EXHIBIT 10.35


                                   AMENDMENT NO. 1
                         MANUFACTURING AND SUPPLY AGREEMENT

      WITNESSETH, THIS AMENDMENT NO. 1 effective as of the date last written
below (the "Amendment") to the Manufacturing and Supply Agreement dated December
22, 1999 (the "Agreement"), by and between Filtertek and HemaSure. The terms of
the Agreement are hereby incorporated by reference into this Amendment. In the
event of any conflict between the terms of the Agreement and the terms of this
Amendment, then the terms of this Amendment shall control.

      WHEREAS, on or around April 7, 2000 the American Red Cross temporarily
suspended use of HemaSure's r\LS system, a component of which is defined as the
"Product" in the Agreement; and

      WHEREAS, HemaSure desires to reimburse Filtertek for certain costs
associated with the Agreement, and to receive certain Product purchase price
reductions due to the availability of manufacturing automation; in each case
without HemaSure admitting that it is under any obligation whatsoever to do so
and without HemaSure committing to any such future reimbursements; and

      WHEREAS, Filtertek is willing to accept such reimbursement from HemaSure
and agree to a price reduction on future purchases of Products under the
Agreement subject to all of the terms and conditions of the Agreement and this
Amendment.

      NOW THEREFORE, in consideration of these promises and the mutual agreement
herein, and for other good and valuable consideration, the receipt and
sufficiency of which is hereby acknowledged, the parties agree as follows:

1.    On or before September 29, 2000 HemaSure shall pay to Filtertek the amount
      of Five Hundred Twenty Five Thousand Dollars ($525,000) as a reimbursement
      for a portion of certain periodic and recurring costs incurred by
      Filtertek dining the period of April 7, 2000 through September 30, 2000
      (the "Reimbursement Payment").

2.    The Reimbursement Payment shall not be construed as an admission by
      HemaSure that HemaSure has breached any provision of the Agreement or that
      HemaSure has any liability or obligation of any kind to make such payment.
      Further, the Reimbursement Payment is made on a non-precedent basis and
      HemaSure shall not be obligated to make such payments in the future.

3.    After the effective date of this Amendment, due to the availability of
      manufacturing automation, Filtertek agrees to a price reduction in the
      Product Pricing set forth in Attachment B over the next 2,500,000 units
      purchased by HemaSure from Filtertek under the Agreement (the "Reduced
      Price Units"). After HemaSure has purchased from Filtertek all of the
      Reduced Price Units, then the quantity of the Reduced Price Units shall be
      credited to the





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      Actual Annual Purchases for the appropriate Agreement Year
      for the purposes of determining Product Pricing for future purchases in
      accordance with Attachment B of the Agreement. During the time period when
      HemaSure is purchasing the Reduced Price Units, the Start-Up Pricing
      defined on Attachment B shall not apply to such purchases.

4.    After September 30, 2000 the parties shall discuss in good faith the
      necessity for any future reimbursement payments and/or any further price
      reductions, but no party shall be obligated to effect any such payment or
      reductions.

      IN WITNESS WHEREOF,  the parties have executed this Amendment in duplicate
originals by their duly authorized representatives effective as of the date last
written below.

FILTERTEK INC.:                    HEMASURE INC.:



/s/ Ronald J. Kay                  /s/ James Murphy
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Ronald J. Kay                      James Murphy
President                          Sr. Vice President & Chief Financial Officer



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Date                                Date



                                  /s/ Peter Sutcliffe
                                  ------------------------------------
                                  Peter Sutcliffe
                                  Vice President & Chief Operating Officer



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                                   Date