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Methylcyclohexanol																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 25639–42–3
**NIOSH REL:** 50 ppm (235 mg/m3) TWA
**Current OSHA PEL:** 100 ppm (470 mg/m3) TWA
**1989 OSHA PEL:** 50 ppm (235 mg/m3) TWA
**1993-1994 ACGIH TLV:** 50 ppm (234 mg/m3) TWA
**Description of substance:** Straw-colored liquid with a weak odor like coconut oil.
**LEL:**. . Unknown
**Original (SCP) IDLH:** 10,000 ppm
**Basis for original (SCP) IDLH:** No data on acute inhalation toxicity are available on which to base the IDLH for methylcyclohexanol. The chosen IDLH, therefore, has been estimated from the rabbit oral lethal dose of 1.75 to 2.0 g/kg [Treon et al. 1943 cited by Browning 1965]. Because this compound has such a low vapor pressure, a concentration this great can only be achieved if the substance is heated.
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA:**
**Lethal dose data:**

**Species**
    **Reference**
    **Route**
    **LD50** **(mg/kg)**
    **LDLo** **(mg/kg)**
    **Adjusted LD**
    **Derived value**Rat
    Deichmann & LeBlanc 1943
    oral
    1,660
    -----
    2,446 ppm
    245 ppmRabbit
    Treon et al. 1943a
    oral
    -----
    1,750-2,000
    2,579-2,947 ppm
    258-295 ppm**Other animal data:** Rabbits exposed for 6 hours/day, 5 days/week for 10 weeks at 503 ppm had increased salivation, conjunctival irritation, and slight lethargy, while 232 ppm caused no such signs of intoxication [Treon et al. 1943b].
 **Human data:** None relevant for use in determining the revised IDLH.
 
 **Revised IDLH:** 500 ppm **Basis for revised IDLH:** The revised IDLH for methylcyclohexanol is 500 ppm based on subchronic inhalation data in animals [Treon et al. 1943b]. This may be a conservative value due to the lack of relevant acute inhalation toxicity data for workers.**REFERENCES:**
1. Browning E [1965]. Toxicity and metabolism of industrial solvents. New York, NY: Elsevier Publishing Company, p. 372.
2. Deichmann WB, LeBlanc TJ [1943]. Determination of the approximate lethal dose with about six animals. J Ind Hyg Toxicol *25*(9):415-417.
3. Treon JF, Crutchfield WE Jr, Kitzmiller KV [1943a]. The physiological response of rabbits to cyclohexane, methylcyclohexane, and certain derivatives of these compounds. I. Oral administration and cutaneous application. J Ind Hyg Toxicol *25*(6):199-214.
4. Treon JF, Crutchfield WE, Kitzmiller KV [1943b]. The physiological response of animals to cyclohexane, methyl cyclohexane, and certain derivatives of these compounds. II. Inhalation. J Ind Hyg Toxicol *25*(8):323-347.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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