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2-Aminopyridine																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 504-29-0
**NIOSH REL:** 0.5 ppm (2 mg/m3) TWA
**Current OSHA PEL:** 0.5 ppm (2 mg/m3) TWA
**1989 OSHA PEL:** Same as current PEL
**1993-1994 ACGIH TLV:** 0.5 ppm (1.9 mg/m3) TWA
**Description of substanceL:** White powder, leaflets, or crystals with a characteristic odor.
**LEL:** Unknown
**Original (SCP) IDLH:** 5 ppm
**Basis for original (SCP) IDLH:** Very little quantitative data are available on which to base an IDLH for 2-aminopyridine. The chosen IDLH is based on the statement by ACGIH [1971] that a 5-hour exposure to about 5 ppm produced headache, increased blood pressure, and nausea in a worker [Watrous and Schulz 1950].
**Short-term exposure guidelines:** None developed
ACUTE TOXICITY DATA
**Lethal dose data:**
LL50
    LCLo
    
    DerivedSpecies
    Reference
    Route
    (mg/kg)
    (mg/kg)
    Adjusted LD
    ValueRat
    Marhold 1986
    oral
    200
    -----
    385 ppm
    39 ppmMouse
    Verschueren 1983
    oral
    50
    -----
    90 ppm
    9 ppm**Human data:** A 5-hour exposure to approximately 5 ppm caused severe headache, increased blood pressure, flushing of the extremities, and nausea [Watrous and Schulz 1950]
 **Revised IDLH:** 5 ppm [Unchanged]**Basis for revised IDLH:** Based on acute inhalation toxicity data in humans [Watrous and Schulz 1950], the original IDLH for 2-aminopyridine (5 ppm) is not being revised at this time. This may be a conservative value due to the lack of relevant acute toxicity data for workers exposed to concentrations above 5 ppm.References:
ACGIH [1971]. 2-Aminopyridine. In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 11.
Marhold J [1986]. Prehled Prumyslove Toxikologie, Organicke Latky. Prague, Czechoslovakia: Avicenum, p. 838 (in Czechoslovakian).
Verschueren K [1983]. Handbook of environmental data of organic chemicals. 2nd ed. New York, NY: Van Nostrand Reinhold, Co., p. 192.
Watrous RM, Schulz HN [1950]. Cyclohexylamine, p-chlornitrobenzene, 2-aminopyridine: toxic effects in industrial use. Ind Med Surg *19*(7):317-320.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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