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Methyl acetate																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 79–20–9
**NIOSH REL:** 200 ppm (610 mg/m3) TWA, 250 ppm (760 mg/m3) STEL
**Current OSHA PEL:** 200 ppm (610 mg/m3) TWA
**1989 OSHA PEL:** 200 ppm (610 mg/m3) TWA, 250 ppm (760 mg/m3) STEL
**1993-1994 ACGIH TLV:** 200 ppm (606 mg/m3) TWA, 250 ppm (757 mg/m3) STEL
**Description of substance:** Colorless liquid with a fragrant, fruity odor.
**LEL**:. . 3.1% (10% LEL, 3,100 ppm)
**Original (SCP) IDLH:** 10,000 ppm
**Basis for original (SCP) IDLH:** The chosen IDLH is based on an analogy with butyl acetate and ethyl acetate which have IDLHs of 10,000 ppm.
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA:**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50 (ppm)**
    **LCLo (ppm)**
    **Time**
    **Adjusted 0.5-hr LC (CF)**
    **Derived value**Mouse CatRat
    Flury and Wirth 1933 Flury and Wirth 1933Smyth et al. 1962
    ----- ----------
    11,039 21,75332,000
    4 hr 1 hr4 hr
    22,078 ppm (2.0) 27,191 ppm (1.25)64,000 ppm (2.0)
    2,208 ppm 2,719 ppm6,400 ppm**Lethal dose data:**
 
 **Species**
    **Reference**
    **Route**
    **LD50 (mg/kg)**
    **LDLo (mg/kg)**
    **Adjusted LD**
    **Derived value**Rabbit
    Munch 1972
    oral
    3,700
    -----
    8,409 ppm
    841 ppm**Human data:** It has been reported that concentrations of 10,000 ppm for a short time caused irritation which persisted after exposure stopped [Clayton and Clayton 1981].
 
 **Revised IDLH:** 3,100 ppm [LEL] **Basis for revised IDLH:** Based on health considerations and acute inhalation toxicity data in humans [Clayton and Clayton 1981], the original value of about 10,000 ppm would have been appropriate for methyl acetate. However, the revised IDLH for methyl acetate is 3,100 ppm based strictly on safety considerations (i.e., being 10% of the lower explosive limit of 3.1%).**REFERENCES:**
1. Clayton GD, Clayton FE, eds. [1981]. Patty’s industrial hygiene and toxicology. 3rd rev. ed. Vol. 2A. Toxicology. New York, NY: John Wiley & Sons, Inc., p. 2272.
2. Flury F, Wirth W [1933]. Zur toxikologie der lösungsmittel (Verschieden ester, aceton, methylalkohol). Arch Gewerbepath Gewerbehyg *5*:1-90 (in German).
3. Munch JC [1972]. Aliphatic alcohols and alkyl esters: narcotic and lethal potencies to tadpoles and to rabbits. Ind Med Surg *41*:31-33.
4. Smyth HF Jr, Carpenter CP, Weil CS, Pozzani UC, Striegel JA [1962]. Range-finding toxicity data: list VI. Am Ind Hyg Assoc J *23*:95-107.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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