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Hydrazine																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 302–01–2
**NIOSH REL:** 0.03 ppm (0.04 mg/m3) 2-hour CEILING; NIOSH considers hydrazine to be a potential occupational carcinogen as defined by the OSHA carcinogen policy [29 CFR 1990].
**Current OSHA PEL:** 1 ppm (1.3 mg/m3) TWA [skin]
**1989 OSHA PEL:** 0.1 ppm (0.1 mg/m3) TWA [skin]
**1993-1994 ACGIH TLV:** 0.1 ppm (0.13 mg/m3) TWA [skin], A2
**Description of Substance:** Colorless, fuming, oily liquid with an ammonia-like odor.
**LEL:**. . 2.9% (10% LEL, 2,900 ppm)
**Original (SCP) IDLH:** 80 ppm
**Basis for original (SCP) IDLH:** The chosen IDLH is based on the statement by Patty [1963] that a 4-hour exposure to 80 to 300 ppm killed 14 of 30 rats [Comstock et al. 1954].
**Existing short-term exposure guidelines:** National Research Council [NRC 1985] Short-term Public Emergency Exposure Guidance Levels (SPEGLs):
1-hour SPEGL: 0.12 ppm
2-hour SPEGL: 0.16 ppm
4-hour SPEGL: 0.03 ppm
8-hour SPEGL: 0.015 ppm
16-hour SPEGL: 0.008 ppm
24-hour SPEGL: 0.005 ppm
**ACUTE TOXICITY DATA**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50** **(ppm)**
    **LCLo** **(ppm)**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived** **value**Rat RatRatRatRatRatMouse
    Comstock et al. 1954 Comstock et al. 1954Comstock et al. 1954Comstock et al. 1954Comstock et al. 1954Jacobson et al. 1955Jacobson et al. 1955
    LC17: 190 260LC33: 270LC83: 300630570252
    ----- ------------------------------
    4 hr 4 hr4 hr4 hr1 hr4 hr4 hr
    380 ppm (2.0) 520 ppm (2.0)540 ppm (2.0)600 ppm (2.0)788 ppm (1.25)1,140 ppm (2.0)504 ppm (2.0)
    38 ppm 52 ppm54 ppm60 ppm79 ppm114 ppm50 ppm
 **Lethal dose data:**
 
 **Species**
    **Reference**
    **Route**
    **LD50** **(mg/kg)**
    **LDLo** **(mg/kg)**
    **Adjusted LD**
    **Derived value**Rat Mouse
    Swiecicki 1973 Swiecicki 1973
    oral oral
    60 59
    ----- -----
    316 ppm 311 ppm
    32 ppm 31 ppm
 **Human data:** None relevant for use in determining the revised IDLH.
 
 **Revised IDLH:** 50 ppm **Basis for revised IDLH:** The revised IDLH for hydrazine is 50 ppm based on acute inhalation toxicity data in animals [Comstock et al. 1954; Jacobson et al. 1955]. [Note: NIOSH recommends as part of its carcinogen policy that the "most protective" respirators be worn for hydrazine at concentrations above 0.03 ppm.]
**REFERENCES:**
1. Comstock CC, Lawson LH, Greene EA, Oberst FW [1954]. Inhalation toxicity of hydrazine vapor. Arch Ind Hyg Occup Med *10*:476-490.
2. Jacobson KH, Clem JH, Wheelwright HJ Jr, Rinehart WE, Mayes N [1955]. The acute toxicity of the vapors of some methylated hydrazine derivatives. AMA Arch Ind Health *12*:609-616.
3. NRC [1985]. Emergency and continuous exposure guidance levels for selected airborne contaminants. Vol. 5. Washington, DC: National Academy Press, Committee on Toxicology, Board on Toxicology and Environmental Health Hazards, Commission on Life Sciences, National Research Council, pp. 5-21.
4. Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 2224.
5. Swiecicki W [1973]. Toksykologia zwiazkow hydrazyny. Med Pr *24*:71-79 (in Polish).

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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