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n-Butylamine																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 109–73–9
**NIOSH REL:** 5 ppm (15 mg/m3) CEILING [skin]
**Current OSHA PEL:** 5 ppm (15 mg/m3) CEILING [skin]
**1989 OSHA PEL:** Same as current PEL
**1993-1994 ACGIH TLV:** 5 ppm (15 mg/m3) CEILING [skin]
**Description of Substance:** Colorless liquid with a fishy, ammonia-like odor.
**LEL:** . . 1.7% (10% LEL, 1,700 ppm)
**Original (SCP) IDLH:** 2,000 ppm
**Basis for original (SCP) IDLH:** The chosen IDLH is based on the statement by AIHA [1960] that no rats died after a 4-hour exposure to 2,000 ppm [Smyth 1956], but 3 of 3 rats died after a 50-minute exposure to 3,100 ppm [Terhaar]. No other data on acute inhalation toxicity are available on which to base the IDLH.
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50** **(ppm)**
    **LCLo** **(ppm)**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived** **value**RatRatMouseRat
    AIHA 1960Carpenter et al.1949Izmerov et al. 1982Smyth 1956
    LC100: 3,100 ----------LC100: 4,000
    -----4,000263-----
    50 min4 hr2 hr2-5 min
    3,658 ppm (1.18)8,000 ppm (2.0)410 ppm (1.6)1,600-2,200 ppm (0.4/055)
    366 ppm800 ppm41 ppm160-220 ppm
 **Lethal dose data:**
 
 **Species**
    **Reference**
    **Route**
    **LD50** **(mg/kg)**
    **LDLo** **(mg/kg)**
    **Adjusted LD**
    **Derived value**Rat MouseG. pig
    Cheever et al. 1982 Trubko 1975Trubko 1975
    oral oraloral
    366 430430
    ----- ----------
    843 ppm 990 ppm990 ppm
    84 ppm 99 ppm99 ppm
 **Other animal data:** Rats have survived a 4-hour exposure to 2,000 ppm [Cheever et al. 1982]. It has been stated that butylamine is more than twice as toxic as ethylamine by the respiratory route [ACGIH 1991].
 **Human data:** None relevant for use in determining the revised IDLH.
 
 **Revised IDLH:** 300 ppm **Basis for revised IDLH:** The revised IDLH for n-butylamine is 300 ppm based on acute inhalation toxicity data in animals [AIHA 1960; Smyth 1956] and an analogy [ACGIH 1991] to ethylamine which has a revised IDLH of 600 ppm.
**REFERENCES:**
1. ACGIH [1991]. n-Butylamine. In: Documentation of the threshold limit values and biological exposure indices. 6th ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 176-177.
2. AIHA [1960]. n-Butylamine. In: Hygienic guide series. Am Ind Hyg Assoc J *21*:532-533.
3. Carpenter CP, Smyth HF Jr, Pozzani UC [1949]. The assay of acute vapor toxicity and the grading and interpretation of results on 96 chemical compounds. J Ind Hyg Toxicol *31*(6):343-346.
4. Cheever KL, Richards DE, Plotnick HB [1982]. The acute oral toxicity of isomeric monobutylamines in the adult male and female rat. Toxicol Appl Pharmacol *63*:150-152.
5. Izmerov NF, Sanotsky IV, Sidorov KK [1982]. Toxicometric parameters of industrial toxic chemicals under single exposure. Moscow, Russia: Centre of International Projects, GKNT, p. 28.
6. Smyth HF Jr [1956]. Improved communication: hygienic standards for daily inhalation. Am Ind Hyg Assoc Q *17*:129-185.
7. Terhaar CJ [?]. Personal communication to AIHA from the Laboratory of Industrial Medicine, Eastman Kodak Company, Rochester, NY. [From AIHA [1960]. n-Butylamine. In: Hygienic guide series. Am Ind Hyg Assoc J *21*:532-533.]
8. Trubko EI [1975]. Investigations on hygienic standardization of n-butylamines in water bodies. Gig Sanit *40*(11):21-23 (in Russian).

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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