----

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| T | ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 |
|---|--------------------------------------------------------------------------------------|

| £ | TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 |
|--------|------------------------------------------------------------------------------------------|

| Delaware                                                       | 77-0397908                                           |
|----------------------------------------------------------------|------------------------------------------------------|
| (State or Other Jurisdiction of Incorporation or Organization) | (IRS Employer Identification Number)                 |
|                                                           |                                                 |
| 1263 East Arques Avenue                                        |                                                 |
| Sunnyvale, California 94085                                    | (408) 764-2000                                       |
| (Address of Principal Executive Offices Including Zip Code)    | (Registrant's Telephone Number, Including Area Code) |

| Class:     Common Stock, $0.001 Par Value | Name of Each Exchange on Which Registered: | NASDAQ Global Select Market |
|--------------------------------------------------------------------|--------------------------------------------|-----------------------------|

| Indicate by check mark if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act. | £Yes   TNo |
|-------------------------------------------------------------------------------------------------------------------------|--------------------------------|

| Indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or Section 15(d) of the Act. | £Yes   TNo |
|------------------------------------------------------------------------------------------------------------------------------|--------------------------------|

|   | TYes £No |
|--------|---------------|

|   | T |
|--------|---|

| £ Large accelerated filer | T Accelerated filer | £ Non-accelerated filer (Do not check if a smaller reporting company) | £ Smaller Reporting Company |
|--------------------------------|--------------------------|----------------------------------------------------------------------------|----------------------------------|

| Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act). | £Yes  TNo |
|------------------------------------------------------------------------------------------------------------------|--------------------------|

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----

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----

| ExhibitNumber |   | Description of Document                                                                                                                                                                                           |
|---------------|--------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| *2.1          | (7)    | Agreement and Plan of Merger, dated as of November 12, 2004, by and among Symyx Technologies, Inc., and  IntelliChem, Inc.                                                                              |
| #2.2          | (20)   | Sale Agreement by and among Elsevier Inc., Elsevier Swiss Holdings S.A., Elsevier Japan KK, Elsevier Limited and MDL Information Systems (UK) Limited as sellers and Symyx Technologies, Inc.  as buyer |
| 3.1           | (1)    | Amended and Restated Certificate of Incorporation                                                                                                                                                                 |
| 3.2           | (18)   | Amended and Restated Bylaws of Symyx Technologies, Inc.                                                                                                                                                           |
| 3.3           | (8)    | Certificate of Amendment to the Amended and Restated Bylaws of Symyx Technologies, Inc.                                                                                                                           |
| 4.1           | (2)    | Specimen Common Stock Certificate                                                                                                                                                                                 |
| **10.1        | (9)    | Synthematix, Inc.  Amended and Restated 2000 Equity Compensation Plan and forms of agreements thereunder                                                                                                |
| **10.2        | (2)    | 1996 Stock Plan and forms of agreements thereunder                                                                                                                                                                |
| **10.3        | (11)   | Amended and Restated 1997 Stock Plan and forms of agreements thereunder                                                                                                                                           |
| **10.4        | (2)    | 1999 Employee Stock Purchase Plan                                                                                                                                                                                 |
| **10.8        | (16)   | Form of Restricted Stock Agreement under the Symyx Technologies, Inc.  1997 Stock Plan                                                                                                                  |
| 10.10         | (2)    | Collaborative Research and License Agreement dated January 1, 1999 between Symyx and The Dow Chemical Company                                                                                                     |
| 10.11         | (2)    | License Agreement dated June 22, 1995 between Symyx and Lawrence Berkeley Laboratory, on behalf of The Regents of the University of California                                                                    |
| 10.13         | (3)    | Lease by and between East Arques Sunnyvale, LLC and Symyx Technologies, Inc.  for the premises at 1263 E.  Arques, Sunnyvale, California, and addenda and inserts thereto                     |
| **10.14       | (4)    | 2001 Nonstatutory Stock Option Plan                                                                                                                                                                               |
| *10.16        | (5)    | Alliance, Technology Transfer, and License Agreement effective April 1, 2003 between Symyx Technologies, Inc., Symyx Discovery Tools, Inc.  and ExxonMobil Research and Engineering Company             |
| *10.17        | (8)    | Alliance Agreement dated December 16, 2004 between Symyx Technologies, Inc., Symyx Discovery Tools, Inc.  and The Dow Chemical Company                                                                  |
| **10.18       | (8)    | 2003 IntelliChem, Inc.  Stock Option Plan and forms of agreements thereunder                                                                                                                            |
| 10.19         | (10)   | Lease by and between Oakmead Ventures LLC and Symyx Technologies, Inc.  for the premises at 415 Oakmead Parkway, Sunnyvale, California, and addenda and inserts thereto                                 |
| **10.20       | (16)   | Form of Restricted Stock Unit Agreement under the Symyx Technologies, Inc.  1997 Stock Plan.                                                                                                            |

----

| ExhibitNumber |   | Description of Document                                                                                                                                                                                                                                    |
|---------------|--------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| 10.21         | (13)   | First Amendment to Lease dated  January 19, 2007 by and between Symyx Technologies, Inc.  and East Arques Sunnyvale,  LLC for the premises at 1263 East Arques Avenue, Sunnyvale, California and addenda and inserts thereto |
| **10.23       | (17)   | Symyx Technologies, Inc.  Executive Change in Control and Severance Benefit Plan                                                                                                                                                                 |
| **10.26       | (21)   | Form of Restricted Stock Unit Award under the Symyx Technologies, Inc.  2007 Stock Incentive Plan                                                                                                                                                |
| **10.27       | (21)   | Form of Director and Executive Officer Indemnification Agreement                                                                                                                                                                                           |
| 10.28         | (22)   | Credit Agreement, dated as of September 28, 2007, by and among Symyx Technologies, Inc.  as borrower, Bank of America, N.A.  as administrative agent and L/C issuer, and the other lenders from time to time party thereto             |
| **10.29       | (23)   | Form of Stock Option Agreement under the Symyx Technologies, Inc.  2007 Stock Incentive Plan                                                                                                                                                     |
| **10.30       | (24)   | Form of Stock Option Agreement under the Symyx Technologies, Inc.  2001 Nonstatutory Stock Option Plan                                                                                                                                           |
| **10.31       | (25)   | 2007 Stock Incentive Plan, as amended                                                                                                                                                                                                                      |
| *10.32        | (26)   | Supplemental Agreement, by and between Symyx Technologies, Inc.  and The Dow Chemical Company                                                                                                                                                    |
| **10.34       | (27)   | Fiscal Year 2008/2009 Base Salaries and Target Bonus Payouts for Executive Officers                                                                                                                                                                        |
| **10.35       | (12)   | Symyx Technologies, Inc.’s Offer Letter to Rex S.  Jackson Dated January 30, 2007                                                                                                                                                          |
| **10.36       | (12)   | Symyx Technologies, Inc.’s Offer Letter to Timothy E.  Campbell Dated February 6, 2007                                                                                                                                                     |
| **10.37       | (12)   | Symyx Technologies, Inc.’s Offer Letter to Richard Boehner Dated March 13, 2007                                                                                                                                                                      |
| **10.38       | (14)   | Consulting and Independent Contractor Services Agreement between Symyx Technologies, Inc.  and David Hill                                                                                                                                        |
| **10.39       | (14)   | Symyx Technologies, Inc.  Executive Change in Control and Severance Benefit Plan Confirmation by Dr.  W.  Henry Weinberg                                                                                                     |
| **10.40       | (14)   | Symyx Technologies, Inc.’s Offer Letter to Dr.  W.  Henry Weinberg Dated March 6, 1996                                                                                                                                           |
| **10.41       | (14)   | Symyx Technologies, Inc.’s Offer Letter to Mr.  Steven D.  Goldby Dated April 28, 1998                                                                                                                                           |
| **10.42       | (19)   | First Amendment to the Consulting and Independent Contractor and Service Agreement and Work Orders between Symyx Technologies, Inc.  and David C.  Hill                                                                                |
| 10.44         | (28)   | Amendment to Credit Agreement, dated as of March 12, 2009, among Symyx Technologies, Inc., each lender from time to time party thereto, and Bank of America, N.A.  as administrative agent and L/C issuer                                        |
| 14            | (6)    | Symyx Technologies, Inc.  Code of Conduct and Ethics                                                                                                                                                                                             |
| 21            | (28)   | List of Subsidiaries                                                                                                                                                                                                                                       |
| 23.1          | (28)   | Consent of Independent Registered Public Accounting Firm                                                                                                                                                                                                   |
| 24.1          |   | Power of Attorney (reference is made to the signature page of this report)                                                                                                                                                                                 |
| 31.1          | (28)   | Certification of Chief Executive Officer pursuant to Rules 13a-14(a) and 15d-14(a) promulgated under the Securities Exchange Act of 1934, as amended, as adopted pursuant to Section 302(a) of the Sarbanes-Oxley Act of 2002.                             |
| 31.2          | (28)   | Certification of Chief Financial Officer pursuant to Rules 13a-14(a) and 15d-14(a) promulgated under the Securities Exchange Act of 1934, as amended, as adopted pursuant to Section 302(a) of the Sarbanes-Oxley Act of 2002.                             |
| 32.1          | (28)   | Certification of Chief Executive Officer pursuant to 18 U.S.C.  Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.                                                                                              |
| 32.2          | (28)   | Certification of Chief Financial Officer pursuant to 18 U.S.C.  Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.                                                                                              |

| (1) | Incorporated by reference to the same number exhibit filed with Registrant’s Quarterly Report on Form 10-Q for the period ended June 30, 2003. |
|-----|------------------------------------------------------------------------------------------------------------------------------------------------------|

| (2) | Incorporated by reference to the same number exhibit filed with Registrant’s Registration Statement on Form S-1 (File No.  333-87453), as amended. |
|-----|--------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (3) | Incorporated by reference to the same number exhibit filed with Registrant’s Annual Report on Form 10-K for the year ended December 31, 2000. |
|-----|-----------------------------------------------------------------------------------------------------------------------------------------------------|

----

| (4) | Incorporated by reference to exhibit 4.1 filed with Registrant’s Registration Statement on Form S-8 (File No.  333-82166). |
|-----|--------------------------------------------------------------------------------------------------------------------------------------------|

| (5) | Incorporated by reference to the same number exhibit filed with Registrant’s Quarterly Report on Form 10-Q for the period ended September 30, 2003. |
|-----|-----------------------------------------------------------------------------------------------------------------------------------------------------------|

| (6) | Incorporated by reference to the same number exhibit filed with Registrant’s Annual Report on Form 10-K for the year ended December 31, 2003. |
|-----|-----------------------------------------------------------------------------------------------------------------------------------------------------|

| (7) | Incorporated by reference to the same number exhibit filed with Registrant’s Current Report on Form 8-K on December 2, 2004. |
|-----|------------------------------------------------------------------------------------------------------------------------------------|

| (8) | Incorporated by reference to the same number exhibit filed with Registrant’s Annual Report on Form 10-K for the year ended December 31, 2004. |
|-----|-----------------------------------------------------------------------------------------------------------------------------------------------------|

| (9) | Incorporated by reference to the same number exhibit filed with Registrant’s Quarterly Report on Form 10-Q for the period ended March 31, 2005. |
|-----|-------------------------------------------------------------------------------------------------------------------------------------------------------|

| (10) | Incorporated by reference to the same number exhibit filed with Registrant’s Current Report on Form 8-K on November 15, 2005. |
|------|-------------------------------------------------------------------------------------------------------------------------------------|

| (11) | Incorporated by reference to the same number exhibit filed with Registrant’s Annual Report on Form 10-K for the year ended December 31, 2005. |
|------|-----------------------------------------------------------------------------------------------------------------------------------------------------|

| (12) | Incorporated by reference to the same number exhibit filed with Registrant’s Quarterly Report on Form 10-Q for the period ended March 31, 2008. |
|------|-------------------------------------------------------------------------------------------------------------------------------------------------------|

| (13) | Incorporated by reference to the same number exhibit filed with Registrant’s Current Report on Form 8-K on January 19, 2007. |
|------|------------------------------------------------------------------------------------------------------------------------------------|

| (14) | Incorporated by reference to the same number exhibit filed with Registrant’s Quarterly Report on Form 10-Q for the period ended June 30, 2008. |
|------|------------------------------------------------------------------------------------------------------------------------------------------------------|

| (15) | Incorporated by reference to the same number exhibit filed with Registrant’s Current Report on Form 8-K on February 14, 2007. |
|------|-------------------------------------------------------------------------------------------------------------------------------------|

| (16) | Incorporated by reference to the same number exhibit filed with the Registrant’s Annual Report on Form 10-K for the year ended December 31, 2006. |
|------|---------------------------------------------------------------------------------------------------------------------------------------------------------|

| (17) | Incorporated by reference to the same number exhibit filed with Registrant’s Quarterly Report on Form 10-Q for the period ended March 31, 2007. |
|------|-------------------------------------------------------------------------------------------------------------------------------------------------------|

| (18) | Incorporated by reference to the same number exhibit filed with Registrant’s Current Report on Form 8-K filed on December 1, 2008 (SEC File No.  000-27765). |
|------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (19) | Incorporated by reference to the same number exhibit filed with Registrant’s Current Report on Form 8-K on November 7, 2008. |
|------|------------------------------------------------------------------------------------------------------------------------------------|

| (20) | Incorporated by reference to Exhibit 10.25 filed with Registrant’s Current Report on Form 8-K on August 15, 2007. |
|------|-------------------------------------------------------------------------------------------------------------------------|

| (21) | Incorporated by reference to the same number exhibit filed with Registrant’s Current Report on Form 8-K on September 4, 2007. |
|------|-------------------------------------------------------------------------------------------------------------------------------------|

| (22) | Incorporated by reference to the same number exhibit filed with Registrant’s Current Report on Form 8-K on October 4, 2007. |
|------|-----------------------------------------------------------------------------------------------------------------------------------|

| (23) | Incorporated by reference to the same number exhibit filed with Registrant’s Current Report on Form 8-K on November 8, 2007. |
|------|------------------------------------------------------------------------------------------------------------------------------------|

| (24) | Incorporated by reference to Exhibit 10.7 filed with Registrant’s Quarterly Report on Form 10-Q for the period ended September 30, 2007. |
|------|------------------------------------------------------------------------------------------------------------------------------------------------|

| (25) | Incorporated by reference to Exhibit 99.1 filed with Registrant’s Registration Statement on Form S-8 filed on August 8, 2008 (SEC File No.  333-152893). |
|------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (26) | Incorporated by reference to the same number exhibit filed with Registrant’s Annual Report on Form 10-K for the period ended December 31, 2007. |
|------|-------------------------------------------------------------------------------------------------------------------------------------------------------|

| (27) | Incorporated by reference to Item 5.02 of the Registrant’s Current Report on Form 8-K filed on February 24, 2009. |
|------|-------------------------------------------------------------------------------------------------------------------------|

----

| (28) | Incorporated by reference to the same number exhibit filed with Registrant’s Annual Report on Form 10-K for the period ended December 31, 2008. |
|------|-------------------------------------------------------------------------------------------------------------------------------------------------------|

----

|                           | SYMYX TECHNOLOGIES, INC.      |
|--------------------------------|-------------------------------|
|                           |    (Registrant)     |
|                           |                          |   |
|                           |                          |   |
|                           |                          |   |
| Date:  June 10, 2009 | /s/ Isy Goldwasser            |   |
|                           | Isy Goldwasser                |
|                           | Chief Executive Officer       |
|                           | (Principal Executive Officer) |
|                           |                          |   |
|                           |                          |   |
| Date:  June 10, 2009 | /s/ Rex S. Jackson            |   |
|                           | Rex S. Jackson                |
|                           | Executive Vice President,     |
|                           | Chief Financial Officer       |
|                           | (Principal Financial Officer) |

----

| ExhibitNumber |   | Description of Document                                                                                                                                                                                                                                    |
|---------------|--------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| *2.1          | (7)    | Agreement and Plan of Merger, dated as of November 12, 2004, by and among Symyx Technologies, Inc., and  IntelliChem, Inc.                                                                                                                       |
| #2.2          | (20)   | Sale Agreement by and among Elsevier Inc., Elsevier Swiss Holdings S.A., Elsevier Japan KK, Elsevier Limited and MDL Information Systems (UK) Limited as sellers and Symyx Technologies, Inc.  as buyer                                          |
| 3.1           | (1)    | Amended and Restated Certificate of Incorporation                                                                                                                                                                                                          |
| 3.2           | (18)   | Amended and Restated Bylaws of Symyx Technologies, Inc.                                                                                                                                                                                                    |
| 3.3           | (8)    | Certificate of Amendment to the Amended and Restated Bylaws of Symyx Technologies, Inc.                                                                                                                                                                    |
| 4.1           | (2)    | Specimen Common Stock Certificate                                                                                                                                                                                                                          |
| **10.1        | (9)    | Synthematix, Inc.  Amended and Restated 2000 Equity Compensation Plan and forms of agreements thereunder                                                                                                                                         |
| **10.2        | (2)    | 1996 Stock Plan and forms of agreements thereunder                                                                                                                                                                                                         |
| **10.3        | (11)   | Amended and Restated 1997 Stock Plan and forms of agreements thereunder                                                                                                                                                                                    |
| **10.4        | (2)    | 1999 Employee Stock Purchase Plan                                                                                                                                                                                                                          |
| **10.8        | (16)   | Form of Restricted Stock Agreement under the Symyx Technologies, Inc.  1997 Stock Plan                                                                                                                                                           |
| 10.10         | (2)    | Collaborative Research and License Agreement dated January 1, 1999 between Symyx and The Dow Chemical Company                                                                                                                                              |
| 10.11         | (2)    | License Agreement dated June 22, 1995 between Symyx and Lawrence Berkeley Laboratory, on behalf of The Regents of the University of California                                                                                                             |
| 10.13         | (3)    | Lease by and between East Arques Sunnyvale, LLC and Symyx Technologies, Inc.  for the premises at 1263 E.  Arques, Sunnyvale, California, and addenda and inserts thereto                                                              |
| **10.14       | (4)    | 2001 Nonstatutory Stock Option Plan                                                                                                                                                                                                                        |
| *10.16        | (5)    | Alliance, Technology Transfer, and License Agreement effective April 1, 2003 between Symyx Technologies, Inc., Symyx Discovery Tools, Inc. and ExxonMobil Research and Engineering Company                                                                 |
| *10.17        | (8)    | Alliance Agreement dated December 16, 2004 between Symyx Technologies, Inc., Symyx Discovery Tools, Inc.  and The Dow Chemical Company                                                                                                           |
| **10.18       | (8)    | 2003 IntelliChem, Inc.  Stock Option Plan and forms of agreements thereunder                                                                                                                                                                     |
| 10.19         | (10)   | Lease by and between Oakmead Ventures LLC and Symyx Technologies, Inc.  for the premises at 415 Oakmead Parkway, Sunnyvale, California, and addenda and inserts thereto                                                                          |
| **10.20       | (16)   | Form of Restricted Stock Unit Agreement under the Symyx Technologies, Inc.  1997 Stock Plan.                                                                                                                                                     |
| 10.21         | (13)   | First Amendment to Lease dated  January 19, 2007 by and between Symyx Technologies, Inc.  and East Arques Sunnyvale,  LLC for the premises at 1263 East Arques Avenue, Sunnyvale, California and addenda and inserts thereto |
| **10.23       | (17)   | Symyx Technologies, Inc.  Executive Change in Control and Severance Benefit Plan                                                                                                                                                                 |
| **10.26       | (21)   | Form of Restricted Stock Unit Award under the Symyx Technologies, Inc.  2007 Stock Incentive Plan                                                                                                                                                |
| **10.27       | (21)   | Form of Director and Executive Officer Indemnification Agreement                                                                                                                                                                                           |
| 10.28         | (22)   | Credit Agreement, dated as of September 28, 2007, by and among Symyx Technologies, Inc.  as borrower, Bank of America, N.A.  as administrative agent and L/C issuer, and the other lenders from time to time party thereto             |
| **10.29       | (23)   | Form of Stock Option Agreement under the Symyx Technologies, Inc. 2007 Stock Incentive Plan                                                                                                                                                                |
| **10.30       | (24)   | Form of Stock Option Agreement under the Symyx Technologies, Inc. 2001 Nonstatutory Stock Option Plan                                                                                                                                                      |
| **10.31       | (25)   | 2007 Stock Incentive Plan, as amended                                                                                                                                                                                                                      |
| *10.32        | (26)   | Supplemental Agreement, by and between Symyx Technologies, Inc. and The Dow Chemical Company                                                                                                                                                               |
| **10.34       | (27)   | Fiscal Year 2008/2009 Base Salaries and Target Bonus Payouts for Executive Officers                                                                                                                                                                        |
| **10.35       | (12)   | Symyx Technologies, Inc.’s Offer Letter to Rex S.  Jackson Dated January 30, 2007                                                                                                                                                          |
| **10.36       | (12)   | Symyx Technologies, Inc.’s Offer Letter to Timothy E.  Campbell Dated February 6, 2007                                                                                                                                                     |
| **10.37       | (12)   | Symyx Technologies, Inc.’s Offer Letter to Richard Boehner Dated March 13, 2007                                                                                                                                                                      |
| **10.38       | (14)   | Consulting and Independent Contractor Services Agreement between Symyx Technologies, Inc.  and David Hill                                                                                                                                        |
| **10.39       | (14)   | Symyx Technologies, Inc.  Executive Change in Control and Severance Benefit Plan Confirmation by Dr.  W.  Henry Weinberg                                                                                                     |
| **10.40       | (14)   | Symyx Technologies, Inc.’s Offer Letter to Dr.  W.  Henry Weinberg Dated March 6, 1996                                                                                                                                           |
| **10.41       | (14)   | Symyx Technologies, Inc.’s Offer Letter to Mr.  Steven D.  Goldby Dated April 28, 1998                                                                                                                                           |
| **10.42       | (19)   | First Amendment to the Consulting and Independent Contractor and Service Agreement and Work Orders between Symyx Technologies, Inc.  and David C.  Hill                                                                                |

----

| ExhibitNumber |   | Description of Document                                                                                                                                                                                                        |
|---------------|--------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| 10.44         | (28)   | Amendment to Credit Agreement, dated as of March 12, 2009, among Symyx Technologies, Inc., each lender from time to time party thereto, and Bank of America, N.A. as administrative agent and L/C issuer                       |
| 14            | (6)    | Symyx Technologies, Inc.  Code of Conduct and Ethics                                                                                                                                                                 |
| 21            | (28)   | List of Subsidiaries                                                                                                                                                                                                           |
| 23.1          | (28)   | Consent of Independent Registered Public Accounting Firm                                                                                                                                                                       |
| 24.1          |   | Power of Attorney (reference is made to the signature page of this report)                                                                                                                                                     |
| 31.1          | (28)   | Certification of Chief Executive Officer pursuant to Rules 13a-14(a) and 15d-14(a) promulgated under the Securities Exchange Act of 1934, as amended, as adopted pursuant to Section 302(a) of the Sarbanes-Oxley Act of 2002. |
| 31.2          | (28)   | Certification of Chief Financial Officer pursuant to Rules 13a-14(a) and 15d-14(a) promulgated under the Securities Exchange Act of 1934, as amended, as adopted pursuant to Section 302(a) of the Sarbanes-Oxley Act of 2002. |
| 32.1          | (28)   | Certification of Chief Executive Officer pursuant to 18 U.S.C.  Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.                                                                  |
| 32.2          | (28)   | Certification of Chief Financial Officer pursuant to 18 U.S.C.  Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.                                                                  |

| (1) | Incorporated by reference to the same number exhibit filed with Registrant’s Quarterly Report on Form 10-Q for the period ended June 30, 2003. |
|-----|------------------------------------------------------------------------------------------------------------------------------------------------------|

| (2) | Incorporated by reference to the same number exhibit filed with Registrant’s Registration Statement on Form S-1 (File No.  333-87453), as amended. |
|-----|--------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (3) | Incorporated by reference to the same number exhibit filed with Registrant’s Annual Report on Form 10-K for the year ended December 31, 2000. |
|-----|-----------------------------------------------------------------------------------------------------------------------------------------------------|

| (4) | Incorporated by reference to exhibit 4.1 filed with Registrant’s Registration Statement on Form S-8 (File No.  333-82166). |
|-----|--------------------------------------------------------------------------------------------------------------------------------------------|

| (5) | Incorporated by reference to the same number exhibit filed with Registrant’s Quarterly Report on Form 10-Q for the period ended September 30, 2003. |
|-----|-----------------------------------------------------------------------------------------------------------------------------------------------------------|

| (6) | Incorporated by reference to the same number exhibit filed with Registrant’s Annual Report on Form 10-K for the year ended December 31, 2003. |
|-----|-----------------------------------------------------------------------------------------------------------------------------------------------------|

| (7) | Incorporated by reference to the same number exhibit filed with Registrant’s Current Report on Form 8-K on December 2, 2004. |
|-----|------------------------------------------------------------------------------------------------------------------------------------|

| (8) | Incorporated by reference to the same number exhibit filed with Registrant’s Annual Report on Form 10-K for the year ended December 31, 2004. |
|-----|-----------------------------------------------------------------------------------------------------------------------------------------------------|

| (9) | Incorporated by reference to the same number exhibit filed with Registrant’s Quarterly Report on Form 10-Q for the period ended March 31, 2005. |
|-----|-------------------------------------------------------------------------------------------------------------------------------------------------------|

| (10) | Incorporated by reference to the same number exhibit filed with Registrant’s Current Report on Form 8-K on November 15, 2005. |
|------|-------------------------------------------------------------------------------------------------------------------------------------|

| (11) | Incorporated by reference to the same number exhibit filed with Registrant’s Annual Report on Form 10-K for the year ended December 31, 2005. |
|------|-----------------------------------------------------------------------------------------------------------------------------------------------------|

| (12) | Incorporated by reference to the same number exhibit filed with Registrant’s Quarterly Report on Form 10-Q for the period ended March 31, 2008. |
|------|-------------------------------------------------------------------------------------------------------------------------------------------------------|

| (13) | Incorporated by reference to the same number exhibit filed with Registrant’s Current Report on Form 8-K on January 19, 2007. |
|------|------------------------------------------------------------------------------------------------------------------------------------|

----

| (14) | Incorporated by reference to the same number exhibit filed with Registrant’s Quarterly Report on Form 10-Q for the period ended June 30, 2008. |
|------|------------------------------------------------------------------------------------------------------------------------------------------------------|

| (15) | Incorporated by reference to the same number exhibit filed with Registrant’s Current Report on Form 8-K on February 14, 2007. |
|------|-------------------------------------------------------------------------------------------------------------------------------------|

| (16) | Incorporated by reference to the same number exhibit filed with the Registrant’s Annual Report on Form 10-K for the year ended December 31, 2006. |
|------|---------------------------------------------------------------------------------------------------------------------------------------------------------|

| (17) | Incorporated by reference to the same number exhibit filed with Registrant’s Quarterly Report on Form 10-Q for the period ended March 31, 2007. |
|------|-------------------------------------------------------------------------------------------------------------------------------------------------------|

| (18) | Incorporated by reference to the same number exhibit filed with Registrant’s Current Report on Form 8-K filed on December 1, 2008 (SEC File No.  000-27765). |
|------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (19) | Incorporated by reference to the same number exhibit filed with Registrant’s Current Report on Form 8-K on November 7, 2008. |
|------|------------------------------------------------------------------------------------------------------------------------------------|

| (20) | Incorporated by reference to Exhibit 10.25 filed with Registrant’s Current Report on Form 8-K on August 15, 2007. |
|------|-------------------------------------------------------------------------------------------------------------------------|

| (21) | Incorporated by reference to the same number exhibit filed with Registrant’s Current Report on Form 8-K on September 4, 2007. |
|------|-------------------------------------------------------------------------------------------------------------------------------------|

| (22) | Incorporated by reference to the same number exhibit filed with Registrant’s Current Report on Form 8-K on October 4, 2007. |
|------|-----------------------------------------------------------------------------------------------------------------------------------|

| (23) | Incorporated by reference to the same number exhibit filed with Registrant’s Current Report on Form 8-K on November 8, 2007. |
|------|------------------------------------------------------------------------------------------------------------------------------------|

| (24) | Incorporated by reference to Exhibit 10.7 filed with Registrant’s Quarterly Report on Form 10-Q for the period ended September 30, 2007. |
|------|------------------------------------------------------------------------------------------------------------------------------------------------|

| (25) | Incorporated by reference to Exhibit 99.1 filed with Registrant’s Registration Statement on Form S-8 filed on August 8, 2008 (SEC File No.  333-152893). |
|------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (26) | Incorporated by reference to the same number exhibit filed with Registrant’s Annual Report on Form 10-K for the period ended December 31, 2007. |
|------|-------------------------------------------------------------------------------------------------------------------------------------------------------|

| (27) | Incorporated by reference to Item 5.02 of the Registrant’s Current Report on Form 8-K filed on February 24, 2009. |
|------|-------------------------------------------------------------------------------------------------------------------------|

| (28) | Incorporated by reference to the same number exhibit filed with Registrant’s Annual Report on Form 10-K for the period ended December 31, 2008. |
|------|-------------------------------------------------------------------------------------------------------------------------------------------------------|

----

| ExhibitNumber |   | Description of Document                                                                                                                                                                                                        |
|---------------|--------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| 31.1          |   | Certification of Chief Executive Officer pursuant to Rules 13a-14(a) and 15d-14(a) promulgated under the Securities Exchange Act of 1934, as amended, as adopted pursuant to Section 302(a) of the Sarbanes-Oxley Act of 2002. |
| 31.2          |   | Certification of Chief Financial Officer pursuant to Rules 13a-14(a) and 15d-14(a) promulgated under the Securities Exchange Act of 1934, as amended, as adopted pursuant to Section 302(a) of the Sarbanes-Oxley Act of 2002. |

----