**Exhibit4.5**

**HOSPIRA, INC.**

**OFFICERS’ CERTIFICATE**

**and**

**COMPANY ORDER**

March 23, 2007

With respect to the issuance by Hospira, Inc. (the “Company”)of $375,000,000 aggregateprincipal amount of Floating Rate Notes due 2010 (the “2010 Notes”),$500,000,000 aggregate principal amount of 5.55% Notes due 2012 (the “2012Notes”) and $550,000,000 aggregate principal amount of 6.05% Notes due 2017(the “2017 Notes” and, together with the 2010 Notes and the 2012 Notes, the “Notes”),Thomas E. Werner and Brian J. Smith, officers of the Company, certify pursuantto Sections 3.1 and 3.3 of the Indenture, dated as of June 14, 2004 (the “Indenture”),between the Company and LaSalle Bank National Association, as Trustee (the “Trustee”),as follows:

1.                                       Wehave read Sections 2.1, 3.1 and 3.3 of the Indenture and the definitionstherein relating hereto, reviewed the resolutions of the Board of Directors ofthe Company adopted on September 20, 2006 (attached as Exhibit B to theSecretary’s Certificate of even date herewith), the Actions of the AuthorizedOfficers of March 20, 2007 (attached as Exhibit C to the Secretary’sCertificate of even date herewith), conferred with executive officers of theCompany and, in our opinion, made such other examinations and investigations asare necessary to enable us to express an informed opinion as to whetherSections 2.1, 3.1 and 3.3 of the Indenture have been complied with.

2.                                       Basedon the above-described examinations and investigations, in our opinion, allconditions precedent relating to the authentication and delivery of the Notes,including those conditions under Sections 2.1, 3.1 and 3.3 of the Indenture,have been complied with.

3.                                       Theterms of the Notes are set forth in the Actions of the Authorized Officers,dated March 20, 2007 (attached as Exhibit C to the Secretary’s Certificate ofeven date herewith).

4.                                       Inaccordance with the provisions of Section 3.3 of the Indenture, the Trustee ishereby authorized and requested to authenticate the Notes and to deliver suchNotes to or at the direction of MorganStanley & Co. Incorporated, ABN AMRO Incorporated and Citigroup GlobalMarkets Inc., as managers of the several underwriters.

Capitalizedterms used herein and not otherwise defined herein shall have the respectivemeanings assigned thereto in the Indenture.

1

----

INWITNESS WHEREOF, the undersigned have executed this Officers’ Certificate andCompany Order as of the date first above written.
|        | **HOSPIRA,  INC.** |
|--------|--------------------|
|   | ** **         |
|   |               |   |
|   | By:                | /s/ Thomas E. Werner |   |
|   | Name:              | Thomas E. Werner |
|   | Title:             | Senior Vice President, Finance and   Chief Financial Officer |
|        |                    |  |  |  |  |

 
|        | By:    | /s/ Brian J. Smith                                    |   |
|--------|--------|-------------------------------------------------------|--------|
|   | Name:  | Brian J. Smith                                        |
|   | Title: | Senior Vice President, General Counsel  and Secretary |
|        |        |                                                       |        |  |

 

2

----