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Phenyl glycidyl ether																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 122–60–1
**NIOSH REL:** 1 ppm (6 mg/m3) 15-minute CEILING; NIOSH considers phenyl glycidyl ether to be a potential occupational carcinogen as defined by the OSHA carcinogen policy [29 CFR 1990].
**Current OSHA PEL:** 10 ppm (60 mg/m3) TWA
**1989 OSHA PEL:** 1 ppm (6 mg/m3) TWA
**1993-1994 ACGIH TLV:** 1 ppm (6.1 mg/m3) TWA
**Description of substance:** Colorless liquid.
**LEL** :. . Unknown
**Original (SCP) IDLH*:** Unknown [*Note: “Effective” IDLH = 500 ppm — see discussion below.]
**Basis for original (SCP) IDLH:** ACGIH [1971] reported that 10 rats exposed to 100 ppm phenyl glycidyl ether 7 hours/day for 50 days exhibited no immediately obvious signs of toxicity, and no deaths occurred [Hine et al. 1956]. The IDLH is unknown, but for this draft technical standard, 50  ́ the OSHA PEL of 10 ppm (i.e., 500 ppm) has been chosen as the concentration above which only the “most protective” respirators are permitted. Because of the high boiling point and low vapor pressure of phenyl glycidyl ether, high concentrations are not likely to be encountered in the industrial environment.
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA:**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50** **(ppm)**
    **LCLo** **(ppm)**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived value**Rat
    Hine et al. 1956
    >100
    -----
    8 hr
    >250 ppm (2.5)
    >25 ppmMouse
    Hine et al. 1956
    >100
    -----
    4 hr
    >200 ppm (2.0)
    >20 ppmRat
    Smyth et al. 1954
    >323
    -----
    ?
    ?
    ?**Lethal dose data:**
 
 **Species**
    **Reference**
    **Route**
    **LD50** **(mg/kg)**
    **LDLo** **(mg/kg)**
    **Adjusted LD**
    **Derived value**Rat
    Hine et al. 1956
    oral
    3,350
    -----
    4,319 ppm
    432 ppmMouse
    Hine et al. 1956
    oral
    1,400
    -----
    1,571 ppm
    157 ppmMammal
    Smyth et al. 1954
    oral
    4,260
    -----
    4,779 ppm
    478 ppm**Other animal data:** In an chronic study, rats exposed to 100 ppm for 7 hours/day for 50 days exhibited no immediately obvious signs of toxicity, and no deaths occurred [Hine et al. 1956].
 **Human data:** None relevant for use in determining the revised IDLH.
 
 **Revised IDLH:** 100 ppm **Basis for revised IDLH:** The revised IDLH for phenyl glycidyl ether is 100 ppm based on chronic inhalation toxicity data in animals [Hine et al. 1956]. This may be a conservative value due to the lack of relevant acute inhalation toxicity data for workers. [Note: NIOSH recommends as part of its carcinogen policy that the "most protective" respirators be worn for phenyl glycidyl ether at concentrations above 1 ppm.]**REFERENCES:**
1. ACGIH [1971]. Phenyl glycidyl ether (PGE). In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 206-207.
2. Hine CH, Kodama JK, Wellington JS, Dunlap MK, Anderson HH [1956]. The toxicology of glycidol and some glycidyl ethers. AMA Arch Ind Health *14*:250-264.
3. Smyth HF Jr, Carpenter CP, Weil CP, Pozzani UC [1954]. Range-finding toxicity data: list V. AMA Arch Ind Hyg Occup Med *10*:61-68.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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