Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link


Centers for Disease Control and Prevention. CDC twenty four seven. Saving Lives, Protecting People
					Search
		×
			NIOSH
			NIOSH
				All CDC
				Submit
			For a full list of topics:A-Z Index
			Advanced Search
		Advanced Search


The National Institute for Occupational Safety and Health (NIOSH)


Facebook
        Twitter
        LinkedIn
        Syndicate





Chlordane																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 57–74–9
**NIOSH REL:** 0.5 mg/m3 TWA [skin]; NIOSH considers chlordane to be a potential occupational carcinogen as defined by the OSHA carcinogen policy [29 CFR 1990].
**Current OSHA PEL:** 0.5 mg/m3 TWA [skin]
**1989 OSHA PEL:** Same as current PEL
**1993-1994 ACGIH TLV:** 0.5 mg/m3 TWA [skin]
**Description of Substance:** Amber-colored, viscous liquid with a pungent, chlorine-like odor.
**LEL:** . . Noncombustible Liquid
**Original (SCP) IDLH:** 500 mg/m3
**Basis for original (SCP) IDLH:** No useful data on acute inhalation toxicity are available on which to base the IDLH for chlordane. For this draft technical standard, therefore, the chosen IDLH has been estimated from the fatal oral dose to an adult of 6 to 60 grams reported by the Pennsylvania Department of Environmental Resources [1969].
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA**
**Lethal dose data:**

**Species**
    **Reference**
    **Route**
    **LD50** **(mg/kg)**
    **LDLo** **(mg/kg)**
    **Adjusted LD**
    **Derived value**Rabbit RatMouseRabbitMouseHamsterRat
    AAPCO 1966 Ambrose et al. 1953Ambrose et al. 1953Ambrose et al. 1953PCRB 1966Truhaut et al. 1974von Schwabe and Wendling1967
    oral oraloraloraloraloraloral
    100 5904303001451,720200
    ----- ------------------------------
    700 mg/m34,130 mg/m33,010 mg/m32,100 mg/m31,015 mg/m312,040 mg/m31,400 mg/m3
    70 mg/m3413 mg/m3301 mg/m3210 mg/m3102 mg/m31,204 mg/m3140 mg/m3
 **Human data:** The fatal oral dose has been estimated to be about 6 grams [Derbes et al. 1955] or to range from 6 to 60 grams [Pennsylvania 1969]. [Note: An oral dose of 6 grams is equivalent to a worker being exposed to about 4,000 mg/m3 for 30 minutes, assuming a breathing rate of 50 liters per minute and 100% absorption.]
 
 **Revised IDLH:** 100 mg/m3**Basis for revised IDLH:** No inhalation toxicity data are available on which to base an IDLH for chlordane. Therefore, the revised IDLH for chlordane is 100 mg/m3 based on acute oral toxicity data in humans [Derbes et al. 1955; Pennsylvania 1969] and animals [AAPCO 1966; PCRB 1966; von Schwabe and Wendling 1967]. [Note: NIOSH recommends as part of its carcinogen policy that the "most protective" respirators be worn for chlordane at concentrations above 0.5 mg/m3.]
**REFERENCES:**
1. AAPCO [1966]. Pesticide chemicals official compendium. Topeka, KS: Association of American Pesticide Control Officials, Inc., p. 226.
2. Ambrose AM, Christensen HE, Robbins DJ, Rather LJ [1953]. Toxicological and pharmacological studies on chlordane. AMA Arch Ind Hyg Occup Med *7*:197-210.
3. Derbes VJ, Dent JH, Forrest WW, Johnson MF [1955]. Fatal chlordane poisoning. JAMA *158*:1367-1369.
4. PCRB [1966]. Informative memo no. 20. Beltsville, MD: U.S. Department of Agriculture, Agricultural Research Service, Entomology Research Division, Pesticide Chemicals Research Branch, p. 19.
5. Pennsylvania Department of Environmental Resources [1969]. Hygienic information guide no. 70: chlordane. Harrisburg, PA: Commonwealth of Pennsylvania, Occupational Health H722.115P Rev. 1-69.
6. Truhaut R, Gak J-C, Graillot C [1974]. Recherches sur les modalités et les mécanismes d’action toxique des insecticides organochlorés. I. Étude comparative des effets de toxicité aiguë chez le hamster et chez le rat. J Eur Toxicol Hyg *7*:159-166 (in French).
7. von Schwabe U, Wendling I [1967]. Beschleunigung des arzneimittel-abbaus durch kleine dosen von DDT und anderen chlorkoblenwasserstoff-insekticiden. Arzneimittel-Forschung (Drug Research) *17*:614-618 (in German).

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
Pinterest
Twitter
YouTube
 NIOSH Homepage NIOSH A-Z
Workplace Safety & Health Topics
Publications and Products
Programs
Contact NIOSH


About CDC
					Contact Us
					800-232-4636
 Facebook Twitter Instagram LinkedIn Youtube Pinterest Snapchat
 CONTACT CDC
				Contact Us
							Call 800-232-4636
							Email Us
			ABOUT CDC
				About CDC
							Jobs
							Funding
			POLICIES
				Accessibility
							External Links
							Privacy
							Policies
							No Fear Act
							FOIA
							OIG
							Nondiscrimination
							Vulnerability Disclosure Policy
			CONNECT WITH US
				Facebook
								Twitter
								Instagram
								LinkedIn
							Youtube
								Pinterest
								Snapchat
								Email
			LANGUAGES
				Español
							繁體中文
							Tiếng Việt
							한국어
							Tagalog
							Русский
							العربية
							Kreyòl Ayisyen
							Français
							Polski
							Português
							Italiano
							Deutsch
							日本語
							فارسی
							English


U.S. Department of Health & Human Services
			Accessibility
			External Links
			Privacy
			Policies
			No Fear Act
			FOIA
			Nondiscrimination
			OIG
			Vulnerability Disclosure Policy
			USA.gov


Exit Notification/Disclaimer Policy Close
 Links with this icon  indicate that you are leaving the CDC website. The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website.
					Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website.
					You will be subject to the destination website's privacy policy when you follow the link.
					CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website. Website Disclaimers
 Cancel Continue