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Diethylamine																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 109–89–7
**NIOSH REL:** 10 ppm (30 mg/m3) TWA, 25 ppm (75 mg/m3) STEL
**Current OSHA PEL:** 25 ppm (75 mg/m3) TWA
**1989 OSHA PEL:** 10 ppm (30 mg/m3) TWA, 25 ppm (75 mg/m3) STEL
**1993-1994 ACGIH TLV:** 5 ppm (15 mg/m3) TWA, 15 ppm (45 mg/m3) STEL [skin]
**Description of Substance:** Colorless liquid with a fishy, ammonia-like odor.
**LEL:**. . 1.8% (10% LEL, 1,800 ppm)
**Original (SCP) IDLH:** 2,000 ppm
**Basis for original (SCP) IDLH:** Patty [1963] made the statement that a 4-hour exposure to 4,000 ppm killed 3 of 6 rats. However, because of the severe eye and lung irritation that occurs as a result of exposure to high concentrations of diethylamine, an IDLH of 2,000 ppm is chosen.
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50** **(ppm)**
    **LCLo** **(ppm)**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived** **value**Rat
    Hine et al. 1960
    4,000
    -----
    4 hr
    8,000 ppm (2.0)
    800 ppm
 **Lethal dose data:**
 
 **Species**
    **Reference**
    **Route**
    **LD50** **(mg/kg)**
    **LDLo** **(mg/kg)**
    **Adjusted LD**
    **Derived value**Rat Mouse
    Hine et al. 1960 Patel et al. 1985
    oral oral
    540 500
    ----- -----
    1,243 ppm 1,151 ppm
    124 ppm 115 ppm
 **Other animal data:** RD50 (mouse), 184 ppm [Nielsen and Yamagiwa 1989].
 **Human data:** It has been stated that the simple alkyl amines are generally more toxic than ammonia [ACGIH 1991]. The American Conference of Governmental Industrial Hygienists TLV for diethylamine (10 ppm TWA, 25 ppm STEL) was based on an analogy to ammonia (25 ppm TWA, 35 ppm STEL) [ACGIH 1991].
 
 **Revised IDLH:** 200 ppm **Basis for revised IDLH:** The revised IDLH for diethylamine is 200 ppm based on acute inhalation toxicity data in animals [Nielsen and Yamagiwa 1989] and an analogy to ammonia [ACGIH 1991].
**REFERENCES:**
1. ACGIH [1991]. Diethylamine. In: Documentation of the threshold limit values and biological exposure indices. 6th ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 460-461.
2. Hine CH, Kodama JK, Guzman RJ, Loquvam GS [1960]. The toxicity of allylamines. Arch Environ Health *1*:343-352.
3. Nielsen GD, Yamagiwa M [1989]. Structure-activity relationships of airway irritating aliphatic amines, receptor activation mechanisms and predicted industrial exposure limits. Chem Biol Interact *71*(2/3):228-244.
4. Patel VK, Venkatakrishna-Bhatt H, Patel NB, Jindal MN [1985]. Pharmacology of new glutarimide compounds. Biomed Biochim Acta *44*(5):795-803.
5. Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 2044.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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