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sec-Amyl acetate																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 626-38-0
**NIOSH REL:** 125 ppm (650 mg/m3) TWA
**Current OSHA PEL:** 125 ppm (650 mg/m3) TWA
**1989 OSHA PEL:** Same as current PEL
**1993-1994 ACGIH TLV:** 125 ppm (665 mg/m3) TWA
**Description of substance:** Colorless liquid with a mild odor.
**LEL:** 1% (10% LEL, 1,000 ppm)
**Original (SCP) IDLH:** 9,000 ppm
**Basis for original (SCP) IDLH:** The chosen IDLH is based on the statement by ACGIH [1971] that 9,200 ppm was lethal to guinea pigs in 7 hours [Patty et al. 1936]. This is the only data on acute inhalation toxicity available on which to base the IDLH.
**Short-term exposure guidelines:** None developed
ACUTE TOXICITY DATA
**Lethal concentration data:**
AdjustedLC50
    LCLo
    
    0.5-hr
    DerivedSpecies
    Reference
    (ppm)
    (ppm)
    Time
    LC (CF)
    ValueG. pig
    Patty et al. 1936
    -----
    9,200
    7 hr
    22,080 ppm (2.4)
    2,208 ppmG. pig
    von Oettingen 1960
    -----
    10,000
    5 hr
    21,500 ppm (2.15)
    2,150 ppm**Human data:** It has been stated that exposure to 1,000 ppm for an hour may be expected to produce serious toxic effects [von Oettingen 1960].
 **Revised IDLH:** 1,000 ppm**Basis for revised IDLH:** The revised IDLH for sec-amyl acetate is 1,000 ppm based on acute inhalation toxicity data in humans [von Oettingen 1960] and the similarity of the toxic effects of sec-amyl acetate to those of n-amyl acetate (which also has a revised IDLH of 1,000 ppm).References:
ACGIH [1971]. sec-Amyl acetate. In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 13.
Patty FA, Yant WP, Schrenk HH [1936]. Acute response of guinea pigs to vapors of some new commercial organic compounds. XI. Secondary amyl acetate. Public Health Rep *51*(25):811-819.
von Oettingen WF [1960]. The aliphatic acids and their esters: toxicity and potential dangers. AMA Arch Ind Health *21*:40/28-77/65.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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