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Hydrogen peroxide																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 7722–84–1
**NIOSH REL:** 1 ppm (1.4 mg/m3) TWA
**Current OSHA PEL:** 1 ppm (1.4 mg/m3) TWA
**1989 OSHA PEL:** Same as current PEL
**1993-1994 ACGIH TLV:** 1 ppm (1.4 mg/m3) TWA
**Description of Substance:** Colorless liquid with a slightly sharp odor.
**LEL:**. . Noncombustible Liquid
**Original (SCP) IDLH:** 75 ppm
**Basis for original (SCP) IDLH:** The chosen IDLH is based on the statement by AIHA [1957] that the short exposure tolerance is unknown for man, but is probably 75 ppm. AIHA [1957] also reported that a single 4­hour exposure to 75 ppm was tolerated by mice but higher concentrations produced delayed deaths [Svirbely]. According to AIHA [1957], concentrations in excess of 1,000 ppm would probably be lethal after a few minutes [Svirbely].
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA:**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50** **(ppm)**
    **LCLo** **(ppm)**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived value**Rat
    Gig Tr Prof Zabol 1977
    1,418
    -----
    4 hr
    2,836 ppm (2.0)
    284 ppmMouse
    Stokinger & Scheel 1962
    -----
    227
    ?
    ?
    ?**Lethal dose data:**
 
 **Species**
    **Reference**
    **Route**
    **LD50** **(mg/kg)**
    **LDLo** **(mg/kg)**
    **Adjusted LD**
    **Derived value**Mouse
    Lyazsky et al. 1983
    oral
    2,000
    -----
    9,929 ppm
    993 ppm**Other animal data:** It has been reported that mice tolerated a single 4­hour exposure to 75 ppm [Svirbely].
 **Human data:** It has been stated that although the short­term exposure tolerance is unknown, it is probably about 75 ppm [AIHA 1957]. Death has resulted in a man who drank 100 ml [Raukhverger and Solodko 1974].
 
 **Revised IDLH:** 75 ppm [Unchanged] **Basis for revised IDLH:** Based on acute inhalation data in humans [AIHA 1957] and animals [Svirbely], the original IDLH for hydrogen peroxide (75 ppm) is not being revised at this time.**REFERENCES:**
1. AIHA [1957]. Hydrogen peroxide (90%). In: Hygienic guide series. Am Ind Hyg Assoc Q *18*:275­276.
2. Gig Tr Prof Zabol [1977]; *21*(10):22­25 (in Russian).
3. Lyazsky PP, Gleiberman SE, et al. [1983]. Toxicological and hygienic characterization of decontaminating preparations based on hydrogen peroxide and its derivatives. Gig Sanit *48*(6):28­31 (in Russian).
4. Raukhverger AB, Solodko ON [1974]. Intoxication with concentrated hydrogen peroxide. Sudebno­Meditsinkaya Ekspertiza (Forensic Medical Examination) *17*(1):53­54 (in Russian).
5. Stokinger HE, Scheel LD [1962]. Ozone toxicity: immunochemical and tolerance­producing aspects. Arch Environ Health *4*:327­334.
6. Svirbely JL [?]. Unpublished results. Cincinnati, OH: U.S. Public Health Service. [From AIHA [1957]. Hydrogen peroxide (90%). In: Hygienic guide series. Am Ind Hyg Assoc Q *18*:275­276.]

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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