**Exhibit 31.1**

 

**Certification of Chief Executive OfficerRequired by Rule 13a-14(a) (17 CFR 240.13a-14(a))**

 

I,Christopher B. Begley, certify that:

 

1. I havereviewed this Quarterly Report on Form 10-Q of Hospira, Inc.;

 

2. Basedon my knowledge, this report does not contain any untrue statement of amaterial fact or omit to state a material fact necessary to make the statementsmade, in light of the circumstances under which such statements were made, notmisleading with respect to the period covered by this report;

 

3. Basedon my knowledge, the financial statements, and other financial informationincluded in this report, fairly present in all material respects the financialcondition, results of operations and cash flows of Hospira as of, and for, theperiods presented in this report;

 

4.Hospira’s other certifying officer and I are responsible for establishing andmaintaining disclosure controls and procedures (as defined in Exchange ActRules 13a-15(e) and 15d-15(e)) and internal control over financial reporting(as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) forHospira and have:

 

(a)  Designed suchdisclosure controls and procedures, or caused such disclosure controls andprocedures to be designed under our supervision, to ensure that materialinformation relating to Hospira, including its consolidated subsidiaries, ismade known to us by others within those entities, particularly during theperiod in which this report is being prepared;

 

(b) Designed suchinternal control over financial reporting, or caused such internal control overfinancial reporting to be designed under our supervision, to provide reasonableassurance regarding the reliability of financial reporting and the preparationof financial statements for external purposes in accordance with generallyaccepted accounting principles;

 

(c) Evaluated theeffectiveness of Hospira’s disclosure controls and procedures and presented inthis report our conclusions about the effectiveness of the disclosure controlsand procedures, as of the end of the period covered by this report based onsuch evaluation; and

 

(d) Disclosed inthis report any change in Hospira’s internal control over financial reportingthat occurred during Hospira’s most recent fiscal quarter that has materiallyaffected, or is reasonably likely to materially affect, Hospira’s internalcontrol over financial reporting; and

 

5.Hospira’s other certifying officer and I have disclosed, based on our mostrecent evaluation of internal control over financial reporting, to Hospira’sauditors and the audit committee of Hospira’s board of directors:

 

(a) All significantdeficiencies and material weaknesses in the design or operation of internalcontrol over financial reporting which are reasonably likely to adverselyaffect Hospira’s ability to record, process, summarize and report financialinformation; and

 

(b) Any fraud,whether or not material, that involves management or other employees who have asignificant role in Hospira’s internal control over financial reporting.

 

 
| /s/  CHRISTOPHER  B. BEGLEY |   |
|---------------------------------------|--------|
| Christopher B. Begley,                |   |
| Chairman and Chief  Executive Officer |   |
|                                  |   |
| Date: November 8, 2007                |

 

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