EXHIBIT 15.5



NOTIFICATION OF TRANSACTIONS OF DIRECTORS, PERSONS DISCHARGING MANAGERIAL RESPONSIBILITY OR CONNECTED
PERSONS



This form is intended for use by an issuer to make a RIS notification
required by DR 3.1.4R(1).



|(1) | An issuer making a notification in respect of a transaction relating to the shares or debentures of the issuer should complete boxes 1 to 16, 23 and 24.
|--- | --------------------------------------------------------------------------------------------------------------------------------------------------------



|(2) | An issuer making a notification in respect of a derivative relating the shares of the issuer should complete boxes 1 to 4, 6, 8,13, 14, 16, 23 and 24.
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------------



|(3) | An issuer making a notification in respect of options granted to a director/person discharging managerial responsibilities should complete boxes 1 to 3 and 17 to 24.
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(4) | An issuer making a notification in respect of a financial instrument relating to the shares of the issuer (other than a debenture) should complete boxes 1 to 4, 6, 8, 9, 11, 13, 14,
16, 23 and 24.
|--- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



Please complete all relevant boxes should in
block capital letters.



1. Name of the issuer



CAMBRIDGE ANTIBODY TECHNOLOGY GROUP PLC



2. State whether the notification relates to (i) a
transaction notified in accordance with DR 3.1.4R(1)(a); or



(ii) DR
3.1.4(R)(1)(b) a disclosure made in accordance with section 324 (as extended by section 328) of the Companies Act 1985; or



(iii) both (i) and (ii)



(ii)



3. Name of person discharging managerial responsibilities/director



JOHN ASTON



4. State whether notification relates to a person connected with a person discharging managerial responsibilities/director named in 3 and identify the connected person



AS IN 3 ABOVE



---

5. Indicate whether the notification is in respect of a holding of the person referred to in 3 or 4 above or in respect
of a non-beneficial interest



AS IN 3 ABOVE



6. Description of shares (including class),
debentures or derivatives or financial instruments relating to shares



ORDINARY 10 PENCE SHARES



7. Name of registered shareholders(s) and, if more than one, the number of shares held by each of them



COMPUTERSHARE TRUSTEES LIMITED



8. State the nature of the transaction



ALLOCATION OF FREESHARES UNDER INLAND REVENUE APPROVED SHARE INCENTIVE PLAN



9. Number of shares, debentures or financial instruments relating to shares acquired



338



10. Percentage of issued class acquired (treasury shares of that class should not be taken
into account when calculating percentage)



0.0006%



11. Number of shares, debentures or financial instruments
relating to shares disposed



NIL



---

12. Percentage of issued class disposed (treasury shares of that class should not be taken into account when calculating
percentage)



NIL



13. Price per share or value of transaction



lb.6.80



14. Date and place of transaction



1 DECEMBER 2005



LONDON



15. Total holding following
notification and total percentage holding following notification (any treasury shares should not be taken into account when calculating percentage)



60,300



0.114%



16. Date issuer informed of transaction



1 DECEMBER 2005



If a person discharging managerial responsibilities has been granted options by the issuer complete the following boxes



17. Date of grant



2 DECEMBER 2005



18. Period during which or date on which it can be exercised



30 DECEMBER 2008 TO 29 DECEMBER 2011



---

19. Total amount paid (if any) for grant of the option



NIL



20. Description of shares or debentures involved (class and number)



25,742 ORDINARY 10 PENCE SHARES



21. Exercise price (if fixed at time of grant) or indication that price is to be fixed at the time of exercise



10 PENCE PER SHARE SUBJECT TO AWARD



22. Total number of shares or debentures over which options held following notification 143,568 OF WHICH:



44,180 ARE OPTIONS UNDER COMPANY SHARE OPTION PLAN



82,507 ARE RESTRICTED SHARE AWARDS UNDER EXECUTIVE INCENTIVE PLAN



16,881 ARE MATCHING SHARES UNDER EXECUTIVE INCENTIVE PLAN



23. Any additional information



AWARDS GRANTED UNDER THE EXECUTIVE INCENTIVE PLAN ARE SUBJECT TO PERFORMANCE CONDITIONS



24. Name of contact and telephone number for queries



JUSTIN HOSKINS



01223 898589



---

Name and signature of duly authorised officer of issuer responsible for making notification



JUSTIN HOSKINS



COMPANY SECRETARY



Date of notification



2 DECEMBER 2005



END



NOTIFICATION OF TRANSACTIONS OF DIRECTORS, PERSONS
DISCHARGING MANAGERIAL RESPONSIBILITY OR CONNECTED PERSONS



This form is
intended for use by an issuer to make a RIS notification required by DR 3.1.4R(1).



|(1) | An issuer making a notification in respect of a transaction relating to the shares or debentures of the issuer should complete boxes 1 to 16, 23 and 24.
|--- | --------------------------------------------------------------------------------------------------------------------------------------------------------



|(2) | An issuer making a notification in respect of a derivative relating the shares of the issuer should complete boxes 1 to 4, 6, 8,13, 14, 16, 23 and 24.
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------------



|(3) | An issuer making a notification in respect of options granted to a director/person discharging managerial responsibilities should complete boxes 1 to 3 and 17 to 24.
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(4) | An issuer making a notification in respect of a financial instrument relating to the shares of the issuer (other than a debenture) should complete boxes 1 to 4, 6, 8, 9, 11, 13, 14,
16, 23 and 24.
|--- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



Please complete
all relevant boxes should in block capital letters.



1. Name of the issuer



CAMBRIDGE ANTIBODY TECHNOLOGY GROUP PLC



2. State whether the notification relates to (i) a transaction notified in accordance
with DR 3.1.4R(1)(a); or



(ii) DR 3.1.4(R)(1)(b) a disclosure made in
accordance with section 324 (as extended by section 328) of the Companies Act 1985; or



(iii) both (i) and (ii)



(ii)



3. Name of person discharging managerial responsibilities/director



NIGEL BURNS



---

4. State whether notification relates to a person connected with a person discharging managerial
responsibilities/director named in 3 and identify the connected person



AS IN
3 ABOVE



5. Indicate whether the notification is in respect of a holding of the
person referred to in 3 or 4 above or in respect of a non-beneficial interest



AS IN 3 ABOVE



6. Description of shares (including class), debentures
or derivatives or financial instruments relating to shares



ORDINARY 10 PENCE
SHARES



7. Name of registered shareholders(s) and, if more than one, the number
of shares held by each of them



COMPUTERSHARE TRUSTEES LIMITED



8. State the nature of the transaction



ALLOCATION OF FREESHARES UNDER INLAND REVENUE APPROVED SHARE INCENTIVE PLAN



9. Number of shares, debentures or financial instruments relating to shares acquired



294



10. Percentage of issued class acquired (treasury shares of that class should not be taken into account when calculating percentage)



0.0006%



---

11. Number of shares, debentures or financial instruments relating to shares disposed



NIL



12. Percentage of issued class disposed (treasury shares of that class should not be taken into account when calculating percentage)



NIL



13. Price per share or value of transaction



lb.6.80



14. Date and place of transaction



1 DECEMBER 2005



LONDON



15. Total holding following notification and total percentage holding following notification
(any treasury shares should not be taken into account when calculating percentage)



3,554



0.0067%



16. Date issuer informed of transaction



1 DECEMBER 2005



If a person discharging managerial responsibilities has been granted options by the issuer complete the
following boxes



---

17. Date of grant



2 DECEMBER 2005



18. Period during which or date on which it can be exercised



30 DECEMBER 2008 TO 29 DECEMBER 2011



19. Total
amount paid (if any) for grant of the option



NIL



20. Description of shares or debentures involved (class and number)



10,095 ORDINARY 10 PENCE SHARES



21. Exercise price (if fixed at time of grant) or indication that price is to be fixed at the
time of exercise



10 PENCE PER SHARE SUBJECT TO AWARD



22. Total number of shares or debentures over which options held following notification
83,773 OF WHICH:



54,723 ARE OPTIONS UNDER COMPANY SHARE OPTION PLAN



29,050 ARE RESTRICTED SHARE AWARDS UNDER EXECUTIVE INCENTIVE PLAN



23. Any additional information



AWARDS GRANTED UNDER THE EXECUTIVE INCENTIVE PLAN ARE SUBJECT TO PERFORMANCE CONDITIONS



24. Name of contact and telephone number for queries



JUSTIN HOSKINS



---

01223 898589



Name and signature of duly authorised officer of issuer responsible for making notification



JUSTIN HOSKINS



COMPANY SECRETARY



Date of notification



2 DECEMBER 2005



END



NOTIFICATION OF TRANSACTIONS OF DIRECTORS, PERSONS DISCHARGING MANAGERIAL RESPONSIBILITY OR CONNECTED
PERSONS



This form is intended for use by an issuer to make a RIS notification
required by DR 3.1.4R(1).



|(1) | An issuer making a notification in respect of a transaction relating to the shares or debentures of the issuer should complete boxes 1 to 16, 23 and 24.
|--- | --------------------------------------------------------------------------------------------------------------------------------------------------------



|(2) | An issuer making a notification in respect of a derivative relating the shares of the issuer should complete boxes 1 to 4, 6, 8,13, 14, 16, 23 and 24.
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------------



|(3) | An issuer making a notification in respect of options granted to a director/person discharging managerial responsibilities should complete boxes 1 to 3 and 17 to 24.
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(4) | An issuer making a notification in respect of a financial instrument relating to the shares of the issuer (other than a debenture) should complete boxes 1 to 4, 6, 8, 9, 11, 13, 14,
16, 23 and 24.
|--- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



Please complete all relevant boxes should in
block capital letters.



1. Name of the issuer



CAMBRIDGE ANTIBODY TECHNOLOGY GROUP PLC



2. State whether the notification relates to (i) a transaction notified in accordance
with DR 3.1.4R(1)(a); or



(ii) DR 3.1.4(R)(1)(b) a disclosure made in
accordance with section 324 (as extended by section 328) of the Companies Act 1985; or



(iii) both (i) and (ii)



(ii)



---

3. Name of person discharging managerial responsibilities/director



PETER CHAMBRE



4. State whether notification relates to a person connected with a person discharging managerial responsibilities/director named in 3 and
identify the connected person



AS IN 3 ABOVE



5. Indicate whether the notification is in respect of a holding of the person referred to in
3 or 4 above or in respect of a non-beneficial interest



AS IN 3 ABOVE



6. Description of shares (including class), debentures or derivatives or
financial instruments relating to shares



ORDINARY 10 PENCE SHARES



7. Name of registered shareholders(s) and, if more than one, the number of shares held by
each of them



COMPUTERSHARE TRUSTEES LIMITED



8. State the nature of the transaction



ALLOCATION OF FREESHARES UNDER INLAND REVENUE APPROVED SHARE INCENTIVE PLAN



9. Number of shares, debentures or financial instruments relating to shares acquired



352



---

10. Percentage of issued class acquired (treasury shares of that class should not be taken into account when calculating
percentage)



0.0006%



11. Number of shares, debentures or financial instruments relating to shares disposed



NIL



12. Percentage of issued class disposed (treasury shares of that class should not be taken into account when calculating percentage)



NIL



13. Price per share or value of transaction



lb.6.80



14. Date and place of transaction



1 DECEMBER 2005



LONDON



15. Total holding following notification and total percentage holding following notification (any treasury shares should not be taken into
account when calculating percentage)



26,442



0.050%



16. Date issuer informed of transaction



1 DECEMBER 2005



---

If a person discharging managerial responsibilities has been granted options by the issuer complete the following boxes



17. Date of grant



2 DECEMBER 2005



18. Period during which or date on which it can be exercised



30 DECEMBER 2008 TO 29 DECEMBER 2011



19. Total amount paid (if any) for grant of the option



NIL



20. Description of shares or debentures involved (class and number)



52,511 ORDINARY 10 PENCE SHARES



21. Exercise price (if fixed at time
of grant) or indication that price is to be fixed at the time of exercise



10
PENCE PER SHARE SUBJECT TO AWARD



22. Total number of shares or debentures over
which options held following notification 381,072 OF WHICH:



191,969 ARE
OPTIONS UNDER COMPANY SHARE OPTION PLAN



145,021 ARE RESTRICTED SHARE AWARDS
UNDER EXECUTIVE INCENTIVE PLAN



44,082 ARE MATCHING SHARES UNDER EXECUTIVE
INCENTIVE PLAN



23. Any additional information



AWARDS GRANTED UNDER THE EXECUTIVE INCENTIVE PLAN ARE SUBJECT TO PERFORMANCE CONDITIONS



---

24. Name of contact and telephone number for queries



JUSTIN HOSKINS



01223 898589



Name and signature of duly authorised officer of issuer responsible for making notification



JUSTIN HOSKINS



COMPANY SECRETARY



Date of notification



2 DECEMBER 2005



END



NOTIFICATION OF TRANSACTIONS OF DIRECTORS, PERSONS DISCHARGING MANAGERIAL RESPONSIBILITY OR CONNECTED PERSONS



This form is intended for use by an issuer to make a RIS notification required by DR
3.1.4R(1).



|(1) | An issuer making a notification in respect of a transaction relating to the shares or debentures of the issuer should complete boxes 1 to 16, 23 and 24.
|--- | --------------------------------------------------------------------------------------------------------------------------------------------------------



|(2) | An issuer making a notification in respect of a derivative relating the shares of the issuer should complete boxes 1 to 4, 6, 8,13, 14, 16, 23 and 24.
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------------



|(3) | An issuer making a notification in respect of options granted to a director/person discharging managerial responsibilities should complete boxes 1 to 3 and 17 to 24.
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(4) | An issuer making a notification in respect of a financial instrument relating to the shares of the issuer (other than a debenture) should complete boxes 1 to 4, 6, 8, 9, 11, 13, 14,
16, 23 and 24.
|--- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



Please complete all relevant boxes should in
block capital letters.



1. Name of the issuer



CAMBRIDGE ANTIBODY TECHNOLOGY GROUP PLC



---

2. State whether the notification relates to (i) a transaction notified in accordance with DR 3.1.4R(1)(a); or



(ii) DR 3.1.4(R)(1)(b) a disclosure made in accordance with section 324 (as
extended by section 328) of the Companies Act 1985; or



(iii) both
(i) and (ii)



(ii)



3. Name of person discharging managerial responsibilities/director



ALEXANDER DUNCAN



4. State whether notification relates to a person connected with a person discharging managerial responsibilities/director named in 3 and
identify the connected person



AS IN 3 ABOVE



5. Indicate whether the notification is in respect of a holding of the person referred to in
3 or 4 above or in respect of a non-beneficial interest



AS IN 3 ABOVE



6. Description of shares (including class), debentures or derivatives or
financial instruments relating to shares



ORDINARY 10 PENCE SHARES



7. Name of registered shareholders(s) and, if more than one, the number of shares held by
each of them



COMPUTERSHARE TRUSTEES LIMITED



8. State the nature of the transaction



ALLOCATION OF FREESHARES UNDER INLAND REVENUE APPROVED SHARE INCENTIVE PLAN



---

9. Number of shares, debentures or financial instruments relating to shares acquired



323



10. Percentage of issued class acquired (treasury shares of that class should not be taken into account when calculating percentage)



0.0006%



11. Number of shares, debentures or financial instruments relating to shares disposed



NIL



12. Percentage of issued class disposed (treasury shares of that class should not be taken into account when calculating percentage)



NIL



13. Price per share or value of transaction



lb.6.80



14. Date and place of transaction



1 DECEMBER 2005



LONDON



15. Total holding following notification and total percentage holding following notification (any treasury shares should not be taken into
account when calculating percentage)



14,439



0.027%



---

16. Date issuer informed of transaction



1 DECEMBER 2005



If a person discharging managerial responsibilities has been granted options by the issuer complete the following boxes



17. Date of grant



2 DECEMBER 2005



18. Period during which or date on which it can be exercised



30 DECEMBER 2008 TO 29 DECEMBER 2011



19. Total amount paid (if any) for grant of the option



NIL



20. Description of shares or debentures involved (class and number)



11,441 ORDINARY 10 PENCE SHARES



21. Exercise price (if fixed at time
of grant) or indication that price is to be fixed at the time of exercise



10
PENCE PER SHARE SUBJECT TO AWARD



22. Total number of shares or debentures over
which options held following notification 64,803 OF WHICH:



31,776 ARE OPTIONS
UNDER COMPANY SHARE OPTION PLAN



29,640 ARE RESTRICTED SHARE AWARDS UNDER
EXECUTIVE INCENTIVE PLAN



3,387 ARE MATCHING SHARES UNDER EXECUTIVE INCENTIVE
PLAN



---

23. Any additional information



AWARDS GRANTED UNDER THE EXECUTIVE INCENTIVE PLAN ARE SUBJECT TO PERFORMANCE CONDITIONS



24. Name of contact and telephone number for queries



JUSTIN HOSKINS



01223 898589



Name and signature of duly authorised officer of issuer responsible for making notification



JUSTIN HOSKINS



COMPANY SECRETARY



Date of notification



2 DECEMBER 2005



END



NOTIFICATION OF TRANSACTIONS OF DIRECTORS, PERSONS DISCHARGING MANAGERIAL RESPONSIBILITY OR CONNECTED PERSONS



This form is intended for use by an issuer to make a RIS notification required by DR
3.1.4R(1).



|(1) | An issuer making a notification in respect of a transaction relating to the shares or debentures of the issuer should complete boxes 1 to 16, 23 and 24.
|--- | --------------------------------------------------------------------------------------------------------------------------------------------------------



|(2) | An issuer making a notification in respect of a derivative relating the shares of the issuer should complete boxes 1 to 4, 6, 8,13, 14, 16, 23 and 24.
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------------



|(3) | An issuer making a notification in respect of options granted to a director/person discharging managerial responsibilities should complete boxes 1 to 3 and 17 to 24.
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(4) | An issuer making a notification in respect of a financial instrument relating to the shares of the issuer (other than a debenture) should complete boxes 1 to 4, 6, 8, 9, 11, 13, 14,
16, 23 and 24.
|--- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



---

Please complete all relevant boxes should in block capital letters.



1. Name of the issuer



CAMBRIDGE ANTIBODY TECHNOLOGY GROUP PLC



2. State whether the notification relates to (i) a transaction notified in accordance with DR 3.1.4R(1)(a); or



(ii) DR 3.1.4(R)(1)(b) a disclosure made in accordance with section 324 (as extended by
section 328) of the Companies Act 1985; or



(iii) both (i) and (ii)



(ii)



3. Name of person discharging managerial responsibilities/director



JUSTIN HOSKINS



4. State whether notification relates to a person connected with a person discharging managerial responsibilities/director named in 3 and identify the connected person



AS IN 3 ABOVE



5. Indicate whether the notification is in respect of a holding of the person referred to in 3 or 4 above or in respect of a non-beneficial
interest



AS IN 3 ABOVE



6. Description of shares (including class), debentures or derivatives or financial
instruments relating to shares



ORDINARY 10 PENCE SHARES



7. Name of registered shareholders(s) and, if more than one, the number of shares held by
each of them



COMPUTERSHARE TRUSTEES LIMITED



---

8. State the nature of the transaction



ALLOCATION OF FREESHARES UNDER INLAND REVENUE APPROVED SHARE INCENTIVE PLAN



9. Number of shares, debentures or financial instruments relating to shares acquired



294



10. Percentage of issued class acquired (treasury shares of that class should not be taken into account when calculating percentage)



0.0006%



11. Number of shares, debentures or financial instruments relating to shares disposed



NIL



12. Percentage of issued class disposed (treasury shares of that class should not be taken into account when calculating percentage)



NIL



13. Price per share or value of transaction



lb.6.80



14. Date and place of transaction



1 DECEMBER 2005



LONDON



---

15. Total holding following notification and total percentage holding following notification (any treasury shares should
not be taken into account when calculating percentage)



2,460



0.0046%



16. Date issuer informed of transaction



1 DECEMBER 2005



If a person discharging managerial responsibilities has been granted options by the issuer complete the following boxes



17. Date of grant



2 DECEMBER 2005



18. Period during which or
date on which it can be exercised



2 DECEMBER 2008 TO 1 DECEMBER 2015 SUBJECT
TO PERFORMANCE CONDITION



19. Total amount paid (if any) for grant of the
option



NIL



20. Description of shares or debentures involved (class and number)



3,930 ORDINARY 10 PENCE SHARES



21. Exercise price (if fixed at time of grant) or indication that price is to be fixed at the time of exercise



lb.6.84 PENCE PER SHARE SUBJECT TO PERFORMANCE CONDITION



---

22. Total number of shares or debentures over which options held following notification



11,764 OPTIONS UNDER COMPANY SHARE OPTION PLAN



23. Any additional information



NONE



24. Name of contact and telephone number for queries



JUSTIN HOSKINS



01223 898589



Name and signature of duly
authorised officer of issuer responsible for making notification



JUSTIN
HOSKINS



COMPANY SECRETARY



Date of notification



2 DECEMBER 2005



END



NOTIFICATION OF TRANSACTIONS OF DIRECTORS, PERSONS DISCHARGING MANAGERIAL RESPONSIBILITY OR CONNECTED PERSONS



This form is intended for use by an issuer to make a RIS notification required by DR
3.1.4R(1).



|(1) | An issuer making a notification in respect of a transaction relating to the shares or debentures of the issuer should complete boxes 1 to 16, 23 and 24.
|--- | --------------------------------------------------------------------------------------------------------------------------------------------------------



|(2) | An issuer making a notification in respect of a derivative relating the shares of the issuer should complete boxes 1 to 4, 6, 8,13, 14, 16, 23 and 24.
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------------



|(3) | An issuer making a notification in respect of options granted to a director/person discharging managerial responsibilities should complete boxes 1 to 3 and 17 to 24.
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(4) | An issuer making a notification in respect of a financial instrument relating to the shares of the issuer (other than a debenture) should complete boxes 1 to 4, 6, 8, 9, 11, 13, 14,
16, 23 and 24.
|--- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



---

Please complete all relevant boxes should in block capital letters.



1. Name of the issuer



CAMBRIDGE ANTIBODY TECHNOLOGY GROUP PLC



2. State whether the notification relates to (i) a transaction notified in accordance with DR 3.1.4R(1)(a); or



(ii) DR 3.1.4(R)(1)(b) a disclosure made in accordance with section 324 (as extended by
section 328) of the Companies Act 1985; or



(iii) both (i) and (ii)



(ii)



3. Name of person discharging managerial responsibilities/director



LYNN LESTER



4. State whether notification relates to a person connected with a person discharging managerial responsibilities/director named in 3 and identify the connected person



AS IN 3 ABOVE



5. Indicate whether the notification is in respect of a holding of the person referred to in 3 or 4 above or in respect of a non-beneficial
interest



AS IN 3 ABOVE



6. Description of shares (including class), debentures or derivatives or financial
instruments relating to shares



ORDINARY 10 PENCE SHARES



---

7. Name of registered shareholders(s) and, if more than one, the number of shares held by each of them



COMPUTERSHARE TRUSTEES LIMITED



8. State the nature of the transaction



ALLOCATION OF FREESHARES UNDER INLAND REVENUE APPROVED SHARE INCENTIVE PLAN



9. Number of shares, debentures or financial instruments relating to shares acquired



323



10. Percentage of issued class acquired (treasury shares of that class should not be taken into account when calculating percentage)



0.0006%



11. Number of shares, debentures or financial instruments relating to shares disposed



NIL



12. Percentage of issued class disposed (treasury shares of that class should not be taken into account when calculating percentage)



NIL



13. Price per share or value of transaction



lb.6.80



14. Date and place of transaction



1 DECEMBER 2005



LONDON



---

15. Total holding following notification and total percentage holding following notification (any treasury shares should
not be taken into account when calculating percentage)



2,424



0.0046%



16. Date issuer informed of transaction



1 DECEMBER 2005



If a person discharging managerial responsibilities has been granted options by the issuer complete the following boxes



17. Date of grant



2 DECEMBER 2005



18. Period during which or
date on which it can be exercised



30 DECEMBER 2008 TO 29 DECEMBER 2011



19. Total amount paid (if any) for grant of the option



NIL



20. Description of shares or debentures involved (class and number)



7,704 ORDINARY 10 PENCE SHARES



---

21. Exercise price (if fixed at time of grant) or indication that price is to be fixed at the time of exercise



10 PENCE PER SHARE SUBJECT TO AWARD



22. Total number of shares or debentures over which options held following notification
24,906 OF WHICH:



12,361 ARE OPTIONS UNDER COMPANY SHARE OPTION PLAN



10,421 ARE RESTRICTED SHARE AWARDS UNDER EXECUTIVE INCENTIVE PLAN



2,124 ARE MATCHING SHARES UNDER EXECUTIVE INCENTIVE PLAN



23. Any additional information



AWARDS GRANTED UNDER THE EXECUTIVE INCENTIVE PLAN ARE SUBJECT TO PERFORMANCE CONDITIONS



24. Name of contact and telephone number for queries



JUSTIN HOSKINS



01223 898589



Name and signature of duly authorised officer of issuer responsible for making notification



JUSTIN HOSKINS



COMPANY SECRETARY



Date of notification



2 DECEMBER 2005



END



---

NOTIFICATION OF TRANSACTIONS OF DIRECTORS, PERSONS DISCHARGING MANAGERIAL RESPONSIBILITY
OR CONNECTED PERSONS



This form is intended for use by an issuer to make a RIS
notification required by DR 3.1.4R(1).



|(1) | An issuer making a notification in respect of a transaction relating to the shares or debentures of the issuer should complete boxes 1 to 16, 23 and 24.
|--- | --------------------------------------------------------------------------------------------------------------------------------------------------------



|(2) | An issuer making a notification in respect of a derivative relating the shares of the issuer should complete boxes 1 to 4, 6, 8,13, 14, 16, 23 and 24.
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------------



|(3) | An issuer making a notification in respect of options granted to a director/person discharging managerial responsibilities should complete boxes 1 to 3 and 17 to 24.
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(4) | An issuer making a notification in respect of a financial instrument relating to the shares of the issuer (other than a debenture) should complete boxes 1 to 4, 6, 8, 9, 11, 13, 14,
16, 23 and 24.
|--- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



Please complete all relevant boxes should in
block capital letters.



1. Name of the issuer



CAMBRIDGE ANTIBODY TECHNOLOGY GROUP PLC



2. State whether the notification relates to (i) a transaction notified in accordance
with DR 3.1.4R(1)(a); or



(ii) DR 3.1.4(R)(1)(b) a disclosure made in
accordance with section 324 (as extended by section 328) of the Companies Act 1985; or



(iii) both (i) and (ii)



(ii)



3. Name of person discharging managerial responsibilities/director



RICHARD MASON



4. State whether notification relates to a person connected with a person discharging managerial responsibilities/director named in 3 and
identify the connected person



AS IN 3 ABOVE



5. Indicate whether the notification is in respect of a holding of the person referred to in
3 or 4 above or in respect of a non-beneficial interest



AS IN 3 ABOVE



---

6. Description of shares (including class), debentures or derivatives or financial instruments relating to shares



ORDINARY 10 PENCE SHARES



7. Name of registered shareholders(s) and, if more than one, the number of shares held by
each of them



COMPUTERSHARE TRUSTEES LIMITED



8. State the nature of the transaction



ALLOCATION OF FREESHARES UNDER INLAND REVENUE APPROVED SHARE INCENTIVE PLAN



9. Number of shares, debentures or financial instruments relating to shares acquired



308



10. Percentage of issued class acquired (treasury shares of that class should not be taken into account when calculating percentage)



0.0006%



11. Number of shares, debentures or financial instruments relating to shares disposed



NIL



12. Percentage of issued class disposed (treasury shares of that class should not be taken into account when calculating percentage)



NIL



13. Price per share or value of transaction



lb.6.80



---

14. Date and place of transaction



1 DECEMBER 2005



LONDON



15. Total holding following notification and total percentage holding following notification (any treasury shares should not be taken into account when calculating percentage)



3,262



0.0062%



16. Date issuer informed of transaction



1 DECEMBER 2005



If a person discharging managerial responsibilities has been granted options by the issuer
complete the following boxes



17. Date of grant



(1) 2 DECEMBER 2005



(2) 2 DECEMBER 2005



18. Period during which or date on which it can be exercised



(1) 30 DECEMBER 2008 TO 29 DECEMBER 2011



(2) 2 DECEMBER 2008 TO 1 DECEMBER 2015



19. Total amount paid (if any) for grant of the option



NIL



---

20. Description of shares or debentures involved (class and number)



(1) 3,036 ORDINARY 10 PENCE SHARES



(2) 9,137 ORDINARY 10 PENCE SHARES



21. Exercise price (if fixed at time of grant) or indication that price is to be fixed at the
time of exercise



(1) 10 PENCE PER SHARE SUBJECT TO AWARD



(2) lb.6.84 PER SHARE SUBJECT TO PERFORMANCE CONDITION



22. Total number of shares or debentures over which options held following notification
45,138 OF WHICH:



39,958 ARE OPTIONS UNDER COMPANY SHARE OPTION PLAN



5,180 ARE RESTRICTED SHARE AWARDS UNDER EXECUTIVE INCENTIVE PLAN



23. Any additional information



AWARDS GRANTED UNDER THE EXECUTIVE INCENTIVE PLAN ARE SUBJECT TO PERFORMANCE CONDITIONS



24. Name of contact and telephone number for queries



JUSTIN HOSKINS



01223 898589



Name and signature of duly authorised officer of issuer responsible for making notification



JUSTIN HOSKINS



COMPANY SECRETARY



---

Date of notification



2 DECEMBER 2005



END



NOTIFICATION OF TRANSACTIONS OF DIRECTORS, PERSONS DISCHARGING MANAGERIAL RESPONSIBILITY OR CONNECTED PERSONS



This form is intended for use by an issuer to make a RIS notification required by DR 3.1.4R(1).



|(1) | An issuer making a notification in respect of a transaction relating to the shares or debentures of the issuer should complete boxes 1 to 16, 23 and 24.
|--- | --------------------------------------------------------------------------------------------------------------------------------------------------------



|(2) | An issuer making a notification in respect of a derivative relating the shares of the issuer should complete boxes 1 to 4, 6, 8,13, 14, 16, 23 and 24.
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------------



|(3) | An issuer making a notification in respect of options granted to a director/person discharging managerial responsibilities should complete boxes 1 to 3 and 17 to 24.
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(4) | An issuer making a notification in respect of a financial instrument relating to the shares of the issuer (other than a debenture) should complete boxes 1 to 4, 6, 8, 9, 11, 13, 14,
16, 23 and 24.
|--- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



Please complete all relevant boxes should in
block capital letters.



1. Name of the issuer



CAMBRIDGE ANTIBODY TECHNOLOGY GROUP PLC



2. State whether the notification relates to (i) a transaction notified in accordance
with DR 3.1.4R(1)(a); or



(ii) DR 3.1.4(R)(1)(b) a disclosure made in
accordance with section 324 (as extended by section 328) of the Companies Act 1985; or



(iii) both (i) and (ii)



(ii)



3. Name of person discharging managerial responsibilities/director



DIANE MELLETT



4. State whether notification relates to a person connected with a person discharging managerial responsibilities/director named in 3 and
identify the connected person



AS IN 3 ABOVE



---

5. Indicate whether the notification is in respect of a holding of the person referred to in 3 or 4 above or in respect
of a non-beneficial interest



AS IN 3 ABOVE



6. Description of shares (including class), debentures or derivatives or financial
instruments relating to shares



ORDINARY 10 PENCE SHARES



7. Name of registered shareholders(s) and, if more than one, the number of shares held by
each of them



COMPUTERSHARE TRUSTEES LIMITED



8. State the nature of the transaction



ALLOCATION OF FREESHARES UNDER INLAND REVENUE APPROVED SHARE INCENTIVE PLAN



9. Number of shares, debentures or financial instruments relating to shares acquired



308



10. Percentage of issued class acquired (treasury shares of that class should not be taken into account when calculating percentage)



0.0006%



11. Number of shares, debentures or financial instruments relating to shares disposed



NIL



---

12. Percentage of issued class disposed (treasury shares of that class should not be taken into account when calculating
percentage)



NIL



13. Price per share or value of transaction



lb.6.80



14. Date and place of transaction



1 DECEMBER 2005



LONDON



15. Total holding following notification and total percentage holding following notification (any treasury shares should not be taken into
account when calculating percentage)



18,271



0.035%



16. Date issuer informed of transaction



1 DECEMBER 2005



If a person discharging managerial responsibilities has been granted options by the issuer complete the following boxes



17. Date of grant



2 DECEMBER 2005



---

18. Period during which or date on which it can be exercised



30 DECEMBER 2008 TO 29 DECEMBER 2011



19. Total amount paid (if any) for grant of the option



NIL



20. Description of shares or debentures involved (class and number)



19,207 ORDINARY 10 PENCE SHARES



21. Exercise price (if fixed at time of grant) or indication that price is to be fixed at the time of exercise



10 PENCE PER SHARE SUBJECT TO AWARD



22. Total number of shares or debentures over which options held following notification 118,423 OF WHICH:



63,304 ARE OPTIONS UNDER COMPANY SHARE OPTION PLAN



51,108 ARE RESTRICTED SHARE AWARDS UNDER EXECUTIVE INCENTIVE PLAN



4,011 ARE MATCHING SHARES UNDER EXECUTIVE INCENTIVE PLAN



23. Any additional information



AWARDS GRANTED UNDER THE EXECUTIVE INCENTIVE PLAN ARE SUBJECT TO PERFORMANCE CONDITIONS



24. Name of contact and telephone number for queries



JUSTIN HOSKINS



01223 898589



---

Name and signature of duly authorised officer of issuer responsible for making notification



JUSTIN HOSKINS



COMPANY SECRETARY



Date of notification



2 DECEMBER 2005



END



NOTIFICATION OF TRANSACTIONS OF DIRECTORS, PERSONS
DISCHARGING MANAGERIAL RESPONSIBILITY OR CONNECTED PERSONS



This form is
intended for use by an issuer to make a RIS notification required by DR 3.1.4R(1).



|(1) | An issuer making a notification in respect of a transaction relating to the shares or debentures of the issuer should complete boxes 1 to 16, 23 and 24.
|--- | --------------------------------------------------------------------------------------------------------------------------------------------------------



|(2) | An issuer making a notification in respect of a derivative relating the shares of the issuer should complete boxes 1 to 4, 6, 8,13, 14, 16, 23 and 24.
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------------



|(3) | An issuer making a notification in respect of options granted to a director/person discharging managerial responsibilities should complete boxes 1 to 3 and 17 to 24.
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(4) | An issuer making a notification in respect of a financial instrument relating to the shares of the issuer (other than a debenture) should complete boxes 1 to 4, 6, 8, 9, 11, 13, 14,
16, 23 and 24.
|--- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



Please complete all relevant boxes should in
block capital letters.



1. Name of the issuer



CAMBRIDGE ANTIBODY TECHNOLOGY GROUP PLC



2. State whether the notification relates to (i) a transaction notified in accordance
with DR 3.1.4R(1)(a); or



(ii) DR 3.1.4(R)(1)(b) a disclosure made in
accordance with section 324 (as extended by section 328) of the Companies Act 1985; or



(iii) both (i) and (ii)



(ii)



3. Name of person discharging managerial responsibilities/director



PATRICK ROUND



---

4. State whether notification relates to a person connected with a person discharging managerial
responsibilities/director named in 3 and identify the connected person



AS IN
3 ABOVE



5. Indicate whether the notification is in respect of a holding of the
person referred to in 3 or 4 above or in respect of a non-beneficial interest



AS IN 3 ABOVE



6. Description of shares (including class), debentures
or derivatives or financial instruments relating to shares



ORDINARY 10 PENCE
SHARES



7. Name of registered shareholders(s) and, if more than one, the number
of shares held by each of them



COMPUTERSHARE TRUSTEES LIMITED



8. State the nature of the transaction



ALLOCATION OF FREESHARES UNDER INLAND REVENUE APPROVED SHARE INCENTIVE PLAN



9. Number of shares, debentures or financial instruments relating to shares acquired



294



10. Percentage of issued class acquired (treasury shares of that class should not be taken into account when calculating percentage)



0.0006%



---

11. Number of shares, debentures or financial instruments relating to shares disposed



NIL



12. Percentage of issued class disposed (treasury shares of that class should not be taken into account when calculating percentage)



NIL



13. Price per share or value of transaction



lb.6.80



14. Date and place of transaction



1 DECEMBER 2005



LONDON



15. Total holding following notification and total percentage holding following notification (any treasury shares should not be taken into
account when calculating percentage)



294



0.0006%



16. Date issuer informed of transaction



1 DECEMBER 2005



If a person discharging managerial responsibilities has been granted options by the issuer complete the following boxes



---

17. Date of grant



2 DECEMBER 2005



18. Period during which or date on which it can be exercised



30 DECEMBER 2008 TO 29 DECEMBER 2011



19. Total
amount paid (if any) for grant of the option



NIL



20. Description of shares or debentures involved (class and number)



11,557 ORDINARY 10 PENCE SHARES



21. Exercise price (if fixed at time of grant) or indication that price is to be fixed at the
time of exercise



10 PENCE PER SHARE SUBJECT TO AWARD



22. Total number of shares or debentures over which options held following notification
55,466 OF WHICH:



5,725 ARE OPTIONS UNDER COMPANY SHARE OPTION PLAN



49,741 ARE RESTRICTED SHARE AWARDS UNDER EXECUTIVE INCENTIVE PLAN



23. Any additional information



AWARDS GRANTED UNDER THE EXECUTIVE INCENTIVE PLAN ARE SUBJECT TO PERFORMANCE CONDITIONS



24. Name of contact and telephone number for queries



JUSTIN HOSKINS



01223 898589



Name and signature of duly authorised officer of issuer responsible for making notification



JUSTIN HOSKINS



COMPANY SECRETARY



Date of notification



2 DECEMBER 2005



END