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Aniline																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 62-53-3
**NIOSH REL:** None established; NIOSH considers aniline to be a potential occupational carcinogen as defined by the OSHA carcinogen policy [29 CFR 1990].
**Current OSHA PEL:** 5 ppm (19 mg/m3) TWA [skin]
**1989 OSHA PEL:** 2 ppm (8 mg/m3) TWA [skin]
**1993-1994 ACGIH TLV:** 2 ppm (7.6 mg/m3) TWA [skin]
**Description of substance:** Colorless to brown, oily liquid with an aromatic amine-like odor.
**LEL:** 1.3% (10% LEL, 1,300 ppm)
**Original (SCP) IDLH:** 100 ppm
**Basis for original (SCP) IDLH:** The chosen IDLH is based on the statement by Henderson and Haggard [1943] that 100 to 160 ppm is the maximum concentration that can be inhaled for 1 hour without serious disturbance. AIHA [1955] reported that 50 to 100 ppm can probably be tolerated for 60 minutes.
**Short-term exposure guidelines:** None developed
ACUTE TOXICITY DATA
**Lethal concentration data:**
AdjustedLC50
    LCLo
    
    0.5-hr
    DerivedSpecies
    Reference
    (ppm)
    (ppm)
    Time
    LC (CF)
    ValueMouse
    Back et al. 1972
    175
    -----
    7 hr
    420 ppm (2.4)
    42 ppmRat
    Carpenter et al. 1949
    -----
    250
    4 hr
    500 ppm (2.0)
    50 ppmCat
    von Oettingen 1941
    -----
    180
    8 hr
    450 ppm (2.5)
    45 ppm**Lethal dose data:** 
 LD50
    LDLo
    
    DerivedSpecies
    Reference
    Route
    (Mg/kg)
    (mg/kg)
    Adjusted LD
    ValueDog
    Back et al. 1972
    oral
    -----
    195
    353 ppm
    35 ppmRat
    Dieke et al. 1947
    oral
    -----
    250
    452 ppm
    45 ppmMouse
    Gig Tr Prof Zabol
    oral
    -----
    464
    839 ppm
    84 ppmRat
    Jacobsen 1972
    oral
    -----
    440
    796 ppm
    80 ppmG. pig
    Kodak 1984
    oral
    -----
    400
    724 ppm
    72 ppm**Human data:** Volunteers tolerated 1-hour exposures ranging from 100-160 ppm with only moderate adverse health effects (undefined) [von Oettingen 1941]. It has also been reported that 100 to 160 ppm is the maximum concentration that can be inhaled for 1 hour without serious consequence [Henderson and Haggard 1943] and that 50 to 100 ppm can probably be tolerated for 60 minutes [AIHA 1955].
 **Revised IDLH:** 100 ppm [Unchanged]**Basis for revised IDLH:** Based on acute inhalation toxicity data in humans [AIHA 1955; Henderson and Haggard 1943; von Oettingen 1941], the original IDLH for aniline of 100 ppm is not being revised at this time. [Note: NIOSH recommends as part of its carcinogen policy that the "most protective" respirators be worn for aniline at any detectable concentration.]References:
AIHA [1955]. Aniline. In: Hygienic guide series. Am Ind Hyg Assoc Q *16*:331-332.
Back KC, Thomas AA, MacEwen JD [1972]. Reclassification of materials listed as transportation health hazards. Wright-Patterson Air Force Base, OH: 6570th Aerospace Medical Research Laboratory, Report No. TSA-20-72-3, pp. A-8 to A-9.
Carpenter CP, Smyth HF Jr, Pozzani UC [1949]. The assay of acute vapor toxicity, and the grading and interpretation of results on 96 chemical compounds. J Ind Hyg Toxicol *31*:343-346.
Dieke SH, Allen GS, Richter CP [1947]. The acute toxicity of thioureas and related compounds to wild and domestic Norway rats. J Pharmacol Exp Ther *90*:260-270.
Gig Tr Prof Zabol [1969]; *13*(5):29-32 (in Russian).
Henderson Y, Haggard HW [1943]. Noxious gases. 2nd ed. New York, NY: Reinhold Publishing Corporation, p. 228.
Jacobsen KH [1972]. Acute oral toxicity of mono- and di-alkyl ring-substituted derivatives of aniline. Toxicol Appl Pharmacol *22*:153-154.
Kodak [1984]. Aniline. In: TSCA 8d submission to U.S. Environmental Protection Agency (OTS 206512). Rochester, NY: Eastman Kodak Company.
von Oettingen WF [1941]. The aromatic amines and nitro compounds, their toxicity and potential dangers. Washington, DC: Government Printing Office, U.S. Public Health Service, Public Health Bulletin *271*:1-15.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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