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Silver (metal dust and soluble compounds, as Ag)																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 7440–22–4 (Metal)
**NIOSH REL:** 0.01 mg/m3 TWA
**Current OSHA PEL:** 0.01 mg/m3 TWA
**1989 OSHA PEL:** Same as current PEL
**1993-1994 ACGIH TLV:** Metal: 0.1 mg/m3 TWA;
Soluble compounds: 0.01 mg/m3 TWA
**Description of substance:** Varies
**Original (SCP) IDLH*:** No Evidence [*Note: “Effective” IDLH = 20 mg Ag/m3 — see discussion below.]
**Basis for original (SCP) IDLH:** The available toxicological data contain no evidence that an acute exposure by inhalation to silver metal or the soluble compounds of silver could impede escape. For this draft technical standard, therefore, respirators have been selected on the basis of the assigned protection factor afforded by each device up to 2,000  ́ the OSHA PEL of 0.01 mg Ag/m3 (i.e., 20 mg Ag/m3); only the “most protective” respirators are permitted for use in concentrations exceeding 20 mg Ag/m3.
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA:**
**Lethal dose data:**

**Species**
    **Reference**
    **Route**
    **LD50** **(mg/kg)**
    **LDLo** **(mg/kg)**
    **Adjusted LD**
    **Derived value**AgNO3 Rabbit
    Flury & Zernik 1935
    oral
    -----
    800
    3,556 mg Ag/m3
    356 mg Ag/m3AgNO3 Dog
    Flury & Zernik 1935
    oral
    -----
    20
    89 mg Ag/m3
    8.9 mg Ag/m3Ag2O
    Smyth et al. 1969
    oral
    2,820
    -----
    18,385 mg Ag/m3
    1,839 mg Ag/m3**Human data:** It has been reported that 29 mg/kg is the probable lethal dose [Arena 1970]. [Note: A dose of 29 mg/kg is equivalent to a 70-kg worker being exposed to 135 mg/m3 for 30 minutes, assuming a breathing rate of 50 liters per minute and 100% absorption.]
 
 **Revised IDLH:** 10 mg Ag/m3**Basis for revised IDLH:** No inhalation toxicity data are available on which to base an IDLH for silver (metal dust and soluble compounds). Therefore, the revised IDLH for silver (metal dust and soluble compounds) is 10 mg Ag/m3 based on acute oral toxicity data in humans [Arena 1970] and animals [Flury and Zernik 1935].**REFERENCES:**
1. Arena JM [1970]. Poisoning; toxicology, symptoms, treatments. 2nd ed. Springfield, IL: C.C. Thomas, *2*:73.
2. Flury F, Zernik F [1935]. Zusammenstellung der toxischen und letalen dosen für die gebräuchlichsten gifte und versuchstiere. Abder Hand Biol Arbeitsmethod *4*:1289-1422 (in German).
3. Smyth HF Jr, Carpenter CP, Weil CS, Pozzani UC, Striegel JA, Nycum JS [1969]. Range-finding toxicity data: list VII. Am Ind Hyg Assoc J *30*(5):470-476.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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