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Tetraethyl lead (as Pb)																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 78–00–2
**NIOSH REL:** 0.075 mg/m3 TWA [skin]
**Current OSHA PEL:** 0.075 mg/m3 TWA [skin]
**1989 OSHA PEL:** Same as current PEL
**1993-1994 ACGIH TLV:** 0.1 mg/m3 TWA [skin]
**Description of substance:** Colorless liquid (unless dyed red, orange, or blue) with a pleasant, sweet odor.
**LEL:** . . 1.8% (10% LEL, 1,800 ppm)
**Original (SCP) IDLH:** 40 mg Pb/m3
**Basis for original (SCP) IDLH:** The chosen IDLH is based on the rat LC50 of 6 ppm (approximately 80 mg/m3) [Saglik Dergisi 1963 cited by NIOSH 1974]. However, because of the unreliability of tetraethyl lead analytical methods utilized prior to 1968, 40 mg Pb/m3, which is approximately 50% of the LC50, has been utilized as the IDLH.
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA:**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50**
    **LCLo**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived value**Mouse
    Akatsuka 1973
    -----
    650 mg/m3
    7 hr
    999 mg Pb/m3 (2.4)
    100 mg Pb/m3Rat
    Cremer & Calloway 1961
    850 mg/m3
    -----
    1 hr
    680 mg Pb/m3 (1.25)
    68 mg Pb/m3**Lethal dose data:**
 
 **Species**
    **Reference**
    **Route**
    **LD50** **(mg/kg)**
    **LDLo** **(mg/kg)**
    **Adjusted LD**
    **Derived value**Rabbit RatRatRatRat
    Akatsuka 1973 Magistretti et al. 1963Schepers 1964Schroeder et al. 1972Springman et al. 1963
    oral oraloraloraloral
    ----- 351712.3-----
    30 ---------------24
    135 mg Pb/m3157 mg Pb/m376 mg Pb/m355 mg Pb/m3108 mg Pb/m3
    14 mg Pb/m316 mg Pb/m37.6 mg Pb/m35.5 mg Pb/m311 mg Pb/m3**Human data:** It has been stated that 100 mg Pb/m3 for 1 hour may produce illness [Fleming 1963].
 
 **Revised IDLH:** 40 mg Pb/m3 [Unchanged] **Basis for revised IDLH:** Based on acute inhalation toxicity data in humans [Fleming 1963] and animals [Akatsuka 1973; Cremer and Calloway 1961], a value of about 100 mg Pb/m3 would have been appropriate for tetraethyl lead. However, the original IDLH for tetraethyl lead (40 mg Pb/m3) is not being revised at this time.**REFERENCES:**
1. Akatsuka K [1973]. Tetraalkyl lead poisoning. Sangyo Igaku (Japanese Journal of Industrial Health) *15*:3-66.
2. Cremer JE, Calloway S [1961]. Further studies on the toxicity of some tetra and trialkyl lead compounds. Brit J Ind Med *18*:277-282.
3. Fleming AJ [1963]. Lead Symposium, Kettering Laboratory, University of Cincinnati, February 25-27, 1963.
4. Magistretti M, Zurlo N, Scollo F, Pacillo D [1963]. Tossicita comparata del piombo tetra-etile e del piombo tetra-metile. Med Lav *54*:486-495 (in Italian).
5. NIOSH [1974]. TP45500. Plumbane, tetraethyl-. In: The toxic substances list, 1974 ed. Rockville, MD: U.S. Department of Health, Education, and Welfare, Public Health Service, Center for Disease Control, National Institute for Occupational Safety and Health, DHEW (NIOSH) Publication No. 74-134, p. 634.
6. Saglik Dergisi [1963]; *38*:653.
7. Schepers GWH [1964]. Tetraethyl lead and tetramethyl lead comparative experimental pathology: Part I. Lead absorption and pathology. Arch Environ Health *8*:277-295.
8. Schroeder T, Avery DD, Cross HA [1972]. Tetraethyl lead dose response curve for mortality in laboratory rats. Experientia *28*:923-924.
9. Springman E, Bingham E, Stemmer KL [1963]. The acute effects of lead alkyls. Arch Environ Health *6*:469.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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