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EXHIBIT 10.10

Pharma Services Holding, Inc.
c/o One Equity Partners
230 Park Avenue, 18th Floor
New York, New York 10022

October 30, 2003

Oppel Greeff
111 Beaver Dam Run
Durham, NC 27703

Re: Opportunity to Purchase Shares

Dear Oppel:

As you know, on September 25, 2003, Quintiles Transnational Corp.
(Quintiles), became an indirect wholly-owned subsidiary of Pharma Services
Holding, Inc. (the Company). We are pleased to offer you the opportunity to
purchase shares of common stock (Shares) of the Company pursuant to the
Companys Stock Incentive Plan (the Plan) and on the terms and conditions set
forth below.



|1. |  | Number of Shares. You will have the opportunity to purchase up to
450,000 Shares.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
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|2. |  | Purchase Price. The purchase price per Share is $0.2438, for a total of
$109,710 if you purchase all of the Shares, payable by check to the
Company.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
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|3. |  | Vesting. Your Shares when issued will be Unvested Shares (as defined
in the Plan) and will become Vested Shares (as defined in the Plan) as
to 20% of the total number awarded on the 25th day of each September,
beginning September 25, 2004 and ending September 25, 2008, provided (i)
all Shares will become Vested Shares upon a Sale of the Company, as
defined in the Plan, and the Committee will not exercise its discretion to
provide otherwise, (ii) all Shares will become Vested Shares upon your
termination of employment by reason of your death or pursuant to Section
4.3(ii) of your Executive Employment Agreement (physical or mental
inability to perform), and (iii) upon your termination of employment under
circumstances entitling you to severance benefits pursuant to Section 5.2
of your Executive Employment Agreement, such number of Unvested Shares
shall become Vested Shares as is equal to the total number of Shares set
forth in paragraph 1 above multiplied by the vesting percentage, as
defined below. In no event will any Unvested Shares become Vested Shares
following your termination of employment with the Company and its
subsidiaries for any reason (after taking into account any vesting that
occurs upon termination of employment pursuant to clauses (ii) and (iii)
of the preceding sentence). For purposes of the foregoing, vesting
percentage means the 20% multiplied by a fraction, the numerator of which
is the





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|   |  | number of days that have elapsed from the 25th day of September that
immediately precedes the date of your termination of employment through the
date of such termination, and the denominator of which is 365, provided that
if the date of your termination of employment falls on the 25th day of any
September, the vesting percentage shall be zero.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
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|4. |  | Repurchase Right; Restrictions on Shares. Upon your termination of
employment with the Company and its subsidiaries for any reason, the
Company and certain other persons may, but are not obligated to,
repurchase your Shares. As further described in Section 8 of the Plan,
the repurchase price to be paid by the Company depends upon whether the
Shares are Unvested Shares or Vested Shares, and the circumstances of your
termination. Generally, Unvested Shares may be repurchased for the price
you paid for them, and Vested Shares may be repurchased for their Fair
Market Value, as defined in the Plan, but under certain circumstances
described in the Plan, even your Vested Shares may be repurchased for the
price you paid for them. Also, as further described in Section 8 of the
Plan, the Shares are generally nontransferable prior to a Sale of the
Company or Qualified Public Offering (as defined in the Plan), the
Company has the right to require that you participate in a Sale of the
Company (a Drag-Along Right), and your right to vote with respect to the
election of directors of the Company may be restricted. For purposes of
Section 8(c)(ii) of the Plan (Repurchase Right), in making a good faith
determination of Fair Market Value, the Committee will take into account
the most recent outside event pursuant to which a value of a Share can be
implied (including, without limitation, an equity issuance, stock option
grant or valuation by an appraisal firm, investment bank or similar
organization), provided that if no such event has occurred within the
preceding 12 months, the Committee shall obtain a new valuation by an
appraisal firm, investment bank or similar organization, and shall take
such valuation into account in determining Fair Market Value. For
purposes of the proviso contained in Section 8(c)(ii) of the Plan, clause
(x) thereof shall not apply, and clause (z) shall apply only if the breach
referred to therein is material.
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|5. |  | Taxes. A separate information statement describing the tax
considerations relating to your purchase of Shares will be provided to
you.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
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|6. |  | Representations.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       



| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
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| | (a) Authority. You have the requisite power, authority and capacity to
execute this Agreement and to perform your obligations under this Agreement
and to consummate the transactions contemplated hereby. The Acceptance has
been duly and validly executed and delivered by you and constitutes your
legal, valid and binding obligation, enforceable against you in accordance
with its terms, except to the extent that such validly binding effect and
enforceability may be limited by applicable bankruptcy, reorganization,
insolvency, moratorium and other laws relating to or affecting creditors
rights generally.



| |                                                                                                                                                                                                                 
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| | (b) Brokers. No Person is entitled to any brokers, finders,
financial advisers or other similar fee or commission in connection with
the transactions contemplated hereby based upon any action taken by you.

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| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
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| | (c) Shares Unregistered; Accredited Investor. You acknowledge that (i)
the offer and sale of the Shares has not been registered under applicable
securities laws; (ii) the Shares being purchased by you must be held
indefinitely; (iii) there is no established market for the Shares and it is
not anticipated that there will be any such market for the Shares in the
foreseeable future; (iv) you are an accredited investor under Rule 501(a)
of the Securities Act of 1933; (v) your knowledge and experience in
financial and business matters are such that you are capable of evaluating
the merits and risks of your investment in the Shares, or you have been
advised by a representative (not affiliated with the Company) possessing
such knowledge and experience; (vi) you and your representatives, including
your professional, financial, tax and other advisors, if any, have carefully
considered your proposed investment in the Shares, and you understand and
have taken cognizance of (or have been advised by your representatives as
to) the risk factors related to the acquisition of such Shares, and no
representations or warranties have been made to you or your representatives
concerning the Shares, the Company or the Companys business, operations,
financial condition or prospects or other matters; (vii) in making your
decision to purchase the Shares, you have relied upon independent
investigations made by you and, to the extent believed by you to be
appropriate, your representatives, including your professional, financial,
tax and other advisors, if any; (viii) you and your representatives have
been given the opportunity to request to examine all documents of, and to
ask questions of, and to receive answers from, the Company and its
representatives concerning the terms and conditions of the acquisition of
the Shares and to obtain any additional information which you or your
representatives deem necessary; (ix) you are acquiring the Shares for the
purpose of investment and not with a view to, or for resale in connection
with, the distribution thereof, and not with any present intention of
distributing such Shares and you have no present plan or intention to sell
any of the Shares; and (x) the Company is allowing you to acquire the Shares
in reliance upon these representations and warranties.



|7. |  | Subject to Plan. The opportunity to purchase the Shares is being made to
you pursuant to the Plan, a copy of which is attached, and such purchase,
holding and transfer of the Shares is subject to the terms of the Plan in
all respects.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
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|8. |  | Conditions. Our offer and your acceptance of our to purchase Shares is
conditional upon your execution of an amendment to your Executive
Employment Agreement in the form attached as Exhibit A no later than
November 17, 2003.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
|  
|9. |  | Acknowledgement. You acknowledge: (i) that the Plan is discretionary in
nature and may be suspended or terminated by the Company at any time; (ii)
that this grant of the opportunity to purchase Shares is a one-time
benefit, which does not create any contractual or other right to receive
future awards under the Plan, or benefits in lieu of awards; (iii) that
all determinations with respect to any such future grants, including, but
not limited to, the times when awards shall be granted, the number of
shares subject to each award, the exercise or purchase price, and the time
or times when each award shall vest, will be at the sole discretion of the
Committee; (iv) that your participation in the Plan shall not create a
right to further employment with the Company or its affiliates and shall
not interfere with the Companys, its affiliates or your ability to
terminate your employment relationship at any time with or

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|    |  | without cause; (v) that your participation in the Plan is voluntary; (vi)
that the value of this award is an extraordinary item of compensation which
is outside the scope of your employment contract, if any; and (vii) that
award is not part of normal or expected compensation for purposes of
calculating any severance, resignation, redundancy, end of service payments,
bonuses, long-service awards, pension or retirement benefits or similar
payments.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
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|10. |  | Employee Data Privacy. As a condition of the grant of this opportunity
to purchase Shares, you consent to the collection, use and transfer of
personal data as described in this paragraph 10. You understand that the
Company and its Affiliates hold certain personal information about you
including, but not limited to, your name, home address and telephone
number, date of birth, social security number, salary, nationality, job
title, shares of common stock or directorships held in the Company,
details of all Options or other entitlement to shares of common stock
awarded, cancelled, exercised, vested, unvested or outstanding in your
favor, for the purpose of managing and administering the Plan (Data).
You further understand that the Company and/or its Affiliates will
transfer Data amongst themselves as necessary for the purposes of
implementation, administration and management of your participation in the
Plan, and that the Company and/or any of its Affiliates may each further
transfer Data to any third parties assisting the Company in the
implementation, administration and management of the Plan. You understand
that these recipients may be located in your country of residence or
elsewhere, such as the United States. You authorize them to receive,
possess, use, retain and transfer Data in electronic or other form, for
the purposes of implementing, administering and managing your
participation in the Plan, including any requisite transfer of such Data
as may be required for the administration of the Plan and/or the
subsequent holding shares of common stock on your behalf to a broker or
other third party with whom the shares acquired on exercise may be
deposited. You understand that he or she may, at any time, view the Data,
require any necessary amendments to it or withdraw the consent herein in
writing by contacting the local human resources representative.

Please indicate the number of Shares you wish to purchase on the Acceptance
below. Please return a signed copy of the Acceptance, along with a check for
the purchase price ($0.2438 per Share) made payable to Pharma Services Holding,
Inc., to Gary Rothstein, Esq., Morgan Lewis & Bockius, LLP, 101 Park Avenue,
New York, NY 10178. Your Acceptance and payment must be received no later than
November 17, 2003.



| | Sincerely yours,             
| | -----------------------------
| |                              
| | PHARMA SERVICES HOLDING, INC.

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ACCEPTANCE OF OFFER
TO PURCHASE COMMON SHARES OF PHARMA SERVICES HOLDING, INC.

I, Oppel Greeff hereby accept the offer made to me by Pharma Services Holding,
Inc. (Pharma) to purchase 450,000 shares of common stock of Pharma at a price
per share of $0.2438 pursuant to and in accordance with the terms of a letter
to me from Pharma dated October 30, 2003, and enclose a check for $109,710.

|                 |  |         
|---------------- |  | --------
|/s/ Oppel Greeff |  | 12/06/03
|                 |  |         
|Oppel Greeff     |  | Date    

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