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alpha-Chloroacetophenone																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 532–27–4
**NIOSH REL:** 0.3 mg/m3 (0.05 ppm) TWA
**Current OSHA PEL:** 0.3 mg/m3 (0.05 ppm) TWA
**1989 OSHA PEL:** Same as current PEL
**1993-1994 ACGIH TLV:** 0.32 mg/m3 (0.05 ppm) TWA
**Description of Substance:** Colorless to gray crystalline solid with a sharp, irritating odor.
**LEL:** . . Unknown
**Original (SCP) IDLH:** 100 mg/m3
**Basis for original (SCP) IDLH:** ACGIH [1971] reported that the effective concentration to produce casualties as estimated from volunteer exposure is greater than 100 mg/m3. Deichmann and Gerarde [1969] reported that a fatality followed an exposure of less than 20 minutes to high concentrations of vapor (5.4 grams in a 34 m3 room, which is roughly equivalent to 160 mg/m3). Based on the data cited above, an IDLH of 100 mg/m3 is chosen.
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50**
    **LCLo**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived** **value**Rat MouseRabbitG. pigHumanHuman
    Ballantyne and Swanston 1978 Ballantyne and Swanston 1978Ballantyne and Swanston 1978Ballantyne and Swanston 1978Deichmann and Gerarde 1969Prentiss 1937
    ----- -------------------------
    417 mg/m3600 mg/m3465 mg/m3490 mg/m3159 mg/m3850 mg/m3
    15 min 15 min20 min30 min20 min10 min
    329 mg/m3 (0.79) 474 mg/m3 (0.79)405 mg/m3 (0.87490 mg/m3 (1.0)138 mg/m3 (0.87)587 mg/m3 (0.69)
    33 mg/m347 mg/m341 mg/m349 mg/m314 mg/m359 mg/m3
 **Other animal data:** RD50 (mouse), 6.2 mg/m3 [Alarie 1981].
 **Other human data:** It has been reported that 31 mg/m3 is intolerable after 3 minutes [Punte et al. 1962].
 
 **Revised IDLH:** 15 mg/m3**Basis for revised IDLH:** The revised IDLH for -chloroacetophenone is 15 mg/m3 based on acute inhalation toxicity data in humans [Deichmann and Gerarde 1969; Punte et al. 1962].
**REFERENCES:**
1. ACGIH [1971]. alpha-Chloroacetophenone. In: Documentation of threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 48-49.
2. Alarie Y [1981]. Dose-response analysis in animal studies: prediction of human responses. Environ Health Perspect *42*:9-13.
3. Ballantyne B, Swanston DW [1978]. The comparative acute mammalian toxicity of 1-chloroacetophenone (CN) and 2-chlorobenzylidene malononitrile (CS). Arch Toxicol *40*:75-95.
4. Deichmann WB, Gerarde HW [1969]. Chloroacetophenone. In: Toxicology of drugs and chemicals. New York, NY: Academic Press, Inc., p. 163.
5. Prentiss AM [1937]. Chemicals in war. A treatise on chemical warfare. New York, NY: McGraw-Hill Book Company, Inc., pp. 142-144.
6. Punte CL, Ballard TA, Weimer JT [1962]. Inhalation studies with chloroacetophenone, diphenylaminochloroarsine and pelargonic morpholide. I. Animal exposures. Am Ind Hyg Assoc J *23*:194-198.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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