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p-Nitrochlorobenzene																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 100–00–5
**NIOSH REL:** None established; NIOSH considers p-nitrochlorobenzene to be a potential occupational carcinogen as defined by the OSHA carcinogen policy [29 CFR 1990] that may be absorbed through the skin.
**Current OSHA PEL:** 1 mg/m3 TWA [skin]
**1989 OSHA PEL:** Same as current PEL
**1993-1994 ACGIH TLV:** 0.64 mg/m3 (0.1 ppm) TWA [skin]
**Description of substance:** Yellow, crystalline solid with a sweet odor.
**LEL:** . . . Unknown
**Original (SCP) IDLH:** 1,000 mg/m3
**Basis for original (SCP) IDLH:** No data on acute inhalation toxicity are available on which to base an IDLH for p-nitrochlorobenzene. The chosen IDLH, therefore, is based on an analogy with nitrobenzene, which has an IDLH of 200 ppm. [Note: A concentration of 200 ppm nitrobenzene is equivalent to about 1,000 mg/m3 p-nitrochlorobenzene.]
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA:**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50**
    **LCLo**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived value**Cat
    Watrous & Schultz 1950
    164 mg/m3
    -----
    7 hr
    393 mg/m3 (2.4)
    39 mg/m3**Lethal dose data:**
 
 **Species**
    **Reference**
    **Route**
    **LD50** **(mg/kg)**
    **LDLo** **(mg/kg)**
    **Adjusted LD**
    **Derived value**Rat
    Back et al. 1972
    oral
    812
    -----
    5,684 mg/m3
    568 mg/m3Mouse
    Back et al. 1972
    oral
    1,414
    -----
    9,898 mg/m3
    990 mg/m3Mouse
    Izmerov et al. 1982
    oral
    440
    -----
    3,080 mg/m3
    308 mg/m3Rat
    Sziza & Magos 1959
    oral
    420
    -----
    2,940 mg/m3
    294 mg/m3**Other animal data:** Exposures of cats and guinea pigs to 87 mg/m3 for 8 hours/day for 6 weeks resulted in methemoglobinemia and slight anemia [Watrous and Schultz 1950].
 **Human data:** Workers exposed intermittently for 0.5 to 1 hour over many months to concentrations ranging from 7 to 400 mg/m3 (average of 90 mg/m3) had only vague complaints of tiredness, loss of appetite, headache, and afternoon fatigue [Watrous and Schultz 1950]. Because of the strong and disagreeable odor, these workers voluntarily wore respiratory protection when exposed to the higher concentrations [Watrous and Schultz 1950].
 
 **Revised IDLH:** 100 mg/m3**Basis for revised IDLH:** The revised IDLH for p-nitrochlorobenzene is 100 mg/m3 based on subchronic inhalation toxicity data in workers [Watrous and Schultz 1950] and animals [Watrous and Schultz 1950]. This may be a conservative value due to the lack of relevant acute toxicity data for workers exposed to concentrations above 100 mg/m3. [Note: NIOSH recommends as part of its carcinogen policy that the "most protective" respirators be worn for p-nitrochlorobenzene at any detectable concentration.]**REFERENCES:**
1. Back KC, Thomas AA, MacEwen JD [1972]. Reclassification of materials listed as transportation health hazards. Wright-Patterson Air Force Base, OH: 6570th Aerospace Medical Research Laboratory, Report No. TSA-20-72-3, pp. A-270 to A-271.
2. Izmerov NF, Sanotsky IV, Sidorov KK [1982]. Toxicometric parameters of industrial toxic chemicals under single exposure. Moscow, Russia: Centre of International Projects, GKNT, p. 92.
3. Sziza M, Magos I [1959]. Toxikologische untersuchung einiger in der ungarischen industrie zur anwendung gelangenden aromatischen nitroverbindungen. Arch Gewerbepath Gewerbehyg *17*:217-226 (in German).
4. Watrous RM, Schultz HN [1950]. Cyclohexylamine, p-chloronitrobenzene, 2-aminopyridine: toxic effects in industrial use. Ind Med Surg *19*:317-320.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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