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Fluorotrichloromethane																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 75–69–4
**NIOSH REL:** 1,000 ppm (5,600 mg/m3) CEILING
**Current OSHA PEL:** 1,000 ppm (5,600 mg/m3) TWA
**1989 OSHA PEL:** 1,000 ppm (5,600 mg/m3) CEILING
**1993-1994 ACGIH TLV:** 1,000 ppm (5,620 mg/m3) CEILING
**Description of Substance:** Colorless to water-white, nearly odorless liquid or gas (above 75 F).
**LEL:** . . Noncombustible Liquid/Nonflammable Gas
**Original (SCP) IDLH:** 10,000 ppm
**Basis for original (SCP) IDLH:** Scheel (member of the Standards Completion Program Respirator Committee), in evaluating the work of Reinhardt et al. [1971], indicated cardiac toxicity occurred at 12,000 ppm. The chosen IDLH is based on that data.
**Existing short-term exposure guidelines:** National Research Council [NRC 1984] Emergency Exposure Guidance Levels (EEGLs):
1-hour EEGL: 1,500 ppm
24-hour EEGL: 500 ppm
**ACUTE TOXICITY DATA**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50** **(ppm)**
    **LCLo** **(ppm)**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived** **value**Rat RatRat
    Barras 1974 Lester and Greenberg 1950Scholz 1962
    ----- ----------
    26,200 100,000100,000
    4 hr 20 min2 hr
    52,400 ppm (2.0) 96,000 ppm (0.96)160,000 ppm (1.6)
    5,240 ppm 9,600 ppm16,000 ppm
 **Other animal data:** Evidence of serious arrhythmia was noted in 1 of 12 conscious dogs exposed for 5 minutes to 5,000 ppm plus intravenous epinephrine [Reinhardt et al. 1971]. However, in another study, endogenous epinephrin was not sufficient to precipitate arrythmia in dogs exposed to 5,000 to 10,000 ppm [Reinhardt et al. 1971].
 **Human data:** None relevant for use in determining the revised IDLH.
 
 **Revised IDLH:** 2,000 ppm **Basis for revised IDLH:** The revised IDLH for fluorotrichloromethane is 2,000 ppm based on acute toxicity data in animals [Reinhardt et al. 1971] and to be consistent with a closely-related chlorofluorocarbon, 1,1,2-trichloro-1,2,2-trifluoroethane which has a revised IDLH of 2,000 ppm.
**REFERENCES:**
1. Barras CE [1974]. Unpublished data. Wilmington, DE: DuPont Company, Haskell Laboratory (October 1974). [From ACGIH [1986]. Documentation of the threshold limit values for substances in workroom air. 5th ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 598.]
2. Lester D, Greenberg LA [1950]. Acute and chronic toxicity of some halogenated derivatives of methane and ethane. AMA Arch Ind Hyg Occup Med *2*:335-344.
3. Mullin LS, Azar A, Reinhardt CF, Smith PE, Fabryka EF [1972]. Halogenated hydrocarbon-induced cardiac arrhythmias associated with release of endogenous epinephrine. Am Ind Hyg Assoc J *33*(6):389-396.
4. NRC [1984]. Emergency and continuous exposure limits for selected airborne contaminants. Vol. 2. Washington, DC: National Academy Press, Committee on Toxicology, Board on Toxicology and Environmental Health Hazards, Commission on Life Sciences, National Research Council, pp. 26-33.
5. Reinhardt CF, Azar A, Maxfield ME, Smith PE, Mullin LS [1971]. Cardiac arrhythmias and aerosol “sniffing.” Arch Environ Health *22*:265-279.
6. Scholz J [1962]. New toxicological investigations on certain types of freon used as propellants. Fortschr Biol Aerosol-forsch Jahren 1957-1961. Ber Aerosol Kongr *4*:420-429. [From ACGIH [1991]. Trichlorofluoromethane. In: Documentation of the threshold limit values and biological exposure indices. 6th ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 619-623.]

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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