Exhibit 21.1

PROSPERITY BANCSHARES, INC.

LIST OF SUBSIDIARIES



|                                              |  |                              |  |                                    
|--------------------------------------------- |  | ---------------------------- |  | -----------------------------------
|Direct Subsidiaries                           |  | Jurisdiction of Organization |  | Parent Entity                      
|                                              |  |                             
|Prosperity Holdings of Delaware, LLC          |  | Delaware                     |  | Prosperity Bancshares, Inc.        
|                                              |  |                             
|Prosperity Interim Corporation                |  | Texas                        |  | Prosperity Bancshares, Inc.        
|                                              |  |                             
|Prosperity Statutory Trust II                 |  | Connecticut                  |  | Prosperity Bancshares, Inc.        
|                                              |  |                             
|Prosperity Statutory Trust III                |  | Connecticut                  |  | Prosperity Bancshares, Inc.        
|                                              |  |                             
|Prosperity Statutory Trust IV                 |  | Connecticut                  |  | Prosperity Bancshares, Inc.        
|                                              |  |                             
|SNB Capital Trust IV                          |  | Connecticut                  |  | Prosperity Bancshares, Inc.        
|                                              |  |                             
|TXUI Statutory Trust I                        |  | Connecticut                  |  | Prosperity Bancshares, Inc.        
|                                              |  |                             
|TXUI Statutory Trust II                       |  | Delaware                     |  | Prosperity Bancshares, Inc.        
|                                              |  |                             
|TXUI Statutory Trust III                      |  | Connecticut                  |  | Prosperity Bancshares, Inc.        
|                                              |  |                             
|TXUI Statutory Trust IV                       |  | Delaware                     |  | Prosperity Bancshares, Inc.        
|                                              |  |                             
|Indirect Subsidiaries                         |  | Jurisdiction of Organization |  | Parent Entity                      
|                                              |  |                             
|First National Bryan Security Company, L.L.C. |  | Texas                        |  | Prosperity Bank                    
|                                              |  |                             
|GNB Leasing Co.                               |  | Texas                        |  | Prosperity Bank                    
|                                              |  |                             
|MainCorp Leasing Co.                          |  | Texas                        |  | Prosperity Bank                    
|                                              |  |                             
|LB Holdings, Inc.                             |  | Texas                        |  | Prosperity Bank                    
|                                              |  |                             
|Prosperity Bank                               |  | Texas                        |  | Prosperity Holdings of Delaware,LLC