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Phosdrin																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 7786–34–7
**NIOSH REL:** 0.01 ppm (0.1 mg/m3) TWA, 0.03 ppm (0.3 mg/m3) STEL [skin]
**Current OSHA PEL:** 0.1 mg/m3 TWA [skin]
**1989 OSHA PEL:** 0.01 ppm (0.1 mg/m3) TWA, 0.03 ppm (0.3 mg/m3) STEL [skin]
**1993-1994 ACGIH TLV:** 0.01 ppm (0.92 mg/m3) TWA,
0.03 ppm (0.27 mg/m3) STEL [skin]
**Description of substance:** Pale-yellow to orange liquid with a weak odor.
**LEL:** . . Unknown
**Original (SCP) IDLH:** 4 ppm
**Basis for original (SCP) IDLH:** No useful data on acute inhalation toxicity are available on which to base the IDLH for Phosdrin. The chosen IDLH has been estimated from the male rat oral LD50 of 6 to 7 mg/kg [Shell 1956 cited by ACGIH 1971]. [Note: A concentration of 4 ppm phosdrin is equivalent to about 40 mg/m3.]
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA:**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50 (ppm)**
    **LCLo (ppm)**
    **Time**
    **Adjusted 0.5-hr LC (CF)**
    **Derived value**Rat
    Kodama et al. 1954
    14
    -----
    1 hr
    18 ppm (1.25)
    1.8 ppm**Lethal dose data:**
 
 **Species**
    **Reference**
    **Route**
    **LD50 (mg/kg)**
    **LDLo (mg/kg)**
    **Adjusted LD**
    **Derived value**Rat MouseRat
    Kenaga 1979 Kodama et al. 1954Shell 1956
    oral oraloral
    3 46-7
    ----- ----------
    2.3 ppm 3.0 ppm4.5-5.3 ppm
    0.2 ppm 0.3 ppm0.5 ppm**Human data:** A dose of 2.5 mg/day for 27 days caused a 25% decrease in red blood cell cholinesterase [Rider et al. 1975]. [Note: An oral dose of 2.5 mg/day for 27 days is equivalent to a worker being exposed to about 5 ppm for 30 minutes, assuming a breathing rate of 50 liters per minute and 100% absorption.]
 
 **Revised IDLH:** 4 ppm [Unchanged] **Basis for revised IDLH:** Based on acute toxicity data in humans [Rider et al. 1975], the original IDLH for phosdrin (4 ppm) is not being revised at this time.**REFERENCES:**
1. ACGIH [1971]. Phosdrin (mevinphos). In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 208.
2. Kenaga EE [1979]. Acute and chronic toxicity of 75 pesticides to various animal species. Down to Earth *35*:25-31.
3. Kodama J, Morse MS, Anderson HH, Dunlap MK, Hines CH [1954]. Comparative toxicity of two vinyl-substituted phosphates. AMA Arch Ind Hyg Occup Med *9*:45-61.
4. Rider JA, Puletti EJ, Swader JI [1975]. The minimal oral toxicity level for mevinphos in man. Toxicol Appl Pharmacol *32*(10):97-100.
5. Shell [1956]. Personal communication to ACGIH from the Shell Chemical Corporation, August 31, 1956. [From ACGIH [1991]. Phosdrin. In: Documentation of the threshold limit values and biological exposure indices. 6th ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 1044-1046.]

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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