EX-4.2



 Exhibit 4.2 
 FIFTEENTH SUPPLEMENTAL INDENTURE 
 FIFTEENTH SUPPLEMENTAL INDENTURE (this
“Supplemental Indenture”), dated as of April 3, 2013, among IONIAN TECHNOLOGIES INC., STANDING STONE, INC., AVEE LABORATORIES INC., ALERE INFORMATICS, INC., ALERE WELLOGIC, LLC, ESCREEN, INC., ATS LABORATORIES, INC., SCREEN
TOX, INC., GLOBAL ANALYTICAL DEVELOPMENT LLC, AND PEMBROOKE OCCUPATIONAL HEALTH, INC. (collectively, the “New Guarantors”), which are Subsidiaries of Alere Inc. (or its successor) (the “Issuer”), ALERE INC., a
Delaware corporation, on behalf of itself and the Guarantors (the “Existing Guarantors”) under the Indenture referred to below, and U.S. BANK NATIONAL ASSOCIATION, as Trustee under the Indenture referred to below (the
“Trustee”). 
 WITNESSETH: 
 WHEREAS the Issuer has heretofore executed and delivered an Indenture dated as of May 12, 2009, as amended, supplemented and modified by a Ninth Supplemental Indenture dated as of September 21,
2010, an Eleventh Supplemental Indenture dated as of June 16, 2011, and a Thirteenth Supplemental Indenture dated as of June 16, 2011 (as so amended, supplemented or modified, and as further amended, supplemented or modified to date, the
“Indenture”), by and among the Issuer, the Existing Guarantors and the Trustee, providing for the issuance of 8.625% Senior Subordinated Notes due 2018 (the “Notes”); 

WHEREAS Section 4.13 of the Indenture provides that under certain circumstances the Issuer is required to cause each of the New
Guarantors to execute and deliver to the Trustee a supplemental indenture pursuant to which each of the New Guarantors shall unconditionally and irrevocably guarantee all of the Issuer’s obligations under the Notes pursuant to a guarantee on
the terms and conditions set forth herein; and 
 WHEREAS pursuant to Section 9.01 of the Indenture, the Trustee, the
Issuer and the Existing Guarantors are authorized to execute and deliver this Supplemental Indenture; 
 NOW THEREFORE, in
consideration of the foregoing and for other good and valuable consideration, the receipt of which is hereby acknowledged, the New Guarantors, the Trustee and, on behalf of itself and the Existing Guarantors, the Issuer mutually covenant and agree
for the equal and ratable benefit of the Holders as follows: 
 SECTION 1. Definitions. For all purposes of this
Supplemental Indenture, except as otherwise herein expressly provided or unless the context otherwise requires: (i) the terms and expressions used herein shall have the same meanings as corresponding terms and expressions used in the Indenture;
and (ii) the words “herein,” “hereof” and “hereby” and other words of similar import used in this Supplemental Indenture refer to this Supplemental Indenture as a whole and not to any particular section hereof.

 SECTION 2. Agreement to Guarantee. Each of the New Guarantors hereby unconditionally and irrevocably agrees, jointly
and severally with all other Guarantors, to guarantee the Issuer’s obligations under the Notes and the Indenture on the terms and subject to the conditions set forth in Article Eleven of the Indenture and to be bound by all other applicable
provisions of the Indenture. 







 SECTION 3. Ratification of Indenture; Supplemental Indenture Part of Indenture.
Except as expressly amended hereby, the Indenture is in all respects ratified and confirmed and all the terms, conditions and provisions thereof shall remain in full force and effect. This Supplemental Indenture shall form a part of the Indenture
for all purposes, and every Holder of Notes heretofore or hereafter authenticated and delivered shall be bound hereby. 

SECTION 4. Governing Law. This Supplemental Indenture shall be governed by, and construed in accordance with, the laws of the
State of New York, but without giving effect to applicable principles of conflicts of laws to the extent that the application of the laws of another jurisdiction would be required thereby. 

SECTION 5. Trustee Makes No Representation. The Trustee makes no representation as to the validity or sufficiency of this
Supplemental Indenture or for the recitals contained herein. 
 SECTION 6. Counterparts. The parties may sign any number
of copies of this Supplemental Indenture. Each signed copy shall be an original, but all of them together represent the same agreement. 
 SECTION 7. Effect of Headings. The Section headings herein are for convenience only and shall not effect the construction thereof. 

  
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 IN WITNESS WHEREOF, the parties hereto have caused this Supplemental Indenture to be duly
executed as of the date first above written. 
  

			
	 NEW GUARANTORS:
  

IONIAN TECHNOLOGIES INC.
 STANDING STONE,
INC.
 AVEE LABORATORIES INC.
 ALERE
INFORMATICS, INC.
 ALERE WELLOGIC, LLC

ESCREEN, INC.
 ATS LABORATORIES, INC.

SCREEN TOX, INC.
 PEMBROOKE OCCUPATIONAL HEALTH,
INC., as New Guarantors

		
	By:	 	/s/ Ellen V. Chiniara
		 	 Name: Ellen V. Chiniara

Title: Secretary

	
	GLOBAL ANALYTICAL DEVELOPMENT LLC, as a New Guarantor


  

			
	By: ATS LABORATORIES, INC., ITS MANAGING MEMBER
		
	By:	 	/s/ Ellen V. Chiniara
	Name: Ellen V. Chiniara
	Title: Secretary



  
 Signature
Page to Fifteenth Supplemental Indenture 








 
			
	 ISSUER:
  

ALERE INC.

		
	By:	 	/s/ David A. Teitel
		 	 Name: David A. Teitel

Title: Chief Financial Officer and Treasurer




  
 Signature
Page to Fifteenth Supplemental Indenture 








 
			
	 EXISTING GUARANTORS:
  

ALERE HEALTH, LLC

ALERE HEALTHCARE OF ILLINOIS, INC.

ALERE HEALTH IMPROVEMENT COMPANY

ALERE HOME MONITORING, INC.

ALERE INTERNATIONAL HOLDING CORP.

ALERE NEWCO, INC.

ALERE NEWCO II, INC.

ALERE NORTH AMERICA, INC.

ALERE OF NEW YORK, INC.

ALERE SAN DIEGO, INC.

ALERE SCARBOROUGH, INC.

ALERE US HOLDINGS, LLC

ALERE WELLBEING
 ALERE WELLOLOGY, INC.
 ALERE WOMEN’S AND
CHILDREN’S HEALTH, LLC
 AMEDITECH INC.

BINAX, INC.
 BIOSITE INCORPORATED
 FIRST CHECK DIAGNOSTICS
CORP.
 FIRST CHECK ECOM, INC.

		
	By:	 	/s/ David A. Teitel
		 	 Name: David A. Teitel
 Title (respectively): Vice President and Treasurer; Vice President, Finance and Treasurer; Vice President and Treasurer; Vice President, Finance; President; President; President; Vice President, Finance;
Vice President, Finance; Vice President, Finance; Vice President, Finance; President; Vice President, Finance and Treasurer; Vice President and Treasurer; Vice President, Finance; Chief Financial Officer; Vice President, Finance; Vice President,
Finance; Vice President, Finance; Vice President, Finance




  
 Signature
Page to Fifteenth Supplemental Indenture 









			
	 EXISTING GUARANTORS (continued):
  

INNOVACON, INC.
 INSTANT TECHNOLOGIES, INC.
 INVERNESS MEDICAL,
LLC
 IVC INDUSTRIES, INC.

QUALITY ASSURED SERVICES, INC.

REDWOOD TOXICOLOGY LABORATORY, INC.

RMD NETWORKS, INC.

RTL HOLDINGS, INC.

SELFCARE TECHNOLOGY, INC.

ZYCARE, INC.

		
	By:	 	/s/ David A. Teitel
		 	 Name: David A. Teitel
 Title (respectively): Vice President, Finance; Vice President, Finance; Vice President, Finance; President; Vice President, Finance; Vice President, Finance; Vice President, Finance and Treasurer; Vice
President, Finance; Vice President, Finance; Chief Financial Officer and Treasurer




  
 Signature
Page to Fifteenth Supplemental Indenture 








 
			
	 EXISTING GUARANTORS (continued):
  

ALERE TOXICOLOY SERVICES, INC.

LABORATORY SPECIALISTS OF AMERICA, INC.

		
	By:	 	/s/ Jay McNamara
		 	 Name: Jay McNamara
 Title:
Assistant Secretary




  
 Signature
Page to Fifteenth Supplemental Indenture 








 
			
	 U.S. BANK NATIONAL ASSOCATION,

as Trustee

		
	By:	 	/s/ Thomas E. Tabor
		 	 Name: Thomas E. Tabor

Title: Vice President




  
 Signature
Page to Fifteenth Supplemental Indenture