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N-Ethylmorpholine																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 100–74–3
**NIOSH REL:** 5 ppm (23 mg/m3) TWA [skin]
**Current OSHA PEL:** 20 ppm (94 mg/m3) TWA [skin]
**1989 OSHA PEL:** 5 ppm (23 mg/m3) TWA [skin]
**1993-1994 ACGIH TLV:** 5 ppm (24 mg/m3) TWA [skin]
**Description of Substance:** Colorless liquid with an ammonia-like odor.
**LEL:**. . Unknown
**Original (SCP) IDLH:** 2,000 ppm
**Basis for original (SCP) IDLH:** The chosen IDLH is based on the statement that 1 of 6 rats died following a 4-hour exposure to 2,000 ppm [Smyth et al. 1954 cited by ACGIH 1971].
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50** **(ppm)**
    **LCLo** **(ppm)**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived** **value**Rat
    Smyth et al. 1954
    LC17: 2,000
    -----
    4 hr
    4,000 ppm (2.0)
    400 ppm
 **Lethal dose data:**
 
 **Species**
    **Reference**
    **Route**
    **LD50** **(mg/kg)**
    **LDLo** **(mg/kg)**
    **Adjusted LD**
    **Derived value**Rat Mouse
    Smyth et al. 1954 Timofievskaya 1979
    oral oral
    1,780 1,200
    ----- -----
    2,601 ppm 1,754 ppm
    260 ppm 175 ppm
 **Human data:** Exposures to 100 ppm for 2.5 minutes have resulted in olfactory fatigue and irritation of the eyes, nose, and throat; irritation was slight after 25 minutes at 50 ppm and absent at 25 ppm [Smyth 1964]. Corneal edema has been noted in workers exposed to concentrations greater than 40 ppm for several hours [Dernehl 1966]. In another study, workers exposed to concentrations as high as 11 ppm but averaging about 3 to 4 ppm complained of drowsiness, optical halos, and foggy vision [Woewicki 1968].
 
 **Revised IDLH:** 100 ppm **Basis for revised IDLH:** The revised IDLH for N-ethylmorpholine is 100 ppm based on acute inhalation toxicity data in humans [Dernehl 1966; Smyth 1964]. This may be a conservative value due to the lack of relevant acute toxicity data for workers exposed to concentrations above 100 ppm.
**REFERENCES:**
1. ACGIH [1971]. N-Ethylmorpholine. In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 113.
2. Dernehl CU [1966]. Health hazards associated with polyurethane foams. J Occup Med *8*:59-62.
3. Smyth JF Jr [1964]. Personal communication to ACGIH TLV Committee (November 24, 1964). [From ACGIH [1991]. N-Ethyl morpholine. In: Documentation of the threshold limit values and biological exposure indices. 6th ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 638-639.]
4. Smyth HF Jr, Carpenter CP, Weil CS, Pozzani UC [1954]. Range-finding toxicity data: list V. AMA Arch Ind Hyg Occup Med *10*:61-68.
5. Timofievskaya LA [1979]. Comparative evaluation of the toxicity of piperazine and N-methyl piperazine. Toksikol Nov Prom Khim Vesh *15*:116-123 (in Russian).
6. Woewicki A [1968]. Personal communication to ACGIH TLV Committee. [From ACGIH [1991]. N-Ethyl morpholine. In: Documentation of the threshold limit values and biological exposure indices. 6th ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 638-639.]

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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