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                        EXHIBIT 10(m)

                     MATERIAL CONTRACTS

     SECOND COMMERCIAL PROMISSORY NOTE MODIFICATION AGREEMENT

     THIS SECOND COMMERCIAL PROMISSORY NOTE MODIFICATION
AGREEMENT is made this 30th day of November, 1996, by  and
between PHARMAKINETICS LABORATORIES, INC., a corporation
organized under the laws of the State of Maryland (the
"Borrower") and NATIONSBANK, N.A., formerly known as NATIONSBANK
OF MARYLAND, N.A.,  successor by merger to MARYLAND NATIONAL
BANK, a national banking association (the "Lender").

     WHEREAS, by that certain Commercial Promissory Note dated
May 13, 1993 (as amended, modified, restated, substituted,
extended and renewed at any time and from time to time, the
"Note") the Borrower became indebted to the Lender in an amount
not to exceed $500,000 (the "Revolving Credit Committed Amount")
under a revolving line of credit made by the Lender to the
Borrower pursuant to that certain Loan Agreement dated May 13,
1993 (as amended, modified, substituted, extended, and renewed
from time to time, the "Loan Agreement"); and

     WHEREAS, the Note matures on the date hereof and the
Borrower and the Lender wish to provide for the extension of the
Note's maturity as herein set forth.

     NOW, THEREFORE, THIS AGREEMENT WITNESSETH:

     That in consideration of the premises and other good and
valuable consideration, the receipt and sufficiency of which is
hereby acknowledged, the Lender and the Borrower covenant and
agree as follows:

     1. The Borrower acknowledges that the present principal
balance of the Note is due and owing, subject to the terms of
repayment hereinafter set forth, without defense, recoupment,
counterclaim or offset.

     2. The borrower and Lender agree that the maturity date in
the Note is hereby changed from November 30, 1996 to November 30,
1997.

     3. The terms, provisions and covenants of the Note are in 
all other respects hereby ratified and confirmed and remain in 
full force and effect.




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     4. It is expressly agreed that the indebtedness evidenced by
the Note has not extinguished or discharged hereby.  The Borrower
and the Lender agree that the execution of this Agreement is not
intended to and shall not cause or result in a novation with
regard to the Note.

     WITNESS the signatures and seals of the Borrower and the
Lender the day and year first above written.

WITNESS OR ATTEST:              PHARMAKINETICS LABORATORIES, INC.
/s/ Taryn L. Kunkel             By:/s/ James K. Leslie   (SEAL)
-------------------             -----------------------
                                James K. Leslie
                                President and
                                Chief Operating Officer

WITNESS:                        NATIONSBANK, N.A.
/s/ Taryn L. Kunkel             By:/s/ James W. Kirschner (SEAL)
-------------------             --------------------------
                                James W. Kirschner
                                Vice President

          GUARANTOR ACKNOWLEDGEMENT AND AGREEMENT
The undersigned respectively guaranteed to the Lender all of the
Obligations (as defined in the Loan Agreement), including without
limitation, the per annum rate of interest (as defined in the
annexed Second Commercial Promissory Note Modification Agreement)
and hereby covenants and agrees with the Lender that the
execution of the foregoing Second Commercial Promissory Note
Modification Agreement of even date herewith and the transactions
described therein and contemplated thereby do not and shall not
in any manner affect  its obligations and liabilities under its
guaranty dated May 13, 1993 (the "Guaranty"), and that the
Guaranty is hereby ratified and confirmed and remains in full
force and effect.

Dated effective as of this 30th day of November, 1996.

WITNESS:                  PKLB Limited Partnership
                          By:  PharmaKinetics Laboratories, Inc.
                               General Partner
/s/ Taryn L. Kunkel       By:/s/ James K. Leslie         (SEAL)
-------------------       -----------------------
                          James K. Leslie
                          President and 
                          Chief Operating Officer




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