**Exhibit 10.18(d)****EMPLOYMENT AGREEMENT**     This EMPLOYMENT AGREEMENT (“Agreement”) is made to be effective as of the first day of August,2007, between Introgen Therapeutics, Inc., a Delaware corporation (the “Company”), and David G.Nance (the “Employee”).BACKGROUND     The Company was founded in 1993, and is in the business of developing and commercializingtreatments for cancer. Employee has served as President and Chief Executive Officer sinceformation of the Company. The Board of Directors of the Company (the “Board”) has determined thatEmployee’s continued service as President and Chief Executive Officer is in the best interest ofthe Company. Employee desires to continue service in those capacities. Therefore, inconsideration of the compensation to be paid Employee hereunder, and the covenants of Employee setforth herein, the parties hereto have entered into this Agreement.AGREEMENT     1. Employee Duties. The Company will continue employment of the Employee as itsPresident and Chief Executive Officer for the Term (as hereinafter defined), with suchresponsibilities and duties as the Board of Directors may from time to time determine, consistentwith such job title. The Employee shall devote such time as is reasonably necessary to theperformance of his responsibilities and duties hereunder.     2. Salary and Bonuses. Employee will receive an aggregate base salary at the rate of$594,944 per annum during the Term; provided that the Compensation Committee of the Company willreview Employee’s base salary at least annually to ensure that it will be consistent with thecompensation paid by other public biotechnology companies to their Chief Executive Officers withcomparable duties and responsibilities. Installments of base salary shall be paid not lessfrequently than bi-weekly. Employee will also receive bonuses in the form of money, stock options,restricted stock, or other consideration as may be determined from time to time by the CompensationCommittee. It is anticipated that Employee will, at a minimum, participate in regular milestoneoption grants to Company officers.     3. Other Fringe Benefits. Employee will receive the following benefits during theTerm of Employment: 401K plan and stock option plan participation, comprehensive health, accident,major medical, disability and life insurance protection in accordance with the general policies ofthe Company as in effect from time to time.     4. Reimbursement of Expenses. The Company shall reimburse Employee for allreasonable, ordinary and necessary expenses incurred by him in the performance of his dutieshereunder, provided that Employee accounts to the Company therefore in the manner prescribed by theCompany for reimbursement of Employee’s expenses.
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     5. Vacation. Employee shall be entitled to a reasonable number of vacation days eachyear, and in any event shall receive at least as many vacation days as allowed any other CompanyEmployee. Unused vacation days may not be accumulated from year to year.     6. Term of Agreement. The term of this Agreement will commence on August 1, 2007, andcontinue until July 31, 2010 (“Initial Term”), and will thereafter continue from year-to-yearunless: (i) either party notifies the other in writing prior to the end of the Initial Term, orprior to the end of any twelve month period thereafter, that such party wishes to terminate thisAgreement at the end of such Initial Term or other period; or (ii) earlier termination occurspursuant to Section 7.     7. Termination of Employment.     7.1 Termination by Employer for Cause. The Company may terminate Employee’semployment only for “Cause.” A termination for Cause is a termination evidenced by a findingadopted in good faith by the Board that Employee (i) willfully and continually failed tosubstantially perform his duties with the Company (other than a failure resulting from Employee’sincapacity due to illness, physical or mental disability or other incapacity) and such failurecontinues after the Board has given written notice that Employee has failed to perform his duties,(ii) has been convicted of a felony, (iii) has breached this Agreement in any material respect ifsuch breach is not cured or remedied reasonably promptly after the Board has given written noticeto Employee providing a reasonable description of the breach, or (iv) engaged in conductconstituting willful malfeasance in connection with his employment which is materially anddemonstrably injurious to the Company and its subsidiaries taken as a whole, or (v) has been barredby the Securities Exchange Commission or any court or agency having jurisdiction from serving as anofficer of a publicly traded company. No act, or failure to act, on Employee’s part, shall beconsidered “willful” for purposes of (i) or (iv) above unless he has acted or failed to act with anabsence of good faith and without a reasonable belief that his action or failure to act was in thebest interests of the Company. Notwithstanding anything contained in this Agreement to thecontrary, no failure to perform by Employee after Notice of Termination (as hereinafter defined) isgiven by Employer shall constitute Cause for purposes of this Agreement. Termination for Causeshall be by action of the Board after giving Employee and his legal advisor an opportunity to meetwith the Board, contest the basis for termination, and to demonstrate that Employee’s continuedemployment is in the best interests of the Company.     7.2 Termination by Employee for Cause. In the event that Employee’s responsibilities,job title, or authority are materially altered by Employer, then Employee may terminate thisAgreement at any time.     7.3 Effect of Termination.          (i) If Employee’s employment hereunder shall be terminated by the Company for Cause pursuantto Section 7 hereof, this Agreement shall forthwith terminate except that Employee’s obligationsunder Section 9 shall continue unaffected.
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          (ii) If Employee’s employment hereunder shall be terminated by the Company other than forCause, Employee’s obligations under Section 9 shall terminate and the Company shall pay to theEmployee all compensation otherwise payable to the Employee hereunder to the same extent as if thisAgreement had not been terminated.          (iii) If Employee’s employment hereunder is terminated by Employee pursuant to Section 7.2,then all of Employee’s obligations and compensation hereunder shall cease except that Employeeshall be entitled to receive all compensation accrued under Section 2, 3, 4 and 5 but unpaid as ofthe date of termination.          (iv) If Employee’s employment hereunder is terminated by Employee other than pursuant toSection 7.2, then all of Employee’s obligations and compensation hereunder shall cease except thatEmployee shall be entitled to receive all compensation accrued under Section 2, 3, 4 and 5 butunpaid as of the date of termination, and Employee’s obligations under Section 9 will continue forone year after the date of termination.     8. Death of Employee. If Employee’s employment hereunder shall terminate because ofhis death, this Agreement shall forthwith terminate, except that Employee’s personal representativeshall be entitled to receive all compensation accrued in favor of Employee under Sections 2, 3, 4,and 5 but unpaid as of the date of death. All rights of Employee’s personal representative toreceive any further compensation hereunder or under any other plan, arrangement or procedure of theCompany shall terminate, to the extent not theretofore vested, except for any rights which arise byvirtue of Employee’s death under any such plan, arrangement or procedure.     9. Non-Compete. 9.1 Non-Competition. Employee agrees that he will not during the Term ofthis Agreement engage in, or otherwise directly or indirectly be employed by, or act asa consultant or lender to, or be a director, officer, employee, owner or partner of,any other business or organization that is now or shall hereafter be competing with theCompany. In the event that Employee should desire certainty as to whether an activitymight be viewed by Employer as a violation of Employee’s obligations to Employer,Employee may disclose to and seek approval of such activity by the CompensationCommittee of Employer’s Board of Directors. Any activity approved by such committeewill be deemed not to violate this Section 9.1 or any other provision of thisAgreement, or otherwise breach Employee’s employment obligations to Employer.
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     9.2 Nondisclosure of Confidential Information. (a) Employee shall not, without theprior written consent of the Company, divulge, or disclose to any other person, firm, partnership,corporation or other entity any Confidential Information pertaining to the business of the Company,except (i) while employed by the Company, in the business of and for the benefit of the Company,or (ii) when required to do so by a court of competent jurisdiction, by any governmental agencyhaving supervisory authority over the business of the Company, or by any administrative body orlegislative body (including a committee thereof) with purported or apparent jurisdiction to orderEmployee to divulge, or disclose such information. For purposes of this Section 10(a),“Confidential Information” shall mean non-public information concerning the Company’s financialdata, strategic business plans, product development (or other proprietary product data), customerlists, marketing plans or other non-public, proprietary and confidential information of theCompany, in each case which is not otherwise available to the public.     9.3 Breach of Section 9. Since a breach of the provisions of this Section 9 could notbe adequately compensated by money damages, the Company shall be entitled, in addition to any otherright and remedy available to it, to an injunction restraining such breach or threatened breach.Employee agrees that the provisions of this Section 9 are necessary and reasonable to protect theCompany in the conduct of its business. If any restriction contained in this Section 9 shall bedeemed to be invalid, illegal, or unenforceable by reason of the extent, duration, or geographicalscope thereof, or otherwise, then the court making such determination shall have the right toreduce such extent, duration, geographical scope, or other provisions hereof, and in its reducedform such restrictions shall then be enforceable in the manner contemplated hereby.     10. Warranties and Representations of the Employee. The Employee warrants andrepresents that the Employee is not subject to any agreement, contract, judgment, decree orlimitation the effect of which would prohibit, limit or otherwise restrict the employment of theEmployee by the Company pursuant to the terms of this Agreement.     11. Notices All notices, requests, consents and other communications required orpermitted to be given hereunder, shall be in writing and shall be deemed to have been duly given ifdelivered personally or sent by prepaid telegram, or mailed first-class, postage prepaid, byregistered mail (notices sent by telegram or mailed shall be deemed to have been given on the datesent), as follows (or to such other address as either party shall designate by notice in writing tothe other in accordance herewith):     If to the Employee:David G. Nance