Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link


Centers for Disease Control and Prevention. CDC twenty four seven. Saving Lives, Protecting People
					Search
		×
			NIOSH
			NIOSH
				All CDC
				Submit
			For a full list of topics:A-Z Index
			Advanced Search
		Advanced Search


The National Institute for Occupational Safety and Health (NIOSH)


Facebook
        Twitter
        LinkedIn
        Syndicate





Isoamyl alcohol (primary & secondary)																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 123-51-3 (primary), 528–75–4 (secondary)
**NIOSH REL:** 100 ppm (360 mg/m3) TWA, 125 ppm (450 mg/m3) STEL
**Current OSHA PEL:** 100 ppm (360 mg/m3) TWA
**1989 OSHA PEL:** 100 ppm (360 mg/m3) TWA, 125 ppm (450 mg/m3) STEL
**1993-1994 ACGIH TLV:** 100 ppm (361 mg/m3) TWA, 125 ppm (452 mg/m3) STEL
**Description of substance:** Colorless liquids with a disagreeable odor.
**LEL(primary):** 1.2% (10% LEL, 1,200 ppm)
**LEL (secondary):** Unknown
**Original (SCP) IDLH:** 10,000 ppm [LEL]
**Basis for original (SCP) IDLH:** The chosen IDLH is based on the lower explosive limit (LEL) of 12,000 ppm and the statement in Patty [1963] attributed to Smyth [1956] that rats survived 8,000 ppm.
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA:**
**Lethal dose data:**

**Species**
    **Reference**
    **Route**
    **LD50** (mg/kg)
    **LDLo** (mg/kg)
    **Adjusted LD**
    **Derived value**Rabbit Rat
    Munch 1972 Purchase 1969
    oral oral
    3,438 1,300
    ----- -----
    6,557 ppm 2,480 ppm
    656 ppm 248 ppm**Other animal data:** RD50 (mouse), 4,452 ppm [Alarie 1981].
 **Human data:** An oral dose of 24.3 grams has been lethal for adults [Gosselin et al. 1984]. [Note: An oral dose of 24.3 grams is equivalent to a worker being exposed to 4,000 ppm for 30 minutes, assuming a breathing rate of 50 liters per minute and 100% absorption.]
 
 **Revised IDLH:** 500 ppm **Basis for revised IDLH:** No inhalation toxicity data are available on which to base an IDLH for isoamyl alcohol. Therefore, the revised IDLH for isoamyl alcohol (primary & secondary) is 500 ppm based on acute oral toxicity data in humans [Gosselin et al. 1984] and animals [Munch 1972]. This may be a conservative value due to the lack of relevant acute inhalation toxicity data for workers.**REFERENCES:**
1. Alarie Y [1981]. Dose-response analysis in animal studies: prediction of human responses. Environ Health Perspect *42*:9-13.
2. Gosselin RE, Smith RP, Hodge HC [1984]. Clinical toxicology of commercial products. 5th ed. Section II. Ingredients Index. Baltimore, MD: Williams & Wilkins Company, p. 175.
3. Munch JC [1972]. Aliphatic alcohols and alkyl esters: narcotic and lethal potencies to tadpoles and to rabbits. Ind Med Surg *41*:31-33.
4. Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 1454.
5. Purchase IFH [1969]. Studies in kaffircorn malting and brewing. XXII. The acute toxicity of some fusel oils found in Bantu beer. S Afr Med J *43*:795-798.
6. Smyth HF Jr [1956]. Improved communication: hygienic standards for daily inhalation. Am Ind Hyg Assoc Q *17*(2):129-185.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
Pinterest
Twitter
YouTube
 NIOSH Homepage NIOSH A-Z
Workplace Safety & Health Topics
Publications and Products
Programs
Contact NIOSH


About CDC
					Contact Us
					800-232-4636
 Facebook Twitter Instagram LinkedIn Youtube Pinterest Snapchat
 CONTACT CDC
				Contact Us
							Call 800-232-4636
							Email Us
			ABOUT CDC
				About CDC
							Jobs
							Funding
			POLICIES
				Accessibility
							External Links
							Privacy
							Policies
							No Fear Act
							FOIA
							OIG
							Nondiscrimination
							Vulnerability Disclosure Policy
			CONNECT WITH US
				Facebook
								Twitter
								Instagram
								LinkedIn
							Youtube
								Pinterest
								Snapchat
								Email
			LANGUAGES
				Español
							繁體中文
							Tiếng Việt
							한국어
							Tagalog
							Русский
							العربية
							Kreyòl Ayisyen
							Français
							Polski
							Português
							Italiano
							Deutsch
							日本語
							فارسی
							English


U.S. Department of Health & Human Services
			Accessibility
			External Links
			Privacy
			Policies
			No Fear Act
			FOIA
			Nondiscrimination
			OIG
			Vulnerability Disclosure Policy
			USA.gov


Exit Notification/Disclaimer Policy Close
 Links with this icon  indicate that you are leaving the CDC website. The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website.
					Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website.
					You will be subject to the destination website's privacy policy when you follow the link.
					CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website. Website Disclaimers
 Cancel Continue