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TEPP																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 107–49–3
**NIOSH REL:** 0.05 mg/m3 TWA [skin]
**Current OSHA PEL:** 0.05 mg/m3 TWA [skin]
**1989 OSHA PEL:** Same as current PEL
**1993-1994 ACGIH TLV:** 0.004 ppm (0.47 mg/m3) TWA [skin]
**Description of substance:** Colorless to amber liquid with a faint, fruity odor.
**LEL** : . . Noncombustible Liquid
**Original (SCP) IDLH:** 10 mg/m3
**Basis for original (SCP) IDLH:** The chosen IDLH is based on the estimated oral lethal dose in man of 100 mg cited by Patty [1963].
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA**
**Lethal dose data:**

**Species**
    **Reference**
    **Route**
    **LD50** **(mg/kg)**
    **LDLo** **(mg/kg)**
    **Adjusted LD**
    **Derived value**Rat
    Edson 1960
    oral
    -----
    0.5
    3.5 mg/m3
    0.4 mg/m3G. pig
    Frawley et al. 1952
    oral
    -----
    2.3
    16 mg/m3
    1.6 mg/m3Mouse
    Kamimura et al. 1963
    oral
    -----
    3
    21 mg/m3
    2.1 mg/m3**Human data:** TEPP, a cholinesterase inhibitor, has been judged to be twice as toxic as parathion; the American Conference of Governmental Industrial Hygienists TLV for TEPP was based on an analogy to parathion and was half that selected for parathion [ACGIH 1986]. It has been reported that the lethal oral dose is 1.429 mg/kg [CDC 1956; Patty 1963]. [Note: An oral dose of 1.429 mg/kg is equivalent to a 70-kg worker being exposed to 67 mg/m3 for 30 minutes assuming a 50 liter per minute breathing rate and 100% absorption.]
 
 **Revised IDLH:** 5 mg/m3**Basis for revised IDLH:** No inhalation data are available on which to base an IDLH for TEPP. Therefore, the revised IDLH for TEPP is 5 mg/m3 based on acute oral toxicity data in humans [CDC 1956; Patty 1963] and an analogy to parathion [ACGIH 1986] which has a revised IDLH of 10 mg/m3.**REFERENCES:**
1. ACGIH [1986]. TEPP. In: Documentation of the threshold limit values and biological exposure indices. 5th ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 558.
2. CDC [1956]. Clinical memoranda on economic poisons. Atlanta, GA: Communicable Disease Center, Bureau of State Services, Public Health Service, U.S. Department of Health, Education, and Welfare, Public Health Service Publication No. 476, pp. 21-23.
3. Edson EF [1960]. Applied toxicology of pesticides. Pharmaceut J *185*:361-367.
4. Frawley JP, Hagan EC, Fitzhugh OG [1952]. A comparative pharmacological and toxicological study of organic phosphateÄanticholinesterase compounds. J Pharmacol Exp Ther *105*:156-165.
5. Kamimura H, Matsumoto A, Miyazaki Y, Yamamoto I [1963]. Studies on nicotinoids as an insecticide. Part IV. Relation of structure to toxicity of pyridylmethylamines. Agri Biol Chem *27*(10):684-688.
6. Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 1956.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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