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Methyl (n-amyl) ketone																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 110–43–0
**NIOSH REL:** 100 ppm (465 mg/m3) TWA
**Current OSHA PEL:** 100 ppm (465 mg/m3) TWA
**1989 OSHA PEL:** Same as current PEL
**1993-1994 ACGIH TLV:** 50 ppm (233 mg/m3) TWA
**Description of substance:** Colorless to white liquid with a banana-like, fruity odor.
**LEL**(@151°F): 1.1% (10% LEL(@151°F), 1,100 ppm)
**Original (SCP) IDLH:** 4,000 ppm
**Basis for original (SCP) IDLH:** The chosen IDLH is based on the statement by Patty [1963] that 2,000 ppm was strongly narcotic and 4,800 ppm caused narcosis and death in guinea pigs in 4 to 8 hours [Specht et al. 1940].
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA:**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50** **(ppm)**
    **LCLo** **(ppm)**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived value**Rat
    Clayton & Clayton 1981
    -----
    4,000
    4 hr
    8,000 ppm (2.0)
    800 ppmG. pig
    Specht et al. 1940
    -----
    2,000
    14.8 hr
    6,180 ppm (3.09)
    618 ppm**Lethal dose data:**
 
 **Species**
    **Reference**
    **Route**
    **LD50** **(mg/kg)**
    **LDLo** **(mg/kg)**
    **Adjusted LD**
    **Derived value**Rat
    Smyth et al. 1962
    oral
    1,670
    -----
    2,461 ppm
    246 ppmMouse
    Srepel & Akacic 1962
    oral
    730
    -----
    1,076 ppm
    108 ppm**Other animal data:** Exposures to guinea pigs lasting 4-8 hours were irritating to the mucous membranes at 1,500 ppm, strongly narcotic at 2,000 ppm, and caused narcosis and death at 4,800 ppm [Specht et al. 1940].
 **Human data:** None relevant for use in determining the revised IDLH.
 
 **Revised IDLH:** 800 ppm **Basis for revised IDLH:** The revised IDLH for methyl (n-amyl) ketone is 800 ppm based on acute inhalation toxicity data in animals [Clayton and Clayton 1981].**REFERENCES:**
1. Clayton GD, Clayton FE, eds. [1981]. Patty’s industrial hygiene and toxicology. 3rd rev. ed. Vol. 2C. Toxicology. New York, NY: John Wiley & Sons, Inc., p. 4757.
2. Patty FA, ed. [1063]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 1740.
3. Smyth HF Jr, Carpenter CP, Weil CS, Pozzani UC, Striegel JA [1962]. Range-finding toxicity data: list VI. Am Ind Hyg Assoc J *23*:95-107.
4. Specht H, Miller JW, Valaer PJ, Sayers RR [1940]. Acute response of guinea pigs to the inhalation of ketone vapors. NIH Bulletin *176*:1-66.
5. Srepel B, Akacic B [1962]. Ispitivanje anthelminti_kog djelovanja eteri_nih ulja roda Ruta. Acta Pharmaceut Jugo *12*:79-86 (in Serbo-Croatian).

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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