Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link


Centers for Disease Control and Prevention. CDC twenty four seven. Saving Lives, Protecting People
					Search
		×
			NIOSH
			NIOSH
				All CDC
				Submit
			For a full list of topics:A-Z Index
			Advanced Search
		Advanced Search


The National Institute for Occupational Safety and Health (NIOSH)


Facebook
        Twitter
        LinkedIn
        Syndicate





Dichloroethyl ether																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 111–44–4
**NIOSH REL:** 5 ppm (30 mg/m3) TWA, 10 ppm (60 mg/m3) STEL [skin]; NIOSH considers dichloroethyl ether to be a potential occupational carcinogen as defined by the OSHA carcinogen policy [29 CFR 1990].
**Current OSHA PEL:** 15 ppm (90 mg/m3) CEILING [skin]
**1989 OSHA PEL:** 5 ppm (30 mg/m3) TWA, 10 ppm (60 mg/m3) STEL [skin]
**1993-1994 ACGIH TLV:** 5 ppm (29 mg/m3) TWA, 10 ppm (58 mg/m3) STEL [skin]
**Description of Substance:** Colorless liquid with a chlorinated solvent-like odor.
**LEL:**. . 2.7% (10% LEL, 2,700 ppm)
**Original (SCP) IDLH:** 250 ppm
**Basis for original (SCP) IDLH:** The chosen IDLH is based on the statements by Patty [1963] that 250 ppm caused death in rats from a 4-hour exposure [Carpenter et al. 1949] and that 500 to 1000 ppm might cause death in guinea pigs from an exposure of only 30 to 60 minutes duration [Schrenk et al. 1933].
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50** **(ppm)**
    **LCLo** **(ppm)**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived** **value**Rat RatMouseG. pigG. pig
    Carpenter et al. 1949 Izmerov et al. 1982Izmerov et al. 1982Marhold 1986Schrenk et al. 1933
    ----- 77152500-----
    250 ---------------500
    4 hr 4 hr2 hr1 hr5 hr
    500 ppm (2.0) 154 ppm (2.0)243 ppm (1.6)625 ppm (1.25)1,075 ppm (2.15)
    50 ppm 15 ppm24 ppm63 ppm108 ppm
 **Human data:** Volunteers found brief (undefined) exposures to 100 to 260 ppm to be tolerable, although irritating [Schrenk et al. 1933].
 
 **Revised IDLH:** 100 ppm **Basis for revised IDLH:** The revised IDLH for dichloroethyl ether is 100 ppm based on acute inhalation toxicity data in humans [Schrenk et al. 1933]. This may be a conservative value due to the lack of relevant acute toxicity data for workers exposed to concentrations above 100 ppm. [Note: NIOSH recommends as part of its carcinogen policy that the "most protective" respirators be worn for dichloroethyl ether at concentrations above 5 ppm.]
**REFERENCES:**
1. Carpenter CP, Smyth HF Jr, Pozzani C [1949]. The assay of acute vapor toxicity, and the grading and interpretation of results on 96 chemical compounds. J Ind Hyg Toxicol *31*:343-346.
2. Izmerov NF, Sanotsky IV, Sidorov KK [1982]. Toxicometric parameters of industrial toxic chemicals under single exposure. Moscow, Russia: Centre of International Projects, GKNT, p. 45.
3. Marhold J [1986]. Prehled Prumyslove Toxikologie, Organicke Latky. Prague, Czechoslovakia: Avicenum, p. 541 (in Czechoslovakian).
4. Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 1675.
5. Schrenk HH, Patty FA, Yant WP [1933]. Acute response of guinea pigs to vapors of some new commercial organic compounds. VII. Dichloroethyl ether. Public Health Rep *48*(46):1389-1398.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
Pinterest
Twitter
YouTube
 NIOSH Homepage NIOSH A-Z
Workplace Safety & Health Topics
Publications and Products
Programs
Contact NIOSH


About CDC
					Contact Us
					800-232-4636
 Facebook Twitter Instagram LinkedIn Youtube Pinterest Snapchat
 CONTACT CDC
				Contact Us
							Call 800-232-4636
							Email Us
			ABOUT CDC
				About CDC
							Jobs
							Funding
			POLICIES
				Accessibility
							External Links
							Privacy
							Policies
							No Fear Act
							FOIA
							OIG
							Nondiscrimination
							Vulnerability Disclosure Policy
			CONNECT WITH US
				Facebook
								Twitter
								Instagram
								LinkedIn
							Youtube
								Pinterest
								Snapchat
								Email
			LANGUAGES
				Español
							繁體中文
							Tiếng Việt
							한국어
							Tagalog
							Русский
							العربية
							Kreyòl Ayisyen
							Français
							Polski
							Português
							Italiano
							Deutsch
							日本語
							فارسی
							English


U.S. Department of Health & Human Services
			Accessibility
			External Links
			Privacy
			Policies
			No Fear Act
			FOIA
			Nondiscrimination
			OIG
			Vulnerability Disclosure Policy
			USA.gov


Exit Notification/Disclaimer Policy Close
 Links with this icon  indicate that you are leaving the CDC website. The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website.
					Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website.
					You will be subject to the destination website's privacy policy when you follow the link.
					CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website. Website Disclaimers
 Cancel Continue