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Zinc oxide																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 1314–13–2
**NIOSH REL:** Fume: 5 mg/m3 TWA, 10 mg/m3 STEL;
Dust: 5 mg/m3 TWA, 15 mg/m3 CEILING
**Current OSHA PEL:** Fume: 5 mg/m3 TWA;
Dust: 15 mg/m3 (total dust) TWA,
5 mg/m3 (respirable dust) TWA
**1989 OSHA PEL:** Fume: 5 mg/m3 TWA, 10 mg/m3 STEL;
Dust: 10 mg/m3 (total dust) TWA,
5 mg/m3 (respirable dust) TWA
**1993-1994 ACGIH TLV:** Fume: 5 mg/m3 TWA, 10 mg/m3 STEL;
Dust: 10 mg/m3 TWA
**Description of substance:** White, odorless solid.
**LEL:** . . Noncombustible Solid
**Original (SCP) IDLH*:** No Evidence* [*Note: “Effective” IDLH = 2,500 mg/m3) — see discussion below.]
**Basis for original (SCP) IDLH:** The available toxicological data contains no evidence that an acute exposure to a high concentration of zinc oxide fume would impede escape within 30 minutes or cause any irreversible health effects. For this draft technical standard, therefore, respirators have been selected on the basis of the assigned protection factor afforded by each device. However, for some particulate substances for which no evidence of an IDLH exists, the determination of allowable respiratory protection based on protection factors may result in the assignment of respirators for concentrations that are not likely to be encountered in the occupational environment. Therefore, for all such particulate substances it has been arbitrarily determined that only the “most protective” respirators are permitted for use in concentrations exceeding 500  ́ the OSHA PEL of 5 mg/m3 (i.e., 2,500 mg/m3).
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA:**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50**
    **LCLo**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived value**Mouse
    Takahashi 1976
    2,500 mg/m3
    -----
    ?
    ?
    ?G. pig
    Turner & Thompson 1926
    -----
    2,500 mg/m3
    3-4 hr
    4,500-5,000 mg/m3 (1.8/2.0)
    450-500 mg/m3**Lethal dose data:**
 
 **Species**
    **Reference**
    **Route**
    **LD50** **(mg/kg)**
    **LDLo** **(mg/kg)**
    **Adjusted LD**
    **Derived value**Mouse
    Gig Sanit 1986
    oral
    7,950
    -----
    55,650 mg/m3
    5,565 mg/m3**Human data:** Workers exposed to zinc concentrations between 320 to 580 mg/m3 for 1-3 hours have experienced nausea on the job, and chills, shortness of breath, and severe chest pains 2 to 12 hours later [Hammond 1944]. Two men exposed to about 600 mg/m3 for 10.5 to 12 minutes experienced headaches, chills, and fever with cough and a decrease in vital capacity which persisted for 15 hours after exposure [Sturgis and Thompson 1927]. When air concentrations approach 600 mg/m3, it has been reported that visibility is occluded [Turner and Thompson 1926]. The lethal oral dose has been reported to be 500 mg/kg [Gekkan Yakuji 1980]. [Note: An oral dose of 500 mg/kg is equivalent to a 70-kg worker being
 exposed to about 23,300 mg/m3 for 30 minutes, assuming a breathing rate of 50 liters per minute and 100% absorption.]
 
 **Revised IDLH:** 500 mg/m3**Basis for revised IDLH:** The revised IDLH for zinc oxide is 500 mg/m3 based on acute inhalation toxicity data in humans [Hammond 1944; Sturgis and Thompson 1927].**REFERENCES:**
1. Gekkan Yakuji (Pharmaceuticals Monthly) [1980]; *22*:291-298 (in Japanese).
2. Gig Sanit [1986]; *51*(4):89-90 (in Russian).
3. Hammond JW [1944]. Metal fume fever in the crushed stone industry. J Ind Hyg Toxicol *26*(4):117-119.
4. Sturgis CC, Thompson PD [1927]. Metal fume fever: I. Clinical observations on the effect of the experimental inhalation of zinc oxide by two apparently normal persons. J Ind Hyg *9*(3):88-97.
5. Takahashi A [1976]. Problems of hygiene maintenance for food coming into contact with rubber and plastics products. Int Polymer Sci Tech *3*(1):93-105.
6. Turner JA, Thompson LR [1926]. Health hazards of brass foundries. Section II. Laboratory studies relating to pathology of brass foundrymen’s ague. Public Health Bulletin *157*:35-75.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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