Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link


Centers for Disease Control and Prevention. CDC twenty four seven. Saving Lives, Protecting People
					Search
		×
			NIOSH
			NIOSH
				All CDC
				Submit
			For a full list of topics:A-Z Index
			Advanced Search
		Advanced Search


The National Institute for Occupational Safety and Health (NIOSH)


Facebook
        Twitter
        LinkedIn
        Syndicate





Ethylene glycol dinitrate																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 628–96–6
**NIOSH REL:** 0.1 mg/m3 STEL [skin]
**Current OSHA PEL:** 0.2 ppm (1 mg/m3) CEILING [skin]
**1989 OSHA PEL:** 0.1 mg/m3 STEL [skin]
**1993-1994 ACGIH TLV:** 0.05 ppm (0.31 mg/m3) TWA [skin]
**Description of Substance:** Colorless to yellow, oily, odorless liquid.
**LEL:**. . Unknown
**Original (SCP) IDLH*:** 500 mg/m3 [*Note: “Effective” IDLH = 200 mg/m3 — see discussion below.]
**Basis for original (SCP) IDLH:** No data on acute inhalation toxicity are available on which to base the IDLH for ethylene glycol dinitrate (EGDN) and/or nitroglycerin. The chosen IDLH, therefore, is based on chronic toxicity data concerning the physiological response of animals to EGDN. According to Patty [1963], rats and guinea pigs survived 6 months of exposure to 500 mg/m3 (80 ppm) EGDN with the only effect being slight drowsiness and some Heinz body formation [Stein 1956]. Although Patty [1963] stated that EGDN is more toxic for cats and rabbits, the chosen IDLH is still probably conservative because cats given 2-hour daily exposures to 21 ppm EGDN for 1,000 days exhibited only marked blood changes [von Oettingen 1946]. However, because of the assigned protection factor afforded by each device, 2,000 × the OSHA PEL of 0.1 mg/m3 (i.e., 200 mg/m3) is the concentration above which only the “most protective” respirators are permitted.
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA**
**Animal data:** Rats and guinea pigs have survived 6 months of exposure to 500 mg/m3 with the only effect being slight drowsiness and some Heinz body formation [NIOSH 1978]. Cats given 2-hour daily exposures for 1,000 days to 133 mg/m3 exhibited only marked blood changes [von Oettingen 1946].
**Human data:** Headaches have developed in workers exposed to 0.4 to 0.67 mg/m3 for 25 minutes; all workers had decreases in blood pressure [Trainor and Jones 1966]. Ethylene glycol dinitrate and nitroglycerine are vasodilators and initial exposures result in headache, dizziness, nausea, or decreases in blood pressure; however, workers became tolerant of the vasodilatory activity after 2 to 4 days of exposure [NIOSH 1978].

**Revised IDLH:** 75 mg/m3**Basis for revised IDLH:** The revised IDLH for ethylene glycol dinitrate is 75 mg/m3 based on an analogy to nitroglycerine [NIOSH 1978] which has a revised IDLH of 75 mg/m3.
**REFERENCES:**
1. NIOSH [1978]. Criteria for a recommended standard: occupational exposure to nitroglycerine and ethylene glycol dinitrate. Cincinnati, OH: U.S. Department of Health, Education, and Welfare, Public Health Service, Center for Disease Control, National Institute for Occupational Safety and Health, DHEW (NIOSH) Publication No. 78-167.
2. Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 2094.
3. Stein W [1956]. Mechanism of action of chronic inhalation of nitroglycol. Arch Gewerbepath Gewerbehyg *15*:23-26 (translated).
4. Trainor DC, Jones RC [1966]. Headaches in explosive magazine workers. Arch Environ Health *12*:231-234.
5. von Oettingen WF [1946]. II. The nitric acid esters of monovalent and polyvalent aliphatic alcohols. Nitric acid esters of bivalent alcohols. In: The effects of aliphatic nitrous and nitric acid esters on the physiological functions with special reference to their chemical constitution. NIH Bulletin *186*:27-32.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
Pinterest
Twitter
YouTube
 NIOSH Homepage NIOSH A-Z
Workplace Safety & Health Topics
Publications and Products
Programs
Contact NIOSH


About CDC
					Contact Us
					800-232-4636
 Facebook Twitter Instagram LinkedIn Youtube Pinterest Snapchat
 CONTACT CDC
				Contact Us
							Call 800-232-4636
							Email Us
			ABOUT CDC
				About CDC
							Jobs
							Funding
			POLICIES
				Accessibility
							External Links
							Privacy
							Policies
							No Fear Act
							FOIA
							OIG
							Nondiscrimination
							Vulnerability Disclosure Policy
			CONNECT WITH US
				Facebook
								Twitter
								Instagram
								LinkedIn
							Youtube
								Pinterest
								Snapchat
								Email
			LANGUAGES
				Español
							繁體中文
							Tiếng Việt
							한국어
							Tagalog
							Русский
							العربية
							Kreyòl Ayisyen
							Français
							Polski
							Português
							Italiano
							Deutsch
							日本語
							فارسی
							English


U.S. Department of Health & Human Services
			Accessibility
			External Links
			Privacy
			Policies
			No Fear Act
			FOIA
			Nondiscrimination
			OIG
			Vulnerability Disclosure Policy
			USA.gov


Exit Notification/Disclaimer Policy Close
 Links with this icon  indicate that you are leaving the CDC website. The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website.
					Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website.
					You will be subject to the destination website's privacy policy when you follow the link.
					CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website. Website Disclaimers
 Cancel Continue