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Methyl methacrylate																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 80–62–6
**NIOSH REL:** 100 ppm (410 mg/m3) TWA
**Current OSHA PEL:** 100 ppm (410 mg/m3) TWA
**1989 OSHA PEL:** Same as current PEL
**1993-1994 ACGIH TLV:** 100 ppm (410 mg/m3) TWA
**Description of substance:** Colorless liquid with an acrid, fruity odor.
**LEL:** . . . 1.7% (10% LEL, 1,700 ppm)
**Original (SCP) IDLH:** 4,000 ppm
**Basis for original (SCP) IDLH:** The chosen IDLH is based on the statement by ACGIH [1971] that 4,400 ppm was fatal to rats and rabbits in 8 hours [Deichmann 1941]. Also, Patty [1963] cited an approximate rat LC50 of 3,750 ppm [Deichmann 1941; Spealman et al. 1945].
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA:**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50** **(ppm)**
    **LCLo** **(ppm)**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived value**Rat
    Blagodatin et al. 1976
    18,750
    -----
    4 hr
    37,500 ppm (2.0)
    3,750 ppmMouse
    Blagodatin et al. 1976
    4,447
    -----
    2 hr
    7,115 ppm (1.6)
    712 ppmRat
    Deichmann 1941
    -----
    4,400
    8 hr
    11,000 ppm (2.5)
    1,100 ppmRabbit
    Deichmann 1941
    -----
    4,400
    8 hr
    11,000 ppm (2.5)
    1,100 ppmRabbit
    Deichmann 1941
    -----
    4,207
    4.5 hr
    8,751 ppm (2.08)
    875 ppmG. pig
    Deichmann 1941
    -----
    4,567
    5 hr
    9,819 ppm (2.15)
    982 ppmRat
    Deichmann 1941
    3,750
    -----
    ?
    ?
    ?Mammal
    Gig Sanit 1986
    4,808
    -----
    ?
    ?
    ?**Human data:** Workers have experienced irritation, but tolerated 200 ppm without complaint [Spealman et al. 1945]. It has also been reported that 2,300 ppm was intolerable [Coleman 1963].
 
 **Revised IDLH:** 1,000 ppm **Basis for revised IDLH:** The revised IDLH for methyl methacrylate is 1,000 ppm based on acute inhalation toxicity data in humans [Coleman 1963] and animals [Blagodatin et al. 1976; Deichmann 1941].**REFERENCES:**
1. ACGIH [1971]. Methyl methacrylate. In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 168.
2. Blagodatin VM, Smiznova ES, et al. [1976]. Substantiation of the maximum permissible concentration of methacrylic acid methyl ether in the air of the working zone. Gig Tr Prof Zabol *20*(6):5-8 (in Russian).
3. Coleman AL [1963]. Letter to the TLV Committee from State of Connecticut, Labor Department, Occupational Health Section (March 15, 1963).
4. Deichmann W [1941]. Toxicity of methyl, ethyl, and n-butyl methacrylate. J Ind Hyg Toxicol *23*:343-351.
5. Gig Sanit [1986]; *51*(5):61 (in Russian).
6. Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 1880.
7. Spealman CR, Main RJ, Haag HB, Larson PS [1945]. Monomeric methyl methacrylate. Am J Ind Med *14*(4):292-298.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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