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Nitrobenzene																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 98–95–3
**NIOSH REL:** 1 ppm (5 mg/m3) TWA [skin]
**Current OSHA PEL:** 1 ppm (5 mg/m3) TWA [skin]
**1989 OSHA PEL:** Same as current PEL
**1993-1994 ACGIH TLV:** 1 ppm (5 mg/m3) TWA [skin]
**Description of substance:** Yellow, oily liquid with a pungent odor like paste shoe polish.
**LEL**(@200°F): 1.8% (10% LEL(@200°), 1,800 ppm)
**Original (SCP) IDLH:** 200 ppm
**Basis for original (SCP) IDLH:** The chosen IDLH is based on the statement by ACGIH [1971] and AIHA [1959] that Henderson and Haggard [1943] reported that 200 ppm is the maximum concentration that can be inhaled for 1 hour without serious disturbance.
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA:**
**Lethal dose data:**

**Species**
    **Reference**
    **Route**
    **LD50 (mg/kg)**
    **LDLo (mg/kg)**
    **Adjusted LD**
    **Derived value**Dog
    Flury and Zernik 1935
    oral
    -----
    750
    1,025 ppm
    103 ppmRat
    Kashkalda &d Kolodub 1988
    oral
    780
    -----
    1,066 ppm
    107 ppmRat
    Smyth et al. 1969
    oral
    600
    -----
    820 ppm
    82 ppmMouse
    Vasilenko & Zvezdai 1981
    oral
    590
    -----
    807 ppm
    81 ppm**Human data:** It has been reported that 200 ppm is the maximum concentration that can be inhaled for 1 hour without serious disturbance [Henderson and Haggard 1943].
 
 **Revised IDLH:** 200 ppm [Unchanged] **Basis for revised IDLH:** Based on acute inhalation toxicity data in humans [Henderson and Haggard 1943], the original IDLH for nitrobenzene (200 ppm) is not being revised at this time.**REFERENCES:**
1. ACGIH [1971]. Nitrobenzene. In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 183.
2. AIHA [1959]. Nitrobenzene. In: Hygienic guide series. Am Ind Hyg Assoc J *20*:66-67.
3. Flury F, Zernik F [1935]. Zusammenstellung der toxischen und letalen dosen für die gebräuchlichsten gifte und versuchstiere. Abder Hand Biol Arbeitsmethod *4*:1289-1422 (in German).
4. Henderson Y, Haggard HW [1943]. Noxious gases. 2nd ed. New York, NY: Reinhold Publishing Corporation, p. 228.
5. Kashkalda DA, Kolodub FA [1988]. Effect of para-nitrobenzol and 2,4-dinitrochlorobenzol on condition of hydrocarbon-energetic exchange in rats. Gig Tr Prof Zabol *32*(2):48-49 (in Russian).
6. Smyth HF Jr, Weil CS, West JS, Carpenter CP [1969]. An exploration of joint toxic action: twenty-seven industrial chemicals intubated in rats in all possible pairs. Toxicol Appl Pharmacol *14*:340-347.
7. Vasilenko NM, Zvezdai VI [1981]. Mathematical prognosing of toxicity data for nitro and amino compounds having a benzene ring. Gig Tr Prof Zabol *25*(8):50-52 (in Russian).

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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