# Patent

## Title
Crystallization of (20R) and (20S) analogs of 2-methylene-19-nor-24-dimethyl-1α,25-dihydroxyvitamin D3

## Abstract

Disclosed are methods of purifying (20R) and (20S) analogs of 2-methylene-19-nor-22-dimethyl-1α,25-dihydroxyvitamin D3 to obtain the (20R) and (20S) analogs in crystalline form. The method includes the steps of preparing a solvent of either diethyl ether or a mixture of 2-propanol and hexane, dissolving a product containing the (20R) and (20S) analog to be purified in the solvent, cooling the solvent and dissolved product below ambient temperature for a sufficient amount of time to form a precipitate of crystals, and recovering the crystals.

## Background
CROSS-REFERENCE TO RELATED PATENT APPLICATIONS
The present application claims the benefit under 35 U.S.C. §119(e) to U.S. Provisional Patent Application No. 61/652,965, filed on May 30, 2012, the content of which is incorporated herein by reference in its entirety.


STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT
This invention was made with government support under DK047814 awarded by the National Institutes of Health. The government has certain rights in the invention.


BACKGROUND
The field of the present invention relates to purification of organic compounds, and more particularly to the purification of (20S) and (20R) analogs of 2-Methylene-19-nor-22-dimethyl-1α,25-dihydroxyvitamin D3 (referred to herein as “MET-1” and “MET-2” respectively) by preparing them in crystalline form.
Purification of organic compounds, especially those designated for pharmaceutical use, is of considerable importance for chemists synthesizing such compounds. Preparation of the compound usually requires many synthetic steps and, therefore, the final product can be contaminated not only with side-products derived from the last synthetic step of the procedure but also with compounds that were formed in previous steps. Even chromatographic purification, which is a very efficient but relatively time-consuming process, does not usually provide compounds which are sufficiently pure to be used as drugs.
Depending on the method used to synthesize 1α-hydroxyvitamin D compounds, different minor undesirable compounds can accompany the final product. Thus, for example, if direct C-1 hydroxylation of the 5,6-trans geometric isomer of vitamin D is performed, followed by SeO2/NMO oxidation and photochemical irradiation, (see Andrews et al., J. Org. Chem. 51, 1635 (1986); Calverley et al., Tetrahedron 43, 4609 (1987); Choudry et al., J. Org. Chem. 58, 1496 (1993)), the final 1α-hydroxyvitamin D product can be contaminated with 1β-hydroxy—as well as 5,6-trans isomers. If the method consists of C-1 allylic oxidation of the 4-phenyl-1,2,4-triazoline-3,5-dione adduct of the pre-vitamin D compound, followed by cycloreversion of the modified adduct under basic conditions, (see Nevinckx et al., Tetrahedron 47, 9419 (1991); Vanmaele et al., Tetrahedron 41, 141 (1985) and 40, 1179 (1994); Vanmaele et al., Tetrahedron Lett. 23. 995 (1982)), one can expect that the desired 1α-hydroxyvitamin can be contaminated with the pre-vitamin 5(10), 6,8-triene and 1β-hydroxy isomer. One of the most useful C-1 hydroxylation methods, of very broad scope and numerous applications, is the experimentally simple procedure elaborated by Paaren et al., J. Org. Chem. 45, 3253 (1980) and Proc. Natl. Acad. Sci. U.S.A. 75, 2080 (1978). This method consists of allylic oxidation of 3,5-cyclovitamin D derivatives, readily obtained from the buffered solvolysis of vitamin D tosylates, with SeO2/t-BuOOH and subsequent acid-catalyzed cycloreversion to the desired 1α-hydroxy compounds. Taking into account this synthetic path, it is reasonable to assume that the final product can be contaminated with 1α-hydroxy epimer, 5,6-trans isomer and the previtamin D form. 1α-hydroxyvitamin D4 is another undesirable contaminant found in 1α-hydroxyvitamin D compounds synthesized from vitamin D2 or from ergosterol. 1α-hydroxyvitamin D4 results from C-1 oxidation of vitamin D4, which in turn is derived from contamination of the commercial ergosterol material. Typically, the final product may contain up to about 1.5% by weight 1α-hydroxyvitamin D4. Thus, a purification technique that would eliminate or substantially reduce the amount of 1α-hydroxyvitamin D4 in the final product to less than about 0.1-0.2% would be highly desirable.
The vitamin D conjugated triene system is not only heat- and light-sensitive but it is also prone to oxidation, leading to the complex mixture of very polar compounds. Oxidation usually happens when a vitamin D compound has been stored for a prolonged time. Other types of processes that can lead to a partial decomposition of vitamin D compounds consist of some water-elimination reactions. The driving force for these reactions is the allylic (1α-) and homoallylic (3β-) position of the hydroxy groups. The presence of such above-mentioned oxidation and elimination products can be easily detected by thin-layer chromatography.
Usually, all 1α-hydroxylatation procedures require at least one chromatographic purification. However, even chromatographically purified 1α-hydroxyvitamin D compounds, although showing consistent spectroscopic data that suggests homogeneity, do not meet the purity criteria required for therapeutic agents that can be orally, parenterally or transdermally administered. Therefore, it is evident that a suitable method of purification of the 1α-hydroxylated vitamin D compounds MET-1 and MET-2 is required.
SUMMARY
Disclosed are methods of purifying MET-1 and MET-2 by means of crystallization to obtain MET-1 and MET-2 in crystalline form. The solvent plays an important role in the crystallization process, and is typically an individual liquid substance or a suitable mixture of different liquids. For crystallizing MET-1 and MET-2, the most appropriate solvent and/or solvent system is characterized by the following factors:

    
    
        (1) low toxicity;
        (2) low boiling point;
        (3) significant dependence of solubility properties with regard to temperature (condition necessary for providing satisfactory crystallization yield); and
        (4) relatively low cost.
    
    


Interestingly, hexane, so frequently used for crystallization purposes, was found less suitable as the sole solvent for crystallization of MET-1 and MET-2. However, it was found that diethyl ether (Et2O) was most useful for the crystallization of MET-1, and a mixture of 2-propanol and hexane, was most useful for the crystallization of MET-2. In particular, it was determined that a mixture of about 10% to about 20% 2-propanol with about 90% to about 80% hexane by volume, (preferably 15% 2-propanol with about 85% hexane by volume) performed well. The diethyl ether solvent and the 2-propanol/hexane solvent mixture both were easy to remove by evaporation or other well-known methods. In all cases the crystallization process occurred easily and efficiently. The precipitated crystals were sufficiently large to assure their recovery by filtration or other means, and thus were suitable for x-ray analysis.
Accordingly, disclosed is a compound having the formula:




in crystalline form, where the wavy line at carbon 20 indicates the methyl group attached to carbon 20 may be in its R or S orientation. More specifically, disclosed are (20S)-2-methylene-19-nor-22-dimethyl-1α,25-dihydroxyvitamin D3 in crystalline form (otherwise referred to as “MET-1”), and (20R)-2-methylene-19-nor-22-dimethyl-1α,25-dihydroxyvitamin D3 in crystalline form, (otherwise referred to as “MET-2”).




BRIEF DESCRIPTION OF THE DRAWINGS
FIG. 1 is an illustration of the three dimensional molecular structure for MET-1 as defined by the atomic positional parameters discovered and set forth herein.
FIG. 2 is an illustration of the three dimensional molecular structure for MET-2 as defined by the atomic positional parameters discovered and set forth herein.



DETAILED DESCRIPTION
Disclosed herein is (20S)-2-methylene-19-nor-22-dimethyl-1α,25-dihydroxyvitamin D3 (MET-1) in crystalline form, which is a pharmacologically important compound characterized by the formula I shown below:




Also disclosed herein is (20R)-2-methylene-19-nor-22-dimethyl-1α,25-dihydroxyvitamin D3 (MET-2) in crystalline form, which also is a pharmacologically important compound characterized by the formula II shown below:




Also disclosed herein are methods of purifying MET-1 and MET-2. The purification technique typically involves obtaining the MET-1 and MET-2 products in crystalline form by utilizing a crystallization procedure wherein the material to be purified is dissolved using as the solvent either diethyl ether (Et2O) as the sole solvent to obtain MET-1, or a mixture comprised of 2-propanol and hexane to obtain MET-2. In particular, it was determined that a mixture of about 10% to about 20% 2-propanol (v/v) with about 90% to about 80% hexane (v/v) performed well. Preferably the mixture comprises about 15% 2-propanol (v/v) and about 85% hexane (v/v). Thereafter, the solvent can be removed by evaporation, with or without vacuum, or other means as is well-known in the art. Alternatively, the resultant crystals may be filtered from the mother liquor. The technique can be used to purify a wide range of final products containing MET-1 and MET-2 obtained from any known synthesis thereof, and in varying concentrations, which may range from microgram amounts to kilogram amounts. As is well known to those skilled in this art, the amount of solvent utilized should be modulated according to the amount of MET-1 and MET-2 to be purified.
EXAMPLES
The following examples are illustrative and should not be interpreted as limiting the claimed subject matter.
The usefulness and advantages of the present crystallization procedure is shown in the following specific Examples. After crystallization, the precipitated material was observed under a microscope to confirm its crystalline form. Yields of crystals were relatively high and the obtained crystals showed a relatively sharp melting point of 99° C. (MET-1) and 154° C. (MET-2).
The described crystallization process of the synthetic MET-1 and MET-2 products represents a valuable purification method, which can remove most side products derived from the synthetic path. Such impurity may result from contamination of starting raw materials. The crystallization process occurred easily and efficiently. The precipitated crystals were sufficiently large to assure their recovery by filtration, or other means, and thus were suitable for x-ray analysis.
Example 1
Crystallization of (20S)-2-methylene-19-nor-22-dimethyl-1α,25 dihydroxyvitamin D3 (MET-1)
Crystallization from Diethyl Ether.
(20 S2-methylene-19-nor-22-dimethyl-1α,25-dihydroxyvitamin D3 (MET-1) (14.3 mg), was dissolved in boiling diethyl ether (3 mL) and left at room temperature for about 1 hour, then it was kept in a refrigerator for about 48 hours. The precipitated crystals were filtered off, washed with a small volume of a cold (0° C.) diethyl ether, and dried to give crystalline material.
Experimental.
A colorless prism-shaped crystal of dimensions 0.25×0.34×0.55 mm was selected for structural analysis. Intensity data were collected using a Bruker AXS Platinum 135 CCD detector controlled with the PROTEUM software suite (Bruker AXS Inc., Madison, Wis.). The x-ray source was CuK radiation (1.54178 Å) from a Rigaku RU200 x-ray generator equipped with Montel optics, operated at 50 kV and 90 mA. The x-ray data were processed with SAINT version 7.06A (Broker AXS Inc.) and internally scaled with SADABS version 2005/1 (Broker AXS Inc.). The sample was mounted on a glass fiber using vacuum grease and cooled to 100 K. The intensity data were measured as a series of phi and omega oscillation frames each of 1° for 10-25 sec/frame. The detector was operated in 1024×1024 mode and was positioned 4.5 cm from the sample. Cell parameters were determined from a non-linear least squares fit of 3265 peaks in the range of 4.0<theta<55°. The data were merged to form a set of 4624 independent data with R(int)=0.0287.
The monoclinic space group P2(1) was determined by systematic absences and statistical tests and verified by subsequent refinement. The structure was solved by direct methods and refined by full-matrix least-squares methods on F2, (a) G. M. Sheldrick (1994), SHELXTL Version 5 Reference Manual, Broker AXS Inc.; (b) International Tables for Crystallography, Vol. C, Kluwer: Boston (1995). Hydrogen atom positions were determined from difference peaks and ultimately refined by a riding model with idealized geometry. Non-hydrogen atoms were refined with anisotropic displacement parameters. In addition to the molecule of MET-1, one molecule of diethyl ether was present in the asymmetric unit of the crystalline lattice. A total of 334 parameters were refined against 1 restraint and 4624 data to give wR2=0.0995 and S=1.040 for weights of w=1/[s2(F2) (0.0675P)2], where P=[Fo2+2Fc2]/3. The final R(F) was 0.0332 for the 4624 observed data. The largest shift/s.u. was 0.001 in the final refinement cycle and the final difference map had maxima and minima of 0.238 and −0.201 e/Å3, respectively. The absolute structure was determined by refinement of the Flack parameter, H. D. Flack, Acta Cryst. A, vol. 39, 876-881 (1983).
The three dimensional structure of MET-1 as defined by the following physical data and atomic positional parameters described and calculated herein (Tables 1-8) is illustrated in FIG. 1.
Example 2
Crystallization of (20R)-2-methylene-19-nor-22-dimethyl-1α,25-dihydroxyvitamin D3 (MET-2)
Crystallization from 2-propanol/hexane.
(20R)-2-methylene-19-nor-22-dimethyl-1α,25-dihydroxyvitamin D3 (22.7 mg), was suspended in hexane (4 mL) and then 2-propanol was added dropwise to the suspension. The mixture was heated in a water bath to dissolve the vitamin, then was left at room temperature for about 1 hour, and finally was kept in a refrigerator for about 48 hours. The precipitated crystals were filtered off, washed with a small volume of a cold (0° C.) 2-propanol/hexane (3:1) mixture, and dried to give crystalline material. It should be noted that an excess of 2-propanol should be avoided to get the point of saturation, i.e. only about 1 mole or less of 2-propanol should be added.
Experimental.
A colorless prism-shaped crystal of dimensions 0.36×0.17×0.03 mm was selected for structural analysis. Intensity data were collected using a Bruker AXS Platinum 135 CCD detector controlled with the PROTEUM software suite (Bruker AXS Inc., Madison, Wis.). The x-ray source was CuK radiation (1.54178 Å) from a Rigaku RU200 x-ray generator equipped with Montel optics, operated at 50 kV and 90 mA. The x-ray data were processed with SAINT version 7.06A (Bruker AXS Inc.) and internally scaled with SADABS version 2005/1 (Bruker AXS Inc.). The sample was mounted in a quartz capillary tube and data collected at 298 K. The intensity data were measured as a series of phi and omega oscillation frames each of 1° for 20-40 sec/frame. The detector was operated in 1024×1024 mode and was positioned 4.5 cm from the sample. Cell parameters were determined from a non-linear least squares fit of 9999 peaks in the range of 2.51<theta<58.69°. The data were merged to form a set of 3985 independent data with R(int)=0.0473.
The monoclinic space group C2 was determined by systematic absences and statistical tests and verified by subsequent refinement. The structure was solved by direct methods and refined by full-matrix least-squares methods on F2, (a) G. M. Sheldrick (1994), SHELXTL Version 5 Reference Manual, Bruker AXS Inc.; (b) International Tables for Crystallography, Vol. C, Kluwer: Boston (1995). Hydrogen atom positions were determined from difference peaks and ultimately refined by a riding model with idealized geometry. Non-hydrogen atoms were refined with anisotropic displacement parameters. In addition to the molecule of MET-2, one molecule of isopropanol was present in the asymmetric unit of the crystalline lattice. A total of 325 parameters were refined against 1 restraint and 3985 data to give wR2=0.1600 and S=1.073 for weights of w=1/[s2(F2)+(0.1033P)2], where P=[Fo2+2Fc2]/3. The final R(F) was 0.0844 for the 3985 observed data. The largest shift/s.u. was 0.001 in the final refinement cycle and the final difference map had maxima and minima of 0.140 and −0.190 e/Å3, respectively. The absolute structure was determined by refinement of the Flack parameter, H. D. Flack, Acta Cryst. A, vol. 39, 876-881 (1983).
The three dimensional structure of MET-2 as defined by the following physical data and atomic positional parameters described and calculated herein (Tables 9-16) is illustrated in FIG. 2.







TABLE 1





Crystal data and structure refinement for MET-1.

















Empirical formula
C33H58O4



Formula weight
518.79



Temperature
100(1) K



Wavelength
1.54178 Å



Crystal system, space group
Monoclinic, P2(1)



Unit cell dimensions
a = 7.5780(15)Å
α = 90°



b = 14.792(3) Å
β = 102.22(3)°



c = 14.481(3) Å
γ = 90°








Volume
1586.5(6) Å3


Z
2


Calculated density
1.086 Mg/m3


Absorption coefficient
0.532 mm−1


F(000)
576


Crystal size
0.25 × 0.34 × 0.55 mm


Theta range for data collection
3.12 to 63.06°


Limiting indices
−8 <= h <= 8, −17 <= k <= 16,



0 <= l <= 16


Reflections collected/unique
7564/4624 [R(int) = 0.0287]


Data/restraints/parameters
4624/1/334


Goodness-of-fit on F2
1.040


Final R indices [I > 2□(I)]
R1 = 0.0330, wR2 = 0.0955


R indices (all data)
R1 = 0.0332, wR2 = 0.0959


Absolute structure parameter
−0.01(15)


Largest diff. peak and hole
0.238 and −0.201 e/Å3
















TABLE 2







Atomic coordinates (Å2 × 104) and equivalent isotropic


displacement parameters (Å2 × 103) for MET-1 U(eq)


is defined as one third of the trace of the orthogonalized Uij tensor.












x
y
z
U(eq)
















O(3)
−1435(2)
3847(1)
11389(1)
26(1)



O(100)
−1576(2)
5643(1)
10959(1)
32(1)



O(25)
−4404(2)
−6333(1)
12194(1)
27(1)



O(1)
3382(2)
2361(1)
11284(1)
28(1)



C(5)
−1471(2)
1831(1)
11117(1)
22(1)



C(13)
−3621(2)
−1411(1)
13186(1)
22(1)



C(6)
−2465(2)
1391(1)
11638(1)
23(1)



C(20)
−3217(2)
−3144(1)
13759(1)
23(1)



C(14)
−2234(2)
−617(1)
13380(1)
23(1)



C(2)
716(2)
3237(1)
10539(1)
24(1)



C(22)
−2071(2)
−3839(1)
14466(1)
27(1)



C(7)
−1882(2)
618(1)
12255(1)
23(1)



C(4)
−2313(2)
2542(1)
10414(1)
24(1)



C(8)
−2850(2)
217(1)
12818(1)
24(1)



C(23)
−2980(2)
−4791(1)
14332(1)
28(1)



C(3)
−1246(2)
3423(1)
10520(1)
25(1)



C(21)
−5206(2)
−3181(1)
13826(1)
30(1)



C(24)
−3359(2)
−5161(1)
13320(1)
27(1)



C(1)
1560(2)
2561(1)
11290(1)
23(1)



C(10)
502(2)
1670(1)
11152(1)
22(1)



C(15)
−456(2)
−1058(1)
13319(1)
26(1)



C(12)
−5392(2)
−1054(1)
13413(1)
28(1)



C(9)
−4631(2)
555(1)
12982(1)
29(1)



C(17)
−2546(2)
−2145(1)
13863(1)
22(1)



C(101)
−280(3)
6264(1)
11455(1)
40(1)



C(29)
1591(3)
3619(1)
9940(1)
31(1)



C(30)
−125(2)
−3978(1)
14326(1)
31(1)



C(16)
−580(2)
−2012(1)
13723(1)
25(1)



C(18)
−3930(2)
−1723(1)
12152(1)
24(1)



C(11)
−6056(2)
−197(1)
12851(1)
29(1)



C(25)
−3972(3)
−6149(1)
13189(1)
31(1)



C(201)
−3380(3)
6000(1)
10736(1)
38(1)



C(27)
−2516(4)
−6804(2)
13656(2)
65(1)



C(28)
−1941(3)
−3553(1)
15498(1)
35(1)



C(202)
−4591(3)
5306(2)
10178(2)
48(1)



C(26)
−5726(3)
−6301(2)
13518(1)
50(1)



C(102)
1535(3)
5832(2)
11596(2)
54(1)
















TABLE 3





Bond lengths [Å] for MET-1.


















O(3)—C(3)
1.440(2)
O(100)—C(101)
1.423(2)


O(100)—C(201)
1.437(2)
O(25)—C(25)
1.435(2)


O(1)—C(1)
1.4140(19)
C(5)—C(6)
1.342(2)


C(5)—C(10)
1.504(2)
C(5)—C(4)
1.508(2)


C(13)—C(18)
1.537(2)
C(13)—C(12)
1.542(2)


C(13)—C(14)
1.561(2)
C(13)—C(17)
1.570(2)


C(6)—C(7)
1.461(2)
C(20)—C(21)
1.532(2)


C(20)—C(17)
1.559(2)
C(20)—C(22)
1.575(2)


C(14)—C(8)
1.497(2)
C(14)—C(15)
1.516(2)


C(2)—C(29)
1.325(2)
C(2)—C(3)
1.506(2)


C(2)—C(1)
1.516(2)
C(22)—C(28)
1.536(2)


C(22)—C(30)
1.544(2)
C(22)—C(23)
1.562(2)


C(7)—C(8)
1.345(2)
C(4)—C(3)
1.524(2)


C(8)—C(9)
1.505(2)
C(23)—C(24)
1.533(2)


C(24)—C(25)
1.532(2)
C(1)—C(10)
1.533(2)


C(15)—C(16)
1.539(2)
C(12)—C(11)
1.532(2)


C(9)—C(11)
1.534(2)
C(17)—C(16)
1.558(2)


C(101)—C(102)
1.491(3)
C(25)—C(27)
1.516(3)


C(25)—C(26)
1.521(3)
C(201)—C(202)
1.495(3)
















TABLE 4





Bond angles [°] for MET-1.


















C(101)—O(100)—C(201)
113.47(15)



C(6)—C(5)—C(10)
125.17(14)



C(6)—C(5)—C(4)
120.68(15)



C(10)—C(5)—C(4)
114.14(13)



C(18)—C(13)—C(12)
110.52(13)



C(18)—C(13)—C(14)
111.04(12)



C(12)—C(13)—C(14)
106.64(13)



C(18)—C(13)—C(17)
110.70(13)



C(12)—C(13)—C(17)
117.67(13)



C(14)—C(13)—C(17)
99.63(12)



C(5)—C(6)—C(7)
126.18(15)



C(21)—C(20)—C(17)
109.44(13)



C(21)—C(20)—C(22)
110.45(13)



C(17)—C(20)—C(22)
115.60(13)



C(8)—C(14)—C(15)
120.05(14)



C(8)—C(14)—C(13)
113.68(13)



C(15)—C(14)—C(13)
103.82(13)



C(29)—C(2)—C(3)
122.61(16)



C(29)—C(2)—C(1)
123.89(16)



C(3)—C(2)—C(1)
113.49(13)



C(28)—C(22)—C(30)
107.31(14)



C(28)—C(22)—C(23)
107.77(13)



C(30)—C(22)—C(23)
105.76(14)



C(28)—C(22)—C(20)
111.43(14)



C(30)—C(22)—C(20)
114.34(13)



C(23)—C(22)—C(20)
109.89(13)



C(8)—C(7)—C(6)
125.67(15)



C(5)—C(4)—C(3)
112.89(14)



C(7)—C(8)—C(14)
123.11(15)



C(7)—C(8)—C(9)
124.84(15)



C(14)—C(8)—C(9)
112.04(14)



C(24)—C(23)—C(22)
115.43(13)



O(3)—C(3)—C(2)
110.16(13)



O(3)—C(3)—C(4)
108.15(12)



C(2)—C(3)—C(4)
110.21(13)



C(25)—C(24)—C(23)
116.71(14)



O(1)—C(1)—C(2)
113.40(13)



O(1)—C(1)—C(10)
107.71(12)



C(2)—C(1)—C(10)
110.12(13)



C(5)—C(10)—C(1)
110.88(13)



C(14)—C(15)—C(16)
104.17(13)



C(11)—C(12)—C(13)
111.93(13)



C(8)—C(9)—C(11)
111.72(14)



C(20)—C(17)—C(16)
114.06(13)



C(20)—C(17)—C(13)
118.64(13)



C(16)—C(17)—C(13)
102.46(12)



O(100)—C(101)—C(102)
108.10(16)



C(15)—C(16)—C(17)
107.60(13)



C(12)—C(11)—C(9)
113.01(14)



O(25)—C(25)—C(27)
108.39(16)



O(25)—C(25)—C(26)
104.95(14)



C(27)—C(25)—C(26)
111.5(2)



O(25)—C(25)—C(24)
107.75(13)



C(27)—C(25)—C(24)
112.43(16)



C(26)—C(25)—C(24)
111.40(16)



O(100)—C(201)—C(202)
108.38(16)
















TABLE 5







Anisotropic displacement parameters (Å2 × 103) for MET-1.


The anisotropic displacement factor exponent takes the form:


−2π2[h2a * 2U11 + . . . + 2hka * b * U12.














U11
U22
U33
U23
U13
U12





O(3)
26(1)
17(1)
37(1)
0(1)
10(1)
1(1)


O(100)
40(1)
19(1)
37(1)
2(1)
9(1)
3(1)


O(25)
28(1)
28(1)
26(1)
−2(1)
6(1)
−7(1)


O(1)
17(1)
23(1)
44(1)
−6(1)
8(1)
−2(1)


C(5)
21(1)
16(1)
27(1)
−4(1)
4(1)
−2(1)


C(13)
23(1)
21(1)
24(1)
0(1)
8(1)
−2(1)


C(6)
19(1)
18(1)
32(1)
−2(1)
6(1)
0(1)


C(20)
28(1)
20(1)
23(1)
1(1)
8(1)
−5(1)


C(14)
25(1)
20(1)
25(1)
−2(1)
6(1)
−3(1)


C(2)
27(1)
17(1)
29(1)
−5(1)
7(1)
−4(1)


C(22)
33(1)
22(1)
24(1)
3(1)
4(1)
−6(1)


C(7)
19(1)
18(1)
30(1)
−2(1)
6(1)
−1(1)


C(4)
21(1)
21(1)
30(1)
1(1)
3(1)
1(1)


C(8)
25(1)
18(1)
29(1)
−3(1)
6(1)
−1(1)


C(23)
38(1)
21(1)
25(1)
3(1)
6(1)
−5(1)


C(3)
29(1)
20(1)
28(1)
4(1)
7(1)
2(1)


C(21)
29(1)
23(1)
39(1)
2(1)
11(1)
−6(1)


C(24)
34(1)
22(1)
24(1)
2(1)
6(1)
−4(1)


C(1)
20(1)
22(1)
29(1)
−2(1)
8(1)
0(1)


C(10)
21(1)
20(1)
27(1)
2(1)
7(1)
2(1)


C(15)
20(1)
23(1)
33(1)
3(1)
4(1)
−3(1)


C(12)
29(1)
24(1)
34(1)
1(1)
14(1)
−2(1)


C(9)
30(1)
24(1)
38(1)
2(1)
16(1)
4(1)


C(17)
25(1)
20(1)
20(1)
0(1)
6(1)
−4(1)


C(101)
65(1)
25(1)
29(1)
−1(1)
10(1)
−9(1)


C(29)
33(1)
24(1)
39(1)
3(1)
13(1)
−2(1)


C(30)
33(1)
23(1)
36(1)
9(1)
1(1)
−1(1)


C(16)
22(1)
21(1)
29(1)
2(1)
1(1)
−2(1)


C(18)
25(1)
20(1)
26(1)
0(1)
4(1)
−1(1)


C(11)
25(1)
28(1)
39(1)
3(1)
16(1)
3(1)


C(25)
42(1)
23(1)
25(1)
2(1)
1(1)
−6(1)


C(201)
48(1)
28(1)
44(1)
11(1)
22(1)
15(1)


C(27)
93(2)
25(1)
55(1)
0(1)
−32(1)
8(1)


C(28)
49(1)
29(1)
26(1)
2(1)
4(1)
−12(1)


C(202)
35(1)
46(1)
58(1)
14(1)
2(1)
13(1)


C(26)
75(2)
50(1)
31(1)
−7(1)
23(1)
−34(1)


C(102)
54(1)
41(1)
57(1)
2(1)
−10(1)
−14(1)
















TABLE 6





Hydrogen coordinates (Å2 × 104) and isotropic


displacement parameters (Å2 × 103) for MET-1.





















H(3A)
−1246
4391
11360
40



H(25A)
−3854
−5981
11920
41



H(1A)
4033
2763
11559
41



H(6A)
−3636
1598
11604
27



H(20F)
−3157
−3339
13120
28



H(14A)
−2129
−451
14045
28



H(7A)
−743
383
12258
27



H(4A)
−3529
2665
10495
29



H(4B)
−2398
2310
9780
29



H(23A)
−2206
−5217
14739
34



H(23B)
−4112
−4761
14542
34



H(3B)
−1735
3823
9988
30



H(21A)
−5886
−2755
13392
45



H(21B)
−5311
−3033
14458
45



H(21C)
−5668
−3779
13671
45



H(24A)
−4282
−4787
12936
40



H(24B)
−2270
−5094
13075
40



H(1B)
1502
2809
11910
28



H(10F)
646
1386
10569
27



H(10G)
983
1262
11669
27



H(15A)
554
−727
13690
31



H(15B)
−316
−1087
12669
31



H(12A)
−6313
−1518
13267
33



H(12B)
−5200
−923
14084
33



H(9A)
−5058
1043
12544
35



H(9B)
−4464
795
13618
35



H(17A)
−2559
−1957
14511
26



H(10A)
−557
6412
12061
48



H(10B)
−298
6817
11094
48



H(29A)
994
4020
9485
37



H(29B)
2803
3486
9975
37



H(30A)
485
−4408
14780
47



H(30B)
509
−3412
14411
47



H(30C)
−160
−4201
13700
47



H(16A)
271
−2075
14322
30



H(16B)
−299
−2463
13290
30



H(18A)
−4591
−1267
11750
35



H(18B)
−4607
−2276
12077
35



H(18C)
−2787
−1820
11983
35



H(11A)
−7122
26
13048
35



H(11B)
−6400
−349
12186
35



H(20A)
−3409
6551
10371
46



H(20B)
−3782
6139
11313
46



H(27A)
−1429
−6689
13435
97



H(27B)
−2910
−7412
13498
97



H(27C)
−2288
−6726
14328
97



H(28A)
−1234
−3988
15910
53



H(28B)
−3130
−3522
15627
53



H(28C)
−1377
−2970
15600
53



H(20C)
−5804
5534
10022
71



H(20D)
−4560
4764
10546
71



H(20E)
−4187
5175
9607
71



H(26A)
−6077
−6924
13425
75



H(26B)
−6654
−5923
13161
75



H(26C)
−5554
−6154
14177
75



H(10C)
2433
6241
11927
81



H(10D)
1798
5688
10993
81



H(10E)
1544
5288
11958
















TABLE 7





Torsion angles [deg] for MET-1.


















C(10)—C(5)—C(6)—C(7)
−6.9(3)



C(4)—C(5)—C(6)—C(7)
172.04(14)



C(18)—C(13)—C(14)—C(8)
62.64(17)



C(12)—C(13)—C(14)—C(8)
−57.81(17)



C(17)—C(13)—C(14)—C(8)
179.34(12)



C(18)—C(13)—C(14)—C(15)
−69.49(16)



C(12)—C(13)—C(14)—C(15)
170.05(13)



C(17)—C(13)—C(14)—C(15)
47.21(14)



C(21)—C(20)—C(22)—C(28)
−68.60(17)



C(17)—C(20)—C(22)—C(28)
56.32(18)



C(21)—C(20)—C(22)—C(30)
169.50(14)



C(17)—C(20)—C(22)—C(30)
−65.58(18)



C(21)—C(20)—C(22)—C(23)
50.77(17)



C(17)—C(20)—C(22)—C(23)
175.69(13)



C(5)—C(6)—C(7)—C(8)
175.69(16)



C(6)—C(5)—C(4)—C(3)
129.93(16)



C(10)—C(5)—C(4)—C(3)
−50.98(18)



C(6)—C(7)—C(8)—C(14)
175.28(14)



C(6)—C(7)—C(8)—C(9)
−6.4(3)



C(15)—C(14)—C(8)—C(7)
−0.9(2)



C(13)—C(14)—C(8)—C(7)
−124.65(17)



C(15)—C(14)—C(8)—C(9)
−179.41(15)



C(13)—C(14)—C(8)—C(9)
56.87(17)



C(28)—C(22)—C(23)—C(24)
175.53(15)



C(30)—C(22)—C(23)—C(24)
−69.94(18)



C(20)—C(22)—C(23)—C(24)
53.94(19)



C(29)—C(2)—C(3)—O(3)
−116.79(17)



C(1)—C(2)—C(3)—O(3)
64.38(16)



C(29)—C(2)—C(3)—C(4)
123.95(17)



C(1)—C(2)—C(3)—C(4)
−54.88(17)



C(5)—C(4)—C(3)—O(3)
−69.91(16)



C(5)—C(4)—C(3)—C(2)
50.56(17)



C(22)—C(23)—C(24)—C(25)
170.72(15)



C(29)—C(2)—C(1)—O(1)
−1.0(2)



C(3)—C(2)—C(1)—O(1)
177.82(12)



C(29)—C(2)—C(1)—C(10)
−121.76(17)



C(3)—C(2)—C(1)—C(10)
57.05(16)



C(6)—C(5)—C(10)—C(1)
−128.78(16)



C(4)—C(5)—C(10)—C(1)
52.18(17)



O(1)—C(1)—C(10)—C(5)
−178.02(11)



C(2)—C(1)—C(10)—C(5)
−53.90(16)



C(8)—C(14)—C(15)—C(16)
−163.10(13)



C(13)—C(14)—C(15)—C(16)
−34.78(16)



C(18)—C(13)—C(12)—C(11)
−65.07(17)



C(14)—C(13)—C(12)—C(11)
55.72(17)



C(17)—C(13)—C(12)—C(11)
166.45(14)



C(7)—C(8)—C(9)—C(11)
130.33(18)



C(14)—C(8)—C(9)—C(11)
−51.22(17)



C(21)—C(20)—C(17)—C(16)
−175.23(13)



C(22)—C(20)—C(17)—C(16)
59.33(17)



C(21)—C(20)—C(17)—C(13)
−54.36(17)



C(22)—C(20)—C(17)—C(13)
−179.80(12)



C(18)—C(13)—C(17)—C(20)
−50.06(18)



C(12)—C(13)—C(17)—C(20)
78.34(18)



C(14)—C(13)—C(17)—C(20)
−167.02(12)



C(18)—C(13)—C(17)—C(16)
76.56(15)



C(12)—C(13)—C(17)—C(16)
−155.04(14)



C(14)—C(13)—C(17)—C(16)
−40.40(14)



C(201)—O(100)—C(101)—C(102)
−177.01(16)



C(14)—C(15)—C(16)—C(17)
8.55(16)



C(20)—C(17)—C(16)—C(15)
150.05(13)



C(13)—C(17)—C(16)—C(15)
20.53(16)



C(13)—C(12)—C(11)—C(9)
−54.82(19)



C(8)—C(9)—C(11)—C(12)
50.78(18)



C(23)—C(24)—C(25)—O(25)
175.01(14)



C(23)—C(24)—C(25)—C(27)
−65.6(2)



C(23)—C(24)—C(25)—C(26)
60.4(2)



C(101)—O(100)—C(201)—C(202)
177.20(15)
















TABLE 8







Observed and calculated structure factors for MET-1.




































h
k
l
10Fo
10Fc
10s
h
k
l
10Fo
10Fc
10s
h
k
l
10Fo
10Fc
10s
h
k
l
10Fo
10Fc
10s
h
k
l
10Fo
10Fc
10s







































0
−16
0
150
149
2
1
2
0
479
489
5
2
15
0
41
44
1
3
−9
1
37
37
1
4
1
1
139
136
2


1
−16
0
52
52
1
2
2
0
217
210
2
3
15
0
34
36
1
4
−9
1
188
187
3
5
1
1
75
72
1


2
−16
0
77
74
1
3
2
0
118
120
1
4
15
0
95
95
1
5
−9
1
192
181
3
6
1
1
131
124
2


3
−16
0
134
137
2
4
2
0
253
245
3
2
16
0
76
74
1
6
−9
1
3
6
3
7
1
1
154
157
2


1
−15
0
106
109
1
5
2
0
56
51
1
0
−17
1
74
72
1
−6
−8
1
25
23
1
8
1
1
21
20
1


2
−15
0
44
45
1
6
2
0
195
199
3
−3
−16
1
41
39
1
−5
−8
1
142
141
2
−8
2
1
47
49
1


3
−15
0
34
36
1
7
2
0
79
74
1
−2
−16
1
75
77
1
−4
−8
1
24
21
1
−7
2
1
143
145
2


4
−15
0
91
94
1
8
2
0
50
49
1
−1
−16
1
5
5
4
−3
−8
1
44
43
1
−6
2
1
40
38
1


0
−14
0
137
148
1
1
3
0
141
142
1
0
−16
1
51
50
1
−2
−8
1
66
64
1
−5
2
1
46
49
1


1
−14
0
18
16
1
2
3
0
272
281
3
1
−16
1
167
170
1
−1
−8
1
103
98
1
−4
2
1
59
51
1


2
−14
0
98
96
1
3
3
0
252
247
3
2
−16
1
4
6
4
0
−8
1
149
161
3
−3
2
1
448
429
5


3
−14
0
110
106
1
4
3
0
55
60
1
−4
−15
1
112
113
2
1
−8
1
187
189
2
−2
2
1
146
146
1


4
−14
0
22
21
1
5
3
0
70
68
1
−3
−15
1
114
109
1
2
−8
1
160
151
1
−1
2
1
328
333
3


1
−13
0
104
107
1
6
3
0
151
145
2
−2
−15
1
105
99
1
3
−8
1
88
80
1
0
2
1
275
279
4


2
−13
0
74
72
1
7
3
0
72
70
1
−1
−15
1
63
66
1
4
−8
1
203
198
3
1
2
1
372
371
4


3
−13
0
102
95
1
8
3
0
30
33
1
0
−15
1
57
53
1
5
−8
1
115
116
2
2
2
1
189
195
2


4
−13
0
123
117
2
0
4
0
924
916
22
1
−15
1
39
39
1
6
−8
1
27
27
1
3
2
1
167
170
2


5
−13
0
41
42
1
1
4
0
319
318
4
2
−15
1
72
73
1
−4
−7
1
268
270
5
4
2
1
66
71
1


0
−12
0
43
42
1
2
4
0
399
410
4
3
−15
1
48
46
1
−3
−7
1
110
109
1
5
2
1
63
65
1


1
−12
0
76
72
1
3
4
0
250
245
3
−5
−14
1
57
62
1
−2
−7
1
153
142
1
6
2
1
123
120
2


2
−12
0
67
63
1
4
4
0
87
81
1
−4
−14
1
66
72
1
−1
−7
1
391
378
5
7
2
1
130
133
2


3
−12
0
44
40
1
5
4
0
153
154
1
−3
−14
1
7
10
3
0
−7
1
185
171
2
8
2
1
56
50
1


4
−12
0
75
86
1
6
4
0
31
38
1
−2
−14
1
49
45
1
1
−7
1
354
336
4
−8
3
1
22
20
1


5
−12
0
79
74
1
7
4
0
69
74
1
−1
−14
1
63
65
1
2
−7
1
236
227
2
−7
3
1
101
95
1


6
−12
0
66
61
1
8
4
0
12
18
1
0
−14
1
34
35
1
3
−7
1
211
209
3
−6
3
1
74
74
1


1
−11
0
88
88
1
1
5
0
48
55
1
1
−14
1
83
88
1
−3
−6
1
480
451
5
−5
3
1
117
119
1


2
−11
0
105
103
1
2
5
0
241
222
3
2
−14
1
31
30
1
−2
−6
1
598
575
6
−4
3
1
251
235
3


3
−11
0
158
162
1
3
5
0
163
165
2
3
−14
1
10
8
2
−1
−6
1
152
146
1
−3
3
1
143
128
1


4
−11
0
50
52
1
4
5
0
158
167
1
4
−14
1
26
28
1
0
−6
1
303
302
4
−2
3
1
191
189
2


5
−11
0
133
130
2
5
5
0
89
87
1
−5
−13
1
125
128
2
1
−6
1
562
533
6
−1
3
1
406
413
6


6
−11
0
18
22
1
6
5
0
192
193
3
−4
−13
1
41
41
1
2
−6
1
254
234
2
0
3
1
293
280
5


0
−10
0
186
194
1
7
5
0
43
42
1
−3
−13
1
76
76
1
−3
−5
1
126
122
3
1
3
1
364
373
4


1
−10
0
65
57
1
8
5
0
35
37
1
−2
−13
1
57
52
1
−2
−5
1
54
55
1
2
3
1
242
241
2


2
−10
0
167
171
1
0
6
0
382
366
8
−1
−13
1
137
144
1
−1
−5
1
358
351
3
3
3
1
275
287
5


3
−10
0
238
244
1
1
6
0
453
436
8
0
−13
1
91
97
1
0
−5
1
275
275
2
4
3
1
137
135
1


4
−10
0
158
152
2
3
6
0
312
309
4
1
−13
1
193
196
1
1
−5
1
58
66
1
5
3
1
36
39
1


5
−10
0
96
90
1
4
6
0
232
222
1
2
−13
1
199
205
1
2
−5
1
37
36
1
6
3
1
134
135
2


6
−10
0
92
92
1
5
6
0
158
155
1
3
−13
1
82
85
1
−3
−4
1
406
386
10
7
3
1
84
81
1


1
−9
0
185
185
1
6
6
0
170
175
2
4
−13
1
29
27
1
−2
−4
1
198
185
2
8
3
1
45
44
1


2
−9
0
171
177
1
7
6
0
138
133
2
5
−13
1
23
21
1
−1
−4
1
367
368
3
−8
4
1
37
38
1


3
−9
0
86
87
1
8
6
0
57
61
1
−6
−12
1
40
39
1
0
−4
1
229
233
1
−7
4
1
113
118
2


4
−9
0
185
178
3
1
7
0
256
225
4
−5
−12
1
80
74
1
1
−4
1
508
500
5
−6
4
1
116
116
2


5
−9
0
128
130
2
2
7
0
113
122
3
−4
−12
1
88
92
1
2
−4
1
242
228
2
−5
4
1
108
109
1


6
−9
0
53
55
1
3
7
0
87
95
1
−3
−12
1
64
66
1
−3
−3
1
146
127
3
−4
4
1
69
60
1


0
−8
0
262
252
6
4
7
0
119
119
1
−2
−12
1
170
176
1
−2
−3
1
189
189
2
−3
4
1
402
384
6


1
−8
0
168
164
2
5
7
0
180
184
1
−1
−12
1
151
147
1
−1
−3
1
403
412
4
−2
4
1
191
185
2


2
−8
0
44
41
1
6
7
0
25
23
1
0
−12
1
147
146
1
0
−3
1
289
281
2
−1
4
1
365
367
4


3
−8
0
155
149
1
7
7
0
73
73
1
1
−12
1
39
40
1
1
−3
1
377
373
3
0
4
1
227
233
4


4
−8
0
232
231
4
0
8
0
267
253
6
2
−12
1
125
128
1
2
−3
1
240
242
2
1
4
1
504
501
8


5
−8
0
120
115
2
1
8
0
170
164
4
3
−12
1
93
94
1
−2
−2
1
142
145
1
2
4
1
236
228
2


6
−8
0
88
85
1
2
8
0
41
41
1
4
−12
1
30
34
1
−1
−2
1
330
333
3
3
4
1
315
294
4


1
−7
0
254
225
3
3
8
0
154
150
1
5
−12
1
40
35
1
0
−2
1
274
279
2
4
4
1
235
230
2


2
−7
0
120
123
1
4
8
0
231
231
2
−6
−11
1
81
84
1
1
−2
1
375
372
3
5
4
1
243
242
1


3
−7
0
89
96
1
5
8
0
118
115
1
−5
−11
1
66
65
1
2
−2
1
186
196
4
6
4
1
79
80
1


0
−6
0
346
368
9
6
8
0
87
85
1
−4
−11
1
36
33
1
−8
−1
1
23
27
1
7
4
1
48
50
1


1
−6
0
458
436
4
7
8
0
56
57
1
−3
−11
1
10
12
1
−7
−1
1
107
107
1
8
4
1
53
57
1


2
−6
0
246
233
2
1
9
0
180
185
3
−2
−11
1
113
112
1
−2
−1
1
44
48
1
−8
5
1
75
75
1


3
−6
0
318
309
7
2
9
0
171
176
2
−1
−11
1
122
122
1
−1
−1
1
228
240
2
−7
5
1
131
135
2


1
−5
0
47
53
1
3
9
0
87
88
1
0
−11
1
120
110
1
0
−1
1
99
95
1
−6
5
1
218
238
2


2
−5
0
247
222
2
4
9
0
186
178
2
1
−11
1
138
138
1
1
−1
1
339
344
3
−5
5
1
131
120
1


3
−5
0
168
164
4
5
9
0
129
130
1
2
−11
1
268
266
2
2
−1
1
364
386
9
−4
5
1
106
117
1


0
−4
0
922
916
10
6
9
0
50
55
1
3
−11
1
126
119
1
7
−1
1
151
157
2
−3
5
1
129
121
2


1
−4
0
324
317
3
1
10
0
66
57
1
4
−11
1
163
163
2
−8
0
1
6
0
3
−2
5
1
53
56
1


2
−4
0
405
410
4
2
10
0
168
171
2
5
−11
1
35
36
1
−7
0
1
63
70
1
−1
5
1
357
351
4


1
−3
0
141
141
1
3
10
0
237
243
2
6
−11
1
31
32
1
−6
0
1
57
60
1
0
5
1
274
276
4


2
−3
0
269
280
2
4
10
0
154
152
1
−6
−10
1
83
81
1
−3
0
1
226
236
3
1
5
1
57
67
1


0
−2
0
115
113
2
5
10
0
96
90
1
−5
−10
1
166
167
3
−2
0
1
5
9
5
2
5
1
38
37
1


1
−2
0
485
488
5
6
10
0
91
93
1
−4
−10
1
217
215
3
−1
0
1
526
532
5
3
5
1
288
270
4


2
−2
0
217
210
5
1
11
0
90
90
1
−3
−10
1
214
216
1
0
0
1
128
131
1
4
5
1
266
273
2


1
−1
0
460
471
11
2
11
0
105
103
2
−2
−10
1
169
175
1
1
0
1
1440
1454
16
5
5
1
303
307
2


2
−1
0
239
259
6
3
11
0
157
162
2
−1
−10
1
136
145
1
2
0
1
78
75
1
6
5
1
46
52
1


7
−1
0
120
126
2
4
11
0
50
52
1
0
−10
1
287
290
1
3
0
1
393
391
6
7
5
1
92
93
1


1
0
0
86
93
1
5
11
0
133
130
1
1
−10
1
188
180
1
6
0
1
101
102
1
8
5
1
23
28
1


2
0
0
181
158
2
6
11
0
19
22
1
2
−10
1
145
142
1
7
0
1
61
65
1
−8
6
1
61
65
1


3
0
0
173
170
4
3
12
0
44
40
1
3
−10
1
91
93
1
8
0
1
57
56
1
−7
6
1
27
30
1


6
0
0
105
106
1
4
12
0
79
86
1
4
−10
1
119
109
2
−8
1
1
24
27
1
−6
6
1
112
110
1


7
0
0
25
20
1
5
12
0
79
75
1
5
−10
1
67
70
1
−7
1
1
110
107
1
−5
6
1
243
241
3


8
0
0
30
34
1
6
12
0
65
62
1
6
−10
1
42
43
1
−6
1
1
63
58
1
−4
6
1
77
84
1


1
1
0
467
471
5
1
13
0
107
107
2
−6
−9
1
32
35
1
−5
1
1
25
23
1
−3
6
1
484
451
11


2
1
0
253
258
2
2
13
0
77
73
1
−5
−9
1
111
105
2
−4
1
1
311
301
5
−2
6
1
552
575
15


3
1
0
275
267
5
3
13
0
102
95
1
−4
−9
1
22
25
1
−3
1
1
570
528
6
−1
6
1
151
146
2


4
1
0
406
383
7
4
13
0
125
117
1
−3
−9
1
123
121
1
−2
1
1
46
49
1
0
6
1
309
301
5


5
1
0
126
127
2
5
13
0
41
42
1
−2
−9
1
98
101
1
−1
1
1
230
240
2
1
6
1
560
533
9


6
1
0
218
223
3
1
14
0
21
17
2
−1
−9
1
28
17
1
0
1
1
95
94
1
2
6
1
243
234
6


7
1
0
121
126
2
2
14
0
100
96
2
0
−9
1
349
341
2
1
1
1
325
343
6
3
6
1
44
56
1


8
1
0
26
24
1
3
14
0
113
106
1
1
−9
1
96
94
1
2
1
1
372
386
4
4
6
1
178
179
1


0
2
0
115
112
3
4
14
0
25
21
1
2
−9
1
59
51
1
3
1
1
248
249
3
5
6
1
100
100
1


6
6
1
178
184
3
−3
14
1
11
9
2
−7
−9
2
46
48
1
3
0
2
62
71
1
−7
6
2
29
26
1


7
6
1
61
60
1
−2
14
1
49
45
1
−6
−9
2
62
62
1
6
0
2
88
96
1
−6
6
2
107
103
1


−7
7
1
13
13
1
1
14
1
86
88
2
−5
−9
2
30
26
1
7
0
2
77
80
1
−5
6
2
99
101
1


−6
7
1
80
84
1
2
14
1
33
30
1
−4
−9
2
210
206
3
8
0
2
25
23
1
−4
6
2
232
229
1


−5
7
1
233
226
2
3
14
1
10
9
2
−3
−9
2
100
97
1
−8
1
2
15
15
1
−3
6
2
247
241
6


−4
7
1
275
271
2
4
14
1
29
29
1
−2
−9
2
136
142
1
−7
1
2
152
155
2
−2
6
2
380
388
10


−3
7
1
109
109
1
−4
15
1
116
113
2
−1
−9
2
156
157
1
−6
1
2
106
102
1
−1
6
2
213
187
3


−2
7
1
148
142
4
−3
15
1
117
109
1
0
−9
2
97
107
1
−5
1
2
133
137
2
0
6
2
193
179
4


−1
7
1
393
379
6
−2
15
1
104
99
1
1
−9
2
165
164
1
−4
1
2
163
167
2
1
6
2
273
253
5


0
7
1
189
170
3
2
15
1
73
74
1
2
−9
2
273
274
2
−3
1
2
497
473
5
3
6
2
130
136
1


1
7
1
350
336
9
3
15
1
49
46
1
3
−9
2
61
61
1
−2
1
2
212
218
2
4
6
2
263
274
2


2
7
1
234
227
6
−3
16
1
42
39
1
4
−9
2
174
169
3
−1
1
2
664
676
7
5
6
2
107
98
1


3
7
1
212
208
2
−2
16
1
75
77
1
5
−9
2
111
109
2
0
1
2
1028
1060
13
6
6
2
71
75
1


4
7
1
109
108
1
2
16
1
9
6
2
6
−9
2
57
54
1
1
1
2
470
471
5
7
6
2
27
33
1


5
7
1
119
122
1
−3
−16
2
5
2
5
−6
−8
2
55
56
1
2
1
2
101
101
1
−7
7
2
80
80
1


6
7
1
87
89
1
−2
−16
2
101
95
1
−5
−8
2
211
206
3
3
1
2
115
109
1
−6
7
2
102
97
1


7
7
1
23
22
1
−1
−16
2
96
93
1
−4
−8
2
61
65
1
4
1
2
96
103
1
−5
7
2
136
141
1


−7
8
1
30
28
1
0
−16
2
59
57
1
−3
−8
2
122
111
1
5
1
2
64
65
1
−4
7
2
131
128
1


−6
8
1
25
23
1
1
−16
2
39
37
1
−2
−8
2
181
189
1
6
1
2
23
24
1
−3
7
2
133
133
1


−5
8
1
140
141
1
2
−16
2
29
31
1
−1
−8
2
227
225
3
7
1
2
46
44
1
−2
7
2
132
127
4


−4
8
1
25
20
1
−4
−15
2
22
26
1
0
−8
2
47
44
2
8
1
2
16
19
1
−1
7
2
160
135
3


−3
8
1
43
43
1
−3
−15
2
153
147
1
1
−8
2
177
185
1
−8
2
2
26
24
1
0
7
2
266
257
6


−2
8
1
67
64
1
−2
−15
2
75
71
1
2
−8
2
154
153
1
−7
2
2
28
29
1
1
7
2
56
54
2


−1
8
1
103
99
3
−1
−15
2
109
111
1
3
−8
2
140
133
2
−6
2
2
168
167
2
3
7
2
216
211
1


0
8
1
152
161
3
0
−15
2
119
118
1
4
−8
2
127
131
2
−5
2
2
132
134
1
4
7
2
184
197
1


1
8
1
182
190
5
1
−15
2
55
53
1
5
−8
2
249
255
4
−4
2
2
230
224
2
5
7
2
37
32
1


2
8
1
165
151
2
2
−15
2
27
28
1
6
−8
2
56
53
1
−3
2
2
365
363
4
6
7
2
93
91
1


3
8
1
86
79
1
3
−15
2
94
97
1
−6
−7
2
100
97
1
−2
2
2
142
150
1
7
7
2
64
63
1


4
8
1
200
197
1
−5
−14
2
64
62
1
−5
−7
2
135
141
2
−1
2
2
642
650
8
−7
8
2
54
49
1


5
8
1
116
116
1
−4
−14
2
115
114
1
−4
−7
2
131
127
2
0
2
2
581
595
10
−6
8
2
55
56
1


6
8
1
29
28
1
−3
−14
2
50
50
1
−3
−7
2
133
133
1
1
2
2
169
179
1
−5
8
2
209
206
2


7
8
1
42
44
1
−2
−14
2
70
71
1
−2
−7
2
133
127
1
2
2
2
349
336
4
−4
8
2
63
65
1


−6
9
1
32
35
1
−1
−14
2
48
52
1
−1
−7
2
160
135
2
3
2
2
120
113
1
−3
8
2
122
111
1


−5
9
1
111
105
1
0
−14
2
52
50
1
0
−7
2
252
255
3
4
2
2
102
107
1
−2
8
2
181
189
2


−4
9
1
23
24
1
1
−14
2
111
116
1
1
−7
2
58
54
1
5
2
2
195
196
3
−1
8
2
225
224
6


−3
9
1
121
121
1
2
−14
2
45
47
1
2
−7
2
149
153
1
6
2
2
141
139
2
0
8
2
49
44
3


−2
9
1
96
101
1
3
−14
2
23
23
1
3
−7
2
214
211
4
7
2
2
79
80
1
2
8
2
146
154
2


−1
9
1
28
17
1
4
−14
2
46
44
1
4
−7
2
182
198
3
8
2
2
27
24
1
3
8
2
142
133
1


0
9
1
357
341
6
−5
−13
2
25
21
1
−3
−6
2
247
241
3
−8
3
2
43
42
1
4
8
2
128
131
1


1
9
1
99
95
1
−4
−13
2
169
174
3
−2
−6
2
399
389
4
−7
3
2
130
126
2
5
8
2
253
255
3


2
9
1
56
51
1
−3
−13
2
87
89
1
−1
−6
2
207
187
2
−6
3
2
181
168
3
6
8
2
56
53
1


3
9
1
38
37
1
−2
−13
2
234
237
1
0
−6
2
187
178
2
−5
3
2
166
161
1
7
8
2
67
68
1


4
9
1
187
187
2
−1
−13
2
94
92
1
1
−6
2
277
253
3
−4
3
2
425
403
5
−6
9
2
61
63
1


5
9
1
187
181
1
0
−13
2
97
100
1
2
−6
2
303
285
3
−3
3
2
152
139
1
−5
9
2
34
27
1


6
9
1
8
6
1
1
−13
2
83
89
1
−3
−5
2
127
125
1
−2
3
2
176
184
1
−4
9
2
210
206
2


−6
10
1
86
81
1
2
−13
2
129
131
1
−2
−5
2
73
68
1
−1
3
2
512
520
6
−3
9
2
100
97
1


−5
10
1
165
166
2
3
−13
2
111
110
1
−1
−5
2
83
81
1
0
3
2
456
458
7
−2
9
2
137
143
2


−4
10
1
212
214
2
4
−13
2
116
112
2
0
−5
2
512
508
5
1
3
2
676
684
7
−1
9
2
153
157
2


−3
10
1
212
216
2
5
−13
2
76
75
1
1
−5
2
219
202
2
2
3
2
160
155
2
0
9
2
101
108
2


−2
10
1
172
175
2
−6
−12
2
81
76
1
2
−5
2
298
295
3
3
3
2
132
114
1
2
9
2
274
274
4


−1
10
1
134
145
2
−5
−12
2
50
50
1
−3
−4
2
143
136
2
4
3
2
117
125
1
3
9
2
61
61
1


1
10
1
186
180
3
−4
−12
2
93
90
1
−2
−4
2
186
180
2
5
3
2
83
90
1
4
9
2
170
169
1


3
10
1
91
93
1
−3
−12
2
128
127
1
−1
−4
2
314
312
2
6
3
2
175
174
3
5
9
2
106
109
1


4
10
1
111
109
1
−2
−12
2
112
118
1
0
−4
2
99
102
1
7
3
2
77
78
1
6
9
2
56
53
1


5
10
1
68
69
1
−1
−12
2
83
79
1
1
−4
2
795
786
8
8
3
2
22
21
1
−6
10
2
97
97
1


6
10
1
42
43
1
0
−12
2
161
166
1
2
−4
2
299
283
3
−8
4
2
39
36
1
−5
10
2
120
117
2


−6
11
1
81
84
1
1
−12
2
116
112
1
−3
−3
2
146
137
2
−7
4
2
51
62
1
−4
10
2
153
163
2


−5
11
1
67
65
1
2
−12
2
23
28
1
−2
−3
2
176
184
1
−6
4
2
279
284
4
−3
10
2
31
35
1


−4
11
1
33
32
1
3
−12
2
92
101
1
−1
−3
2
514
520
5
−5
4
2
113
114
1
−2
10
2
182
185
2


−3
11
1
12
11
2
4
−12
2
70
68
1
0
−3
2
453
459
4
−4
4
2
99
98
1
−1
10
2
20
14
2


−2
11
1
116
111
2
5
−12
2
53
52
1
1
−3
2
693
684
7
−3
4
2
142
136
2
0
10
2
146
148
4


−1
11
1
118
121
2
−6
−11
2
77
74
1
2
−3
2
159
156
1
−2
4
2
191
181
2
1
10
2
203
208
3


2
11
1
263
266
5
−5
−11
2
52
52
1
−3
−2
2
348
364
4
−1
4
2
315
313
4
2
10
2
53
51
1


3
11
1
128
118
1
−4
−11
2
20
28
1
−2
−2
2
144
150
1
0
4
2
99
103
2
3
10
2
93
91
1


4
11
1
159
163
1
−3
−11
2
143
140
1
−1
−2
2
644
650
6
1
4
2
774
787
19
4
10
2
63
65
1


5
11
1
35
35
1
−2
−11
2
159
158
1
0
−2
2
579
595
5
3
4
2
65
68
1
5
10
2
93
94
1


6
11
1
33
33
1
−1
−11
2
107
107
1
1
−2
2
170
180
1
4
4
2
96
97
1
6
10
2
73
75
1


−6
12
1
38
38
1
0
−11
2
161
161
1
2
−2
2
344
337
3
5
4
2
175
172
1
−6
11
2
75
73
1


−5
12
1
78
74
1
1
−11
2
176
181
1
−8
−1
2
14
15
1
6
4
2
74
80
1
−5
11
2
52
52
1


−4
12
1
92
92
1
2
−11
2
91
94
1
−7
−1
2
149
155
2
7
4
2
54
58
1
−4
11
2
26
29
1


−3
12
1
64
65
1
3
−11
2
101
106
1
−3
−1
2
483
472
5
8
4
2
14
17
1
−3
11
2
140
140
2


−2
12
1
169
176
3
4
−11
2
54
58
1
−2
−1
2
215
218
2
−8
5
2
63
61
1
−2
11
2
161
159
2


−1
12
1
151
147
3
5
−11
2
10
12
2
−1
−1
2
666
677
7
−7
5
2
52
56
1
−1
11
2
105
106
2


1
12
1
37
40
1
6
−11
2
40
46
1
0
−1
2
1043
1061
10
−6
5
2
316
313
3
1
11
2
178
181
2


2
12
1
123
127
2
−6
−10
2
97
96
1
1
−1
2
471
472
4
−5
5
2
248
251
1
2
11
2
90
94
1


3
12
1
92
95
1
−5
−10
2
118
117
2
2
−1
2
99
101
1
−4
5
2
70
71
1
3
11
2
104
106
1


4
12
1
34
35
1
−4
−10
2
157
162
2
7
−1
2
45
44
1
−3
5
2
125
127
2
4
11
2
57
58
1


5
12
1
39
36
1
−3
−10
2
36
36
1
−8
0
2
24
24
1
−2
5
2
73
68
2
5
11
2
10
13
2


−5
13
1
129
128
1
−2
−10
2
181
185
1
−7
0
2
49
50
1
−1
5
2
83
80
1
−6
12
2
81
76
1


−4
13
1
41
41
1
−1
−10
2
22
15
1
−6
0
2
240
262
4
0
5
2
518
509
12
−5
12
2
49
49
1


−3
13
1
75
76
1
0
−10
2
154
148
1
−4
0
2
543
562
10
1
5
2
214
202
2
−4
12
2
93
91
1


1
13
1
191
196
3
1
−10
2
208
209
1
−3
0
2
456
444
5
3
5
2
247
244
3
−3
12
2
128
127
1


2
13
1
201
205
3
2
−10
2
56
51
1
−2
0
2
332
332
3
4
5
2
172
181
1
−2
12
2
115
117
2


3
13
1
82
85
1
3
−10
2
91
91
1
−1
0
2
967
976
10
5
5
2
76
68
1
−1
12
2
85
79
2


4
13
1
26
27
1
4
−10
2
63
64
1
0
0
2
198
202
2
6
5
2
84
101
1
1
12
2
116
113
2


5
13
1
20
20
1
5
−10
2
93
93
1
1
0
2
282
287
3
7
5
2
0
4
1
2
12
2
21
27
1


−4
14
1
71
72
1
6
−10
2
73
75
1
2
0
2
33
49
1
−8
6
2
84
85
1
3
12
2
93
100
1


4
12
2
70
67
1
−5
−10
3
147
150
2
−2
−2
3
513
511
5
−3
4
3
169
164
2
−2
10
3
79
78
1


5
12
2
53
52
1
−4
−10
3
50
55
1
−1
−2
3
621
628
6
−2
4
3
62
70
1
−1
10
3
272
279
4


−5
13
2
25
22
1
−3
−10
3
183
194
1
0
−2
3
994
1008
9
−1
4
3
130
134
1
0
10
3
122
135
2


−4
13
2
175
174
2
−2
−10
3
80
79
1
1
−2
3
465
462
4
0
4
3
176
179
3
1
10
3
138
132
2


−3
13
2
86
89
1
−1
−10
3
271
279
1
2
−2
3
160
168
1
1
4
3
196
194
2
2
10
3
32
29
1


−2
13
2
236
236
4
0
−10
3
126
135
1
7
−2
3
92
97
1
2
4
3
328
305
5
3
10
3
222
221
2


−1
13
2
94
92
2
1
−10
3
138
132
1
−8
−1
3
10
17
1
3
4
3
55
53
1
4
10
3
69
65
1


1
13
2
80
89
2
2
−10
3
29
29
1
−7
−1
3
16
9
1
4
4
3
100
109
1
5
10
3
52
53
1


2
13
2
127
131
1
3
−10
3
222
221
4
−6
−1
3
67
65
1
5
4
3
185
186
1
−6
11
3
69
68
1


3
13
2
114
111
1
4
−10
3
68
64
1
−4
−1
3
327
314
6
6
4
3
59
58
1
−5
11
3
111
114
2


4
13
2
118
111
1
5
−10
3
54
52
1
−3
−1
3
60
62
1
7
4
3
37
33
1
−4
11
3
99
106
1


5
13
2
76
75
1
6
−10
3
27
24
1
−2
−1
3
475
474
5
−8
5
3
22
24
1
−3
11
3
251
251
3


−5
14
2
65
62
1
−7
−9
3
44
45
1
−1
−1
3
219
224
2
−7
5
3
35
28
1
−2
11
3
140
128
2


−4
14
2
117
114
1
−6
−9
3
132
130
2
0
−1
3
807
818
8
−6
5
3
109
104
1
−1
11
3
93
94
2


−3
14
2
51
50
1
−5
−9
3
106
104
2
1
−1
3
206
200
2
−5
5
3
207
205
1
1
11
3
239
244
3


1
14
2
112
116
2
−4
−9
3
95
97
1
2
−1
3
103
104
1
−4
5
3
75
77
1
2
11
3
155
162
2


2
14
2
44
47
1
−3
−9
3
111
103
1
3
−1
3
33
40
1
−3
5
3
200
197
3
3
11
3
81
82
1


3
14
2
24
23
1
−2
−9
3
103
104
1
6
−1
3
118
120
2
−2
5
3
117
111
3
4
11
3
106
104
1


4
14
2
45
44
1
−1
−9
3
153
158
1
7
−1
3
72
74
1
−1
5
3
162
158
3
5
11
3
92
88
1


−4
15
2
26
26
1
0
−9
3
185
193
1
−8
0
3
67
61
1
0
5
3
339
325
5
−6
12
3
52
48
1


−3
15
2
157
147
2
1
−9
3
177
187
1
−7
0
3
17
17
1
1
5
3
703
701
12
−5
12
3
30
27
1


−2
15
2
74
71
1
2
−9
3
125
114
1
−6
0
3
87
91
1
2
5
3
251
257
4
−4
12
3
119
130
1


1
15
2
56
53
1
3
−9
3
75
68
1
−5
0
3
68
76
1
3
5
3
81
86
1
−3
12
3
15
7
2


2
15
2
26
27
1
4
−9
3
182
179
3
−4
0
3
82
68
1
4
5
3
59
59
1
−2
12
3
162
163
3


3
15
2
95
97
1
5
−9
3
123
115
2
−3
0
3
510
487
6
5
5
3
104
106
1
−1
12
3
128
129
2


−3
16
2
3
2
3
6
−9
3
29
28
1
−2
0
3
41
45
1
5
5
3
102
112
1
1
12
3
93
96
2


−2
16
2
100
95
1
−7
−8
3
49
46
1
−1
0
3
962
987
10
7
5
3
40
41
1
2
12
3
172
173
2


2
16
2
27
30
1
−6
−8
3
79
82
1
0
0
3
544
559
7
−8
6
3
34
34
1
3
12
3
71
77
1


−2
−16
3
106
98
2
−5
−8
3
34
32
1
1
0
3
293
301
3
−7
6
3
28
27
1
4
12
3
39
40
1


−1
−16
3
68
65
1
−4
−8
3
151
152
2
2
0
3
386
375
4
−6
6
3
250
250
3
5
12
3
49
49
1


0
−16
3
57
54
1
−3
−8
3
68
72
1
3
0
3
84
85
1
−5
6
3
217
224
1
−5
13
3
101
99
1


1
−16
3
38
35
1
−2
−8
3
172
177
1
5
0
3
179
177
3
−4
6
3
182
188
1
−4
13
3
119
117
2


2
−16
3
43
45
1
−1
−8
3
79
80
1
6
0
3
133
128
2
−3
6
3
37
32
3
−3
13
3
159
157
2


−4
−15
3
124
123
2
0
−8
3
109
99
1
7
0
3
148
158
2
−2
6
3
116
110
3
−2
13
3
146
153
3


−3
−15
3
102
101
1
1
−8
3
181
172
1
−8
1
3
13
18
1
−1
6
3
7
8
6
1
13
3
125
127
2


−2
−15
3
97
95
1
2
−8
3
77
77
1
−7
1
3
14
9
1
0
6
3
311
307
5
2
13
3
134
135
1


−1
−15
3
75
72
1
3
−8
3
18
16
1
−6
1
3
71
66
1
1
6
3
279
255
7
3
13
3
98
96
1


0
−15
3
72
73
1
4
−8
3
130
141
2
−5
1
3
73
76
1
2
6
3
381
377
9
4
13
3
64
61
1


1
−15
3
68
67
1
5
−8
3
138
140
2
−4
1
3
333
314
3
3
6
3
51
47
1
−4
14
3
159
149
2


2
−15
3
47
47
1
6
−8
3
84
82
1
−3
1
3
60
61
1
4
6
3
178
181
1
−3
14
3
51
47
1


3
−15
3
52
53
1
−7
−7
3
85
88
1
−2
1
3
478
474
5
5
6
3
224
219
2
−2
14
3
62
59
1


−5
−14
3
57
57
1
−6
−7
3
110
109
2
−1
1
3
222
224
2
6
6
3
84
83
1
1
14
3
9
12
6


−4
−14
3
154
149
2
−5
−7
3
99
99
2
0
1
3
798
818
10
7
6
3
41
39
1
2
14
3
18
18
1


−3
−14
3
49
47
1
−4
−7
3
76
80
1
1
1
3
201
198
2
−7
7
3
87
88
1
3
14
3
54
54
1


−2
−14
3
61
59
1
−3
−7
3
138
141
1
2
1
3
101
104
1
−6
7
3
115
110
1
4
14
3
70
65
1


−1
−14
3
131
131
1
−2
−7
3
235
237
3
3
1
3
33
41
1
−5
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3
101
100
1
−4
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3
124
123
2


0
−14
3
42
36
1
−1
−7
3
57
67
1
4
1
3
143
141
1
−4
7
3
76
80
1
−3
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3
103
101
1


1
−14
3
9
12
1
0
−7
3
47
42
1
5
1
3
68
65
1
−3
7
3
136
141
1
−2
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3
96
96
2


2
−14
3
14
18
1
1
−7
3
109
98
1
6
1
3
120
120
2
−2
7
3
236
236
6
1
15
3
67
67
1


3
−14
3
52
53
1
2
−7
3
122
112
1
7
1
3
71
73
1
−1
7
3
57
67
1
2
15
3
45
48
1


4
−14
3
68
65
1
3
−7
3
203
212
3
−8
2
3
17
26
1
0
7
3
48
43
2
3
15
3
53
53
1


−5
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97
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2
4
−7
3
102
104
1
−7
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3
68
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1
1
7
3
106
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3
−2
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3
102
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1


−4
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116
117
1
5
−7
3
176
176
3
−6
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3
31
27
1
2
7
3
122
112
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2
16
3
47
46
1


−3
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156
157
1
6
−7
3
81
84
1
−5
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3
166
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1
3
7
3
198
211
1
−2
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48
45
1


−2
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145
153
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−7
−6
3
25
27
1
−4
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3
61
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1
4
7
3
102
103
1
−1
−16
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3
3
2


−1
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3
241
249
2
−6
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3
245
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4
−3
2
3
261
261
3
5
7
3
174
176
1
0
−16
4
94
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1


0
−13
3
169
172
1
−5
−6
3
216
224
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−2
2
3
511
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6
7
3
83
84
1
1
−16
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28
29
1


1
−13
3
123
127
1
−4
−6
3
181
188
3
−1
2
3
616
629
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7
7
3
60
61
1
−3
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4
29
29
1


2
−13
3
134
136
1
−3
−6
3
37
32
1
0
2
3
988
1007
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−6
8
3
78
82
1
−2
−15
4
97
95
1


3
−13
3
97
96
1
−2
−6
3
123
111
1
1
2
3
462
462
4
−5
8
3
36
32
1
−1
−15
4
109
107
1


4
−13
3
62
61
1
−1
−6
3
13
7
2
2
2
3
163
168
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−4
8
3
149
152
1
0
−15
4
51
53
1


5
−13
3
42
38
1
0
−6
3
300
306
4
3
2
3
265
255
3
−3
8
3
68
72
1
1
−15
4
47
45
1


−6
−12
3
54
49
1
1
−6
3
284
255
3
4
2
3
74
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1
−2
8
3
174
177
2
2
−15
4
74
76
1


−5
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3
28
27
1
2
−6
3
385
377
4
5
2
3
162
157
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−1
8
3
83
79
2
−4
−14
4
59
60
1


−4
−12
3
118
128
2
3
−6
3
49
47
1
6
2
3
75
72
1
0
8
3
109
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−3
−14
4
102
101
1


−3
−12
3
13
6
1
−3
−5
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202
197
2
7
2
3
95
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1
1
8
3
182
172
2
−2
−14
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26
25
1


−2
−12
3
162
163
1
−2
−5
3
124
110
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−8
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3
80
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1
2
8
3
77
77
1
−1
−14
4
35
39
1


−1
−12
3
128
130
1
−1
−5
3
159
158
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−7
3
3
162
168
2
3
8
3
14
16
1
0
−14
4
99
101
1


0
−12
3
68
67
1
0
−5
3
331
326
3
−6
3
3
170
165
3
4
8
3
131
142
1
1
−14
4
42
40
1


1
−12
3
93
96
1
1
−5
3
718
700
7
−5
3
3
68
60
1
5
8
3
133
140
1
2
−14
4
67
67
1


2
−12
3
172
174
1
2
−5
3
257
257
2
−4
3
3
76
78
1
6
8
3
83
82
1
3
−14
4
53
54
1


3
−12
3
71
77
1
−3
−4
3
170
164
1
−3
3
3
324
298
4
−6
9
3
131
130
1
4
−14
4
61
62
1


4
−12
3
39
41
1
−2
−4
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66
69
1
−2
3
3
100
89
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−5
9
3
102
104
1
−5
−13
4
43
43
1


5
−12
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50
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1
−1
−4
3
131
134
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−1
3
3
400
401
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−4
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3
93
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1
−4
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4
92
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1


−6
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70
69
1
0
−4
3
173
179
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0
3
3
654
670
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−3
9
3
108
103
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−3
−13
4
123
127
1


−5
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3
113
115
2
1
−4
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198
194
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1
3
3
379
395
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−2
9
3
107
105
1
−2
−13
4
118
113
1


−4
−11
3
99
106
2
2
−4
3
327
304
3
2
3
3
277
272
3
−1
9
3
148
158
2
−1
−13
4
92
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1


−3
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3
252
251
2
−7
−3
3
167
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3
3
287
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0
9
3
187
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0
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212
225
1


−2
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137
128
1
−3
−3
3
321
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4
3
3
61
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1
1
9
3
176
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1
−13
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87
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1


−1
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3
93
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1
−2
−3
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103
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3
3
148
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2
9
3
126
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125
128
1


0
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240
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1
−1
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397
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3
6
3
3
118
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3
9
3
74
69
1
3
−13
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42
43
1


1
−11
3
240
246
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0
−3
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668
670
6
7
3
3
52
49
1
4
9
3
181
179
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4
−13
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100
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2


2
−11
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157
163
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1
−3
3
388
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−8
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3
36
39
1
5
9
3
118
115
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−6
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61
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1


3
−11
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80
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2
−3
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275
273
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−7
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3
60
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−6
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3
61
61
1
−5
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36
32
1


4
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105
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−8
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17
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1
−6
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3
134
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3
150
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65
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1


5
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−7
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3
67
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−5
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3
194
205
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−4
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3
48
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1
−3
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116
117
1


−6
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61
1
−3
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3
261
263
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−4
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3
287
288
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−3
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3
182
194
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−2
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70
72
1


−1
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61
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1
6
−6
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39
36
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0
4
41
41
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−1
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4
112
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−2
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4
119
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2


0
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62
1
−7
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39
43
1
−8
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4
39
38
1
0
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4
227
220
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1
13
4
87
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2


1
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119
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−6
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61
60
1
−7
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4
143
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1
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125
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1


2
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50
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−5
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216
214
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−6
1
4
54
54
1
2
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4
37
33
1
3
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4
45
43
1


3
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20
20
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−4
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57
54
1
−5
1
4
152
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1
3
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4
141
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4
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4
100
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1


4
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23
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135
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−4
1
4
442
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4
6
4
229
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4
61
60
1


5
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51
1
−2
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419
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−3
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4
83
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4
63
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4
103
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1


−6
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90
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1
−1
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294
302
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−2
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4
379
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6
6
4
40
35
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−2
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4
29
25
2


−5
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190
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0
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267
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−1
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4
376
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7
6
4
96
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1
14
4
42
40
1


−4
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152
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1
−5
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693
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0
1
4
260
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−7
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4
14
13
1
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14
4
67
67
1


−3
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117
114
1
2
−5
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276
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1
1
4
124
115
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−6
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4
48
46
1
3
14
4
55
54
1


−2
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306
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3
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255
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2
1
4
200
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−5
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4
182
184
1
4
14
4
67
62
1


−1
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141
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1
4
−5
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261
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3
1
4
83
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1
−4
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4
71
70
1
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4
103
103
2


0
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1
5
−5
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77
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1
4
1
4
134
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−3
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4
52
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1
−3
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4
28
28
1


1
−11
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70
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1
6
−5
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58
53
1
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1
4
128
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−2
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4
231
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1
15
4
47
45
1


2
−11
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79
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1
−8
−4
4
97
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1
6
1
4
135
130
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−1
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4
73
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2
15
4
75
76
1


3
−11
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57
70
1
−7
−4
4
37
33
1
7
1
4
54
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1
0
7
4
192
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3
3
15
4
30
30
1


4
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1
−6
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171
172
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−8
2
4
10
10
2
1
7
4
30
21
3
−2
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4
52
45
1


5
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90
89
1
−5
−4
4
154
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−7
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4
101
100
1
2
7
4
149
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1
16
4
28
29
1


−6
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92
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1
−4
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220
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−6
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4
130
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3
7
4
121
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42
41
1


−5
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−3
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107
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4
121
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4
7
4
148
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26
25
1


−4
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−2
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188
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−4
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4
231
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7
4
170
163
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0
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24
27
1


−3
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53
1
−1
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125
128
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−3
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4
256
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6
7
4
18
13
1
1
−16
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102
104
2


−2
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34
28
1
0
−4
4
384
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−2
2
4
80
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1
7
7
4
25
32
1
−3
−15
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26
26
1


−1
−10
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140
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1
−4
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199
183
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−1
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4
203
205
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−7
8
4
28
29
1
−2
−15
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194
186
2


0
−10
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234
232
1
2
−4
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198
192
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0
2
4
563
566
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−6
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4
127
131
1
−1
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59
58
1


1
−10
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1
6
−4
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90
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1
2
4
107
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−5
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4
150
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0
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82
82
1


2
−10
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97
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1
−8
−3
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33
27
1
2
2
4
170
169
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−4
8
4
103
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1
−15
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99
91
1


3
−10
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116
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−7
−3
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60
58
1
3
2
4
144
147
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−3
8
4
91
89
1
2
−15
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70
70
1


4
−10
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123
121
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−6
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210
215
3
4
2
4
64
66
1
−2
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4
62
67
1
−4
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114
112
1


5
−10
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29
32
1
−5
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80
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1
5
2
4
38
33
1
−1
8
4
68
70
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−3
−14
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127
130
1


6
−10
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30
31
1
−4
−3
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107
102
1
6
2
4
195
195
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0
8
4
155
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−2
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188
191
1


−7
−9
4
51
48
1
−3
−3
4
145
142
1
7
2
4
30
23
1
1
8
4
130
142
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−1
−14
5
122
120
1


−6
−9
4
80
77
1
−2
−3
4
209
214
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−8
3
4
34
27
1
2
8
4
115
113
1
0
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57
59
1


−5
−9
4
94
96
1
−1
−3
4
189
191
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−7
3
4
56
57
1
3
8
4
124
118
1
1
−14
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10
9
1


−4
−9
4
18
19
1
0
−3
4
304
309
2
−6
3
4
215
214
3
4
8
4
212
216
2
2
−14
5
68
67
1


−3
−9
4
137
136
1
1
−3
4
176
180
1
−5
3
4
80
77
1
5
8
4
104
114
1
3
−14
5
59
61
1


−2
−9
4
154
156
1
2
−3
4
281
289
3
−4
3
4
106
102
1
6
8
4
137
138
2
−5
−13
5
23
23
1


−1
−9
4
156
159
1
3
−3
4
107
99
1
−3
3
4
143
142
2
−6
9
4
77
78
1
−4
−13
5
115
116
1


0
−9
4
179
182
1
6
−3
4
61
58
1
−2
3
4
208
214
2
−5
9
4
95
97
1
−3
−13
5
102
99
1


1
−9
4
218
214
1
7
−3
4
68
65
1
−1
3
4
184
191
2
−4
9
4
18
19
1
−2
−13
5
126
125
1


2
−9
4
68
65
1
−8
−2
4
13
10
1
0
3
4
308
311
3
−3
9
4
137
136
1
−1
−13
5
99
107
1


3
−9
4
41
45
1
−7
−2
4
99
99
1
1
3
4
174
180
2
−2
9
4
153
157
2
0
−13
5
114
118
1


4
−9
4
78
78
1
−6
−2
4
126
130
2
2
3
4
285
289
4
−1
9
4
152
158
2
1
−13
5
65
69
1


5
−9
4
125
122
2
−5
−2
4
120
129
1
3
3
4
108
99
1
0
9
4
173
183
3
2
−13
5
37
38
1


6
−9
4
89
92
1
−4
−2
4
231
231
3
4
3
4
73
77
1
1
9
4
218
213
3
3
−13
5
48
55
1


−7
−8
4
29
29
1
−3
−2
4
256
245
2
5
3
4
105
109
1
2
9
4
68
64
1
4
−13
5
32
37
1


−6
−8
4
129
131
2
−2
−2
4
79
78
1
6
3
4
59
58
1
3
9
4
42
45
1
−6
−12
5
52
47
1


−5
−8
4
151
152
2
−1
−2
4
202
204
1
7
3
4
71
65
1
4
9
4
78
77
1
−5
−12
5
91
94
1


−4
−8
4
103
99
2
0
−2
4
559
566
5
−8
4
4
98
96
1
5
9
4
124
122
1
−4
−12
5
47
48
1


−3
−8
4
94
89
1
1
−2
4
109
114
1
−7
4
4
36
33
1
−6
10
4
93
96
1
−3
−12
5
69
70
1


−2
−8
4
64
67
1
2
−2
4
167
169
1
−6
4
4
172
172
2
−5
10
4
100
100
1
−2
−12
5
75
72
1


−1
−8
4
68
70
1
3
−2
4
144
147
2
−5
4
4
154
162
1
−4
10
4
101
106
1
−1
−12
5
226
230
1


0
−8
4
153
160
1
5
−2
4
39
33
1
−4
4
4
215
206
1
−3
10
4
57
53
1
0
−12
5
155
146
1


1
−8
4
130
141
1
6
−2
4
197
195
3
−3
4
4
105
104
2
−2
10
4
36
28
1
1
−12
5
64
61
1


2
−8
4
115
113
1
7
−2
4
30
23
1
−2
4
4
186
191
3
−1
10
4
138
146
2
2
−12
5
163
164
1


3
−8
4
127
119
2
−8
−1
4
40
38
1
−1
4
4
129
127
2
0
10
4
235
232
3
3
−12
5
25
29
1


4
−8
4
211
216
3
−7
−1
4
141
143
2
0
4
4
390
374
6
1
10
4
106
104
2
4
−12
5
46
43
1


5
−8
4
105
113
2
−6
−1
4
54
54
1
1
4
4
196
181
3
2
10
4
96
93
1
−6
−11
5
30
29
1


6
−8
4
140
139
2
−5
−1
4
151
147
2
2
4
4
198
191
3
3
10
4
119
123
1
−5
−11
5
52
57
1


−7
−7
4
13
13
1
−4
−1
4
440
419
5
3
4
4
70
71
1
4
10
4
123
121
1
−4
−11
5
55
54
1


−6
−7
4
49
45
1
−3
−1
4
85
83
1
4
4
4
53
51
1
5
10
4
30
32
1
−3
−11
5
163
156
1


−5
−7
4
185
184
3
−2
−1
4
375
376
4
5
4
4
170
167
1
−6
11
4
87
86
1
−2
−11
5
266
268
2


−4
−7
4
72
69
1
−1
−1
4
374
382
4
6
4
4
84
87
1
−5
11
4
190
190
2
−1
−11
5
304
302
2


−3
−7
4
52
48
1
0
−1
4
261
258
2
7
4
4
43
43
1
−4
11
4
160
164
2
0
−11
5
138
144
1


−2
−7
4
231
230
2
1
−1
4
123
115
1
−8
5
4
30
33
1
−3
11
4
117
114
2
1
−11
5
196
199
1


−1
−7
4
72
76
2
2
−1
4
201
199
2
−7
5
4
40
43
1
−2
11
4
304
307
4
2
−11
5
148
152
1


0
−7
4
189
186
3
3
−1
4
80
75
1
−6
5
4
63
61
1
−1
11
4
140
141
3
3
−11
5
95
99
1


1
−7
4
29
22
1
4
−1
4
132
130
2
−5
5
4
214
213
1
0
11
4
75
71
2
4
−11
5
60
62
1


2
−7
4
153
152
1
5
−1
4
125
130
2
−4
5
4
56
54
1
1
11
4
70
74
1
5
−11
5
93
94
1


3
−7
4
121
122
2
6
−1
4
133
130
2
−3
5
4
135
141
4
2
11
4
78
84
1
−6
−10
5
35
32
1


4
−7
4
149
142
2
7
−1
4
53
55
1
−2
5
4
397
407
10
3
11
4
62
70
1
−5
−10
5
202
209
3


5
−7
4
169
163
3
−8
0
4
28
28
1
−1
5
4
300
302
5
4
11
4
88
83
1
−4
−10
5
185
202
3


6
−7
4
20
12
1
−7
0
4
47
40
1
0
5
4
283
251
4
5
11
4
87
89
1
−3
−10
5
120
123
1


−7
−6
4
53
55
1
−6
0
4
131
132
2
2
5
4
280
266
7
−6
12
4
62
58
1
−2
−10
5
177
171
1


−6
−6
4
187
187
3
−5
0
4
320
331
5
3
5
4
262
257
2
−5
12
4
38
33
1
−1
−10
5
95
96
1


−5
−6
4
140
142
2
−4
0
4
35
22
1
4
5
4
272
254
2
−4
12
4
67
70
1
0
−10
5
97
95
1


−4
−6
4
216
208
3
−3
0
4
103
93
1
5
5
4
80
85
1
−3
12
4
115
117
1
1
−10
5
93
92
1


−3
−6
4
44
41
1
−2
0
4
91
99
1
6
5
4
57
52
1
−2
12
4
69
72
2
2
−10
5
75
77
1


−2
−6
4
110
102
1
−1
0
4
622
630
8
7
5
4
47
44
1
1
12
4
121
120
2
3
−10
5
56
60
1


−1
−6
4
105
102
1
0
0
4
870
877
11
−8
6
4
71
71
1
2
12
4
52
50
1
4
−10
5
17
19
1


0
−6
4
223
219
3
1
0
4
48
52
1
−7
6
4
54
55
1
3
12
4
21
19
1
5
−10
5
61
58
1


1
−6
4
188
180
2
2
0
4
176
173
2
−6
6
4
188
187
3
4
12
4
24
23
1
−7
−9
5
18
21
1


2
−6
4
36
34
1
3
0
4
94
105
1
−5
6
4
136
142
1
5
12
4
55
51
1
−6
−9
5
92
93
1


3
−6
4
142
137
2
4
0
4
53
59
1
−4
6
4
210
208
1
−5
13
4
45
43
1
−5
−9
5
75
75
1


4
−6
4
231
232
4
5
0
4
66
69
1
−3
6
4
43
40
1
−4
13
4
96
95
1
−4
−9
5
141
146
1


5
−6
4
61
61
1
6
0
4
127
124
2
−2
6
4
111
103
3
−3
13
4
124
127
1
−3
−9
5
73
73
1


−2
−9
5
78
77
1
−3
−3
5
177
167
2
4
2
5
108
102
1
−1
8
5
12
11
3
−1
−13
6
122
125
1


−1
−9
5
162
149
1
−2
−3
5
183
175
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5
2
5
88
85
1
0
8
5
64
69
1
0
−13
6
79
85
1


0
−9
5
120
111
1
−1
−3
5
123
109
1
6
2
5
113
112
2
1
8
5
276
281
4
1
−13
6
127
129
1


1
−9
5
55
55
1
0
−3
5
104
104
1
7
2
5
38
37
1
2
8
5
188
178
2
2
−13
6
43
46
1


2
−9
5
154
149
1
1
−3
5
155
167
1
−8
3
5
39
38
1
3
8
5
212
222
2
3
−13
6
70
75
1


3
−9
5
25
22
1
2
−3
5
69
67
1
−7
3
5
67
79
1
4
8
5
61
64
1
−5
−12
6
65
61
1


4
−9
5
129
131
2
3
−3
5
67
79
1
−6
3
5
124
131
1
5
8
5
74
75
1
−4
−12
6
64
62
1


5
−9
5
51
51
1
4
−3
5
13
10
1
−5
3
5
177
184
1
6
8
5
51
50
1
−3
−12
6
146
146
1


6
−9
5
58
53
1
5
−3
5
88
86
1
−4
3
5
98
92
1
−6
9
5
92
92
1
−2
−12
6
100
95
1


−7
−8
5
94
91
1
6
−3
5
60
61
1
−3
3
5
176
166
2
−5
9
5
79
76
1
−1
−12
6
145
160
1


−6
−8
5
47
44
1
7
−3
5
50
49
1
−2
3
5
178
175
2
−4
9
5
143
146
1
0
−12
6
133
135
1


−5
−8
5
113
112
2
−8
−2
5
83
79
1
−1
3
5
124
110
2
−3
9
5
72
73
1
1
−12
6
102
98
1


−4
−8
5
53
58
1
−7
−2
5
114
119
2
0
3
5
105
104
2
−2
9
5
80
77
1
2
−12
6
56
56
1


−3
−8
5
156
174
1
−6
−2
5
178
177
3
1
3
5
157
168
2
−1
9
5
160
149
2
3
−12
6
54
50
1


−2
−8
5
86
97
1
−5
−2
5
130
131
2
2
3
5
70
67
1
0
9
5
118
111
2
4
−12
6
54
57
1


−1
−8
5
10
11
1
−4
−2
5
180
176
1
3
3
5
67
78
1
1
9
5
57
56
1
−6
−11
6
5
7
5


0
−8
5
64
69
1
−3
−2
5
165
155
1
4
3
5
12
9
1
2
9
5
151
148
2
−5
−11
6
60
58
1


1
−8
5
277
281
2
−2
−2
5
185
181
2
5
3
5
87
87
1
3
9
5
25
22
1
−4
−11
6
62
66
1


2
−8
5
188
177
1
−1
−2
5
246
242
2
6
3
5
59
61
1
4
9
5
129
131
1
−3
−11
6
18
15
1


3
−8
5
217
222
3
0
−2
5
325
312
4
7
3
5
50
48
1
5
9
5
50
51
1
−2
−11
6
71
74
1


4
−8
5
61
64
1
1
−2
5
219
204
2
−8
4
5
52
46
1
−6
10
5
34
32
1
−1
−11
6
204
211
1


5
−8
5
77
76
1
2
−2
5
227
229
2
−7
4
5
62
59
1
−5
10
5
210
209
2
0
−11
6
40
39
1


6
−8
5
51
49
1
3
−2
5
77
83
1
−6
4
5
95
93
1
−4
10
5
195
203
2
1
−11
6
140
138
1


−7
−7
5
57
56
1
4
−2
5
109
103
1
−5
4
5
234
237
1
−3
10
5
120
124
1
2
−11
6
106
117
1


−6
−7
5
107
109
1
5
−2
5
86
84
1
−4
4
5
143
147
1
−2
10
5
178
171
2
3
−11
6
104
108
2


−5
−7
5
43
44
1
6
−2
5
114
112
1
−3
4
5
229
227
6
−1
10
5
92
96
2
4
−11
6
90
87
1


−4
−7
5
163
165
1
7
−2
5
38
36
1
−2
4
5
70
73
1
0
10
5
96
95
1
5
−11
6
113
110
2


−3
−7
5
116
114
1
−8
−1
5
133
120
2
−1
4
5
218
210
3
1
10
5
95
92
1
−6
−10
6
27
23
1


−2
−7
5
66
72
1
−7
−1
5
18
19
1
0
4
5
275
252
4
2
10
5
75
78
1
−5
−10
6
162
171
2


−1
−7
5
97
88
1
−6
−1
5
169
166
3
1
4
5
496
501
9
3
10
5
56
60
1
−4
−10
6
225
234
2


0
−7
5
122
122
1
−5
−1
5
117
119
1
2
4
5
118
122
2
4
10
5
19
19
1
−3
−10
6
124
124
1


1
−7
5
273
279
1
−4
−1
5
315
317
3
3
4
5
55
58
1
5
10
5
60
57
1
−2
−10
6
162
163
1


2
−7
5
199
205
1
−3
−1
5
39
46
1
4
4
5
137
141
1
−6
11
5
30
29
1
−1
−10
6
164
161
1


3
−7
5
48
45
1
−2
−1
5
128
131
1
5
4
5
52
46
1
−5
11
5
52
56
1
0
−10
6
48
43
1


4
−7
5
54
51
1
−1
−1
5
211
223
2
6
4
5
74
76
1
−4
11
5
54
54
1
1
−10
6
96
97
1


5
−7
5
64
61
1
0
−1
5
83
72
1
7
4
5
60
58
1
−3
11
5
161
156
2
2
−10
6
32
33
1


6
−7
5
20
21
1
1
−1
5
190
188
2
−8
5
5
96
95
1
−2
11
5
272
268
5
3
−10
6
48
46
1


−7
−6
5
75
72
1
2
−1
5
253
249
3
−7
5
5
56
63
1
−1
11
5
300
302
6
4
−10
6
46
46
1


−6
−6
5
143
142
1
3
−1
5
90
90
1
−6
5
5
154
158
2
0
11
5
135
144
2
5
−10
6
77
82
1


−5
−6
5
202
199
3
4
−1
5
92
97
1
−5
5
5
227
233
1
1
11
5
196
199
3
−7
−9
6
53
56
1


−4
−6
5
23
21
1
5
−1
5
151
149
2
−4
5
5
190
191
1
2
11
5
149
153
2
−6
−9
6
67
65
1


−3
−6
5
126
127
1
6
−1
5
92
92
1
−3
5
5
232
248
3
3
11
5
90
99
1
−5
−9
6
57
65
1


−2
−6
5
132
130
1
7
−1
5
133
131
2
−2
5
5
114
121
3
4
11
5
63
62
1
−4
−9
6
136
141
1


−1
−6
5
294
309
5
−8
0
5
18
20
1
−1
5
5
332
325
5
5
11
5
90
94
1
−3
−9
6
117
116
1


0
−6
5
208
204
2
−7
0
5
61
71
1
0
5
5
73
67
1
−5
12
5
88
93
1
−2
−9
6
128
124
1


1
−6
5
360
355
4
−6
0
5
46
42
1
1
5
5
128
128
3
−4
12
5
48
48
1
−1
−9
6
137
136
1


2
−6
5
37
25
1
−5
0
5
36
37
1
2
5
5
364
356
5
−3
12
5
68
70
1
0
−9
6
224
219
1


3
−6
5
55
50
1
−4
0
5
500
502
5
3
5
5
77
61
1
−2
12
5
77
71
2
1
−9
6
170
174
1


4
−6
5
32
26
1
−3
0
5
196
207
2
4
5
5
193
198
1
0
12
5
151
147
3
2
−9
6
122
114
1


5
−6
5
137
134
2
−2
0
5
224
231
2
5
5
5
292
291
2
1
12
5
67
62
1
3
−9
6
159
171
3


6
−6
5
30
26
1
−1
0
5
170
178
2
6
5
5
142
139
2
2
12
5
161
164
2
4
−9
6
51
43
1


−8
−5
5
98
96
1
0
0
5
40
40
1
7
5
5
24
22
1
3
12
5
28
29
1
5
−9
6
69
69
1


−7
−5
5
56
63
1
1
0
5
57
50
1
−8
6
5
80
82
1
4
12
5
46
43
1
−7
−8
6
33
35
1


−6
−5
5
155
158
1
2
0
5
129
127
1
−7
6
5
74
73
1
−5
13
5
27
23
1
−6
−8
6
190
191
2


−5
−5
5
230
233
4
3
0
5
68
65
1
−6
6
5
144
143
1
−4
13
5
116
116
1
−5
−8
6
79
79
1


−4
−5
5
190
191
1
4
0
5
37
36
1
−5
6
5
201
199
2
−3
13
5
102
98
1
−4
−8
6
16
14
1


−3
−5
5
233
247
1
5
0
5
43
36
1
−4
6
5
25
22
1
−2
13
5
126
125
2
−3
−8
6
94
104
1


−2
−5
5
113
120
1
6
0
5
198
196
3
−3
6
5
124
127
1
1
13
5
64
69
1
−2
−8
6
24
30
1


−1
−5
5
314
324
4
7
0
5
74
71
1
−2
6
5
125
129
4
2
13
5
37
38
1
−1
−8
6
118
117
1


0
−5
5
70
66
1
−8
1
5
134
120
2
−1
6
5
303
309
5
3
13
5
51
55
1
0
−8
6
250
248
1


1
−5
5
133
128
1
−7
1
5
18
18
1
0
6
5
210
204
3
4
13
5
35
37
1
1
−8
6
65
66
1


2
−5
5
363
357
3
−6
1
5
170
167
3
1
6
5
360
354
9
−4
14
5
117
111
2
2
−8
6
240
233
2


3
−5
5
76
61
1
−5
1
5
115
119
1
2
6
5
37
25
1
−3
14
5
129
130
1
3
−8
6
69
60
1


4
−5
5
193
197
3
−4
1
5
309
317
2
3
6
5
54
50
1
−2
14
5
186
191
3
4
−8
6
171
169
3


5
−5
5
292
291
5
−3
1
5
38
46
1
4
6
5
32
27
1
1
14
5
10
9
4
5
−8
6
119
118
2


6
−5
5
140
139
2
−2
1
5
128
132
1
5
6
5
136
134
1
2
14
5
68
67
1
6
−8
6
54
53
1


−8
−4
5
53
46
1
−1
1
5
212
224
2
6
6
5
28
25
1
3
14
5
61
61
1
−7
−7
6
63
60
1


−7
−4
5
63
60
1
0
1
5
81
71
1
7
6
5
38
41
1
−3
15
5
28
26
1
−6
−7
6
104
103
1


−6
−4
5
94
93
1
1
1
5
192
188
2
−7
7
5
57
57
1
1
15
5
96
91
1
−5
−7
6
7
10
2


−5
−4
5
235
235
2
2
1
5
254
249
3
−6
7
5
104
110
1
2
15
5
69
70
1
−4
−7
6
70
70
1


−4
−4
5
145
147
1
3
1
5
90
90
1
−5
7
5
43
44
1
−3
−15
6
95
90
1
−3
−7
6
54
55
1


−3
−4
5
231
227
2
4
1
5
92
98
1
−4
7
5
163
165
1
−2
−15
6
89
86
1
−2
−7
6
93
90
1


−2
−4
5
70
73
1
5
1
5
152
149
2
−3
7
5
114
114
1
−1
−15
6
165
163
1
−1
−7
6
18
17
1


−1
−4
5
212
210
2
6
1
5
93
92
1
−2
7
5
70
72
1
0
−15
6
73
74
1
0
−7
6
219
210
1


0
−4
5
275
253
3
7
1
5
132
131
1
−1
7
5
100
89
2
1
−15
6
95
89
1
1
−7
6
121
121
1


1
−4
5
513
499
6
−8
2
5
82
79
1
0
7
5
123
122
2
2
−15
6
61
62
1
2
−7
6
92
100
1


2
−4
5
120
122
1
−7
2
5
109
119
2
1
7
5
280
280
4
−4
−14
6
92
95
1
3
−7
6
108
103
2


3
−4
5
54
57
1
−6
2
5
176
177
3
2
7
5
200
206
2
−3
−14
6
153
149
1
4
−7
6
233
238
4


4
−4
5
139
142
2
−5
2
5
131
131
1
3
7
5
46
45
1
−2
−14
6
140
136
1
5
−7
6
87
81
1


5
−4
5
52
46
1
−4
2
5
177
175
1
4
7
5
55
52
1
−1
−14
6
49
51
1
6
−7
6
60
60
1


6
−4
5
77
76
1
−3
2
5
161
156
2
5
7
5
62
61
1
0
−14
6
39
44
1
−7
−6
6
51
52
1


7
−4
5
62
59
1
−2
2
5
184
182
2
6
7
5
18
21
1
1
−14
6
38
38
1
−6
−6
6
63
60
1


−8
−3
5
37
37
1
−1
2
5
244
243
3
−6
8
5
45
44
1
2
−14
6
37
39
1
−5
−6
6
45
47
1


−7
−3
5
75
79
1
0
2
5
318
312
4
−5
8
5
111
112
1
−5
−13
6
53
54
1
−4
−6
6
105
106
1


−6
−3
5
128
131
2
1
2
5
218
203
3
−4
8
5
54
58
1
−4
−13
6
87
87
1
−3
−6
6
93
92
1


−5
−3
5
181
184
2
2
2
5
228
228
3
−3
8
5
159
175
1
−3
−13
6
53
55
1
−2
−6
6
177
173
1


−4
−3
5
101
93
1
3
2
5
77
83
1
−2
8
5
87
98
1
−2
−13
6
99
96
1
−1
−6
6
42
46
1


0
−6
6
101
105
1
−6
0
6
145
155
2
1
5
6
94
95
3
2
12
6
57
56
1
−5
−8
7
186
208
2


1
−6
6
217
220
1
−5
0
6
68
63
1
2
5
6
109
119
1
3
12
6
54
50
1
−4
−8
7
87
90
1


2
−6
6
124
128
1
−4
0
6
79
66
1
3
5
6
143
142
1
4
12
6
55
56
1
−3
−8
7
60
69
1


3
−6
6
149
142
1
−3
0
6
24
10
2
4
5
6
50
53
1
−5
13
6
54
55
1
−2
−8
7
224
237
1


4
−6
6
48
46
1
−2
0
6
159
167
2
5
5
6
169
162
1
−4
13
6
89
87
1
−1
−8
7
65
53
1


5
−6
6
70
65
1
−1
0
6
435
444
7
6
5
6
80
82
1
−3
13
6
51
55
1
0
−8
7
318
324
2


6
−6
6
76
76
1
0
0
6
265
270
3
−7
6
6
51
51
1
−2
13
6
98
96
2
1
−8
7
397
401
3


−8
−5
6
43
45
1
1
0
6
95
95
1
−6
6
6
62
60
1
0
13
6
79
85
2
2
−8
7
120
114
1


−7
−5
6
55
54
1
2
0
6
82
83
1
−5
6
6
48
47
1
1
13
6
127
130
2
3
−8
7
42
39
1


−6
−5
6
155
153
2
3
0
6
7
9
1
−4
6
6
105
106
1
2
13
6
44
46
1
4
−8
7
18
18
1


−5
−5
6
36
39
1
4
0
6
4
7
4
−3
6
6
94
92
1
3
13
6
71
75
1
5
−8
7
43
43
1


−4
−5
6
24
23
1
5
0
6
54
54
1
−2
6
6
178
174
2
−4
14
6
94
95
1
−7
−7
7
34
34
1


−3
−5
6
113
111
1
6
0
6
59
58
1
−1
6
6
43
46
2
−3
14
6
152
149
2
−6
−7
7
131
130
2


−2
−5
6
107
112
1
7
0
6
43
40
1
0
6
6
103
105
2
−2
14
6
136
136
2
−5
−7
7
58
62
1


−1
−5
6
317
317
5
−8
1
6
45
41
1
1
6
6
219
219
3
1
14
6
38
37
1
−4
−7
7
69
62
1


0
−5
6
332
330
5
−7
1
6
48
43
1
2
6
6
122
128
1
2
14
6
39
40
1
−3
−7
7
56
55
1


1
−5
6
93
96
1
−6
1
6
161
167
2
3
6
6
148
141
1
3
14
6
99
95
2
−2
−7
7
42
43
1


2
−5
6
109
119
1
−5
1
6
150
148
1
4
6
6
47
46
1
−3
15
6
93
90
1
−1
−7
7
67
71
1


3
−5
6
143
142
1
−4
1
6
114
113
1
5
6
6
71
65
1
1
15
6
90
89
1
0
−7
7
118
116
1


4
−5
6
52
53
1
−3
1
6
143
138
2
6
6
6
75
76
1
2
15
6
60
61
1
1
−7
7
65
62
1


5
−5
6
171
162
3
−2
1
6
85
81
1
−7
7
6
57
60
1
−2
−15
7
99
99
1
2
−7
7
147
148
1


6
−5
6
80
83
1
−1
1
6
543
538
9
−6
7
6
102
103
1
−1
−15
7
63
59
1
3
−7
7
71
72
1


−8
−4
6
37
33
1
0
1
6
247
262
3
−5
7
6
7
10
3
0
−15
7
108
110
1
4
−7
7
17
11
1


−7
−4
6
74
78
1
1
1
6
89
82
1
−4
7
6
71
70
1
1
−15
7
77
76
1
5
−7
7
83
81
1


−6
−4
6
50
47
1
2
1
6
182
176
2
−3
7
6
55
54
1
−4
−14
7
62
61
1
6
−7
7
45
41
1


−5
−4
6
46
46
1
3
1
6
48
47
1
−2
7
6
93
91
1
−3
−14
7
39
38
1
−7
−6
7
23
23
1


−4
−4
6
106
107
1
4
1
6
78
85
1
−1
7
6
15
17
2
−2
−14
7
72
74
1
−6
−6
7
16
14
1


−3
−4
6
62
67
1
5
1
6
85
83
1
0
7
6
220
211
3
−1
−14
7
38
34
1
−5
−6
7
196
200
2


−2
−4
6
34
33
1
6
1
6
93
87
1
1
7
6
122
122
2
0
−14
7
59
58
1
−4
−6
7
162
163
1


−1
−4
6
227
221
4
7
1
6
27
29
1
2
7
6
92
100
1
1
−14
7
76
75
1
−3
−6
7
84
83
1


0
−4
6
295
279
4
−8
2
6
52
51
1
3
7
6
105
103
1
2
−14
7
97
96
1
−2
−6
7
114
112
1


1
−4
6
152
148
2
−7
2
6
32
35
1
4
7
6
228
239
2
−4
−13
7
55
53
1
−1
−6
7
44
38
1


2
−4
6
190
194
1
−6
2
6
210
211
2
5
7
6
84
81
1
−3
−13
7
98
97
1
0
−6
7
57
51
1


3
−4
6
51
53
1
−5
2
6
43
37
1
6
7
6
55
60
1
−2
−13
7
93
90
1
1
−6
7
59
57
1


4
−4
6
123
120
2
−4
2
6
146
153
1
−6
8
6
188
191
2
−1
−13
7
75
70
1
2
−6
7
198
199
1


5
−4
6
53
52
1
−3
2
6
139
135
2
−5
8
6
85
80
1
0
−13
7
53
48
1
3
−6
7
122
121
1


6
−4
6
118
112
2
−2
2
6
47
46
1
−4
8
6
21
15
1
1
−13
7
65
65
1
4
−6
7
68
66
1


−8
−3
6
56
47
1
−1
2
6
383
369
6
−3
8
6
96
104
1
2
−13
7
111
113
1
5
−6
7
66
65
1


−7
−3
6
83
82
1
0
2
6
476
464
8
−2
8
6
25
30
1
3
−13
7
90
92
1
6
−6
7
71
67
1


−6
−3
6
38
34
1
1
2
6
403
396
5
−1
8
6
117
116
1
−5
−12
7
23
22
1
−8
−5
7
56
52
1


−5
−3
6
105
106
1
2
2
6
145
145
2
0
8
6
252
248
3
−4
−12
7
132
132
1
−7
−5
7
7
9
6


−4
−3
6
111
116
1
3
2
6
53
53
1
1
8
6
63
65
1
−3
−12
7
29
22
1
−6
−5
7
47
44
1


−3
−3
6
140
140
2
4
2
6
161
158
1
2
8
6
239
232
2
−2
−12
7
98
94
1
−5
−5
7
113
115
1


−2
−3
6
36
35
1
5
2
6
146
151
2
3
8
6
68
60
1
−1
−12
7
87
89
1
−4
−5
7
91
95
1


−1
−3
6
196
199
3
6
2
6
41
42
1
4
8
6
169
169
2
0
−12
7
66
69
1
−3
−5
7
147
145
1


0
−3
6
353
336
4
7
2
6
64
68
1
5
8
6
118
118
2
1
−12
7
114
116
1
−2
−5
7
165
174
1


1
−3
6
147
144
2
−8
3
6
54
47
1
−6
9
6
68
65
1
2
−12
7
94
93
1
−1
−5
7
106
104
1


2
−3
6
99
102
1
−7
3
6
82
81
1
−5
9
6
60
65
1
3
−12
7
10
7
2
0
−5
7
211
208
2


3
−3
6
45
49
1
−6
3
6
36
34
1
−4
9
6
133
140
1
4
−12
7
53
54
1
1
−5
7
107
109
1


4
−3
6
24
25
1
−5
3
6
104
105
1
−3
9
6
119
116
1
−6
−11
7
18
16
1
2
−5
7
125
128
1


5
−3
6
138
143
2
−4
3
6
109
116
1
−2
9
6
127
123
2
−5
−11
7
118
117
1
3
−5
7
105
108
1


6
−3
6
141
135
2
−3
3
6
140
140
4
−1
9
6
134
136
2
−4
−11
7
115
114
1
4
−5
7
66
69
1


7
−3
6
19
14
1
−2
3
6
36
35
2
0
9
6
223
219
3
−3
−11
7
129
135
1
5
−5
7
83
83
1


−8
−2
6
55
51
1
−1
3
6
208
199
3
1
9
6
167
174
2
−2
−11
7
40
39
1
6
−5
7
15
17
1


−7
−2
6
32
35
1
0
3
6
357
335
6
2
9
6
123
115
1
−1
−11
7
46
46
1
−8
−4
7
18
14
1


−6
−2
6
212
211
3
1
3
6
144
145
4
3
9
6
173
171
2
0
−11
7
51
54
1
−7
−4
7
50
55
1


−5
−2
6
44
38
1
2
3
6
98
101
1
4
9
6
51
44
1
1
−11
7
136
144
1
−6
−4
7
149
151
2


−4
−2
6
147
153
1
3
3
6
46
49
1
5
9
6
70
70
1
2
−11
7
76
84
1
−5
−4
7
39
41
1


−3
−2
6
143
134
2
4
3
6
24
25
1
−6
10
6
25
23
1
3
−11
7
137
135
2
−4
−4
7
199
205
1


−2
−2
6
46
46
1
5
3
6
139
144
2
−5
10
6
165
172
2
4
−11
7
81
80
1
−3
−4
7
111
112
1


−1
−2
6
380
368
6
6
3
6
139
135
2
−4
10
6
231
233
3
−6
−10
7
112
115
2
−2
−4
7
158
160
3


0
−2
6
481
464
6
7
3
6
18
14
1
−3
10
6
125
124
1
−5
−10
7
82
80
1
−1
−4
7
392
399
6


1
−2
6
412
397
5
−8
4
6
37
33
1
−2
10
6
166
163
2
−4
−10
7
212
211
1
0
−4
7
174
173
3


2
−2
6
144
146
1
−7
4
6
70
78
1
−1
10
6
164
162
3
−3
−10
7
165
168
1
1
−4
7
361
375
2


3
−2
6
54
53
1
−6
4
6
50
47
1
0
10
6
46
43
1
−2
−10
7
91
85
1
2
−4
7
67
59
1


4
−2
6
163
157
2
−5
4
6
43
45
1
1
10
6
99
97
2
−1
−10
7
241
238
1
3
−4
7
37
37
1


5
−2
6
153
151
1
−4
4
6
104
107
1
2
10
6
35
34
1
0
−10
7
95
89
1
4
−4
7
101
93
1


6
−2
6
39
41
1
−3
4
6
60
66
1
3
10
6
46
46
1
1
−10
7
54
53
1
5
−4
7
176
173
3


7
−2
6
64
68
1
−2
4
6
33
33
2
4
10
6
47
45
1
2
−10
7
63
56
1
6
−4
7
100
99
1


−8
−1
6
45
41
1
−1
4
6
237
222
4
5
10
6
78
82
1
3
−10
7
39
37
1
−8
−3
7
25
21
1


−7
−1
6
51
44
1
0
4
6
300
278
5
−6
11
6
0
7
1
4
−10
7
43
38
1
−7
−3
7
49
56
1


−6
−1
6
167
166
2
1
4
6
154
148
4
−5
11
6
62
58
1
5
−10
7
76
72
1
−6
−3
7
45
39
1


−5
−1
6
150
149
1
2
4
6
191
195
1
−4
11
6
58
65
1
−7
−9
7
83
84
1
−5
−3
7
171
170
1


−4
−1
6
114
113
1
3
4
6
50
52
1
−3
11
6
20
15
1
−6
−9
7
47
50
1
−4
−3
7
145
143
1


−3
−1
6
145
138
2
4
4
6
122
120
1
−2
11
6
74
74
2
−5
−9
7
114
116
1
−3
−3
7
31
27
1


−2
−1
6
84
80
1
5
4
6
54
53
1
0
11
6
40
38
1
−4
−9
7
57
57
1
−2
−3
7
144
138
2


−1
−1
6
534
537
10
6
4
6
118
113
2
1
11
6
140
139
2
−3
−9
7
136
141
1
−1
−3
7
226
219
4


0
−1
6
249
262
3
7
4
6
46
42
1
2
11
6
106
117
1
−2
−9
7
135
140
1
0
−3
7
115
108
2


1
−1
6
89
81
1
−8
5
6
42
45
1
3
11
6
103
109
1
−1
−9
7
113
109
1
1
−3
7
299
296
4


2
−1
6
177
176
2
−7
5
6
56
55
1
4
11
6
91
87
1
0
−9
7
93
97
1
2
−3
7
19
10
1


3
−1
6
48
48
1
−6
5
6
151
154
1
5
11
6
113
110
2
1
−9
7
254
257
2
3
−3
7
106
109
1


4
−1
6
78
85
1
−5
5
6
39
39
1
−5
12
6
65
61
1
2
−9
7
179
174
1
4
−3
7
169
166
3


5
−1
6
89
84
1
−4
5
6
25
23
1
−4
12
6
66
62
1
3
−9
7
19
18
1
5
−3
7
81
84
1


6
−1
6
95
87
1
−3
5
6
115
111
2
−3
12
6
149
145
2
4
−9
7
44
41
1
6
−3
7
146
142
2


7
−1
6
27
29
1
−2
5
6
111
111
3
−2
12
6
100
95
2
5
−9
7
65
60
1
−8
−2
7
37
33
1


−8
0
6
45
50
1
−1
5
6
319
319
5
0
12
6
134
135
2
−7
−8
7
29
29
1
−7
−2
7
70
67
1


−7
0
6
34
28
1
0
5
6
329
329
5
1
12
6
101
97
2
−6
−8
7
39
45
1
−6
−2
7
162
161
2


−5
−2
7
213
210
1
−8
4
7
13
14
1
2
10
7
62
56
1
1
−9
8
183
188
1
6
−3
8
61
61
1


−4
−2
7
161
155
1
−7
4
7
49
54
1
3
10
7
42
38
1
2
−9
8
81
87
1
−8
−2
8
19
17
1


−3
−2
7
108
111
1
−6
4
7
149
152
1
4
10
7
42
37
1
3
−9
8
40
41
1
−7
−2
8
58
53
1


−2
−2
7
331
340
5
−5
4
7
39
41
1
5
10
7
75
72
1
4
−9
8
58
59
1
−6
−2
8
137
141
2


−1
−2
7
170
169
3
−4
4
7
202
206
1
−6
11
7
18
17
1
5
−9
8
58
63
1
−5
−2
8
242
244
2


0
−2
7
439
422
7
−3
4
7
108
112
1
−5
11
7
121
117
1
−7
−8
8
71
69
1
−4
−2
8
181
178
1


1
−2
7
210
203
2
−2
4
7
158
160
3
−4
11
7
115
114
1
−6
−8
8
18
17
1
−3
−2
8
198
204
1


2
−2
7
94
89
1
−1
4
7
386
399
6
−3
11
7
131
135
1
−5
−8
8
38
38
1
−2
−2
8
410
403
5


3
−2
7
60
58
1
0
4
7
174
173
3
−2
11
7
35
39
2
−4
−8
8
19
20
1
−1
−2
8
201
205
3


4
−2
7
189
191
3
1
4
7
365
375
5
0
11
7
51
54
1
−3
−8
8
11
13
1
0
−2
8
283
288
3


5
−2
7
219
220
3
2
4
7
70
59
1
1
11
7
140
143
2
−2
−8
8
188
191
1
1
−2
8
102
108
1


6
−2
7
152
151
2
3
4
7
38
37
1
2
11
7
77
84
1
−1
−8
8
168
171
1
2
−2
8
22
24
1


−8
−1
7
70
70
1
4
4
7
99
94
1
3
11
7
138
135
1
0
−8
8
160
163
1
3
−2
8
110
109
1


−7
−1
7
106
107
1
5
4
7
175
173
2
4
11
7
83
81
1
1
−8
8
310
308
2
4
−2
8
31
33
1


−6
−1
7
151
151
2
6
4
7
100
99
1
−5
12
7
24
22
1
2
−8
8
184
186
2
5
−2
8
133
139
2


−5
−1
7
38
34
1
−8
5
7
53
52
1
−4
12
7
136
132
1
3
−8
8
125
135
2
6
−2
8
153
148
2


−4
−1
7
189
195
1
−7
5
7
0
8
1
−3
12
7
26
22
1
4
−8
8
130
133
2
−8
−1
8
39
39
1


−3
−1
7
143
137
2
−6
5
7
49
44
1
−2
12
7
97
93
2
5
−8
8
32
31
1
−7
−1
8
84
83
1


−2
−1
7
133
124
2
−5
5
7
114
115
1
0
12
7
64
69
1
−7
−7
8
35
31
1
−6
−1
8
39
40
1


−1
−1
7
128
120
2
−4
5
7
90
95
1
1
12
7
114
115
1
−6
−7
8
147
143
2
−5
−1
8
78
78
1


0
−1
7
44
45
1
−3
5
7
148
145
1
2
12
7
96
92
1
−5
−7
8
21
19
1
−4
−1
8
121
131
1


1
−1
7
27
32
1
−2
5
7
165
174
2
3
12
7
4
7
3
−4
−7
8
69
66
1
−3
−1
8
24
21
1


2
−1
7
79
77
1
−1
5
7
109
104
2
4
12
7
55
54
1
−3
−7
8
27
33
1
−2
−1
8
129
137
2


3
−1
7
64
63
1
0
5
7
216
208
4
−4
13
7
57
53
1
−2
−7
8
68
65
1
−1
−1
8
87
87
2


4
−1
7
36
34
1
1
5
7
109
110
1
−3
13
7
96
96
1
−1
−7
8
45
49
1
0
−1
8
69
72
2


5
−1
7
51
47
1
2
5
7
126
128
1
−2
13
7
90
90
2
0
−7
8
124
127
1
1
−1
8
265
270
2


6
−1
7
153
147
2
3
5
7
105
109
1
0
13
7
49
49
1
1
−7
8
148
146
1
2
−1
8
106
113
1


−8
0
7
169
156
2
4
5
7
65
69
1
1
13
7
64
65
1
2
−7
8
78
74
1
3
−1
8
101
102
1


−7
0
7
116
119
2
5
5
7
82
83
1
2
13
7
116
114
1
3
−7
8
77
82
1
4
−1
8
36
37
1


−6
0
7
28
33
1
6
5
7
17
17
1
3
13
7
92
92
1
4
−7
8
63
71
1
5
−1
8
22
20
1


−5
0
7
52
56
1
−7
6
7
23
23
1
−4
14
7
62
61
1
5
−7
8
101
98
2
6
−1
8
49
47
1


−4
0
7
48
46
1
−6
6
7
16
14
1
−3
14
7
36
38
1
−7
−6
8
63
65
1
−8
0
8
21
11
1


−3
0
7
39
38
1
−5
6
7
200
200
2
−2
14
7
69
74
1
−6
−6
8
154
167
2
−7
0
8
102
93
1


−2
0
7
90
91
2
−4
6
7
162
163
1
1
14
7
75
75
1
−5
−6
8
60
62
1
−6
0
8
216
236
2


−1
0
7
84
99
2
−3
6
7
85
84
1
2
14
7
97
96
1
−4
−6
8
113
112
1
−5
0
8
225
234
1


0
0
7
67
71
1
−2
6
7
115
112
2
1
15
7
74
75
1
−3
−6
8
151
150
1
−4
0
8
87
85
1


1
0
7
229
238
3
−1
6
7
42
38
1
−1
−15
8
26
32
1
−2
−6
8
43
43
1
−3
0
8
14
11
1


2
0
7
281
295
2
0
6
7
58
51
1
−3
−14
8
53
56
1
−1
−6
8
88
85
1
−2
0
8
18
19
3


3
0
7
16
20
1
1
6
7
58
57
1
−2
−14
8
49
49
1
0
−6
8
95
100
1
−1
0
8
215
205
4


4
0
7
38
35
1
2
6
7
198
198
2
−1
−14
8
46
49
1
1
−6
8
75
73
1
0
0
8
49
26
2


5
0
7
53
54
1
3
6
7
120
120
1
0
−14
8
47
47
1
2
−6
8
256
253
2
1
0
8
31
31
1


6
0
7
187
191
3
4
6
7
68
66
1
1
−14
8
83
77
1
3
−6
8
100
98
2
2
0
8
19
19
1


−8
1
7
72
70
1
5
6
7
65
65
1
−4
−13
8
44
44
1
4
−6
8
105
108
2
3
0
8
202
204
1


−7
1
7
103
107
2
6
6
7
70
67
1
−3
−13
8
38
36
1
5
−6
8
9
10
2
4
0
8
47
48
1


−6
1
7
149
151
1
−6
7
7
128
130
1
−2
−13
8
124
120
1
−7
−5
8
14
16
1
5
0
8
39
36
1


−5
1
7
35
33
1
−5
7
7
62
61
1
−1
−13
8
23
23
1
−6
−5
8
32
34
1
6
0
8
27
28
1


−4
1
7
185
194
1
−4
7
7
69
62
1
0
−13
8
37
36
1
−5
−5
8
61
62
1
−8
1
8
39
37
1


−3
1
7
140
136
2
−3
7
7
58
56
1
1
−13
8
30
31
1
−4
−5
8
120
122
1
−7
1
8
85
83
1


−2
1
7
134
125
2
−2
7
7
43
42
1
2
−13
8
9
8
2
−3
−5
8
91
95
1
−6
1
8
39
40
1


−1
1
7
129
120
2
−1
7
7
68
71
1
−5
−12
8
32
29
1
−2
−5
8
103
108
1
−5
1
8
77
78
1


0
1
7
44
45
2
0
7
7
118
116
2
−4
−12
8
39
41
1
−1
−5
8
142
140
1
−4
1
8
122
130
1


1
1
7
27
32
1
1
7
7
66
62
1
−3
−12
8
98
94
1
0
−5
8
107
109
1
−3
1
8
23
21
1


2
1
7
79
78
1
2
7
7
148
149
1
−2
−12
8
63
57
1
1
−5
8
107
114
1
−2
1
8
133
137
2


3
1
7
64
64
1
3
7
7
73
72
1
−1
−12
8
77
81
1
2
−5
8
134
136
1
−1
1
8
86
88
2


4
1
7
35
34
1
4
7
7
15
10
1
0
−12
8
18
19
1
3
−5
8
66
70
1
0
1
8
70
73
2


5
1
7
50
47
1
5
7
7
81
82
1
1
−12
8
98
91
1
4
−5
8
33
35
1
1
1
8
267
271
3


6
1
7
149
147
2
−6
8
7
40
44
1
2
−12
8
44
47
1
5
−5
8
22
19
1
2
1
8
106
112
1


−8
2
7
38
34
1
−5
8
7
205
208
2
3
−12
8
71
74
1
6
−5
8
67
64
1
3
1
8
100
102
1


−7
2
7
67
67
1
−4
8
7
87
90
1
−6
−11
8
26
29
1
−8
−4
8
40
39
1
4
1
8
36
37
1


−6
2
7
161
161
1
−3
8
7
61
69
1
−5
−11
8
101
103
1
−7
−4
8
81
80
1
5
1
8
23
20
1


−5
2
7
212
210
1
−2
8
7
223
237
3
−4
−11
8
33
32
1
−6
−4
8
43
41
1
6
1
8
48
47
1


−4
2
7
160
155
1
−1
8
7
64
53
1
−3
−11
8
92
90
1
−5
−4
8
37
30
1
−8
2
8
16
16
1


−3
2
7
106
111
1
0
8
7
318
324
4
−2
−11
8
173
175
1
−4
−4
8
58
55
1
−7
2
8
58
53
1


−2
2
7
330
340
5
1
8
7
399
401
6
−1
−11
8
89
103
1
−3
−4
8
127
133
1
−6
2
8
146
142
1


−1
2
7
173
169
3
2
8
7
120
115
1
0
−11
8
133
132
1
−2
−4
8
17
20
1
−5
2
8
240
244
2


0
2
7
447
421
7
3
8
7
43
39
1
1
−11
8
55
60
1
−1
−4
8
70
80
1
−4
2
8
181
178
1


1
2
7
210
203
5
4
8
7
19
18
1
2
−11
8
79
79
1
0
−4
8
200
201
1
−3
2
8
198
204
1


2
2
7
93
89
1
5
8
7
42
43
1
3
−11
8
0
7
1
1
−4
8
64
62
1
−2
2
8
400
403
5


3
2
7
59
58
1
−6
9
7
47
50
1
4
−11
8
22
26
1
2
−4
8
150
147
1
−1
2
8
203
204
3


4
2
7
187
191
1
−5
9
7
118
117
1
−6
−10
8
44
45
1
3
−4
8
83
80
1
0
2
8
280
288
5


5
2
7
199
220
2
−4
9
7
57
58
1
−5
−10
8
70
73
1
4
−4
8
104
104
2
1
2
8
102
107
1


6
2
7
151
151
1
−3
9
7
137
141
1
−4
−10
8
66
69
1
5
−4
8
150
147
2
2
2
8
22
25
1


−8
3
7
26
21
1
−2
9
7
133
140
2
−3
−10
8
101
100
1
6
−4
8
116
109
2
3
2
8
109
109
1


−7
3
7
49
56
1
−1
9
7
111
110
2
−2
−10
8
53
58
1
−8
−3
8
29
28
1
4
2
8
33
32
1


−6
3
7
47
39
1
0
9
7
88
97
1
−1
−10
8
175
167
1
−7
−3
8
50
51
1
5
2
8
134
138
2


−5
3
7
172
171
1
1
9
7
253
257
3
0
−10
8
126
131
1
−6
−3
8
140
150
2
6
2
8
149
148
2


−4
3
7
145
143
1
2
9
7
179
174
2
1
−10
8
71
69
1
−5
−3
8
161
165
1
−8
3
8
29
28
1


−3
3
7
30
27
1
3
9
7
21
18
1
2
−10
8
46
50
1
−4
−3
8
145
157
1
−7
3
8
49
51
1


−2
3
7
145
138
2
4
9
7
44
42
1
3
−10
8
116
116
2
−3
−3
8
127
130
1
−6
3
8
152
149
1


−1
3
7
224
219
4
5
9
7
64
61
1
4
−10
8
28
30
1
−2
−3
8
116
115
1
−5
3
8
160
166
1


0
3
7
115
108
2
−6
10
7
113
115
1
−6
−9
8
35
35
1
−1
−3
8
323
314
4
−4
3
8
148
157
1


1
3
7
304
297
7
−5
10
7
80
79
1
−5
−9
8
158
156
2
0
−3
8
147
147
2
−3
3
8
126
130
1


2
3
7
15
11
1
−4
10
7
208
211
2
−4
−9
8
110
113
1
1
−3
8
150
148
1
−2
3
8
115
114
1


3
3
7
105
109
1
−3
10
7
164
168
2
−3
−9
8
71
75
1
2
−3
8
181
182
1
−1
3
8
321
314
5


4
3
7
172
166
1
−2
10
7
91
85
2
−2
−9
8
227
236
1
3
−3
8
76
78
1
0
3
8
148
146
2


5
3
7
75
85
1
0
10
7
94
89
2
−1
−9
8
23
22
1
4
−3
8
226
250
4
1
3
8
152
148
1


6
3
7
146
143
1
1
10
7
54
53
1
0
−9
8
97
98
1
5
−3
8
26
26
1
2
3
8
181
183
1


3
3
8
77
79
1
4
10
8
30
30
1
−7
−7
9
47
47
1
−1
−1
9
152
144
1
0
5
9
51
50
1


4
3
8
246
249
2
−5
11
8
102
103
1
−6
−7
9
47
50
1
0
−1
9
153
158
1
1
5
9
104
111
1


5
3
8
27
27
1
−4
11
8
33
32
1
−5
−7
9
103
104
2
1
−1
9
179
190
1
2
5
9
93
93
1


6
3
8
58
60
1
−3
11
8
94
90
2
−4
−7
9
106
105
1
2
−1
9
111
110
1
3
5
9
60
58
1


−8
4
8
39
38
1
−2
11
8
173
175
3
−3
−7
9
71
69
1
3
−1
9
56
55
1
4
5
9
126
130
1


−7
4
8
80
80
1
0
11
8
131
133
2
−2
−7
9
170
168
1
4
−1
9
78
81
1
5
5
9
53
52
1


−6
4
8
46
40
1
1
11
8
58
61
1
−1
−7
9
111
107
1
5
−1
9
81
80
1
−6
6
9
31
32
1


−5
4
8
36
29
1
2
11
8
79
79
1
0
−7
9
127
130
1
6
−1
9
99
100
1
−5
6
9
155
157
2


−4
4
8
58
55
1
3
11
8
2
7
2
1
−7
9
33
37
1
−8
0
9
129
128
2
−4
6
9
64
67
1


−3
4
8
127
133
1
4
11
8
21
26
1
2
−7
9
145
144
1
−7
0
9
80
86
1
−3
6
9
37
39
1


−2
4
8
17
19
2
−5
12
8
31
29
1
3
−7
9
123
127
2
−6
0
9
124
123
1
−2
6
9
28
33
1


−1
4
8
69
79
2
−4
12
8
37
40
1
4
−7
9
39
39
1
−5
0
9
151
158
1
−1
6
9
110
111
1


0
4
8
207
201
2
−3
12
8
95
93
1
5
−7
9
97
97
1
−4
0
9
132
141
1
0
6
9
219
217
3


1
4
8
64
62
1
−2
12
8
65
57
1
−7
−6
9
65
58
1
−3
0
9
16
18
1
1
6
9
89
93
1


2
4
8
151
147
1
0
12
8
19
19
2
−6
−6
9
37
32
1
−2
0
9
160
183
1
2
6
9
121
119
1


3
4
8
81
79
1
1
12
8
98
91
1
−5
−6
9
152
156
1
−1
0
9
27
25
1
3
6
9
68
66
1


4
4
8
106
104
1
2
12
8
44
46
1
−4
−6
9
65
67
1
0
0
9
321
321
3
4
6
9
61
61
1


5
4
8
148
147
2
3
12
8
72
73
1
−3
−6
9
37
39
1
1
0
9
60
65
1
−6
7
9
48
50
1


6
4
8
110
109
2
−4
13
8
44
43
1
−2
−6
9
30
34
1
2
0
9
171
181
1
−5
7
9
105
104
1


−7
5
8
7
16
7
−3
13
8
39
36
1
−1
−6
9
112
111
1
3
0
9
133
137
1
−4
7
9
104
105
1


−6
5
8
36
34
1
−2
13
8
117
120
2
0
−6
9
222
217
1
4
0
9
59
55
1
−3
7
9
72
70
2


−5
5
8
58
61
1
0
13
8
37
36
1
1
−6
9
89
93
1
5
0
9
219
217
4
−2
7
9
167
169
3


−4
5
8
122
121
1
1
13
8
30
30
1
2
−6
9
125
119
1
6
0
9
104
110
2
−1
7
9
109
107
1


−3
5
8
93
95
1
2
13
8
9
8
2
3
−6
9
65
66
1
−8
1
9
37
32
1
0
7
9
127
129
2


−2
5
8
104
108
1
−3
14
8
52
56
1
4
−6
9
60
62
1
−7
1
9
86
86
1
1
7
9
35
37
1


−1
5
8
139
140
1
1
14
8
80
77
1
5
−6
9
49
48
1
−6
1
9
127
126
1
2
7
9
135
144
2


0
5
8
108
109
1
−2
−14
9
26
27
1
−7
−5
9
44
41
1
−5
1
9
122
122
1
3
7
9
126
127
1


1
5
8
105
114
1
−1
−14
9
7
9
2
−6
−5
9
143
148
2
−4
1
9
47
48
1
4
7
9
38
39
1


2
5
8
137
136
1
0
−14
9
55
51
1
−5
−5
9
91
92
1
−3
1
9
76
77
1
−6
8
9
80
76
1


3
5
8
66
70
1
−4
−13
9
56
56
1
−4
−5
9
232
236
1
−2
1
9
185
186
2
−5
8
9
84
84
1


4
5
8
34
35
1
−3
−13
9
15
14
1
−3
−5
9
40
38
1
−1
1
9
152
144
1
−4
8
9
104
108
2


5
5
8
21
19
1
−2
−13
9
45
46
1
−2
−5
9
9
13
1
0
1
9
153
158
1
−3
8
9
88
88
1


6
5
8
64
64
1
−1
−13
9
26
26
1
−1
−5
9
120
115
1
1
1
9
179
190
1
−2
8
9
107
108
2


−7
6
8
58
66
1
0
−13
9
96
95
1
0
−5
9
50
49
1
2
1
9
111
110
1
−1
8
9
60
61
1


−6
6
8
160
166
1
1
−13
9
55
51
1
1
−5
9
104
112
1
3
1
9
57
55
1
0
8
9
115
121
2


−5
6
8
64
63
1
2
−13
9
36
36
1
2
−5
9
94
93
1
4
1
9
76
81
1
1
8
9
170
169
2


−4
6
8
116
113
1
−4
−12
9
71
71
1
3
−5
9
56
57
1
5
1
9
83
81
1
2
8
9
184
200
2


−3
6
8
151
150
2
−3
−12
9
102
101
1
4
−5
9
122
130
2
6
1
9
97
101
1
3
8
9
45
46
1


−2
6
8
45
43
1
−2
−12
9
68
67
1
5
−5
9
51
52
1
−8
2
9
19
20
1
4
8
9
62
64
1


−1
6
8
86
85
1
−1
−12
9
68
68
1
−7
−4
9
45
45
1
−7
2
9
64
66
1
−6
9
9
31
32
1


0
6
8
95
100
1
0
−12
9
35
33
1
−6
−4
9
35
37
1
−6
2
9
51
46
1
−5
9
9
24
23
1


1
6
8
76
73
1
1
−12
9
35
32
1
−5
−4
9
259
258
3
−5
2
9
70
73
1
−4
9
9
120
122
1


2
6
8
257
252
3
2
−12
9
70
64
1
−4
−4
9
50
53
1
−4
2
9
149
150
1
−3
9
9
166
171
2


3
6
8
100
98
1
−5
−11
9
40
43
1
−3
−4
9
4
8
4
−3
2
9
130
135
1
−2
9
9
122
120
2


4
6
8
107
108
1
−4
−11
9
22
22
1
−2
−4
9
88
85
1
−2
2
9
127
124
1
−1
9
9
313
322
6


5
6
8
2
10
2
−3
−11
9
56
55
1
−1
−4
9
131
130
1
−1
2
9
399
391
4
0
9
9
93
98
2


−6
7
8
147
143
1
−2
−11
9
16
21
1
0
−4
9
209
207
1
0
2
9
151
145
1
1
9
9
144
154
2


−5
7
8
20
20
1
−1
−11
9
84
84
1
1
−4
9
176
182
1
1
2
9
211
208
2
2
9
9
31
30
1


−4
7
8
66
65
1
0
−11
9
83
82
1
2
−4
9
154
156
1
2
2
9
228
231
1
3
9
9
51
49
1


−3
7
8
27
33
1
1
−11
9
99
101
1
3
−4
9
89
87
1
3
2
9
37
40
1
4
9
9
42
39
1


−2
7
8
67
65
1
2
−11
9
138
140
2
4
−4
9
69
77
1
4
2
9
58
55
1
−6
10
9
28
26
1


−1
7
8
44
49
1
3
−11
9
48
49
1
5
−4
9
123
122
2
5
2
9
80
79
1
−5
10
9
41
38
1


0
7
8
126
128
2
−6
−10
9
29
26
1
−8
−3
9
62
58
1
6
2
9
53
53
1
−4
10
9
122
122
1


1
7
8
148
146
1
−5
−10
9
41
38
1
−7
−3
9
66
58
1
−7
3
9
65
59
1
−3
10
9
42
46
1


2
7
8
77
75
1
−4
−10
9
120
122
1
−5
−3
9
227
224
2
−6
3
9
151
151
1
−2
10
9
66
72
2


3
7
8
85
82
1
−3
−10
9
44
45
1
−4
−3
9
154
160
1
−5
3
9
224
223
2
0
10
9
95
96
2


4
7
8
66
71
1
−2
−10
9
68
71
1
−3
−3
9
61
62
1
−4
3
9
156
160
1
1
10
9
100
107
1


−6
8
8
19
17
1
−1
−10
9
89
88
1
−2
−3
9
161
167
1
−3
3
9
62
63
1
2
10
9
91
86
1


−5
8
8
36
37
1
0
−10
9
96
96
1
−1
−3
9
32
37
1
−2
3
9
162
167
1
3
10
9
64
63
1


−4
8
8
18
20
1
1
−10
9
99
107
1
0
−3
9
69
78
1
−1
3
9
32
37
1
4
10
9
46
45
1


−3
8
8
8
13
5
2
−10
9
91
86
1
1
−3
9
175
181
1
0
3
9
68
77
1
−5
11
9
45
43
1


−2
8
8
188
190
3
3
−10
9
63
63
1
2
−3
9
141
148
1
1
3
9
176
181
2
−4
11
9
21
22
1


−1
8
8
166
171
2
4
−10
9
44
45
1
3
−3
9
47
45
1
2
3
9
143
149
1
−3
11
9
55
55
1


0
8
8
161
163
2
−6
−9
9
32
32
1
5
−3
9
165
161
3
3
3
9
49
46
1
−2
11
9
17
20
3


1
8
8
308
308
4
−5
−9
9
25
23
1
6
−3
9
76
74
1
4
3
9
52
45
1
0
11
9
81
83
2


2
8
8
180
186
2
−4
−9
9
123
122
1
−8
−2
9
19
19
1
5
3
9
165
161
3
1
11
9
98
101
1


3
8
8
135
135
1
−3
−9
9
166
171
1
−7
−2
9
64
66
1
6
3
9
75
74
1
2
11
9
143
140
1


4
8
8
128
133
1
−2
−9
9
122
120
1
−6
−2
9
48
46
1
−7
4
9
44
44
1
3
11
9
49
50
1


−6
9
8
36
35
1
−1
−9
9
319
322
2
−5
−2
9
70
73
1
−6
4
9
38
37
1
−4
12
9
71
70
1


−5
9
8
157
156
2
0
−9
9
95
99
1
−4
−2
9
148
150
1
−5
4
9
256
257
5
−3
12
9
103
100
1


−4
9
8
109
113
2
1
−9
9
144
155
1
−3
−2
9
129
135
1
−4
4
9
49
53
1
−2
12
9
65
66
2


−3
9
8
72
75
1
2
−9
9
30
29
1
−2
−2
9
128
124
1
−3
4
9
6
8
6
0
12
9
33
33
1


−2
9
8
232
235
4
3
−9
9
51
50
1
−1
−2
9
407
391
4
−2
4
9
85
85
1
1
12
9
35
32
1


0
9
8
98
99
2
4
−9
9
41
39
1
0
−2
9
152
145
1
−1
4
9
127
129
1
2
12
9
70
64
1


1
9
8
186
188
2
−7
−8
9
19
20
1
1
−2
9
210
207
1
0
4
9
214
208
3
−4
13
9
56
57
1


2
9
8
81
86
1
−6
−8
9
78
77
1
2
−2
9
228
231
1
1
4
9
178
183
2
−3
13
9
12
13
2


3
9
8
42
41
1
−5
−8
9
87
84
1
3
−2
9
39
40
1
2
4
9
155
155
1
−2
13
9
44
46
1


4
9
8
59
59
1
−4
−8
9
104
108
1
4
−2
9
52
55
1
3
4
9
90
87
1
1
13
9
55
51
1


−6
10
8
44
45
1
−3
−8
9
88
88
1
5
−2
9
80
78
1
4
4
9
76
77
1
2
13
9
37
36
1


−5
10
8
70
73
1
−2
−8
9
109
109
1
6
−2
9
54
53
1
5
4
9
125
123
2
−3
−13
10
27
27
1


−4
10
8
64
69
1
−1
−8
9
63
62
1
−8
−1
9
37
32
1
−7
5
9
42
41
1
−2
−13
10
32
30
1


−3
10
8
102
99
1
0
−8
9
113
120
1
−7
−1
9
86
86
1
−6
5
9
146
148
1
−1
−13
10
13
12
1


−2
10
8
56
58
2
1
−8
9
170
169
1
−6
−1
9
123
127
1
−5
5
9
90
92
2
0
−13
10
45
43
1


0
10
8
124
131
2
2
−8
9
199
199
2
−5
−1
9
123
121
1
−4
5
9
242
237
3
1
−13
10
38
33
1


1
10
8
72
69
1
3
−8
9
43
47
1
−4
−1
9
48
48
1
−3
5
9
40
38
1
−4
−12
10
47
47
1


2
10
8
44
50
1
4
−8
9
60
64
1
−3
−1
9
74
77
1
−2
5
9
6
13
5
−3
−12
10
75
77
1


3
10
8
115
116
1
5
−8
9
50
50
1
−2
−1
9
184
186
1
−1
5
9
118
116
1
−2
−12
10
31
30
1


−1
−12
10
33
33
1
2
−4
10
91
93
1
−2
3
10
123
121
1
−2
11
10
44
46
2
−3
−4
11
140
143
1


0
−12
10
42
44
1
3
−4
10
136
141
2
−1
3
10
19
16
1
0
11
10
100
103
2
−2
−4
11
69
65
1


1
−12
10
2
5
2
4
−4
10
69
68
1
0
3
10
189
186
2
1
11
10
116
120
1
−1
−4
11
52
47
1


−4
−11
10
63
61
1
5
−4
10
44
41
1
1
3
10
208
214
2
2
11
10
61
65
1
0
−4
11
32
25
1


−3
−11
10
73
75
1
−7
−3
10
36
36
1
2
3
10
152
153
1
3
11
10
30
25
1
1
−4
11
98
104
1


−2
−11
10
44
45
1
−6
−3
10
121
121
2
3
3
10
111
113
1
−4
12
10
45
46
1
2
−4
11
201
206
1


−1
−11
10
55
53
1
−5
−3
10
287
283
2
4
3
10
104
102
1
−3
12
10
76
77
1
3
−4
11
43
43
1


0
−11
10
104
103
1
−4
−3
10
221
223
2
5
3
10
79
80
1
−2
12
10
32
30
2
4
−4
11
18
20
1


1
−11
10
116
120
1
−3
−3
10
157
159
1
−6
4
10
27
26
1
0
12
10
42
44
1
−7
−3
11
92
93
1


−5
−10
10
77
79
1
−2
−3
10
122
121
1
−5
4
10
71
70
1
1
12
10
6
5
5
−6
−3
11
103
102
2


−4
−10
10
74
73
1
−1
−3
10
22
16
1
−4
4
10
37
38
1
2
12
10
40
40
1
−5
−3
11
150
148
1


−3
−10
10
55
59
1
0
−3
10
187
186
1
−3
4
10
89
85
1
−3
13
10
28
27
1
−4
−3
11
299
302
3


−2
−10
10
138
140
1
1
−3
10
207
215
1
−2
4
10
75
76
1
0
13
10
42
43
1
−3
−3
11
63
68
1


−1
−10
10
28
31
1
2
−3
10
152
153
1
−1
4
10
182
174
2
1
13
10
38
33
1
−2
−3
11
119
117
1


0
−10
10
153
150
1
3
−3
10
113
114
1
0
4
10
152
152
1
−3
−12
11
66
67
1
−1
−3
11
198
203
1


1
−10
10
136
136
1
4
−3
10
103
102
2
1
4
10
84
82
1
−2
−12
11
21
21
1
0
−3
11
138
130
1


2
−10
10
55
56
1
5
−3
10
78
80
1
2
4
10
90
93
1
−1
−12
11
31
29
1
1
−3
11
188
190
2


3
−10
10
13
16
1
−7
−2
10
61
62
1
3
4
10
138
141
1
0
−12
11
68
70
1
2
−3
11
66
72
1


−6
−9
10
49
48
1
−6
−2
10
76
77
1
4
4
10
69
69
1
1
−12
11
53
49
1
3
−3
11
139
141
1


−5
−9
10
97
99
1
−5
−2
10
158
161
1
5
4
10
42
41
1
−4
−11
11
73
71
1
4
−3
11
32
33
1


−4
−9
10
69
68
1
−4
−2
10
82
89
1
−6
5
10
13
9
1
−3
−11
11
53
54
1
5
−3
11
81
82
1


−3
−9
10
24
19
1
−3
−2
10
48
47
1
−5
5
10
41
38
1
−2
−11
11
65
63
1
−7
−2
11
37
34
1


−2
−9
10
119
124
1
−2
−2
10
40
40
1
−4
5
10
56
56
1
−1
−11
11
19
24
1
−6
−2
11
58
60
1


−1
−9
10
38
38
1
−1
−2
10
231
235
2
−3
5
10
104
107
1
0
−11
11
52
53
1
−5
−2
11
125
127
1


0
−9
10
216
218
2
0
−2
10
70
69
1
−2
5
10
151
151
2
1
−11
11
91
89
1
−4
−2
11
87
90
1


1
−9
10
86
90
1
1
−2
10
176
174
1
−1
5
10
71
72
1
−4
−10
11
28
30
1
−3
−2
11
25
26
1


2
−9
10
75
77
1
2
−2
10
187
187
1
0
5
10
78
83
1
−3
−10
11
128
127
1
−2
−2
11
145
151
1


3
−9
10
78
74
1
3
−2
10
140
137
1
1
5
10
80
80
1
−2
−10
11
74
71
1
−1
−2
11
76
77
1


4
−9
10
28
28
1
4
−2
10
71
73
1
2
5
10
100
105
1
−1
−10
11
68
63
1
0
−2
11
233
234
2


−6
−8
10
83
80
1
5
−2
10
71
73
1
3
5
10
16
19
1
0
−10
11
89
91
1
1
−2
11
116
119
1


−5
−8
10
60
60
1
−7
−1
10
84
83
1
4
5
10
91
92
1
1
−10
11
104
101
1
2
−2
11
56
60
1


−4
−8
10
93
93
1
−6
−1
10
110
112
1
−6
6
10
83
84
1
−4
−9
11
128
129
1
3
−2
11
67
65
1


−3
−8
10
19
17
1
−5
−1
10
19
19
1
−5
6
10
176
178
2
−3
−9
11
104
107
1
4
−2
11
123
125
2


−2
−8
10
50
53
1
−4
−1
10
70
68
1
−4
6
10
110
116
1
−2
−9
11
133
132
1
5
−2
11
71
72
1


−1
−8
10
87
87
1
−3
−1
10
97
97
1
−3
6
10
127
130
1
−1
−9
11
93
91
1
−7
−1
11
20
21
1


0
−8
10
157
157
1
−2
−1
10
66
65
1
−2
6
10
150
153
2
0
−9
11
49
48
1
−6
−1
11
139
136
1


1
−8
10
18
21
1
−1
−1
10
154
153
1
−1
6
10
62
65
1
1
−9
11
117
121
1
−5
−1
11
28
31
1


2
−8
10
62
63
1
0
−1
10
178
177
1
0
6
10
156
163
2
2
−9
11
82
83
1
−4
−1
11
135
130
1


3
−8
10
107
103
2
1
−1
10
43
43
1
1
6
10
117
123
1
3
−9
11
47
53
1
−3
−1
11
158
158
1


4
−8
10
43
44
1
2
−1
10
25
26
1
2
6
10
89
98
1
−6
−8
11
53
51
1
−2
−1
11
64
66
1


−7
−7
10
44
45
1
3
−1
10
93
91
1
3
6
10
71
70
1
−5
−8
11
49
50
1
−1
−1
11
10
8
2


−6
−7
10
60
58
1
4
−1
10
62
62
1
4
6
10
20
18
1
−4
−8
11
115
117
1
0
−1
11
111
113
1


−5
−7
10
127
130
1
5
−1
10
72
73
1
−6
7
10
60
58
1
−3
−8
11
69
70
1
1
−1
11
129
133
1


−4
−7
10
46
43
1
−7
0
10
84
82
1
−5
7
10
127
130
1
−2
−8
11
51
49
1
2
−1
11
100
104
1


−3
−7
10
8
6
3
−6
0
10
23
25
1
−4
7
10
45
43
1
−1
−8
11
117
121
1
3
−1
11
35
38
1


−2
−7
10
255
252
1
−5
0
10
23
17
1
−3
7
10
13
6
5
0
−8
11
125
126
1
4
−1
11
121
117
2


−1
−7
10
186
190
1
−4
0
10
128
134
1
−2
7
10
251
252
5
1
−8
11
91
93
1
5
−1
11
34
38
1


0
−7
10
128
132
1
−3
0
10
181
183
1
−1
7
10
186
190
2
2
−8
11
61
64
1
−7
0
11
35
34
1


1
−7
10
83
84
1
−2
0
10
44
49
1
0
7
10
132
132
2
3
−8
11
59
60
1
−6
0
11
133
129
1


2
−7
10
98
96
1
−1
0
10
214
206
2
1
7
10
84
84
1
−6
−7
11
69
66
1
−5
0
11
65
69
1


3
−7
10
48
47
1
0
0
10
159
168
1
2
7
10
91
95
1
−5
−7
11
35
35
1
−4
0
11
266
268
3


4
−7
10
49
52
1
1
0
10
101
96
1
3
7
10
50
47
1
−4
−7
11
126
128
1
−3
0
11
138
135
1


−7
−6
10
53
47
1
2
0
10
43
39
1
4
7
10
48
52
1
−3
−7
11
63
66
1
−2
0
11
73
74
1


−6
−6
10
82
84
1
3
0
10
126
131
1
−6
8
10
82
80
1
−2
−7
11
118
120
1
−1
0
11
12
10
2


−5
−6
10
180
178
1
4
0
10
202
199
3
−5
8
10
59
61
1
−1
−7
11
123
125
1
0
0
11
110
110
1


−4
−6
10
111
116
1
5
0
10
39
39
1
−4
8
10
93
93
1
0
−7
11
157
150
1
1
0
11
17
10
1


−3
−6
10
127
130
1
−7
1
10
84
82
1
−3
8
10
19
17
2
1
−7
11
36
41
1
2
0
11
76
78
1


−2
−6
10
155
154
1
−6
1
10
113
112
1
−2
8
10
51
53
2
2
−7
11
69
69
1
3
0
11
16
14
1


−1
−6
10
60
65
1
−5
1
10
24
20
1
−1
8
10
86
87
2
3
−7
11
29
27
1
4
0
11
8
5
3


0
−6
10
157
163
1
−4
1
10
71
67
1
0
8
10
156
157
3
4
−7
11
54
56
1
5
0
11
16
17
1


1
−6
10
117
123
1
−3
1
10
96
97
1
1
8
10
18
21
1
−6
−6
11
53
52
1
−7
1
11
20
21
1


2
−6
10
96
98
1
−2
1
10
66
65
1
2
8
10
57
63
1
−5
−6
11
105
97
1
−6
1
11
137
136
1


3
−6
10
72
71
1
−1
1
10
155
154
1
3
8
10
105
103
1
−4
−6
11
148
154
1
−5
1
11
30
31
1


4
−6
10
22
19
1
0
1
10
177
176
1
4
8
10
44
44
1
−3
−6
11
42
38
1
−4
1
11
130
130
1


5
−6
10
97
99
1
1
1
10
45
43
1
−6
9
10
49
48
1
−2
−6
11
109
111
1
−3
1
11
160
159
1


−7
−5
10
80
80
1
2
1
10
25
27
1
−5
9
10
98
98
1
−1
−6
11
69
69
1
−2
1
11
62
66
1


−6
−5
10
13
8
2
3
1
10
89
91
1
−4
9
10
72
68
1
0
−6
11
134
132
1
−1
1
11
12
9
2


−5
−5
10
38
38
1
4
1
10
63
62
1
−3
9
10
22
19
1
1
−6
11
85
85
1
0
1
11
112
112
1


−4
−5
10
56
56
1
5
1
10
73
73
1
−2
9
10
120
123
2
2
−6
11
83
79
1
1
1
11
130
133
1


−3
−5
10
103
106
1
−7
2
10
62
63
1
−1
9
10
41
38
1
3
−6
11
42
38
1
2
1
11
100
104
1


−2
−5
10
152
151
1
−6
2
10
77
77
1
0
9
10
215
219
4
4
−6
11
83
89
1
3
1
11
34
37
1


−1
−5
10
69
73
1
−5
2
10
158
160
1
1
9
10
89
90
1
−7
−5
11
51
52
1
4
1
11
119
116
2


0
−5
10
78
82
1
−4
2
10
81
88
1
2
9
10
74
76
1
−6
−5
11
96
95
1
5
1
11
36
38
1


1
−5
10
79
80
1
−3
2
10
49
47
1
3
9
10
81
74
1
−5
−5
11
76
77
1
−7
2
11
36
35
1


2
−5
10
101
105
1
−2
2
10
38
40
1
4
9
10
29
28
1
−4
−5
11
75
74
1
−6
2
11
57
60
1


3
−5
10
18
19
1
−1
2
10
231
236
2
−5
10
10
79
79
1
−3
−5
11
58
58
1
−5
2
11
129
127
1


4
−5
10
88
92
1
0
2
10
71
68
1
−4
10
10
74
73
1
−2
−5
11
91
98
1
−4
2
11
86
90
1


5
−5
10
88
86
1
1
2
10
180
174
2
−3
10
10
56
60
1
−1
−5
11
6
6
5
−3
2
11
25
25
1


−7
−4
10
63
59
1
2
2
10
189
186
1
−2
10
10
134
140
3
0
−5
11
142
140
1
−2
2
11
145
151
1


−6
−4
10
30
26
1
3
2
10
139
137
1
−1
10
10
34
30
1
1
−5
11
55
60
1
−1
2
11
77
77
1


−5
−4
10
70
70
1
4
2
10
70
73
1
0
10
10
154
150
3
2
−5
11
98
100
1
0
2
11
236
235
2


−4
−4
10
36
38
1
5
2
10
70
73
1
1
10
10
137
136
1
3
−5
11
90
89
1
1
2
11
117
119
1


−3
−4
10
90
85
1
−7
3
10
34
36
1
2
10
10
59
57
1
4
−5
11
59
59
1
2
2
11
57
59
1


−2
−4
10
76
76
1
−6
3
10
120
121
1
3
10
10
17
16
1
−7
−4
11
81
81
1
3
2
11
66
65
1


−1
−4
10
183
175
1
−5
3
10
286
282
3
−5
11
10
28
30
1
−6
−4
11
123
126
2
4
2
11
121
125
2


0
−4
10
152
153
1
−4
3
10
225
223
3
−4
11
10
66
61
1
−5
−4
11
197
198
2
5
2
11
71
72
1


1
−4
10
85
82
1
−3
3
10
157
159
1
−3
11
10
73
75
1
−4
−4
11
137
137
1
−6
3
11
104
102
2


−5
3
11
155
149
2
−3
12
11
68
67
1
4
−2
12
94
97
1
−4
7
12
135
142
1
−3
−2
13
109
114
1


−4
3
11
295
302
4
0
12
11
69
70
1
−7
−1
12
37
34
1
−3
7
12
10
17
4
−2
−2
13
76
76
1


−3
3
11
64
67
1
1
12
11
55
49
1
−6
−1
12
80
79
1
−2
7
12
67
67
2
−1
−2
13
65
65
1


−2
3
11
117
117
1
−3
−11
12
73
75
1
−5
−1
12
24
21
1
−1
7
12
119
115
2
0
−2
13
54
54
1


−1
3
11
197
202
2
−2
−11
12
23
23
1
−4
−1
12
141
138
2
0
7
12
99
94
1
1
−2
13
48
50
1


0
3
11
141
130
1
−1
−11
12
113
109
1
−3
−1
12
63
65
1
1
7
12
22
20
1
2
−2
13
20
17
1


1
3
11
188
191
2
0
−11
12
60
59
1
−2
−1
12
117
120
1
2
7
12
61
61
1
−6
−1
13
48
45
1


2
3
11
66
73
1
−4
−10
12
60
57
1
−1
−1
12
64
67
1
3
7
12
101
98
1
−5
−1
13
71
72
1


3
3
11
139
141
1
−3
−10
12
46
47
1
0
−1
12
29
31
1
−5
8
12
95
96
1
−4
−1
13
58
57
1


4
3
11
33
34
1
−2
−10
12
92
87
1
1
−1
12
76
75
1
−4
8
12
50
47
1
−3
−1
13
163
164
1


−6
4
11
126
127
1
−1
−10
12
122
121
1
2
−1
12
25
28
1
−3
8
12
173
177
1
−2
−1
13
26
23
1


−5
4
11
197
198
2
0
−10
12
53
50
1
3
−1
12
37
34
1
−2
8
12
166
161
3
−1
−1
13
109
106
1


−4
4
11
131
136
1
1
−10
12
81
78
1
4
−1
12
36
34
1
−1
8
12
50
53
1
0
−1
13
108
108
1


−3
4
11
140
144
1
−4
−9
12
109
102
1
−6
0
12
74
76
1
0
8
12
72
70
1
1
−1
13
70
68
1


−2
4
11
70
65
1
−3
−9
12
26
25
1
−5
0
12
50
51
1
1
8
12
91
87
1
2
−1
13
40
39
1


−1
4
11
51
47
1
−2
−9
12
62
61
1
−4
0
12
54
49
1
2
8
12
76
73
1
−6
0
13
62
60
1


0
4
11
34
25
1
−1
−9
12
81
84
1
−3
0
12
156
161
1
−5
9
12
10
13
2
−5
0
13
88
85
1


1
4
11
97
104
1
0
−9
12
39
40
1
−2
0
12
110
106
1
−4
9
12
111
102
1
−4
0
13
13
1
2


2
4
11
205
206
2
1
−9
12
60
59
1
−1
0
12
46
52
1
−3
9
12
28
25
1
−3
0
13
48
51
1


3
4
11
43
42
1
−4
−8
12
50
47
1
0
0
12
186
187
2
−2
9
12
60
61
2
−2
0
13
25
24
1


4
4
11
18
20
1
−3
−8
12
175
177
1
1
0
12
25
27
1
−1
9
12
80
84
2
−1
0
13
72
75
1


−6
5
11
97
95
1
−2
−8
12
163
161
1
2
0
12
91
91
1
0
9
12
38
39
1
0
0
13
44
48
1


−5
5
11
76
77
2
−1
−8
12
52
53
1
3
0
12
60
62
1
1
9
12
60
59
1
1
0
13
41
44
1


−4
5
11
71
74
1
0
−8
12
72
69
1
4
0
12
38
41
1
2
9
12
6
4
5
2
0
13
30
30
1


−3
5
11
58
59
1
1
−8
12
89
87
1
−6
1
12
77
78
1
−4
10
12
60
57
1
3
0
13
12
11
1


−2
5
11
92
98
1
−4
−7
12
136
143
1
−5
1
12
25
21
1
−3
10
12
44
46
1
−6
1
13
46
45
1


−1
5
11
6
5
5
−3
−7
12
16
17
1
−4
1
12
140
138
2
−2
10
12
88
87
2
−5
1
13
71
72
1


0
5
11
143
140
1
−2
−7
12
66
68
1
−3
1
12
63
65
1
−1
10
12
118
121
2
−4
1
13
57
57
1


1
5
11
56
60
1
−1
−7
12
118
115
1
−2
1
12
119
120
1
0
10
12
52
50
1
−3
1
13
166
164
1


2
5
11
99
100
1
0
−7
12
98
94
1
−1
1
12
65
67
1
1
10
12
80
77
1
−2
1
13
25
24
1


3
5
11
90
89
1
1
−7
12
24
20
1
0
1
12
31
31
1
−3
11
12
73
75
1
−1
1
13
110
106
1


4
5
11
59
59
1
2
−7
12
63
62
1
1
1
12
74
75
1
0
11
12
60
59
1
0
1
13
113
108
2


−6
6
11
51
52
1
3
−7
12
97
98
2
2
1
12
27
29
1
−3
−10
13
25
23
1
1
1
13
70
68
1


−5
6
11
104
98
1
−6
−6
12
91
94
1
3
1
12
37
33
1
−2
−10
13
21
19
1
2
1
13
39
39
1


−4
6
11
147
153
2
−5
−6
12
88
84
1
4
1
12
36
34
1
−1
−10
13
128
124
1
3
1
13
22
21
1


−3
6
11
41
38
1
−4
−6
12
98
97
1
−6
2
12
82
81
1
0
−10
13
45
43
1
−6
2
13
106
107
2


−2
6
11
110
111
2
−3
−6
12
73
73
1
−5
2
12
69
69
1
−4
−9
13
76
75
1
−5
2
13
31
29
1


−1
6
11
71
69
1
−2
−6
12
84
78
1
−4
2
12
72
74
1
−3
−9
13
151
147
1
−4
2
13
145
147
2


0
6
11
135
132
1
−1
−6
12
74
74
1
−3
2
12
115
109
1
−2
−9
13
68
66
1
−3
2
13
112
113
1


1
6
11
86
85
1
0
−6
12
117
114
1
−2
2
12
57
59
1
−1
−9
13
38
35
1
−2
2
13
79
77
1


2
6
11
83
79
1
1
−6
12
57
57
1
−1
2
12
55
55
1
0
−9
13
75
71
1
−1
2
13
66
66
1


3
6
11
43
38
1
2
−6
12
81
78
1
0
2
12
224
227
2
1
−9
13
34
32
1
0
2
13
56
54
1


4
6
11
86
89
1
3
−6
12
78
76
1
1
2
12
120
128
1
−4
−8
13
115
115
1
1
2
13
47
49
1


−6
7
11
70
66
1
−6
−5
12
135
138
2
2
2
12
102
101
1
−3
−8
13
49
46
1
2
2
13
22
18
1


−5
7
11
31
35
1
−5
−5
12
176
175
3
3
2
12
84
84
1
−2
−8
13
114
109
1
3
2
13
51
51
1


−4
7
11
125
128
1
−4
−5
12
25
23
1
−6
3
12
15
11
2
−1
−8
13
45
48
1
−6
3
13
55
53
1


−3
7
11
61
66
2
−3
−5
12
65
63
1
−5
3
12
97
95
1
0
−8
13
19
20
1
−5
3
13
109
106
1


−2
7
11
122
119
2
−2
−5
12
67
67
1
−4
3
12
59
67
2
1
−8
13
90
84
1
−4
3
13
39
42
1


−1
7
11
124
126
2
−1
−5
12
25
28
1
−3
3
12
154
161
1
−4
−7
13
99
98
1
−3
3
13
98
95
1


0
7
11
156
150
2
0
−5
12
100
97
1
−2
3
12
79
77
1
−3
−7
13
61
60
1
−2
3
13
42
39
1


1
7
11
34
41
1
1
−5
12
137
141
1
−1
3
12
220
217
3
−2
−7
13
35
36
1
−1
3
13
69
64
1


2
7
11
68
69
1
2
−5
12
92
92
1
0
3
12
179
174
2
−1
−7
13
64
60
1
0
3
13
191
199
3


3
7
11
25
28
1
3
−5
12
53
54
1
1
3
12
80
90
1
0
−7
13
95
95
1
1
3
13
72
74
1


4
7
11
57
57
1
4
−5
12
13
13
1
2
3
12
68
67
1
1
−7
13
42
42
1
2
3
13
69
66
1


−6
8
11
50
51
1
−6
−4
12
120
122
2
3
3
12
129
132
1
−5
−6
13
38
39
1
3
3
13
98
96
1


−5
8
11
51
50
1
−5
−4
12
54
55
1
−6
4
12
117
122
1
−4
−6
13
108
108
1
−6
4
13
28
31
1


−4
8
11
115
117
1
−4
−4
12
122
121
1
−5
4
12
54
54
1
−3
−6
13
94
91
1
−5
4
13
105
105
2


−3
8
11
67
71
1
−3
−4
12
138
140
1
−4
4
12
114
121
1
−2
−6
13
6
8
4
−4
4
13
106
103
1


−2
8
11
51
49
2
−2
−4
12
132
128
1
−3
4
12
140
140
1
−1
−6
13
20
19
1
−3
4
13
87
84
1


−1
8
11
119
121
2
−1
−4
12
79
85
1
−2
4
12
134
129
1
0
−6
13
25
24
1
−2
4
13
106
109
1


0
8
11
123
125
1
0
−4
12
125
119
1
−1
4
12
80
84
1
1
−6
13
91
96
1
−1
4
13
123
111
1


1
8
11
92
93
1
1
−4
12
103
103
1
0
4
12
131
119
1
−5
−5
13
139
137
2
0
4
13
144
146
1


2
8
11
61
64
1
2
−4
12
47
48
1
1
4
12
94
103
1
−4
−5
13
88
87
1
1
4
13
72
73
1


3
8
11
58
61
1
3
−4
12
45
49
1
2
4
12
47
48
1
−3
−5
13
29
25
1
2
4
13
102
102
1


−5
9
11
114
111
1
4
−4
12
20
22
1
3
4
12
47
49
1
−2
−5
13
122
126
1
3
4
13
46
44
1


−4
9
11
129
129
1
−6
−3
12
15
11
2
−6
5
12
136
138
1
−1
−5
13
63
66
1
−6
5
13
55
57
1


−3
9
11
105
108
1
−5
−3
12
97
96
1
−5
5
12
181
175
3
0
−5
13
120
116
1
−5
5
13
140
137
2


−2
9
11
132
132
2
−4
−3
12
67
67
1
−4
5
12
26
23
1
1
−5
13
56
56
1
−4
5
13
89
87
1


−1
9
11
91
91
2
−3
−3
12
150
162
1
−3
5
12
64
63
1
2
−5
13
18
15
1
−3
5
13
28
25
1


0
9
11
50
47
1
−2
−3
12
78
77
1
−2
5
12
66
66
1
−5
−4
13
100
105
2
−2
5
13
120
126
1


1
9
11
117
121
1
−1
−3
12
220
218
2
−1
5
12
25
28
1
−4
−4
13
106
104
1
−1
5
13
64
66
1


2
9
11
83
83
1
0
−3
12
173
174
1
0
5
12
104
98
1
−3
−4
13
85
83
1
0
5
13
120
116
1


3
9
11
50
53
1
1
−3
12
91
90
1
1
5
12
134
142
1
−2
−4
13
107
108
1
1
5
13
57
56
1


−5
10
11
25
23
1
2
−3
12
67
67
1
2
5
12
91
91
1
−1
−4
13
123
112
1
2
5
13
19
16
1


−4
10
11
29
30
1
3
−3
12
126
131
2
3
5
12
53
53
1
0
−4
13
142
146
1
3
5
13
52
53
1


−3
10
11
125
126
2
4
−3
12
49
52
1
−6
6
12
94
95
1
1
−4
13
73
74
1
−5
6
13
40
38
1


−2
10
11
71
71
2
−7
−2
12
92
89
1
−5
6
12
88
84
1
2
−4
13
102
102
1
−4
6
13
113
108
1


−1
10
11
65
63
1
−6
−2
12
81
82
1
−4
6
12
97
97
1
−5
−3
13
107
106
1
−3
6
13
94
90
1


0
10
11
88
91
1
−5
−2
12
67
68
1
−3
6
12
73
74
1
−4
−3
13
41
42
1
−2
6
13
9
8
5


1
10
11
106
101
1
−4
−2
12
74
74
1
−2
6
12
86
78
2
−3
−3
13
90
94
1
−1
6
13
19
19
2


2
10
11
84
88
1
−3
−2
12
112
108
1
−1
6
12
74
74
1
−2
−3
13
40
39
1
0
6
13
25
24
1


−4
11
11
72
71
1
−2
−2
12
56
59
1
0
6
12
118
113
1
−1
−3
13
67
64
1
1
6
13
93
96
1


−3
11
11
51
55
1
−1
−2
12
54
55
1
1
6
12
57
57
1
0
−3
13
187
199
1
2
6
13
37
33
1


−2
11
11
68
63
1
0
−2
12
224
228
2
2
6
12
81
78
1
1
−3
13
74
74
1
3
6
13
16
15
1


0
11
11
52
53
1
1
−2
12
126
128
1
3
6
12
81
76
1
2
−3
13
69
66
1
−5
7
13
115
114
1


1
11
11
91
89
1
2
−2
12
98
101
1
−6
7
12
106
105
2
−5
−2
13
29
30
1
−4
7
13
104
98
1


2
11
11
60
62
1
3
−2
12
85
84
1
−5
7
12
83
80
1
−4
−2
13
147
146
2
−3
7
13
61
60
1


−2
7
13
38
35
2
−3
−3
14
21
20
1
2
3
14
50
49
1
−5
−3
15
70
72
1
0
4
15
88
84
1


−1
7
13
63
60
1
−2
−3
14
87
83
1
−5
4
14
62
64
1
−4
−3
15
39
37
1
1
4
15
16
15
1


0
7
13
95
94
1
−1
−3
14
34
34
1
−4
4
14
97
92
1
−3
−3
15
33
36
1
−4
5
15
70
72
1


1
7
13
43
41
1
0
−3
14
90
90
1
−3
4
14
37
33
1
−2
−3
15
22
20
1
−3
5
15
34
26
1


2
7
13
38
35
1
1
−3
14
112
107
1
−2
4
14
96
97
1
−1
−3
15
37
35
1
−2
5
15
11
5
2


−4
8
13
118
114
1
2
−3
14
51
49
1
−1
4
14
85
81
1
0
−3
15
55
53
1
−1
5
15
77
77
1


−3
8
13
49
46
1
−5
−2
14
40
39
1
0
4
14
118
110
1
1
−3
15
35
30
1
0
5
15
38
36
1


−2
8
13
111
108
2
−4
−2
14
164
161
2
1
4
14
72
75
1
−5
−2
15
51
51
1
1
5
15
109
110
1


−1
8
13
43
47
1
−3
−2
14
207
202
2
2
4
14
73
76
1
−4
−2
15
31
30
1
−3
6
15
54
60
1


0
8
13
19
20
1
−2
−2
14
75
77
1
−5
5
14
37
34
1
−3
−2
15
116
120
1
−2
6
15
25
24
1


1
8
13
89
84
1
−1
−2
14
66
66
1
−4
5
14
98
95
1
−2
−2
15
72
68
1
−1
6
15
35
36
1


2
8
13
83
81
1
0
−2
14
85
86
1
−3
5
14
21
22
1
−1
−2
15
83
87
1
0
6
15
37
36
1


−4
9
13
73
75
1
1
−2
14
84
83
1
−2
5
14
84
82
1
0
−2
15
155
149
2
−3
7
15
51
47
1


−3
9
13
147
147
2
2
−2
14
34
37
1
−1
5
14
74
69
1
1
−2
15
44
46
1
−2
7
15
77
80
1


−2
9
13
68
67
1
−5
−1
14
81
85
1
0
5
14
57
57
1
−5
−1
15
26
30
1
−1
7
15
14
11
2


−1
9
13
36
35
1
−4
−1
14
117
117
1
1
5
14
70
70
1
−4
−1
15
85
86
1
−3
−4
16
43
42
1


0
9
13
75
71
1
−3
−1
14
47
44
1
2
5
14
49
47
1
−3
−1
15
56
57
1
−2
−4
16
49
51
1


1
9
13
35
32
1
−2
−1
14
26
26
1
−5
6
14
62
62
1
−2
−1
15
31
34
1
−1
−4
16
30
29
1


−3
10
13
24
23
1
−1
−1
14
78
76
1
−4
6
14
125
120
1
−1
−1
15
149
147
1
−3
−3
16
12
10
1


−1
10
13
125
125
1
0
−1
14
149
148
1
−3
6
14
105
102
1
0
−1
15
40
40
1
−2
−3
16
24
25
1


0
10
13
45
43
1
1
−1
14
48
51
1
−2
6
14
28
27
1
1
−1
15
37
36
1
−1
−3
16
49
50
1


−2
−9
14
64
69
1
2
−1
14
17
15
1
−1
6
14
64
62
1
2
−1
15
55
54
1
0
−3
16
45
43
1


−1
−9
14
52
49
1
−5
0
14
38
37
1
0
6
14
28
22
1
−5
0
15
45
45
1
−4
−2
16
40
41
1


−3
−8
14
26
25
1
−4
0
14
17
19
2
1
6
14
55
53
1
−4
0
15
80
82
1
−3
−2
16
34
30
1


−2
−8
14
66
64
1
−3
0
14
43
42
1
2
6
14
126
129
2
−3
0
15
14
9
1
−2
−2
16
54
57
1


−1
−8
14
34
33
1
−2
0
14
95
97
1
−4
7
14
29
30
1
−2
0
15
42
48
1
−1
−2
16
60
57
1


0
−8
14
85
83
1
−1
0
14
132
132
1
−3
7
14
90
83
1
−1
0
15
5
4
5
0
−2
16
117
118
1


−4
−7
14
30
30
1
0
0
14
81
76
1
−2
7
14
129
129
2
0
0
15
10
12
3
−4
−1
16
89
86
1


−3
−7
14
89
83
1
1
0
14
62
60
1
−1
7
14
33
36
1
1
0
15
12
14
1
−3
−1
16
78
78
1


−2
−7
14
130
129
1
2
0
14
4
2
4
0
7
14
66
64
1
2
0
15
54
48
1
−2
−1
16
12
13
1


−1
−7
14
32
36
1
−6
1
14
59
60
1
1
7
14
15
15
1
−5
1
15
26
30
1
−1
−1
16
104
100
1


0
−7
14
67
64
1
−5
1
14
83
85
1
−3
8
14
27
26
1
−4
1
15
86
86
1
0
−1
16
129
129
1


1
−7
14
15
16
1
−4
1
14
117
117
1
−2
8
14
66
64
1
−3
1
15
57
57
1
−4
0
16
106
108
1


−4
−6
14
120
120
1
−3
1
14
47
44
1
−1
8
14
34
32
1
−2
1
15
34
34
1
−3
0
16
4
6
4


−3
−6
14
103
102
1
−2
1
14
25
26
1
0
8
14
85
82
1
−1
1
15
150
147
1
−2
0
16
40
35
1


−2
−6
14
28
27
1
−1
1
14
79
76
1
−1
9
14
53
49
1
0
1
15
41
40
1
−1
0
16
32
33
1


−1
−6
14
66
63
1
0
1
14
150
148
2
−3
−7
15
50
47
1
1
1
15
35
36
1
0
0
16
30
30
1


0
−6
14
27
22
1
1
1
14
47
51
1
−2
−7
15
77
80
1
2
1
15
53
53
1
−4
1
16
86
86
1


1
−6
14
59
53
1
2
1
14
15
16
1
−1
−7
15
10
11
1
−5
2
15
50
51
1
−3
1
16
79
79
1


−5
−5
14
36
34
1
−6
2
14
21
23
1
−3
−6
15
55
60
1
−4
2
15
27
29
1
−2
1
16
13
13
1


−4
−5
14
96
95
1
−5
2
14
42
40
1
−2
−6
15
26
24
1
−3
2
15
118
119
1
−1
1
16
103
100
1


−3
−5
14
25
22
1
−4
2
14
164
160
1
−1
−6
15
35
35
1
−2
2
15
72
68
1
0
1
16
128
129
1


−2
−5
14
86
82
1
−3
2
14
209
202
2
0
−6
15
36
36
1
−1
2
15
83
87
1
−4
2
16
42
41
1


−1
−5
14
76
69
1
−2
2
14
75
76
1
−4
−5
15
75
73
1
0
2
15
156
149
2
−3
2
16
36
30
1


0
−5
14
54
57
1
−1
2
14
66
66
1
−3
−5
15
30
26
1
1
2
15
47
47
1
−2
2
16
54
57
1


1
−5
14
71
71
1
0
2
14
87
87
1
−2
−5
15
9
5
1
−4
3
15
41
37
1
−1
2
16
60
56
1


−5
−4
14
64
65
1
1
2
14
83
83
1
−1
−5
15
77
77
1
−3
3
15
35
36
1
0
2
16
117
118
1


−4
−4
14
94
92
1
2
2
14
33
37
1
0
−5
15
39
35
1
−2
3
15
19
19
1
−3
3
16
13
11
4


−3
−4
14
35
33
1
−5
3
14
27
22
1
1
−5
15
110
110
2
−1
3
15
38
35
1
−2
3
16
25
25
1


−2
−4
14
98
97
1
−4
3
14
34
32
1
−4
−4
15
21
21
1
0
3
15
56
53
1
−1
3
16
49
49
1


−1
−4
14
86
80
1
−3
3
14
20
20
1
−3
−4
15
8
9
3
1
3
15
35
30
1
0
3
16
45
43
1


0
−4
14
118
111
1
−2
3
14
85
83
1
−2
−4
15
35
32
1
−4
4
15
22
21
1
−3
4
16
42
42
1


1
−4
14
72
75
1
−1
3
14
34
34
1
−1
−4
15
38
37
1
−3
4
15
10
9
1
−2
4
16
49
51
1


−5
−3
14
21
22
1
0
3
14
91
90
1
0
−4
15
86
84
1
−2
4
15
34
32
1
−1
4
16
29
29
1


−4
−3
14
32
32
1
1
3
14
113
107
1
1
−4
15
14
15
2
−1
4
15
39
37
1
















TABLE 9





Crystal data and structure refinement for MET-2.
















Empirical formula
C32H56O4


Formula weight
504.77


Temperature
298(1) K


Wavelength
1.54178 Å


Crystal system, space group
Monoclinic, C2









Unit cell dimensions
a = 27.3382(16) Å
α = 90°



b = 6.6860(13) Å
β = 113.57(3)°



c = 19.221(10) A
γ = 90°








Volume
3320.3(11) Å3


Z
4


Calculated density
1.041 Mg/m3


Absorption coefficient
0.513 mm−1


F(000)
1120


Crystal size
0.36 × 0.17 × 0.03 mm


Theta range for data collection
2.51 to 58.69°


Limiting indices
−29 <= h <= 28, −6 <= k <= 6,



−21 <= l <= 21


Reflections collected/unique
10383/3985 [R(int) = 0.0473]


Data/restraints/parameters
3985/1/325


Goodness-of-fit on F2
1.073


Final R indices [I > 2σ(I)]
R1 = 0.0618, wR2 = 0.1600


R indices (all data)
R1 = 0.0844, wR2 = 0.1778


Absolute structure parameter
0.2(4)


Largest diff. peak and hole
0.140 and −0.190 e/Å−3
















TABLE 10







Atomic coordinates (Å2 × 104) and equivalent isotropic


displacement parameters (Å2 × 103) for MET-2 U(eq)


is defined as one third of the trace of the orthogonalized Uij tensor.












x
y
z
U(eq)
















O(3)
9651(1)
8018(5)
3345(2)
80(1)



C(20)
7634(1)
8343(6)
−2763(2)
67(1)



O(25)
9328(1)
7952(6)
−3391(2)
102(1)



C(13)
7985(1)
7574(6)
−1301(2)
59(1)



C(1)
9449(2)
12075(6) 
2708(2)
66(1)



C(17)
8118(1)
8204(6)
−1982(2)
59(1)



O(1)
9565(1)
14167(5) 
2735(2)
88(1)



C(10)
8922(2)
11685(7) 
2036(2)
73(1)



C(23)
8253(2)
8546(7)
−3469(2)
70(1)



C(2)
9409(2)
11384(7) 
3438(2)
67(1)



C(12)
7838(2)
5387(7)
−1291(2)
74(1)



C(14)
8539(1)
7926(6)
−637(2)
64(1)



C(22)
7766(2)
7484(7)
−3431(2)
69(1)



C(18)
7564(2)
8908(7)
−1201(3)
79(1)



C(5)
8739(2)
9568(7)
2011(2)
68(1)



C(3)
9242(2)
9248(7)
3413(2)
68(1)



C(15)
8704(2)
9975(8)
−812(2)
77(1)



C(9)
8370(2)
5285(7)
139(2)
83(1)



C(16)
8471(2)
10076(7) 
−1687(2)
76(1)



C(25)
8924(2)
 8719(10)
−4091(2)
93(2)



C(8)
8525(2)
7441(7)
118(2)
69(1)



C(30)
7870(2)
5245(7)
−3306(3)
98(2)



C(28)
7279(2)
 7779(10)
−4185(2)
103(2)



C(24)
8394(2)
 7945(10)
−4124(2)
91(2)



C(11)
7843(2)
4765(8)
−517(2)
83(1)



C(4)
8712(2)
8882(8)
2740(2)
74(1)



C(27)
8974(2)
10999(12)
−4028(4)
134(3)



C(6)
8624(1)
8330(8)
1421(2)
72(1)



C(21)
7379(2)
10414(8) 
−2945(3)
98(2)



C(26)
9029(2)
 7983(18)
−4745(3)
177(4)



C(7)
8639(2)
8753(7)
686(2)
72(1)



C(29)
9490(2)
12565(9) 
4016(2)
97(2)



O(201)
10425(1)
14824(6) 
2396(2)
112(1)



C(202)
10381(3)
15282(14)
1660(3)
128(2)



C(201)
10109(4)
17151(16)
1381(5)
185(4)



C(203)
10130(5)
13539(17)
1161(5)
223(5)
















TABLE 11





Bond lengths [Å] for MET-2.


















O(3)—C(3)
1.434(5)



C(20)—C(21)
1.527(6)



C(20)—C(17)
1.558(5)



C(20)—C(22)
1.573(5)



O(25)—C(25)
1.451(5)



C(13)—C(12)
1.518(6)



C(13)—C(18)
1.527(6)



C(13)—C(17)
1.549(5)



C(13)—C(14)
1.560(5)



C(1)—O(1)
1.431(5)



C(1)—C(2)
1.521(5)



C(1)—C(10)
1.524(6)



C(17)—C(16)
1.543(6)



C(10)—C(5)
1.495(6)



C(23)—C(24)
1.511(5)



C(23)—C(22)
1.535(6)



C(2)—C(29)
1.308(6)



C(2)—C(3)
1.495(6)



C(12)—C(11)
1.541(5)



C(14)—C(8)
1.501(5)



C(14)—C(15)
1.522(6)



C(22)—C(30)
1.524(7)



C(22)—C(28)
1.541(6)



C(5)—C(6)
1.336(6)



C(5)—C(4)
1.505(5)



C(3)—C(4)
1.527(5)



C(15)—C(16)
1.543(5)



C(9)—C(8)
1.508(7)



C(9)—C(11)
1.527(6)



C(25)—C(26)
1.483(8)



C(25)—C(24)
1.516(7)



C(25)—C(27)
1.532(9)



C(8)—C(7)
1.336(6)



C(6)—C(7)
1.458(5)



O(201)—C(202)
1.405(7)



C(202)—C(201)
1.443(11)



C(202)—C(203)
1.490(11)
















TABLE 12





bond angles [°] for MET-2.


















C(21)—C(20)—C(17)
114.1(3)



C(21)—C(20)—C(22)
112.2(4)



C(17)—C(20)—C(22)
112.4(3)



C(12)—C(13)—C(18)
110.1(3)



C(12)—C(13)—C(17)
115.2(3)



C(18)—C(13)—C(17)
113.0(3)



C(12)—C(13)—C(14)
108.1(3)



C(18)—C(13)—C(14)
110.0(3)



C(17)—C(13)—C(14)
99.8(3)



O(1)—C(1)—C(2)
111.1(3)



O(1)—C(1)—C(10)
108.7(4)



C(2)—C(1)—C(10)
109.7(3)



C(16)—C(17)—C(13)
103.5(3)



C(16)—C(17)—C(20)
118.1(3)



C(13)—C(17)—C(20)
115.7(3)



C(5)—C(10)—C(1)
112.3(3)



C(24)—C(23)—C(22)
115.5(4)



C(29)—C(2)—C(3)
123.4(4)



C(29)—C(2)—C(1)
123.4(4)



C(3)—C(2)—C(1)
113.2(3)



C(13)—C(12)—C(11)
111.8(3)



C(8)—C(14)—C(15)
122.2(3)



C(8)—C(14)—C(13)
111.5(3)



C(15)—C(14)—C(13)
103.4(3)



C(30)—C(22)—C(23)
110.6(4)



C(30)—C(22)—C(28)
108.1(4)



C(23)—C(22)—C(28)
109.6(3)



C(30)—C(22)—C(20)
108.7(3)



C(23)—C(22)—C(20)
110.8(3)



C(28)—C(22)—C(20)
109.1(3)



C(6)—C(5)—C(10)
125.2(4)



C(6)—C(5)—C(4)
121.3(4)



C(10)—C(5)—C(4)
113.5(4)



O(3)—C(3)—C(2)
108.1(3)



O(3)—C(3)—C(4)
109.9(3)



C(2)—C(3)—C(4)
110.8(4)



C(14)—C(15)—C(16)
104.5(3)



C(8)—C(9)—C(11)
112.2(4)



C(17)—C(16)—C(15)
106.9(3)



O(25)—C(25)—C(26)
109.6(5)



O(25)—C(25)—C(24)
106.2(4)



C(26)—C(25)—C(24)
111.0(5)



O(25)—C(25)—C(27)
105.5(5)



C(26)—C(25)—C(27)
110.8(6)



C(24)—C(25)—C(27)
113.4(5)



C(7)—C(8)—C(14)
124.1(4)



C(7)—C(8)—C(9)
125.5(4)



C(14)—C(8)—C(9)
110.4(3)



C(23)—C(24)—C(25)
115.6(4)



C(9)—C(11)—C(12)
112.2(3)



C(5)—C(4)—C(3)
110.9(3)



C(5)—C(6)—C(7)
127.9(4)



C(8)—C(7)—C(6)
125.2(4)



O(201)—C(202)—C(201)
112.8(6)



O(201)—C(202)—C(203)
108.1(7)



C(201)—C(202)—C(203)
113.8(7)
















TABLE 13







Anisotropic displacement parameters (Å2 × 103) for MET-2. The


anisotropic displacement factor exponent takes the form


“−2π2[h2a * 2U11 + + 2hka * b * U12]














U11
U22
U33
U23
U13
U12

















O(3)
67(2)
71(2)
93(2)
 −5(2)
22(1)
 −7(2)


C(20)
58(2)
70(3)
67(2)
 −4(2)
20(2)
 −6(2)


O(25)
79(2)
144(3) 
86(2)
 43(2)
36(2)
 34(2)


C(13)
63(2)
53(3)
67(2)
−10(2)
31(2)
 −4(2)


C(1)
73(3)
52(3)
75(3)
 −5(2)
31(2)
 −8(2)


C(17)
53(2)
65(3)
60(2)
−10(2)
23(2)
−12(2)


O(1)
102(2) 
67(2)
87(2)
−11(2)
31(2)
−14(2)


C(10)
76(3)
76(3)
60(2)
 −6(2)
18(2)
 −3(2)


C(23)
65(2)
79(3)
65(2)
 −1(2)
25(2)
 −7(2)


C(2)
62(2)
73(3)
63(2)
 −7(2)
21(2)
 −5(2)


C(12)
88(3)
74(3)
65(2)
−12(2)
37(2)
−23(2)


C(14)
65(2)
65(3)
63(2)
 −9(2)
27(2)
−11(2)


C(22)
61(2)
79(3)
64(2)
 −9(2)
21(2)
−16(2)


C(18)
68(2)
86(3)
91(3)
−20(2)
38(2)
 −8(2)


C(5)
54(2)
82(3)
58(2)
 −6(2)
14(2)
−13(2)


C(3)
68(2)
76(3)
59(2)
 −4(2)
24(2)
 −9(2)


C(15)
78(3)
82(3)
71(2)
−11(2)
30(2)
−23(3)


C(9)
106(3) 
76(3)
68(2)
 −4(2)
38(2)
−11(3)


C(16)
73(3)
80(3)
73(2)
 −7(2)
26(2)
−26(2)


C(25)
68(3)
146(6) 
64(3)
 17(3)
24(2)
 3(3)


C(8)
66(2)
72(3)
65(2)
 −4(2)
22(2)
 −6(2)


C(30)
152(5) 
58(3)
103(3) 
−15(3)
70(3)
−17(3)


C(28)
76(3)
148(5) 
71(3)
 −6(3)
16(2)
−18(3)


C(24)
81(3)
129(5) 
65(2)
 −4(3)
31(2)
−11(3)


C(11)
108(3) 
78(3)
76(3)
−16(2)
49(3)
−37(3)


C(4)
60(2)
97(4)
67(2)
 −2(2)
28(2)
−14(2)


C(27)
75(4)
156(7) 
150(5) 
 72(5)
22(3)
−12(4)


C(6)
60(2)
84(3)
67(2)
 −7(2)
20(2)
−19(2)


C(21)
88(3)
94(4)
103(3) 
 10(3)
26(3)
 32(3)


C(26)
137(5) 
337(12)
83(3)
 −5(6)
72(4)
−23(7)


C(7)
65(2)
81(3)
60(2)
 −4(2)
15(2)
−17(2)


C(29)
125(4) 
92(4)
69(3)
−10(3)
35(3)
 −8(3)


O(201)
123(3) 
122(3) 
96(2)
−17(2)
51(2)
−23(2)


C(202)
113(4) 
180(8) 
101(4) 
 −8(5)
54(4)
−21(5)


C(201)
192(8) 
180(9) 
152(7) 
 42(6)
36(6)
 15(8)


C(203)
305(13)
227(11)
134(6) 
−84(7)
85(7)
 −25(10)
















TABLE 14







Hydrogen coordinates (Å2 × 104) and isotropic


displacement parameters (Å2 × 103) for MET-2.












x
y
z
U(eq)
















H(3A)
9521
6950
3147
120



H(20I)
7360
7457
−2725
80



H(25A)
9621
8007
−3413
153



H(1A)
9733
11326
2636
79



H(17A)
8352
7159
−2035
71



H(1B)
9853
14390
3088
131



H(10A)
8651
12572
2069
88



H(10B)
8963
11988
1569
88



H(23A)
8187
9976
−3499
84



H(23B)
8559
8290
−2999
84



H(12A)
8088
4563
−1405
88



H(12B)
7484
5157
−1683
88



H(14A)
8784
6962
−710
77



H(18A)
7495
8444
−777
119



H(18B)
7241
8859
−1653
119



H(18C)
7693
10260
−1111
119



H(3B)
9203
8917
3885
82



H(15A)
9090
10101
−603
92



H(15B)
8558
11029
−605
92



H(9A)
8338
5027
616
99



H(9B)
8649
4428
116
99



H(16A)
8260
11280
−1864
92



H(16B)
8756
10086
−1867
92



H(30A)
7954
4704
−3709
147



H(30B)
7558
4597
−3304
147



H(30C)
8165
5024
−2829
147



H(28A)
7358
7266
−4595
154



H(28B)
7197
9178
−4264
154



H(28C)
6978
7076
−4166
154



H(24A)
8114
8414
−4591
109



H(24B)
8398
6496
−4147
109



H(11A)
7553
5434
−441
100



H(11B)
7783
3335
−517
100



H(4A)
8627
7467
2706
89



H(4B)
8430
9599
2818
89



H(27A)
9317
11395
−4006
201



H(27B)
8937
11432
−3575
201



H(27C)
8699
11600
−4462
201



H(6A)
8522
7041
1487
87



H(21A)
7302
10877
−2527
148



H(21B)
7054
10341
−3393
148



H(21C)
7620
11328
−3030
148



H(26A)
8994
6554
−4776
265



H(26B)
9385
8347
−4679
265



H(26C)
8778
8571
−5205
265



H(7A)
8736
10038
606
86



H(29A)
9444
12086
4440
116



H(29B)
9594
13885
4003
116



H(20A)
10540
15801
2672
167



H(20B)
10744
15418
1682
154



H(20C)
10300
18216
1714
278



H(20D)
9753
17079
1362
278



H(20E)
10094
17402
881
278



H(20F)
10095
13823
653
334



H(20G)
9784
13292
1161
334



H(20H)
10351
12378
1348
334
















TABLE 15





Torsion angles [deg] for MET-2.


















C(12)—C(13)—C(17)—C(16)
−156.5(4)



C(18)—C(13)—C(17)—C(16)
75.8(4)



C(14)—C(13)—C(17)—C(16)
−41.0(4)



C(12)—C(13)—C(17)—C(20)
72.7(5)



C(18)—C(13)—C(17)—C(20)
−55.1(4)



C(14)—C(13)—C(17)—C(20)
−171.9(3)



C(21)—C(20)—C(17)—C(16)
−32.0(5)



C(22)—C(20)—C(17)—C(16)
97.2(4)



C(21)—C(20)—C(17)—C(13)
91.5(5)



C(22)—C(20)—C(17)—C(13)
−139.3(4)



O(1)—C(1)—C(10)—C(5)
−174.1(4)



C(2)—C(1)—C(10)—C(5)
−52.4(5)



O(1)—C(1)—C(2)—C(29)
−2.0(6)



C(10)—C(1)—C(2)—C(29)
−122.2(5)



O(1)—C(1)—C(2)—C(3)
175.1(4)



C(10)—C(1)—C(2)—C(3)
54.9(5)



C(18)—C(13)—C(12)—C(11)
−64.5(5)



C(17)—C(13)—C(12)—C(11)
166.3(3)



C(14)—C(13)—C(12)—C(11)
55.7(4)



C(12)—C(13)—C(14)—C(8)
−59.9(4)



C(18)—C(13)—C(14)—C(8)
60.3(5)



C(17)—C(13)—C(14)—C(8)
179.4(3)



C(12)—C(13)—C(14)—C(15)
167.1(3)



C(18)—C(13)—C(14)—C(15)
−72.7(4)



C(17)—C(13)—C(14)—C(15)
46.3(4)



C(24)—C(23)—C(22)—C(30)
63.6(5)



C(24)—C(23)—C(22)—C(28)
−55.4(5)



C(24)—C(23)—C(22)—C(20)
−175.9(4)



C(21)—C(20)—C(22)—C(30)
−164.4(4)



C(17)—C(20)—C(22)—C(30)
65.4(4)



C(21)—C(20)—C(22)—C(23)
73.9(4)



C(17)—C(20)—C(22)—C(23)
−56.3(5)



C(21)—C(20)—C(22)—C(28)
−46.8(5)



C(17)—C(20)—C(22)—C(28)
−177.0(4)



C(1)—C(10)—C(5)—C(6)
−124.5(4)



C(1)—C(10)—C(5)—C(4)
53.4(5)



C(29)—C(2)—C(3)—O(3)
−118.5(5)



C(1)—C(2)—C(3)—O(3)
64.5(4)



C(29)—C(2)—C(3)—C(4)
121.0(5)



C(1)—C(2)—C(3)—C(4)
−56.1(4)



C(8)—C(14)—C(15)—C(16)
−159.9(4)



C(13)—C(14)—C(15)—C(16)
−33.4(4)



C(13)—C(17)—C(16)—C(15)
21.6(4)



C(20)—C(17)—C(16)—C(15)
151.0(3)



C(14)—C(15)—C(16)—C(17)
7.3(5)



C(15)—C(14)—C(8)—C(7)
2.0(6)



C(13)—C(14)—C(8)—C(7)
−120.8(4)



C(15)—C(14)—C(8)—C(9)
−177.6(4)



C(13)—C(14)—C(8)—C(9)
59.6(5)



C(11)—C(9)—C(8)—C(7)
125.6(4)



C(11)—C(9)—C(8)—C(14)
−54.8(5)



C(22)—C(23)—C(24)—C(25)
−170.1(4)



O(25)—C(25)—C(24)—C(23)
59.0(6)



C(26)—C(25)—C(24)—C(23)
178.1(6)



C(27)—C(25)—C(24)—C(23)
−56.4(6)



C(8)—C(9)—C(11)—C(12)
51.6(6)



C(13)—C(12)—C(11)—C(9)
−53.0(5)



C(6)—C(5)—C(4)—C(3)
124.7(4)



C(10)—C(5)—C(4)—C(3)
−53.3(5)



O(3)—C(3)—C(4)—C(5)
−65.7(5)



C(2)—C(3)—C(4)—C(5)
53.8(5)



C(10)—C(5)—C(6)—C(7)
−1.2(7)



C(4)—C(5)—C(6)—C(7)
−179.0(4)



C(14)—C(8)—C(7)—C(6)
179.4(4)



C(9)—C(8)—C(7)—C(6)
−1.1(7)



C(5)—C(6)—C(7)—C(8)
179.2(4)
















TABLE 16







Observed and calculated structure factors for MET-2.




































h
k
l
10Fo
10Fc
10s
h
k
l
10Fo
10Fc
10s
h
k
l
10Fo
10Fc
10s
h
k
l
10Fo
10Fc
10s
h
k
l
10Fo
10Fc
10s







































16
−6
0
23
6
23
8
2
0
224
220
8
−15
−3
1
173
173
6
0
0
1
381
388
6
−12
4
1
124
117
4


9
−5
0
179
178
8
10
2
0
276
310
10
−13
−3
1
172
175
6
2
0
1
833
936
12
−10
4
1
197
179
4


11
−5
0
59
52
13
12
2
0
175
180
7
−11
−3
1
115
118
5
4
0
1
1025
1083
15
−8
4
1
91
99
4


13
−5
0
99
92
9
14
2
0
56
63
14
−9
−3
1
240
217
8
6
0
1
570
567
9
−6
4
1
295
284
5


15
−5
0
0
21
1
18
2
0
194
198
6
−7
−3
1
205
199
8
8
0
1
1171
1214
18
−4
4
1
213
211
4


17
−5
0
60
46
13
20
2
0
86
102
12
−5
−3
1
348
327
10
10
0
1
73
67
4
−2
4
1
387
390
4


19
−5
0
23
27
23
22
2
0
76
77
13
−3
−3
1
592
563
18
12
0
1
331
349
8
0
4
1
224
227
3


4
−4
0
167
167
8
24
2
0
110
145
10
−1
−3
1
463
464
10
14
0
1
13
30
13
2
4
1
452
446
5


6
−4
0
204
189
5
26
2
0
23
38
22
1
−3
1
614
614
12
16
0
1
59
53
7
4
4
1
237
239
4


8
−4
0
112
93
8
1
3
0
862
875
14
3
−3
1
295
286
9
18
0
1
215
210
8
6
4
1
54
49
5


10
−4
0
72
88
8
3
3
0
361
364
7
5
−3
1
244
265
9
20
0
1
0
10
1
8
4
1
68
55
5


12
−4
0
183
165
6
7
3
0
457
449
16
7
−3
1
236
224
9
22
0
1
58
50
20
10
4
1
69
74
5


14
−4
0
196
198
9
9
3
0
222
220
9
9
−3
1
245
235
6
24
0
1
91
86
5
12
4
1
97
91
5


16
−4
0
175
189
8
15
3
0
145
135
11
11
−3
1
122
109
7
−23
1
1
65
87
16
14
4
1
169
156
9


18
−4
0
40
45
24
17
3
0
220
212
8
13
−3
1
157
144
6
−21
1
1
352
352
5
16
4
1
112
138
9


20
−4
0
30
28
30
19
3
0
126
122
9
15
−3
1
72
59
9
−19
1
1
221
213
3
18
4
1
109
114
9


22
−4
0
0
22
1
21
3
0
67
69
15
17
−3
1
171
169
9
−17
1
1
202
194
3
20
4
1
32
31
32


1
−3
0
869
873
18
23
3
0
59
59
16
19
−3
1
52
50
17
−15
1
1
147
143
3
22
4
1
0
11
1


3
−3
0
364
365
11
25
3
0
0
32
1
21
−3
1
72
59
14
−13
1
1
416
412
16
−21
5
1
33
19
33


5
−3
0
400
372
12
0
4
0
429
436
6
23
−3
1
46
46
13
−11
1
1
902
941
20
−19
5
1
0
34
1


7
−3
0
476
447
14
2
4
0
403
390
5
−26
−2
1
61
57
9
−9
1
1
403
389
6
−17
5
1
92
86
10


9
−3
0
232
220
5
4
4
0
170
167
5
−24
−2
1
97
102
16
−7
1
1
587
602
9
−15
5
1
143
128
6


11
−3
0
252
248
6
6
4
0
208
189
4
−22
−2
1
212
217
6
−5
1
1
1112
1157
19
−13
5
1
157
146
5


13
−3
0
126
117
7
8
4
0
111
93
4
−20
−2
1
199
190
5
−3
1
1
965
1044
30
−11
5
1
133
125
5


15
−3
0
138
135
6
10
4
0
77
89
5
−18
−2
1
47
54
10
−1
1
1
1304
1398
16
−9
5
1
41
24
11


17
−3
0
214
212
6
12
4
0
169
165
4
−16
−2
1
214
194
5
1
1
1
1131
1213
15
−7
5
1
110
106
6


19
−3
0
110
122
9
14
4
0
190
198
6
−14
−2
1
274
254
5
3
1
1
395
453
5
−5
5
1
309
295
6


21
−3
0
71
69
13
16
4
0
184
189
8
−12
−2
1
87
85
6
5
1
1
501
544
7
−3
5
1
147
145
3


23
−3
0
41
59
24
18
4
0
52
45
18
−10
−2
1
433
429
14
7
1
1
556
601
7
−1
5
1
28
32
9


25
−3
0
16
32
16
20
4
0
0
28
1
−8
−2
1
134
160
6
9
1
1
322
313
6
1
5
1
90
83
3


0
−2
0
1263
1370
38
22
4
0
41
22
34
−6
−2
1
255
251
6
11
1
1
175
185
13
3
5
1
26
29
13


2
−2
0
379
408
10
1
5
0
130
130
3
−4
−2
1
474
505
10
13
1
1
363
359
8
5
5
1
119
122
5


4
−2
0
107
94
4
3
5
0
66
73
4
−2
−2
1
245
257
5
15
1
1
412
413
5
7
5
1
97
91
6


6
−2
0
224
223
6
5
5
0
35
25
12
0
−2
1
731
763
15
17
1
1
46
47
7
9
5
1
110
108
5


8
−2
0
202
222
13
7
5
0
98
95
6
2
−2
1
266
299
5
19
1
1
162
160
3
11
5
1
130
133
5


10
−2
0
270
310
22
9
5
0
185
178
4
4
−2
1
303
318
5
21
1
1
29
21
14
13
5
1
80
73
7


12
−2
0
175
180
4
11
5
0
11
51
10
6
−2
1
476
490
11
−26
2
1
48
58
21
15
5
1
113
110
8


14
−2
0
64
62
6
13
5
0
111
93
6
8
−2
1
529
557
37
−24
2
1
100
102
10
17
5
1
60
81
10


16
−2
0
136
130
10
15
5
0
27
21
27
10
−2
1
459
504
30
−22
2
1
219
218
9
19
5
1
34
60
21


18
−2
0
192
198
5
17
5
0
28
45
28
12
−2
1
124
130
4
−20
2
1
199
190
7
−16
6
1
10
23
10


20
−2
0
112
102
6
19
5
0
22
27
21
14
−2
1
104
89
6
−18
2
1
63
52
11
−14
6
1
0
20
1


22
−2
0
62
77
17
4
6
0
47
57
11
16
−2
1
290
278
7
−16
2
1
215
194
6
−12
6
1
61
61
10


24
−2
0
119
145
6
6
6
0
57
56
6
18
−2
1
393
384
7
−10
2
1
436
431
14
−10
6
1
28
39
24


26
−2
0
0
38
1
8
6
0
47
52
8
20
−2
1
106
120
21
−8
2
1
134
159
7
−8
6
1
71
79
6


1
−1
0
1074
1170
22
10
6
0
22
12
22
22
−2
1
167
142
11
−6
2
1
252
250
9
−6
6
1
34
39
10


3
−1
0
1769
1951
39
12
6
0
45
37
14
24
−2
1
34
23
20
−2
2
1
249
257
4
−4
6
1
25
26
25


5
−1
0
1600
1755
36
14
6
0
0
24
1
26
−2
1
40
37
23
0
2
1
730
762
10
4
6
1
36
35
9


7
−1
0
967
1006
20
16
6
0
16
6
16
−27
−1
1
0
7
1
2
2
1
259
300
3
6
6
1
89
86
4


9
−1
0
38
38
12
−16
−6
1
27
23
26
−25
−1
1
105
98
8
4
2
1
304
317
4
8
6
1
18
31
18


11
−1
0
201
210
5
−21
−5
1
0
18
1
−23
−1
1
97
87
9
6
2
1
485
489
15
10
6
1
59
78
8


13
−1
0
262
261
6
−19
−5
1
18
35
18
−21
−1
1
349
352
6
8
2
1
556
557
17
12
6
1
24
10
23


15
−1
0
273
271
4
−17
−5
1
95
86
9
−19
−1
1
221
214
4
10
2
1
488
503
15
14
6
1
11
30
10


17
−1
0
232
224
4
−15
−5
1
135
128
8
−17
−1
1
204
193
4
12
2
1
134
129
7
−16
−6
2
14
13
14


19
−1
0
311
304
5
−13
−5
1
142
146
8
−15
−1
1
141
143
4
14
2
1
103
90
10
−21
−5
2
75
53
10


21
−1
0
44
41
14
−11
−5
1
131
124
8
−13
−1
1
460
413
9
16
2
1
285
278
10
−19
−5
2
91
90
9


23
−1
0
87
76
10
−9
−5
1
18
25
17
−11
−1
1
909
940
16
20
2
1
108
121
10
−17
−5
2
65
78
12


25
−1
0
46
45
15
9
−5
1
91
108
9
−9
−1
1
402
390
10
22
2
1
166
143
9
−15
−5
2
52
57
17


27
−1
0
43
50
13
11
−5
1
111
133
8
−7
−1
1
583
602
10
24
2
1
0
23
1
−13
−5
2
12
15
12


2
0
0
312
362
4
13
−5
1
54
73
16
−5
−1
1
1075
1157
19
−25
3
1
54
29
18
−11
−5
2
117
119
8


4
0
0
117
119
3
15
−5
1
101
110
9
−3
−1
1
951
1044
21
−23
3
1
33
20
33
−9
−5
2
172
180
7


6
0
0
308
322
5
17
−5
1
83
80
10
−1
−1
1
1322
1398
27
−21
3
1
61
41
17
9
−5
2
129
118
8


8
0
0
345
323
7
19
−5
1
53
60
14
1
−1
1
1140
1212
19
−19
3
1
76
86
13
11
−5
2
50
32
17


10
0
0
1081
1115
28
−22
−4
1
71
87
11
3
−1
1
404
455
7
−17
3
1
91
102
8
13
−5
2
0
33
1


12
0
0
621
642
13
−20
−4
1
69
76
12
5
−1
1
507
544
8
−15
3
1
170
173
11
15
−5
2
47
32
19


14
0
0
51
44
8
−18
−4
1
42
63
20
7
−1
1
560
600
9
−13
3
1
178
175
5
17
−5
2
44
48
19


16
0
0
42
40
9
−16
−4
1
115
100
9
9
−1
1
317
313
9
−11
3
1
114
118
4
19
−5
2
56
50
12


18
0
0
50
53
11
−14
−4
1
69
57
10
11
−1
1
182
183
5
−9
3
1
231
218
6
−24
−4
2
35
14
35


20
0
0
34
31
19
−12
−4
1
137
117
6
13
−1
1
376
360
8
−7
3
1
194
198
8
−22
−4
2
0
17
1


22
0
0
92
81
7
−10
−4
1
196
179
6
15
−1
1
417
413
6
−5
3
1
337
326
8
−20
−4
2
32
23
31


24
0
0
53
52
8
−8
−4
1
102
99
5
17
−1
1
51
47
7
−3
3
1
592
563
9
−18
−4
2
66
74
12


26
0
0
14
7
13
−6
−4
1
289
284
6
19
−1
1
164
160
4
−1
3
1
479
464
8
−16
−4
2
41
34
29


1
1
0
1075
1172
16
−4
−4
1
202
211
8
21
−1
1
28
21
27
1
3
1
607
614
11
−14
−4
2
46
36
14


3
1
0
1834
1949
56
4
−4
1
231
239
9
23
−1
1
147
117
8
3
3
1
288
285
5
−12
−4
2
104
94
7


5
1
0
1647
1755
25
6
−4
1
45
49
13
25
−1
1
63
65
29
5
3
1
253
265
9
−10
−4
2
106
95
10


7
1
0
952
1005
15
8
−4
1
70
55
8
−26
0
1
78
77
5
7
3
1
236
223
9
−8
−4
2
108
97
5


9
1
0
36
38
4
10
−4
1
77
74
8
−24
0
1
0
12
1
9
3
1
235
236
6
−6
−4
2
0
26
1


11
1
0
199
210
5
12
−4
1
105
91
7
−22
0
1
105
94
20
11
3
1
118
108
6
−4
−4
2
377
362
13


13
1
0
238
260
9
14
−4
1
174
156
7
−20
0
1
190
175
5
13
3
1
145
144
8
4
−4
2
102
107
8


15
1
0
271
271
4
16
−4
1
144
138
8
−18
0
1
383
366
8
17
3
1
179
169
8
6
−4
2
131
103
5


17
1
0
233
224
4
18
−4
1
110
114
9
−16
0
1
54
57
6
19
3
1
49
50
22
8
−4
2
61
56
11


19
1
0
309
304
4
20
−4
1
28
31
27
−14
0
1
770
744
17
21
3
1
69
59
15
10
−4
2
251
255
6


21
1
0
41
40
9
22
−4
1
23
11
23
−12
0
1
19
32
19
23
3
1
74
46
13
12
−4
2
140
125
7


23
1
0
55
76
19
−25
−3
1
0
29
1
−10
0
1
575
593
17
−22
4
1
61
88
16
14
−4
2
27
33
27


0
2
0
1283
1369
22
−23
−3
1
26
19
26
−8
0
1
543
599
9
−20
4
1
66
75
14
16
−4
2
42
13
25


2
2
0
371
406
6
−21
−3
1
43
42
27
−6
0
1
2059
2218
45
−18
4
1
47
64
21
18
−4
2
114
132
8


4
2
0
102
94
6
−19
−3
1
100
87
10
−4
0
1
1538
1686
33
−16
4
1
112
100
10
20
−4
2
38
58
32


6
2
0
233
223
8
−17
−3
1
104
102
7
−2
0
1
417
443
8
−14
4
1
59
56
8
22
−4
2
20
19
19


−25
−3
2
0
15
1
−8
0
2
909
967
21
21
3
2
55
56
18
18
−4
3
74
77
12
−14
0
3
214
230
4


−23
−3
2
48
24
20
−6
0
2
2200
2323
38
23
3
2
34
45
33
20
−4
3
38
25
30
−12
0
3
313
309
6


−21
−3
2
86
93
11
−4
0
2
598
601
9
−24
4
2
41
14
31
−25
−3
3
61
63
9
−10
0
3
360
335
5


−19
−3
2
103
110
10
−2
0
2
670
726
10
−22
4
2
0
17
1
−23
−3
3
0
35
1
−8
0
3
1125
1138
19


−17
−3
2
153
146
7
0
0
2
1279
1357
22
−20
4
2
12
22
12
−21
−3
3
58
53
15
−6
0
3
1022
1054
15


−15
−3
2
90
80
7
2
0
2
585
617
9
−18
4
2
74
74
13
−19
−3
3
121
114
9
−4
0
3
227
229
3


−13
−3
2
162
158
5
4
0
2
1340
1409
20
−16
4
2
7
34
6
−17
−3
3
161
151
6
−2
0
3
1111
1236
17


−11
−3
2
334
343
8
6
0
2
1056
1084
16
−14
4
2
33
36
17
−15
−3
3
86
82
7
0
0
3
744
848
11


−9
−3
2
201
191
8
8
0
2
23
31
12
−12
4
2
97
94
5
−13
−3
3
237
228
8
2
0
3
1244
1255
19


−7
−3
2
764
740
23
10
0
2
71
61
5
−10
4
2
103
95
4
−11
−3
3
372
350
8
4
0
3
222
277
4


−5
−3
2
714
680
21
12
0
2
520
511
17
−8
4
2
103
96
4
−9
−3
3
362
315
12
6
0
3
9
2
9


−3
−3
2
541
545
16
14
0
2
357
365
6
−6
4
2
21
26
21
−7
−3
3
340
301
10
8
0
3
318
290
6


−1
−3
2
523
549
11
16
0
2
302
295
5
−4
4
2
396
362
7
−5
−3
3
219
236
8
10
0
3
872
844
15


1
−3
2
179
169
4
18
0
2
68
57
17
−2
4
2
234
231
2
−3
−3
3
314
326
10
12
0
3
65
71
6


3
−3
2
384
372
12
20
0
2
168
173
6
0
4
2
161
158
2
−1
−3
3
474
491
10
14
0
3
168
161
3


5
−3
2
543
516
16
22
0
2
53
44
11
2
4
2
397
387
4
1
−3
3
248
236
6
16
0
3
48
11
8


7
−3
2
195
188
8
24
0
2
16
38
16
12
4
2
133
125
5
3
−3
3
46
52
15
18
0
3
169
177
6


9
−3
2
108
87
8
−23
1
2
123
155
9
14
4
2
28
33
27
5
−3
3
100
106
8
20
0
3
221
221
6


11
−3
2
224
226
6
−21
1
2
188
174
3
16
4
2
33
13
33
7
−3
3
217
212
8
22
0
3
36
17
31


13
−3
2
226
210
6
−19
1
2
0
19
1
18
4
2
138
132
8
9
−3
3
76
67
7
24
0
3
25
18
24


15
−3
2
175
163
7
−17
1
2
104
86
4
20
4
2
36
58
36
11
−3
3
294
298
7
−23
1
3
63
63
6


17
−3
2
128
115
9
−15
1
2
76
74
6
22
4
2
0
19
1
13
−3
3
120
114
8
−21
1
3
80
78
4


19
−3
2
101
124
10
−13
1
2
352
405
16
−21
5
2
62
53
14
15
−3
3
193
170
7
−19
1
3
50
44
5


21
−3
2
68
56
13
−11
1
2
792
818
18
−19
5
2
68
90
26
17
−3
3
171
195
8
−17
1
3
71
67
3


23
−3
2
0
45
1
−9
1
2
323
318
6
−17
5
2
68
78
10
19
−3
3
76
77
12
−15
1
3
217
211
4


−26
−2
2
35
60
28
−7
1
2
290
295
4
−15
5
2
58
57
10
21
−3
3
115
109
8
−13
1
3
307
277
7


−24
−2
2
90
122
17
−5
1
2
682
732
10
−13
5
2
0
15
1
23
−3
3
20
22
20
−11
1
3
395
389
6


−22
−2
2
111
113
16
−3
1
2
685
708
9
−11
5
2
127
118
11
−28
−2
3
58
55
14
−9
1
3
190
197
3


−20
−2
2
62
31
9
−1
1
2
210
235
3
−9
5
2
183
181
6
−26
−2
3
69
81
8
−7
1
3
514
543
7


−18
−2
2
131
131
6
1
1
2
806
847
11
−7
5
2
184
179
4
−24
−2
3
69
79
15
−5
1
3
649
696
9


−16
−2
2
110
115
5
3
1
2
743
795
10
−5
5
2
148
138
4
−22
−2
3
118
94
8
−3
1
3
1714
1799
23


−14
−2
2
240
231
5
5
1
2
483
506
6
−3
5
2
36
37
8
−20
−2
3
92
70
5
−1
1
3
829
881
14


−12
−2
2
406
382
9
7
1
2
514
546
7
−1
5
2
107
103
3
−18
−2
3
127
115
5
1
1
3
235
237
3


−10
−2
2
337
359
10
9
1
2
149
155
4
1
5
2
113
118
3
−16
−2
3
179
174
5
3
1
3
94
86
2


−8
−2
2
281
276
13
11
1
2
362
383
14
3
5
2
74
75
5
−14
−2
3
138
124
8
5
1
3
248
228
3


−6
−2
2
363
343
8
13
1
2
270
290
5
5
5
2
110
102
4
−12
−2
3
102
96
6
7
1
3
129
129
4


−4
−2
2
155
160
3
15
1
2
173
162
3
7
5
2
26
51
26
−10
−2
3
793
938
23
9
1
3
318
343
8


−2
−2
2
350
360
7
17
1
2
262
253
4
9
5
2
139
118
5
−8
−2
3
395
397
28
11
1
3
117
105
4


0
−2
2
328
334
7
19
1
2
391
384
6
11
5
2
10
32
10
−6
−2
3
152
167
5
13
1
3
224
221
4


2
−2
2
403
425
7
21
1
2
50
46
9
13
5
2
0
32
1
−4
−2
3
181
173
4
15
1
3
287
269
4


4
−2
2
235
216
4
−26
2
2
49
60
21
15
5
2
40
32
16
−2
−2
3
452
478
9
17
1
3
62
56
6


6
−2
2
329
334
6
−24
2
2
102
122
10
17
5
2
44
48
25
0
−2
3
283
274
6
19
1
3
94
97
5


8
−2
2
252
273
18
−22
2
2
114
114
10
19
5
2
36
50
35
2
−2
3
410
412
15
21
1
3
104
107
4


10
−2
2
258
257
7
−20
2
2
50
32
17
−16
6
2
2
13
1
4
−2
3
179
185
4
−26
2
3
81
81
12


12
−2
2
344
339
6
−18
2
2
125
131
6
−14
6
2
38
36
19
6
−2
3
41
45
6
−24
2
3
61
79
17


14
−2
2
180
174
6
−16
2
2
110
115
6
−12
6
2
33
28
32
8
−2
3
394
395
24
−22
2
3
112
95
10


16
−2
2
112
102
7
−14
2
2
236
231
6
−10
6
2
0
21
1
10
−2
3
170
167
4
−20
2
3
87
71
16


18
−2
2
146
142
13
−12
2
2
396
381
9
−8
6
2
0
35
1
12
−2
3
223
212
6
−18
2
3
126
115
7


20
−2
2
131
147
14
−10
2
2
311
361
19
−6
6
2
17
41
17
14
−2
3
50
42
13
−16
2
3
182
174
5


22
−2
2
48
43
12
−8
2
2
281
274
16
−4
6
2
15
19
15
16
−2
3
126
142
7
−14
2
3
137
124
12


24
−2
2
40
38
17
−6
2
2
369
342
8
4
6
2
43
48
6
18
−2
3
140
136
10
−12
2
3
99
96
9


−27
−1
2
57
64
23
−4
2
2
167
160
4
6
6
2
50
51
7
20
−2
3
140
155
12
−10
2
3
767
938
24


−25
−1
2
83
70
10
−2
2
2
347
358
4
8
6
2
38
29
11
22
−2
3
32
51
32
−8
2
3
402
398
22


−23
−1
2
120
155
5
0
2
2
321
335
4
10
6
2
20
20
20
24
−2
3
50
47
11
−6
2
3
153
167
6


−21
−1
2
192
174
5
2
2
2
413
426
5
12
6
2
0
18
1
−27
−1
3
130
110
6
−4
2
3
183
171
3


−19
−1
2
0
18
1
4
2
2
233
215
3
14
6
2
48
38
12
−25
−1
3
27
15
26
−2
2
3
441
477
5


−17
−1
2
97
87
4
6
2
2
327
334
5
−16
−6
3
45
20
15
−23
−1
3
38
63
16
0
2
3
273
276
3


−15
−1
2
65
74
5
8
2
2
271
272
7
−21
−5
3
52
18
13
−21
−1
3
73
78
6
2
2
3
406
413
5


−13
−1
2
370
405
6
10
2
2
259
257
5
−19
−5
3
45
44
18
−19
−1
3
36
44
11
4
2
3
172
185
3


−11
−1
2
813
818
14
12
2
2
346
340
4
−17
−5
3
0
30
1
−17
−1
3
72
66
4
6
2
3
40
45
5


−9
−1
2
325
320
6
14
2
2
178
174
3
−15
−5
3
33
58
32
−15
−1
3
217
211
6
8
2
3
394
394
9


−7
−1
2
288
296
5
16
2
2
93
102
11
−13
−5
3
122
154
8
−13
−1
3
323
277
6
10
2
3
172
166
4


−5
−1
2
685
732
12
20
2
2
126
147
9
−11
−5
3
102
105
8
−11
−1
3
412
390
8
12
2
3
223
211
3


−3
−1
2
654
708
12
22
2
2
15
42
14
−9
−5
3
20
16
20
−9
−1
3
186
196
4
14
2
3
51
42
4


−1
−1
2
205
233
4
24
2
2
6
38
6
9
−5
3
157
156
8
−7
−1
3
530
541
9
16
2
3
127
142
9


1
−1
2
815
849
15
−25
3
2
22
15
22
11
−5
3
66
56
13
−5
−1
3
661
696
11
20
2
3
127
155
9


3
−1
2
759
794
13
−23
3
2
27
24
26
13
−5
3
148
141
8
−3
−1
3
1674
1797
32
22
2
3
47
51
20


5
−1
2
492
505
8
−21
3
2
90
93
12
15
−5
3
50
53
16
−1
−1
3
809
881
14
24
2
3
33
47
33


7
−1
2
522
546
14
−19
3
2
96
109
11
17
−5
3
44
50
19
1
−1
3
231
236
4
−25
3
3
38
63
38


9
−1
2
162
156
4
−17
3
2
143
147
12
−24
−4
3
33
12
33
3
−1
3
93
86
4
−23
3
3
32
35
32


11
−1
2
381
386
6
−15
3
2
84
80
13
−22
−4
3
54
32
16
5
−1
3
244
228
5
−21
3
3
45
53
29


13
−1
2
274
291
6
−13
3
2
159
158
6
−20
−4
3
0
28
1
7
−1
3
130
129
5
−19
3
3
103
113
11


15
−1
2
172
162
4
−11
3
2
326
343
6
−18
−4
3
60
46
13
9
−1
3
338
343
6
−17
3
3
161
152
6


17
−1
2
270
253
4
−9
3
2
197
189
6
−16
−4
3
64
78
13
11
−1
3
125
105
4
−15
3
3
76
82
7


19
−1
2
388
384
6
−7
3
2
768
740
17
−14
−4
3
0
21
1
13
−1
3
219
221
4
−13
3
3
224
227
5


21
−1
2
23
45
22
−5
3
2
706
681
15
−12
−4
3
104
106
6
15
−1
3
284
270
5
−11
3
3
360
350
7


23
−1
2
87
76
10
−3
3
2
545
546
9
−10
−4
3
175
167
5
17
−1
3
55
57
8
−9
3
3
366
316
8


25
−1
2
17
14
16
−1
3
2
519
550
17
−8
−4
3
148
135
5
19
−1
3
95
97
9
−7
3
3
330
302
8


−26
0
2
43
34
9
1
3
2
166
172
4
−6
−4
3
121
119
5
21
−1
3
106
107
11
−5
3
3
220
237
6


−24
0
2
135
129
6
3
3
2
384
371
7
−4
−4
3
164
143
7
23
−1
3
69
65
12
−3
3
3
324
326
6


−22
0
2
41
49
41
5
3
2
521
517
18
4
−4
3
272
273
6
25
−1
3
57
43
10
−1
3
3
481
492
14


−20
0
2
76
62
5
7
3
2
185
188
9
6
−4
3
61
56
20
−26
0
3
35
27
35
1
3
3
234
237
5


−18
0
2
115
91
6
9
3
2
106
87
7
8
−4
3
156
171
6
−24
0
3
47
44
12
3
3
3
46
53
4


−16
0
2
174
176
3
11
3
2
224
226
6
10
−4
3
35
31
25
−22
0
3
0
6
1
5
3
3
102
106
4


−14
0
2
213
236
4
13
3
2
228
210
8
12
−4
3
158
156
13
−20
0
3
15
9
14
7
3
3
218
211
8


−12
0
2
266
266
5
17
3
2
122
115
10
14
−4
3
202
205
8
−18
0
3
87
83
4
9
3
3
77
68
6


−10
0
2
881
931
13
19
3
2
96
124
10
16
−4
3
189
196
8
−16
0
3
138
114
3
11
3
3
307
298
9


13
3
3
114
114
10
14
−4
4
93
77
11
−16
0
4
117
118
5
9
3
4
99
99
7
−27
−3
5
86
76
6


15
3
3
201
169
9
16
−4
4
15
35
14
−14
0
4
261
256
5
11
3
4
102
107
10
−25
−3
5
88
76
7


19
3
3
81
77
12
18
−4
4
54
51
16
−12
0
4
547
540
9
13
3
4
108
96
10
−23
−3
5
0
23
1


21
3
3
80
109
12
20
−4
4
18
35
18
−10
0
4
24
15
13
15
3
4
227
228
9
−21
−3
5
30
18
30


23
3
3
35
22
35
−27
−3
4
48
39
11
−8
0
4
834
878
15
19
3
4
26
4
25
−19
−3
5
70
65
20


−24
4
3
0
12
1
−25
−3
4
20
23
19
−6
0
4
80
82
3
21
3
4
50
55
19
−17
−3
5
92
80
13


−22
4
3
31
32
31
−23
−3
4
17
31
17
−4
0
4
1279
1392
23
−24
4
4
0
32
1
−15
−3
5
69
72
8


−20
4
3
35
28
35
−21
−3
4
178
154
8
−2
0
4
315
357
5
−22
4
4
61
35
17
−13
−3
5
255
231
6


−18
4
3
56
46
18
−19
−3
4
12
2
11
0
0
4
1116
1209
17
−20
4
4
45
35
24
−11
−3
5
349
338
7


−16
4
3
57
78
17
−17
−3
4
70
77
14
2
0
4
444
445
7
−18
4
4
87
85
11
−9
−3
5
360
349
7


−14
4
3
0
21
1
−15
−3
4
139
130
5
4
0
4
135
130
3
−16
4
4
168
153
9
−7
−3
5
244
225
8


−12
4
3
101
105
5
−13
−3
4
99
104
6
6
0
4
185
185
3
−14
4
4
191
198
5
−5
−3
5
160
143
7


−10
4
3
173
168
4
−11
−3
4
284
269
6
8
0
4
770
754
13
−12
4
4
81
86
5
−3
−3
5
262
276
6


−8
4
3
140
135
4
−9
−3
4
146
162
8
10
0
4
564
516
10
−10
4
4
0
22
1
−1
−3
5
21
26
20


−6
4
3
130
119
4
−7
−3
4
237
264
9
12
0
4
199
188
3
−8
4
4
175
179
3
1
−3
5
268
280
8


−4
4
3
162
144
5
−5
−3
4
118
125
7
14
0
4
179
164
3
−6
4
4
18
22
18
3
−3
5
163
170
8


−2
4
3
164
155
2
−3
−3
4
114
105
5
16
0
4
0
9
1
−4
4
4
154
151
3
5
−3
5
105
108
6


0
4
3
80
77
2
−1
−3
4
95
83
9
18
0
4
162
146
6
−2
4
4
289
281
4
7
−3
5
89
90
14


2
4
3
208
195
3
1
−3
4
77
76
5
20
0
4
0
12
1
0
4
4
274
263
3
9
−3
5
268
270
7


4
4
3
282
272
6
3
−3
4
330
311
10
22
0
4
92
84
14
2
4
4
125
129
2
11
−3
5
258
248
7


6
4
3
73
56
6
5
−3
4
97
101
9
24
0
4
22
34
21
4
4
4
162
153
4
13
−3
5
187
182
15


8
4
3
158
172
4
7
−3
4
229
227
6
−23
1
4
0
27
1
6
4
4
80
70
6
15
−3
5
94
111
10


10
4
3
51
31
11
9
−3
4
107
98
6
−21
1
4
197
192
3
8
4
4
133
137
8
17
−3
5
23
34
22


14
4
3
199
206
8
11
−3
4
111
107
7
−19
1
4
114
104
3
10
4
4
276
267
5
19
−3
5
127
103
8


16
4
3
189
196
8
13
−3
4
112
96
7
−17
1
4
131
119
3
16
4
4
21
35
20
21
−3
5
53
43
15


18
4
3
70
76
13
15
−3
4
241
228
8
−15
1
4
67
65
4
18
4
4
72
51
12
−28
−2
5
0
17
1


20
4
3
25
26
24
17
−3
4
135
128
9
−13
1
4
189
198
5
20
4
4
60
35
14
−26
−2
5
0
10
1


−21
5
3
4
18
4
19
−3
4
0
3
1
−11
1
4
327
317
5
−21
5
4
33
25
32
−24
−2
5
77
111
7


−19
5
3
51
44
12
21
−3
4
57
55
14
−9
1
4
977
1049
13
−19
5
4
33
44
32
−22
−2
5
64
55
9


−17
5
3
36
30
36
−28
−2
4
85
98
9
−7
1
4
166
184
3
−17
5
4
93
122
18
−20
−2
5
107
100
7


−15
5
3
57
58
10
−26
−2
4
55
65
10
−5
1
4
477
502
6
−15
5
4
65
75
9
−18
−2
5
147
125
7


−13
5
3
144
154
18
−24
−2
4
77
91
7
−3
1
4
266
278
4
−13
5
4
31
42
30
−16
−2
5
89
89
6


−11
5
3
118
105
10
−22
−2
4
130
133
12
−1
1
4
991
1024
23
−11
5
4
160
169
5
−14
−2
5
325
326
6


−9
5
3
34
16
20
−20
−2
4
108
93
7
1
1
4
413
429
6
−9
5
4
117
103
6
−12
−2
5
75
82
6


−7
5
3
135
135
5
−18
−2
4
162
147
4
3
1
4
28
30
6
−7
5
4
342
333
8
−10
−2
5
328
327
12


−5
5
3
19
14
19
−16
−2
4
130
116
13
5
1
4
372
385
5
−5
5
4
198
205
5
−8
−2
5
554
568
18


−3
5
3
385
387
6
−14
−2
4
326
327
6
7
1
4
191
195
4
−3
5
4
187
183
3
−6
−2
5
424
432
7


−1
5
3
156
149
2
−12
−2
4
549
586
17
9
1
4
139
157
5
−1
5
4
28
44
5
−4
−2
5
201
208
4


1
5
3
106
105
3
−10
−2
4
84
114
16
11
1
4
342
332
4
1
5
4
36
37
8
−2
−2
5
373
376
8


3
5
3
62
54
6
−8
−2
4
215
240
21
13
1
4
229
203
4
3
5
4
144
129
4
0
−2
5
443
432
9


5
5
3
44
38
10
−6
−2
4
237
241
4
15
1
4
261
249
4
5
5
4
95
99
6
2
−2
5
369
382
8


7
5
3
140
131
5
−4
−2
4
153
148
3
17
1
4
70
53
5
7
5
4
255
244
8
4
−2
5
253
257
6


9
5
3
157
156
5
−2
−2
4
189
193
5
19
1
4
88
83
6
9
5
4
58
62
9
6
−2
5
213
203
12


11
5
3
51
55
11
0
−2
4
484
496
10
21
1
4
29
27
13
11
5
4
103
94
6
8
−2
5
270
272
9


13
5
3
145
141
5
2
−2
4
513
527
9
−26
2
4
64
65
16
13
5
4
53
46
10
10
−2
5
86
76
7


15
5
3
54
53
12
4
−2
4
413
435
7
−24
2
4
85
91
12
15
5
4
26
23
25
12
−2
5
29
27
29


17
5
3
49
50
14
6
−2
4
267
255
6
−22
2
4
126
133
10
17
5
4
0
19
1
14
−2
5
79
83
9


−16
6
3
0
20
1
8
−2
4
172
159
9
−20
2
4
103
93
8
−16
6
4
20
8
20
16
−2
5
25
15
24


−14
6
3
31
25
31
10
−2
4
178
182
5
−18
2
4
161
148
6
−14
6
4
0
15
1
18
−2
5
163
142
8


−12
6
3
0
11
1
12
−2
4
309
321
7
−16
2
4
128
116
5
−12
6
4
73
60
15
20
−2
5
56
50
29


−10
6
3
32
31
17
14
−2
4
106
113
13
−14
2
4
315
327
7
−10
6
4
132
133
5
22
−2
5
0
9
1


−8
6
3
41
44
9
16
−2
4
68
70
20
−12
2
4
567
585
36
−8
6
4
76
71
5
−29
−1
5
50
50
8


−6
6
3
128
137
5
18
−2
4
2
25
2
−10
2
4
84
116
15
−6
6
4
130
130
7
−27
−1
5
74
83
8


4
6
3
113
116
3
20
−2
4
56
59
11
−8
2
4
226
241
8
4
6
4
71
75
4
−25
−1
5
87
70
10


6
6
3
64
57
5
22
−2
4
46
64
21
−6
2
4
240
241
3
6
6
4
86
85
4
−23
−1
5
45
63
44


8
6
3
48
53
10
−29
−1
4
71
74
5
−4
2
4
150
149
2
8
6
4
0
28
1
−21
−1
5
69
77
6


10
6
3
29
38
23
−27
−1
4
34
38
34
−2
2
4
187
194
3
10
6
4
17
30
17
−19
−1
5
163
159
4


12
6
3
0
5
1
−25
−1
4
25
28
24
0
2
4
479
497
6
12
6
4
33
61
22
−17
−1
5
180
172
3


14
6
3
33
46
20
−23
−1
4
29
27
28
2
2
4
522
527
8
−21
−5
5
38
51
23
−15
−1
5
35
26
14


−16
−6
4
0
8
1
−21
−1
4
195
193
4
4
2
4
420
436
6
−19
−5
5
56
72
13
−13
−1
5
311
262
6


−21
−5
4
5
25
4
−19
−1
4
126
104
4
6
2
4
265
255
7
−17
−5
5
78
76
11
−11
−1
5
411
422
7


−19
−5
4
24
44
23
−17
−1
4
130
119
3
8
2
4
164
158
4
−15
−5
5
144
127
8
−9
−1
5
300
317
5


−17
−5
4
122
122
8
−15
−1
4
59
65
8
10
2
4
176
183
3
−13
−5
5
81
78
10
−7
−1
5
442
458
8


−15
−5
4
68
75
11
−13
−1
4
194
198
4
12
2
4
316
321
4
−11
−5
5
199
193
8
−5
−1
5
539
543
9


−13
−5
4
50
42
17
−11
−1
4
328
315
6
14
2
4
119
112
3
7
−5
5
83
99
10
−3
−1
5
393
406
6


−11
−5
4
171
169
7
−9
−1
4
1002
1049
17
16
2
4
67
71
6
9
−5
5
50
46
17
−1
−1
5
451
460
7


9
−5
4
74
62
11
−7
−1
4
174
185
5
18
2
4
0
25
1
11
−5
5
0
35
1
1
−1
5
188
199
3


11
−5
4
98
93
9
−5
−1
4
484
501
8
20
2
4
47
59
23
13
−5
5
0
14
1
3
−1
5
280
296
8


13
−5
4
0
46
1
−3
−1
4
268
279
5
22
2
4
48
64
19
15
−5
5
31
55
31
5
−1
5
218
233
10


15
−5
4
23
23
23
−1
−1
4
958
1024
15
−27
3
4
44
39
22
−24
−4
5
48
61
17
7
−1
5
264
257
11


17
−5
4
11
19
11
1
−1
4
393
426
7
−25
3
4
42
23
39
−22
−4
5
103
87
9
9
−1
5
637
624
10


−24
−4
4
46
32
18
3
−1
4
20
27
19
−23
3
4
37
31
36
−20
−4
5
91
113
9
11
−1
5
206
201
4


−22
−4
4
45
35
20
5
−1
4
395
387
8
−21
3
4
161
155
9
−18
−4
5
25
30
24
13
−1
5
156
142
4


−20
−4
4
0
36
1
7
−1
4
188
195
4
−19
3
4
0
3
1
−16
−4
5
69
41
12
15
−1
5
115
110
5


−18
−4
4
70
86
11
9
−1
4
141
156
4
−17
3
4
72
77
16
−14
−4
5
80
63
8
17
−1
5
52
55
10


−16
−4
4
156
153
8
11
−1
4
335
333
5
−15
3
4
141
130
6
−12
−4
5
224
209
6
19
−1
5
163
161
8


−14
−4
4
205
198
6
13
−1
4
221
205
4
−13
3
4
92
103
5
−10
−4
5
282
270
6
21
−1
5
0
9
1


−12
−4
4
94
86
7
15
−1
4
258
249
5
−11
3
4
274
269
5
−8
−4
5
205
205
5
23
−1
5
0
18
1


−10
−4
4
23
22
23
17
−1
4
50
52
10
−9
3
4
166
162
5
−6
−4
5
61
57
18
−26
0
5
67
70
8


−8
−4
4
167
179
5
19
−1
4
92
83
7
−7
3
4
246
263
6
4
−4
5
69
74
8
−24
0
5
117
132
6


−6
−4
4
44
22
10
21
−1
4
0
27
1
−5
3
4
119
125
3
6
−4
5
265
270
6
−22
0
5
17
41
17


−4
−4
4
143
151
7
23
−1
4
79
61
10
−3
3
4
110
105
3
8
−4
5
327
322
10
−20
0
5
43
46
11


4
−4
4
157
154
5
−26
0
4
0
13
1
−1
3
4
82
84
6
10
−4
5
294
307
7
−18
0
5
103
112
4


6
−4
4
76
70
7
−24
0
4
118
108
11
1
3
4
77
77
3
12
−4
5
82
68
12
−16
0
5
158
157
3


8
−4
4
138
138
6
−22
0
4
49
47
10
3
3
4
327
311
6
14
−4
5
17
35
17
−14
0
5
248
236
5


10
−4
4
261
266
7
−20
0
4
170
168
4
5
3
4
99
102
2
16
−4
5
65
39
14
−12
0
5
325
311
6


12
−4
4
398
404
12
−18
0
4
248
225
4
7
3
4
232
227
5
18
−4
5
61
69
13
−10
0
5
153
155
4


−8
0
5
322
330
5
21
3
5
45
43
21
−13
−3
6
208
190
5
10
0
6
90
96
4
−4
4
6
81
81
3


−6
0
5
128
120
3
−24
4
5
57
61
17
−11
−3
6
259
234
6
12
0
6
215
207
3
−2
4
6
286
261
3


−4
0
5
496
544
7
−22
4
5
114
87
10
−9
−3
6
170
156
4
14
0
6
127
136
4
0
4
6
225
211
3


−2
0
5
229
251
4
−20
4
5
89
113
11
−7
−3
6
43
40
15
16
0
6
0
3
1
2
4
6
68
66
3


0
0
5
293
313
4
−18
4
5
52
30
20
−5
−3
6
104
106
7
18
0
6
14
28
13
4
4
6
202
188
3


2
0
5
228
235
4
−16
4
5
52
41
21
−3
−3
6
151
150
5
20
0
6
0
9
1
6
4
6
218
225
5


4
0
5
1383
1397
21
−14
4
5
78
64
10
−1
−3
6
260
272
6
22
0
6
28
45
22
8
4
6
214
211
6


6
0
5
710
692
13
−12
4
5
215
209
4
1
−3
6
72
76
6
−23
1
6
108
115
6
10
4
6
32
44
32


8
0
5
186
186
4
−10
4
5
279
271
5
3
−3
6
111
115
5
−21
1
6
55
63
7
12
4
6
170
155
6


10
0
5
245
213
5
−8
4
5
210
205
4
5
−3
6
136
132
7
−19
1
6
71
69
4
16
4
6
38
25
38


12
0
5
38
8
8
−6
4
5
56
57
6
7
−3
6
224
224
6
−17
1
6
31
22
9
18
4
6
57
78
13


14
0
5
160
160
3
−4
4
5
116
96
4
9
−3
6
98
87
7
−15
1
6
176
177
3
−21
5
6
17
40
16


16
0
5
153
140
7
−2
4
5
102
103
2
11
−3
6
111
98
7
−13
1
6
61
71
4
−19
5
6
57
81
10


18
0
5
187
174
8
0
4
5
136
130
2
13
−3
6
0
49
1
−11
1
6
260
281
5
−17
5
6
29
26
29


20
0
5
90
95
8
2
4
5
127
117
2
15
−3
6
31
45
31
−9
1
6
831
852
20
−15
5
6
56
68
10


22
0
5
36
49
15
4
4
5
77
74
5
17
−3
6
75
52
13
−7
1
6
476
515
7
−13
5
6
160
146
5


−23
1
5
67
63
5
6
4
5
262
270
5
19
−3
6
17
34
17
−5
1
6
482
526
7
−11
5
6
254
246
6


−21
1
5
80
77
4
8
4
5
330
323
7
−28
−2
6
122
102
8
−3
1
6
802
822
12
−9
5
6
127
123
8


−19
1
5
165
158
3
10
4
5
306
307
6
−26
−2
6
108
85
6
−1
1
6
676
668
10
−7
5
6
234
237
6


−17
1
5
180
172
3
12
4
5
87
68
8
−24
−2
6
43
65
13
1
1
6
800
784
12
−5
5
6
86
72
5


−15
1
5
33
26
9
16
4
5
23
39
22
−22
−2
6
52
41
11
3
1
6
319
330
6
−3
5
6
76
85
4


−13
1
5
302
262
7
18
4
5
31
70
30
−20
−2
6
56
41
9
5
1
6
844
811
15
−1
5
6
88
84
2


−11
1
5
401
423
6
−21
5
5
44
51
22
−18
−2
6
186
172
4
7
1
6
586
575
10
1
5
6
239
243
4


−9
1
5
300
319
7
−19
5
5
66
72
9
−16
−2
6
92
97
5
9
1
6
188
187
3
9
5
6
48
38
11


−7
1
5
442
457
6
−17
5
5
95
76
7
−14
−2
6
230
217
5
11
1
6
129
121
3
11
5
6
49
53
11


−5
1
5
523
543
7
−15
5
5
140
127
6
−12
−2
6
457
423
10
13
1
6
11
8
11
13
5
6
0
18
1


−3
1
5
406
407
7
−13
5
5
84
78
7
−10
−2
6
151
160
16
15
1
6
87
68
5
15
5
6
0
5
1


−1
1
5
458
460
9
−11
5
5
211
193
5
−8
−2
6
177
173
4
17
1
6
41
36
13
−16
6
6
98
96
8


1
1
5
190
199
4
−9
5
5
178
176
6
−6
−2
6
286
277
6
19
1
6
76
65
5
−14
6
6
71
58
10


3
1
5
287
296
4
−7
5
5
213
197
5
−4
−2
6
219
222
5
−26
2
6
78
85
13
−12
6
6
23
43
22


5
1
5
222
233
4
−5
5
5
170
157
4
−2
−2
6
573
568
12
−24
2
6
68
65
15
−10
6
6
36
49
14


7
1
5
262
258
8
−3
5
5
196
204
3
0
−2
6
251
235
6
−22
2
6
47
41
28
−8
6
6
51
52
7


9
1
5
658
623
8
−1
5
5
68
70
3
2
−2
6
271
276
6
−20
2
6
63
41
12
−6
6
6
74
81
4


11
1
5
213
201
3
1
5
5
194
195
5
4
−2
6
164
161
6
−18
2
6
186
172
6
4
6
6
69
68
4


13
1
5
150
142
3
3
5
5
168
171
4
6
−2
6
99
103
4
−16
2
6
94
97
6
6
6
6
48
47
7


15
1
5
134
110
8
5
5
5
180
172
7
8
−2
6
258
259
11
−14
2
6
232
218
6
8
6
6
42
45
10


17
1
5
51
55
9
7
5
5
89
99
8
10
−2
6
186
173
8
−12
2
6
463
422
7
10
6
6
0
18
1


19
1
5
156
161
4
9
5
5
45
46
12
12
−2
6
74
75
11
−10
2
6
162
158
4
−21
−5
7
45
59
16


21
1
5
0
9
1
11
5
5
43
35
13
14
−2
6
34
59
34
−8
2
6
182
174
3
−19
−5
7
0
18
1


−26
2
5
17
10
16
13
5
5
10
14
10
16
−2
6
0
14
1
−6
2
6
292
278
4
−17
−5
7
70
79
11


−24
2
5
84
111
12
15
5
5
27
55
26
18
−2
6
85
91
16
−4
2
6
222
222
4
−15
−5
7
30
42
30


−22
2
5
58
55
19
−16
6
5
28
37
27
20
−2
6
64
62
9
−2
2
6
572
568
9
−13
−5
7
46
38
17


−20
2
5
112
100
7
−14
6
5
65
55
11
22
−2
6
57
63
9
0
2
6
254
232
4
−11
−5
7
124
153
8


−18
2
5
147
125
13
−12
6
5
92
97
6
−29
−1
6
33
39
15
2
2
6
278
276
5
7
−5
7
101
120
9


−16
2
5
89
89
7
−10
6
5
126
138
5
−27
−1
6
48
58
19
4
2
6
175
162
3
9
−5
7
94
77
9


−14
2
5
327
326
7
−8
6
5
85
88
4
−25
−1
6
65
91
12
6
2
6
106
104
3
11
−5
7
76
56
11


−12
2
5
69
81
7
−6
6
5
84
79
4
−23
−1
6
112
115
6
8
2
6
264
259
4
13
−5
7
0
33
1


−10
2
5
342
327
6
4
6
5
29
31
11
−21
−1
6
52
62
7
10
2
6
184
173
3
−24
−4
7
51
35
15


−8
2
5
564
567
13
6
6
5
84
88
4
−19
−1
6
65
69
5
12
2
6
76
75
4
−22
−4
7
0
26
1


−6
2
5
431
432
6
8
6
5
31
25
30
−17
−1
6
41
23
8
14
2
6
59
58
5
−20
−4
7
140
138
8


−4
2
5
200
207
3
10
6
5
58
64
10
−15
−1
6
178
177
4
16
2
6
14
14
13
−18
−4
7
144
128
8


−2
2
5
379
376
6
12
6
5
34
48
18
−13
−1
6
64
72
5
18
2
6
78
91
14
−16
−4
7
53
54
16


0
2
5
450
433
9
−21
−5
6
28
40
28
−11
−1
6
266
283
5
20
2
6
60
62
14
−14
−4
7
74
87
8


2
2
5
380
381
8
−19
−5
6
58
81
13
−9
−1
6
807
851
59
22
2
6
46
63
17
−12
−4
7
41
46
15


4
2
5
261
258
5
−17
−5
6
52
25
15
−7
−1
6
497
517
19
−27
3
6
54
15
17
−10
−4
7
14
20
13


6
2
5
210
203
4
−15
−5
6
63
69
13
−5
−1
6
508
526
8
−25
3
6
52
43
22
−8
−4
7
307
323
7


8
2
5
280
272
3
−13
−5
6
148
146
8
−3
−1
6
794
821
12
−23
3
6
95
104
12
−6
−4
7
240
240
6


10
2
5
91
76
3
7
−5
6
68
67
12
−1
−1
6
662
670
10
−21
3
6
106
126
10
2
−4
7
199
192
8


12
2
5
25
27
15
9
−5
6
60
38
13
1
−1
6
768
785
13
−19
3
6
41
61
41
4
−4
7
98
107
8


14
2
5
86
83
3
11
−5
6
58
53
14
3
−1
6
317
329
14
−17
3
6
136
113
20
6
−4
7
51
59
14


16
2
5
0
15
1
13
−5
6
0
18
1
5
−1
6
834
812
18
−15
3
6
73
69
8
8
−4
7
134
157
9


18
2
5
149
143
10
15
−5
6
29
5
28
7
−1
6
585
575
10
−13
3
6
206
190
5
10
−4
7
127
127
9


20
2
5
24
50
24
−24
−4
6
52
7
15
9
−1
6
186
187
4
−11
3
6
256
234
5
12
−4
7
101
97
10


22
2
5
0
9
1
−22
−4
6
39
49
27
11
−1
6
117
122
4
−9
3
6
151
156
4
14
−4
7
66
45
14


−27
3
5
76
76
12
−20
−4
6
49
57
16
13
−1
6
19
8
18
−7
3
6
51
40
3
16
−4
7
39
48
29


−25
3
5
106
76
11
−18
−4
6
108
103
9
15
−1
6
80
68
6
−5
3
6
102
106
4
−27
−3
7
101
92
6


−23
3
5
0
23
1
−16
−4
6
204
196
8
17
−1
6
37
37
23
−3
3
6
152
150
3
−25
−3
7
124
115
8


−21
3
5
18
19
17
−14
−4
6
164
165
12
19
−1
6
61
65
24
−1
3
6
271
271
4
−23
−3
7
103
78
9


−19
3
5
72
65
19
−12
−4
6
168
157
6
21
−1
6
31
26
30
1
3
6
74
76
3
−21
−3
7
16
69
15


−17
3
5
91
80
8
−10
−4
6
141
137
5
−26
0
6
19
35
19
3
3
6
119
115
2
−19
−3
7
64
60
13


−15
3
5
61
72
9
−8
−4
6
166
176
5
−24
0
6
67
59
8
5
3
6
136
131
2
−17
−3
7
251
222
6


−13
3
5
241
230
5
−6
−4
6
149
155
5
−22
0
6
134
127
8
7
3
6
230
224
2
−15
−3
7
121
119
5


−11
3
5
338
339
6
4
−4
6
191
188
6
−20
0
6
215
205
5
9
3
6
95
87
2
−13
−3
7
85
87
6


−9
3
5
351
349
6
6
−4
6
213
225
6
−18
0
6
107
109
4
11
3
6
111
98
11
−11
−3
7
114
109
5


−7
3
5
236
224
7
8
−4
6
218
211
6
−16
0
6
221
203
4
13
3
6
48
49
26
−9
−3
7
87
92
5


−5
3
5
171
144
3
10
−4
6
53
44
19
−14
0
6
123
110
4
15
3
6
37
45
37
−7
−3
7
88
90
5


−3
3
5
257
276
4
12
−4
6
175
155
8
−12
0
6
157
171
4
19
3
6
0
34
1
−5
−3
7
173
170
8


−1
3
5
36
25
6
14
−4
6
62
67
15
−10
0
6
85
66
4
−24
4
6
32
7
32
−3
−3
7
194
205
5


1
3
5
267
280
4
16
−4
6
0
25
1
−8
0
6
341
313
7
−22
4
6
57
49
18
−1
−3
7
119
114
10


3
3
5
169
169
3
18
−4
6
57
78
14
−6
0
6
349
364
5
−20
4
6
22
57
22
1
−3
7
78
82
5


5
3
5
104
108
3
−27
−3
6
9
15
8
−4
0
6
51
72
4
−18
4
6
104
103
10
3
−3
7
64
70
11


7
3
5
97
91
2
−25
−3
6
41
43
22
−2
0
6
15
38
14
−16
4
6
208
196
8
5
−3
7
50
44
12


9
3
5
272
270
12
−23
−3
6
93
104
9
0
0
6
248
265
4
−14
4
6
154
165
9
7
−3
7
260
243
7


11
3
5
259
248
9
−21
−3
6
121
125
9
2
0
6
63
56
4
−12
4
6
168
156
5
9
−3
7
188
183
6


13
3
5
204
182
8
−19
−3
6
65
60
17
4
0
6
110
110
6
−10
4
6
142
137
4
11
−3
7
145
145
23


15
3
5
81
111
13
−17
−3
6
121
113
10
6
0
6
0
18
1
−8
4
6
168
177
4
13
−3
7
118
135
9


19
3
5
88
103
11
−15
−3
6
76
69
9
8
0
6
664
610
12
−6
4
6
170
156
4
15
−3
7
50
46
19


17
−3
7
123
94
9
−7
1
7
447
467
9
−11
5
7
161
153
5
6
−2
8
53
56
10
−14
2
8
208
200
3


19
−3
7
57
59
13
−5
1
7
433
473
9
−9
5
7
79
85
10
8
−2
8
140
123
6
−12
2
8
172
160
3


−28
−2
7
55
68
18
−3
1
7
151
169
3
−7
5
7
48
61
12
10
−2
8
88
79
8
−10
2
8
279
284
4


−26
−2
7
65
59
8
−1
1
7
652
668
10
−5
5
7
156
162
5
12
−2
8
188
159
9
−8
2
8
400
403
8


−24
−2
7
137
146
5
1
1
7
340
341
7
−3
5
7
191
183
3
14
−2
8
165
153
8
−6
2
8
238
220
4


−22
−2
7
37
29
16
3
1
7
322
323
8
−1
5
7
156
148
2
16
−2
8
81
73
8
−4
2
8
162
166
4


−20
−2
7
117
109
7
5
1
7
251
250
5
1
5
7
43
29
42
18
−2
8
0
14
1
−2
2
8
347
323
5


−18
−2
7
143
142
6
7
1
7
449
431
6
9
5
7
75
77
7
20
−2
8
36
36
15
0
2
8
118
111
4


−16
−2
7
4
37
4
9
1
7
363
359
5
11
5
7
54
56
12
−29
−1
8
55
48
9
2
2
8
220
212
3


−14
−2
7
218
201
5
11
1
7
161
155
4
13
5
7
0
33
1
−27
−1
8
39
40
17
4
2
8
159
144
3


−12
−2
7
313
294
6
13
1
7
15
28
15
−16
6
7
40
25
19
−25
−1
8
74
75
10
6
2
8
52
57
6


−10
−2
7
207
228
8
15
1
7
100
88
10
−14
6
7
45
60
15
−23
−1
8
111
127
9
8
2
8
135
123
4


−8
−2
7
181
170
5
17
1
7
78
75
5
−12
6
7
64
70
12
−21
−1
8
121
109
5
10
2
8
91
79
4


−6
−2
7
207
214
5
19
1
7
45
46
7
−10
6
7
64
75
7
−19
−1
8
85
94
4
12
2
8
175
159
5


−4
−2
7
159
173
5
−28
2
7
49
68
21
−8
6
7
25
28
24
−17
−1
8
245
242
5
14
2
8
159
153
4


−2
−2
7
217
213
5
−26
2
7
74
59
14
−6
6
7
33
33
9
−15
−1
8
97
92
4
16
2
8
56
73
21


0
−2
7
94
94
5
−24
2
7
150
146
9
4
6
7
72
75
4
−13
−1
8
282
287
5
18
2
8
0
15
1


2
−2
7
161
149
8
−22
2
7
58
29
18
6
6
7
32
39
11
−11
−1
8
127
137
7
20
2
8
17
36
17


4
−2
7
171
178
4
−20
2
7
119
110
7
8
6
7
40
45
14
−9
−1
8
758
744
16
−27
3
8
85
69
12


6
−2
7
133
130
4
−18
2
7
150
142
6
−21
−5
8
0
33
1
−7
−1
8
423
407
9
−25
3
8
99
82
11


8
−2
7
267
252
7
−16
2
7
25
37
24
−19
−5
8
46
38
17
−5
−1
8
566
606
10
−23
3
8
23
21
22


10
−2
7
76
71
11
−14
2
7
220
201
3
−17
−5
8
40
29
22
−3
−1
8
446
460
15
−21
3
8
97
95
10


12
−2
7
57
62
18
−12
2
7
311
294
4
−15
−5
8
83
89
9
−1
−1
8
382
391
7
−19
3
8
33
12
33


14
−2
7
166
122
9
−10
2
7
216
228
5
−13
−5
8
54
62
14
1
−1
8
583
575
12
−17
3
8
94
100
8


16
−2
7
115
87
7
−8
2
7
190
170
4
−11
−5
8
24
35
23
3
−1
8
143
139
4
−15
3
8
37
23
18


18
−2
7
86
116
7
−6
2
7
205
214
5
7
−5
8
94
100
9
5
−1
8
255
249
4
−13
3
8
53
50
11


20
−2
7
16
19
15
−4
2
7
156
173
3
9
−5
8
0
17
1
7
−1
8
242
234
4
−11
3
8
57
51
6


−29
−1
7
40
43
15
−2
2
7
215
213
4
11
−5
8
21
39
20
9
−1
8
45
43
8
−9
3
8
89
83
2


−27
−1
7
133
126
7
0
2
7
99
94
4
13
−5
8
0
36
1
11
−1
8
111
104
5
−7
3
8
110
114
2


−25
−1
7
57
47
14
2
2
7
161
150
3
−24
−4
8
0
31
1
13
−1
8
24
34
24
−5
3
8
59
64
4


−23
−1
7
24
15
23
4
2
7
183
178
3
−22
−4
8
105
87
9
15
−1
8
65
47
11
−3
3
8
114
115
3


−21
−1
7
50
48
7
6
2
7
132
130
3
−20
−4
8
74
90
10
17
−1
8
109
104
6
−1
3
8
124
108
2


−19
−1
7
243
229
4
8
2
7
280
253
4
−18
−4
8
58
61
14
19
−1
8
40
52
16
1
3
8
41
38
6


−17
−1
7
83
83
4
10
2
7
82
71
4
−16
−4
8
152
125
8
−28
0
8
0
12
1
3
3
8
109
105
3


−15
−1
7
96
98
4
12
2
7
62
61
6
−14
−4
8
71
68
11
−26
0
8
67
64
7
5
3
8
171
172
2


−13
−1
7
123
135
4
14
2
7
147
122
4
−12
−4
8
97
92
7
−24
0
8
110
124
6
7
3
8
116
112
3


−11
−1
7
154
161
4
16
2
7
85
88
14
−10
−4
8
225
219
6
−22
0
8
15
14
15
9
3
8
46
46
6


−9
−1
7
207
214
9
18
2
7
93
116
12
−8
−4
8
220
223
6
−20
0
8
261
264
6
11
3
8
133
140
10


−7
−1
7
474
467
9
20
2
7
0
19
1
−6
−4
8
76
71
9
−18
0
8
129
135
7
13
3
8
55
63
18


−5
−1
7
438
473
11
−27
3
7
100
92
10
2
−4
8
136
132
8
−16
0
8
30
25
9
15
3
8
67
89
16


−3
−1
7
162
170
3
−25
3
7
132
115
9
4
−4
8
141
129
6
−14
0
8
117
95
4
−24
4
8
0
31
1


−1
−1
7
648
666
10
−23
3
7
84
78
12
6
−4
8
114
116
7
−12
0
8
444
426
8
−22
4
8
98
87
11


1
−1
7
338
339
8
−21
3
7
62
69
16
8
−4
8
205
199
8
−10
0
8
42
55
8
−20
4
8
79
90
12


3
−1
7
325
324
10
−19
3
7
46
59
46
10
−4
8
53
46
19
−8
0
8
321
317
6
−18
4
8
33
60
32


5
−1
7
253
250
5
−17
3
7
251
223
7
12
−4
8
123
105
9
−6
0
8
330
316
5
−16
4
8
153
125
9


7
−1
7
446
432
7
−15
3
7
113
119
6
14
−4
8
24
25
24
−4
0
8
545
598
12
−14
4
8
67
68
8


9
−1
7
357
359
5
−13
3
7
80
88
7
16
−4
8
73
50
10
−2
0
8
7
6
6
−12
4
8
101
91
5


11
−1
7
167
153
6
−11
3
7
108
110
4
−27
−3
8
79
68
6
0
0
8
145
144
8
−10
4
8
220
219
4


13
−1
7
33
27
17
−9
3
7
89
91
2
−25
−3
8
98
82
6
2
0
8
426
432
11
−8
4
8
231
223
4


15
−1
7
78
88
8
−7
3
7
94
89
2
−23
−3
8
7
21
7
4
0
8
193
194
4
−6
4
8
70
70
3


17
−1
7
64
75
10
−5
3
7
182
170
3
−21
−3
8
73
95
11
6
0
8
224
200
3
−4
4
8
136
130
3


19
−1
7
39
46
17
−3
3
7
204
205
3
−19
−3
8
27
13
26
8
0
8
48
58
6
−2
4
8
126
114
4


21
−1
7
0
25
1
−1
3
7
130
115
2
−17
−3
8
111
100
6
10
0
8
23
7
22
0
4
8
83
83
3


−28
0
7
0
12
1
1
3
7
88
82
3
−15
−3
8
0
24
1
12
0
8
125
125
5
2
4
8
139
133
3


−26
0
7
21
36
21
3
3
7
74
70
3
−13
−3
8
36
49
16
14
0
8
80
75
6
4
4
8
141
129
3


−24
0
7
137
155
6
5
3
7
41
44
5
−11
−3
8
59
51
8
16
0
8
0
19
1
6
4
8
108
117
8


−22
0
7
36
49
15
7
3
7
264
242
3
−9
−3
8
90
83
6
18
0
8
64
77
13
8
4
8
196
199
10


−20
0
7
249
257
6
9
3
7
180
184
3
−7
−3
8
101
114
5
20
0
8
0
0
1
10
4
8
21
46
20


−18
0
7
65
51
5
11
3
7
147
144
9
−5
−3
8
56
64
7
−23
1
8
125
127
3
12
4
8
102
105
11


−16
0
7
119
96
3
13
3
7
110
135
10
−3
−3
8
111
114
12
−21
1
8
117
108
3
16
4
8
47
50
16


−14
0
7
183
188
5
15
3
7
29
46
28
−1
−3
8
106
108
4
−19
1
8
90
94
4
−21
5
8
17
33
17


−12
0
7
87
107
4
19
3
7
43
59
22
1
−3
8
46
38
11
−17
1
8
250
242
3
−19
5
8
43
39
16


−10
0
7
669
637
12
−24
4
7
39
35
39
3
−3
8
111
106
6
−15
1
8
101
92
3
−17
5
8
0
30
1


−8
0
7
247
229
4
−22
4
7
32
26
31
5
−3
8
167
173
12
−13
1
8
273
287
4
−15
5
8
81
89
9


−6
0
7
546
524
8
−20
4
7
125
137
9
7
−3
8
126
112
7
−11
1
8
128
135
5
−13
5
8
70
63
9


−4
0
7
481
488
7
−18
4
7
123
128
9
9
−3
8
6
45
5
−9
1
8
736
743
17
−11
5
8
38
34
19


−2
0
7
280
291
4
−16
4
7
22
54
21
11
−3
8
140
139
9
−7
1
8
408
404
11
−9
5
8
91
104
9


0
0
7
230
268
5
−14
4
7
88
86
6
13
−3
8
58
63
15
−5
1
8
585
605
10
−7
5
8
113
95
6


2
0
7
204
214
8
−12
4
7
52
46
8
15
−3
8
73
89
13
−3
1
8
450
459
7
−5
5
8
125
121
5


4
0
7
547
532
10
−10
4
7
0
20
1
17
−3
8
48
56
19
−1
1
8
384
391
6
−3
5
8
96
88
3


6
0
7
149
148
5
−8
4
7
310
323
5
−28
−2
8
68
90
7
1
1
8
573
575
19
−1
5
8
49
49
5


8
0
7
208
209
3
−6
4
7
246
240
5
−26
−2
8
44
47
12
3
1
8
141
138
4
11
5
8
34
39
17


10
0
7
42
42
7
−4
4
7
59
64
4
−24
−2
8
60
61
9
5
1
8
263
248
4
13
5
8
34
36
14


12
0
7
165
166
3
−2
4
7
84
69
3
−22
−2
8
69
78
9
7
1
8
243
234
3
−16
6
8
47
55
14


14
0
7
0
9
1
0
4
7
62
57
4
−20
−2
8
47
44
10
9
1
8
31
42
11
−14
6
8
12
32
11


16
0
7
149
127
10
2
4
7
215
193
3
−18
−2
8
107
99
9
11
1
8
111
104
5
−12
6
8
21
26
20


18
0
7
0
9
1
4
4
7
121
107
4
−16
−2
8
115
101
6
13
1
8
17
34
16
−10
6
8
55
54
8


20
0
7
112
104
6
6
4
7
51
58
10
−14
−2
8
207
200
5
15
1
8
49
46
11
−8
6
8
47
38
13


22
0
7
0
13
1
8
4
7
150
158
7
−12
−2
8
173
160
5
17
1
8
99
104
4
−6
6
8
54
43
4


−23
1
7
4
14
4
10
4
7
123
127
6
−10
−2
8
286
284
6
19
1
8
53
52
7
4
6
8
0
32
1


−21
1
7
47
49
6
12
4
7
75
96
9
−8
−2
8
403
403
12
−28
2
8
34
90
34
6
6
8
57
64
5


−19
1
7
240
229
3
16
4
7
40
48
23
−6
−2
8
241
221
6
−26
2
8
34
47
34
−21
−5
9
0
19
1


−17
1
7
95
82
5
−21
5
7
55
59
17
−4
−2
8
158
166
5
−24
2
8
34
61
34
−19
−5
9
0
35
1


−15
1
7
95
98
3
−19
5
7
22
18
22
−2
−2
8
349
323
9
−22
2
8
67
78
15
−17
−5
9
27
20
26


−13
1
7
113
134
4
−17
5
7
56
79
11
0
−2
8
124
110
5
−20
2
8
62
43
11
−15
−5
9
31
37
31


−11
1
7
146
161
7
−15
5
7
55
43
11
2
−2
8
221
214
5
−18
2
8
113
100
7
−13
−5
9
13
31
13


−9
1
7
212
215
5
−13
5
7
18
39
18
4
−2
8
156
145
9
−16
2
8
117
100
3
−11
−5
9
46
53
16


7
−5
9
33
40
32
11
−1
9
55
41
10
−3
3
9
71
64
3
1
−3
10
225
218
6
−9
1
10
412
408
6


9
−5
9
68
85
11
13
−1
9
107
91
9
−1
3
9
79
75
3
3
−3
10
72
84
9
−7
1
10
232
229
4


11
−5
9
104
106
7
15
−1
9
13
24
13
1
3
9
203
204
3
5
−3
10
100
96
7
−5
1
10
224
223
4


−24
−4
9
9
30
8
17
−1
9
54
49
18
3
3
9
49
45
6
7
−3
10
30
24
29
−3
1
10
289
284
5


−22
−4
9
37
27
27
19
−1
9
0
30
1
5
3
9
90
77
3
9
−3
10
109
90
10
−1
1
10
132
139
3


−20
−4
9
32
26
32
−28
0
9
24
35
23
7
3
9
44
35
7
11
−3
10
133
130
8
1
1
10
328
341
4


−18
−4
9
81
93
10
−26
0
9
49
56
13
9
3
9
166
176
6
13
−3
10
67
68
14
3
1
10
115
104
3


−16
−4
9
88
80
9
−24
0
9
29
39
29
11
3
9
88
107
12
15
−3
10
76
61
11
5
1
10
122
118
3


−14
−4
9
50
33
12
−22
0
9
207
206
5
13
3
9
16
48
16
−28
−2
10
115
97
5
7
1
10
154
136
3


−12
−4
9
246
243
8
−20
0
9
181
170
5
15
3
9
33
19
32
−26
−2
10
119
113
5
9
1
10
181
177
3


−10
−4
9
115
117
6
−18
0
9
44
50
6
−24
4
9
33
30
33
−24
−2
10
58
40
9
11
1
10
33
33
32


−8
−4
9
240
235
6
−16
0
9
98
90
3
−22
4
9
0
27
1
−22
−2
10
42
41
13
13
1
10
136
150
5


−6
−4
9
243
265
9
−14
0
9
100
101
4
−20
4
9
37
26
37
−20
−2
10
234
220
5
15
1
10
14
14
14


2
−4
9
193
182
8
−12
0
9
260
261
5
−18
4
9
95
92
11
−18
−2
10
125
126
6
17
1
10
0
17
1


4
−4
9
67
66
11
−10
0
9
641
625
11
−16
4
9
47
80
24
−16
−2
10
17
41
17
−28
2
10
100
97
11


6
−4
9
154
132
8
−8
0
9
1007
926
17
−14
4
9
24
32
24
−14
−2
10
211
200
7
−26
2
10
116
113
10


8
−4
9
132
141
9
−6
0
9
559
566
10
−12
4
9
242
243
5
−12
−2
10
28
41
25
−24
2
10
43
40
37


10
−4
9
0
9
1
−4
0
9
410
437
13
−10
4
9
130
118
4
−10
−2
10
224
228
5
−22
2
10
46
40
29


12
−4
9
71
50
13
−2
0
9
114
107
7
−8
4
9
240
235
4
−8
−2
10
207
195
4
−20
2
10
234
220
7


14
−4
9
45
51
20
0
0
9
0
13
1
−6
4
9
267
265
5
−6
−2
10
144
132
5
−18
2
10
129
127
5


−27
−3
9
27
5
26
2
0
9
142
138
5
−4
4
9
139
137
3
−4
−2
10
212
201
3
−16
2
10
33
41
11


−25
−3
9
30
51
30
4
0
9
148
158
3
−2
4
9
31
38
11
−2
−2
10
179
174
4
−14
2
10
207
200
3


−23
−3
9
77
83
11
6
0
9
371
334
5
0
4
9
84
79
3
0
−2
10
90
84
4
−12
2
10
37
42
8


−21
−3
9
90
110
9
8
0
9
10
21
9
2
4
9
184
182
3
2
−2
10
116
118
4
−10
2
10
212
228
3


−19
−3
9
47
64
18
10
0
9
40
44
9
4
4
9
77
66
3
4
−2
10
47
59
9
−8
2
10
205
194
3


−17
−3
9
92
83
12
12
0
9
41
59
10
6
4
9
141
132
6
6
−2
10
90
93
8
−6
2
10
144
133
3


−15
−3
9
109
107
11
14
0
9
0
7
1
8
4
9
134
142
9
8
−2
10
150
152
16
−4
2
10
206
200
3


−13
−3
9
74
62
12
16
0
9
57
57
17
10
4
9
26
9
25
10
−2
10
135
119
9
−2
2
10
175
174
2


−11
−3
9
129
133
12
18
0
9
14
19
14
12
4
9
43
50
32
12
−2
10
31
35
30
0
2
10
83
84
3


−9
−3
9
315
304
7
20
0
9
49
57
7
−21
5
9
29
19
28
14
−2
10
42
46
28
2
2
10
130
117
3


−7
−3
9
187
188
5
−25
1
9
103
111
11
−19
5
9
33
35
32
16
−2
10
57
68
17
4
2
10
72
60
5


−5
−3
9
155
156
5
−23
1
9
35
36
11
−17
5
9
12
20
12
−29
−1
10
107
106
5
6
2
10
101
94
5


−3
−3
9
58
65
6
−21
1
9
64
58
5
−15
5
9
47
37
14
−27
−1
10
51
44
16
8
2
10
155
151
5


−1
−3
9
73
74
6
−19
1
9
115
115
5
−13
5
9
37
31
21
−25
−1
10
82
89
9
10
2
10
117
119
8


1
−3
9
200
205
9
−17
1
9
160
150
3
−11
5
9
45
52
14
−23
−1
10
145
135
5
12
2
10
34
35
13


3
−3
9
52
46
11
−15
1
9
128
133
4
−9
5
9
8
12
7
−21
−1
10
74
83
5
14
2
10
37
46
10


5
−3
9
85
77
10
−13
1
9
91
75
4
−7
5
9
145
161
8
−19
−1
10
255
258
5
16
2
10
44
68
29


7
−3
9
52
35
15
−11
1
9
64
67
6
−5
5
9
43
41
10
−17
−1
10
148
137
4
−27
3
10
70
81
14


9
−3
9
157
175
9
−9
1
9
568
580
10
−3
5
9
105
93
3
−15
−1
10
159
160
4
−25
3
10
111
111
10


11
−3
9
100
107
10
−7
1
9
679
679
12
−1
5
9
186
186
3
−13
−1
10
218
209
4
−23
3
10
155
135
9


13
−3
9
37
48
37
−5
1
9
632
620
11
3
5
9
34
25
28
−11
−1
10
268
273
4
−21
3
10
17
43
16


15
−3
9
0
19
1
−3
1
9
291
281
5
11
5
9
84
106
6
−9
−1
10
426
409
6
−19
3
10
85
86
12


17
−3
9
16
16
16
−1
1
9
169
188
4
−16
6
9
51
50
12
−7
−1
10
234
229
5
−17
3
10
112
116
7


−28
−2
9
0
20
1
1
1
9
390
410
6
−14
6
9
44
47
11
−5
−1
10
225
224
6
−15
3
10
126
113
15


−26
−2
9
103
87
6
3
1
9
371
364
4
−12
6
9
41
33
11
−3
−1
10
291
284
7
−13
3
10
191
178
6


−24
−2
9
88
66
13
5
1
9
175
177
3
−10
6
9
35
44
10
−1
−1
10
136
139
5
−11
3
10
329
330
4


−22
−2
9
75
82
7
7
1
9
337
331
4
−8
6
9
33
46
9
1
−1
10
329
341
5
−9
3
10
198
193
3


−20
−2
9
38
33
25
9
1
9
96
107
4
4
6
9
38
49
6
3
−1
10
114
105
6
−7
3
10
221
223
3


−18
−2
9
10
21
9
11
1
9
39
41
13
6
6
9
33
41
7
5
−1
10
119
118
4
−5
3
10
125
118
3


−16
−2
9
86
88
12
13
1
9
94
91
6
−21
−5
10
0
12
1
7
−1
10
158
137
4
−3
3
10
65
50
4


−14
−2
9
134
127
5
15
1
9
38
24
15
−19
−5
10
40
28
21
9
−1
10
171
176
10
−1
3
10
141
146
3


−12
−2
9
167
164
7
17
1
9
48
49
8
−17
−5
10
0
30
1
11
−1
10
25
33
24
1
3
10
221
219
3


−10
−2
9
59
56
7
−28
2
9
16
20
16
−15
−5
10
43
30
19
13
−1
10
158
150
8
3
3
10
82
84
7


−8
−2
9
249
271
4
−26
2
9
110
87
11
−13
−5
10
42
39
20
15
−1
10
19
14
18
5
3
10
102
96
3


−6
−2
9
135
107
14
−24
2
9
56
66
20
−11
−5
10
55
57
13
17
−1
10
0
17
1
7
3
10
0
24
1


−4
−2
9
252
244
6
−22
2
9
86
82
12
7
−5
10
102
101
9
−28
0
10
128
124
6
9
3
10
92
90
4


−2
−2
9
75
75
15
−20
2
9
46
33
17
9
−5
10
59
60
12
−26
0
10
128
123
7
11
3
10
119
130
10


0
−2
9
183
180
4
−18
2
9
23
21
15
−24
−4
10
52
9
14
−24
0
10
29
34
29
13
3
10
40
68
39


2
−2
9
112
110
4
−16
2
9
95
88
3
−22
−4
10
61
55
13
−22
0
10
115
102
10
15
3
10
53
61
20


4
−2
9
123
111
5
−14
2
9
128
127
3
−20
−4
10
117
128
8
−20
0
10
251
255
8
−24
4
10
0
9
1


6
−2
9
65
80
9
−12
2
9
166
164
3
−18
−4
10
39
56
23
−18
0
10
93
80
3
−22
4
10
0
55
1


8
−2
9
188
175
6
−10
2
9
63
56
4
−16
−4
10
109
118
8
−16
0
10
73
74
4
−20
4
10
103
128
10


10
−2
9
44
42
17
−8
2
9
246
271
3
−14
−4
10
6
5
5
−14
0
10
653
620
8
−18
4
10
63
56
16


12
−2
9
143
151
9
−6
2
9
130
107
4
−12
−4
10
154
144
13
−12
0
10
173
181
5
−16
4
10
112
118
10


14
−2
9
58
49
18
−4
2
9
251
243
4
−10
−4
10
204
188
6
−10
0
10
354
302
6
−14
4
10
20
5
19


16
−2
9
40
38
19
−2
2
9
81
76
4
−8
−4
10
351
334
8
−8
0
10
264
271
5
−12
4
10
160
144
5


18
−2
9
12
28
12
0
2
9
182
180
3
−6
−4
10
268
280
9
−6
0
10
444
458
8
−10
4
10
199
187
5


−29
−1
9
41
38
40
2
2
9
114
111
2
2
−4
10
86
95
11
−4
0
10
324
302
6
−8
4
10
357
334
4


−27
−1
9
45
31
15
4
2
9
116
111
3
4
−4
10
106
102
9
−2
0
10
179
183
4
−6
4
10
281
281
3


−25
−1
9
100
111
8
6
2
9
84
80
5
6
−4
10
98
68
10
0
0
10
218
211
3
−4
4
10
108
119
5


−23
−1
9
38
36
14
8
2
9
188
175
3
8
−4
10
70
87
14
2
0
10
117
117
3
−2
4
10
114
111
3


−21
−1
9
60
57
6
10
2
9
23
42
23
10
−4
10
61
58
15
4
0
10
255
243
3
0
4
10
28
37
13


−19
−1
9
114
115
5
12
2
9
154
151
7
12
−4
10
0
22
1
6
0
10
150
160
3
2
4
10
94
94
4


−17
−1
9
162
150
3
14
2
9
65
50
6
−27
−3
10
55
81
9
8
0
10
291
283
4
4
4
10
102
102
3


−15
−1
9
133
133
3
16
2
9
19
38
18
−25
−3
10
110
111
7
10
0
10
72
90
5
6
4
10
85
68
14


−13
−1
9
86
75
4
−27
3
9
0
5
1
−23
−3
10
151
135
8
12
0
10
0
4
1
8
4
10
55
87
12


−11
−1
9
70
66
5
−25
3
9
37
51
36
−21
−3
10
0
43
1
14
0
10
57
42
8
10
4
10
23
59
23


−9
−1
9
590
580
20
−23
3
9
81
84
13
−19
−3
10
77
85
10
16
0
10
21
32
21
12
4
10
0
23
1


−7
−1
9
685
680
15
−21
3
9
78
110
12
−17
−3
10
120
116
9
18
0
10
0
16
1
−21
5
10
16
12
16


−5
−1
9
625
619
25
−19
3
9
79
64
12
−15
−3
10
129
113
11
−25
1
10
84
89
14
−19
5
10
0
28
1


−3
−1
9
286
280
7
−17
3
9
87
83
20
−13
−3
10
189
178
6
−23
1
10
148
135
9
−17
5
10
35
29
34


−1
−1
9
172
190
5
−15
3
9
103
107
8
−11
−3
10
315
330
7
−21
1
10
78
83
6
−15
5
10
48
30
14


1
−1
9
380
410
9
−13
3
9
72
62
10
−9
−3
10
195
192
5
−19
1
10
250
258
4
−13
5
10
49
39
13


3
−1
9
364
363
5
−11
3
9
122
133
2
−7
−3
10
220
223
5
−17
1
10
144
137
3
−11
5
10
73
58
8


5
−1
9
175
177
5
−9
3
9
313
303
3
−5
−3
10
113
119
5
−15
1
10
162
160
4
−9
5
10
76
81
10


7
−1
9
334
331
7
−7
3
9
195
188
3
−3
−3
10
56
50
6
−13
1
10
217
209
3
−7
5
10
93
111
15


9
−1
9
101
106
5
−5
3
9
159
156
3
−1
−3
10
133
146
5
−11
1
10
264
274
4
−5
5
10
81
92
5


−3
5
10
207
207
3
−1
−1
11
191
208
4
−9
3
11
32
36
9
−24
−2
12
0
19
1
−28
2
12
0
23
1


−1
5
10
80
78
5
1
−11
1
104
100
4
−7
3
11
70
67
4
−22
−2
12
126
119
17
−26
2
12
12
2
11


1
5
10
47
68
12
3
−1
11
135
138
4
−5
3
11
34
35
9
−20
−2
12
118
135
5
−24
2
12
50
19
24


3
5
10
59
75
12
5
−1
11
122
118
4
−3
3
11
163
159
4
−18
−2
12
231
223
8
−22
2
12
118
119
10


−14
6
10
19
13
19
7
−1
11
74
74
8
−1
3
11
62
61
5
−16
−2
12
166
161
6
−20
2
12
130
135
10


−12
6
10
38
40
11
9
−1
11
73
82
9
1
3
11
92
96
4
−14
−2
12
29
30
29
−18
2
12
225
223
4


−10
6
10
37
35
9
11
−1
11
97
104
7
3
3
11
71
71
5
−12
−2
12
19
28
19
−16
2
12
164
161
4


−8
6
10
28
34
10
13
−1
11
25
16
24
5
3
11
51
50
8
−10
−2
12
55
68
13
−14
2
12
10
30
9


−19
−5
11
0
41
1
15
−1
11
28
49
27
7
3
11
92
92
4
−8
−2
12
0
10
1
−12
2
12
27
28
25


−17
−5
11
32
28
32
17
−1
11
23
4
23
9
3
11
70
64
7
−6
−2
12
71
67
5
−10
2
12
62
67
7


−15
−5
11
45
52
17
−28
0
11
135
125
10
11
3
11
91
103
12
−4
−2
12
199
197
4
−8
2
12
17
9
16


−13
−5
11
0
22
1
−26
0
11
30
26
30
13
3
11
53
60
18
−2
−2
12
119
109
4
−6
2
12
67
68
4


−11
−5
11
41
36
20
−24
0
11
32
6
25
−24
4
11
41
57
31
0
−2
12
59
58
7
−4
2
12
196
197
3


−24
−4
11
63
57
11
−22
0
11
192
174
7
−22
4
11
25
64
25
2
−2
12
109
121
5
−2
2
12
117
110
3


−22
−4
11
53
64
15
−20
0
11
211
206
5
−20
4
11
89
73
12
4
−2
12
83
76
7
0
2
12
64
59
4


−20
−4
11
71
73
11
−18
0
11
0
5
1
−18
4
11
38
36
37
6
−2
12
162
159
8
2
2
12
122
122
5


−18
−4
11
59
37
13
−16
0
11
355
335
4
−16
4
11
12
12
12
8
−2
12
50
60
17
4
2
12
78
75
5


−16
−4
11
0
12
1
−14
0
11
128
119
3
−14
4
11
158
130
6
10
−2
12
73
78
12
6
2
12
147
160
6


−14
−4
11
130
131
8
−12
0
11
328
331
4
−12
4
11
379
361
8
12
−2
12
0
37
1
8
2
12
54
60
9


−12
−4
11
370
362
11
−10
0
11
408
371
5
−10
4
11
247
228
4
14
−2
12
22
39
21
10
2
12
71
78
6


−10
−4
11
241
227
8
−8
0
11
246
232
4
−8
4
11
39
33
7
−29
−1
12
31
37
25
12
2
12
46
38
8


−8
−4
11
45
34
29
−6
0
11
214
203
3
−6
4
11
31
17
11
−27
−1
12
84
63
9
14
2
12
26
39
26


−6
−4
11
0
17
1
−4
0
11
103
98
3
−4
4
11
151
150
4
−25
−1
12
41
42
12
−25
3
12
22
14
22


2
−4
11
197
185
8
−2
0
11
139
153
4
−2
4
11
155
159
4
−23
−1
12
91
75
6
−23
3
12
53
60
20


4
−4
11
127
121
9
0
0
11
120
99
5
0
4
11
127
116
6
−21
−1
12
224
212
5
−21
3
12
112
149
9


6
−4
11
26
27
25
2
0
11
261
259
4
2
4
11
189
186
3
−19
−1
12
145
145
6
−19
3
12
91
130
11


8
−4
11
72
68
13
4
0
11
207
203
3
4
4
11
110
120
3
−17
−1
12
102
106
9
−17
3
12
153
174
9


10
−4
11
44
54
24
6
0
11
61
64
6
6
4
11
36
26
33
−15
−1
12
272
254
5
−15
3
12
106
82
10


12
−4
11
0
65
1
8
0
11
89
95
4
8
4
11
61
68
10
−13
−1
12
141
137
3
−13
3
12
83
82
4


−27
−3
11
73
75
6
10
0
11
71
83
7
10
4
11
21
54
20
−11
−1
12
111
98
5
−11
3
12
100
96
4


−25
−3
11
46
34
11
12
0
11
0
28
1
−19
5
11
56
41
10
−9
−1
12
146
143
4
−9
3
12
175
183
3


−23
−3
11
48
28
17
14
0
11
15
10
15
−17
5
11
42
27
13
−7
−1
12
246
238
4
−7
3
12
41
51
8


−21
−3
11
53
42
13
16
0
11
42
29
26
−15
5
11
23
52
23
−5
−1
12
114
96
8
−5
3
12
67
58
5


−19
−3
11
121
123
8
−25
1
11
0
35
1
−13
5
11
0
23
1
−3
−1
12
204
217
4
−3
3
12
65
58
4


−17
−3
11
235
248
8
−23
1
11
62
69
7
−11
5
11
52
36
10
−1
−1
12
306
303
5
−1
3
12
101
101
4


−15
−3
11
246
234
6
−21
1
11
86
74
5
−9
5
11
140
118
7
1
−1
12
78
68
8
1
3
12
94
86
5


−13
−3
11
127
134
7
−19
1
11
376
361
6
−7
5
11
105
120
8
3
−1
12
108
99
6
3
3
12
211
209
6


−11
−3
11
170
161
5
−17
1
11
142
126
5
−5
5
11
67
71
8
5
−1
12
195
204
4
5
3
12
42
52
10


−9
−3
11
49
35
10
−15
1
11
192
183
3
−3
5
11
65
55
4
7
−1
12
143
140
5
7
3
12
121
116
4


−7
−3
11
70
67
8
−13
1
11
233
221
3
−1
5
11
60
57
4
9
−1
12
67
58
9
9
3
12
138
131
9


−5
−3
11
0
35
1
−11
1
11
367
356
4
1
5
11
111
120
7
11
−1
12
32
27
32
11
3
12
32
62
32


−3
−3
11
153
159
4
−9
1
11
223
236
4
3
5
11
25
52
24
13
−1
12
28
47
27
13
3
12
25
42
25


−1
−3
11
57
61
9
−7
1
11
87
91
5
−14
6
11
43
46
9
15
−1
12
10
10
10
−24
4
12
50
45
18


1
−3
11
94
96
7
−5
1
11
539
532
6
−12
6
11
45
48
8
−28
0
12
0
23
1
−22
4
12
0
29
1


3
−3
11
73
70
9
−3
1
11
165
172
3
−10
6
11
39
33
7
−26
0
12
11
36
10
−20
4
12
82
63
12


5
−3
11
70
49
13
−1
1
11
188
208
3
−8
6
11
31
22
7
−24
0
12
24
33
23
−18
4
12
114
112
10


7
−3
11
100
91
11
1
1
11
95
100
4
−19
−5
12
0
27
1
−22
0
12
0
4
1
−16
4
12
159
135
8


9
−3
11
60
64
16
3
1
11
147
138
3
−17
−5
12
42
48
19
−20
0
12
199
187
4
−14
4
12
168
153
6


11
−3
11
118
103
9
5
1
11
127
118
5
−15
−5
12
0
20
1
−18
0
12
391
374
5
−12
4
12
69
72
9


13
−3
11
53
60
17
7
1
11
73
75
5
−13
−5
12
67
78
11
−16
0
12
181
180
3
−10
4
12
125
139
9


−28
−2
11
0
23
1
9
1
11
59
82
9
−24
−4
12
53
45
13
−14
0
12
140
130
3
−8
4
12
0
23
1


−26
−2
11
46
50
12
11
1
11
103
104
18
−22
−4
12
7
29
7
−12
0
12
0
13
1
−6
4
12
92
91
4


−24
−2
11
64
66
8
13
1
11
0
16
1
−20
−4
12
70
62
11
−10
0
12
534
518
6
−4
4
12
115
128
5


−22
−2
11
73
81
18
15
1
11
39
49
27
−18
−4
12
133
112
8
−8
0
12
290
275
4
−2
4
12
111
122
6


−20
−2
11
202
218
11
17
1
11
0
4
1
−16
−4
12
154
135
8
−6
0
12
80
77
4
0
4
12
107
112
7


−18
−2
11
0
32
1
−28
2
11
40
22
39
−14
−4
12
152
153
8
−4
0
12
366
356
5
2
4
12
66
65
6


−16
−2
11
136
132
10
−26
2
11
30
50
29
−12
−4
12
54
71
15
−2
0
12
26
28
22
4
4
12
126
131
6


−14
−2
11
60
61
9
−24
2
11
84
66
13
−10
−4
12
119
139
8
0
0
12
289
286
5
6
4
12
38
17
19


−12
−2
11
146
142
6
−22
2
11
83
81
13
−8
−4
12
0
23
1
2
0
12
433
429
7
8
4
12
64
93
9


−10
−2
11
324
320
7
−20
2
11
213
218
9
−6
−4
12
109
91
8
4
0
12
41
44
10
10
4
12
36
43
35


−8
−2
11
56
66
7
−18
2
11
9
32
8
2
−4
12
52
65
19
6
0
12
0
9
1
−19
5
12
47
27
10


−6
−2
11
127
125
3
−16
2
11
138
131
4
4
−4
12
131
131
8
8
0
12
77
67
7
−17
5
12
24
48
23


−4
−2
11
87
84
4
−14
2
11
62
61
6
6
−4
12
0
17
1
10
0
12
140
128
6
−15
5
12
26
20
26


−2
−2
11
0
13
1
−12
2
11
146
142
4
8
−4
12
92
93
10
12
0
12
15
21
14
−13
5
12
88
78
6


0
−2
11
101
99
4
−10
2
11
309
321
4
10
−4
12
51
43
16
14
0
12
25
11
25
−11
5
12
36
30
27


2
−2
11
154
162
7
−8
2
11
51
65
10
−25
−3
12
0
14
1
16
0
12
37
60
18
−9
5
12
70
82
9


4
−2
11
160
154
5
−6
2
11
129
125
2
−23
−3
12
60
60
13
−25
1
12
38
42
38
−7
5
12
40
27
12


6
−2
11
160
151
8
−4
2
11
86
84
3
−21
−3
12
116
149
7
−23
1
12
80
75
6
−5
5
12
90
74
13


8
−2
11
119
108
9
−2
2
11
12
14
11
−19
−3
12
93
130
8
−21
1
12
219
212
8
−3
5
12
28
24
12


10
−2
11
26
45
25
0
2
11
97
100
3
−17
−3
12
157
174
7
−19
1
12
163
145
5
−1
5
12
108
110
9


12
−2
11
29
38
29
2
2
11
159
162
5
−15
−3
12
81
82
10
−17
1
12
111
106
4
−10
6
12
58
61
4


14
−2
11
68
57
13
4
2
11
162
154
3
−13
−3
12
68
82
33
−15
1
12
270
254
5
−17
−5
13
28
26
27


16
−2
11
35
24
18
6
2
11
155
151
6
−11
−3
12
93
97
18
−13
1
12
137
137
3
−15
−5
13
84
113
8


−29
−1
11
34
31
20
8
2
11
101
107
6
−9
−3
12
182
183
5
−11
1
12
114
98
4
−13
−5
13
43
50
16


−27
−1
11
44
46
19
10
2
11
40
45
13
−7
−3
12
42
51
14
−9
1
12
147
144
3
−22
−4
13
32
21
32


−25
−1
11
33
35
18
12
2
11
44
38
9
−5
−3
12
78
58
10
−7
1
12
235
237
3
−20
−4
13
43
46
19


−23
−1
11
55
69
9
14
2
11
57
57
18
−3
−3
12
52
57
13
−5
1
12
108
95
4
−18
−4
13
4
34
3


−21
−1
11
95
73
5
16
2
11
0
24
1
−1
−3
12
96
101
6
−3
1
12
209
216
3
−16
−4
13
71
62
11


−19
−1
11
382
362
8
−27
3
11
88
75
10
1
−3
12
115
86
10
−1
1
12
311
303
4
−14
−4
13
69
79
11


−17
−1
11
133
126
5
−25
3
11
66
34
16
3
−3
12
230
209
8
1
1
12
81
68
4
−12
−4
13
63
66
13


−15
−1
11
195
183
4
−23
3
11
0
28
1
5
−3
12
46
51
28
3
1
12
102
100
5
−10
−4
13
154
151
8


−13
−1
11
223
221
4
−21
3
11
29
42
28
7
−3
12
142
116
8
5
1
12
203
204
4
−8
−4
13
54
33
14


−11
−1
11
364
358
5
−19
3
11
123
123
9
9
−3
12
149
131
8
7
1
12
150
141
5
−6
−4
13
70
69
11


−9
−1
11
227
235
3
−17
3
11
244
248
9
11
−3
12
66
62
13
9
1
12
56
58
12
2
−4
13
140
135
8


−7
−1
11
86
90
4
−15
3
11
245
235
7
13
−3
12
11
42
11
11
1
12
30
27
30
4
−4
13
72
61
12


−5
−1
11
538
532
8
−13
3
11
139
133
4
−28
−2
12
3
23
3
13
1
12
27
47
27
6
−4
13
30
10
29


−3
−1
11
169
171
3
−11
3
11
164
161
3
−26
−2
12
24
2
24
15
1
12
0
10
1
8
−4
13
0
17
1


−25
−3
13
0
29
1
−19
1
13
302
281
5
−18
−4
14
72
68
10
−25
1
14
51
55
24
2
−4
15
71
76
11


−23
−3
13
46
52
17
−17
1
13
231
218
4
−16
−4
14
110
89
8
−23
1
14
91
88
7
4
−4
15
60
22
13


−21
−3
13
26
27
26
−15
1
13
175
166
4
−14
−4
14
40
52
23
−21
1
14
99
111
7
−23
−3
15
76
77
9


−19
−3
13
0
26
1
−13
1
13
61
54
5
−12
−4
14
128
120
8
−19
1
14
101
98
6
−21
−3
15
0
24
1


−17
−3
13
90
125
8
−11
1
13
144
149
6
−10
−4
14
40
38
25
−17
1
14
101
98
5
−19
−3
15
104
81
8


−15
−3
13
67
65
11
−9
1
13
116
115
3
−8
−4
14
101
96
9
−15
1
14
345
321
6
−17
−3
15
64
57
11


−13
−3
13
145
129
8
−7
1
13
73
63
5
−6
−4
14
21
48
21
−13
1
14
311
293
4
−15
−3
15
47
33
16


−11
−3
13
75
80
8
−5
1
13
253
244
3
2
−4
14
64
63
13
−11
1
14
96
89
5
−13
−3
15
158
138
7


−9
−3
13
0
19
1
−3
1
13
186
186
4
4
−4
14
38
31
32
−9
1
14
74
61
5
−11
−3
15
78
69
11


−7
−3
13
66
80
9
−1
1
13
28
31
16
6
−4
14
21
25
20
−7
1
14
89
92
4
−9
−3
15
65
53
14


−5
−3
13
51
43
10
1
1
13
230
220
3
−25
−3
14
29
24
29
−5
1
14
165
143
3
−7
−3
15
64
83
14


−3
−3
13
153
159
5
3
1
13
83
69
5
−23
−3
14
59
50
12
−3
1
14
160
164
8
−5
−3
15
94
100
7


−1
−3
13
101
109
6
5
1
13
220
212
7
−21
−3
14
38
45
24
−1
1
14
306
301
4
−3
−3
15
156
155
8


1
−3
13
54
31
17
7
1
13
152
152
5
−19
−3
14
57
65
12
1
1
14
367
351
5
−1
−3
15
58
65
16


3
−3
13
83
57
11
9
1
13
31
24
21
−17
−3
14
72
91
9
3
1
14
137
130
5
1
−3
15
139
141
8


5
−3
13
129
134
9
11
1
13
51
63
13
−15
−3
14
74
87
10
5
1
14
72
77
7
3
−3
15
76
60
13


7
−3
13
108
114
10
13
1
13
59
55
9
−13
−3
14
149
132
8
7
1
14
140
124
5
5
−3
15
19
15
18


9
−3
13
45
67
22
−28
2
13
0
27
1
−11
−3
14
29
27
29
9
1
14
14
31
14
7
−3
15
46
34
19


11
−3
13
44
42
20
−26
2
13
92
72
11
−9
−3
14
0
27
1
11
1
14
93
94
5
−26
−2
15
50
55
9


−28
−2
13
28
27
28
−24
2
13
57
82
18
−7
−3
14
122
116
8
−26
2
14
0
24
1
−24
−2
15
57
82
9


−26
−2
13
84
72
6
−22
2
13
50
68
22
−5
−3
14
131
128
5
−24
2
14
28
36
28
−22
−2
15
75
84
8


−24
−2
13
55
82
9
−20
2
13
169
184
5
−3
−3
14
50
38
12
−22
2
14
90
80
11
−20
−2
15
190
185
8


−22
−2
13
49
68
11
−18
2
13
62
55
7
−1
−3
14
188
163
8
−20
2
14
160
160
4
−18
−2
15
118
134
8


−20
−2
13
179
184
7
−15
2
13
38
45
12
1
−3
14
220
205
8
−18
2
14
101
94
5
−16
−2
15
80
87
9


−18
−2
13
64
54
12
−14
2
13
185
189
4
3
−3
14
195
186
7
−16
2
14
192
186
5
−14
−2
15
80
61
10


−16
−2
13
51
45
12
−12
2
13
137
126
4
5
−3
14
78
81
12
−14
2
14
112
109
4
−12
−2
15
13
51
12


−14
−2
13
194
189
18
−10
2
13
50
50
9
7
−3
14
36
38
35
−12
2
14
101
89
5
−10
−2
15
282
245
6


−12
−2
13
144
126
6
−8
2
13
103
103
5
9
−3
14
53
39
16
−10
2
14
29
39
28
−8
−2
15
128
121
11


−10
−2
13
51
50
11
−6
2
13
120
119
4
−26
−2
14
0
24
1
−8
2
14
154
147
3
−6
−2
15
163
153
5


−8
−2
13
109
102
5
−4
2
13
141
135
3
−24
−2
14
43
36
12
−6
2
14
134
135
5
−4
−2
15
113
99
7


−6
−2
13
114
118
6
−2
2
13
137
146
4
−22
−2
14
96
80
12
−4
2
14
68
77
4
−2
−2
15
80
75
8


−4
−2
13
136
134
4
0
2
13
223
219
4
−20
−2
14
173
160
7
−2
2
14
235
228
3
0
−2
15
237
237
6


−2
−2
13
130
146
7
2
2
13
117
108
5
−18
−2
14
107
94
8
0
2
14
110
113
6
2
−2
15
21
34
21


0
−2
13
215
219
4
4
2
13
86
93
6
−14
−2
14
118
109
18
2
2
14
85
87
6
4
−2
15
0
43
1


2
−2
13
120
108
5
6
2
13
64
80
9
−12
−2
14
104
90
7
4
2
14
100
95
5
6
−2
15
55
35
15


4
−2
13
88
93
7
8
2
13
116
124
9
−10
−2
14
44
39
16
6
2
14
90
84
20
8
−2
15
33
30
32


6
−2
13
70
80
12
10
2
13
69
73
6
−8
−2
14
150
147
4
8
2
14
64
66
8
−27
−1
15
41
40
22


8
−2
13
99
125
10
12
2
13
28
24
13
−6
−2
14
131
136
5
10
2
14
69
77
5
−25
−1
15
38
40
14


10
−2
13
50
73
20
−25
3
13
35
29
34
−4
−2
14
78
77
6
−25
3
14
44
24
20
−23
−1
15
27
26
27


12
−2
13
19
24
18
−23
3
13
42
52
29
−2
−2
14
236
228
4
−23
3
14
48
50
19
−21
−1
15
47
40
11


−29
−1
13
70
55
9
−21
3
13
0
27
1
0
−2
14
125
113
6
−21
3
14
46
45
20
−19
−1
15
81
95
7


−27
−1
13
8
35
8
−19
3
13
29
25
28
2
−2
14
97
87
7
−19
3
14
67
66
12
−17
−1
15
272
248
6


−25
−1
13
24
36
23
−17
3
13
103
125
9
4
−2
14
83
95
7
−17
3
14
85
91
10
−15
−1
15
55
47
9


−23
−1
13
65
64
7
−15
3
13
66
65
15
6
−2
14
56
84
14
−15
3
14
81
87
7
−13
−1
15
150
151
9


−21
−1
13
72
70
7
−13
3
13
136
130
6
8
−2
14
59
66
15
−13
3
14
148
132
10
−11
−1
15
6
40
6


−19
−1
13
312
281
6
−11
3
13
87
80
4
10
−2
14
92
77
9
−11
3
14
33
27
15
−9
−1
15
30
21
19


−17
−1
13
234
218
4
−9
3
13
24
20
23
−27
−1
14
26
25
26
−9
3
14
0
28
1
−7
−1
15
98
105
11


−15
−1
13
173
166
4
−7
3
13
70
81
5
−25
−1
14
63
55
8
−7
3
14
117
116
4
−5
−1
15
267
248
5


−13
−1
13
67
54
6
−5
3
13
47
43
7
−23
−1
14
96
88
6
−5
3
14
118
128
4
−3
−1
15
193
194
6


−11
−1
13
144
149
4
−3
3
13
157
158
3
−21
−1
14
77
111
10
−3
3
14
30
38
16
−1
−1
15
307
295
7


−9
−1
13
116
116
4
−1
3
13
108
110
9
−19
−1
14
91
98
6
−1
3
14
176
163
5
1
−1
15
69
60
9


−7
−1
13
66
63
6
1
3
13
41
32
16
−17
−1
14
107
99
5
1
3
14
211
205
6
3
−1
15
147
150
6


−5
−1
13
255
244
4
3
3
13
64
58
6
−15
−1
14
351
321
5
3
3
14
177
186
4
5
−1
15
74
84
9


−3
−1
13
185
186
4
5
3
13
125
134
12
−13
−1
14
311
294
6
5
3
14
68
81
6
7
−1
15
40
28
17


−1
−1
13
0
31
1
7
3
13
120
115
7
−11
−1
14
92
90
8
7
3
14
23
37
23
9
−1
15
25
54
25


1
−1
13
230
220
4
9
3
13
51
67
20
−9
−1
14
69
60
6
9
3
14
27
39
27
−28
0
15
0
3
1


3
−1
13
92
69
6
11
3
13
42
41
24
−7
−1
14
84
92
5
−22
4
14
34
11
34
−26
0
15
82
64
7


5
−1
13
216
211
7
−22
4
13
38
21
25
−5
−1
14
152
142
7
−20
4
14
37
56
28
−24
0
15
52
41
13


7
−1
13
148
152
6
−20
4
13
18
46
17
−3
−1
14
155
165
9
−18
4
14
69
68
12
−22
0
15
34
1
33


9
−1
13
36
24
21
−18
4
13
0
33
1
−1
−1
14
311
302
6
−16
4
14
83
90
12
−20
0
15
38
25
14


11
−1
13
65
64
9
−16
4
13
67
61
18
1
−1
14
358
351
6
−14
4
14
62
53
9
−18
0
15
93
72
5


13
−1
13
56
55
9
−14
4
13
86
79
7
3
−1
14
128
130
11
−12
4
14
132
119
8
−16
0
15
35
3
13


−28
0
13
25
12
24
−12
4
13
39
66
35
5
−1
14
61
77
10
−10
4
14
47
37
6
−14
0
15
191
183
9


−26
0
13
0
0
1
−10
4
13
168
151
8
7
−1
14
146
124
7
−8
4
14
112
96
3
−12
0
15
0
7
1


−24
0
13
32
42
31
−8
4
13
36
34
14
9
−1
14
12
31
12
−6
4
14
38
48
12
−10
0
15
98
104
4


−22
0
13
53
42
16
−6
4
13
68
70
6
11
−1
14
106
94
11
−4
4
14
71
79
6
−8
0
15
86
89
6


−20
0
13
138
145
8
−4
4
13
30
43
21
−28
0
14
4
3
3
−2
4
14
210
217
6
−6
0
15
181
177
4


−18
0
13
184
169
3
−2
4
13
52
53
7
−26
0
14
65
42
9
0
4
14
37
38
10
−4
0
15
159
160
7


−16
0
13
301
255
4
0
4
13
69
67
9
−24
0
14
38
2
18
2
4
14
58
63
5
−2
0
15
105
110
8


−14
0
13
0
22
1
2
4
13
139
135
8
−22
0
14
42
43
23
4
4
14
33
31
27
2
0
15
76
73
9


−12
0
13
94
85
4
4
4
13
59
61
10
−20
0
14
198
198
4
6
4
14
23
24
23
4
0
15
108
96
6


−10
0
13
53
37
6
6
4
13
20
9
19
−18
0
14
22
2
22
−17
5
14
43
69
10
6
0
15
10
13
9


−8
0
13
231
213
4
8
4
13
0
17
1
−16
0
14
86
79
4
−15
5
14
28
54
28
8
0
15
45
29
10


−6
0
13
97
98
4
−17
5
13
28
26
27
−14
0
14
190
166
3
−13
5
14
74
62
5
10
0
15
36
11
13


−4
0
13
38
38
10
−15
5
13
88
114
6
−12
0
14
72
75
5
−11
5
14
25
16
24
−25
1
15
25
40
25


−2
0
13
221
221
4
−13
5
13
41
50
13
−10
0
14
0
18
1
−9
5
14
70
66
6
−23
1
15
23
27
23


0
0
13
407
423
7
−11
5
13
72
71
9
−8
0
14
469
448
10
−7
5
14
77
71
5
−21
1
15
36
40
16


2
0
13
46
55
11
−9
5
13
76
71
6
−6
0
14
45
36
9
−5
5
14
16
23
15
−19
1
15
97
95
9


4
0
13
248
258
4
−7
5
13
26
27
26
−4
0
14
292
275
5
−1
5
14
52
35
13
−17
1
15
275
248
6


6
0
13
337
340
6
−5
5
13
79
78
5
−2
0
14
191
196
4
1
5
14
50
46
16
−15
1
15
40
47
12


8
0
13
114
109
8
−3
5
13
53
50
6
0
0
14
248
239
4
−20
−4
15
30
16
30
−13
1
15
155
152
4


10
0
13
37
59
14
−1
5
13
30
48
30
2
0
14
98
106
5
−18
−4
15
77
74
9
−11
1
15
41
39
12


12
0
13
21
12
21
−17
−5
14
54
69
11
4
0
14
420
408
7
−16
−4
15
73
66
10
−9
1
15
0
21
1


14
0
13
73
60
11
−15
−5
14
43
54
16
6
0
14
99
75
6
−14
−4
15
0
34
1
−7
1
15
106
104
7


−25
1
13
23
35
22
−13
−5
14
75
63
9
8
0
14
0
12
1
−12
−4
15
60
49
14
−5
1
15
269
247
4


−23
1
13
63
65
9
−22
−4
14
0
11
1
10
0
14
95
96
11
−10
−4
15
59
51
14
−3
1
15
193
194
4


−21
1
13
89
70
10
−20
−4
14
35
57
28
12
0
14
16
13
15
−8
−4
15
27
65
26
−1
1
15
296
295
7


1
1
15
54
60
9
−6
−2
16
165
158
6
−1
3
16
84
67
16
−7
1
17
0
17
1
−6
0
18
61
44
9


3
1
15
150
150
29
−4
−2
16
107
104
6
1
3
16
28
15
19
−5
1
17
121
105
10
−4
0
18
47
64
13


5
1
15
90
84
7
−2
−2
16
37
43
21
3
3
16
38
52
10
−3
1
17
126
111
12
−2
0
18
118
107
6


7
1
15
16
29
15
0
−2
16
73
78
10
5
3
16
24
16
13
−1
1
17
15
23
14
0
0
18
41
30
17


9
1
15
50
54
12
2
−2
16
49
40
12
−18
4
16
28
53
27
1
1
17
56
64
8
2
0
18
0
5
1


−26
2
15
49
55
19
4
−2
16
0
22
1
−16
4
16
30
29
25
3
1
17
20
12
20
4
0
18
84
79
8


−24
2
15
78
82
11
6
−2
16
35
22
34
−14
4
16
18
31
18
5
1
17
8
15
8
−23
1
18
79
67
11


−22
2
15
85
84
11
−27
−1
16
39
14
27
−12
4
16
50
42
10
−24
2
17
46
47
19
−21
1
18
43
40
12


−20
2
15
188
185
5
−25
−1
16
38
31
38
−10
4
16
73
94
7
−22
2
17
54
65
15
−19
1
18
52
37
10


−18
2
15
119
134
5
−23
−1
16
26
27
26
−8
4
16
131
121
7
−20
2
17
0
4
1
−17
1
18
0
14
1


−16
2
15
77
87
7
−21
−1
16
190
161
5
−6
4
16
61
62
6
−18
2
17
74
81
7
−15
1
18
34
35
34


−14
2
15
70
60
7
−19
−1
16
70
95
8
−4
4
16
34
38
13
−16
2
17
38
39
13
−13
1
18
144
153
6


−12
2
15
49
51
13
−17
−1
16
90
84
17
−2
4
16
56
57
6
−14
2
17
40
39
13
−11
1
18
101
93
7


−10
2
15
277
245
5
−15
−1
16
59
48
10
0
4
16
24
40
14
−12
2
17
122
145
6
−9
1
18
33
28
17


−8
2
15
132
121
8
−13
−1
16
69
86
9
−16
−4
17
26
49
25
−10
2
17
30
30
30
−7
1
18
68
60
7


−6
2
15
162
154
4
−11
−1
16
60
52
10
−14
−4
17
5
33
4
−8
2
17
121
113
6
−5
1
18
108
94
11


−4
2
15
101
98
5
−9
−1
16
175
177
6
−12
−4
17
75
67
10
−6
2
17
51
58
8
−3
1
18
28
9
27


−2
2
15
70
75
6
−7
−1
16
207
207
8
−10
−4
17
40
17
22
−4
2
17
61
67
7
−1
1
18
43
36
11


0
2
15
240
237
9
−5
−1
16
167
168
6
−21
−3
17
0
7
1
−2
2
17
0
7
1
1
1
18
66
71
7


2
2
15
33
33
17
−3
−1
16
25
47
25
−19
−3
17
21
29
20
0
2
17
14
29
13
3
1
18
32
38
15


4
2
15
30
43
29
−1
−1
16
127
123
16
−17
−3
17
19
34
19
2
2
17
31
28
19
−22
2
18
25
17
24


6
2
15
47
35
11
1
−1
16
25
31
25
−15
−3
17
13
36
13
4
2
17
28
39
28
−20
2
18
0
25
1


8
2
15
17
30
17
3
−1
16
0
38
1
−13
−3
17
51
49
18
−21
3
17
0
7
1
−18
2
18
0
14
1


−23
3
15
66
77
12
5
−1
16
72
65
9
−11
−3
17
47
31
22
−19
3
17
0
30
1
−16
2
18
89
97
6


−21
3
15
43
24
20
7
−1
16
31
18
31
−9
−3
17
0
28
1
−17
3
17
44
34
18
−14
2
18
32
48
26


−19
3
15
89
81
10
−26
0
16
25
20
25
−7
−3
17
65
82
13
−15
3
17
48
36
9
−12
2
18
61
45
15


−17
3
15
39
57
24
−24
0
16
17
5
17
−5
−3
17
37
47
36
−13
3
17
47
49
10
−10
2
18
115
108
5


−15
3
15
38
33
10
−22
0
16
52
14
18
−3
−3
17
0
43
1
−11
3
17
39
31
11
−8
2
18
59
77
8


−13
3
15
142
137
10
−20
0
16
80
75
6
−1
−3
17
0
17
1
−9
3
17
0
28
1
−6
2
18
37
38
12


−11
3
15
61
69
10
−18
0
16
23
3
22
1
−3
17
39
27
34
−7
3
17
69
82
8
−4
2
18
45
51
9


−9
3
15
64
54
7
−16
0
16
52
62
19
−24
−2
17
30
47
30
−5
3
17
48
48
8
−2
2
18
48
64
8


−7
3
15
73
83
8
−14
0
16
70
90
7
−22
−2
17
40
64
13
−3
3
17
34
43
12
0
2
18
36
28
13


−5
3
15
93
101
4
−12
0
16
0
8
1
−20
−2
17
26
4
25
−1
3
17
31
17
18
2
2
18
26
10
25


−3
3
15
147
155
8
−10
0
16
25
22
25
−18
−2
17
60
81
13
1
3
17
25
27
24
−19
3
18
39
35
20


−1
3
15
75
65
6
−8
0
16
151
137
6
−16
−2
17
18
39
18
−16
4
17
42
49
11
−17
3
18
0
1
1


1
3
15
144
141
4
−6
0
16
234
249
6
−14
−2
17
43
39
20
−14
4
17
49
33
13
−15
3
18
23
6
22


3
3
15
64
60
6
−4
0
16
77
81
8
−12
−2
17
151
145
8
−12
4
17
76
66
20
−13
3
18
19
26
19


5
3
15
12
15
12
−2
0
16
328
334
7
−10
−2
17
31
30
31
−10
4
17
28
17
27
−11
3
18
93
99
4


7
3
15
28
34
28
0
0
16
174
168
6
−8
−2
17
132
113
8
−8
4
17
28
29
15
−9
3
18
0
16
1


−20
4
15
17
16
16
2
0
16
87
87
10
−6
−2
17
62
58
10
−6
4
17
0
11
1
−7
3
18
55
54
7


−18
4
15
85
74
10
4
0
16
54
66
9
−4
−2
17
59
67
36
−4
4
17
79
78
4
−5
3
18
16
30
16


−16
4
15
65
65
13
6
0
16
15
8
15
−2
−2
17
0
7
1
−19
−3
18
56
35
13
−3
3
18
63
49
6


−14
4
15
31
34
28
8
0
16
162
143
9
0
−2
17
19
29
19
−17
−3
18
23
1
23
−1
3
18
22
27
22


−12
4
15
51
49
28
−25
1
16
34
31
33
2
−2
17
24
29
24
−15
−3
18
32
7
32
−15
−3
19
30
25
30


−10
4
15
62
51
9
−23
1
16
34
27
17
4
−2
17
43
39
23
−13
−3
18
38
27
38
−13
−3
19
53
42
16


−8
4
15
65
65
5
−21
1
16
170
162
12
−25
−1
17
0
17
1
−11
−3
18
70
99
12
−11
−3
19
0
17
1


−6
4
15
85
89
5
−19
1
16
96
95
11
−23
−1
17
124
129
8
−9
−3
18
20
16
20
−9
−3
19
32
48
32


−4
4
15
120
146
5
−17
1
16
89
83
7
−21
−1
17
21
3
21
−7
−3
18
65
54
13
−7
−3
19
12
40
12


−2
4
15
37
35
12
−15
1
16
46
49
12
−19
−1
17
49
67
26
−5
−3
18
26
30
25
−20
−2
19
32
14
32


0
4
15
20
20
20
−13
1
16
83
85
6
−17
−1
17
25
20
25
−3
−3
18
59
48
13
−18
−2
19
35
47
35


2
4
15
72
77
7
−11
1
16
39
52
16
−15
−1
17
27
55
27
−1
−3
18
23
26
22
−16
−2
19
38
21
34


4
4
15
29
22
29
−9
1
16
165
178
7
−13
−1
17
102
114
7
−22
−2
18
0
17
1
−14
−2
19
86
64
11


−13
5
15
55
60
10
−7
1
16
200
207
6
−11
−1
17
189
173
8
−20
−2
18
17
25
17
−12
−2
19
97
93
10


−11
5
15
52
46
11
−5
1
16
157
167
8
−9
−1
17
105
114
6
−18
−2
18
0
13
1
−10
−2
19
0
16
1


−9
5
15
68
68
6
−3
1
16
46
47
16
−7
−1
17
47
17
13
−16
−2
18
67
97
13
−8
−2
19
41
33
17


−7
5
15
58
53
9
−1
1
16
106
123
17
−5
−1
17
128
105
9
−14
−2
18
31
48
30
−6
−2
19
33
34
25


−5
5
15
28
35
11
1
1
16
18
31
17
−3
−1
17
126
111
18
−12
−2
18
61
45
15
−4
−2
19
32
27
31


−18
−4
16
59
53
12
3
1
16
20
38
19
−1
−1
17
0
23
1
−10
−2
18
110
108
6
−2
−2
19
59
57
14


−16
−4
16
17
29
17
5
1
16
83
65
9
1
−1
17
54
64
12
−8
−2
18
41
77
30
−21
−1
19
75
73
8


−14
−4
16
2
31
2
7
1
16
0
18
1
3
−1
17
0
12
1
−6
−2
18
39
38
21
−19
−1
19
0
26
1


−12
−4
16
50
41
16
−24
2
16
67
70
12
5
−1
17
22
15
22
−4
−2
18
45
51
14
−17
−1
19
0
28
1


−10
−4
16
72
94
10
−22
2
16
54
65
15
−26
0
17
71
56
7
−2
−2
18
57
64
17
−15
−1
19
60
40
10


−8
−4
16
126
121
8
−20
2
16
86
114
10
−24
0
17
17
15
17
0
−2
18
14
27
14
−13
−1
19
69
55
9


−23
−3
16
40
34
17
−18
2
16
108
122
8
−22
0
17
38
25
37
2
−2
18
0
10
1
−11
−1
19
73
74
9


−21
−3
16
29
41
29
−16
2
16
20
28
19
−20
0
17
42
28
13
−23
−1
18
68
67
8
−9
−1
19
66
70
10


−19
−3
16
0
11
1
−14
2
16
43
61
12
−18
0
17
14
35
13
−21
−1
18
30
40
30
−7
−1
19
22
34
21


−17
−3
16
58
48
13
−12
2
16
21
29
20
−16
0
17
127
120
5
−19
−1
18
35
37
35
−5
−1
19
0
6
1


−15
−3
16
47
71
18
−10
2
16
136
129
5
−14
0
17
179
158
5
−17
−1
18
7
14
6
−3
−1
19
0
10
1


−13
−3
16
59
52
14
−8
2
16
50
48
11
−12
0
17
202
206
8
−15
−1
18
24
35
23
−1
−1
19
56
49
11


−11
−3
16
59
48
15
−6
2
16
156
159
5
−10
0
17
110
89
13
−13
−1
18
153
153
18
1
−1
19
19
27
19


−9
−3
16
63
74
14
−4
2
16
102
104
8
−8
0
17
0
21
1
−11
−1
18
99
93
10
−22
0
19
0
46
1


−7
−3
16
34
21
34
−2
2
16
28
44
23
−6
0
17
80
85
7
−9
−1
18
0
27
1
−20
0
19
34
47
17


−5
−3
16
43
52
14
0
2
16
89
78
5
−4
0
17
113
161
6
−7
−1
18
66
59
10
−18
0
19
28
22
28


−3
−3
16
110
106
9
2
2
16
46
40
10
−2
0
17
64
62
9
−5
−1
18
106
94
7
−16
0
19
45
40
12


−1
−3
16
49
66
19
4
2
16
12
21
12
0
0
17
91
104
7
−3
−1
18
0
9
1
−14
0
19
36
33
17


1
−3
16
30
14
29
6
2
16
21
22
21
2
0
17
25
43
24
−1
−1
18
32
36
31
−12
0
19
41
33
14


3
−3
16
42
52
30
−23
3
16
30
34
30
4
0
17
53
51
9
1
−1
18
81
71
11
−10
0
19
125
108
6


5
−3
16
14
15
13
−21
3
16
43
41
19
6
0
17
73
70
6
3
−1
18
46
38
19
−8
0
19
0
8
1


−24
−2
16
52
70
9
−19
3
16
22
11
22
−25
1
17
37
17
37
−24
0
18
0
23
1
−6
0
19
45
28
15


−22
−2
16
47
64
11
−17
3
16
68
47
12
−23
1
17
132
129
9
−22
0
18
28
38
28
−4
0
19
36
23
22


−20
−2
16
88
114
9
−15
3
16
70
71
10
−21
1
17
0
3
1
−20
0
18
28
6
27
−2
0
19
33
44
32


−18
−2
16
92
122
9
−13
3
16
46
52
10
−19
1
17
65
67
9
−18
0
18
0
3
1
0
0
19
81
64
15


−16
−2
16
22
28
22
−11
3
16
54
48
9
−17
1
17
42
20
17
−16
0
18
45
71
12
−21
1
19
67
73
6


−14
−2
16
66
62
12
−9
3
16
62
73
8
−15
1
17
40
55
14
−14
0
18
0
48
1
−19
1
19
0
26
1


−12
−2
16
51
29
16
−7
3
16
27
21
27
−13
1
17
91
114
10
−12
0
18
17
24
16
−17
1
19
28
28
27


−10
−2
16
131
129
6
−5
3
16
56
51
8
−11
1
17
176
173
11
−10
0
18
42
56
17
−15
1
19
55
40
12


−8
−2
16
41
48
16
−3
3
16
110
106
4
−9
1
17
107
113
5
−8
0
18
74
95
8
−13
1
19
61
55
8


−11
1
19
69
74
7
−6
2
19
24
34
24
−19
−1
20
40
58
16
−10
0
20
0
0
1
−14
2
20
40
47
39


−9
1
19
64
71
8
−4
2
19
38
27
10
−17
−1
20
0
39
1
−8
0
20
0
23
1
−12
2
20
23
14
22


−7
1
19
27
34
27
−2
2
19
60
57
6
−15
−1
20
0
34
1
−6
0
20
13
32
12
−10
2
20
33
48
16


−5
1
19
4
6
3
−15
3
19
47
25
15
−13
−1
20
69
62
21
−4
0
20
19
12
19
−8
2
20
63
66
10


−3
1
19
0
10
1
−13
3
19
48
42
6
−11
−1
20
0
15
1
−19
1
20
47
58
9
−6
2
20
29
23
15


−1
1
19
55
49
8
−11
3
19
0
17
1
−9
−1
20
33
21
32
−17
1
20
31
39
30
−13
−1
21
26
20
25


1
1
19
36
27
12
−9
3
19
46
48
8
−7
−1
20
49
13
13
−15
1
20
45
34
10
−11
−1
21
29
22
29


−20
2
19
27
14
26
−7
3
19
34
40
12
−5
−1
20
41
29
17
−13
1
20
53
62
9
−16
0
21
0
27
1


−18
2
19
56
47
15
−16
−2
20
25
14
25
−3
−1
20
27
24
26
−11
1
20
19
15
18
−14
0
21
24
5
24


−16
2
19
29
21
28
−14
−2
20
42
47
25
−20
0
20
59
58
8
−9
1
20
18
21
17
−12
0
21
11
6
11


−14
2
19
81
63
14
−12
−2
20
0
14
1
−18
0
20
51
20
9
−7
1
20
0
13
1
−10
0
21
25
36
25


−12
2
19
101
93
11
−10
−2
20
52
48
11
−16
0
20
58
54
8
−5
1
20
21
29
21
−8
0
21
0
10
1


−10
2
19
20
16
20
−8
−2
20
76
66
7
−14
0
20
14
21
14
−3
1
20
31
24
16
−13
1
21
0
20
1


−8
2
19
28
34
28
−6
−2
20
30
23
29
−12
0
20
29
37
29
−16
2
20
0
14
1
−11
1
21
41
21
15









REFERENCES


    1. CrysAlis RED, Oxford Diffraction Ltd., Version 1.171.28 cycle2 beta (release Oct. 25, 2005 CrysAlis171.NET) (compiled Oct. 25, 2005, 08:50:05). Empirical absorption correction using spherical harmonics, implemented in SCALE3 ABSPACK scaling algorithm.
    2. CrysAlis CCD, Oxford Diffraction Ltd., Version 1.171.28 cycle2 beta; CrysAlis RED, Oxford Diffraction Ltd., Version 1.171.28 cycle2 beta.
    3. G. M. Sheldrick, Acta Crystallogr. 1990, A46, 467-473.
    4. G. M. Sheldrick, SHELXL93. Program for the Reminement of Crystal Structures, Univ. of Göttingen, Germany.
    5. International Tables for Crystallography, Ed. A. J. C. Wilson, Kluwer:Dordrecth, 1992, Vol. C.


Example 3
Synthesis of MET-1 and MET-2
The preparation of MET-1 and MET-2 having the basic structures I and II can be accomplished by a common general method otherwise referred to as the condensation of a bicyclic Windaus-Grundmann type ketone IIIa or IIIb with the allylic phosphine oxide IV to the corresponding 2-methylene-19-nor-vitamin D analog Va or Vb followed by deprotection at C-1 and C-3 in the latter compound Va or Vb to obtain compound I (MET-1) or compound II (MET-2).




In phosphine oxide IV, Y1 and Y2 are preferably hydroxy-protecting groups such as silyl protecting groups. The t-butyldimethylsilyl (TMDMS) group is an example of a particularly useful hydroxy-protecting group. The process described above represents an application of the convergent synthesis concept, which has been applied effectively to the preparation of numerous vitamin D compounds. (See Lythgoe et al., J. Chem. Soc. Perkin Trans. I, 590 (1978); Lythgoe, Chem. Soc. Rev. 9, 449 (1983); Toh et al., J. Org. Chem. 48, 1414 (1983); Baggiolini et al., J. Org. Chem. 51, 3098 (1986); Sardina et al., J. Org. Chem. 51, 1264 (1986); J. Org. Chem. 51, 1269 (1986); DeLuca et al., U.S. Pat. No. 5,086,191; DeLuca et al., U.S. Pat. No. 5,536,713; and DeLuca et al., U.S. Pat. No. 5,843,928 all of which are hereby incorporated by reference in their entirety and for all purposes as if fully set forth herein).
Phosphine oxide IV is a convenient reagent that can be used to prepare a large number of 19-nor-vitamin D compounds and is prepared according to the procedures described by Sicinski et al., J. Med. Chem., 41, 4662 (1998); DeLuca et al., U.S. Pat. No. 5,843,928; Perlman et al., Tetrahedron Lett. 32, 7663 (1991); and DeLuca et al., U.S. Pat. No. 5,086,191; which are hereby incorporated by reference in their entirety as if fully set forth herein.
An overall process for the synthesis of compounds I and II is illustrated and described more completely in U.S. Pat. No. 5,843,928 entitled “2-Alkylidene-19-Nor-Vitamin D Compounds” and in U.S. patent application Ser. No. 13/053,844 filed Mar. 22, 2011, entitled “(20S)-2-Methylene-19-Nor-22-Dimethyl-1α,25-Dihydroxyvitamin D3 and (20R)-2-Methylene-19-Nor-22-Dimethyl-1α,25-Hydroxyvitamin D3” published as U.S. Publication No. US 2011/0237556A1 the specification of which is specifically incorporated herein by reference.

## Claims

1. A compound having the formula




in crystalline form, wherein the methyl group attached to carbon 20 may be in its R or S orientation.

2. (20S)-2-methylene-19-nor-22-dimethyl-1α,25-dihydroxyvitamin D3 in crystalline form.

3. A crystalline form of (20S)-2-methylene-19-nor-22-dimethyl-1α,25-dihydroxyvitamin D3 having molecular packing arrangement defined by space group P2(1) and unit cell dimensions a=7.57 Å b=14.79 Å c=14.48 Å α=90°, β=102.2° and γ=90°.

4. A three dimensional structure for (20S)-2-methylene-19-nor-22-dimethyl-1α,25-dihydroxyvitamin D3 as defined by the molecular packing arrangement set forth in claim 3.

5. A method of purifying (20S)-2-methylene-19-nor-22-dimethyl-1α,25-dihydroxyvitamin D3, comprising the steps of:
(a) preparing a solvent comprising diethyl ether;
(b) dissolving a product containing (20S)-2-methylene-19-nor-22-dimethyl-1α,25-dihydroxyvitamin D3 to be purified in said solvent;
(c) cooling said solvent and dissolved product below ambient temperature for a sufficient amount of time to form a precipitate of (20S)-2-methylene-19-nor-22-dimethyl-1α,25-dihydroxyvitamin D3 crystals; and
(d) separating the (20S)-2-methylene-19-nor-22-dimethyl-1α,25-dihydroxyvitamin D3 crystals from the solvent.

6. The method of claim 5 including the further step of allowing said solvent and dissolved product to cool to ambient temperature prior to cooling below ambient temperature.

7. The method of claim 5 wherein said solvent comprises 100% diethyl ether, by volume.

8. The method of claim 5 wherein the step of separating comprises filtering the solvent and precipitate to obtain the crystals.

9. The method of claim 5 including a further step (e) comprising repeating steps (a) through (d) using the recovered crystals from step (d) as the product of step (b).

10. (20R)-2-methylene-19-nor-22-dimethyl-1α,25-dihydroxyvitamin D3 in crystalline form.

11. A crystalline form of (20R)-2-methylene-19-nor-22-dimethyl-1α,25-dihydroxyvitamin D3 having molecular packing arrangement defined by space group C2 and unit cell dimensions a=27.33 Å b=6.68 Å c=19.22 Å α=90°, β=113.57° and γ=90°.

12. A three dimensional structure for (20R)-2-methylene-19-nor-22-dimethyl-1α,25-dihydroxyvitamin D3 as defined by the molecular packing arrangement set forth in claim 11.

13. A method of purifying (20R)-2-methylene-19-nor-22-dimethyl-1α,25-dihydroxyvitamin D3, comprising the steps of:
(a) preparing a solvent comprising hexane;
(b) adding a product containing (20R)-2-methylene-19-nor-22-dimethyl-1α,25-dihydroxyvitamin D3 to be purified to said hexane to form a suspension of the product in the hexane;
(c) adding 2-propanol dropwise to the suspension to form a mixture of the product in the hexane and 2-propanol;
(d) heating the mixture to dissolve the product containing (20R)-2-methylene-19-nor-22-dimethyl-1α,25-dihydroxyvitamin D3 to be purified in said mixture;
(e) cooling said mixture and dissolved product below ambient temperature for a sufficient amount of time to form a precipitate of (20R)-2-methylene-19-nor-22-dimethyl-1α,25-dihydroxyvitamin D3 crystals; and
(f) separating the (20R)-2-methylene-19-nor-22-dimethyl-1α,25-dihydroxyvitamin D3 crystals from the mixture.

14. The method of claim 13 including the further step of allowing said mixture and dissolved product to cool to ambient temperature prior to cooling below ambient temperature.

15. The method of claim 13 wherein the step of separating comprises filtering the mixture and precipitate to obtain the crystals.

16. The method of claim 13 including a further step (g) comprising repeating steps (a) through (f) using the recovered crystals from step (f) as the product of step (b).

17. The method of claim 13 wherein said mixture comprises about 15% 2-propanol and about 85% hexane, by volume.