EXHIBIT 15.8



NOTIFICATION OF TRANSACTIONS OF DIRECTORS, PERSONS DISCHARGING MANAGERIAL RESPONSIBILITY OR CONNECTED
PERSONS



This form is intended for use by an
issuer to make a RIS notification required by DR 3.1.4R(1).



|(1) | An issuer making a notification in respect of a transaction relating to the shares or debentures of the issuer should complete boxes 1 to 16, 23 and 24.
|--- | --------------------------------------------------------------------------------------------------------------------------------------------------------



|(2) | An issuer making a notification in respect of a derivative relating the shares of the issuer should complete boxes 1 to 4, 6, 8,13, 14, 16, 23 and 24.
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------------



|(3) | An issuer making a notification in respect of options granted to a director/person discharging managerial responsibilities should complete boxes 1 to 3 and 17 to 24.
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(4) | An issuer making a notification in respect of a financial instrument relating to the shares of the issuer (other than a debenture) should complete boxes 1 to 4, 6, 8, 9, 11, 13, 14,
16, 23 and 24.
|--- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



Please complete all relevant boxes should in
block capital letters.



1. Name of the issuer



CAMBRIDGE ANTIBODY TECHNOLOGY GROUP PLC



2. State whether the notification relates to (i) a transaction notified in accordance
with DR 3.1.4R(1)(a); or



(ii) DR 3.1.4(R)(1)(b) a disclosure made in
accordance with section 324 (as extended by section 328) of the Companies Act 1985; or



(iii) both (i) and (ii)



(ii)



3. Name of person discharging managerial responsibilities/director



JOHN STOCKER



4. State whether notification relates to a person connected with a person discharging managerial responsibilities/director named in 3 and identify the connected person



AS IN 3 ABOVE



5. Indicate whether the notification is in respect of a holding of the person referred to in
3 or 4 above or in respect of a non-beneficial interest



AS IN 3 ABOVE



6. Description of shares
(including class), debentures or derivatives or financial instruments relating to shares



ORDINARY 10 PENCE SHARES



7. Name of registered shareholders(s) and, if more than one, the number of shares held by each of them



GREENWOOD NOMINEES LIMITED



---

8. State the nature of the transaction



QUARTERLY PAYMENT OF PART OF DIRECTORS FEES IN LIEU OF CASH CONSIDERATION (SEE NOTES AT 23)



9. Number of shares, debentures or financial instruments
relating to shares acquired



231



10. Percentage of issued class acquired (treasury shares of that class should not be taken
into account when calculating percentage)



0.0004%



11. Number of shares, debentures or financial instruments
relating to shares disposed.



NIL



12. Percentage of issued class disposed (treasury shares of that class should not be taken
into account when calculating percentage)



NIL



13. Price per share or value of transaction



GBP6.76



14. Date and place of transaction



9 FEBRUARY 2006



LONDON



15. Total holding following notification and total percentage holding following notification
(any treasury shares should not be taken into account when calculating percentage)



83,125



0.157%



16. Date issuer informed of transaction



9 FEBRUARY 2006



If a person discharging managerial responsibilities has been granted options by the issuer complete the following boxes



17. Date of grant



18. Period during which or date on which it can be exercised



19. Total amount paid (if any) for grant of the option



20. Description of shares or debentures involved (class and number)



---

21. Exercise price (if fixed at time of grant) or indication that price is to be fixed at the time of exercise



22. Total number of shares or debentures over which options held following
notification



23. Any additional information



THE PRACTICE OF ISSUING SHARES IN LIEU OF PART OF THE BASIC DIRECTORS FEE HAS BEEN
ESTABLISHED BY THE COMPANY FOR SOME TIME. IN NOVEMBER 2004 THE BOARD RESOLVED THAT SUCH ISSUE OF SHARES WOULD OCCUR ON A QUARTERLY RATHER THAN AN ANNUAL BASIS. THE SHARE PRICE USED IS THE AVERAGE CLOSING PRICE OF ONE CAT SHARE FOR THE THREE TRADING
DAYS PRECEDING 9 FEBRUARY 2006



24. Name of contact and telephone number for
queries



JUSTIN HOSKINS, 01223 898589



Name and signature of duly authorised
officer of issuer responsible for making notification



JUSTIN HOSKINS, COMPANY SECRETARY



Date of notification



9 FEBRUARY
2006



END



NOTIFICATION OF TRANSACTIONS OF DIRECTORS, PERSONS
DISCHARGING MANAGERIAL RESPONSIBILITY OR CONNECTED PERSONS



This form is intended for use by an issuer to make a RIS notification required by DR 3.1.4R(1).



|(1) | An issuer making a notification in respect of a transaction relating to the shares or debentures of the issuer should complete boxes 1 to 16, 23 and 24.
|--- | --------------------------------------------------------------------------------------------------------------------------------------------------------



|(2) | An issuer making a notification in respect of a derivative relating the shares of the issuer should complete boxes 1 to 4, 6, 8,13, 14, 16, 23 and 24.
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------------



|(3) | An issuer making a notification in respect of options granted to a director/person discharging managerial responsibilities should complete boxes 1 to 3 and 17 to 24.
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(4) | An issuer making a notification in respect of a financial instrument relating to the shares of the issuer (other than a debenture) should complete boxes 1 to 4, 6, 8, 9, 11, 13, 14,
16, 23 and 24.
|--- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



Please complete
all relevant boxes should in block capital letters.



1. Name of the issuer



CAMBRIDGE ANTIBODY TECHNOLOGY GROUP PLC



2. State whether the notification relates to
(i) a transaction notified in accordance with DR 3.1.4R(1)(a); or



(ii)
DR 3.1.4(R)(1)(b) a disclosure made in accordance with section 324 (as extended by section 328) of the Companies Act 1985; or



(iii) both (i) and (ii)



(ii)



---

3. Name of person discharging managerial responsibilities/director



AKE STAVLING



4. State whether notification relates to a person connected with a person discharging
managerial responsibilities/director named in 3

and identify the connected person



AS IN 3 ABOVE



5. Indicate whether the notification is in respect of a holding of the person referred to in
3 or 4 above or in respect of a non-beneficial interest



AS IN 3 ABOVE



6. Description of shares
(including class), debentures or derivatives or financial instruments relating to shares



ORDINARY 10 PENCE SHARES



7. Name of registered shareholders(s) and, if more than one, the number of shares held by each of them



GREENWOOD NOMINEES LIMITED



8. State the nature of the transaction



QUARTERLY PAYMENT OF PART OF DIRECTORS FEES IN LIEU OF CASH CONSIDERATION (SEE NOTES AT 23)



9. Number of shares, debentures or financial instruments
relating to shares acquired



231



10. Percentage of issued class acquired (treasury shares of that class should not be taken
into account when calculating percentage)



0.0004%



11. Number of shares, debentures or financial instruments
relating to shares disposed.



NIL



12. Percentage of issued class disposed (treasury shares of that class should not be taken
into account when calculating percentage)



NIL



13. Price per share or value of transaction



GBP 6.76



14. Date and place of transaction



1 FEBRUARY 2006



LONDON



15. Total holding following notification and total percentage holding following notification (any treasury shares should not be taken

into account when calculating percentage)



3,281



0.0061%



---

16. Date issuer informed of transaction



9 FEBRUARY 2006



If a person discharging managerial responsibilities has been granted options by the issuer complete the following boxes



17. Date of grant



18. Period during which or date on which it can be exercised



19. Total amount paid (if any) for grant of the option



20. Description of shares or debentures involved (class and number)



21. Exercise price (if fixed at time of grant) or indication that price is to be fixed at the
time of exercise



22. Total number of shares or debentures over which options
held following notification



23. Any additional information



THE PRACTICE OF ISSUING SHARES IN LIEU OF PART OF THE BASIC DIRECTORS FEE HAS BEEN
ESTABLISHED BY THE COMPANY FOR SOME TIME. IN NOVEMBER 2004 THE BOARD RESOLVED THAT SUCH ISSUE OF SHARES WOULD OCCUR ON A QUARTERLY RATHER THAN AN ANNUAL BASIS. THE SHARE PRICE USED IS THE AVERAGE CLOSING PRICE OF ONE CAT SHARE FOR THE THREE TRADING
DAYS PRECEDING 9 FEBRUARY 2006



24. Name of contact and telephone number for
queries



JUSTIN HOSKINS, 01223 898589



Name and signature of duly authorised officer
of issuer responsible for making notification



JUSTIN HOSKINS, COMPANY SECRETARY



Date of notification



9 FEBRUARY
2006



END



---

NOTIFICATION OF TRANSACTIONS OF DIRECTORS, PERSONS DISCHARGING MANAGERIAL RESPONSIBILITY
OR CONNECTED PERSONS



This form is intended
for use by an issuer to make a RIS notification required by DR 3.1.4R(1).



|(1) | An issuer making a notification in respect of a transaction relating to the shares or debentures of the issuer should complete boxes 1 to 16, 23 and 24.
|--- | --------------------------------------------------------------------------------------------------------------------------------------------------------



|(2) | An issuer making a notification in respect of a derivative relating the shares of the issuer should complete boxes 1 to 4, 6, 8,13, 14, 16, 23 and 24.
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------------



|(3) | An issuer making a notification in respect of options granted to a director/person discharging managerial responsibilities should complete boxes 1 to 3 and 17 to 24.
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(4) | An issuer making a notification in respect of a financial instrument relating to the shares of the issuer (other than a debenture) should complete boxes 1 to 4, 6, 8, 9, 11, 13, 14,
16, 23 and 24.
|--- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



Please complete
all relevant boxes should in block capital letters.



1. Name of the issuer



CAMBRIDGE ANTIBODY TECHNOLOGY GROUP PLC



2. State whether the notification relates to
(i) a transaction notified in accordance with DR 3.1.4R(1)(a); or



(ii)
DR 3.1.4(R)(1)(b) a disclosure made in accordance with section 324 (as extended by section 328) of the Companies Act 1985; or



(iii) both (i) and (ii)



(ii)



3. Name of person discharging managerial responsibilities/director



PETER RINGROSE



4. State whether notification relates to a person connected with a person discharging managerial responsibilities/director named in 3 and identify the connected person



AS IN 3 ABOVE



5. Indicate whether the notification is in respect of a holding of the person referred to in
3 or 4 above or in respect of a non-beneficial interest



AS IN 3 ABOVE



6. Description of shares
(including class), debentures or derivatives or financial instruments relating to shares



ORDINARY 10 PENCE SHARES



7. Name of registered shareholders(s) and, if more than one, the number of shares held by each of them



GREENWOOD NOMINEES LIMITED



8. State the nature of the transaction



QUARTERLY PAYMENT OF PART OF DIRECTORS FEES IN LIEU OF CASH
CONSIDERATION (SEE NOTES AT 23)



9. Number of
shares, debentures or financial instruments relating to shares acquired



231



---

10. Percentage of issued class acquired (treasury shares of that class should not be taken into account when calculating
percentage)



0.0004%



11. Number of shares, debentures or financial instruments relating to shares disposed.



NIL



12. Percentage of issued class disposed (treasury shares of that class should not be taken
into account when calculating percentage)



NIL



13. Price per share or value of transaction



GBP 6.76



14. Date and place of transaction



1 FEBRUARY 2006



LONDON



15. Total holding following notification and total percentage holding following notification (any treasury shares should not be taken into account when calculating
percentage)



4,101



0.008%



16. Date issuer informed of transaction



9 FEBRUARY 2006



If a person discharging managerial responsibilities has been
granted options by the issuer complete the following boxes



17. Date of grant



18. Period during which or date on which it can be exercised



19. Total amount paid (if any) for grant of the option



20. Description of shares or debentures involved (class and number)



21. Exercise price (if fixed at time of grant) or indication that price is to be fixed at the
time of exercise



22. Total number of shares or debentures over which options
held following notification



---

23. Any additional information



THE PRACTICE OF ISSUING SHARES IN LIEU OF PART OF THE BASIC DIRECTORS FEE HAS BEEN ESTABLISHED BY THE COMPANY FOR SOME TIME. IN NOVEMBER 2004 THE BOARD RESOLVED THAT
SUCH ISSUE OF SHARES WOULD OCCUR ON A QUARTERLY RATHER THAN AN ANNUAL BASIS. THE SHARE PRICE USED IS THE AVERAGE CLOSING PRICE OF ONE CAT SHARE FOR THE THREE TRADING DAYS PRECEDING 9 FEBRUARY 2006



24. Name of contact and telephone number for queries



JUSTIN HOSKINS, 01223 898589



Name and signature of duly authorised officer of issuer
responsible for making notification



JUSTIN
HOSKINS, COMPANY SECRETARY



Date of
notification



9 FEBRUARY 2006



END



NOTIFICATION OF TRANSACTIONS OF DIRECTORS, PERSONS
DISCHARGING MANAGERIAL RESPONSIBILITY OR CONNECTED PERSONS



This form is intended for use by an issuer to make a RIS notification required by DR 3.1.4R(1).



|(1) | An issuer making a notification in respect of a transaction relating to the shares or debentures of the issuer should complete boxes 1 to 16, 23 and 24.
|--- | --------------------------------------------------------------------------------------------------------------------------------------------------------



|(2) | An issuer making a notification in respect of a derivative relating the shares of the issuer should complete boxes 1 to 4, 6, 8,13, 14, 16, 23 and 24.
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------------



|(3) | An issuer making a notification in respect of options granted to a director/person discharging managerial responsibilities should complete boxes 1 to 3 and 17 to 24.
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(4) | An issuer making a notification in respect of a financial instrument relating to the shares of the issuer (other than a debenture) should complete boxes 1 to 4, 6, 8, 9, 11, 13, 14,
16, 23 and 24.
|--- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



Please complete
all relevant boxes should in block capital letters.



1. Name of the issuer



CAMBRIDGE ANTIBODY TECHNOLOGY GROUP PLC



2. State whether the notification relates to
(i) a transaction notified in accordance with DR 3.1.4R(1)(a); or



(ii)
DR 3.1.4(R)(1)(b) a disclosure made in accordance with section 324 (as extended by section 328) of the Companies Act 1985; or



(iii) both (i) and (ii)



(ii)



3. Name of person discharging managerial responsibilities/director



PROFESSOR CHRISTOPHER MARSHALL



---

4. State whether notification relates to a person connected with a person discharging managerial
responsibilities/director named in 3 and identify the connected person



AS IN 3 ABOVE



5. Indicate whether the
notification is in respect of a holding of the person referred to in 3 or 4 above or in respect of a non-beneficial interest



AS IN 3 ABOVE



6. Description of shares (including class), debentures or derivatives or financial instruments relating to shares



ORDINARY 10 PENCE SHARES



7. Name of registered shareholders(s) and, if more than one,
the number of shares held by each of them



GREENWOOD NOMINEES LIMITED



8. State the nature of the transaction



QUARTERLY PAYMENT OF PART OF DIRECTORS FEES
IN LIEU OF CASH CONSIDERATION (SEE NOTES AT 23)



9. Number of shares,
debentures or financial instruments relating to shares acquired



231



10. Percentage of issued class acquired
(treasury shares of that class should not be taken into account when calculating percentage)



0.0004%



11. Number of shares, debentures or financial instruments relating to shares disposed.



NIL



12. Percentage of issued class disposed (treasury shares of that class should not be taken into account when calculating percentage)



NIL



13. Price per share or value of transaction



GBP 6.76



14. Date and place of transaction



9 FEBRUARY 2006



LONDON



15. Total holding following notification and total percentage holding following notification
(any treasury shares should not be taken

into account when calculating percentage)



1,166



0.0022%



16. Date issuer informed of transaction



9 FEBRUARY 2006



---

If a person discharging managerial responsibilities has been granted options by the
issuer complete the following boxes



17. Date
of grant



18. Period during which or date on which it can be exercised



19. Total amount paid (if any) for grant of the option



20. Description of shares or debentures involved (class and number)



21. Exercise price (if fixed at time of grant) or indication that price is to be fixed at the
time of exercise



22. Total number of shares or debentures over which options
held following notification



23. Any additional information



THE PRACTICE OF ISSUING SHARES IN LIEU OF PART OF THE BASIC DIRECTORS FEE HAS BEEN
ESTABLISHED BY THE COMPANY FOR SOME TIME. IN NOVEMBER 2004 THE BOARD RESOLVED THAT SUCH ISSUE OF SHARES WOULD OCCUR ON A QUARTERLY RATHER THAN AN ANNUAL BASIS. THE SHARE PRICE USED IS THE AVERAGE CLOSING PRICE OF ONE CAT SHARE FOR THE THREE TRADING
DAYS PRECEDING 9 FEBRUARY 2006



24. Name of contact and telephone number for
queries



JUSTIN HOSKINS, 01223 898589



Name and signature of duly authorised officer
of issuer responsible for making notification



JUSTIN HOSKINS, COMPANY SECRETARY



Date of notification



9 FEBRUARY
2006



END



NOTIFICATION OF TRANSACTIONS OF DIRECTORS, PERSONS
DISCHARGING MANAGERIAL RESPONSIBILITY OR CONNECTED PERSONS



This form is intended for use by an issuer to make a RIS notification required by DR 3.1.4R(1).



|(1) | An issuer making a notification in respect of a transaction relating to the shares or debentures of the issuer should complete boxes 1 to 16, 23 and 24.
|--- | --------------------------------------------------------------------------------------------------------------------------------------------------------



|(2) | An issuer making a notification in respect of a derivative relating the shares of the issuer should complete boxes 1 to 4, 6, 8,13, 14, 16, 23 and 24.
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------------



---

|(3) | An issuer making a notification in respect of options granted to a director/person discharging managerial responsibilities should complete boxes 1 to 3 and 17 to 24.
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(4) | An issuer making a notification in respect of a financial instrument relating to the shares of the issuer (other than a debenture) should complete boxes 1 to 4, 6, 8, 9, 11, 13, 14,
16, 23 and 24.
|--- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



Please complete all relevant boxes should in
block capital letters.



1. Name of the issuer



CAMBRIDGE ANTIBODY TECHNOLOGY GROUP PLC



2. State whether the notification relates to (i) a
transaction notified in accordance with DR 3.1.4R(1)(a); or



(ii) DR
3.1.4(R)(1)(b) a disclosure made in accordance with section 324 (as extended by section 328) of the Companies Act 1985; or



(iii) both (i) and (ii)



(ii)



3. Name of person discharging managerial responsibilities/director



DR PAUL NICHOLSON



4. State whether notification relates to a person connected with a person discharging managerial responsibilities/director named in 3

and identify the connected person



AS IN 3 ABOVE



5. Indicate whether the notification is in respect of a holding of the person referred to in 3 or 4 above or in respect of a non-beneficial interest



AS IN 3 ABOVE



6. Description of shares (including class), debentures or
derivatives or financial instruments relating to shares



ORDINARY 10 PENCE SHARES



7. Name of registered shareholders(s) and, if more than one, the number of shares held by each of them



DR PAUL NICHOLSON



8. State the nature of the transaction



QUARTERLY PAYMENT OF PART OF DIRECTORS FEES IN LIEU OF CASH CONSIDERATION (SEE NOTES AT 23)



9. Number of shares, debentures or financial instruments
relating to shares acquired



648



10. Percentage of issued class acquired (treasury shares of that class should not be taken
into account when calculating percentage)



0.001%



11. Number of shares, debentures or financial instruments
relating to shares disposed.



NIL



---

12. Percentage of issued class disposed (treasury shares of that class should not be taken into account when calculating
percentage)



NIL



13. Price per share or value of transaction



GBP 6.76



14. Date and place of transaction



9 FEBRUARY 2006



LONDON



15. Total holding following notification and total percentage holding following notification
(any treasury shares should not be taken into account when calculating percentage)



11,962



0.023%



16. Date issuer informed of transaction



9 FEBRUARY 2006



If a person discharging managerial responsibilities has been granted options by the issuer complete the following boxes



17. Date of grant



18. Period during which or date on which it can be exercised



19. Total amount paid (if any) for grant of the option



20. Description of shares or debentures involved (class and number)



21. Exercise price (if fixed at time of grant) or indication that price is to be fixed at the time of exercise



22. Total number of shares or debentures over which options held following notification



23. Any additional information



THE PRACTICE OF ISSUING SHARES IN LIEU OF PART OF THE BASIC DIRECTORS FEE HAS BEEN
ESTABLISHED BY THE COMPANY FOR SOME TIME. IN NOVEMBER 2004 THE BOARD RESOLVED THAT SUCH ISSUE OF SHARES WOULD OCCUR ON A QUARTERLY RATHER THAN AN ANNUAL BASIS. THE SHARE PRICE USED IS THE AVERAGE CLOSING PRICE OF ONE CAT SHARE FOR THE THREE TRADING
DAYS PRECEDING 9 FEBRUARY 2006



---

24. Name of contact and telephone number for queries



JUSTIN HOSKINS, 01223 898589



Name and signature of duly authorised officer of issuer responsible for making notification



JUSTIN HOSKINS, COMPANY SECRETARY



Date of notification



9 FEBRUARY 2006



END



NOTIFICATION OF TRANSACTIONS OF DIRECTORS, PERSONS
DISCHARGING MANAGERIAL RESPONSIBILITY OR CONNECTED PERSONS



This form is intended for use by an issuer to make a RIS notification required by DR 3.1.4R(1).



|(1) | An issuer making a notification in respect of a transaction relating to the shares or debentures of the issuer should complete boxes 1 to 16, 23 and 24.
|--- | --------------------------------------------------------------------------------------------------------------------------------------------------------



|(2) | An issuer making a notification in respect of a derivative relating the shares of the issuer should complete boxes 1 to 4, 6, 8,13, 14, 16, 23 and 24.
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------------



|(3) | An issuer making a notification in respect of options granted to a director/person discharging managerial responsibilities should complete boxes 1 to 3 and 17 to 24.
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(4) | An issuer making a notification in respect of a financial instrument relating to the shares of the issuer (other than a debenture) should complete boxes 1 to 4, 6, 8, 9, 11, 13, 14,
16, 23 and 24.
|--- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



Please complete
all relevant boxes should in block capital letters.



1. Name of the issuer



CAMBRIDGE ANTIBODY TECHNOLOGY GROUP PLC



2. State whether the notification relates to
(i) a transaction notified in accordance with DR 3.1.4R(1)(a); or



(ii)
DR 3.1.4(R)(1)(b) a disclosure made in accordance with section 324 (as extended by section 328) of the Companies Act 1985; or



(iii) both (i) and (ii)



(ii)



3. Name of person discharging managerial responsibilities/director



PROFESSOR JOHN BROWN



4. State whether notification relates to a person connected with a person discharging managerial responsibilities/director named in 3

and identify the connected person



AS IN 3 ABOVE



5. Indicate whether the notification is in respect of a holding of the person referred to in 3 or 4 above or in respect of a non-beneficial interest



AS IN 3 ABOVE



---

6. Description of shares (including class), debentures or derivatives or financial
instruments relating to shares



ORDINARY 10
PENCE SHARES



7. Name of registered shareholders(s) and, if more than one, the
number of shares held by each of them



GREENWOOD NOMINEES LIMITED



8. State the nature of the transaction



QUARTERLY PAYMENT OF PART OF DIRECTORS FEES
IN LIEU OF CASH CONSIDERATION (SEE NOTES AT 23)



9. Number of shares, debentures or financial instruments relating to shares acquired



231



10. Percentage of issued class acquired (treasury shares of that class should not be taken into account when calculating percentage)



0.0004%



11. Number of shares, debentures or financial instruments relating to shares disposed.



NIL



12. Percentage of issued class disposed (treasury shares of that class should not be taken
into account when calculating percentage)



NIL



13. Price per share or value of transaction



GBP 6.76



14. Date and place of transaction



9 FEBRUARY 2006



LONDON



15. Total holding following notification and total percentage holding following notification
(any treasury shares should not be taken into account when calculating percentage)



278



0.0005%



16. Date issuer informed of transaction



9 FEBRUARY 2006



If a person discharging managerial responsibilities has been granted options by the issuer complete the following boxes



17. Date of grant



18. Period during which or date on which it can be exercised



---

19. Total amount paid (if any) for grant of the option



20. Description of shares or debentures involved (class and number)



21. Exercise price (if fixed at time of grant) or indication that price is to be fixed at the time of exercise



22. Total number of shares or debentures over which options held following notification



23. Any additional information



THE PRACTICE OF ISSUING SHARES IN LIEU OF PART OF THE BASIC DIRECTORS FEE HAS BEEN
ESTABLISHED BY THE COMPANY FOR SOME TIME. IN NOVEMBER 2004 THE BOARD RESOLVED THAT SUCH ISSUE OF SHARES WOULD OCCUR ON A QUARTERLY RATHER THAN AN ANNUAL BASIS. THE SHARE PRICE USED IS THE AVERAGE CLOSING PRICE OF ONE CAT SHARE FOR THE THREE TRADING
DAYS PRECEDING 9 FEBRUARY 2006



24. Name of contact and telephone number for
queries



JUSTIN HOSKINS, 01223 898589



Name and signature of duly authorised officer
of issuer responsible for making notification



JUSTIN HOSKINS, COMPANY SECRETARY



Date of notification



9 FEBRUARY
2006



END



END



---

NOTIFICATION OF TRANSACTIONS OF DIRECTORS, PERSONS DISCHARGING MANAGERIAL RESPONSIBILITY OR CONNECTED PERSONS



This form is intended for use by an issuer to make a RIS
notification required by DR 3.1.4R(1).



|(1) | An issuer making a notification in respect of a transaction relating to the shares or debentures of the issuer should complete boxes 1 to 16, 23 and 24.
|--- | --------------------------------------------------------------------------------------------------------------------------------------------------------



|(2) | An issuer making a notification in respect of a derivative relating the shares of the issuer should complete boxes 1 to 4, 6, 8,13, 14, 16, 23 and 24.
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------------



|(3) | An issuer making a notification in respect of options granted to a director/person discharging managerial responsibilities should complete boxes 1 to 3 and 17 to 24.
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(4) | An issuer making a notification in respect of a financial instrument relating to the shares of the issuer (other than a debenture) should complete boxes 1 to 4, 6, 8, 9, 11, 13, 14,
16, 23 and 24.
|--- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



Please complete
all relevant boxes should in block capital letters.



1. Name of the issuer



CAMBRIDGE
ANTIBODY TECHNOLOGY GROUP PLC



2. State
whether the notification relates to (i) a transaction notified in accordance with DR 3.1.4R(1)(a); or



(ii) DR 3.1.4(R)(1)(b) a disclosure made in accordance with section 324 (as extended by section 328) of the Companies Act 1985; or



(iii) both (i) and (ii)



(ii)



3. Name of person discharging managerial responsibilities/director



JOHN STOCKER



4. State whether notification relates to a person connected with a person discharging managerial responsibilities/director named in 3 and identify the connected person



AS IN 3 ABOVE



5. Indicate whether the notification is in respect of a holding of the person referred to in
3 or 4 above or in respect of a non-beneficial interest



AS IN 3 ABOVE



6. Description of shares (including class), debentures or derivatives or financial instruments relating to shares



ORDINARY 10 PENCE SHARES



7. Name of registered shareholders(s) and, if more than one, the number of shares held by each of them



GREENWOOD NOMINEES LIMITED



8. State the nature of the transaction



QUARTERLY PAYMENT OF PART OF DIRECTORS FEES IN LIEU OF CASH
CONSIDERATION (SEE NOTES AT 23)



9. Number of
shares, debentures or financial instruments relating to shares acquired



231



10. Percentage of issued class acquired
(treasury shares of that class should not be taken into account when calculating percentage)



0.0004%



|11. | Number of shares, debentures or financial instruments relating to shares disposed.
|--- | ----------------------------------------------------------------------------------



NIL



12. Percentage of issued class disposed (treasury shares of that class should not be taken into account when calculating percentage)



NIL



|13. | Price per share or value of transaction
|--- | ---------------------------------------



GBP6.76



|14. | Date and place of transaction
|--- | -----------------------------



9 FEBRUARY 2006



LONDON



15. Total holding following notification and total percentage holding following notification (any treasury shares should not be taken into account when calculating
percentage)



83,125



0.157%



|16. | Date issuer informed of transaction
|--- | -----------------------------------



9 FEBRUARY 2006



If a person discharging managerial responsibilities has been granted options by the issuer complete the following boxes



17. Date of grant



18. Period during which or date on which it can be exercised



19. Total amount paid (if any) for grant of the option



20. Description of shares or debentures involved (class and number)



21. Exercise price (if fixed at time of grant) or indication that price is to be fixed at the
time of exercise



22. Total number of shares or debentures over which options
held following notification



23. Any additional information



THE PRACTICE OF ISSUING SHARES IN LIEU OF PART OF THE BASIC DIRECTORS FEE HAS BEEN
ESTABLISHED BY THE COMPANY FOR SOME TIME. IN NOVEMBER 2004 THE BOARD RESOLVED THAT SUCH ISSUE OF SHARES WOULD OCCUR ON A QUARTERLY RATHER THAN AN ANNUAL BASIS. THE SHARE PRICE USED IS THE AVERAGE CLOSING PRICE OF ONE CAT SHARE FOR THE THREE TRADING
DAYS PRECEDING 9 FEBRUARY 2006



|24. | Name of contact and telephone number for queries
|--- | ------------------------------------------------



JUSTIN HOSKINS, 01223 898589



Name and signature of duly authorised officer of issuer responsible for making notification



JUSTIN HOSKINS, COMPANY SECRETARY



Date of notification



9 FEBRUARY 2006



END



---

NOTIFICATION OF TRANSACTIONS OF DIRECTORS, PERSONS DISCHARGING MANAGERIAL RESPONSIBILITY OR CONNECTED PERSONS



This form is intended for use by an issuer to make a RIS
notification required by DR 3.1.4R(1).



|(1) | An issuer making a notification in respect of a transaction relating to the shares or debentures of the issuer should complete boxes 1 to 16, 23 and 24.
|--- | --------------------------------------------------------------------------------------------------------------------------------------------------------



|(2) | An issuer making a notification in respect of a derivative relating the shares of the issuer should complete boxes 1 to 4, 6, 8,13, 14, 16, 23 and 24.
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------------



|(3) | An issuer making a notification in respect of options granted to a director/person discharging managerial responsibilities should complete boxes 1 to 3 and 17 to 24.
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(4) | An issuer making a notification in respect of a financial instrument relating to the shares of the issuer (other than a debenture) should complete boxes 1 to 4, 6, 8, 9, 11, 13, 14,
16, 23 and 24.
|--- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



Please complete
all relevant boxes should in block capital letters.



1. Name of the issuer



CAMBRIDGE
ANTIBODY TECHNOLOGY GROUP PLC



2. State
whether the notification relates to (i) a transaction notified in accordance with DR 3.1.4R(1)(a); or



(ii) DR 3.1.4(R)(1)(b) a disclosure made in accordance with section 324 (as extended by section 328) of the Companies Act 1985; or



(iii) both (i) and (ii)



(ii)



3. Name of person discharging managerial responsibilities/director



AKE STAVLING



4. State whether notification relates to a person connected with a person discharging managerial responsibilities/director named in 3 and identify the connected person



AS IN 3 ABOVE



5. Indicate whether the notification is in respect of a holding of the person referred to in
3 or 4 above or in respect of a non-beneficial interest



AS IN 3 ABOVE



6. Description of shares (including class), debentures or derivatives or financial instruments relating to shares



ORDINARY 10 PENCE SHARES



7. Name of registered shareholders(s) and, if more than one, the number of shares held by each of them



GREENWOOD NOMINEES LIMITED



8. State the nature of the transaction



QUARTERLY PAYMENT OF PART OF DIRECTORS FEES IN LIEU OF CASH
CONSIDERATION (SEE NOTES AT 23)



9. Number of
shares, debentures or financial instruments relating to shares acquired



231



10. Percentage of issued class acquired
(treasury shares of that class should not be taken into account when calculating percentage)



0.0004%



|11. | Number of shares, debentures or financial instruments relating to shares disposed.
|--- | ----------------------------------------------------------------------------------



NIL



12. Percentage of issued class disposed (treasury shares of that class should not be taken into account when calculating percentage)



NIL



|13. | Price per share or value of transaction
|--- | ---------------------------------------



GBP 6.76



|14. | Date and place of transaction
|--- | -----------------------------



1 FEBRUARY 2006



LONDON



15. Total holding following notification and total percentage holding following notification (any treasury shares should not be taken into account when calculating
percentage)



3,281



0.0061%



|16. | Date issuer informed of transaction
|--- | -----------------------------------



9 FEBRUARY 2006



If a person discharging managerial responsibilities has been granted options by the issuer complete the following boxes



17. Date of grant



18. Period during which or date on which it can be exercised



19. Total amount paid (if any) for grant of the option



20. Description of shares or debentures involved (class and number)



21. Exercise price (if fixed at time of grant) or indication that price is to be fixed at the
time of exercise



22. Total number of shares or debentures over which options
held following notification



23. Any additional information



THE PRACTICE OF ISSUING SHARES IN LIEU OF PART OF THE BASIC DIRECTORS FEE HAS BEEN
ESTABLISHED BY THE COMPANY FOR SOME TIME. IN NOVEMBER 2004 THE BOARD RESOLVED THAT SUCH ISSUE OF SHARES WOULD OCCUR ON A QUARTERLY RATHER THAN AN ANNUAL BASIS. THE SHARE PRICE USED IS THE AVERAGE CLOSING PRICE OF ONE CAT SHARE FOR THE THREE TRADING
DAYS PRECEDING 9 FEBRUARY 2006



|24. | Name of contact and telephone number for queries
|--- | ------------------------------------------------



JUSTIN HOSKINS, 01223 898589



Name and signature of duly authorised officer of issuer responsible for making notification



JUSTIN HOSKINS, COMPANY SECRETARY



Date of notification



9 FEBRUARY 2006



END



---

NOTIFICATION OF TRANSACTIONS OF DIRECTORS, PERSONS DISCHARGING MANAGERIAL RESPONSIBILITY OR CONNECTED PERSONS



This form is intended for use by an issuer to make a RIS
notification required by DR 3.1.4R(1).



|(1) | An issuer making a notification in respect of a transaction relating to the shares or debentures of the issuer should complete boxes 1 to 16, 23 and 24.
|--- | --------------------------------------------------------------------------------------------------------------------------------------------------------



|(2) | An issuer making a notification in respect of a derivative relating the shares of the issuer should complete boxes 1 to 4, 6, 8,13, 14, 16, 23 and 24.
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------------



|(3) | An issuer making a notification in respect of options granted to a director/person discharging managerial responsibilities should complete boxes 1 to 3 and 17 to 24.
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(4) | An issuer making a notification in respect of a financial instrument relating to the shares of the issuer (other than a debenture) should complete boxes 1 to 4, 6, 8, 9, 11, 13, 14,
16, 23 and 24.
|--- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



Please complete
all relevant boxes should in block capital letters.



1. Name of the issuer



CAMBRIDGE
ANTIBODY TECHNOLOGY GROUP PLC



2. State
whether the notification relates to (i) a transaction notified in accordance with DR 3.1.4R(1)(a); or



(ii) DR 3.1.4(R)(1)(b) a disclosure made in accordance with section 324 (as extended by section 328) of the Companies Act 1985; or



(iii) both (i) and (ii)



(ii)



3. Name of person discharging managerial responsibilities/director



PETER RINGROSE



4. State whether notification relates to a person connected with a person discharging managerial responsibilities/director named in 3 and identify the connected person



AS IN 3 ABOVE



5. Indicate whether the notification is in respect of a holding of the person referred to in 3 or 4 above or in respect of a non-beneficial
interest



AS IN 3 ABOVE



6. Description of shares (including class), debentures or derivatives or financial
instruments relating to shares



ORDINARY 10 PENCE SHARES



7. Name of registered shareholders(s) and, if more than one, the number of shares held by
each of them



GREENWOOD NOMINEES LIMITED



8. State the nature of the transaction



QUARTERLY PAYMENT OF PART OF DIRECTORS FEES IN LIEU OF CASH CONSIDERATION (SEE NOTES AT 23)



9. Number of shares, debentures or financial instruments relating to shares
acquired



231



10. Percentage of issued class acquired (treasury shares of that class should not be taken into account when calculating percentage)



0.0004%



11. Number of shares, debentures or financial instruments relating to shares disposed.



NIL



12. Percentage of issued class disposed (treasury shares of that class should not be taken into account when calculating percentage)



NIL



13. Price per share or value of transaction



GBP 6.76



14. Date and place of transaction



1 FEBRUARY 2006



LONDON



15. Total holding following notification and total percentage holding following notification (any treasury shares should not be taken into
account when calculating percentage)



4,101



0.008%



16. Date issuer informed of transaction



9 FEBRUARY 2006



If a person discharging managerial responsibilities has been granted options by the issuer complete the following boxes



17. Date of grant



18. Period during which or date on which it can be exercised



19. Total amount paid (if any) for grant of the option



20. Description of shares or debentures involved (class and number)



21. Exercise price (if fixed at time of grant) or indication that price is to be fixed at the time of exercise



22. Total number of shares or debentures over which options held following notification



23. Any additional information



THE PRACTICE OF ISSUING SHARES IN LIEU OF PART OF THE BASIC DIRECTORS FEE HAS BEEN
ESTABLISHED BY THE COMPANY FOR SOME TIME. IN NOVEMBER 2004 THE BOARD RESOLVED THAT SUCH ISSUE OF SHARES WOULD OCCUR ON A QUARTERLY RATHER THAN AN ANNUAL BASIS. THE SHARE PRICE USED IS THE AVERAGE CLOSING PRICE OF ONE CAT SHARE FOR THE THREE TRADING
DAYS PRECEDING 9 FEBRUARY 2006



24. Name of contact and telephone number for
queries



JUSTIN HOSKINS, 01223 898589



Name and signature of duly authorised officer of issuer
responsible for making notification



JUSTIN
HOSKINS, COMPANY SECRETARY



Date of
notification



9 FEBRUARY 2006



END



---

NOTIFICATION OF TRANSACTIONS OF DIRECTORS, PERSONS DISCHARGING MANAGERIAL RESPONSIBILITY OR CONNECTED PERSONS



This form is intended for use by an issuer to make a RIS
notification required by DR 3.1.4R(1).



|(1) | An issuer making a notification in respect of a transaction relating to the shares or debentures of the issuer should complete boxes 1 to 16, 23 and 24.
|--- | --------------------------------------------------------------------------------------------------------------------------------------------------------



|(2) | An issuer making a notification in respect of a derivative relating the shares of the issuer should complete boxes 1 to 4, 6, 8,13, 14, 16, 23 and 24.
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------------



|(3) | An issuer making a notification in respect of options granted to a director/person discharging managerial responsibilities should complete boxes 1 to 3 and 17 to 24.
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(4) | An issuer making a notification in respect of a financial instrument relating to the shares of the issuer (other than a debenture) should complete boxes 1 to 4, 6, 8, 9, 11, 13, 14,
16, 23 and 24.
|--- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



Please complete
all relevant boxes should in block capital letters.



1. Name of the issuer



CAMBRIDGE
ANTIBODY TECHNOLOGY GROUP PLC



2. State
whether the notification relates to (i) a transaction notified in accordance with DR 3.1.4R(1)(a); or



(ii) DR 3.1.4(R)(1)(b) a disclosure made in accordance with section 324 (as extended by section 328) of the Companies Act 1985; or



(iii) both (i) and (ii)



(ii)



3. Name of person discharging managerial responsibilities/director



PROFESSOR CHRISTOPHER MARSHALL



4. State whether notification relates to a person connected with a person discharging managerial responsibilities/director named in 3 and
identify the connected person



AS IN 3 ABOVE



5. Indicate whether the notification is in respect of a holding of the person
referred to in 3 or 4 above or in respect of a non-beneficial interest



AS IN 3 ABOVE



6. Description of shares (including class), debentures or derivatives or financial instruments relating to shares



ORDINARY 10 PENCE SHARES



7. Name of registered shareholders(s) and, if more than one, the number of shares held by each of them



GREENWOOD NOMINEES LIMITED



8. State the nature of the transaction



QUARTERLY PAYMENT OF PART OF DIRECTORS FEES IN LIEU OF CASH
CONSIDERATION (SEE NOTES AT 23)



9. Number of
shares, debentures or financial instruments relating to shares acquired



231



10. Percentage of issued class acquired
(treasury shares of that class should not be taken into account when calculating percentage)



0.0004%



11. Number of shares, debentures or financial instruments relating to shares disposed.



NIL



12. Percentage of issued class disposed (treasury shares of that class should not be taken into account when calculating percentage)



NIL



13. Price per share or value of transaction



GBP 6.76



14. Date and place of transaction



9 FEBRUARY 2006



LONDON



15. Total holding following notification and total percentage holding following notification (any treasury shares should not be taken into account when calculating
percentage)



1,166



0.0022%



16. Date issuer informed of transaction



9 FEBRUARY 2006



If a person discharging managerial responsibilities has been granted options by the issuer complete the
following boxes



17. Date of grant



18. Period during which or date on which it can be exercised



19. Total amount paid (if any) for grant of the option



20. Description of shares or debentures involved (class and number)



21. Exercise price (if fixed at time of grant) or indication that price is to be fixed at the
time of exercise



22. Total number of shares or debentures over which options
held following notification



23. Any additional information



THE PRACTICE OF ISSUING SHARES IN LIEU OF PART OF THE BASIC DIRECTORS FEE HAS BEEN
ESTABLISHED BY THE COMPANY FOR SOME TIME. IN NOVEMBER 2004 THE BOARD RESOLVED THAT SUCH ISSUE OF SHARES WOULD OCCUR ON A QUARTERLY RATHER THAN AN ANNUAL BASIS. THE SHARE PRICE USED IS THE AVERAGE CLOSING PRICE OF ONE CAT SHARE FOR THE THREE TRADING
DAYS PRECEDING 9 FEBRUARY 2006



24. Name of contact and telephone number for
queries



JUSTIN HOSKINS, 01223 898589



Name and signature of duly authorised officer
of issuer responsible for making notification



JUSTIN HOSKINS, COMPANY SECRETARY



Date of notification



9 FEBRUARY 2006



END



---

NOTIFICATION OF TRANSACTIONS OF DIRECTORS, PERSONS DISCHARGING MANAGERIAL RESPONSIBILITY OR CONNECTED PERSONS



This form is intended for use by an issuer to make a RIS
notification required by DR 3.1.4R(1).



|(1) | An issuer making a notification in respect of a transaction relating to the shares or debentures of the issuer should complete boxes 1 to 16, 23 and 24.
|--- | --------------------------------------------------------------------------------------------------------------------------------------------------------



|(2) | An issuer making a notification in respect of a derivative relating the shares of the issuer should complete boxes 1 to 4, 6, 8,13, 14, 16, 23 and 24.
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------------



|(3) | An issuer making a notification in respect of options granted to a director/person discharging managerial responsibilities should complete boxes 1 to 3 and 17 to 24.
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(4) | An issuer making a notification in respect of a financial instrument relating to the shares of the issuer (other than a debenture) should complete boxes 1 to 4, 6, 8, 9, 11, 13, 14,
16, 23 and 24.
|--- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



Please complete
all relevant boxes should in block capital letters.



1. Name of the issuer



CAMBRIDGE ANTIBODY TECHNOLOGY GROUP PLC



2. State whether the notification relates to (i) a transaction notified in accordance
with DR 3.1.4R(1)(a); or



(ii) DR 3.1.4(R)(1)(b) a disclosure made in
accordance with section 324 (as extended by section 328) of the Companies Act 1985; or



(iii) both (i) and (ii)



(ii)



3. Name of person discharging managerial responsibilities/director



DR PAUL NICHOLSON



4. State whether notification relates to a person connected with a person discharging managerial responsibilities/director named in 3 and identify the connected person



AS IN 3 ABOVE



5. Indicate whether the notification is in respect of a holding of the person referred to in 3 or 4 above or in respect of a non-beneficial
interest



AS IN 3 ABOVE



6. Description of shares (including class), debentures or derivatives or financial
instruments relating to shares



ORDINARY 10 PENCE SHARES



7. Name of registered shareholders(s) and, if more than one, the number of shares held by
each of them



DR PAUL NICHOLSON



8. State the nature of the transaction



QUARTERLY PAYMENT OF PART OF DIRECTORS FEES IN LIEU OF CASH CONSIDERATION (SEE NOTES AT 23)



9. Number of shares, debentures or financial instruments relating to shares
acquired



648



10. Percentage of issued class acquired (treasury shares of that class should not be taken into account when calculating percentage)



0.001%



11. Number of shares, debentures or financial instruments relating to shares disposed.



NIL



12. Percentage of issued class disposed (treasury shares of that class should not be taken into account when calculating percentage)



NIL



13. Price per share or value of transaction



GBP 6.76



14. Date and place of transaction



9 FEBRUARY 2006



LONDON



15. Total holding following notification and total percentage holding following notification
(any treasury shares should not be taken into account when calculating percentage)



11,962



0.023%



16. Date issuer informed of transaction



9 FEBRUARY 2006



If a person discharging managerial responsibilities has been granted options by the issuer complete the
following boxes



17. Date of grant



18. Period during which or date on which it can be exercised



19. Total amount paid (if any) for grant of the option



20. Description of shares or debentures involved (class and number)



21. Exercise price (if fixed at time of grant) or indication that price is to be fixed at the
time of exercise



22. Total number of shares or debentures over which options
held following notification



23. Any additional information



THE PRACTICE OF ISSUING SHARES IN LIEU OF PART OF THE BASIC DIRECTORS FEE HAS BEEN
ESTABLISHED BY THE COMPANY FOR SOME TIME. IN NOVEMBER 2004 THE BOARD RESOLVED THAT SUCH ISSUE OF SHARES WOULD OCCUR ON A QUARTERLY RATHER THAN AN ANNUAL BASIS. THE SHARE PRICE USED IS THE AVERAGE CLOSING PRICE OF ONE CAT SHARE FOR THE THREE TRADING
DAYS PRECEDING 9 FEBRUARY 2006



24. Name of contact and telephone number for
queries



JUSTIN HOSKINS, 01223 898589



Name and signature of duly authorised officer of issuer
responsible for making notification



JUSTIN
HOSKINS, COMPANY SECRETARY



Date of
notification



9 FEBRUARY 2006



END



---

NOTIFICATION OF TRANSACTIONS OF DIRECTORS, PERSONS DISCHARGING MANAGERIAL RESPONSIBILITY OR CONNECTED PERSONS



This form is intended for use by an issuer to make a RIS
notification required by DR 3.1.4R(1).



|(1) | An issuer making a notification in respect of a transaction relating to the shares or debentures of the issuer should complete boxes 1 to 16, 23 and 24.
|--- | --------------------------------------------------------------------------------------------------------------------------------------------------------



|(2) | An issuer making a notification in respect of a derivative relating the shares of the issuer should complete boxes 1 to 4, 6, 8,13, 14, 16, 23 and 24.
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------------



|(3) | An issuer making a notification in respect of options granted to a director/person discharging managerial responsibilities should complete boxes 1 to 3 and 17 to 24.
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(4) | An issuer making a notification in respect of a financial instrument relating to the shares of the issuer (other than a debenture) should complete boxes 1 to 4, 6, 8, 9, 11, 13, 14,
16, 23 and 24.
|--- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



Please complete
all relevant boxes should in block capital letters.



1. Name of the issuer



CAMBRIDGE ANTIBODY TECHNOLOGY GROUP PLC



2. State whether the notification relates to (i) a transaction notified in accordance
with DR 3.1.4R(1)(a); or



(ii) DR 3.1.4(R)(1)(b) a disclosure made in
accordance with section 324 (as extended by section 328) of the Companies Act 1985; or



(iii) both (i) and (ii)



(ii)



3. Name of person discharging managerial responsibilities/director



PROFESSOR JOHN BROWN



4. State whether notification relates to a person connected with a person discharging managerial responsibilities/director named in 3 and identify the connected person



AS IN 3 ABOVE



5. Indicate whether the notification is in respect of a holding of the person referred to in 3 or 4 above or in respect of a non-beneficial
interest



AS IN 3 ABOVE



6. Description of shares (including class), debentures or derivatives or financial
instruments relating to shares



ORDINARY 10 PENCE SHARES



7. Name of registered shareholders(s) and, if more than one, the number of shares held by
each of them



GREENWOOD NOMINEES LIMITED



8. State the nature of the transaction



QUARTERLY PAYMENT OF PART OF DIRECTORS FEES IN LIEU OF CASH CONSIDERATION (SEE NOTES AT 23)



9. Number of shares, debentures or financial instruments relating to shares
acquired



231



10. Percentage of issued class acquired (treasury shares of that class should not be taken into account when calculating percentage)



0.0004%



11. Number of shares, debentures or financial instruments relating to shares disposed.



NIL



12. Percentage of issued class disposed (treasury shares of that class should not be taken into account when calculating percentage)



NIL



13. Price per share or value of transaction



GBP 6.76



14. Date and place of transaction



9 FEBRUARY 2006



LONDON



15. Total holding following notification and total percentage holding following notification
(any treasury shares should not be taken into account when calculating percentage)



278



0.0005%



16. Date issuer informed of transaction



9 FEBRUARY 2006



If a person discharging managerial responsibilities has been granted options by the issuer complete the
following boxes



17. Date of grant



18. Period during which or date on which it can be exercised



19. Total amount paid (if any) for grant of the option



20. Description of shares or debentures involved (class and number)



21. Exercise price (if fixed at time of grant) or indication that price is to be fixed at the
time of exercise



22. Total number of shares or debentures over which options
held following notification



23. Any additional information



THE PRACTICE OF ISSUING SHARES IN LIEU OF PART OF THE BASIC DIRECTORS FEE HAS BEEN
ESTABLISHED BY THE COMPANY FOR SOME TIME. IN NOVEMBER 2004 THE BOARD RESOLVED THAT SUCH ISSUE OF SHARES WOULD OCCUR ON A QUARTERLY RATHER THAN AN ANNUAL BASIS. THE SHARE PRICE USED IS THE AVERAGE CLOSING PRICE OF ONE CAT SHARE FOR THE THREE TRADING
DAYS PRECEDING 9 FEBRUARY 2006



24. Name of contact and telephone number for
queries



JUSTIN HOSKINS, 01223 898589



Name and signature of duly authorised officer of issuer
responsible for making notification



JUSTIN
HOSKINS, COMPANY SECRETARY



Date of
notification



9 FEBRUARY 2006



END