employment
agreement


 


This EMPLOYMENT AGREEMENT
(“Agreement”) is made effective as of April 2, 2013, by and between ENTREMED, INC., a Delaware corporation
having its principal office at 9620 Medical Center Drive, Suite 300, Rockville, MD 20850 (the “Company”) and
KEN K. REN (the “Executive”).


 


FOR AND IN CONSIDERATION
of the mutual premises, agreements and covenants contained herein, the parties hereto, intending to be legally bound, do hereby
agree as follows:


 


		1.	Employment; Position and Duties.



 


Subject to the terms
hereof, the Company hereby agrees to employ Executive during the Term (as hereafter defined) to act as, and to exercise all of
the powers and functions of, its Chief Executive Officer, and to perform such acts and duties and to generally furnish such services
to the Company and its subsidiaries as is customary for a senior executive management person with a similar position in like companies.
Among other things, and subject to change at the discretion of the Board of Directors (the “Board”), the Executive
shall serve as the Company’s key strategist in the execution of the Company’s global and China drug development strategy.
The Executive will also lead the Company’s corporate and business development initiative, overall research and development
strategy, fund-raising, and be responsible for general direction and leadership. Executive shall report directly to the Executive
Chairman of the Board and the Board of Directors, and have such other powers, duties and responsibilities as the Board of Directors
shall from time to time reasonably prescribe. Executive hereby agrees to accept such employment and shall perform and discharge
faithfully, diligently, and to the best of his abilities such duties and responsibilities and shall devote sufficient working time
and efforts to the business and affairs of the Company and its subsidiaries.


 


		2.	Place of Employment.



 


While Executive is
employed by the Company during the Term, Executive shall conduct his duties and responsibilities hereunder from the executive office
located in Rockville, Maryland and from the Company’s office located in Beijing, China (except for routine and customary
business travel), or from such other location as approved by the Executive Chairman or Board of Directors.


 


		3.	Compensation



 


a.          Base
Salary. While the Company employs the Executive during the Term, the Company shall pay to Executive an annual base salary (“Base
Salary”) of no less than US$300,000, payable in accordance with the Company’s customary payroll policy for its
executives.


 


b.          Base
Salary Adjustments. Executive’s Base Salary shall be reviewed at least annually in accordance with the Company’s
customary practices for its executives. The Board or a committee thereof may make such adjustments, as it deems appropriate in
its sole discretion; provided, however, in no event shall the Company pay Executive a Base Salary of less than US$300,000,
unless the change to Executive’s Base Salary was applicable to the annual base salary of all senior executives of the Company
in substantially the same manner.




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c.          Incentive
Compensation. While the Company employs Executive during the Term, Executive’s annual incentive compensation (“Incentive
Compensation”) shall be targeted at 25% of base compensation, the exact amount of which shall be determined by the Board
or a committee thereof in its sole discretion. Executive shall be eligible for Incentive Compensation commencing at the start of
the Initial Term. Such bonus, if any, shall be paid within ninety (90) days following the last day of each fiscal year of the Company;
provided, however, that Executive shall not be entitled to any such bonus unless Executive is employed by the Company on the date
of payment of such bonus. 


 


d.          Certain
Other Benefits. Throughout the Term, Executive shall be entitled to participate in any and all employee benefit plans and arrangements
which are available to senior executive officers of the Company, including without limitation, group medical, disability and life
insurance plans, and the Company’s Directors and Officers (D&O) insurance policy. Executive shall also be afforded no
fewer than twenty-three (23) days paid time off (PTO) pursuant to policies fixed by the Company. 


 


e.          Expenses.
The Company shall pay or reimburse Executive for all reasonable and necessary business expenses actually paid or incurred by Executive
while Executive is employed by the Company during the Term, subject to reasonable documentation and in accordance with the Company’s
business expense reimbursement policy. 


 


		4.	Term.



 


The term of this Agreement
shall be the period commencing on April 2, 2013 and continuing for one year (the “Initial Term”); provided,
however, that the Term of this Agreement shall be extended automatically for successive one year periods (each one-year
extension a “Successor Term” and together with the Initial Term referred to herein as the “Term”)
unless written notice of nonextension is provided by either party to the other party at least sixty (60) days prior to the end
of the Initial Term or any Successor Term. In the event that this Agreement is not extended at the end of the Initial Term or any
Successor Term and thereby terminates, only paragraphs 6, 7, 8(d), 8(g), 8(h), 8(i) and 11 shall survive such termination, except
that Executive shall be entitled to receive compensation and benefits to the extent expressly provided herein or by the terms of
any of the Company’s compensation and benefit plans, programs or policies or as required by applicable law.


 


		5.	Stock Options.



 


In connection with
Executive’s acceptance of employment, the Company shall grant stock options to Executive covering such number of shares of
the Company’s common stock to be approved by the Board or a committee thereof. The per share exercise price of the stock
options shall be equal to the closing price of the Company’s stock on the date of grant in accordance with the vesting schedule
of stock options awarded to other executives or as approved by the Board, and such award shall be subject to the terms and conditions
of the Company’s form of non-qualified stock option award agreement. Other periodic stock and non-qualified stock option
grants to Executive, if any, while the Company employs Executive during the Term shall be determined by the Board or a committee
thereof in its discretion. In the event of a termination pursuant to paragraph 8(d) hereof or a resignation pursuant to paragraph
9 hereof, for which purposes sections 10(a) and 10(c) of this Agreement shall control, all vested options held by Executive on
the effective date of such termination or resignation shall be exercisable in accordance with the terms of such grants until the
later of the date set forth in such grant or twelve (12) months following Executive’s date of termination, but in no event
beyond the expiration date of the relevant option. Upon a change in control, as defined in the option agreement, all unvested options
shall vest and become exercisable immediately in accordance with the terms of the option agreement. All other unvested options
shall expire in accordance with the terms of such grants. Except as set forth herein, the terms of the stock option grants under
this paragraph 5 shall be otherwise in accordance with and subject to the terms of the Company’s 2011 Long Term Incentive
Plan or successor plan and such terms and conditions as the Board or a committee thereof may specify.


 




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		6.	Unauthorized Disclosure.



 


During the Term and
at all times thereafter, Executive shall not, without the written consent of the Company, or except as required by applicable law,
disclose to any person, other than a person to whom disclosure is reasonably necessary or appropriate in connection with the performance
by Executive of his duties as an executive officer of the Company, any material confidential information obtained by Executive
while in the employ of the Company with respect to the businesses of the Company or any of its subsidiaries, including but not
limited to, operations, pricing, contractual or personnel data, products, discoveries, improvements, trade secrets, license agreements,
marketing information, suppliers, dealers, principles, customers, or methods of distribution, or any other confidential information
the disclosure of which Executive knows, or in the exercise of reasonable care should know, will be damaging to the Company; provided,
however, that confidential information shall not include any information known generally to the public or to persons in the industry
of which the Company’s business is a part (in each case, other than as a result of unauthorized disclosure by Executive)
or any information otherwise considered by the Company not to be confidential.


 


		7.	Indemnification.



 


a.          The Company shall
defend, indemnify and hold harmless Executive if he is made a party, or threatened to be made a party, to any threatened, pending
or completed action, suit or proceeding, whether civil, criminal, administrative, or investigative (a “Proceeding”),
because he is or was an officer or director of the Company or any of its subsidiaries, affiliates, or successors, or because he
is or was serving in a fiduciary capacity with respect to employee benefit plans of the Company, whether or not the basis of such
Proceeding is alleged action in an official capacity or otherwise, against all Expenses incurred or suffered by him in connection
with such Proceeding to the fullest extent authorized by the General Corporation Law of the State of Delaware and any other applicable
law in effect from time to time, and such indemnification shall continue as to Executive even if he ceases to be an officer or
director or is no longer employed by the Company, and shall inure to the benefit of Executive’s heirs, executors and administrators.


 


b.          As used in this
Agreement, the term “Expenses” shall include, without limitation, damages, losses, judgments, liabilities, fines, penalties,
excise taxes, settlements and reasonable costs, reasonable attorneys’ fees, reasonable accountants’ fees, and reasonable
disbursements and costs of attachment or similar bonds, investigations, and any reasonable expenses of establishing a right to
indemnification under this Agreement.


 


c.          Expenses incurred
by Executive in connection with any Proceeding shall be paid by the Company upon presentation of appropriate documentation and
a giving by Executive of any undertakings required by applicable law.


 




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		8.	Termination.



 


a.          Upon Death.
If Executive dies while employed by the Company during the Term, his estate shall be entitled to receive a lump sum payment equal
to the amount of Base Salary that would have been payable had Executive remained employed through the last day of the six (6) months
following the month in which death occurred, provided, however,  that if Executive’s death occurs during the first
three (3) months of his employment, his estate shall be entitled to receive a lump sum payment equal to the amount of Base Salary
that would have been payable had Executive remained employed through the last day of the three (3) months following the month in
which death occurred. If, in respect of the fiscal year in which Executive dies the Board or a committee thereof determines in
its discretion that he would otherwise have been entitled to receive Incentive Compensation under subparagraph 3(c) by reason of
the operations of the Company during such fiscal year, Executive’s estate shall be entitled to receive a pro rata portion
of his Incentive Compensation for such fiscal year. Such pro rata portion shall equal the product of (x) the full amount of such
Incentive Compensation, and (y) a fraction, the numerator of which is the number of days in the fiscal year of Executive’s
death prior to the date of death, and the denominator of which is the total number of days in such fiscal year. All payments under
this Section 8(a) shall be made within sixty (60) days of Executive’s death.


 


b.          Termination
Upon Disability. The Company may terminate Executive’s employment hereunder during the Term at the end of any calendar
month in the event of his Disability by giving to Executive written notice of termination. In the event of any such termination
pursuant to this subparagraph 8(b), Executive shall be entitled to receive a lump sum payment equal to the amount of his Base Salary
that would have been payable had Executive remained employed through the last day of the six (6) months following the month in
which termination occurred, provided, however, that if such Disability termination occurs during the first three (3) months
of his employment, he shall be entitled to receive a lump sum payment equal to the amount of Base Salary that would have been payable
had Executive remained employed through the last day of the three (3) months following the month in which termination occurred
If in respect of the fiscal year in which Executive’s employment terminates pursuant to this subparagraph 8(b) the Board
or a committee thereof determines in its discretion that he would otherwise have been entitled to receive Incentive Compensation
under subparagraph 3(c) by reason of the operations of the Company during such fiscal year, Executive shall be entitled to receive
a pro rata portion of his Incentive Compensation for such year. Such pro rata portion shall equal the product of (x) the full amount
of such Incentive Compensation, and (y) a fraction, the numerator of which is the number of days in the fiscal year of Executive’s
termination on account of Disability prior to the date of termination, and the denominator of which is the total number of days
in such fiscal year. All payments under this Section 8(b) shall be made within sixty (60) days of Executive’s Disability
termination.


 


c.          Termination
for Cause. The Company may terminate Executive’s employment hereunder at any time during the Term for Cause by giving
to Executive written notice of termination that specifies the reasons for and date of termination, subject to the terms of sub-paragraph
10(a) hereunder. Upon any such termination for Cause under this subparagraph 8(c), the Company shall pay to Executive Base Salary
through the date of termination, including the benefits provided at paragraph 3(d), and the Company shall have no further obligations
under this Agreement.


 




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d.         Termination
Without Cause. The Company may terminate Executive’s employment with the Company at any time during the Term, for any
reason and without Cause, by giving him written notice thirty (30) days prior to the date of termination. Until the effective
date of any such termination, the Company shall continue to pay to Executive the full compensation specified in this Agreement,
including the benefits provided at paragraph 3(d). Following the date of termination, Executive shall make himself reasonably
available to members of the Board and other senior managers and officers of the Company to assist in the transition of responsibilities
and information to others and to facilitate the orderly conduct of business operations. Upon termination, the Company shall have
no other financial obligations to Executive under any compensation or benefit plan, program or policy and Executive’s participation
in the Company’s compensation and benefit plans, programs and policies shall cease as of the date of Executive’s termination
except as set forth herein or as expressly provided under the terms of any such plans, programs or policies, or as required by
applicable law. However, in addition to the above, if Executive is terminated by the Company (i) pursuant to this subparagraph
8(d) or (ii) upon the Company’s nonextension of the Term yin accordance with Section 4 (provided that Executive is then
willing and able to continue to provide services under terms and conditions substantially similar to those in this contract) and
for any reason other than Cause, death or Disability, the Company shall (A) pay Executive a lump sum payment equal to the
amount of his Base Salary that would have been payable had Executive remained employed through the last day of the six (6) months
following the month in which termination occurred; and (B) a lump sum payment in an amount equal to six (6) months of COBRA premiums
for the level of coverage that Executive had in effect as of immediately prior to his termination. If, in respect of the fiscal
year in which Executive’s employment terminates pursuant to this subparagraph 8(d), the Board or a committee thereof determines
in its discretion that he would otherwise have been entitled to receive Incentive Compensation under subparagraph 3(c) by reason
of the operations of the Company during such fiscal year, Executive shall be entitled to receive a pro rata portion of his Incentive
Compensation for such year. Such pro rata portion shall equal the product of (x) the full amount of such Incentive Compensation,
and (y) a fraction, the numerator of which is the number of days in the fiscal year of Executive’s termination without
Cause prior to the date of termination, and the denominator of which is the total number of days in such fiscal year. All payments
under this Section 8(d) shall be made within sixty (60) days of Executive’s termination of employment.


 


e.          Resignation
for Other than Good Reason. Executive may voluntarily terminate his employment with the Company during the Term for any reason
upon at least thirty (30) days prior written notice, which specifies the effective date of termination. Until the effective date
of such termination, the Company shall continue to pay him the full compensation specified in this Agreement, including the benefits
provided at paragraph 3(d), provided he continues to perform his duties during this period. Thereafter, the Company shall have
no further obligations to him under this Agreement. This subparagraph 8(e) shall not apply to Executive’s resignation for
Good Reason pursuant to paragraph 9 hereof.


 


f.          No Mitigation. The parties hereto acknowledge and agree that, in the
event Executive’s employment with the Company is terminated pursuant to this paragraph 8, he shall not be required to mitigate
his damages by affirmatively seeking other employment. Further, except as provided in subparagraph 8(d)(ii) above, the amount
of any payment or benefit provided for in this Agreement shall not be reduced by any compensation earned by him or benefit provided
to him as the result of employment by another employer or otherwise.


 




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g.          Non-Competition. For the
period of (i) twelve (12) months after resignation for other than for Good Reason, or (ii) six (6) months after termination of
employment with the Company for any other reason, Executive shall not, as an individual, principal, agent, employee, consultant
or otherwise, directly or indirectly, or with respect to any company or entity with which the Company has concluded partnership,
licensing, joint research and development or other similar business agreements during his employment with the Company, render any
services to any firm or company or any division or subsidiary of any firm or company, engaged in the development or commercialization
of compounds, analogs or derivatives of those compounds that (a) are of a similar type, that is, small molecules, (b) have more
than one mechanism of action and cellular pathway in common with; and (c) are within the same field (i.e. oncology
or inflammation) as, those being developed and or commercialized by the Company during the Term (“Competing Company”).
In addition, for an additional period of six (6) months after the six-month period set forth above and subject to Section 6 hereof,
Executive only may provide services to such a Competing Company if Executive does not work on, or furnish confidential information
regarding, any matter related to such compounds defined above. Moreover, for a period of twelve (12) months after the termination
of Executive’s employment with the Company, Executive shall not take any action, without the prior written consent of the
Company, to assist Executive’s successor employer or any other entity in recruiting or hiring any other employee who was
an employee of the Company during Executive’s employment. This prohibition includes (i) identifying to such successor employer
or its agents or such other entity, the person or persons who have special knowledge concerning the Company or its inventions,
processes, methods or confidential affairs, and (ii) commenting to Executive’s successor employer or its agents or such other
entity about the quantity or work, quality of work, special knowledge or personal characteristics of any person who is still employed
by the Company. Executive also agrees that he will not provide such information to a prospective employer or to an executive search
firm during interviews preceding possible employment.


 


h.          Non-Disparagement.
During the Term and thereafter, Executive shall not communicate negatively about or otherwise disparage the Company or its products
or each and any of the released parties described in subparagraph 8(i) in any way whatsoever except as may be required for truthful
sworn testimony or in connection with a legal or administrative proceeding, report, claim or dispute. The Company, acting in its
official capacity, shall not make any public false, disparaging or derogatory statements in connection with or concerning Executive’s
service to the Company except as may be required for truthful sworn testimony or in connection with a legal or administrative proceeding,
report, claim or dispute. After termination, in the event Executive materially breaches any of the conditions set forth herein
or in any other paragraph of this Agreement, the Company may discontinue the provision of any payment or benefits to him under
this Agreement, and in such event he shall forfeit his entitlement to any further termination payments or benefits under this Agreement.
After termination, in the event the Company materially breaches any of the conditions set forth herein or in any other paragraph
of this Agreement, the Executive may pursue any remedies available to him at law.


 


i.          Release.
In consideration of Executive’s receipt of severance benefits subject to and in accordance with subparagraphs 8(b) and (d)
and paragraph 9 of this Agreement, Executive agrees that, upon his first receipt and acceptance of any such benefits, he shall
have released and forever discharged the Company, its subsidiaries and affiliates, successors and assigns, predecessors and all
of their respective officers, directors, employees and agents and employee benefits plans from all claims, demands, liabilities
and causes of action arising out of facts or occurrences arising or occurring at any time up to and including the time of Executive’s
termination or resignation, whether known or unknown, and the parties hereto contemplate that this release shall be broadly construed.


 




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		9.	Resignation for Good Reason.



 


If Executive has Good Reason during the
Term, Executive may resign at any time during the Term by providing at least thirty (30) days prior written notice to the Company
that specifies the reason for, and the effective date of, his resignation. If Executive resigns during the Term for Good Reason,
such resignation shall be deemed a Termination without Cause under subparagraph 8(d) hereof and Executive shall receive the compensation
and benefits provided under subparagraph 8(d) hereof as if he had been terminated without Cause.


 


		10.	Definitions.



 


a.          “Cause”
shall mean Executive’s (i) habitual drunkenness or drug addiction, (ii) material failure to perform and discharge his duties
and responsibilities hereunder, (iii) misconduct that is materially and significantly injurious to the Company, (iv) conviction
of a felony involving the personal dishonesty of Executive or moral turpitude, (v) conviction of any crime or offense involving
the property of the Company or (vi) material breach of Executive’s obligations under this Agreement, provided, however,
with regard to Section 10(a)(ii) and 10(a)(vi) above, the parties exclude for this purpose an action not taken in bad faith that
is remedied by Executive promptly upon receipt of written notice thereof given to the Company.


 


b.          “Disability”
shall mean the Executive’s incapacity due to physical or mental illness which prevents the proper performance of Executive’s
duties as set forth herein or established pursuant hereto for ninety (90) days in any twelve (12) month period of the Term. A qualified
independent physician mutually selected by the Company and the Executive shall determine any questions as to the existence or extent
of illness or incapacity of Executive, upon which the Company and Executive cannot agree. The determination of such physician certified
in writing to the Company and to the Executive shall be final and conclusive for all purposes of this Agreement. For purposes of
the disability provisions of this Agreement, if the Executive is unable to act on his own behalf due to incapacity, any person
legally authorized to do so may act on the Executive’s behalf.


 


c.          “Good
Reason” shall mean the occurrence of any of the following events, without the consent of Executive, during the Term:
(A) the material diminution of Executive’s authorities, duties or responsibilities; (B) a material reduction by the Company
in Executive’s annual Base Salary as in effect on the date hereof or subsequently in effect hereunder, except as agreed to
by Executive, unless such change was applicable to all senior executives of the Company; (C) a material breach of this Agreement
by the Company; or (D) a material change in the geographic location at which the Executive must perform services under this Agreement
(for purposes of this agreement, a material change in geographic location shall mean requirement by the Company that Executive
conduct his duties and responsibilities from a permanent location more than fifty (50) miles from the place of employment, as defined
in paragraph 2 herein). In no event shall a termination be deemed to be for “Good Reason” unless (i) Executive provides
the Company with written notice of the condition constituting “Good Reason” within 30 days of the initial existence
of such condition, (ii) the Company is provided a period of at least 30 days to cure the condition (if cured, such condition shall
not constitute “Good Reason”), and (iii) Executive’s employment terminates not more than two years following
the initial existence of such condition.


 


		11.	Miscellaneous.



 


a.          Assignments
and Binding Effect. The respective rights and obligations of the parties under this Agreement shall be binding upon the parties
hereto and their heirs, executors, administrators, successors, and assigns, including, in the case of the Company, any other corporation
or entity with which the Company may be merged or otherwise combined and, in the case of Executive, his estate or other legal representatives.


 




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b.          No
Assignment of Benefits. Except as otherwise provided herein or by applicable law, no right or interest of the Executive under
this Agreement shall be assignable or transferable, in whole or in part, either directly or by the operation of law or otherwise,
including without limitation execution, levy, garnishment, attachment, pledge or in any manner; no attempted transfer thereof
shall be effective.


 


c.          Governing Law. This Agreement shall be
governed as to its validity, interpretation and effect by the laws of the State of Maryland, without reference to its conflict
of laws provisions.


 


d.          Severability.
In the event that any provision or portion of this Agreement shall be determined to be invalid, illegal, or unenforceable for any
reason, the remaining provisions and portions of this Agreement shall remain in full force and effect to the fullest extent permitted
by law. Such invalid, illegal or unenforceable provision(s) shall be deemed modified to the extent necessary to make it (them)
valid, legal, and enforceable.


 


e.          Withholding.
All amounts payable hereunder shall be paid net of any applicable withholding required under federal, state or local laws and any
additional withholding to which Executive has agreed.


 


f.          Entire Agreement;
Amendments. This Agreement constitutes the entire Agreement and understanding of the Company and Executive with respect to
the terms of Executive’s employment with the Company and supersedes all prior discussions, understandings and agreements
with respect thereto.


 


g.          Captions.
All captions and headings used herein are for convenient reference only and do not form part of this Agreement.


 


h.          Waiver.
No provision of this Agreement may be modified, waived or discharged unless such modification, waiver or discharge is agreed to
in writing and signed by the Executive and the Board or its delegate. The failure of the Company or the Executive to insist upon
strict compliance with the terms of this Agreement or the failure of the Company or the Executive to assert any right the Company
or the Executive may have hereunder shall not be deemed a waiver of such provision or right or any other provision of this Agreement.


 


i.          Notice.
Any notice or communication required or permitted under this Agreement shall be made in writing and shall be delivered by hand,
or mailed by registered or certified mail, return receipt requested, first call postage prepaid, addressed as follows:


 


If to Executive:


 


Ken K. Ren


c/o EntreMed,
Inc.


9620 Medical
Center Drive


Suite 300


Rockville,
Maryland 20850


 




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If to the Company:


 


EntreMed, Inc.


9620 Medical
Center Drive


Suite 300


Rockville,
Maryland 20850


Attn.: General
Counsel


 


j.          Counterparts.
This Agreement may be executed in counterparts, each of which shall constitute one and the same agreement.


 


		12.	Section 409A.



 


This Agreement is intended
to comply with the requirements of Section 409A of the Code (including the exceptions thereto), to the extent applicable, and the
Company shall administer and interpret this Agreement in accordance with such requirements.  If any provision contained in
the Agreement conflicts with the requirements of Section 409A of the Code (or the exemptions intended to apply under the Agreement),
the Agreement shall be deemed to be reformed to comply with the requirements of Section 409A of the Code (or the applicable
exemptions thereto). Notwithstanding anything to the contrary herein, for purposes of determining the Executive’s entitlement
to the payments under Section 8 hereof, (i) the Executive’s employment shall not be deemed to have terminated unless and
until the Executive incurs a “separation from service” as defined in Section 409A of the Code, and (ii) the term termination
of employment (or any similar term) shall mean the effective date of the Executive’s separation from service.  Reimbursement
of any expenses provided for in this Agreement shall be made in accordance with the Company’s policies (as applicable) with
respect thereto as in effect from time to time (but in no event later than the end of calendar year following the year such expenses
were incurred); provided, however, that in no event shall the amount of expenses eligible for reimbursement hereunder
during a calendar year affect the expenses eligible for reimbursement in any other taxable year and in no event shall the right
to reimbursement be subject to liquidation or exchange for another benefit. Notwithstanding anything to the contrary herein, if
a payment or benefit under this Agreement is due to a “separation from service” for purposes of the rules under Treas.
Reg. § 1.409A-3(i)(2) (payments to specified employees upon a separation from service) and the Executive is determined to
be a “specified employee” (as determined under Treas. Reg. § 1.409A-1(i) and related Company procedures), such
payment shall, to the extent necessary to comply with the requirements of Section 409A of the Code, be made on the later of (x)
the date specified by the foregoing provisions of this Agreement or (y) the date that is six (6) months after the date of the Executive’s
separation from service (or, if earlier, the date of the Executive’s death). Any installment payments that are delayed pursuant
to this Section 12 shall be accumulated and paid in a lump sum on the first day of the seventh month following the Executive’s
separation from service (or, if earlier, upon the Executive’s death) and the remaining installment payments shall begin on
such date in accordance with the schedule provided in this Agreement. The payments under Section 8 hereof are intended not to constitute
deferred compensation subject to Section 409A of the Code to the extent such payments are covered by (i) the “short-term
deferral exception” set forth in Treas. Reg. § 1.409A-1(b)(4), (ii) the “two times severance exception”
set forth in Treas. Reg. § 1.409A-1(b)(9)(iii), or (iii) the “limited payments exception” set forth in Treas.
Reg. § 1.409A-1(b)(9)(v)(D). The short-term deferral exception, the two times severance exception and the limited payments
exception shall be applied to such payments in order of payment in such manner as results in the maximum exclusion of such payments
from treatment as deferred compensation under Section 409A of the Code. Each payment hereunder shall be deemed to be a separate
payment for purposes of Section 409A of the Code.


 


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IN WITNESS WHEREOF,
the parties hereto have executed this Agreement this 19th day of April, effective as of April 2, 2013. 


 


	 	Executive
	 	 
	 	Ken K. Ren
	 	 
	 	EntreMed, Inc.
	 	 
	 	By:	 
	 	 	Name: Cynthia W. Hu
	 	 	Title:   Chief Operating Officer,
	 	 	            General Counsel and Secretary


  




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