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1,3-Dichloro-5,5-dimethylhydantoin																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 118–52–5
**NIOSH REL:** 0.2 mg/m3 TWA, 0.4 mg/m3 STEL
**Current OSHA PEL:** 0.2 mg/m3 TWA
**1989 OSHA PEL:** 0.2 mg/m3 TWA, 0.4 mg/m3 STEL
**1993-1994 ACGIH TLV:** 0.2 mg/m3 TWA, 0.4 mg/m3 STEL
**Description of Substance:** White powder with a chlorine-like odor.
**LEL:**. . Unknown
**Original (SCP) IDLH*:** Unknown [*Note: “Effective” IDLH = 5 mg/m3 — see discussion below.]
**Basis for original (SCP) IDLH:** Very little data are available on which to base an IDLH for 1,3-dichloro-5,5-dimethylhydantoin. For this draft technical standard, therefore, the respirators have been selected on the basis of the assigned protection factor afforded by each device up to 25 × the OSHA PEL of 0.2 mg/m3 (i.e., 5 mg/m3); only the “most protective” respirators are permitted for use in concentrations exceeding 5 mg/m3.
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50**
    **LCLo**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived** **value**Rat
    Glyco 1981
    -----
    20,000 mg/m3
    1 hr
    25,000 mg/m3 (1.25)
    2,500 mg/m3
 **Lethal dose data:**
 
 **Species**
    **Reference**
    **Route**
    **LD50** **(mg/kg)**
    **LDLo** **(mg/kg)**
    **Adjusted LD**
    **Derived value**Rat RabbitG. pig
    Kay 1961/1962 Korolev et al. 1982Korolev et al. 1982
    oral oraloral
    542 1,5201,350
    ----- ----------
    3,794 mg/m310,640 mg/m39,450 mg/m3
    379 mg/m31,064 mg/m3945 mg/m3
 **Human data:** None relevant for use in determining the revised IDLH.
 
 **Revised IDLH:** 5 mg/m3**Basis for revised IDLH:** Based on health considerations and acute oral toxicity data in animals [Kay 1961/62; Korolev et al. 1982], a value of about 500 mg/m3 would have been appropriate for 1,3-dichloro-5,5-dimethylhydantoin. However, the revised IDLH for 1,3-dichloro-5,5-dimethylhydantoin is 5 mg/m3 based on being 25 times the NIOSH REL and OSHA PEL of 0.2 mg/m3 (25 is an assigned protection factor for respirators and was used during the Standards Completion Program for deciding when the "most protective" respirators should be used for 1,3-dichloro-5,5-dimethylhydantoin).
**REFERENCES:**
1. Chrostek WJ, Cromer JW [1975]. Health hazard evaluation report HHE 73-160-206, Glyco Chemicals, Inc., Williamsport, PA. Cincinnati, OH: National Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluations, and Field Studies.
2. Glyco Chemicals [1981]. 1,3-Dichloro-5,5-dimethyl-2,4-imidazolidinedione. In: TSCA 8(e) Submission to the U.S. Environmental Protection Agency (8EHQ-0281-0382). Williamsport,PA: Glyco® Chemicals, Inc.
3. Kay JH [1961/1962]. Unpublished technical reports. Northbrook, IL: Industrial Bio-Test Laboratories. (August 28, 1961; May 1, 1962).
4. Korolev AA, Vasilenko VE, et al. [1982]. Hygienic standard of dichloantine and the product of its transforation with dimethylhydantoin in water. Gig Sanit *47*(6):76-78 (in Russian).

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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