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Cyclohexane																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 110–82–7
**NIOSH REL:** 300 ppm (1,050 mg/m3) TWA
**Current OSHA PEL:** 300 ppm (1,050 mg/m3) TWA
**1989 OSHA PEL:** Same as current PEL
**1993-1994 ACGIH TLV:** 300 ppm (1,030 mg/m3) TWA
**Description of Substance:** Colorless liquid with a sweet, chloroform-like odor.
**LEL:** . . 1.3% (10% LEL, 1,300 ppm)
**Original (SCP) IDLH:** 10,000 ppm
**Basis for original (SCP) IDLH:** The chosen IDLH is based on a statement by Patty [1963] that 12,600 ppm produced evidence of lethargy, narcosis, increased respiration rate, and convulsions in animals [Treon et al. 1943]. Also, AIHA [1963] reported that 9,300 ppm for 30 minutes resulted in restlessness, impaired coordination, and exhaustion, but no narcosis or deaths in cats, rabbits, and pigs [Flury and Zernik 1931].
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50** **(ppm)**
    **LCLo** **(ppm)**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived** **value**Mouse Rabbit
    Lazarew 1929 Treon et al. 1943
    ----- -----
    17,142 26,600
    2 hr 1 hr
    27,429 ppm (1.6) 33,250 ppm (1.25)
    2,743 ppm 3,325 ppm
 **Lethal dose data:**
 
 **Species**
    **Reference**
    **Route**
    **LD50** **(mg/kg)**
    **LDLo** **(mg/kg)**
    **Adjusted LD**
    **Derived value**Rat Mouse
    Kimura et al. 1971 NPIRI 1974
    oral oral
    12,705 813
    ----- -----
    25,410 ppm 1,626 ppm
    2,541 ppm 163 ppm
 **Human data:** None relevant for use in determining the revised IDLH.
 
 **Revised IDLH:** 1,300 ppm [LEL] **Basis for revised IDLH:** Based on health considerations and acute inhalation toxicity data in animals [Lazarew 1929; Treon et al. 1943], a value of about 3,000 ppm would have been appropriate. However, the revised IDLH for cyclohexane is 1,300 ppm based strictly on safety considerations (i.e., being 10% of the lower explosive limit of 1.3%).
**REFERENCES:**
1. AIHA [1963]. Cyclohexane. In: Hygienic guide series. Am Ind Hyg Assoc J *24*:529-531.
2. Flury F, Zernik F [1931]. Schädliche gase dämpfe, nebel, rauch- und staubarten. Berlin, Germany: Verlag von Julius Springer, p. 275 (in German).
3. Kimura ET, Ebert DM, Dodge PW [1971]. Acute toxicity and limits of solvent residue for sixteen organic solvents. Toxicol Appl Pharmacol *19*:699-704.
4. Lazarew NW [1929]. On the toxicity of various hydrocarbon vapors. Arch Exp Pathol Pharmakol *143*:223-233 (in German). [From Treon JF, Crutchfield WE Jr, Kitzmiller KV [1943]. The physiological response of animals to cyclohexane, methylcyclohexane, and certain derivatives of these compounds. II. Inhalation. J Ind Hyg Toxicol *25*(8):323-347.]
5. NPIRI [1974]. Raw materials data handbook, physical and chemical properties, fire hazard and health hazard data. Vol. 1. Organic solvents. Bethlehem, PA: National Printing Ink Research Institute, p. 17.
6. Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 1210.
7. Treon JF, Crutchfield WE Jr, Kitzmiller KV [1943]. The physiological response of animals to cyclohexane, methylcyclohexane, and certain derivatives of these compounds. II. Inhalation. J Ind Hyg Toxicol *25*(8):323-347.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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