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Nitrogen trifluoride																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 7783–54–2
**NIOSH REL:** 10 ppm (29 mg/m3) TWA
**1989 OSHA PEL:** Same as current PEL
**Current OSHA PEL:** 10 ppm (29 mg/m3) TWA
**1993-1994 ACGIH TLV:** 10 ppm (29 mg/m3) TWA
**Description of substance:** Colorless gas with a moldy odor.
**LEL**: . Nonflammable Gas
**Original (SCP) IDLH:** 2,000 ppm
**Basis for original (SCP) IDLH:** The chosen IDLH is based on the mouse 4-hour LC50 of 2,000 ppm cited by Deichmann and Gerarde [1969]. Deichmann and Gerarde [1969] also stated that nitrogen trifluoride is a pulmonary irritant comparable in toxicity to the oxides of nitrogen.
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA:**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50** **(ppm)**
    **LCLo** **(ppm)**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived value**Mouse
    Deichmann & Gerarde 1969
    2,000
    -----
    4 hr
    4,000 ppm (2.0)
    400 ppmDog
    MacEwen & Vernot 1969
    9,600
    -----
    1 hr
    12,000 ppm (1.25)
    1,200 ppmMonkey
    MacEwen & Vernot 1969
    7,500
    -----
    1 hr
    9,375 ppm (1.25)
    938 ppmRat
    Vernot et al. 1973
    6,700
    -----
    1 hr
    8,375 ppm (1.25)
    838 ppmMouse
    Vernot et al. 1973
    7,500
    -----
    1 hr
    9,375 ppm (1.25)
    938 ppm**Human data:** None relevant for use in determining the revised IDLH.
 
 **Revised IDLH:** 1,000 ppm **Basis for revised IDLH:** The revised IDLH for nitrogen trifluoride is 1,000 ppm based on acute inhalation toxicity data in animals [MacEwen and Vernot 1969; Vernot et al. 1973].**REFERENCES:**
1. Deichmann WB, Gerarde HW [1969]. Nitrogen trifluoride. In: Toxicology of drugs and chemicals. New York, NY: Academic Press, Inc., p. 427.
2. MacEwen JD, Vernot EH [1969]. Toxic Hazards Research Unit annual technical report: 1969. Wright-Patterson Air Force Base, OH: Aerospace Medical Research Laboratory, Report AMRL-TR-69-84, pp. 1-49.
3. Vernot EH, Haun CC, MacEwen JD, Egan GF [1973]. Acute inhalation toxicology and proposed emergency exposure limits of nitrogen trifluoride. Toxicol Appl Pharmacol *26*:1-13.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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