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n-Butyl glycidyl ether																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 2426–08–6
**NIOSH REL:** 5.6 ppm (30 mg/m3) 15-minute CEILING
**Current OSHA PEL:** 50 ppm (270 mg/m3) TWA
**1989 OSHA PEL:** 25 ppm (135 mg/m3) TWA
**1993-1994 ACGIH TLV:** 25 ppm (133 mg/m3) TWA
**Description of Substance:** Colorless liquid with an irritating odor.
**LEL:** . . Unknown
**Original (SCP) IDLH:** 3,500 ppm
**Basis for original (SCP) IDLH:** The chosen IDLH is based on the statement by ACGIH [1971] that the mouse 4-hour LC50 was greater than 3,500 ppm [Hine et al. 1956].
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50** **(ppm)**
    **LCLo** **(ppm)**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived** **value**Mouse Rat
    Hine et al. 1956 Hine et al. 1956
    >3,500 1,030
    ----- -----
    4 hr 8 hr
    >7,000 ppm (2.0) 2,575 ppm (2.5)
    >700 ppm 258 ppm
 **Lethal dose data:**
 
 **Species**
    **Reference**
    **Route**
    **LD50** **(mg/kg)**
    **LDLo** **(mg/kg)**
    **Adjusted LD**
    **Derived value**Mouse Rat
    Hine et al. 1956 Smyth et al. 1962
    oral oral
    1,530 2,050
    ----- -----
    1,980 ppm 2,652 ppm
    198 ppm 265 ppm
 **Human data:** None relevant for use in determining the revised IDLH.
 
 **Revised IDLH:** 250 ppm **Basis for revised IDLH:** The revised IDLH for n-butyl glycidyl ether is 250 ppm based on acute inhalation toxicity data in animals [Hine et al. 1956]. This may be a conservative value due to the lack of relevant acute toxicity data for workers.
**REFERENCES:**
1. ACGIH [1971]. n-Butyl glycidyl ether (BGE). In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 33.
2. Hine CH, Kodama JK, Wellington JS, Dunlap MK, Anderson HH [1956]. The toxicology of glycidol and some glycidyl ethers. AMA Arch Ind Health *14*:250-264.
3. Smyth HF Jr, Carpenter CP, Weil CS, Pozzani UC, Striegel JA [1962]. Range-finding toxicity data: list VI. Am Ind Hyg Assoc J *23*:95-107.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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