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1,1-Dichloro-1-nitroethane																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 594–72–9
**NIOSH REL:** 2 ppm (10 mg/m3) TWA
**Current OSHA PEL:** 10 ppm (60 mg/m3) CEILING
**1989 OSHA PEL:** 2 ppm (10 mg/m3) TWA
**1993-1994 ACGIH TLV:** 2 ppm (12 mg/m3) TWA
**Description of Substance:** Colorless liquid with an unpleasant odor.
**LEL:**. . Unknown
**Original (SCP) IDLH:** 150 ppm
**Basis for original (SCP) IDLH:** The chosen IDLH is based on the study by Machle et al. [1945] in which autopsies on animals exposed to over 170 ppm for over 30 minutes revealed pulmonary edema and hemorrhage, with damage to the heart, liver, and kidneys.
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50** **(ppm)**
    **LCLo** **(ppm)**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived** **value**Rabbit G. pigRabbitG. pigRabbitG. pig
    Machle et al. 1945 Machle et al. 1945Machle et al. 1945Machle et al. 1945Machle et al. 1945Machle et al. 1945
    170 17097975252
    ----- -------------------------
    30 min 30 min6 hr6 hr18.75 hr18.75 hr
    170 ppm (1.0) 170 ppm (1.0)223 ppm (2.3)223 ppm (2.3)172 ppm (3.33)172 ppm (3.33)
    17 ppm 17 ppm22 ppm22 ppm17 ppm17 ppm
 **Other animal data:** Animals have tolerated 25 ppm for 204 hours [ Machle et al. 1945].
 **Human data:** None relevant for use in determining the revised IDLH.
 
 **Revised IDLH:** 25 ppm **Basis for revised IDLH:** The revised IDLH for 1,1-dichloro-1-nitroethane is 25 ppm based on acute inhalation toxicity data in animals [Machle et al. 1945]. This may be a conservative value due to the lack of relevant acute toxicity data for workers.
**REFERENCE:**
1. Machle W, Scott EW, Treon JF, Heyroth FF, Kitzmiller KV [1945]. The physiological response of animals to certain chlorinated mononitroparaffins. J Ind Hyg Toxicol *27*(4):95-102.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
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