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Propylene imine																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 75–55–8
**NIOSH REL:** 2 ppm (5 mg/m3) TWA [skin]; NIOSH considers propylene imine to be a potential occupational carcinogen as defined by the OSHA carcinogen policy [29 CFR 1990].
**Current OSHA PEL:** 2 ppm (5 mg/m3) TWA [skin]
**1989 OSHA PEL:** Same as current PEL
**1993-1994 ACGIH TLV:** 2 ppm (4.7 mg/m3) TWA [skin], A2
**Description of substance:** Colorless, oily liquid with an ammonia-like odor.
**LEL:** . Unknown
**Original (SCP) IDLH:** 500 ppm
**Basis for original (SCP) IDLH:** The chosen IDLH is based on the statements by Patty [1963] that 5 of 6 rats died from a 4-hour exposure to 500 ppm and 3 of 5 guinea pigs died from a 2-hour exposure to 500 ppm; at 500 ppm, rats survived a 2-hour exposure, and guinea pigs survived a 30-minute exposure [Carpenter et al. 1948].
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA:**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50** **(ppm)**
    **LCLo** **(ppm)**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived value**Rat G. pigG. pigG. pigRat
    Carpenter et al. 1949 Carpenter et al. 1948Carpenter et al. 1948Carpenter et al. 1948Carpenter et al. 1948
    ----- LC17 : 500LC60 : 500LC100: 500LC83 : 500
    500 --------------------
    4 hr 1 hr2 hr4 hr4 hr
    1,000 ppm (2.0) 625 ppm (1.25)800 ppm (1.6)1,000 ppm (2.0)1,000 ppm (2.0)
    100 ppm 63 ppm80 ppm100 ppm100 ppm**Other animal data:** It has been reported that rats survived a 2-hour exposure to 500 ppm and guinea pigs survived a 30-minute exposure to 500 ppm [Carpenter et al. 1948].
 **Human data:** None relevant for use in determining the revised IDLH.
 
 **Revised IDLH:** 100 ppm **Basis for revised IDLH:** The revised IDLH for propylene imine is 100 ppm based on acute inhalation toxicity data in animals [Carpenter et al. 1948, 1949]. [Note: NIOSH recommends as part of its carcinogen policy that the "most protective" respirators be worn for propylene imine at concentrations above 2 ppm.]**REFERENCES:**
1. Carpenter CP, Smyth HF Jr, Pozzani UC [1949]. The assay of acute vapor toxicity, and the grading and interpretation of results on 96 chemical compounds. J Ind Hyg Toxicol *31*:343-346.
2. Carpenter CP, Smyth HF Jr, Shaffer CB [1948]. The acute toxicity of ethylene imine to small animals. J Ind Hyg Toxicol *30*:2-6.
3. Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 2175.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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