Exhibit 4.1

FOURTH AMENDMENT TO CREDIT AGREEMENT

This Fourth Amendment to Credit Agreement (the "Fourth Amendment") is made as of this 28 day of September, 2007 by and among



in
consideration of the mutual covenants herein contained and benefits to be derived herefrom.

W I T N E S S E T H:

WHEREAS, on July 21, 2003, certain of the parties hereto entered into that certain Credit Agreement (as amended and in effect, the "Credit Agreement"); and

WHEREAS,
the Loan Parties have requested that the Lenders amend certain provisions of the Credit Agreement as set forth herein.

NOW,
THEREFORE, it is hereby agreed as follows:





---







2

---





IN
WITNESS WHEREOF, the parties have hereunto caused this Fourth Amendment to be executed and their seals to be hereto affixed as of the date first above written.

DUANE READE
as BorrowerBy:

DUANE READE INC., its General Partnerby

/s/JOHN K. HENRYName: John K. Henry
Title:Senior Vice President and
Chief Financial Officerby

/s/MICHELLE D. BERGMANName: Michelle D. Bergman
Title:Senior Vice President and General CounselBy:

DRII INC., its General Partnerby

/s/JOHN K. HENRYName: John K. Henry
Title:Senior Vice President and
Chief Financial Officerby

/s/MICHELLE D. BERGMANName: Michelle D. Bergman
Title:Senior Vice President and General CounselDUANE READE INC., as Facility Guarantorby

/s/JOHN K. HENRYName: John K. Henry
Title:Senior Vice President and
Chief Financial Officerby

/s/MICHELLE D. BERGMANName: Michelle D. Bergman
Title:Senior Vice President and General Counsel


3

---



DRII INC., as Facility Guarantorby

/s/JOHN K. HENRYName: John K. Henry
Title:Senior Vice President and
Chief Financial Officerby

/s/MICHELLE D. BERGMANName: Michelle D. Bergman
Title:Senior Vice President and General CounselDUANE READE INTERNATIONAL, INC., as Facility Guarantorby

/s/JOHN K. HENRYName: John K. Henry
Title:Senior Vice President and
Chief Financial Officerby

/s/MICHELLE D. BERGMANName: Michelle D. Bergman
Title:Senior Vice President and General CounselDUANE READE REALTY, INC., as Facility Guarantorby

/s/JOHN K. HENRYName: John K. Henry
Title:Senior Vice President and
Chief Financial Officerby

/s/MICHELLE D. BERGMANName: Michelle D. Bergman
Title:Senior Vice President and General CounselDUANE READE HOLDINGS, INC., as Facility Guarantorby

/s/JOHN K. HENRYName: John K. Henry
Title:Senior Vice President and
Chief Financial Officerby

/s/MICHELLE D. BERGMANName: Michelle D. Bergman
Title:Senior Vice President and General Counsel


4

---



BANK OF AMERICA, N.A.,
As Administrative Agent, as Collateral Agent, as
Issuing Bank, as Swingline Lender and as
LenderBy:

/s/CHRISTINE HUTCHINSONName: Christine Hutchinson
Title:Managing DirectorAddress:
100 Federal Street 9th Floor
Boston, Massachusetts 02110
Attn: Keith Vercauteren
Telephone: (617) 434-2385
Telecopy: (617) 790-1234


5

---



WACHOVIA BANK, NATIONAL ASSOCIATION, as Documentation Agent and LenderBy:

/s/THOMAS GRABOSKYName: Thomas Grabosky
Title:DirectorAddress: 1133 6th Avenue, New York, NY
Telephone: (212) 545-4346
Telecopy: (212) 545-4283


6

---



GENERAL ELECTRIC CAPITAL CORPORATION, as
Syndication Agent and LenderBy:

/s/ROBERT E. KELLYName: Robert E. Kelly
Title:Duly Authorized SignatoryAddress: 201 Merritt 7, Norwalk, CT 06856
Telephone: (203) 956-4061
Telecopy: (203) 956-4006


7

---



THE CIT GROUP/BUSINESS CREDIT, INC., as LenderBy:

/s/MATTHEW V. DEFRANCOName: Matthew V. DeFranco
Title:Assistant Vice PresidentAddress: 11 West 42nd Street
New York, NY 10036
Telephone: (212) 461-7715
Telecopy: (212) 461-7762


8

---



WELLS FARGO RETAIL FINANCE, LLC, as
Syndication Agent, as Co-Lead Arranger, and as LenderBy:

/s/EMILY ABRAHAMSONName: Emily Abrahamson
Title:Account Executive/ AVPAddress: One Boston Place, 18th Floor
Boston, Massachusetts 02108
Telephone: 617-854-7243
Telecopy: 617-523-4032


9

---



QuickLinks