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1,1,2,2-Tetrachloroethane																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 79-34-5
**NIOSH REL:** 1 ppm (7 mg/m3) TWA [skin]; NIOSH considers 1,1,2,2-tetrachloroethane to be a potential occupational carcinogen as defined by the OSHA carcinogen policy [29 CFR 1990].
**Current OSHA PEL:** 5 ppm (35 mg/m3) TWA [skin]
**1989 OSHA PEL:** 1 ppm (7 mg/m3) TWA [skin]
**1993-1994 ACGIH TLV:** 1 ppm (6.9 mg/m3) TWA [skin**]**
**Description of substance:** Colorless to pale-yellow liquid with a pungent, chloroform-like odor.
**LEL: . .** Noncombustible Liquid
**Original (SCP) IDLH:** 150 ppm
**Basis for original (SCP) IDLH:** The chosen IDLH is based on the statement by Negherbon [1959] that a 30-minute exposure to 146 ppm caused vertigo (along with irritation of the mucous membranes, sense of pressure in the head, and fatigue) in humans; the same effects were noted after a 10-minute exposure to 335 ppm [Lehmann et al. 1936].
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA:**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50** **(ppm)**
    **LCLo** **(ppm)**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived value**Rat MouseCatRat
    Carpenter et al. 1949 Izmerov et al. 1982Lehmann et al. 1936Smyth 1956
    ----- ----------1,000
    1,000 6432,714-----
    4 hr 2 hr45 min4 hr
    2,000 ppm (2.0) 1,029 ppm (1.6)3,094 ppm (1.14)2,000 ppm (2.0)
    200 ppm 103 ppm309 ppm200 ppm**Human data:** A 30-minute exposure to 146 ppm has caused vertigo, irritation of the mucous membranes, sense of pressure in the head, and fatigue; the same effects were noted after a 10-minute exposure to 335 ppm [Lehmann et al. 1936; Negherbon 1959].
 
 **Revised IDLH:** 100 ppm **Basis for revised IDLH:** The revised IDLH for 1,1,2,2-tetrachloroethane is 100 ppm based on acute inhalation toxicity data in humans [Lehmann et al. 1936; Negherbon 1959] and animals [Izmerov et al. 1982]. [Note: NIOSH recommends as part of its carcinogen policy that the "most protective" respirators be worn for 1,1,2,2-tetrachloroethane at concentrations above 1 ppm.]**REFERENCES:**
1. Carpenter CP, Smyth HF Jr, Pozzani UC [1949]. The assay of acute vapor toxicity and the grading and interpretation of results on 96 chemical compounds. J Ind Hyg Toxicol 31(6):343-346.
2. Izmerov NF, Sanotsky IV, Sidorov KK [1982]. Toxicometric parameters of industrial toxic chemicals under single exposure. Moscow, Russia: Centre of International Projects, GKNT, p. 75.
3. Lehmann KB, Schmidt-Kehl L, Ruf H, Crescitelli, Dahl, Eppinghausen, Eshe, Falker, Grotefendt, Junkenita, Maier, Mergner, Pantehtsch, Schlitzer, Shoenes, Spettmann, Wirges, Bamsreiter, Benninger, Lazarus, Manasse, Kummeth, Reuss, Schwarzweller [1936]. The 13 most important chlorinated hydrocarbons of the aliphatic series from the standpoint of occupational hygiene. Arch Hyg Bakteriol 116:132-200 (translated).
4. Negherbon WO [1959]. Handbook of toxicology. Vol. III. Insecticides, a compendium. Wright-Patterson Air Force Base, OH: U.S. Air Force, Air Research and Development Command, Wright Air Development Center, Aero Medical Laboratory, WADC Technical Report 55-16, p. 735.
5. Smyth HF Jr [1956]. Improved communication: hygienic standards for daily inhalation. Am Ind Hyg Assoc Q 17(2):129-185.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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