[Federal Register Volume 70, Number 182 (Wednesday, September 21, 2005)]
[Notices]
[Pages 55399-55400]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 05-18786]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

Centers for Disease Control and Prevention

[30 Day-05-04OP]


Proposed Data Collections Submitted for Public Comment and 
Recommendations

    The Centers for Disease Control and Prevention (CDC) publishes a 
list of information collection requests under review by the Office of 
Management and Budget (OMB) in compliance with the Paperwork Reduction 
Act (44 U.S.C. Chapter 35). To request a copy of these requests, call 
the CDC Reports Clearance Officer at (404) 371-5983. Send written 
comments to CDC, Desk Officer, Human Resources and Housing Branch by 
fax to (202) 395-6974. Written comments should be received within 30 
days of this notice.

Proposed Project

    Delayed Symptoms Associated with the Convalescent Period of a 
Dengue Infection--New--National Center for Infectious Diseases (NCID), 
Centers for Disease Control and Prevention (CDC).

Background and Brief Description

    Dengue is a vector-borne febrile disease of the tropics transmitted 
most often by the mosquito Aedes aegypti. Symptoms of the acute disease 
include fever, headache, rash, retro-orbital pain, myalgias, 
arthralgias, vomiting, abdominal pain and hemorrhagic manifestations.
    A number of symptoms are mentioned in the medical literature as 
associated with the convalescent period after dengue infection, 
including depression, dementia, loss of sensation, paralysis of lower 
and upper extremities and larynx, epilepsy, tremors, manic psychosis, 
amnesia, loss of visual acuity, hair loss, and peeling of skin. The 
evidence for these findings has derived mainly from case series and 
case reports, but no analytic study has been conducted to define the 
timing, frequency, and severity of these symptoms, and quantity the 
magnitude of the association between dengue infection and each of these 
disorders.
    The objective of this study is to compare mental health disorders 
and other delayed complications associated with dengue infection and 
convalescence among study groups. The study will be conducted in Puerto 
Rico, where dengue is endemic, in collaboration with Dengue Branch of 
the Centers for Disease Control and Prevention. Laboratory positive 
confirmed cases of dengue, laboratory negative suspected dengue cases, 
and neighborhood controls will be prospectively enrolled in the study. 
Telephone interviews will be conducted and information will be 
collected prospectively regarding symptoms experienced during the first 
five months after the onset of symptoms of a dengue infections. There 
are no costs to the respondents other than their time. The estimated 
annualized burden is 426 hours.

                                     Estimated Total Annualized Burden Hours
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                                                                                   Number of      Average burden
                         Respondents                              Number of      responses per     per response
                                                                 respondents       respondent       (in hrs.)
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Screeners....................................................              810                2             1/60
Laboratory positive confirmed dengue.........................              200                2            20/60
Dengue negative control......................................              200                2            20/60
Neighborhood control.........................................              200                2            20/60
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[[Page 55400]]

Joan Karr,
Acting Reports Clearance Officer, Centers for Disease Control and 
Prevention.
[FR Doc. 05-18786 Filed 9-20-05; 8:45 am]
BILLING CODE 4163-18-P