EXHIBIT 15.3



SCHEDULE 11



NOTIFICATION OF INTERESTS OF DIRECTORS AND CONNECTED PERSONS



|1) | Name of company
|-- | ---------------



Cambridge Antibody Technology



|2) | Name of director
|-- | ----------------



Peter Chambre



|3) | Please state whether notification indicates that it is in respect of holding of the shareholder named in 2 above or in respect of a non-beneficial interest or in the case of an
individual holder if it is a holding of that persons spouse or children under the age of 18 or in respect of a non-beneficial interest
|-- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



As in 2 above



|4) | Name of the registered holder(s) and, if more than one holder, the number of shares held by each of them (if notified)
|-- | ----------------------------------------------------------------------------------------------------------------------



|Computershare | Trustees Limited
|------------- | ----------------



|5) | Please state whether notification relates to a person(s) connected with the Director named in 2 above and identify the connected person(s)
|-- | ------------------------------------------------------------------------------------------------------------------------------------------



As in 2 above



|6) | Please state the nature of the transaction. For PEP transactions please indicate whether general/single co PEP and if discretionary/non discretionary
|-- | -----------------------------------------------------------------------------------------------------------------------------------------------------



Allocation of Free Shares under Inland Revenue Approved Share Incentive Plan



|7) | Number of shares/amount of stock acquired
|-- | -----------------------------------------



285



|8) | Percentage of issued class
|-- | --------------------------



0.0007%



|9) | Number of shares/amount of stock disposed
|-- | -----------------------------------------



Nil



|10) | Percentage of issued class
|--- | --------------------------



Nil



|11) | Class of security
|--- | -----------------



Ordinary 10 pence shares



|12) | Price per share
|--- | ---------------



£5.95



|13) | Date of transaction
|--- | -------------------



29 November 2004



|14) | Date company informed
|--- | ---------------------



29 November 2004



|15) | Total holding following this notification
|--- | -----------------------------------------



21,907



|16) | Total percentage holding of issued class following this notification
|--- | --------------------------------------------------------------------



0.053%





---

If a director has been granted options by the company please complete thefollowing boxes



|17) | Date of grant
|--- | -------------







|18) | Period during which or date on which exercisable
|--- | ------------------------------------------------







|19) | Total amount paid (if any) for grant of the option
|--- | --------------------------------------------------







|20) | Description of shares or debentures involved: class, number
|--- | -----------------------------------------------------------







|21) | Exercise price (if fixed at time of grant) or indication that price is to be fixed at time of exercise
|--- | ------------------------------------------------------------------------------------------------------







|22) | Total number of shares or debentures over which options held following this notification
|--- | ----------------------------------------------------------------------------------------







|23) | Any additional information
|--- | --------------------------







|24) | Name of contact and telephone number for queries
|--- | ------------------------------------------------



Justin Hoskins, 01223 898589



|25) | Name and signature of authorised company official responsible for making this notification
|--- | ------------------------------------------------------------------------------------------



Diane Mellett, Company Secretary



Date of Notification 29 November 2004



SCHEDULE 11



NOTIFICATION OF INTERESTS OF DIRECTORS AND CONNECTED PERSONS



|1) | Name of company
|-- | ---------------



Cambridge Antibody Technology



|2) | Name of director
|-- | ----------------



John Aston



|3) | Please state whether notification indicates that it is in respect of holding of the shareholder named in 2 above or in respect of a non-beneficial interest or in the case of an
individual holder if it is a holding of that persons spouse or children under the age of 18 or in respect of a non-beneficial interest
|-- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



As in 2 above



|4) | Name of the registered holder(s) and, if more than one holder, the number of shares held by each of them (if notified)
|-- | ----------------------------------------------------------------------------------------------------------------------



Computershare Trustees Limited



|5) | Please state whether notification relates to a person(s) connected with the Director named in 2 above and identify the connected person(s)
|-- | ------------------------------------------------------------------------------------------------------------------------------------------



As in 2 above



|6) | Please state the nature of the transaction. For PEP transactions please indicate whether general/single co PEP and if discretionary/non discretionary
|-- | -----------------------------------------------------------------------------------------------------------------------------------------------------



Allocation of Free Shares under Inland Revenue Approved Share Incentive Plan



|7) | Number of shares/amount of stock acquired
|-- | -----------------------------------------



285



|8) | Percentage of issued class
|-- | --------------------------



0.0007%





---

|9) | Number of shares/amount of stock disposed
|-- | -----------------------------------------



Nil



|10) | Percentage of issued class
|--- | --------------------------



Nil



|11) | Class of security
|--- | -----------------



Ordinary 10 pence shares



|12) | Price per share
|--- | ---------------



£5.95



|13) | Date of transaction
|--- | -------------------



29 November 2004



|14) | Date company informed
|--- | ---------------------



29 November 2004



|15) | Total holding following this notification
|--- | -----------------------------------------



39,000



|16) | Total percentage holding of issued class following this notification
|--- | --------------------------------------------------------------------



0.094%



If a director has been granted options by the company please complete the following boxes



|17) | Date of grant
|--- | -------------







|18) | Period during which or date on which exercisable
|--- | ------------------------------------------------







|19) | Total amount paid (if any) for grant of the option
|--- | --------------------------------------------------







|20) | Description of shares or debentures involved: class, number
|--- | -----------------------------------------------------------







|21) | Exercise price (if fixed at time of grant) or indication that price is to be fixed at time of exercise
|--- | ------------------------------------------------------------------------------------------------------







|22) | Total number of shares or debentures over which options held following this notification
|--- | ----------------------------------------------------------------------------------------







|23) | Any additional information
|--- | --------------------------







|24) | Name of contact and telephone number for queries
|--- | ------------------------------------------------



Justin Hoskins, 01223 898589



|25) | Name and signature of authorised company official responsible for making this notification
|--- | ------------------------------------------------------------------------------------------



Diane Mellett, Company Secretary



Date of Notification 29 November 2004





---

SCHEDULE 11



NOTIFICATION OF INTERESTS OF DIRECTORS AND CONNECTED PERSONS



|1) | Name of company
|-- | ---------------



Cambridge Antibody Technology



|2) | Name of director
|-- | ----------------



David Glover



|3) | Please state whether notification indicates that it is in respect of holding of the shareholder named in 2 above or in respect of a non-beneficial interest or in the case of an
individual holder if it is a holding of that persons spouse or children under the age of 18 or in respect of a non-beneficial interest
|-- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



As in 2 above



|4) | Name of the registered holder(s) and, if more than one holder, the number of shares held by each of them (if notified)
|-- | ----------------------------------------------------------------------------------------------------------------------



Computershare Trustees Limited



|5) | Please state whether notification relates to a person(s) connected with the Director named in 2 above and identify the connected person(s)
|-- | ------------------------------------------------------------------------------------------------------------------------------------------



As in 2 above



|6) | Please state the nature of the transaction. For PEP transactions please indicate whether general/single co PEP and if discretionary/non discretionary
|-- | -----------------------------------------------------------------------------------------------------------------------------------------------------



Allocation of Free Shares under Inland Revenue Approved Share Incentive Plan



|7) | Number of shares/amount of stock acquired
|-- | -----------------------------------------



218



|8) | Percentage of issued class
|-- | --------------------------



0.0005%



|9) | Number of shares/amount of stock disposed
|-- | -----------------------------------------



Nil



|10) | Percentage of issued class
|--- | --------------------------



Nil



|11) | Class of security
|--- | -----------------



Ordinary 10 pence shares



|12) | Price per share
|--- | ---------------



£5 .95



|13) | Date of transaction
|--- | -------------------



29 November 2004



|14) | Date company informed
|--- | ---------------------



29 November 2004



|15) | Total holding following this notification
|--- | -----------------------------------------



13,730



|16) | Total percentage holding of issued class following this notification
|--- | --------------------------------------------------------------------



0.033%



If a director has been granted options by the company please complete the following boxes



|17) | Date of grant
|--- | -------------







|18) | Period during which or date on which exercisable
|--- | ------------------------------------------------







|19) | Total amount paid (if any) for grant of the option
|--- | --------------------------------------------------





---

|20) | Description of shares or debentures involved: class, number
|--- | -----------------------------------------------------------







|21) | Exercise price (if fixed at time of grant) or indication that price is to be fixed at time of exercise
|--- | ------------------------------------------------------------------------------------------------------







|22) | Total number of shares or debentures over which options held following this notification
|--- | ----------------------------------------------------------------------------------------







|23) | Any additional information
|--- | --------------------------







|24) | Name of contact and telephone number for queries
|--- | ------------------------------------------------



Justin Hoskins, 01223 898589



|25) | Name and signature of authorised company official responsible for making this notification
|--- | ------------------------------------------------------------------------------------------



Diane Mellett, Company Secretary



Date of Notification 29 November 2004



END