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                                                                   Exhibit 10.74


                               GENTA INCORPORATED
                                   TWO OAK WAY
                           BERKELEY HEIGHTS, NJ 07922



                                                     Dated as of  March 27, 2001

Loretta M. Itri, M.D.

Dear Dr. Itri:

         We are pleased that you are interested in becoming an employee of Genta
Incorporated, a Delaware corporation (the "Company"). Accordingly, I would like
to offer you the following terms of engagement (the "Agreement"):

         I.       EMPLOYMENT; DUTIES.

         (a)      As of March 28, 2001, the Company hereby engages and employs
you, and you hereby accept engagement and employment as Executive Vice President
of Clinical Research and Development ("E.V.P. of Clinical R&D") and Chief
Medical Officer of the Company.

         (b)      You shall perform your duties as are customarily associated
with your title. In this job you will report to the Chief Executive Officer of
the Company. You shall perform your duties hereunder at such places as shall be
necessary according to the needs, business or opportunities of the Company, and
you acknowledge and agree that the performance of the duties hereunder may
require significant domestic and international travel by you.

         (c)      Upon commencement of your employment, you shall devote your
best efforts as shall be necessary to the proper discharge of your duties and
responsibilities under this Agreement. You may engage in up to eight hours per
week of other activities unrelated to your employment at the Company, provided
that such other activities are consistent in all respects with your obligations
under sections 5, 6, 7 and 8 of this Agreement. However, notwithstanding
anything else contained in this Agreement, you shall not engage in any other
business activities, whether or not pursued for gain or profit, which will
interfere with your ability to perform any of the functions, powers or duties
required under this Agreement.

         2.       TERM. Your employment hereunder shall be for a term of two
years commencing on March 28 , 2001 (the "Effective Date") and continuing
through March 27, 2003 (the "Term"), unless sooner terminated as hereinafter
provided, and subject to one year extensions as may be agreed to by the parties.



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         3.       COMPENSATION AND BENEFITS.

         (a)      As compensation and benefits for the performance of your
duties on behalf of the Company as E.V.P. of Clinical R&D and Chief Medical
Officer, so long as your employment has not been terminated in accordance with
this Agreement, you shall be compensated and shall receive benefits as follows:

                  (i)      a base salary of a minimum of $265,000 per annum (the
                           "Base Salary"), payable in accordance with the
                           Company's standard payroll practice;

                  (ii)     in consideration of your entry into this Agreement,
                           within thirty (30) days of the Effective Date, you
                           will receive at the discretion of the Company either
                           a cash payment of $50,000, or common stock of the
                           company valued at $50,000.

                  (iii)    a guaranteed minimum bonus of thirty percent (30%) of
                           your Base Salary for each year of the Term, which
                           shall accrue on January 1, 2002 and January 1, 2003,
                           respectively, and be payable in January, 2002 and
                           January, 2003, respectively.

         The Company shall withhold all applicable federal, state and local
taxes, social security and workers' compensation contributions and such other
amounts as may be required by law or agreed upon by the parties with respect to
the compensation payable to you pursuant to this Section 3(a).

         (b)      As approved by the Board of Directors of the Company, you
shall be granted on, on the Effective Date, stock options for the purchase of
240,000 shares of Common Stock of the Company at an exercise price equal to the
NASDAQ closing price of the Common Stock on the Effective Date. All stock
options granted pursuant to this subsection 3(b) shall be governed by the 1998
Stock Incentive Plan and shall be evidenced by a stock option agreement prepared
in accordance with such plan.

         (c)      As approved by the Board of Directors of the Company, you
shall be granted, on the Effective Date, a stock option for the purchase of an
additional 60,000 shares of Common Stock at an exercise price equal to the
NASDAQ closing price of the Common Stock on the Effective Date. The option under
this Subsection 3(c) shall become exercisable in full upon final NDA approval of
the Genasense compound by the U.S. Food and Drug Administration during the Term
and shall be subject to a separate agreement.

         (d)      The Company agrees to reimburse you for reasonable and
necessary travel, business entertainment and other business expenses incurred by
you in connection with the performance of your duties under this Agreement. Such
reimbursements shall be made by the Company on a timely basis upon submission by
you of vouchers in accordance with he Company's standard procedures.


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         (e)      You shall be entitled during the Term to four weeks per annum
vacation time. You may "carry over" up to two weeks of unused vacation time to
the succeeding year, however the maximum vacation accrual allowed at any one
time shall not exceed six weeks.

         (f)      You shall be entitled to participate in any and all medical
insurance, dental insurance, group health, life insurance, disability insurance
and other benefit plans which are made generally available by the Company to its
senior executives. The Company, in its sole discretion, may at any time amend or
terminate any such benefit plans or programs.

         (g)      During the Term only and subject to underwriting approval, you
will be entitled to receive the following life insurance and disability benefits
in addition to those set forth in Subsection 3(f):

                  (i)      The Company will pay the premiums on an ordinary term
                           life insurance policy in a face amount up to three
                           (3) times your Base Salary. In addition, if you
                           purchase an additional ordinary term life insurance
                           policy of up to $2 million, and the premium for such
                           policy exceeds the cost of the Company's current
                           group term life insurance rates, the Company shall
                           reimburse you for the difference between the premium
                           on said policy and the current Company group term
                           rate, up to a maximum of $2,500 per year.

                  (ii)     If your current employer-provided long term
                           disability ("LTD") plan has a higher monthly benefit
                           than the Company's plan, the Company will pay the
                           premium on an individual LTD policy for the
                           difference in coverage between the two LTD plans, up
                           to a maximum of $5,000 per year.

         (h)      You shall be covered by the Company's directors and officers
insurance policy as is generally provided to the Company's directors and
officers.

         (i)      The Company shall pay attorneys' fees incurred by you in
connection with your employment agreement with Ortho Biotech Inc, in an amount
not to exceed $20,000.

         (j)      Subject to Section 11, you must be an employee of the Company
at the time that any compensation is due in order to receive such compensation.

         (k)      In addition you may be eligible for stock option grants
consistent with the stock option guidelines applicable to the Company's other
senior executives.

         4.       REPRESENTATIONS AND WARRANTIES. You hereby represent and
warrant to the Company as follows:

         (a)      Neither the execution and delivery of this Agreement nor the
performance by you of your duties and other obligations hereunder violate or
will violate any statute, law, determination or award, or conflict with or
constitute a default under (whether immediately, upon


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<PAGE>

the giving of notice or lapse of time or both) any prior employment agreement,
contract, or other instrument to which you are a party or by which you are
bound.

         (b)      You have the full right, power and legal capacity to execute
deliver this Agreement and to perform your duties and other obligations
hereunder. This Agreement constitutes your legal, valid and binding obligation,
enforceable against you in accordance with its terms. No approvals or consents
of any persons or entities are required for you to execute and deliver this
Agreement or perform your duties and other obligations hereunder.

         5.       NON-COMPETITION AND NON-SOLICITATION.

         (a)      You understand and recognize that your services to the Company
are special and unique and agree that, upon commencement of your employment as
E.V.P. of Clinical R&D and Chief Medical Officer and, except as provided below,
during the term and for a period of two years following any termination of your
employment, you shall not in any manner directly or indirectly, on behalf of
yourself or any person, firm, partnership, joint venture, corporation or other
business entity (collectively, "Person") solicit, enter into, or engage in any
business using antisense technologyor in which the Company or any of its
subsidiaries has intellectual property rights ("Conflicting Field"), either as
an individual for your own account, or as a partner, joint venturer, executive,
agent, consultant, salesperson, officer, director or shareholder of such Person
("Competitor"); provided, however, that (x) following any termination of your
employment, Conflicting Field shall refer only to the field of using antisense
technology as therapy for cancer as its primary business and, subject to Section
1, nothing in this agreement shall be interpreted so as to prevent you from
accepting employment with any such Person which is or tries to be competitive
with a Conflicting Field so long as you work solely in a division of such Person
which division carries on a bona fide business that is not or does not propose
to be competitive with a Conflicting Field; and (y) nothing herein will preclude
you from holding five percent (5%) or less of the stock of any publicly traded
company, calculated on a fully diluted basis.

         (b)      In further consideration of the payment by the Company to you
of amounts that may hereafter be paid to you pursuant to this Agreement
(including, without limitation, pursuant to Sections 3 and 11 hereof and any
stock option agreement between you and the Company), you agree that upon
commencement of your employment with the Company, and for a period of two years
thereafter or a period of two years subsequent to any termination hereunder, but
subject to section 5(f), you shall not, without the prior written consent of the
Company:

                  (i)      directly or indirectly take any action, or attempt to
                           take any action, which is intended to, or could
                           reasonably be foreseen by you to, induce a material
                           breach of a contract or agreement known to you
                           between the Company and any of its licensors,
                           licenses, clients, customers, vendors, suppliers,
                           agents, consultants, employees (whether or not such
                           consultants, employees (whether or not such employees
                           are "at will" employees) or other person or entity
                           with which the Company has an agreement (each a
                           "Covered Party", collectively, "Covered


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                           Practices); PROVIDED HOWEVER, that such action or
                           attempted action could reasonably be expected to
                           cause a material detriment to the Company, or

                  (ii)     directly or indirectly solicit or attempt to solicit
                           any Covered Party to terminate his, her or its
                           relationship with the Company in material breach of a
                           contract or Agreement with the Company known to you,
                           PROVIDED HOWEVER, that such action or attempted
                           action is likely to cause a material detriment to the
                           Company, or

                  (iii)    subject to subsection 5(e), directly or indirectly
                           solicit or attempt to solicit any of the employees or
                           consultants of the Company to become employees,
                           agents, consultants, representatives or advisors of
                           any other Person; or

                  (iv)     directly or indirectly persuade or seek to persuade
                           any customer of or supplier to the Company to cease
                           to do business or to reduce the amount of business
                           which any customer or supplier has done or
                           contemplates doing with the Company, whether or not
                           the relationship between the Company and such Person
                           was originally established in whole or in part
                           through your efforts, in material breach of a
                           contract or agreement known to you between the
                           Company and such customer or supplier; provided,
                           however, that such action or attempted action could
                           reasonably be expected to cause a material detriment
                           to the Company.

         (c)      Upon commencement of your employment with the Company, and for
a period of two years following any termination of your employment, you agree
that upon the earlier of you (a) negotiating with any Competitor concerning the
possible employment of you by the Competitor, (b) receiving an offer of
employment from a Competitor, or (c) becoming employed by a Competitor, you will
(x) immediately provide notice to the Company of such circumstances and (y)
provide copies of Sections 5, 6, 7, 8 and 9 of this Agreement to the Competitor.
You further agree that the Company may provide notice to a Competitor of your
obligations under this Agreement, including without limitation your obligations
pursuant to Sections 5, 6, 7 and 8 hereof.

         (d)      You understand that the provisions of this Section 5 may limit
your ability to earn a livelihood in a business similar to the business of the
Company but nevertheless agree and hereby acknowledge that the consideration
provided under this Agreement, including any compensation or benefits provided
under Sections 3 and 11 hereof and any stock option agreement is sufficient to
justify the restrictions contained in such provisions. In consideration thereof
and in light of your education, skills and abilities, you agree that you will
not assert in any forum that such provisions prevent you from earning a living
or otherwise are void or unenforceable or should be held void or unenforceable.

         (e)      Nothing in subsection 5(b)(iii) shall be interpreted so as to
prohibit you from accepting offers from persons employed by the Company to be
employed by you or an entity with

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which you become associated, provided that such offers were not solicited,
directly or indirectly, or otherwise encouraged by you.

         6.       OWNERSHIP OF PROPRIETARY INFORMATION.

         (a)      You confirm and agree that all information relating to the
Company's, or an Affiliate's (as defined below) business that has been created
by, discovered by, developed by, learned by, or made known to, the Company, or
any of its subsidiaries, affiliates, licensors, licensees, successors or assigns
(each, an "Affiliate" and, collectively, the "Affiliates") from the commencement
of your employment and at all times thereafter (including, without limitation,
information relating to the Company's business created by, discovered by,
developed by, learned by, reduced to practice by or made known to the Company,
an Affiliate, or you, either alone or jointly with others, during your
employment and information relating to the Company's customers, clients,
suppliers, vendors, consultants, licensors and licensees) or assigned, licensed
or otherwise conveyed to Company or any Affiliate, has been, is and shall be the
sole property of the Company or such Affiliate, as applicable and the Company or
the Affiliate as the case may be, has been, in and should be the sole owner of
all designs, ideas, patents, patent applications, copyrights, copyright
applications and other rights in connection therewith, including but not limited
to the right to make application for statutory protection of any kind in any
country, all of the aforementioned information is hereinafter called
"Proprietary Information" (and shall be deemed Proprietary Information
regardless of whether or not the Proprietary Information is patentable or
copyrightable). By way of illustration, but not limitation, Proprietary
Information includes trade secrets, processes, discoveries, structures, works of
authorship, copyrightable works, trademarks, copyrights, formulas, data, data
sources, know-how, show-how, improvements, information relating to products
(both current and under development), services and technologies, product
concepts, specifications, techniques, information or statistics contained in, or
relating to, promotion or marketing plans and programs, strategies, forecasts,
blueprints, sketches, records, notes, devices, drawings, customer lists,
continuation applications of any kind, trademark applications and information
about the Company's or the Affiliate's employees and/or consultants and
confidential business information of the Company or any Affiliate or any of its
clients, consultants, suppliers, customers, vendors, licensors, licensees and
other third parties (including, without limitation, the compensation, job
responsibility and job performance of such employees and/or consultants).

         (b)      You agree that all Proprietary Information shall be, to the
extent permitted by law, "works made for hire" as that term is defined in the
United States Copyright Act (17 U.S.C. Section 101). You hereby assign to the
Company all rights, title and interest you may have or acquire in all
Proprietary Information; provided, that, subject to subsection 6(d) hereof the
provisions of this Section 6 only apply to information, and Proprietary
Information shall only include such information which:

                  (i)      relates at the time of conception or reduction to
                           practice of the invention to the Company business, or
                           actual or demonstrably anticipated research or
                           development of the Company; or


                                      -6-

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                  (ii)     result from any work performed by you for the
                           Company; or

                  (iii)    was developed on the Company's time or using the
                           Company's equipment, supplies, facilities, or trade
                           secret information,

         (c)      Notwithstanding the foregoing, Proprietary Information shall
not include; (i) information (x) in the public domain not as a result of the
breach of this Agreement or the breach of any other duty owed to the Company or
any other person (y) information lawfully in your possession prior to the date
hereof and not disclosed to you by the Company or an Affiliate and (z)
information disclosed to you without restriction by a third party who had the
right to disclose such information to you;

         (d)      It is understood that no patent, copyright, trademark or other
proprietary right of license is granted to you under this Agreement. Any
disclosure of Proprietary Information and any materials which may accompany any
such disclosure pursuant to your employment under this Agreement will not result
in the grant to you of any rights, express or implied, of any kind.

         7.       CONFIDENTIAL INFORMATION.

         (a)      You agree at all times, including after the Term, to keep in
strictest trust and confidence and not to disclose or make accessible to any
other person without the prior written consent of the Company, the Company's or
any Affiliate's Proprietary Information. You further agree that upon
commencement of your employment and at all times thereafter (i) not to use any
such Proprietary Information for yourself or others; and (ii) not to take any
such material or reproductions embodying Proprietary Information from the
Company's facilities (or any of the Affiliates' facilities) at any time, except
as required during the Term in connection with your duties to the Company.

         (b)      Except with prior written authorization of the Board of
Directors, you agree not to disclose or publish any of the Proprietary
Information, except as required in the performance of your obligations under
this Agreement. You further agree not to disclose or publish information
relating to your former employers, to whom you, the Company or any of its
Affiliates owes an obligation of confidence, at the time of disclosure, to you,
at any time during or after your employment with the Company.

         (c)      Upon written notice by the Company, you shall promptly deliver
to the Company, or, if requested by the Company, promptly destroy all written
Proprietary Information and any other written material containing any
Proprietary Information (whether prepared by the Company, you or a third party),
and will not retain any copies, extracts, summaries or other reproductions in
whole or in part of such written Proprietary Information or other material.

         (d)      You recognize that the Company has received and in the future
will receive confidential or proprietary information from third parties subject
to a duty on the Company's part


                                      -7-
<PAGE>
to maintain the confidentiality of such information and, in some cases, to use
it only for certain limited purposes. You agree that you owe the Company and
such third parties, both during your employment and thereafter, a duty to hold
all such confidential or proprietary information in the strictest confidence and
not to disclose it to any Person (except in a manner that is consistent with the
Company's agreement with the third party) or use it for the benefit of anyone
other than the Company or such third party (consistent with the Company's
agreement with the third party), unless expressly authorized to act otherwise by
the Board of Directors.

         (e)      If during the term and thereafter you are requested or
required (by oral questions, deposition, interrogatories, requests for
information or documents, subpoena, civil investigative demand or any other
process) to disclose all or any part of the Proprietary Information, you will
provide the Company with prompt notice of such request or requirement, so that
the Company, or, as applicable, one or more of its Affiliates, may seek an
appropriate protective order or waive compliance with the provisions of this
Agreement. In such case, the parties will consult with each other as to the
advisability of pursuing any such order or other legal action or available steps
to resist or narrow such request or requirement. If, failing the entry of a
protective order or the receipt of a waiver hereunder, you are, in the opinion
of your counsel, legally compelled to disclose Proprietary Information, you may
disclose that portion of such information which counsel advises you that you are
legally compelled to disclose. In any event, you will use reasonable efforts to
cooperate with the Company in obtaining and will not oppose action by the
Company (or, as applicable, one or more of its Affiliates) to obtain, an
appropriate protective order or other reliable assurance that confidential
treatment will be accorded the disclosure of any Proprietary Information. All
reasonable expenses incurred by you in compliance with this subsection 7(e) will
be reimbursed by the Company.

         8.       DISCLOSURE OF PROPRIETARY INFORMATION.

         (a)      During the Term, and thereafter, you agree that you will
promptly disclose to the Company, or any persons designated by the Company, all
Proprietary Information developed, created, made, conceived, reduced to practice
or learned by the company, any Affiliate or you, either alone or jointly with
others, during the Term and not otherwise known to the Company's officers and
directors.

         (b)      You further agree to assist the Company in every proper way
(but at the Company's expense) to obtain and confirm and from time to time
enforce patents, copyrights or other rights on said Proprietary Information in
any and all countries, and to that end you will execute any documents necessary:

                  (i)      to apply for, obtain and vest in the name of the
                           Company alone (unless the Company otherwise directs)
                           letters patent, copyright or other analogous
                           protection in any country throughout the world and
                           when so obtained or vested to renew and restore the
                           same on behalf of the Company; and

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                  (ii)     to defend any opposition proceedings in respect of
                           such applications and any opposition proceedings or
                           petitions or applications for revocation of such
                           letters patent, copyright or other analogous
                           protection.

         (c)      Your obligation to assist the Company in obtaining and
                  enforcing patents and copyrights for the Proprietary
                  Information in any and all countries shall continue beyond the
                  Term, but the Company agrees to compensate you at a reasonable
                  rate after the expiration of the Term, for time actually spent
                  by you at the Company's request on such assistance.

         9.       ENFORCEMENT. You agree that the remedy at law for any breach
of any covenant contained in Sections 5, 6, 7 or 8 of this Agreement would be
inadequate and cause irreparable damage to the Company. In the event that you
breach or threaten to breach any provisions of Sections 5, 6, 7 or 8, in
addition to any other rights which the Company may have at law or in equity, the
Company shall be entitled, without the posting of a bond or a security, to
injunctive relief to enforce the restrictions contained in this Agreement. In
the event that an actual proceeding is brought in equity to enforce any of the
provisions of Sections 5, 6, 7 or 8, you shall not assert as a defense that
there is an adequate remedy at law, nor shall the Company be prevented from
seeking any other remedies, including without limitation monetary damages, which
may be available to it.

         10.      TERMINATION. Your employment hereunder shall commence as
provided for under Section 2 and shall continue for the period set forth in
Section 2 hereof unless sooner terminated upon the first to occur of the
following events:

         (a)      DEATH. Your death.

         (b)      DISABILITY. You have been unable, for a period of one hundred
eighty (180) consecutive business days, to perform your duties under this
Agreement, as a result of physical or mental illness or injury ("Becoming
Totally Disabled") and the Company shall have communicated to you the fact of
your termination by written notice, which termination shall be effective on the
30th day after receipt of such notice by you (the "Total Disability Effective
Date"), unless you return to full-time performance of your duties before the
Total Disability Effective Date;

         (c)      TERMINATION BY THE COMPANY FOR CAUSE. For purposes of this
Agreement, the term "Cause" shall mean any of the following:

                  (i)      A breach by you of any of the provisions of Sections
                           4, 5, 6, 7 or 8 of this Agreement which results in a
                           material detriment to the Company or any Affiliate
                           thereto;

                  (ii)     Any breach by you of subsection 1(b) or (c) which is
                           not cured by you within 30 days of written notice
                           thereof from the Company; PROVIDED, HOWEVER, your
                           right to


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<PAGE>
                           such 30 day cure period shall be conditioned upon
                           your good faith attempt to cure such breach;

                  (iii)    Any action or omission by you to intentionally harm
                           the Company which is in bad faith and likely to cause
                           a material harm to the Company or any other act or
                           bad faith omission having the effect of materially
                           harming the Company, its business or reputation;

                  (iv)     The perpetration of an intentional and knowing fraud
                           against or adversely affecting the Company or any
                           Covered Party which causes or is likely to cause a
                           material detriment to the Company, or

                  (v)      The conviction of you of any crime classified as a
                           felony.

         (d)      TERMINATION BY THE COMPANY WITHOUT CAUSE. The Company may
terminate your employment hereunder at any time for any reason or no reason by
giving you (30) days prior written notice of the termination.

         (e)      TERMINATION BY YOU. You may terminate your employment
hereunder at any time for any reason or no reason by giving thirty (30) days
prior written notice of termination.

         11.      COMPENSATION FOLLOWING TERMINATION PRIOR TO THE END OF THE
 TERM.

         In the event that your employment hereunder is terminated prior to the
end of the Term, you shall be entitled only to the following compensation and
benefits upon such termination:

         (a)      TERMINATION BY REASON OF DEATH OR BECOMING TOTALLY DISABLED;
TERMINATION BY THE COMPANY FOR CAUSE; TERMINATION BY YOU.

         In the event that your employment is terminated by reason of your death
or your becoming Totally Disabled, or by the Company for Cause or Termination By
You, pursuant to Sections 10(a), 10(b), 10(c) or 10(e), the Company shall pay
the following amounts to you (or your estate, as the case may be):

                  (i)      Any accrued but unpaid Base Salary as of the date of
                           termination for services rendered to the date of
                           termination;

                  (ii)     Any accrued but unpaid expenses required to be
                           reimbursed pursuant to Section 3;

                  (iii)    Any vacation accrued to the date of termination;

                  (iv)     Any accrued but unpaid bonus payments.



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<PAGE>
         The benefits to which you may be entitled upon termination pursuant to
the plans, programs and arrangements referred to in Section 3 hereof shall be
determined and paid in accordance with the terms of such plans, policies and
arrangements.

         (b)      TERMINATION BY THE COMPANY WITHOUT CAUSE. In the event that
your employment is terminated by the Company without Cause pursuant to Section
10(d), the Company shall pay the following amounts to you:

                  (i)      Any accrued but unpaid Base Salary as of the date of
                           termination for services rendered to the date of
                           termination, payable within 30 days;

                  (ii)     Any accrued but unpaid expenses required to be
                           reimbursed pursuant to Section 3, payable within 30
                           days;

                  (iii)    Any vacation accrued to the date of termination,
                           payable within 30 days; and

                  (iv)     As your sole damages and conditioned upon your
                           execution and delivery of a general release in favor
                           of the Company, its employees, Officers, Directors
                           and Affiliates, the lessor of one year of Base Salary
                           and the Base Salary which you would have received for
                           the remainder of the Term.

         The benefits to which you may be entitled upon termination pursuant to
the plans, policies and arrangements referred to in Section 3 hereof shall be
determined and paid in accordance with the terms of such plans, policies and
arrangements.

         (c)      NO OTHER BENEFITS OR COMPENSATION. Except as may be provided
under this Agreement under the terms of any incentive compensation, employee
benefit or fringe benefit plan applicable to you at the time of the termination
of your employment prior to the end of the Term, you shall have no right to
receive any other compensation, or to participate in any other arrangement or
benefit with respect to any future period after such termination.

         12.      NOTICES. Any notice or other communication under this
Agreement shall be in writing and shall be deemed to have been given; when
delivered personally after receipt therefor, one (1) day after being sent by
Federal Express or similar overnight delivery; or three (3) days after being
mailed registered or certified mail, postage prepaid; return receipt requested,
to either party at the address set forth below, or to such other address as
such. party shall give by notice hereunder to the other party.

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<PAGE>

         If to the company:

                           Genta Incorporated
                           Two Oak Way
                           Berkeley Heights, NJ  07922


         With a copy to:

                           Gibbons, Deldeo, Dolan, Griffinger & Vecchione


         If to you:

                           Loretta M. Itri, M.D.



         13.      SEVERABILITY OF PROVISIONS. If any provision of this Agreement
shall be declared by a court of competent jurisdiction to be invalid, illegal or
incapable of being enforced in whole or in part, the remaining conditions and
provisions or portions thereof shall nevertheless remain in full force and
effect and enforceable to the extent they are valid, legal and enforceable and
no provision shall be deemed dependent upon any other covenant or provision
unless so expressed herein. If any provision of this Agreement or any part
thereof is held to be invalid or unenforceable because of the scope or duration
of or the area covered by such provision, the parties hereto agree that the
court making such determination shall reduce the scope, duration and/or the area
of such provision (and substitute appropriate provisions for any such invalid or
unenforceable provisions) in order to make such provision enforceable to the
fullest extent permitted by law and/or shall delete specific words and phrases,
and such modified provision shall then be enforceable and shall be enforced. The
parties hereto recognize that if, in any judicial proceeding, a court shall
refuse to enforce any of the separate covenants contained in this Agreement,
then that invalid or unenforceable covenant contained in this Agreement shall be
deemed eliminated from these provisions to the extent necessary to permit the
remaining separate covenants to be enforced. In the event that any court
determines that the time period or the area, or both are unreasonable and that
any of the covenants is to that extent invalid or unenforceable, the parties
hereto agree that such covenants will remain in full force and effect, first,
for the greatest time period, and second, in the greatest geographical area that
would not render them unenforceable.

         14.      ENTIRE AGREEMENT; MODIFICATION. This Agreement contains the
entire agreement of the parties relating to the subject matter hereof, and the
parties hereto have made no agreements, representations or warranties relating
to the subject matter of this Agreement which are not set

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<PAGE>
forth herein. No modification of this Agreement shall be valid unless made in
writing and signed by the parties hereto.

         15.      BINDING EFFECT. The rights, benefits, duties and obligations
under this Agreement shall inure to, and be binding upon, the Company, its
successors and assigns, and upon you and your legal representatives. This
Agreement constitutes a personal service agreement, and the performance of your
obligations hereunder may not be transferred or assigned by you.

         16.      NON-WAIVER. The failure of either party to insist upon the
strict performance of any terms, conditions and provisions of this Agreement
shall not be construed as a waiver or relinquishment of future compliance
therewith, and said terms, conditions and provisions shall remain in full force
and effect. No waiver of any term or condition of this Agreement on the part of
either party shall be effective for any purpose whatsoever unless such waiver is
in writing and signed by such party.

         17.      GOVERNING LAW. This Agreement shall be governed by, and
construed and interpreted in accordance with, the laws of the State of New
Jersey without regard to principles of conflict of law.

         18.      SURVIVABILITY. The provisions of this Agreement which by their
terms call for performance subsequent to termination of your employment
hereunder, or of this Agreement, shall so survive such termination.

         19.      HEADINGS. The headings of paragraphs are inserted for
convenience and shall not affect any interpretation of this Agreement.


                                      -13-
<PAGE>

         If this letter agreement meets with your approval and you desire to
accept this offer of employment on the terms and conditions set forth herein,
please execute the enclosed copy of this letter and return it to me as soon as
possible.


                                   Sincerely,

                                   GENTA INCORPORATED



                                   By: /s/ Michael S. Weiss
                                       -------------------------------------
                                           Michael S. Weiss
                                           Vice-Chairman


         AGREED AND ACCEPTED
         AS OF THE DATE FIRST SET FORTH ABOVE

         /s/ Loretta M. Itri, M.D.
         -------------------------
         Loretta M. Itri, M.D.








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