**Exhibit31.1**

**Certification ofChief Executive OfficerRequired by Rule 13a-14(a) (17 CFR 240.13a-14(a))**

I, Christopher B.Begley, certify that:

1.                  Ihave reviewed this Quarterly Report on Form 10-Q of Hospira, Inc.;

2.                  Basedon my knowledge, this report does not contain any untrue statement of amaterial fact or omit to state a material fact necessary to make the statementsmade, in light of the circumstances under which such statements were made, notmisleading with respect to the period covered by this report;

3.                  Basedon my knowledge, the financial statements, and other financial informationincluded in this report, fairly present in all material respects the financialcondition, results of operations and cash flows of Hospira as of, and for, theperiods presented in this report;

4.                  Hospira’sother certifying officer and I are responsible for establishing and maintainingdisclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e)and 15d-15(e)) and internal control over financial reporting (as defined inExchange Act Rules 13a-15(f) and 15d-15(f)) for Hospira and have:

(a)            Designedsuch disclosure controls and procedures, or caused such disclosure controls andprocedures to be designed under our supervision, to ensure that material informationrelating to Hospira, including its consolidated subsidiaries, is made known tous by others within those entities, particularly during the period in whichthis report is being prepared;

(b)           Designedsuch internal control over financial reporting, or caused such internal controlover financial reporting to be designed under our supervision, to providereasonable assurance regarding the reliability of financial reporting and thepreparation of financial statements for external purposes in accordance withgenerally accepted accounting principles;

(c)            Evaluatedthe effectiveness of Hospira’s disclosure controls and procedures and presentedin this report our conclusions about the effectiveness of the disclosurecontrols and procedures, as of the end of the period covered by this reportbased on such evaluation; and

(d)           Disclosedin this report any change in Hospira’s internal control over financialreporting that occurred during Hospira’s most recent fiscal quarter that hasmaterially affected, or is reasonably likely to materially affect, Hospira’sinternal control over financial reporting; and

5.                  Hospira’sother certifying officer and I have disclosed, based on our most recentevaluation of internal control over financial reporting, to Hospira’s auditorsand the audit and public policy committee of Hospira’s board of directors:

(a)            Allsignificant deficiencies and material weaknesses in the design or operation ofinternal control over financial reporting which are reasonably likely toadversely affect Hospira’s ability to record, process, summarize and reportfinancial information; and

(b)           Any fraud, whether ornot material, that involves management or other employees who have asignificant role in Hospira’s internal control over financial reporting.
| /s/  CHRISTOPHER B. BEGLEY |   |   |
|----------------------------|--------|--------|
| Christopher B. Begley,     |   |   |
| Chief Executive Officer    |   |   |
|                       |   |   |
| Date: August 9, 2006       |   |   |

 

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