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Chlorinated camphene																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 8001–35–2
**NIOSH REL:** None established; NIOSH considers chlorinated camphene to be a potential occupational carcinogen as defined by the OSHA carcinogen policy [29 CFR 1990].
**Current OSHA PEL:** 0.5 mg/m3 TWA [skin]
**1989 OSHA PEL:** 0.5 mg/m3 TWA, 1 mg/m3 STEL [skin]
**1993-1994 ACGIH TLV:** 0.5 mg/m3 TWA, 1 mg/m3 STEL [skin]
**Description of Substance:** Amber, waxy solid with a mild, piney, chlorine- and camphor-like odor.
**LEL:** . . Noncombustible Solid
**Original (SCP) IDLH:** 200 mg/m3
**Basis for original (SCP) IDLH:** The chosen IDLH has been estimated from the statement by Patty [1963] from the Council on Pharmacy and Chemistry [1952], Deichmann and Gerarde [1969], Stolman [1969], Thienes and Haley [1972], and Sax [1968] that the human oral lethal dose is about 2 to 7 grams.
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50**
    **LCLo**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived** **value**Mouse
    Wermer 1952
    -----
    2,000 mg/m3
    2 hr
    3,200 mg/m3 (1.6)
    320 mg/m3
 **Lethal dose data:**
 
 **Species**
    **Reference**
    **Route**
    **LD50** **(mg/kg)**
    **LDLo** **(mg/kg)**
    **Adjusted LD**
    **Derived** **value**Rabbit MouseG. pigRat
    Hartley and Kidd 1983-86 Kenaga and Morgan 1978Perkow 1971/76von Schwabe and Wendling 1967
    oral oraloraloral
    75 11225050
    ----- ---------------
    525 mg/m3784 mg/m31,750 mg/m3350 mg/m3
    53 mg/m378 mg/m3175 mg/m335 mg/m3
 **Human data:** No toxic responses were noted in 25 volunteers exposed to 500 mg/m3 for 30 minutes/day for 10 consecutive days [Shelansky 1947]. The oral lethal dose has been reported to be about 2 to 7 grams [Thienes and Haley 1972]. [Note: An oral dose of 2 to 7 grams is equivalent to a worker being exposed to about 1,300 to 4,700 mg/m3 for 30 minutes, assuming a breathing rate of 50 liters per minute and 100% absorption.]
 
 **Revised IDLH:** 200 mg/m3 [Unchanged] **Basis for revised IDLH:** Based on acute inhalation toxicity data in humans [Shelansky 1947], a value of about 500 mg/m3 would have been appropriate. However, the original IDLH of 200 mg/m3 is not being revised at this time. [Note: NIOSH recommends as part of its carcinogen policy that the "most protective" respirators be worn for chlorinated camphene at any detectable concentration.]
**REFERENCES:**
1. Deichmann WB, Gerarde HW [1969]. Toxaphene (synthetic 3956; chlorinated camphene). In: Toxicology of drugs and chemicals. New York, NY: Academic Press, Inc., p. 598.
2. Hartley D, Kidd H [1983-86]. The agrochemicals handbook. Nottingham, England: Royal Society of Chemistry, p. A054.
3. Kenaga EE, Morgan RW [1978]. Commercial and experimental organic insecticides (1978 revision). Entomological Society of America, Special Publication *78-1*:13.
4. Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 1360.
5. Perkow W [1971/76]. Wirksubstanzen der pflanzenschutz und schadlingsbekampfungsmittel. Berlin, Germany: Verlag Paul Parey (in German).
6. Sax NI [1968]. Dangerous properties of industrial materials. 3rd ed. New York, NY: Van Nostrand Reinhold Company, p. 1172.
7. Shelansky H [1947]. Unpublished report to Hercules, Inc. In: ACGIH [1971]. Chlorinated camphene (60%). In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 115.
8. Stolman A, ed. [1969]. Progress in chemical toxicology. Vol. 4. New York, NY: Academic Press, p. 195.
9. Stormont RT, Conley BE [1952]. Report to the Council on Pharmacy and Chemistry: pharmacologic properties of toxaphene, a chlorinated hydrocarbon insecticide. JAMA *149*(12):1135-1137.
10. Thienes CH, Haley TJ [1972]. Clinical toxicology. 5th ed. Philadelphia, PA: Lea & Febiger, pp. 26-27.
11. von Schwabe V, Wendling I [1967]. Beschleunigung des arzneimittel-abbaus durch kleine dosen von DDT und anderen chlorkoblenwasserstoff-insekticiden. Arzneimittel-Forschung (Drug Research) *17*:614-618 (in German).
12. Wermer PL [1952]. Pharmacological properties of toxaphene, a chlorinated hydrocarbon insecticide. JAMA *149*:1135-1137.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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