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2-Butanone																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 78–93–3
**NIOSH REL:** 200 ppm (590 mg/m3) TWA, 300 ppm (885 mg/m3) STEL
**Current OSHA PEL:** 200 ppm (590 mg/m3) TWA
**1989 OSHA PEL:** 200 ppm (590 mg/m3) TWA, 300 ppm (885 mg/m3) STEL
**1993-1994 ACGIH TLV:** 200 ppm (590 mg/m3) TWA, 300 ppm (885 mg/m3) STEL
**Description of Substance:** Colorless liquid with a moderately sharp, fragrant, mint- or acetone-like odor.
**LEL(@200EF):** 1.4% (10% LEL(@200EF), 1,400 ppm)
**Original (SCP) IDLH:** 3,000 ppm
**Basis for original (SCP) IDLH:** The chosen IDLH is based on the statement by Patty [1963] that a 2-hour exposure of rats to 2,000 ppm caused no deaths, but 4 of 6 rats exposed to 4,000 ppm for a 2-hour period died [Smyth 1956].
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA**
**Lethal concentration data:**


**Species**
    **Reference**
    **LC50** **(ppm)**
    **LCLo** **(ppm)**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived** **value**MammalMouseRatRat
    Esin and Vigdergauz 1986 Izmerov et al. 1982Pozzani et al. 1959Smyth 1956
    12,66713,3337,833LC67: 4,000
    --------------------
    ?2 hr8 hr2 hr
    ?21,333 ppm (1.6)19,583 ppm (2.5)6,400 ppm (1.6)
    ?2,133 ppm1,958 ppm640 ppm
 **Lethal dose data:**
 
 **Species**
    **Reference**
    **Route**
    **LD50** **(mg/kg)**
    **LDLo** **(mg/kg)**
    **Adjusted LD**
    **Derived** **value**Rat Mouse
    Kimura et al. 1971 Tanii et al. 1986
    oral oral
    2,737 4,050
    ----- -----
    6,386 ppm 9,450 ppm
    639 ppm 945 ppm
 **Human data:** It has been reported that 3,000 ppm is irritating to the eyes and nose [Patty et al. 1935].
 
 **Revised IDLH:** 3,000 ppm [Unchanged] **Basis for revised IDLH:** Based on acute inhalation toxicity data in humans [Patty et al. 1935], the original IDLH for 2-butanone (3,000 ppm) is not being revised at this time.
**REFERENCES:**
1. Esin MS, Vigdergauz MS [1986]. Correlation between toxicity indexes and chromatographic characteristics of chemical substances. Gig Sanit *51*(5):61-62 (in Russian).
2. Izmerov NF, Sanotsky IV, Sidorov KK [1982]. Toxicometric parameters of industrial toxic chemicals under single exposure. Moscow, Russia: Centre of International Projects, GKNT, p. 83.
3. Kimura ET, Ebert DM, Dodge PW [1971]. Acute toxicity and limits of solvent residue for sixteen organic solvents. Toxicol Appl Pharmacol *19*:699-704.
4. Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 1733.
5. Patty FA, Schrenk HH, Yant WP [1935]. Acute response of guinea pigs to vapors of some new commercial organic compounds. VIII. Butanone. Public Health Rep *50*:1217-1228.
6. Pozzani UC, Weil CS, Carpenter CP [1959]. The toxicological basis of threshold limit values: 5. The experimental inhalation of vapor mixtures by rats, with notes upon the relationship between single dose inhalation and single dose oral data. Am Ind Hyg Assoc J *20*:364-369.
7. Smyth HF Jr [1956]. Improved communication: hygienic standards for daily inhalation. Am Ind Hyg Assoc Q *17*(2):129-185.
8. Tanii H, Tsuji H, Hashimoto K [1986]. Structure-toxicity relationship of monoketones. Toxicol Lett *30*:13-17.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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