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Diisobutyl ketone																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 108–83–8
**NIOSH REL:** 25 ppm (150 mg/m3) TWA
**Current OSHA PEL:** 50 ppm (290 mg/m3) TWA
**1989 OSHA PEL:** 25 ppm (150 mg/m3) TWA
**1993-1994 ACGIH TLV:** 25 ppm (145 mg/m3) TWA
**Description of Substance:** Colorless liquid with a mild, sweet odor.
**LEL**(@200 F): 0.8% (10% LEL(@200 F), 800 ppm)
**Original (SCP) IDLH:** 2,000 ppm
**Basis for original (SCP) IDLH:** The chosen IDLH is based on the UCC [1971] report that “breathing saturated vapors in air killed 1 of 6 animals in 8 hours; breathing 2,000 ppm for 8 hours killed 5 of 6 animals. Breathing 1,000 ppm for 8 hours produced illness but no deaths.” This is the only useful data available on which to base the IDLH for this substance.
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50** **(ppm)**
    **LCLo** **(ppm)**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived** **value**Rat Rat
    Smyth et al. 1949 Smyth et al. 1949
    ----- 2,000
    2,000 -----
    4 hr 8 hr
    4,000 ppm (2.0) 5,000 ppm (2.5)
    400 ppm 500 ppm**Lethal dose data:**
 
 **Species**
    **Reference**
    **Route**
    **LD50** **(mg/kg)**
    **LDLo** **(mg/kg)**
    **Adjusted LD**
    **Derived value**Rat MouseRat
    NPIRI 1974 Shell 1961Smyth et al. 1949
    oral oraloral
    5,750 1,4165,800
    ----- ----------
    6,799 ppm 1,674 ppm6,858 ppm
    680 ppm 167 ppm686 ppm
 **Human data:** It has been reported that a 3-hour exposure at 50 or 100 ppm caused slight irritation to the eyes, nose, and throat [Smyth et al. 1949].
 
 **Revised IDLH:** 500 ppm **Basis for revised IDLH:** The revised IDLH for diisobutyl ketone is 500 ppm based on acute inhalation toxicity data in animals [Smyth et al. 1949].
**REFERENCES:**
1. Carpenter CP, Pozzani UC, Weil CS [1953]. Toxicity and hazard of diisobutyl ketone vapors. AMA Arch Ind Hyg Occup Med *8*:377-381.
2. NPIRI [1974]. Raw materials data handbook, physical and chemical properties, fire hazard and health hazard data. Vol. 1. Organic solvents. Bethlehem, PA: National Printing Ink Research Institute, p. 23.
3. Shell [1961]. Unpublished report. Shell Chemical Company, p. 4.
4. Smyth HF Jr, Carpenter CP, Weil CS [1949]. Range-finding toxicity data: list III. J Ind Hyg Toxicol *31*:60-62.
5. UCC [1971]. Toxicology studies: diisobutyl ketone. New York, NY: Union Carbide Corporation.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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