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                                                                   EXHIBIT 10.05


                   AMENDMENT TO EXECUTIVE EMPLOYMENT AGREEMENT


         This Amendment to Executive Employment Agreement ("Amendment") is made
and entered into this the 25th day of October, 1999, by and between QUINTILES
TRANSNATIONAL CORP., a North Carolina Corporation (hereinafter the "Company"),
and RACHEL R. SELISKER (hereinafter the "Executive").

         WHEREAS, the Company and Executive are parties to an Executive
Employment Agreement dated January 1, 1995 (the "Employment Agreement"), a copy
of which is attached hereto as Exhibit A and incorporated herein; and

         WHEREAS, the Company and Executive desire to amend the Employment
Agreement;

         NOW, THEREFORE, in consideration of the mutual agreements set forth
herein, the legal sufficiency and adequacy of which are hereby acknowledged, the
parties agree to amend the Employment Agreement as follows:


         1.       The Employment Agreement is amended by adding the following
section:

13.      CHANGE IN CONTROL.

         13.1 For purposes of this Amendment, a "Change in Control" shall mean
the occurrence of any one of the following:

                  (A) An acquisition (other than directly from the Company) of
any voting securities of the Company by any "Person" (as such term is used in
Sections 3(A)(9), 13(D)(3) and 14(D)(2) of the Securities Exchange Act of 1934,
as amended (the "Act")), after which such Person, together with its "affiliates"
and "associates" (as such terms are defined in Rule 12b-2 under the Act),
becomes the "beneficial owner" (as such term is defined in Rule 13d-3 under the
Act), directly or indirectly, of more than one-third (33.33%) of the total
voting power of the Company's then outstanding voting securities, but excluding
any such acquisition by the Company, any Person of which a majority of its
voting power or its voting equity securities or equity interests is owned,
directly or indirectly, by the Company (for purposes hereof, a "Subsidiary"),
any employee benefit plan of the Company or any of its Subsidiaries (including
any Person acting as trustee or other fiduciary for any such plan), or Dennis B.
Gillings;


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                  (B) The shareholders of the Company approve a merger, share
exchange, consolidation or reorganization involving the Company and any other
corporation or other entity that is not controlled by the Company, as a result
of which less than two-thirds (66.66%) of the total voting power of the
outstanding voting securities of the Company or of the successor corporation or
entity after such transaction are held in the aggregate by the holders of the
Company's voting securities immediately prior to such transaction;

                  (C) The shareholders of the Company approve a liquidation or
dissolution of the Company, or approve the sale or other disposition by the
Company of all or substantially all of the Company's assets to any Person (other
than a transfer to a Subsidiary of the Company);

                  (D) During any period of twenty-four (24) consecutive months,
the individuals who constitute the Board of Directors of the Company at the
beginning of such period (the "Incumbent Directors") cease for any reason to
constitute at least two-thirds (66.66%) of the Board of Directors; provided,
however, that a director who is not a director at the beginning of such period
shall be deemed to be an Incumbent Director if such director is elected or
recommended for election by at least two-thirds (66.66%) of the directors who
are then Incumbent Directors.

         13.2 TERMINATION FOLLOWING CHANGE IN CONTROL. After the occurrence of a
Change in Control, Executive shall be entitled to receive payments and benefits
pursuant to this Amendment if, at the time of the Change in Control, (i)
Executive is in ECP Levels 1 to 2 and her employment is terminated pursuant to
Sections 13.2(A), (B), or (C) below, or (ii) Executive is in ECP Levels 2.5 to 4
and her employment is terminated pursuant to Sections 13.2(B) or (C) below.

                  (A) Within eighteen (18) months following a Change in Control,
Executive terminates her employment with Company by giving written notice of
such termination to Company.

                  (B) Within eighteen (18) months following a Change in Control,
Company terminates Executive's employment for reasons other than "Cause" as such
term is defined in Section 5 of the Employment Agreement.


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                  (C) Within eighteen (18) months following a Change in Control,
Executive terminates her employment with the Company for "Good Reason." For
purposes of this Amendment, "Good Reason" shall mean the occurrence after a
Change in Control of any of the following events or conditions:

                           (i) a change in Executive's status, title, position
or responsibilities (including reporting responsibilities) which, in Executive's
reasonable judgment, represents an adverse change from her status, title,
position or responsibilities in effect immediately prior thereto; the assignment
to Executive of any duties or responsibilities which in Executive's reasonable
judgment, are inconsistent with her status, title, position or responsibilities;
or any removal of Executive from or failure to reappoint or reelect her to any
of such positions, status, or title except in connection with the termination of
her employment for Cause or by Executive other than for Good Reason,

                           (ii) a reduction in Executive's base salary;

                           (iii) the Company's requiring Executive to be based
at any place outside a thirty (30) mile radius from Executive's principal place
of residence, except for reasonably required travel on Company's business which
is not greater than such travel requirements prior to the Change in Control;

                           (iv) the failure by the Company to continue in effect
any compensation, welfare or benefit plan in which Executive is participating at
the time of a Change in Control, including benefits pursuant to the Executive
Compensation Plan or similar plans, without substituting plans providing
Executive with substantially similar or greater benefits, or the taking of any
action by the Company which would adversely affect Executive's participation in
or materially reduce Executive's benefits under any such plans or deprive
Executive of any material fringe benefit enjoyed by Executive at the time of the
Change in Control;

                           (v) any purported termination of Executive's
employment for Cause without grounds therefor;

                           (vi) the insolvency or the filing (by any party
including the Company) of a petition for bankruptcy of the Company;


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                           (vii) any material breach by the Company of any
provision of the Employment Agreement after Executive has given the Company
notice of the material breach and at least thirty (30) days to cure the breach
(or such longer period as may be reasonably required to cure the breach as long
as the Company is making good faith efforts to do so.); or

                           (viii) the  failure of the Company to obtain an
agreement, satisfactory to Executive, from any successor or assign of the
Company to assume and agree to perform the Employment Agreement, including this
Amendment.

         13.3 SEVERANCE PAY AND BENEFITS. If Executive's employment with the
Company terminates under circumstances as described in Section 13.2. above,
Executive shall be entitled to receive all of the following:

                  (A) all accrued compensation through the termination date,
plus any Bonus for which the Executive otherwise would be eligible in the year
of termination, prorated through the termination date, payable in cash. For
purposes of Sections 13.3(A) and 13.3(B), "Bonus" shall be defined as any
benefits for which Executive would be eligible under the Executive Compensation
Plan. The amount of such Bonus shall be paid in cash and, for purposes of
Sections 13.3(A) and 13.3(B), shall be calculated as if Executive had achieved
100% of Executive's performance goals for that year.

                  (B) a severance payment equal to two and nine-tenths (2.9)
times the amount of Executive's most recent annual compensation, including the
amount of her most recent annual Bonus. The severance amount shall be paid (i)
in cash in thirty-four (34) equal monthly installments commencing one month
after the termination date; or (ii) in a lump sum, within one month after the
termination date, at the sole option of the Executive.

                  (C) the Company shall maintain in full force and effect, for
eighteen (18) months after the termination date, all life insurance, health,
accidental death and dismemberment, disability plans and other benefit programs
in which Executive is entitled to participate immediately prior to the
termination date, provided that Executive's continued participation is possible
under the general terms and provisions of such plans and programs. Executive's
continued participation in such plans and programs shall be at no greater cost
to Executive than the cost she bore for such participation immediately


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prior to the termination date. If Executive's participation in any such plan or
program is barred, Company shall arrange upon comparable terms, and at no
greater cost to Executive than the cost she bore for such plans and programs
prior to the termination date, to provide Executive with benefits substantially
similar to, or greater than, those which she is entitled to receive under any
such plan or program; and

                  (D) a lump sum payment (or otherwise as specified by Executive
to the extent permitted by the applicable plan) of any and all amounts
contributed to a Company pension or retirement plan which Executive is entitled
to under the terms of any such plan through the date of termination.

         13.4 STOCK OPTIONS.

                  (A) Upon a Change in Control, all options ("Options") to
purchase Common Stock of the Company held by Executive as of the date of the
Change in Control shall become fully vested and exercisable.

                  (B) If Executive's employment with the Company terminates
pursuant to Section 13.2, then the Options shall remain exercisable until the
later of:

                           (i) the expiration of the applicable period for
exercise following termination of employment set forth in the Option agreements
(or in any other agreement between Executive and the Company that supersedes the
Option agreements); or

                           (ii) three (3) years after the date of termination
(to the extent of the terms of the Options); provided, however, that any
"incentive stock options" within the meaning of Section 422 of the Internal
Revenue Code of 1986, as amended (the "Code"), that are exercised more than
ninety (90) days after the date of termination pursuant Section 13.2 shall be
treated for tax purposes as nonqualified stock options.

          13.5  EXCISE TAX PAYMENTS.

                  (A) If any payment or benefit (within the meaning of Section
280G(b)(2) of the Code), to Executive or for her benefit pursuant to this
Agreement (a "Payment") is subject to the excise tax imposed by Section 4999 of
the Code (the "Excise Tax"), then the amount of the Payment net of all taxes
other than the Excise Tax (the


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"Net Amount") shall be calculated. Executive shall then receive, in addition to
the Payment, an additional payment (the "Gross-Up Payment"), which shall be an
amount such that, after payment of all taxes (including the Excise Tax) on the
Payment and the Gross-Up Payment, Executive shall retain an amount equal to the
Net Amount.

                  (B) An initial determination as to whether a Gross-Up Payment
is required pursuant to this Amendment and the amount of such Gross-Up Payment
shall be made at Company's expense by an accounting firm selected by Company and
reasonably acceptable to Executive which is designated as one of the five
largest accounting firms in the United States (the "Accounting Firm"). The
Accounting Firm shall provide its determination (the "Determination"), together
with detailed supporting calculations and documentation to Company and Executive
within ten (10) days of the date Executive's employment terminates if
applicable, or such other time as requested by Company or by Executive (provided
Executive reasonably believes that any of the Payments may be subject to the
Excise Tax) and if the Accounting Firm determines that no Excise Tax is payable
by Executive with respect to a Payment, it shall furnish Executive with an
opinion reasonably acceptable to Executive that no Excise Tax will be imposed
with respect to any such Payment. Within ten (10) days of the delivery of the
Determination to Executive, Executive shall have the right to dispute the
Determination (the "Dispute"). The Gross-Up Payment, if any, as determined
pursuant to this Section 13.5 shall be paid by Company to Executive within five
(5) days of the receipt of the Accounting Firm's determination. The existence of
the Dispute shall not in any way affect Executive's right to receive the
Gross-Up Payment in accordance with the Determination. Upon the final resolution
of a Dispute, Company shall promptly pay to Executive any additional amount
required by such resolution. If there is no Dispute, the Determination shall be
binding, final and conclusive upon Company and Executive subject to the
application of Section (C) below.

                  (C) Notwithstanding anything in this Amendment to the
contrary, in the event that, according to the Determination, an Excise Tax will
be imposed on any Payment, Company shall pay to the applicable government taxing
authorities as Excise Tax withholding, the amount of the Excise Tax that the
Company has actually withheld from the Payment and the Gross-Up Payment, as
applicable.

                  (D) If Executive is subject to taxation under a non-United
States taxing authority and an excise tax similar to the Excise Tax is imposed
on any Payment by such non-United States taxing authority, then Executive shall
be entitled to


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receive a Gross-Up Payment as calculated pursuant to Section 13.5(A) above,
based upon the lesser of such non-United States excise tax imposed and the
Excise Tax that would have been imposed had the Payment been subject to United
States taxation.

         2. Except as herein set forth, the Employment Agreement is not modified
or amended and the parties hereto reaffirm and agree to all of the terms and
provisions of the Employment Agreement, as herein amended, in all respects.

         IN WITNESS WHEREOF, the parties have executed this Amendment to
Executive Employment Agreement as of the day and year first written above.

                                         QUINTILES TRANSNATIONAL CORP.



                                         By:    /s/ Dennis B. Gillings
                                                --------------------------------
                                         Name:  Dennis Gillings
                                         Title: Chairman and CEO



                                                /s/ Rachel R. Selisker
                                         ---------------------------------------
                                                  RACHEL R. SELISKER



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