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Dimethylamine																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 124–40–3
**NIOSH REL:** 10 ppm (18 mg/m3) TWA
**Current OSHA PEL:** 10 ppm (18 mg/m3) TWA
**1989 OSHA PEL:** Same as current PEL
**1993-1994 ACGIH TLV:** 5 ppm (9.2 mg/m3) TWA, 15 ppm (27.6 mg/m3) STEL
**Description of Substance:** Colorless gas with an ammonia- or fish-like odor.
**LEL:**. . 2.8% (10% LEL, 2,800 ppm)
**Original (SCP) IDLH:** 2,000 ppm
**Basis for original (SCP) IDLH:** No data on acute inhalation toxicity are available for dimethylamine. Therefore, the chosen IDLH is based on an analogy with diethylamine which has an IDLH of 2,000 ppm.
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50** **(ppm)**
    **LCLo** **(ppm)**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived** **value**Rat RatMouse
    Koch et al. 1980 Steinhagen et al. 1982Steinhagen et al. 1982
    4,700 4,5407,650
    ----- ----------
    4 hr 6 hr2 hr
    9,400 ppm (2.0) 10,442 ppm (2.3)12,240 ppm (1.6)
    940 ppm 1,044 ppm1,224 ppm
 **Lethal dose data:**
 
 **Species**
    **Reference**
    **Route**
    **LD50** **(mg/kg)**
    **LDLo** **(mg/kg)**
    **Adjusted LD**
    **Derived value**Rat MouseRabbitG. pig
    Dzhanashvili 1967 Dzhanashvili 1967Dzhanashvili 1967Dzhanashvili 1967
    oral oraloraloral
    698 316240240
    ----- ---------------
    2,613 ppm 1,183 ppm898 ppm898 ppm
    261 ppm 118 ppm90 ppm90 ppm
 **Other animal data:** RD50 (mouse), 511 ppm [Steinhagen et al. 1982]; RD50 (rat), 573 ppm [Steinhagen et al. 1982].
 **Human data:** None relevant for use in determining the revised IDLH.
 
 Revised IDLH: 500 ppm **Basis for revised IDLH:** The revised IDLH for dimethylamine is 500 ppm based on acute inhalation toxicity data in animals [Steinhagen et al. 1982].
**REFERENCES:**
1. Dzhanashvili GD [1967]. Maximum permissible concentration of dimethylamine in water bodies. Gig Sanit *32*(6):329-335 (translated).
2. Koch F, Guenter M, Kliche R, Lang R [1980]. Studies on the aerogenic intoxication of rats by means of methylamines. Wiss Z: Karl Marx University, Leipzig, Math-Naturwiss. Reihe *29*:463-474. [From ACGIH [1991]. Dimethylamine. In: Documentation of the threshold limit values and biological exposure indices. 6th ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 479-481.]
3. Steinhagen WH, Swenberg JA, Barrow CS [1982]. Acute inhalation toxicity and sensory irritation of dimethylamine. Am Ind Hyg Assoc J *43*(6):411-417.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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