Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link


Centers for Disease Control and Prevention. CDC twenty four seven. Saving Lives, Protecting People
					Search
		×
			NIOSH
			NIOSH
				All CDC
				Submit
			For a full list of topics:A-Z Index
			Advanced Search
		Advanced Search


The National Institute for Occupational Safety and Health (NIOSH)


Facebook
        Twitter
        LinkedIn
        Syndicate





2,4,5-T																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number**: 93-76-5
**NIOSH REL**: 10 mg/m3 TWA
**Current OSHA PEL**: 10 mg/m3 TWA
**1989 OSHA PEL**: Same as current PEL
**1993-1994 ACGIH TLV**: 10 mg/m3 TWA
**Description of substance**: Colorless to tan, odorless, crystalline solid.
**LEL** :. . Unknown
**Original (SCP) IDLH*:** Unknown [*Note: “Effective” IDLH = 5,000 mg/m3 — see discussion below.]
**Basis for original (SCP) IDLH**: According to ACGIH [1971], “the toxicity of this compound appears to be similar to the somewhat better known 2,4-D. According to Rowe and Hymas [1954], the oral LD50 values fall in a range of 300 to 1,000 mg/kg for rats, mice, guinea pigs, and rabbits. Chronic exposure is not necessarily more hazardous. Drill and Hiratzka [1953] found that there were no deaths among dogs treated with 2, 5, or 10 mg/kg/day of 2,4,5-T (5 days/week for 13 weeks); some deaths occurred at 20 mg/kg/day. There are no reports of illness from occupational exposure. It appears that the TLV of 10 mg/m3 is justified on the basis of extrapolation from animal feeding studies and extensive use experience.” Based on the toxicological data cited above, 2,4,5-T is a relatively nontoxic compound. Because data on acute inhalation toxicology are not available for this substance and to be consistent with the IDLHs selected for similar, relatively nontoxic compounds, 5,000 mg/m3 (i.e., 500  ́ the OSHA PEL of 10 mg/m3) has been chosen as the concentration above which only the “most protective” respirators are permitted.
**Short-term exposure guidelines**: None developed
**ACUTE TOXICITY DATA**:
**Lethal dose data**:

**Species**
    **Reference**
    **Route**
    **LD50** **(mg/kg)**
    **LDLo** **(mg/kg)**
    **Adjusted LD**
    **Derived value**G. pig
    AAPCO 1966
    oral
    381
    -----
    2,667 mg/m3
    267 mg/m3Rat
    Bailey & White 1965
    oral
    300
    -----
    2,100 mg/m3
    210 mg/m3Hamster
    Grant 1979
    oral
    425
    -----
    2,975 mg/m3
    298 mg/m3Mouse
    Senczuk & Pogorzelska 1980
    oral
    242
    -----
    1,694 mg/m3
    169 mg/m3**Other animal data**: It has been reported that there were no deaths among dogs treated with 2, 5, or 10 mg/kg/day of 2,4,5-T (5 days/week for 13 weeks); some deaths occurred at 20 mg/kg/day [Drill and Hiratzka 1953].
 **Human data:** None relevant for use in determining the revised IDLH.
 
 **Revised IDLH:** 250 mg/m3 **Basis for revised IDLH:** No inhalation toxicity data are available on which to base an IDLH for 2,4,5-T. Therefore, the revised IDLH for 2,4,5-T is 250 mg/m3 based on acute oral toxicity data in animals [AAPCO 1966; Bailey and White 1965; Grant 1979; Senczuk and Pogorzelska 1980]. This may be a conservative value due to the lack of relevant acute inhalation toxicity data for workers.**REFERENCES**:
1. AAPCO [1966]. Pesticide chemicals official compendium. Topeka, KS: Association of American Pesticide Control Officials, Inc., p. 965.
2. ACGIH [1971]. 2,4,5-T (2,4,5 trichlorophenoxyacetic acid). In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 242.
3. Bailey GW, White JL [1965]. Herbicides: a compilation of their physical, chemical, and biological properties. Residue Reviews 10:97-102.
4. Drill VA, Hiratzka T [1953]. Toxicity of 2,4-dichlorophenoxyacetic acid and 2,4,5-trichloro-phenoxyacetic acid. AMA Arch Ind Hyg Occup Med 7:61-67.
5. Grant WF [1979]. The genotoxic effects of 2,4,5-T. Mutat Res 65:83-110.
6. Rowe VK, Hymas TA [1954]. Summary of toxicological information on 2,4-D and 2,4,5-T type herbicides and an evaluation of the hazards to livestock associated with their use. Am J Vet Res 15(57):622-629.
7. Senczuk W, Pogorzelska H [1980]. Budowa chemiczna a toksykodynamiczne wlasciwosci pochodnych kwasow fenoksykarboksylowych. Roczniki Panstwowego Zakladu Higieny 31(4):373-377 (in Polish).

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
Pinterest
Twitter
YouTube
 NIOSH Homepage NIOSH A-Z
Workplace Safety & Health Topics
Publications and Products
Programs
Contact NIOSH


About CDC
					Contact Us
					800-232-4636
 Facebook Twitter Instagram LinkedIn Youtube Pinterest Snapchat
 CONTACT CDC
				Contact Us
							Call 800-232-4636
							Email Us
			ABOUT CDC
				About CDC
							Jobs
							Funding
			POLICIES
				Accessibility
							External Links
							Privacy
							Policies
							No Fear Act
							FOIA
							OIG
							Nondiscrimination
							Vulnerability Disclosure Policy
			CONNECT WITH US
				Facebook
								Twitter
								Instagram
								LinkedIn
							Youtube
								Pinterest
								Snapchat
								Email
			LANGUAGES
				Español
							繁體中文
							Tiếng Việt
							한국어
							Tagalog
							Русский
							العربية
							Kreyòl Ayisyen
							Français
							Polski
							Português
							Italiano
							Deutsch
							日本語
							فارسی
							English


U.S. Department of Health & Human Services
			Accessibility
			External Links
			Privacy
			Policies
			No Fear Act
			FOIA
			Nondiscrimination
			OIG
			Vulnerability Disclosure Policy
			USA.gov


Exit Notification/Disclaimer Policy Close
 Links with this icon  indicate that you are leaving the CDC website. The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website.
					Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website.
					You will be subject to the destination website's privacy policy when you follow the link.
					CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website. Website Disclaimers
 Cancel Continue