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Methyl Cellosolve® acetate																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 110–49–6
**NIOSH REL:** 0.1 ppm (0.5 mg/m3 TWA [skin]
**Current OSHA PEL:** 25 ppm (120 mg/m3) TWA [skin]
**1989 OSHA PEL:** Same as current PEL
**1993-1994 ACGIH TLV:** 5 ppm (24 mg/m3) TWA [skin]
**Description of substance:** Colorless liquid with a mild, ether-like odor.
**LEL:** . . 1.7% (10% LEL, 1,700 ppm)
**Original (SCP) IDLH:** 4,000 ppm
**Basis for original (SCP) IDLH:** The chosen IDLH is based on an analogy with methyl methacrylate which has an IDLH of 4,000 ppm.
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA:**
**Lethalconcentration data:**

**Species**
    **Reference**
    **LC50** **(ppm)**
    **LCLo** **(ppm)**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived value**Cat
    Flury & Wirth 1933
    -----
    1,222
    7 hr
    2,933 ppm (2.4)
    293 ppmRat
    Smyth & Carpenter 1948
    -----
    7,000
    4 hr
    14,000 ppm (2.0)
    1,400 ppm**Lethal dose data:**
 
 **Species**
    **Reference**
    **Route**
    **LD50** **(mg/kg)**
    **LDLo** **(mg/kg)**
    **Adjusted LD**
    **Derived value**Rat
    Smyth & Carpenter 1948
    oral
    3,390
    -----
    4,833 ppm
    483 ppmG. pig
    Smyth et al. 1941
    oral
    1,250
    -----
    1,782 ppm
    178 ppm**Human data:** It has been stated that methyl Cellosolve® acetate is slightly less toxic than methyl Cellosolve® [Gosselin et al. 1984].
 
 **Revised IDLH:** 200 ppm **Basis for revised IDLH:** Based on health considerations and acute inhalation toxicity data in animals [Flury and Wirth 1933; Smyth and Carpenter 1948], a value of about 1,000 ppm would have been appropriate for methyl Cellosolve® acetate. However, the revised IDLH for methyl Cellosolve® acetate is 200 ppm based on being 2,000 times the current NIOSH REL of 0.1 ppm (2,000 is an assigned protection factor for respirators; only the most reliable respirators are recommended above 2,000 times the NIOSH REL).**REFERENCES:**
1. Flury F, Wirth W [1933]. Zur toxikologie der lösungsmittel (Verschieden ester, aceton, methylalkohol). Arch Gewerbepath Gewerbehyg *5*:1-90 (in German).
2. Gosselin RF, Smith RP, Hodge HC [1984]. Clinical toxicology of commercial products. 5th ed. Baltimore, MD: Williams & Wilkins Company, p. II-183.
3. Smyth HF Jr, Carpenter CP [1948]. Further experience with the range finding test in the industrial toxicology laboratory. J Ind Hyg Toxicol *30*:63-68.
4. Smyth HF Jr, Seaton J, Fischer L [1941]. The single dose toxicity of some glycols and derivatives. J Ind Hyg Toxicol *23*:259-268.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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