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Isoamyl acetate																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 123–92–2
**NIOSH REL:** 100 ppm (525 mg/m3) TWA
**Current OSHA PEL:** 100 ppm (525 mg/m3) TWA
**1989 OSHA PEL:** Same as current PEL
**1993-1994 ACGIH TLV:** 100 ppm (532 mg/m3) TWA
**Description of substance:** Colorless liquid with a banana-like odor.
**LEL**(@212°F)**:** 1.0% (10% LEL(@212°F), 1,000 ppm)
**Original (SCP) IDLH:** 3,000 ppm
**Basis for original (SCP) IDLH:** The chosen IDLH is based on the statement by ACGIH [1971] that slight narcotic effects were noted in cats exposed for 6 hours at 2800 ppm [Flury and Wirth 1933]. This is the only useful data available on which to base the IDLH.
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA:**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50** **(ppm)**
    **LCLo** **(ppm)**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived value**Cat
    Flury and Wirth 1933
    -----
    6,470
    ?
    ?
    ?**Lethal dose data:**
 
 **Species**
    **Reference**
    **Route**
    **LD50** (mg/kg)
    **LDLo** (mg/kg)
    **Adjusted LD**
    **Derived value**Rabbit Rat
    Munch 1972 Yakkyoku 1981
    oral oral
    7,422 16,600
    ----- -----
    9,603 ppm 21,479 ppm
    960 ppm 2,148 ppm**Other animal data:** Slight narcotic effects were noted in cats exposed to 2,800 ppm for 6 hours [Flury and Wirth 1933].
 **Human data:** Isoamyl acetate is considered more irritating than butyl acetate. Exposure to 1,000 ppm for 30 minutes resulted in irritation, dyspnea, fatigue, and increased pulse [Amor 1950]. It is considered dangerous to life after 5 hours of exposure to 10,000 ppm [Browning 1965].
 
 **Revised IDLH:** 1,000 ppm **Basis for revised IDLH:** The revised IDLH for isoamyl acetate is 1,000 ppm based on acute toxicity data in humans [Amor 1950] and animals [Munch 1972]. This value is also equal to 10% of the lower explosive limit of 1% (which was determined at 212°F).**REFERENCES:**
1. ACGIH [1971]. Isoamyl acetate. In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 138-139.
2. Amor AJ [1950]. The toxicity of solvents. Paint Manufacture *20*:53-58.
3. Browning E [1965]. Toxicity and metabolism of industrial solvents. New York, NY: Elsevier Publishing Company, p. 539.
4. Flury F, Wirth W [1933]. Zur toxikologie der lösungsmittel (Verschieden ester, aceton, methylalkohol). Arch Gewerbepath Gewerbehyg *5*:1-90 (in German).
5. Munch JC [1972]. Aliphatic alcohols and alkyl esters: narcotic and lethal potencies to tadpoles and to rabbits. Ind Med Surg *41*(4):31-33.
6. Yakkyoku (Pharmacy) [1981]; *32*:1241-1247 (in Japanese).

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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