicol Lett *9*(2):137-143.
6. Elkins HB [1959]. The chemistry of industrial toxicology. 2nd ed. New York, NY: John Wiley & Sons, Inc., p. 150.
7. Hollingsworth RL, Rowe VK, Oyen F, Torkelson TR, Adams EM [1958]. Toxicity of o-dichlorobenzene. AMA Arch Ind Health *17*:180-187.
8. Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 1336.
9. Thomson WT [1976/77]. Agricultural chemicals. Fresno, CA: Thomas Publications, *3*:32.
10. Yakkyoku (Pharmacy) [1981]; *32*:471-474 (in Japanese).

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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