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Triorthocresyl phosphate																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 78–30–8
**NIOSH REL:** 0.1 mg/m3 TWA [skin]
**Current OSHA PEL:** 0.1 mg/m3 TWA
**1989 OSHA PEL:** 0.1 mg/m3 TWA [skin]
**1993-1994 ACGIH TLV:** 0.1 mg/m3 TWA [skin]
**Description of substance:** Colorless to pale-yellow, odorless liquid or solid (below 52°F).
**LEL:** . . Unknown
**Original (SCP) IDLH:** 40 mg/m3
**Basis for original (SCP) IDLH:** No data on acute inhalation toxicity are available on which to base an IDLH for triorthocresyl phosphate. The chosen IDLH has been estimated from oral toxicity data cited by ACGIH [1971]. ACGIH [1971] reported that serious paralysis has been produced in man by an oral dose of the order of 6 to 7 mg/kg [Patty 1963].
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA:**
**Lethal dose data:**

**Species**
    **Reference**
    **Route**
    **LD50** **(mg/kg)**
    **LDLo** **(mg/kg)**
    **Adjusted LD**
    **Derived value**Mouse
    Bleiberg &Johnson 1965
    oral
    900
    -----
    6,300 mg/m3
    630 mg/m3Rabbit
    Gross & Grosse 1932
    oral
    -----
    100
    700 mg/m3
    70 mg/m3Rat
    Veronesi et al. 1984
    oral
    1,160
    -----
    8,120 mg/m3
    812 mg/m3**Human data:** It has been reported that serious paralysis has been produced by an oral dose of about 6.6 mg/kg [Deichmann and Gerarde 1969] and that the probable lethal dose is greater than 28 mg/kg [Patty 1963]. [Note: Oral doses of 6.5 or 28 mg/kg are equivalent to a 70-kg worker being exposed to about 300 or 1,300 mg/m3, respectively, for 30 minutes, assuming a breathing rate of 50 liters per minute and 100% absorption.]
 
 **Revised IDLH:** 40 mg/m3 [Unchanged] **Basis for revised IDLH:** No inhalation toxicity data are available on which to base an IDLH for triorthocresyl phosphate. However, based on acute oral toxicity data in humans [Deichmann and Gerarde 1969; Patty 1963], the original IDLH for triorthocresyl phosphate (40 mg/m3) is not being revised at this time.**REFERENCES:**
1. ACGIH [1971]. Triorthocresyl phosphate. In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 271-272.
2. Bleiberg MJ, Johnson H [1965]. Effects of certain metabolically active drugs and oximes on tri-o-cresyl phosphate toxicity. Toxicol Appl Pharmacol *7*:227-235.
3. Deichmann WB, Gerarde HW [1969]. Tricresyl phosphates. In: Toxicology of drugs and chemicals. New York, NY: Academic Press, Inc., Inc., p. 604.
4. Gross E, Grosse A [1932]. A contribution on the toxicology of ortho-tri-cresyl-phosphates. Arch Exp Pathol Pharmakol *168*:473-514 (in German).
5. Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 1920.
6. Veronesi B, Newland D, Inman A [1984]. The effect of metabolic interference on rodent-sensitivity to tri-ortho-cresyl phosphate (TOCP). Toxicologist *4*:55 [Abstract].

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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