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Glycidol																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 556–52–5
**NIOSH REL:** 25 ppm (75 mg/m3) TWA
**Current OSHA PEL:** 50 ppm (150 mg/m3) TWA
**1989 OSHA PEL:** 25 ppm (75 mg/m3) TWA
**1993-1994 ACGIH TLV:** 25 ppm (76 mg/m3) TWA
**Description of Substance:** Colorless liquid.
**LEL:** . . Unknown
**Original (SCP) IDLH:** 500 ppm
**Basis for original (SCP) IDLH:** The chosen IDLH is based on the mouse 4-hour LC50 of 450 ppm and the rat 8-hour LC50 of 580 ppm [Hine et al. 1956 cited by ACGIH 1971, and Patty 1963].
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50** **(ppm)**
    **LCLo** **(ppm)**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived** **value**Mouse Rat
    Hine et al. 1956 Hine et al. 1956
    450 580
    ----- -----
    4 hr 8 hr
    900 ppm (2.0) 1,450 ppm (2.5)
    90 ppm 145 ppm
 **Other animal data:** It has been reported that rats exposed repeatedly to 400 ppm for 7 hours per day, 5 days a week for 10 weeks showed no evidence of cumulative toxicity, only very slight irritation of the eyes, and slight lacrimation and respiratory distress following the first few exposures [Hine et al. 1956].
 **Human data:** None relevant for use in determining the revised IDLH.
 
 **Revised IDLH:** 150 ppm **Basis for revised IDLH:** The revised IDLH for glycidol is 150 ppm based on acute inhalation toxicity data in animals [Hine et al. 1956].
**REFERENCES:**
1. ACGIH [1971]. Glycidol. In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 121-122.
2. Hine CH, Kodama JS, Wellington JS, Dunlap MK, Anderson HH [1956]. The toxicology of glycidol and some glycidyl ethers. AMA Arch Ind Health *14*:250-264.
3. Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 1635.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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