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5-Methyl-3-heptanone																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 541–85–5
**NIOSH REL:** 25 ppm (130 mg/m3) TWA
**Current OSHA PEL:** 25 ppm (130 mg/m3) TWA
**1989 OSHA PEL:** Same as current PEL
**1993-1994 ACGIH TLV:** 25 ppm (131 mg/m3) TWA
**Description of substance:** Colorless liquid with a pungent odor.
**LEL:** . . Unknown
**Original (SCP) IDLH:** 3,000 ppm
**Basis for original (SCP) IDLH:** The chosen IDLH is based on the statement by Patty [1963] that 0 of 6 rats died, but 3 of 6 mice died when exposed for 4 hours to about 3,000 ppm [Shell 1958].
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA:**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50** **(ppm)**
    **LCLo** **(ppm)**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived value**Mouse
    Shell 1958
    3,000
    -----
    4 hr
    6,000 ppm (2.0)
    600 ppmRat
    Shell 1958
    LC67: 6,000
    -----
    8 hr
    15,000 ppm (2.5)
    1,500 ppmRat
    Shell 1961
    -----
    3,484
    8 hr
    8,710 ppm (2.5)
    871 ppmMouse
    Shell 1961
    -----
    3,484
    4 hr
    6,968 ppm (2.0)
    697 ppm**Other animal data:** It has been reported that rats survived a 4-hour exposure to 3,000 ppm [Shell 1958].
 **Human data:** Humans exposed to 25 ppm experienced irritation of the eyes and respiratory tract and detected a strong odor, while 100 ppm caused irritation of the mucous membranes, headache, and nausea which was too severe to tolerate for more than a few minutes [Clayton and Clayton 1981].
 
 **Revised IDLH:** 100 ppm **Basis for revised IDLH:** The revised IDLH for 5-methyl-3-heptanone is 100 ppm based on acute inhalation toxicity data in humans [Clayton and Clayton 1981].**REFERENCES:**
1. Clayton GD, Clayton FE, eds. [1981]. Patty’s industrial hygiene and toxicology. 3rd rev. ed. Vol. 2C. Toxicology. New York, NY: John Wiley & Sons, Inc., pp. 4767-4768.
2. Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 1744.
3. Shell [1958]. Toxicity data sheet: SC 57-99. Houston, TX: Shell Chemical Corporation, Industrial Hygiene Bulletin Toxicity Data Sheet.
4. Shell [1961]. Unpublished report. Houston, TX: Shell Chemical Corporation, p. 6.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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