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Di-sec octyl phthalate																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 117–81–7
**NIOSH REL:** 5 mg/m3 TWA, 10 mg/m3 STEL; NIOSH considers di-sec octyl phthalate to be a potential occupational carcinogen as defined by the OSHA carcinogen policy [29 CFR 1990].
**Current OSHA PEL:** 5 mg/m3 TWA
**1989 OSHA PEL:** 5 mg/m3 TWA, 10 mg/m3 STEL
**1993-1994 ACGIH TLV:** 5 mg/m3 TWA, 10 mg/m3 STEL
**Description of Substance:** Colorless, oily liquid with a slight odor.
**LEL**(@474 F): 0.3% (10% LEL(@474 F), 8,600 mg/m3)
**Original (SCP) IDLH*:** Unknown [*Note: “Effective” IDLH = 5,000 mg/m3 — see discussion below.]
**Basis for original (SCP) IDLH:** Patty [1963] made the statement that inhalation of the vapor-mist mixture produced by bubbling air through a column of plasticizer maintained at 170 C could be tolerated for 2 hours without producing fatalities. In a 4-hour period, however, all rats had succumbed. On the basis of these experiments, the hazard to exposed workers should be very low under ordinary circumstances. Because di-sec octyl phthalate has such a low toxicity, respirators have been selected on the basis of the assigned protection factor afforded by each device up to 1,000 × the OSHA PEL of 5 mg/m3 (i.e., 5,000 mg/m3); only the “most protective” respirators are permitted for use in concentrations exceeding 5,000 mg/m3.
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA**
**Lethal dose data:**

**Species**
    **Reference**
    **Route**
    **LD50** **(mg/kg)**
    **LDLo** **(mg/kg)**
    **Adjusted LD**
    **Derived value**Rabbit G. pigRatMouse
    Autian 1973 Autian 1973Shibko and Blumenthal 1973Yagi et al. 1976
    oral oraloraloral
    34,000 26,00030,60030,000
    ----- ---------------
    238,000 mg/m3182,000 mg/m3214,200 mg/m3210,000 mg/m3
    23,800 mg/m318,200 mg/m321,420 mg/m321,000 mg/m3
 **Human data:** None relevant for use in determining the revised IDLH.
 
 **Revised IDLH:** 5,000 mg/m3**Basis for revised IDLH:** No inhalation toxicity data are available on which to base an IDLH for di-sec octyl phthalate. Since the acute oral toxicity data in animals [Autian 1973; Shibko and Blumenthal 1973; Yagi et al. 1976] indicates that di-sec octyl phthalate has low acute toxicity, the revised IDLH for di-sec octyl phthalate is 5,000 mg/m3 based on being 1,000 times the OSHA PEL of 5 mg/m3 (1,000 is an assigned protection factor for respirators and was used during the Standards Completion Program for deciding when the "most protective" respirators should be used for di-sec octyl phthalate). [Note: NIOSH recommends as part of its carcinogen policy that the "most protective" respirators be worn for di-sec octyl phthalate at concentrations above 5 mg/m3.]
**REFERENCES:**
1. Autian J [1973]. Toxicity and health threats of phthalate esters: review of the literature. Environ Health Perspect *4*:3-26.
2. Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 1909.
3. Shibko SI, Blumenthal H [1973]. Toxicology of phthalic acid esters used in food-packaging material. Environ Health Perspect *3*:131-137.
4. Yagi Y, Tutikawa K, Shimoi N [1976]. Teratogenicity and mutagenicity of a phthalate ester. Int J Abnorm Develop *14*(2):259 [Abstract].

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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