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N,N-Dimethylaniline																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 121–69–7
**NIOSH REL:** 5 ppm (25 mg/m3) TWA, 10 ppm (50 mg/m3) STEL [skin]
**Current OSHA PEL:** 5 ppm (25 mg/m3) TWA [skin]
**1989 OSHA PEL:** 5 ppm (25 mg/m3) TWA, 10 ppm (50 mg/m3) STEL [skin]
**1993-1994 ACGIH TLV:** 5 ppm (25 mg/m3) TWA, 10 ppm (50 mg/m3) STEL [skin]
**Description of Substance:** Pale yellow, oily liquid with an amine-like odor.
**LEL:**. . Unknown
**Original (SCP) IDLH:** 100 ppm
**Basis for original (SCP) IDLH:** No quantitative data on acute inhalation toxicity are available for dimethylaniline. Because the TLV for dimethylaniline is based on an analogy with aniline [ACGIH 1971], the chosen IDLH is also based on an analogy with aniline, which has an IDLH of 100 ppm.
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50** **(ppm)**
    **LCLo** **(ppm)**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived** **value**Rat
    Slusar et al. 1972
    -----
    50
    4 hr
    100 ppm (2.0)
    10 ppm**Lethal dose data:**
 
 **Species**
    **Reference**
    **Route**
    **LD50** **(mg/kg)**
    **LDLo** **(mg/kg)**
    **Adjusted LD**
    **Derived value**Rat
    Smyth et al. 1962
    oral
    1,410
    -----
    1,958 ppm
    196 ppm
 **Human data:** N,N-Dimethylaniline has been reported to be quantitatively less toxic than aniline but produces a very similar effect -- notably, methemoglobinemia [Clayton and Clayton 1981]. It has been reported that 50 mg/kg is the lethal oral dose [Hall 1969]. [Note: An oral dose of 50 mg/kg is equivalent to a 70-kg worker being exposed to 2,333 mg/m3 (463 ppm) for 30 minutes, assuming a breathing rate of 50 liters per minute and 100% absorption.]
 
 **Revised IDLH:** 100 ppm [Unchanged] **Basis for revised IDLH:** Based on an analogy with aniline [Clayton and Clayton 1981] which has an IDLH of 100 ppm and to acute oral toxicity data in humans [Hall 1969], the original IDLH for N,N-dimethylaniline (100 ppm) is not being revised for at this time.
**REFERENCES:**
1. ACGIH [1971]. Dimethylaniline (n-dimethylaniline). In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 89.
2. Clayton GD, Clayton FE, eds. [1981]. Patty’s industrial hygiene and toxicology. 3rd rev. ed. Vol. 2A. Toxicology. New York: John Wiley & Sons, Inc., pp. 2416-2454.
3. Hall R [1969]. Adhesives. Washington DC: National Clearinghouse for Poison Control Centers Bulletin, p. 5. Jan/Feb, 1969.
4. Slusar MP, Zvezday VI, Kolodub FA [1972]. Hygienic standardization of N,N-dimethylaniline in the air of industrial premises. Gig Sanit *37*(4):35-37 (in Russian).
5. Smyth HF, Carpenter CP, Weil CS, Pozzani UC, Striegel JA [1962]. Range-finding toxicity data: list VI. Am Ind Hyg Assoc J *23*:95-107.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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