Exhibit
4.1


 


Description
of the Registrant’s Securities Registered Pursuant to Section 12 of the Securities Exchange Act of 1934


 


Lixte
Biotechnology Holdings, Inc. (“Lixte,” “we,” “our,” and “us”) has one class of
securities registered under Section 12 of the Securities Exchange Act of 1934, as amended: our common stock, par value $0.0001
per share (the “common stock”).


 


The
following description of our common stock and preferred stock is a summary and does not purport to be complete. It is subject
to and qualified in its entirety by reference to (1) our Certificate of Incorporation, as amended, (the “Certificate of
Incorporation”) filed as Exhibits to the Registration Statement on Form 10-SB on August 3, 2005 and to our Information Statement
on September 30, 2006, (2) our Bylaws (the “Bylaws”) filed as an exhibit to our Registration Statement on Form 10-SB
on August 3, 2005, and (3) our Certificate of Designations of Series A Preferred Stock (the “Certificate of Designations”),
filed as an exhibit to our Current Report on Form 8-K on March 18, 2015, each of which is filed as an exhibit to our Annual Report
on Form 10-K of which this Exhibit 4.1 is a part. We encourage you to read the Certificate of Incorporation, the Bylaws, and the
Certificate of Designations, as well as the applicable provisions of the Delaware General Corporation Law (the “DGCL”),
for additional information.


 


Authorized
Capital Stock


 


Our
authorized capital stock consists of 100,000,000 shares of common stock and 10,000,000 shares of preferred stock, par value $0.0001
per share (the “Preferred Stock”). As of December 31, 2019, 67,045,814 shares of our common stock were issued and
outstanding, and 350,000 shares of our Series A Convertible Preferred Stock, Stated Value $10,000 per share were issued and oustanding,
all of which are fully paid and nonassessable.


 


Common
Stock


 


Voting
Rights


 


Holders
of our common stock are entitled to one vote for each share held on all matters submitted to a vote of stockholders and do not
have cumulative voting rights. An election of directors by our stockholders will be determined by a plurality of the votes cast
by the stockholders entitled to vote on the election.


 


Dividend
Rights


 


Holders
of common stock are entitled to receive proportionately any dividends that may be declared by our Board of Directors, subject
to any preferential dividend rights of any series of preferred stock that we may designate and issue.


 


Liquidation
Rights


 


In
the event of our liquidation or dissolution, the holders of common stock are entitled to receive proportionately our net assets
available for distribution to stockholders after the payment of all debts and other liabilities and subject to the preferential
rights of any outstanding preferred stock.


 




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Absence
of Other Rights


 


Holders
of our common stock have no preemptive, subscription, redemption, or conversion rights. The rights, preferences, and privileges
of holders of common stock are subject to and may be adversely affected by the rights of the holders of shares of any series of
preferred stock that we may designate and issue.


 


Preferred
Stock


 


Under
our Certificate of Incorporation, our Board of Directors has the authority, without further action by stockholders, to designate
one or more series of preferred stock and to fix the voting powers, designations, preferences, limitations, restrictions, and
relative rights granted to or imposed upon the preferred stock, including dividend rights, conversion rights, voting rights, rights
and terms of redemption, liquidation preference, and sinking fund terms, any or all of which may be preferential to or greater
than the rights of the common stock.


 


The
authority possessed by our Board of Directors to issue preferred stock could potentially be used to discourage attempts by third
parties to obtain control of our company through a merger, tender offer, proxy contest, or otherwise by making such attempts more
difficult or more costly. Our Board of Directors may issue preferred stock with voting rights, conversion rights, and other rights
that, if exercised, could adversely affect the voting power of the holders of common stock.


 


On
March 17, 2015, we filed a Certificate of Designations of our Series A Convertible Preferred Stock with the Delaware Secretary
of State to amend the Company’s Certificate of Incorporation. The Company has designated a total of 350,000 shares as Series
A Convertible Preferred Stock, which are non-voting and are not subject to increase without the written consent of a majority
of the holders of the Series A Convertible Preferred Stock or as otherwise set forth in the Certificate of Designations. The holders
of each tranche of 175,000 shares of the Series A Convertible Preferred Stock are entitled to receive a per share dividend equal
to 1% of the annual net revenue of the Company divided by 175,000, until converted or redeemed. As of December 31, 2019, 9,650,000
shares of preferred stock were undesignated and may be issued with such rights and powers as the Board of Directors may designate.


 


Each
share of Series A Convertible Preferred Stock may be converted, at the option of the holder, into 12.5 shares of common stock
(subject to customary anti-dilution provisions) and the Series A Convertible Preferred Stock is subject to mandatory conversion
at the conversion rate in the event of a merger or sale transaction resulting in gross proceeds to the Company of at least $21,875,000.
The Series A Convertible Preferred Stock has a liquidation preference based on its assumed conversion into shares of common stock.
The Series A Convertible Preferred Stock does not have a cash liquidation preference.


 


If
fully converted, the 350,000 outstanding shares of Series A Convertible Preferred Stock would convert into 4,375,000 shares of
common stock at December 31, 2019. The Company has the right to redeem the Series A Convertible Preferred Stock up to the fifth
anniversary of their respective closing dates (March 17, 2015 and January 21, 2016) at a price per share equal to $50.00. The
Series A Convertible Preferred Stock has no right to cash, except with respect to the payment of aforementioned dividend based
on the generation of revenues by the Company, and does not have any registration rights.


 




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Anti-Takeover
Effects of Our Certificate of Incorporation and Bylaws


 


Certain
provisions of our Certificate of Incorporation and Bylaws contain provisions that could have the effect of delaying or discouraging
another party from acquiring control of us. These provisions, which are summarized below, are expected to discourage certain types
of coercive takeover practices and inadequate takeover bids.


 


Our
Certificate of Incorporation and Bylaws include provisions that:


 


		●	authorize
    our Board of Directors to issue, without further action by the stockholders, up to 10,000,000 shares of preferred stock in
    one or more series designated by the Board of Directors;
	 	 	 
		●	specify
    that meetings of our stockholders can be called only by our Board of Directors, or any officer instructed by the director
    to call the meeting;
	 	 	 
		●	provide
    that vacancies on our Board of Directors may be filled by a majority of directors then in office, even though less than a
    quorum;


 


Delaware
Anti-Takeover Statute


 


We
are subject to the provisions of Section 203 of the DGCL regulating corporate takeovers. In general, Section 203 prohibits a publicly-held
Delaware corporation such as Lixte from engaging in a “business combination” with an “interested stockholder”
for a period of three years following the date the person became an interested stockholder unless:


 


	 	●	prior
    to the date of the transaction, the board of directors of the corporation approved either the business combination or the
    transaction which resulted in the stockholder becoming an interested stockholder;
	 	 	 
	 	●	upon
    completion of the transaction that resulted in the stockholder becoming an interested stockholder, the interested stockholder
    owned at least 85% of the voting stock of the corporation outstanding at the time the transaction commenced, excluding for
    purposes of determining the voting stock outstanding, but not for determining the outstanding voting stock owned by the interested
    stockholder, (1) shares owned by persons who are directors and also officers of the corporation and (2) shares owned by employee
    stock plans in which employee participants do not have the right to determine confidentially whether shares held subject to
    the plan will be tendered in a tender or exchange offer; or
	 	 	 
	 	●	at
    or subsequent to the date of the transaction, the business combination is approved by the board of directors of the corporation
    and authorized at an annual or special meeting of stockholders, and not by written consent, by the affirmative vote of at
    least 66-2/3% of the outstanding voting stock which is not owned by the interested stockholder.


 


In
this context, a “business combination” includes a merger, asset or stock sale, or other transaction resulting in a
financial benefit to the interested stockholder. An “interested stockholder” is a person who, together with affiliates
and associates, owns or, within three years prior to the determination of interested stockholder status, did own 15% or more of
a corporation’s outstanding voting stock. We expect the existence of this provision to have an anti-takeover effect with
respect to transactions our Board of Directors does not approve in advance. We also anticipate that Section 203 may discourage
business combinations or other attempts that might result in a premium over the market price for the shares of common stock held
by our stockholders.


 




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