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Carbaryl																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 63–25–2
**NIOSH REL:** 5 mg/m3 TWA
**Current OSHA PEL:** 5 mg/m3 TWA
**1989 OSHA PEL:** Same as current PEL
**1993-1994 ACGIH TLV:** 5 mg/m3 TWA
**Description of Substance:** White or gray, odorless solid.
**LEL:** . . Noncombustible Solid
**Original (SCP) IDLH:** 600 mg/m3
**Basis for original (SCP) IDLH:** Because no useful data on acute inhalation toxicity are available for carbaryl, the chosen IDLH is based on the rat oral LD50 of 89 mg/kg [Boyd and Taylor 1971 cited by NIOSH 1974]. In addition, ACGIH [1971] reported that female rats may occasionally be killed by a single oral dose of 100 mg/kg [Gaines 1969].
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA**
**Lethal dose data:**

**Species**
    **Reference**
    **Route**
    **LD50** **(mg/kg)**
    **LDLo** **(mg/kg)**
    **Adjusted LD**
    **Derived value**Rabbit G. pigDogRatRatCatMouseRat
    AAPCO 1966 Benson and Dorough 1984Buck 1979Gaines 1960Gaines 1960Gig Sanit 1967Stevens et al. 1972Weiss and Orzel 1967
    oral oraloraloraloraloraloraloral
    710 250759850500150128230
    ----- -----------------------------------
    4,970 mg/m31,750 mg/m35,313 mg/m35,950 mg/m33,500 mg/m31,050 mg/m3896 mg/m31,610 mg/m3
    497 mg/m3175 mg/m3531 mg/m3595 mg/m3350 mg/m3105 mg/m390 mg/m3161 mg/m3
 **Other animal data:** A concentration of about 75 mg/m3 produced typical poisoning in dogs within 5 hours [Carpenter et al. 1961].
 **Human data:** None relevant for use in determining the revised IDLH.
 
 **Revised IDLH:** 100 mg/m3**Basis for revised IDLH:** The revised IDLH for carbaryl is 100 mg/m3 based on acute toxicity data in animals [Carpenter et al. 1961; Gig Sanit 1967; Stevens et al. 1972].
**REFERENCES:**
1. AAPCO [1966]. Pesticide chemicals official compendium. Topeka, KS: Association of American Pesticide Control Officials, Inc., p. 192.
2. ACGIH [1971]. Carbaryl (Sevin). In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 37-38.
3. Benson WH, Dorough HW [1984]. Comparative ester hydrolysis of carbaryl and ethiofencarb in four mammalian species. Pest Biochem Physiol *21*:199-206.
4. Boyd EM, Taylor FI [1971]. Toxaphene toxicity in protein-deficient rats. Toxicol Appl Pharmacol *18*:158-167.
5. Buck WB [1979]. Clinical toxicosis induced by insecticides. Vet Med Small Anim Clin *74*:1119.
6. Carpenter CP, Weil CS, Palm PE, Woodside MW, Nair JH III, Smyth HF Jr [1961]. Mammalian toxicity of 1-naphthyl-N-methylcarbamate (Sevin insecticide). J Agri Food Chem *9*(1):30-39.
7. Gaines TB [1960]. The acute toxicity of pesticides to rats. Toxicol Appl Pharmacol *2*:88-99.
8. Gaines TB [1969]. Acute toxicity of pesticides. Toxicol Appl Pharmacol *14*:515-534.
9. Gig Sanit [1967]; *32*(4):29-33 (in Russian).
10. NIOSH [1974]. FC59500. Carbamic acid, methyl-, 1-naphthyl ester. In: The toxic substances list, 1974 ed. Rockville, MD: U.S. Department of Health, Education, and Welfare, Public Health Service, Center for Disease Control, National Institute for Occupational Safety and Health, DHEW (NIOSH) Publication No. 74-134, p. 182.
11. Stevens JT, Stitzel RE, McPhillips JJ [1972]. Effects of anticholinesterase insecticides on hepatic microsomal metabolism. J Pharmacol Exp Ther *181*:576-583.
12. Weiss LH, Orzel RA [1967]. Some comparative toxicologic and pharmacologic effects of dimethyl sulfoxide as a pesticide solvent. Toxicol Appl Pharmacol *11*:546-557.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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