Prescription Opioid and Benzodiazepine 

Medications and Occupational Safety and Health

Information for Employers and Healthcare Providers

Prescription opioid medications intended for pain management and 

prescription benzodiazepines for conditions such as anxiety or insomnia, when used alone or together, often have side effects that 

can affect workers’ health and safety. In addition, some occupational 

factors, such as work-related motor vehicle crashes, falls, other 

injuries and job stress, have the potential to increase the chances 

that a worker is given a prescription for an opioid or benzodiazepine 

[Kowalski-McGraw et al. 2017]. 

The Centers for Disease Control and Prevention (CDC) has developed 

resources for improving communication between clinicians and 

patients about the risks and benefits of opioid therapy for pain, 

improving the safety and effectiveness of pain treatment, and reducing the risks associated with long-term opioid therapy, including 

opioid use disorder (a problematic pattern of opioid use that causes 

significant impairment or distress), overdose, and death. In some 

cases, prescriptions could be an initial or single one. In other cases, 

an opioid and/or benzodiazepine prescription could be the starting 

point for increasing and/or long-term use. 

This fact sheet summarizes findings from the scientific literature 

[Kowalski-McGraw et al. 2017] and provides information from relevant CDC and National Institute for Occupational Safety and Health 

(NIOSH) publications for employers and healthcare providers about 

the prescription use of opioids and benzodiazepines.

What are some side effects of prescription 

opioid or benzodiazepine use?

 Sedation: feelings of sleepiness and dizziness can happen 

when starting or continuing to take these medications. 

Sedation may lead to diminished alertness, responsiveness, 

impaired decision-making, or injury.

 Movement and coordination: the use of prescription opioids 

and benzodiazepines is associated with both physical and 

cognitive impairment. Physical and cognitive impairment is 

a slowing-down of the coordination of thoughts and physical movements, which can be associated with an increased 

risk for errors and injuries.

Centers for Disease Control

and Prevention

National Institute for Occupational 

Safety and Health
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Prescription Opioid and Benzodiazepine Medications and Occupational Safety and Health

 Memory: certain benzodiazepines may lead to short and long-term memory 

problems. Memory issues can also occur with long-term prescription opioid 

use. 

 Strength and posture: prescription opioids and benzodiazepines may impair 

a person’s ability to control their posture and may lead to falls. The prescription use of opioids and benzodiazepines among older adults is associated with an increased risk of falls and hip fractures from falls.

What are some occupational factors associated with the 

use of prescription opioids or benzodiazepines?

 Ergonomic hazards (such as heavy manual labor) leading to injuries, or 

repetitive use of the hands leading to other chronic painful conditions, 

might be treated with both of these medications. 

 Risky workplace conditions that lead to injury, such as slip, trip, or fall hazards, 

or heavy physical workloads can be associated with prescription opioid use. 

 Factors such as job insecurity, high-demand/low-control jobs, and workplace bullying are associated with anxiety disorder and depression [KowalskiMcGraw et al. 2017], which may be treated with prescription benzodiazepine medication.

How can the use of prescription opioids or 

benzodiazepines affect people at work?

 The use of prescription opioid and/or benzodiazepine drugs may negatively 

affect the performance of safety-sensitive tasks, such as driving or operating machinery.

 The use of opioids, even when taken as prescribed, is linked to risky driving 

behaviors and a higher risk of motor vehicle crashes. 

 The use of prescription opioids or benzodiazepines may increase the risk of 

falls among workers, a common cause of workplace injuries. 

 The use of prescription opioid or benzodiazepine drugs can decrease performance in tasks that require brain-eye-hand coordination. Work-related 

fatigue (for example, from shiftwork or long work hours) could worsen this 

performance loss.

What might healthcare professionals keep in mind?

 Consult currently available resources regarding recommendations pertaining to prescribing opioid pain medication or benzodiazepines, including 

the following [CDC 2016a,b, 2019]: 

o CDC Guideline for Prescribing Opioids for Chronic Pain

o CDC handout: Guideline for Prescribing Opioids for Chronic Pain: 

Promoting Patient Care and Safety
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Prescription Opioid and Benzodiazepine Medications and Occupational Safety and Health

o CDC webpage: Improve Opioid Prescribing

 Nonpharmacologic therapy and non-opioid pharmacologic therapy are 

preferred for chronic pain outside of active cancer, palliative, and end-oflife care.

 If opioid pain therapy is necessary, the lowest possible effective dosage 

should be prescribed to reduce the risk of opioid use disorder and overdose. 

Prescribers should refer to CDC guidelines.

o Exercise caution when prescribing opioids and monitor all patients closely. 

o Establish goals for pain and function.

o Discuss risks and benefits. 

 Use immediate-release opioids when starting.

o Use the lowest effective dosage.

o Prescribe a limited quantity for a short duration when managing acute 

pain: Three days’ supply or less will often be sufficient; more than 7 days’ 

supply will rarely be needed.

 Evaluate benefits and harms frequently.

 Use strategies to mitigate risk, e.g., education.

 Review prescription drug monitoring program data. 

 Avoid concurrent opioid or benzodiazepine prescribing whenever possible.

 Ensure that the patient is not receiving the same prescriptions from 

multiple providers. 

 Adhere to HIPAA guidelines for employee privacy.

 Consult other prescribing recommendations [see Hegmann et al. 2014].

 Offer or arrange treatment for opioid use disorder.

What might employers keep in mind? 

 Continue efforts to optimize worker safety, health, and well-being, and 

consider opportunities to reduce risks for work-related motor vehicle crashes, 

falls, other injuries and job stress. 

 Refer to the following NIOSH publications about the importance of 

preventing and reducing work-related hazards [NIOSH 1997, 1999, 2000, 

2015]:

o Elements of Ergonomics Programs

o Stress at Work

o Worker Deaths by Falls: A Summary of Surveillance Findings and 

Case Reports

o Preventing Work-Related Motor Vehicle Crashes 
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Prescription Opioid and Benzodiazepine Medications and Occupational Safety and Health

Acknowledgments

This document was prepared by Sudha P. Pandalai, MD, PhD; Paul A. Schulte, PhD; 

and Susan E. Afanuh, National Institute for Occupational Safety and Health. 

The authors acknowledge Michele Kowalski-McGraw, MD, MPH, and Judith 

Green-McKenzie, MD, MPH, for subject matter input.

Resources

More information about the use of opioids and other prescription drugs can be 

found at Kowalski-McGraw M, Green-McKenzie J, Pandalai S, Schulte P [2017]. 

Characterizing the interrelationships of prescription opioid and benzodiazepine medications with worker health and workplace hazards. J Occup Med 

59(11):1114–1126. http://dx.doi.org/10.1097/JOM.0000000000001154

References

CDC [2016a]. CDC guidelines for prescribing opioids for chronic pain: promoting patient care and safety. Atlanta, GA: Department of Health and Human 

Services, Centers for Disease Control and Prevention. https://www.cdc.gov/drugoverdose/pdf/Guidelines_At-A-Glance-a.pdf

CDC [2016b]. CDC guideline for prescribing opioids for chronic pain—United 

States, 2016. By Dowell D, Haegerich TM, Chou R. MMWR Recommendations 

and Reports 65(1):1–49. https://doi.org/10.15585/mmwr.rr6501e1er

CDC [2019]. Improve opioid prescribing. Atlanta, GA: Department of Health 

and Human Services, Centers for Disease Control and Prevention. https://www.

cdc.gov/drugoverdose/prevention/prescribing.html

Hegmann K, Weiss M, Bowden K, Branco F, DuBrueler K, Els C, Mandel S, 

McKinney D, Miguel R, Mueller K, Nadig R, Schaffer M, Studt L, Talmage J, Travis R, Winters T, Thiese M, Harris J [2014]. ACOEM practice guidelines: opioids 

and safety-sensitive work. J Occup Environ Med 56(7):e46–e53. http://dx.doi.

org/10.1097/JOM.0000000000000237

NIOSH [1997]. Elements of ergonomic programs: a primer based on workplace 

evaluations of musculoskeletal disorders. By Cohen A, Gjessing C, Fine L, 

Bernard B, McGlothlin J. Department of Health and Human Services, Centers for 

Disease Control and Prevention, National Institute for Occupational Safety and 

Health, DHHS (NIOSH) Publication 97–117. https://www.cdc.gov/niosh/docs/97-

117/pdfs/97-117.pdf?id=10.26616/NIOSHPUB97117

NIOSH [1999]. Stress at work. By Sauter S, Murphy L, Colligan M, Swanson 

N, Hurrell J, Scharf F, Sinclair R, Grubb P, Goldenhar L, Alterman T, Johnston J, 

Hamilton A, Tisdale J. Cincinnati, OH: U.S. Department of Health and Human 

Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication 99–101. https://www.

cdc.gov/niosh/docs/99-101/pdfs/99-101.pdf?id=10.26616/NIOSHPUB99101
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Prescription Opioid and Benzodiazepine Medications and Occupational Safety and Health

NIOSH [2000]. Worker deaths by falls. By Braddee R, Hause M, Pratt S. Cincinnati, OH: U.S. Department of Health and Human Services, Centers for Disease 

Control and Prevention, National Institute for Occupational Safety and Health, 

DHHS (NIOSH) Publication 2000–116. https://www.cdc.gov/niosh/docs/2000-

116/pdfs/2000-116.pdf?id=10.26616/NIOSHPUB2000116

NIOSH [2015]. Preventing work-related motor vehicle crashes. Department 

of Health and Human Services, Centers for Disease Control and Prevention, 

National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication 2015–111. https://www.cdc.gov/niosh/docs/2015-111/pdfs/2015-111.

pdf?id=10.26616/NIOSHPUB2015111

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Suggested Citation

NIOSH [2021]. Prescription opioid and benzodiazepine medications and occupational safety and health: information for employers and healthcare providers. 

By Pandalai SP, Schulte PA, Afanuh SE. Cincinnati, OH: U.S. Department of 

Health and Human Services, Centers for Disease Control and Prevention, 

National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 2021-116. https://doi.org/10.26616/NIOSHPUB2021116

DHHS (NIOSH) Publication No. 2021-116

DOI: https://doi.org/10.26616/NIOSHPUB2021116

May 2021