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Dinitrobenzene (o-, m-, p-isomers)																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 528-29-0 (o-isomer), 99–65–0 (m-isomer), 100-25-4 (p-isomer)
**NIOSH REL:** 1 mg/m3 TWA [skin]
**Current OSHA PEL:** 1 mg/m3 TWA [skin]
**1989 OSHA PEL:** Same as current PEL
**1993-1994 ACGIH TLV:** 1 mg/m3 (0.15 ppm) TWA [skin]
**Description of Substance:** Pale-white or yellow solid.
**LEL:**. . Unknown
**Original (SCP) IDLH:** 200 mg/m3
**Basis for original (SCP) IDLH:** No data on acute inhalation toxicity are available on which to base an IDLH for dinitrobenzene. The chosen IDLH, therefore, has been estimated from the statement by Deichmann and Gerarde [1969] that the probable lethal oral dose for an adult is 2 grams.
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA**
**Lethal dose data:**

**Species**
    **Reference**
    **Route**
    **LD50** **(mg/kg)**
    **LDLo** **(mg/kg)**
    **Adjusted LD**
    **Derived value**p-isomerCat
    Spector 1955
    oral
    -----
    29
    203 mg/m3
    20 mg/m3m-isomerRatRabbit
    Kitchens et al. 1978Kitchens et al. 1978
    oraloral
    83-----
    -----400
    581 mg/m32,800 mg/m3
    58 mg/m3280 mg/m3
 **Human data:** The probable lethal oral dose has been reported to be 2 grams [Deichmann and Gerarde 1969]. [Note: An oral dose of 2 grams is equivalent to a worker being exposed to about 1,300 mg/m3 for 30 minutes, assuming a breathing rate of 50 liters per minute and 100% absorption.]
 
 **Revised IDLH:** 50 mg/m3**Basis for revised IDLH:** No inhalation toxicity data are available on which to base an IDLH for dinitrobenzene. Therefore, the revised IDLH for dinitrobenzene is 50 mg/m3 based on acute oral toxicity data in humans [Deichmann and Gerarde 1969].
**REFERENCES:**
1. Deichmann WB, Gerarde HW [1969]. Dinitrobenzenes. In: Toxicology of drugs and chemicals. New York, NY: Academic Press, Inc., pp. 226-227.
2. Kitchens JF, Harward WE III, Lauter DM, Wentsel RS, Valentine RS [1978]. Preliminary problem definition of 48 munitions-related chemicals. Vol. 1. Explosives related chemicals. Alexandria, VA: Atlantic Research Corporation, U.S. Army Medical Research and Development Command Contract No. DAMD17-77-C-7057.
3. Spector WS, ed. [1955]. Handbook of toxicology. Vol. 1. Acute toxicities of solids, liquids and gases to laboratory animals. Philadelphia, PA: W.B. Saunders Co., pp. 116-117.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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