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1,1,2,2-Tetrachloro-1,2-difluoroethane																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 76–12–0
**NIOSH REL:** 500 ppm (4,170 mg/m3) TWA
**Current OSHA PEL**: 500 ppm (4,170 mg/m3) TWA
**1989 OSHA PEL**: Same as current PEL
**1993-1994 ACGIH TLV**: 500 ppm (4,170 mg/m3) TWA
**Description of substance**: Colorless solid or liquid (above 77°F) with a slight, ether-like odor.
**LEL**: . . Noncombustible Solid/Noncombustible Liquid
**Original (SCP) IDLH:** 15,000 ppm
**Basis for original (SCP) IDLH**: The chosen IDLH is based on the statement by ACGIH [1971] that exposure to 10,000 ppm for 1.5 to 2 hours produced slight intoxication in rats but no loss of reflexes [Greenberg and Lester 1950], and on the report that a 4-hour exposure to 15,000 ppm was fatal to rats [Clayton et al. 1966].
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA:**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50** **(ppm)**
    **LCLo** **(ppm)**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived value**Rat RatMouse
    Clark & Tinston 1982 Clayton et al. 1966Izmerov et al. 1982
    20,000 15,00014,522
    ----- ----------
    15 min 4 hr2 hr
    15,800 ppm (0.79) 30,000 ppm (2.0)23,235 ppm (1.6)
    1,580 ppm 3,000 ppm2,324 ppm**Other animal data**: Rats exposed to 10,000 ppm for 1.5 to 2 hours showed slight signs of intoxication but no loss of reflexes, while 20,000 to 30,000 ppm was fatal in 1.0 to 2.5 hours [Greenberg and Lester 1950].
 **Human data**: None relevant for use in determining the revised IDLH.
 
 **Revised IDLH:** 2,000 ppm **Basis for revised IDLH:** The revised IDLH for 1,1,2,2-tetrachloro-1,2-difluoroethane is 2,000 ppm based on acute inhalation toxicity data in animals [Greenberg and Lester 1950] and to be consistent with the revised IDLH for the similar chlorofluorocarbon 1,1,1,2-tetrachloro-2,2-difluoroethane which has a revised IDLH of 2,000 ppm. This may be a conservative value due to the lack of relevant acute toxicity data for workers.**REFERENCES:**
1. ACGIH [1971]. 1,1,2,2-Tetrachloro 1,2-difluoroethane. In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 249.
2. Clark DG, Tinston DJ [1982]. Acute inhalation toxicity of some halogenated and non-halogenated hydrocarbons. Hum Toxicol *1*:239-247.
3. Clayton JW Jr, Sherman H, Morrison SD, Barnes JR, Hood DB [1966]. Toxicity studies on 1,1,2,2-tetrachloro-1,2-difluoroethane and 1,1,1,2-tetrachloro-2,2-difluoroethane. Am Ind Hyg Assoc J *27*(4):332-340.
4. Greenberg LA, Lester D [1950]. Toxicity of the tetrachlorodifluoroethanes. AMA Arch Ind Hyg Occup Med *2*:345-347.
5. Izmerov NF, Sanotsky IV, Sidorov KK [1982]. Toxicometric parameters of industrial toxic chemicals under single exposure. Moscow, Russia: Centre of International Projects, GKNT, p. 54.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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