Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link


Centers for Disease Control and Prevention. CDC twenty four seven. Saving Lives, Protecting People
					Search
		×
			NIOSH
			NIOSH
				All CDC
				Submit
			For a full list of topics:A-Z Index
			Advanced Search
		Advanced Search


The National Institute for Occupational Safety and Health (NIOSH)


Facebook
        Twitter
        LinkedIn
        Syndicate





Diisopropylamine																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 108–18–9
**NIOSH REL:** 5 ppm (20 mg/m3) TWA [skin]
**Current OSHA PEL:** 5 ppm (20 mg/m3) TWA [skin]
**1989 OSHA PEL:** Same as current PEL
**1993-1994 ACGIH TLV:** 5 ppm (21 mg/m3) TWA [skin]
**Description of Substance:** Colorless liquid with an ammonia- or fish-like odor.
**LEL:**. . 1.1% (10% LEL, 1,100 ppm)
**Original (SCP) IDLH:** 1,000 ppm
**Basis for original (SCP) IDLH:** The chosen IDLH is based on the UCC [1971] report that a 4-hour exposure to 1,000 ppm killed 2 of 6 rats. Patty [1963] reported the same information [Smyth et al. 1954].
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50** **(ppm)**
    **LCLo** **(ppm)**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived** **value**Rat MouseRatRabbitG. pigCat
    Izmerov et al. 1982 Izmerov et al. 1982Smyth et al. 1954Treon et al. 1949Treon et al. 1949Treon et al. 1949
    1,140 1,000LC33: 1,000---------------
    ----- ----------2,2072,2072,207
    2 hr 2 hr4 hr2.5 hr80 min72 min
    1,824 ppm (1.6) 1,596 ppm (1.6)2,000 ppm (2.0)3,752 ppm (1.7)3,090 ppm (1.4)2,869 ppm (1.3)
    182 ppm 160 ppm200 ppm375 ppm309 ppm287 ppm
 **Human data:** Complaints of nausea, headache, and temporary dimness in vision were reported in workers 2 to 3 hours following several 5- to 10-minute exposures to about 176 ppm; concentrations otherwise during the workshift averaged about 24 to 48 ppm [Treon et al. 1949]
 
 **Revised IDLH:** 200 ppm **Basis for revised IDLH:** The revised IDLH for diisopropylamine is 200 ppm based on acute inhalation toxicity data in workers [Treon et al. 1949] and animals [Izmerov et al. 1982; Smyth et al. 1954].
**REFERENCES:**
1. Izmerov NF, Sanotsky IV, Sidorov KK [1982]. Toxicometric parameters of industrial toxic chemicals under single exposure. Moscow, Russia: Centre of International Projects, GKNT, p. 54.
2. Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 2044.
3. Smyth HF Jr, Carpenter CP, Weil CS, Pozzani UC [1954]. Range-finding toxicity data: list V. AMA Arch Ind Hyg Occup Med *10*:61-68.
4. Treon JF, Sigmon H, Kitzmiller KV, Heyroth FF [1949]. The physiological response of animals to respiratory exposure to the vapors of diisopropylamine. J Ind Hyg Toxicol *31*:142-145.
5. UCC [1971]. Toxicology studies: diisopropyl amine. New York, NY: Union Carbide Corporation.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
Pinterest
Twitter
YouTube
 NIOSH Homepage NIOSH A-Z
Workplace Safety & Health Topics
Publications and Products
Programs
Contact NIOSH


About CDC
					Contact Us
					800-232-4636
 Facebook Twitter Instagram LinkedIn Youtube Pinterest Snapchat
 CONTACT CDC
				Contact Us
							Call 800-232-4636
							Email Us
			ABOUT CDC
				About CDC
							Jobs
							Funding
			POLICIES
				Accessibility
							External Links
							Privacy
							Policies
							No Fear Act
							FOIA
							OIG
							Nondiscrimination
							Vulnerability Disclosure Policy
			CONNECT WITH US
				Facebook
								Twitter
								Instagram
								LinkedIn
							Youtube
								Pinterest
								Snapchat
								Email
			LANGUAGES
				Español
							繁體中文
							Tiếng Việt
							한국어
							Tagalog
							Русский
							العربية
							Kreyòl Ayisyen
							Français
							Polski
							Português
							Italiano
							Deutsch
							日本語
							فارسی
							English


U.S. Department of Health & Human Services
			Accessibility
			External Links
			Privacy
			Policies
			No Fear Act
			FOIA
			Nondiscrimination
			OIG
			Vulnerability Disclosure Policy
			USA.gov


Exit Notification/Disclaimer Policy Close
 Links with this icon  indicate that you are leaving the CDC website. The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website.
					Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website.
					You will be subject to the destination website's privacy policy when you follow the link.
					CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website. Website Disclaimers
 Cancel Continue