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Diborane																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 19287–45–7
**NIOSH REL:** 0.1 ppm (0.1 mg/m3) TWA
**Current OSHA PEL:** 0.1 ppm (0.1 mg/m3) TWA
**1989 OSHA PEL:** Same as current PEL
**1993-1994 ACGIH TLV:** 0.1 ppm (0.11 mg/m3) TWA
**Description of Substance:** Colorless gas with a repulsive, sweet odor.
**LEL:**. . 0.8% (10% LEL, 800 ppm)
**Original (SCP) IDLH:** 40 ppm
**Basis for original (SCP) IDLH:** The chosen IDLH is based on the statement by ACGIH [1971] that Jacobson and Lawson [1962] found the rat 4-hour LC50 to be 40 or 80 ppm, depending on the age or strain of rats used.
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50** **(ppm)**
    **LCLo** **(ppm)**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived value**Rat MouseRatRatDogHamster
    Adams 1964 Jacobson and Lawson 1962Jacobson and Lawson 1962Krackow 1953Kunkel et al. 1956Stumpe 1960
    40 2940- 80159-181----------
    ----- ---------------12550
    4 hr 4 hr4 hr15 min2 hr8 hr
    80 ppm (2.0) 58 ppm (2.0)80-160 ppm (2.0)126-143 ppm (0.79)200 ppm (1.6)125 ppm (2.5)
    8.0 ppm 5.8 ppm8.0 ppm13-14 ppm20 ppm13 ppm
 **Human data:** None relevant for use in determining the revised IDLH.
 
 **Revised IDLH:** 15 ppm **Basis for revised IDLH:** The revised IDLH for diborane is 15 ppm based on acute inhalation toxicity data in animals [Krackow 1953].
**REFERENCES:**
1. ACGIH [1971]. Diborane. In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 72.
2. Adams RM, ed. [1964]. Boron, metallo-boron compounds and boranes. New York, NY: John Wiley & Sons, Inc., p. 693.
3. Jacobson KH, Lawson LH [1962]. The effect of age or weight on the toxicity of diborane. Toxicol Appl Pharmacol *4*:215-219.
4. Krackow EH [1953]. Toxicity and health hazards of boron hydrides. AMA Arch Ind Hyg Occup Med *8*:335-339.
5. Kunkel AM, Murtha EF, Oikemus AH, Stabile DE, Saunders JP, Wills JH [1956]. Some pharmacologic effects of diborane. AMA Arch Ind Health *13*:346-351.
6. Stumpe AR [1960]. Toxicity of diborane in high concentrations. AMA Arch Ind Health *21*:519-524.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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