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Acetic anhydride																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 108-24-7
**NIOSH REL:** 5 ppm (20 mg/m3) CEILING
**Current OSHA PEL:** 5 ppm (20 mg/m3) TWA
**1989 OSHA PEL:** 5 ppm (20 mg/m3) CEILING
**1993-1994 ACGIH TLV:** 5 ppm (21 mg/m3) TWA
**Description of substance:** Colorless liquid with a strong, pungent, vinegar-like odor.
**LEL:** 2.7% (10% LEL, 2,700 ppm)
**Original (SCP) IDLH:** 1,000 ppm
**Basis for original (SCP) IDLH:** According to AIHA [1971], all rats exposed for 4 hours to 2,000 ppm were dead within 14 days while all rats exposed for 4 hours to 1,000 ppm survived the 14-day observation period [Capellini and Sartorelli 1967]. Because 2,000 ppm is obviously too high to be selected as the IDLH, 1,000 ppm has been chosen.
**Short-term exposure guidelines:** None developed
ACUTE TOXICITY DATA
**Lethal concentration data:**
AdjustedLC50
    LCLo
    
    0.5-hr
    DerivedSpecies
    Reference
    (ppm)
    (ppm)
    Time
    LC (CF)
    ValueRat
    Deichmann and
    1,000
    -----
    4 hr
    2,000 ppm (2.0)
    200 ppm**Human data:** None relevant for use in determining the revised IDLH.
 **Revised IDLH:** 200 ppm**Basis for revised IDLH:** The revised IDLH for acetic anhydride is 200 ppm based on acute inhalation toxicity data in animals [Deichmann and Gerarde 1969]. This may be a conservative value due to the lack of relevant acute toxicity data for workers.References:
AIHA [1972]. Acetic anhydride. In: Hygienic guide series. Am Ind Hyg Assoc J *32*(1):64-67.
Capellini A, Sartorelli [1967]. Episodio di intossicazione collettiva da anidride acetica ed acido acetico. Med Lav *58*:108-112 (in Italian).
Deichmann WB, Gerarde HW [1969]. Trifluoroacetic acid (3FA). In: Toxicology of drugs and chemicals. New York, NY: Academic Press, Inc., p. 607.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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