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Tributyl phosphate																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 126–73–8
**NIOSH REL:** 0.2 ppm (2.5 mg/m3) TWA
**Current OSHA PEL:** 5 mg/m3 TWA
**1989 OSHA PEL:** 0.2 ppm (2.5 mg/m3) TWA
**1993-1994 ACGIH TLV:** 0.2 ppm (2.2 mg/m3) TWA
**Description of substance:** Colorless to pale-yellow, odorless liquid.
**LEL:** . . Unknown
**Original (SCP) IDLH:** 125 ppm
**Basis for original (SCP) IDLH:** The chosen IDLH is based on the only available data on acute inhalation toxicity of exposure to tributyl phosphate. Patty [1963] reported that 0 of 3 rats succumbed to a 6-hour exposure to 123 ppm (1,337 mg/m3) [Fassett]. No other quantitative data are available on which to base the IDLH.
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA:**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50** **(ppm)**
    **LCLo** **(ppm)**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived value**Cat
    Eller 1937
    -----
    2,214
    5 hr
    4,760 ppm (2.15)
    476 ppmCat
    IPCS 1991
    227
    -----
    4-5 hr
    454-488 ppm (2.0/2.15)
    45-49 ppmRat
    IPCS 1991
    123
    -----
    6 hr
    283 ppm (2.3)
    28 ppmRat
    Kalinina 1971
    117
    -----
    ?
    ?
    ?Rat
    TSCATS
    2,529
    -----
    1 hr
    3,161 ppm (1.25)
    316 ppm**Lethal dose data:**
 
 **Species**
    **Reference**
    **Route**
    **LD50** **(mg/kg)**
    **LDLo** **(mg/kg)**
    **Adjusted LD**
    **Derived value**Mouse
    Kalinina 1971
    oral
    1,189
    -----
    752 ppm
    75 ppmRat
    Smyth & Carpenter 1944
    oral
    3,000
    -----
    1,897 ppm
    190 ppm**Other animal data:** It has been reported that rats survived a 6-hour exposure to 123 ppm (1,337 mg/m3) [Patty 1963].
 **Human data:** Nausea and headache have been reported in workers exposed to 15 mg/m3 (1.4 ppm) [Mastromatteo 1964].
 
 **Revised IDLH:** 30 ppm **Basis for revised IDLH:** The revised IDLH for tributyl phosphate is 30 ppm based on acute inhalation toxicity data in animals [IPCS 1991]. This may be a conservative value due to the lack of relevant acute toxicity data in humans exposed to concentrations above 1.4 ppm.**REFERENCES:**
1. ACGIH [1991]. Tributyl phosphate. In: Documentation of the threshold limit values and biological exposure indices. 6th ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 1600-1601.
2. Eller H [1937]. Beitrag zur toxikologie technischer weichmachungsmittel (dissertation). Pharmakologishen Institut der Universitat Wursburg, Germany.
3. Fassett DW [?]. Unpublished data from the Laboratory of Industrial Medicine, Eastman Kodak Company, Rochester, NY. [From Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 1915.]
4. IPCS [1991]. Environmental health criteria 112, tri-n-butyl phosphate. Geneva, Switzerland: World health Organization, International Programme on Chemical Safety. [From ACGIH [1991]. Tributyl phosphate. In: Documentation of the threshold limit values and biological exposure indices. 6th ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 1600-1601.]
5. Kalinina NI [1971]. Toxicity of phosphoroorganic platificators tributyl phosphate and di(2-ethylhexyl)phenyl phosphate. Gig Tr Prof Zabol *15*(8):30-33 (in Russian).
6. Mastromatteo E [1964]. Personal communication to TLV Committee. [From ACGIH [1991]. Tributyl phosphate. In: Documentation of the threshold limit values and biological exposure indices. 6th ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 1600-1601.]
7. Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 1915.
8. Smyth HF Jr, Carpenter CP [1944]. The place of the range-finding test in the industrial toxicology laboratory. J Ind Hyg Toxicol *26*:269-273.
9. TSCATS. Office of Toxic Substances Report FYI-OTS-0285-0380.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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