Exhibit 15.2



NOTIFICATION OF TRANSACTIONS OF DIRECTORS, PERSONS DISCHARGING MANAGERIAL RESPONSIBILITY OR CONNECTED PERSONS



This form is intended for use by an issuer to make a RIS notification required
by DR3.1.4R(1).



|(1) | An issuer making a notification in respect of a transaction relating to the shares or debentures of the issuer should complete boxes 1 to 16, 23 and 24.
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|(2) | An issuer making a notification in respect of a derivative relating the shares of the issuer should complete boxes 1 to 4, 6, 8,13, 14, 16, 23 and 24.
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|(3) | An issuer making a notification in respect of options granted to a director/person discharging managerial responsibilities should complete boxes 1 to 3 and 17 to 24.
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|(4) | An issuer making a notification in respect of a financial instrumentrelating to the shares of the issuer (other than a debenture) should complete boxes
1 to 4, 6, 8, 9, 11, 13, 14, 16, 23 and 24.
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



Please complete all
relevant boxes should in block capital letters.



1. Name of the issuer



CAMBRIDGE ANTIBODY TECHNOLOGY GROUP PLC



2. State whether the notification relates to (i) a transaction notified in accordance
with DR3.1.4R(1)(a); or



(ii) DR 3.1.4(R)(1)(b) a disclosure
made in accordance with section 324 (as extended by section 328) of the Companies Act 1985; or



(iii) both (i) and (ii)



(ii)



3. Name of person discharging managerial responsibilities/director



DIANE MELLETT



4. State whether notification relates to a person
connected with a person discharging managerial responsibilities/director named in 3 and identify the connected person



AS IN 3 ABOVE



5. Indicate whether the notification is in respect of a holding of the personreferred to in 3 or 4 above or in respect of a non-beneficial interest



AS IN 3 ABOVE



6. Description of shares (including class), debentures or derivatives or financial instruments relating to shares



---

ORDINARY 10 PENCE SHARES



7. Name of registered shareholders(s) and, if more than one, the number of shares held by each of them



GREENWOOD NOMINEES LIMITED



8. State the nature of the transaction



PURCHASE OF SHARES FOLLOWING EXERCISE OF OPTION



9. Number of shares, debentures or financial instruments relating to sharesacquired



7597



10. Percentage of issued class acquired (treasury shares of that class should not be taken into account when calculating percentage)



0.014%



11. Number of shares, debentures or financial instruments relating to sharesdisposed



NIL



12. Percentage of issued class disposed (treasury shares of that class should not be taken into account when
calculating percentage)



NIL



13. Price per share or value of transaction



£2.42



14. Date and place of transaction



25 NOVEMBER 2005



LONDON



15. Total holding following
notification and total percentage holding following notification (any treasury shares should not be taken into account when calculating percentage)



22,659



0.043%



16. Date issuer informed of transaction



25 NOVEMBER 2005



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If a person discharging managerial responsibilities has been granted options by the issuer complete the following
boxes



17. Date of grant



_________________________________________



18. Period during which or date on which it can be exercised



_________________________________________



19. Total amount paid (if any) for grant of the option



_________________________________________



20. Description of shares or debentures involved (class and number)



_________________________________________



_________________________________________



21. Exercise price (if fixed at time of grant) or indication that price is to be fixed at the
time of exercise



_________________________________________



22. Total number of shares or debentures over which options held following
notification



_________________________________________



23. Any additional information



THE OPTION WHICH WAS EXERCISED WAS DUE TO IRREVOCABLY LAPSE ON 27 NOVEMBER 2005 IF IT HAD NOT BEEN EXERCISED PRIOR TO THAT DATE.



24. Name of contact and telephone number for queries



JUSTIN HOSKINS



01223 898 589



Name and signature of duly authorised officer of issuer responsible for making notification



JUSTIN HOSKINS, COMPANY SECRETARY



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Date of notification



25 NOVEMBER 2005

END