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Ethyl butyl ketone																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 106–35–4
**NIOSH REL:** 50 ppm (230 mg/m3) TWA
**Current OSHA PEL:** 50 ppm (230 mg/m3) TWA
**1989 OSHA PEL:** Same as current PEL
**1993-1994 ACGIH TLV:** 50 ppm (234 mg/m3) TWA
**Description of Substance:** Colorless liquid with a powerful, fruity odor.
**LEL:**. . Unknown
**Original (SCP) IDLH:** 3,000 ppm
**Basis for original (SCP) IDLH:** The chosen IDLH is based on the statements by Patty [1963] and Deichmann and Gerarde [1969] that 0 rats died following a 4-hour exposure to 2,000 ppm, but 6 of 6 rats died following a 4-hour exposure to 4,000 ppm [Smyth et al. 1949].
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50** **(ppm)**
    **LCLo** **(ppm)**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived** **value**Rat
    Smyth et al. 1949
    LC100: 4,000
    -----
    4 hr
    8,000 ppm (2.0)
    800 ppm
 **Lethal dose data:**
 
 **Species**
    **Reference**
    **Route**
    **LD50** **(mg/kg)**
    **LDLo** **(mg/kg)**
    **Adjusted LD**
    **Derived value**Rat
    Smyth et al. 1949
    oral
    2,760
    -----
    4,067 ppm
    408 ppm
 **Other animal data:** It has been reported that rats survived a 4-hour exposure to 2,000 ppm [Smyth et al. 1949].
 **Human data:** None relevant for use in determining the revised IDLH.
 
 **Revised IDLH:** 1,000 ppm **Basis for revised IDLH:** The revised IDLH for ethyl butyl ketone is 1,000 ppm based on acute inhalation toxicity data in animals [Smyth et al. 1949].
**REFERENCE:**
1. Deichmann WB, Gerarde HW [1969]. Table 50. Toxicity of ketones. In: Toxicology of drugs and chemicals. New York, NY: Academic Press, Inc., p. 736.
2. Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 1741.
3. Smyth HF Jr, Carpenter CP, Weil CS [1949]. Range-finding toxicity data: list III. J Ind Hyg Toxicol *31*:60-62.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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