EXHIBIT 15.7



NOTIFICATION OF TRANSACTIONS OF DIRECTORS, PERSONS DISCHARGING MANAGERIAL RESPONSIBILITY OR CONNECTED
PERSONS



This form is intended for use by an
issuer to make a RIS notification required by DR 3.1.4R(1).



|(1) | An issuer making a notification in respect of a transaction relating to the shares or debentures of the issuer should complete boxes 1 to 16, 23 and 24.
|--- | --------------------------------------------------------------------------------------------------------------------------------------------------------



|(2) | An issuer making a notification in respect of a derivative relating the shares of the issuer should complete boxes 1 to 4, 6, 8,13, 14, 16, 23 and 24.
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------------



|(3) | An issuer making a notification in respect of options granted to a director/person discharging managerial responsibilities should complete boxes 1 to 3 and 17 to 24.
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(4) | An issuer making a notification in respect of a financial instrument relating to the shares of the issuer (other than a debenture) should complete boxes 1 to 4, 6, 8, 9, 11, 13, 14,
16, 23 and 24.
|--- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



Please complete
all relevant boxes should in block capital letters.



1. Name of the issuer



Cambridge
Antibody Technology Group plc



2. State whether the notification relates to
(i) a transaction notified in accordance with DR 3.1.4R(1)(a); or



(ii)
DR 3.1.4(R)(1)(b) a disclosure made in accordance with section 324 (as extended by section 328) of the Companies Act 1985; or



(iii) both (i) and (ii)



(ii)



---

3. Name of person discharging managerial responsibilities /director



John Aston



4. State whether notification relates to a person connected with a person discharging
managerial responsibilities /director named in 3 and identify the connected person



As in 3. above



5. Indicate whether the notification is in respect of a holding of the person referred to in 3 or 4 above or in respect of a non-beneficial interest



As in 3. above



6. Description of shares (including class), debentures or
derivatives or financial instruments relating to shares



Ordinary 10 Pence Shares



7. Name of registered shareholders(s) and, if more than one, the number of shares held by each of them



Greenwood Nominees Limited



8. State the nature of the transaction



Allotment and issue of new shares in the Company issued at the average mid market quotation as derived from the Daily Official List for the three business days preceding
30 December 2005 such shares having been acquired for the purpose of the Matching Share element of the Executive Incentive Plan.



9. Number of shares, debentures or financial instruments relating to shares acquired



3,816



10. Percentage of issued class acquired (treasury shares of that class should not be taken
into account when calculating percentage)



0.007%



11. Number of shares, debentures or financial instruments
relating to shares disposed



NIL



12. Percentage of issued class disposed (treasury shares of that class should not be taken
into account when calculating percentage)



N/A



13. Price per share or value of transaction



lb.6.976



---

14. Date and place of transaction



30 December 2005



15. Total holding following notification and total percentage holding following notification (any treasury shares should not be taken into
account when calculating percentage)



76,556



16. Date issuer informed of transaction



30 December 2005



If a person discharging managerial responsibilities has been
granted options by the issuer complete the following boxes



17. Date of grant



30 December 2005



18. Period during which or date on which it can
be exercised



30 December 2008 to
29 December 2011



19. Total amount paid (if any) for grant of the option



NIL



20. Description of shares or debentures involved (class and number)



11,448 Ordinary 10 Pence Shares



21. Exercise price (if fixed at time of grant) or indication that price is to be fixed at the
time of exercise



10 pence per share under
option



22. Total number of shares or debentures over which options held
following notification 124,988 of which:



14,161 are options under the Company Share Option Plan



82,507are Restricted Shares under the Executive Incentive Plan



28,329 are Matching Shares under the Executive Incentive Plan



23. Any additional information



Generally speaking all shares under option are subject to performance conditions, details of which can be obtained from the office of the Company Secretary



24. Name of contact and telephone number for queries



---

Justin Hoskins 01223 898589



Name and signature of duly authorised officer of issuer
responsible for making notification



Justin
Hoskins, Company Secretary



Date of
notification



30 December 2005



END



NOTIFICATION OF TRANSACTIONS OF DIRECTORS, PERSONS
DISCHARGING MANAGERIAL RESPONSIBILITY OR CONNECTED PERSONS



This form is intended for use by an issuer to make a RIS notification required by DR 3.1.4R(1).



|(1) | An issuer making a notification in respect of a transaction relating to the shares or debentures of the issuer should complete boxes 1 to 16, 23 and 24.
|--- | --------------------------------------------------------------------------------------------------------------------------------------------------------



|(2) | An issuer making a notification in respect of a derivative relating the shares of the issuer should complete boxes 1 to 4, 6, 8,13, 14, 16, 23 and 24.
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------------



|(3) | An issuer making a notification in respect of options granted to a director/person discharging managerial responsibilities should complete boxes 1 to 3 and 17 to 24.
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(4) | An issuer making a notification in respect of a financial instrument relating to the shares of the issuer (other than a debenture) should complete boxes 1 to 4, 6, 8, 9, 11, 13, 14,
16, 23 and 24.
|--- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



---

Please complete all relevant boxes should in block capital letters.



1. Name of the issuer



Cambridge Antibody Technology Group plc



2. State whether the notification relates to (i) a transaction notified in accordance with DR
3.1.4R(1)(a); or



(ii) DR 3.1.4(R)(1)(b) a disclosure made in accordance with
section 324 (as extended by section 328) of the Companies Act 1985; or



(iii) both (i) and (ii)



(ii)



3. Name
of person discharging managerial responsibilities /director



Peter Chambre



4. State whether notification
relates to a person connected with a person discharging managerial responsibilities /director named in 3 and identify the connected person



As in 3. above



5. Indicate whether the notification is in respect of a holding of the person referred to in 3 or 4 above or in respect of a non-beneficial interest



As in 3. above



6. Description of shares (including class), debentures or
derivatives or financial instruments relating to shares



Ordinary 10 Pence Shares



7. Name of registered shareholders(s) and, if more than one, the number of shares held by each of them



Greenwood Nominees Limited



8. State the nature of the transaction



Allotment and issue of new shares in the Company issued at the average mid market quotation as derived from the Daily Official List for the three business days preceding
30 December 2005 such shares having been acquired for the purpose of the Matching Share element of the Executive Incentive Plan.



9. Number of shares, debentures or financial instruments relating to shares acquired



2,150



10. Percentage of issued class acquired (treasury shares of that class should not be taken
into account when calculating percentage)



0.004%



11. Number of shares, debentures or financial instruments
relating to shares disposed



NIL



---

12. Percentage of issued class disposed (treasury shares of that class should not be taken into account when calculating
percentage)



N/A



13. Price per share or value of transaction



lb.6.976



14. Date and place of transaction



30 December 2005



15. Total holding following notification and total percentage holding following notification (any treasury shares should not be taken into account when calculating percentage)



28,592



16. Date issuer informed of transaction



30 December 2005



If a person discharging managerial responsibilities has been granted options by the issuer complete the following boxes



17. Date of grant



30 December 2005



18. Period during which
or date on which it can be exercised



30 December 2008 to
29 December 2011



19. Total amount paid (if any) for grant of the option



NIL



20. Description of shares or debentures involved (class and number)

6,450 Ordinary 10 Pence Shares



21. Exercise price (if fixed at time of grant) or indication that price is to be fixed at the time of exercise



10 pence per share under option



|22. | Total number of shares or debentures over which options held following notification 387,522 of which:
|--- | -----------------------------------------------------------------------------------------------------



191,969 are options under the Company Share Option Plan



145,021 are Restricted Shares under the Executive Incentive
Plan



50,532 are Matching Shares under the
Executive Incentive Plan



---

23. Any additional information



Generally speaking all shares under option are subject to performance conditions, details of which can be obtained from the office of the Company Secretary



24. Name of contact and telephone number for queries



Justin Hoskins 01223 898589



Name and signature of duly authorised officer of issuer
responsible for making notification



Justin
Hoskins, Company Secretary



Date of
notification



30 December 2005



END



NOTIFICATION OF TRANSACTIONS OF DIRECTORS, PERSONS
DISCHARGING MANAGERIAL RESPONSIBILITY OR CONNECTED PERSONS



This form is intended for use by an issuer to make a RIS notification required by DR 3.1.4R(1).



|(1) | An issuer making a notification in respect of a transaction relating to the shares or debentures of the issuer should complete boxes 1 to 16, 23 and 24.
|--- | --------------------------------------------------------------------------------------------------------------------------------------------------------



|(2) | An issuer making a notification in respect of a derivative relating the shares of the issuer should complete boxes 1 to 4, 6, 8,13, 14, 16, 23 and 24.
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------------



|(3) | An issuer making a notification in respect of options granted to a director/person discharging managerial responsibilities should complete boxes 1 to 3 and 17 to 24.
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(4) | An issuer making a notification in respect of a financial instrument relating to the shares of the issuer (other than a debenture) should complete boxes 1 to 4, 6, 8, 9, 11, 13, 14,
16, 23 and 24.
|--- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



---

Please complete all relevant boxes should in block capital letters.



1. Name of the issuer



Cambridge Antibody Technology Group plc



2. State whether the notification relates to (i) a
transaction notified in accordance with DR 3.1.4R(1)(a); or



(ii) DR
3.1.4(R)(1)(b) a disclosure made in accordance with section 324 (as extended by section 328) of the Companies Act 1985; or



(iii) both (i) and (ii)



(ii)



3. Name of person discharging managerial responsibilities /director



Alexander Duncan



4. State whether notification relates to a person connected with a person discharging managerial responsibilities /director named in 3 and identify the connected
person



As in 3. above



5. Indicate whether the notification is in respect of a holding of the person referred to in
3 or 4 above or in respect of a non-beneficial interest



As in 3. above



6. Description of shares (including class), debentures or derivatives or financial instruments relating to shares



Ordinary 10 Pence Shares



7. Name of registered shareholders(s) and, if more than one, the number of shares held by each of them



Greenwood Nominees Limited



8. State the nature of the transaction



Allotment and issue of new shares in the Company issued at the average mid market quotation
as derived from the Daily Official List for the three business days preceding 30 December 2005 such shares having been acquired for the purpose of the Matching Share element of the Executive Incentive Plan.



9. Number of shares, debentures or financial instruments
relating to shares acquired



716



---

10. Percentage of issued class acquired (treasury shares of that class should not be taken into account when calculating
percentage)



0.001%



11. Number of shares, debentures or financial instruments relating to shares disposed



NIL



12. Percentage of issued class disposed (treasury shares of that class should not be taken
into account when calculating percentage)



N/A



13. Price per share or value of transaction



lb.6.976



14. Date and place of transaction



30 December 2005



15. Total holding following notification and total percentage holding following notification
(any treasury shares should not be taken into account when calculating percentage)



15,155



16. Date issuer informed of transaction



30 December 2005



If a person discharging managerial responsibilities has been granted options by the issuer complete the following boxes



17. Date of grant



30 December 2005



18. Period during which or date on which it can be exercised



30 December 2008 to 29 December 2011



19. Total amount paid (if any) for grant of the option



NIL



20. Description of shares or debentures involved (class and number)



2,148 Ordinary 10 Pence Shares



21. Exercise price (if fixed at time of grant) or indication that price is to be fixed at the
time of exercise



10 pence per share under
option



---

22. Total number of shares or debentures over which options held following notification 66,951 of which:



31,776 are options under the Company Share Option Plan



29,640 are Restricted Shares under the
Executive Incentive Plan



5,535 are Matching
Shares under the Executive Incentive Plan



23. Any additional information



Generally speaking all shares under option are subject to performance
conditions, details of which can be obtained from the office of the Company Secretary



24. Name of contact and telephone number for queries



Justin Hoskins 01223 898589



Name and signature of duly authorised officer of issuer responsible for making notification



Justin Hoskins, Company Secretary



Date of notification



30 December 2005



END



NOTIFICATION OF TRANSACTIONS OF DIRECTORS, PERSONS DISCHARGING MANAGERIAL RESPONSIBILITY OR CONNECTED PERSONS



This form is intended for use by an issuer to make a RIS
notification required by DR 3.1.4R(1).



|(1) | An issuer making a notification in respect of a transaction relating to the shares or debentures of the issuer should complete boxes 1 to 16, 23 and 24.
|--- | --------------------------------------------------------------------------------------------------------------------------------------------------------



|(2) | An issuer making a notification in respect of a derivative relating the shares of the issuer should complete boxes 1 to 4, 6, 8,13, 14, 16, 23 and 24.
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------------



---

|(3) | An issuer making a notification in respect of options granted to a director/person discharging managerial responsibilities should complete boxes 1 to 3 and 17 to 24.
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(4) | An issuer making a notification in respect of a financial instrument relating to the shares of the issuer (other than a debenture) should complete boxes 1 to 4, 6, 8, 9, 11, 13, 14,
16, 23 and 24.
|--- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



Please complete
all relevant boxes should in block capital letters.



1. Name of the issuer



Cambridge Antibody Technology Group plc



2. State whether the notification relates to
(i) a transaction notified in accordance with DR 3.1.4R(1)(a); or



(ii)
DR 3.1.4(R)(1)(b) a disclosure made in accordance with section 324 (as extended by section 328) of the Companies Act 1985; or



(iii) both (i) and (ii)



(ii)



3. Name of person discharging managerial responsibilities /director



Lynn Lester



4. State whether notification relates to a person connected with a person discharging managerial responsibilities /director named in 3 and identify the connected person



As in 3. above



5. Indicate whether the notification is in respect of a holding of the person referred to in
3 or 4 above or in respect of a non-beneficial interest



As in 3. above



6. Description of shares (including class), debentures or derivatives or financial instruments relating to shares



Ordinary 10 Pence Shares



7. Name of registered shareholders(s) and, if more than one, the number of shares held by each of them



Greenwood Nominees Limited



---

8. State the nature of the transaction



Allotment and issue of new shares in the Company issued at the average mid market quotation as derived from the Daily Official List for the
three business days preceding 30 December 2005 such shares having been acquired for the purpose of the Matching Share element of the Executive Incentive Plan.



9. Number of shares, debentures or financial instruments relating to shares acquired



286



10. Percentage of issued class acquired (treasury shares of that class should not be taken
into account when calculating percentage)



0.0005%



11. Number of shares, debentures or financial instruments
relating to shares disposed



NIL



12. Percentage of issued class disposed (treasury shares of that class should not be taken
into account when calculating percentage)



N/A



13. Price per share or value of transaction



lb.6.976



14. Date and place of transaction



30 December 2005



15. Total holding following notification and total percentage holding following notification
(any treasury shares should not be taken into account when calculating percentage)



2,710



16. Date issuer informed of transaction



30 December 2005



If a person discharging managerial responsibilities has been granted options by the issuer complete the following boxes



17. Date of grant



30 December 2005



18. Period during which or date on which it can be exercised



30 December 2008 to 29 December 2011



19. Total amount paid (if any) for grant of the option



NIL



---

20. Description of shares or debentures involved (class and number)



Ordinary 10 Pence Shares



21. Exercise price (if fixed at time of grant) or indication that price is to be fixed at the
time of exercise



10 pence per share under
option



22. Total number of shares or debentures over which options held
following notification 25,764 of which:



12,361 are options under the Company Share Option Plan



10,421 are Restricted Shares under the Executive Incentive Plan



2,982 are Matching Shares under the Executive Incentive Plan



23. Any additional information



Generally speaking all shares under option are subject to performance conditions, details of which can be obtained from the office of the Company Secretary



24. Name of contact and telephone number for queries



Justin Hoskins 01223 898589



Name and signature of duly authorised officer of issuer
responsible for making notification



Justin
Hoskins, Company Secretary



Date of
notification



30 December 2005