Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link


Centers for Disease Control and Prevention. CDC twenty four seven. Saving Lives, Protecting People
					Search
		×
			NIOSH
			NIOSH
				All CDC
				Submit
			For a full list of topics:A-Z Index
			Advanced Search
		Advanced Search


The National Institute for Occupational Safety and Health (NIOSH)


Facebook
        Twitter
        LinkedIn
        Syndicate





Zinc chloride fume																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 7646–85–7
**NIOSH REL:** 1 mg/m3 TWA, 2 mg/m3 STEL
**Current OSHA PEL:** 1 mg/m3 TWA
**1989 OSHA PEL:** 1 mg/m3 TWA, 2 mg/m3 STEL
**1993-1994 ACGIH TLV:** 1 mg/m3 TWA, 2 mg/m3 STEL
**Description of substance:** White particulate dispersed in air.
**LEL:** . . Noncombustible Solid
**Original (SCP) IDLH*:** 4,800 mg/m3 [*Note: “Effective” IDLH = 2,000 mg/m3 — see discussion below.]
**Basis for original (SCP) IDLH:** The chosen IDLH is based on the 30-minute human TCLO of 4,800 mg/m3 zinc chloride [Ferry 1974 cited by NIOSH 1976]; and the toxic effects involved the respiratory system. No other data on acute inhalation toxicity are available on which to base the IDLH for zinc chloride fume. Because of the assigned protection factor afforded by each device, however, 2,000  ́ the OSHA PEL (i.e., 2,000 mg/m3) is the concentration above which only the “most protective” respirators are permitted.
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA:**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50**
    **LCLo**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived value**Rat
    Karlsson et al. 1986
    LC67: 1,960 mg/m3
    -----
    10 min
    1,352 mg/m3
    135 mg/m3Rat
    Marrs et al. 1983
    1,260 mg/m3
    -----
    30 min
    1,260 mg/m3
    126 mg/m3Rabbit
    Marrs et al. 1983
    LC70: 1,260 mg/m3
    -----
    30 min
    1,260 mg/m3
    126 mg/m3Mouse
    Marrs et al. 1983
    11,80 mg-min/m3
    -----
    -----
    393 mg/m3
    39 mg/m3**Lethal dose data:**
 
 **Species**
    **Reference**
    **Route**
    **LD50** **(mg/kg)**
    **LDLo** **(mg/kg)**
    **Adjusted LD**
    **Derived value**Rat
    Calvery 1942
    oral
    350
    -----
    2,450 mg/m3
    245 mg/m3Mouse
    Calvery 1942
    oral
    350
    -----
    2,450 mg/m3
    245 mg/m3G. pig
    Calvery 1942
    oral
    200
    -----
    1,400 mg/m3
    140 mg/m3Rat
    Domingo et al. 1988
    oral
    1,100
    -----
    7,700 mg/m3
    770 mg/m3Mouse
    Domingo et al. 1988
    oral
    1,250
    -----
    8,750 mg/m3
    875 mg/m3**Other animal data:** It has been reported that 90 mg/m3 is the no observed adverse effect level (NOEL) for rat intratracheal fibrosis [Richards et al. 1989].
 **Human data:** A 30-minute exposure to 4.8 mg/m3 has been reported to produce respiratory distress [Ferry 1974]. Exposure to 80 mg/m3 has caused nausea and coughing and 120 mg/m3 for 2 minutes has caused nose and upper respiratory system irritation [Cullumbine 1957].
 
 **Revised IDLH:** 50 mg/m3**Basis for revised IDLH:** The revised IDLH for zinc chloride fume is 50 mg/m3 based on acute toxicity data in humans [Cullumbine 1957] and animals [Richards et al. 1989].**REFERENCES:**
1. Calvery HO [1942]. Trace elements in foods. Food Res *7*:313-331.
2. Cullumbine H [1957]. The toxicity of screening smokes. J Royal Army Med Corps *103*:119-122.
3. Domingo JL, Llobet JM, Paternain JL, Corbella J [1988]. Acute zinc intoxication. Vet Hum Toxicol *30*(3):224-228.
4. Ferry JJ [1974]. Personal communication with area manager of industrial & environmental hygiene. General Electric Company, 1 River Road, Schenectady, NY 12345.
5. Karlsson N, Cassel G, Fangmark I, Bergman F [1986]. A comparative study of the acute inhalation toxicity of smoke from TiO2-hexachloroethane and Zn-hexachloroethane pyrotechnic mixtures. Arch Toxicol *59*(3):160-166.
6. Marrs TC, Clifford WE, Colgrave HF [1983]. Pathological changes produced by exposure of rabbits and rats to smokes of hexachloroethane and zinc oxide. Toxicology Lett *19*:247-252.
7. NIOSH [1976]. ZH14000. Zinc chloride. In: Registry of toxic effects of chemical substances, 1976 ed. Cincinnati, OH: U.S. Department of Health, Education, and Welfare, Public Health Service, Center for Disease Control, National Institute for Occupational Safety and Health, DHEW (NIOSH) Publication No. 76-191, p. 1228.
8. Richards RJ, Atkins J, Marrs TC, Brown RFR, Masek L [1989]. The biological and pathological changes produced by the intratracheal instillation of certain compounds of zinc-hexachloroethane smoke. Toxicology *54*(1):79-88.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
Pinterest
Twitter
YouTube
 NIOSH Homepage NIOSH A-Z
Workplace Safety & Health Topics
Publications and Products
Programs
Contact NIOSH


About CDC
					Contact Us
					800-232-4636
 Facebook Twitter Instagram LinkedIn Youtube Pinterest Snapchat
 CONTACT CDC
				Contact Us
							Call 800-232-4636
							Email Us
			ABOUT CDC
				About CDC
							Jobs
							Funding
			POLICIES
				Accessibility
							External Links
							Privacy
							Policies
							No Fear Act
							FOIA
							OIG
							Nondiscrimination
							Vulnerability Disclosure Policy
			CONNECT WITH US
				Facebook
								Twitter
								Instagram
								LinkedIn
							Youtube
								Pinterest
								Snapchat
								Email
			LANGUAGES
				Español
							繁體中文
							Tiếng Việt
							한국어
							Tagalog
							Русский
							العربية
							Kreyòl Ayisyen
							Français
							Polski
							Português
							Italiano
							Deutsch
							日本語
							فارسی
							English


U.S. Department of Health & Human Services
			Accessibility
			External Links
			Privacy
			Policies
			No Fear Act
			FOIA
			Nondiscrimination
			OIG
			Vulnerability Disclosure Policy
			USA.gov


Exit Notification/Disclaimer Policy Close
 Links with this icon  indicate that you are leaving the CDC website. The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website.
					Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website.
					You will be subject to the destination website's privacy policy when you follow the link.
					CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website. Website Disclaimers
 Cancel Continue