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o-Anisidine																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 90-04-0
**NIOSH REL:** 0.5 mg/m3 TWA [skin]; NIOSH considers o-anisidine to be a potential occupational carcinogen as defined by the OSHA carcinogen policy [29 CFR 1990].
**Current OSHA PEL:** 0.5 mg/m3 TWA [skin]
**1989 OSHA PEL:** Same as current PEL
**1993-1994 ACGIH TLV:** 0.1 ppm (0.5 mg/m3) TWA [skin]
**Description of substance:** Red or yellow, oily liquid with an amine-like odor.
**LEL:** Unknown
**Original (SCP) IDLH:** 50 mg/m3
**Basis for original (SCP) IDLH:** Because no data on acute inhalation toxicity are available for anisidine (o-, p-isomers), the chosen IDLH is based on chronic data. ACGIH [1971] reported that mice survived exposures to 10 to 30 mg/m3 for 2 hours/day, 6 days/week for 1 month; a decrease in the excitability of nerves was noted [Zaeva and Fedorova 1962]. Because mice survived 30 mg/m3, 2 hours/day, 6 days/week for 1 month, a worker should be able to escape from 50 mg/m3 without injury or irreversible health effects.
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA**
**Lethal dose data:**
Species
    Reference
    Route
    LD50(mg/kg)
    LDLo(mg/kg)
    Adjusted LD
    Derived ValueRat
    IARC 1982
    oral
    2,000
    -----
    14,000 mg/m3
    1,400 mg/m3Mouse
    IARC 1982
    oral
    1,400
    -----
    9,800 mg/m3
    980 mg/m3Rabbit
    IARC 1982
    oral
    870
    -----
    6,090 mg/m3
    609 mg/m3**Other animal data:** Mice have survived exposures to concentrations of 10 to 30 mg/m3 for 2 hours/day, 6 days/week for 1 month with only a decrease in the excitability of nerves noted [Zaeva and Fedorova 1962].
 **Human data:** None relevant for use in determining the revised IDLH.
 **Revised IDLH:** 50 mg/m3 [Unchanged]**Basis for revised IDLH:** Based on subchronic inhalation toxicity data in animals [Zaeva and Fedorova 1962], the original IDLH for o-anisidine (50 mg/m3) is not being revised at this time. [Note: NIOSH recommends as part of its carcinogen policy that the "most protective" respirators be worn for o-anisidine at concentrations above 0.5 mg/m3.]**REFERENCES:**
ACGIH [1971]. Anisidine (o-, p-isomers). In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 14.
IARC [1982]. IARC monographs on the evaluation of carcinogenic risk of chemicals to humans. Vol. 27. Lyon, France: World Health Organization, International Agency for Research on Cancer, p. 63.
Zaeva GN, Fedorova VI [1962]. Toxsikol Nov Prom Khim Vesh *4*:91 (in Russian).

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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