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Cyclohexanol																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 108–93–0
**NIOSH REL:** 50 ppm (200 mg/m3) TWA [skin]
**Current OSHA PEL:** 50 ppm (200 mg/m3) TWA
**1989 OSHA PEL:** 50 ppm (200 mg/m3) TWA [skin]
**1993-1994 ACGIH TLV:** 50 ppm (206 mg/m3) TWA [skin]
**Description of Substance:** Sticky solid or colorless to light-yellow liquid (above 77 F) with a camphor-like odor.
**LEL:** . . Unknown
**Original (SCP) IDLH:** 3,500 ppm
**Basis for original (SCP) IDLH:** No acute inhalation toxicity data are available on which to base an IDLH for cyclohexanol. The chosen IDLH, therefore, has been estimated from the rabbit oral LD50 of 2.2 to 2.6 g/kg [Treon et al. 1943 cited in Browning 1965]. The chosen IDLH of 3,500 ppm (14.3 g/m3) is probably conservative, because the lower end of the range of the LD50 values (i.e., 2.2 g/kg) has been used to estimate the IDLH.
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA**
**Lethal dose data:**

**Species**
    **Reference**
    **Route**
    **LD50** **(mg/kg)**
    **LDLo** **(mg/kg)**
    **Adjusted LD**
    **Derived value**Rat Rabbit
    Bar and Griepentrog 1967 Treon et al. 1943
    oral oral
    2,060 2,200-2,600
    ----- -----
    3,458 ppm 3,693-4,365 ppm
    346 ppm 369-437 ppm
 **Human data:** The estimated acceptable concentration for 8 hours was reported in volunteers to be less than 100 ppm [Nelson et al. 1943].
 
 **Revised IDLH:** 400 ppm **Basis for revised IDLH:** The revised IDLH for cyclohexanol is 400 ppm based on acute oral toxicity data in animals [Bar and Griepentrog 1967; Treon et al. 1943].
**REFERENCES:**
1. Bar F, Griepentrog F [1967]. Die situation in der gesundheitlichen beurteilung der aromaliscerungsmittel für lebensmittel. Med Ernahr *8*:282-251. [From ACGIH [1991]. Cyclohexanol. In: Documentation of the threshold limit values and biological exposure indices. 6th ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 357-358.]
2. Browning E [1965]. Toxicity and metabolism of industrial solvents. New York, NY: Elsevier Publishing Company, p. 387.
3. Nelson KW, Ege JF, Ross M, Woodman LE, Silverman L [1943]. Sensory response to certain industrial solvent vapors. J Ind Hyg Toxicol *25*(7):282-285.
4. Treon JF, Crutchfield WE Jr, Kitzmiller KV [1943]. The physiological response of rabbits to cyclohexane, methyl cyclohexane, and certain derivatives of these compounds. I. Oral administration and cutaneous application. J Ind Hyg Toxicol *25*(6):199-214.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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