<PAGE>   1
===============================================================================

                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                    FORM 10-K

(Mark One)
[X]     Annual Report Pursuant to Section 13 or 15(d) of the Securities
        Exchange Act of 1934 For the fiscal year ended December 31, 2000
                                       OR
[ ]     Transition Report Pursuant to Section 13 or 15(d) of the Securities Act
        of 1934 For the transition period from _______ to _______

                           COMMISSION FILE NO. 0-23948

                         BOYD BROS. TRANSPORTATION INC.
             (EXACT NAME OF REGISTRANT AS SPECIFIED IN ITS CHARTER)

                  DELAWARE                                    63-6006515
       (STATE OR OTHER JURISDICTION OF                     (I.R.S. EMPLOYER
       INCORPORATION OR ORGANIZATION)                     IDENTIFICATION NO.)

               3275 HIGHWAY 30                                   36016
              CLAYTON, ALABAMA                                 (ZIP CODE)
  (ADDRESS OF PRINCIPAL EXECUTIVE OFFICES)

       REGISTRANT'S TELEPHONE NUMBER, INCLUDING AREA CODE: (334) 775-1400

           SECURITIES REGISTERED PURSUANT TO SECTION 12(B) OF THE ACT:


                                                 NAME OF EACH EXCHANGE ON
         TITLE OF EACH CLASS                         WHICH REGISTERED
       -------------------------                 ------------------------
                NONE                                      NONE


          SECURITIES REGISTERED PURSUANT TO SECTION 12(G) OF THE ACT:

                     COMMON STOCK, PAR VALUE $.001 PER SHARE
                                (TITLE OF CLASS)


         INDICATE BY CHECK MARK WHETHER THE REGISTRANT (1) HAS FILED ALL REPORTS
REQUIRED TO BE FILED BY SECTION 13 OR 15(D) OF THE SECURITIES EXCHANGE ACT OF
1934 DURING THE PRECEDING 12 MONTHS (OR FOR SUCH SHORTER PERIOD THAT THE
REGISTRANT WAS REQUIRED TO FILE SUCH REPORTS), AND (2) HAS BEEN SUBJECT TO SUCH
FILING REQUIREMENTS FOR THE PAST 90 DAYS. YES [X]   NO [ ]

         AGGREGATE MARKET VALUE OF THE VOTING AND NON-VOTING COMMON EQUITY HELD
BY NON-AFFILIATES OF THE REGISTRANT:

                         $1,393,611 AS OF MARCH 23, 2001

         INDICATE THE NUMBER OF SHARES OUTSTANDING OF EACH OF THE REGISTRANT'S
CLASSES OF COMMON STOCK, AS OF THE LATEST PRACTICABLE DATE.

          2,894,919 SHARES OF COMMON STOCK, PAR VALUE $.001 PER SHARE,
                       OUTSTANDING AS OF MARCH 23, 2001.

                       DOCUMENTS INCORPORATED BY REFERENCE

         DOCUMENTS INCORPORATED BY REFERENCE IN THIS ANNUAL REPORT ON FORM 10-K
ARE AS FOLLOWS:

PORTIONS OF THE DEFINITIVE PROXY STATEMENT RELATING TO THE 2001 ANNUAL MEETING
OF STOCKHOLDERS IN PART III, ITEMS 10 (AS RELATED TO DIRECTORS), 11, 12 AND 13.
PORTIONS OF THE ANNUAL REPORT TO STOCKHOLDERS FOR THE YEAR ENDED DECEMBER 31,
2000 IN PARTS II AND IV.

         INDICATE BY CHECK MARK IF DISCLOSURE OF DELINQUENT FILERS PURSUANT TO
ITEM 405 OF REGULATION S-K IS NOT CONTAINED HEREIN, AND WILL NOT BE CONTAINED,
TO THE BEST OF REGISTRANT'S KNOWLEDGE, IN DEFINITIVE PROXY OR INFORMATION
STATEMENTS INCORPORATED BY REFERENCE IN PART III OF THIS FORM 10-K OR ANY
AMENDMENT TO THIS FORM 10-K. [ ]

===============================================================================

<PAGE>   2

                                     PART I
ITEM 1.  BUSINESS

THE COMPANY

         Boyd Bros. Transportation Inc. ("Boyd" or the "Company") is a truckload
carrier that operates exclusively in the flatbed segment of the industry and
hauls primarily steel products and building materials. Since its founding in
1956, Boyd has grown into what management believes is one of the largest
exclusively flatbed carriers in the United States. The Company owns and operates
a total of over 1,017 tractors and 1,398 flatbed trailers.

         On December 8, 1997, Boyd acquired Welborn Transport, Inc. ("Welborn")
located in Tuscaloosa, Alabama (the "Welborn Acquisition"). The acquisition was
accounted for using the purchase method of accounting and, accordingly, the
purchase price was allocated to the assets acquired, and liabilities assumed,
based upon their estimated fair market values at the acquisition date. Welborn
is operated by Boyd as a stand-alone subsidiary. References to the "Company"
contained herein refer to the combined operations of Boyd and Welborn.
References hereinafter to "Boyd" or "Welborn" describe the distinct operations
of the parent and subsidiary, respectively.

         The Company's strategy is to offer high-quality flatbed transportation
services to high-volume, time-sensitive shippers. Because much of the freight
hauled by the Company consists of steel products and building materials,
time-definite delivery is required. A late delivery can result in a shutdown of
a production line at a plant or a delay in a construction project. Management
focuses its marketing efforts on those shippers who require time-definite
delivery because it believes that service, rather than price, generally will be
the primary factor that will dictate their choice of carrier.

         Management believes that its ability to recruit and retain drivers has
been critical to its success, and Boyd has sought to attract and retain drivers
by using only high quality, late-model tractors equipped with its two-way
satellite communication equipment, and offering financial and other incentives
to drivers. Management recognizes that getting drivers home frequently is
critical to driver retention. Accordingly, Boyd makes load assignments to
drivers that enable each driver to attain his or her goals with respect to both
miles driven as well as time at home.

         Additionally, in June 1997, Boyd began contracting with independent
owner-operators to provide service to its customers. Boyd has also implemented a
lease-purchase program, providing Boyd's drivers with both career opportunities
at Boyd and the opportunity to own their own tractor. Under the program, the
driver leases the tractor from Boyd, along with an option to purchase the
tractor. In turn, the driver leases the use of the tractor and the driver's
services back to Boyd.

         In 1998, Boyd added another option under the owner-operator program.
Owner-operators are able to lease a new tractor for three and one-half years.
Boyd will retain ownership of the tractor at the end of the lease, but this will
enable the owner-operator to operate a new tractor and maintain his or her
status as an independent contractor.

         Welborn provides transportation services over shorter routes than
traditionally provided by Boyd. Welborn operates primarily in the southeastern
United States, with an average length of haul of less than 400 miles. Management
believes this enhances Welborn's ability to retain quality drivers, as drivers'
time away from home is thereby minimized. Welborn operates approximately 191
tractors and over 275 flatbed trailers. Owner-operators own 161 of the 191
tractors utilized by Welborn, while Welborn owns the rest. The owner-operators
of these units are compensated by Welborn based upon a percentage of revenue.
Welborn utilizes agents in some areas to solicit and book freight. During 2000,
the Company closed its Welborn logistics unit and reopened it at the Boyd
division, and Welborn closed its specialized over-dimensional transport unit due
to a slowdown in freight and a reduction in overall profitability.

STRATEGY

         As discussed above, the Company's business strategy is to offer
high-quality flatbed transportation services in the truckload carrier market
primarily to high-volume, time-sensitive customers. The key components of the
Company's strategy are as follows:


<PAGE>   3

         Time-Sensitive Shippers. The Company focuses its marketing efforts on
high-volume, time-sensitive shippers that are involved primarily in the steel
and building materials businesses and require time-definite delivery. Management
believes that many large volume shippers in this segment of the industry have
reduced the number of carriers they use to only those "core carriers" that offer
consistently superior service. The Company intends to continue its focus on
developing relationships as a core-carrier for high-volume, time-sensitive
shippers.

         Technology. Boyd's strategy has been to utilize technology to provide
better service to its customers and to improve operating efficiency. Boyd
utilizes satellite-tracking systems that enable Boyd to monitor equipment
locations and schedules more effectively and to communicate with both drivers
and customers. Customers are also able to track their loads by utilizing Boyd's
technology. Boyd has also installed computers on board each of its tractors to
monitor fuel efficiency and other operational data. Boyd will continue to
monitor and implement technological developments that will enable it to improve
customer service and operating efficiency.

         Premium Quality Tractors. Boyd continuously upgrades its fleet of
tractors. Boyd's management believes that maintaining a young, high-quality
fleet of tractors facilitates Boyd's ability to recruit and retain drivers,
achieve maximum on-time reliability, maximize fuel economy and convey an image
of quality to existing and potential customers. While Welborn maintains a fleet
of high-quality tractors, the shorter routes over which its vehicles are
dispatched enables these units to be serviced more frequently. Accordingly, it
has not been necessary for Welborn to replace its fleet as frequently as Boyd.

CUSTOMERS AND MARKETING

         The Company markets itself on the basis of quality service and
employees, its satellite communication system, the capabilities of its
information system to interface with the information systems of its customers,
its record of on-time deliveries, and its efficient and well-maintained tractors
and trailers. The Company's marketing efforts concentrate on attracting
customers that require time-definite delivery and ship multiple loads to and
from locations that complement the Company's existing traffic flows.

         Boyd has written contracts with most of its customers. The contracts
generally require the customer to use Boyd for a specified minimum amount of
shipments each year and may be terminated by either party upon 30 to 60 days'
written notice.

         The Company's largest 25, 10 and 5 customers accounted for
approximately 54.2%, 38.9% and 27.3% respectively, of the Company's revenues
during the year ended December 31, 2000. Many of the Company's largest 25
customers are publicly held companies. No single customer accounted for more
than 10% of the Company's revenues during the year ended December 31, 2000.

OPERATIONS

         The Company's operations are designed to maximize efficiency and
provide quality service to customers. All of Boyd's fleet operations, routing
and scheduling are centrally coordinated through a satellite tracking system
from its corporate headquarters in Clayton, Alabama. Through the use of Boyd's
satellite-based communication system, which is complemented by its fully
integrated mainframe computer system, dispatchers monitor the location and
delivery schedules of all shipments and equipment to coordinate routes and
maximize utilization of Boyd's drivers and equipment. See "Transportation
Technology."

         Boyd conducts its operations through a network of 9 regional and
satellite service centers in strategic locations in the eastern two-thirds of
the United States. See "Item 2 - Properties." Boyd operates regional service
centers in Clayton and Birmingham, Alabama; Springfield, Ohio; and Greenville,
Mississippi. These regional service centers are supported by smaller satellite
service centers, each having between one to three employees, located in Calvert
City, Kentucky; Danville, Virginia; Lisbon Falls, Maine; Conley, Ga.; and
Walworth, Wisconsin. These service centers allow Boyd to re-dispatch equipment
terminating in a given area, enhance driver recruitment and return drivers to
their homes more regularly. Boyd also has arrangements to deposit trailers near
various major customers or shipping locations to facilitate pre-loading of
shipments and thereby increase efficiency.


                                       2
<PAGE>   4

         Welborn's corporate offices are located in Tuscaloosa, Alabama. Welborn
utilizes independent agents located in Atlanta, Georgia; Houston, Texas;
Knoxville, Tennessee; Weirton, West Virginia; and Fort Myers, Florida.

DRIVERS AND EMPLOYEES

         Recruiting and retaining professional, well-trained drivers is critical
to the Company's success, and all of the Company's drivers must meet specific
guidelines relating primarily to safety records, driving experiences and
personal evaluations, including drug testing.

         To maintain high equipment utilization, particularly during periods of
growth, the Company strongly emphasizes continuous driver and owner-operator
recruitment and training. Drivers are recruited at all of the Company's regional
terminal locations and primarily at the Company's corporate headquarters.
Drivers attend orientation at the Birmingham terminal.

         Drivers are trained in Company policies and operations, safety
techniques and fuel-efficient operation of equipment. In addition, each driver
must pass a rigorous road test prior to his or her assignment to a vehicle. The
Company believes that experienced drivers have better safety records than new
driver-school graduates, and management believes that their skills will help
Boyd improve overall fleet efficiency as a result of higher utilization and
historically lower maintenance costs on tractors operated by experienced
drivers. As a result, beginning in February 2001 Boyd began hiring only
experienced drivers and has discontinued hiring drivers from drivers school. All
drivers are required to participate in annual safety training and defensive
driving courses for re-certification by the Company. Recognizing the importance
of driver contact while drivers are on the road for extended periods, the
Company maintains toll-free telephone lines and publishes a newsletter
containing Company information, in addition to maintaining daily contact between
dispatchers and drivers.

         Competition for qualified drivers is intense. The short- to medium-haul
truckload segment of the trucking industry, including the Company, experiences
significant driver and owner-operator turnover, and the Company anticipates that
the intense competition for qualified drivers in the trucking industry will
continue. In order to attract quality drivers, management is actively pursuing
the services of independent owner-operators to complement its fleet.

         At December 31, 2000, the Company had 962 employees; of these,
approximately 745 were Company drivers, and the balance were mechanics, other
equipment maintenance personnel and support personnel, including management and
administration. In addition, owner-operators accounted for the operation of
approximately 272 tractors. None of the Company's employees is subject to a
collective bargaining agreement, and the Company has never experienced a work
stoppage. Management believes that its relationship with its employees is good.

REVENUE EQUIPMENT

         The Company's philosophy is to purchase premium quality tractors to
help attract and retain drivers and to promote safe operations, and management
believes the higher initial cost of such equipment is recovered through better
resale marketability. Each of the Company's tractors are equipped with a sleeper
cab to permit all drivers to comply conveniently and cost-effectively with the
United States Department of Transportation ("DOT") hours of service guidelines
and to facilitate team operations when necessary.

         At December 31, 2000, the Company owned and operated 1,017 tractors and
1,398 flatbed trailers. The tractors are manufactured by Freightliner and
International, and the trailers are manufactured by Utility, Dorsey, Fontaines,
Wabash and Great Dane.

TRANSPORTATION TECHNOLOGY

         Management believes that the application of technology is an ongoing
part of providing high-quality service at competitive prices, and further
believes that Boyd has enhanced its strong reputation for customer satisfaction
through the early and fleet-wide implementation of its satellite systems as well
as its tracking and load tendering ability.


                                       3
<PAGE>   5

         Boyd's satellite system permits more efficient transmission of load
assignments to drivers, and enhances the Company's ability to monitor loads in
transit and rapidly bill customers for completed deliveries. Once a load planner
assigns a load, the assignment is transmitted to Boyd's operations department
where it is reviewed by a dispatcher who then relays the assignment to the
appropriate driver through the display unit in each of Boyd's vehicles. The
driver can respond to the dispatcher in a matter of seconds, thereby eliminating
waiting time and inefficient dependence on truck stop telephones or other
methods of communication between drivers and dispatchers. Boyd can
electronically record a load assignment, report the load to the billing
department and generate customer invoices.

         In addition, Boyd uses the satellite system to automatically transmit
location and equipment information and other data to the dispatcher, thereby
reducing the need for drivers to stop to communicate with dispatchers in the
event of a problem. The system continually tracks every cargo load with accuracy
within one-tenth of a mile. This information, along with information concerning
available loads, is constantly updated on Boyd's on-line computer. Load planners
use this information to match available equipment with available loads, meet
delivery schedules and respond more quickly to customer inquiries. Customers are
able to access and track their loads through Boyd's internet web site.

         Boyd has also equipped its entire fleet of tractors with the
SENSORTRACS(C) on-board computer system ("Sensortracs"). This system monitors
fuel efficiency and other operational data. Information from Sensortracs is
periodically processed by one of Boyd's computers, which generates reports on
vehicle efficiency and driver performance. Reports generated by this system
enhance Boyd's ability to counsel its drivers on strengths and deficiencies in
their driving habits and fuel efficiency and to monitor the effectiveness of
driver training programs.

         During 1998, Boyd developed load tendering and tracking capabilities.
Customers are able to track the progress of their loads during transport using
their own personal computer. Additionally, customers are able to book loads over
the internet. Customers submit potential loads to the appropriate regional load
planner, and the load planner will then contact the customer via the Internet
e-mail system to acknowledge acceptance of the load. This technological
advancement enables customers to book loads routinely without having to complete
the same paperwork again. Additionally, Boyd utilizes a software program by The
LOGISTICS.COM Group that enables Boyd to review each shipping lane to determine
overall profitability and also to determine which customers are the most
profitable within the lane. The Company's management believes that as a result
of these enhanced capabilities, Boyd will be in a position to direct the
movement of the fleet in a way that will yield the most results to the bottom
line without affecting the quality of the service.

SAFETY AND INSURANCE

         The Company's safety department is responsible for training and
supervising personnel to keep safety awareness at its highest level. The Company
has implemented an active safety and loss prevention program. The emphasis on
safety begins in the hiring and training process, where prospective employees
and owner-operators are given physical examinations and drug tests, and newly
hired drivers and owner-operators, regardless of experience level, must
participate in an intensive orientation program. See "Drivers and Employees."

         The directors of safety for the Company continuously monitor driver
performance and have final authority regarding employment and retention of
drivers. The Company is committed to securing appropriate insurance coverage at
cost-effective rates. The primary claims that arise in the trucking industry
consist of cargo loss and damage, personal injury, property damage and workers'
compensation. The Company retains liability up to $100,000 for each claim for
personal injury and property damage, $100,000 for each claim for employee
medical and hospitalization, and $10,000 for each claim for cargo damage. The
Company is self insured for workers' compensation claims as well as physical
damage claims for its own tractors. The Company currently purchases excess
primary and umbrella insurance coverage in amounts that management believes are
adequate to supplement its retained liabilities. The Company will be facing an
increase in its auto and insurance rates during the second half of 2001. These
rates could increase as much as 25%, and in addition to an increase in the
retention per occurrence.


                                       4
<PAGE>   6

FUEL

         Motor carrier service is dependent upon the availability of diesel
fuel. The Company's fuel expense comprised 11.2% and 8.7% of revenues in 2000
and 1999, respectively. Through on-board computers, the Company continually
monitors fuel usage, miles per gallon, cost per mile and cost per gallon. The
Company has not experienced any difficulty in maintaining fuel supplies
sufficient to support its operations. Shortages of fuel, increases in fuel
prices or fuel tax rates or rationing of petroleum products could have a
material adverse effect on the operations and profitability of the Company.
Because of the high cost of fuel in 2000, the Company has implemented a fuel
surcharge program with most of its customers.

COMPETITION

         The trucking industry is highly competitive and fragmented. The Company
competes primarily with other short- to medium-haul, flatbed truckload carriers,
internal shipping conducted by existing and potential customers and, to a lesser
extent, railroads. Deregulation of the trucking industry during the 1980s
created an influx of new truckload carriers, which along with certain other
factors, continues to create substantial downward pressure on the industry's
rate structure. Competition for the freight transported by the Company is based
primarily on service and efficiency and, to a lesser degree, on freight rates.
There are other trucking companies, including truckload carriers that have
flatbed divisions that have substantially greater financial resources, operate
more equipment or carry a larger volume of freight than the Company. The
existence of these other motor carriers has also resulted in increased
competition for hiring and retaining qualified drivers.

REGULATION

         The trucking industry is subject to regulatory oversight and
legislative changes that can affect the economics of the industry by requiring
certain operating practices or influencing the demand for, and the costs of
providing, services to shippers. The Intermodal Surface Transportation Board
(the "ISTB"), as well as various state agencies that have jurisdiction over the
Company, have broad powers, generally governing such matters as authority to
engage in motor carrier operations, rates and charges, accounting systems,
certain mergers, consolidations and acquisitions, and periodic financial
reporting.

         The Federal Motor Carrier Act of 1980 commenced a program to increase
competition among motor carriers and to diminish the level of regulation in the
industry. Following this deregulation, applicants have more easily been able to
obtain operating authority, and interstate motor carriers such as the Company
have been able to implement certain rate changes without federal approval. The
Motor Carrier Act also removed many route and commodity restrictions on
transportation of freight. In 1995, the Interstate Commerce Commission (the
"ICC") was eliminated, and the ISTB was established within the Department of
Transportation (the "DOT"). The ISTB performs all functions previously performed
by the ICC. Since 1981, the Company has held authority to carry general
commodities throughout the 48 contiguous states, as both a common and contract
carrier.

         Interstate motor carrier operations are subject to safety requirements
prescribed by the DOT. Such matters as weight and dimensions of equipment are
also subject to federal and state regulation. All of the Company's drivers were
required to obtain national commercial driver's licenses by April 1, 1992
pursuant to the regulations promulgated by the DOT. Also, effective in 1989, DOT
regulations imposed mandatory drug testing of drivers. In addition, the Company
has completed the implementation of its own ongoing drug-testing program. The
DOT's national commercial driver's license and drug testing requirements have
not to date adversely affected the availability of qualified drivers to the
Company. DOT alcohol testing rules require certain tests, random and otherwise,
for alcohol levels in drivers and other safety personnel. See "Safety and
Insurance."

ENVIRONMENTAL MATTERS

         The Company's operations are subject to federal, state and local laws
and regulations concerning the environment. Certain of the Company's facilities
are located in historically industrial areas and, therefore, there is the
possibility of environmental liability as a result of operations by prior owners
as well as the Company's use of fuels and underground storage tanks at its
regional service centers.


                                       5
<PAGE>   7

         Currently, management does no know of any environmental remediation
issues or liabilities. There can be no assurance that material liabilities or
expenditures will not arise from these or additional environmental matters that
may be discovered, or from future requirements of law. Management does not
believe these expenditures will have a material adverse effect on the Company's
financial condition.

FORWARD LOOKING STATEMENTS

         Certain of the statements contained in this report constitute
"forward-looking statements" within the meaning of the Private Securities
Litigation Reform Act of 1995. Such forward-looking statements involve known and
unknown risks, uncertainties and other factors which may cause the actual
results, performance, or achievements of the Company to be materially different
from any future results, performance or achievements expressed or implied by
such forward-looking statements. Such factors include, among other things,
business conditions and growth in the economy, including the transportation and
construction sectors in particular, competitive factors, including price
pressures and the ability to recruit and retain qualified drivers, the ability
to control internal costs, particularly fuel costs which have continued to rise
materially during 2000 that may or may not be passed on to the Company's
customers, departures and defaults by owner-operators, the cost of complying
with governmental regulations that are applicable to the Company, and other
factors referenced elsewhere herein.

ITEM 2.  PROPERTIES

         The Company's corporate headquarters and principal service center are
located on a 17.9-acre tract in Clayton, Alabama. These facilities consist of
approximately 22,000 square feet of office space, 12,000 square feet of
equipment repair facilities and approximately 3 acres of parking space. During
2000, the Company completed the construction of an 80,000 sq. ft. terminal in
Birmingham, Alabama, which contains several maintenance and safety bays.

         The following table sets forth information regarding the location and
ownership of each of Boyd's service centers and shuttle facilities:

<TABLE>
                  <S>                                                                    <C>
                  Clayton, AL........................................................     Owned
                  Springfield, OH....................................................     Owned
                  Birmingham, AL.....................................................     Owned
                  Greenville, MS.....................................................     Owned
                  Calvert City, KY...................................................    Leased
                  Danville, VA.......................................................    Leased
                  Lisbon Falls, ME...................................................    Leased
                  Conley, GA.........................................................    Leased
                  Walworth, WI.......................................................    Leased
</TABLE>


Additionally, Welborn owns its corporate offices in Tuscaloosa, Alabama and
leases service centers located as follows:

<TABLE>
                  <S>                                                                    <C>
                  Birmingham, AL.....................................................    Leased
                  Atlanta, GA........................................................    Leased
</TABLE>

ITEM 3.  LEGAL PROCEEDINGS

         The Company is routinely a party to litigation incidental to its
business, primarily involving claims for personal injury and property damage
incurred in the transportation of freight. The Company maintains insurance that
it believes is adequate to cover its liability risks. See "Item 1 - Business --
Safety and Insurance."

ITEM 4.  SUBMISSION OF MATTERS TO A VOTE OF SECURITY HOLDERS

         No matters were submitted to a vote of security holders during the
fourth quarter of the year ended December 31, 2000, either through the
solicitation of proxies or otherwise.


                                       6
<PAGE>   8

                                     PART II

ITEM 5.  MARKET FOR REGISTRANT'S COMMON EQUITY AND RELATED STOCKHOLDER MATTERS

         The Common Stock of the Company is listed on The Nasdaq SmallCap Market
under the symbol "BOYD". In May 2000, Nasdaq notified the Company that its
Common Stock no longer met certain requirements necessary for continued listing
on the Nasdaq National Market. In response to this development, the Company
elected to voluntarily transfer its Common Stock from the Nasdaq National Market
to the Nasdaq SmallCap Market. This transfer became effective, and the Company's
Common Stock began trading on the Nasdaq SmallCap Market, on August 30, 2000. As
of March 16, 2001, the Common Stock was held by approximately 75 holders of
record. The table below sets forth the reported high and low sales price per
share for the Common Stock as reported by the Nasdaq National Market or the
Nasdaq SmallCap Market, as applicable, for each fiscal quarter during 2000 and
1999.

<TABLE>
<CAPTION>
                                                                  Price Range
                                                             --------------------
      2000                                                     High         Low
      ----                                                   --------------------
      <S>                                                    <C>           <C>
      First Quarter.....................................      $7.38        $5.00
      Second Quarter....................................       6.00         4.13
      Third Quarter.....................................       4.75         3.56
      Fourth Quarter....................................       4.25         2.38
</TABLE>


<TABLE>
<CAPTION>
                                                                   Price Range
                                                             --------------------
      1999                                                     High         Low
      ----                                                   --------------------
      <S>                                                    <C>           <C>
      First Quarter.....................................     $ 8.38        $6.13
      Second Quarter....................................      11.75         7.75
      Third Quarter.....................................      11.63         8.75
      Fourth Quarter....................................       9.75         6.13
</TABLE>

         Management currently anticipates that all of its earnings will be
retained for development of the Company's business and does not anticipate
paying any cash dividends in the foreseeable future. Future cash dividends, if
any, will be at the discretion of the Company's Board of Directors and will
depend upon, among other things, the Company's future operations and earnings,
capital requirements and surplus, general financial condition, contractual
restrictions, and other factors as the Board of Directors may deem relevant.

         Pursuant to the Company's stock repurchase program, the Company
purchased 263,940 and 370,463 shares of the common stock in open market or
negotiated transactions during 1999 and 2000, for aggregate purchase prices of
$2,342,746 and $2,248,941, respectively, including an aggregate 126,000 shares
of Common Stock purchased from Miller Welborn, the Vice-Chairman of the Company,
during 2000 at a price per share of $6.50. The Company funded these purchases
using working capital. On January 8, 1999, the Company purchased 500,000 shares
of its outstanding common stock from a former Chief Executive Officer of the
Company for $3,660,000. The stock purchase was funded by available cash and a
bank line of credit.

ITEM 6.  SELECTED FINANCIAL DATA

         The information required by this item is incorporated by reference from
the information under the caption "Selected Financial Data" in the Company's
Annual Report to Stockholders for the year ended December 31, 2000.

ITEM 7.  MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND
         RESULTS OF OPERATIONS

         The information required by this item is incorporated by reference from
the information under the caption "Management's Discussion and Analysis of
Financial Condition and Results of Operations" in the Company's Annual Report to
Stockholders for the year ended December 31, 2000.


                                       7
<PAGE>   9



ITEM 7A. QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK

INTEREST RATE RISK

         The Company is exposed to interest rate risk due to its long-term debt,
which at December 31, 2000, bore interest at rates ranging from 1.25% to 1.75%
above the applicable bank's LIBOR rate. Under the provisions of Statement of
Financial Accounting Standards ("SFAS") No. 107, Disclosures about Fair Value of
Financial Instruments, the Company has estimated the fair value of its long-term
debt approximates its carrying value, using a discounted cash flow analysis
based on borrowing rates available to the Company. The effect of a hypothetical
ten percent increase in interest rates would increase the estimated fair value
of the Company's long-term debt by approximately $640,000. Management believes
that current working capital funds are sufficient to offset any adverse effects
caused by changes in these interest rates.

ITEM 8.  FINANCIAL STATEMENTS AND SUPPLEMENTARY DATA

         The information required by this item is incorporated by reference from
the Consolidated Financial Statements contained in the Company's Annual Report
to Stockholders for the year ended December 31, 2000.

ITEM 9.  CHANGES IN AND DISAGREEMENTS WITH ACCOUNTANTS ON ACCOUNTING AND
         FINANCIAL DISCLOSURE

         None.

                                    PART III

ITEM 10. DIRECTORS AND EXECUTIVE OFFICERS OF THE REGISTRANT

         Set forth below is information concerning the Executive Officers of the
Company as of March 16, 2001. Additional information required by Part III, Item
10 is incorporated herein by reference to the Company's definitive Proxy
Statement relating to the 2001 Annual Meeting of Stockholders, which is
scheduled to be filed on or before April 12, 2001.

         Dempsey Boyd, age 73, founded Boyd in 1956, and has been Chairman of
the Board since April 1980. Mr. Boyd served as President of Boyd from December
1962 until April 1980. Mr. Boyd is the father of Gail B. Cooper and Ginger B.
Tibbs.

         Gail B. Cooper, age 50, has served as President and Chief Executive
Officer and as a Director of the Company since February 17, 2000. Ms. Cooper
served as Secretary of Boyd from December 1969 until February 2000. Ms. Cooper
received a B.S. in business administration from Troy State University. She has
served Boyd in numerous administrative and accounting positions since joining
Boyd full-time in June 1972. Ms. Cooper is the daughter of Mr. Boyd and the
sister of Ms. Tibbs.

         Richard C. Bailey, age 50, has served as Executive Vice President and
Chief Financial Officer of the Company since joining Boyd in August 1992, and
has served as a Director since February 1995. He served as President and
Director of Eastern Inter-Trans Services, Inc., a dry van truckload carrier
based in Columbus, Georgia, from December 1989 to August 1992. Mr. Bailey is a
certified public accountant with a B.S. in accounting from Georgia State
University. He was previously employed in various financial positions by Ernst &
Young, Intermet Corporation and Snapper Products (a division of The Actava Group
Inc.). Mr. Bailey has served on the Advisory Board of the University of Georgia
Trucking Profitability Strategies Conference.

         Ginger B. Tibbs, age 47, has been the Secretary/Treasurer of Boyd since
February 2000, and served as a Director from December 1978 until March 1994. Ms.
Tibbs is primarily responsible for collection of Boyd's accounts receivable and
has served as Credit Manager since September 1980. Ms. Tibbs received a degree
in elementary education from Auburn University. She is the daughter of Mr. Boyd
and the sister of Ms. Cooper.


                                       8
<PAGE>   10



ITEM 11. EXECUTIVE COMPENSATION

         All information required by Item 11 is incorporated by reference to the
Company's definitive Proxy Statement relating to the 2001 Annual Meeting of
Stockholders, which is scheduled to be filed on or before April 12, 2001.

ITEM 12. SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT

         All information required by Item 12 is incorporated by reference to the
Company's definitive Proxy Statement relating to the 2001 Annual Meeting of
Stockholders, which is scheduled to be filed on or before April 12, 2001.

ITEM 13. CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS

         All information required by Item 13 is incorporated by reference to the
Company's definitive Proxy Statement relating to the 2001 Annual Meeting of
Stockholders, which is scheduled to be filed on or before April 12, 2001

                                     PART IV

ITEM 14. EXHIBITS, FINANCIAL STATEMENTS, FINANCIAL STATEMENT
              SCHEDULES AND CURRENT REPORTS ON FORM 8-K

(a)      Exhibits, Financial Statements and Schedules.

         1.       Financial Statements. The following financial statements for
         the Company and Independent Auditors' Report are incorporated by
         reference from the Company's Annual Report to Stockholders for the year
         ended December 31, 2000:

                  Independent Auditors' Report
                  Consolidated Balance Sheets at December 31, 2000 and 1999
                  Consolidated Statements of Operations for the years ended
                     December 31, 2000, 1999 and 1998
                  Consolidated Statements of Stockholders' Equity for the years
                     ended December 31, 2000, 1999 and 1998
                  Consolidated Statements of Cash Flows for the years ended
                     December 31, 2000, 1999 and 1998
                  Notes to Consolidated Financial Statements

         2.       Financial Statement Schedules.

         The schedule listed below is included herein immediately after the
         signature pages hereto. Schedules not listed below have been omitted
         because of the absence of conditions under which they are required or
         because the information is included in the financial statements or
         notes thereto.

<TABLE>
<CAPTION>
         SCHEDULE
          NUMBER                                DESCRIPTION
         --------                               -----------
         <S>                         <C>
           II                        Valuation and Qualifying Accounts and Reserves for the Three Fiscal
                                     Years Ended December 31, 2000
</TABLE>


                                       9
<PAGE>   11

         3.       Exhibits required by Item 601 of Regulation S-K.

         The following exhibits are included in this Form 10-K:

<TABLE>
<CAPTION>
   EXHIBIT
      NO.         DESCRIPTION
   -------        -----------
   <S>            <C>
    10.1          Credit and Security Agreement dated April 11, 2000 between the
                  Company and Compass Bank in the amount of $3,267,160 for truck
                  equipment

    10.2          Security Agreement dated April 11, 2000 between the Company and
                  Compass Bank in the amount of $3,267,160 for truck equipment

    10.3*         First Amendment to Acquisition Agreement, Employment Agreement and
                  Covenant Not To Compete dated March 17, 2000 between the Company,
                  Miller Welborn and Steven Rumsey

    10.4          Second Amendment to Acquisition Agreement dated May 30, 2000 between
                  the Company,  Miller Welborn and Steven Rumsey

    10.5*         Second Amendment to Employment Agreement dated May 22, 2000 between
                  the Company and Steven Rumsey

    10.6          Consulting Agreement dated June 1, 2000 between the Company and
                  Miller Welborn

    10.7          Master Note for Business and Commercial Loans dated July 7, 2000
                  between the Company and Amsouth Bank in the amount of $2,500,000.

    10.8          Debt Covenant Waiver dated March 27, 2001 from Compass Bank
                  relating to Credit and Security Agreement dated April 11,
                  2000.

    10.9          Waiver and Consent Agreement dated March 28, 2001 by and
                  between the Company and AmSouth Bank N.A. relating to Credit
                  Agreement dated April 1, 1994.

     13           Those portions of the Company's Annual Report to Stockholders
                  for the year ended December 31, 2000 that are specifically
                  incorporated herein by reference

     21           Subsidiaries of the Registrant

     23           Consent of Deloitte & Touche LLP
</TABLE>

                  The following exhibits are incorporated by reference to the
                  Company's Annual Report on Form 10-K for the year ended
                  December 31, 1999 (File No. 000-23948):



<TABLE>
<CAPTION>
   EXHIBIT
      NO.         DESCRIPTION
   -------        -----------
   <S>            <C>
    10.1          Credit and Security Agreement dated March 16, 1999 between the Company
                  and Compass Bank in the amount of $10,000,000 for truck equipment

    10.2          Security Agreement dated March 16, 1999 between the Company and Compass
                  Bank in the amount of $10,000,000 for truck equipment

</TABLE>



-------------------
*        Identifies each exhibit that is a "management contract or compensatory
         plan or arrangement" required to be filed as an exhibit to this Annual
         Report on Form 10-K pursuant to Item 14(c) of Form 10-K.


                                           10
<PAGE>   12
<TABLE>
   <S>            <C>
    10.3          Master Note for Business and Commercial Loans dated April 9, 1999
                  between the Company and Amsouth Bank in the amount of $2,500,000.

    10.3          Master Note for Business and Commercial Loans dated April 9, 1999
                  between the Company and Amsouth Bank in the amount of $1,750,000.
</TABLE>

         The following exhibits are incorporated by reference to the Company's
Annual Report on Form 10-K for the year ended December 31, 1998 (File No.
000-23948):


<TABLE>
<CAPTION>
   EXHIBIT
      NO.         DESCRIPTION
   -------        -----------
   <S>            <C>
    10.1          Credit and Security Agreement dated February 28, 1996 between the
                  Company and Compass Bank in the amount of $5,000,000 for truck equipment

    10.2          Credit and Security Agreement dated May 29, 1998 between the Company and
                  Compass Bank in the amount of $4,500,000 for truck equipment

    10.3*         Agreement and General Release between the Company and Donald Johnston
                  dated July 16, 1998

    10.4          Consulting Agreement between the Company and Donald Johnston dated
                  July 16, 1998

    10.5          Stock Repurchase Agreement between the Company and Donald Johnston dated
                  January 7, 1999
</TABLE>


         The following exhibits are incorporated by reference to the Company's
Annual Report on Form 10-K for the year ended December 31, 1997 (File no.
000-23948):

<TABLE>
<CAPTION>
   EXHIBIT
      NO.         DESCRIPTION
   -------        -----------
   <S>            <C>
   10.1*          First Amendment to Boyd Bros. Transportation Inc. 1994 Stock Option Plan

   10.2*          Employment Agreement between the Company and Miller Welborn dated
                  December 8, 1997

   10.3*          Employment Agreement between the Company and Steven Rumsey dated
                  December 8, 1997
</TABLE>

         The following exhibit is incorporated by reference to the Company's
Registration Statement on Form S-8 (File No. 333-78925), declared effective on
May 20, 1999:

<TABLE>
<CAPTION>
   EXHIBIT
      NO.         DESCRIPTION
   -------        -----------
   <S>            <C>
      4           Boyd Bros. Transportation Inc. 1999 Employee Stock Purchase Plan
</TABLE>

                                       11

<PAGE>   13
         The following exhibits are incorporated by reference to the Company's
Registration Statement on Form S-1 (File No. 33-76756), declared effective on
May 9, 1994:

<TABLE>
<CAPTION>
   EXHIBIT
      NO.         DESCRIPTION
   -------        -----------
   <S>            <C>
    3.1           Certificate of Incorporation of the Company

    3.2           By-laws of the Company

   10.1*          Boyd Bros. Transportation Inc. 1994 Stock Option Plan

   10.2*          Form of the Company's Nonstatutory Stock Option Agreement

   10.3*          Form of the Company's Nonstatutory Stock Option Agreement for
                  Nonemployee Directors

   10.37          Credit Agreement dated April 1, 1994 by and between the Company
                  and AmSouth Bank N.A.

</TABLE>




      The following exhibit is incorporated by reference to the Company's
Amendment to Report on Form 10-Q filed on August 5, 1997:

<TABLE>
<CAPTION>
   EXHIBIT
      NO.         DESCRIPTION
   -------        -----------
   <S>            <C>
  10.33           OMNITRACS contract dated February 5, 1997, between the Company and
                  QUALCOMM, Inc.
</TABLE>

       The following exhibit is incorporated by reference to the Company's
Report on Form 8-K filed on December 19, 1997:

<TABLE>
<CAPTION>
   EXHIBIT
      NO.         DESCRIPTION
   -------        -----------
   <S>            <C>
   2.1            Acquisition Agreement dated December 8, 1997, by and among the Company,
                  W-T Acquisition Company, Welborn Transport, Inc., Miller Welborn and
                  Steven Rumsey
</TABLE>

(b)      Reports on Form 8-K

         None.


                                       12
<PAGE>   14


                                   SIGNATURES


         Pursuant to the requirements of Section 13 or 15(d) of the Securities
Exchange Act of 1934, the Registrant has duly caused this report to be signed on
its behalf by the undersigned, thereunto duly authorized.


                                   BOYD BROS. TRANSPORTATION INC.

                                   By:  /s/ GAIL B. COOPER
                                      ---------------------------------------
                                        Gail B. Cooper
                                        President and Chief Executive Officer


Date:  March 30, 2001

         Pursuant to the requirements of the Securities Exchange Act of 1934,
this report has been signed below by the following persons on behalf of the
Registrant and in the capacities and on the dates indicated:

<TABLE>
<CAPTION>
           SIGNATURES                               TITLE                               DATE
           ----------                               -----                               ----
<S>                                      <C>                                        <C>
/s/ GAIL B. COOPER
-------------------------------
        Gail B. Cooper                   Chief Executive Officer, President         March 30, 2001
                                         and Director (Principal
                                         Executive Officer)


 /s/ RICHARD C. BAILEY                   Executive Vice President,
-------------------------------          Chief Financial Officer and                March 30, 2001
      Richard C. Bailey                  Director (Principal Financial
                                         and Accounting Officer)


 /s/ DEMPSEY BOYD                        Chairman and Director                      March 30, 2001
-------------------------------
         Dempsey Boyd


  /s/ W. MILLER WELBORN                  Vice-Chairman and Director                 March 30, 2001
-------------------------------
       W. Miller Welborn


  /s/ J. MARK DUNNING                    Director                                   March 30, 2001
-------------------------------
        J. Mark Dunning


 /s/ BOYD WHIGHAM                        Director                                   March 30, 2001
-------------------------------
         Boyd Whigham


 /s/ STEPHEN J. SILVERMAN                Director                                   March 30, 2001
-------------------------------
      Stephen J. Silverman


/s/  J. LARRY BAXTER                     Director                                   March 30, 2001
-------------------------------
       J. Larry Baxter
</TABLE>


                                       13
<PAGE>   15
INDEPENDENT AUDITORS' REPORT

To the Board of Directors and Stockholders of Boyd Bros.
  Transportation Inc.:


We have audited the consolidated financial statements of Boyd Bros.
Transportation Inc. and subsidiary as of December 31, 2000 and 1999, and the
related consolidated statements of operations, stockholders' equity, and cash
flows for each of the three years in the period ended December 31, 2000, and
have issued our report thereon dated February 9, 2001 (March 28, 2001 as to the
waiver letters described in Note 4); such consolidated financial statements and
report are included in your 2000 Annual Report to Shareholders and are
incorporated herein by reference. Our audits also included the consolidated
financial statement schedule of Boyd Bros. Transportation Inc. and subsidiary,
listed in Item 14. This consolidated financial schedule is the responsibility of
the Company's management. Our responsibility is to express an opinion based on
our audits. In our opinion, such consolidated financial statement schedule, when
considered in relation to the basic consolidated financial statements as a
whole, presents fairly in all material respects the information shown therein.



Deloitte & Touche LLP

Birmingham, Alabama
February 9, 2001



<PAGE>   16
                                  SCHEDULE II
                         BOYD BROS. TRANSPORTATION INC.
                 VALUATION AND QUALIFYING ACCOUNTS AND RESERVES
               For the Three Fiscal Years Ended December 31, 2000



<TABLE>
<CAPTION>
                                                          Additions    Additions
                                            Balance at    Charged to   Charged to
                                           Beginning of   Costs and      Other                       Balance at
Description                                    Year        Expenses     Accounts     Deductions(a)   End of year
------------                               ------------   ----------   ----------    -------------   -----------
<S>                                        <C>            <C>          <C>           <C>             <C>
Allowance for doubtful accounts--deducted
from trade receivables in the balance sheet

   Year ended December 31, 1998             $  237,000    $  150,400   $     --        $  115,400      $272,000
                                            ==========    ==========   ==========      ==========      ========
   Year ended December 31, 1999             $  272,000    $  220,000   $     --        $  145,000      $347,000
                                            ==========    ==========   ==========      ==========      ========
   Year ended December 31, 2000             $  347,000    $   84,000   $     --        $  155,000      $276,000
                                            ==========    ==========   ==========      ==========      ========
</TABLE>


<TABLE>
<CAPTION>
                                                          Additions
                                            Balance at    Charged to
                                           Beginning of   Costs and                      Balance at
Description                                    Year        Expenses      Deductions(a)   End of year
------------                               ------------   ----------     -------------   -----------
<S>                                        <C>            <C>            <C>             <C>
Allowance for uncollectible receivables
related to sales-type leases--deducted
from investment in sales-type leases in
the balance sheet

   Year ended December 31, 1998              $  380,000   $1,627,506     $  806,261      $1,201,245
                                             ==========   ==========     ==========      ==========
   Year ended December 31, 1999              $1,201,245   $1,259,144     $1,549,635      $  910,754
                                             ==========   ==========     ==========      ==========
   Year ended December 31, 2000              $  910,754   $1,650,967     $1,883,812      $  677,909
                                             ==========   ==========     ==========      ==========
</TABLE>

(a) Uncollectible accounts written off