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Ethylenediamine																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 107–15–3
**NIOSH REL:** 10 ppm (25 mg/m3) TWA
**Current OSHA PEL:** 10 ppm (25 mg/m3) TWA
**1989 OSHA PEL:** Same as current PEL
**1993-1994 ACGIH TLV:** 10 ppm (25 mg/m3) TWA [skin]
**Description of Substance:** Colorless, viscous liquid with an ammonia-like odor.
**LEL**(@12 F): 2.5% (10% LEL(@12 F), 2,500 ppm)
**Original (SCP) IDLH:** 2,000 ppm
**Basis for original (SCP) IDLH:** The chosen IDLH is based on the statement by AIHA [1970] that an 8-hour exposure to 4,000 ppm killed 6 of 6 rats, but that an 8-hour exposure to 2,000 ppm killed 0 of 6 rats [Smyth et al. 1951]. Further support for the chosen IDLH is gained from the statement by UCC [1971] that humans will not stay in concentrations of 2,000 ppm.
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50** **(ppm)**
    **LCLo** **(ppm)**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived** **value**Rat
    Smyth et a. 1951
    LC100: 4,000
    -----
    8 hr
    10,000 ppm (2.5)
    1,000 ppm
 **Lethal dose data:**
 
 **Species**
    **Reference**
    **Route**
    **LD50** **(mg/kg)**
    **LDLo** **(mg/kg)**
    **Adjusted LD**
    **Derived value**Rat G. pigRat
    Izmerov et al. 1982 Smyth et al. 1941Smyth et al. 1951
    oral oraloral
    500 4701,160
    ----- ----------
    1,400 ppm 1,316 ppm3,248 ppm
    140 ppm 132 ppm325 ppm
 **Other animal data:** It has been reported that rats have survived an 8-hour exposure to 2,000 ppm [Smyth et al. 1951].
 **Human data:** It has been reported that workers will not stay in concentrations of 2,000 ppm [UCC 1971].
 
 **Revised IDLH:** 1,000 ppm **Basis for revised IDLH:** The revised IDLH for ethylenediamine is 1,000 ppm based on acute inhalation toxicity data in animals [Smyth et al. 1951]. This may be a conservative value due to the lack of relevant acute toxicity data for workers exposed to concentrations between 1,000 and 2,000 ppm.
**REFERENCES:**
1. AIHA [1970]. Ethylene diamine. In: Hygienic guide series. Am Ind Hyg Assoc J *31*:113-115.
2. Izmerov NF, Sanotsky IV, Sidorov KK [1982]. Toxicometric parameters of industrial toxic chemicals under single exposure. Moscow, Russia: Centre of International Projects, GKNT, p. 66.
3. Smyth HF, Seaton J, Fischer L [1941]. The single dose toxicity of some glycols and derivatives. J Ind Hyg Toxicol *23*(6):259-268.
4. Smyth HF Jr, Carpenter CP, Weil CS [1951]. Range-finding toxicity data: list IV. AMA Arch Ind Hyg Occup Med *4*:119-122.
5. UCC [1971]. Toxicology studies: ethylene diamine. New York, NY: Union Carbide Corporation.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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