Exhibit 31.1



AMPLIPHI
BIOSCIENCES CORPORATION

CERTIFICATION



I, Jeremy Curnock Cook, certify that:



|1. | I have reviewed this annual report on Form 10-K of AmpliPhi Biosciences Corporation;
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|2. | Based on my knowledge, this report does not contain any untrue statement of a material fact
    or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements
    were made, not misleading with respect to the period covered by this report;
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|3. | Based on my knowledge, the financial statements, and other financial information included
    in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the
    registrant as of, and for, the periods presented in this report;
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|4. | The registrant’s other certifying officers and I are responsible for establishing
    and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal
    control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:
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| | a) | designed such disclosure controls and procedures, or caused such disclosure controls and
    procedures to be designed under our supervision, to ensure that material information relating to the registrant, including
    its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which
    this report is being prepared;
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| | b) | designed such internal control over financial reporting, or caused such internal control
    over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of
    financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted
    accounting principles;
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| | c) | evaluated the effectiveness of the registrant’s disclosure controls and procedures
    and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the
    end of the period covered by this report based on such evaluation; and
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| | d) | disclosed in this report any change in the registrant’s internal control over financial
    reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter
    in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant’s
    internal control over financial reporting; and
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|5. | The registrant’s other certifying officer(s) and I have disclosed, based on our most
    recent evaluation of internal control over financial reporting, to the registrant’s auditors and the audit committee
    of the registrant’s board of directors (or persons performing the equivalent functions):
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| | a) | all significant deficiencies and material weaknesses in the design or operation of internal
    control over financial reporting which are reasonably likely to adversely affect the registrant’s ability to record,
    process, summarize and report financial information; and
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| | b) | any fraud, whether or not material, that involves management or other employees who have
    a significant role in the registrant’s internal control over financial reporting.
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Date:  April 15, 2015



| | /s/Jeremy Curnock Cook                                   
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| | Jeremy Curnock Cook                                      
| | Interim Chief Executive Officer and Chairman of the Board