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n-Propyl nitrate																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
CAS number 627-13-4
NIOSH REL 25 ppm (105 mg/m3) TWA, 40 ppm (170 mg/m3) STEL
Current OSHA PEL 25 ppm (110 mg/m3) TWA
1989 OSHA PEL 25 ppm (105 mg/m3) TWA, 40 ppm (170 mg/m3) STEL
1993-1994 ACGIH TLV 25 ppm (107 mg/m3) TWA, 40 ppm (172 mg/m3) STEL
Description of substance Colorless to straw-colored liquid with an ether-like odor.
LEL . . 2% (10% LEL, 2,000 ppm)
Original (SCP) IDLH 2,000 ppm
Basis for original (SCP) IDLH The chosen IDLH is based on the statement by ACGIH [1971] that the dog 4-hour LC50 is 2,000 to 2,500 ppm [Rinehart et al. 1958].
Short-term exposure guidelines None developed
ACUTE TOXICITY DATA
Lethal concentration data:

**Species**
    **Reference**
    **LC50** **(ppm)**
    **LCLo** **(ppm)**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived value**Rat
    Hood 1953
    -----
    10,000
    4 hr
    20,000 ppm (2.0)
    2,000 ppmRat
    Rinehart et al Mouse. 1958
    -----
    9,000 - 10,000
    4 hr
    18,000-20,000 ppm (2.0)
    1,800-2,000 ppmMouse
    Rinehart et al. 1958
    -----
    6,000 - 7,000
    4 hr
    12,000-14,000 ppm (2.0)
    1,200-1,400 ppmDog
    Rinehart et al. 1958
    -----
    2,000 - 2,500
    4 hr
    4,000- 5,000 ppm (2.0)
    400- 500 ppm**Human data** None relevant for use in determining the revised IDLH.
 
 **Revised IDLH:** 500 ppm **Basis for revised IDLH:** The revised IDLH for n-propyl nitrate is 500 ppm based on acute inhalation toxicity data in animals [Rinehart et al. 1958].**REFERENCES:**
1. ACGIH [1971]. n-Propyl nitrate. In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 217-218.
2. Hood DB [1953]. Toxicity of n-propyl nitrate and isopropyl nitrate. Report No. 21-53, Medical Research Project No. MR-170. Newark, DE: E.I. du Pont de Nemours & Co., Inc., Haskell Laboratory for Toxicology and Industrial Medicine.
3. Rinehart WE, Garbers RC, Greene EA, Stoufer RM [1958]. Studies on the toxicity of n-propyl nitrate vapor. Am Ind Hyg Assoc J *19*:80-83.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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