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ß-Chloroprene																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 126–99–8
**NIOSH REL:** 1 ppm (3.6 mg/m3) 15-minute CEILING; NIOSH considers ß-chloroprene to be a potential occupational carcinogen as defined by the OSHA carcinogen policy [29 CFR 1990].
**Current OSHA PEL:** 25 ppm (90 mg/m3) TWA [skin]
**1989 OSHA PEL:** 10 ppm (35 mg/m3) TWA [skin]
**1993-1994 ACGIH TLV:** 10 ppm (36 mg/m3) TWA [skin]
**Description of Substance:** Colorless liquid with a pungent, ether-like odor.
**LEL:** . . 4.0% (10% LEL, 4,000 ppm)
**Original (SCP) IDLH:** 400 ppm
**Basis for original (SCP) IDLH:** The chosen IDLH is based on the statement by Patty [1963] that no mice died from a 1-hour exposure to 277 ppm, but all mice died from a 1-hour exposure to 829.2 ppm [von Oettingen et al. 1936].
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50** **(ppm)**
    **LCLo** **(ppm)**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived** **value**Rat MouseRabbitCat
    Izmerov et al. 1982 von Oettingen et al. 1936von Oettingen et al. 1936von Oettingen et al. 1936
    3,207 LC100: 829----------
    ----- -----1,052350
    4 hr 1 hr8 hr8 hr
    6,414 ppm (2.0) 1,036 ppm (1.25)2,629 ppm (2.5)876 ppm (2.5)
    641 ppm 104 ppm263 ppm88 ppm
 **Human data:** Exposure to 973 ppm has resulted in nausea and giddiness in volunteers in 10 to 15 minutes [Nystrom 1948]. Extreme fatigue and unbearable chest pain has occurred following a month of exposure to concentrations ranging from 56 to 334 ppm [Nystrom 1948].
 
 **Revised IDLH:** 300 ppm **Basis for revised IDLH:** The revised IDLH for ß-chloroprene is 300 ppm based on acute inhalation toxicity data in humans [Nystrom 1948]. [Note: NIOSH recommends as part of its carcinogen policy that the "most protective" respirators be worn for ß-chloroprene at concentrations above 1 ppm.]
**REFERENCES:**
1. Izmerov NF, Sanotsky IV, Sidorov KK [1982]. Toxicometric parameters of industrial toxic chemicals under single exposure. Moscow, Russia: Centre of International Projects, GKNT, p. 38.
2. Nystrom AE [1948]. Health hazards in the chloroprene rubber industry and their prevention. A clinical and experimental study, with special reference to chloroprene and its oxidation and polymerization products. Acta Med Scand *123* (Suppl 219):5-125.
3. Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 1320.
4. von Oettingen WF, Hueper WC, Deichmann-Grubler W, Wiley FH [1936]. 2-Chlorobutadiene (chloroprene): its toxicity and pathology and the mechanism of its action. J Ind Hyg Toxicol *18* (4):247-249.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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