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|  (Mark      One)                                                                                                                                                                                                                                                                                                                      |
|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| ý                                                                                                                                                                                                                                                                                                                                     |   | ANNUAL      REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF      1934 |
|                                                                                                                                                                                                                                                                                                                                       |   |   |
| For      the fiscal year ended December 31, 2007                                                                                                                                                                                                                                                                                      |
|                                                                                                                                                                                                                                                                                                                                       |   |   |
| OR                                                                                                                                                                                                                                                                                                                                         |
|                                                                                                                                                                                                                                                                                                                                       |   |   |
| o                                                                                                                                                                                                                                                                                                                                          |   | TRANSITION      REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF      1934 |
|                                                                                                                                                                                                                                                                                                                                       |   |   |
| For      the transition period      from                        to                         |
|                                                                                                                                                                                                                                                                                                                                       |   |   |
| Commission      file number 0-32501                                                                                                                                                                                                                                                                                                        |

| DELAWARE                                                                |   | 33-0827593                                    |
|-------------------------------------------------------------------------|--------|-----------------------------------------------|
| (State      or Other Jurisdictionof      Incorporation or Organization) |   | (I.R.S.      EmployerIdentification      No.) |
|                                                                    |   |                                          |
| 3020      CALLAN ROAD, SAN DIEGO, CALIFORNIA                            |   | 92121                                         |
| (Address      of principal executive offices)                           |   | (Zip      Code)                               |

| Title of Each Class                 |   | Name of Each Exchange on Which      Registered |
|-------------------------------------|--------|------------------------------------------------|
| Common      stock, par value $0.001 |   | The      NASDAQ Stock Market LLC               |

| Large      Accelerated Filer   o   | Accelerated      Filer ý | Non-Accelerated      Filer o                  | Smaller      reporting company o |
|-------------------------------------------------------------|-------------------------------|----------------------------------------------------|---------------------------------------|
|                                                        |                          | (Do      not check if a smaller reporting company) |                                  |

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|                          | CYTORI      THERAPEUTICS, INC. |
|-------------------------------|--------------------------------|
|                          |                           |   |
|                          | By:                            | /s/      Christopher J. Calhoun |
| Dated:      December 17, 2008 |                           | Christopher      J. Calhoun |
|                          |                           | Chief      Executive Officer |
|                          |                           |   |
|                          | By:                            | /s/      Mark E. Saad |
| Dated:      December 17, 2008 |                           | Mark      E. Saad |
|                          |                           | Chief      Financial Officer |

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| Exhibit      Number |   | Description                                                                                                                                                                                |
|---------------------|--------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| 31.1                |   | Certification      of Principal Executive Officer Pursuant to Securities Exchange Act Rule      13a-14(a), as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of      2002  |
| 31.2                |   | Certification      of Principal Financial Officer Pursuant to Securities Exchange Act Rule      13a-14(a), as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of      2002       |

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