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                                                                   EXHIBIT 10.69

                        AMENDMENT TO EMPLOYMENT AGREEMENT

        THIS AMENDMENT TO EMPLOYMENT AGREEMENT (this "Amendment") is made and
entered into as of July 9, 1997, by and between GENE LOGIC INC., a Delaware
Corporation (the "Company"), and ERIC M. EASTMAN ("Executive").

        WHEREAS, the Company and Executive previously entered into an Employment
Agreement dated September 7, 1996 (the "Employment Agreement") which, among
other things, provides for the automatic vesting of all outstanding options to
purchase the Company's Common Stock held by the Executive upon a change of
control of the Company (the "Vesting Provision"); and

        WHEREAS, the Company and Executive desire to amend the Employment
agreement to amend and restate the Vesting Provision.

        NOW, THEREFORE, the parties hereto, in consideration of the mutual
promises and agreements set forth below, hereby agree to amend the Employment
Agreement as follows:

     1.   RESTATEMENT OF VESTING PROVISION. Section 3.1 of the Employment
Agreement shall be amended and restated to read in its entirety as follows:

          "3.1 Incentive Stock Options. Upon commencement of the term of
     employment engaged by this Agreement, the Company shall grant to Eastman
     incentive stock options to purchase 75,000 shares of the Company's Common
     Stock at a purchase price per share of $0.15 per share. While this
     Agreement remains in force, such options shall become exercisable according
     to the following schedule: twenty-five percent (25%) upon the date of
     commencement and thereafter at the rate of 1/36th each month for 36 months
     beginning upon the first anniversary of such date. In the event of: (i) a
     merger or consolidation of the Company with another corporation, not
     including any merger or consolidation if immediately thereafter the
     stockholders of the Company immediately before such transaction own shares
     representing more than 50% of the outstanding voting securities of the
     surviving corporation, (ii) a sale of shares by the stockholders of the
     Company if immediately thereafter the stockholders of the Company
     immediately before such sale own shares representing less than 50% of the
     outstanding voting securities of the surviving corporation, or (iii) a sale
     of all or substantially all of the Company's assets, all options to
     purchase Common Stock of the Company held by Eastman that have not
     previously vested under the terms of the applicable Option Agreements shall
     vest immediately upon the closing of such transaction. In the event of an
     underwritten initial public offering of the Company's Common Stock, to the
     extent at least 80% of the aggregate of the


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     shares subject to outstanding options to purchase Common Stock of the
     Company held by Eastman (other than any such options granted immediately
     prior to and in contemplation of such initial public offering) have not
     previously vested under the terms of the applicable Option Agreements, then
     the vesting of such options shall be accelerated such that 80% of the
     shares subject to each such option shall be vested as of the closing of
     such initial public offering and the remaining 20% of the shares subject to
     each such option shall vest 180 days from the closing of such initial
     public offering. If, in the event of an underwritten initial public
     offering of the Company's Common Stock, 80% or more of the aggregate of the
     shares subject to outstanding options to purchase Common Stock of the
     Company held by Eastman (other than any such options granted immediately
     prior to and in contemplation of such initial public offering) have
     previously vested, then any remaining unvested shares subject to such
     options shall vest 180 days from the closing of such initial public
     offering.

     2.      EFFECTIVE DATE.  This Amendment shall be effective as of the date
of the Employment Agreement. Except as amended herein, or as otherwise agreed to
in writing by the Company and Executive, all terms of the Employment Agreement
shall remain in full force and effect.

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             IN WITNESS WHEREOF, the parties have executed this Amendment to
        Employment Agreement as of the date first above written.

        THE COMPANY:                               EXECUTIVE:

        GENE LOGIC INC.
        a Delaware Corporation

        By: /s/ MICHAEL BRENNAN                      /S/ ERIC M. EASTMAN
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        Title:  President & CEO                           Eric M. Eastman
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