60076 Federal Register / Vol. 70, No. 198 / Friday, October 14, 2005 / Notices 

Construction and Operation of the 

North Link Light Rail Extension, from 

Downtown Seattle and Northgate, 

Updated Information on Refined 

Design Concepts, Funding, Right-ofWay and US Army COE Section 404 

Permits, King County, WA, Comment 

Period Ends: 11/30/2005, Contact: 

John Witmer 206–220–7954 

EIS No. 20050428, Draft EIS, FRC, CA, 

Long Beach Liquefied Natural Gas 

(LNG) Import Project, Construction 

and Operation of a LNG Receiving 

Terminal and Associated Facilities, 

US Army COE 10 and 404 Permits, 

Long Beach, CA, Comment Period 

Ends: 12/08/2005, Contact: Thomas 

Russo 1–866–208–3372 

Amended Notices 

EIS No. 20050328, Draft EIS, FHW, LA, 

US 90 Corridor, Proposed Interstate 

Highway 49 (I49 ) South Improvement 

from Raceland to the Davis Pond 

Diversion Canal, Section of 

Independent Utility 1 (SIU 1), 

Lafourche and St. Charles Parishes, 

LA, Comment Period Ends: 12/31/ 

2005, Contact: William C. Farr 225–

757–7615 Revision of FR Notice 

Published 08/12/2005; Comment 

Period Extended from 9/30/2005 to 

12/31/2005. 

Dated: October 11, 2005. 

Ken Mittelholtz, 

Environmental Protection Specialist, Office 

of Federal Activities. 

[FR Doc. 05–20619 Filed 10–13–05; 8:45 am] 

BILLING CODE 6560–50–U 

ENVIRONMENTAL PROTECTION 

AGENCY 

[E–Docket ID No. ORD–2005–0022; FRL–

7983–9] 

Notice of a Scientific Peer-Review 

Meeting to Review the Draft Document: 

Approaches for the Application of 

Physiologically-Based 

Pharmacokinetic (PBPK) Models and 

Supporting Data in Risk Assessment 

(EPA/600/R–05/043A) 

AGENCY: Environmental Protection 

Agency. 

ACTION: Notice of external peer-review 

panel meeting. 

SUMMARY: The U.S. Environmental 

Protection Agency (EPA) is announcing 

that Versar Inc., an EPA contractor for 

external scientific peer review, will 

convene a panel of experts and organize 

and conduct an independent external 

peer-review workshop to review the 

draft report, ‘‘Approaches for the 

Application of Physiologically-Based 

Pharmacokinetic (PBPK) Models and 

Supporting Data in Risk Assessment’’

(EPA/600/R–05/043A), which was 

prepared by the National Center for 

Environmental Assessment (NCEA) 

within EPA’s Office of Research and 

Development. Versar, Inc. invites the 

public to register to attend this 

workshop as observers. In addition, 

Versar, Inc. invites the public to give 

oral and/or provide written comments at 

the workshop regarding the draft 

document under review. The draft 

document and EPA’s peer-review charge 

are available primarily via the Internet 

on NCEA’s home page under the Recent 

Additions and Publications menus at 

http://www.epa.gov/ncea. In preparing a 

final report, EPA will consider Versar, 

Inc.’s report of the comments and 

recommendations from the external 

peer-review workshop. In addition to 

the workshop announced today, EPA 

previously published a Federal Register 

notice (70 FR 43692) announcing a 

separate process for public comment on 

the draft document on July 28, 2005 and 

a second Federal Register notice (70 FR 

48950) announcing a 45-day extension 

(closing October 14, 2005) of the public 

comment period. 

DATES: Versar, Inc. will hold the peerreview workshop from November 10, 

2005, to November 11, 2005. On the first 

day, the meeting is scheduled to begin 

at 8:30 a.m. and end at 5 p.m., Eastern 

Daylight Time. The public may attend 

the peer-review workshop on November 

10, 2005, as observers. In addition, 

members of the public in attendance at 

the workshop will be allowed to make 

brief (no longer than five minutes) oral 

statements at the commencement of the 

meeting. The second day of the 

workshop is scheduled from 8:30 a.m. to 

12:30 p.m., Eastern Daylight Time. This 

second day will be not be open to the 

public and is meant to provide time for 

the peer-reviewers to begin drafting 

their comments on the draft report. 

ADDRESSES: The external peer-review 

panel meeting will be held at the Hyatt 

Arlington located at 1325 Wilson 

Boulevard, Arlington, VA, 22209. The 

EPA contractor, Versar, Inc., is 

organizing, convening, and conducting 

the peer-review panel meeting. To 

attend the meeting, register by 

November 4, by calling Ms. Amanda 

Jacob of Versar, Inc., 6850 Versar Center, 

Springfield, VA, 22151, at 703–750–

3000 ext. 260, or via e-mail at 

AJacob@versar.com, or by sending a 

facsimile to 703–642–6954. Interested 

parties may also register on-line at: 

http://epa.versar.com/pbpk. Space is 

limited, and reservations will be 

accepted on a first-come, first-served 

basis. At the time of your registration for 

the meeting, please indicate if you 

intend to make an oral statement during 

the public comment period on the first 

day of the meeting. 

FOR FURTHER INFORMATION CONTACT: 

Questions regarding registration and 

logistics for the peer review meeting 

should be directed to Ms. Amanda 

Jacob, Versar, Inc., 6850 Versar Center, 

Springfield, VA, 22151; telephone: 703–

750–3000 ext. 260; facsimile: 703–642–

6954; e-mail: AJacob@versar.com. If you 

have questions about the document, 

please contact Technical Information 

Staff, NCEA, U.S. Environmental 

Protection Agency, Washington, DC 

20460; telephone: 202–564–3261; 

facsimile: 202–565–0050; or e-mail: 

NCEADC.Comment@epa.gov. 

SUPPLEMENTARY INFORMATION: On July 

28, 2005, EPA published a Federal 

Register notice (70 FR 43692) that 

announced a 30-day public comment 

period through August 29, 2005, for 

EPA’s draft report, ‘‘Approaches for the 

Application of Physiologically-Based 

Pharmacokinetic (PBPK) Models and 

Supporting Data in Risk Assessment’’

(EPA/600/R–05/043A). EPA published a 

second notice in the Federal Register on 

August 22, 2005 (70 FR 48950) that 

extended the public comment period for 

45 days from August 29, until October 

14, 2005. On July 28, 2005, the draft 

document was made publicly available 

on NCEA’s Web site for review and 

comment. An electronic version of the 

public docket is available through EPA’s 

electronic public docket and comment 

system, E-Docket. To view comments, 

go to http://www.epa.gov/edocket/, 

select ‘‘search,’’ then key in the docket 

identification number, ORD–2005–0022. 

In the July 28, 2005, notice, EPA also 

announced that a subsequent Federal 

Register notice would announce the 

date and location of a workshop for 

independent external peer review of this 

draft document. Today’s notice provides 

information on that external peer-review 

workshop. 

The purpose of the draft document is 

to describe some approaches for the use 

of physiologically-based 

pharmacokinetic (PBPK) models in risk 

assessment. PBPK models represent an 

important class of dosimetry models 

that are useful for predicting internal 

dose at target organs for risk assessment 

applications. Dose-response 

relationships that appear unclear or 

confusing at the administered dose level 

can become more understandable when 

expressed on the basis of internal dose 

of the chemical. To predict internal dose 

level, PBPK models use 

pharmacokinetic data to construct 

mathematical representations of 

Federal Register / Vol. 70, No. 198 / Friday, October 14, 2005 / Notices 60077 

biological processes associated with the 

absorption, distribution, metabolism, 

and elimination of compounds. With 

the appropriate data, these models can 

be used to extrapolate across species 

and exposure scenarios, and address 

various sources of uncertainty in risk 

assessments. This report addresses the 

following questions: (1) Why do risk 

assessors need PBPK models; (2) How 

can these models be used in risk 

assessments; and (3) What are the 

characteristics of acceptable PBPK 

models for use in risk assessment? 

Dated: October 6, 2005. 

Peter Preuss, 

Director, National Center for Environmental 

Assessment. 

[FR Doc. 05–20600 Filed 10–13–05; 8:45 am] 

BILLING CODE 6560–50–P 

ENVIRONMENTAL PROTECTION 

AGENCY 

[FRL–7983–5] 

Science Advisory Board Staff Office; 

Notification of Advisory Meeting of the 

SAB All-Ages Lead Model (AALM) 

Review Panel 

AGENCY: Environmental Protection 

Agency (EPA). 

ACTION: Notice. 

SUMMARY: The Environmental Protection 

Agency (EPA or Agency) Science 

Advisory Board (SAB) Staff Office 

announces a public meeting of the SAB 

All-Ages Lead Model Review Panel 

(Panel) for the purpose of providing the 

Agency with advice and 

recommendations on the recentlydeveloped All-Ages Lead Model. 

DATES: The meeting will be held 

Thursday, October 27, 2005, from 9 a.m. 

to 5:30 p.m. (eastern time), and Friday, 

October 28, 2005, from 9 a.m. to 2 p.m. 

(eastern time). 

ADDRESSES: The meeting will take place 

at SAB Conference Center, 1025 F 

Street, NW., Suite 3700, Washington, 

DC 20004. 

FOR FURTHER INFORMATION CONTACT: Any 

member of the public who would like to 

submit written or brief oral comments (5 

minutes or less), or wants further 

information concerning this meeting, 

may contact Mr. Fred Butterfield, 

Designated Federal Officer (DFO), EPA 

Science Advisory Board (1400F), U.S. 

Environmental Protection Agency, 1200 

Pennsylvania Avenue, NW., 

Washington, DC 20460; via telephone/ 

voice mail: (202) 343–9994; fax: (202) 

233–0643; or e-mail at: 

butterfield.fred@epa.gov. General 

information concerning the EPA Science 

Advisory Board can be found on the 

EPA Web site at: http://www.epa.gov/ 

sab. 

SUPPLEMENTARY INFORMATION: SAB and 

the AALM Review Panel: The SAB was 

established by 42 U.S.C. 4365 to provide 

independent scientific and technical 

advice, consultation, and 

recommendations to the EPA 

Administrator on the technical basis for 

Agency positions and regulations. The 

SAB is a Federal advisory committee 

chartered under the Federal Advisory 

Committee Act (FACA), as amended, 5 

U.S.C., App. The Panel will provide 

advice through the chartered SAB, and 

will comply with the provisions of 

FACA and all appropriate SAB Staff 

Office procedural policies. 

The SAB Staff Office recently 

established the SAB AALM Review 

Panel to provide the EPA Administrator, 

through the SAB, with advice and 

recommendations on the Agency’s AllAges Lead Model. The Panel will 

comply with the provisions of FACA 

and all appropriate SAB Staff Office 

procedural policies. 

Background: The SAB Staff Office has 

formed this Panel at the request of 

EPA’s Office of Research and 

Development (ORD), National Center for 

Environmental Assessment (NCEA), to 

provide advice and recommendations to 

the Agency on EPA’s recentlydeveloped All-Ages Lead Model 

(AALM). The AALM is designed to 

predict lead concentrations in body 

tissues and organs for a hypothetical 

individual, based on a simulated 

lifetime of lead exposure. Statistical 

methods can be used to extrapolate to a 

population of similarly-exposed 

individuals. The precursor to the AALM 

was the Integrated Exposure Uptake 

Biokinetic (IEUBK) Model for Lead in 

Children. The IEUBK Model underwent 

peer review by the SAB in 1991 and was 

subsequently revised in response to that 

review, leading to release of Version 

0.99d of the IEUBK Model in March 

1994. Since then, the IEUBK Model has 

been widely accepted and used in the 

risk assessment community as a tool for 

implementing the site-specific risk 

assessment process when the issue is 

childhood lead exposure. Based on 

further refinement of the IEUBK Model 

and its expansion for use with 

additional age groups beyond pediatric 

populations 6 years old or younger, the 

AALM has recently been developed to 

cover older childhood and adult lead 

exposure. The anticipated outcome will 

be reduced uncertainty in lead exposure 

assessments for children and adults. 

Any questions concerning either the 

AALM or the IEUBK Model for Lead in 

Children should be directed to Dr. 

Robert Elias, NCEA–RTP, at phone (919) 

541–4167; or e-mail 

elias.robert@epa.gov. 

Availability of Meeting Materials: 

NCEA–RTP has posted the ‘‘All-Ages 

Lead Model (AALM) Version 1.05 

(External Review Draft)’’ and related 

materials (including the Guidance 

Manual for the AALM Version 1.05) on 

the NCEA Web site at http:// 

cfpub.epa.gov/ncea/cfm/ 

recordisplay.cfm?deid=139314. 

Furthermore, the SAB Staff Office will 

post a copy of the final agenda and 

charge to the Panel for this advisory 

meeting on the SAB Web site at 

http://www.epa.gov/sab (under 

‘‘Meeting Agendas’’) and http:// 

www.epa.gov/sab/panels/ 

ad_hoc_aalm_rev_panel.htm in advance 

of the Panel meeting. 

Procedures for Providing Public 

Comment: The SAB Staff Office accepts 

written public comments of any length, 

and will accommodate oral public 

comments whenever possible. The SAB 

Staff Office expects that public will not 

repeat previously-submitted oral or 

written statements. Oral Comments: 

Requests to provide oral comments must 

be in writing (e-mail, fax or mail) and 

received by Mr. Butterfield no later than 

October 20, 2005 to reserve time on the 

October 27, 2005 meeting agenda. 

Opportunities for oral comments will be 

limited to five minutes per speaker. 

Written Comments: Written comments 

should be received in the SAB Staff 

Office by October 21, 2005 so that the 

comments may be made available to the 

members of the members of the SAB 

AALM Review Panel for their 

consideration. Comments should be 

supplied to Mr. Butterfield at the 

contact information provided above, in 

the following formats: one hard copy 

with original signature, and one 

electronic copy via e-mail (acceptable 

file format: Adobe Acrobat PDF, 

WordPerfect, Word, or Rich Text files 

(in IBM–PC/Windows 98/2000/XP 

format)). Those providing written 

comments and who attend the meeting 

in person are also asked to bring 75 

copies of their comments for public 

distribution. 

Meeting: Individuals requiring special 

accommodation at this meeting, 

including wheelchair access to the 

conference room, should contact Mr. 

Butterfield at the phone number or email address noted above no later than 

October 20, 2005 so that appropriate 

arrangements can be made.