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ANTU																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 86-88-4
**NIOSH REL:** 0.3 mg/m3 TWA
**Current OSHA PEL:** 0.3 mg/m3 TWA
**1989 OSHA PEL:** Same as current PEL
**1993-1994 ACGIH TLV:** 0.3 mg/m3 TWA
**Description of substance:** White crystalline or gray, odorless powder.
**LEL:** Noncombustible Solid
**Original (SCP) IDLH:** 100 mg/m3
**Basis for original (SCP) IDLH:** No useful acute inhalation toxicity data are available on which to base the IDLH for ANTU. The chosen IDLH, therefore, has been estimated from the fatal human oral dose of 1 gram given by Stolman [1969]. According to ACGIH [1971], McClosky and Smith [1945] reported that the acute oral toxicity varies greatly among different species, with rats and dogs being the most susceptible (LD50 of 30 to 50 mg/kg) and rabbits the least susceptible (LD50 of 1,000 mg/kg).
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA**
**Lethal dose data:**
Species
    Reference
    Route
    LD50(mg/kg)
    LDLo(mg/kg)
    Adjusted LD
    Derived ValueDog
    AAPCO 1966
    oral
    0.38
    -----
    2.7 mg/m3
    0.3 mg/m3Rat
    Lehman 1952
    oral
    6
    -----
    42 mg/m3
    4.2 mg/m3Monkey
    Perkow 1971/76
    oral
    4,250
    -----
    29,750 mg/m3
    2,975 mg/m3Mouse
    Yakkyoku 1977
    oral
    5
    -----
    35 mg/m3
    3.5 mg/m3**Other animal data:** It has been reported that the mean oral lethal dose is 4,000 mg/kg in monkeys and is presumably much the same in man [Gosselin et al. 1984].
 **Human data:** The fatal oral dose has been reported to be 1,000 mg [Stolman 1969]. [Note: An oral dose of 1,000 mg is equivalent to a worker being exposed to 650 mg/m3 for 30 minutes, assuming a breathing rate of 50 liters per minute and 100% absorption.]
 **Revised IDLH:** 100 mg/m3 [Unchanged]**Basis for revised IDLH:** No inhalation toxicity data are available on which to base an IDLH for ANTU. However, based on acute oral toxicity data in humans [Stolman 1969] and animals [Gosselin et al. 1984; Perkow 1971/76], the original IDLH for ANTU (100 mg/m3) is not being revised at this time.**REFERENCES:**
AAPCO [1966]. Pesticide chemicals official compendium. Topeka, KS: Association of American Pesticide Control Officials, Inc., p. 57.
ACGIH [1971]. ANTU (alpha-naphthyl-thiourea). In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 15-16.
Gosselin RE, Smith RP, Hodge HC [1984]. Clinical toxicology of commercial products. 5th ed. Section III. Baltimore, MD: Williams and Wilkins Company, pp. 40-42.
Lehman AJ [1952]. Chemicals in foods: a report to the Association of Food and Drug Officials on current developments. Part II. Pesticides. Section III. Subacute and chronic toxicity. Q Bulletin Assoc Food Drug Off U.S. *16*:47-53.
McClosky WT, Smith MI [1945]. Studies on the pharmacologic action and the pathology of alpha-naphthylthiourea (ANTU). I. Pharmacology. Public Health Rep *60*(38):1101-1113.
Perkow W [1971/76]. Wirksubstanzen der pflanzenschutz und schadlingsbekampfungsmittel. Berlin, Germany: Verlag Paul Parey (in German).
Stolman A, ed. [1969]. Progress in chemical toxicology. Vol. 4. New York, NY: Academic Press, p. 235.
Yakkyoku (Pharmacy) [1977]; *28*:329-335 (in Japanese).

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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