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Aldrin																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 309-00-2
**NIOSH REL:** 0.25 mg/m3 TWA [skin]; NIOSH considers aldrin to be a potential occupational carcinogen as defined by the OSHA carcinogen policy [29 CFR 1990].
**Current OSHA PEL:** 0.25 mg/m3 TWA [skin]
**1989 OSHA PEL:** Same as current PEL
**1993-1994 ACGIH TLV:** 0.25 mg/m3 TWA [skin]
**Description of substance:** Colorless to dark-brown crystalline solid with a mild chemical odor.
**LEL:** Noncombustible Solid
**Original (SCP) IDLH:** 100 mg/m3
**Basis for original (SCP) IDLH:** No useful data on acute inhalation toxicity are available on which to base the IDLH for aldrin. The chosen IDLH, therefore, has been estimated from the statement by Baskin [1975] that severe symptoms follow swallowing or skin contamination with 15 to 50 mg/kg (average adult). According to Deichmann [1973], aldrin vapor gave no effect in man at 18 mg/m3 during exposure for 1 day.
**Short-term exposure guidelines:** None developed
ACUTE TOXICITY DATA
**Lethal concentration data:**
AdjustedLC50
    LCLo
    
    0.5-hr
    DerivedSpecies
    Reference
    (ppm)
    (ppm)
    Time
    LC (CF)
    ValueRat
    Izmerov et al. 1982
    -----
    5.8 mg/m3
    4 hr
    12 mg/m3 (2.0)
    1.2 mg/m3**Lethal dose data:** 
 LL50
    LCLo
    
    DerivedSpecies
    Reference
    Route
    (mg/kg)
    (mg/kg)
    Adjusted LD
    ValueRabbit
    AAPCO 1966
    oral
    50
    -----
    350 mg/m3
    35 mg/m3G. pig
    AAPCO 1966
    oral
    33
    -----
    231 mg/m3
    23 mg/m3Rat
    Kenaga and Morgan 1978
    oral
    39
    -----
    273 mg/m3
    27 mg/m3Mouse
    Kenaga and Morgan 1978
    oral
    44
    -----
    308 mg/m3
    31 mg/m3**Human data:** No effects were noted after exposure to 18 mg/m3 for 1 day [Deichmann 1973]. Ingestion of 25.6 mg/kg caused convulsions within 20 minutes [Ottolenghi et al. 1974]. [Note: An oral dose of 25.6 mg/kg is equivalent to a 70-kg worker being exposed to about 1,200 mg/m3 for 30 minutes, assuming a breathing rate of 50 liters per minute and 100% absorption.]
 **Revised IDLH:** 25 mg/m3**Basis for revised IDLH:** The revised IDLH for aldrin is 25 mg/m3 based on acute toxicity data in humans [Deichmann 1973; Ottolenghi et al. 1974]. [Note: NIOSH recommends as part of its carcinogen policy that the "most protective" respirators be worn for aldrin at concentrations above 0.25 mg/m3.]References:
AAPCO [1966]. Pesticide chemicals official compendium. Topeka, KS: Association of American Pesticide Control Officials, Inc., p. 7.
Baskin AD, ed. [1975]. Handling guide for potentially hazardous materials. Oxford, IN: The Richard B. Cross Company, PC 0180.
Deichmann WB [1973]. The chronic toxicity of organochlorine pesticides in man. In: Pesticides and the environment: a continuing controversy. Vol. II. New York, NY: Intercontinental Medical Book Corporation, pp. 347-420.
Izmerov NF, Sanotsky IV, Sidorov KK [1982]. Toxicometric parameters of industrial toxic chemicals under single exposure. Moscow, Russia: Centre of International Projects, GKNT, p. 73.
Kenaga EE, Morgan RW [1978]. Commercial and experimental organic insecticides (1978 revision). Entomological Society of America Special Publication 78-1:12.
Ottolenghi AD, Haseman JK, Suggs F [1974]. Teratogenic effects of aldrin, dieldrin, and endrin in hamsters and mice. Teratology 9:11.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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