Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link


Centers for Disease Control and Prevention. CDC twenty four seven. Saving Lives, Protecting People
					Search
		×
			NIOSH
			NIOSH
				All CDC
				Submit
			For a full list of topics:A-Z Index
			Advanced Search
		Advanced Search


The National Institute for Occupational Safety and Health (NIOSH)


Facebook
        Twitter
        LinkedIn
        Syndicate





Methyl isobutyl carbinol																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 108–11–2
**NIOSH REL:** 25 ppm (100 mg/m3) TWA, 40 ppm (165 mg/m3) STEL [skin]
**Current OSHA PEL:** 25 ppm (100 mg/m3) TWA [skin]
**1989 OSHA PEL:** 25 ppm (100 mg/m3) TWA, 40 ppm (165 mg/m3) STEL [skin]
**1993-1994 ACGIH TLV:** 25 ppm (104 mg/m3) TWA, 40 ppm (167 mg/m3) STEL
**Description of substance:** Colorless liquid with a mild odor.
**LEL:** . . . 1.0% (10% LEL, 1,000 ppm)
**Original (SCP) IDLH:** 2,000 ppm
**Basis for original (SCP) IDLH:** The chosen IDLH is based on the statements by Browning [1965] and Patty [1963] that exposures for 8 hours to 2,000 ppm killed 5 of 6 rats, but no rats died from a 2-hour exposure to the saturated vapor [Smyth et al. 1951].
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA**:
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50 (ppm)**
    **LCLo (ppm)**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived value**Rat
    Browning 1965
    LC83: 2,000
    -----
    8 hr
    5,000 ppm (2.5)
    500 ppmRat
    Carpenter et al. 1949
    2,000
    -----
    4 hr
    4,000 ppm (2.0)
    400 ppmMouse
    McOmie & Anderson 1949
    LC60: 4,600
    -----
    10 hr
    12,420 ppm (2.7)
    1,242 ppm**Lethal dose data:**
 
 **Species**
    **Reference**
    **Route**
    **LD50 (mg/kg)**
    **LDLo (mg/kg)**
    **Adjusted LD**
    **Derived value**Mouse Rat
    McOmie &Anderson 1949 Smyth et al. 1951
    oral oral
    ----- 2,590
    1,000 -----
    1,647 ppm 4,266 ppm
    165 ppm 427 ppm**Other animal data:** It has been reported that rats survived a 2-hour exposure to the saturated vapor (about 4,000 ppm at 68°F) [Smyth et al. 1951].
 **Human data:** Eye irritation has occurred after exposures to 50 ppm for 15 minutes [Silverman et al. 1946].
 
 **Revised IDLH:** 400 ppm **Basis for revised IDLH:** The revised IDLH for methyl isobutyl carbinol is 400 ppm based on acute inhalation toxicity data in animals [Browning 1965; Carpenter et al. 1949]. This may be a conservative value due to the lack of relevant acute toxicity data for workers exposed to concentrations above 50 ppm.**REFERENCES:**
1. Browning E [1965]. Toxicity and Metabolism of Industrial Solvents. New York, NY: Elsevier Publishing Company, p. 369.
2. Carpenter CP, Smyth HF Jr, Pozzani UC [1949]. The assay of acute vapor toxicity, and the grading and interpretation of results on 96 chemical compounds. J Ind Hyg Toxicol *31*:343-346.
3. McOmie WA, Anderson HH [1949]. Comparative toxicologic effects of some isobutyl carbinols and ketones. University of California Publication, Pharmacology *2*:217-230.
4. Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 1460.
5. Silverman L, Schulte HF, First MW [1946]. Further studies on sensory response to certain industrial solvent vapors. J Ind Hyg Toxicol *28*:262-266.
6. Smyth HF Jr, Carpenter CP, Weil CS [1951]. Range-finding toxicity data: list IV. AMA Arch Ind Hyg Occup Med *4*:119-122.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
Pinterest
Twitter
YouTube
 NIOSH Homepage NIOSH A-Z
Workplace Safety & Health Topics
Publications and Products
Programs
Contact NIOSH


About CDC
					Contact Us
					800-232-4636
 Facebook Twitter Instagram LinkedIn Youtube Pinterest Snapchat
 CONTACT CDC
				Contact Us
							Call 800-232-4636
							Email Us
			ABOUT CDC
				About CDC
							Jobs
							Funding
			POLICIES
				Accessibility
							External Links
							Privacy
							Policies
							No Fear Act
							FOIA
							OIG
							Nondiscrimination
							Vulnerability Disclosure Policy
			CONNECT WITH US
				Facebook
								Twitter
								Instagram
								LinkedIn
							Youtube
								Pinterest
								Snapchat
								Email
			LANGUAGES
				Español
							繁體中文
							Tiếng Việt
							한국어
							Tagalog
							Русский
							العربية
							Kreyòl Ayisyen
							Français
							Polski
							Português
							Italiano
							Deutsch
							日本語
							فارسی
							English


U.S. Department of Health & Human Services
			Accessibility
			External Links
			Privacy
			Policies
			No Fear Act
			FOIA
			Nondiscrimination
			OIG
			Vulnerability Disclosure Policy
			USA.gov


Exit Notification/Disclaimer Policy Close
 Links with this icon  indicate that you are leaving the CDC website. The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website.
					Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website.
					You will be subject to the destination website's privacy policy when you follow the link.
					CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website. Website Disclaimers
 Cancel Continue