Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link


Centers for Disease Control and Prevention. CDC twenty four seven. Saving Lives, Protecting People
					Search
		×
			NIOSH
			NIOSH
				All CDC
				Submit
			For a full list of topics:A-Z Index
			Advanced Search
		Advanced Search


The National Institute for Occupational Safety and Health (NIOSH)


Facebook
        Twitter
        LinkedIn
        Syndicate





Endrin																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 72–20–8
**NIOSH REL:** 0.1 mg/m3 [skin] TWA
**Current OSHA PEL:** 0.1 mg/m3 TWA [skin]
**1989 OSHA PEL:** Same as current PEL
**1993-1994 ACGIH TLV:** 0.1 mg/m3 TWA [skin]
**Description of Substance:** Colorless to tan, crystalline solid with a mild, chemical odor.
**LEL:**. . Noncombustible Solid
**Original (SCP) IDLH*:** 2,000 mg/m3 [*Note: “Effective” IDLH = 200 mg/m3 — see discussion below.]
**Basis for original (SCP) IDLH:** Based on the statement by ACGIH [1971] that 3 of 10 rats were reported to have died following a 1-hour exposure at about 2,000 mg/m3 [Anderson et al. 1953; Hine et al. 1954], an IDLH of 2,000 mg/m3 was chosen. Because of the assigned protection factor afforded by each device, however, 2,000 × the OSHA PEL of 0.1 mg/m3 (i.e., 200 mg/m3) is the concentration above which only the “most protective” respirators are permitted.
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50**
    **LCLo**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived** **value**Rat
    ACGIH 1971
    LC30: 2,000 mg/m3
    -----
    1 hr
    2,500 mg/m3 (1.25)
    250 mg/m3
 **Lethal dose data:**
 
 **Species**
    **Reference**
    **Route**
    **LD50** **(mg/kg)**
    **LDLo** **(mg/kg)**
    **Adjusted LD**
    **Derived value**Monkey G. pigHamsterRatCatRabbitMouse
    AAPCO 1966 AAPCO 1966Ottolenghi et al. 1974Sanderson and Noakes 1970Treon et al. 1955Treon et al. 1955Webb et al. 1973
    oral oraloraloraloraloraloral
    3 16103-----71.4
    ----- ---------------5----------
    21 mg/m3112 mg/m370 mg/m321 mg/m335 mg/m349 mg/m310 mg/m3
    2.1 mg/m311 mg/m37.0 mg/m32.1 mg/m33.5 mg/m34.9 mg/m31.0 mg/m3
 **Human data:** An oral dose of 171 mg/kg has been reported to be lethal [Runhaar et al. 1985]. It has also been reported that the approximate oral dose producing convulsions is about 0.2 mg/kg [Hayes 1982]. [Note: Oral doses of 171 mg/kg or 0.2 mg/kg are equivalent to a 70-kg worker being exposed to about 8,000 mg/m3 or 9 mg/m3, respectively, for 30 minutes, assuming a breathing rate of 50 liters per minute and 100% absorption.]
 
 **Revised IDLH:** 2 mg/m3**Basis for revised IDLH:** The revised IDLH for endrin is 2 mg/m3 based on acute oral toxicity data in humans [Hayes 1982] and animals [AAPCO 1966; Sanderson and Noakes 1970; Treon et al. 1955; Webb et al. 1973]. This may be a conservative value due to the lack of relevant acute inhalation toxicity data for workers.
**REFERENCES:**
1. AAPCO [1966]. Pesticide chemicals official compendium. Association of the American Pesticide Control Officials, Inc., p. 475.
2. ACGIH [1971]. Endrin. In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 98.
3. Anderson HH, et al. [1953]. Berkeley, CA: University of California, Report No. 213. [From ACGIH [1971]. Endrin. In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 98.]
4. Hayes WH Jr [1982]. Pesticides studied in man. Baltimore, MD: Williams & Wilkins Company, pp. 247-251.
5. Hine CH, et al. [1954]. Berkeley, CA: University of California, Report No. 233. [From ACGIH [1971]. Endrin. In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 98.]
6. Ottolenghi AD, Haseman JK, Suggs F [1974]. Teratogenic effects of aldrin, dieldrin, and endrin in hamsters and mice. Teratology *9*:11-16.
7. Runhaar EA, Sangster B, Greve PA, Voortman M [1985]. A case of fatal endrin poisoning. Hum Toxicol *4*:241-247.
8. Sanderson DM, Noakes DN [1970]. Acute toxicity data for pesticides (1970). World Review of Pesticide Control *9*:119-127.
9. Treon JF, Cleveland FP, Cappel J [1955]. Toxicity of endrin for laboratory animals. J Agri Food Chem *3*:842-848.
10. Webb RE, Hartgrove RW, Randolph WC, Petrella VJ, Horsfall F Jr [1973]. Toxicity studies in endrin-susceptible and resistant strains of pine mice. Toxicol Appl Pharmacol *25*:42-47.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
Pinterest
Twitter
YouTube
 NIOSH Homepage NIOSH A-Z
Workplace Safety & Health Topics
Publications and Products
Programs
Contact NIOSH


About CDC
					Contact Us
					800-232-4636
 Facebook Twitter Instagram LinkedIn Youtube Pinterest Snapchat
 CONTACT CDC
				Contact Us
							Call 800-232-4636
							Email Us
			ABOUT CDC
				About CDC
							Jobs
							Funding
			POLICIES
				Accessibility
							External Links
							Privacy
							Policies
							No Fear Act
							FOIA
							OIG
							Nondiscrimination
							Vulnerability Disclosure Policy
			CONNECT WITH US
				Facebook
								Twitter
								Instagram
								LinkedIn
							Youtube
								Pinterest
								Snapchat
								Email
			LANGUAGES
				Español
							繁體中文
							Tiếng Việt
							한국어
							Tagalog
							Русский
							العربية
							Kreyòl Ayisyen
							Français
							Polski
							Português
							Italiano
							Deutsch
							日本語
							فارسی
							English


U.S. Department of Health & Human Services
			Accessibility
			External Links
			Privacy
			Policies
			No Fear Act
			FOIA
			Nondiscrimination
			OIG
			Vulnerability Disclosure Policy
			USA.gov


Exit Notification/Disclaimer Policy Close
 Links with this icon  indicate that you are leaving the CDC website. The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website.
					Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website.
					You will be subject to the destination website's privacy policy when you follow the link.
					CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website. Website Disclaimers
 Cancel Continue