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Vanadium dust																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 1314–62–1
**NIOSH REL:** 0.05 mg V/m3 15-minute CEILING
**Current OSHA PEL:** 0.5 mg V2O5/m3 (respirable dust) CEILING
**1989 OSHA PEL:** 0.05 mg V2O5/m3 (respirable dust) TWA
**1993-1994 ACGIH TLV:** 0.05 mg V2O5/m3 (respirable dust) TWA
**Description of substance:** Yellow-orange powder or dark-gray, odorless flakes dispersed in air.
**LEL:** . . Noncombustible Solid
**Original (SCP) IDLH:** 70 mg/m3 (as V2O5)
**Basis for original (SCP) IDLH:** The chosen IDLH is based on the statement by ACGIH [1971] that vanadium pentoxide dust at 70 mg/m3 is fatal to animals within a few hours [Hudson 1964]. AIHA [1957] reported that rabbits succumb from edema of the lungs at 200 mg/m3 after one 7-hour exposure [Sjoberg 1950].
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA:**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50**
    **LCLo**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived value**Cat
    Faulkner 1964
    -----
    500 mg/m3
    23 min
    256 mg V/m3 (0.915)
    26 mg V/m3Rat
    Izrael'son 1963
    -----
    70 mg/m3
    2 hr
    63 mg V/m3 (1.6)
    6.3 mg V/m3**Lethal dose data:**
 
 **Species**
    **Reference**
    **Route**
    **LD50** **(mg/kg)**
    **LDLo** **(mg/kg)**
    **Adjusted LD**
    **Derived value**Rat
    Arch Toxikol 1956
    oral
    10
    -----
    39 mg V/m3
    3.9 mg V/m3Mouse
    Izmerov et al. 1982
    oral
    23
    -----
    90 mg V/m3
    9.0 mg V/m3**Human data:** Respiratory irritation following exposures to V2O5 ranging from 1 to 48 mg V/m3 has been described in workers [Sjoberg 1955]. Vanadium intoxication (i.e., rhinorrhea, sneezing, lacrimation, and sore throat) has been reported in workers exposed to concentrations of V2O5 during the workshift ranging from 10 to 33 mg/m3 [Williams 1952]. Concentrations of V2O5 exceeding 56 mg V/m3 have resulted in local respiratory effects [Vintinner et al. 1955]. Other workers exposed intermittently to 56 mg V/m3 showed no evidence of intoxication [McTurk et al. 1956].
 
 **Revised IDLH:** 35 mg V/m3**Basis for revised IDLH:** Based on acute inhalation toxicity data in workers [McTurk et al. 1956; Sjoberg 1955; Vintinner et al. 1955; Williams 1952], the revised IDLH for vanadium dust is 35 mg V/m3.**REFERENCES:**
1. ACGIH [1971]. Vanadium (as V). In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 275-276.
2. AIHA [1957]. Vanadium pentoxide. In: Hygienic guide series. Am Ind Hyg Assoc Q *18*:172-173.
3. Arch Toxikol [1956]; *16*:182-189 (in German).
4. Faulkner TG [1964]. Vanadium toxicology and biological significance. New York, NY: Elsevier Science Publishing Co., p. 72.
5. Hudson TGF [1964]. Vanadium: toxicology and biological significance. New York, NY: Elsevier Publishing Company, p. 75.
6. Izmerov NF, Sanotsky IV, Sidorov KK [1982]. Toxicometric parameters of industrial toxic chemicals under single exposure. Moscow, Russia: Centre of International Projects, GKNT, p. 119.
7. Izrael’son ZI, ed. [1963]. Toxicology of the rare metals. Jerusalem, Israel: Israel Program for Scientific Translations.
8. McTurk LC, Hirs CHW, Eckard RE [1956]. Health hazards of vanadium-containing residual oil ash. Ind Med Surg *25*:29-36.
9. Sjoberg S-G [1950]. Vanadium pentoxide dust: a clinical and experimental investigation on its effect after inhalation. Acta Med Scand Suppl *238*:81-99.
10. Sjoberg SG [1955]. Vanadium bronchitis from cleaning oil-fired boilers. AMA Arch Ind Health *11*:505-512.
11. Vintinner FJ, Vallenas R, Carlin CE, Weiss R, Macher C, Ochoa R [1955]. Study of the health of workers employed in mining and processing of vanadium ore. AMA Arch Ind Health *12*:635-642.
12. Williams N [1952]. Vanadium poisoning from cleaning oil-fired boilers. Brit J Ind Med *9*:50-55.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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