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2-Ethoxyethanol																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 110–80–5
**NIOSH REL:** 0.5 ppm (1.8 mg/m3) TWA [skin]
**Current OSHA PEL:** 200 ppm (740 mg/m3) TWA [skin]
**1989 OSHA PEL:** Same as current PEL
**1993-1994 ACGIH TLV:** 5 ppm (18 mg/m3) TWA [skin]
**Description of Substance:** Colorless liquid with a sweet, pleasant, ether-like odor.
**LEL**(@200 F): 1.7% (10% LEL(@200 F), 1,700 ppm)
**Original (SCP) IDLH:** 6,000 ppm
**Basis for original (SCP) IDLH:** The chosen IDLH is based on the statement by AIHA [1963] that investigators concluded from animal experiments that substantially saturated atmospheres (6,000 ppm) at ordinary room temperatures will not produce serious injury in 1 hour [Waite et al. 1930].
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50** **(ppm)**
    **LCLo** **(ppm)**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived** **value**Rat G. pigMouse
    NPIRI 1974 Waite et al. 1930Werner et al. 1943
    2,000 -----1,820
    ----- 3,000-----
    7 hr 24 hr7 hr
    4,800 ppm (2.4) 10,950 ppm (3.65)4,368 ppm (2.4)
    480 ppm 1,095 ppm437 ppm
 **Lethal dose data:**
 
 **Species**
    **Reference**
    **Route**
    **LD50** **(mg/kg)**
    **LDLo** **(mg/kg)**
    **Adjusted LD**
    **Derived value**Mouse Rat
    Eastman 1982 Gig Tr Prof Zabol 1963
    oral oral
    2,451 2,125
    ----- -----
    4,575 ppm 3,967 ppm
    458 ppm 397 ppm
 **Other animal data:** Some investigators have stated that at ordinary room temperatures substantially saturated atmospheres (i.e., about 6,000 ppm) will not produce serious injury in 1 hour [Waite et al. 1930].
 **Human data:** Volunteers with some work experience reported that odor levels of 125 ppm were noticeable and that the odor level that would be intolerable was greater than 255 ppm [Clayton and Clayton 1982].
 
 **Revised IDLH:** 500 ppm **Basis for revised IDLH:** The revised IDLH for 2-ethoxyethanol is 500 ppm based on acute inhalation toxicity data in animals [NPIRI 1974; Werner et al. 1943]. This may be a conservative value due to the lack of relevant acute toxicity data for workers exposed to concentrations above 255 ppm.
**REFERENCES:**
1. AIHA [1963]. Ethylene glycol monoethyl ether (2-ethoxyethanol). In: Hygienic guide series. Am Ind Hyg Assoc J *24*:288-289.
2. Clayton GD, Clayton FE, eds. [1982]. Patty’s industrial hygiene and toxicology. 3rd rev. ed. Vol. 2C. Toxicology. New York: John Wiley & Sons, Inc., p. 3926.
3. Eastman Chemical Products [1982]. Material safety data sheet: EKTASOLVE® EE solvent. Kingsport, TN: Eastman Chemical Products, Inc., MSDS-10, 170A-1 (10-82), pp. 1-7.
4. Gig Tr Prof Zabol [1963]; *32*(3):48-54 (in Russian).
5. NPIRI [1974]. Raw materials data handbook, physical and chemical properties, fire hazard and health hazard data. Vol. 1. Organic solvents. Bethlehem, PA: National Printing Ink Research Institute, p. 54.
6. Waite CP, Patty FA, Yant WP [1930]. Acute response of guinea pigs to vapors of some new commercial organic compounds. III. “Cellosolve” (mono-ethyl ether of ethylene glycol). Public Health Rep *45*:1459-1466.
7. Werner HW, Mitchell JL, Miller JW, von Oettingen WF [1943]. Acute toxicity of vapors of several monoalkyl ethers of ethylene glycol. J Ind Hyg Toxicol *25*:157-163.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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