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                                                                   EXHIBIT 10.11


                   AMENDMENTS TO QUINTILES TRANSNATIONAL CORP.
                            EQUITY COMPENSATION PLAN


1.       FEBRUARY 1, 1996 - AMENDMENT PERMITTING DELEGATION OF COMMITTEE'S
         POWERS

         Effective February 1, 1996, the Board of Directors of Quintiles
Transnational Corp. (the "Board") amended the Quintiles Transnational Corp.
Equity Compensation Plan (the "Plan") as follows:

                  Section 3.1 shall be amended by deleting the third sentence in
         its entirety and inserting in lieu thereof the following two sentences:

                  The Committee, in its discretion, may delegate to one or more
                  of its members, or to one or more officers of the Corporation,
                  all or part of the Committee's authority and duties with
                  respect to grants and awards to individuals who are not
                  subject to the reporting and other provisions of Section 16 of
                  the Act; provided, however, that such persons must exercise
                  any authority so delegated to them within any guidelines
                  established by the Committee. The Committee may revoke or
                  amend the terms of a delegation at any time but such action
                  shall not invalidate any prior actions of the Committee's
                  delegate or delegates that were consistent with the terms of
                  the Plan.


2.       OCTOBER 24, 1996 - AMENDMENT ALLOWING COMMITTEE TO SET TIMES AND
         CONDITIONS UPON WHICH A NONQUALIFIED STOCK OPTION WILL TERMINATE UPON
         TERMINATION OF EMPLOYMENT

         Effective October 24, 1996, the Board amended the Plan as follows:

                  Article V shall be amended by deleting Section 5.3 in its
         entirety and inserting in lieu thereof a new Section 5.3 substantially
         in the form that follows:

         5.3      The times and conditions upon which a Nonqualified Stock
                  Option and its related Stock Right, if any, will terminate
                  where a Participant to whom such an option and related right
                  has been granted under the Plan terminates, or the Corporation
                  terminates, his or her employment, consultant, or service
                  relationship with the Corporation shall be determined by the
                  Committee when the option and related right are granted;
                  provided, however, that in no event 


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                  shall an option or related right be exercisable more than ten
                  (10) years from the date it was granted. Nothing in the Plan
                  or in any option or related right granted pursuant to the Plan
                  shall (a) confer on any individual any right to continue in
                  the employ of the Corporation or to continue any consultant or
                  service relationship with the Corporation or (b) interfere in
                  any way with the Corporation's right to terminate such
                  individual's employment, consultant or service relationship at
                  any time.

3.       JANUARY 1, 1998 - AMENDMENT DELETING ARTICLE REGARDING NONDISCRETIONARY
         AWARDS

         Effective January 1, 1998, the Board amended the Plan in response to
changes in securities rules that made it unnecessary to make formula awards of
stock options to outside directors in order to avoid potential short-swing
liability associated with such awards. The amendment deleted Article IX of the
Plan, which provided for formula awards, in its entirety.