Exhibit 10.7


 


LICENSE
AND SUBLlCENSE AGREEMENT


 


This
License and Sublicense Agreement (“Agreement”) is made effective as of May 22, 2017 (“Effective Date”)
by and between on the one hand On Target Therapeutics, LLC, 1S Wynnewood Road, Wellesley, MA 02481 (“On Target” or ‘‘Licensor’’),
and Biovitas Capital, 18 South Street, Mayfair, London, W1K 1DG, UK (“Licensee”). Licensor and Licensee
are each hereafter referred to individually as a “Party” and together as the “Parties.”


 


WHEREAS,
Licensee desires to obtain an exclusive license to patents owned or controlled by Licensor, a sublicense to certain patents licensed
from Tufts Medical Center (‘TMC”), along with any associated know-how, biologic materials, clinical data or other
technology relating to modified chemerin molecules and their use in order to research, develop and commercialize products and services;


 


WHEREAS,
the parties recognize that Licensee may assign this agreement to a third party provided all obligations under this Agreement are assumed
by such third party;


 


NOW,
THEREFORE, in consideration of the mutual covenants contained herein, and for other good and valuable consideration, the receipt and
adequacy of which are hereby acknowledged, the Parties hereby agree as follows:


 


1.
DEFINITIONS


 


Capitalized
terms used in this Agreement shall have the meanings specified below or elsewhere herein,


 


1.1.
“Affiliate” means any Person who directly or indirectly controls or is controlled by or is under common control with
another· Person, A Person shall only be considered an Affiliate during the duration of such control. For purposes of this definition,
“control” or “controlled” means ownership, directly or through one or more Affiliates, of fifty
percent (50%) or more of the shares of stock entitled to vote for the election of directors, in the case of a corporation, or fifty percent
(50%) or more of the equity interest, in the case of any other type of legal entity, or status as a general partner in any partnership,
or the contractual right to control the election of directors or direct the affairs of any Person,


 


1.2.
“Chemerin Product” means the chemerin molecules described and claimed In PCT/US2017014605, filed 1/23/2017 as included
in Licensed Patents.


 


1.3.
“Confidential Information” means with respect to a Party (the “Receiving Party”), all
information that is (i) disclosed by the other Party (the “Disclosing Party”) to the Receiving Party; and (ii)
would be reasonably understood from notices or legends, the nature of such information itself or the circumstances of such
information’s disclosure to be confidential by a reasonable person familiar with the applicable industry; provided, however,
that Confidential Information shall not include information that the Receiving Party can demonstrate by its records or other
suitable documentary evidence, (a) as of the date of disclosure is demonstrably known to the Receiving Party or its Affiliates other
than by virtue of a prior confidential disclosure to such Party or its Affiliates; (b) as of the date of disclosure is in, or
subsequently enters, the public domain, through no fault or omission of the Receiving Party; (c) ls obtained from a Third Party
having a lawful right to make such disclosure free from any obligation of confidentiality to the Disclosing Party; or (d) is
independently developed by or for the Receiving Party without reference to or reliance upon any Confidential Information of the
Disclosing Party.


 






    	 



     


    

 


1.4.
“Cover’ means with respect to Valid Claims in an issued patent, that, in the absence of a license, the use, sale,
or manufacture of the product in question would infringe such Valid Claim.


 


1.5.
“Field” means any and all uses including all therapeutic uses.


 


1.6,
“First Commercial Sale” means, on a country-by-country basis, the date of the first arm’s length transaction,
transfer or disposition for value by or on behalf of Licensee or any Affiliate or Sublicensee of Licensee to a Third ‘Party of
a Licensed Product after the granting of all regulatory approvals and marketing authorizations, First Commercial Sale excludes any sale
or other distribution in connection with seeking regulatory approval.


 


1.7,
“Licensor Indemnitees” means Licensor, its Affiliates and the directors, officers, employees and agents of LICENSOR
and its Affiliates.


 


1.8.
“Licensed Patents” means the patents and patent applications listed on Exhibit 1 hereto, and including all provisionals,
substitutions, continuations, continuations-in-part, divisionals, supplementary protection certificates, renewals, all letters patent
granted thereon, and all reissues, reexaminations, extensions, confirmations, revalidations, registrations, patents of addition thereof,
and foreign equivalents to any of the foregoing.


 


1.9.
“Licensed Product” means any product or service, the manufacture, use, sale, importation or performance of which would,
absent the license granted herein, infringe a Valid Claim of the Licensed Patents.


 


1.10,
“Licensee Indemnitees” means Licensee, its Affiliates, Sublicensees, and the directors, officers, employees and agents
of Licensee and its Affiliates.


 


1.11.
“Net Sales” means, for any period, the gross amount invoiced by Licensee and its Affiliates for the sale of Licensed
Products to third parties, less deduction for:


 


(a)
normal and customary trade, quantity and cash discounts and sates returns and allowances including (i) those granted on account of price
adjustments, billing errors, rejected goods, damaged goods, returns and rebates, (ii) administrative and other fees and reimbursements
and similar payments directly related to the sale or delivery of Licensed Products paid to wholesalers and other distributors, buying
groups, pharmacy benefit management organizations, health care insurance carriers and other institutions, (iii) allowances, rebates,
and fees directly related to the sale of delivery of License Products paid to distributors and (iv) chargebacks;


 


(b)
freight, postage, shipping and insurance costs to the extent that such items are included in the gross amount invoiced;


 




    	 



     


    

 


(c)
customs and excise duties and other duties related to the sales to the extent that such items are included in the gross amount invoiced;


 


(d)
rebates and similar payments made with respect to sales paid for or reimbursed by any governmental or regulatory authority such as, by
way of illustration, federal or state Medicaid, Medicare or similar state program or equivalent foreign governmental program;


 


(e)
sales and other taxes and duties directly related to the sale or delivery of Licensed Products (but not including taxes assessed against
the income derived from such sale) to the extent that such items are included in the gross amount invoiced;


 


(f)
distribution costs and expenses to the extent that such items are included in the gross amount invoiced;


 


(g)
any such invoiced amounts that are not collected by the parties or their Affiliates;


 


provided
that with respect to the deductions specified in subsections (a) through (g) above, an amount shall be deducted only once regardless
how many categories may apply to it.


 


Any
of the deductions listed above that involves a payment by Licensee or its Affiliates shall be taken as a deduction in the calendar quarter
in which the payment ls accrued, Deductions pursuant to section (g) above shall be taken in the calendar quarter in which such sales
are no longer recorded as a receivable. For purposes of determining Net Sales, the Licensed Products shall be deemed to be sold when
invoiced and a sale” shall not include transfers or dispositions for charitable, promotional, pre-clinical, clinical, regulatory
or governmental purposes.


 


For
the purposes of calculating Net Sales of Licensed Products, sales between or among Licensee or its Affiliates shall be excluded from
the computation of Net Sales, but sales by Licensee or its Affiliates to third parties shall be included in the computation of Net Sales,


 


In
the event that a Licensed Product is sold in any country in the form of a combination product containing one or more therapeutically
active ingredients in addition to the Licensed Product, with respect thereto, the parties shall negotiate in good faith to determine
what portion of the net sales of such combination product shall be treated as Net Sales under the Agreement, which determination shall
be based on the value added by the Licensed Product compared to the value added by sue other therapeutically effective ingredients, to
the invoice price of such combination product.


 


1.12,
“Person” means any individual, corporation, limited or general partnership, limited liability company, joint venture,
trust, unincorporated association, governmental body, authority, bureau or agency, or any other entity or body.


 




    	 



     


    

 


l.13.
“Royalty Term”means, with respect to each Licensed Product, the period of time beginning on the First Commercial Sale
of such Licensed Product in a country following the receipt of applicable regulatory approval with respect to such sale of such Licensed
Product in such country and continuing on a country-by-country and product-by-product basis until the later of (a) the expedition of
the last Valid Claim of the Licensed Patents which Covers the sale of such Licensed Product in such country or (b) the end of any market
exclusivity period granted by the relevant governmental authority in a country that prevents another party from marketing the same Licensed
Product.


 


1.14.
“Sublicensee” means any Third Party to whom Licensee grants a sublicense of some or all of the rights granted to Licensee
under this Agreement.


 


1.15.
“Sublicense Revenue” means all non-royalty cash payments received by Licensee or its Affiliates from Sublicensees
in consideration for and directly attributable to the grant by Licensee of a sublicense under the Licensed Patents, including any
upfront payments, license maintenance fees, milestone payments and the like. Sublicense Revenue will not include: (a) In the case
where Licensee collaborates on research and/or development with a Sublicensee, amounts paid by such Sublicensee as reimbursement for
research and development costs; (b) bona fide loans; (c) reimbursement for clinical trial costs and expenses; (d) equity investment
in Licensee to the extent such investments reflect the fair market value of such equity (any amounts paid in excess of fair market
value shall be deemed Sublicense Revenues); (e) amounts paid for supplies of Licensed Products or other tangible materials, or that
are otherwise paid in reimbursement of costs or expenditures, whether incurred before or after the date of the relevant sublicense
agreement; and (g) withholding taxes or other amounts actually withheld from the amounts received.


 


1.16.
“Territory” Worldwide.


 


1.17.
“Third Party” means any person or entity other than Licensee, Licensor and their respective. Affiliates.


 


1.18.
“Valid Claim” means a claim in an issued, unexpired patent within the Licensed Patents or a claim that has not been
pending more than five (5) years, in either case that (a) has not been finally cancelled, withdrawn, abandoned or rejected by any administrative
agency or other body of competent jurisdiction, (b) has not been revoked, held invalid, or declared unpatentable or unenforceable in
a decision of a court or other body of competent jurisdiction that is unappealable or unappealed within the time allowed for appeal,
(c) has not been rendered unenforceable through disclaimer or otherwise, and (d) is not lost through an interference proceeding.


 


2.
LICENSE GRANT


 


2.1.
License, Licensor hereby grants to Licensee a worldwide, exclusive license (even as to Licensor), including the right to grant
sublicenses, under the Licensed Patents, for Licensee and its Affiliates to research, develop, make, have made, use, offer for sale,
sell, have sold and import Licensed Products for any and all uses in the Field in the Territory, subject to the terms and conditions
of this Agreement. The foregoing Includes the right to employ Third Party
distributors to sell Licensed Products and Third Party contract manufacturers to make Licensed Products, neither of which shall be construed
as a sub-license.


 




    	 



     


    

 


2.2.
Sublicense to TMC Rights. Licensor hereby grants an exclusive sublicense to Licensee, including the right to grant further sublicenses,
under the License Agreement between On Target and TMC dated April 3, 2017, for the Chemerin Product a copy of which is attached hereto
as Exhibit 2, to make, have made, use, offer for sale, sell, have sold and/or import Licensed Products in the Field in the Territory,
Licensee acknowledges and agrees that the terms of the sublicense pursuant to this Agreement shall be subordinate to and consistent with
all the terms and conditions of the License Agreement between On Target and TMC.


 


3.
DEVELOPMENT AND COMMERCIAL1ZATION OF LICENSED PRODUCTS.


 


3.1.
Authority. Licensee shall have full control and authority over the research, development (including regulatory matters) and commercialization
of Licensed Products in the Field worldwide.


 


3.2.
Diligence. Licensee will, itself or through its Affiliates or Sublicensees, at all times exercise commercially reasonable efforts
to commercialize Licensed Products,


 


3.3.
Transfer of Data, Material and Know How. Licensor will transfer all necessary data, biologic material and documentation relevant
to the Chemerin Product to Licensee at no cost. Licensor will make key personnel reasonably available to Licensee for briefings, to answer
questions, and offer advice on pre-clinical data, science, and manufacturing.


 


4.
PAYMENTS


 


4.1.
Upfront Fee. Within five (5) days of the Effective Date, Licensee shall pay to Licensor the amount of $375,000 USD.


 


4.2.
Development Milestone Payments, Subject to the terms and conditions of this Agreement, Licensee shall pay the following development milestone
payments to Licensor, For the avoidance of doubt, the amounts below are inclusive of the milestone obligations to 1MC and Licensor is
responsible for payment of the relevant amounts to TMC:


 


	(a)	 	 	First  patient enrolled in a Phase I human clinical	 	$	300,000 USD	 
	(b)	 	 	First patient enrolled in a Phase II human clinical trial	 	$	600,000
USD	 
	(c)	 	 	First patient enrolled in a Phase III human clinical trial	 	$	1,500,000 USD	 
	(d)	 	 	First Commercial Sale of a Licensed Product	 	$	2,500,000
USD	 



 


4.3.
Sales Milestone Payments. Subject to the terms and conditions of this Agreement, Licensee shall pay the following Sales milestone
payments to Licensor. For the avoidance of doubt, the amounts below are inclusive of the milestone obligations to TMC an Licensor is
responsible for payment of the relevant amounts to TMC:


 




    	 



     


    

 


	(a)	 	 	First achievement of $50,000,000 annual Net Sales	 	$	2,000,000 USD	 
	(b)	 	 	First achievement of $100,000,000 annual Net Sales	 	$	4,000,000 USD	 
	(c)	 	 	First achievement of $250,000,000 annual Net Sales	 	$	6,000,000 USD	 
	(d)	 	 	First achievement of $500,000,000 annual Net Sales	 	$	10,000,000 USD	 
	(c)	 	 	First achievement of $1,000,000,000 annual Net Sales	 	$	15,000,000
USD	 



 


4.4.
Royalty Revenue. Licensee will pay to Licensor a royalty of three percent (3.0%) on Net Sales of any Licensed Product.


 


4.5.
Sublicense Revenue. Licensee will pay to Licensor fifteen percent (150%) on any non-royalty Sublicense Revenue received in connection
with any Licensed Product.


 


4.6.
Payment Terms,


 


4.6.1.
Payment of Received Revenue, Licensee shall make any payments owed to Licensor hereunder in arrears, within ninety (90) days from
the end of each quarter m which such payment accrues, Each payment shall be accompanied by a report for each country in which sales of
Licensed Products occurred in the calendar quarter covered by such statement, specifying: the gross sales (if available) and sales in
each country’s currency; the applicable revenue sharing amount under this Agreement; the amount payable in each country’s
currency, including an accounting of deductions taken in accordance with Licensee’s accounting practices; the applicable exchange
rate to convert from each country’s currency to United States Dollars; and the amounts payable in United States Dollars,


 


4.6.2.
Accounting. All payments hereunder shall be made in in United States dollars, Conversion of foreign currency to United States
dollars shall be made in the same manner as Licensee converts all of its other revenues, provided that (a) such manner 18 consistent
with United States generally accepted accounting principles, and (b) the exchange rates employed are those quoted by a reputable source,
such as a recognized money center bank such as JP Morgan, Bank of America or an equivalent,.


 


4.6.3.
Tax Withholding; Restrictions on Payment. All payments hereunder shall be made free and clear of any taxes, duties, levies, fees
or charges, except for withholding taxes and interest and penalties thereon (to the extent applicable). Licensee shall make any applicable
withholding payments due on behalf of Licensor and shall provide Licensor upon request with such written documentation regarding any
such payment as available to Licensee relating to an application by Licensor for a foreign tax credit for such payment with the United
States Internal Revenue Service. Licensor shall provide all information necessary to determine if withholding taxes are applicable,


 


4.7.
Records Retention by Licensee; Review.


 


4.7.1.
Royalty Records. Commencing as of the date of First Commercial Sale of the first Licensed Product hereunder, Licensee and its
Affiliates and Sublicenses shall keep for at least three (3) years from the end of the calendar year to which they pertain complete and
accurate records of sales by Licensee or its Affiliates and Sublicensees, as the case may be,
of each Licensed Product, in sufficient detail to allow the accuracy of the payments hereunder to be confirmed, ‘


 







    	 



     


    

 





4.7.2. Review,
Subject to the other terms of this Section 4.7, at the request of Licensor, which shall not be made more frequently than once per
calendar year during the Term, and upon at least thirty (30) days’ prior written notice from Licensor, and at the expense of
Licensor (except as otherwise provided herein), Licensee shall permit an independent certified public accountant selected by
Licensor and reasonably acceptable to Licensee to inspect (during Licensee’s regular business hours) the relevant records
required to be maintained by Licensee under Section 4.7, In every case the accountant must have previously entered into a
confidentiality agreement with both Parties substantially similar to the provisions of Article 5 and limiting the disclosure and use
of such information by such accountant to authorized representatives of the Parties and the purpose of verifying amounts payable to
Licensor hereunder. Results of any such review shall be binding on both Parties absent manifest error. If any review reveals a
deficiency in the calculation and/or payment of amounts owed by Licensee, then (a) Licensee shall pay Licensor the amount remaining
to be paid, and (b) if such underpayment is by ten percent (10%) or more for any twelve (12) month consecutive period, then
Licensee shall reimburse Licensor for its reasonable out of-pocket costs and expenses incurred in performing the review,


 


5.
TREATMENT OF CONFIDENTIAL INFORMATION


 


5.1.
Confidential Obligations. Licensor and Licensee each recognize that the other Party’s Confidential Information constitutes
highly valuable and proprietary confidential information. Licensor and Licensee each agree that during the Term and for five (5) years
thereafter, it will keep confidential, and will cause its employees, consultants (including academic collaborators, CROs and manufacturers),
professional advisors, Affiliates and, in the case of Licensee, Sublicensees to keep confidential, all Confidential Information of the
other Party, Neither Licensor nor Licensee nor any of their respective employees, consultants, Affiliates or, in the case of Licensee,
Sublicensees, shall use any Confidential Information the other Party for any purpose whatsoever other than exercising any rights granted
to t hereunder or as expressly permitted in this Article 5. Licensee may disclose Licensor’s Confidential Information to
the extent such disclosure is reasonably necessary to file d prosecute patent applications and/or maintain patents which are filed or
prosecuted in accordance with the provisions of this Agreement, or to obtain any authorization to conduct clinical studies or any regulatory
approval for Licensed Products. Each Party may disclose the other Party’s Confidential Information as reasonably necessary to file,
conduct or defend litigation in accordance with the provisions of this Agreement or comply with applicable laws, regulations or court
orders; provided, however, that if a Party is required to make any such disclosure of the other Party’s Confidential Information
in collection with any of the foregoing, it will give reasonable advance notice to the other Party of such disclosure requirement and
will use reasonable efforts to assist such other Party in efforts to secure confidential treatment of such information required to be
disclosed.


 


5.2. Limited
Disclosure and Use. Each Party may disclose the other Party’s Confidential Information to any of its officers, employees,
consultants, agents or Affiliates, or in the case of Licensee, Sublicensees, if and only to the extent necessary to carry out its
rights and
responsibilities under this Agreement. Such disclosures shall be limited to the maximum extent possible consistent with such rights and
responsibilities and shall only be made to the extent any such persons receiving the other Party’s Confidential Information are
bound by written confidentiality obligations to maintain the confidentiality thereof and not to use such Confidential Information except
as expressly permitted by this Agreement. LICENSOR and Licensee each agree not to disclose or transfer the other Party’s Confidential
Information to any Third Parties under any circumstance without the prior written approval from the other Party, except ns otherwise
required by law, and except ns otherwise expressly permitted under this Article 5 or elsewhere in this Agreement. Each Party shall take
such action, and shall cause its Affiliates, and in the case of Licensee, Sublicensees, to take such action, to preserve the confidentiality
of each other’s Confidential Information as it would customarily take to preserve the confidentiality of its own Confidential Information,
using, in all such circumstances, not less than reasonable care. Each Party, upon the request of the other Party, will return all the
Confidential Information disclosed or transferred to it by the other party pursuant to this Agreement, including all copies and extracts
of documents and all manifestations in whatever form, in such Party’s possession within sixty (60) days of such request or, if
earlier, the termination or expiration of this Agreement; provided however, that a Party may retain (a) any Confidential Information
of the other Party relating to any license that is still in force hereunder or which expressly survives such termination, and (b) one
(1) copy of all other Confidential Information in inactive archives solely for the purpose of establishing the contents thereof.


 







    	 



     


    

 





5.3.
Terms of Agreement. The terms of this Agreement constitute each Party’s Confidential Information; provided, however, that
either Party may disclose the terms of this Agreement (a) to the extent required by law or by the requirements of any nationally recognized
securities exchange, quotation system or over-the-counter market on which such Party has its securities listed or traded, or (b) in confidence
to its attorneys, accountants and other fiduciaries, and (c) to any acquirers, potential acquirers, investors, prospective investors,
lenders and other potential financing sources who are obligated to keep such information confidential.


 


5.4.
Press Release. The Parties shall diligently work together to draft a mutually agreeable press release announcing the execution
of this Agreement such announcement to be made no later than 07:00 on the day following the Effective Date, and shall publish such press
release in a mutually agreeable manner.


 


6.
FILING, PROSECUTION AND MAINTENANCE OF PATENT RIGHTS


 


6.1.
Prosecution Control. For purposes of this Article 6, the right to control prosecution of a Patent Right shall include the right
to control preparing, filing, and prosecuting patent applications therefor, and obtaining and maintaining any resulting patents, including
the conduct of interferences, the defense of oppositions and other similar proceedings with respect to a patent.





 


6.2. Patent
Prosecution. Licensee shall, at its expense, assume control of the prosecution of the Licensed Patents, subject to the
provisions of this Article 6. If Licensee decides not to prosecute or maintain any Patent Right within the Licensed Patents, then Licensee
shall provide Licensor with written notice of such decision prior to the deadline for taking any action for such Patent Right or the
date on which the abandonment of any such Patent Right would become effective, whichever is earlier, If Licensee does not wish to continue
prosecution of a case or decides not to file in a particular country, then Licensor may do so at Licensor’s own cost. Licensee
shall pay the December 2014 costs of National Phase entry for Licensed Patent.


 




    	 



     


    

 





6.3.
Right of Review and Comment. Licensee shall consult with Licensor regarding the prosecution of the Licensed Patents by using commercially
reasonable efforts to provide Licensor a Reasonable Opportunity to review and comment on all proposed submissions to any patent office
before submission, where “Reasonable Opportunity” means that Licensee shall provide Licensor or patent counsel true
copies of all documents relating to filing, registration, prosecution, and maintenance of patent applications and patents within the
Licensed Patents as soon as reasonably practical after Licensee has received such documents and materials. Licensee shall consider in
good faith Licensor’s comments concerning such documents and materials that it timely receives.


 


7.
PATENT ENFORCEMENT


 


7.1.
Notice of Infringement. If during the Term, either Party learns of any actual, alleged or threatened infringement by a Third Party
of any Licensed Patents, such Party shall promptly notify the other Party and shall provide the other Party with available evidence of
such infringement. ·


 


7.2.
Infringement of Patent Rights. Licensee shall have the first right (but not the obligation), at its own expense and with legal
counsel of its own choice, to bring suit (or take other appropriate legal action) against any actual, alleged or threatened infringement
of the Licensed Patents in the Field by any product or service that competes with a Licensed Product, as reasonably determined by Licensee.
Licensor shall take all actions necessary to assist Licensee in any suit, including joining in such suit as a party if legally required,
at Licensee’s expense. Licensor shall have the right, at its own expense, to be represented in any such action by counsel of Licensor’s
own choice; provided, however, that the foregoing shall not affect the right of Licensee to control the suit as described in this Section,
In the event that the Licensee does not bring suit, Licensor shall have the right to bring suit, provided that there is no commercially
reasonable reason that Licensee did not bring suit.


 


8.
REPRESENTATIONS AND WARRANTIES


 


8.1.
Licensor Representations. Licensor represents, warrants and covenants to Licensee that:


 


8.1.1.
the execution and delivery of this Agreement and the performance of the transactions contemplated hereby have been duly authorized by
all appropriate Licensor corporate action;


 


8.1.2.
this Agreement is a legal and valid obligation binding upon Licensor and enforceable in accordance with its terms, and the execution,
delivery and performance of this
Agreement by the Parties does not conflict with any agreement, instrument or understanding to which Licensor is a party or by which it
is bound;


 




    	 



     


    

 





8.1.3.
Licensor has the full right and legal capacity to grant the rights granted to Licensee hereunder; .


 


8.
l.4. The Licensed Patents have been properly filed and prosecuted as of the Effective Date;


 


8.1.5.
Licensor is the sole owner or exclusive licensee of the Licensed Patents;


 


8.1.6.
As of the Effective Date, Licensor has not licensed or transferred to any Person, including Licensor Affiliates, any rights under the
Licensed Patents; and


 


8.1.7.
Licensor is not aware of any Third Party patent, patent application other intellectual property right that would be infringed (i) by
practicing any process or method or by making, using or selling any composition which is claimed or disclosed in, or which constitutes,
Licensed Patents, or (ii) by making, using, offering for sale, selling or importing Licensed Product.


 


8.2.
Licensee Representations. Licensee represents .and warrants to Licensor that:


 


8.2.
l. the execution and delivery of this Agreement and the performance of the transactions contemplated hereby have been duly authorized
by all appropriate Licensee corporate action; and


 


8.2.2.
This Agreement is a legal and valid obligation binding upon Licensee and enforceable in accordance with its terms, and the execution,
delivery and performance of this Agreement by the Parties does not conflict with any agreement, instrument or understanding to which
Licensee is a party or by which it is bound.


 


8,3. No
Warranties. Except as expressly set forth in this Agreement, NEITHER PARTY MAKES ANY REPRESENTATION OR EXTENDS ANY WARRANTIES OF
ANY KIND, EITHER EXPRESS OR IMPLIED, THERE ARE NO EXPRESS OR IMPLIED WARRANTIES OF MERCHANTABILITY OR FITNESS FOR A
PARTICULAR PURPOSE, OR OF NON-INFRINGEMENT OF ANY PATENT, COPYRIGHT, TRADEMARK, OR OTHER RIGHTS OF THIRD PARTIES, OR AS TO THE
SUCCESS OR LIKELIHOOD OF SUCCESS OF THE RESEARCH, DEVELOPMENT OR COMMERCIALIZATION OF LICENSED PRODUCTS UNDER THIS AGREEMENT, OR ANY
OTHER EXPRESS OR IMPLIED WARRANTIES.


 


9.
INDEMNIFICATION


 


9.1.
Indemnification by Licensee, Licensee shall indemnify, defend and hold harmless the Licensor Indemnitees from and against any
and all losses, damages, fees, expenses, settlement amounts and costs (including reasonable attorneys’ fees and witness
fees) (collectively, “Losses”) relating to or in connection with a Third Party claim arising after the Effective Date out
of (a) any breach by Licensee of its representations, warranties or covenants made
under this Agreement, or (b) any actual or alleged death, personal bodily injury or damage to real or tangible personal property claimed
to result, directly or indirectly, fro1n the possession, use or consumption of; or treatment with, the Licensed Product made or sold
by or on behalf of Licensee or its Affiliates or Sublicensees, including any product liability claims; provided, however, that the foregoing
indemnity shall not apply to the extent that any such Losses (i) are attributable to the negligence or willful misconduct of the Licensor
Indemnitees, or
(ii) are subject to an obligation by Licensor to indemnify the Licensee Indemnitees under Section 9.2.






 




    	 



     


    

 





9.2.
Indemnification by Licensor, Licensor shall indemnify, defend and hold harmless the Licensee Indemnitees from and against any
and all Losses relating to or in connection with a Third Party claim arising after the Effective Date out of (a) any breach by Licensor
of its representations, wanm1ties or covenants made under this Agreement, or (b) any negligent act or omission or willful misconduct
of Licensor or its Affiliates or its or their sublicensees, or any of their employees, contractors or agents, ln performing Licensor’s
obligations or exercising Licensor’s rights under this Agreement; provided, however, that the foregoing indemnity shall not apply
to the extent that any such Losses are attributable to (i) the negligence or willful misconduct of the Licensee Indemnitees, or (ii)
are otherwise subject to an obligation by Licensee to indemnify the Licensor Indemnitees under Section 9.1.


 


10.
TERM AND TERMINATlON


 


10.1,
Term; Expiration. Unless earlier terminated in accordance with this Article, the term of this Agreement (the “Term”)
shall commence as of the Effective Date and remain in force until the Royalty Term has expired with respect to all Licensed Products
in all countries,


 


I0.2..
Termination for Breach. Subject to the other terms of this Agreement, this Agreement and the rights granted herein may be terminated
by either Party for the material breach by the other Party of all material obligation or condition hereof, provided that the breaching
Party has not cured such breach within forty-five (45) days after the date of written notice to the breaching Party in the case of a
payment breach and one hundred twenty (120) days after the date of written notice to the breaching Party in the case of any other breach,
which notice shall describe such breach in reasonable detail and shall state the non-breaching Party’s intention to terminate this
Agreement pursuant to this Section or in the case of Licensee, its intention to either terminate this Agreement or elect its alterative
remedy pursuant to Section 10.8.


 


10.3.
Voluntary Termination, Licensee may terminate this Agreement at any time upon ninety (90) days’ notice to Licensor.


 


10.4. Effects
of Expiration or Termination. Upon any termination of this Agreement, (i) as of the effective date of such termination
all licenses granted by Licensor to Licensee under this Agreement hereunder shall terminate automatically; provided, however, that
Licensee and its Affiliates and Sublicensees may sell Licensed Products in their inventory as of the effective date of such
termination, subject to the payment of royalties under Section 4, and (ii) each Party shall return all Confidential Information of
the other Party. For the avoidance
of doubt, in the event of a voluntary termination or termination due to uncured breach by Licensee, then all Licensed Patents and any
improvements thereto necessary to make use and sell a Licensed Product, as well as all clinical trial data, biologic materials and other
information necessary and desirable to make, use and sell Licensed Product shall revert to Licensor.


 




    	 



     


    

 


10.5.
Survival of Sublicenses. Notwithstanding anything to the contrary, no termination of this Agreement shall be construed as a termination
of any sublicense of any Sublicensee, and thereafter each such Sublicensee shall be considered a direct licensee of Licensor, provided
that (i) Licensee represents and warrants to Licensor that, to Licensee’s actual knowledge, as of the effective date of such termination,
such Sublicensee is then in full compliance with all terms and conditions of its sublicense, (ii) such Sublicensee agrees in writing
to assume all applicable obligations of Licensee under this Agreement.


 


10,6,
Remedies. Except as otherwise expressly set forth in this Agreement, the termination provisions of this Article 11 are in addition
to any other relief and remedies available to either Party at law.


 


10.7,
Surviving Provisions. Notwithstanding any provision herein to the contrary, the rights and obligations of the Parties set forth
in Articles and Sections 1 (Definitions), 4.7 (Records Retention by Licensee; Review), 5 (Treatment of Confidential Information), 8 (Representations
and Warranties), 9 (Indemnification), 10.4 (Effects of Expiration or Termination), 10.5 (Survival of Sublicensees), 10.6 (Remedies),
7 (Surviving Provisions), and 11 (Miscellaneous) as well as any rights or obligations otherwise accrued hereunder (including any accrued
payment obligations), shall survive the expiration or termination of the Term. Without limiting the generality of the foregoing, Licensee
shall have no obligation to make any milestone or payment to Licensor that has not accrued prior to the effective date of any termination
of this Agreement.


 


10.8.
Remedy in Lieu of Termination. If Licensor materially breaches or defaults with respect to any material obligation or condition of
this Agreement and fails to cure such breach or default within one hundred twenty (120) days after receipt of written notice from Licensee
that describes such breach in reasonable detail, Licensee may reduce each of its payment obligations under this Agreement by fifty percent
(50%), which reduction shall be effective with respect to any payment obligations that come due on or after the first day following such
one hundred twenty (120) day cure period. The foregoing shall be in lieu of any right of termination of this Agreement, if any, for such
material breach or default, but in any event will be without prejudice to any other right or remedy that may be available to Licensee
under this Agreement or at law or in equity.


 


11.
MISCELLANEOUS


 


11.1.
Notices. All notices, requests and other communications hereunder shall be in writing, shall be addressed to the receiving Party’s
address set forth below or to such other address as a Party may designate by notice hereunder, and shall be either (i) delivered by hand,
(ii) made by email (to be followed with postal confirmation), (iii) sent by private courier service providing evidence of receipt, or
(iv) sent by registered or certified mail, return receipt requested, postage prepaid. The addresses and other contact information for
the Parties are as follows:


 




    	 



     


    

 





	 	If
                                            to LICENSOR:

     
	On
                                            Target Therapeutics.

    1
    Harrington Lane,

    Weston,
    MA02493

    Phone:+17812231161

     

	 	If
    to Licensee:	Biovitas
                                            Capital

    18
    South Street, Mayfair, London W1K 1DG, UK Phone: 

+44 (0) 20 7493 2853



 


All
notices, requests and other communications hereunder shall be deemed to have been given either (i) if by hand, at the time of the delivery
thereof to the receiving Party at the address of such Party set forth above, (ii) if made by telecopy or facsimile transmission, at the
time that receipt thereof has been acknowledged by the recipient, (iii) if sent by private courier, on the day such notice is delivered
to the recipient, or (iv) if sent by registered or certified mail, on the seventh (7th) business day following the day such mailing is
made.


 


11.2.
Language. The Parties hereto have requested that this Agreement and any related documents be drafted in English, which shall be
controlling for all purposes. Any translation of this Agreement or any part hereof into a language other than English ls for convenience
only, and only the original English language version of this Agreement, as it may be amended from time to time as permitted herein, shall
have legal effect.


 


11.3.
Governing Law. This Agreement will be construed, interpreted and applied in accordance with the laws of Delaware (excluding any
law controlling conflicts of law). The UN Convention for the International Sale of Goods shall not apply to this Agreement.


 


11.4.
Venue. Any dispute, controversy or claim initiated by either Party arising out of, resulting from or relating to this Agreement,
or the performance by either Party of its obligations under this Agreement, whether before or after termination of this Agreement, shall
be subject to the sole jurisdiction of, and venue in, the courts of competent jurisdiction located within Delaware. Licensee and Licensor
each irrevocably consent to the jurisdiction of such courts, irrevocably waive any objection based on inconvenience of forum, and agree
that process may be served in the manner provided herein for giving notices or otherwise as allowed by the law of Delaware. Notwithstanding
the foregoing, either Party shall have the right, without waiving any right or remedy available to such Party under this Agreement or
otherwise, to seek and obtain from any court of competent jurisdiction any Interim or provisional relief that is necessary or desirable
to protect the rights or property of such Party.


 


11.5.
Entire Agreement; Amendment. This Agreement comprises the entire Agreement between the Parties with respect to the subject matter
hereof and thereof and supersede all prior representations, understandings and agreements between the Parties with respect to the subject
matter hereof. No modification shall be effective unless in writing with specific references: to this Agreement and signed
by the Parties.


 




    	 



     


    

 


11.6.
Assignment. Licensee may, without the written consent of Licensor, assign this Agreement, in whole or in part, and its rights and delegate
its obligations hereunder to its Affiliates, for any reason, Including without limitation in the event of its merger, consolidation,
change in control or similar transaction, Any permitted assignee shall assume all obligations of its assignor under this Agreement. The
terms and conditions of this Agreement shall be binding upon and Inure to the be11efit of the permitted successors and assigns of the
Parties,


 


11.7.
Force Majeure. Neither Party shall be liable for failure of or delay in performing obligations set forth in this Agreement, and
neither shall be deemed in breach of its obligations, if such failure or delay is due to natural disasters or any causes beyond the reasonable
control of such Party. In event of such force majeure, the Party affected thereby shall use reasonable efforts to cure or overcome the
same and resume performance of its obligations hereunder.


 


11.8. Construction. The
Parties hereto acknowledge and agree that; (i) each Party and its counsel reviewed and negotiated the terms and provisions of this
Agreement and have contributed to its revision; (ii) the rule of construction to the effect that any ambiguities are resolved
against the drafting Party shall not be employed in the interpretation of this Agreement; and (iii) the terms and provisions of this
Agreement shall be construed fairly as to all Parties hereto and not in favor of or against any Party, regardless of which Party was
generally responsible for the preparation of this Agreement. In this Agreement: (a) the word “including” shall be deemed
to be followed by the phrase “without limitation” or like expression; (b) the singular shall include the plural and vice
versa; (c) masculine, feminine and neuter pronouns and expressions shall be interchangeable, (d) all references to
“days” means “calendar days” unless expressly stated to be “business days,” and (e) all
references to dollars or $ are to United States dollars, whether or not so expressly stated.


 


l
l.9. Severability. If any provision(s) of this Agreement arc or become invalid, are ruled legal by any court of competent jurisdiction
or are deemed unenforceable under then current applicable law from time to time in effect during the Term hereof, it is the intention
of the Parties that such provision(s) be deemed to be severed from this Agreement and the remainder of this Agreement shall not be affected
thereby. The Parties hereto agree to renegotiate any such severed provision in good faith in order to provide a reasonably acceptable,
valid alternative to the severed provision, it being the intent of the Parties that the basic purposes of this Agreement are to be effectuated.


 


11.10.
Status. Further Assurances. Each Party agrees to execute, acknowledge and deliver such further instructions, and to do all such
other acts, as may be necessary or appropriate in order to carry out the purposes and intent of this Agreement.


 


11.11,
Counterparts. This Agreement may be executed simultaneously in one or more counterparts, each of which shall be deemed an original,
but all of which together shall constitute one and the same Instrument.


 


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EXHIBIT 1


 





 






    	 



     


    

 


EXHIBIT 2