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Azinphos-methyl																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 86-50-0
**NIOSH REL:** 0.2 mg/m3 TWA [skin]
**Current OSHA PEL:** 0.2 mg/m3 TWA [skin]
**1989 OSHA PEL:** Same as current PEL
**1993-1994 ACGIH TLV:** 0.2 mg/m3 TWA [skin]
**Description of substance:** Colorless crystals or a brown, waxy solid.
**LEL:** Noncombustible Solid
**Original (SCP) IDLH:** 20 mg/m3
**Basis for original (SCP) IDLH:** Because no useful data on acute inhalation toxicity are available concerning the toxic effects produced by azinphos-methyl, the chosen IDLH has been based on an analogy with parathion, which has an IDLH of 20 mg/m3.
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA**

**Lethal concentration data:**
Species
    Reference
    LC50
    LCLo
    Time
    Adjusted 0.5-hr LC (CF)
    Derived ValueRat
    Newell and Dilley 1978
    69 mg/m3
    -----
    1 hr
    86 mg/m3 (1.25)
    8.6 mg/m3Rat
    Sanderson 1961
    79 mg/m3
    -----
    1 hr
    99 mg/m3 (1.25)
    9.9 mg/m3**Lethal dose data:**
 Species
    Reference
    Route
    LD50(mg/kg)
    LDLo(mg/kg)
    Adjusted LD
    Derived ValueRat
    Dubois et al. 1957
    oral
    16
    -----
    115 mg/m3
    12 mg/m3G. pig
    Dubois et al. 1957
    oral
    80
    -----
    560 mg/m3
    56 mg/m3Rat
    Gaines 1960
    oral
    11
    -----
    77 mg/m3
    7.7 mg/m3Rat
    Gaines 1960
    oral
    13
    -----
    91 mg/m3
    9.1 mg/m3Mouse
    Murphy et al. 1976
    oral
    8.6
    -----
    60 mg/m3
    6.0 mg/m3Rat
    Sanderson 1961
    oral
    7
    -----
    49 mg/m3
    4.9 mg/m3Mouse
    Sato 1959
    oral
    8
    -----
    56 mg/m3
    5.6 mg/m3Dog
    Worthing 1991
    oral
    10
    -----
    70 mg/m3
    7.0 mg/m3v**Human data:** Eight workers exposed to concentrations as high as 9.6 mg/m3 (no time period given) showed no signs or symptoms of illness [Jegler 1964].
 **Revised IDLH:** 10 mg/m3**Basis for revised IDLH:** The revised IDLH for azinphos-methyl is 10 mg/m3 based on acute inhalation toxicity data in humans [Jegler 1964] and animals [Newell and Dilley 1978; Sanderson 1961]. This may be a conservative value due to the lack of acute toxicity data for workers exposed to concentrations above 10 mg/m3.**REFERENCES:**
DuBois KP, Thursh DR, Murphy SD [1957]. Studies on the toxicity and pharmacologic actions of the dimethoxyl ester of benzotriazine dithiophosphoric acid. J Pharmacol Exp Ther *119*:208-218.
Gaines TB [1960]. Acute toxicity of pesticides in rats. Toxicol Appl Pharmacol *2*:88-99.
Jegler Z [1964]. Exposure to guthion during spraying and formulating. Arch Environ Health *8*:565-569.
Murphy SD, Cheever KL, Chow AYK, Brewster M [1976]. Organophosphate insecticide potentiation by carboxylesterase inhibitors. Proc Eur Soc Toxicol *17*:292-300.
Newell GW, Dilley JV [1978]. Teratology and acute toxicology of selected chemical pesticides administered by inhalation. Menlo Park, CA: Stanford Research Institute, p. 18. Prepared for Health Effects Research Laboratory, U.S. EPA, EPA-60011-78-003.
Sanderson DM [1961]. Treatment of poisoning by anticholinesterase insecticides in the rat. J Pharm Pharmacol *13*:435-442.
Sato I [1959]. Studies on organic phosphorus gusathion and phosdrin. I. The toxicity of gusathion and phosdrin. Kuma Med J *12*(1):312-317.
Worthing CR, ed. [1991]. Azinphos-methyl. In: The pesticide manual: a world compendium. 9th ed. Old Woking, Surrey, England: Unwin Brothers Limited, p. 46.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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