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Dichloromonofluoromethane																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 75–43–4
**NIOSH REL:** 10 ppm (40 mg/m3) TWA
**Current OSHA PEL:** 1,000 ppm (4,200 mg/m3) TWA
**1989 OSHA PEL:** 10 ppm (40 mg/m3) TWA
**1993-1994 ACGIH TLV:** 10 ppm (42 mg/m3) TWA
**Description of Substance:** Colorless gas with a slight, ether-like odor.
**LEL:**. . Nonflammable Gas
**Original (SCP) IDLH:** 50,000 ppm
**Basis for original (SCP) IDLH:** ACGIH [1971] reported that 52,000 ppm produced incoordination, irregular breathing, and tremors in guinea pigs [Underwriters’ Laboratory 1935]. Scheel (member of the Standards Completion Program Respirator Committee), in evaluating the work of Aviado and Belej [1974], indicated cardiac toxicity at 100,000 ppm. Based on the above data, an IDLH of 50,000 ppm has been chosen.
**Existing short-term exposure guidelines:** National Research Council [NRC 1984] Emergency Exposure Guidance Levels (EEGLs):
1-hour EEGL: 100 ppm
24-hour EEGL: 3 ppm
**ACUTE TOXICITY DATA**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50**
    **LCLo**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived** **value**Mouse RatG. pigMouse
    Kozbakova 1976 Tappan and Waritz 1964von Weigand 1971von Weigand 1971
    >800,000 mg/m3 49,900 ppm----------
    ----- -----100,000 ppm100,000 ppm
    2 hr 4 hr<1 hr<1 hr
    >373,832 ppm (2.0) 99,800 ppm (2.0)<125,000 ppm (1.25)<125,000 ppm (1.25)
    >37,383 ppm 9,980 ppm<12,500 ppm<12,500 ppm
 **Other animal data:** In 5-minute cardiac sensitization screening tests, 2 of 12 unanesthetized dogs exposed to 10,000 ppm of dichloromonofluoromethane plus intravenous epinephrine showed evidence of serious arrhythmia; no response was noted at 5,000 ppm [Mullin 1975].
 **Human data:** None relevant for use in determining the revised IDLH.
 
 **Revised IDLH:** 5,000 ppm **Basis for revised IDLH:** The revised IDLH for dichloromonofluoromethane is 5,000 ppm based on acute inhalation toxicity data in animals [Mullin 1975; Tappan and Waritz 1964; von Weigand 1971]. This may be a conservative value due to the lack of relevant acute toxicity data for workers.
**REFERENCES:**
1. ACGIH [1971]. Dichloromonofluoromethane. In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 81-82.
2. Aviado DM, Belej MA [1974]. Toxicity of aerosol propellants on the respiratory and circulatory systems. I. Cardiac arrythmia in the mouse. Toxicology *2*:31-42.
3. Kozbakova AE [1976]. Comparative toxicity of chlorinated and fluorinated methane and ethane derivatives. Gig Tr Prof Zabol *20*(11):38-41 (in Russian).
4. Mullin LS [1975]. Unpublished data. Newark, DE: Haskell Laboratory, E.I. DuPont de Nemours and Company, November 1975. [From ACGIH [1991]. Dichlorofluoromethane. In: Documentation of the threshold limit values and biological exposure indices. 6th ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 434-435.]
5. NRC [1984]. Emergency and continuous exposure limits for selected airborne contaminants. Vol. 2. Washington, DC: National Academy Press, Committee on Toxicology, Board on Toxicology and Environmental Health Hazards, Commission on Life Sciences, National Research Council, pp. 41-45.
6. Tappan CH, Waritz RS [1964]. Unpublished data: acute inhalation toxicity of Freon-21® (fluorodichloromethane). Report No. 128-64. Newark, DE: E.I. DuPont de Nemours and Company, Haskell Laboratory for Toxicology and Industrial Medicine, November 1964.
7. Underwriters’ Laboratory [1935]. The comparative life, fire, and explosion hazards of dichloromonofluoromethane (F21). Miscellaneous Hazard Report No. 2630. [From ACGIH [1971]. Dichloromonofluoromethane. In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 81-82.]
8. von Weigand W [1971]. Investigations on the inhalation toxicity of fluorine derivatives of methane, ethane, and cyclobutane. Zentralbl Arbeitsmed Arbeitsschutz *21*:149-156 (in German).

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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