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Cyclohexanone																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 108–94–1
**NIOSH REL:** 25 ppm (100 mg/m3) TWA [skin]
**Current OSHA PEL:** 50 ppm (200 mg/m3) TWA
**1989 OSHA PEL:** 25 ppm (100 mg/m3) TWA [skin]
**1993-1994 ACGIH TLV:** 25 ppm (100 mg/m3) TWA [skin]
**Description of Substance:** Water-white to pale-yellow liquid with a peppermint- or acetone-like odor.
**LEL**(@212 F): 1.1% (10% LEL(@212 F), 1,100 ppm)
**Original (SCP) IDLH:** 5,000 ppm
**Basis for original (SCP) IDLH:** The chosen IDLH is based on the statement by AIHA [1965] that a 4-hour exposure of rats to 4,000 ppm did not produce death but 8,000 ppm caused anesthesia and death [Smyth 1956]. In addition, Patty [1963] reported that typical narcotic symptoms have been observed in guinea pigs exposed for 6 hours to 4,000 ppm [Specht et al. 1940].
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50** **(ppm)**
    **LCLo** **(ppm)**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived** **value**Mouse RatRat
    Gupta et al. 1979 NPIRI 1974Smyth 1956
    ----- 8,000LC100: 4,000
    4,706 ----------
    1.5 hr 4 hr4 hr
    6,776 ppm (1.44) 16,000 ppm (2.0)8,000 ppm (2.0)
    678 ppm 1,600 ppm800 ppm
 **Other animal data:** RD50 (mouse), 756 ppm [DeCeaurriz et al. 1981].
 **Human data:** It has been reported that exposure to 75 ppm for 3 to 5 minutes has resulted in pronounced irritation of the eyes, nose, and throat [Nelson et al. 1943].
 
 **Revised IDLH:** 700 ppm **Basis for revised IDLH:** The revised IDLH for cyclohexanone is 700 ppm based on acute inhalation toxicity data in animals [Gupta et al. 1979; Smyth 1956].
**REFERENCES:**
1. AIHA [1965]. Cyclohexanone. In: Hygienic guide series. Am Ind Hyg Assoc J *26*:630-633.
2. DeCeaurriz JC, Micillino JC, Bonnet P, Guenier JP [1981]. Sensory irritation caused by various industrial airborne chemicals. Toxicol Lett *9*:137-143.
3. Gupta PK, Lawrence WH, Turner JE, Autian J [1979]. Toxicological aspects of cyclohexanone. Toxicol Appl Pharmacol *49*:525-533.
4. Nelson KW, Ege JF Jr, Ross M, Woodman LE, Silverman L [1943]. Sensory response to certain industrial solvent vapors. J Ind Hyg Toxicol *25*(7):282-285.
5. NPIRI [1974]. Raw materials data handbook, physical and chemical properties, fire hazard and health hazard data. Vol. 1. Organic solvents. Bethlehem, PA: National Printing Ink Research Institute, p. 18.
6. Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 1767.
7. Smyth HF Jr [1956]. Improved communication: hygienic standards for daily inhalation. Am Ind Hyg Assoc Q *17*(2):129-185.
8. Specht H, Miller JW, Valaer PJ, Sayers RR [1940]. Acute response of guinea pigs to the inhalation of ketone vapors. Washington, DC: U.S. Government Printing Office, Federal Security Agency, U.S. Public Health Service, NIH Bulletin *176*:1-66.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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