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Dichlorvos																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 62–73–7
**NIOSH REL:** 1 mg/m3 TWA [skin]
**Current OSHA PEL:** 1 mg/m3 TWA [skin]
**1989 OSHA PEL:** Same as current PEL
**1993-1994 ACGIH TLV:** 0.90 mg/m3 (0.1 ppm) TWA [skin]
**Description of Substance:** Colorless to amber liquid with a mild, chemical odor.
**LEL:**. . Unknown
**Original (SCP) IDLH:** 200 mg/m3
**Basis for original (SCP) IDLH:** No useful data on acute inhalation toxicity are available on which to base the IDLH for dichlorvos. If the IDLH were estimated from the female rat oral LD50 of 55 mg/kg [Mattson et al. 1955 cited by Patty 1963], an IDLH of 400 mg/m3 would be chosen. On the basis of an analogy with parathion, however, which has an OSHA PEL of 0.1 mg/m3 and an IDLH of 20 mg/m3, an IDLH of 200 mg/m3 has been chosen for dichlorvos which has an OSHA PEL of 1 mg/m3.
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50**
    **LCLo**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived** **value**Rat Mouse
    Gig Sanit 1968 Gig Sanit 1968
    15 mg/m313 mg/m3
    ----- -----
    4 hr 4 hr
    30 mg/m3 (2.0) 16 mg/m3 (2.0)
    3.0 mg/m32.6 mg/m3
 **Lethal dose data:**
 
 **Species**
    **Reference**
    **Route**
    **LD50** **(mg/kg)**
    **LDLo** **(mg/kg)**
    **Adjusted LD**
    **Derived value**Dog MouseRabbitRat
    Hartley and Kidd 1984 Ikuzawa et al. 1966Kokshareva et al. 1977Technical News 1972
    oral oraloraloral
    100 611017
    ----- ---------------
    700 mg/m3427 mg/m370 mg/m3119 mg/m3
    70 mg/m343 mg/m37.0 mg/m312 mg/m3
 **Human data:** Exposure to a concentration of 1 mg/m3 for 7.5 to 8.5 hours resulted in a plasma cholinesterase depression of 20 to 25% [Hunter 1964].
 
 **Revised IDLH:** 100 mg/m3**Basis for revised IDLH:** The revised IDLH for dichlorvos is 100 mg/m3 based on an analogy to parathion. Since the toxicity of dichlorvos is about 10 times lower than parathion (based on acute oral toxicity data in animals), the revised IDLH for dichlorvos is 10 times the revised IDLH for parathion (10 mg/m3).
**REFERENCES:**
1. Gig Sanit [1968]; *33*(10):35 (in Russian).
2. Hartley D, Kidd H, eds. [1984]. Agrochemical handbook. Nottingham, England: Royal Society of Chemistry, 1983-86, p. A141.
3. Hunter C [1964]. Communication to TLV Committee from Tunstall Laboratory, Sittingbourne, Kent, England. [From ACGIH [1991]. Dichlorvos. In: Documentation of the threshold limit values and biological exposure indices. 6th ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 446-448.]
4. Ikuzawa M, Yonemoto S, Aoki H, Sumimoto S, Matsumoto K, Ohara K [1966]. Studies on the toxicity of various insecticides for mice (I) on the oral acute toxicity of single and mixed insecticides. J Osaka Cty Med Cntr *15*:553-563.
5. Kokshareva NV, Kovtun SD, Kagan YS, Mizyukova IG, Medvedev BM [1977]. Action of diethixime, a new cholinesterase reactivator, on the central nervous system. Bulletin Exp Biol Med *83*:32-35.
6. Mattson AM, Spillane JT, Pearce GW [1955]. Organophosphorus insecticides: dimethyl 2,2-dichlorovinyl phosphate (DDVP), an organic phosphorus compound highly toxic to insects. J Agri Food Chem *3*(4):319-321.
7. Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 1942.
8. Technical news: ortran. [1972]. Japan Pesticide Information No. 13, pp. 36-38.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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