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Ethyl silicate																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 78–10–4
**NIOSH REL:** 10 ppm (85 mg/m3) TWA
**Current OSHA PEL:** 100 ppm (850 mg/m3) TWA
**1989 OSHA PEL:** 10 ppm (85 mg/m3) TWA
**1993-1994 ACGIH TLV:** 10 ppm (85 mg/m3) TWA
**Description of Substance:** Colorless liquid with a sharp, alcohol-like odor.
**LEL:**. . Unknown
**Original (SCP) IDLH:** 1,000 ppm
**Basis for original (SCP) IDLH:** The chosen IDLH is based on the following statements by AIHA [1968]: “Smyth and Seaton [1940] reported that 1,740 ppm in dry air caused the first guinea pig death in 15 minutes, while at 1,170 ppm the first death was in 2 hours. In the presence of 70% humidity, effects were less pronounced, presumably because part of the ethyl silicate was hydrolyzed.”
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50** **(ppm)**
    **LCLo** **(ppm)**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived** **value**Rat G. pigG. pigG. pig
    Carpenter et al. 1949 Smyth and Seaton 1940Smyth and Seaton 1940Smyth and Seaton 1940
    ----- ---------------
    1,000 7001,7401,170
    4 hr 6 hr15 min2 hr
    2,000 ppm (2.0) 1,610 ppm (2.3)1,375 ppm (0.79)1,872 ppm (1.6)
    200 ppm 161 ppm138 ppm187 ppm
 **Lethal dose data:**
 
 **Species**
    **Reference**
    **Route**
    **LD50** **(mg/kg)**
    **LDLo** **(mg/kg)**
    **Adjusted LD**
    **Derived value**Rat
    Carpenter et al. 1949
    oral
    6,270
    -----
    5,068 ppm
    507 ppm
 **Other animal data:** It has been stated that 2,000 ppm is about the maximum exposure for 60 minutes without the production of serious disturbances in guinea pigs and rats; 500 ppm is the maximum exposure for several hours without causing serious effects [Smyth and Seaton 1940].
 **Human data:** Exposure to a concentration of 1,200 ppm caused lacrimation and 250 ppm caused irritation of the eyes and nose [Smyth and Seaton 1940]. It has been stated that 700 ppm is probably intolerable for more than 30 minutes [Smyth and Seaton 1940].
 
 **Revised IDLH:** 700 ppm **Basis for revised IDLH:** The revised IDLH for ethyl silicate is 700 ppm based on acute inhalation toxicity data in humans [Smyth and Seaton 1940].
**REFERENCES:**
1. AIHA [1968]. Ethyl silicate. In: Hygienic guide series. Am Ind Hyg Assoc J *29*:624-626.
2. Carpenter CP, Smyth HF Jr, Pozzani UC [1949]. The assay of acute vapor toxicity, and the grading and interpretation of results on 96 chemical compounds. J Ind Hyg Toxicol *31*:343-346.
3. Smyth HF Jr, Seaton J [1940]. Acute response of guinea pigs and rats to inhalation of the vapors of tetraethyl orthosilicate (ethyl silicate). J Ind Hyg Toxicol *22*(7):288-296.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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