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Diacetone alcohol																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 123–42–2
**NIOSH REL:** 50 ppm (240 mg/m3) TWA
**Current OSHA PEL:** 50 ppm (240 mg/m3) TWA
**1989 OSHA PEL:** Same as current PEL
**1993-1994 ACGIH TLV:** 50 ppm (238 mg/m3) TWA
**Description of Substance:** Colorless liquid with a faint, minty odor.
**LEL:**. . 1.8% (10% LEL, 1,800 ppm)
**Original (SCP) IDLH:** 2,100 ppm
**Basis for original (SCP) IDLH:** The only acute inhalation toxicity data available on which to base an IDLH for diacetone alcohol is the statement by Patty [1963] that animals exposed for 1 to 3 hours to 2,100 ppm exhibited restlessness, irritation of the membranes, excitement, and later somnolence [Gross as cited by Lehmann and Flury 1943]. The chosen IDLH is obviously conservative.
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA**
**Lethal dose data:**

**Species**
    **Reference**
    **Route**
    **LD50** **(mg/kg)**
    **LDLo** **(mg/kg)**
    **Adjusted LD**
    **Derived value**Rat RabbitMouse
    Smyth and Carpenter 1948 Walton et al. 1928Wenzel and Koff 1956
    oral oraloral
    4,000 4,6533,950
    ----- ----------
    5,797 ppm 6,743 ppm5,725 ppm
    580 ppm 674 ppm573 ppm
 **Other animal data:** Animals exposed for 1 to 3 hours to 2,100 ppm exhibited restlessness, irritation of the membranes, excitement, and later, somnolence [Lehmann and Flury 1943].
 **Human data:** It has been reported that eye irritation appeared in volunteers exposed for 15 minutes at 100 ppm [Silverman et al. 1946].
 
 **Revised IDLH:** 1,800 ppm (LEL) **Basis for revised IDLH:** Based on health considerations and acute inhalation toxicity data in animals [Lehmann and Flury 1943], a value of about 2,000 ppm would have been appropriate. However, the revised IDLH for diacetone alcohol is 1,800 ppm based strictly on safety considerations (i.e., being 10% of the lower explosive limit of 1.8%).
**REFERENCES:**
1. Gross E [?]. Unpublished. [From Lehmann KB, Flury F, eds. [1943]. Toxicology and hygiene of industrial solvents. Translated by E. King and H.F. Smyth, Jr. Baltimore, MD: Williams & Wilkins Company, pp. 245­246.]
2. Lehmann KB, Flury F, eds. [1943]. Toxicology and hygiene of industrial solvents. Translated by E. King and H.F. Smyth, Jr. Baltimore, MD: Williams & Wilkins Company, pp. 245­246.
3. Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 1752.
4. Silverman L, Schulte HF, First WW [1946]. Further studies on sensory response to certain industrial solvent vapors. J Ind Hyg Toxicol *28*:262­268.
5. Smyth HF Jr, Carpenter CP [1948]. Further experience with the range­finding test in the industrial toxicology laboratory. J Ind Hyg Toxicol *30*(1):63­68.
6. Walton DC, Kehr EF, Louvenhart AS [1928]. A comparison of the pharmacological action of diacetone alcohol and acetone. J Pharmacol Exp Ther *33*:175­183.
7. Wenzel DG, Koff GY [1956]. Anticonvulsant properties of some alkyldiols, alkyldiones and related compounds. J Am Pharm Assoc, Scientific Edition *45*(10):669­672.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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