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Antimony compounds (as Sb)																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 7440-36-0 (Metal)
**NIOSH REL:** 0.5 mg Sb/m3 TWA
**Current OSHA PEL:** 0.5 mg Sb/m3 TWA
**1989 OSHA PEL:** Same as current PEL
**1993-1994 ACGIH TLV:** 0.5 mg Sb/m3 TWA
**Description of substance:** Varies
**Original (SCP) IDLH:** 80 mg Sb/m3
**Basis for original (SCP) IDLH:** AIHA [1959] reported that the severity of hazard is moderate to high for both acute and chronic exposures to antimony and its compounds. Brieger et al. [1954] noted an apparent increase in heart abnormalities in workers chronically exposed to antimony trisulfide (0.6 to 5.5 mg/m3) and demonstrated heart injury in experimental animals. The chosen IDLH is based on the report by Taylor [1966] that slightly delayed gastrointestinal disorders, including abdominal pain and persistent anorexia, were noted in workers briefly exposed to air containing up to 73 mg/m3 of antimony.
**Short-term exposure guidelines:** None developed
ACUTE TOXICITY DATA
**Lethal concentration data:**
AdjustedLC50
    LCLo
    
    0.5-hr
    DerivedSpecies
    Reference
    (ppm)
    (ppm)
    Time
    LC (CF)
    ValueMouse
    Chekunova and Minkina 1987
    720 mg/m3
    -----
    ?
    ?
    ?Rat
    Izmerov et al. 1982
    720 mg/m3
    -----
    2 hr
    469 mg Sb/m3
    47 mg Sb/m3**Lethal dose data:** 
 LD50
    LDLo
    
    DerivedSpecies
    Reference
    Route
    (Mg/kg)
    (mg/kg)
    Adjusted LD
    ValueRat
    Coulston and Korte 1975
    oral
    7,500
    -----
    49,000 mg Sb/m3
    4,900 mg Sb/m3Rat
    Smyth and Carpenter 1948
    oral
    20,000
    -----
    117,600 mg Sb/m3
    11,760 mg Sb/m3Rat
    Arzamastev 1964
    oral
    1,115
    -----
    3,179 mg Sb/m3
    318 mg Sb/m3G.pig
    Arzamastev 1964
    oral
    900
    -----
    2,566 mg Sb/m3
    257 mg Sb/m3**Human data:** Antimony pentachloride (SbCl5) is considered to be the most toxic of the antimony chlorides [ACGIH 1991]. The American Conference of Governmental Industrial Hygienists (ACGIH) TLV for antimony is based on an analogy to hydrogen chloride [ACGIH 1991].
 **Revised IDLH:** 50 mg Sb/m3**Basis for revised IDLH:** The revised IDLH for antimony compounds is 50 mg Sb/m3 based on acute inhalation toxicity data in animals [Izmerov et al. 1982] and an analogy to hydrogen chloride [ACGIH 1991] which has a revised IDLH of 50 ppm (75 mg/m3).References:
ACGIH [1991]. Antimony and compounds. In: Documentation of the threshold limit values and biological exposure indices. 6th ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 73-75.
AIHA [1959]. Antimony and its compounds (excepting stibine). In: Hygienic guide series. Am Ind Hyg Assoc Q *20*:515-516.
Arzamastsev EV [1964]. Experimental substantiation of the permissible concentrations of tri- and pentavalent antimony in water bodies. Gig Sanit *29*(12):16-21 (translated).
Brieger H, Semisch CW, Stasney J, Piatek DA [1954]. Industrial antimony poisoning. Ind Med Surg *23*:521-523.
Chekunova MP, Minkina MA [1987]. Toxicity of pentachlorinated antimony in a chronic experiment. Gig Tr Prof Zabol *13*(10):25-29 (in Russian).
Coulston F, Korte F, eds. [1975]. Heavy metal toxicity, safety and hormology. In: Environmental Quality & Safety, Supplement 1. New York, NY: Georg Thieme Publishers, pp. 1-120.
Izmerov NF, Sanotsky IV, Sidorov KK [1982]. Toxicometric parameters of industrial toxic chemicals under single exposure. Moscow, Russia: Centre of International Projects, GKNT, p. 22.
Smyth HF Jr, Carpenter CP [1948]. Further experience with the range finding test in the industrial toxicology laboratory. J Ind Hyg Toxicol *30*(1):63-68.
Taylor PJ [1966]. Acute intoxication from antimony trichloride. Br J Ind Med *23*(4):318-321.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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