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Acetylene tetrabromide																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 79-27-6
**NIOSH REL:** The 1989 OSHA PEL may not be protective to workers.
**Current OSHA PEL:** 1 ppm (14 mg/m3) TWA
**1989 OSHA PEL:** Same as current PEL
**1993-1994 ACGIH TLV:** 1 ppm (14 mg/m3) TWA
**Description of substance:** Pale-yellow liquid with a pungent odor similar to camphor or iodoform.
**LEL:** Noncombustible Liquid
**Original (SCP) IDLH:** 10 ppm
**Basis for original (SCP) IDLH:** Van Haaften [1969] reported that a chemist who had been exposed to 1 to 2 ppm for 7.5 hours, with only a single 10-minute exposure at 16 ppm, almost died from liver damage. Because the TLV is 1 ppm [ACGIH 1976], it is assumed that exposure to 1 to 2 ppm would be a safe concentration for the 7.5 hours the worker was exposed. Therefore, the injury must have been produced by the 10-minute exposure to 16 ppm, and the IDLH would be expected to fall between 2 ppm and 15 ppm. For this draft technical standard, an IDLH of 10 ppm is assumed. This is an extremely toxic substance.
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA**
**Lethal concentration data:**
Species
    Reference
    LC50(ppm)
    LCLo(ppm)
    Time
    Adjusted
    0.5-hr LC (CF)
    Derived ValueRat
    Izmerov et al. 1982
    38
    -----
    4 hr
    76 ppm
    (2.0)
    7.6 ppm**Lethal dose data:**
 Species
    Reference
    Route
    LD50(mg/kg)
    LDLo(mg/kg)
    Adjusted LD
    Derived ValueG. pig
    Gray 1950
    oral
    400
    -----
    195 ppm
    20 ppmRabbit
    Gray 1950
    oral
    400
    -----
    195 ppm
    20 ppmMouse
    Izmerov et al.1982
    oral
    269
    -----
    131 ppm
    13 ppmRat
    Paustovskaya et al. 1967
    oral
    1,200
    -----
    585 ppm
    59 ppm**Human data:** Severe acute intoxication was reported in a chemist after exposure to 16 ppm for about 10 minutes and to 1 to 2 ppm for most of the day [Van Haaften 1969].
 **Revised IDLH:** 8 ppm**Basis for revised IDLH:** The revised IDLH for acetylene tetrabromide is 8 ppm based on acute inhalation toxicity data in animals [Izmerov et al. 1982].**REFERENCES:**
ACGIH [1976]. TLVs, Threshold limit values for chemical substances and physical agents in the workroom environment with intended changes for 1976. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 9.
Gray MG [1950]. Effect of exposure to the vapors of tetrabromoethane (acetylene tetrabromide). AMA Arch Ind Hyg Occup Med *2*:407-419.
Izmerov NF, Sanotsky IV, Sidorov KK [1982]. Toxicometric parameters of industrial toxic chemicals under single exposure. Moscow, Russia: Centre of International Projects, GKNT, p. 107.
Paustovskaya VV, et al. [1967]. Effect of tetrabromomethane on the parenchymatous organs in experimental conditions. Med Pr *3*:80-83 (in Polish).
Van Haaften AB [1969]. Acute tetrabromoethane (acetylene tetrabromide) intoxication in man. Am Ind Hyg Assoc J *30*:251-256.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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