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Dichlorotetrafluoroethane																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 76–14–2
**NIOSH REL:** 1,000 ppm (7,000 mg/m3) TWA
**Current OSHA PEL:** 1,000 ppm (7,000 mg/m3) TWA
**1989 OSHA PEL:** Same as current PEL
**1993-1994 ACGIH TLV:** 1,000 ppm (6,990 mg/m3) TWA
**Description of Substance:** Colorless gas with a faint, ether-like odor at high concentrations.
**LEL:**. . Nonflammable Gas
**Original (SCP) IDLH:** 50,000 ppm
**Basis for original (SCP) IDLH:** Dichlorotetrafluoroethane is known to be a narcotic in high concentrations, but no human exposure data are available concerning its narcotic effects. Based on an analogy with dichlorodifluoromethane, a related compound that produces dizziness in humans at 50,000 ppm [ILO 1971], an IDLH of 50,000 ppm is assumed for this draft technical standard.
**Existing short-term exposure guidelines:** National Research Council [NRC 1984] Emergency Exposure Guidance Levels (EEGLs):
1-hr EEGL: 10,000 ppm
24-hr EEGL: 1,000 ppm
**ACUTE TOXICITY DATA**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50** **(ppm)**
    **LCLo** **(ppm)**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived** **value**Rat MouseRabbit
    Paulet 1976 Paulet 1976Paulet 1976
    720,000 700,000750,000
    ----- ----------
    30 min 30 min30 min
    720,000 ppm (1.0) 700,000 ppm (1.0)750,000 ppm (1.0)
    72,000 ppm 70,000 ppm75,000 ppm
 **Other animal data:** Evidence of serious arrhythmia was noted in 1 of 12 dogs exposed for 5 minutes to 25,000 ppm plus intravenous epinephrine [Reinhardt et al. 1971]. Cardiac sensitization has been induced with endogenous epinephrine at 50,000 to 800,000 ppm [Mullin et al. 1972; Reinhardt et al. 1971].
 **Human data:** Significant reduction in ventilatory lung capacity, bradycardia, and increased variability in heart rate have been reported following exposures to 2,300 to 21,400 ppm for 15, 45, or 60 seconds [IPCS 1990].
 
 **Revised IDLH:** 15,000 ppm **Basis for revised IDLH:** The revised IDLH for dichlorotetrafluoroethane is 15,000 ppm based on acute inhalation toxicity data in animals [Reinhardt et al. 1971] and an analogy to dichlorodifluoroethane, another closely related halogenated hydrocarbon, which has a revised IDLH of 15,000 ppm.
**REFERENCES:**
1. ILO [1971]. Fluorocarbons. In: Encyclopaedia of occupational health and safety. 2nd ed. Vol. I (A-K). Geneva, Switzerland: International Labour Office, pp. 560-562.
2. IPCS [1990]. Environmental criteria 13. Fully halogenated chlorofluorocarbons. Geneva, Switzerland: World Health Organization, International Programme on Chemical Safety.
3. Mullin LS, Azar A, Reinhardt CF, Smith PE Jr, Fabryka EF [1972]. Halogenated hydrocarbon-induced cardiac arrhythmias with release of endogenous epinephrine. Am Ind Hyg Assoc J *33*:389-396.
4. NRC [1984]. Emergency and continuous exposure limits for selected airborne contaminants. Vol. 1. Washington, DC: National Academy Press, Committee on Toxicology, Board on Toxicology and Environmental Health Hazards, Commission on Life Sciences, National Research Council, pp. 51-55.
5. Paulet G [1976]. Les fluorocarbones en question. J Eur Toxicol (Supplement) *9*(7):385-407 (in French).
6. Reinhardt CF, Azar A, Maxfield ME, et al. [1971]. Cardiac arrhythmias and aerosol sniffing. Arch Environ Health *22*:265-279.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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