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Arsine																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 7784-42-1
**NIOSH REL:** 0.002 mg/m3 15-minute CEILING; NIOSH considers arsine to be a potential occupational carcinogen as defined by the OSHA carcinogen policy [29 CFR 1990].
**Current OSHA PEL:** 0.05 ppm (0.2 mg/m3) TWA
**1989 OSHA PEL:** Same as current PEL
**1993-1994 ACGIH TLV:** 0.05 ppm (0.16 mg/m3) TWA
**Description of substance:** Colorless gas with a mild, garlic-like odor.
**LEL:** 5.1% (10% LEL, 5,100 ppm)
**Original (SCP) IDLH:** 6 ppm
**Basis for original (SCP) IDLH:** The chosen IDLH is based on the statement by Patty [1963] that 6 to 30 ppm is the maximum concentration that can be inhaled in 1 hour without serious consequences [Henderson and Haggard 1943]. The chosen IDLH falls within the range of 1 to 10 ppm, which AIHA [1965] suggested might be dangerous for a 1-hour exposure [Elkins 1959; Kipling and Fothergill 1964].
**Existing short-term exposure:** National Research Council [NRC 1984] guidelines Emergency Exposure Guidance Levels (EEGLs):
1-hour EEGL: 1.0 ppm
24-hour EEGL: 0.1 ppm**ACUTE TOXICITY DATA**
**Lethal concentration data:**
Species
    Reference
    LC50(ppm)
    LCLo(ppm)
    Time
    Adjusted 0.5-hr LC(CF)
    Derived ValueRat
    Gates et al. 1946
    120
    -----
    10 min
    83 ppm (0.69)
    8.3 ppmMouse
    Gates et al. 1946
    77
    -----
    10 min
    53 ppm (0.69)
    5.3 ppmRabbit
    Gates et al. 1946
    201
    -----
    10 min
    138 ppm (0.69)
    14 ppmDog
    Gates et al. 1946
    108
    -----
    10 min
    75 ppm (0.69)
    7.5 ppmHuman
    Henderson and Haggard 1943
    -----
    250
    30 min
    250 ppm (1.0)
    25ppmHuman
    Tab Biol Per 1933
    -----
    300
    5 min
    165 ppm (0.55)
    17 ppmHuman
    Teitelbaum and Kier 1969
    -----
    25
    30 min
    25 ppm (1.0)
    2.5 ppm**Other animal data:** RD50 (mouse), 13 ppm [Peterson and Bhattacharyya 1985].
 **Other human data:** It has been reported that poisoning symptoms occur after a few hours exposure to 3 to 10 ppm [Henderson and Haggard 1943]. It has been suggested that 1 to 10 ppm might be dangerous for a 1 hour exposure [AIHA 1965] and that 6 to 30 ppm is the maximum concentration that can be inhaled in 1 hour without serious consequences [Henderson and Haggard 1943]. It has been estimated that 1,543 ppm for 2 minutes and 62 ppm for 30 minutes are minimal disabling exposures [Gates et al. 1946].
 
 **Revised IDLH:** 3 ppm**Basis for revised IDLH:** The revised IDLH for arsine is 3 ppm based on acute inhalation toxicity data in humans [AIHA 1965; Henderson and Haggard 1943; Teitelbaum and Kier 1969]. [Note: NIOSH recommends as part of its carcinogen policy that the "most protective" respirators be worn for arsine at concentrations above 0.002 mg As/m3.]**REFERENCES:**
AIHA [1965]. Arsine. In: Hygienic guide series. Am Ind Hyg Assoc J *26*:438-441.
Elkins HB [1959]. Arsenic, As. In: The chemistry of industrial toxicology. 2nd ed. New York, NY: John Wiley & Sons, Inc., pp. 62-65.
Gates M, Williams J, Zapp JA [1946]. Arsenicals. In: Summary technical report of Division 9, NRDC. Vol. 1. Chemical warfare agents, and related chemical problems. Part 1. Washington, DC: Office of Scientific Research and Development, National Defense Research Committee, pp. 83-114.
Henderson Y, Haggard HW [1943]. Noxious gases. 2nd ed. New York, NY: Reinhold Publishing Corporation, p. 242.
Kipling MD, Fothergill R [1964]. Arsine poisoning in a slag-washing plant. Br J Ind Med *21*:74-77.
NRC [1984]. Emergency and continuous exposure limits for selected airborne contaminants. Vol. 1. Washington, DC: National Academy Press, Committee on Toxicology, Board on Toxicology and Environmental Health Hazards, Commission on Life Sciences, National Research Council, pp. 35-40.
Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 880.
Peterson DP, Bhattacharyya MH [1985]. Hematological responses to arsine exposure: quantitation of exposure response in mice. Fundam Appl Toxicol *5*:499-505.
Tab Biol Per [1933]; *3*:231 (in German).
Teitelbaum DT, Kier LC [1969]. Arsine poisoning: report of five cases in the petroleum industry and a discussion of the indications for exchange transfusion and hemodialysis. Arch Environ Health *19*:133-143.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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