Federal Register / Vol. 87, No. 132 / Tuesday, July 12, 2022 / Notices 41317 

PICOTS (POPULATIONS, INTERVENTIONS, COMPARATORS, OUTCOMES, TIMING, AND SETTING)—Continued 

Inclusion Exclusion 

Study design and publication dates.All KQ: Focus will be on the best evidence available that permits 

direct comparisons to answer key questions.

RCTs will be initially sought; in the absence of RCTs, prospective 

comparative studies that control for confounding will be considered; if no comparative prospective studies are available, retrospective comparative studies that control for confounding will 

be considered.

In the absence of comparative studies, single arm (e.g., case series, pre-post studies) may be considered.

For evaluation of harms, comparative cohort and case-control 

studies will be included; we will focus on studies specifically 

designed to evaluate harms.

Studies of at least 10 patients per treatment arm. 

General: 

• Dosimetry modeling studies. 

• Non-human studies. 

• NRSI for effectiveness if RCTs are available. 

• Studies with <10 patients per arm. 

• Single arm studies (unless no comparative 

studies); if used, exclude studies of <10 

patients. 

• Case reports. 

Publication dates: Prior to 1985. 

Publication types: Conference abstracts or proceedings, editorials, letters, white papers, citations that have not been peer-reviewed, single 

site reports of multi-site studies. 

EBRT = external beam radiation therapy; HRQOL = health-related quality of life; IMRT = intensity modulated radiation therapy; KQ = key question; NRSI = nonrandomized studies of intervention; RCT = randomized controlled trial; RT = radiation therapy; SBRT = stereotactic radiation 

therapy. 

Dated: July 6, 2022. 

Mamatha Pancholi, 

Acting Chief of Staff, Chief Data Officer. 

[FR Doc. 2022–14735 Filed 7–11–22; 8:45 am] 

BILLING CODE 4160–90–P 

DEPARTMENT OF HEALTH AND 

HUMAN SERVICES 

Centers for Disease Control and 

Prevention 

[60Day-22–22GR; Docket No. CDC–2022– 

0081] 

Proposed Data Collection Submitted 

for Public Comment and 

Recommendations 

AGENCY: Centers for Disease Control and 

Prevention (CDC), Department of Health 

and Human Services (HHS). 

ACTION: Notice with comment period. 

SUMMARY: The Centers for Disease 

Control and Prevention (CDC), as part of 

its continuing effort to reduce public 

burden and maximize the utility of 

government information, invites the 

general public and other federal 

agencies the opportunity to comment on 

a proposed information collection, as 

required by the Paperwork Reduction 

Act of 1995. This notice invites 

comment on a proposed information 

collection project titled Milestone 

Tracker In-App survey to understand 

the outcome of the Milestone Tracker 

app on developmental surveillance. 

This project is designed to evaluate the 

Milestone Tracker mobile application 

(app) developed by CDC’s ‘‘Learn the 

Signs. Act Early.’’ program and will be 

used to understand how the app is being 

used, if users find it helpful, and if the 

app helped them to identify a possible 

developmental concern(s). 

DATES: CDC must receive written 

comments on or before September 12, 

2022. 

ADDRESSES: You may submit comments, 

identified by Docket No. CDC–2022– 

0081 by either of the following methods: 

• Federal eRulemaking Portal: 

www.regulations.gov. Follow the 

instructions for submitting comments. 

• Mail: Jeffrey M. Zirger, Information 

Collection Review Office, Centers for 

Disease Control and Prevention, 1600 

Clifton Road NE, MS H21–8, Atlanta, 

Georgia 30329. 

Instructions: All submissions received 

must include the agency name and 

Docket Number. CDC will post, without 

change, all relevant comments to 

www.regulations.gov. 

Please note: Submit all comments 

through the Federal eRulemaking portal 

(www.regulations.gov) or by U.S. mail to 

the address listed above. 

FOR FURTHER INFORMATION CONTACT: To 

request more information on the 

proposed project or to obtain a copy of 

the information collection plan and 

instruments, contact Jeffrey M. Zirger, 

Information Collection Review Office, 

Centers for Disease Control and 

Prevention, 1600 Clifton Road NE, MS 

H21–8, Atlanta, Georgia 30329; 

Telephone: 404–639–7570; Email: omb@

cdc.gov. 

SUPPLEMENTARY INFORMATION: Under the 

Paperwork Reduction Act of 1995 (PRA) 

(44 U.S.C. 3501–3520), federal agencies 

must obtain approval from the Office of 

Management and Budget (OMB) for each 

collection of information they conduct 

or sponsor. In addition, the PRA also 

requires federal agencies to provide a 

60-day notice in the Federal Register 

concerning each proposed collection of 

information, including each new 

proposed collection, each proposed 

extension of existing collection of 

information, and each reinstatement of 

previously approved information 

collection before submitting the 

collection to the OMB for approval. To 

comply with this requirement, we are 

publishing this notice of a proposed 

data collection as described below. 

The OMB is particularly interested in 

comments that will help: 

1. Evaluate whether the proposed 

collection of information is necessary 

for the proper performance of the 

functions of the agency, including 

whether the information will have 

practical utility; 

2. Evaluate the accuracy of the 

agency’s estimate of the burden of the 

proposed collection of information, 

including the validity of the 

methodology and assumptions used; 

3. Enhance the quality, utility, and 

clarity of the information to be 

collected; 

4. Minimize the burden of the 

collection of information on those who 

are to respond, including through the 

use of appropriate automated, 

electronic, mechanical, or other 

technological collection techniques or 

other forms of information technology, 

e.g., permitting electronic submissions 

of responses; and 

5. Assess information collection costs. 

Proposed Project 

Milestone Tracker In-App Survey to 

Understand the Outcome of the 

Milestone Tracker App on 

Developmental Surveillance—New— 

National Center on Birth Defects and 

Developmental Disabilities (NCBDDD), 

Centers for Disease Control and 

Prevention (CDC) 


jspears on DSK121TN23PROD with NOTICES1
41318 Federal Register / Vol. 87, No. 132 / Tuesday, July 12, 2022 / Notices 

Background and Brief Description 

The Centers for Disease Control and 

Prevention’s ‘‘Learn the Signs. Act 

Early.’’ program (LTSAE) promotes 

efforts to increase developmental 

monitoring across all 50 states, the 

District of Columbia, and other U.S. 

territories through its Act Early 

Initiatives and Act Early Ambassador 

program, which heavily promote use of 

CDC’s Milestone Tracker app. The app 

is a tool to help parents and others track 

and monitor their children’s 

developmental milestones and guide 

them on next steps for when a child is 

missing milestones or there are other 

concerns. 

Since the app release in 2017, the 

program has had limited capability to 

evaluate target outcomes and impact of 

use of the app. Without directly asking 

the app users, the program has no way 

to know if use of this app is helpful, has 

made a difference in terms of 

identifying developmental delays 

among children, or if it is helping 

children get the services and support 

they may need as a result. This webbased survey evaluation will allow 

LTSAE to collect this information and 

assess the outcomes and impact of this 

tool to determine if the app is having 

the intended impact and should be 

continued to be made available as is or 

with improvements. 

The goal of the LTSAE program is to 

improve early identification of 

developmental delays and disabilities 

by developing high-quality, evidence 

informed and parent-friendly tools and 

resources to facilitate ongoing familyengaged developmental monitoring. The 

Milestone Tracker app is one of these 

tools to help parents and other 

caregivers track early development and 

link parents and guardians to the 

appropriate care and resources. 

The goal of this project is to evaluate 

the Milestone Tracker app developed by 

CDC’s ‘‘Learn the Signs. Act Early.’’ 

program. The evaluation will consist of 

two brief web surveys at two distinct 

times during the app user experience. 

The objectives of these two short 

surveys is to understand how the app is 

being used, if users like the app/find it 

helpful, if the app helped them to 

identify a possible developmental 

concern, if they plan to use it again, and 

what happens as a result of using the 

app. The resulting survey data will be 

used to assess user satisfaction with the 

app as well as to evaluate short term 

and medium-term outcomes associated 

with its use. 

CDC requests OMB approval for an 

estimated 8,000 annual burden hours. 

There is no cost to respondents other 

than their time to participate. 

ESTIMATED ANNUALIZED BURDEN HOURS

Type of respondents Form name Number of 

respondents 

Number of 

responses per 

respondent 

Average 

burden per 

response 

(in hours) 

Total burden 

hours 

Individuals using the Milestone 

Tracker app.

Milestone Tracker In app Baseline 

Survey.

200,000 1 2/60 6,667 

Individuals using the Milestone 

Tracker App that have indicated a 

developmental concern.

Milestone Tracker App Follow-up 

Survey.

40,000 1 2/60 1,333 

Total ........................................... ........................................................... ........................ ........................ ........................ 8,000 

Jeffrey M. Zirger, 

Lead, Information Collection Review Office, 

Office of Scientific Integrity, Office of Science, 

Centers for Disease Control and Prevention. 

[FR Doc. 2022–14759 Filed 7–11–22; 8:45 am] 

BILLING CODE 4163–18–P 

DEPARTMENT OF HEALTH AND 

HUMAN SERVICES 

Centers for Disease Control and 

Prevention 

[30Day–22–22CA] 

Agency Forms Undergoing Paperwork 

Reduction Act Review 

In accordance with the Paperwork 

Reduction Act of 1995, the Centers for 

Disease Control and Prevention (CDC) 

has submitted the information 

collection request titled ‘‘Fire Fighter 

Fatality Investigation and Prevention 

Program Survey’’ to the Office of 

Management and Budget (OMB) for 

review and approval. CDC previously 

published a ‘‘Proposed Data Collection 

Submitted for Public Comment and 

Recommendations’’ notice on January 

31, 2022 to obtain comments from the 

public and affected agencies. CDC did 

not receive comments related to the 

previous notice. This notice serves to 

allow an additional 30 days for public 

and affected agency comments. 

CDC will accept all comments for this 

proposed information collection project. 

The Office of Management and Budget 

is particularly interested in comments 

that: 

(a) Evaluate whether the proposed 

collection of information is necessary 

for the proper performance of the 

functions of the agency, including 

whether the information will have 

practical utility; 

(b) Evaluate the accuracy of the 

agencies estimate of the burden of the 

proposed collection of information, 

including the validity of the 

methodology and assumptions used; 

(c) Enhance the quality, utility, and 

clarity of the information to be 

collected; 

(d) Minimize the burden of the 

collection of information on those who 

are to respond, including, through the 

use of appropriate automated, 

electronic, mechanical, or other 

technological collection techniques or 

other forms of information technology, 

e.g., permitting electronic submission of 

responses; and 

(e) Assess information collection 

costs. 

To request additional information on 

the proposed project or to obtain a copy 

of the information collection plan and 

instruments, call (404) 639–7570. 

Comments and recommendations for the 

proposed information collection should 

be sent within 30 days of publication of 

this notice to www.reginfo.gov/public/ 

do/PRAMain. Find this particular 

information collection by selecting 

‘‘Currently under 30-day Review—Open 

for Public Comments’’ or by using the 

search function. Direct written 

comments and/or suggestions regarding 

the items contained in this notice to the 

Attention: CDC Desk Officer, Office of 

Management and Budget, 725 17th 

Street NW, Washington, DC 20503 or by 

fax to (202) 395–5806. Provide written 

comments within 30 days of notice 

publication. 


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