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n-Propyl acetate																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 109–60–4
**NIOSH REL:** 200 ppm (840 mg/m3) TWA, 250 ppm (1,050 mg/m3) STEL
**Current OSHA PEL:** 200 ppm (840 mg/m3) TWA
**1989 OSHA PEL:** 200 ppm (840 mg/m3) TWA, 250 ppm (1,050 mg/m3) STEL
**1993-1994 ACGIH TLV:** 200 ppm (835 mg/m3) TWA, 250 ppm (1,040 mg/m3) STEL
**Description of substance:** Colorless liquid with a mild, fruity odor.
**LEL**(@100°F): 1.7% (10% LEL(@100°F), 1,700 ppm)
**Original (SCP) IDLH:** 8,000 ppm
**Basis for original (SCP) IDLH:** The chosen IDLH is based on the statement by ACGIH [1971] that a 4-hour exposure to 8,000 ppm was fatal to 4 of 6 rats [Smyth et al. 1954].
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA:**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50** **(ppm)**
    **LCLo** **(ppm)**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived value**Cat
    Flury & Wirth 1933
    -----
    8,941
    5 hr
    19,223 ppm (2.15)
    1,922 ppmRat
    Smyth et al. 1969
    LC67: 8,000
    -----
    4 hr
    16,000 ppm (2.0)
    1,600 ppm**Lethal dose data:**
 
 **Species**
    **Reference**
    **Route**
    **LD50** **(mg/kg)**
    **LDLo** **(mg/kg)**
    **Adjusted LD**
    **Derived value**Rat MouseRabbitRat
    Jenner et al. 1964 Jenner et al. 1964Munch 1972Smyth et al. 1969
    oral oraloraloral
    9,370 8,3006,6408,700
    ----- ---------------
    15,433 ppm 13,671 ppm10,936 ppm14,329 ppm
    1,543 ppm 1,367 ppm1,094 ppm1,433 ppm**Other animal data:** It has been reported that based on acute inhalation studies, n-propyl acetate appears to be more toxic than isopropyl acetate and ethyl acetate but less toxic than n-butyl acetate [ACGIH 1991].
 **Human data:** None relevant for use in determining the revised IDLH.
 
 **Revised IDLH:** 1,700 ppm **Basis for revised IDLH:** The revised IDLH for n-propyl acetate is 1,700 ppm based on acute inhalation toxicity data in animals [Flury and Wirth 1933; Smyth et al. 1969]. The revised IDLH is roughly the same as the revised IDLHs for ethyl acetate and n-butyl acetate and is also 10% of the lower explosive limit of 1.7% (which was determined at 100°F). This may be a conservative value due to the lack of relevant acute inhalation toxicity data for workers.**REFERENCES:**
1. ACGIH [1971]. n-Propyl acetate. In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 216.
2. ACGIH [1991]. n-Propyl acetate. In: Documentation of the threshold limit values and biological exposure indices. 6th ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 1300.
3. Flury F, Wirth W [1933]. Zur toxikologie der lösungsmittel. (Verschieden ester, aceton, methylalkohol.) Arch Gewerbepath Gewerbehyg *5*:1-90 (in German).
4. Jenner PM, Hagan EC, Taylor JM, Cook EL, Fitzhugh OG [1964]. Food flavourings and compounds of related structure. I. Acute oral toxicity. Food Cosmet Toxicol *2*:327-343.
5. Munch JC [1972]. Aliphatic alcohols and alkyl esters: narcotic and lethal potencies to tadpoles and to rabbits. Ind Med Surg *41*:31-33.
6. Smyth HF Jr, Carpenter CP, Weil CS, Pozzani UC [1954]. Range-finding toxicity data: list V. AMA Arch Ind Hyg Occup Med *10*:61-68.
7. Smyth HF Jr, Carpenter CP, Weil CS, Pozzani UC, Striegel JA, Nycum JS [1969]. Range-finding toxicity data: list VII. Am Ind Hyg Assoc J *30*(5):470-476.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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