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Diglycidyl ether																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 2238–07–5
**NIOSH REL:** 0.1 ppm (0.5 mg/m3) TWA; NIOSH considers diglycidyl ether to be a potential occupational carcinogen as defined by the OSHA carcinogen policy [29 CFR 1990].
**Current OSHA PEL:** 0.5 ppm (2.8 mg/m3) CEILING
**1989 OSHA PEL:** 0.1 ppm (0.5 mg/m3) TWA
**1993-1994 ACGIH TLV:** 0.1 ppm (0.53 mg/m3) TWA
**Description of Substance:** Colorless liquid with a strong, irritating odor.
**LEL:**. . Unknown
**Original (SCP) IDLH:** 25 ppm
**Basis for original (SCP) IDLH:** The chosen IDLH is based on the male mouse 4-hour LC50 of 30 ppm [Hine et al. 1956].
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50** **(ppm)**
    **LCLo** **(ppm)**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived** **value**Mouse MouseMouseRatRatRat
    Hine et al. 1956 Hine et al. 1961Hine et al. 1961Hine et al. 1961Hine et al. 1961Marhold 1986
    30 863020068200
    ----- -------------------------
    4 hr 4 hr8 hr4 hr8 hr4 hr
    60 ppm (2.0) 192 ppm (2.0)75 ppm (2.5)400 ppm (2.0)170 ppm (2.5)400 ppm (2.0)
    6.0 ppm 19 ppm7.5 ppm40 ppm17 ppm40 ppm
 **Human data:** None relevant for use in determining the revised IDLH.
 
 **Revised IDLH:** 10 ppm **Basis for revised IDLH:** The revised IDLH for diglycidyl ether is 10 ppm based on acute inhalation toxicity data in animals [Hine et al. 1956; Hine et al. 1961]. [Note: NIOSH recommends as part of its carcinogen policy that the "most protective" respirators be worn for diglycidyl ether at concentrations above 0.1 ppm.]
**REFERENCES:**
1. Hine CH, Kodama JK, Wellington JS, Dunlap MK, Anderson HH [1956]. The toxicology of glycidol and some glycidyl ethers. AMA Arch Ind Health *14*:250-264.
2. Hine CH, Kodama JK, Guzman RJ, Dunlap MK, Lima R, Loquvam GS [1961]. Effects of diglycidyl ether on blood of animals. Arch Environ Health *2*(1):37/31-50/44.
3. Marhold J [1986]. Prehled Prumyslove Toxikologie, Organicke Latky. Prague, Czechoslovakia: Avicenum, p. 773 (in Czechoslovakian).

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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