| Registration      Statements on Form S-8: |
|-------------------------------------------|

| Name                                                 |   | Registration Number            |   | Date Filed           |
|------------------------------------------------------|--------|--------------------------------|--------|----------------------|
| 1997      Equity Incentive Plan                      |   |                           |   |                 |
| Employee      Stock Purchase Plan                    |   |                           |   |                 |
| 1997      Non-Employee Directors’ Stock        |   |                           |   |                 |
|       Option      Plan |   | 333-53083                      |   | May      20, 1998    |
|                                                 |   |                           |   |                 |
| Employee      Stock Purchase Plan                    |   |                           |   |                 |
| 1997      Non-Employee Directors’ Stock        |   |                           |   |                 |
|       Option      Plan |   | 333-80931                      |   | June      17, 1999   |
|                                                 |   |                           |   |                 |
| 1997      Equity Incentive Plan                      |   |                           |   |                 |
| Employee      Stock Purchase Plan                    |   | 333-44562                      |   | August      25, 2000 |
|                                                 |   |                           |   |                 |
| 1997      Equity Incentive Plan                      |   |                           |   |                 |
| Employee      Stock Purchase Plan                    |   |                           |   |                 |
| 1997      Non-Employee Directors’ Stock        |   |                           |   |                 |
|       Option      Plan |   | 333-92080                      |   | July      8, 2002    |
|                                                 |   |                           |   |                 |
| 1997      Equity Incentive Plan                      |   |                           |   |                 |
| Employee      Stock Purchase Plan                    |   | 333-107096                     |   | July      16, 2003   |
|                                                 |   |                           |   |                 |
| 1997      Non-Employee Directors’ Stock        |   |                           |   |                 |
|       Option      Plan |   | 333-127190                     |   | August      4, 2005  |
|                                                 |   |                           |   |                 |
|                                                 |   |                           |   |                 |
|                                                 |   | /s/      Ernst & Young LLP |   |                 |
|                                                 |   |                           |   |                 |
| Baltimore,      Maryland                             |   |                           |   |                 |
| March      14, 2008                                  |   |                           |   |                 |