Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link


Centers for Disease Control and Prevention. CDC twenty four seven. Saving Lives, Protecting People
					Search
		×
			NIOSH
			NIOSH
				All CDC
				Submit
			For a full list of topics:A-Z Index
			Advanced Search
		Advanced Search


The National Institute for Occupational Safety and Health (NIOSH)


Facebook
        Twitter
        LinkedIn
        Syndicate





Pindone																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 83–26–1
**NIOSH REL:** 0.1 mg/m3 TWA
**Current OSHA PEL:** 0.1 mg/m3 TWA
**1989 OSHA PEL:** Same as current PEL
**1993-1994 ACGIH TLV:** 0.1 mg/m3 TWA
**Description of substance:** Bright-yellow powder with almost no odor.
**LEL**:. . Unknown
**Original (SCP) IDLH:** 200 mg/m3
**Basis for original (SCP) IDLH:** According to ACGIH [1971], the critical rodenticidal dosages of Pival® (pindone) and warfarin are similar. Therefore, the chosen IDLH is based on an analogy with warfarin which has an IDLH of 200 mg/m3.
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA:**
**Lethal dose data:**

**Species**
    **Reference**
    **Route**
    **LD50 (mg/kg)**
    **LDLo (mg/kg)**
    **Adjusted LD**
    **Derived value**Rat DogRabbit
    Gaines 1960 Klimmer 1971Perkow 1971/1976
    oral oraloral
    280 75150
    ----- ----------
    1,960 mg/m3525 mg/m31,050 mg/m3
    196 mg/m353 mg/m3105 mg/m3**Other animal data:** It has been reported that the critical rodenticidal dosages of Pival® (pindone) and warfarin are similar [ACGIH 1971].
 **Human data:** It has been reported that 50 to 500 mg/kg is the probable lethal oral dose [Gosselin et al. 1984]. [Note: An oral dose of 50 to 500 mg/kg is equivalent to a 70-kg worker being exposed to about 2,330 to 23,300 mg/m3 for 30 minutes, assuming a breathing rate of 50 liters per minute and 100% absorption.]
 
 **Revised IDLH:** 100 mg/m3**Basis for revised IDLH:** No inhalation toxicity data are available on which to base an IDLH for pindone. Therefore, the revised IDLH for pindone is 100 mg/m3 based on acute oral toxicity data in humans [Gosselin et al. 1984] and animals [Gaines 1960; Klimmer 1971; Perkow 1971/1976] and an analogy to warfarin [ACGIH 1971] which has a revised IDLH of 100 mg/m3.**REFERENCES:**
1. ACGIH [1971]. Pival (2-pivalyl-1,3-inandione). In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 213.
2. Gaines TB [1960]. The acute toxicity of pesticides to rats. Toxicol Appl Pharmacol *2*:88-99.
3. Gosselin RG, Smith RP, Hodge HC [1984]. Clinical toxicology of commercial products. 5th ed. Baltimore, MD: Williams & Wilkins Company, p. II-348.
4. Klimmer OR [1971]. Pflanzenschutz und schaedlingsbekaempfungsmittel: abriss einer toxikologie und therapy von vergiftungen. 2nd ed. Hattingen, Germany: Hundt-Verlag, p. 118 (in German).
5. Perkow W [1971/1976]. Wirksubstanzen der pflanzenschutz und schadlingsbekampfungsmittel. Berlin, Germany: Verlag Paul Parey, 1971-1976 (in German).

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
Pinterest
Twitter
YouTube
 NIOSH Homepage NIOSH A-Z
Workplace Safety & Health Topics
Publications and Products
Programs
Contact NIOSH


About CDC
					Contact Us
					800-232-4636
 Facebook Twitter Instagram LinkedIn Youtube Pinterest Snapchat
 CONTACT CDC
				Contact Us
							Call 800-232-4636
							Email Us
			ABOUT CDC
				About CDC
							Jobs
							Funding
			POLICIES
				Accessibility
							External Links
							Privacy
							Policies
							No Fear Act
							FOIA
							OIG
							Nondiscrimination
							Vulnerability Disclosure Policy
			CONNECT WITH US
				Facebook
								Twitter
								Instagram
								LinkedIn
							Youtube
								Pinterest
								Snapchat
								Email
			LANGUAGES
				Español
							繁體中文
							Tiếng Việt
							한국어
							Tagalog
							Русский
							العربية
							Kreyòl Ayisyen
							Français
							Polski
							Português
							Italiano
							Deutsch
							日本語
							فارسی
							English


U.S. Department of Health & Human Services
			Accessibility
			External Links
			Privacy
			Policies
			No Fear Act
			FOIA
			Nondiscrimination
			OIG
			Vulnerability Disclosure Policy
			USA.gov


Exit Notification/Disclaimer Policy Close
 Links with this icon  indicate that you are leaving the CDC website. The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website.
					Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website.
					You will be subject to the destination website's privacy policy when you follow the link.
					CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website. Website Disclaimers
 Cancel Continue