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Zirconium compounds (as Zr)																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 7440–67–7 (Metal)
**NIOSH REL:** 5 mg/m3 TWA, 10 mg/m3 STEL
**Current OSHA PEL:** 5 mg/m3 TWA
**1989 OSHA PEL:** 5 mg/m3 TWA, 10 mg/m3 STEL
**1993-1994 ACGIH TLV:** 5 mg/m3 TWA, 10 mg/m3 STEL
**Description of substance:** Varies
**Original (SCP) IDLH:** 500 mg Zr/m3
**Basis for original (SCP) IDLH:** The available toxicological data indicate that zirconium compounds possess a low order of toxicity. The chosen IDLH has been based on the citation by NIOSH [1976] that a 30-minute exposure to 500 mg/m3 of zirconium nitrate is the lowest concentration of this substance which has been shown to be lethal to rats [Mogilevskaya 1967].
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA:**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50**
    **LCLo**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived value**Zr(NO3)2 Rat
    Mogilevskaya 1967
    -----
    500 mg/m3
    30 min
    212 mg Zr/m3 (1.0)
    21 mg Zr/m3**Lethal dose data:**
 
 **Species**
    **Reference**
    **Route**
    **LD50** **(mg/kg)**
    **LDLo** **(mg/kg)**
    **Adjusted LD**
    **Derived value**ZrF6×2K Mouse
    Shalganova 1967
    oral
    98
    -----
    221 mg Zr/m3
    22 mg Zr/m3Zr(SO4)2 Rat
    Cochran et al. 1950
    oral
    3,500
    -----
    7,886 mg Zr/m3
    789 mg Zr/m3ZrOCl2 Mouse
    Delongeas et al. 1983
    oral
    1,227
    -----
    4,398 mg Zr/m3
    440 mg Zr/m3ZrOCl2 Rat
    Klimmer & Doll 1964
    oral
    2,950
    -----
    10,573 mg Zr/m3
    1,057 mg Zr/m3ZrCl4 Rat
    ACGIH 1986
    oral
    1,688
    -----
    4,643 mg Zr/m3
    464 mg Zr/m3ZrCl4 Mouse
    ACGIH 1986
    oral
    655
    -----
    1,801 mg Zr/m3
    180 mg Zr/m3ZrF4 Rat
    ACGIH 1986
    oral
    98
    -----
    374 mg Zr/m3
    37 mg Zr/m3**Human data:** None relevant for use in determining the revised IDLH.
 
 **Revised IDLH:** 25 mg Zr/m3**Basis for revised IDLH:** The revised IDLH for zirconium compounds is 25 mg Zr/m3 based on acute toxicity data in animals [ACGIH 1986; Mogilevskaya 1967; Shalganova 1967]. This may be a conservative value due to the lack of relevant acute inhalation toxicity data for workers.**REFERENCES:**
1. ACGIH [1986]. Zirconium. In: Documentation of the threshold limit values and biological exposure indices. 5th ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 647.
2. Cochran KW, Doull J, Mazur M, DuBois KP [1950]. Acute toxicity of zirconium, columbium, strontium, lanthanum, cesium, tantalum and yttrium. AMA Arch Ind Hyg Occup Med *1*:637-650.
3. Delongeas JL, Burnel D, Netter P, Grignon M, Mur JM, Royer RJ, Grignon G [1983]. Toxicité et pharmacocinétique de l’oxychlorure de zirconium chez la souris et chez le rat. J Pharmacol *14*(4):437-447 (in French).
4. Klimmer OR, Doll W [1964]. Zur frage der toxizität und speicherung löslicher zirkoniumverbindungen bei kurz- und langdauernder verfütterung an warmblüter. Arzneimittel-Forschung (Drug Research) *14*:1286-1290 (in German).
5. Mogilevskaya OY [1967]. Zirconium. In: Toxicology of the rare metals, ZI Izrael’son, ed. Translated from Russian by Y. Halperin, edited by E. Lieber. Washington, DC: U.S. Atomic Energy Commission and the National Science Foundation, pp. 44-52.
6. NIOSH [1976]. ZH87500. Zirconium nitrate. In: Registry of toxic effects of chemical substances, 1976 ed. Cincinnati, OH: U.S. Department of Health, Education, and Welfare, Public Health Service, Center for Disease Control, National Institute for Occupational Safety and Health, DHEW (NIOSH) Publication No. 76-191, p. 1230.
7. Shalganova IV [1967]. Hygienic features of the production of rare-metal fluorides. Gig Sanit *32*(10-12):343-347 (translated).

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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