**Exhibit 31.1**
 
 **Certification
by the Chief Executive Officer Pursuant to**
 **Section 302
of the Sarbanes-Oxley Act of 2002**
 
 I, Arnold
S. Lippa, certify that:
 
 1. I have
reviewed this annual report on Form 10-K/A (as amended) of DOV
Pharmaceutical, Inc.;
 
 2. Based
on my knowledge, this report does not contain any untrue statement of a material
fact or omit to state a material fact necessary to make the statements made, in
light of the circumstances under which such statements were made, not misleading
with respect to the period covered by this report;
 
 3. Based
on my knowledge, the financial statements, and other financial information
included in this report, fairly present in all material respects the financial
condition, results of operations and cash flows of registrant as of, and for,
the periods presented in this report;
 
 4.
Registrant’s other certifying officer and I are responsible for establishing and
maintaining disclosure controls and procedures (as defined in Exchange Act
Rules 13a-15(e) and 15d-15(e)) and internal control over financial
reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for
registrant and have:
 
 a)  Designed
such disclosure controls and procedures, or caused such disclosure controls and
procedures to be designed under our supervision, to ensure that material
information relating to registrant, including its consolidated subsidiaries, is
made known to us by others within those entities, particularly during the period
in which this report is being prepared;
 
 b)  Designed
such internal control over financial reporting, or caused such internal control
over financial reporting to be designed under our supervision, to provide
reasonable assurance regarding the reliability of financial reporting and the
preparation of financial statements for external purposes in accordance with
generally accepted accounting principles;
 
 c)  Evaluated
the effectiveness of registrant’s disclosure controls and procedures and
presented in this report our conclusions about the effectiveness of the
disclosure controls and procedures, as of the end of the period covered by this
report based on such evaluation; and
 
 d)  Disclosed
in this report any change in registrant’s internal control over financial
reporting that occurred during registrant’s most recent fiscal quarter that has
materially affected, or is reasonably likely to materially affect, registrant’s
internal control over financial reporting; and
 
 5.
Registrant’s other certifying officer and I have disclosed, based on our most
recent evaluation of internal control over financial reporting, to registrant’s
auditors and the audit committee of registrant’s board of directors (or persons
performing the equivalent functions):
 
 a)  All
significant deficiencies and material weaknesses in the design or operation of
internal control over financial reporting that are reasonably likely to
adversely affect registrant’s ability to record, process, summarize and report
financial information; and
 
 b)  Any
fraud, whether or not material, that involves management or other employees who
have a significant role in registrant’s internal control over financial
reporting.
 
 Date:
March 18, 2005
 
 /s/
Arnold S. Lippa
 Arnold S. Lippa
 Co-Chairman
of the Board, Chief Executive Officer and President