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Methyl bromide																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 74–83–9
**NIOSH REL:** None established; NIOSH considers methyl bromide to be a potential occupational carcinogen as defined by the OSHA carcinogen policy [29 CFR 1990].
**Current OSHA PEL:** 20 ppm (80 mg/m3) CEILING [skin]
**1989 OSHA PEL:** 5 ppm (20 mg/m3) TWA [skin]
**1993-1994 ACGIH TLV:** 5 ppm (19 mg/m3) TWA [skin]
**Description of substance:** Colorless gas with a chloroform-like odor at high concentrations.
**LEL:** . . . 10% (10% LEL, 10,000 ppm)
**Original (SCP) IDLH:** 2,000 ppm
**Basis for original (SCP) IDLH:** The chosen IDLH is based on the statement by Patty [1963] that rats survived 2,600 ppm for 24 minutes [Irish et al. 1940].
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA:**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50 (ppm)**
    **LCLo (ppm)**
    **Time**
    **Adjusted 0.5-hr LC (CF)**
    **Derived value**Mouse RabbitRatRatMouseG. pig
    Alexeeff et al. 1985 Bakhishev 1973Bakhishev 1975Honma et al. 1985Izmerov et al. 1982Sayers et al. 1929
    1,200 7,3162,833302390-----
    ----- --------------------300
    1 hr 30 min30 min8 hr2 hr9 hr
    1,500 ppm (1.25) 7,316 ppm (1.0)2,833 ppm (1.0)755 ppm (2.5)624 ppm (1.6)780 ppm (2.6)
    150 ppm 732 ppm283 ppm76 ppm62 ppm78 ppm**Other animal data:** It has been reported that rats have survived an exposure to 2,600 ppm for 24 minutes [Irish et al. 1940].
 **Human data:** It has been stated that 220 ppm can be endured for several hours without serious effects [Clarke et al. 1945].
 
 **Revised IDLH:** 250 ppm **Basis for revised IDLH:** The revised IDLH for methyl bromide is 250 ppm based on acute inhalation toxicity data in humans [Clarke et al. 1945]. This may be a conservative value due to the lack of relevant acute toxicity data for workers exposed to concentrations above 220 ppm. [Note: NIOSH recommends as part of its carcinogen policy that the "most protective" respirators be worn for methyl bromide at any detectable concentration.]**REFERENCES:**
1. Alexeeff GV, Kilgore WW, Munoz P, Watt D [1985]. Determination of acute toxic effects in mice following exposure to methyl bromide. J Toxicol Environ Health *15*:109-123.
2. Bakhishev GN [1973]. Relative toxicity of aliphatic halohydrocarbons to rats. Farmakol Toksikol *8*:140-143 (in Russian).
3. Bakhishev GN [1975]. Relationship between chemical structure and toxicity for some halogenated aliphatic hydrocarbons. Fiz Akt Vesh *7*:35-36 (in Russian).
4. Clarke CA, Roworth CG, Holling HE [1945]. Methyl bromide poisoning. An account of four recent cases met with in one of H.M. ships. Brit J Ind Med *2*:17-23.
5. Honma T, Miyagawa M, Sato M, Hasegawa H [1985]. Neurotoxicity and metabolism of methyl bromide in rats. Toxicol Appl Pharmacol *81*:183-191.
6. Irish DD, Adams EM, Spencer HC, Rowe VK [1940]. The response attending exposure of laboratory animals to vapors of methyl bromide. J Ind Hyg Toxicol *22*(6):218-230.
7. Izmerov NF, Sanotsky IV, Sidorov KK [1982]. Toxicometric parameters of industrial toxic chemicals under single exposure. Moscow, Russia: Centre of International Projects, GKNT, p. 81.
8. Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 1252.
9. Sayers RR, Yant WP, Thomas BGH, Berger LB [1929]. Physiological response attending exposure to vapors of methyl bromide, methyl chloride, ethyl bromide, and ethyl chloride. Public Health Bulletin *185*:1-56.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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