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Camphor (synthetic)																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 76–22–2
**NIOSH REL:** 2 mg/m3 TWA
**Current OSHA PEL:** 2 mg/m3 TWA
**1989 OSHA PEL:** Same as current PEL
**1993-1994 ACGIH TLV:** 12 mg/m3 (2 ppm) TWA, 19 mg/m3 (3 ppm) STEL
**Description of Substance:** Colorless or white crystals with a penetrating, aromatic odor.
**LEL:** . . 0.6% (10% LEL, 3,600 mg/m3)
**Original (SCP) IDLH:** 200 mg/m3
**Basis for original (SCP) IDLH:** No data on acute inhalation toxicity are available on which to base an IDLH for camphor. For this draft technical standard, therefore, the chosen IDLH is based on a report by Gronka et al. [1969] concerning the camphor processing and packaging area of a plant. Concentrations of camphor ranging from 3 to 194 mg/m3 produced nose and sinus irritation among workers in this plant [Gronka et al. 1969].
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50**
    **LCLo**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived** **Value**Mouse
    Nikolaeva 1957
    -----
    400 mg/m3
    3 hr
    720 mg/m3 (1.8)
    72 mg/m3
 **Lethal dose data:**
 
 **Species**
    **Reference**
    **Route**
    **LD50** **(mg/kg)**
    **LDLo** **(mg/kg)**
    **Adjusted LD**
    **Derived value**Dog MouseRabbit
    Flury and Zernik 1935 Horikawa and Okada 1975Smith and Margolis 1954
    oral oraloral
    ----- 1,310-----
    800 -----2,000
    5,600 mg/m39,170 mg/m314,000 mg/m3
    560 mg/m3917 mg/m31,400 mg/m3
 **Human data:** It has been reported that concentrations during camphor processing and packaging ranged from 33 to 194 mg/m3; workers had no complaints other than slight eye irritation and afternoon drowsiness [Gronka et al. 1969].
 
 **Revised IDLH:** 200 mg/m3 [Unchanged] **Basis for revised IDLH:** Based on chronic inhalation toxicity data in workers [Gronka et al. 1969], the original IDLH for synthetic camphor (200 mg/m3) is not being revised at this time.
**REFERENCES:**
1. Flury F, Zernik F [1935]. Zusammenstellung der toxischen und letalen dosen für die gebräuchlichsten gifte und versuchstiere. Abder Hand Biol Arbeitsmethod *4*:1289-1422 (in German).
2. Gronka PA, Bobkoski RL, Tomchick GJ, Rakow AB [1969]. Camphor exposures in a packaging plant. Am Ind Hyg Assoc J *30*:276-279.
3. Horikawa E, Okada T [1975]. Experimental study on acute toxicity of phenol camphor. Shika Gakuho (Journal of Dentistry) *75*:934-939 (in Japanese).
4. Nikolaeva [1957]. Toxicological evaluation of camphor vapors. Gig Sanit *22*(11):83-86 (in Russian).
5. Smith AG, Margolis G [1954]. Camphor poisoning: anatomical and pharmacologic study; report of a fatal case; experimental investigation of protective action of barbiturate. Am J Pathol *30*(5):857-868.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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