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Chloroacetaldehyde																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 107–20–0
**NIOSH REL:** 1 ppm (3 mg/m3) CEILING
**Current OSHA PEL:** 1 ppm (3 mg/m3) CEILING
**1989 OSHA PEL:** Same as current PEL
**1993-1994 ACGIH TLV:** 1 ppm (3.2 mg/m3) CEILING
**Description of Substance:** Colorless liquid with an acrid, penetrating odor.
**LEL:** . . Unknown
**Original (SCP) IDLH:** 100 ppm
**Basis for original (SCP) IDLH:** The chosen IDLH is based on an analogy with crotonaldehyde. Rinehart [1967] found 100 ppm crotonaldehyde to be a lethal concentration for rats for a 4-hour exposure; the LC50 for 30 minutes was 600 ppm. Human subjects found 45 ppm crotonaldehyde very disagreeable and conjunctival irritation was observed [Dow 1962 as cited by ACGIH 1971]. Based on the data cited above for crotonaldehyde, an IDLH of 100 ppm is chosen for chloroacetaldehyde.
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50** **(ppm)**
    **LCLo** **(ppm)**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived** **value**Rat
    EPA 1987
    200
    -----
    1 hr
    250 ppm (1.25)
    25 ppm
 **Lethal dose data:**
 
 **Species**
    **Reference**
    **Route**
    **LD50** **(mg/kg)**
    **LDLo** **(mg/kg)**
    **Adjusted LD**
    **Derived value**Rat Mouse
    Lawrence et al. 1972 Lawrence et al. 1972
    oral oral
    89 82
    ----- -----
    191 ppm 176 ppm
    19 ppm 18 ppm
 **Human data:** Volunteers found 45 ppm to be very disagreeable and conjunctival irritation was observed [Dow 1962].
 
 **Revised IDLH:** 45 ppm **Basis for revised IDLH:** The revised IDLH for chloroacetaldehyde is 45 ppm based on acute inhalation toxicity data in humans [Dow 1962]. This may be a conservative value due to the lack of relevant acute toxicity data for workers exposed to concentrations above 45 ppm.
**REFERENCES:**
1. ACGIH [1971]. Crotonaldehyde. In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 62-63.
2. Dow [1962]. Personal communication to a ACGIH TLV Committee member from the Dow Chemical Company, Biochemical Research Department.
3. EPA [1987]. TSCA section 8e submission and status report on chloroacetone and chloroacetaldehyde. Washington, DC: U.S. Environmental Protection Agency, Office of Toxic Substances, Report No. 8EHQ-0387-0660, April 22, 1987.
4. Lawrence WH, Dillingham EO, Turner JE [1972]. Toxicity profile of chloracetaldehyde. J Pharm Sci *61*:19-25.
5. Rinehart WE [1967]. The effect on rats of single exposures to crotonaldehyde vapor. Am Ind Hyg Assoc J *28*:561-566.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
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