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Uranium (soluble compounds, as U)																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** Varies
**NIOSH REL:** 0.05 mg/m3 TWA; NIOSH considers soluble uranium compounds to be potential occupational carcinogens as defined by the OSHA carcinogen policy [29 CFR 1990].
**Current OSHA PEL:** 0.05 mg/m3 TWA
**1989 OSHA PEL:** Same as current PEL
**1993-1994 ACGIH TLV:** 0.2 mg/m3 TWA, 0.6 mg/m3 STEL
**Description of substance:** Varies
**Original (SCP) IDLH:** 20 mg U/m3
**Basis for original (SCP) IDLH:** The chosen IDLH is based on the statement by Patty [1963] that UO2(NO3)2×6H20 of respirable particle size and dusts and mists of UF6, UO2F2, and UCl4 were generally fatal to most laboratory species when exposed daily for 1 month at 20 mg/m3 [Wilson et al. 1953]. No useful data on acute inhalation toxicity are available on which to base the IDLH.
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA:**
**Lethal dose data**:

**Species**
    **Reference**
    **Route**
    **LD50** **(mg/kg)**
    **LDLo** **(mg/kg)**
    **Adjusted LD**
    **Derived value**UO2(NO3)2×6H2O Dog
    Spector 1956
    oral
    -----
    12
    84 mg/m3
    8.4 mg/m3UO2(NO3)2×6H2O Cat
    Spector 1956
    oral
    -----
    238
    1,666 mg/m3
    167 mg/m3**Other animal data:** No grossly observable signs or symptoms were induced in mice, rats, guinea pigs, rabbits, or dogs following the first day of exposure to 20 mg/m3 of UF6 (13.5 mg U/m3), UO2F2 (15.5 mg U/m3), Ucl4 (12.5 mg U/m3), or UO2(NO3)2×H2O (9.5 mg U/m3) [Wilson et al. 1953].
 **Human data:** None relevant for use in determining the revised IDLH.
 
 **Revised IDLH:** 10 mg U/m3 **Basis for revised IDLH:** The revised IDLH for soluble uranium compounds is 10 mg U/m3 based on chronic toxicity data in animals [Wilson et al. 1953]. [Note: NIOSH recommends as part of its carcinogen policy that the "most protective" respirators be worn for soluble uranium compounds at concentrations above 0.05 mg U/m3.]**REFERENCES:**
1. Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 1167.
2. Spector WS, ed. [1956]. Handbook of toxicology. Vol. I. Acute toxicities. Philadelphia, PA: W.B. Saunders Company, p. 310.
3. Wilson HB, Stokinger HE, Sylvester GE [1953]. Acute toxicity of carnotite ore dust. AMA Arch Ind Hyg Occup Med 7:301-309.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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