**Exhibit 31.1****CERTIFICATION**I, Steven A. Gould, M.D., Chief Executive Officer, certifythat:     1. I have reviewed this report onForm 10-K ofNorthfield Laboratories Inc. (the “Registrant”);     2. Based on my knowledge, this report does not contain anyuntrue statement of a material fact or omit to state a materialfact necessary to make the statements made, in light of thecircumstances under which such statements were made, notmisleading with respect to the period covered by this report;     3. Based on my knowledge, the financial statements, andother financial information included in this report, fairlypresent in all material respects the financial condition,results of operations and cash flows of the Registrant as of,and for, the periods presented in this report;     4. The Registrant’s other certifying officer and I areresponsible for establishing and maintaining disclosure controlsand procedures (as defined in Exchange ActRules 13a-15(e)and 15d-15(e)) andinternal control over financial reporting (as defined inExchange ActRules 13a-15(f)and 15d-15(f)) for theRegistrant and have:          a. Designed such disclosure controls and procedures, or    caused such disclosure controls and procedures to be designed    under our supervision, to ensure that material information    relating to the Registrant, including its consolidated    subsidiaries, is made known to us by others within those    entities, particularly during the period in which this quarterly    report is being prepared;           b. Designed such internal control over financial reporting,    or caused such internal control over financial reporting to be    designed under our supervision, to provide reasonable assurance    regarding the reliability of financial reporting and the    preparation of financial statements for external purposes in    accordance with generally accepted accounting principles;           c. Evaluated the effectiveness of the Registrant’s    disclosure controls and procedures and presented in this report    our conclusions about the effectiveness of the disclosure    controls and procedures, as of the end of the period covered by    this report based on such evaluation; and           d. Disclosed in this report any change in the    Registrant’s internal control over financial reporting that    occurred during the Registrant’s most recent fiscal quarter    that has materially affected, or is reasonably likely to    materially affect, the Registrant’s internal control over    financial reporting; and     5. The Registrant’s other certifying officer and Ihave disclosed, based on our most recent evaluation of internalcontrol over financial reporting, to the Registrant’sauditors and the audit committee of Registrant’s Board ofDirectors (or persons performing the equivalent functions):          a. all significant deficiencies and material weaknesses in    the design or operation of internal control over financial    reporting which are reasonably likely to adversely affect the    Registrant’s ability to record, process, summarize and    report financial information; and           b. any fraud, whether or not material, that involves    management or other employees who have a significant role in the    Registrant’s internal control over financial reporting.     /s/ Steven A. Gould, M.D.       Steven A. Gould, M.D.     Chief Executive OfficerDate: August 11, 2006