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UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, DC 20549





FORM 10-Q





Mark One



|x | QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(D) OF THE SECURITIES EXCHANGE ACT OF 1934
|- | ---------------------------------------------------------------------------------------

FOR THE QUARTERLY PERIOD ENDED MARCH 31, 2008

Or



| ̈ | TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(D) OF THE SECURITIES EXCHANGE ACT OF 1934
|- | ----------------------------------------------------------------------------------------

FOR THE TRANSITION PERIOD FROM  TO

Commission File Number: 000-31255





ISTA PHARMACEUTICALS, INC.

(Exact name of registrant as specified in its charter)







|                                                               |  |                                  
|-------------------------------------------------------------- |  | ---------------------------------
|DELAWARE                                                       |  | 33-0511729                       
|(State or other jurisdiction of incorporation or organization) |  | (IRS Employer Identification No.)

15295 Alton Parkway, Irvine, California 92618

(Address of principal executive offices)

(949) 788-6000

(Registrants telephone number, including area code)





Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter
period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. x Yes  ̈ No

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company.
See the definitions of large accelerated filer, accelerated filer and smaller reporting company in Rule 12b-2 of the Exchange Act:



|                                                                      |  |                            
|--------------------------------------------------------------------- |  | ---------------------------
|Large accelerated filer  ̈                                             |  | Accelerated filer x        
|Non-accelerated filer  ̈ (Do not check if a smaller reporting company) |  | Smaller reporting company  ̈

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange
Act). Yes  ̈ No x

The number of shares of the registrants
common stock, $0.001 par value, outstanding as of March 31, 2008 was 33,029,326.









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TABLE OF CONTENTS



|                                         |  |                                                                                                    |  |        
|---------------------------------------- |  | -------------------------------------------------------------------------------------------------- |  | -------
|                                         |  |                                                                                                    |  | Page No
|PART I FINANCIAL INFORMATION (unaudited) |  | 1                                                                                                 
|                                         |  |                                                                                                   
|Item 1                                   |  | Condensed Consolidated Financial Statements                                                        |  | 1      
|                                         |  |                                                                                                   
|                                         |  | Condensed Consolidated Balance Sheets  March 31, 2008 and December 31, 2007                       |  | 1      
|                                         |  |                                                                                                   
|                                         |  | Condensed Consolidated Statements of Operations  Three-Month Period Ended March 31, 2008 and 2007 |  | 2      
|                                         |  |                                                                                                   
|                                         |  | Condensed Consolidated Statements of Cash Flows  Three-Month Period Ended March 31, 2008 and 2007 |  | 3      
|                                         |  |                                                                                                   
|                                         |  | Notes to Condensed Consolidated Financial Statements                                               |  | 4      
|                                         |  |                                                                                                   
|Item 2                                   |  | Managements Discussion and Analysis of Financial Condition and Results of Operations              |  | 11     
|                                         |  |                                                                                                   
|Item 3                                   |  | Quantitative and Qualitative Disclosure About Market Risk                                          |  | 15     
|                                         |  |                                                                                                   
|Item 4                                   |  | Controls and Procedures                                                                            |  | 16     
|                                         | 
|PART II OTHER INFORMATION                |  | 17                                                                                                
|                                         |  |                                                                                                   
|Item 1A                                  |  | Risk Factors                                                                                       |  | 17     
|                                         |  |                                                                                                   
|Item 6                                   |  | Exhibits                                                                                           |  | 18     
|                                         |  |                                                                                                   
|                                         |  | Signatures                                                                                         |  | 19     
|                                         |  |                                                                                                   
|                                         |  | Index to Exhibits                                                                                  |  | 20     



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##### Table of Contents

PART I FINANCIAL INFORMATION



|Item 1 | Condensed Consolidated Financial Statements
|------ | -------------------------------------------

ISTA Pharmaceuticals, Inc.

Condensed Consolidated Balance Sheets

(in thousands, except share and per share data)

(unaudited)



|                                                                                                                                                                                                                                  |  |               |          |   |                  |   |          |  
|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- |  | ------------- | -------- | - | ---------------- | - | -------- | -
|                                                                                                                                                                                                                                  |  | March 31,2008 |          |   | December 31,2007 |  
|ASSETS                                                                                                                                                                                                                            |  |               |          |   |                  |   |          |  
|Current assets:                                                                                                                                                                                                                   |  |               |          |   |                  |   |          |  
|Cash and cash equivalents                                                                                                                                                                                                         |  | $             | 22,401   |   |                  | $ | 25,500   |  
|Short-term investments  available for sale securities                                                                                                                                                                            |  |               | 7,227    |   |                  |   | 20,640   |  
|Accounts receivable, net of allowances of $307 in 2008 and $187 in 2007                                                                                                                                                           |  |               | 12,183   |   |                  |   | 11,161   |  
|Inventory, net of allowances of $707 in 2008 and $396 in 2007                                                                                                                                                                     |  |               | 2,374    |   |                  |   | 2,294    |  
|Other current assets                                                                                                                                                                                                              |  |               | 2,212    |   |                  |   | 2,122    |  
|                                                                                                                                                                                                                                  |  |               |          |   |                  |   |          |  
|Total current assets                                                                                                                                                                                                              |  |               | 46,397   |   |                  |   | 61,717   |  
|Property and equipment, net                                                                                                                                                                                                       |  |               | 5,512    |   |                  |   | 5,389    |  
|Available for sale securities                                                                                                                                                                                                     |  |               | 4,498    |   |                  |   |         |  
|Deferred financing costs                                                                                                                                                                                                          |  |               | 1,821    |   |                  |   | 1,963    |  
|Restricted cash                                                                                                                                                                                                                   |  |               | 1,600    |   |                  |   | 2,400    |  
|Deposits and other assets                                                                                                                                                                                                         |  |               | 211      |   |                  |   | 247      |  
|                                                                                                                                                                                                                                  |  |               |          |   |                  |   |          |  
|Total assets                                                                                                                                                                                                                      |  | $             | 60,039   |   |                  | $ | 71,716   |  
|                                                                                                                                                                                                                                  |  |               |          |   |                  |   |          |  
|LIABILITIES AND STOCKHOLDERS DEFICIT                                                                                                                                                                                             |  |               |          |   |                  |   |          |  
|Current liabilities:                                                                                                                                                                                                              |  |               |          |   |                  |   |          |  
|Accounts payable                                                                                                                                                                                                                  |  | $             | 1,746    |   |                  | $ | 3,661    |  
|Accrued compensation and related expenses                                                                                                                                                                                         |  |               | 2,478    |   |                  |   | 3,696    |  
|Accrued expenses  clinical trials                                                                                                                                                                                                |  |               | 1,456    |   |                  |   | 960      |  
|Line of credit                                                                                                                                                                                                                    |  |               | 10,000   |   |                  |   | 7,500    |  
|Current portion of long-term liabilities                                                                                                                                                                                          |  |               | 521      |   |                  |   | 601      |  
|Current portion of obligation under capital lease                                                                                                                                                                                 |  |               | 86       |   |                  |   | 98       |  
|Other accrued expenses                                                                                                                                                                                                            |  |               | 13,148   |   |                  |   | 12,515   |  
|                                                                                                                                                                                                                                  |  |               |          |   |                  |   |          |  
|Total current liabilities                                                                                                                                                                                                         |  |               | 29,435   |   |                  |   | 29,031   |  
|Deferred rent                                                                                                                                                                                                                     |  |               | 228      |   |                  |   | 230      |  
|Deferred income                                                                                                                                                                                                                   |  |               | 3,264    |   |                  |   | 3,333    |  
|Obligation under capital leases                                                                                                                                                                                                   |  |               | 160      |   |                  |   | 177      |  
|Convertible notes                                                                                                                                                                                                                 |  |               | 40,474   |   |                  |   | 40,253   |  
|                                                                                                                                                                                                                                  |  |               |          |   |                  |   |          |  
|Total liabilities                                                                                                                                                                                                                 |  |               | 73,561   |   |                  |   | 73,024   |  
|Commitments and contingencies                                                                                                                                                                                                     |  |               |          |   |                  |   |          |  
|Stockholders deficit:                                                                                                                                                                                                            |  |               |          |   |                  |   |          |  
|Preferred stock, $0.001 par value; 5,000,000 shares authorized of which 1,000,000 shares have been designated as Series A Participating
Preferred Stock at March 31, 2008 and December 31, 2007; no shares issued and outstanding |  |               |         |   |                  |   |         |  
|Common stock, $0.001 par value; 100,000,000 shares authorized at March 31, 2008 and December 31, 2007; 33,029,326 and 32,911,887
shares issued and outstanding at March 31, 2008 and December 31, 2007, respectively              |  |               | 33       |   |                  |   | 33       |  
|Additional paid-in-capital                                                                                                                                                                                                        |  |               | 302,809  |   |                  |   | 301,857  |  
|Accumulated other comprehensive loss                                                                                                                                                                                              |  |               | (226     | ) |                  |   | (15      | )
|Accumulated deficit                                                                                                                                                                                                               |  |               | (316,138 | ) |                  |   | (303,183 | )
|                                                                                                                                                                                                                                  |  |               |          |   |                  |   |          |  
|Total stockholders deficit                                                                                                                                                                                                       |  |               | (13,522  | ) |                  |   | (1,308   | )
|                                                                                                                                                                                                                                  |  |               |          |   |                  |   |          |  
|Total liabilities and stockholders deficit                                                                                                                                                                                       |  | $             | 60,039   |   |                  | $ | 71,716   |  
|                                                                                                                                                                                                                                  |  |               |          |   |                  |   |          |  

See accompanying notes



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ISTA Pharmaceuticals, Inc.

Condensed Consolidated Statements of Operations

(In thousands, except per share amounts)

(unaudited)



|                                                                      |  |                             |         |   |      |   |         |  
|--------------------------------------------------------------------- |  | --------------------------- | ------- | - | ---- | - | ------- | -
|                                                                      |  | Three Months EndedMarch 31, |        
|                                                                      |  | 2008                        |         |   | 2007 |  
|Revenue:                                                              |  |                             |         |   |      |   |         |  
|Product sales, net                                                    |  | $                           | 15,454  |   |      | $ | 10,183  |  
|License revenue                                                       |  |                             | 69      |   |      |   | 69      |  
|                                                                      |  |                             |         |   |      |   |         |  
|Total revenue                                                         |  |                             | 15,523  |   |      |   | 10,252  |  
|Cost of products sold                                                 |  |                             | 4,189   |   |      |   | 2,533   |  
|                                                                      |  |                             |         |   |      |   |         |  
|Gross profit margin                                                   |  |                             | 11,334  |   |      |   | 7,719   |  
|Costs and expenses:                                                   |  |                             |         |   |      |   |         |  
|Research and development                                              |  |                             | 9,815   |   |      |   | 6,302   |  
|Selling, general and administrative                                   |  |                             | 13,650  |   |      |   | 12,341  |  
|                                                                      |  |                             |         |   |      |   |         |  
|Total costs and expenses                                              |  |                             | 23,465  |   |      |   | 18,643  |  
|                                                                      |  |                             |         |   |      |   |         |  
|Loss from operations                                                  |  |                             | (12,131 | ) |      |   | (10,924 | )
|Interest income                                                       |  |                             | 388     |   |      |   | 454     |  
|Interest expense                                                      |  |                             | (1,212  | ) |      |   | (981    | )
|                                                                      |  |                             |         |   |      |   |         |  
|Net loss                                                              |  | $                           | (12,955 | ) |      | $ | (11,451 | )
|                                                                      |  |                             |         |   |      |   |         |  
|Net loss per common share, basic and diluted                          |  | $                           | (0.39   | ) |      | $ | (0.44   | )
|                                                                      |  |                             |         |   |      |   |         |  
|Shares used in computing net loss per common share, basic and diluted |  |                             | 32,988  |   |      |   | 26,224  |  
|                                                                      |  |                             |         |   |      |   |         |  

See accompanying notes



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ISTA Pharmaceuticals, Inc.

Condensed Consolidated Statements of Cash Flows

(in thousands)

(unaudited)



|                                                                            |  |                             |         |   |      |   |         |  
|--------------------------------------------------------------------------- |  | --------------------------- | ------- | - | ---- | - | ------- | -
|                                                                            |  | Three Months EndedMarch 31, |        
|                                                                            |  | 2008                        |         |   | 2007 |  
|Operating Activities                                                        |  |                             |         |   |      |   |         |  
|Net loss                                                                    |  | $                           | (12,955 | ) |      | $ | (11,451 | )
|Adjustments to reconcile net loss to net cash used in operating activities: |  |                             |         |   |      |   |         |  
|Stock based compensation                                                    |  |                             | 898     |   |      |   | 827     |  
|Amortization of deferred financing costs                                    |  |                             | 142     |   |      |   | 139     |  
|Amortization of discount on convertible note                                |  |                             | 9       |   |      |   |        |  
|Change in value of derivatives related to convertible notes                 |  |                             | 212     |   |      |   |        |  
|Depreciation and amortization                                               |  |                             | 245     |   |      |   | 153     |  
|Changes in operating assets and liabilities:                                |  |                             |         |   |      |   |         |  
|Accounts receivable, net                                                    |  |                             | (1,022  | ) |      |   | 473     |  
|Inventory, net                                                              |  |                             | (80     | ) |      |   | (135    | )
|Other current assets                                                        |  |                             | (90     | ) |      |   | (325    | )
|Accounts payable                                                            |  |                             | (1,915  | ) |      |   | (956    | )
|Accrued compensation and related expenses                                   |  |                             | (1,218  | ) |      |   | (455    | )
|Accrued expenses  clinical trials and other accrued expenses               |  |                             | 1,129   |   |      |   | 65      |  
|Other liabilities                                                           |  |                             | (80     | ) |      |   | (61     | )
|Deferred rent                                                               |  |                             | (2      | ) |      |   | (4      | )
|Deferred income                                                             |  |                             | (69     | ) |      |   | (69     | )
|                                                                            |  |                             |         |   |      |   |         |  
|Net cash used in operating activities                                       |  |                             | (14,796 | ) |      |   | (11,799 | )
|                                                                            |  |                             |         |   |      |   |         |  
|Investing Activities                                                        |  |                             |         |   |      |   |         |  
|Maturities of marketable securities                                         |  |                             | 8,704   |   |      |   | 8,910   |  
|Purchases of equipment                                                      |  |                             | (368    | ) |      |   | (472    | )
|Restricted cash                                                             |  |                             | 800     |   |      |   | 800     |  
|Deposits and other assets                                                   |  |                             | 36      |   |      |   | (4      | )
|                                                                            |  |                             |         |   |      |   |         |  
|Net cash provided by investing activities                                   |  |                             | 9,172   |   |      |   | 9,234   |  
|                                                                            |  |                             |         |   |      |   |         |  
|Financing Activities                                                        |  |                             |         |   |      |   |         |  
|Proceeds from exercise of stock options                                     |  |                             | 6       |   |      |   | 137     |  
|Obligation under capital lease                                              |  |                             | (29     | ) |      |   | (10     | )
|Proceeds from line of credit                                                |  |                             | 10,000  |   |      |   | 6,500   |  
|Repayment on line of credit                                                 |  |                             | (7,500  | ) |      |   | (6,500  | )
|Proceeds from issuance of common stock, net of issuance costs               |  |                             | 48      |   |      |   | 53      |  
|                                                                            |  |                             |         |   |      |   |         |  
|Net cash provided by financing activities                                   |  |                             | 2,525   |   |      |   | 180     |  
|                                                                            |  |                             |         |   |      |   |         |  
|Decrease in Cash and Cash Equivalents                                       |  |                             | (3,099  | ) |      |   | (2,385  | )
|Cash and cash equivalents at beginning of period                            |  |                             | 25,500  |   |      |   | 17,236  |  
|                                                                            |  |                             |         |   |      |   |         |  
|Cash and Cash Equivalents At End of Period                                  |  | $                           | 22,401  |   |      | $ | 14,851  |  
|                                                                            |  |                             |         |   |      |   |         |  

See accompanying notes



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ISTA Pharmaceuticals, Inc.

Notes to Condensed Consolidated Financial Statements

(unaudited)

1. The Company

ISTA Pharmaceuticals, Inc. (ISTA or the Company) was incorporated in the
state of California on February 13, 1992 to discover, develop and market new remedies for diseases and conditions of the eye. The Company reincorporated in Delaware on August 4, 2000. Xibrom, Xibrom QD, Istalol®, Vitrase®, Bepreve, T-Pred, ISTA®, ISTA Pharmaceuticals,
Inc.® and the ISTA logo are the Companys trademarks, either owned or under license.

ISTA is an ophthalmic pharmaceutical company focused on the development and commercialization of products for serious diseases and conditions of the eye. Since the Companys inception, it has devoted its
resources primarily to fund research and development programs, late-stage product acquisitions and product commercial launches.

The
Company currently has three products available for sale in the U.S.: Xibrom (bromfenac sodium ophthalmic solution) for the treatment of inflammation and pain following cataract surgery, Istalol (timolol maleate ophthalmic solution) for the treatment
of glaucoma, and Vitrase (hyaluronidase for injection) for use as a spreading agent. The Company also has several product candidates in various stages of development.

2. Summary of Significant Accounting Policies

Basis of Presentation

The unaudited condensed consolidated financial statements of ISTA have been prepared in accordance with the instructions to Form 10-Q and Article 10 of
Regulation S-X. The accompanying consolidated financial statements do not include certain footnotes and financial presentations normally required under general accepted accounting principles (GAAP) and, therefore should be read in conjunction with
the consolidated financial statements and the notes thereto included in the Companys Annual Report on Form 10-K for the year ended December 31, 2007.

In the opinion of management, all adjustments (consisting of normal recurring adjustments) necessary for the fair presentation of the statement of financial condition and results of operations for the three month
periods ended March 31, 2008, and 2007 have been made. The interim results of operations are not necessarily indicative of the results to be expected for the full fiscal year.

Revenue Recognition

Product revenue.The Company recognizes revenue from product
sales, in accordance with Statement of Financial Accounting Standards, or SFAS, No. 48 Revenue Recognition When Right of Return Exists, when there is persuasive evidence that an arrangement exists, when title has passed, the price
is fixed or determinable, and the Company is reasonably assured of collecting the resulting receivable. The Company recognizes product revenue net of estimated allowances for discounts, returns, rebates and chargebacks. Such estimates require the
most subjective and complex judgment due to the need to make estimates about matters that are inherently uncertain. Actual results may differ significantly from the Companys estimates. Changes in estimates and assumptions based upon actual
results may have a material impact on the Companys results of operations and/or financial condition.

The Company establishes
allowances for estimated rebates, chargebacks and product returns based on numerous qualitative and quantitative factors, including:



| |  |  | The number of and specific contractual terms of agreements with customers;
| | - |  | --------------------------------------------------------------------------



| |  |  | Estimated level of units in the distribution channel;
| | - |  | -----------------------------------------------------



| |  |  | Historical rebates, chargebacks and returns of products;
| | - |  | --------------------------------------------------------



| |  |  | Direct communication with customers;
| | - |  | ------------------------------------



| |  |  | Anticipated introduction of competitive products or generics;
| | - |  | -------------------------------------------------------------



| |  |  | Anticipated pricing strategy changes by ISTA and/or its competitors;
| | - |  | --------------------------------------------------------------------



| |  |  | Analysis of prescription data gathered by a third-party prescription data provider;
| | - |  | -----------------------------------------------------------------------------------



| |  |  | The impact of changes in state and federal regulations; and
| | - |  | -----------------------------------------------------------



| |  |  | Estimated remaining shelf life of products.
| | - |  | -------------------------------------------

In its analyses, the Company utilizes on hand unit data purchased from the major wholesalers, as well as prescription data purchased from a third-party data provider to develop estimates of historical unit channel pull-through. The Company



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utilizes an internal analysis to compare historical net product shipments to estimated historical prescriptions written. Based on that analysis, it develops
an estimate of the quantity of product in the channel which may be subject to various rebate, chargeback and product return exposures.

Consistent with industry practice, the Company periodically offers promotional discounts to its existing customer base. These discounts are calculated as a percentage of the current published list price and the net price (i.e., the current
published list price less the applicable discount is invoiced to the customer). Accordingly, the discounts are recorded as a reduction of revenue in the period that the program is offered. In addition to promotional discounts, at the time that the
Company implements a price increase, the Company generally offers its existing customer base an opportunity to purchase a limited quantity of product at the previous list price. Shipments resulting from these programs generally are not in excess of
ordinary levels; therefore, the Company recognizes the related revenue upon receipt by the customer and includes the sale in estimating its various product-related allowances. In the event the Company determines that these sales represent purchases
of inventory in excess of ordinary levels for a given wholesaler, the potential impact on product returns exposure would be specifically evaluated and reflected as a reduction in revenue at the time of such sale.

Allowances for estimated rebates and chargebacks were $0.8 million and $0.7 million as of March 31, 2008 and 2007, respectively. These allowances
reflect an estimate of the Companys liability for items such as rebates due to various governmental organizations under the Medicare/Medicaid regulations, rebates due to managed care organizations under specific contracts and chargebacks due
to various organizations purchasing certain of our products through federal contracts and/or group purchasing agreements. The Company estimates its liability for rebates and chargebacks at each reporting period based on a combination of quantitative
and qualitative assumptions listed above.

Allowances for product returns were $2.0 million and $0.6 million as of March 31, 2008 and
2007, respectively. These allowances reflect an estimate of the Companys liability for product that may be returned by the original purchaser in accordance with the Companys stated return policy, which allows customers to return product
within six months of its expiry dating and for a period up to 12 months after it has reached the expiration date. The Company estimates its liability for product returns at each reporting period based on the estimated units in the channel and the
other factors discussed above.

For the three months ended March 31, 2008 compared to the three months ended March 31, 2007, the
Companys absolute exposure for rebates, chargebacks and product returns has increased as a result of increased sales of its existing products and the Company having additional historical sales data upon which to analyze these allowances.
Accordingly, reductions to revenue and corresponding increases to allowance accounts have likewise increased. The exposure to these revenue-reducing items as a percentage of gross product revenue for the three months ended March 31, 2008 and
2007 was 4.0% and 6.6%, respectively, for the allowance for rebates, chargebacks and discounts, and was 3.9% and 0.8%, respectively, for the allowance for product returns.

License revenue.The Company recognizes revenue consistent with the provisions of the Securities and Exchange Commissions, or SECs,
Staff Accounting Bulletin, or SAB, No. 104, Revenue Recognition, which sets forth guidelines in the timing of revenue recognition based upon factors such as passage of title, installation, payments and customer acceptance. Amounts
received for product and technology license fees under multiple-element arrangements are deferred and recognized over the period of such services or performance if such arrangements require on-going services or performance in accordance with
Emerging Issues Task Force, or EITF, Issue No. 00-21, Revenue Arrangements with Multiple Deliverables. Amounts received for milestones are recognized upon achievement of the milestone, unless the Company has ongoing performance
obligations. Royalty revenue is recognized upon sale of the related products, provided the royalty amounts are fixed and determinable and collection of the related receivable is reasonably assured. Any amounts received prior to satisfying the
Companys revenue recognition criteria are recorded as deferred revenue in the accompanying balance sheets.

Inventories

Inventory at March 31, 2008 consisted of $819,000 of raw materials and $2.3 million of finished goods, net of $707,000 in inventory reserves.
Inventory at December 31, 2007 consisted of $617,000 in raw materials and $2.1 million of finished goods, net of $396,000 in inventory reserves.

Inventory relates to Xibrom, a topical non-steroidal anti-inflammatory formulation of bromfenac for the treatment of ocular inflammation and pain following cataract surgery; Istalol, for the treatment of glaucoma;
Vitrase 200 USP units/ml for use as a spreading agent to facilitate the absorption and dispersion of other injected drugs; and Vitrase, lyophilized 6,200 USP units multi-purpose vial. Inventories, net of allowances, are stated at the lower of cost
or market. Cost is determined by the first-in, first-to-expire method.

Inventories are reviewed periodically for slow-moving or obsolete
status. The Company adjusts its inventory to reflect situations in which the cost of inventory is not expected to be recovered. The Company would record a reserve to adjust inventory to its net realizable value: (1) if a launch of a new product
is delayed, inventory may not be fully utilized and could be subject to impairment; (2) when a product is close to expiration and not expected to be sold; (3) when a product has



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reached its expiration date; or (4) when a product is not expected to be saleable. In determining the reserves for these products, the Company considers
factors such as the amount of inventory on hand and its remaining shelf life, and current and expected market conditions, including management forecasts and levels of competition. ISTA has evaluated the current level of inventory considering
historical trends and other factors, and based on its evaluation, has recorded adjustments to reflect inventory at its net realizable value. These adjustments are estimates, which could vary significantly from actual results if future economic
conditions, customer demand, competition or other relevant factors differ from expectations. These estimates require ISTA to make assessments about the future demand for its products in order to categorize the status of such inventory items as
slow-moving, obsolete or in excess-of-need. These future estimates are subject to the ongoing accuracy of managements forecasts of market conditions, industry trends, competition and other factors. If the Company over or under estimates the
amount of inventory that will not be sold prior to expiration, there may be a material impact on its consolidated financial condition and results of operations.

Costs incurred for the manufacture of validation batches for pre-approved products are recorded as research and development expense in the period in which those costs were incurred.

Restricted Cash

The Company has $1.6 million
of restricted cash at March 31, 2008, which supports a letter of credit issued as security for interest payments on the outstanding senior subordinated convertible notes.

Fair Value Measurements

Effective January 1, 2008, the Company adopted SFAS
No. 157, Fair Value Measurements, or SFAS 157, which defines fair value as the exchange price that would be received for an asset or paid to transfer a liability (an exit price) in the principal or most advantageous market for the
asset or liability in an orderly transaction between market participants at the measurement date. SFAS 157 establishes a three-level fair value hierarchy that prioritizes the inputs used to measure fair value. This hierarchy requires entities
to maximize the use of observable inputs and minimize the use of unobservable inputs. The three levels of inputs used to measure fair value are as follows:



| |  |  | Level 1  Quoted prices in active markets for identical assets or liabilities.
| | - |  | ------------------------------------------------------------------------------



| |  |  | Level 2  Observable inputs other than quoted prices included in Level 1, such as quoted prices for similar assets and liabilities in active
markets; quoted prices for identical or similar assets and liabilities in markets that are not active; or other inputs that are observable or can be corroborated by observable market data.
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | Level 3  Unobservable inputs that are supported by little or no market activity and that are significant to the fair value of the assets or
liabilities. This includes certain pricing models, discounted cash flow methodologies and similar techniques that use significant unobservable inputs.
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

The Companys adoption of SFAS 157 did not have a material impact on its consolidated financial statements. The Company has segregated all financial assets and liabilities at fair value on a recurring basis (at
least annually) into the most appropriate level within the fair value hierarchy based on the inputs used to determine the fair value at the measurement date in the table below. FASB Staff Position (FSP FAS 157-2Effective Date of FASB Statement
No. 157), or FSP FAS 157-2, delayed the effective date for all nonfinancial assets and liabilities until January 1, 2009, except those that are recognized or disclosed at fair value in the financial statements on a recurring basis.

Effective January 1, 2008, the Company adopted SFAS No. 159, The Fair Value Option for Financial Assets and Financial
LiabilitiesIncluding an amendment of FASB Statement No. 115, or SFAS 159, which provides entities the option to measure many financial instruments and certain other items at fair value. Entities that choose the fair value option will
recognize unrealized gains and losses on items for which the fair value option was elected in earnings at each subsequent reporting date. The Company has currently chosen not to elect the fair value option for any items that are not already required
to be measured at fair value in accordance with GAAP.

Assets and liabilities measured at fair value on a recurring basis are summarized
below (in thousands):



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##### Table of Contents

|                                                       |  |                                                  |        |                                             |   |                                         |  |   |                                     |   |  |   |        |  
|------------------------------------------------------ |  | ------------------------------------------------ | ------ | ------------------------------------------- | - | --------------------------------------- |  | - | ----------------------------------- | - |  | - | ------ | -
|                                                       |  | Fair Value Measurements at March 31, 2008 Using: |        |                                             |   |                                        
|(in thousands)                                         |  | Quoted Prices inActive Markets(Level 1)          |        | Significant OtherObservableInputs (Level 2) |   | SignificantUnobservableInputs (Level 3) |  |   | Total CarryingValue atMarch 31,2008 |  
|Cash and cash equivalents (including restricted cash)  |  | $                                                | 24,001 |                                             | $ |                                        |  | $ |                                    |   |  | $ | 24,001 |  
|Short-term investments  available for sale securities |  |                                                  | 7,227  |                                             |   |                                        |  |   |                                    |   |  |   | 7,227  |  
|Available for sale securities  long term              |  |                                                  |       |                                             |   |                                        |  |   | 4,498                               |   |  |   | 4,498  |  
|Derivatives                                            |  |                                                  |       |                                             |   |                                        |  |   | (592                                | ) |  |   | (592   | )



|                                               |  |                                                                                                    |       |  
|---------------------------------------------- |  | -------------------------------------------------------------------------------------------------- | ----- | -
|                                               |  | Fair Value MeasurementsUsing SignificantUnobservable Inputs(Level 3) Auction RateSecurities        |      
|Beginning balance at December 31, 2007         |  | $                                                                                                  |      |  
|Total gains or losses (realized or unrealized) |  |                                                                                                    |      |  
|Included in earnings                           |  |                                                                                                    |       |  
|Included in other comprehensive income         |  |                                                                                                    | (202  | )
|Purchases, issuances, and settlements          |  |                                                                                                    | 4,700 |  
|Transfers in and/or out of Level 3             |  |                                                                                                    |      |  
|                                               |  |                                                                                                    |       |  
|Ending balance at March 31, 2008               |  | $                                                                                                  | 4,498 |  
|                                               |  |                                                                                                    |       |  
|                                               | 
|                                               |  | Fair Value MeasurementsUsing SignificantUnobservable Inputs(Level 3) Derivative onConvertible Note |      
|Beginning balance at December 31, 2007         |  | $                                                                                                  | (380  | )
|Total gains or losses (realized or unrealized) |  |                                                                                                    |       |  
|Included in earnings                           |  |                                                                                                    | (212  | )
|Included in other comprehensive income         |  |                                                                                                    |      |  
|Purchases, issuances, and settlements          |  |                                                                                                    |      |  
|Transfers in and/or of Level 3                 |  |                                                                                                    |      |  
|                                               |  |                                                                                                    |       |  
|Ending balance at March 31, 2008               |  | $                                                                                                  | (592  | )
|                                               |  |                                                                                                    |       |  

Available for Sale Securities  Short and Long Term

Available for sale securities consist primarily of certificates of deposit, corporate bonds, commercial paper, U.S. Treasury securities and agency bonds,
and auction rate securities (ARS). ARS are long-term variable rate bonds tied to short-term interest rates that are reset through a Dutch auction process which primarily occur every 7 to 35 days.



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##### Table of Contents

Available for sale securities at fair value, which approximates unamortized cost, consist of the
following:



|                                          |  |               |        |                  |   |       
|----------------------------------------- |  | ------------- | ------ | ---------------- | - | ------
|                                          |  | March 31,2008 |        | December 31,2007
|Commercial Paper                          |  | $             | 4,525  |                  | $ | 7,042 
|Corporate Bonds                           |  |               |       |                  |   | 3,247 
|Certificates of Deposit                   |  |               | 700    |                  |   | 601   
|Auction Rate Securities                   |  |               | 4,498  |                  |   | 9,750 
|U.S. Treasury securities and agency bonds |  |               | 2,002  |                  |   |      
|                                          |  |               |        |                  |   |       
|Total                                     |  | $             | 11,725 |                  | $ | 20,640
|                                          |  |               |        |                  |   |       

Despite the underlying long-term contractual maturity of ARS, there has generally been a
ready liquid market for these securities based on the interest reset mechanism. Historically, these securities were classified as current assets due to the Companys intent and ability to sell these securities as necessary to meet current
liquidity needs. However, as a result of current negative liquidity and uncertainty in financial credit markets, the Company has experienced failed auctions associated with certain of its remaining ARS. In the case of a failed
auction, the ARS become illiquid long-term bonds (until a future auction is successful or the security is called prior to the contractual maturity date by the issuer) and the rates are reset in accordance with terms in the prospectus/offering
circular. The remaining ARS as of March 31, 2008 consist primarily of fully insured, AAA rated government guaranteed under the Federal Family Education Loan Program, or FFELP, student loan-backed securities. Due to the aforementioned
uncertainties, all of the Companys auction rate securities were classified as long-term investments in the condensed consolidated balance sheet as of March 31, 2008.

In determining the fair value of the Companys available-for-sale auction rate securities at March 31, 2008, it has taken into consideration fair values determined by the financial institutions, current
credit rating of the securities, discounted cash flow analysis, as deemed appropriate, and its current liquidity position. The amount of unrealized losses related to the temporary impairment of the ARS was $0.2 million for the three months
ended March 31, 2008.

Comprehensive Income (Loss)

Statement of Financial Accounting Standard No. 130, Reporting Comprehensive Income, or SFAS 130, requires reporting and displaying comprehensive income (loss) and its components, which, for ISTA,
includes net loss and unrealized gains and losses on investments and foreign currency translation gains and losses. Total comprehensive loss for the three months ended March 31, 2008 and 2007 was $13.2 million and $11.5 million, respectively.
In accordance with SFAS 130, the accumulated balance of unrealized gains (losses) on investments and the accumulated balance of foreign currency translation adjustments are disclosed as separate components of stockholders deficit.

As of March 31, 2008 and December 31, 2007, accumulated foreign currency translation adjustments were ($25,000) and ($25,000),
respectively, and accumulated unrealized gains (losses) on investments were ($201,000) and $10,000, at March 31, 2008 and December 31, 2007, respectively.

Stock-Based Compensation

On January 1, 2006, the Company adopted SFAS No. 123
(revised 2004), Share-Based Payment, or SFAS 123(R), which requires measurement and recognition of compensation expense for all share-based awards made to employees and directors. Under SFAS 123R, the fair value of share-based
awards is estimated at grant date using an option pricing model, and the portion that is ultimately expected to vest is recognized as compensation cost over the requisite service period.

Since share-based compensation under SFAS 123R is recognized only for those awards that are ultimately expected to vest, the Company has applied an
estimated forfeiture rate to unvested awards for the purpose of calculating compensation cost. These estimates will be revised, if necessary, in future periods if actual forfeitures differ from estimates. Changes in forfeiture estimates impact
compensation cost in the period in which the change in estimate occurs.

The Company uses the Black-Scholes option-pricing model to
estimate the fair value of share-based awards. The determination of fair value using the Black-Scholes option-pricing model is affected by the Companys stock price as well as assumptions regarding a number of complex and subjective variables,
including expected stock price volatility, risk-free interest rate, expected dividends and projected employee stock option exercise behaviors. Beginning January 1, 2008, the simplified method was no longer permitted and the Company estimated
the expected term based on the contractual term of the awards and employees exercise and expected post-vesting termination behavior. The impact of this transition did not have a significant impact on the valuation of the Companys stock
options.

At March 31, 2008, there was $8.9 million of total unrecognized compensation cost related to non-vested stock options, which
is expected to be recognized over a remaining weighted average vesting period of 2 years.



8



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##### Table of Contents

Restricted Stock Awards

During the three months ended March 31, 2008 the Company granted a total of 121,205 shares of restricted common stock to employees under the Companys 2004 Performance Incentive Plan, as amended.
Restrictions on these shares will expire and related charges are being amortized as earned over the vesting period of four years.

The
amount of compensation to be recognized is based on the market value of the shares on the date of issuance. Expenses related to the vesting of restricted stock (charged to selling, general and administrative expenses) were $133,000 and $58,000 for
the three months ended March 31, 2008 and March 31, 2007, respectively. As of March 31, 2008, there was approximately $1.6 million of unamortized compensation cost related to restricted stock awards, which is expected to be
recognized ratably over the vesting period of four years.

Net Loss Per Share

In accordance with SFAS No. 128, Earnings Per Share, or SFAS 128, and SEC SAB No. 98, or SAB 98, basic net loss per common share is
computed by dividing the net loss for the period by the weighted average number of common shares outstanding during the period. Under SFAS 128, diluted net income (loss) per share is computed by dividing the net income (loss) for the period by the
weighted-average number of common and common equivalent shares, such as stock options, outstanding during the period. Such common equivalent shares have not been included in the Companys computation of diluted net loss per share as their
effect would be anti-dilutive. The total number of shares excluded from the calculation of diluted net loss per share, prior to application of the treasury stock method for options, warrants, and as-converted shares was 11,175,877 and 11,110,607 for
the three months ended March 31, 2008 and 2007, respectively.

Under the provisions of SAB 98, common shares issued for nominal
consideration, if any, would be included in the per share calculations as if they were outstanding for all periods presented.

Executive Employment
Agreements

The Company has agreements with each of its officers which provides that any unvested stock options and restricted
shares then held by such officer will become fully vested and, with respect to stock options, immediately exercisable, in the event of a change in control of the Company and, in certain instances, if within twenty-four months following such change
in control such officers employment is terminated by the Company without cause or such officer resigns for good reason within sixty days of the event forming the basis for such good reason termination.

Equity Financing

In June 2007, the Company
entered into definitive agreements with institutional accredited investors with respect to the private placement of 5.25 million shares of its common stock at a purchase price of $7.00 per share, resulting in gross proceeds of approximately
$36.75 million before payment of placement agent fees and offering expenses.

Convertible Notes

The Company issued $40 million in convertible notes in June 2006 which provide, among other things, that if there is a change in control of the Company,
as defined, during the term of the convertible notes (maturing in June 2011) the holders of the notes will be entitled to receive a cash payment equal to 115% of the principal amount of the notes, plus accrued but unpaid interest, or a formula based
on the Companys stock price on certain specified dates. Since the settlement is indexed to the Companys stock, the settlement feature is a derivative that is required to be bifurcated from the host debt instrument and recorded at fair
value at each quarter end. Changes in fair value of the derivative are recorded as interest expense and the difference between the face value of the convertible notes and the amount remaining after the bifurcation is recorded as a discount to be
amortized over the term of the notes, which is five years.

The derivative liability as of March 31, 2008 and 2007 is $0.6 million and
$0.2 million, respectively, and is classified with the host debt instrument in convertible notes in the condensed consolidated balance sheet. The embedded derivative is marked-to-market through earnings on a quarterly basis. The net effect of the
changes in the value of the derivative ($212,000 at March 31, 2008) and the amortization of the related debt discount ($9,000 at March 31, 2008) was not significant in 2008 and 2007.

Commitments and Contingencies

The Company is
subject to routine claims and litigation incidental to its business. In the opinion of management, the resolution of such claims is not expected to have a material adverse effect on the operating results, cash flows or financial position of the
Company.



9



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##### Table of Contents

Segment Reporting

The Company currently operates in only one segment.

Income Taxes

At December 31, 2007, the Company had federal and state tax net operating loss, or NOL, carryforwards of approximately $175.1 million and $96.3
million, respectively, which will begin to expire in 2008 and 2007 respectively, unless previously utilized. The Company also had federal and state research and development, or R&D, credit carryforwards of $7.3 million and $4.5 million,
respectively. The federal R&D tax credits will begin to expire in 2008, unless previously utilized. The Companys California research tax credit carryforwards do not expire and will carry forward indefinitely until utilized.

Because realization of such tax benefits is uncertain, the Company has provided a 100% valuation allowance as of December 31, 2007 and
March 31, 2008. Pursuant to Sections 382 and 383 of the Internal Revenue Code of 1986, as well as similar state and foreign provisions, utilization of the NOL and R&D credit carryforwards may be subject to a substantial annual limitation
due to ownership change limitations that might have occurred previously or that could occur in the future. Due to the significant complexity and cost, the Company has not completed a study to assess whether a change in control has occurred or
whether there have been multiple changes of control since the Companys formation. Further, until a study is completed and any limitation known, no amounts are being presented as an uncertain tax position under FASB Interpretation No. 48,
Accounting for Uncertainty in Income Taxes  An Interpretation of FASB Statement No. 109, or FIN 48. There have been no significant changes during the three months ended March 31, 2008 for any uncertain tax positions and
the Company does not expect its unrecognized tax benefits to change significantly over the next 12 months. There were no accrued interest and penalties associated with uncertain tax positions as of December 31, 2007 or March 31, 2008.
Interest and penalties related to uncertain tax positions will be reflected in income tax expense. Tax years 1992 to 2007 remain subject to future examination by the major tax jurisdictions in which the Company is subject to tax.

Recent Accounting Pronouncements

In February
2007, the FASB issued SFAS 159. SFAS 159 permits entities to elect to measure many financial instruments and certain other items at fair value. Unrealized gains and losses on items for which the fair value option has been elected will be recognized
in earnings at each subsequent reporting date. SFAS 159 was effective for the Company on January 1, 2008. The adoption of SFAS 159 did not have a material impact on the Companys consolidated financial statements.

In September 2006, the FASB issued SFAS 157, which defines fair value, establishes a framework for measuring fair value and expands disclosure
requirements about fair value measurements. SFAS 157 was effective for the Company on January 1, 2008. However, in February 2008, the FASB released FSP FAS 157-2, which delayed the effective date of SFAS 157 for all nonfinancial assets and
nonfinancial liabilities, except those that are recognized or disclosed at fair value in the financial statements on a recurring basis (at least annually). The adoption of SFAS 157 for the Companys financial assets and liabilities did not have
a material impact on its consolidated financial statements. The Company does not believe the adoption of SFAS 157 for its non-financial assets and liabilities, effective January 1, 2009, will have a material impact on its consolidated financial
statements.

New Accounting Standard Not Yet Adopted

In November 2007, the Emerging Issues Task Force, or EITF, issued EITF Issue 07-01 Accounting for Collaborative Arrangements, or EITF 07-01. EITF 07-01 requires collaborators to present the results of
activities for which they act as the principal on a gross basis and report any payments received from (made to) other collaborators based on other applicable GAAP or, in the absence of other applicable GAAP, based on analogy to authoritative
accounting literature or a reasonable, rational, and consistently applied accounting policy election. Further, EITF 07-01 clarified that the determination of whether transactions within a collaborative arrangement are part of a vendor-customer (or
analogous) relationship subject to EITF Issue 01-9, Accounting for Consideration Given by a Vendor to a Customer. EITF 07-01 is effective for fiscal years beginning after December 15, 2008. The Company has not yet completed its
evaluation of EITF 07-01, but does not currently believe that it will have a material impact on the results of operations, financial position or cash flows of the Company.

On December 4, 2007, the FASB issued SFAS No. 141 (Revised 2007), Business Combinations, or SFAS 141R. Under SFAS 141R,
an acquiring entity will be required to recognize all the assets acquired and liabilities assumed in a



10



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##### Table of Contents

transaction at the acquisition date fair value with limited exceptions. SFAS 141R will change the accounting treatment for certain specific items,
including:



| |  |  | acquisition costs will be generally expensed as incurred;
| | - |  | ---------------------------------------------------------



| |  |  | noncontrolling interests will be valued at fair value at the acquisition date;
| | - |  | ------------------------------------------------------------------------------



| |  |  | acquired contingent liabilities will be recorded at fair value at the acquisition date and subsequently measured at either the higher of such amount or the amount
determined under existing guidance for non-acquired contingencies;
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | in-process research and development will be recorded at fair value as an indefinite-lived intangible asset at the acquisition date until the completion or
abandonment of the associated research and development efforts;
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | restructuring costs associated with a business combination will be generally expensed subsequent to the acquisition date; and
| | - |  | -----------------------------------------------------------------------------------------------------------------------------



| |  |  | changes in deferred tax asset valuation allowances and income tax uncertainties after the acquisition date generally will affect income tax expense.
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------

SFAS 141R also includes a substantial number of new disclosure requirements. SFAS 141R applies prospectively
to business combinations for which the acquisition date is on or after the beginning of the first annual reporting period beginning on or after December 15, 2008. Earlier adoption is prohibited. The Company is currently assessing the impact of
this statement but believes it will not have a material impact on its consolidated financial position, results of operations, or cash flows upon adoption.

On December 4, 2007, the FASB issued SFAS No. 160, Noncontrolling Interests in Consolidated Financial Statements  An Amendment of ARB No. 51, or SFAS 160. SFAS 160
establishes new accounting and reporting standards for the noncontrolling interest in a subsidiary and for the deconsolidation of a subsidiary. Specifically, this statement requires the recognition of a noncontrolling interest (minority interest) as
equity in the consolidated financial statements and separate from the parents equity. The amount of net income attributable to the noncontrolling interest will be included in consolidated net income on the face of the income statement.
SFAS 160 clarifies that changes in a parents ownership interest in a subsidiary that do not result in deconsolidation are equity transactions if the parent retains its controlling financial interest. In addition, this statement requires
that a parent recognize a gain or loss in net income when a subsidiary is deconsolidated. Such gain or loss will be measured using the fair value of the noncontrolling equity investment on the deconsolidation date. SFAS 160 also includes
expanded disclosure requirements regarding the interests of the parent and its noncontrolling interest. SFAS 160 is effective for fiscal years, and interim periods within those fiscal years, beginning on or after December 15, 2008. Earlier
adoption is prohibited. The Company is currently assessing the impact of this statement, but believes it will not have a material impact on its consolidated financial position, results of operations, or cash flows upon adoption.



|Item 2 | Managements Discussion and Analysis of Financial Condition and Results of Operations
|------ | -------------------------------------------------------------------------------------

This Quarterly Report on Form 10-Q contains forward-looking statements that have been made pursuant to the provisions of the Private Securities Litigation
Reform Act of 1995 and concern matters that involve risks and uncertainties that could cause actual results to differ materially from those projected in the forward-looking statements. Discussions containing forward-looking statements may be found
in the material set forth under Managements Discussion and Analysis of Financial Condition and Results of Operations, Risk Factors and other sections of this Quarterly Report on Form 10-Q. Words such as may,
will, should, could, expect, plan, anticipate, believe, estimate, predict, potential, continue or similar words are
intended to identify forward-looking statements, although not all forward-looking statements contain these words. Although we believe that our opinions and expectations reflected in the forward-looking statements are reasonable as of the date of
this Quarterly Report on Form 10-Q, we cannot guarantee future results, levels of activity, performance or achievements, and our actual results may differ substantially from the views and expectations set forth in this Quarterly Report on Form 10-Q.
We expressly disclaim any intent or obligation to update any forward-looking statements after the date hereof to conform such statements to actual results or to changes in our opinions or expectations. Readers are urged to carefully review and
consider the various disclosures made by us, which attempt to advise interested parties of the risks, uncertainties, and other factors that affect our business, including without limitation the disclosures made under the captions
Managements Discussion and Analysis of Financial Condition and Results of Operations and Risk Factors in this Quarterly Report on Form 10-Q and the audited financial statements and the notes thereto and disclosures made
under the captions Management Discussion and Analysis of Financial Condition and Results of Operations, Risk Factors, Consolidated Financial Statements and Notes to Consolidated Financial Statements
included in our Annual Report on Form 10-K for the year ended December 31, 2007. We obtained the market data and industry information contained in this Quarterly Report on Form 10-Q from internal surveys, estimates, reports and studies, as
appropriate, as well as from market research, publicly available information and industry publications. Although we believe our internal surveys, estimates, reports, studies and market research, as well as industry publications, are reliable, we
have not independently verified such information, and, as such, we do not make any representation as to its accuracy.



11



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##### Table of Contents

Overview

We are an ophthalmic pharmaceutical company. Our products and product candidates address the $4.7
billion U.S. prescription ophthalmic market and include therapies for inflammation, ocular pain, glaucoma, allergy, dry eye, vitreous hemorrhage, and diabetic retinopathy. We currently have three products for sale in the U.S.: Xibrom
(bromfenac sodium ophthalmic solution) for the treatment of inflammation and pain following cataract surgery, Istalol® (timolol maleate ophthalmic solution) for the treatment of glaucoma,
and Vitrase® (hyaluronidase for injection) for use as a spreading agent. We also have several product candidates in various stages of development. We have incurred losses since inception
and had an accumulated deficit of $316.1 million through March 31, 2008.

Results of Operations

Three Months Ended March 31, 2008 and 2007

Revenue. Product sales were approximately $15.5 million for the three months ended March 31, 2008, as compared to $10.2 million for the three months ended March 31, 2007. The increase in revenue was primarily attributable
to the continued growth of Xibrom and Istalol in the marketplace.

In addition to product revenues for the three months ended
March 31, 2008 and 2007, we recorded license revenue of $69,000 in each of the three months ended March 31, 2008 and 2007, reflecting the amortization of deferred revenue recorded in December 2001 for the license fee payment made by Otsuka
Pharmaceuticals Co., Ltd. in connection with the license of Vitrase in Japan for ophthalmic uses in the posterior region of the eye.

The
following table sets forth our net revenue for each of our products for each of the three month periods ended March 31, 2008 and 2007 and the corresponding percentage change.

Net Revenue



|                  |  |                             |      |                             |   |          |  |     |  
|----------------- |  | --------------------------- | ---- | --------------------------- | - | -------- |  | --- | -
|$ millions        |  | Quarter EndedMarch 31, 2008 |      | Quarter EndedMarch 31, 2007 |   | % Change | 
|Xibrom            |  | $                           | 11.8 |                             | $ | 7.0      |  | 69  | %
|Istalol           |  |                             | 2.7  |                             |   | 2.2      |  | 23  | %
|Vitrase           |  |                             | 0.9  |                             |   | 1.0      |  | -10 | %
|Other             |  |                             | 0.1  |                             |   | 0.1      |  | 0   | %
|                  |  |                             |      |                             |   |          |  |     |  
|Total Net Revenue |  | $                           | 15.5 |                             | $ | 10.3     |  | 51  | %
|                  |  |                             |      |                             |   |          |  |     |  

Gross margin and cost of products sold. Gross margin for the three months ended
March 31, 2008 was 73% of net revenue, or $11.3 million, as compared to 75% of net revenue, or $7.7 million, for the three months ended March 31, 2007. The change in gross margin as a percentage of net revenue is primarily due to an
increase in royalty rate for Xibrom and other costs.

Cost of products sold was $4.2 million for the three months ended March 31,
2008, as compared to $2.5 million for the three months ended March 31, 2007. Cost of products sold for the three months ended March 31, 2008 and 2007 consisted primarily of standard costs for each of our commercial products, distribution
costs, royalties, and other costs of products sold. The increase in cost of products sold is primarily the result of increased net product sales year over year.

We expect our gross margin for 2008 will be approximately 70% to 73%, subject to quarterly fluctuations based on revenue mix.

Research and development expenses. Research and development expenses were $9.8 million for the three months ended March 31, 2008, as compared to $6.3 million for the three months ended March 31, 2007.
The increase in research and development expenses for the first quarter of 2008 was primarily the result of an increase in clinical development costs, which include clinical investigator fees, study monitoring costs and data management costs, due to
the completion of the Xibrom QD once-daily Phase III studies, Bepreve Phase III studies and other studies. Additionally, there was $0.2 million of stock-based compensation expense included in research and development expenses for the three months
ended March 31, 2008 as compared to no stock-based compensation expense included in research and development expenses for the three months ended March 31, 2007. Our research and development expenses to date have consisted primarily of
costs associated with the clinical trials of our product candidates, compensation and other expenses for research and development personnel, costs for consultants and contract research organizations and costs related to the development of commercial
scale manufacturing capabilities for Vitrase, Istalol and Xibrom.

Generally, our research and development resources are not dedicated to a
single project but are applied to multiple product candidates in our portfolio. As a result, we manage and evaluate our research and development expenditures



12



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##### Table of Contents

generally by the type of costs incurred. We generally classify and separate research and development expenditures into amounts related to clinical
development costs, regulatory costs, pharmaceutical development costs, manufacturing development costs, and medical affairs costs. In addition, we also record as research and development expenses any up front and milestone payments that have accrued
to third parties prior to regulatory approval of a product candidate under our licensing agreements unless there is an alternative future use. For the three months ended March 31, 2008, approximately 70% of our research and development
expenditures were for clinical development costs, 2% were for regulatory costs, 4% were for pharmaceutical development costs, 15% were for manufacturing development costs, 8% were for medical affairs costs and 1% for stock-based compensation
expense.

Changes in our research and development expenses are primarily due to the following:



| |  |  | Clinical Development Costs  Overall clinical costs, which include clinical investigator fees, study monitoring costs and data management, for the three months
ended March 31, 2008 were $6.8 million as compared to $3.5 million for the three months ended March 31, 2007 or an increase of $3.3 million. The increase in clinical costs in 2008 was primarily due to costs associated with the Xibrom QD
clinical trial, the Bepreve Phase III clinical trials and other study costs.
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | Regulatory Costs  Regulatory costs, which include compliance expense for existing products and other activity for pipeline projects, were $0.2 million for the
three months ended March 31, 2008 as compared to $0.8 million for the three months ended March 31, 2007. The decrease of $600,000 was due primarily to an overall increase in outside consulting costs offset by a receivable recorded at March
31, 2008 in the amount of $0.9 million representing a partial refund of our NDA filing fee paid in December 2007 for Xibrom QD. The receivable was subsequently collected.
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | Pharmaceutical Development Costs  Pharmaceutical development costs, which include costs related to the testing and development of our pipeline products, for
the three months ended March 31, 2008 were $0.4 million as compared to $0.3 million for the three months ended March 31, 2007 or an increase of $100,000. The increase is primarily due to the overall increase in outside research expenses.
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | Manufacturing Development Costs  Manufacturing development costs, which include costs related to production scale-up and validation, raw material
qualification, and stability studies, for the three months ended March 31, 2008 were $1.5 million as compared to $1.1 million for the three months ended March 31, 2007 or an increase of $400,000. The increase is primarily attributable to
an overall increase in research related costs such as clinical supplies and stability studies associated with our growing pipeline of products.
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | Medical Affairs Costs  Medical affairs costs, which include activities that relate to medical information in support of our products, for the three months
ended March 31, 2008 were $0.8 million as compared to $0.6 million for the three months ended March 31, 2007, or an increase of $200,000. The increase is primarily attributable to an overall increase in outside consulting and investigator
costs.
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Our research and development activities reflect our efforts to advance our product candidates through the various
stages of product development. The expenditures that will be necessary to execute our development plans are subject to numerous uncertainties, which may affect our research and development expenditures and capital resources. For instance, the
duration and the cost of clinical trials may vary significantly depending on a variety of factors including a trials protocol, the number of patients in the trial, the duration of patient follow-up, the number of clinical sites in the trial,
and the length of time required enrolling suitable patient subjects. Even if earlier results are positive, we may obtain different results in later stages of development, including failure to show the desired safety or efficacy, which could impact
our development expenditures for a particular product candidate. Although we spend a considerable amount of time planning our development activities, we may be required to alter from our plan based on new circumstances or events or our assessment
from time to time of a product candidates market potential, other product opportunities and our corporate priorities. Any deviation from our plan may require us to incur additional expenditures or accelerate or delay the timing of our
development spending. Furthermore, as we obtain results from trials and review the path toward regulatory approval, we may elect to discontinue development of certain product candidates in certain indications, in order to focus our resources on more
promising candidates or indications. As a result, the amount or ranges of estimable cost and timing to complete our product development programs and each future product development program is not estimable.

Depending upon the progress of our clinical and pre-clinical programs, we expect our research and development expenses in 2008 will be approximately $34
to $38 million, including stock-based compensation expense, which we estimate to be approximately $1.5 to $2.5 million.

Selling,
general and administrative expenses. Selling, general and administrative expenses were $13.7 million for the three months ended March 31, 2008, as compared to $12.3 million for the three months ended March 31, 2007. The $1.4 million
increase in selling, general and administrative expenses in 2008 as compared to 2007 primarily results from higher sales and marketing expenses associated with the expansion of our sales force ($0.9 million), an overall increase in administrative
costs related to expanding our operations and other general corporate expenses, such as facility and personnel costs ($0.6 million), offset by a decrease in compensation expense ($0.1 million) due to the allocation of a portion of



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compensation expense to research and development expense. Selling, general, and administrative expenses during the first quarter of 2008 includes $0.7
million in stock-based compensation expense.

We anticipate our selling, general and administrative expenses for 2008 will be approximately
$50 to $54 million, including stock-based compensation expense which we estimate will be approximately $2.5 to $3.5 million.

Stock-based compensation. Compensation for stock options granted to non-employees has been determined in accordance with SFAS No. 123(R), Share-Based Payment, or SFAS 123R, and EITF Consensus No. 96-18,
Accounting for Equity Instruments that are Issued to Other Than Employees for Acquiring or in Conjunction with Selling Goods or Services. Stock option compensation for non-employees is recorded as the related services are rendered and
the value of compensation is periodically re-measured as the underlying options vest.

For the three months ended March 31, 2008 and
2007, we granted stock options to employees to purchase 823,447 shares of common stock (at a weighted average exercise price of $4.61 per share) and 909,829 shares of common stock (at a weighted average exercise price of $7.59 per share),
respectively, equal to the fair market value of our common stock at the time of grant. We also issued 121,205 restricted stock awards and 101,291 restricted stock awards for the three months ended March 31, 2008 and 2007, respectively, and
included in stock compensation expense was $133,000 and $58,000 for the three months ended March 31, 2008 and 2007, respectively, related to these restricted stock awards.

Interest income. Interest income was $0.4 million for the three months ended March 31, 2008, as compared to $0.5 million for the three months
ended March 31, 2007. The decrease in interest income was primarily attributable to lower rates of return on cash balances for the quarter ended March 31, 2008 as compared to the quarter ended March 31, 2007.

Interest expense. Interest expense was $1.2 million for the three months ended March 31, 2008, as compared to $1.0 million for the three
months ended March 31, 2007. The increase in interest expense was primarily attributable to the interest on the outstanding amounts under our credit facility, the amortization of the deferred financing costs associated with the issuance of
$40.0 million in senior subordinated convertible notes, the interest recorded on these outstanding senior subordinated convertible notes and the mark-to-market adjustment on the derivative associated with the subordinated convertible notes.

Liquidity and Capital Resources

As of
March 31, 2008, we had approximately $29.6 million in cash, cash equivalents and short-term investments, $1.6 million of restricted cash, which supports a letter of credit issued as security for interest payments on the outstanding senior
subordinated convertible notes, $4.5 million in long term investments and working capital of $16.1 million. Historically, we have financed our operations primarily through sales of our debt and equity securities. Since March 2000, we have received
gross proceeds of approximately $281.7 million from sales of our common stock and the issuance of promissory notes and convertible debt.

Under our revolving credit facility, we may borrow up to the lesser of $10.0 million or 66.67% of our unrestricted cash, cash equivalents and net receivables. As of March 31, 2008, we had no available borrowings under the credit
facility. All outstanding amounts under the credit facility bear interest at a variable rate equal to the lenders prime rate plus 0.5%, which is payable on a monthly basis. The credit facility also contains customary covenants regarding
operations of our business and financial covenants relating to ratios of current assets to current liabilities and is collateralized by all of our assets with the exception of our intellectual property. As of March 31, 2008, we were in
compliance with all of the covenants under the credit facility. All amounts owing under the credit facility will become due and payable on March 31, 2009.

In April 2006, we entered into a credit arrangement whereby we may borrow up to $1.2 million to finance the purchase of certain capital equipment. The outstanding amounts under this arrangement will become due and
payable ratably over three years from the purchase date of the equipment. As of March 31, 2008, $0.5 million was outstanding under this arrangement.

Additionally, in June 2006, we issued an aggregate of $40.0 million in principal amount of our senior subordinated convertible notes, bearing 8% interest per annum payable quarterly in cash in arrears which began
October 1, 2006. The notes mature in June 2011 and are convertible, at the option of the holders of the notes, into shares of our common stock at a conversion price of $7.63 per share, subject to certain adjustments set forth therein.

For the three months ended March 31, 2008, we used $14.8 million of cash for operations principally as a result of the net loss of
$13.0 million, the net change in operating assets and liabilities of ($3.1) million, offset by the recording of $0.9 million in stock based compensation, the recording of $0.2 million in depreciation and amortization and the recording of $0.2
million for the change in the value of the derivative associated with the subordinated convertible notes. For the three months ended March 31, 2007, we used approximately $11.8 million of cash for operations principally as a result of the net
loss of



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$11.5 million, the net change in operating assets and liabilities of $1.5 million, offset by the recording of $0.8 million in stock based compensation and
the recording of $0.3 million in depreciation and amortization and the recording of $0.1 million for the change in the value of the derivative associated with the subordinated convertible notes.

For the three months ended March 31, 2008, we received $9.2 million of cash from investing activities, primarily due to the maturities of our
short-term investment securities. For the three months ended March 31, 2007, we received $9.2 million of cash from investing activities, primarily due to the maturities of our short-term investment securities.

For the three months ended March 31, 2008, we received $2.5 million from financing activities, primarily as a result of net proceeds from our
revolving line of credit. For the three months ended March 31, 2007, we received $180,000 from financing activities, primarily as a result of proceeds from the exercise of stock options.

We believe that our existing cash balances, together with amounts available for borrowing under our credit facility, will be sufficient to fund our
operations for at least the next twelve months. However, our actual future capital requirements will depend on many factors, including the following:



| |  |  | the success of the commercialization of our products;
| | - |  | -----------------------------------------------------



| |  |  | sales and marketing activities, and expansion of our commercial infrastructure, related to our approved products and product candidates;
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------



| |  |  | the results of our clinical trials and requirements to conduct additional clinical trials;
| | - |  | ------------------------------------------------------------------------------------------



| |  |  | our research and development programs;
| | - |  | --------------------------------------



| |  |  | the time and expense necessary to obtain regulatory approvals;
| | - |  | --------------------------------------------------------------



| |  |  | activities and payments in connection with potential acquisitions of companies, products or technology;
| | - |  | -------------------------------------------------------------------------------------------------------



| |  |  | competitive, technological, market and other developments; and
| | - |  | --------------------------------------------------------------



| |  |  | our ability to establish and maintain collaborative relationships.
| | - |  | ------------------------------------------------------------------

These factors may cause us to seek to raise additional funds through additional sales of our debt or equity securities. There can be no assurance that funds from these sources will be available when needed or, if
available, will be on terms favorable to us or to our stockholders. If additional funds are raised by issuing equity securities, the percentage ownership of our stockholders will be reduced, stockholders may experience additional dilution or such
equity securities may provide for rights, preferences or privileges senior to those of the holders of our common stock.

We have never been
profitable, and we might never become profitable. In this regard, we anticipate that our operating expenses will continue to increase from historical levels as we continue to expand our commercial infrastructure in connection with our
commercialization of our approved products. As of March 31, 2008, our accumulated deficit was $316.1 million, including a net loss of approximately $13.0 million for the three months ended March 31, 2008 resulting in a stockholders
deficit of $13.5 million.



|Item 3 | Quantitative and Qualitative Disclosures about Market Risk
|------ | ----------------------------------------------------------

The primary objective of our investment activities is to preserve principal while at the same time maximizing the income we receive from our investments without significantly increasing risk. Some of the securities that we invest in may
have market risk. This means that a change in prevailing interest rates may cause the principal amount of the investment to fluctuate. For example, if we hold a security that was issued with a fixed interest rate at the then-prevailing rate and the
prevailing interest rate later rises, the principal amount of our investment will probably decline. Seeking to minimize this risk, we maintain our portfolio of cash equivalents and short-term investments in a variety of securities, including
commercial paper, money market funds, government and non-government debt securities. The average duration of all of our investments in 2008 was less than one year. Due to the short-term nature of these investments, we believe we have no material
exposure to interest rate risk arising from our investments. A hypothetical 100 basis point adverse move in interest rates along the entire interest rate yield curve would not materially affect the fair market value of our interest sensitive
financial investments. Declines in interest rates over time will, however, reduce our investment income, while increases in interest rates over time will increase our interest expense. Historically, and as of March 31, 2008, we have not used
derivative instruments or engaged in hedging activities.



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All outstanding amounts under our revolving credit facility bear interest at a variable rate equal to the
lenders prime rate plus 0.5%, which is payable on a monthly basis and which may expose us to market risk due to changes in interest rates. As of March 31, 2008, we had $10.0 million outstanding under our credit facility. We estimate that
a 10% change in interest rates on our credit facility would not have had a material effect on our net loss for the three months ended March 31, 2008.

We have operated primarily in the United States. Accordingly, we have not had any significant exposure to foreign currency rate fluctuations.



|Item 4 | Controls and Procedures
|------ | -----------------------

Evaluation of disclosure controls and
procedures

Our management, with the participation and under the supervision of our Chief Executive Officer and Chief Financial Officer,
has evaluated the effectiveness of our disclosure controls and procedures (as defined in Exchange Act Rule 13a-15(e)) as of the end of the period covered by this Quarterly Report. The Chief Executive Officer and Chief Financial Officer have
concluded that our disclosure controls and procedures are effective based on their evaluation of these controls and procedures required by paragraph (b) of Exchange Act Rules 13a-15 and 15d-15. A controls system, no matter how well designed and
operated, cannot provide absolute assurance that the objectives of the controls are met, and no evaluation of controls can provide absolute assurance that all controls and instances of fraud, if any, within a company have been detected.

Changes in internal control over financial reporting

We have not made any significant changes to our internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) during the fiscal quarter ended March 31, 2008 that have materially affected, or are
reasonably likely to materially affect, our internal control over financial reporting.



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PART II. OTHER INFORMATION



|Item 1A | Risk Factors
|------- | ------------

Our Annual Report on Form 10-K for the year ended
December 31, 2007 contains a full discussion of our risk factors. There have been no material changes to the risk factors disclosed in our Form 10-K except for the risk factors set forth below.

Compliance with extensive government regulations to which we are subject is expensive and time consuming, and may result in the delay, cessation or cancellation of
product sales, introductions or modifications.

Extensive industry regulation has had, and will continue to have, a significant impact
on our business. All pharmaceutical companies, including us, are subject to extensive, complex, costly and evolving regulation by the federal government, principally the FDA and to a lesser extent by the U.S. Drug Enforcement Administration, or DEA,
and foreign and state government agencies. The Federal Food, Drug and Cosmetic Act, the Controlled Substances Act and other domestic and foreign statutes and regulations govern or influence the testing, manufacturing, packing, labeling, storing,
record keeping, safety, approval, advertising, promotion, sale and distribution of our products. Under certain of these regulations, we and our contract suppliers and manufacturers are subject to periodic inspection of our or their respective
facilities, procedures and operations and/or the testing of our products by the FDA, the DEA and other authorities, which conduct periodic inspections to confirm that we and our contract suppliers and manufacturers are in compliance with all
applicable regulations. The FDA also conducts pre-approval and post-approval reviews and plant inspections to determine whether our systems, or our contract suppliers and manufacturers processes, are in compliance with cGMP and other FDA
regulations.

We are dependent on receiving and maintaining FDA and other governmental approvals in order to manufacture, market, sell and
ship our products. Consequently, there is always a risk that the FDA or other applicable governmental authorities will not approve our products, or will take post-approval action limiting, modifying or revoking our ability to manufacture or sell our
products, or that the rate, timing and cost of such approvals will adversely affect our product introduction plans or results of operations.

To the extent that our products are reimbursed by Medicare, Medicaid or other federal programs, our marketing and sales activities will be subject to regulation. Federal agencies in recent years have initiated investigations against and
entered into multi-million dollar settlements with a number of pharmaceutical companies alleging violations of fraud and abuse provisions. We will need to ensure that our sales force is properly trained to comply with these laws. Even with such
training, there is a risk that some of our marketing practices could come under scrutiny, or that we will not be able to institute or continue certain marketing practices. The majority of states also have statutes or regulations similar to these
federal laws, which apply to items and services reimbursed under Medicaid and other state programs, or, in several states, apply regardless of the payor. In addition, some states have laws that require pharmaceutical companies to adopt comprehensive
compliance programs. Sanctions under these federal and state laws may include civil monetary penalties, exclusion of a manufacturers products from reimbursement under government programs, criminal fines and imprisonment. Because of the breadth
of these laws and the narrowness of the safe harbors, it is possible that some of our business activities could be subject to challenge under one or more of such laws.

In addition, the FDA imposes a number of complex regulatory requirements on entities that advertise and promote pharmaceuticals, including, but not limited to, standards and regulations for direct-to-consumer
advertising, off-label promotion, industry sponsored scientific and educational activities, and promotional activities involving the Internet. In April 2008, we received a subpoena from the United States District Attorneys office requesting
the production of documents regarding promotional, educational and other activities relating to Xibrom.

If our past or present operations
are found to be in violation of any of the laws described above or other similar governmental regulations to which we are subject, we may be subject to the applicable penalty associated with the violation which could adversely affect our ability to
operate our business and our financial results.

We face intense competition and rapid technological change that could result in the development of
products by others that are superior to the products we are developing. In addition, we face competition from manufacturers of generic drugs which may have an adverse impact on our product revenues.

We have numerous competitors in the United States and abroad, including major pharmaceutical and specialized biotechnology firms, universities and other
research institutions that may be developing competing products. Our competitors include, among others, Allergan, Alcon Laboratories, Inc., Amphastar Pharmaceuticals, Inc., Bausch & Lomb, Halozyme Therapeutics, Inc., Johnson &
Johnson, Novartis AG, Pfizer, Inc., and Inspire Pharmaceuticals, Inc. These competitors may develop technologies and products that are more effective or less costly than our current or future products or product



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candidates or that could render our technologies, products and product candidates obsolete or noncompetitive. Many of these competitors have substantially
more resources and product development, manufacturing and marketing experience and capabilities than we do. Many of our competitors also have more resources committed to and expertise in effectively commercializing, marketing, and promoting products
approved by the FDA, including communicating the effectiveness, safety and value of the products to actual and prospective customers and medical professionals. In addition, many of our competitors have significantly greater experience than we do in
undertaking preclinical testing and clinical trials of pharmaceutical product candidates and obtaining FDA and other regulatory approvals of products and therapies for use in healthcare.

We also face competition from manufacturers of generic drugs. The patent for our main product, Xibrom, expires in January 2009, at which point we may no
longer be able to prevent generic drug manufacturers, or other third parties, from manufacturing and selling a product containing bromfenac. If a third party were to develop and market such a product, our revenues may be adversely impacted.

Additionally, the FDA granted our Istalol product a BT rating, which means that prescriptions for Istalol cannot be
substituted legally at pharmacies with generic timolol maleate products. Nonetheless, we believe that certain pharmacies may have substituted, and may be continuing to substitute, Istalol prescriptions with generic timolol maleate solutions. We have
completed an educational campaign to make our customers and pharmacies aware of Istalols BT rating and that Istalol cannot be legally substituted at pharmacies with generic timolol maleate products. However, our efforts may not be successful
and pharmacies may continue to substitute Istalol subscriptions with generic timolol maleate solutions, which would negatively impact our results of operations.

Items 2  5. Not applicable.



|Item 6 | Exhibits
|------ | --------



|               |  |                                                                                                                                                                                                                                                          
|-------------- |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|Exhibit Number |  | Description                                                                                                                                                                                                                                              
|               | 
|10.1           |  | Loan Modification Agreement, dated March 26, 2008, by and between ISTA Pharmaceuticals, Inc. and Silicon Valley Bank (Incorporated by reference to Exhibit 10.1 of the Companys Current
Report on Form 8-K filed with the Commission on March 31, 2008).
|               | 
|31.1           |  | Certification of Chief Executive Officer Pursuant to Rule 13a-14(a)/15d-14(a) of the Securities Exchange Act of 1934.                                                                                                                                    
|               | 
|31.2           |  | Certification of Chief Financial Officer Pursuant to Rule 13a-14(a)/15d-14(a) of the Securities Exchange Act of 1934.                                                                                                                                    
|               | 
|32.1           |  | Certification of Chief Executive Officer Pursuant to Rule 13a-14(b)/15d-14(b) of the Securities Exchange Act of 1934 and 18 U.S.C. Section 1350.                                                                                                         
|               | 
|32.2           |  | Certification of Chief Financial Officer Pursuant to Rule 13a-14(b)/15d-14(b) of the Securities Exchange Act of 1934 and 18 U.S.C. Section 1350.                                                                                                         



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Signatures

Pursuant to the requirements of the Securities Exchange Act of 1934, ISTA Pharmaceuticals, Inc.
has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.



|                   |  |  |  |                                                                  
|------------------ |  |  |  | -----------------------------------------------------------------
|                   |  |  |  | ISTA PHARMACEUTICALS, INC. (Registrant)                          
|                   |  | 
|Dated: May 1, 2008 |  |  |  | /s/ Vicente Anido, Jr., Ph.D.                                    
|                   |  |  |  | Vicente Anido, Jr., Ph.D.                                        
|                   |  |  |  | President and Chief Executive Officer                            
|                   |  | 
|Dated: May 1, 2008 |  |  |  | /s/ Lauren P. Silvernail                                         
|                   |  |  |  | Lauren P. Silvernail                                             
|                   |  |  |  | Chief Financial Officer and Vice President, Corporate Development



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INDEX TO EXHIBITS



|               |  |                                                                                                                                                                                                                                                          
|-------------- |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|Exhibit Number |  | Description                                                                                                                                                                                                                                              
|               | 
|10.1           |  | Loan Modification Agreement, dated March 26, 2008, by and between ISTA Pharmaceuticals, Inc. and Silicon Valley Bank (Incorporated by reference to Exhibit 10.1 of the Companys Current
Report on Form 8-K filed with the Commission on March 31, 2008).
|               | 
|31.1           |  | Certification of Chief Executive Officer Pursuant to Rule 13a-14(a) / 15d-14(a) of the Securities Exchange Act of 1934.                                                                                                                                  
|               | 
|31.2           |  | Certification of Chief Financial Officer Pursuant to Rule 13a-14(a) / 15d-14(a) of the Securities Exchange Act of 1934.                                                                                                                                  
|               | 
|32.1           |  | Certification of Chief Executive Officer Pursuant to Rule 13a-14(b) / 15d-14(b) of the Securities Exchange Act of 1934 and 18 U.S.C. Section 1350.                                                                                                       
|               | 
|32.2           |  | Certification of Chief Financial Officer Pursuant to Rule 13a-14(b) / 15d-14(b) of the Securities Exchange Act of 1934 and 18 U.S.C. Section 1350.                                                                                                       



20