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n-Amyl acetate																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 628-63-7
**NIOSH REL:** 100 ppm (525 mg/m3) TWA
**Current OSHA PEL:** 100 ppm (525 mg/m3) TWA
**1989 OSHA PEL:** Same as current PEL
**1993-1994 ACGIH TLV:** 100 ppm (532 mg/m3) TWA
**Description of substance:** Colorless liquid with a persistent banana-like odor.
**LEL:** 1.1% (10% LEL, 1,100 ppm)
**Original (SCP) IDLH:** 4,000 ppm
**Basis for original (SCP) IDLH:** The chosen IDLH is based on the statement by Browning [1965] that exposure to 4,000 ppm of a mixture of n-amyl acetate and isoamyl acetate produced complete loss of reflexes in rabbits within an hour [Koelsch 1912], and on the statement by Sax [1975] that 5,000 ppm n-amyl acetate produced deep narcosis in cats in 30 minutes.
**Short-term exposure guidelines:** None developed
ACUTE TOXICITY DATA
**Lethal concentration data:**
AdjustedLC50
    LCLo
    
    0.5-hr
    DerivedSpecies
    Reference
    (ppm)
    (ppm)
    Time
    LC (CF)
    ValueRat
    NPIRI 1974
    -----
    5,200
    ?
    ?
    ?**Lethal dose data:** 
 LD50
    LDLo
    
    DerivedSpecies
    Reference
    Route
    (Mg/kg)
    (mg/kg)
    Adjusted LD
    ValueRabbit
    Marhold 1986
    oral
    7,400
    -----
    9,575 ppm
    958 ppmRat
    NPIRI 1974
    oral
    6,500
    -----
    8,410 ppm
    841 ppm**Other animal data:** RD50 (mouse), 1,531 ppm [Alarie 1981].
 **Human data:** Somnolence has been reported after exposure to 952 ppm for 30 minutes [Lehmann 1913].
 **Revised IDLH:** 1,000 ppm**Basis for revised IDLH:** The revised IDLH for n-amyl acetate is 1,000 ppm based on acute toxicity data in humans [Lehmann 1913] and animals [Alarie 1981; Marhold 1986].References:
Alarie Y [1981]. Dose-response analysis in animal studies: prediction of human responses. Environ Health Perspect *42*:9-13.
Browning E [1965]. Toxicity and metabolism of industrial solvents. New York, NY: Elsevier Publishing Company, p. 539.
Koelsch [1912]. Damage to health by amyl acetate. Concordia No. 12.
Lehmann KB [1913]. Experimentelle studien uber den einflufs technisch wichtiger gase und dampfe auf den organimus (XXXII/XXXIII). Amylazetat und cyclohexanolazetat. Arch Hyg *78*:260-273 (in German).
Marhold J [1986]. Prehled prumyslove toxikologie: organicke latky. Prague, Czechoslovakia: Avicenum, p. 357 (in Czechoslovakian).
NPIRI [1974]. Raw materials data handbook, physical and chemical properties, fire hazard and health hazard data. Vol. 1. Organic solvents. Bethlehem, PA: National Printing Ink Research Institute, p. 3.
Sax NI [1975]. Dangerous properties of industrial materials. 4th ed. New York, NY: Van Nostrand Reinhold Company, Inc., p. 398.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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