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o-Toluidine																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 95–53–4
**NIOSH REL:** None established; NIOSH considers o-toluidine to be a potential occupational carcinogen as defined by the OSHA carcinogen policy [29 CFR 1990] that may be absorbed through the skin.
**Current OSHA PEL:** 5 ppm (22 mg/m3) TWA [skin]
**1989 OSHA PEL:** Same as current PEL
**1993-1994 ACGIH TLV:** 2 ppm (8.8 mg/m3) TWA [skin], A2
**Description of substance:** Colorless to pale-yellow liquid with an aromatic, aniline-like odor.
**LEL:** . . Unknown
**Original (SCP) IDLH:** 100 ppm
**Basis for original (SCP) IDLH:** The chosen IDLH is based on the statement by Sax [1975] that 100 ppm is the maximum concentration endurable for 1 hour without serious consequences. No other data are available on which to base the IDLH.
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA:**
**Lethal dose data:**

**Species**
    **Reference**
    **Route**
    **LD50** **(mg/kg)**
    **LDLo** **(mg/kg)**
    **Adjusted LD**
    **Derived value**Rat MouseRabbitRatRat
    IARC 1982 IARC 1982IARC 1982Jacobsen 1972Jacobsen 1972
    oral oraloraloraloral
    670 520840900940
    ----- --------------------
    1,052 ppm 816 ppm1,318 ppm1,413 ppm1,475 ppm
    105 ppm 82 ppm132 ppm141 ppm148 ppm**Other animal data:** Rats have survived an 8-hour exposure to saturated vapors of o-toluidine [Smyth et al. 1962].
 **Human data:** It has been reported that a 60-minute exposure to 40 ppm produces severe toxic effects [Goldblatt 1955]. It has been reported that 100 ppm is the maximum concentration endurable for 1 hour without serious consequences [Sax 1975].
 
 **Revised IDLH:** 50 ppm **Basis for revised IDLH:** The revised IDLH for o-toluidine is 50 ppm based on acute inhalation toxicity data in humans [Goldblatt 1955; Sax 1975]. [Note: NIOSH recommends as part of its carcinogen policy that the "most protective" respirators be worn for o-toluidine at any detectable concentration.]**REFERENCES:**
1. Goldblatt MW [1955]. Research in industrial health in the chemical industry. Brit J Ind Med 12:1-20.
2. IARC [1982]. ortho-Toluidine and its hydrochloride. In: IARC monographs on the evaluation of carcinogenic risk of chemicals to humans. Vol. 27. Some aromatic amines, anthraquinones and nitroso compounds, and inorganic fluorides used in drinking-water and dental preparations, pp. 155-175.
3. Jacobsen KH [1972]. Short communication: acute oral toxicity of mono- and di-alkyl ring-substituted derivatives of aniline. Toxicol Appl Pharmacol 22:153-154.
4. Sax NI [1975]. o-Toluidine. In: Dangerous properties of industrial materials. 4th ed. New York, NY: Van Nostrand Reinhold Company, pp. 1173-1176.
5. Smyth HF, Carpenter CP, Weil CS, Pozzani UC, Striegel JA [1962]. Range-finding toxicity data: list VI. Am Ind Hyg Assoc J 23:95-107.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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