Sublease, dated June 1, 2002



  
 Exhibit 10.40

 SUBLEASE 
 THIS SUBLEASE (“Sublease”), dated June 1, 2002 (the “Commencement Date”), is entered into by and between DIADEXUS,
INC., a Delaware corporation (“Sublandlord”), and VIROLOGIC, INC. a Delaware corporation (“Subtenant”). 
 RECITALS 
 A.    Sublandlord, as
successor-in-interest to Subtenant pursuant to an Assignment and Assumption of Lease of even date herewith, leases certain premises (the “Premises”) consisting of approximately 53,980 square feet in a building, located at 343 Oyster Point
Boulevard, South San Francisco, California, pursuant to that certain Lease dated November 23, 1999, between ARE-Technology Center SSF, LLC, a Delaware limited liability company, successor-in-interest to Trammell Crow Northern California
Development, Inc., as landlord (the “Master Landlord”), and Sublandlord, as tenant, as amended by (i) that certain First Amendment to Lease Agreement dated February     , 2000 and (ii) that certain
Consent to Assignment and Modification of Lease of even date herewith (collectively, the “Master Lease”). The Premises is more particularly described in the Master Lease, a copy of which is attached hereto as Exhibit A. Capitalized
terms used but not defined herein have the same meanings as they have in the Master Lease. 

B.    Sublandlord desires to sublease to Subtenant a portion of the Premises comprising
approximately 13,630 square feet and depicted on Exhibit B attached hereto (the “Sublease Premises”), and Subtenant desires to sublease the Sublease Premises from Sublandlord on the terms and provisions hereof. 

Now, THEREFORE, in consideration of the mutual covenants and conditions contained herein,
Sublandlord and Subtenant covenant and agree as follows: 
 AGREEMENT 

1.    Sublease Premises. On and subject to the terms and conditions below, Sublandlord hereby leases to
Subtenant, and Subtenant hereby leases from Sublandlord, the Sublease Premises. 
 2.    Term.

 (a)    This Sublease shall commence upon the Commencement Date,
provided Sublandlord and Subtenant have theretofore obtained the Consent to Assignment and Modification of Lease (the “Consent”) signed by the Master Landlord in the form of Exhibit C attached hereto, and shall expire
on September 30, 2003, unless sooner terminated pursuant to any provision hereof. 

(b)    Subtenant shall have an option to extend the term hereof to December 31, 2003
(i.e., for a period of three (3) months); provided that Subtenant delivers notice of such exercise to Sublandlord on or before January 1, 2003 and provided, further, that Subtenant is not in default under this Sublease at the time of
exercise or at the commencement of the extension period. 







  

3.    Possession. Subtenant acknowledges that it is in possession of the
Sublease Premises on the Commencement Date. 
 4.    Rent. 

(a)    Commencing on the Commencement Date and continuing throughout the term of this
Sublease, Subtenant shall pay monthly rent (“Rent”) to Sublandlord in the following amounts: 

(i)    Base Rent. Subtenant shall pay to Sublandlord monthly base rent (“Base
Rent”) in an amount equal to a pro-rata portion of the base rent payable by Sublandlord under the Master Lease based on the square footage of the Sublease Premises in proportion to the square footage of the entire Premises, as follows:

  

							
	 June 2002:
	  	$	28,350.00	  	  	($2.08/square foot)
	 July 2002-June 2003:
	  	$	29,168.00	  	  	($2.14/square foot)
	 July 2003-October 2003
	  	$	30,122.00	  	  	($2.21/square foot)

 If,
pursuant to Section 2(b) above, the term of this Sublease is extended to December 31, 2003, Base Rent during such extended term shall be the same as set forth above for the months July, 2003 through October, 2003. 

(ii)    Additional Rent. In addition to Base Rent, Subtenant also shall pay to
Sublandlord, (a) Subtenant’s proportionate share of Tenant’s Proportionate Share of Basic Operating Costs (as such terms are defined in the Basic Lease Information and in Section 7 of the Master Lease), (b) all other costs
payable by Sublandlord with respect to the Sublease Premises under the Master Lease, except penalties, interest and other costs and fees arising from a default by Sublandlord under the Master Lease, and (c) any costs and expenses applicable to
the Sublease Premises which are paid directly by Sublandlord, if any, including, but not limited to, utilities, personal property taxes and real property taxes (collectively, “Additional Rent”). Subtenant shall pay Subtenant’s share
of Basic Operating Costs and any Rent Increase as and when such payments are due from Sublandlord pursuant to the Master Lease, but at least five (5) business days prior to the date Sublandlord must pay such amounts to Master Landlord. Within
ten (10) days of receipt by Sublandlord from Master Landlord, Sublandlord shall provide to Subtenant copies of all notices relating to Estimated Basic Operating Costs and Basic Operating Cost Adjustments applicable to the Sublease Premises.
Subtenant shall pay items of Additional Rent other than Basic Operating costs within ten (10) days after receipt of written demand from Sublandlord, which demand shall be accompanied by any invoice or statement that Sublandlord received from
Master Landlord relating thereto. Promptly upon receipt from Master Landlord, Sublandlord shall provide Subtenant with an estimate of Additional Rent for the year 2003, together with any notices received by Sublandlord from Master Landlord with
respect thereto. 
 (iii)    Payment of Rent. If the termination or
expiration date of this Sublease does not fall on the last day of a calendar month, Rent for such month shall be prorated on a daily basis based upon a calendar month. Rent shall be payable to Sublandlord in lawful money of the United States, in
advance, without prior notice, demand, or offset, at least five (5) business days prior to the first day of each calendar month during the term hereof. All Rent shall be paid to Sublandlord at the address specified for notices to Sublandlord in
Section 13 below. 

  
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(b)    In the event of any casualty or condemnation affecting the Sublease Premises, Rent payable by
Subtenant shall be abated hereunder, but only to the extent that Rent under the Master Lease is abated, and Subtenant waives any right to terminate this Sublease in connection with such casualty or condemnation except to the extent the Master Lease
is also terminated as to the Sublease Premises or any portion thereof. 
 (c)    Base Rent
and Additional Rent may be referred to herein collectively as “Rent.” 

5.    Security Deposit. On or prior to the Commencement Date, Subtenant shall deliver
to Sublandlord the sum of Fifty Six Thousand Seven Hundred Dollars and No/100 Dollars ($56, 700.00) as security for the performance of Subtenant’s obligations under this Sublease (“Security Deposit”). If Subtenant fails to pay Rent or
other charges when due under this Sublease, or fails to perform any of its other obligations hereunder, Sublandlord may use or apply the portion of the Security Deposit required for the payment of any Rent or other amount then due hereunder and
unpaid, for the payment of any other sum for which Sublandlord may become obligated by reason of Subtenant’s default or breach, or for any loss or damage sustained by Sublandlord as a result of Subtenant’s default or breach. If Sublandlord
so uses any portion of the Security Deposit, Subtenant shall restore the Security Deposit to the full amount originally deposited within ten (10) days after receipt of Sublandlord’s written demand therefor. Sublandlord shall not be
required to keep the Security Deposit separate from its general accounts, and shall have no obligation or liability for payment of interest on the Security Deposit. The Security Deposit, or so much thereof as had not theretofore been applied by
Sublandlord, shall be returned to Subtenant within thirty (30) days of the expiration or earlier termination of this Sublease, provided Subtenant has vacated the Sublease Premises in accordance with the terms of this Sublease. 

In lieu of a cash Security Deposit, Subtenant may provide to Sublandlord an unconditional, irrevocable letter of credit
(“Letter of Credit”) in the amount set forth in this Section 5 in favor of Sublandlord and issued by a bank located in the Bay Area and reasonably acceptable to Sublandlord (“Issuer”). The Letter of Credit shall be in form
reasonably acceptable to Sublandlord. The Letter of Credit shall provide that draws, including partial draws, at Sublandlord’s election, will be honored upon the delivery to the Issuer of notice signed by Sublandlord, or its authorized agent,
that an event of default has occurred under the Sublease. Any draw or partial draw of the Letter of Credit shall not constitute a waiver by Sublandlord of its right to enforce its other remedies hereunder, at law or in equity. If any portion of the
Letter of Credit is drawn upon, Subtenant shall, within ten (10) days after delivery of written demand from Sublandlord, restore said Letter of Credit to its original amount. The Letter of Credit shall be for the term of one year and
automatically shall be renewed each year for the term of sixty (60) days beyond the termination or earlier expiration of the Sublease. The Letter of Credit will automatically renew each year during the Sublease term unless the beneficiary under
the Letter of Credit is given at least thirty (30) days prior notice of a non-renewal by the issuing bank, and Sublandlord shall be able to draw on the Letter of Credit in the event of such notice. 

6.     Assignment and Subletting. Subtenant may not assign, sublet, transfer, pledge,
hypothecate or otherwise encumber the Sublease Premises, in whole or in part, or permit the use or occupancy of the Sublease Premises by anyone other than Subtenant, unless Subtenant has obtained Sublandlord’s consent thereto, which consent
shall not be unreasonably withheld, and the consent of Master Landlord in accordance with the terms of the Master Lease; provided, however, that no such consent shall be required upon Subtenant’s assignment or subletting of the Sublease
Premises to a Permitted Assignee (as such term is defined in Section 21 of the Master Lease). Regardless of Sublandlord’s consent, no subletting or assignment shall release Subtenant of its obligations hereunder. Any rent or other
consideration payable to Subtenant pursuant to any sublease or assignment permitted by this paragraph which is in excess of the Rent payable by Subtenant to Sublandlord pursuant hereto (“Bonus Rent”) shall be paid to Sublandlord. In
calculating Bonus Rent, Subtenant may first deduct from the rent or other consideration received (a) the amortization of a reasonable brokerage commission, and (b) the amortization of the cost of tenant improvements, if any, paid for by
Subtenant in connection with the assignment or subletting. 

  
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7.    Condition of Sublease Premises. Subtenant has used due diligence in inspecting the
Sublease Premises and is satisfied with the condition of the Sublease Premises and the property, including the environmental condition thereof. Subtenant agrees to accept the Sublease Premises in “as-is” condition and with all faults
without any representation or warranty of any kind or nature whatsoever, and without any obligation on the part of Sublandlord to modify, improve or otherwise prepare the Sublease Premises for Subtenant’s occupancy. 

8.    Use. Subtenant may use the Sublease Premises only for the purposes allowed in the Master
Lease and for no other purpose. Subtenant shall promptly comply with all applicable statutes, ordinances, rules, regulations, orders, and restrictions of record in effect during the term of this Sublease governing, affecting and regulating the
Sublease Premises, including but not limited to the use thereof. Subtenant shall not use or permit the use of the Sublease Premises in a manner that will create waste or a nuisance, interfere with or disturb other tenants in the Building or violate
the provisions of the Master Lease. 
 9.    Parking. Subtenant shall have a
proportional interest in such parking rights as Sublandlord has in connection with the Sublease Premises pursuant to the Master Lease. 
 10.    Incorporation of Sublease. 

(a)    All of the terms and provisions of the Master Lease, except as provided in subsection
(b) below, are incorporated into and made a part of this Sublease and the rights and obligations of the parties under the Master Lease are hereby imposed upon the parties hereto with respect to the Sublease Premises, Sublandlord being
substituted for the “Landlord” in the Master Lease, and Subtenant being substituted for the “Tenant” in the Master Lease. It is further understood that where reference is made in the Master Lease to the “Premises,” the
same shall mean the Sublease Premises as defined herein; where reference is made to the “Term Commencement Date,” the same shall mean the Commencement Date as defined herein; and where reference is made to the “Lease,” the same
shall mean this Sublease. Notwithstanding the foregoing, the term “Landlord” in the following sections of the Master Lease (i) shall mean Master Landlord, not Sublandlord: 8.A., 10, 24, 28, 36.J, 37.F and (ii) shall mean both
Master Landlord and Sublandlord: 18. 
 (b)    The following paragraphs of the Master
Lease are not incorporated herein: Basic Lease Information (except definitions that are applicable to and appropriate in the context of this Sublease), 1, 2, 3, 6,19, 20, 21.B., 31, 35, 37.C, D, E, G and H, Exhibit A-2, Exhibit B-l, Exhibit B-3,
Exhibit C, Exhibit F, and Exhibit Q. 

  
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(c)    Subtenant hereby assumes and agrees to perform for Sublandlord’s benefit, during
the term of this Sublease, all of Sublandlord’s obligations with respect to the Sublease Premises under the Master Lease, except as otherwise provided herein. Subtenant shall not commit or permit to be committed any act or omission which
violates any term or condition of the Master Lease. Except as otherwise provided herein, this Sublease shall be subject and subordinate to all of the terms of the Master Lease. 

(d)    Except as expressly set forth herein, Sublandlord hereby grants to Subtenant all of the
rights, privileges and benefits granted to or conferred upon Sublandlord as tenant under the Master Lease, provided that Subtenant’s exercise of such rights, privileges and benefits do not result in or cause Sublandlord to default under the
Master Lease. 
 11.    Insurance. Subtenant shall be responsible for compliance with
the insurance provisions of the Master Lease. Such insurance shall insure the performance by Subtenant of its indemnification obligations hereunder and shall name Master Landlord and Sublandlord as additional insureds. All insurance required under
this Sublease shall contain an endorsement requiring thirty (30) days written notice from the insurance company to Subtenant and Sublandlord before cancellation or change in the coverage, insureds or amount of any policy. Subtenant shall
provide Sublandlord with certificates of insurance evidencing such coverage prior to the commencement of this Sublease. 
 12.    Default. In addition to defaults contained in the Master Lease, failure of Subtenant to make any payment of Rent when due hereunder shall constitute an event of default
hereunder. If Subtenant’s default causes Sublandlord to default under the Master Lease, Subtenant shall defend, indemnify and hold Sublandlord harmless from all damages, costs (including reasonable attorneys’ fees), liability, expenses or
claims relating to such default. 
 13.    Notices. The addresses specified in the
Master Lease for receipt of notices to each of the parties are deleted and replaced with the following: 
  

			
	To Sublandlord at:	    	 diaDexus, Inc.
 343 Oyster
Point Boulevard
 South San Francisco, CA 94080
 Attn: Sharon Tetlow

		
	To Subtenant at:	    	 Virologic, Inc.
 345 Oyster
Point Boulevard
 South San Francisco, CA 94080
 Attn: Karen Wilson/Kathy Hibbs


 All notices hereunder shall be
in writing and shall be sent by (a) messenger or hand delivery; (b) reputable overnight air courier service; or (c) certified or registered U.S. Mail, postage prepaid, return receipt requested. Notice shall be deemed given on the
earlier of the date delivered or refusal of a party to accept delivery thereof. Each party immediately shall provide the other with a copy of any notice of default given to or received from Master Landlord with respect to this Sublease or the
Sublease Premises. 

  
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14.    Sublandlord’s Obligations. 

(a)    To the extent that the provision of any services or the performance of any maintenance
or any other act respecting the Sublease Premises or the building in which the Sublease Premises is located (the “Building”), including, without limitation, the performance and completion of Landlord’s Work (as defined in the Master
Lease), is the responsibility of Master Landlord (collectively “Master Landlord Obligations”), upon Subtenant’s written request, Sublandlord shall make reasonable efforts to cause Master Landlord to perform such Master Landlord
Obligations, including the commencement of appropriate legal proceedings; provided, however, that, except to the extent resulting from Sublandlord’s breach of or default under the Master Lease which is not the result of Subtenant’s
breach or default hereunder, in no event shall Sublandlord be liable to Subtenant for any liability, loss or damage whatsoever in the event that Master Landlord should fail to perform the same, nor shall Subtenant be entitled to withhold the payment
of Rent or to terminate this Sublease, except to the extent Sublandlord has such a termination right under the Master Lease. If Sublandlord is unsuccessful in obtaining the performance by Master Landlord of the Master Landlord Obligations in
accordance with the immediately preceding sentence, then Subtenant shall have the right, upon prior written notice to Sublandlord, to exercise in its own name all of the rights available to Sublandlord under the Master Lease to enforce performance
on the part of Master Landlord. It is expressly understood that the services and repairs which are incorporated herein by reference, including but not limited to the maintenance of exterior walls, structural portions of the roof, foundations, walls
and floors, will in fact be furnished by Master Landlord and not by Sublandlord, except to the extent otherwise provided in the Master Lease. In addition, Sublandlord shall not be liable for any maintenance, restoration (following casualty or
destruction) or repairs in or to the Building or Sublease Premises, other than its obligation hereunder to use reasonable efforts to cause Master Landlord to perform its obligations under the Master Lease. With respect to any maintenance or repair
to be performed by Master Landlord respecting the Sublease Premises, the parties expressly agree that Subtenant shall have the right to contact Master Landlord directly to cause it to so perform. 

(b)    So long as Subtenant complies with its obligations under this Sublease:
(i) Sublandlord shall not agree to any amendment of the Master Lease which materially affects Subtenant’s rights under this Sublease; (ii) Sublandlord shall not, without Subtenant’s written consent, exercise any right to
terminate the Master Lease with respect to any period during the Sublease term, other than on account of a default by Master Landlord under the Master Lease, casualty or condemnation; and (iii) Sublandlord shall perform all of its obligations
under the Master Lease not assumed by Subtenant hereunder, including, without limitation, the prompt payment to Master Landlord of all sums paid by Subtenant to Sublandlord hereunder. 

(c)    Sublandlord represents to Subtenant that (i) the Master Lease is in full force and
effect, (ii) Sublandlord is not in default under the Master Lease with respect to any obligation arising after the Commencement Date and, to Sublandlord’s knowledge, Master Landlord is not in default thereunder, (iii) the Master Lease
attached hereto is a full and complete copy of the Master Lease, and (iv) as of the Commencement Date, Sublandlord’s leasehold estate is not encumbered by any deed of trust or mortgage financing. 

  
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(d)    Subtenant represents to Sublandlord that, immediately prior to the Commencement Date,
(i) the Master Lease was in full force and effect, (ii) Subtenant was not in default under the Master Lease with respect to any obligation arising before the Commencement Date and, to Subtenant’s knowledge, Master Landlord was not in
default thereunder, (iii) the Master Lease attached hereto is a full and complete copy of the Master Lease, and (iv) Subtenant’s leasehold estate under the Master Lease was not encumbered by any deed of trust or mortgage financing.

 (e)    Except as otherwise provided herein, Sublandlord shall have no other
obligations to Subtenant with respect to the Sublease Premises or the performance of the Master Landlord Obligations. 
 15.    Early Termination of Sublease. If, without the fault of Sublandlord, the Master Lease should terminate prior to the expiration of this Sublease, Sublandlord shall have no
liability to Subtenant on account of such termination. Subject to Section 14(b) above, to the extent that the Master Lease grants Sublandlord any discretionary right to terminate the Master Lease, whether due to casualty, condemnation, or
otherwise, Sublandlord shall be entitled to exercise or not exercise such right in its complete and absolute discretion. 
 16.    Consent of Master Landlord and Sublandlord. If Subtenant desires to take any action which requires the consent or approval of Sublandlord pursuant to the terms of this
Sublease, prior to taking such action, including, without limitation, making any alterations, then, notwithstanding anything to the contrary herein, (a) Sublandlord shall have the same rights of approval or disapproval as Master Landlord has
under the Master Lease, and (b) Subtenant shall not take any such action until it obtains the consent of Sublandlord and Master Landlord, as may be required under this Sublease or the Master Lease. This Sublease shall not be effective unless
and until the Consent shall have been obtained. Each of Sublandlord and Subtenant represents and warrants to the other that it has obtained all necessary corporate approvals for the execution and delivery of this Sublease. 

17.    Indemnity. Subtenant shall indemnify, defend, protect, and hold Sublandlord and Master
Landlord harmless from and against all actions, claims, demands, costs, liabilities, losses, reasonable attorneys’ fees, damages, penalties, and expenses (collectively “Claims”) which may be brought or made against Sublandlord or
which Sublandlord may pay or incur to the extent caused by (i) a breach of this Sublease by Subtenant, (ii) any violation of law by Subtenant or its employees, agents, contractors or invitees (collectively, “Agents”) relating to
the use or occupancy of the Sublease Premises, (iii) any act or omission by Subtenant or its Agents resulting in contamination of any part or all of the Sublease Premises or the Building by Hazardous Materials or (iv) the negligence or
willful misconduct of Subtenant or its Agents. Sublandlord shall indemnify and hold Subtenant harmless from and against any and all loss, liability or expense, including reasonable attorneys’ fees, incurred or suffered by Subtenant on account
of (i) the Sublandlord’s material breach of this Sublease, (ii) a default by Sublandlord under the Master Lease to the extent not caused by Subtenant or (iii) Sublandlord’s gross negligence of willful misconduct with respect
to the Sublease Premises or this Sublease. 
 18.    Brokers. Each party hereto
represents and warrants that it has dealt with no brokers in connection with this Sublease and the transactions contemplated herein, except Mark Pearson of CRESA Partners (“Broker”). All Broker fees and commissions shall be paid by
Subtenant in accordance with the terms of a separate agreement between Subtenant and Broker. Each party shall indemnify, protect, defend and hold the other party harmless from all costs and expenses (including reasonable attorneys’ fees)
arising from or relating to a breach of the foregoing representation and warranty. 

  
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19.    Right of First Offer. 

(a)    So long as Virologic, Inc. (or a Permitted Assignee) is the Subtenant hereunder and
occupies the entirety of the Sublease Premises, and subject to the conditions set forth in this Section 19, prior to entering into a sublease proposal with a third party for all or any portion of the Premises (the “Offered Space”)
pursuant to which the third party would occupy such portion of the Premises during the term of this Sublease, Sublandlord shall deliver to Subtenant a written notice (the “ROF Notice”) informing Subtenant of Sublandlord’s intent to
sublease the Offered Space to a third party during the term of this Sublease. 

(b)    Within ten (10) days of receipt of the ROF Notice, Subtenant shall notify
Sublandlord in writing of Subtenant’s election to sublease the Offered Space (the “Acceptance Notice”). Failure of Subtenant to timely deliver the Acceptance Notice shall be deemed an election by Subtenant not to sublease the Offered
Space, and Subtenant shall have no further rights to sublease any portion of the Offered Space thereafter. Subtenant’s right of first offer set forth in this Section 19 is a one-time right. 

(c)    Immediately following receipt of the Acceptance Notice, Sublandlord and Subtenant shall
negotiate in good faith the terms of an amendment to this Sublease to incorporate the Offered Space. The parties shall use best efforts to finalize and execute such sublease within ten (10) days of Sublandlord’s receipt of the Acceptance
Notice. The amendment shall (i) add the Offered Space to the Sublease Space, (ii) set forth the economic terms applicable to the Offered Space, and (iii) provide that the term of the Offered Space is coterminous with the Sublease
Premises. Base Rent for the Offered Space shall be the “Fair Market Rent” for the Offered Space as agreed to by the parties. “Fair Market Rent” shall mean the then current market rent for comparable facilities in the proximate
South San Francisco market area. The definition of comparable facilities shall incorporate the parking amenities of the Premises and its use as an office/laboratory space, and the Building’s location, age, quality, amenities, identity, exterior
appearance, interior improvements, and type of construction. If the parties are unable to agree on Fair Market Rent within thirty (30) days of Sublandlord’s receipt of the Acceptance Notice, then Fair Market Rent shall be determined in
accordance with subsection (e) below. In no event, however, shall Base Rent for the Offered Space be less than the then current Base Rent for the Sublease Premises. 

(d)    Anything herein to the contrary notwithstanding, if Subtenant is in default under any
of the terms, covenants or conditions of this Sublease, either at the time Subtenant exercises the right of first offer or on the commencement date of sublease applicable to the Offered Space, Sublandlord shall have, in addition to all of
Sublandlord’s other rights and remedies provided in this Sublease, the right to terminate such right of first offer upon notice to Subtenant. 

  
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(e)    If Sublandlord and Subtenant are unable to agree on Fair Market Rent pursuant to
subsection 19(c) above, then the parties shall submit the matter to arbitration. The arbitration shall be concluded within ninety (90) days after the date of Subtenant’s Acceptance Notice. To the extent that arbitration has not been
completed prior to the expiration of the original Sublease term, Subtenant shall pay Base Rent at the rate applicable during the last month of the original Sublease term, with an adjustment to be made once Fair Market Rent is ultimately determined
by arbitration. Within ten (10) days of the expiration of the 30-day period described in subsection 19(c) above, each party shall choose an Appraiser and shall send written notice to the other party specifying therein the identity of the
Appraiser. For purposes hereof, “Appraiser” means a real estate broker or MAI designated appraiser, in either case with not less than five (5) years of full time commercial appraisal or brokerage experience in the sub-market area in
which the Offered Space is located and with no prior business dealings with the party appointing such Appraiser. If either party fails to timely appoint an Appraiser, the sole Appraiser appointed shall determine the Base Rent to be charged during
the new sublease term, based on the criteria described above. If two Appraisers are appointed, they shall immediately meet and attempt to agree upon such Base Rent. If they are unable to do so within fifteen (15) days after their first meeting,
they shall jointly appoint a third Appraiser and the third Appraiser shall determine Fair Market Rent for the applicable extension period within ten (10) days of his/her appointment. If the two Appraisers are unable to agree upon such third
Appraiser, either party may petition the Presiding Judge of the Superior Court of the City and County where the Sublease Premises are located to appoint such third Appraiser. The determination of Base Rent as provided herein shall be binding upon
the parties hereto. Promptly upon such determination, the parties shall execute a sublease specifying the Base Rent payable during the sublease term. 
 20.    Surrender of Sublease Premises. Upon the expiration or earlier termination of this Sublease, Subtenant shall surrender the Sublease Premises in the same condition as they
were in on the “Term Commencement Date” of the Master Lease, ordinary wear and tear excepted. 

21.    No Third Party Rights. The benefit of the provisions of this Sublease is expressly
limited to Sublandlord and Subtenant and their respective permitted successors and assigns. Under no circumstances will any third party be construed to have any rights as a third party beneficiary with respect to any of said provisions. 

22.    Quiet Enjoyment. Subject to Section 14(b)(ii) above, so long as Subtenant timely
pays Rent and performs its obligations under this Sublease, Sublandlord shall take no action, or fail to take any action, which would interfere with the right of Subtenant to peaceably have, hold and enjoy the Sublease Premises during the Sublease
term. 
 23.    Counterparts. This Sublease may be signed in two or more
counterparts, each of which shall be deemed an original and all of which shall constitute one agreement 

  
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IN WITNESS WHEREOF, the parties have executed this
Sublease as of the date first written above. 
  

							
	 SUBLANDLORD: DIADEXUS, INC.,
	 	 SUBTENANT: VIROLOGIC, INC.,

	 a Delaware corporation
	 	 a Delaware corporation



							
				
	 By:
	 	 /s/ Sharon Tetlow
	 	 By:    
	 	 /s/ William D.
Young



							
	 Print Name:
	 	 Sharon Tetlow
	 	 Print Name:
	 	 William D. Young




							
	 Its:
	 	 CEO
	 	 Its:
	 	 WOY



  
 10 









  
 Exhibit A

 Master Lease 
 [to be attached] 

  
 11 









  
 Exhibits B

 Depiction of Sublease Premises 
 [to be attached] 

  
 12 









  

 

 


  
 13 









  

 

 


  
 14 









  
 Exhibit C

 Consent to Sublease 
 [to be attached] 

  
 15 









  
 CONSENT TO SUBLEASE

 This CONSENT TO SUBLEASE (this “Sublease Consent”), effective as of June 1, 2002
(the “Effective Date”), is entered into by (i) ARE-TECHNOLOGY CENTER SSF, LLC, a Delaware limited liability company (“Landlord”), (ii) VIROLOGIC, INC., a Delaware corporation (“Current
Tenant”), and (iii) DIADEXUS, INC., a Delaware corporation (“New Tenant”), as follows: 

RECITALS 
 A.    Current Tenant currently leases the entire building located at 343 Oyster Point Boulevard in South San Francisco, California (the “Premises”) from Landlord
pursuant to a certain Lease made as of November 23, 1999, between Landlord’s predecessor-in-interest, Trammell Crow Northern California Development, Inc., and Current Tenant, as amended by a certain First Amendment To Lease Agreement dated
as of February     , 2000, between Landlord and Current Tenant (collectively, the “Lease”). All initially capitalized terms not expressly defined in this Sublease Consent shall have the meanings given to
such terms in the Lease unless the context clearly indicates otherwise. 

B.    Concurrently with this Sublease Consent, (i) Current Tenant is assigning to New Tenant of
all of Current Tenant’s right, title, and interest in and to the Lease, and (ii) Current Tenant is selling and transferring to New Tenant all of Current Tenant’s ownership interest in and to all of the Movable Equipment and Trade
Fixtures described in Exhibit B-3 of the Lease, excluding items 1 through 6 described in such Exhibit B-3. The agreements of Landlord, Current Tenant, and New Tenant (each, a “Party” and collectively, the
“Parties”) regarding the transactions described in this Recital (the “Assignment Transactions”) are contained in a certain Consent To Assignment and Modification of Lease of even date herewith (the
“Assignment Consent”). 
 C.    New Tenant currently occupies 40,350 square
feet of the Premises pursuant to a certain Sublease dated May 17, 2001, between Current Tenant (as sublandlord) and New Tenant (as subtenant) (the “Current Sublease”). Among other things, Landlord consented to the Current
Sublease pursuant to a certain Consent To Sublease made as of May 17, 2001, among Landlord, Current Tenant, and New Tenant (“Consent To Current Sublease”). Current Tenant and New Tenant have entered into various agreements
pursuant to which, among other things, (i) New Tenant is subleasing to Current Tenant 13,630 square feet of space in the Premises until September 30, 2003, with an option to extend the term thereof until December 31, 2003, and
(ii) Current Tenant and New Tenant are terminating the Current Sublease. 
 D.    New
Tenant and Current Tenant expressly acknowledge and agree that the transactions described in Recital C above (the “Sublease Transactions”) require Landlord’s consent. 

NOW, THEREFORE, in consideration of the foregoing Recitals, which are incorporated herein by this reference, the
covenants in this Sublease Consent, and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the Parties hereby agree as follows: 







  

1.    Consent To New Sublease and Termination of Current Sublease. 

(a)    Current Tenant and New Tenant each hereby represents and warrants to Landlord that:
(i) attached to this Sublease Consent as Attachment 1 is a correct and complete copy of the Sublease (the “New Sublease”) pursuant to which New Tenant is subleasing to Current Tenant, and Current Tenant is subleasing
from New Tenant, the 13,630 square feet of space in the Premises occupied by Current Tenant as of the day immediately prior to the Effective Date (the “New Sublease Premises”); (ii) the effectiveness of the New Sublease is not
subject to any oral or written agreement between Current Tenant and New Tenant that provides for a revocation, rescission, cancellation, termination, or other nullification of the New Sublease upon the occurrence or failure to occur of any other
event (other than a breach or default under such New Sublease); (iii) attached to this Sublease Consent as Attachment 2 is a correct and complete copy of the Sublease Termination Agreement (the “Current Sublease
Termination”) pursuant to which Current Tenant and New Tenant have terminated the Current Sublease as of the Effective Date, and (iv) the effectiveness of the Current Sublease Termination is not subject to any oral or written agreement
between Current Tenant and New Tenant that provides for a revocation, rescission, cancellation, or other nullification of the Current Sublease Termination upon the occurrence or failure to occur of any other event. Subject to paragraphs
(b) through (j) below, Landlord hereby consents to New Tenant’s sublease of the New Sublease Premises to Current Tenant, in accordance with the terms, covenants, and conditions in the New Sublease. Subject to paragraph
(k) below, Landlord hereby consents to the termination of the Current Sublease, in accordance with the terms, covenants, and conditions in the Current Sublease Termination. Landlord neither approves nor disapproves any of the terms or
conditions in the New Sublease or in the Current Sublease Termination, which are and will remain matters solely between Current Tenant and New Tenant. 
 (b)    The New Sublease shall be a sublease only and not an assignment of the Lease with respect to the New Sublease Premises, and there shall be no further subletting or assignment of
any part of the Premises (including, without limitation, the New Sublease Premises) except in strict accordance with the terms, covenants, and conditions in the Lease. Further, any modification or extension of the New Sublease without
Landlord’s prior written consent (which consent may not be unreasonably withheld, conditioned, or delayed) shall be void and of no force or effect. 
 (c)    All of the terms, covenants, and conditions in the New Sublease shall be subordinate and subject to (i) all of the terms, covenants, and conditions in the Lease,
(ii) all superior ground leases, mortgages, deeds of trust, and other liens now or hereafter placed against the real property of which the Premises are a part and to all advances secured thereby and to all renewals, modifications,
consolidations, replacements, and extensions thereof, and (iii) all matters of record and all laws, ordinances, and regulations now or hereafter affecting the real property of which the Premises are a part. 

(d)    Nothing contained in the New Sublease shall be construed to modify, waive, impair, or affect
in any way any of the terms, covenants, and conditions in the Lease (including, without limitation, the obligation of the Tenant under the Lease to obtain any required consents for any other or future sublettings or assignments), to waive any
current or future breach of the Lease, to compromise any rights or remedies of Landlord under the Lease against any person or entity liable for the performance thereof, or to enlarge or increase Landlord’s obligations or liabilities under the
Lease (including, without limitation, any liability to the sublessee under the New Sublease (the “New Sublessee”) for any portion of the security deposit held by the sublessor under the New Sublease (the “New
Sublessor”)), it being expressly acknowledged and agreed by the Parties that all of the terms, covenants, and conditions in the Lease shall remain in full force and effect, notwithstanding the New Sublease. Further, the Tenant under the
Lease shall remain liable and responsible for performing and complying with all of the terms, covenants, and conditions in the Lease that are to be performed or complied with by such Tenant for all of the Premises, including, without limitation, the
New Sublease Premises. 

  
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(e)    Current Tenant (in its capacity as the New Sublessee), for the benefit of Landlord, hereby
expressly assumes and agrees to be bound by, and to perform and comply with, all of the obligations of the Tenant under the Lease that are applicable to the New Sublease Premises. 

(f)    Landlord and Current Tenant (in its capacity as the New Sublessee) each hereby releases the
other, and each hereby waives its rights of recovery against the other, for direct or consequential losses or damages arising out of or incident to any perils covered by property insurance carried by such party to the extent of such insurance, and
each hereby waives any right of subrogation that otherwise might exist in or accrue to any person on account thereof. 
 (g)    Any act or omission of the New Sublessee or of anyone claiming under or through the New Sublessee that violates any of the terms, covenants, or conditions of the Lease shall be
deemed a violation of the Lease by the Tenant under the Lease. 
 (h)    Current Tenant (in
its capacity as the New Sublessee) hereby agrees that, upon a default by the Tenant under the Lease, Landlord may proceed, but shall not be required to proceed, directly against such Tenant without first exhausting any other rights or remedies
Landlord may have against any other person or entity liable to Landlord for the same or against any other security for the same. If Landlord gives the New Sublessee notice that the Tenant under the Lease is in default under the Lease, the New
Sublessee thereafter shall make directly to Landlord all payments otherwise due the New Sublessor under the New Sublease, which payments shall be received by Landlord without any liability to the Tenant under the Lease except to credit such payments
against amounts due under the Lease. 
 (i)    New Tenant (in its capacity as the Tenant
under the Lease and its capacity as the New Sublessor) and Current Tenant (in its capacity as the New Sublessee) each hereby acknowledges and agrees that if the Lease is terminated, for any reason, Landlord shall have no liability, responsibility,
or obligation to the New Sublessee, and the New Sublease shall automatically terminate, except as expressly provided below. If the Lease is terminated, for any reason, then, so long as the New Sublessee is not in default under the New Sublease, the
New Sublease shall become a direct lease between Landlord and the New Sublessee, Landlord shall not interfere with or disturb the New Sublessee’s use, possession, and enjoyment of the New Sublease Premises, and the New Sublessee shall attorn to
Landlord and recognize Landlord as the New Sublessor. If the New Sublease becomes a direct lease between Landlord and the New Sublessee, Landlord shall undertake the obligations of the New Sublessor from the date of the termination of the Lease (the
“Lease Termination Date”) through the expiration or earlier termination of the New Sublease, but Landlord, in undertaking such obligations, shall not (i) be liable for any rent or any security deposit paid by the New Sublessee
under the New Sublease, except to the extent actually delivered to Landlord, (ii) be liable for any act, omission, or default of the Tenant under the Lease or of the New Sublessor under the Sublease that arose prior to the Lease Termination
Date, (iii) be subject to any defenses or offsets that the New Sublessee may have against the New Sublessor that arose prior to the Lease Termination Date, (iv) be bound by any changes or modifications made to the New Sublease prior to the
Lease Termination Date without Landlord’s written consent, or (v) be liable for any matters provided in Sections 17 or 18 of the New Sublease. Notwithstanding the termination of the Lease, if the New Sublease becomes a direct
lease between Landlord and the New Sublessee, Landlord shall continue to perform, from the Lease Termination Date through the expiration or earlier termination of the New Sublease, the obligations of Landlord set forth in Paragraphs 8,
10, 24, and 28 of the Lease. 

  
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 (j)
Under no circumstances shall the term of the New Sublease be extended beyond December 31, 2003. 
 (k) As
consideration for Landlord’s consent to the Current Sublease Termination and agreement to forego the periodic bonus rent payments now payable by Current Tenant to Landlord under the Consent To Current Sublease (“Current Sublease Bonus
Rent”), Current Tenant shall pay Landlord a total of $937,546.00 (the “Consideration”), of which $237,546.00 shall be consideration for the Current Sublease Bonus Rent already owed to Landlord by Current Tenant and
$700,000.00 shall be consideration for Landlord’s agreement to forego any other Current Sublease Bonus Rent that would have come due under the Consent To Current Sublease, in accordance with the following schedule: 

 

					
	 Date
	  	 Amount
	 
		
	 06/01/02
	  	$	562,527.60	  
		
	 09/27/02
	  	$	187,509.20	  
		
	 12/28/02
	  	$	187,509.20	  

 The effectiveness of
this Sublease Consent (and of the Assignment Consent) shall not be subject to Current Tenant’s payment of the Consideration to Landlord, and Landlord shall have no right to revoke, rescind, cancel, terminate, or otherwise nullify this Sublease
Consent (or the Assignment Consent) if Current Tenant fails to pay to Landlord any part of the Consideration. Landlord’s remedy in such an event shall be to pursue its rights and/or remedies against Current Tenant at law or in equity and/or to
seek to recover from Current Tenant any unpaid portion of the Consideration plus any actual or consequential damages suffered by Landlord (including, without limitation, reasonable attorneys’ fees and disbursements) as a result of Current
Tenant’s breach. 
 2.    Miscellaneous Provisions. 

(a)    Condition of New Sublease Premises: Prior to the Effective Date, Current Tenant
has been in possession of, and conducting business in, the New Sublease Premises. Accordingly, (i) Current Tenant hereby expressly acknowledges, for the benefit of Landlord, that Current Tenant has accepted the New Sublease Premises in their
“as-is” condition, without any qualifications, restrictions, or limitations, and (ii) all currently installed utility systems and related infrastructure within the Sublease Premises (collectively, “Infrastructure”)
shall remain in their current location after the Effective Date. Landlord’s execution of this Sublease Consent, in and by itself, shall not constitute or give rise to, and under no circumstances shall such execution, in and by itself, be
deemed, construed, or interpreted as constituting or giving rise to, any representation or warranty by Landlord regarding the condition of any portion or component of the New Sublease Premises (including, without limitation, all currently installed
Infrastructure). 

  
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(b)    Commissions: Current Tenant shall be solely responsible and liable for, and under
no circumstances shall Landlord or New Tenant have any responsibility or liability for, any commission, fee, or other payment (a “Commission”) due to CRESA Partners in connection with the Sublease Transactions. Current Tenant hereby
indemnifies and agrees to protect, defend, and hold Landlord and New Tenant harmless from and against any and all claims, losses, damages, costs, and expenses (including reasonable attorneys’ fees and disbursements) that may be incurred by
Landlord or New Tenant, respectively, with respect to any Commissions payable in connection with the Sublease Transactions that result from the actions of Current Tenant. New Tenant hereby indemnifies and agrees to protect, defend, and hold Landlord
and Current Tenant harmless from and against any and all claims, losses, damages, costs, and expenses (including reasonable attorneys’ fees and disbursements) that may be incurred by Landlord or Current Tenant, respectively, with respect to any
Commissions payable in connection with the Sublease Transactions that result from the actions of New Tenant. 

(c)    Counterparts: This Sublease Consent may be executed in any number of
counterparts, each of which shall be deemed an original and all of which, taken together, shall constitute a single agreement with the same effect as if all Parties had signed the same signature page. Any signature page from any counterpart of this
Sublease Consent, signed only by one Party, may be detached from such counterpart and re-attached to any other counterpart of this Sublease Consent that has a signature page signed only by one or both of the other Parties. 

(d)    Notices: All notices or other communications hereunder shall be in writing and
may be given personally, by reputable overnight delivery service (including overnight U.S. mail), or by facsimile transmission (with in the case of a facsimile transmission, confirmation by reputable overnight delivery service) to the Parties at the
following addresses: 
  

							
	If to Landlord:	  	With a copy to:
		
	 c/o Alexandria Real Estate Equities, Inc.
 135 N. Los Robles Ave., Suite 250
 Pasadena, California 91101
	  	McKay, Meyer and Herbert
 1801 Century Park East, 25th Floor
 Los Angeles, California 90067-2327

	Attention:	  	Corporate Secretary	  	Attention:	  	David S. Meyer, Esq.
	Re:	  	343 Oyster Point	  	Re:	  	343 Oyster Point
	Facsimile:	  	626-578-0770	  	Facsimile:	  	310-772-0239
		
	If to New Tenant:	  	With a copy to:
		
	 diaDexus, Inc.
 343
Oyster Point Boulevard
 South San Francisco, CA 94080
	  	Latham & Watkins
 505 Montgomery Street, Suite
1900
 San Francisco, California 94111

	Attention:	  	Ms. Sharon Tetlow	  	Attention:	  	Kenneth Whiting, Esq.
	Re:	  	Virologic, Inc.	  	Re:	  	diaDexus, Inc.
	Facsimile:	  	650-246-6503	  	Facsimile:	  	415-395-8095


  
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	 If to Current Tenant:
	  	 With a copy to:

		
	 Virologic, Inc.
	  	 Virologic, Inc.

	 345 Oyster Point Boulevard
	  	 345 Oyster Point Boulevard

	 South San Francisco, CA 94080
	  	 South San Francisco, CA 94080

	 Attention:
	  	 Ms. Karen Wilson
	  	 Attention:
	  	 Kathy Hibbs, Esq.

	 Re:
	  	 343 Oyster Point
	  	 Re:
	  	 Virologic, Inc.

	 Facsimile:
	  	 650-635-1111
	  	 Facsimile:
	  	 650-635-1111


 (e)    Amendments; Waivers: No amendment, modification, supplement, or waiver of this Sublease Consent shall be binding unless executed in writing by the Party to be
bound thereby. No waiver of any provision of this Sublease Consent shall be deemed a waiver of any other provision of this Sublease Consent (whether or not similar), nor shall such waiver be deemed a continuing waiver unless otherwise expressly
provided. 
 (f)    Construction: This Sublease Consent shall not be construed
more strictly against one Party than against any other Party merely by virtue of the fact that this Sublease Consent may have been prepared by counsel for one of the Parties. Further, no inferences are to be drawn, and no conclusions are to be made,
based on the fact that a particular provision contained in a draft of this Sublease Consent is not included in the executed version of this Sublease Consent, and no differences between drafts of this Sublease Consent and the executed version of this
Sublease Consent may be used as evidence of the Parties’ intended interpretation of any of the terms of this Sublease Consent. 
 (g)    Integration: This Sublease Consent and the Assignment Consent constitute the entire agreement among the Parties with respect to Landlord’s consent to the
Sublease Transactions and the Assignment Transactions and is intended by the Parties to be the final expression and the complete and exclusive statement of the terms of such agreement, and supersedes all prior agreements, understandings,
negotiations, and discussions of the Parties, whether oral or written, and there are no other agreements, express or implied, made by the Parties in connection with Landlord’s consent to the Sublease Transactions and the Assignment
Transactions, except as may be specifically set forth in any documents delivered pursuant hereto or in connection herewith. 
 (h)    Further Assistance: Each Party agrees to perform, execute, and/or deliver or cause to be performed, executed, and/or delivered any further acts, instruments, and
assurances as may be reasonably required to accomplish the purposes of this Sublease Consent. 

  
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(i)    Successors and Assigns; Third Parties: All of the rights, duties, benefits,
liabilities, and obligations of the Parties under this Sublease Consent shall inure to the benefit of, and be binding upon, their respective successors and assigns. Nothing expressed or implied in this Sublease Consent is intended or shall be
construed to confer upon or give to any person or entity, other than the Parties and their successors or assigns, any rights or remedies under or by reason of this Sublease Consent. 

IN WITNESS WHEREOF, the Parties have executed this Sublease Consent effective as of the Effective Date.

  

							
	 LANDLORD:

	
	 ARE-TECHNOLOGY CENTER SSF, LLC,

a Delaware limited liability company

		
	 By:        
	 	 ALEXANDRIA REAL ESTATE EQUITIES, L.P.,

a Delaware limited partnership, managing member

			
		 	 By:        
	 	 ARE-QRS CORP.,
a Maryland corporation, general partner

				
		 		 	 By:
	 	 /s/ Jim Ricardson

		 		 	 Print Name:
	 	 Jim Ricardson

		 		 	 Print Title:
	 	 President

	
	 CURRENT TENANT:

	
	VIROLOGIC, INC., a Delaware corporation
		
	 By:
	 	 /s/ William D. Young

	Print Name:	 	 William D. Young

	Print Title:	 	 Chairman & CEO

	
	NEW TENANT:
	
	DIADEXUS, INC., a Delaware corporation
		
	By:	 	 /s/ Sharon Tetlow

	Print Name:	 	 Sharon Tetlow

	Print Title:	 	 CFO




  
 7 








 ATTACHMENT 1 
 Copy of New Sublease 
 [ See Following Page(s) ] 

  
 8