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sec-Hexyl acetate																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 108–84–9
**NIOSH REL:** 50 ppm (300 mg/m3) TWA
**Current OSHA PEL:** 50 ppm (300 mg/m3) TWA
**1989 OSHA PEL:** Same as current PEL
**1993-1994 ACGIH TLV:** 50 ppm (295 mg/m3) TWA
**Description of Substance:** Colorless liquid with a mild, pleasant, fruity odor.
**LEL:**. . Unknown
**Original (SCP) IDLH:** 4,000 ppm
**Basis for original (SCP) IDLH:** The chosen IDLH is based on the statement by ACGIH [1971] that 2 of 6 rats died from a 4-hour exposure to 4,000 ppm [Smyth et al. 1954].
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50** **(ppm)**
    **LCLo** **(ppm)**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived** **value**Rat Rat
    Smyth et al. 1954 UCC 1966
    LC33: 4,000 -----
    ----- 2,000
    4 hr 4 hr
    8,000 ppm (2.0) 4,000 ppm (2.0)
    800 ppm 400 ppm
 **Lethal dose data:**
 
 **Species**
    **Reference**
    **Route**
    **LD50** **(mg/kg)**
    **LDLo** **(mg/kg)**
    **Adjusted LD**
    **Derived value**Rat
    UCC 1966
    oral
    6,160
    -----
    7,187 ppm
    719 ppm
 **Human data:** Volunteers noted an unpleasant odor and irritation of the eyes and upper respiratory tract at 100 ppm [Silverman et al. 1946].
 
 **Revised IDLH:** 500 ppm **Basis for revised IDLH:** The revised IDLH for sec-hexyl acetate is 500 ppm based on acute inhalation toxicity data in humans [Silverman et al. 1946] and animals [Smyth et al. 1954; UCC 1966].
**REFERENCES:**
1. ACGIH [1971]. sec-Hexyl acetate. In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 127.
2. Silverman L, Schulte HF, First MW [1946]. Further studies on sensory response to certain industrial solvent vapors. J Ind Hyg Toxicol *28*:262-266.
3. Smyth HF Jr, Carpenter CP, Weil CS, Pozzani UC [1954]. Range-finding toxicity data: list V. AMA Arch Ind Hyg Occup Med *10*:61-68.
4. UCC [1966]. Toxicology studies: methyl amyl acetate. New York, NY: Union Carbide Corporation, Industrial Medicine and Toxicology Department (7/28/66).

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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