Federal Register / Vol. 70, No. 23 / Friday, February 4, 2005 / Notices 6023

5600 Fishers Lane, Rockville, Maryland 

20857.

FOR FURTHER INFORMATION CONTACT: Ms. 

Lynn Spector, Division of Health Center 

Development, Bureau of Primary Health 

Care, HRSA. Ms. Spector may be 

contacted by e-mail at lspector@hrsa.gov

or via telephone at (301) 594–4300.

Dated: February 1, 2005. 

Elizabeth M. Duke, 

Administrator.

[FR Doc. 05–2215 Filed 2–1–05; 4:24 pm] 

BILLING CODE 4165–15–C

DEPARTMENT OF HEALTH AND 

HUMAN SERVICES 

National Institutes of Health 

Proposed Collection; Comment 

Request; Physical Activity and Its 

Components In Relation To Plasma 

Inflammatory Markers of Cancer Risks 

Among Chinese Adults

SUMMARY: In compliance with the 

requirement of Section 3506(c)(2)(A) of 

the Paperwork Reduction Act of 1995, 

for opportunity for public comment on 

proposed data collection projects, the 

National Cancer Institute (NCI), the 

National Institutes of Health (NIH) will 

publish periodic summaries of proposed 

projects to be submitted to the Office of 

Management and Budget (OMB) for 

review and approval. 

Proposed Collection 

Title: Physical Activity And Its 

Components In Relation To Plasma 

Inflammatory Markers Of Cancer Risks 

Among Chinese Adults. 

Type of Information Collection 

Request: NEW. 

Need and Use of Information 

Collection: The specific objectives of the 

current study are to: (1) Develop a 

comprehensive physical activity 

questionnaire that includes 

standardized questions about all types 

of physical activity (e.g., recreational, 

household, occupational, and 

transportation), and all parameters of 

physical activity (e.g., frequency, 

intensity; and duration in hours per 

week; (2) to assess the validity and 

reliability of this comprehensive 

physical activity questionnaire and the 

currently used baseline physical activity 

questionnaire in two existing study 

cohorts using objective measures of 

physical activity/physical fitness 

(activity monitors and step test), and; (3) 

to evaluate whether types and 

parameters of physical activity are 

associated with circulating levels of 

specific inflammatory markers that have 

been linked to cancer risk, independent 

of body mass and other potentially 

confounding variables. The specific 

markers are C-reactive protein (CRP), 

interleukin 6 (IL–6), and soluble tumor 

necrosis factor alpha (TNF-’’). 

The findings of this study will 

contribute to research in several 

important ways. They will allow the 

collection of objective physical activity 

measurements using activity monitors 

within a population with a wide range 

of between-person variation in physical 

activity; add to our understanding of the 

relationship of individual types of 

physical activity (e.g., recreational, 

household, occupational, and 

transportation), and parameters of 

physical activity (e.g., frequency, 

intensity, and duration in hours per 

week) to cancer outcomes; allow the use 

of physical activity information together 

with detailed, prospectively collected 

information regarding other lifestyle 

factors, such as diet and body mass, 

factors that are highly correlated with 

physical activity and also represent 

strong independent determinants of 

inflammatory mediator production, and; 

should the anticipated associations be 

found, the current study will likely 

stimulate future studies aimed at 

independently and jointly evaluating 

physical activity and chronic low-grade 

systemic inflammation in relation to 

cancer of several sites. 

Frequency of Response: Once a month 

during a twelve-month period. 

Affected Public: Approximately 600 

men and women from a current cohort 

study among 75,000 women and 73,000 

men and residing in Shanghai, China 

who agree to participate in this study. 

Type of Respondents: Adult men and 

women aged 40 to 70 years old who are 

residents of Shanghai, China and 

current participants in another ongoing 

study. The annual reporting burden is as 

follows: 

Estimated Number of Respondents:

600. 

Estimates of Respondent Hour Burden 

and Annualized Cost to Respondents:

Type of respondents Survey instruments per respondents Number of 

participants 

Frequency of 

response 

Average burden hours per 

response 

Total annual 

hour burden 

Adults (40–70 yrs old) ....................... Physical Activity Questionnaire ........ 600 2 0.5 600 

7-Day Physical Activity Record ........ 600 4 1.4 3360 

1-Week Physical Activity Recall ....... 600 12 0.25 1800 

TOTAL ....................................... ........................................................... 600 ........................ ........................ 5,760 

There are no Capital Costs to report. 

There are no Operating or Maintenance 

Costs to report. 

Request for Comments: Written 

comments and/or suggestions from the 

public and affected agencies are invited 

on one or more of the following points: 

(1) Whether the proposed collection of 

information is necessary for the proper 

performance of the function of the 

agency, including whether the 

information will have practical utility; 

(2) The accuracy of the agency’s 

estimate of the burden of the proposed 

collection of information, including the 

validity of the methodology and 

assumptions used; (3) Ways to enhance 

the quality, utility, and clarity of the 

information to be collected; and (4) 

Ways to minimize the burden of the 

collection of information on those who 

are to respond, including the use of 

appropriate automated, electronic, 

mechanical, or other technological 

collection techniques or other forms of 

information technology.

FOR FURTHER INFORMATION CONTACT: To 

request more information on the 

proposed project or to obtain a copy of 

the data collection plans and 

instruments, contact Michael F. 

Leitzmann, M.D., Dr. P.H., Nutritional 

Epidemiology Branch, Division of 

Cancer Epidemiology and Genetics, 

National Cancer Institute, NIH, DHHS, 

6120 Executive Blvd., EPS–MSC 7232, 

Bethesda, MD, 20892, U.S.A. or call 

non-toll-free number 301–402–3491 or 

E-mail your request, including your 

address to: leitzmann@mail.nih.gov. 

Comments Due Date: Comments 

regarding this information collection are 

best assured of having their full effect if 

received within 60 days of the date of 

this publication.

6024 Federal Register / Vol. 70, No. 23 / Friday, February 4, 2005 / Notices 

Dated: January 25, 2005. 

Rachelle Ragland-Greene, 

NCI Project Clearance Liaison, National 

Institutes of Health.

[FR Doc. 05–2127 Filed 2–3–05; 8:45 am] 

BILLING CODE 4140–01–P

DEPARTMENT OF HEALTH AND 

HUMAN SERVICES 

National Institutes of Health 

National Toxicology Program (NTP); 

Center for the Evaluation of Risks to 

Human Reproduction (CERHR); 

Announcement of Plans for Future 

Evaluation of Di(2-

ethylhexyl)phthalate; Request for 

Public Comments on this Chemical; 

and Solicitation for the Nomination of 

Scientists Qualified to Serve on an 

Expert Panel

AGENCY: National Institute for 

Environmental Health Sciences 

(NIEHS); National Institutes of Health 

(NIH), Department of Health and Human 

Services (HHS).

ACTION: Notice of expert panel 

evaluation of the reproductive and 

developmental toxicities of di(2-

ethylhexyl)phthalate. 

SUMMARY: The CERHR plans to convene 

an expert panel to evaluate the scientific 

evidence regarding the potential 

reproductive and/or developmental 

toxicity associated with exposure to 

di(2-ethylhexyl)phthalate (DEHP). The 

expert panel will consist of 

approximately 8–12 scientists selected 

for their scientific expertise in various 

aspects of reproductive and 

developmental toxicology and other 

relevant areas of science. The CERHR 

invites the submission of public 

comments on DEHP and the nomination 

of scientists to serve on the expert panel 

for its evaluation (see SUPPLEMENTARY

INFORMATION below). This meeting is 

tentatively scheduled for fall 2005, 

although the exact date and location are 

not yet established. As plans are 

finalized, they will be announced in the 

Federal Register and posted on the 

CERHR Web site (http://

cerhr.niehs.nih.gov). CERHR expert 

panel meetings are open to the public 

with time scheduled for oral public 

comment.

DATES: Information and comments 

received by March 21, 2005, will be 

made available to the CERHR staff and 

the expert panel for consideration in the 

evaluation and posted on the CERHR 

Web site. Nominations of scientists 

received by March 21, 2005, will be 

considered for this panel and for 

inclusion in the CERHR Expert Registry.

ADDRESSES: Information and comments 

should be sent to Dr. Michael D. Shelby, 

CERHR Director, NIEHS, P.O. Box 

12233, MD EC–32, Research Triangle 

Park, NC 27709 (mail), (919) 316–4511 

(fax), or shelby@niehs.nih.gov (e-mail). 

Courier address: CERHR, 79 T.W. 

Alexander Drive, Building 4401, Room 

103, Research Triangle Park, NC 27709.

FOR FURTHER INFORMATION CONTACT: Dr. 

Michael D. Shelby, CERHR Director, 

(919) 541–3455, shelby@niehs.nih.gov.

SUPPLEMENTARY INFORMATION: 

Background 

DEHP is a high production chemical 

used as a plasticizer of polyvinyl 

chloride in the manufacturer of a wide 

variety of consumer products, such as 

building products, car products, 

clothing, food packaging, children’s 

products (but not in toys intended for 

mouthing) and in polyvinyl chloride 

medical devices. In 1999–2000, a NTP–

CERHR expert panel evaluated DEHP 

and six other phthalates for 

reproductive and developmental 

toxicities. Since release of the NTPCERHR expert panel report on DEHP in 

2000, approximately 70 papers relevant 

to human exposure and reproductive 

and/or developmental toxicity of DEHP 

have been published. Because this is a 

chemical with wide human exposure 

and public and government interest, 

CERHR plans to convene an expert 

panel to conduct an updated evaluation 

of the potential reproductive and 

developmental toxicities of DEHP. 

Request for Comments 

The CERHR invites the public and 

other interested parties to submit 

information and comments on DEHP 

including toxicology information from 

completed and ongoing studies, 

information on planned studies, and 

information about current production 

levels, human exposure, use patterns, 

and environmental occurrence. 

Request for the Nomination of Scientist 

for the Expert Panel 

The CERHR invites nominations of 

qualified scientists to serve on the 

expert panel. Panelists are primarily 

drawn from the CERHR Expert Registry 

and/or the nomination of other 

scientists who meet the criteria for 

listing in that registry which include: 

formal academic training and 

experience in a relevant scientific field, 

publications in peer-reviewed journals, 

membership in relevant professional 

societies, and certification by an 

appropriate scientific board or other 

entities. Expert panel members are 

required to sign conflict of interest 

forms in accordance with Federal 

Advisory Committee Act Guidelines (5 

U.S.C. Appendix 2). 

All panel members serve as 

individual experts and not as 

representatives of their employers or 

other organizations. Scientists on the 

expert panel will be selected to 

represent a wide range of expertise 

including, but not limited to, 

developmental toxicology, reproductive 

toxicology, epidemiology, general 

toxicology, pharmacokinetics, exposure 

assessment, and biostatistics. 

Nominations should include contact 

information and a current curriculum 

vitae (if possible) and be forwarded to 

the CERHR at the address given above. 

Background Information on the CERHR 

The NTP established the CERHR in 

June 1998 (Federal Register, December 

14, 1998: Volume 63, Number 239, page 

68782). The CERHR is a publicly 

accessible resource for information 

about adverse reproductive and 

developmental health effects associated 

with environmental exposures. Expert 

panels conduct scientific evaluations of 

agents selected by the CERHR in public 

forums. 

Information about CERHR and its 

process for nominating agents for review 

or scientists for its expert registry can be 

obtained from its Web site (http://

cerhr.niehs.nih.gov) or by contacting Dr. 

Shelby (contact information provided 

above). The CERHR selects chemicals 

for evaluation based upon several 

factors, including production volume, 

extent of human exposure, public 

concern, and extent of the database on 

reproductive or developmental toxicity 

studies. 

CERHR follows a formal, multi-step 

process for review and evaluation of 

selected chemicals. The formal 

evaluation process was published in the 

Federal Register (July 16, 2001: Volume 

66, Number 136, pages 37047–37048) 

and is available on the CERHR Web site 

under ‘‘About CERHR’’ or in printed 

copy from the CERHR.

Dated: January 27, 2005. 

Samuel H. Wilson, 

Deputy Director, National Institute of 

Environmental Health Sciences.

[FR Doc. 05–2125 Filed 2–3–05; 8:45 am] 

BILLING CODE 4140–01–P