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Quinone																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 106–51–4
**NIOSH REL:** 0.4 mg/m3 (0.1 ppm) TWA
**Current OSHA PEL:** 0.4 mg/m3 (0.1 ppm) TWA
**1989 OSHA PEL:** Same as current PEL
**1993-1994 ACGIH TLV:** 0.44 mg/m3 (0.1 ppm) TWA
**Description of substance:** Pale-yellow solid with an acrid, chlorine-like odor.
**LEL:** . . . Unknown
**Original (SCP) IDLH:** 300 mg/m3
**Basis for original (SCP) IDLH:** The chosen IDLH is based on the mouse LCLO of 320 mg/m3 [Zabolevanii 1962 cited by NIOSH 1976]. No other data on acute inhalation toxicity are available on which to base the IDLH.
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA:**
**Lethal dose data:**

**Species**
    **Reference**
    **Route**
    **LD50** **(mg/kg)**
    **LDLo** **(mg/kg)**
    **Adjusted LD**
    **Derived value**Mammal MouseMouseRatRatRat
    Izmerov et al. 1982 Marquardt et al. 1947Serif & Seymour 1963Tomchin et al. 1978Woodward et al. 1949Woodward et al. 1949
    s.c. s.c.i.p.?orali.v.
    296 93.88.55.613025
    ----- -------------------------
    2,072 mg/m3657 mg/m360 mg/m339 mg/m3910 mg/m3175 mg/m3
    207 mg/m366 mg/m36.0 mg/m33.9 mg/m391 mg/m318 mg/m3**Human data:** None relevant for use in determining the revised IDLH.
 
 **Revised IDLH:** 100 mg/m3**Basis for revised IDLH:** No inhalation toxicity data are available on which to base an IDLH for quinone. Therefore, the revised IDLH for quinone is 100 mg/m3 based on acute oral toxicity data in animals [Woodward et al. 1949]. This may be a conservative value due to the lack of relevant acute toxicity data for workers.**REFERENCES:**
1. Izmerov NF, Sanotsky IV, Sidorov KK [1982]. Toxicometric parameters of industrial toxic chemicals under single exposure. Moscow, Russia: Centre of International Projects, GKNT, p. 25.
2. Marquardt P, Koch R, Aubert J-P [1947]. Die toxizität der ein-, zwei- und dreiwertigen phenole. Zeit Ges Med Gren *2*:333 (in German).
3. NIOSH [1976]. DK26250. p-Benzoquinone. In: Registry of toxic effects of chemical substances, 1976 ed. Rockville, MD: U.S. Department of Health, Education, and Welfare, Public Health Service, Center for Disease Control, National Institute for Occupational Safety and Health, DHEW (NIOSH) Publication No. 76-191, p. 202.
4. Serif GS, Seymour LE [1963]. Catabolism and excretion of the antithyroid substance, diacetyl-2,6-diiodohydroquinone. Biochem Pharmacol *12*:885-891.
5. Tomchin AB, Aleksandrova AE, Vinogradov VM [1978]. Structure and anti-hypoxic activity of alpha-dicarbonyl compounds and their derivatives. Farmakol Toxsikol *41*(4):482-491 (in Russian).
6. Woodward G, Hagan EC, Radomski JL [1949]. Toxicity of hydroquinone for laboratory animals. Fed Proc *8*:348.
7. Zabolevanii Prof. Khim. Etiol. Sb. [1962]. Prom Toksikol Klin, p. 137 (in Russian). [From NIOSH [1976]. DK26250. p-Benzoquinone. In: Registry of toxic effects of chemical substances, 1976 ed. Rockville, MD: U.S. Department of Health, Education, and Welfare, Public Health Service, Center for Disease Control, National Institute for Occupational Safety and Health, DHEW (NIOSH) Publication No. 76-191, p. 202.]

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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