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1-Chloro-1-nitropropane																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 600–25–9
**NIOSH REL:** 2 ppm (10 mg/m3) TWA
**Current OSHA PEL:** 20 ppm (100 mg/m3) TWA
**1989 OSHA PEL:** 2 ppm (10 mg/m3) TWA
**1993-1994 ACGIH TLV:** 2 ppm (10 mg/m3) TWA
**Description of Substance:** Colorless liquid with an unpleasant odor.
**LEL:** . . Unknown
**Original (SCP) IDLH:** 2,000 ppm
**Basis for original (SCP) IDLH:** The chosen IDLH is based on the statement in Patty [1963] that 1 of 2 guinea pigs died following a 1-hour exposure to 2,178 ppm; no rabbits died from this exposure, and no rabbits or guinea pigs died from a 1-hour exposure to 1,069 ppm [Machle et al. 1945].
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50** **(ppm)**
    **LCLo** **(ppm)**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived** **value**G. pig RabbitRabbitG. pigMouse
    Machle et al. 1945 Machle et al. 1945Machle et al. 1945Machle et al. 1945Neklesova and Kudrina 1969
    2,178 -----LC100: 2,574-----12,840
    ----- 389-----3,502-----
    1 hr 6 hr6 hr2 hr3 hr
    2,723 ppm (1.25) 895 ppm (2.3)5,920 ppm (2.3)5,603 ppm (1.6)23,112 ppm (1.8)
    272 ppm 90 ppm592 ppm560 ppm2,311 ppm
 **Lethal dose data:**
 
 **Species**
    **Reference**
    **Route**
    **LD50** **(mg/kg)**
    **LDLo** **(mg/kg)**
    **Adjusted LD**
    **Derived value**Rabbit RatMouse
    Machle et al. 1945 Marhold 1986Neklesova and Kudrina 1969
    oral oraloral
    ----- -----510
    50 50-----
    68 ppm 68 ppm695 ppm
    6.8 ppm 6.8 ppm70 ppm
 **Human data** None relevant for use in determining the revised IDLH.
 
 **Revised IDLH:** 100 ppm **Basis for revised IDLH:** The revised IDLH for 1-chloro-1-nitropropane is 100 ppm based on acute inhalation toxicity data in animals [Machle et al. 1945].
**REFERENCES:**
1. Machle W, Scott EW, Treon JF, Heyroth FF, Kitzmiller KV [1945]. The physiological response of animals to certain chlorinated mononitroparaffins. J Ind Hyg Toxicol *27*(4):95-102.
2. Marhold J [1986]. Prehled Prumyslove Toxikologie, Organicke Latky. Prague, Czechoslovakia: Avicenum, p. 596 (in Czechoslovakian).
3. Neklesova ID, Kudrina MA [1969]. Comparative toxicological characteristics of certain chloronitroparaffins. Gig Sanit *34*(10-12):429-432 (translated).
4. Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 2082.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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