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                                                                   EXHIBIT 10.29

                              AMENDED AND RESTATED
                              --------------------

                              EMPLOYMENT AGREEMENT
                              --------------------

     THIS AMENDED AND RESTATED EMPLOYMENT AGREEMENT (the "Agreement") by and
between INCYTE GENOMICS, INC., a Delaware corporation (the "Company"), and John
M. Vuko (the "Executive"), effective as of the 26th day of November, 2001.

     The Board of Directors of the Company (the "Board"), has determined that it
is in the best interests of the Company and its stockholders to assure that the
Company will have the continued dedication of the Executive, notwithstanding the
possibility, threat or occurrence of a Change in Control (as defined below) of
the Company. The Board believes it is imperative to diminish the inevitable
distraction of the Executive by virtue of the personal uncertainties and risks
created by a pending or threatened Change in Control and to encourage the
Executive's full attention and dedication to the Company currently and in the
event of any threatened or pending Change in Control, and to provide the
Executive with compensation and benefits arrangements upon a Change in Control
and an event of Change in Control Good Reason which ensure that the compensation
and benefits expectations of the Executive will be satisfied and which are
competitive with those of other comparable corporations. In addition, as an
inducement to the agreement by Executive to continue to be employed by the
Company prior to a Change in Control on an "at will" basis, the Company desires
to provide Executive with certain benefits upon termination of Executive's
employment under certain circumstances as set forth herein. Therefore, in order
to accomplish these objectives, the Board has caused the Company to enter into
this Agreement.

     NOW, THEREFORE, IT IS HEREBY AGREED AS FOLLOWS:

     SECTION 1. DEFINITIONS.

     (a) "Annual Base Salary" shall mean the highest rate of annual base salary
paid or payable, including any base salary which has been earned but deferred,
to the Executive by the Company and its affiliated companies in respect of the
12-month period immediately preceding the month in which the Change in Control
or, in the case of termination other than on account of a Change in Control, the
Date of Termination occurs.

     (b) "Business Unit" shall mean a Subsidiary or a business division of the
Company or Subsidiary in which the Executive is primarily employed.

     (c) "Cause" shall mean:

          (i) The willful and continued failure of the Executive to perform
     substantially the Executive's duties with the Company or one of its
     affiliates (other than any such

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     failure resulting from incapacity due to physical or mental illness or
     impairment), after a written demand for substantial performance is
     delivered to the Executive by the Board or the Chief Executive Officer of
     the Company which specifically identifies the manner in which the Board or
     Chief Executive Officer believes that the Executive has not substantially
     performed the Executive's duties; or

          (ii)  The willful engaging by the Executive in illegal conduct, gross
     misconduct or dishonesty which is materially and demonstrably injurious to
     the Company; or

          (iii) Unauthorized and prejudicial disclosure or misuse of the
     Company's secret, confidential or proprietary information, knowledge or
     data relating to the Company or its affiliates.

          Notwithstanding the foregoing, "Cause" shall not include any act, or
     failure to act, based upon authority given pursuant to a resolution duly
     adopted by the Board or upon the instructions of the Chief Executive
     Officer or based upon the advice of counsel for the Company. The cessation
     of employment of the Executive shall not be deemed to be for Cause unless
     and until there shall have been delivered to the Executive a copy of a
     resolution duly adopted by the affirmative vote of not less than
     three-quarters of the entire membership of the Board at a meeting of the
     Board called and held for such purpose (after reasonable notice is provided
     to the Executive and the Executive is given an opportunity, together with
     counsel, to be heard before the Board), finding that, in the good faith
     opinion of the Board, the Executive is guilty of the conduct described in
     subparagraph (i), (ii) or (iii) above, and specifying the particulars
     thereof in detail.

     (d)  "Change in Control" shall mean the occurrence of any of the following
events:

          (i)   A change in the composition of the Board, as a result of which
     fewer than one-half of the incumbent directors are directors who either:

                (A) Had been directors of the Company 24 months prior to such
          change; or

                (B) Were elected, or nominated for election, to the Board with
          the affirmative votes of at least a majority of the directors who had
          been directors of the Company 24 months prior to such change and who
          were still in office at the time of the election or nomination;

          (ii)  Any "person" (as such term is used in Sections 13(d) and 14(d)
     of the Exchange Act) by the acquisition or aggregation of securities is or
     becomes the beneficial owner, directly or indirectly, of securities of the
     Company representing 50% or more of the combined voting power of the
     Company's then outstanding securities ordinarily (and apart from rights
     accruing under special circumstances) having the right to vote at elections
     of directors (the "Base Capital Stock"); except that any change in the
     relative beneficial ownership of the Company's securities by any person
     resulting solely from a reduction in the aggregate number of outstanding
     shares of Base Capital Stock, and any decrease thereafter in such person's
     ownership of securities, shall be disregarded until

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     such person increases in any manner, directly or indirectly, such person's
     beneficial ownership of any securities of the Company;

          (iii) The stockholders of the Company approve a plan of complete
     liquidation or dissolution of the Company;

          (iv)  There is consummated an agreement for the sale or disposition by
     the Company of all or substantially all of the Company's assets, other than
     a sale or disposition by the Company to a Subsidiary or to an entity, the
     voting securities of which are owned by stockholders of the Company in
     substantially the same proportions as their ownership of the Company
     immediately prior to such sale; or

          (v)   The sale, transfer or other disposition of a substantial portion
     of the stock or assets of the Company or a Business Unit or a similar
     transaction as the Board, in each case, in its sole discretion, may
     determine to be a Change in Control.

     The term "Change in Control" shall not include a transaction, the sole
purpose of which is to change the state of the Company's incorporation or the
initial public offering of the stock of a Business Unit.

     (e) "Change in Control Employment Period" shall mean the 24-month period
following the occurrence of a Change in Control.

     (f) "Change in Control Good Reason" shall mean:

          (i)   The assignment to Executive of any duties inconsistent with
     Executive's position (including status, offices, titles and reporting
     requirements), authority, duties or responsibilities as in effect
     immediately prior to a Change in Control or any other action by the Company
     that results in a diminishment in such position, authority, duties or
     responsibilities; or

          (ii)  (A) Except as required by law, the failure by the Company to
     continue to provide to Executive benefits substantially equivalent or more
     beneficial (including in terms of the amount of benefits provided and the
     level of participation of Executive relative to other participants), in the
     aggregate, to those enjoyed by Executive under the Company's employee
     benefit plans (including, without limitation, any pension, deferred
     compensation, split-dollar life insurance, supplemental retirement,
     retirement or savings plan(s) or program(s)) and Welfare Benefits in which
     Executive was eligible to participate immediately prior to the Change in
     Control; or (B) the taking of any action by the Company that would,
     directly or indirectly, materially reduce or deprive Executive of any other
     benefit, perquisite or privilege enjoyed by Executive immediately prior to
     the Change in Control, other than an isolated, insubstantial and
     inadvertent failure not occurring in bad faith and that is remedied by the
     Company promptly after receipt of notice thereof given by the Executive; or

          (iii) The Company's requiring the Executive to be based at any office
     or location more than 35 miles from the office or location where the
     Executive is based immediately prior to the Change in Control; or

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          (iv)  Any reduction in the Executive's Base Salary or Target Bonus
     opportunity; or

          (v)   A material breach by the Company of this Agreement.

     (g) "Disability" shall mean the absence of the Executive from the
Executive's duties with the Company on a full-time basis for 180 consecutive
business days as a result of incapacity due to mental or physical illness or
impairment which is determined to be total and permanent by a physician selected
by the Company or its insurers and acceptable to the Executive or the
Executive's legal representative.

     (h) "Employment Agreements" shall mean this Agreement and all other
employment agreements with executive officers of the Company similar to this
Agreement that are in effect as of the first Change in Control to occur after
April 1, 2001.

     (i) "Employment Period" means the period the Executive is employed by the
Company prior to the Change in Control Employment Period and the period the
Executive is employed by the Company after the end of a Change in Control
Employment Period.

     (j) "Good Reason" shall mean:

          (i)   The assignment to Executive of any duties substantially and
     materially inconsistent with Executive's position (including status,
     offices, titles and reporting requirements), authority, duties or
     responsibilities as in effect immediately prior to the Date of Termination
     or any other action by the Company that results in a substantial and
     material diminishment in such position, authority, duties or
     responsibilities; or

          (ii)  The Company's requiring the Executive to be based at any office
     or location more than 35 miles from Palo Alto, California; or

          (iii) Any substantial and material reduction in the Executive's Base
     Salary, Target Bonus opportunity or Welfare Benefits, unless such
     reductions are made proportionally for all executives of the Company at the
     same time.

     (k) "Limitation Amount" shall mean the sum of Payments that constitute
nondeductible "excess parachute payments" under section 280G of the Internal
Revenue Code of 1986, as amended (the "Code"), assuming such Payments constitute
the only payments made on account of a Change in Control, that result in a
deemed Federal income tax cost to the Company, calculated as set forth in the
succeeding sentences, of $15,000,000. The Limitation Amount is based on the
estimated Federal income tax cost to the Company resulting from the
nondeductibility of such excess parachute payments, which tax cost shall not
exceed $15,000,000. The initial Limitation Amount is $42,857,143.07, based on
the Federal corporate income tax rate of 35% for tax years ending in 2001. The
Limitation Amount shall be adjusted if, and when, the Federal corporate income
tax rate changes to such amount as shall equal the quotient obtained by dividing
$15,000,000 by such changed Federal corporate income tax rate; provided,
however, that the Limitation Amount shall not be so adjusted after the first
Change in Control to occur after April 1, 2001.

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     (l) "Payment" shall mean any payment or transfer by the Company under this
Agreement to or for the benefit of the Executive (including for this purpose
those made pursuant to Section 3(a)(iii)) or, as the case may be, any such
payment or transfer made to another executive officer of the Company pursuant to
another Employment Agreement. "Payment" shall not include any amount that would
be payable to the Executive or another executive officer of the Company that
would be payable in the event of a Change in Control regardless of the existence
of this Agreement or the relevant Employment Agreement, as the case may be. By
way of example, an amount in respect of an option that by its terms, and not
pursuant to the terms of this Agreement, accelerates upon a Change in Control
shall not be deemed to be a Payment.

     (m) "Subsidiary" shall mean any other entity, whether incorporated or
unincorporated, in which the Company or any one or more of its Subsidiaries
directly owns or controls (i) 50% or more of the securities or other ownership
interests, including profits, equity or beneficial interests, or (ii) securities
or other interests having by their terms ordinary voting power to elect more
than 50% of the board of directors or others performing similar function with
respect to such other entity that is not a corporation.

     (n) "Target Bonus" shall mean the Executive's target bonus under the
Company's annual bonus program, or any comparable bonus under any predecessor or
successor plan for the year prior to the year in which the Change in Control or,
in the case of a termination other than on account of a Change in Control, the
Date of Termination occurs.

     (o) "Units" shall mean the restricted stock units that entitle Executive to
receive shares of common stock of the Company awarded to Executive as of the
date of this Agreement.

     (p) "Welfare Benefits" shall mean welfare benefit plans, practices,
policies and programs provided by the Company and its affiliated companies
(including, without limitation, medical, prescription, dental, vision,
disability, employee life, and group life plans and programs) (i) in effect for
the Executive at any time during the 120-day period immediately preceding (A)
the Change in Control or (B) the Date of Termination (as defined below) or (ii)
which are provided at any time after the Change in Control to peer executives of
the Company and its affiliated companies, whichever of (i)(A), (i)(B) or (ii)
provides the most favorable benefit to the Executive, as determined separately
for each such benefit.

     SECTION 2. TERMINATION OF EMPLOYMENT DURING THE EMPLOYMENT PERIOD.

     (a) Death or Disability. The Executive's employment shall terminate
         -------------------
automatically upon the Executive's death during the Employment Period or Change
in Control Employment Period. If the Company determines in good faith that the
Disability of the Executive has occurred during the Employment Period or Change
in Control Employment Period, it may give to the Executive written notice in
accordance with Section 9(b) of this Agreement of its intention to terminate the
Executive's employment. In such event, the Executive's employment with the
Company shall terminate effective on the 30th day after receipt of such notice
by the Executive (the "Disability Effective Date"), provided that, within the 30
days after such receipt, the Executive shall not have returned to full-time
performance of the Executive's duties.

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     (b) Cause. The Company may terminate the Executive's employment for Cause
         -----
during the Employment Period or Change in Control Employment Period.

     (c) Good Reason. The Executive's employment may be terminated by the
         -----------
Executive for Good Reason during the Employment Period.


     (d) Change in Control Good Reason. The Executive's employment may be
         -----------------------------
terminated by the Executive for Change in Control Good Reason during the Change
in Control Employment Period. For purposes of this Section 2(d), any good faith
determination of "Change in Control Good Reason" made by the Executive shall be
conclusive. The termination of the Executive's employment with the Company prior
to, but in anticipation of or in connection with, a Change in Control shall be
deemed to be a termination by the Executive for Change in Control Good Reason
during the Change in Control Employment Period if the Board so determines in its
good faith judgment.

     (e) Notice of Termination. Any termination by the Company for Cause, or by
         ---------------------
the Executive for Good Reason during the Employment Period or for Change in
Control Good Reason during the Change in Control Employment Period, shall be
communicated by Notice of Termination to the other party hereto given in
accordance with Section 9(b) of this Agreement. For purposes of this Agreement,
a "Notice of Termination" means a written notice which (i) indicates the
specific termination provision in this Agreement relied upon, (ii) to the extent
applicable, sets forth in reasonable detail the facts and circumstances claimed
to provide a basis for termination of the Executive's employment under the
provision so indicated and (iii) if the Date of Termination (as defined below)
is other than the date of receipt of such notice, specifies the termination date
(which date shall be not more than 30 days after the giving of such notice). The
failure by the Executive or the Company to set forth in the Notice of
Termination any fact or circumstance which contributes to a showing of Good
Reason, Change in Control Good Reason or Cause shall not waive any right of the
Executive or the Company, respectively, hereunder or preclude the Executive or
the Company, respectively, from asserting such fact or circumstance in enforcing
the Executive's or the Company's rights hereunder.

     (f) Date of Termination. "Date of Termination" means (i) if the Executive's
         -------------------
employment is terminated by the Company for Cause, by the Executive for Good
Reason during the Employment Period, or by the Executive for Change in Control
Good Reason during the Change in Control Employment Period, the date of receipt
of the Notice of Termination or any later date specified therein, as the case
may be, (ii) if the Executive's employment is terminated by the Company other
than for Cause or Disability or by the Executive other than Good Reason or
Change in Control Good Reason, the Date of Termination shall be the date on
which the Company or the Executive, as the case may be, notifies the other of
such termination, and (iii) if the Executive's employment is terminated by
reason of death or Disability, the Date of Termination shall be the date of
death of the Executive or the Disability Effective Date, as the case may be.

     SECTION 3. OBLIGATIONS OF THE COMPANY UPON TERMINATION

     (a) Termination During the Change in Control Employment Period for Change
         ---------------------------------------------------------------------
in Control Good Reason or Other Than for Cause, Death or Disability. If, during
-------------------------------------------------------------------
the Change in



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Control Employment Period, the Company shall terminate the Executive's
employment other than for Cause or the Executive shall terminate employment for
Change in Control Good Reason (and the Executive's employment is not terminated
by reason of death or Disability):

          (i) The Company shall pay to the Executive the aggregate of the
     following amounts:

              (A) the sum of (1) the Executive's Annual Base Salary through the
          Date of Termination to the extent not theretofore paid, (2) the
          product of (x) the Target Bonus and (y) a fraction, the numerator of
          which is the number of days in the current fiscal year through the
          Date of Termination, and the denominator of which is 365 and (3) any
          compensation previously deferred by the Executive (together with any
          accrued interest or earnings thereon) and any accrued vacation pay, in
          each case to the extent not theretofore paid (the sum of the amounts
          described in clauses (1), (2), and (3) shall be hereinafter referred
          to as the "Accrued Obligations"); and

              (B) the amount equal to the product of (1) two and (2) the sum of
          (x) the Executive's Annual Base Salary and (y) the Target Bonus or, if
          greater, the bonus pursuant to the Company's management bonus plan in
          the most recently completed fiscal year.

     The payments described in this Section 3(a)(i) shall be paid to the
Executive in a lump sum in cash within 30 days after the Date of Termination
unless the Executive elected to receive such payments in equal installments in
accordance with the Company's usual payroll practices over the 24-month period
following the Date of Termination. Such election may be made at any time prior
to the Change in Control and may be amended or revoked at the sole discretion of
the Executive prior to the date of the Change in Control.

          (ii) For 24 months after the Executive's Date of Termination, or such
     longer period as may be provided by the terms of the appropriate plan,
     program, practice or policy, the Company shall continue Welfare Benefits to
     the Executive and/or the Executive's family; provided, however, that if the
     Executive becomes reemployed with another employer and is eligible to
     receive medical or other welfare benefits under another employer provided
     plan, the medical and other welfare benefits described herein shall be
     secondary to those provided under such other plan during such applicable
     period of eligibility. For purposes of determining eligibility (but not the
     time of commencement of benefits) of the Executive for retiree benefits
     pursuant to such plans, practices, programs and policies, the Executive
     shall be considered to have remained employed until 24 months after the
     Executive's Date of Termination and to have retired on the last day of such
     period;

          (iii) All options acquired under the 1991 Stock Plan of Incyte
     Genomics, Inc. or any other stock-based incentive plan of the Company which
     have not vested in accordance with the terms and conditions of the grant,
     award or purchase, shall become 100% vested and all options shall continue
     to be exercisable for 12 months following the Date of Termination and all
     Units shall become 100% vested and the shares of common

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     stock of the Company shall be delivered to the Executive within 30 days
     after the Date of Termination;

          (iv) The Company shall, at its sole expense as incurred, provide the
     Executive with outplacement services for a period of 12 months following
     the Date of Termination, the scope and provider of which shall be selected
     by the Executive in his sole discretion (the "Outplacement Benefits"); and

          (v)  To the extent not theretofore paid or provided, the Company shall
     timely pay or provide to the Executive any other amounts or benefits
     required to be paid or provided or which the Executive is eligible to
     receive under any plan, program, policy or practice or contract or
     agreement of the Company and its affiliated companies (such other amounts
     and benefits shall be hereinafter referred to as the "Other Benefits").

     (b) Termination During the Employment Period for Good Reason or Other Than
         ----------------------------------------------------------------------
for Cause, Death or Disability. If, during the Employment Period, the Company
------------------------------
shall terminate the Executive's employment other than for Cause or the Executive
shall terminate employment for Good Reason (and the Executive's employment is
not terminated by reason of death or Disability):

          (i)  The Company shall pay to the Executive the aggregate of the
     following amounts:

               (A) The Accrued Obligations; and

               (B) the amount equal to the product of (1) one and (2) the sum of
          (x) the Executive's Annual Base Salary and (y) the Target Bonus or, if
          greater, the bonus pursuant to the Company's management bonus plan in
          the most recently completed fiscal year.

          The payments described in this Section 3(b)(i) shall be paid to the
     Executive in a lump sum in cash within 30 days after the Date of
     Termination unless the Executive elected to receive such payments in equal
     installments in accordance with the Company's usual payroll practices over
     the 12-month period following the Date of Termination. Such election may be
     made at any time prior to 180 days before the Date of Termination and may
     be amended or revoked at the sole discretion of the Executive prior to 180
     days before the Date of Termination.

          (ii)  For 12 months after the Executive's Date of Termination, the
     Company shall continue Welfare Benefits to Executive and/or the Executive's
     family; provided, however, that if the Executive becomes reemployed with
     another employer and is eligible to receive medical or other welfare
     benefits under an other employer provided plan, the medical and other
     welfare benefits described herein shall be secondary to those provided
     under such other plan during such applicable period of eligibility. For
     purposes of determining eligibility (but not the time of commencement of
     benefits) of the Executive for retiree benefits pursuant to such plans,
     practices, programs and policies, the Executive shall be considered to have
     remained employed until 12 months after the Executive's Date of Termination
     and to have retired on the last day of such period.

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          (iii) An additional portion of options acquired under the 1991 Stock
     Plan of Incyte Genomics, Inc. or any other stock-based incentive plan of
     the Company which have not vested in accordance with the terms and
     conditions of the grant, award or purchase, shall become vested equal to
     the amount of vesting that would have occurred if the Executive had
     continued working for the Company for an additional 12 months after the
     Date of Termination and all options shall continue to be exercisable for 12
     months following the Date of Termination and an additional portion of the
     Units which have not vested in accordance with the terms and conditions of
     such grant shall become vested equal to the amount of vesting that would
     have occurred if the Executive had continued working for the Company for an
     additional 12 months after the Date of Termination (provided that, in any
     event, an additional portion equal to at least 33% of the Units shall
     become vested) and the shares of common stock of the Company shall be
     delivered to the Executive within 30 days after the Date of Termination.

          (iv)  The Company shall provide to the Executive the Outplacement
     Benefits and the Other Benefits.

     (c) Termination for Cause. If the Executive's employment shall be
         ---------------------
terminated for Cause during the Employment Period or the Change in Control
Employment Period, this Agreement shall terminate without further obligations to
the Executive other than the obligation to pay to the Executive (x) the
Executive's Annual Base Salary through the Date of Termination, (y) the amount
of any compensation previously deferred by the Executive, including vested
Units, and (z) Other Benefits; provided that if such termination occurs during
the Employment Period, the Executive shall not receive a prorated Target Bonus,
in each case to the extent theretofore unpaid. In such case, all amounts due and
owing to the Executive pursuant to this Section 3(c) shall be paid to the
Executive in a lump sum in cash or, in the case of vested Units, in shares of
common stock of the Company, within 30 days of the Date of Termination.

     (d) Voluntary Termination. If the Executive voluntarily terminates
         ---------------------
employment during the Employment Period other than for Good Reason, or during
the Change in Control Employment Period, other than for Change in Control Good
Reason, this Agreement shall terminate without further obligations to the
Executive other than for Accrued Obligations and the timely payment or provision
of Other Benefits; provided that if such termination occurs during the
Employment Period, the Executive shall not receive a prorated Target Bonus. In
such case, all amounts due and owing to the Executive pursuant to this Section
3(d) shall be paid to the Executive in a lump sum in cash or, in the case of
vested Units, in shares of common stock of the Company, within 30 days of the
Date of Termination.

     (e) Death or Disability. If the Executive's employment is terminated during
         -------------------
the Employment Period or the Change in Control Employment Period due to the
death or Disability of the Executive, this Agreement shall terminate without
further obligations to the Executive other than for (i) Accrued Obligations and
the timely payment or provision of Other Benefits, (ii) an additional portion of
options acquired under the 1991 Stock Plan of Incyte Genomics, Inc. or any other
stock-based incentive plan of the Company which have not vested in accordance
with the terms and conditions of the grant, award or purchase, shall become
vested equal to the amount of vesting that would have occurred if the Executive
had continued working for the Company for an additional 12 months after the Date
of Termination and all options shall

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continue to be exercisable for 12 months following the Date of Termination, and
(iii) should such death or Disability occur prior to November 26, 2003, 33% of
the Units shall become vested or, should such death or Disability occur on or
after November 26, 2003, 100% of the Units shall become vested. In such case,
all amounts due and owing to the Executive or the Executive's estate, as the
case may be, pursuant to this Section 3(e) shall be paid to the Executive or the
Executive's estate in a lump sum in cash or, in the case of vested Units, in
shares of common stock of the Company, within 30 days of the receipt by the
Company of written notice of the Executive's death from the executor of the
Executive's estate or the Disability Effective Date.

     SECTION 4. SECTION 280G.

     (a) Basic Rule. Notwithstanding anything in this Agreement to the contrary,
         ----------
in the event that the independent auditors most recently selected by the Board
(the "Auditors") determine that any Payments would constitute "excess parachute
payments" within the meaning of section 280G of the Code that in the aggregate
exceed the Limitation Amount, then the Payments made pursuant to this Agreement
shall be reduced (but not below zero) to the Reduced Amount. For purposes of
this Section 4, the "Reduced Amount" shall be the amount, expressed as a present
value, that maximizes the aggregate present value of the Payments to the
Executive without causing the sum of the Payments made hereunder and under all
Employment Agreements to exceed the Limitation Amount. The Payments for the
Executive under this Agreement and for each executive officer under the other
Employment Agreements, as so reduced, shall be determined on a pro rata basis
based on the total Payments payable pursuant to the Employment Agreements,
calculated as of the date of the first Change in Control to occur after April 1,
2001. Notwithstanding anything contained in this Agreement to the contrary, to
the extent that any payment or distribution of any type to or for the benefit of
the Executive by the Company (the "Total Payment") is or will be subject to the
excise tax imposed under Section 4999 of the Code (the "Excise Tax"), then the
Total Payments shall be reduced (but not below zero) if and to the extent that a
reduction in the Total Payments would result in the Executive retaining a larger
amount, on an after-tax basis (taking into account federal, state and local
income taxes and the Excise Tax) than if the Executive received the entire
amount of such Total Payments. The determination of which Payments are to be
reduced shall be made in a manner consistent with the provisions of Section
4(b).

     (b) Reduction of Payments. If the Auditors determine that any Payments made
         ---------------------
pursuant to this Agreement would exceed the Limitation Amount because of section
280G of the Code, which calculation shall occur at the time of the Change in
Control, then the Company shall promptly give the Executive notice to that
effect and a copy of the detailed calculation thereof and of the Reduced Amount,
and the Executive may then elect, in the Executive's sole discretion, which and
how much of such Payments shall be eliminated or reduced (as long as after such
election the aggregate present value of such Payments, as so eliminated or
reduced, equals the Reduced Amount) and shall advise the Company in writing of
the Executive's election within 10 days of receipt of notice. If no such
election is made by the Executive within such 10-day period, then the Company
may decide which and how much of such Payments shall be eliminated or reduced
(as long as after such decision the aggregate present value of such Payments, as
so eliminated or reduced, equals the Reduced Amount) and shall notify the
Executive promptly of such decision. For purposes of this Section 4, present
value shall be determined in accordance with section 280G(d)(4) of the Code. All
determinations made by the

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Auditors under this Section 4 shall be binding upon the Company and the
Executive and shall be made within 60 days of the date when a Payment becomes
payable or transferable. As promptly as practicable following such determination
and the elections hereunder, the Company shall pay or transfer to or for the
benefit of the Executive such amounts as are then due to the Executive under
this Agreement and shall promptly pay or transfer to or for the benefit of the
Executive in the future such amounts as become due to the Executive under this
Agreement.

     (c) Overpayments and Underpayments. As a result of uncertainty in the
         ------------------------------
application of section 280G of the Code at the time of an initial determination
by the Auditors hereunder, it is possible that Payments will have been made by
the Company pursuant to this Agreement that should not have been made (an
"Overpayment") or that additional Payments that will not have been made by the
Company pursuant to this Agreement could have been made (an "Underpayment"),
consistent in each case with the calculation of the Reduced Amount hereunder. In
the event that the Auditors, based upon the assertion of a deficiency by the
Internal Revenue Service against the Company or the Executive that the Auditors
believe has a high probability of success, determine that an Overpayment has
been made, such Overpayment shall be treated for all purposes as a loan to the
Executive which he or she shall repay to the Company, together with interest at
the applicable federal rate provided in section 7872(f)(2) of the Code;
provided, however, that no amount shall be payable by the Executive to the
Company if and to the extent that such payment would not reduce the Company's
Federal income tax liability under section 280G of the Code. In the event that
the Auditors determine that an Underpayment has occurred, such Underpayment
shall promptly be paid or transferred by the Company to or for the benefit of
the Executive, together with interest at the applicable federal rate provided in
section 7872(f)(2) of the Code.

     (d) Waiver of Limitation. At any time, and in its sole discretion, the
         --------------------
Company's Compensation Committee of the Board may elect to waive, in whole or in
part, the reduction of a Payment to be made pursuant to this Agreement,
notwithstanding the determination that such Payment will be nondeductible by the
Company for federal income tax purposes because of section 280G of the Code, or
that it exceeds the Limitation Amount.

     (e) Related Corporations. For purposes of this Section 4, the term
         --------------------
"Company" shall include affiliated corporations to the extent determined by the
Auditors in accordance with section 280G(d)(5) of the Code.

     SECTION 5. NON-EXCLUSIVITY OF RIGHTS.

     Nothing in this Agreement shall prevent or limit the Executive's continuing
or future participation in any plan, program, policy or practice provided by the
Company or any of its affiliated companies and for which the Executive may
qualify, nor, subject to Section 9(f), shall anything herein limit or otherwise
affect such rights as the Executive may have under any contract or agreement
with the Company or any of its affiliated companies. Amounts which are vested
benefits or which the Executive is otherwise entitled to receive under any plan,
policy, practice or program of or any contract or agreement with the Company or
any of its affiliated companies at or subsequent to the Date of Termination
shall be payable in accordance with such plan, policy, practice or program or
contract or agreement except as explicitly modified by this Agreement.

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<PAGE>

     SECTION 6. FULL SETTLEMENT.

     The Company's obligation to make the payments provided for in this
Agreement and otherwise to perform its obligations hereunder shall not be
affected by any set-off, counterclaim, recoupment, defense or other claim, right
or action which the Company may have against the Executive or others (other than
pursuant to Section 7(c) of this Agreement). In no event shall the Executive be
obligated to seek other employment or take any other action by way of mitigation
of the amounts payable to the Executive under any of the provisions of this
Agreement and such amounts shall not be reduced whether or not the Executive
obtains other employment. The Company agrees to pay as incurred, to the full
extent permitted by law, all legal fees and expenses which the Executive may
reasonably incur as a result of any contest (regardless of the outcome thereof)
by the Company, the Executive or others of the validity or enforceability of, or
liability under, any provision of this Agreement or any guarantee of performance
thereof (including as a result of any contest by the Executive about the amount
of any payment pursuant to this Agreement), plus in each case interest on any
delayed payment at the applicable Federal rate provided for in section
7872(f)(2)(A) of the Code. Notwithstanding the foregoing, the Company will not
pay any legal fees or expenses which the Executive may incur as a direct result
of any contest or dispute regarding Sections 7(a) or 7(b) of this Agreement;
provided, however, that (i) this sentence shall not apply if (A) after a Change
in Control the Executive's employment with the Company is terminated by the
Company without Cause, by the Executive for Change in Control Good Reason or by
the Executive for Good Reason under subparagraph (v) thereof and (B) the
Executive has not, in the good faith determination of the Board, blatantly and
willfully breached Sections 7(a) or 7(b) of this Agreement and (ii) if this
sentence applies and there is a contest or dispute regarding Sections 7(a) or
7(b) of this Agreement and the Executive is found to have not violated Section 7
of this Agreement, then the Company will reimburse all such legal fees and
expenses reasonably incurred as a result of such contest or dispute.

     SECTION 7. COVENANTS.

     (a) During the Executive's employment with the Company and for two (2)
years after the termination of the Executive's employment for any reason, the
Executive agrees that, without the prior express written consent of the Company,
the Executive shall not, anywhere in the world, for his own benefit or for, with
or through any other person, firm, partnership, corporation or other entity or
individual (other than the Company or its affiliates) as or in the capacity of
an owner, shareholder, employee, consultant, director, officer, trustee,
partner, agent, independent contractor and/or in any other representative
capacity or otherwise:

          (i) directly or indirectly, induce or attempt to induce any employee
     of the Company or its subsidiaries to terminate his or her employment with
     the Company for the purpose of accepting employment with any employer other
     than the Company, its subsidiaries, or an entity formed by or with the
     participation of the Company (provided that in the case of any such entity
     formed by or with the participation of the Company the hiring of any such
     employee by such entity is approved, either on an individual employee basis
     or a general basis by which it is acknowledged that such entity may hire
     employees of the Company or its subsidiaries, by the Company's Board of
     Directors or Chief Executive Officer), nor, during the two (2) year period
     following the termination of

                                     - 12 -


<PAGE>

     Executive's employment, directly or indirectly hire (A) any employee of the
     Company or its subsidiaries at the time of such hiring or (B) any former
     employee of the Company or its subsidiaries who had such relationship
     within six (6) months prior to the date of such hiring, it being understood
     that nothing herein shall prohibit the Executive from serving as and
     providing a reference for any such employee or former employee;

          (ii)  personally (or personally direct another to) make or publish any
     statement (orally or in writing) to a current or prospective client of the
     Company or its affiliates or any other entity with whom the Company has a
     collaboration, strategic partnership, joint venture or other similar
     relationship (collectively, a "Customer Entity") that would libel, slander,
     disparage, denigrate, ridicule or criticize the Company or any of its
     affiliates; and

          (iii) personally (or personally direct another to) solicit any
     Customer Entity to purchase a gene sequence or genomic database product
     competitive with such a product marketed by or under development at or for
     the Company.

     (b) The Executive shall hold in a fiduciary capacity for the benefit of the
Company all secret or confidential information, knowledge or data relating to
the Company or any of its affiliated companies, and their respective businesses,
which shall have been obtained by the Executive during the Executive's
employment by the Company or any of its affiliated companies and which shall not
be or become public knowledge (other than by acts by the Executive or
representatives of the Executive in violation of this Agreement). After
termination of the Executive's employment with the Company, the Executive shall
not, without the prior written consent of the Company or as may otherwise be
required by law or legal process, communicate or divulge any such information,
knowledge or data to anyone other than the Company and those designated by it.
In no event shall an asserted violation of the provisions of this Section 7
constitute a basis for deferring or withholding any amounts otherwise payable to
the Executive under this Agreement. The Executive also agrees to comply with the
terms set forth in the Confidential Information and Invention Assignment
Agreement between the Executive and the Company (the "Confidential Information
Agreement").

     (c) If at any time prior to the date that is 365 days after the Executive's
Date of Termination, the Executive breaches any provision of Sections 7(a) or
7(b) of this Agreement in more than a minor, de minimis or trivial manner, then
(i) the Executive shall forfeit all of the Executive's unvested Units and (ii)
the gain or income realized within the twenty-four (24) months prior to such
breach from the vesting of Units by the Executive shall be paid by the Executive
to the Company upon notice from the Company (for purposes of this Section 7(c),
the vesting of Units shall be treated as a realization event). Such gain shall
be determined on a gross basis, without reduction for any taxes incurred, as of
the date of such event, and without regard to any subsequent change in the Fair
Market Value (as defined below) of a share of Company common stock. The Company
shall have the right to offset such gain against any amounts otherwise owed to
the Executive by the Company (whether as wages, vacation pay, or pursuant to any
benefit plan or other compensatory arrangement). For purposes of this Section
7(c), the "Fair Market Value" of a share of Company common stock on any date
shall be (i) the closing price per share of Company common stock during normal
trading hours on the national securities exchange on which the Company common
stock is principally traded for such date or the last preceding date on which
there was a sale of such Company common stock on such exchange, as

                                     - 13 -


<PAGE>

reported by the applicable composite-transactions report, (ii) if the shares of
Company common stock are then traded on The Nasdaq Stock Market, the last
reported sale price per share of Company common stock during normal trading
hours as reported for such date on The Nasdaq Stock Market, or (iii) if the
shares of Company common stock are traded over-the-counter on such date but not
on The Nasdaq Stock Market, the last transaction price per share of Company
common stock quoted for such date by the OTC Bulletin Board or, if not so
quoted, the mean between the last reported representative bid and asked prices
for the shares of Company common stock quoted for such date by the principal
automated inter-dealer quotation system on which the shares of Company common
stock are quoted or, if the Company common stock is not quoted on any such
system, by the "Pink Sheets" published by the National Quotation Bureau, Inc.,
or (iii) if the shares of Company common stock are not then listed on a national
securities exchange or traded in an over-the-counter market, such value as the
Compensation Committee of the Board shall determine in good faith.
Notwithstanding the foregoing, this Section 7(c) shall not apply in the event
that after a Change in Control the Executive's employment with the Company is
terminated either (i) by the Company without Cause or (ii) by the Executive for
Change in Control Good Reason.

     (d) Any termination of the Executive's employment or of this Agreement
shall have no effect on the continuing operation of this Section 7.

     (e) The Executive acknowledges and agrees that the Company will have no
adequate remedy at law, and could be irreparably harmed, if the Executive
breaches or threaten to breach any of the provisions of this Section 7. The
Executive agrees that the Company shall be entitled to equitable and/or
injunctive relief to prevent any breach or threatened breach of this Section 7,
and to specific performance of each of the terms hereof in addition to any other
legal or equitable remedies that the Company may have. The Executive further
agrees that he shall not, in any equity proceeding relating to the enforcement
of the terms of this Section 7, raise the defense that the Company has an
adequate remedy at law.

     (f) The terms and provisions of this Section 7 are intended to be separate
and divisible provisions and if, for any reason, any one or more of them is held
to be invalid or unenforceable, neither the validity nor the enforceability of
any other provision of this Agreement shall thereby be affected. The parties
hereto acknowledge that the potential restrictions on the Executive's future
employment imposed by this Section 7 are reasonable in both duration and
geographic scope and in all other respects. If for any reason any court of
competent jurisdiction shall find any provisions of this Section 7 unreasonable
in duration or geographic scope or otherwise, the Executive and the Company
agree that the restrictions and prohibitions contained herein shall be effective
to the fullest extent allowed under applicable law in such jurisdiction.

     (g) The parties acknowledge that this Agreement would not have been entered
into and the benefits described herein, including the award of the Units, would
not have been promised in the absence of the Executive's promises under this
Section 7.

     SECTION 8. SUCCESSORS.

     (a) This Agreement is personal to the Executive and without the prior
written consent of the Company shall not be assignable by the Executive
otherwise than by will or the laws of

                                     - 14 -


<PAGE>

descent and distribution. This Agreement shall inure to the benefit of and be
enforceable by the Executive's legal representatives.

     (b) This Agreement shall inure to the benefit of and be binding upon the
Company and its successors and assigns.

     (c) The Company will require any successor (whether direct or indirect, by
purchase, merger, consolidation or otherwise) to all or substantially all of the
business and/or assets of the Company or the relevant Business Unit to assume
expressly and agree to perform this Agreement in the same manner and to the same
extent that the Company or such Business Unit would be required to perform it if
no such succession had taken place. As used in this Agreement, "Company" shall
mean the Company as hereinbefore defined and any successor to its business
and/or assets as aforesaid which assumes and agrees to perform this Agreement by
operation of law, or otherwise.

     SECTION 9. MISCELLANEOUS.

     (a) This Agreement shall be governed by and construed in accordance with
the laws of the State of Delaware without reference to principles of conflict of
laws. The captions of this Agreement are not part of the provisions hereof and
shall have no force or effect. This Agreement may not be amended or modified
otherwise than by a written agreement executed by the parties hereto or their
respective successors and legal representatives.

     (b) All notices and other communications hereunder shall be in writing and
shall be given by hand delivery to the other party or by registered or certified
mail, return receipt requested, postage prepaid, addressed as follows:

         If to the Executive:
         at the Executive's current address as shown on the records of the
         Company.

         If to the Company:
         Incyte Genomics, Inc.
         3160 Porter Drive
         Palo Alto, CA 94304
         Attention:  General Counsel

or to such other address as either party shall have furnished to the other in
writing in accordance herewith. Notice and communications shall be effective
when actually received by the addressee.

     (c) The invalidity or unenforceability of any provision of this Agreement
shall not affect the validity or enforceability of any other provision of this
Agreement.

     (d) The Company may withhold from any amounts payable under this Agreement
such Federal, state, local or foreign taxes as shall be required to be withheld
pursuant to any applicable law or regulation.

                                     - 15 -

<PAGE>

     (e) The Executive's or the Company's failure to insist upon strict
compliance with any provision of this Agreement or the failure to assert any
right the Executive or the Company may have hereunder, including, without
limitation, the right of the Executive to terminate employment for Good Reason
pursuant to Section 2(c) or Change in Control Good Reason pursuant to Section
2(d) of this Agreement, shall not be deemed to be a waiver of such provision or
right or any other provision or right of this Agreement.

     (f) The Executive and the Company acknowledge that, except as may otherwise
be provided under any other written agreement between the Executive and the
Company, the employment of the Executive by the Company is "at will" and, prior
to the Change in Control, the Executive's employment and/or this Agreement may
be terminated by either the Executive or the Company at any time, in which case
the Executive shall have no further rights under this Agreement except as
expressly set forth in Section 3 hereof. From and after the closing of a Change
in Control transaction, this Agreement shall supersede any other agreement
between the parties with respect to the subject matter hereof (provided that it
shall not supersede the Executive's obligations under the Confidential
Information Agreement).

     IN WITNESS WHEREOF, the Executive and the Company, through its duly
authorized Officer, have executed this Agreement to be effective as of the day
and year first above written.

                                    EXECUTIVE

                                    /s/ John M. Vuko
                                    ------------------------------------------

                                    COMPANY

                                    By /s/ Paul Friedman
                                      ----------------------------------------
                                    Its Chief Executive Officer
                                        --------------------------------------



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