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United StatesSecurities and Exchange Commission Washington, D.C. 20549 Form 20–F [   ] Registration Statement pursuant to section 12(b) or (g) of the Securities Exchange Act of 1934 or [ X ] Annual Report pursuant to section 13 or 15(d) of the Securities Exchange Act of 1934 For the fiscal year ended December 31, 2012 or [   ] Transition Report pursuant to section 13 or 15(d) of the Securities Exchange Act of 1934 or [   ] Shell Corporation Report pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of event requiring this Shell Corporation Report for the transition period from ________ to ________ Commission File Number: 001-12033 NYMOX PHARMACEUTICAL CORPORATION(Exact name of registrant as specified in its charter) Canada(Jurisdiction of incorporation or organization) 9900 Cavendish Blvd., Suite 306 St. Laurent, Quebec, Canada, H4M 2V2 (Address of principal executive offices) Contact person: Roy WolvinTel. 800-936-9669, e-mail: rwolvin@nymox.com,fax: 514-332-2227(name, telephone, e-mail and/or facsimile number and address of company contact person) Securities registered or to be registered pursuant to Section 12(b) of the Act. Title of each class

   Name of each exchange on which registeredCommon Stock

   The NASDAQ Stock Market LLC (NASDAQ Capital Market)
 Securities registered or to be registered pursuant to Section 12(g) of the Act None Securities for which there is a reporting obligation pursuant to Section 15(d) of the Act None Indicate the number of outstanding shares of each of the issuer's classes of capital or common stock as of the close of the period covered by the annual report. 33,572,442 shares as of December 31, 2012 Indicate by check mark if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act. Yes [   ] No [ X ] If this report is an annual or transition report, indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Yes [   ] No [ X ] Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. Yes [ X ] No [   ] Indicate by check mark whether the registrant has submitted electronically and posted on its corporate website; if any, every interactive Date File required to be submitted and posted pursuant to Rule 405 of Regulation S-T (§232-405 of this chapter) during the preceding twelve months (or for such shorter period that the registrant was required to submit and post such files). Yes [   ] No [   ] 1


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Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, or a non-accelerated filer. See definition of “accelerated filer and large accelerated filer” in Rule 12b-2 of the Exchange Act. (Check one): Large accelerated filer [   ] Accelerated filer [ X ] Non-accelerated filer [   ] Indicate by check mark which basis of accounting the registrant has used to prepare the financial statements included in this filing: U.S. GAAP [   ]

   International Financial Reporting Standards [ X ]

   Other [   ]as issued by the International Accounting Standards Board.
 If “Other” has been checked in response to the previous question, indicate by check mark which financial statement item the registrant has elected to follow: Item 17 [   ] Item 18 [   ] If this is an annual report, indicate by check mark whether the registrant is a shell Company (as defined in Rule 12b-2 of the Exchange Act). Yes [   ] No [ X ] 2


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In this annual report, the terms “Nymox”, “The Corporation”, “we” and “us” refers to both Nymox Pharmaceutical Corporation and its subsidiaries, Nymox Corporation and Serex Inc. Unless otherwise indicated all dollar amounts are in United States Dollars. CAUTIONARY STATEMENT REGARDING FORWARD-LOOKING STATEMENTS You should be aware that this report contains forward-looking statements about, among other things, the anticipated operations, product development, financial condition and operating results of Nymox, proposed clinical trials and proposed transactions, including collaboration agreements. By forward-looking statements, we mean any statements that are not statements of historical fact, including (but not limited to) statements preceded by or that include the words, “believes”, “expects”, “anticipates”, “hopes”, “targets” or similar expressions. In connection with the “safe harbor” provisions in the Private Securities Litigation Reform Act of 1995, we are including this cautionary statement to identify some of the important factors that could cause Nymox’s actual results or plans to differ materially from those projected in forward-looking statements made by, or on behalf of, Nymox. These factors, many of which are beyond the control of Nymox, include Nymox’s ability to: identify and capitalize on possible collaboration, strategic partnering or divestiture opportunities;obtain suitable financing to support its operations and clinical trials;manage its growth and the commercialization of its products;achieve operating efficiencies as it progresses from a development-stage to a later-stage biotechnology corporation;successfully compete in its markets;realize the results it anticipates from the clinical trials of its products;succeed in finding and retaining joint venture and collaboration partners to assist it in the successful marketing, distribution and commercialization of its products;achieve regulatory clearances for its products;obtain on commercially reasonable terms adequate product liability insurance for its commercialized products and avoid product liability claims;adequately protect its proprietary information and technology from competitors and avoid infringement of proprietary information and technology of its competitors;assure that its products, if successfully developed and commercialized following regulatory approval, are not rendered obsolete by products or technologies of competitors; andnot encounter problems with third parties, including key personnel, upon whom it is dependent. Although Nymox believes that the forward-looking statements contained in this annual report are reasonable, it cannot ensure that its expectations will be met. These statements involve risks and uncertainties. Actual results may differ materially from those expressed or implied in these statements. Factors that could cause such differences include, but are not limited to, those discussed under “Risk Factors.” 3


PART I ITEM 1. IDENTITY OF DIRECTORS, SENIOR MANAGEMENT AND ADVISERSNot Applicable ITEM 2. OFFER STATISTICS AND EXPECTED TIMETABLENot Applicable ITEM 3. KEY INFORMATION Selected Financial Data The following table sets forth selected consolidated financial data for Nymox for the periods indicated, derived from financial statements prepared in accordance with International Financial Reporting Standards (“IFRS”) as issued by the International Accounting Standards Board (“IASB”) for 2012, 2011 and 2010 and in accordance with Canadian generally accepted accounting principles (“GAAP”), reconciled to U.S. GAAP, for 2009 and 2008. The financial statements have been audited by KPMG LLP, Montreal, Canada as at and for the years ended December 31, 2008, 2009, 2010, 2011 and 2012 and are reported in U.S. dollars. The data set forth below should be read in conjunction with the Corporation’s consolidated financial statements and notes thereto included in Part I, Item 8 of this report. NYMOX PHARMACEUTICAL CORPORATIONSelected Consolidated Financial Data(In U.S. dollars) IFRS

   

   Dec. 31, 2012

   

   

   Dec. 31, 2011

   

   

   Dec. 31, 2010Current Assets

   $

   1,739,061

   

   $

   6,335,710

   

   $

   13,470,096Property & Equipment

   

   15,118

   

   

   22,160

   

   

   14,730Patents & Intellectual Property

   

   0

   

   

   

   

   

   0Total Assets

   

   1,754,179

   

   

   6,375,266

   

   

   13,502,222Total Current Liabilities

   

   3,672,759

   

   

   3,429,092

   

   

   5,195,503Share Capital

   

   69,705,389

   

   

   66,062,961

   

   

   62,855,147Equity

   

   (7,444,713

   )

   

   (5,197,559

   )

   

   (2,454,614

   )Sales

   

   454,987

   

   

   496,215

   

   

   582,383Total Revenues (including sales)

   

   3,072,587

   

   

   3,113,815

   

   

   691,450Research & Development Expenditures (1)

   

   8,282,762

   

   

   8,974,171

   

   

   4,880,126Loss from operating activities

   

   7,594,651

   

   

   9,625,327

   

   

   6,505,132Net Loss

   

   7,627,589

   

   

   9,652,389

   

   

   6,536,313Loss per Share (basic & diluted)

   $

   0.23

   

   $

   0.30

   

   $

   0.20Weighted Avg. No. of Common Shares

   

   33,176,185

   

   

   32,711,431

   

   

   31,940,584
  (1)

   We earn research tax credits by making qualifying research and development expenditures. These amounts shown are net of research tax credits and grants.(2)

   The Corporation adopted IFRS in 2011 with a transition date of January 1, 2010. Consequently, the selected consolidated financial data for 2009 and 2008, which was presented in conformity with Canadian GAAP, and with U.S. GAAP, was not restated in accordance with IFRS and accordingly, is not comparable with the information for 2012, 2011 and 2010. Canadian GAAP(2)

   

   Dec. 31, 2009

   

   

   Dec. 31, 2008Current Assets

   $

   1,074,279

   

   $

   480,505Property & Equipment

   

   16,152

   

   

   21,525Patents & Intellectual Property

   

   0

   

   

   220,855Total Assets

   

   1,090,431

   

   

   749,879Total Current Liabilities

   

   1,742,597

   

   

   1,256,885Share Capital

   

   57,955,147

   

   

   53,850,147Equity

   

   (1,452,166

   )

   

   (1,307,006

   )Sales

   

   415,980

   

   

   426,675Total Revenues (including sales)

   

   415,980

   

   

   428,409Research & Development Expenditures (1)

   

   3,043,219

   

   

   2,388,911Loss from operating activities

   

   5,125,125

   

   

   4,631,637Net Loss

   

   5,130,074

   

   

   4,637,103Loss per Share (basic & diluted)

   $

   0.17

   

   $

   0.16Weighted Avg. No. of Common Shares

   

   30,717,822

   

   

   29,749,000U.S. GAAP(2)Net Loss

   $

   5,282,534

   

   $

   4,590,345Loss per Share

   

   0.17

   

   

   0.15Shareholder’s Equity

   

   2,102,997

   

   

   2,400,617
 Nymox has never paid any dividends and does not expect to do so in the foreseeable future. 4


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Risk Factors Investing in our securities involves a significant degree of risk. You should carefully consider the risks described below, together with all of the other information in our publicly filed documents, before making an investment decision. If any of the following risks actually occurs, our business, financial condition or results of operations could be adversely affected. In such an event, the trading price of our Common Shares could decline and shareholders may lose part or all of their investment in our securities. Our Clinical Trials for our Therapeutic Products in Development, Such as NX-1207, May Not Be Successful and We May Not Receive the Required Regulatory Approvals Necessary to Commercialize These Products Products requiring regulatory approval, such as NX-1207, will be approved for commercial sale only if governmental regulatory authorities are satisfied that our clinical trials are properly designed and conducted and that the results of those trials provide valid and acceptable evidence that the product is safe and effective for the conditions or diseases it is intended to treat. We do not know whether our pending or any future clinical trials will demonstrate sufficient safety and efficacy to obtain the requisite regulatory approvals or will result in marketable products. Clinical trials are lengthy, complex, expensive and uncertain processes and failure can occur at any stage of testing. Results attained in pre-clinical testing or in early clinical trials may not be indicative of results that are obtained in later studies. We may suffer significant setbacks in advanced clinical trials, even after promising results in earlier studies. Based on results at any stage of clinical trials, we may decide to repeat or redesign a trial or discontinue development of one or more of our product candidates. If we fail to adequately demonstrate the safety and efficacy of our products under development, we will not be able to obtain the required regulatory approvals to commercialize our product candidates. Failure to obtain such approval could cause the price of our shares to decline and adversely affect our business, operations, product development programs and financial condition. Our Clinical Trials for Our Therapeutic Products, Such as NX-1207, May Be Delayed, Making it Impossible to Achieve Anticipated Development or Commercialization Timelines Delays in the initiation, conduct or completion of clinical trials are not uncommon. If one or more of our clinical trials is delayed, we may be unable to meet our anticipated development or commercialization timelines. Either circumstance could cause the price of our shares to decline, increase clinical trial and product development costs, and affect the Corporation’s business, operations, product development programs and financial condition. The design, conduct and completion of clinical trials is a complex process involving many third parties, including governmental authorities, institutional review boards, contract manufacturers, contract research organizations (CROs), consultants, investigators, patients, and data monitoring committees. The initiation, progress, completion and success of a clinical trial is in part dependent on third parties providing necessary approvals, agreements and consents, performing necessary tasks in a timely, competent manner, and complying with protocols, good clinical practices and applicable laws, rules and regulations. Failure of a third party to perform as expected or agreed upon may result in delays or failure in initiating or completing a clinical trial. Our clinical trials are subject to prior approvals and continuing oversight by governmental regulatory authorities and institutional review boards. We must meet and comply with their requirements in order to start, continue and successfully complete a clinical trial. We may not be able to comply with one or more of these requirements or there may be delays in doing so. A clinical trial may be put on hold or halted altogether due to concerns about patient safety. Governmental regulatory authorities may change approvals or requirements, resulting in changes to the design or conduct of a clinical trial or the need for new or further clinical trials. Clinical trials for our product candidates require that we identify and enroll a large number of patients with the disorder under investigation. We may not be able to enroll a sufficient number of patients to complete our clinical trials in a timely manner. Patient enrollment is a function of many factors including: design of the protocol;the size of the patient population;eligibility criteria for the study in question;perceived risks and benefits of the drug under study;availability of competing therapies;efforts to facilitate timely enrollment in clinical trials;patient referral practices of physicians; andavailability of clinical trial sites. If we have difficulty enrolling a sufficient number of patients to conduct our clinical trials as planned, we may need to delay or terminate ongoing clinical trials. A Setback in Any of Our Clinical Trials Would Likely Cause a Drop in the Price of Our Shares We have successfully completed several Phase 1 and Phase 2 multi-center, blinded and controlled clinical trials, and follow-up studies, in the U.S. for NX-1207, our drug candidate for the treatment of enlarged prostate (benign prostatic hyperplasia or “BPH”), and we are currently in Phase 3. The clinical testing of drug candidates is fraught with uncertainties and positive results 5


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from earlier clinical trials may not be repeated in later trials. As well, government regulators such as the U.S. Food and Drug Administration, or FDA, may require additional testing or further documentation relating to the preclinical testing, clinical studies, manufacturing or other issues at any time. These requirements may result in substantial delays in obtaining regulatory approval or make obtaining such approval much more difficult. Setbacks in any phase of the clinical development of our product candidates could have a negative impact on our business, operations, product development programs and financial condition, could jeopardize FDA or other regulatory approval and would likely cause a drop in the price of our shares. We May Not be Able to Make Adequate Arrangements with Third Parties for the Commercialization of Our Product Candidates, such as NX-1207 In order to commercialize our product candidates successfully, we intend, on a product-by-product basis, either to make arrangements with third parties to perform some or all of these services or to expand our existing sales, marketing and distribution capabilities. We currently have limited sales and marketing capabilities and limited experience in developing, training or managing a large marketing or sales force. We currently rely primarily upon distributors for the sales of our existing products. The cost of establishing and maintaining a larger sales force would be substantial and may exceed its cost effectiveness. In addition, in marketing our products, we would likely compete with many companies that currently have extensive and well-funded marketing and sales operations. Despite our marketing and sales efforts, we may be unable to compete successfully against these companies. We may make arrangements with third parties to market and sell some or all of our products under development in certain territories, rather than establish our own sales force. We may not be able to do so on favorable terms. If we contract with third parties for the sales and marketing of our products, our revenues will depend upon the efforts of these third parties, whose efforts may not be successful. We anticipate entering into co-development and co-marketing agreements with one or more partners with established sales, marketing and regulatory capabilities in order to assist in the completion of the development and commercialization of NX-1207. We may not be able to do so on favourable terms. If we fail to establish or make adequate arrangements with third parties for such purposes, our business, operations, product development programs and financial condition will be materially adversely affected. In December 2010, the Corporation signed a license and collaboration agreement with Recordati, a European pharmaceutical group, for the development and commercialization of NX-1207 in Europe including Russia and the CIS, the Middle East, the Maghreb area of North Africa and South Africa (the “Licensed Territory”). The license and collaboration agreement covers the use of NX-1207 for the treatment of BPH as the initial indication for development and commercialization. The success of this agreement is contingent on Recordati’s ability to secure marketing approval from the European Medicines Agency (EMA) and other government regulatory agencies in the Licensed Territory. Failure to secure such approvals, inability to establish satisfactory reimbursement prices for sale of approved products, and difficulties with commercialization in the Licensed Territory could significantly impact our revenues from this agreement. We May Not Achieve Our Projected Development Goals in the Time Frames We Announce and Expect We make public statements regarding the achievement of our milestones, such as the commencement and completion of clinical trials, regulatory submission and approval dates and time of product launch. The actual timing of these events can vary dramatically due to factors such as delays or failures in our clinical trials, the uncertainties inherent in the regulatory approval process and delays in achieving manufacturing or marketing arrangements sufficient to commercialize our products. There can be no assurance that our clinical trials will be completed, that we will make regulatory submissions or receive regulatory approvals as planned or that we will be able to adhere to our current schedule for the launch of any of our products. If we fail to achieve one or more of these milestones as planned, the price of our shares could decline. Even If We Obtain Regulatory Approvals for Our Product Candidates, We Will be Subject to Stringent Ongoing Government Regulation Even if regulatory authorities approve any of our product candidates, the manufacture, marketing and sale of such products will be subject to strict and ongoing regulation. Compliance with such regulation will be expensive and consume substantial financial and management resources. For example, an approval for a product may be conditioned on our conducting costly post-marketing follow-up studies. In addition, if based on these studies, a regulatory authority does not believe that the product demonstrates a benefit to patients, such authority could limit the indications for which the product may be sold or revoke the product’s regulatory approval. We and our contract manufacturers will be required to comply with applicable current Good Manufacturing Practice (“cGMP”) regulations for the manufacture of our products. These regulations include requirements relating to quality assurance, as well as the corresponding maintenance of records and documentation. Manufacturing facilities must be approved before we can use them in commercial manufacturing of our products and are subject to subsequent periodic inspection by regulatory authorities. In addition, material changes in the methods of manufacturing or changes in the suppliers of raw materials are subject to further regulatory review and approval. If we or any marketing collaborators or contract manufacturers fail to comply with applicable regulatory requirements, we may be subject to sanctions including fines, product recalls or seizures, injunctions, total or partial suspension of production, civil penalties, withdrawals of previously granted regulatory approvals and criminal prosecution. Any of these penalties could delay or prevent the development, marketing or sale of our products. 6


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It is Uncertain When, if Ever, We Will Make a Profit We first began operations in 1995 and are only in the early stages of commercial marketing of our diagnostic products, AlzheimAlertTM, NicAlertTM and TobacAlertTM. We have never made a profit. We incurred a net loss of approximately $9.7 million in 2011 and $7.6 million in 2012. As of December 31, 2012, Nymox’s accumulated deficit was approximately $89.9 million. We cannot say when, if ever, Nymox will become profitable. Profitability will depend on our uncertain ability to generate revenues from the sale of our products and the licensing of our technology that will offset the significant expenditures required for us to advance our research, protect and extend our intellectual property and develop, manufacture, license, market, distribute and sell our technology and products successfully. Similar types of expenditures in the past have contributed to the net losses reported above. We May Not Be Able to Raise Enough Capital to Develop and Market Our Products Nymox has funded its operations primarily by selling shares of its common stock. Since late 1998, a small portion of the funds came from sales. However, sales have not been, and may not be in the foreseeable future, sufficient to meet our anticipated financial requirements. In December 2010, the Corporation received an upfront payment of € 10 million (US$13.1 million) pursuant to a license and collaboration agreement with Recordati for the development and commercialization of NX-1207 in the Licensed Territory. Future payments under this agreement are contingent in part on Recordati’s ability to secure regulatory approvals in the licensed territory and may be delayed or not occur. We will continue to need to raise substantial amounts of capital for our business activities including our research and development programs, the conduct of clinical trials needed to obtain regulatory approvals and the marketing and sales of our products. We anticipate being able to fund our current total annual budgeted expenditures of approximately $6.5 – 9.7 million per year over the next year through our current cash position and additional financing, including drawdowns through our Common Stock Private Purchase agreement with Lorros-Greyse Investments, Ltd. (“Lorros-Greyse”). The Corporation must comply with general covenants in order to draw on its facility including maintaining its stock exchange listing and registration requirements and having no material adverse effects, as defined in the agreement, with respect to the business and operations of the Corporation. Clinical trials will substantially increase cash requirements. We anticipate being able to meet these requirements as they arise. We plan to raise capital either through a new round of financing and/or through partnering with a major pharmaceutical corporation. The financial crisis in the United States and the global economic recession has had a negative impact on the availability of liquidity in the market and may have an effect on the liquidity of Lorros-Greyse. Additional financing may not be available when needed, or, if available, may not be available on acceptable terms. If adequate funds on acceptable terms are not available, we may have to curtail or eliminate expenditures for research and development, testing, clinical trials, promotion and marketing for some or all of our products. We Face Challenges in Developing, Manufacturing and Improving Our Products Our success depends on our ability to develop or acquire rights to new products or to improve our existing products. We are still developing many of our products and have not yet brought them to market. We cannot assure you that we will be able to develop or acquire rights to such products and to market them successfully. Developing a treatment for Alzheimer’s disease is particularly challenging. Many pharmaceutical companies, institutions and researchers are working on many different approaches and treatments. There is no consensus among researchers about the cause of this fatal illness and no guarantee that our drug development programs in this area are targeting significant factors in its cause, progression or symptoms. It is difficult to design drug candidates that can cross from the bloodstream into the brain, where the damage from Alzheimer’s disease is occurring. Clinical trials to establish efficacy for drugs that slow down the progression of Alzheimer’s disease over a period of months or years often require that a large number of subjects be tracked over many months or years, making them very expensive to conduct. The potentially long period from discovery and patenting through development and regulatory approval to the market can significantly reduce the patent life of an Alzheimer’s disease treatment. Any marketed treatment in this area may well eventually face competition from “me-too” drugs developed by other pharmaceutical companies based on our research. We will be under constant competitive pressure to improve our products and to develop new treatments in order to protect our position in the field. Developing and improving our diagnostic products is also challenging. The science and technology of the detection and measurement of very small amounts of biochemicals in bodily fluids and tissue is evolving rapidly. We may need to make significant expenditures in research and development costs and licensing fees in order to take advantage of new technologies. If any major changes to our testing technologies used in our AlzheimAlertTM, NicAlertTM or TobacAlertTM tests are made, further validation studies will be required. Developing new diagnostic products is more challenging, requiring identification and validation of the biochemical marker being detected by the new product in the clinical context and the development and validation of the product designed to detect the marker. We anticipate outsourcing at least some of the manufacturing required for new products we may develop in order to control start-up and operating costs and to take advantage of the existing manufacturing capabilities and capacity in the large contract manufacturing sectors in the pharmaceutical and diagnostic industries. There are risks associated with this strategy, including difficulties in the transfer of manufacturing, the possibility of production interruption due to causes beyond our control and the need to arrange alternative suppliers. We currently out-source some of the manufacturing services required for our NicAlertTM 7


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and TobacAlertTM products to a contract manufacturer. We do not anticipate any significant risk of long-term interruption of manufacture due to this arrangement. The services supplied are not unique or unduly complicated and other contract manufacturers are available to provide similar services. The manufacture of therapeutics is more challenging and capital-intensive and may require us to partner with a major pharmaceutical corporation or other partner in order to manufacture a therapeutic for market. Our Products and Services May Not Receive Necessary Regulatory Approvals Our diagnostic products, AlzheimAlertTM, NicAlertTM and TobacAlertTM, and our products in development, are subject to a wide range of government regulation governing laboratory standards, product safety and efficacy. The actual regulatory schemes in place vary from country to country and regulatory compliance can take several years and involve substantial expenditures. We cannot be sure that we can obtain necessary regulatory approvals on a timely basis, if at all, for our products in development and all of the following could have a material adverse effect on our business: failure to obtain or significant delays in obtaining requisite approvals;loss of or changes to previously obtained approvals; andfailure to comply with existing or future regulatory requirements. Any changes in the Centers for Medicare and Medicaid Services (“CMS”) or state law requirements or in the U.S. Food and Drug Administration (“FDA”) regulations could have a detrimental impact on our ability to offer or market any reference laboratory services and/or on our ability to obtain reimbursement from the Medicare and Medicaid programs and providers. We have developed a diagnostic kit based on AlzheimAlertTM for sale to third parties. We will require prior approval from the FDA before we can market, distribute or sell this product in the United States. In July 2005, an FDA advisory panel voted 5-2 against approval of our kit, citing the need for further studies, such as long term follow-up and autopsy confirmation. Similar requirements exist in many other countries. Obtaining these approvals and complying with the subsequent global regulatory requirements can be both time-consuming and expensive. In the United States, our drugs in development will require final FDA approval before their sale or distribution. Such approval comes only at the end of a lengthy, expensive and often arduous process. In September, 2006, we announced the successful completion of a multi-center, double-blind, placebo-controlled Phase 2 trial of NX-1207, our lead candidate for the treatment of BPH, a common disorder of older men. In February 2008, the Corporation reported positive results in a 32 site U.S. Phase 2 prospective randomized clinical trial, with statistically significant improvement compared to an approved BPH drug (finasteride). Subsequent to the completion of the Phase 2 studies, the Corporation has reported positive results in several follow-up studies of BPH patients that participated in the Phase 2 studies. In February 2009, the Corporation reported concluding a positive and productive End of Phase 2 (“EOP2”) meeting with the FDA concerning the Phase 3 program for NX-1207. In June 2009, the Corporation began conducting the first of two pivotal double blind placebo controlled Phase 3 trials for NX-1207 that incorporate the specific protocol design recommendations provided to the Corporation by the FDA. The two pivotal Phase 3 studies for NX-1207 are being conducted at well-known investigational sites across the U.S. with planned enrollment of 1,000 patients. On March 1, 2012 Nymox announced the initiation of a Phase 2 U.S. clinical trial to evaluate NX-1207 for the treatment of low grade localized prostate cancer. On November 28, 2012, Nymox announced completion of patient enrollment in the Corporation’s pivotal U.S. Phase 3 NX02-0017 Study of NX-1207 for BPH. We cannot predict with any certainty the outcome of this program, what further steps may be required in order to apply for final FDA approval for this drug or whether the FDA will ultimately grant us such approval. Similar requirements exist in many other countries. We Face Significant and Growing Competition The modern pharmaceutical and biotechnology industries are intensely competitive, particularly with respect to Alzheimer’s disease where there is a large unmet need for an effective treatment. Currently there are five drugs with similar mechanisms of action approved for sale in the United States (Aricept®, Cognex®, Exelon®, Razadyne® and Namenda®). These drugs offer some relatively short-term symptomatic relief, but do not treat the underlying causes of the illness. Over the past decade, there has been an intense research effort both in the non-profit sectors such as universities, government agencies and research institutes and in the pharmaceutical and biotechnology industry to develop new treatments for Alzheimer’s disease. Treatment candidates under development include: vaccines and other immunotherapies for Alzheimer’s disease. A number of pharmaceutical and biotechnology companies including Merck, Johnson & Johnson, Novartis, and Baxter are working on Alzheimer’s disease therapies.Johnson & Johnson, Roche, Merck, and Bristol-Myers Squibb are working on Alzheimer’s disease therapies.drugs targeting the tau protein which forms tangles in brain cells of Alzheimer’s disease patient. A number of pharmaceutical and biotechnology companies including TauRx Therapeutics and Bristol-Myers Squibb are working on such therapies.drugs designed to enhance cognition from AstraZeneca and Roche among others. There is also ongoing research into possible methods of preventing Alzheimer’s disease such as taking certain cholesterol-lowering drugs called statins, certain diabetes drugs, estrogen replacement therapies, anti-oxidants such as vitamin E and ginkgo biloba, nutraceuticals such as resveratrol and docosahexanoic acid (DHA) (an omega 3 fatty acid), or 8


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anti-inflammatory drugs such as ibuprofen (e.g.,Advil® or Motrin®). The successful development of a treatment or method of preventing Alzheimer’s disease could significantly impact on our ability to develop or market a competing treatment for Alzheimer’s disease. Our treatments under development for enlarged prostate BPH face significant competition from existing products. There are eight drugs approved for treatment of BPH: four proprietary drugs (dutasteride (Avodart®), tamsulosin (Flomax®), alfusozin (Uroxatral®), and silodosin (Rapaflo®)), a combination of two drugs (dutasteride and tamsulosin) (JalynTM), and four generics (finasteride, terazozin, doxazozin, and prazosin). There are a number of thermal treatments on the market designed to shrink the enlarged prostate by heating its tissue with a device inserted through the urethra (the passage leading from the bladder through the penis through which men urinate). The devices on the market use microwave energy (Prostatron®, Targis Therapy® or TherMatrx®), low level radiowaves (TUNA System®), lasers (Indigo LaserOptic Treatment System® or Laserscope GreenLight PVPTM), direct heat, energy or hot water to heat or burn away prostate tissue. A variety of surgical procedures exist to surgically reduce or remove the prostate or to widen the urethra. These include procedures to cut away prostate tissue such as TURP (transurethral resection of the prostate) and using a resectoscope with an electrical loop inserted through the penis to cut the prostate tissue. A small device used to widen the constricted urethra called a prostatic stent can also be inserted. The diagnostic testing industry is also highly competitive. In the area of Alzheimer’s disease, Athena Diagnostics, Inc. markets diagnostic tests for different biochemical indicators found in blood and spinal fluid and for genetic predispositions for the illness. Other companies are attempting to develop and market other diagnostic products in this area. Amyvid® (florbetapir), a radioactive diagnostic agent for Positron Emission Tomography (PET) imaging marketed by Lilly, recently received FDA approval as an aid to the evaluation of patients with signs of Alzheimer’s disease. GE and Bayer are also developing similar technologies. The introduction of other diagnostics products for Alzheimer’s disease or tobacco product use that are cheaper, easier to perform, more accurate or otherwise more attractive to the physicians, health care payers or other potential customers would have a significant impact on the sales of our AlzheimAlertTM, NicAlertTM or TobacAlertTM products. We May Not Be Able to Successfully Market Our Products To increase our marketing, distribution and sales capabilities both in the United States and around the world, we will need to enter into licensing arrangements, contract sales agreements and co-marketing deals. We cannot assure you that we will be able to enter into agreements with other companies on terms acceptable to us, that any licensing arrangement will generate any revenue for the Corporation or that the costs of engaging and retaining the services of a contract sales organization will not exceed the revenues generated. Protecting Our Patents and Proprietary Information is Costly and Difficult We believe that patent and trade secret protection is important to our business, and that our success will depend, in part, on our ability to obtain strong patents, to maintain trade secret protection and to operate without infringing the proprietary rights of others. Obtaining and maintaining our patent position is costly. We pay for the filing, prosecution and fees of several hundred patents and patent applications in countries around the world, including the United States, Europe, Japan, Canada, Australia, New Zealand and South Korea. In the United States alone, Nymox has twenty-three patents issued or allowed relating to its technology. Our subsidiary, Serex, Inc. has eleven patents. While we believe that we have strong patent protection for the products we sell and for our product development programs and we are in the process of extending that patent protection to cover more countries or new discoveries or products, we cannot assure you that additional patents covering new products or improvements will be issued or that any new or existing patents will be of commercial benefit or be valid and enforceable if challenged. Many companies have patents covering various drugs, methods and discoveries in the fields of diagnostics and therapeutics for Alzheimer’s disease and related conditions and of new anti-infective agents. We believe that the patents issued to date should not preclude Nymox from developing and marketing our products; however, it is impossible to predict the extent to which licenses from third parties will be necessary. If Nymox were to need licenses from third parties there can be no assurance that we could obtain such licenses on commercially reasonable terms, if at all. In the fields of diagnostic methods and diagnostic tests for common human diseases and conditions, where Serex has many of its patents, there are many patents issued covering many areas of diagnostic methods, tests and technologies. We believe that these patents issued to date to other companies will not preclude Serex from developing and marketing its products but you should be aware that it is often difficult to determine the nature, breadth and validity of competing patent claims in these fields, that there has been significant litigation in some of these areas (not involving Serex) and that, if and when Serex’s products become more commercially successful, Serex’s products or patents may become the subject matter of litigation. If Serex were to need licenses from third parties there can be no assurance that it could obtain such licenses on commercially reasonable terms, if at all. We are not currently involved in patent litigation. In the pharmaceutical and biotechnology industry patent disputes are frequent and can preclude the commercialization of products. Patent litigation is costly and the outcome often difficult to predict. It can expose us to significant liabilities to third parties and may require us to obtain third-party licenses at a material cost or cease using the technology or product in dispute. 9


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We Face Changing Market Conditions The healthcare industry is in transition with a number of changes that affect the market for therapeutic and diagnostic test products. The U.S. federal and various state governments have under consideration a number of proposals that may have the effect of directly or indirectly limiting drug prices in the U.S. markets. In March 2010, the United States enacted health care reform legislation, the Patient Protection and Affordable Care Act. Important market reforms have begun and will continue through full implementation in 2014. The new law is expected to expand access to health care to more than 32 million Americans by the end of the decade. These changes may adversely affect the prices we may charge for any therapeutic drug we develop. Funding changes and budgetary considerations can lead major health care payers and providers to make changes in reimbursement policies for our products. These changes can seriously impact the potential for growth for the market for our products, either favorably when the decision is to offer coverage for our products at a reasonable price or negatively when the decision is to deny coverage altogether. Changes in the healthcare delivery system have resulted in consolidations and in the formation of multi-hospital alliances, reducing the number of institutional customers for therapeutic and diagnostic test products. There can be no assurance that Nymox will be able to enter into and/or sustain contractual or other marketing or distribution arrangements on a satisfactory commercial basis with these institutional customers. Health Care Plans May Not Cover or Adequately Pay for Our Products and Services Throughout the developed world, both public and private health care plans are under considerable financial and political pressure to contain their costs. The two principal methods of restricting expenditures on drugs and diagnostic products and services are to deny coverage or, if coverage is granted, to limit reimbursement. For single-payer government health care systems, a decision to deny coverage or to severely restrict reimbursement for one of our products can have an adverse effect on our business and revenues. In the United States, where, to a significant degree, the patient population for our products is elderly, Medicare and Medicaid are sources of reimbursement. In general, any restriction on reimbursement, coverage or eligibility under either program could adversely affect reimbursement to Nymox for products and services provided to beneficiaries of the Medicare and/or Medicaid programs. Many elderly people are covered by a variety of private health care organizations either operating private health care plans or Medicare or Medicaid programs subject to government regulation. These organizations are also under considerable financial constraints and we may not be able to secure coverage or adequate reimbursement from these organizations. Without coverage, we will have to look to the patients themselves who may be unwilling or unable to pay for the product; in turn, doctors may be reluctant to order or prescribe our products in the absence of coverage of the product for the patient. We Are Subject to Continuing Potential Product Liability Risks, Which Could Cost Us Material Amounts of Money We may be subject to product liability which could task our critical resources, delay the implementation of our business strategy, result in products being recalled or removed from the market, and materially and adversely harm our business and financial condition due to the costs of defending such legal actions or the payment of any judgments or settlements relating to such actions or both. Our business exposes us to the risk of product liability claims that is inherent in the development and marketing, distribution, and sale of pharmaceutical and diagnostic products. If any of our product candidates or marketed products harms people, or is alleged to be harmful, we may be subject to costly and damaging product liability claims brought against us by clinical trial participants, consumers, patients, health care providers, corporate partners or others. We have product liability insurance covering our ongoing clinical trials and marketed products. Our insurance coverage may not be sufficient to cover fully all potential claims, nor can we guarantee the solvency of any of our insurers. If our claims experience results in higher rates, or if product liability insurance otherwise becomes costlier because of general economic, market or industry conditions, then we may not be able to maintain product liability coverage on acceptable terms. If sales of our products increase materially, or if we add significant products to our portfolio, then we will require increased coverage and may not be able to secure such coverage at reasonable rates or terms. If our insurance coverage is not sufficient to cover fully all potential claims, the Corporation would be exposed to the risk that our litigation costs and liability could exceed our total assets and our ability to pay. The Issuance of New Shares May Dilute Nymox’s Stock The Corporation relies almost exclusively on financing to fund its operations. In order to achieve the Corporation’s business plan and realization of its assets and liabilities in the normal course of operations, the Corporation anticipates the need to raise additional capital and/or achieve sales and other revenue generating activities. The Corporation depends on financing under the Common Stock Private Purchase Agreement to fund its operations. Moreover, Nymox may use its shares as currency in acquisitions. The issuance of further shares and the eligibility of issued shares for sale will dilute our common stock and may lower its share price. There were 33,731,492 common shares of Nymox issued and outstanding as of March 15, 2013. In addition, 5,930,500 share options are outstanding, of which 5,890,500 are currently vested. Expiry dates for Nymox options range from 1 month to 9.6 years (see note 9(b) to our consolidated financial statements). These options have been granted to employees, officers, directors and consultants of the Corporation. We Face Potential Losses Due to Foreign Currency Exchange Risks Nymox incurs certain expenses, principally relating to salaries and operating expenses at its Canadian head office, in Canadian dollars. All other expenses are derived in U.S. dollars. As a result, we are exposed to the risk of losses due to fluctuations in the exchange rates between the U.S. dollar and the Canadian dollar. We protect ourselves against this risk by maintaining cash 10


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balances in both currencies. We do not currently engage in hedging activities. The Corporation may suffer losses as a result of unfavorable fluctuations in the exchange rates between the United States dollar and Canadian dollar. We Have Never Paid a Dividend and are Unlikely to do so in the Foreseeable Future Nymox has never paid any dividends and does not expect to do so in the foreseeable future. We expect to retain any earnings or positive cash flow in order to finance and develop Nymox’s business. ITEM 4. INFORMATION ON THE CORPORATION History of the Corporation Nymox Pharmaceutical Corporation was incorporated under the Canada Business Corporations Act in May, 1995 to acquire all of the common shares of DMS Pharmaceutical Inc., a private Corporation which had been carrying on research and development since 1989 on diagnostics and drugs for brain disorders and diseases of the aged with an emphasis on Alzheimer’s disease. Nymox has two subsidiaries: one wholly-owned subsidiary named Nymox Corporation and the other a majority owned subsidiary named Serex, Inc., acquired in 2000. Both subsidiaries are based in the same building in Hasbrouck Heights, New Jersey. Nymox Corporation conducts some research and development, while Serex conducts research and development, and some of the manufacturing for NicAlertTM and TobacAlertTM. Nymox’s principal executive offices are located at: Nymox Pharmaceutical Corporation 9900 Cavendish Boulevard, Suite 306, St. Laurent, Quebec, Canada, H4M 2V2 Phone: (800) 936-9669 Fax: (514) 332-2227 Nymox’s registered agent in the United States is: CT Corporation System 111 Eighth Avenue, 13thFloor New York, NY, 10011 Nymox’s two subsidiaries are located at: Nymox Corporation 777 Terrace AvenueHasbrouck Heights, NJ, USA 07604 Serex, Inc. 777 Terrace AvenueHasbrouck Heights, NJ, USA 07604 Nymox Pharmaceutical Corporation is a biopharmaceutical Corporation with three proprietary products on the market, and a significant R&D pipeline of products in development for the treatment of such conditions and diseases as enlarged prostate (benign prostatic hyperplasia or BPH), Alzheimer’s disease (AD), E. coliO157:H7 contamination of food and drink products, and bacterial infections and for the diagnosis of AD and other indications. Nymox also has U.S. and global patent rights for the use of statin drugs for the treatment and prevention of Alzheimer’s disease. Acquisition of a Majority Interest in Serex, Inc. In March 2000, we acquired a controlling interest in Serex, Inc., a privately held diagnostic Corporation based in New Jersey and now own approximately 99% of its common stock. Serex’s patented diagnostic technologies include its particle valence technology, a highly sensitive, new method to detect very small amounts of biochemical indicators in body fluids such as blood, urine and saliva. This technology can be adapted to detect a wide range of biochemical indicators for diseases, conditions and drug use. Our NicAlertTM and TobacAlertTM employ this technology to measure levels of one of the metabolic products of nicotine in human urine, in order to determine whether a person is using or has been exposed to a tobacco product. NicAlertTM and TobacAlertTM are currently being distributed by Nymox and by third party distributors, including Jant Pharmacal Corporation. Products NicAlertTM for Tobacco Product Use and TobacAlertTM for Second-Hand Smoke Exposure Nymox has developed and markets NicAlertTM and TobacAlertTM, which are inexpensive, simple-to-use test strips for determining whether a person is using tobacco products (NicAlertTM) or has been recently exposed to second-hand smoke (TobacAlertTM). Both NicAlertTM and TobacAlertTM employ Serex, Inc.’s patented technology to provide an accurate read-out of levels of cotinine, a by-product of the body’s breakdown of nicotine and generally regarded as the best indicator of tobacco 11


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exposure for smokers and nonsmokers. The technology can be used with saliva as well as urine samples in order to detect tobacco product use. NicAlertTM and TobacAlertTM do not require instruments or special training to use and offer a quick, convenient means to test on-site whether a person, such as a child, teenager, student athlete or insurance applicant, is using a tobacco product or has been exposed to second-hand smoke. Smoking and other tobacco product use is a serious public health problem around the world. Smoking kills. According to the Centers for Disease Control and Prevention, cigarette smoking is responsible for more than 443,000 deaths per year in the United States alone. Smoking can cause cancer of the lung, mouth, bladder, larynx, esophagus and other organs, as well as heart disease and stroke and chronic lung disease. Every year, exposure to second-hand smoke (environmental tobacco smoke or ETS) causes an estimated 3,400 nonsmoking Americans to die of lung cancer and up to 300,000 American infants and small children to suffer from lower respiratory tract infections. NicAlertTM received clearance from the FDA in October 2002 for medical use to determine if an individual has been exposed to tobacco products. In January, 2006, Nymox announced the certification of the urine-based version of NicAlertTM with a CE Mark making it eligible for sale in the European Union and in May, 2006 the certification of the saliva-based version of NicAlertTM with a CE Mark. In September, 2003, Nymox launched TobacAlertTM for nonmedical testing for second hand smoke exposure in the U.S. We market the NicAlertTM and TobacAlertTM tests through our own marketing arm and distributors in North America, Europe and Asia. TobacAlertTM is also available online at www.tobacalert.com. Nymox has entered into distribution and marketing agreements with companies and organizations in the U.S. and the U.K. for these products. Our NicAlertTM and TobacAlertTM products face competition from clinical laboratories such as LabCorp and Quest Diagnostics which provide off-site lab testing for cotinine, the by-product of the body’s breakdown of nicotine measured by NicAlertTM and TobacAlertTM, and from assay suppliers, including immunoassay developers such as OraSure Technologies Inc. and Abraxis LLC, and diagnostic system manufacturers such as Roche Diagnostics, Abbott and Diagnostic Products Corporation. NicAlertTM and TobacAlertTM also face competition from distributors who supply yes-no smoking status tests such as NicQuick, and QuickScreen, from NicCheck I, an FDA-cleared smoking status test being marketed by Mossman & Associates Ltd, from SmokeScreen, a chemical color-based tobacco test being marketed by Mermaid Diagnostics, Ltd. in the United Kingdom, and from carbon monoxide (CO) monitors such as SmokeCheck. NicAlertTM and TobacAlertTM products are currently partly manufactured through out-sourcing arrangements with contract manufacturers. To date, we have not experienced any significant interruptions in the manufacture of these products and the cost of the manufacturing services has not been volatile. The manufacturing services supplied by our current contract manufacturers are not unique or unduly complicated and other contract manufacturers are available to provide similar services in the event that our current contract manufacturers fail to meet our needs. The technology used in these products is covered by patents and patent applications held by Nymox's subsidiary, Serex, Inc., both in the U.S. and elsewhere in the world with expiry dates no earlier than April 2013. Independent studies published in peer-reviewed medical and scientific journals reported finding that the Corporation's NicAlertTM Saliva product provides an accurate, convenient and cost-effective way to verify self-reported smoking status with broad potential applications both in the clinic and in large research trials and surveys. In 2008, one such study, Fiona Cooke et al. “Diagnostic accuracy of NicAlert cotinine test strips in saliva for verifying smoking status,” Nicotine Tob Res.2008;10:607-12, was published in Nicotine & Tobacco Research, the official journal of the Society for Research on Nicotine and Tobacco (SRNT). Other published studies include Hum Psychopharmacol.2010 25(1): 80–83, Cancer Epidemiol Biomarkers Prev.2007; 16:1858-62 and Int J Circumpolar Health.2007; 66 Suppl 1:29-38. NicAlertTM Saliva was also reported used in research studies where there was a need to verify or monitor smoking status or nicotine replacement therapy (NRT): see, for example, Am J Prev Med.2007; 33:297-305 (monitoring NRT in smoking cessation research involving pregnant women), Int J Behav Med.2006; 13:16-25 (verifying smoking status in a smoking study of cancer patients), and Neuropsychopharmacology2008; 33:480–490 (confirming non-smoking status for entry into the study). AlzheimAlert TM; an Aid to the Diagnosis of Alzheimer’s Disease We have developed AlzheimAlertTM, a proprietary urine assay that can aid physicians in the diagnosis of Alzheimer’s disease. We have developed a kit version of the AlzheimAlertTM assay for sale in Europe. The AlzheimAlertTM kit has the CE Mark. The kit allows clinical reference laboratories to perform the AlzheimAlertTM assay on site with urine samples sent directly to the laboratory. We filed a premarket approval (PMA) application for the diagnostic kit version of the AlzheimAlertTM test with the FDA in February 2004. On July 15, 2005, an FDA advisory panel voted 5-2 against approval of the kit, citing the need for further studies, such as long term follow-up and autopsy confirmation. The AlzheimAlertTM assay is based on research by scientists at the Massachusetts General Hospital and Brown University and on years of clinical studies to establish and confirm the accuracy of the assay technology as an aid to the diagnosis of Alzheimer’s disease. In 1997, Nymox succeeded in developing a commercial assay that used spinal fluid samples. Subsequently, Nymox was able to develop an assay that used more easily obtained first morning urine samples. The AlzheimAlertTM assay represents the latest generation of development of this testing technology. 12


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Nymox licensed the technology that led to the development of the AlzheimAlertTM assay in 1997 from the Massachusetts General Hospital as part of a sponsored research and licensing agreement, under which Nymox sponsored the research of the principal investigators into the use of neural thread protein (“NTP”), its antibodies or genes for diagnostic or therapeutic purposes. Nymox also paid the patent costs for the patent applications filed arising out of this research. In return, Nymox received an exclusive worldwide license of the patents to sell products and to use processes encompassed by them. Nymox is to pay the Massachusetts General Hospital a 4% royalty of the net sales price of any product developed and sold under the license. Nymox currently pays this royalty on its sales of its AlzheimAlertTM product. The license and the obligation to pay patent costs and royalties continue for the life of the patents, which run until 2015 at the earliest. The Massachusetts General Hospital has the right to terminate the license in any country where, after the first commercial sale of the product in the country, there is a continuous two year period in which no product is sold in such country. There are eight issued U.S. patents under license and a larger number of patents and patent applications in Europe, Japan, Canada, Australia, New Zealand and South Korea. The sponsored research portion of this agreement terminated in March 1999. Nymox retained the exclusive license to the rights to the AlzheimAlertTM-related patents owned by the Massachusetts General Hospital. Effective March 1999, Nymox entered into a similar sponsored research and licensing agreement with Brown University and the Rhode Island Hospital. Under the terms of this agreement, Nymox continued to sponsor research into the uses of NTP, their antibodies or genes for diagnostic, therapeutic and research purposes and to pay the patent costs for any patent applications filed arising out of this research. In return, Nymox received an exclusive worldwide license of any such patents to sell products and to use processes encompassed by them. The Rhode Island Hospital has the right to terminate the license in any country where, after the first commercial sale of the product in the country, there is a continuous two year period in which no product is sold in such country. Nymox is to pay the Rhode Island Hospital a 4% royalty of the net sales price of any product developed and sold under the license. The sponsorship of this agreement expired in March 2005; however, Nymox retains the exclusive license to patent rights on certain NTP-based technology including a license to two issued U.S. patents. Nymox believes that its AlzheimAlertTM test can assist a physician faced with the task of diagnosing whether a patient has Alzheimer’s disease. An independent peer-reviewed double blind study from 8 prestigious centers across the U.S. found the level of accuracy of the AlzheimAlertTM urine test to be over 90% (Journal of the American Medical Directors AssociationJan 2007; 8:21-30; “A multi-center blinded prospective study of urine NTP measurements in patients with suspected Alzheimer's disease,” Goodman I et al.). This study confirmed several earlier Corporation funded trials of the AlzheimAlertTM technology. In earlier studies, the test results were positive for over 87% of the patients with verified Alzheimer disease and negative in over 89% of subjects without the disease (known as a low false positive rate). The low rate of positive results for patients without the disease is important for doctors investigating patients with subtle or marginal symptoms of mental, emotional, cognitive, or behavioral changes. If the doctor can rule out Alzheimer’s with more assurance, a great deal of patient and family anguish and anxiety will be avoided. A low test score will help the doctor to be more certain that Alzheimer’s disease is not the cause of the patient’s symptoms and to target the other, often reversible causes of the patient’s symptoms, such as depression. There can be no assurance that further studies will repeat the same level of success experienced to date. In January 2007, a second peer-reviewed report was published in the Journal of Clinical Laboratory Analysisproviding further positive data on the accuracy and utility of the Corporation's urinary AlzheimAlertTM test (J Clin Lab Anal.Jan 2007;21:24-33, “Competitive ELISA studies of NTP in urine in Alzheimer's disease”). The paper reported excellent performance in laboratory studies and impressive reproducibility of clinical test results for patients and controls who were re-tested at intervals ranging from 2 days to 4.5 years. Some publications in the peer-reviewed literature concerning the clinical utility of the assay in the diagnosis of Alzheimer’s disease include, for example, the Journal of Clinical Investigation(1997; 100: 3093-3104); Journal of Contemporary Neurology(1998; art. 4a); Journal of Clinical Laboratory Analysis(1998; 12: 285-288) and (1998; 12: 223-226); Alzheimer’s Reports(1999; 2: 327-332), (2000; 3: 177-184), (2001; 4: 61-65) and (2002; 5: 1-6); Neurology(2000; 54: 1498-1504) and (2000; 55: 1068); Journal of Alzheimer’s Disease(2001; 3: 345-353) and (2004; 6(3): 231-42); Cellular and Molecular Life Sciences(2001; 58: 844-849) and (2003; 60: 2679-91); Neurology and Clinical Neurophysiology(2002; 1: 2-7); Journal of Neuropathology and Experimental Neurology(2001; 60: 195-207) and (1996; 55: 1038-1050), Frontiers in Bioscience(2002; 7: d989-96), Journal of the American Medical Directors Association(2007; 8:21-30), Journal of Clinical Laboratory Analysis(Jan 2007;21:24-33), Expert Review of Molecular Diagnostics(2008; 8:21-28) and Journal of the American Medical Directors Association(2011; 12(5):372-6). There is a large need for a simple, non-invasive test that can aid in the diagnosis of Alzheimer’s disease. According to 2012 Alzheimer’s Disease Facts and Figures, U.S. Alzheimer’s Association, Alzheimer’s disease is the most common cause of dementia and is the sixth leading cause of death in the United States. It is estimated that as many as 5.4 million people have Alzheimer's disease in the United States alone. By 2050 this number is projected to increase to between 11 and 16 million Americans. The annual national direct and indirect costs of caring for Alzheimer patients in the U.S. alone are estimated to be $200 billion a year and rising. The human toll on patients, families and caregivers is incalculable. Despite the need for an accurate clinical test, the definitive diagnosis of the disease is possible only after the death of the patient by expert, pathologic examination of brain tissue. The U.S. Surgeon General’s Report on Mental Health, released on December 13, 1999, identified the importance and the need for the early detection and diagnosis of Alzheimer’s disease. The report described the current approach to Alzheimer’s disease diagnosis, clinical examination and the exclusion of other common causes of its symptoms, as time- and labor-intensive, costly and largely dependent on the expertise of the examiner. As a result, the illness is currently under-recognized, especially in primary care settings, where most older patients seek care. The report joined other experts writing in the field in recognizing the need for a better, more reliable method for diagnosing the disease in living patients and in particular, the need for a simple, 13


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accurate and convenient test that could detect a biochemical change early in patients with Alzheimer’s disease. We believe our AlzheimAlertTM product provides such a test. The early diagnosis of Alzheimer’s disease is important to physicians, patients and their families and enables them to make informed and early social, legal and medical decisions about treatment and care. Early diagnosis of Alzheimer’s disease has become increasingly important with new improvements in drug treatment and care. Even a modest delay in institutionalization can mean substantial social and financial savings. Conversely, any testing procedure that could rule out Alzheimer’s disease would eliminate the tremendous uncertainty and anxiety patients and their families otherwise face and would allow physicians to focus on the other, often reversible, causes of cognitive changes. Early diagnosis as facilitated by the AlzheimAlertTM test represents a potentially large cost-savings in the form of a reduced number of office visits, lab tests, scans and other procedures required by the traditional methods of diagnosis. In the field of Alzheimer’s disease diagnosis, our AlzheimAlertTM test faces growing competition which could detrimentally impact on our ability to successfully market and sell our diagnostic test. Our competitors include: Eli Lilly and Company, which is currently marketing Amyvid® (florbetapir), a radioactive diagnostic agent for Positron Emission Tomography (PET) imaging, which is used to estimate the density of neuritic plaques in patients being evaluated for Alzheimer’s disease.Athena Diagnostics, Inc., which is currently marketing three tests claimed to aid in the diagnosis of Alzheimer's disease: a genetic test for the rare cases of familial, early-onset Alzheimer's disease; a genetic test for a relatively common mutation of a gene said to increase the likelihood of a person with at least one of the genes contracting the disease; and a test for two proteins in the spinal fluid of patients.Innogenetics NV, which currently markets tests and kits for two proteins and a variant of one of these proteins in the spinal fluid of patients and a genetic test for a relatively common mutation of a gene said to increase the likelihood of a person developing the disease.Amorfix Life Sciences Ltd., which currently markets a research test to detect aggregated amyloid protein in brain test and has under development related blood and CSF tests. There are also a number of other proposed biochemical signs of the disease that could potentially be developed into a commercial diagnostic test as well as various scanning and imaging technologies which compete for a portion of the diagnostic market for Alzheimer’s disease. A number of companies, including GE and Bayer, are actively working to develop imaging technologies for the diagnosis of Alzheimer’s disease. In June 2004, the CMS approved limited coverage of a Positronic Emission Tomography (PET) imaging procedure for helping to more precisely distinguish Alzheimer's disease from a rarer type of dementia when clinical evaluation has been inconclusive. In October 2004, the National Institute on Aging in conjunction with other Federal agencies, private companies and organizations launched the Alzheimer’s disease Neuroimaging Initiative, a $60 million initiative to test whether various scanning and imaging technologies, biochemical markers, and clinical and neuropsychological testing can be combined to help diagnose early Alzheimer’s disease. Products in Development: NX-1207 for Enlarged Prostate (BPH) We are developing treatments for BPH, using novel compounds. Our lead candidate NX-1207, which successfully completed a multi-center, double-blind, placebo-controlled Phase 2 trial in September 2006, is presently in Phase 3. We cannot predict with any certainty the outcome of this trial, what further steps may be required in order to apply for final FDA approval for this drug or whether the FDA will ultimately grant us such approval. There is a significant need for an effective treatment for BPH. More than half of men in their sixties and as many as 90% of men in their seventies and eighties have the symptoms or signs of BPH according to the 2010 AUA Guideline on the Management of Benign Prostatic Hyperplasia, American Urological Association. Symptoms include more frequent urination (especially at night), difficulty urinating, incomplete emptying of the bladder and sometimes complete inability to urinate. More serious cases may require surgical intervention to reduce the size of the prostate. There is a need for a simple, effective treatment for BPH, particularly in cases where existing drug treatments have proven to be ineffective and where more intrusive procedures such as surgery may be inadvisable or bring unacceptable risks. In July 2012, Nymox reported positive results from a new study of long-term treatment outcomes for men who had received a single injection of NX-1207 2.5 mg for treatment for their BPH. The study analysis found that a statistically significant greater number of men who had received NX-1207 2.5 mg reported positive treatment outcomes as compared to men who had received a placebo. The study involved the latest available blinded follow-up study data (an average of 57 months post-injection) from the completed clinical trials for these treatment groups. A positive treatment outcome was seen if the patient was not using other BPH medications and no surgical treatment (including MIST) for BPH was reported at any time during the post-injection follow-up period. The combined new statistical analysis of blinded study data showed NX-1207 2.5 mg to have a lasting benefit in terms of positive treatment outcomes that was significantly superior to placebo. Previous follow-up studies have shown long-term benefit from a single NX-1207 treatment in excess of 5 years in some cases. Completed Phase 2 studies have shown that a single administration of NX-1207 resulted in symptomatic improvements which reached statistical significance compared to double-blinded placebo and study controls. Patient-reported improvements in the 14


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standardized BPH symptom score were on average 8 to 10 points at 90 days as compared to the approximately 3 to 5 points reported on average for currently approved BPH drugs. The drug is administered by a urologist in an office setting in a brief procedure that does not require anesthesia, sedation, or catheterization and involves little or no pain or discomfort. NX-1207 treatment has not been found to have the sexual, blood pressure, or other side effects associated with the use of the approved drugs for the treatment of BPH. Follow-up studies have shown clinical efficacy effects lasting up to 71⁄2 years after a single treatment. In February 2009, the Corporation reported concluding a positive and productive EOP2 meeting with the FDA concerning the Phase 3 program for NX-1207. In June 2009, the Corporation began conducting the first of two pivotal double blind placebo controlled Phase 3 trials for NX-1207 that incorporate the specific protocol design recommendations provided to the Corporation by the FDA. The two pivotal Phase 3 studies for NX-1207 are being conducted at well-known investigational sites across the U.S. with planned enrolment of 1,000 patients. In July 2012, Nymox announced the completion of enrollment for the Phase 3 repeat injection Study NX02-0020. The NX02-0020 study started in July 2011 and involved men who had previously participated in one of the earlier Nymox NX-1207 studies for BPH. On January 22, 2013, Nymox announced the completion of the six month primary endpoint evaluating safety for the NX02-0020 study and reported that the safety assessment was positive with no reported significant adverse events related to the drug and none of the reported sexual, cardiovascular, or other side effects that are associated with approved BPH medications. On November 28, 2012, Nymox announced completion of patient enrollment in the Corporation’s pivotal U.S. Phase 3 NX02-0017 Study of NX-1207 for BPH. Our treatments under development for enlarged prostate (benign prostatic hyperplasia or BPH) face significant competition from existing products. There are nine drugs approved for treatment of BPH: five proprietary drugs (dutasteride (Avodart®), tamsulosin (Flomax®), alfusozin (Uroxatral®), and silodosin (Rapaflo®)) a combination of two drugs (tadalafil (Cialis®), dutasteride and tamsulosin) (JalynTM), and four generics (finasteride, terazozin, doxazozin, and prazosin). There are a number of thermal treatments on the market designed to shrink the enlarged prostate by heating its tissue with a device inserted through the urethra (the passage leading from the bladder through the penis through which men urinate). The devices on the market use microwave energy (Prostatron®, Targis Therapy® or TherMatrx®), low level radiowaves (TUNA System®), lasers (Indigo LaserOptic Treatment System® or Laserscope GreenLight PVPTM), direct heat or hot water to heat or burn away prostate tissue. A variety of surgical procedures exist to surgically reduce or remove the prostate or to widen the urethra. These include procedures to cut away prostate tissue such as TURP (transurethral resection of the prostate) and using a resectoscope with an electrical loop inserted through the penis to cut the prostate tissue. A small device used to widen the constricted urethra called a prostatic stent can also be inserted. NX-1207 for Prostate and Liver Cancer We are also developing NX-1207 as a focal treatment for certain types of cancer. On August 26, 2009, Nymox announced that NX-1207 has been shown to produce strongly positive results when given to animals with hepatocellular carcinoma (HCC). In the experimental studies, the cancers were significantly reduced in size after 2 local injections of NX-1207. On October 14, 2009, we announced that NX-1207 had been shown to produce strongly positive results in laboratory studies of human prostate cancer. In addition, local injection of NX-1207 showed activity in animals with transplanted human prostate carcinoma. The NX-1207 used in these studies is a higher dosage from that of NX-1207 used to treat BPH. The Corporation intends to advance NX-1207 into human clinical trials for the treatment of HCC and for the focal treatment of localized prostate cancer. We cannot predict with any certainty whether the use of NX-1207 for any oncological indication will successfully complete preclinical testing, whether government regulatory agencies, such as the FDA, will permit such products to proceed to human trials, or whether ultimately the use of NX-1207 for any such indications will be granted approval for sale and marketing in the U.S., Canada, or elsewhere in the world. The development of cancer therapeutics in particular is associated with high risks and many uncertainties and a drug candidate that shows efficacy in pre-clinical testing and in animal models may fail in human trials or take a long period (7 years or more) to achieve regulatory approval. On March 1, 2012, Nymox announced the initiation of a Phase 2 U.S. clinical trial to evaluate the Corporation’s NX-1207 drug for the treatment of low grade localized prostate cancer in accordance with an Investigational New Drug (IND) application filed with the FDA and specific direction and guidance provided by the FDA in Pre-IND meetings. Preclinical studies of NX-1207 have shown activity against prostate cancer cells at higher dosage levels of NX-1207 than the dosage used in the current Phase 3 BPH clinical trials. The clinical trial (NX03-0040) is currently enrolling men in a two dose 6 week Phase 2 study designed to test both low and high doses of NX-1207 for their effect on low grade localized prostate cancer in 150 subjects. NXC-4720 for E. coli Contamination of Meat We are developing novel antibacterial agents for the treatment of E. coliO157:H7 bacterial contamination in hamburger meat and other food and drink products and for the treatment of urinary tract and other bacterial infections in humans which have proved highly resistant to conventional antibiotic treatments. E. colicontamination of food and drink is a serious public health problem worldwide and a major concern for meat processors in particular. E. colibacteria occur normally and usually harmlessly in the gastrointestinal tracts of humans, cows and other animals. However, one mutant variety of the E. coli bacteria, E. coliO157:H7, can cause life-threatening illness and has been 15


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implicated in cases of severe diarrhea, intestinal bleeding and kidney failure, leading, in some cases, to death in children and the elderly. E. colicontamination in hamburger meat and other food products and in drinking water affects about 70,000 people in the United States a year. There is a well-recognized need in the beef industry to address the problem of E. colicontamination in meat processing and in livestock. E. colicontamination has triggered massive recalls of ground beef in the U.S. Cattle are a natural reservoir for the deadly strain of E. coli. Water contamination from cattle operations have led to public health tragedies. Nymox developed a potent new antibacterial agent, NXC-4720. Tests of NXC-4720 show it to be highly effective against all known substrains of E. coliO157:H7, destroying the bacteria efficiently, rapidly and at a very low dose. In 1999, we began further laboratory trials for this agent as a treatment for food and drink contamination and entered into agreements with various collaborators. NXC-4720, which is being developed as a treatment of meat at the processing stage, has been shown to be capable of substantially reducing the level of potentially fatal E. coliO157:H7 contamination on fresh beef according to laboratory studies. Other projects in this area, such as treating E. coliO157:H7 infection in livestock, are in preliminary stages of development. Further pre-clinical testing and development is required before we can apply for regulatory approval for use of this agent on the processing of food and drink for human consumption. The problem of E. coliO157:H7 contamination of hamburger meat and other food products is also well-known and a number of companies and researchers have been pursuing various potential solutions, including irradiation with x-rays, better detection of contamination, electronic pasteurization, vaccination and competitive exclusion of the pathogenic E. colibacteria by harmless bacteria. The development of alternative solutions to the problem of E. coli infection may adversely affect the market for our treatment for E. coliO157:H7 infection in cattle and contamination of food products. Nymox has also developed three other novel antibacterial agents, NXB-4221 for the treatment of difficult chronic and persistent urinary tract infections; NXB-5886 for the treatment of streptococcal infection; and NXT-1021 for the treatment of staphylococcal infection. Urinary tract infections in women caused by bacteria such as E. coliare a common and significant infection often resistant to conventional antibiotic treatment. Some varieties of streptococcus and staphylococcus bacteria, a common source of infection in humans, have acquired a broad immunity to antibiotic treatments. Infections from these antibiotic resistant bacteria are difficult to treat and can be life threatening. Nymox’s three antibacterial agents for the treatment of infectious disease have all shown the ability to kill their bacterial targets in culture with no signs of toxicity. Further pre-clinical testing and development is required before we can apply for regulatory approval to begin initial testing in humans. A similar competitive reality prevails in the field of novel anti-infectives. Over the past ten years, there has been an increasing awareness of the medical need and of emerging market opportunities for new treatments for antibiotic resistant bacterial infections. Many of the major pharmaceutical companies are developing anti-infective drugs that either modify their existing drugs or involve new anti-bacterial properties. Many biotechnology companies are developing new classes of anti-bacterial drugs. At least three major pharmaceutical companies have vaccines against bacterial infections in development. To the extent that these companies are able to develop drugs or vaccines that offer treatment for some or all of the indications for our anti-infectives, the market for our products may be adversely affected. Nymox has patent rights to these and other antibacterial agents. The Use of Statin Drugs for the Treatment or Prevention of Alzheimer’s Disease In October 2002, we were issued a United States patent for the use of statin drugs to treat, prevent or reduce the risk of the onset of Alzheimer’s disease and have issued patents or pending patent applications elsewhere, including Europe, Japan, Canada and Australia. Statins are a class of commonly prescribed cholesterol lowering drugs that have a well-established safety record and are widely available. The potential of statin drugs for AD has been featured in a cover story in Newsweek, as well as in the New York Times, Fortune, Los Angeles Times, and The Wall Street Journal.Some of the scientific studies and reviews concerning the potential for statin drugs to treat or reduce the risk of AD or loss of cognitive function include Neurology.2007; 69:1873-80; Expert Opinion on Ther Targets.2007; 11:1257-60; CNS Drugs.2007;21:449-62; Neurosci Lett.2007;416:279-84; Curr Med Chem.2007;14:103-12; Neurol Res.2006; 28:630-6, Acta Neurol Scand2006; 114 (Suppl. 185): 78-86, Acta Neurol Scand2006; 114 (Suppl. 185): 3–7, J.Neurochem.2006; 97:716-723; Restor. Neurol. Neurosci2006; 24:79-95; Neuromolecular Med.2006; 8:319-328, Neurology2005; 65:1388-1394, J. Neurol. Neurosurg. Psychiatry2005; 76:1624-1629, The American Journal of Medicine2005; 118: 48S-53S; The Lancet Neurology2005; 4:841-852; Current Opinions in Lipidology2005;16: 619-623; The Lancet Neurology2005; 4: 521-2, Arch Neurol2005; 62:1047-51, Neurology2005; 64:1531-8, Arch Neurol2005; 62:753-7, J Neurol Sci2005; 229-230:147-50, Arch Gen Psychiatry2005; 62:217-24. International Journal of Geriatric Psychiatry(2004; 19:327-32), Neuroepidemiology(2004; 23:94-8); Neuron(2004; 41:7-10); Archives of Neurology(2000; 57:1439-1443); Lancet(2000; 356:1627-1631); Archives of Neurology(2002; 59:223-227); Journals of Gerontology: Biological Sciences and Medical Sciences(2002; 57:M414-M418); and Journal of the American Geriatrics Society(2002;50:1852-1856). Some studies, however, have not found evidence that statins may help treat or prevent Alzheimer’s disease and research in this area is ongoing. No statin drug has been approved for use in the treatment or prevention of Alzheimer’s disease. 16


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Research and Development of New Products New Therapeutics for Alzheimer’s Disease Nymox has a number of proprietary drug development programs aimed at treatments for Alzheimer's disease and other indications. One program targets NTP and its role in the extensive brain cell loss associated with AD. Another program is based on spherons, which Nymox researchers regard as a source of senile plaques, the characteristic abnormality found in abundance in the brains of patients with AD and widely believed to play a major role in the cause and course of the illness. A third program is based on a novel drug candidate, NXD-5150, for neurodegenerative disease. At present, there is no cure for Alzheimer’s disease. There are five drugs approved by the FDA, tacrine (brand-name Cognex®), donepezil HCI (brand-name Aricept®), rivastigmine (brand-name Exelon®), galantamine hydrobromide (brand name Razadyne®) and memantine (brand name Namenda®) for the treatment of Alzheimer’s disease. However, at most these drugs offer symptomatic relief for the loss of mental function associated with the disease and possibly help to delay the progression. There is no consensus as to the cause of Alzheimer’s disease or even whether it is one disease or many. The Alzheimer’s Association’s 2012 Alzheimer’s Disease Facts and Figuresestimates that the healthcare payments for people with Alzheimer’s disease will total $200 billion in 2012 and that the economic value of unpaid care for people with Alzheimer’s disease was over $210 billion in 2011. These costs are expected to rise sharply as the baby boom generation ages and more people become at risk for the disease. According to the National Institute on Aging’s 2009 Progress Report on Alzheimer’s Disease: Discovery and Hope, experts agree that the number of people with AD will increase significantly if current population trends continue and no preventive treatments become available. As people live longer, they become more at risk of developing Alzheimer’s disease. The U.S. Census Bureau projects that the number of people in the U.S. aged 65 will double to about 72 million people by 2035 with the 85-and-older group being the fastest growing segment of the U.S. population by then. Nymox’s research into drug treatments for Alzheimer’s disease is aimed at compounds that could arrest the progression of the disease and therefore are targeted for long term use. Drugs Targeting Spherons We are a leader in research and development into drugs for the treatment of Alzheimer’s disease that target spherons. Nymox researchers believe that spherons are a cause of senile plaques, the characteristic lesion found abundantly in the brains of patients with Alzheimer’s disease and believed by many researchers to play a pivotal role in the fatal illness. Spherons are tiny balls of densely packed protein found in brain cells scattered throughout the brains of all humans from age one. Nymox researchers have found that as humans age the spherons grow up to a hundred times larger until they become too large for the cells that hold them. Once released from the cells, the researchers believe that the spherons burst, creating senile plaques, contributing to the cellular damage and biochemical changes pivotal to the symptoms and signs of Alzheimer’s disease. The substantial evidence linking spherons to senile plaques and Alzheimer’s disease has been published in journals such as the Journal of Alzheimer’s Disease, Drug News & Perspectivesand Alzheimer Reports. There are 20 important criteria of validity which have been set forth correlating the disappearance of spherons in old age with the appearance of senile plaques and implicating spherons as a major cause in Alzheimer’s disease. In 2000, Nymox researchers published important findings in Alzheimer Reports(2000; 3: 177-184) confirming that spherons contain key proteins that are also known to be in senile plaques and showing that, like senile plaques, spherons contain unusually old proteins in terms of the human body’s metabolism, with an average age of 20 to 40 years. In 2003, Nymox announced the discovery that spherons contain toxic molecules termed spherotoxins which its researchers believe contribute significantly to the cell death and symptoms characteristic of Alzheimer's disease. Nymox researchers believe that stopping or inhibiting the transformation of spherons into senile plaques will help stop or slow the progress of this illness. However, there is no consensus among researchers about the causes or possible treatments of Alzheimer’s disease and not all researchers share this belief that spherons are a causative factor in Alzheimer’s disease or are a target for the development of treatments for the disease. Based on the research findings discussed above and the spheron-based approach to the treatment of the disease, we have developed novel, proprietary drug screening methods based on spherons and used them to discover, develop and test drug candidates to inhibit the formation of Alzheimer plaques from spherons. We believe these candidates have the potential to slow or stop the progression of the disease. Such drug candidates will require regulatory approval in order to begin clinical studies for humans, but there is no guarantee that any of these drug candidates will ever be approved for marketing as a treatment for Alzheimer’s disease. Drug candidates that look promising in early studies in the laboratory or with animals often prove on further testing to be unsafe, ineffective or impractical to use with human patients. The cost of bringing a drug candidate through the necessary clinical trial and regulatory approvals is very high and may require us to seek substantial financing through various sources including the issuing of more stock, the borrowing of funds secured by financial instruments such as bonds or agreements with major pharmaceutical companies. We risk not being able to secure such funding in the necessary amounts or on sufficiently favorable terms. 17


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Nymox holds global patent rights covering both methods for using spherons as targets for developing drugs and for the actual drug candidates discovered. Neural Thread Protein Based Drugs Nymox developed a drug screening system, based on the research that led to its AlzheimAlertTM test, to identify other potential drug candidates for the treatment of Alzheimer’s disease. There is a substantial body of evidence showing that NTP may play a key role in Alzheimer’s disease, including such published studies as Journal of the Neurological Sciences(1996; 138: 26-35), Journal of Neuropathology and Experimental Neurology(1996; 55: 1038-50) and (2001; 60: 195-207), Journal of Clinical Investigation(1997; 100: 3093-3104), Alzheimer’s Reports(1999; 2: 327-332), Journal of Alzheimer’s Disease(2001; 3: 345-353) and (2005; 7(1): 45-61), and Cellular and Molecular Life Sciences(2001; 58: 844-849) and (2003; 60:2679-91). Nymox licensed the NTP technology in 1997 from Harvard University and the Massachusetts General Hospital as part of a sponsored research and licensing agreement. Under the terms of this agreement, Nymox sponsored the research of the principal investigators into the use of NTP, its antibodies or genes for diagnostic or therapeutic purposes. Nymox also paid the patent costs for the patent applications filed arising out of this research. In return, Nymox received an exclusive worldwide license of the patents to sell products and to use processes encompassed by them. Nymox is to pay the Massachusetts General Hospital a 4% royalty of the net sales price of any product developed and sold under the license. Nymox currently pays this royalty on its sales of its AlzheimAlertTM product. The license and the obligation to pay patents costs and royalties continue for the life of the patents, which run until November, 2014 at the earliest. The Massachusetts General Hospital has the right to terminate the license in any country where, after the first commercial sale of the product in the country, there is a continuous two year period in which no product is sold in such country. There are eight issued U.S. patents under license and a larger number of patents and patent applications in Europe, Japan, Canada, Australia, New Zealand and South Korea. The sponsored research portion of this agreement terminated in March, 1999. Nymox retained the exclusive license to the rights to the NTP-related patents owned by the Massachusetts General Hospital. Effective March 1999, Nymox entered into a similar sponsored research and licensing agreement with Brown University and the Rhode Island Hospital. Under the terms of this agreement, Nymox continued to sponsor research into the uses of NTP, their antibodies or genes for diagnostic, therapeutic and research purposes and to pay the patent costs for any patent applications filed arising out of this research. In return, Nymox received an exclusive worldwide license of any such patents to sell products and to use processes encompassed by them. The Rhode Island Hospital has the right to terminate the license in any country where, after the first commercial sale of the product in the country, there is a continuous two year period in which no product is sold in such country. Nymox is to pay the Rhode Island Hospital a 4% royalty of the net sales price of any product developed and sold under the license. The sponsorship agreement expired in March 2005; however, Nymox retains the exclusive license to patent rights on certain NTP-based technology including a license to two issued U.S. patents. Nymox has screened compounds for their ability to impede the process of premature cell death and thus potentially help slow or halt the loss of brain cells in the Alzheimer’s disease brain. This screening process identified promising drug candidates. The Corporation has developed a candidate, NXD-9062, which has shown significant progress in preclinical studies but successful completion of other pre-clinical studies is necessary before it can move into formal regulatory studies. The Corporation’s third program is based on a new drug candidate for neurodegenerative disease, NXD-5150, which successfully completed important pre-clinical milestones. Nymox has exclusive rights to two patent applications covering NXD-5150 as well as other related drug candidates for neurodegenerative disorders. Nymox faces intense competition for the development of an effective treatment for Alzheimer’s disease. The market conditions for an Alzheimer’s disease drug strongly favor the entry of other corporations into the area. This market is expected to grow rapidly as new drugs enter the market and as the baby boom generation becomes more at risk for developing Alzheimer’s disease. As a result, most of the major pharmaceutical companies and many biotechnology companies have ongoing research and development programs for drugs and treatments for Alzheimer’s disease. Many of these companies have much greater scientific, financial and marketing resources than we have and may succeed in developing and introducing effective treatments for Alzheimer’s disease before we can. At present, four drugs for Alzheimer’s disease are being widely marketed in the United States, Aricept® by Pfizer, Exelon® by Novartis, Razadyne® by Janssen and Namenda® by Forest. These four drugs only treat some of the symptoms of Alzheimer’s disease by enhancing memory and other mental functions and not the underlying causes of the illness. Oncology products We are in the preclinical stage of developing therapeutic products for oncological indications based on technology licensed from the Massachusetts General Hospital. We cannot predict with any certainty whether any such product will successfully complete preclinical testing, whether government regulatory agencies, such as the FDA, will permit such products to proceed to human trials, or whether ultimately any such product will be granted approval for sale and marketing in the U.S., Canada, or elsewhere in the world. New Diagnostic Products Nymox has a number of proprietary diagnostic markers and technologies, including a patented platform for point-of-care testing, and has tests utilizing these technologies in the early stages of development. Nymox also has U.S. patents for a 18


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method and device for using saliva to determine cholesterol levels and for a method of testing for osteoporosis. The Corporation also owns patent rights to several novel biochemical indicators for Alzheimer’s disease. Manufacturing Arrangements Our NicAlertTM and TobacAlertTM products and AlzheimAlertTM kits are currently partly manufactured through out-sourcing arrangements with contract manufacturers. To date, we have not experienced any significant interruptions in the manufacture of these products and the cost of the manufacturing services has not been volatile. The manufacturing services supplied by our current contract manufacturer are not unique or unduly complicated and other contract manufacturers are available to provide similar services in the event that our current contract manufacturer fails to meet our needs. Property and Equipment Nymox and Serex laboratory facilities in Hasbrouck Heights, New Jersey comprise 4,799 square feet of leased space. That lease agreement expires October 31, 2013. Nymox office and research facilities in St. Laurent, Quebec, Canada comprise 11,210 square feet of leased space. The lease agreement expires on August 31, 2014. Nymox Pharmaceutical Corp. and its two US subsidiaries Nymox Corp. and Serex, Inc. own a full complement of equipment used in all aspects of their research and development work. Nymox believes that its facilities are adequate for its current needs and that additional space, if required, would be available on commercially reasonable terms. Governmental Regulation Our AlzheimAlertTM test is subject to extensive government regulation in the United States. Any changes in CMS or state law requirements or in the FDA regulations could have an impact on our future ability to offer or market any reference laboratory services and/or on our ability to obtain reimbursement from the Medicare and Medicaid programs and providers. We have developed a diagnostic kit version of the AlzheimAlertTM test. We will need to obtain FDA approval before we can market or sell such a diagnostic kit version outside of the clinical reference laboratory setting in the United States. Such approval for this type of commercial development is necessary for all in vitro diagnostic kits. On July 15, 2005, an FDA advisory panel voted 5-2 against recommending approval of our PMA application for the kit, citing the need for further studies, such as long term follow-up and autopsy confirmation. We cannot predict with any certainty when or if FDA approval will be forthcoming and we anticipate that more clinical testing or further documentation will be required before approval. If approved, the diagnostic kit would then be subject to postmarketing record and reporting obligations and manufacturing requirements. Similar requirements exist in many other countries. In November 2004, Nymox satisfactorily completed the testing and registration required by European regulatory, environmental and quality standards in order to obtain a CE Mark for the AlzheimAlertTM kit. The CE Mark makes the AlzheimAlertTM kit eligible for sale in the European Union and enables European clinical and hospital laboratories to perform the AlzheimAlertTM test in their own facilities in Europe. The regulatory process leading to such approval can be time-consuming and expensive and can result in an outright denial or a very limited approval only. AlzheimAlertTM will be subject to premarketing and postmarketing requirements applicable to such devices, including those governing: clinical testing;design control procedures;prior FDA approval of a 510(k) application, where the FDA has determined that our diagnostic device is substantially equivalent to a marketed device, or a premarket approval application, where the FDA has been satisfied with clinical studies demonstrating the safety and efficacy of our device;postmarketing record and reporting obligations; andgood manufacturing practices. The requirements for a premarket approval application are analogous to those for the approval of a new drug and include four categories of information: indications for use, device description and manufacturing methods, alternative practices and procedures for the diagnosis of the disease and clinical and nonclinical studies. The requirements for a 510(k) application are generally less onerous but still include indications for use, safety and effectiveness data as well as manufacturing and quality assurance data and information. There can be no assurance that the AlzheimAlertTM test or any other medical device that we may develop in the future will obtain the necessary approvals within a specified time framework, if ever. In addition, the FDA may impose certain postmarketing requirements that may significantly increase the regulatory costs associated with our product. The FDA has recourse to a wide range of administrative sanctions and civil and criminal penalties in order to enforce the applicable laws, rules and regulations. Our therapeutic products under development by Nymox would also have to receive regulatory approval. This is a costly, lengthy and risky process. In the United States, in order for a product to be marketed, it must go through four distinct development and evaluation stages: Product Evaluation We must conduct preliminary studies of potential drug candidates using various screening methods to evaluate them for further testing, development and marketing. 19


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Optimization of Product Formulation The activities in this stage of development involve consultations between us and investigators and scientific personnel. Preliminary selection of screening candidates to become product candidates for further development and further evaluation of drug efficacy is based on a panel of research based biochemical measurements. Extensive formulation work and in vitro testing are conducted for each of various selected screening candidates and/or product candidates. Clinical Screening and Evaluation During this phase of development, portions of which may overlap with product evaluation and optimization of product formulation, initial clinical screening of product candidates is undertaken and full scale clinical trials commence. The FDA must approve any clinical testing on healthy subjects (Phase 1) and on patients (Phase 2 and 3). Final Product Development The activities to be undertaken in final product development include performing final clinical evaluations, conducting large-scale experiments to confirm the reproducibility of clinical responses, making clinical lots for any additional extensive clinical testing that may be required, performing any further safety studies required by the FDA, carrying out process development work to allow pilot scale production of the product, completing production demonstration runs for each potential product, filing new drug applications, product license applications, investigational device exemptions (and any necessary supplements or amendments) and undergoing comprehensive regulatory approval programs and processes. We cannot assure you that we will successfully complete the development and commercialization of any therapeutic products. In the United States, obtaining the necessary FDA approval for any drug is a lengthy, expensive and often arduous process. We cannot predict with any certainty the amount of time the FDA will take to approve one of our drugs or even whether any such approval will be forthcoming. Similar requirements exist in many other countries. In the United States, the FDA approval procedure is a two-step process. We must file an investigational new drug (IND) application for each product with the FDA before beginning the initial (Phase 1) clinical testing of the new drug in healthy subjects. If the FDA has not commented on or questioned the application within 30 days of its filing, initial clinical studies may begin. If, however, the FDA has comments or questions, the questions must be answered to the satisfaction of the FDA before initial clinical testing can begin. In some instances, this process could result in substantial delay and expense. Phase I studies are intended to demonstrate the functional characteristics and safety of a product. After Phase 1 testing, we must conduct extensive clinical trials with patients in order to establish the efficacy and safety of our drug. Once we complete the required clinical testing, we expect to have to file a new drug application for FDA approval in order to market most, if not all, of our new drugs. The application is complicated and detailed and must include the results of extensive clinical and other testing, the cost of which is substantial. The FDA conducts an extensive and often lengthy review of such applications. The agency is required to review applications within 180 days of their filing, but, during the review, frequently requests that additional information be submitted. This starts the 180-day regulatory review period anew when the requested additional information is submitted and, as a result, can significantly extend the review period. Until the FDA actually approves the new drug application, there can be no assurance that the agency will consider the information requested and submitted to justify approval. The packaging and labeling of products are also subject to FDA regulation. Accordingly, it is impossible to anticipate when the FDA will approve a new drug application. Our lead candidate is NX-1207, a treatment for BPH. We cannot predict with any certainty the outcome of future trials, what further steps may be required in order to apply for final FDA approval for this drug or whether the FDA will ultimately grant us such approval. We must also obtain approval for our drugs or diagnostic devices from the comparable regulatory authority in other countries before we can begin marketing our product in that country. The approval procedure varies from country to country and can involve additional testing. The time required may differ from that required for FDA approval. Although there are some procedures for unified filings for certain European countries, in general each country has its own procedures and requirements, many of which are time-consuming and expensive. Thus, there can be substantial delays in obtaining required approvals from both the FDA and foreign regulatory authorities after the relevant applications are filed. After such approvals are obtained, further delays may be encountered before the products become commercially available. If, subsequent to approval, new information becomes available concerning the safety or effectiveness of any approved product, the regulatory authority may require the labeling for the affected product to be revised or the product to be withdrawn. Our manufacturing of any approved drug must conform with the FDA’s good manufacturing practice regulations which govern the production of pharmaceutical products and be subject to inspections and compliance orders. Government regulation also affects our ability to receive an appropriate level of reimbursement for our products. Throughout the developed world, both public and private health care plans are under considerable financial and political pressure to contain their costs. The two principal methods of restricting expenditures on drugs and diagnostic products and services are to deny coverage or, if coverage is granted, to limit reimbursement. For single-payer government health care systems, a decision to deny coverage or to severely restrict reimbursement for one of our products can have an adverse effect on our business and revenues. 20


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In the United States, where, to a significant degree, the patient population for our products is elderly, Medicare and Medicaid are sources of reimbursement. In general, any restriction on reimbursement, coverage or eligibility under either program could adversely affect reimbursement to Nymox for products and services provided to beneficiaries of the Medicare and/or Medicaid programs. Many elderly people are covered by a variety of private health care organizations either operating private health care plans or Medicare or Medicaid programs subject to government regulation. These organizations are also under considerable financial constraints and we may not be able to secure coverage or adequate reimbursement from these organizations. Without coverage, we will have to look to the patients themselves who may be unwilling or unable to pay for the product; in turn, doctors may be reluctant to order or prescribe our products in the absence of coverage of the product for the patient. In March 2010, the United States enacted sweeping health care reform legislation, the Patient Protection and Affordable Care Act. Important market reforms have begun and will continue through full implementation in 2014. The new law is expected to expand access to health care to more than 32 million Americans by the end of the decade. These changes may adversely affect the prices we may charge for any therapeutic drug we develop. The long-term impact of legislative changes in terms of their efficiency, effectiveness and financial viability in delivering health care services to an aging population is uncertain at present. Any legislative or regulatory actions to reduce or contain federal spending under either the Medicare or Medicaid programs could adversely affect our ability to participate in either program as a provider or supplier of services or products and the amount of reimbursement under these programs potentially available to us. Our AlzheimAlertTM test, and any of the new diagnostic and therapeutic products and services that we may develop, will be subject to coverage determinations by health care providers and payers. Federal and state regulations and law and internal coverage policies of health care organizations affect our ability to obtain payments for our products and services. The Medicare program will not pay for any expenses incurred for items or services that are not reasonable and necessary for the diagnosis or treatment of illness or injury or to improve the functioning of a malformed body member. Historically, CMS interpreted this provision in order to exclude from Medicare coverage those medical and health care services that are not demonstrated to be safe and effective by acceptable clinical evidence. CMS recently revised both its national coverage policies and procedures in general and specifically its coverage of diagnostic laboratory tests and constituted a Medicare Coverage Advisory Committee to provide advice on the effectiveness and appropriateness of medical items and services that are eligible for coverage under Medicare. It is unknown how these changes will affect our ability to obtain Medicare coverage for our products and services. However, an adverse national coverage decision with respect to one of our products or services will make it impossible to receive reimbursement from Medicare for that product and more difficult to convince private health care organizations to provide coverage for it. Even if we receive a favorable coverage decision for one of our products or services, there is no guarantee that the level of reimbursement for it will be close to our retail price for it or commensurate with the costs of developing and marketing it. Patents and Proprietary Information We believe that patent and trade secret protection is important to our business, and that our success will depend, in part, on our ability to obtain strong patents, to maintain trade secret protection and to operate without infringing the proprietary rights of others. The commercial success of products incorporating our technologies may depend, in part, upon our ability to obtain strong patent protection. We cannot assure you that additional patents covering new products or improvements will be issued or that any new or existing patents will be of commercial benefit or be valid and enforceable if challenged. We pursue a policy of seeking patent protection for valuable patentable subject matter of our proprietary technology and require all employees, consultants and other persons who may have access to its proprietary technology to sign confidentiality agreements. The Corporation currently owns or has licensed exclusive rights to several hundred patents and patent applications in the U.S. and other countries around the world in support of its proprietary product development programs. Nymox has twenty-three U.S. patents issued or allowed and a corresponding larger number of patents and patent applications worldwide. Nymox has issued patents in the main European markets, including Great Britain, Germany, France, Italy, The Netherlands, Sweden and Spain among others and in other countries such as Japan, Canada and Australia. These patents and patent applications cover much of our current product development and technologies, including new drug candidates, proprietary screening technologies for finding drugs, promising diagnostic markers, new diagnostic assay methods, methods of treating meat and other food products; and anti-infective agents. The earliest expiry date for our current issued patents is October 2013 and the rest range from 2014 through 2028. Nymox's subsidiary, Serex, has eleven patents issued or allowed in the United States and a corresponding larger number of patents and patent applications worldwide. These patents and patent applications cover such areas as Serex's proprietary diagnostic technologies and methodologies. The expiry dates for its patents range from 2013 to 2017. Nymox also has exclusive rights to eleven issued U.S. patents as well as a corresponding larger number of patents and patent applications worldwide through research and license agreements. The earliest of these patents expires in December 2014. Many companies have patents covering various drugs, methods and discoveries in the fields of diagnostics and therapeutics for Alzheimer’s disease and related conditions and of new anti-infective agents. We believe that the patents issued to date will not preclude Nymox from developing and marketing our products; however, it is impossible to predict the extent to which licenses 21


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from third parties will be necessary. If Nymox were to need licenses from third parties there can be no assurance that we could obtain such licenses on commercially reasonable terms, if at all. In the fields of diagnostic methods and diagnostic tests for common human diseases and conditions, where Serex has many of its patents, there are many patents issued covering many areas of diagnostic methods, tests and technologies. We believe that these patents issued to date to other companies will not preclude Serex from developing and marketing its products but you should be aware that it is often difficult to determine the nature, breadth and validity of competing patent claims in these fields, that there has been significant litigation in some of these areas (not involving Serex) and that, if and when Serex’s products become more commercially successful, Serex’s products or patents may become the subject matter of litigation. If Serex were to need licenses from third parties there can be no assurance that it could obtain such license on commercially reasonable terms, if at all. Neither Nymox nor Serex are currently involved in litigation over patent and other intellectual property rights but significant litigation over these matters in the pharmaceutical and biotechnology industry is not uncommon. The validity and extent of patent rights can be very difficult to determine and involve complex legal, factual and scientific questions. Important legal issues about patent protection in the field of biotechnology have not been resolved. Patent litigation is costly and time-consuming and can consume substantial resources. An adverse decision can preclude the marketing of a product, expose us to significant liabilities or require us to obtain third party licenses, which may not be available at commercially reasonable prices. We also rely upon trade secrets, know-how, and continuing technological advancement to develop and maintain our competitive position. We control the disclosure and use of our know-how and confidential information through agreements with the parties involved. In addition, we have confidentiality agreements with our key employees, consultants, officers and directors. There can be no assurance, however, that all confidentiality agreements will be honored, that others will not independently develop equivalent technology, that disputes will not arise as to the ownership of intellectual property, or that disclosure of our trade secrets will not occur. Furthermore, there can be no assurance that others have not obtained or will not obtain patent protection that will exclude us from using our trade secrets and confidential information. To the extent that consultants or research collaborators use intellectual property owned by others in their work with us, disputes may also arise as to the rights to related or resulting know-how or inventions. Competition Rapidly evolving technology and intense competition are the hallmarks of modern pharmaceutical and biotechnology industries. Our competitors include: major pharmaceutical, diagnostic, chemical and biotechnology companies, many of which have financial, technical and marketing resources significantly greater than ours;biotechnology companies, either alone or in collaborations with large, established pharmaceutical companies to support research, development and commercialization of products that may be competitive with ours; andacademic institutions, government agencies and other public and private research organizations which are conducting research into Alzheimer’s disease and which increasingly are patenting, licensing and commercializing their products either on their own or through joint ventures. In the field of Alzheimer’s disease diagnosis, our AlzheimAlertTM test faces growing competition which could detrimentally impact on our ability to successfully market and sell our diagnostic test. Our competitors include: Eli Lilly and Company, which is currently marketing Amyvid® (florbetapir), a radioactive diagnostic agent for Positron Emission Tomography (PET) imaging, which is used to estimate the density of neuritic plaques in patients being evaluated for Alzheimer’s disease.Athena Diagnostics, Inc., a division of Quest Diagnostics, which is currently marketing three tests claimed to aid in the diagnosis of Alzheimer's disease: a genetic test for the rare cases of familial, early-onset Alzheimer's disease; a genetic test for a relatively common mutation of a gene said to increase the likelihood of a person with at least one of the genes contracting the disease; and a test for two proteins in the spinal fluid of patients.Innogenetics NV, which currently markets tests and kits for two proteins and a variant of one of these proteins in the spinal fluid of patients and a genetic test for a relatively common mutation of a gene said to increase the likelihood of a person developing the disease.Amorfix Life Sciences Ltd., which currently markets a research test to detect aggregated amyloid protein in brain test and has under development related blood and CSF tests. There are also a number of other proposed biochemical signs of the disease that could potentially be developed into a commercial diagnostic test as well as various scanning and imaging technologies which compete for a portion of the diagnostic market for Alzheimer’s disease. A number of companies, including GE and Bayer, are actively working to develop imaging technologies for the diagnosis of Alzheimer’s disease. In June 2004, the CMS approved limited coverage of a Positronic Emission Tomography (“PET”) imaging procedure for helping to more precisely distinguish Alzheimer's disease from a rarer type of dementia when clinical evaluation has been inconclusive. In October 2004, the National Institute of Aging in conjunction with other Federal agencies, private companies and organizations launched the Alzheimer’s Disease Neuroimaging Initiative, a $60 million initiative to test whether various scanning and imaging technologies, biochemical markers, and clinical and neuropsychological testing can be combined to help diagnose early Alzheimer’s disease. 22


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Our NicAlertTM and TobacAlertTM products face competition from clinical laboratories such as LabCorp and Quest Diagnostics which provide off-site lab testing for cotinine, the by-product of the body’s breakdown of nicotine measured by NicAlertTM and TobacAlertTM, and from assay suppliers, including immunoassay developers such as OraSure Technologies Inc. and Abraxis LLC, and diagnostic system manufacturers such as Roche Diagnostics, Abbott and Diagnostic Products Corporation. NicAlertTM and TobacAlertTM also face competition from distributors who supply simple yes-no smoking status tests such as NicQuick, and QuickScreen, from NicCheck I, an FDA-cleared smoking status test being marketed by Mossman & Associates Ltd, from SmokeScreen, a chemical color-based tobacco test being marketed by Mermaid Diagnostics, Ltd. in the United Kingdom, and from carbon monoxide (CO) monitors such as SmokeCheck. We also face intense competition for the development of an effective treatment for Alzheimer’s disease. The market conditions for an Alzheimer’s disease drug strongly favor the entry of other corporations into the area. This market is expected to grow rapidly as new drugs enter the market and as the baby boom generation becomes more at risk for developing Alzheimer’s disease. As a result, most of the major pharmaceutical companies and many biotechnology companies have ongoing research and development programs for drugs and treatments for Alzheimer’s disease. Many of these companies have much greater scientific, financial and marketing resources than we have and may succeed in developing and introducing effective treatments for Alzheimer’s disease before we can. At present, four drugs for Alzheimer’s disease are being widely marketed in the United States, Aricept® by Pfizer, Exelon® by Novartis, Razadyne® by Janssen and Namenda® by Forest. These four drugs only treat some of the symptoms of Alzheimer’s disease by enhancing memory and other mental functions and not the underlying causes of the illness. A similar competitive reality prevails in the field of novel anti-infectives. Over the past ten years, there has been an increasing awareness of the medical need and of emerging market opportunities for new treatments for antibiotic resistant bacterial infections. Many of the major pharmaceutical companies are developing anti-infective drugs that either modify their existing drugs or involve new anti-bacterial properties. Many biotechnology companies are developing new classes of anti-bacterial drugs. At least three major pharmaceutical companies have vaccines against bacterial infections in development. To the extent that these companies are able to develop drugs or vaccines that offer treatment for some or all of the indications for our anti-infectives, the market for our products may be adversely affected. Our treatments under development for BPH face significant competition from existing products. There are eight drugs approved for treatment of BPH: five proprietary drugs (tadalafil (Cialis®), dutasteride (Avodart®), tamsulosin (Flomax®), alfusozin (Uroxatral®), and silodosin (Rapaflo®)) a combination of two drugs (dutasteride and tamsulosin) (JalynTM), and four generics (finasteride, terazozin, doxazozin, and prazosin). There are a number of thermal treatments on the market designed to shrink the enlarged prostate by heating its tissue with a device inserted through the urethra (the tube leading from the bladder through the penis through which men urinate) or through the abdomen. The devices on the market use microwave energy (Prostatron®, Targis Therapy® or TherMatrx®), low level radiowaves (TUNA System®), lasers (Indigo LaserOptic Treatment System® or Laserscope GreenLight PVPTM), direct heat or hot water to heat or burn away prostate tissue. A variety of surgical procedures exist to surgically reduce or remove the prostate or to widen the urethra. These include procedures to cut away prostate tissue such as TURP (transurethral resection of the prostate) and using a resectoscope with an electrical loop inserted through the penis to cut the prostate tissue. A small device used to widen the constricted urethra called a prostatic stent can also be inserted. The problem of E. coliO157:H7 contamination of hamburger meat and other food products is also well-known and a number of companies and researchers have been pursuing various potential solutions, including irradiation with x-rays, better detection of contamination, electronic pasteurization, vaccination and competitive exclusion of the pathogenic E. colibacteria by harmless bacteria. The development of alternative solutions to the problem of E. coli infection may adversely affect the market for our treatment for E. coliO157:H7 infection in cattle and contamination of food products. Marketing Our AlzheimAlertTM test is certified with a CE Mark, making the device eligible for sale in the European Union. At present, we do most of our marketing ourselves. To increase our marketing, distribution and sales, we will need to enter into licensing arrangements, contract sales agreements and co-marketing deals. We cannot assure you that we will be able to enter into agreements with other companies on terms acceptable to us, that any licensing arrangement will generate any revenue for the Corporation or that the costs of engaging and retaining the services of a contract sales organization will not exceed the revenues generated. If successfully developed and approved, we plan to market and sell our therapeutic and diagnostic products directly or through co-promotion arrangements or other licensing arrangements with third parties. In cases where we have sole or shared marketing rights, we plan to build a small, focused sales force if and when such products approach marketing approval in some markets, including Europe. Implementation of this strategy will depend on many factors, including the market potential of any products we develop as well as on our financial resources. To the extent we will enter into co-promotion or other licensing arrangements, any revenues received by us will be dependent on the efforts of third parties. Principal Markets The Corporation markets its products for sale principally in the United States, Canada and overseas. Set forth below is a breakdown of the Corporation’s revenues by geographic market for the last three years. The revenue in 2012, 2011 and 2010 23


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include recognition of revenue related to the upfront payment of €10 million (U.S. $13.1 million) received from Recordati in December 2010. Revenues:

   

   Canada

   

   United States

   

   Europe & Other2012

   $

   23,960

   $

   353,397

   $

   2,701,4102011

   $

   11,537

   $

   437,410

   $

   2,664,8682010

   $

   15,900

   $

   505,897

   $

   169,653
 ITEM 4A. UNRESOLVED STAFF COMMENTS None. ITEM 5. OPERATING AND FINANCIAL REVIEW AND PROSPECTS General Nymox Pharmaceutical Corporation is a biopharmaceutical Corporation with three proprietary products on the market, and an R&D pipeline of drug and diagnostic products in development. We have developed the AlzheimAlertTM test as an aid to the diagnosis of Alzheimer’s disease. The kit version of the AlzheimAlertTM test is certified with a CE Mark in Europe. AlzheimAlertTM is an improved version of our AD7CTM test, from which we began generating revenue from sales in 1997. In July 2005, an FDA advisory panel voted 5-2 against approval of our kit, citing the need for further studies, such as long term follow-up and autopsy confirmation. We also market NicAlertTM and TobacAlertTM, our two products which determine a person’s level of exposure to tobacco products. These products are also certified with a CE Mark, making the devices eligible for sale in the European Union. We have under development therapeutic agents for the treatment of Alzheimer’s disease, the treatment of BPH and of certain antibiotic-resistant infections as well as antibacterial agents for E. coli contamination of food and drink products. In September 2006, we announced the successful completion of a multi-center, double-blind, placebo-controlled Phase 2 trial of NX-1207, our lead candidate for the treatment of BPH. In February 2009, the Corporation reported concluding a positive and productive End of Phase 2 (“EOP2”) meeting with the FDA concerning the Phase 3 program for NX-1207. In June 2009, the Corporation began conducting the first of two pivotal double blind placebo controlled Phase 3 trials for NX-1207 that incorporate the specific protocol design recommendations provided to the Corporation by the FDA. In March 2012, Nymox started a Phase 2 U.S. clinical trial to evaluate NX-1207 for the treatment of low grade localized prostate cancer. We also have the rights to a U.S. patent for the use of statin drugs for the treatment or prevention of Alzheimer’s disease. We have incurred operating losses throughout our history. Management believes that such operating losses will continue for at least the next few years. The costs relating to clinical trials for our potential therapeutic products will increase expenditures and delay profitability, despite anticipated increases in sales revenue in the coming years. All figures are presented in U.S. dollars, unless otherwise stated. History of Capital Funding We have funded our operations and projects primarily by selling shares of Nymox’s common stock. However, since 1997, a small portion of our funding also comes from sales. In addition, Nymox received an upfront payment of $13,088,000 through a license and collaboration agreement in 2010. Since its incorporation in May 1995, Nymox raised the capital necessary to fund its on-going research and development work and its marketing and sales operations primarily through private placements of its shares. On December 1, 1997, our common shares began trading on the Nasdaq Stock Market. Nymox’s common shares also traded on the Montreal Exchange from December 18, 1995 to November 19, 1999. On January 27 2003, we entered into a Common Stock Private Purchase Agreement with an investment corporation, Lorros-Greyse, for the future issuance and purchase of Nymox’s common shares. Under the terms of this agreement, which has since been replaced annually by new agreements with Lorros-Greyse, we may give notice to Lorros-Greyse requiring it to purchase a specified dollar amount of our shares. The amount specified in any one notice may be up to $1,000,000 but not less than $100,000. The maximum amount can be higher if both parties agree. The number of shares Nymox will issue to Lorros-Greyse in return for that money will be equal to the amount specified in the notice divided by 97% of the average market price of our common shares for the five trading days preceding the giving of the notice. The Corporation must comply with general covenants in order to draw on its facility, including maintaining its stock exchange listing and registration requirements and having no material adverse effects, as defined in the agreement, with respect to the business and operations of the Corporation. The Corporation may terminate the agreement before the 24-month term, if it has issued at least $8 million of common shares under the agreement. 24


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Under the agreement dated November 1, 2010; we received a total of $3,200,000 during 2011. On November 1, 2011, we signed a new Common Stock Private Purchase Agreement, whereby Lorros-Greyse is committed to purchase up to $15 million of Nymox’s common shares over the twenty-four month period beginning in November 2011, subject to the same terms and conditions as before. Under this agreement dated November 1, 2011, which became effective December 19, 2011, we received a total of $3,575,000 for the following shares under this common stock private purchase agreement: May 23, 2012, 132,100 common shares were issued at a price of $7.57 per share.August 2, 2012, 88,087 common shares were issued at a price of $5.96 per share.September 20, 2012, 95,652 common shares were issued at a price of $5.75 per share.October 30, 2012, 82,781 common shares were issued at a price of $6.04 per share.November 28, 2012, 160,000 common shares were issued at a price of $6.25 per share. On November 1, 2012, we signed a new Common Stock Private Purchase Agreement, which became effective December 19, 2012, whereby Lorros-Greyse is committed to purchase up to $15 million of Nymox’s common shares over the twenty-four month period beginning in November 2012, subject to the same terms and conditions as before. As at March 15, 2013, one drawing was made under the new common stock private purchase agreement, for total proceeds of $1,000,000. On February 4, 2013, 153,610 common shares were issued at a price of $6.51 per share. As of March 15, 2013, Nymox had approximately $14 million of financing available under the facility. We expect this Common Stock Private Purchase Agreement to provide sufficient financing to enable us to advance our research and product development for the next two years. Also, the Corporation has received total proceeds of approximately $1.09 million from the exercise of 382,400 options since 1995. In 2011, 28,000 options were exercised. In 2012, 8,000 options were exercised (2011 – 28,000; 2010 – 0). An additional 75,999 shares have also been issued relating to options under “cashless exercises”. Pursuant to the share purchase agreement we entered into in March 2000 to acquire a controlling interest of Serex, Inc., a total of 257,607 additional shares and 158,526 warrants were issued in exchange for the shares of Serex. Since January 2004, 137,723 of these warrants have been exercised under a “cashless exercise”, whereby the warrant holder receives a number of shares equivalent in value to the net difference between the strike price on the warrant and the average market price on the day before the date of the “cashless exercise”, according to a formula contained in the warrant agreement. The net effect of these “cashless exercises” has been the issuance of 21,351 shares of Nymox common stock. Another 1,090 of these warrants were exercised resulting in the issuance of 1,090 shares of Nymox, for proceeds of $4,033. The remaining 19,713 warrants expired on July 31, 2005. In total, Nymox has raised over $70.5 million through the issuance of common stock or securities exercisable for shares of common stock, since its incorporation in May 1995. We have no contractual obligations of significance other than long-term lease commitments for our premises in Canada and the United States of $32,010 per month through to August 2014 and October 2013 respectively. Contractual obligations are summarized in the Management’s Discussion and Analysis below. 25


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MANAGEMENT'S DISCUSSION AND ANALYSIS (in US dollars) This Management’s discussion and analysis (“MD&A”) comments on the Corporation’s operations, performance and financial condition as at and for the years ended December 31, 2012, 2011 and 2010. This MD&A should be read together with the audited Consolidated Financial Statements and the related notes. This MD&A is dated March 15, 2013. All amounts in this report are in U.S. dollars, unless otherwise noted. Except as otherwise indicated, all financial information contained in this MD&A and in the Consolidated Financial Statements has been prepared in accordance with International Financial Reporting Standards (“IFRS”) as issued by the International Accounting Standards Board (“IASB”). The Consolidated Financial Statements and this MD&A were reviewed by the Corporation’s Audit and Finance Committee and were approved by our Board of Directors. Additional information about the Corporation can be obtained on EDGAR at www.sec.gov or on SEDAR at www.sedar.com. Overview Corporate Profile Nymox Pharmaceutical Corporation is a biopharmaceutical company with a significant R&D pipeline in development. Nymox is developing NX-1207, a novel treatment for benign prostatic hyperplasia which is in Phase 3 trials in the U.S. In December 2010, the Corporation signed a license and collaboration agreement with Recordati, a European pharmaceutical group, for the development and commercialization of NX-1207 in Europe including Russia and the CIS, the Middle East, the Maghreb area of North Africa and South Africa. The license and collaboration agreement covers the use of NX-1207 for the treatment of BPH as the initial indication for development and commercialization. NX-1207 showed positive results for the treatment of BPH in Phase 1 and 2 clinical trials in the U.S. and in follow-up studies of available subjects from the completed clinical trials. In June 2009, the Corporation began conducting the first of two pivotal double blind placebo controlled Phase 3 trials for NX-1207 that incorporate the specific protocol design recommendations provided to the Corporation by the FDA. The two pivotal Phase 3 studies for NX-1207 are being conducted at well-known investigational sites across the U.S. with planned enrollment of 1,000 patients. The first Phase 3 study, NX02-0017, completed enrollment in November 2012. An open-label U.S. re-injection safety study of NX-1207 for BPH was started in July of 2011 and reached completion of its primary endpoint assessment in January 2013. A Phase 2 study of NX-1207 for low grade localized prostate cancer was started in March 2012. The Corporation is also developing new treatments for bacterial infections in humans. Nymox has candidates which are under development as drug treatments aimed at the causes of Alzheimer’s disease, and has several other drug candidates in development. Nymox has U.S. and global patent rights for the use of statin drugs for the treatment and prevention of Alzheimer’s disease. Nymox developed the AlzheimAlertTM test, which is certified with a CE Mark in Europe. Nymox developed and markets NicAlertTM and TobacAlertTM; which are tests that use urine or saliva to detect use of and exposure to tobacco products. NicAlertTM has received clearance from the FDA and is also certified with a CE Mark in Europe. TobacAlertTM is the first test of its kind to accurately measure second and third hand smoke exposure in individuals. We have incurred operating losses throughout our history. Management believes that such operating losses will continue for at least the next few years. The costs relating to clinical trials for our potential therapeutic products will increase expenditures and delay profitability, despite anticipated increases in sales revenue in the coming years. Risk Factors The business activities of the Corporation since inception have been devoted principally to research and development. Accordingly, the Corporation has had limited revenues from sales and has not been profitable to date. We refer to the Risk Factors section of our Form 20-F filed on EDGAR and on SEDAR for a discussion of the management and investment issues that affect the Corporation and our industry. The risk factors that could have an impact on the Corporation’s financial results are summarized as follows: Our Clinical Trials for Our Therapeutic Products in Development, Such as NX-1207, May Not be Successful and We May Not Receive the Required Regulatory Approvals Necessary to Commercialize These ProductsOur Clinical Trials for Our Therapeutic Products, Such as NX-1207, May Be Delayed, Making it Impossible to Achieve Anticipated Development or Commercialization TimelinesA Setback in Any of Our Clinical Trials Would Likely Cause a Drop in the Price of our SharesWe May Not be Able to Make Adequate Arrangements with Third Parties for the Commercialization of our Product Candidates, such as NX-1207We May Not Achieve our Projected Development Goals in the Time Frames We Announce and ExpectEven If We Obtain Regulatory Approvals for Our Product Candidates, We Will be Subject to Stringent Ongoing Government RegulationIt is Uncertain When, if Ever, We Will Make a ProfitWe May Not Be Able to Raise Enough Capital to Develop and Market Our ProductsWe Face Challenges in Developing, Manufacturing and Improving Our ProductsOur Products and Services May Not Receive Necessary Regulatory ApprovalsWe Face Significant and Growing Competition 26


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We May Not Be Able to Successfully Market Our ProductsProtecting Our Patents and Proprietary Information is Costly and DifficultWe Face Changing Market ConditionsHealth Care Plans May Not Cover or Adequately Pay for Our Products and ServicesWe Are Subject to Continuing Potential Product Liability Risks, Which Could Cost Us Material Amounts of MoneyThe Issuance of New Shares May Dilute Nymox’s StockWe Face Potential Losses Due to Foreign Currency Exchange RisksWe Have Never Paid a Dividend and are Unlikely to do so in the Foreseeable Future Critical Accounting Policies The consolidated financial statements of the Corporation have been prepared under International Financial Reporting Standards as issued by the International Accounting Standards Board. The Corporation’s functional and presentation currency is the United States dollar. Our accounting policies are described in the notes to our annual audited consolidated financial statements. We consider the following policies to be the most critical in understanding the judgments that are involved in preparing our financial statements and the matters that could impact our results of operations, financial condition and cash flows. Revenue Recognition The Corporation has generally derived its revenue from product sales and collaboration agreements. Revenue from product sales is recognized when the product has been delivered and obligations as defined in the agreement are performed. Collaboration agreements that include multiple deliverables are considered to be multiple-element arrangements. Under this type of arrangement, the identification of separate units of accounting is required and revenue is allocated among the separate units based on their relative fair values. Payments received under a collaboration agreement may include upfront payments, milestone payments, sale of goods, royalties and license fees. Revenue for each unit of accounting are recorded as described below: (i)
    Upfront payments:Upfront payments are deferred and recognized as revenue on a systematic basis over the estimated service period. Changes in estimates are recognized prospectively when changes to the expected term are determined.(ii)
    Milestone payments:Revenue subject to the achievement of milestones is recognized only when the specified events have occurred and collectability is reasonably assured.Specifically, the criteria for recognizing milestone payments are that (i) the milestone is substantive in nature, (ii) the achievement was not reasonably assured at the inception of the agreement, and (iii) the Corporation has no further involvement or obligation to perform associated with the achievement of the milestone, as defined in the related collaboration arrangement.(iii)
    Sale of goods:Revenue from the sale of goods is recognized when the Corporation has transferred to the buyer the significant risks and rewards of ownership of the goods, there is no continuing management involvement with the goods, and the amount of revenue can be measured reliably.(iv)
    Royalties and license fees:Royalties and license fees are recognized when conditions and events under the license agreement have occurred and collectability is reasonably assured. Revenue recognition is subject to critical judgments, particularly in the collaboration agreement described above. Management uses judgment in estimating the service period over which revenue is recognized. Valuation of Property and Equipment Property and equipment are stated at cost and are amortized on a straight-line basis over the estimated useful lives. The Corporation reviews the unamortized balance of property and equipment, and recognizes any impairment in carrying value when it is identified. Factors we consider important, which could trigger an impairment review include: Significant changes in the manner of our use of the acquired assets or the strategy for our overall business; andSignificant negative industry or economic trends. The recoverable amount of an asset or cash-generating unit is the greater of its value in use and its fair value less costs to sell. In assessing value in use, the estimated future cash flows are discounted to their present value using a pre-tax discount rate that reflects current market assessments of the time value of money and the risks specific to the asset. For the purpose of impairment testing, assets that cannot be tested individually are grouped together into the smallest group of assets that 27


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generates cash inflows from continuing use that are largely independent of the cash inflows of other assets or groups of assets (the “cash-generating unit, or CGU”). An impairment loss is recognized if the carrying amount of an asset or its CGU exceeds its estimated recoverable amount. Impairment losses recognized in respect of CGUs are allocated to reduce the carrying amounts of the assets in the CGU on a pro rata basis. Future events could cause management to conclude that impairment indicators exist and that the carrying values of the Corporation’s property and equipment are impaired. Stock-based Compensation Stock-based compensation is recorded using the fair value based method for stock options issued to employees and non-employees. Under this method, compensation cost related to employee awards is measured at fair value at the date of grant, net of forfeitures, and is expensed over the award’s vesting period. The Corporation uses the Black-Scholes options pricing model to calculate stock option values, which requires certain assumptions, including the future stock price volatility and expected time to exercise. There is estimation uncertainty with respect to selecting inputs to the Black-Scholes pricing model used to determine the fair value of the stock options. Changes to any of these assumptions, or the use of a different option pricing model, could produce different fair values for stock-based compensation, which could have a material impact on the Corporation’s earnings. Recoverability of Deferred Tax Assets Management judgment is required in assessing the recoverability of deferred tax assets. We have recorded no deferred tax assets as of December 31, 2012 and 2011, due to uncertainties related to our ability to utilize all, or a portion of, our deferred tax assets, primarily consisting of net operating losses carried forward and other unclaimed deductions, before they expire. In assessing the recoverability of deferred tax assets, management considers whether it is probable that some portion or all of the deferred tax assets will not be recovered. The ultimate recoverability of deferred tax assets is dependent upon the generation of future taxable income and tax planning strategies. The generation of future taxable income is dependent on the successful commercialization of the Corporation’s products and technologies. Results of Operations Selected Annual Information

   

   

   

   

   2012

   

   

   2011

   

   

   2010Total revenues

   

   

   

   

   $3,072,587

   

   

   $3,113,815

   

   

   $691,450Net loss

   

   

   

   

   $(7,627,589

   )

   

   $(9,652,389

   )

   

   $(6,536,313

   )Loss per share (basic & diluted)

   

   

   

   

   $(0.23

   )

   

   $(0.30

   )

   

   $(0.20

   )Total assets

   

   

   

   

   $1,754,179

   

   

   $6,375,266

   

   

   $13,502,222Non-current financial liabilities

   

   

   

   

   $400,000

   

   

   $400,000

   

   

   $400,000Quarterly Results

   

   Q4 – 2012

   

   

   Q3 – 2012

   

   

   Q2 – 2012

   

   

   Q1 – 2012Total revenues

   

   $789,550

   

   

   $764,564

   

   

   $778,894

   

   

   $739,579Net loss

   

   $(2,813,922

   )

   

   $(1,245,563

   )

   

   $(1,721,128

   )

   

   $(1,846,974

   )Loss per share (basic & diluted)

   

   $(0.08

   )

   

   $(0.04

   )

   

   $(0.05

   )

   

   $(0.06

   )Q4 – 2011

   

   

   Q3 – 2011

   

   

   Q2 – 2011

   

   

   Q1 – 2011Total revenues

   

   $777,606

   

   

   $804,712

   

   

   $766,482

   

   

   $765,015Net loss

   

   $(1,659,125

   )

   

   $(1,614,041

   )

   

   $(1,948,132

   )

   

   $(4,431,091

   )Loss per share (basic & diluted)

   

   $(0.05

   )

   

   $(0.05

   )

   

   $(0.06

   )

   

   $(0.14

   )
 The revenues in 2012 and 2011 include the recognition of revenue related to the upfront payment of €10 million (US$13.1 million) received from Recordati in December 2010. Results of Operations – 2012 compared to 2011 Net losses were $2,813,922, or $0.08 per share, for the quarter, and $7,627,589, or $0.23 per share, for the year ended December 31, 2012, compared to $1,659,125, or $0.05 per share, for the quarter and $9,652,389, or $0.30 per share, for the year ended December 31, 2011. Net losses include stock compensation charges of $1,962,085 in 2012 and $4,005,404 in 2011. The decrease in net losses is principally attributable to the lower stock compensation charges recorded in 2012 compared to the same period in 2011. The weighted average number of common shares outstanding for the year ended December 31, 2012 was 33,176,185 compared to 32,711,431 for the same period in 2011. Revenues Revenues from sales of goods amounted to $135,150 for the quarter and $454,987 for the year ended December 31, 2012, compared with $123,206 for the quarter and $496,215 for the year ended December 31, 2011. A reduction in orders by one client for NicAlertTM/TobacAlertTM explains the decrease in sales for 2012 compared to 2011. The development of therapeutic candidates and of moving therapeutic product candidates through clinical trials is a priority for the Corporation at this time. The growth of sales will become more of a priority once these candidates have reached the marketing stage. The Corporation expects that revenues will increase if and when product candidates pass clinical trials and are launched on the market. 28


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For the three months and year ended December 31, 2012, amounts of $654,400 and $2,617,600 respectively were recognized as revenue relating to the upfront payment received from Recordati in December 2010, compared to $654,400 and $2,617,600 respectively for the three months and year ended December 31, 2011. At December 31, 2012, the deferred revenue related to this transaction recorded in the statement of financial position amounted to $7,743,733. Research and Development Research and development expenditures were $3,218,858 for the quarter and $8,572,528 for the year ended December 31, 2012, compared with $1,890,452 for the quarter and $9,461,081 for the year ended December 31, 2011. Research and development expenditures include costs incurred in advancing Nymox’s BPH product candidate NX-1207 through clinical trials, as well as costs related to its R&D pipeline in development. Research and development expenditures also include stock compensation charges of $1,653,428 for the quarter and $1,686,310 for the year ended December 31, 2012 and $32,042 for the quarter and $2,357,307 for the year ended December 31, 2011. Expenditures on the clinical trials for NX-1207 increased for the quarter compared to the same period in 2011 because of the initiation of new trials. The decrease in expenses for the year ended 2012 is primarily attributable to lower stock compensation charges compared to 2011. The balance of the decrease for the year is due to reductions in expenditures in 2012 relating to the initiation of new sites to the trials compared to the corresponding period in 2011. In 2012, research tax credits and grants amounted to $289,766 compared to $486,910 in 2011. The decrease is due to the recognition in 2011 of the grant awarded from the U.S. government under the Qualifying Therapeutic Discovery Project in the amount of $244,479, which was not repeated in 2012. The Corporation expects that research and development expenditures will decrease as product candidates finish development and clinical trials. However, because of the early stage of development of the Corporation’s R&D projects, it is impossible to outline the nature, timing or estimated costs of the efforts necessary to complete these projects, nor the anticipated completion dates for these projects. The facts and circumstances indicating the uncertainties that preclude us from making a reasonable estimate of the costs and timing necessary to complete projects include the risks inherent in any field trials, the uncertainty as to the nature and extent of regulatory requirements both for safety and efficacy, and the ability to manufacture the products in accordance with current good manufacturing requirements (cGMP) and in sufficient quantities both for large scale trials and for commercial use. A drug candidate that shows efficacy can take a long period (7 years or more) to achieve regulatory approval. There is also uncertainty whether we will be able to successfully adapt our patented technologies or whether any new products we develop will pass proof-of-principle testing both in the laboratory and in clinical trials, and whether we will be able to manufacture such products at a commercially competitive price. In addition, given the very high costs of development of therapeutic products, we anticipate having to partner with larger pharmaceutical companies to bring therapeutic products to market. The terms of such partnership arrangements along with our related financial obligations cannot be determined at this time and the timing of completion of the approval of such products will likely not be within our sole control. Marketing Expenses Marketing expenditures were $36,756 for the quarter and $158,431 for the year ended December 31, 2012, in comparison to expenditures of $51,964 for the quarter and $642,235 for the year ended December 31, 2011. Marketing expenditures also include stock compensation charges of $389 for the year ended December 31, 2012 and $434,635 in 2011. The decrease in expenses for the quarter and the year is primarily attributable to lower stock compensation charges in 2012 compared to 2011. The balance of the decrease for the year is due to a decrease in promotional expenses by approximately $51,000 in 2012 compared to 2011. The Corporation expects that marketing expenditures will increase if and when new products are launched on the market. General and Administrative Expenses General and administrative expenses were $356,341 for the quarter and $1,972,120 for the year ended December 31, 2012, compared with $443,895 for the quarter and $2,832,870 for the year ended December 31, 2011. General and administrative expenditures also include stock compensation charges of $275,386 for the year ended December 31, 2012 and $1,213,462 in 2011. The decrease in expenses for the quarter and the year is attributable to lower stock compensation charges in 2012 compared to 2011. The Corporation expects that general and administrative expenditures will increase as new product development leads to expanded operations. Finance Costs - Foreign Exchange The Corporation incurs expenses in the local currency of the countries in which it operates, which include the United States and Canada. Approximately 57% of 2012 expenses (2011 – 66%; 2010 – 78%) were in U.S. dollars. Foreign exchange fluctuations had no meaningful impact on the Corporation’s results in 2012, 2011 or 2010. Inflation The Corporation does not believe that inflation has had a significant impact on its results of operations. Results of Operations – 2011 compared to 2010 Net losses were $1,659,125, or $0.05 per share, for the quarter, and $9,652,389, or $0.30 per share, for the year ended December 31, 2011, compared to $2,057,314, or $0.06 per share, for the quarter and $6,536,313, or $0.20 per share, for the year ended December 31, 2010. Net losses include stock compensation charges of $4,005,404 in 2011 and $478,865 in 2010. 29


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The increase in net losses in 2011 is principally attributable to the stock compensation charges. The weighted average number of common shares outstanding for the year ended December 31, 2011 was 32,711,431 compared to 31,940,584 for the same period in 2010. Revenues Revenues from sales of goods amounted to $123,206 for the quarter and $496,215 for the year ended December 31, 2011, compared with $204,076 for the quarter and $582,383 for the year ended December 31, 2010. A large number of orders by one client for NicAlertTM/TobacAlertTM in 2010 were not repeated in 2011, which explains the decrease in sales. For the three months and year ended December 31, 2011, amounts of $654,400 and $2,617,600 respectively were recognized as revenue relating to the upfront payment received from Recordati in December 2010, compared to $109,067 for the three months and year ended December 31, 2010. At December 31, 2011, the deferred revenue related to this transaction recorded in the statement of financial position amounted to $10,361,333. Research and Development Research and development expenditures were $1,890,452 for the quarter and $9,461,081 for the year ended December 31, 2011, compared with $1,396,699 for the quarter and $5,116,227 for the year ended December 31, 2010. Research and development expenditures include costs incurred in advancing Nymox’s BPH product candidate NX-1207 through clinical trials, as well as costs related to its R&D pipeline in development. Research and development expenditures also include stock compensation charges of $2,357,307 in the year ended December 31, 2011 and $318,184 in the comparative period in 2010. The increase in expenses in 2011 is primarily attributable to the stock compensation charges due to 905,000 options mainly granted in the first quarter of 2011 of which the majority vested immediately. Expenditures on the clinical trial for NX-1207 also increased compared to the same period in 2010, principally on salaries by approximately $353,000 and on clinical site and laboratory services by approximately $1,501,000, with corresponding increases for the quarter. In 2011, research tax credits and grants amounted to $486,910 compared to $236,101 in 2010 due to the recognition in 2011 of the grant awarded from the U.S. government under the Qualifying Therapeutic Discovery Project in the amount of $244,479. Marketing Expenses Marketing expenditures were $51,964 for the quarter and $642,235 for the year ended December 31, 2011, in comparison to expenditures of $42,589 for the quarter and $152,389 for the year ended December 31, 2010. Marketing expenditures also include stock compensation charges of $434,635 for the year ended December 31, 2011 and $4,780 in 2010. The increase in expenses in 2011 is primarily attributable to the stock compensation charges. The balance of the increase for the quarter and for the year is due to an increase in salaries by approximately $20,000 and costs of publicity by approximately $35,000 in 2011 compared to 2010. General and Administrative Expenses General and administrative expenses were $443,895 for the quarter and $2,832,870 for the year ended December 31, 2011, compared with $923,464 for the quarter and $1,847,122 for the year ended December 31, 2010. General and administrative expenditures also include stock compensation charges of $1,213,462 for the year ended December 31, 2011 and $155,901 in 2010. The increase in expenses in 2011 is attributable to the stock compensation charges. The decrease for the quarter is due to higher expenditures in the fourth quarter of 2010 in professional fees by approximately $780,000, which were not repeated in 2011. Contractual Obligations Nymox has no contractual obligations of significance other than long-term lease commitments for rental of laboratory and office space, insurance premium installments, other operating leases and redeemable preferred shares as follows: Contractual Obligations

   

   Total

   

   

   Less than 1 year

   

   

   1-3 years

   

   

   4+ yearsRent for laboratory and office space

   

   $541,352

   

   

   $355,837

   

   

   $185,515

   

   

   $0Insurance Premium Installments

   

   $68,141

   

   

   $68,141Operating Leases

   

   $25,508

   

   

   $10,595

   

   

   $12,009

   

   

   $2,904Total Contractual Obligations

   

   $635,001

   

   

   $434,573

   

   

   $197,524

   

   

   $2,904
 The redeemable preferred shares for the Corporation’s subsidiary Serex, Inc. in the amount of $400,000 have no specific terms of repayment. Off-Balance Sheet Arrangements The Corporation has no binding commitments for the purchase of property, equipment or intellectual property. The Corporation has no commitments that are not reflected in the statement of financial position except for operating leases and insurance premium installments. 30


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Transactions with Related Parties The Corporation had no transactions with related parties in 2012 and 2011. Refer to note 18 of the consolidated financial statements for key management personnel disclosures. Financial Position Liquidity and Capital Resources As of December 31, 2012, cash and receivables including tax credits totalled $1,030,075 and $617,099 respectively compared with $5,918,921 and $393,169 in the comparative period in 2011. In December 2010, the Corporation received an upfront payment of €10 million (US$13.1 million) pursuant to a license and collaboration agreement with Recordati for the development and commercialization of NX-1207 in Europe and other countries. The decrease in cash is primarily due to the use of this upfront payment. The increase in receivables is primarily due to timing of collection of research tax credits. In November 2011, the Corporation signed a common stock private purchase agreement, whereby Lorros-Greyse Investments, Ltd. (the “Purchaser”) was committed to purchase up to $15 million of the Corporation’s common shares over a twenty-four month period. The agreement became effective December 19, 2011. As at December 31, 2012, five drawings were made under this purchase agreement, for total proceeds of $3,575,000. On May 23, 2012, 132,100 common shares were issued at a price of $7.57 per share. On August 2, 2012, 88,087 common shares were issued at a price of $5.96 per share. On September 20, 2012, 95,652 common shares were issued at a price of $5.75 per share. On October 30, 2012, 82,781 common shares were issued at a price of $6.04 per share. On November 28, 2012, 160,000 common shares were issued at a price of $6.25 per share. The Corporation negotiated a new agreement with the Purchaser on November 1, 2012, which became effective December 19, 2012, under the same terms and conditions of the previous agreement. The Corporation intends to access financing under this agreement when appropriate to fund its research and development. As at March 15, 2013, the Corporation had $14 million of financing available under the facility over the remaining 20 months under the agreement. The Corporation believes that cash balances, funds from operations, as well as funds from the common stock private purchase agreement will be sufficient to meet the Corporation’s cash requirements for the next twelve months. The Corporation must comply with general covenants in order to draw on its facility including maintaining its stock exchange listing and registration requirements and having no material adverse effects, as defined in the agreement, with respect to the business and operations of the Corporation. The Corporation relies primarily on this financing, and when applicable, collaboration agreements to fund its operations. In order to achieve the Corporation’s business plan and realization of its assets and liabilities in the normal course of operations, the Corporation anticipates the need to raise additional capital and/or achieve sales and other revenue generating activities. Capital disclosures The Corporation's objective in managing capital is to ensure a sufficient liquidity position to finance its research and development activities, general and administrative expenses, working capital and overall capital expenditures, including those associated with patents. The Corporation makes every attempt to manage its liquidity to minimize shareholder dilution when possible. The Corporation defines capital as total equity. To fund its activities, the Corporation has followed an approach that relies almost exclusively on the issuance of common shares and, during 2010, entered into a collaboration agreement. Since inception, the Corporation has financed its liquidity needs primarily through private placements and, since 2003, through a financing agreement with an investment company that has been replaced annually by a new agreement with the same purchaser (see note 9 (a) - Common Stock Private Purchase Agreement). The Corporation intends to access financing under this agreement when appropriate to fund its research and development activities. The financial crisis in the United States and the global economic environment has had a negative impact on the availability of liquidity in the market. Since 2003 through to December 2012, the Purchaser has always complied with the drawdowns made pursuant to the agreement. The Corporation believes that cash balances, funds from operations, as well as funds from the Common Stock Private Purchase Agreement will be sufficient to meet the Corporation’s cash requirements for the next twelve months. The Corporation must comply with general covenants in order to draw on its facility including maintaining its stock exchange listing and registration requirements and having no material adverse effects, as defined in the agreement, with respect to the business and operations of the Corporation. The capital management objectives remain the same as for the previous fiscal year. When possible, the Corporation tries to optimize its liquidity needs by non-dilutive sources, including sales, collaboration agreements, research tax credits and interest income. The Corporation's general policy on dividends is to retain cash to keep funds available to finance its research and development and operating expenses. The Corporation has no debt. The Corporation is not subject to any capital requirements imposed by external parties. 31


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Financial risk management This section provides disclosures relating to the nature and extent of the Corporation’s exposure to risks arising from financial instruments, including foreign currency risk, credit risk, interest rate risk and liquidity risk, and to how the Corporation manages those risks. Foreign currency risk The Corporation uses the US dollar as its measurement currency because a substantial portion of revenues, expenses, assets and liabilities of its Canadian and US operations are denominated in US dollars. The Corporation’s equity financing facility is also in US dollars. Foreign currency risk is limited to the portion of the Corporation’s business transactions denominated in currencies other than the US dollar. The Canadian operation has transactions denominated in Canadian dollars, principally relating to salaries and rent. Additional variability arises from the translation of monetary assets and liabilities denominated in currencies other than the US dollar at each statement of financial position date. Fluctuations in the currency used for the payment of the Corporation’s expenses denominated in currencies other than the US dollar (primarily Canadian dollars) could cause unanticipated fluctuations in the Corporation’s operating results, but would not impair or enhance its ability to pay its Canadian dollar denominated obligations. The Corporation’s objective in managing its foreign currency risk is to minimize its net exposures to foreign currency cash flows by transacting with parties in US dollars to the maximum extent possible. The Corporation does not engage in the use of derivative financial instruments to manage its currency exposures. Approximately 57% of expenses that occurred during the year ended December 31, 2012 (2011 - 66%; 2010 – 78%) were denominated in US dollars. Foreign exchange fluctuations had no meaningful impact on the Corporation’s results in 2012, 2011 or 2010. The following table provides significant items exposed to foreign exchange: CA$

   

   December 31, 2012

   

   

   December 31, 2011Cash

   

   $167,006

   

   

   $320,662Trade accounts receivable, other receivables and research tax credits receivable

   

   $54,169

   

   

   $119,192Trade accounts payable and accrued liabilities

   

   $(389,256

   )

   

   $(399,802

   )$(168,081

   )

   

   $40,052
 The following exchange rates were applied for the years ended December 31, 2012, 2011 and 2010: **Average rate (twelve months)**

   **Reporting date rate**US$ - CA$ - December 31, 2012

   0.9996

   0.9949US$ - CA$ - December 31, 2011

   0.9891

   1.0170US$ - CA$ - December 31, 2010

   1.0299

   0.9946
 Based on the Corporation’s foreign currency exposures noted above, varying the above foreign exchange rates to reflect a 5% strengthening of the US dollar would have increased the net loss for the year ended December 31, 2012 by less than $5,000, assuming that all other variables remained constant. An assumed 5% weakening of the US dollar would have had an equal but opposite effect on the amount shown above, on the basis that all other variables remained constant. Credit risk Credit risk results from the possibility that a loss may occur from the failure of another party to perform according to the terms of the contract. Financial instruments that potentially subject the Corporation to concentrations of credit risk consist primarily of cash and trade accounts receivable. Cash is maintained with high-credit quality financial institutions. For trade accounts receivable, the Corporation performs periodic credit evaluations and typically does not require collateral. Allowances are maintained for potential credit losses consistent with the credit risk, historical trends, general economic conditions and other information. The Corporation has a limited number of customers. Included in the consolidated statement of financial position are trade accounts receivable of $30,732 (December 31, 2011 - $31,546), all of which were aged under 45 days. Three customers (December 31, 2011 - four customers) accounted for 86.4% (December 31, 2011 - 100%) of the trade receivables balance at December 31, 2012, all of whom have a good payment record with the Corporation. No bad debt expense was recorded for the year ended December 31, 2012, nor for the year ended December 31, 2011. At December 31, 2012, the Corporation’s maximum credit exposure corresponded to the carrying amount of cash, trade accounts receivable and other receivables. 32


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Interest rate risk Interest rate risk is the risk that the fair value or future cash flows of a financial instrument will fluctuate because of changes in market interest rates. Cash bears interest at a variable rate. Trade accounts receivable, other receivables, trade accounts payable and accrued liabilities bear no interest. The Corporation has no other interest-bearing financial instruments. Based on the value of variable interest-bearing cash during the year ended December 31, 2012, an assumed 0.5% increase or 0.5% decrease in interest rates during such period would have had no significant effect on the net loss. Liquidity risk Liquidity risk is the risk that the Corporation will not be able to meet its financial obligations as they fall due. The Corporation manages liquidity risk through the management of its capital structure, as outlined in note 14 - Capital disclosures. The Corporation does not have an operating credit facility and finances its activities through an equity financing agreement with an investment company, as described in note 9 (a) - Common Stock Private Purchase Agreement. The following are the contractual maturities of financial liabilities: Trade accounts payable and accrued liabilities:

   

   Carrying Amount

   

   

   Less than 1 year

   

   

   1 year to 5 yearsDecember 31, 2012

   

   $1,055,159

   

   

   $1,055,159

   

   

   –December 31, 2011

   

   $811,492

   

   

   $811,492

   

   

   –
 The redeemable preferred shares for the Corporation’s subsidiary Serex, Inc. in the amount of $400,000 have no specific terms of repayment. Outstanding Share Data As at March 15, 2013, there were 33,731,492 common shares of Nymox issued and outstanding. In addition, 5,930,500 share options are outstanding, of which 5,890,500 are currently vested. There are no warrants outstanding. Subsequent Event As at March 15, 2013, one drawing was made under the new common stock private purchase agreement, for total proceeds of $1,000,000. On February 4, 2013, 153,610 common shares were issued at a price of $6.51 per share. Disclosure Controls and Procedures Disclosure controls and procedures are designed to provide reasonable assurance that information required to be disclosed is accumulated and communicated to senior management on a timely basis so that appropriate decisions can be made regarding public disclosure. The Corporation’s Chief Executive Officer and its Chief Financial Officer are responsible for establishing and maintaining disclosure controls and procedures. They are assisted in this responsibility by the Corporation’s disclosure committee, which is composed of members of senior management. Based on an evaluation of the Corporation’s disclosure controls and procedures, the Chief Executive Officer and Chief Financial Officer have concluded that the disclosure controls and procedures were effective as of December 31, 2012. Internal Control over Financial Reporting Management’s Annual Report on Internal Control Over Financial Reporting Our management is responsible for establishing and maintaining adequate internal control over financial reporting. Our internal control over financial reporting includes those policies and procedures that: (1) pertain to the maintenance of records that, in reasonable detail, accurately and fairly reflect the transactions and dispositions of our assets; (2) provide reasonable assurance that transactions are recorded as necessary to permit preparation of financial statements in accordance with generally accepted accounting principles, and that our receipts and expenditures are being made only in accordance with authorizations of our management and directors; and (3) provide reasonable assurance regarding prevention or timely detection of unauthorized acquisition, use or disposition of our assets that could have a material effect on the financial statements. Under the supervision and with the participation of our Chief Executive Officer and our Chief Financial Officer, management conducted an evaluation of the effectiveness of our internal control over financial reporting, as of December 31, 2012, based on the framework set forth in Internal Control-Integrated Frameworkissued by the Committee of Sponsoring Organizations of the Treadway Commission (COSO). Based on its evaluation under this framework, the Chief Executive Officer and the Chief Financial Officer concluded that our internal control over financial reporting was effective as of December 31, 2012. Internal control over financial reporting has inherent limitations. Internal control over financial reporting is a process that involves human diligence and compliance and is subject to lapses in judgment and breakdowns resulting from human failures. Internal control over financial reporting also can be circumvented by collusion or improper management override. Because of such limitations, there is a risk that material misstatements may not be prevented or detected on a timely basis by internal 33


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control over financial reporting. However, these inherent limitations are known features of the financial reporting process. Therefore it is possible to design into the process safeguards to reduce, though not eliminate, this risk. Attestation report of independent registered public accounting firm KPMG LLP, an independent registered public accounting firm, which audited and reported on our financial statements in this Report to Shareholders, has issued an unqualified attestation report on the effectiveness of our internal control over financial reporting as at December 31, 2012. Changes in Internal Controls Over Financial Reporting There have been no changes during fiscal 2012 in our internal control over financial reporting that have materially affected, or are reasonably likely to materially affect, our internal control over financial reporting. Changes in accounting policies: New standards and interpretations issued but not yet adopted: A number of new standards, interpretations and amendments to existing standards were issued by the IASB or International Financial Reporting Interpretations Committee (“IFRIC”). They are mandatory but not yet effective for the year ended December 31, 2012, and have not been applied in preparing these consolidated financial statements. Many of these are not applicable or are inconsequential to the Corporation and have been excluded from the discussion below. The following standards and interpretations have been issued by the IASB and the IFRIC and the Corporation is currently assessing their impact on the financial statements: IFRS 9 - Financial Instruments (“IFRS 9”)ultimately replaces IAS 39 - Financial Instruments: Recognition and Measurement (“IAS 39”). The replacement of IAS 39 is a three-phase project with the objective of improving and simplifying the reporting for financial instruments. The issuance of the first phase of the IFRS 9 provides guidance on the classification and measurement of financial assets and financial liabilities. IFRS 9 establishes two measurement categories for financial assets: amortized cost and fair value. Existing IAS 39 categories of loans and receivables, held-to-maturity investments, and available-for-sale financial assets have been eliminated. The criteria for a financial asset to be measured at amortized cost include: the objective of the business model is to hold assets in order to collect contractual cash flows; and, the contractual terms give rise, on contractual dates, to cash flows that are solely payments of principal and interest on principal outstanding. All other financial assets are measured at fair value. The Company intends to adopt IFRS 9 in its consolidated financial statements for the annual period beginning on January 1, 2015. The Company has not yet assessed the impact of the adoption of this standard on its consolidated financial statements, however does not expect that it will have a significant impact. IFRS 10 – Consolidated Financial Statements (”IFRS 10”)replaces SIC-12, Consolidation -Special Purpose Entities, and parts of IAS 27, Consolidated and Separate Financial Statements. The new standard builds on existing principles by identifying the concept of control as the determining factor in whether an entity should be included in a company’s consolidated financial statements. The standard provides additional guidance to assist in the determination of control where it is difficult to assess. The Company intends to adopt IFRS 10, including the amendments issued in June 2012, in its consolidated financial statements for the annual period beginning on January 1, 2013. The Company does not expect IFRS 10 to have a significant impact on the consolidated financial statements. IFRS 12 - Disclosure of Interests in Other Entities (“IFRS 12”)contains the disclosure requirements for entities that have interests in subsidiaries, joint arrangements (i.e. joint operations or joint ventures), associates and/or unconsolidated structured entities, aiming to provide information to enable users to evaluate: the nature of, and risks associated with, an entity's interests in other entities; andthe effects of those interests on the entity's financial position, financial performance and cash flows. The Company intends to adopt IFRS 12, including the amendments issued in June 2012, in its consolidated financial statements for the annual period beginning on January 1, 2013. The Company does not expect IFRS 12 to have a significant impact on the consolidated financial statements, because of the nature of the Company’s interests in other entities. IFRS 13 - Fair Value Measurement (“IFRS 13”)provides new guidance on fair value measurement and disclosure requirements. IFRS 13 replaces the fair value measurement guidance contained in individual IFRS with a single source of fair value measurement guidance. It defines fair value, establishes a framework for measuring fair value and sets out disclosure requirements for fair value measurements. It explains how to measure fair value when it is required or permitted by other IFRS. It does not introduce new requirements to measure assets or liabilities at fair value, nor does it eliminate the practicability exceptions to fair value measurements that currently exist in certain standards. 34


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The Company intends to adopt IFRS 13 prospectively in its consolidated financial statements for the annual period beginning on January 1, 2013. The Company does not expect IFRS 13 to have a significant impact on the consolidated financial statements. Forward Looking Statements Certain statements included in this MD&A may constitute “forward-looking statements” within the meaning of the U.S. Private Securities Litigation Reform Act of 1995and Canadian securities legislation and regulations, and are subject to important risks, uncertainties and assumptions. This forward-looking information includes amongst others, information with respect to our objectives and the strategies to achieve these objectives, as well as information with respect to our beliefs, plans, expectations, anticipations, estimates and intentions. Forward-looking statements generally can be identified by the use of forward-looking terminology such as “may”, “will”, “expect”, “intend”, “estimate”, “anticipate”, “plan”, “foresee”, “believe” or “continue” or the negatives of these terms or variations of them or similar terminology. We refer you to the Corporation’s filings with the Canadian securities regulatory authorities and the U.S. Securities and Exchange Commission, as well as the “Risk Factors” section of this MD&A, and of our Form 20-F, for a discussion of the various factors that may affect the Corporation’s future results. The results or events predicted in such forward-looking information may differ materially from actual results or events. Factors that could cause actual results or plans to differ materially from those projected in forward-looking statements made by, or on behalf of, the Corporation, many of which are beyond our control, include the Corporation’s ability to: identify and capitalize on possible collaboration, strategic partnering or divestiture opportunities;obtain suitable financing to support its operations and clinical trials;manage its growth and the commercialization of its products;achieve operating efficiencies as it progresses from a development-stage to a later-stage biotechnology corporation;successfully compete in its markets;realize the results it anticipates from the clinical trials of its products;succeed in finding and retaining joint venture and collaboration partners to assist it in the successful marketing, distribution and commercialization of its products;achieve regulatory clearances for its products;obtain on commercially reasonable terms adequate product liability insurance for its commercialized products and avoid product liability claims;adequately protect its proprietary information and technology from competitors and avoid infringement of proprietary information and technology of its competitors;assure that its products, if successfully developed and commercialized following regulatory approval, are not rendered obsolete by products or technologies of competitors; andnot encounter problems with third parties, including key personnel, upon whom it is dependent. Forward-looking statements do not take into account the effect that transactions or non-recurring or other special items announced or occurring after the statements are made have on the Corporation’s business. For example, they do not include the effect of business dispositions, acquisitions, other business transactions, asset writedowns or other charges announced or occurring after forward-looking statements are made. The financial impact of such transactions and non-recurring and other special items can be complex and necessarily depends on the facts particular to each of them. We believe that the expectations represented by our forward-looking statements are reasonable, yet there can be no assurance that such expectations will prove to be correct. Furthermore, the forward-looking statements contained in this report are made as of the date of this report, and we do not undertake any obligation to update publicly or to revise any of the included forward-looking statements, whether as a result of new information, future events or otherwise unless required by applicable legislation or regulation. The forward-looking statements contained in this report are expressly qualified by this cautionary statement. 35


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Research and Development, Patents and Licenses Nymox’s research and development policies are targeted at the development of novel therapeutic and diagnostic proprietary products that are subject to patent rights either directly owned by the Corporation or licensed to the Corporation through exclusive licensing agreements of patent rights. Over the last three financial years, the Corporation’s major research and development activities were in the following program areas: Diagnostic products for Alzheimer’s disease. The major project in this area, the development and validation of a kit version of our AlzheimAlertTM product for sale to laboratories and hospitals was completed in 2004 and the kit subsequently received the CE mark in Europe, allowing it to be marketed there. The FDA has not approved our kit version for sale in the U.S. We are continuing to pursue further kit development and regulatory approvals. At this time, we cannot provide an estimate of the costs and timing to obtain FDA approval for such a kit as it is uncertain at this stage the nature and extent of FDA requirements for approval based on discussions with us.Therapeutic products for enlarged prostate (benign prostatic hyperplasia or BPH) and prostate cancer.We have successfully completed several Phase 1 and Phase 2 multi-center, double-blind, placebo-controlled clinical trials, and follow-up studies, in the U.S. for NX-1207, our drug candidate for the treatment of BPH, and are presently in Phase 3. In March 2012, Nymox started a Phase 2 U.S. clinical trial to evaluate the company’s NX-1207 drug for the treatment of low grade localized prostate cancer. We cannot predict with any certainty the outcome of any future trials nor estimate the costs of completing such trials, given the inherent uncertainties in conducting clinical trials, including as yet unknown response rates to our treatment candidate, unforeseeable safety issues, patient enrollment rates, manufacturing costs, and regulatory requirements. We anticipate starting a Phase 3 trial in the near future and subsequently filing a New Drug Application (NDA) with the FDA.Given the inherent uncertainties with any Phase 3 clinical trial, we cannot provide a more precise estimate of the costs and timing of the completion of this project. These uncertainties include the chances of success of any phase of the clinical trials, the nature and extent of FDA requirements to proceed with a Phase 3 and for filing an NDA, our ability to scale up manufacture in accordance with current good manufacturing requirements (cGMP) and in sufficient quantities for commercial use, and whether or when the FDA will ultimately grant us such approval.Anti-infectives.Our anti-bacterial agent, NXC-4720, which is being developed as a treatment of meat at the processing stage, has shown to be capable of substantially reducing the level of potentially fatal E. coli O157:H7 contamination on fresh beef according to laboratory studies. Other projects in this area, such as treating E. coli O157:H7 infection in livestock and treating bacterial infections in humans, are in preliminary stages of development with more uncertain prospects and timing and course of development. Because of the early stage of development of this project, it is impossible to outline the nature, timing or estimated costs of the efforts necessary to complete this project or the anticipated completion dates for this project.The facts and circumstances indicating the uncertainties that preclude us from making a reasonable estimate of the costs and timing necessary to complete this project include the risks inherent in any field trials of NXC-4720, the uncertainty as to the nature and extent of regulatory requirements both for safety and efficacy, and the ability to manufacture NXC-4720 in accordance with current good manufacturing requirements (cGMP) and in sufficient quantities both for large scale trials and for commercial use. In addition, we anticipate that we may need to partner with a larger Corporation in the food or agricultural sectors in order to finance and conduct field trials and to market any approved product; thus the timing of completion of the regulatory approval of such a product will not likely be within our sole control.Tobacco exposure and other diagnostic tests.We developed and validated NicAlertTM, which is an FDA-cleared test for tobacco product use, and TobacAlertTM, which is an over-the-counter test for second-hand smoke exposure. These are completed projects with any further research and development costs being related to product improvement and obtaining regulatory approvals where required in order to expand the market for these products. The development of other new diagnostic tests using our patented diagnostic technologies are in early stage development. Because of the early stage of development of these projects, it is not possible to outline the nature, timing or estimated costs of the efforts necessary to complete any of them nor their anticipated completion dates. The facts and circumstances indicating the uncertainties that preclude us from making a reasonable estimate include the uncertainty about whether we will be able to successfully adapt our patented diagnostic technologies to these new diagnostic indicators, whether any new diagnostic tests we develop will pass proof-of-principle testing both in the laboratory and in clinical trials, and whether we will be able to manufacture such tests at a commercially competitive price.Therapeutic products for Alzheimer’s disease.We are conducting early stage research and development work into preclinical development of novel drug candidates and original research into the role spherons play in the Alzheimer’s disease process in order to pursue spheron-based therapeutics. Because of the early stage of development of this project, it is impossible to outline the nature, timing or estimated costs of the efforts necessary to complete this project, nor the anticipated completion dates for this project. The facts and circumstances indicating the uncertainties that preclude us from making a reasonable estimate include the inherent uncertainties in the pre-clinical and clinical development of therapeutic candidates. In addition, given the very high costs of development of a drug for Alzheimer’s disease, we anticipate having to partner with a larger pharmaceutical corporation to conduct and finance clinical trials. The terms of such a partnership arrangement along with our related financial obligations cannot be determined at this time and the timing of completion of the approval of such a drug will likely not be within our sole control. Most pre-clinical drug candidates do not meet necessary milestones to enter clinical trials; of those which do, only a small percentage ultimately achieve regulatory approval and enter the marketplace. We also have global patent rights to the use of statins in the prevention or treatment of Alzheimer’s disease. Various published epidemiological and other research studies have shown evidence that statins may help in the prevention or treatment of Alzheimer’s disease; other studies have shown otherwise. Other companies and organizations are currently carrying out 36


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clinical trials into the use of statin drugs for Alzheimer’s disease. The effect of the results of such trials on this program is uncertain. Research and development expenses, excluding stock-based compensation and depreciation expenses, allocated to our major research and development programs are as follows: Year ended

   

   

   Year ended

   

   

   Year endedDec 31, 2012

   

   

   Dec 31, 2011

   

   

   Dec 31, 2010Alzheimer’s Disease: Diagnostics

   

   $41,688

   

   

   $44,509

   

   

   $71,932Alzheimer’s Disease: Therapeutics

   

   $8,562

   

   

   $21,595

   

   

   $18,744Anti-Infectives

   

   $9,787

   

   

   $8,243

   

   

   $5,091**BPH (Enlarged Prostate) and Prostate Cancer Therapeutics**

   

   $6,511,143

   

   

   $6,519,377

   

   

   $4,448,857**Tobacco Exposure Tests:** **NicAlertTM and TobacAlertTM**

   

   $14,859

   

   

   $8,424

   

   

   $7,095Total

   

   $6,586,039

   

   

   $6,602,148

   

   

   $4,551,719
 For the earlier periods from 1995 to 1998, the Corporation did not maintain a cost accounting system that tracked research and development costs on a project-by-project basis. During the initial discovery stages, research and development is more general in nature and cannot be specifically categorized. During the periods 1995 to 2001, the general research expenses related primarily to the development of diagnostic products and therapeutic candidates for Alzheimer’s disease. From 2002 to 2004, expenses related primarily to R&D in the areas of Alzheimer’s disease and in BPH. Since 2005, expenses have primarily related to the development and clinical trials of NX-1207, our candidate for the treatment of BPH. The breakdown of research and development costs for these periods is as follows: 2009: $3,043,219; 2008: $2,388,911; 2007: $3,468,273; 2006: $3,171,428; 2005: $2,292,610. The total research and development expenditures for the 1995 to 2004 period were $18,507,409. Total research and development expenditures to date, excluding stock-based compensation and depreciation expenses, are $50,611,756 The Corporation expenses all research and development costs as incurred but does not currently maintain a cost accounting system to track, record and allocate staffing time on a specific project-by-project basis. We manage our ongoing research and development projects and programs in a dynamic, flexible manner. Our researchers, staff and management are typically involved in more than one of our research and development projects and the percentage of time an employee may be involved in a project varies according to the changing needs and progress of that project. As well, a significant portion of the Corporation's research and development expenses, such as laboratory supplies, travel, information systems and services and facilities costs, benefit multiple projects and are not necessarily individually tracked or allocated to a specific project when incurred. Research and development costs are allocated in reasonable and realistic proportion to the projects that benefited from those costs. According to industry statistics, on average it takes 10 to 15 years to research, develop and bring to market a new prescription medicine in the United States. In light of the steps and complexities involved, the successful development of our product candidates is highly uncertain. Actual product timelines and costs are subject to enormous variability and are very difficult to predict. Accordingly, we cannot provide reliable estimates of the nature, timing and estimated costs of the efforts necessary to complete our programs. This is particularly the case for our programs in early stage development. The risk of failure to complete any such program is high because of uncertain feasibility and commercial viability, long lead times to program completion and potentially high costs in relation to anticipated returns. We update and change our product development programs to reflect the most recent preclinical and clinical data and other relevant information. Many of our products under development require regulatory approval before being sold. The process of obtaining such approvals is often lengthy and uncertain and requires the expenditure of substantial resources. Any failure by us to obtain, or any delay in obtaining, regulatory approvals could materially adversely affect our business. We cannot assure you that any such approvals required will be obtained on a timely basis, if at all. Trend Information The Corporation does not currently know of any trends that would be material to our operations other than those disclosed in Items 4 and 5. 37


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ITEM 6. DIRECTORS, SENIOR MANAGEMENT AND EMPLOYEES Directors and Senior Management Paul Averback, M.D., D.A.B.P., 62, President and Director since September 1995 and Chairman since June of 2001, is the founder of Nymox and the inventor of much of its initial technology. Prior to founding Nymox, Dr. Averback served as President of Nymox’s predecessor, DMS Pharmaceuticals Inc. He received his M.D. in 1975 and taught pathology at universities, including Cambridge University, England (1977-1980), during which time he initiated his research on Alzheimer’s disease. He has practised medicine in numerous institutions as well as in private practice. Dr. Averback has published extensively in the scientific and medical literature. Randall Lanham, Esquire, 49, has been a director since June 8, 2006. He attained his Juris Doctor from Whittier College School of Law in 1991 and a Bachelor of Science degree from the University of Delaware in 1987. Mr. Lanham has vast experience in both domestic and international corporate legal matters. Currently Mr. Lanham manages his own law office in California specializing in corporate mergers and acquisitions. In addition, Mr. Lanham has a broad base of entrepreneurial experience and currently owns and operates several small entertainment companies. Paul F. McDonald, 87, has been a director since June 8, 2006. A graduate in law of McGill University, he has had a long and varied career as a member of the Canadian investment industry. Mr. McDonald was previously Vice-President of the Montreal Exchange, and he was principal owner and president of a stock exchange firm. His principal focus has been in the financing and development of growth companies in the high-tech and resources sectors, and he has had numerous appointments to corporate boards. He has devoted much time to committee work in the investment sector, as well as to public affairs, including a lengthy tenure as a director of the Quebec Industrial Development Corporation. Mr. McDonald currently works as a private consultant. Professor David Morse, Ph.D., 56, has been a director since June 8, 2006. He is a world expert in the biochemistry, proteomics and genomics of cell function particularly as it relates to circadian regulation in single cell organisms. He received a Ph.D. from McGill University in 1984, completed a post-doctoral fellowship at Harvard University in 1989 and has been a Full Professor at the University of Montreal since 2001. He has published extensively in the peer-reviewed scientific literature, including papers in journals such as Science, Cell, Proceedings of the National Academy of Science, Journal of Biological Chemistry, and Nature. Dr. Morse has previously collaborated with Nymox scientists in research and development projects. Roger Guy, M.D., 62, has been a director since June 8, 2006. He received his B.Sc., M.Sc. and M.D degrees from Memorial University of Newfoundland. He is a highly experienced medical doctor who has served as a national examiner. Dr. Guy has broad human clinical trial and business experience. Jack Gemmell, 61, has been a Director since June, 2001 and is Nymox’s General Counsel and Chief Information Officer. He graduated from the Faculty of Law at the University of Toronto in 1977 and was called to the bar in 1979. He practiced in private practice primarily in the area of litigation for over 19 years before joining Nymox in July, 1998. Roy M. Wolvin, 58, has been Secretary-Treasurer and Chief Financial Officer since September 1995. Prior to September 1995, Mr. Wolvin was Account Manager, private business, for a Canadian chartered bank. Mr. Wolvin holds a degree in Economics from the University of Western Ontario. Brian Doyle, B.Sc., M.B.A., 58, has been Senior Manager Global Sales and Marketing since May 2003. He received his B.Sc. in Microbiology and Immunology from McGill University, in 1979. He worked in the Experimental Surgery department at McGill in cancer research, before completing his MBA at Concordia University, in 1983. He has wide sales, marketing and merchandising experience and spent 15 years at a technical sales representative firm, where he was National Sales Manager before joining Nymox. Compensation Named Executive Officers The Summary Compensation Table and Outstanding Incentive Plan Awards tables below for Named Executive Officers summarize the total compensation paid during the Corporation’s financial year ending on December 31, 2012 to the Named Executive Officers of the Corporation and all incentive plan awards outstanding at December 31, 2012 for the Named Executive Officers: The Named Executive Officers are the Corporation’s Chief Executive Officer, Chief Financial Officer, and three most highly compensated executive officers. During the financial year ended December 31, 2012, one executive received an option grant totaling 500,000 options. No executive officer received any other share-based awards, or any bonuses or other non-equity incentive compensation. The Corporation does not have a share-based incentive plan, non-equity incentive plan or pension plan for its executive officers. The Corporation has not made any agreements or arrangements with any of its executive officers in connection with any termination or change of employment or change of control of the Corporation. 38


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Compensation Discussion and Analysis The Human Resources and Compensation Committee of the Board of Directors oversees the compensation of executive officers of the Corporation. The members of the Human Resources and Compensation Committee for the financial year ending December 31, 2012 were Dr. Roger Guy, Paul McDonald and Randall Lanham, Esq.. The Corporation’s current compensation policy for its executive officers, including the Chief Executive Officer and the Named Executive Officers, emphasizes the granting of options over base salary as a means of attracting, motivating and retaining talented individuals. Such a policy is believed to better further the Corporation’s business goals by allocating more financial resources to the Corporation’s ongoing product development programs. Given the current stage of the Corporation’s development, the Corporation has not established and does not use formal benchmarks, performance goals, review processes or other qualitative or quantitative criteria or targets relating to the performance of the Corporation or the individual in order to determine compensation. The Corporation does not have a non-equity incentive plan or a policy of annually granting performance bonuses or salary increases to its executive officers. The Corporation grants option-based awards to its executive officers in accordance with a stock option plan approved by the shareholders. Further details of the stock option plan are provided below. The stock option plan provides long-term incentives to the Corporation’s officers and employees to advance the Corporation’s drug development programs towards commercialization and to enhance shareholder value. The Corporation endeavours to provide salaries and option grants that are internally equitable and that are consistent with both job performance and ongoing progress towards corporate goals. The amount of option grants is determined in part by the amount and terms of outstanding and expiring options, the experience and expertise of each executive officer and the needs of the Corporation, among other factors. The Human Resources and Compensation Committee of the Board of Directors reviews all proposals for awards of stock options to executive officers and decides on the appropriateness of the awards. In doing so, the Committee relies solely on discussion among the independent board members on the Committee without any formal pre-determined objectives, criteria or analytic processes but with a view to attracting and retaining executive officers who can help further the Corporation’s business plan. By relying on option grants as a primary means of compensating its executive officers, the Corporation’s intention is to provide a direct link between corporate performance and executive compensation while maximizing shareholder value and controlling cash expenditures. Directors The Summary Compensation Table and Outstanding Incentive Plan Awards tables below for the directors of the Corporation summarize the total compensation paid during the Corporation's financial year ending on December 31, 2012 to the directors of the Corporation and all incentive plan awards outstanding at December 31, 2012 for the directors. Two current directors, Dr. Paul Averback, the President and CEO of the Corporation, and Jack Gemmell, General Counsel, are members of the senior management of the Corporation and do not receive any compensation for acting as a director. Their compensation as Named Executive Officers is summarized in the summary tables for compensation and incentive plans for Named Executive Officers below. Summary Compensation Table: Named Executive Officers Name andprincipal position

   Year

   Salary

   Share-basedawards

   Option-basedawards(#)

   Non-equity incentiveplan compensation

   Pensionvalue

   All OtherCompensation

   TotalCompensation($)Annualincentiveplans

   Long-termincentiveplansDr. Paul AverbackCEO andPresident

   2012

   $190,000

   

   500,000

   

   

   

   

   $190,000Roy WolvinCFO

   2012

   $150,063

   

   

   

   

   

   

   $150,063Brian DoyleGlobal SalesManager

   2012

   $160,846

   

   

   

   

   

   

   $160,846Jack GemmellGeneral Counsel,CIO

   2012

   $165,069

   

   

   

   

   

   

   $165,069
 Salaries are payable in Canadian dollars, but expressed above in US$. 39


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Outstanding Incentive Plan Awards as of December 31, 2012: Named Executive Officers Name

   Option-based AwardsNumber of securities underlyingunexercised options

   Option exercise price

   Optionexpiration date(mm/dd/yy)

   Value of unexercised in-the-money optionsTotal

   Unvested

   VestedDr. PaulAverback

   500,000

   

   500,000

   $3.00

   10/24/13

   $1,930,0003,000,000

   

   3,000,000

   $3.00

   08/24/16

   $11,580,000500,000

   

   500,000

   $7.08

   01/24/21

   $0500,000

   

   500,000

   $6.51

   10/15/22

   $175,000Roy Wolvin

   50,000

   

   50,000

   $2.82

   06/09/16

   $202,000150,000

   

   150,000

   $3.00

   08/24/16

   $579,00020,000

   

   20,000

   $3.65

   05/14/19

   $64,20020,000

   

   20,000

   $7.08

   01/24/21

   $0Jack Gemmell

   20,000

   

   20,000

   $2.62

   09/09/13

   $84,800210,000

   

   210,000

   $3.00

   08/24/16

   $810,60050,000

   

   50,000

   $3.30

   01/23/19

   $178,00025,000

   

   25,000

   $3.40

   05/03/20

   $86,500170,000

   

   170,000

   $7.08

   01/24/21

   $0Brian Doyle

   50,000

   

   50,000

   $3.75

   04/28/13

   $155,50050,000

   

   50,000

   $3.00

   08/24/16

   $193,000100,000

   

   100,000

   $7.08

   01/24/21

   $0
 Option exercise prices and the values of unexercised in-the-money options are expressed in US$. The Corporation does not have a share-based award plan. Summary Compensation Table: Directors Name

   Year

   FeesEarned

   Share-basedawards

   Option-basedawards (#)

   Non-equityincentive plancompensation

   Pensionvalue

   All othercompensation

   Total($)Paul McDonald

   2012

   $16,500

   

   10,000

   

   

   

   $16,500Randall Lanham, Esq.

   2012

   $16,500

   

   10,000

   

   

   

   $16,500Roger Guy, MD

   2012

   $16,500

   

   10,000

   

   

   

   $16,500David Morse, Ph.D.

   2012

   $14,500

   

   10,000

   

   

   

   $14,500
 Outstanding Incentive Plan Awards as of December 31, 2012: Directors Name

   Option-based AwardsNumber of securities underlyingunexercised options

   Option exercise price

   Option expiration date

   Value of unexercisedPaul McDonald

   10,000

   $5.95

   08/23/17

   $9,10010,000

   $3.61

   07/16/18

   $32,50010,000

   $4.83

   07/09/19

   $20,30010,000

   $2.90

   07/16/20

   $39,60010,000

   $9.10

   07/16/21

   $010,000

   $6.88

   07/16/22

   $0Randall Lanham, Esq.

   10,000

   $2.74

   07/17/16

   $41,20010,000

   $5.95

   08/23/17

   $9,10010,000

   $3.61

   07/16/18

   $32,50010,000

   $4.83

   07/09/19

   $20,30010,000

   $2.90

   07/16/20

   $39,60010,000

   $9.10

   07/16/21

   $010,000

   $6.88

   07/16/22

   $0Roger Guy, MD

   10,000

   $2.74

   07/17/16

   $41,20010,000

   $5.95

   08/23/17

   $9,10010,000

   $3.61

   07/16/18

   $32,50010,000

   $4.83

   07/09/19

   $20,30010,000

   $2.90

   07/16/20

   $39,60010,000

   $9.10

   07/16/21

   $010,000

   $6.88

   07/16/22

   $0David Morse, Ph.D.

   10,000

   $2.74

   07/17/16

   $41,20010,000

   $5.95

   08/23/17

   $9,10010,000

   $3.61

   07/16/18

   $32,50010,000

   $4.83

   07/09/19

   $20,30010,000

   $2.90

   07/16/20

   $39,60010,000

   $9.10

   07/16/21

   $010,000

   $6.88

   07/16/22

   $0
 During the same period from 2000 to 2012, the salaries of Named Executive Officers increased from $465,805US (2000) to $665,978US (2012), an increase of 3.3% per annum over that thirteen year period, or 43.0% in total. During the same period, the Corporation’s stock price has increased approximately 254%. 40


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Share Ownership As of March 15, 2013, the number of common shares owned or controlled by directors and senior officers of the Corporation were as follows: Common Shares

   Percentage of CommonOwned and

   Shares Owned andName

   Controlled

   ControlledPaul Averback, M.D.

   12,239,914

   36.3%Randall Lanham, Esq.

   0

   *Paul McDonald

   0

   *David Morse, Ph.D.

   396

   *Roger Guy, MD

   51,979

   *Jack Gemmell

   33,725

   *Jack Gemmell Trustee

   607,0311

   1.8%Roy Wolvin

   13,920

   *Brian Doyle

   10,000

   *
  * Denotes less than 1%.1) As joint trustee of a family trust. Options Nymox has created a stock option plan for its employees, officers and directors, and for consultants. The board of directors of Nymox administers the stock option plan and authorizes the granting of options in accordance with the terms of the plan. Each option gives the individual granted the option the right to purchase a common share of the Corporation at a fixed price during a specified period of no more than ten years. The board may also make all or a portion of the options granted effective only as of a specific future date or dates. The option price must not be less than the market price of the common shares when the option is granted. The total number of shares under option to any one individual may not exceed fifteen percent of the total number of issued and outstanding common shares of the Corporation. The options may not be assigned, transferred or pledged, and expire within three months of the termination of employment or active office with the Corporation and six months of the death of the individual. No more than 7,500,000 common shares may be under option at any time and a maximum of 7,500,000 common shares are available to be issued under the stock option plan as the result of the exercise of options. Options that expire or terminate without being exercised become available to be granted again. Material changes to the stock option plan such as the number of shares available to be optioned require shareholder approval. On June 13, 2011, the shareholders approved amendments to the plan that included increasing the maximum number of shares that could be issued in total under the plan from 5,500,000 to 7,500,000. Since the inception of the stock option plan in 1995, 382,400 options have been exercised under the plan and 70,559 shares have been issued as a result of cashless exercises. Board Practices Directors are elected at each annual meeting for a term of office until the next annual meeting. Executive officers are appointed by the board of directors and serve at the pleasure of the board. Other than Dr. Averback, no other officer or director previously was affiliated with DMS Pharmaceuticals Inc. Nymox does not have written contracts with any of the directors named above. We do not have any pension plans or other type of plans providing retirement or similar benefits for directors, nor any benefits upon termination of service as a director. Nymox’s Audit Committee consists of three directors appointed by the Board who are independent of management and who are generally knowledgeable in financial and auditing matters. The Chairman of the Audit Committee is Paul McDonald; the other members are Randall Lanham, Esq. and Dr. Roger Guy. The primary role of the Audit Committee is to provide independent oversight of the quality and integrity of the accounting, auditing, and reporting practices of Nymox with a particular focus on financial statements and financial reporting to shareholders. The Committee is responsible for the appointment, compensation, and oversight of the public accounting firm engaged to prepare or issue an audit report on our financial statements. It oversees all relationships between Nymox and the auditor, including reviewing on an ongoing basis any non-audit services and special engagements that may impact the objectivity or independence of the auditors. The auditors report directly to the Audit Committee. The Audit Committee reviews the scope and results of the audit with the independent auditors. The Audit Committee meets at least four times a year to review with management and the independent auditors the Corporation's interim and year-end financial condition and results of operations. Its review includes an assessment of the adequacy of the internal accounting, bookkeeping and control procedures of the Corporation. The Audit Committee also has 41


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the responsibility for reviewing on an ongoing basis all material transactions between Nymox and its affiliates and other related parties such as officers, directors, other key management personnel, major shareholders and their close family members, affiliated companies or associated enterprises. The Audit Committee has the power to conduct or authorize investigations into any matters within the Committee's scope of responsibilities, including the power and authority to retain and determine funding for independent counsel, accountants, or other advisors as it determines necessary to carry out its duties. The Human Resources and Compensation Committee consists of the independent directors of the Board. The Chairman of the Committee is Dr. Roger Guy; the other members are Randall Lanham, Esq., Dr. David Morse and Paul McDonald. The Committee establishes and reviews overall policy and structure with respect to compensation and employment matters, including the determination of compensation arrangements for directors, executive officers and key employees of the Corporation. The Committee is also responsible for the administration and award of options to purchase shares pursuant to our share option plan. The Corporate Governance Committee consists of the independent directors of the Board. The Chairman of the Committee is Randall Lanham, Esq.; the other members are Paul McDonald, Dr. Roger Guy and Dr. David Morse. This Committee has the general mandate of providing an independent and regular review of the management, business and affairs of Nymox, including our corporate governance. This Committee also reviews and approves director nominations to ensure each nominee meets the requisite requirements under applicable corporate and securities laws, rules and regulations and otherwise possesses the skills, judgment and independence appropriate for a director of a public corporation. Employees In addition to the employees in its Hasbrouck Heights and St. Laurent laboratories and offices, Nymox carries out its work with the assistance of an extensive group of research collaborators, out-sourced manufacturing teams, research suppliers, research institutions, service providers and research consultants. To help carrying out its marketing, Nymox has independent medical representatives detailing its products. In its Hasbrouck Heights and St. Laurent laboratories and offices, for the year 2012, the Corporation employed on the average twenty persons with sixteen in research and development and four in administration and marketing; for the year 2011, the Corporation employed on the average twenty-six persons (twenty-two in research and development and four in administration and marketing); for the year 2010, the Corporation employed on the average twenty-two persons (eighteen in research and development and four in administration and marketing). ITEM 7. MAJOR SHAREHOLDERS AND RELATED PARTY TRANSACTIONS Major Shareholders The following table sets out as of March 15, 2013, the number of common shares owned and controlled by Dr. Paul Averback, the President and CEO of Nymox and a member of the Nymox board of directors, and by all directors and officers as a group. Number of Common Shares

   

   Percent of Class ofName of Shareholder

   

   owned by Shareholder

   

   Common SharesDr. Paul Averback

   

   12,239,914

   

   36.3%All directors and officers as a group

   

   12,349,934

   

   36.6%
 The above shareholders have the same voting rights as all other shareholders. There has been no significant change in ownership for any of the persons listed above over the past three years. Hal Pettigrew reported in a February 15, 2011 filing that he had dispositive power over 2,647,586 shares of Nymox or approximately 8.2% of Nymox’s shares. Michael Starcher reported in a February 15, 2011 filing that he had dispositive power over 1,952,007 shares of Nymox or approximately 6.02% of Nymox’s shares. The number of shares owned by Hal Pettigrew represented an increase of 252,486 shares from the number of shares reported as beneficially owned in the Schedule 13G filed with the Securities and Exchange Commission on March 31, 2010. The number of shares owned by Michael Starcher represented an increase of 157,007 shares from the number of shares reported as beneficially owned in the Schedule 13G filed with the Securities and Exchange Commission on November 20, 2008. All shareholders of Nymox stock have the same voting rights. Other than Dr. Paul Averback and the individuals above, Nymox does not know of any other shareholders that beneficially own or hold dispositive power over more than 5% of its shares. According to information furnished to Nymox by the transfer agent for the common shares, as of March 15, 2013, total shares outstanding were 33,731,492; there were 175 holders of record of the common shares and 5,020 beneficial shareholders in total. Of these, 59 were holders of record of the common shares and 4,044 were beneficial shareholders with addresses in the United States and such holders owned an aggregate of 18,406,429 shares, representing approximately 54.58% of the outstanding shares of common stock. 42


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Related Party Transactions The Corporation did not have any related party transactions for the years ended December 31, 2012, 2011 and 2010. Refer to Note 18 of the consolidated financial statements for key management personnel disclosures. ITEM 8. FINANCIAL INFORMATION In 2012, revenues of Nymox Pharmaceutical Corporation’s US subsidiaries were $353,397 and revenues of its Canadian Corporation were $2,725,370 (including Europe and other). We refer to Note 17 of the financial statements below. Dividends The Corporation has not issued dividends since inception. Cease Trade Orders, or Bankruptcies To the knowledge of the Corporation, no director or officer of the Corporation or shareholder of the Corporation holding a sufficient number of securities of the Corporation to affect materially the control of the Corporation is, or has been within the past 10 years, a director or officer of any other Corporation that, while such person was acting in that capacity, was the subject of a cease trade or similar order or an order that denied such Corporation access to any exemptions under Canadian securities legislation for a period of more than 30 consecutive days, or was declared bankrupt or made a voluntary assignment in bankruptcy, made a proposal under any legislation relating to bankruptcy or insolvency or was subject to or instituted any proceedings, arrangement or compromise with creditors or had a receiver, receiver manager or trustee appointed to hold its assets. Penalties or Sanctions To the knowledge of the Corporation, no director, officer or control person of the Corporation has been subject to any penalties or sanctions imposed by a court relating to U.S. or Canadian securities legislation or by a U.S. or Canadian securities regulatory authority or has entered into a settlement agreement with a U.S. or Canadian securities authority, nor has any director, officer or control person of the Corporation been subject to any penalties or sanctions imposed by a court or regulatory body that would likely be considered important to a reasonable investor in making an investment decision. Personal Bankruptcies To the knowledge of the Corporation, no director, officer or control person of the Corporation, nor any personal holding Corporation of any such person, has within the past 10 years, been declared bankrupt or made a voluntary assignment in bankruptcy, made a proposal under any legislation relating to bankruptcy or insolvency or been subject to or instituted any proceedings, arrangement or compromise with creditors, or had a receiver, receiver manager or trustee appointed to hold the assets of that individual. Conflicts of Interest To the knowledge of the Corporation, there are no existing or potential material conflicts of interest between the Corporation, or subsidiary of the Corporation, and any director, officer or control person of the Corporation. Legal Proceedings In November 2011, two former directors of Nymox, who ceased to be directors in 2006, served Nymox with a Motion to Institute Proceedings filed with the Quebec Superior Court seeking orders that they are entitled to exercise options to purchase a total of 125,000 shares of Nymox at a price of $4.33 U.S. or in the alternative damages for lost profit. Nymox believes that the right to exercise these options ended in May 2007 and that the claims are without merit. Nymox intends to defend the action vigorously. Accordingly, no provision related to this matter has been recorded in the financial statements. 43


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Consolidated Financial Statements of NYMOX PHARMACEUTICAL CORPORATION As of December 31, 2012 and 2011, and for each of the years in the three-year period ended December 31, 2012 44


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KPMG LLP

   Telephone

   (514) 840-2100600 de Maisonneuve Blvd. West

   Fax

   (514) 840-2187Suite 1500

   Internet

   www.kpmg.caTour KPMGMontréal, Québec H3A 0A3
 REPORT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM To the Shareholders and Directors of Nymox Pharmaceutical Corporation We have audited the accompanying consolidated statements of financial position of Nymox Pharmaceutical Corporation as of December 31, 2012 and December 31, 2011 and the related consolidated statements of operations and comprehensive loss, changes in equity and cash flows for each of the years in the three-year period ended December 31, 2012. These consolidated financial statements are the responsibility of Nymox Pharmaceutical Corporation's management. Our responsibility is to express an opinion on these consolidated financial statements based on our audits. We conducted our audits in accordance with Canadian generally accepted auditing standards and the standards of the Public Company Accounting Oversight Board (United States). Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the financial statements are free of material misstatement. An audit includes examining, on a test basis, evidence supporting the amounts and disclosures in the financial statements. An audit also includes assessing the accounting principles used and significant estimates made by management, as well as evaluating the overall financial statement presentation. We believe that our audits provide a reasonable basis for our opinion. In our opinion, the consolidated financial statements referred to above present fairly, in all material respects, the consolidated financial position of Nymox Pharmaceutical Corporation as of December 31, 2012 and 2011, and its consolidated financial performance and its consolidated cash flows for each of the years in the three-year period ended December 31, 2012 in conformity with International Financial Reporting Standards as issued by the International Accounting Standards Board. We also have audited, in accordance with the standards of the Public Company Accounting Oversight Board (United States), Nymox Pharmaceutical Corporation’s internal control over financial reporting as of December 31, 2012, based on the criteria established in Internal Control – Integrated Framework issued by the Committee of Sponsoring Organizations of the Treadway Commission (COSO), and our report dated March 1, 2013 expressed an unqualified opinion on the effectiveness of Nymox Pharmaceutical Corporation’s internal control over financial reporting. /s/ KPMG LLP March 1, 2013 Montréal, Canada *CPA auditor, CA, public accountancy permit No. A120841KPMG LLP is a Canadian limited liability partnership and a member firm of the KPMGnetwork of independent member firms affiliated with KPMG International Cooperative(“KPMG International”), a entity.KPMG Canada provides services to KPMG LLP.
 45


---

KPMG LLP

   Telephone

   (514) 840-2100600 de Maisonneuve Blvd. West

   Fax

   (514) 840-2187Suite 1500

   Internet

   www.kpmg.caTour KPMGMontréal, Québec H3A 0A3
 REPORT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM To the Shareholders and Directors of Nymox Pharmaceutical Corporation We have audited Nymox Pharmaceutical Corporation's internal control over financial reporting as at December 31, 2012, based on the criteria established in Internal Control - Integrated Frameworkissued by the Committee of Sponsoring Organizations of the Treadway Commission (COSO). Nymox Pharmaceutical Corporation's management is responsible for maintaining effective internal control over financial reporting and for its assessment of the effectiveness of internal control over financial reporting as presented in the section entitled “Management’s Annual Report on Internal Control over Financial Reporting” included in Management’s Discussion and Analysis. Our responsibility is to express an opinion on Nymox Pharmaceutical Corporation's internal control over financial reporting based on our audit. We conducted our audit in accordance with the standards of the Public Company Accounting Oversight Board (United States). Those standards require that we plan and perform the audit to obtain reasonable assurance about whether effective internal control over financial reporting was maintained in all material respects. Our audit included obtaining an understanding of internal control over financial reporting, assessing the risk that a material weakness exists, and testing and evaluating the design and operating effectiveness of internal control based on the assessed risk. Our audit also included performing such other procedures as we considered necessary in the circumstances. We believe that our audit provides a reasonable basis for our opinion. A company's internal control over financial reporting is a process designed to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles. A company's internal control over financial reporting includes those policies and procedures that (1) pertain to the maintenance of records that, in reasonable detail, accurately and fairly reflect the transactions and dispositions of the assets of the company; (2) provide reasonable assurance that transactions are recorded as necessary to permit preparation of financial statements in accordance with generally accepted accounting principles, and that receipts and expenditures of the company are being made only in accordance with authorizations of management and directors of the company; and (3) provide reasonable assurance regarding prevention or timely detection of unauthorized acquisition, use, or disposition of the company's assets that could have a material effect on the financial statements. Because of its inherent limitations, internal control over financial reporting may not prevent or detect misstatements. Also, projections of any evaluation of effectiveness to future periods are subject to the risk that controls may become inadequate because of changes in conditions, or that the degree of compliance with the policies or procedures may deteriorate.  KPMG LLP is a Canadian limited liability partnership and a member firm of the KPMG network of independent member firms affiliated with KPMG International Cooperative (“KPMG International”), a Swiss entity.KPMG Canada provides services to KPMG LLP. 46


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Page 2  In our opinion, Nymox Pharmaceutical Corporation maintained, in all material respects, effective internal control over financial reporting as of December 31, 2012, based on the criteria established in Internal Control - Integrated Frameworkissued by the Committee of Sponsoring Organizations of the Treadway Commission (COSO). We also have audited, in accordance with Canadian generally accepted auditing standards and the standards of the Public Company Accounting Oversight Board (United States), the consolidated statements of financial position of Nymox Pharmaceutical Corporation as of December 31, 2012 and 2011 and the related consolidated statements of operations and comprehensive loss, changes in equity and cash flows for each of the years in the three year period ended December 31, 2012, and our report dated March 1, 2013 expressed an unqualified opinion on those consolidated financial statements. /s/ KPMG LLP March 1, 2013 Montréal, Canada  *CPA auditor, CA, public accountancy permit No. A120841 47


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NYMOX PHARMACEUTICAL CORPORATIONConsolidated Financial Statements As of December 31, 2012 and 2011, and for each of the years in the three-year period ended December 31, 2012 Financial StatementsConsolidated Statements of Financial Position

   49Consolidated Statements of Operations and Comprehensive Loss

   50Consolidated Statements of Changes in Equity

   51Consolidated Statements of Cash Flows

   52Notes to Consolidated Financial Statements1.

   Business activities

   532.

   Basis of preparation

   533.

   Significant accounting policies

   554.

   Changes in accounting policies

   635.

   Property and equipment

   666.

   Intangible assets

   667.

   Licensing revenues and deferred revenue

   678.

   Preferred shares of a subsidiary and non-controlling interest

   679.

   Share capital

   6710.

   Commitments and contingencies

   7211.

   Cost of sales

   7312.

   Research tax credits and grants and income taxes

   7313.

   Earnings per share

   7714.

   Capital disclosures

   7715.

   Financial risk management

   7816.

   Financial instruments

   8117.

   Segment disclosures

   8118.

   Related parties

   8219.

   Personnel expenses

   8220.

   Subsequent events

   82
 48    NYMOX PHARMACEUTICAL CORPORATIONConsolidated Statements of Financial PositionDecember 31, 2012 and 2011(In US dollars)
  Note
        
        2012
        
        
        2011AssetsCurrent assets:Cash
        
        $
        1,030,075
        
        $
        5,918,921Trade accounts receivable
        
        
        30,732
        
        
        31,546Other receivables
        
        
        54,169
        
        
        119,192Research tax credits receivable
        
        
        532,198
        
        
        242,431Prepaid expenses
        
        
        31,988
        
        
        –Security deposit
        
        
        17,396
        
        
        –Inventories
        
        
        42,503
        
        
        23,620Total current assets
        
        
        1,739,061
        
        
        6,335,710Non-current assets:Long-term security deposit
        
        
        –
        
        
        17,396Property and equipment
        5
        
        15,118
        
        
        22,160Total non-current assets
        
        
        15,118
        
        
        39,556Total assets
        
        $
        1,754,179
        
        $
        6,375,266Liabilities and EquityCurrent liabilities:Trade accounts payable
        
        $
        880,533
        
        $
        640,507Accrued liabilitiesPayroll related liabilities
        
        
        14,388
        
        
        4,102Other accrued liabilities
        
        
        160,238
        
        
        166,883Deferred revenue
        7
        
        2,617,600
        
        
        2,617,600Total current liabilities
        
        
        3,672,759
        
        
        3,429,092Non-current liabilities:Deferred revenue
        7
        
        5,126,133
        
        
        7,743,733Preferred shares of a subsidiary
        8
        
        400,000
        
        
        400,000Total non-current liabilities
        
        
        5,526,133
        
        
        8,143,733Equity:Share capital
        9
        
        69,705,389
        
        
        66,062,961Additional paid-in capital
        
        
        12,362,281
        
        
        10,445,524Deficit
        
        
        (89,912,383
        )
        
        (82,106,044
        )Total equity attributable to the equity holders of the Corporation
        
        
        (7,844,713
        )
        
        (5,597,559
        )Non-controlling interest
        8
        
        400,000
        
        
        400,000Total equity
        
        
        (7,444,713
        )
        
        (5,197,559
        )Commitments and contingencies
        10Total liabilities and equity
        
        $
        1,754,179
        
        $
        6,375,266
 See accompanying notes to consolidated financial statements. On behalf of the Board: /s/ Paul Averback
        Director/s/ Paul McDonald
        Director
 49
    NYMOX PHARMACEUTICAL CORPORATIONConsolidated Statements of Operations and Comprehensive LossYears ended December 31, 2012, 2011 and 2010(In US dollars)
  Note
        
        2012
        
        
        2011
        
        
        2010Revenues:Sales of goods
        
        $
        454,987
        
        $
        496,215
        
        $
        582,383Licensing Revenues:Upfront payment
        7
        
        2,617,600
        
        
        2,617,600
        
        
        109,0673,072,587
        
        
        3,113,815
        
        
        691,450Expenses:Research and development
        9(c)
        
        8,572,528
        
        
        9,461,081
        
        
        5,116,227Less research tax credits
        12(a)
        
        (289,766
        )
        
        (486,910
        )
        
        (236,101
        )8,282,762
        
        
        8,974,171
        
        
        4,880,126General and administrative
        9(c)
        
        1,972,120
        
        
        2,832,870
        
        
        1,847,122Marketing
        9(c)
        
        158,431
        
        
        642,235
        
        
        152,389Cost of sales
        11
        
        253,925
        
        
        289,866
        
        
        316,94510,667,238
        
        
        12,739,142
        
        
        7,196,582Results from operating activities
        
        
        (7,594,651
        )
        
        (9,625,327
        )
        
        (6,505,132
        )Net finance income (costs):Finance income
        16(b)
        
        6,180
        
        
        12,817
        
        
        1,191Finance costs
        16(b)
        
        (39,118
        )
        
        (39,879
        )
        
        (32,372
        )(32,938
        )
        
        (27,062
        )
        
        (31,181
        )Net loss and comprehensive loss attributable to the equity holders of the Corporation
        
        $
        (7,627,589
        )
        $
        (9,652,389
        )
        $
        (6,536,313
        )Basic and diluted loss per share
        13
        $
        (0.23
        )
        $
        (0.30
        )
        $
        (0.20
        )Weighted average number of common shares outstanding
        13
        
        33,176,185
        
        
        32,711,431
        
        
        31,940,584
 See accompanying notes to consolidated financial statements. 50
    NYMOX PHARMACEUTICAL CORPORATIONConsolidated Statements of Changes in EquityYears ended December 31, 2012, 2011 and 2010(In US dollars)
  Attributable to equity holders of the CorporationAdditional
        
        
        
        
        
        
        
        
        Non-Share capital
        
        paid-in
        
        
        
        
        
        
        
        
        controlling
        
        TotalNote
        Number
        
        Dollars
        
        capital
        
        
        Deficit
        
        
        Total
        
        
        interest
        
        equityBalance, December 31, 2011
        
        32,993,302
        $
        66,062,961
        $
        10,445,524
        
        $
        (82,106,044
        )
        $
        (5,597,559
        )
        $
        400,000
        $
        (5,197,559
        )Transactions with owners, recorded directly in equity:Issuance of share capital
        9(a)
        558,620
        
        3,575,000
        
        –
        
        
        –
        
        
        3,575,000
        
        
        –
        
        3,575,000Exercise of stock options and option surrender agreementsCash
        9(b)
        20,520
        
        22,100
        
        –
        
        
        –
        
        
        22,100
        
        
        –
        
        22,100Ascribed value
        
        –
        
        45,328
        
        (45,328
        )
        
        –
        
        
        –
        
        
        –
        
        –Share issue costs
        
        –
        
        –
        
        –
        
        
        (178,750
        )
        
        (178,750
        )
        
        –
        
        (178,750
        )Stock-based compensation
        9(c)
        –
        
        –
        
        1,962,085
        
        
        –
        
        
        1,962,085
        
        
        –
        
        1,962,085Total contributions by owners
        
        579,140
        
        3,642,428
        
        1,916,757
        
        
        (178,750
        )
        
        5,380,435
        
        
        –
        
        5,380,435Net loss and comprehensive loss
        
        –
        
        –
        
        –
        
        
        (7,627,589
        )
        
        (7,627,589
        )
        
        –
        
        (7,627,589
        )Balance, December 31, 2012
        
        33,572,442
        $
        69,705,389
        $
        12,362,281
        
        $
        (89,912,383
        )
        $
        (7,844,713
        )
        $
        400,000
        $
        (7,444,713
        )Balance, December 31, 2010
        
        32,573,856
        $
        62,855,147
        $
        6,493,544
        
        $
        (72,203,305
        )
        $
        (2,854,614
        )
        $
        400,000
        $
        (2,454,614
        )Transactions with owners, recorded directly in equity:Issuance of share capital
        9(a)
        353,407
        
        3,000,000
        
        –
        
        
        –
        
        
        3,000,000
        
        
        –
        
        3,000,000Exercise of stock options and option surrender agreementsCash
        9(b)
        66,039
        
        54,040
        
        –
        
        
        –
        
        
        54,040
        
        
        –
        
        54,040Ascribed value
        
        –
        
        153,774
        
        (53,424
        )
        
        (100,350
        )
        
        –
        
        
        –
        
        –Share issue costs
        
        –
        
        –
        
        –
        
        
        (150,000
        )
        
        (150,000
        )
        
        –
        
        (150,000
        )Stock-based compensation
        9(c)
        –
        
        –
        
        4,005,404
        
        
        –
        
        
        4,005,404
        
        
        –
        
        4,005,404Total contributions by owners
        
        419,446
        
        3,207,814
        
        3,951,980
        
        
        (250,350
        )
        
        6,909,444
        
        
        –
        
        6,909,444Net loss and comprehensive loss
        
        –
        
        –
        
        –
        
        
        (9,652,389
        )
        
        (9,652,389
        )
        
        –
        
        (9,652,389
        )Balance, December 31, 2011
        
        32,993,302
        $
        66,062,961
        $
        10,445,524
        
        $
        (82,106,044
        )
        $
        (5,597,559
        )
        $
        400,000
        $
        (5,197,559
        )Balance, January 1, 2010
        
        31,283,778
        $
        57,955,147
        $
        6,014,679
        
        $
        (65,421,992
        )
        $
        (1,452,166
        )
        $
        400,000
        $
        (1,052,166
        )Transactions with owners, recorded directly in equity:Issuance of share capital
        9(a)
        1,290,078
        
        4,900,000
        
        –
        
        
        –
        
        
        4,900,000
        
        
        –
        
        4,900,000Share issue costs
        
        –
        
        –
        
        –
        
        
        (245,000
        )
        
        (245,000
        )
        
        –
        
        (245,000
        )Stock-based compensation
        9(c)
        –
        
        –
        
        478,865
        
        
        –
        
        
        478,865
        
        
        –
        
        478,865Total contributions by owners
        
        1,290,078
        
        4,900,000
        
        478,865
        
        
        (245,000
        )
        
        5,133,865
        
        
        –
        
        5,133,865Net loss and comprehensive loss
        
        –
        
        –
        
        –
        
        
        (6,536,313
        )
        
        (6,536,313
        )
        
        –
        
        (6,536,313
        )Balance, December 31, 2010
        
        32,573,856
        $
        62,855,147
        $
        6,493,544
        
        $
        (72,203,305
        )
        $
        (2,854,614
        )
        $
        400,000
        $
        (2,454,614
        )
 See accompanying notes to consolidated financial statements. 51
    NYMOX PHARMACEUTICAL CORPORATIONConsolidated Statements of Cash FlowsAs of December 31, 2012 and 2011, and for each of the years in the three-year period endedDecember 31, 2012(In US dollars)
  Note
        2012
        
        
        2011
        
        
        2010Cash flows from (used in) operating activities:Net loss
        $
        (7,627,589
        )
        $
        (9,652,389
        )
        $
        (6,536,313
        )Adjustments for:Depreciation of property and equipment
        5
        10,413
        
        
        14,716
        
        
        10,223Stock-based compensation
        9(c)
        1,962,085
        
        
        4,005,404
        
        
        478,865Amortization of lease inducement
        
        -
        
        
        -
        
        
        (12,646
        )Changes in non-cash operating balances:Prepaid expenses
        
        (31,988
        )
        
        -
        
        
        -Trade accounts receivable and other receivables
        
        65,837
        
        
        (109,190
        )
        
        49,463Research tax credits receivable
        
        (289,767
        )
        
        (6,330
        )
        
        15,057Inventories
        
        (18,883
        )
        
        (6,172
        )
        
        18,966Long-term security deposit
        
        -
        
        
        -
        
        
        9,598Trade accounts payable and accrued liabilities
        
        243,667
        
        
        (1,766,411
        )
        
        847,952Deferred revenue
        
        (2,617,600
        )
        
        (2,617,600
        )
        
        12,978,933(8,303,825
        )
        
        (10,137,972
        )
        
        7,860,098Cash flows from (used in) financing activities:Proceeds from issuance of share capital
        9(a)
        3,575,000
        
        
        3,000,000
        
        
        4,900,000Share issue costs
        
        (178,750
        )
        
        (150,000
        )
        
        (245,000
        )Proceeds from exercise of stock options
        
        22,100
        
        
        54,040
        
        
        -3,418,350
        
        
        2,904,040
        
        
        4,655,000Cash flows used in investing activities:Additions to property and equipment
        
        (3,371
        )
        
        (22,146
        )
        
        (8,801
        )Net (decrease) increase in cash
        
        (4,888,846
        )
        
        (7,256,078
        )
        
        12,506,297Cash, beginning of year
        
        5,918,921
        
        
        13,174,999
        
        
        668,702Cash, end of year
        $
        1,030,075
        
        $
        5,918,921
        
        $
        13,174,999
 See accompanying notes to consolidated financial statements. 52
    NYMOX PHARMACEUTICAL CORPORATIONNotes to Consolidated Financial StatementsAs of December 31, 2012 and 2011, and for each of the years in the three-year period endedDecember 31, 2012(In US dollars)
  1.
      Business activities: Nymox Pharmaceutical Corporation is a company domiciled in Canada and is incorporated under the Canada Business Corporations Act. Nymox Pharmaceutical Corporation including its subsidiaries, Nymox Corporation, a Delaware Corporation, and Serex Inc. of New Jersey (together referred to as the “Corporation”), is a biopharmaceutical corporation, which specializes in the research and development of products for the aging population. The head-office of the Corporation is located at 9900 Cavendish Boulevard, Saint Laurent, Québec. The Corporation developed AlzheimAlertTM, a urinary test that aids physicians in the diagnosis of Alzheimer’s disease. The Corporation currently markets NicAlertTMand TobacAlertTM, tests that use urine or saliva to detect use of tobacco products. The Corporation is developing NX-1207, a novel treatment for benign prostatic hyperplasia which is in Phase 3 clinical trials. The Corporation is also developing therapeutics for the treatment of Alzheimer’s disease and new antibacterial agents for the treatment of bacterial infections in humans, including a treatment for E-coli O157:H7 bacterial contamination in meat and other food and drink products. Since 1989, the Corporation’s activities and resources have been primarily focused on developing certain pharmaceutical technologies. The Corporation is subject to a number of risks, including the successful development and marketing of its technologies and maintaining access to existing financing arrangements under the Common Stock Private Purchase Agreement referred to in note 9 (a). The Corporation depends on this financing, as well as collaboration agreements, to fund its operations. In order to achieve its business plan and the realization of its assets and liabilities in the normal course of operations, the Corporation anticipates the need to raise additional capital and/or achieve sales and other revenue-generating activities. Management believes that cash balances, funds from operations, as well as funds from the common stock private purchase agreement will be sufficient to meet the Corporation's requirements for the next year. The Corporation is listed on the NASDAQ Stock Market. 2.
      Basis of preparation: (a)
      Statement of compliance: The consolidated financial statements of the Corporation have been prepared in accordance with International Financial Reporting Standards (“IFRS”) and its interpretations as issued by the International Accounting Standards Board (“IASB”). 53
    NYMOX PHARMACEUTICAL CORPORATIONNotes to Consolidated Financial Statements, ContinuedAs of December 31, 2012 and 2011, and for each of the years in the three-year period endedDecember 31, 2012(In US dollars)
  2.
      Basis of preparation (continued): (a)
      Statement of compliance (continued): The consolidated financial statements were authorized for issue by the Board of Directors on March 1, 2013. (b)
      Basis of measurement: The consolidated financial statements have been prepared on a going concern and on the historical cost basis. (c)
      Functional and presentation currency: These consolidated financial statements are presented in United States dollars, which is the Corporation and its subsidiaries’ functional currency. (d)
      Use of estimates and judgments: The preparation of the consolidated financial statements in conformity with IFRS requires management to make estimates and assumptions that affect the reported amounts of assets, liabilities, income and expenses. Information about critical judgments in applying accounting policies and assumption and estimation uncertainties that have the most significant effect on the amounts recognized in the consolidated financial statements is noted below: (i)
      Judgments in applying accounting policies Licensing revenues and deferred revenue: Revenue recognition is subject to critical judgments, particularly in collaboration agreements that include multiple deliverables, as judgment is required in allocating revenue to each component, including upfront payments, milestone payments, sale of goods, royalties and license fees. Management uses judgment in estimating the service period over which revenue is recognized (note 7). (ii)
      Estimation uncertainties Stock options: There is estimation uncertainty with respect to selecting inputs to the Black-Scholes pricing model used to determine the fair value of the stock options (note 9 (c)). Other areas of judgment and uncertainty relate to the recoverability of research tax credits and deferred tax assets. Reported amounts and note disclosure reflect the overall economic conditions that are most likely to occur and anticipated measures management intends to take. Actual results could differ from those estimates. The above estimates and assumptions are reviewed regularly. Revisions to accounting estimates are recognized in the period in which the estimates are revised and in any future periods affected. 54
    NYMOX PHARMACEUTICAL CORPORATIONNotes to Consolidated Financial Statements, ContinuedAs of December 31, 2012 and 2011, and for each of the years in the three-year period endedDecember 31, 2012(In US dollars)
  3.
      Significant accounting policies: The accounting policies set out below have been applied consistently to all periods presented in these consolidated financial statements. Refer to note 4 which addresses standards issued but not yet effective. (a)
      Consolidation: The consolidated financial statements of the Corporation have been prepared in accordance with IFRS and include the accounts of its subsidiaries. Subsidiaries are entities controlled by the Corporation. The financial statements of subsidiaries are included in the consolidated financial statements from the date that control commences until the date that control ceases. Intercompany balances and transactions have been eliminated on consolidation. (b)
      Financial instruments: Financial instruments are classified into one of the following five categories: held-for-trading, held-to-maturity investments, loans and receivables, available-for-sale financial assets or other financial liabilities. All financial instruments, including derivatives, are included in the consolidated statements of financial position and are measured at fair value, with the exception of loans and receivables, held-to-maturity investments and other financial liabilities, which are measured at amortized cost. The Corporation has classified its cash, trade accounts receivable and other receivables as “loans and receivables”, and its trade accounts payable, accrued liabilities and redeemable preferred shares as “other financial liabilities”. The redeemable preferred shares are recorded at their redemption amount (see note 8). The Corporation must classify the fair value measurements of financial instruments according to a three-level hierarchy, based on the type of inputs used in making these measurements. These tiers include: Level 1, defined as observable inputs such as quoted prices in active markets; Level 2, defined as inputs other than quoted prices in active markets that are either directly or indirectly observable; and Level 3, defined as unobservable inputs in which little or no market data exists, therefore requiring an entity to develop its own assumptions. As at December 31, 2012 and 2011, the Corporation held no assets or liabilities required to be measured at fair value. (i)
      Financial assets: The Corporation initially recognizes loans and receivables on the date that they are originated. Loans and receivables are financial assets with fixed or determinable payments that are not quoted in an active market. Such assets are recognized initially at fair value plus any directly attributable transaction costs. Subsequent to initial recognition, loans and receivables are measured at amortized cost using the effective interest method, less any impairment losses. The Corporation derecognizes a financial asset when the contractual rights to the cash flows from the asset expire, or it transfers the rights to receive the contractual cash flows on the financial asset in a transaction in which substantially all the risks and rewards of ownership of the financial asset are transferred. 55
    NYMOX PHARMACEUTICAL CORPORATIONNotes to Consolidated Financial Statements, ContinuedAs of December 31, 2012 and 2011, and for each of the years in the three-year period endedDecember 31, 2012(In US dollars)
  3.
      Significant accounting policies (continued): (b)
      Financial instruments (continued): (i)
      Financial assets (continued): Financial assets and liabilities are offset and the net amount presented in the consolidated statements of financial position when, and only when, the Corporation has a legal right to offset the amounts and intends either to settle on a net basis or to realize the asset and settle the liability simultaneously. (ii)
      Financial liabilities: The Corporation initially recognizes other financial liabilities on the trade date at which the Corporation becomes a party to the contractual provisions of the instrument. Other financial liabilities are recognized initially at fair value plus any directly attributable transaction costs. Subsequent to initial recognition, these financial liabilities are measured at amortized cost using the effective interest method. The Corporation derecognizes a financial liability when its contractual obligations are discharged, cancelled or expired. Interest, losses and gains relating to a financial liability are recognized in the statement of operations and comprehensive loss. (iii)
      Share capital: Common shares are classified as equity. Incremental costs attributable to the issuance of common shares are recognized as an increase to deficit. (c)
      Inventories: Inventories consist of finished goods and are carried at the lower of first-in, first-out cost and net realizable value. Net realizable value is the estimated selling price in the ordinary course of business, less selling expenses. (d)
      Property and equipment: (i)
      Recognition and measurement: Property and equipment are measured at cost, less accumulated depreciation and accumulated impairment losses. Cost includes expenditure that is directly attributable to the acquisition of the asset. Purchased software that is integral to the functionality of the related equipment is capitalized as part of that equipment. When parts of an item of property and equipment have significantly different useful lives, they are accounted for as separate items (major components) of property and equipment. Gains and losses on disposal of an item of property and equipment are recognized as the difference in the proceeds from disposal and the carrying amount of property and equipment. 56
    NYMOX PHARMACEUTICAL CORPORATIONNotes to Consolidated Financial Statements, ContinuedAs of December 31, 2012 and 2011, and for each of the years in the three-year period endedDecember 31, 2012(In US dollars)
  3.
      Significant accounting policies (continued): (d)
      Property and equipment (continued): (ii)
      Subsequent costs: The cost of replacing a part of an item of property and equipment is recognized in the carrying amount of the item if it is probable that the future economic benefits embodied within the part will flow to the Corporation, and its cost can be measured reliably. The carrying amount of the replaced part is derecognized. The costs of the day-to-day servicing of property and equipment are recognized in the statement of operations and comprehensive loss. (iii)
      Depreciation: Depreciation is calculated on the depreciable amount, which is the cost of an asset less its residual value. Depreciation is recognized on a straight-line basis over the estimated useful lives of each component of an item of property and equipment, since this most closely reflects the expected pattern of consumption of the future economic benefits embodied in the asset. The estimated useful lives for the current and comparative periods are represented by the following estimated useful lives: Asset
        Useful lifeLaboratory equipment
        5 yearsComputer equipment
        3 yearsOffice equipment and fixtures
        5 years
 Depreciation methods, useful lives and residual values are reviewed on an ongoing basis and adjusted if appropriate. (e)
      Intangible assets: (i)
      Intellectual property rights: Intellectual property rights that are acquired by the Corporation and have finite useful lives are measured at cost less accumulated amortization and accumulated impairment losses. 57
    NYMOX PHARMACEUTICAL CORPORATIONNotes to Consolidated Financial Statements, ContinuedAs of December 31, 2012 and 2011, and for each of the years in the three-year period endedDecember 31, 2012(In US dollars)
  3.
      Significant accounting policies (continued): (e)
      Intangible assets (continued): (ii)
      Research and development expenditures: Expenditure on research activities, net of research tax credits, undertaken with the prospect of gaining new scientific or technical knowledge and understanding, is recognized in comprehensive loss as incurred. Development activities, net of research tax credits, involve a plan or design for the production of new or substantially improved products and processes. Development expenditure is capitalized only if development costs can be measured reliably, the product or process is technically and commercially feasible, future economic benefits are probable, and the Corporation intends to and has sufficient resources to complete development and to use or sell the asset. Other development expenditure is recognized in research and development expenses as incurred. At December 31, 2012 and December 31, 2011 no development expenditures have been capitalized. (iii)
      Amortization: Amortization is calculated on the cost of the asset, less its residual value. Amortization methods, useful lives and residual values are reviewed on an ongoing basis and adjusted if appropriate. (f)
      Impairment: (i)
      Financial assets: Financial assets are assessed at each reporting date to determine whether there is objective evidence that they are impaired. A financial asset is impaired if objective evidence indicates that a loss event has occurred after the initial recognition of the asset, and that the loss event had a negative effect on the estimated future cash flows of that asset that can be estimated reliably. Objective evidence that financial assets are impaired can include default or delinquency by a debtor, restructuring of an amount due to the Corporation on terms that the Corporation would not consider otherwise, and indications that a debtor or issuer will enter bankruptcy. In assessing impairment, the Corporation uses historical trends of the probability of default, timing of recoveries and the amount of loss incurred, adjusted for management’s judgment as to whether current economic and credit conditions are such that the actual losses are likely to be greater or less than suggested by historical trends. 58
    NYMOX PHARMACEUTICAL CORPORATIONNotes to Consolidated Financial Statements, ContinuedAs of December 31, 2012 and 2011, and for each of the years in the three-year period endedDecember 31, 2012(In US dollars)
  3.
      Significant accounting policies (continued): (f)
      Impairment (continued): (i)
      Financial assets (continued): An impairment loss in respect of a financial asset measured at amortized cost is calculated and recognized for the amount by which the asset's carrying amount exceeds the present value of the estimated future cash flows discounted at the asset’s original effective interest rate. Losses are reflected in an allowance account against receivables. When a subsequent event causes the amount of impairment loss to decrease, the decrease in impairment loss is reversed. (ii)
      Non-financial assets: The carrying amounts of the Corporation’s non-financial assets, including property and equipment, are reviewed at each reporting date to determine whether there is any indication of impairment. If any such indication exists, then the asset’s recoverable amount is estimated. The recoverable amount of an asset or cash-generating unit is the greater of its value in use and its fair value less costs to sell. In assessing value in use, the estimated future cash flows are discounted to their present value using a pre-tax discount rate that reflects current market assessments of the time value of money and the risks specific to the asset. For the purpose of impairment testing, assets that cannot be tested individually are grouped together into the smallest group of assets that generates cash inflows from continuing use that are largely independent of the cash inflows of other assets or groups of assets (the “cash-generating unit, or CGU”). The Corporation’s corporate assets do not generate separate cash inflows. If there is an indication that a corporate asset may be impaired, then the recoverable amount is determined for the CGU to which the corporate asset belongs. An impairment loss is recognized if the carrying amount of an asset or its CGU exceeds its estimated recoverable amount. Impairment losses recognized in respect of CGUs are allocated to reduce the carrying amounts of the assets in the CGU on a pro rata basis. Impairment losses recognized in prior periods are assessed at each reporting date for any indications that the loss has decreased or no longer exists. An impairment loss is reversed if there has been a change in the estimates used to determine the recoverable amount. An impairment loss is reversed only to the extent that the asset’s carrying amount does not exceed the carrying amount that would have been determined, net of depreciation or amortization, if no impairment loss had been recognized. 59
    NYMOX PHARMACEUTICAL CORPORATIONNotes to Consolidated Financial Statements, ContinuedAs of December 31, 2012 and 2011, and for each of the years in the three-year period endedDecember 31, 2012(In US dollars)
  3.
      Significant accounting policies (continued): (g)
      Revenue recognition: Revenue from product sales is recognized when the product has been delivered and obligations as defined in the agreement are performed. Collaboration agreements that include multiple deliverables are considered to be multiple-element arrangements. Under this type of arrangement, the identification of separate units of accounting is required and revenue is allocated among the separate units based on their relative fair values. Payments received under a collaboration agreement may include upfront payments, milestone payments, sale of goods, royalties and license fees. Revenue for each unit of accounting is recorded as described below: (i)
      Upfront payments: Upfront payments are deferred and recognized as revenue on a systematic basis over the estimated service period. Changes in estimates are recognized prospectively when changes to the expected term are determined. (ii)
      Milestone payments: Revenue subject to the achievement of milestones is recognized only when the specified events have occurred and collectability is reasonably assured. Specifically, the criteria for recognizing milestone payments are that (i) the milestone is substantive in nature, (ii) the achievement was not reasonably assured at the inception of the agreement, and (iii) the Corporation has no further involvement or obligation to perform associated with the achievement of the milestone, as defined in the related collaboration arrangement. (iii)
      Sale of goods: Revenue from the sale of goods is recognized when the Corporation has transferred to the buyer the significant risks and rewards of ownership of the goods, there is no continuing management involvement with the goods, and the amount of revenue can be measured reliably. (iv)
      Royalties and license fees: Royalties and license fees are recognized when conditions and events under the license agreement have occurred and collectability is reasonably assured. 60
    NYMOX PHARMACEUTICAL CORPORATIONNotes to Consolidated Financial Statements, ContinuedAs of December 31, 2012 and 2011, and for each of the years in the three-year period endedDecember 31, 2012(In US dollars)
  3.
      Significant accounting policies (continued): (h)
      Foreign currency: Monetary assets and liabilities of the Corporation’s Canadian and US subsidiaries denominated in currencies other than the US dollar are translated at the rates of exchange at the reporting date. Non-monetary items that are measured in terms of historical cost in a foreign currency are translated using the exchange rate at the date of the transaction. Income and expenses denominated in foreign currencies are translated at the average rate prevailing during the year. Foreign exchange loss and gain are reported on a net basis, within finance costs or finance income. (i)
      Research tax credits and grants: The Corporation is entitled to scientific research and experimental development tax credits (“research tax credits”) granted by the Canadian federal government and the government of the province of Québec. Federal research tax credits, which are non-refundable, are earned on qualified research and development expenditures and can only be used to offset federal income taxes otherwise payable. Provincial research tax credits, which are refundable, are earned on qualified research and development expenditures incurred in the province of Québec. The Corporation is also entitled to a grant from the U.S. Government under the Qualifying Therapeutic Discovery Project for its ongoing Phase III clinical trial program for NX-1207 for the treatment of benign prostatic hyperplasia of which, in April 2011, the Corporation received its full entitlement under this program. These research tax credits and grants are recognized as a reduction of research and development expenditures in the period in which they become receivable, provided that there is reasonable assurance that they will be received. (j)
      Stock-based compensation: The grant date fair value of stock-based compensation awards granted to employees and directors is recognized as an expense, with a corresponding increase in equity, over the period that the employees or directors unconditionally become entitled to the awards. The amount recognized as an expense is adjusted to reflect the number of awards for which the related service vesting conditions are expected to be met, such that the amount ultimately recognized as an expense is based on the number of awards that do meet the related service at the vesting date. 61
    NYMOX PHARMACEUTICAL CORPORATIONNotes to Consolidated Financial Statements, ContinuedAs of December 31, 2012 and 2011, and for each of the years in the three-year period endedDecember 31, 2012(In US dollars)
  3.
      Significant accounting policies (continued): (k)
      Employee benefits: Short-term employee benefits: Short-term employee benefits obligations are measured on an undiscounted basis and are expensed as the related service is provided. In addition to their salaries, employees of the Corporation are covered by a benefit package which includes a health plan, dental plan, disability insurance and life insurance coverage. Participation in this plan is paid by the Corporation in full. Any employee that elects to extend the coverage to members of their family must pay the additional premium. (l)
      Lease payments: Payments made under operating leases are recognized on a straight-line basis over the term of the lease. Lease incentives received are recognized as an integral part of the total lease expense, over the term of the lease. (m)
      Income taxes: Income tax expense comprises current and deferred taxes. Current tax and deferred tax are recognized in the statement of operations and comprehensive loss except to the extent that it relates to a business combination, or items recognized directly in equity or in other comprehensive loss. Current tax is the expected tax payable or receivable on the taxable income or loss of the year, using tax rates enacted or substantively enacted at the reporting date, and any adjustment to tax payable in respect of previous years. Deferred tax is recognized in respect of temporary differences between the carrying amounts of assets and liabilities for financial reporting purposes and the amounts used for taxation purposes. Deferred tax is not recognized for the following temporary differences: the initial recognition of assets or liabilities in a transaction that is not a business combination and that affects neither accounting nor taxable profit or loss and differences relating to investments in subsidiaries to the extent that it is probable that they will not reverse in the foreseeable future. Deferred tax is measured at the tax rates that are expected to be applied to temporary differences when they reverse, based on the laws that have been enacted or substantively enacted by the reporting date. Deferred tax assets and liabilities are offset if there is a legally enforceable right to offset current tax liabilities and assets, and they relate to income taxes levied by the same tax authority on the same taxable entity, or on different tax entities, but they intend to settle current tax liabilities and assets on a net basis or their tax assets and liabilities will be realized simultaneously. A deferred tax asset is recognized for unused tax losses and deductible temporary differences, to the extent that it is probable that future taxable profits will be available against which they can be utilized. Deferred tax assets are reviewed at each reporting date and are reduced to the extent that it is no longer probable that the related tax benefit will be realized. 62
    NYMOX PHARMACEUTICAL CORPORATIONNotes to Consolidated Financial Statements, ContinuedAs of December 31, 2012 and 2011, and for each of the years in the three-year period endedDecember 31, 2012(In US dollars)
  3.
      Significant accounting policies (continued): (n)
      Earnings per share: Basic earnings per share are determined using the weighted average number of common shares outstanding during the period. Diluted earnings per share are computed in a manner consistent with basic earnings per share, except that the weighted average shares outstanding are increased to include additional shares from the assumed exercise of options and warrants, if dilutive. The number of additional shares is calculated by assuming that outstanding options were exercised, and that the proceeds from such exercises as well as the assumed proceeds from future services were used to acquire shares of common stock at the average market price during the reporting period. (o)
      Determination of fair values: Certain of the Corporation’s accounting policies and disclosures require the determination of fair value, for both financial and non-financial assets and liabilities. Fair values of stock options granted have been determined for measurement purposes based on the following method. When applicable, further information about the assumptions made in determining fair values is disclosed in the related notes. Stock-based compensation: The fair value of the stock options is measured using the Black-Scholes pricing model. Measurement inputs include share price on measurement date, exercise price of the instrument, expected volatility (based on weighted average historic volatility), weighted average expected life of the instruments (based on historical experience and general option holder behavior), expected dividends, and the risk-free interest rate (based on government bonds). Service conditions attached to the transactions are not taken into account in determining fair value. (p)
      Segment reporting: An operating segment is a component of the Corporation that engages in business activities from which it may earn revenues and incur expenses, including revenues and expenses that relate to transactions with any of the Corporation’s other components. Operating results of all operating segments are reviewed regularly by the Corporation’s Chief Executive Officer, who is the Corporation’s chief operating decision maker, who makes decisions about resources to be allocated to the segment and assesses its performance, and for which discrete financial information is available. 4.
      Changes in accounting policies: New standards and interpretations issued but not yet adopted: A number of new standards, interpretations and amendments to existing standards were issued by the IASB or International Financial Reporting Interpretations Committee (“IFRIC”). They are mandatory but not yet effective for the year ended December 31, 2012, and have not been applied in preparing these consolidated financial statements. Many of these are not applicable or are inconsequential to the Corporation and have been excluded from the discussion below. The following standards and interpretations have been issued by the IASB and the IFRIC and the Corporation is currently assessing their impact on the financial statements: 63
    NYMOX PHARMACEUTICAL CORPORATIONNotes to Consolidated Financial Statements, ContinuedAs of December 31, 2012 and 2011, and for each of the years in the three-year period endedDecember 31, 2012(In US dollars)
  4.
      Changes in accounting policies (continued): New standards and interpretations issued but not yet adopted (continued): IFRS 9 -Financial Instruments(“IFRS 9”)ultimately replaces IAS 39 - Financial Instruments: Recognition and Measurement(“IAS 39”). The replacement of IAS 39 is a three-phase project with the objective of improving and simplifying the reporting for financial instruments. The issuance of the first phase of the IFRS 9 provides guidance on the classification and measurement of financial assets and financial liabilities. IFRS 9 establishes two measurement categories for financial assets: amortized cost and fair value. Existing IAS 39 categories of loans and receivables, held-to-maturity investments, and available-for-sale financial assets have been eliminated. The criteria for a financial asset to be measured at amortized cost include: the objective of the business model is to hold assets in order to collect contractual cash flows; and, the contractual terms give rise, on contractual dates, to cash flows that are solely payments of principal and interest on principal outstanding. All other financial assets are measured at fair value. The Company intends to adopt IFRS 9 in its consolidated financial statements for the annual period beginning on January 1, 2015. The Company has not yet assessed the impact of the adoption of this standard on its consolidated financial statements, however does not expect that it will have a significant impact. IFRS 10 -Consolidated Financial Statements(”IFRS 10”)replaces SIC-12, Consolidation - Special Purpose Entities, and parts of IAS 27, Consolidated and Separate Financial Statements. The new standard builds on existing principles by identifying the concept of control as the determining factor in whether an entity should be included in a company’s consolidated financial statements. The standard provides additional guidance to assist in the determination of control where it is difficult to assess. The Company intends to adopt IFRS 10, including the amendments issued in June 2012, in its consolidated financial statements for the annual period beginning on January 1, 2013. The Company does not expect IFRS 10 to have a significant impact on the consolidated financial statements. IFRS 12 -Disclosure of Interests in Other Entities(“IFRS 12”)contains the disclosure requirements for entities that have interests in subsidiaries, joint arrangements (i.e. joint operations or joint ventures), associates and/or unconsolidated structured entities, aiming to provide information to enable users to evaluate: the nature of, and risks associated with, an entity's interests in other entities; andthe effects of those interests on the entity's financial position, financial performance and cash flows. The Company intends to adopt IFRS 12, including the amendments issued in June 2012, in its consolidated financial statements for the annual period beginning on January 1, 2013. The Company does not expect IFRS 12 to have a significant impact on the consolidated financial statements, because of the nature of the Company’s interests in other entities. 64
    NYMOX PHARMACEUTICAL CORPORATIONNotes to Consolidated Financial Statements, ContinuedAs of December 31, 2012 and 2011, and for each of the years in the three-year period endedDecember 31, 2012(In US dollars)
  4.
      Changes in accounting policies (continued): New standards and interpretations issued but not yet adopted (continued): IFRS 13 -Fair Value Measurement(“IFRS 13”)provides new guidance on fair value measurement and disclosure requirements. IFRS 13 replaces the fair value measurement guidance contained in individual IFRS with a single source of fair value measurement guidance. It defines fair value, establishes a framework for measuring fair value and sets out disclosure requirements for fair value measurements. It explains how to measure fair value when it is required or permitted by other IFRS. It does not introduce new requirements to measure assets or liabilities at fair value, nor does it eliminate the practicability exceptions to fair value measurements that currently exist in certain standards. The Company intends to adopt IFRS 13 prospectively in its consolidated financial statements for the annual period beginning on January 1, 2013. The Company does not expect IFRS 13 to have a significant impact on the consolidated financial statements. 65
    NYMOX PHARMACEUTICAL CORPORATIONNotes to Consolidated Financial Statements, ContinuedAs of December 31, 2012 and 2011, and for each of the years in the three-year period endedDecember 31, 2012(In US dollars)
  5.
      Property and equipment: OfficeequipmentLaboratory
        
        
        Computer
        
        
        andequipment
        
        
        equipment
        
        
        fixtures
        
        
        TotalCost:Balance at December 31, 2010
        $
        433,201
        
        $
        22,597
        
        $
        92,767
        
        $
        548,565Additions
        
        2,907
        
        
        9,651
        
        
        9,588
        
        
        22,146Disposals
        
        –
        
        
        (1,600
        )
        
        (429
        )
        
        (2,029
        )Balance at December 31, 2011
        $
        436,108
        
        $
        30,648
        
        $
        101,926
        
        $
        568,682Balance at December 31, 2011
        $
        436,108
        
        $
        30,648
        
        $
        101,926
        
        $
        568,682Additions
        
        3,003
        
        
        368
        
        
        –
        
        
        3,371Disposals
        
        (20,684
        )
        
        (1,790
        )
        
        (690
        )
        
        (23,164
        )Balance at December 31, 2012
        $
        418,427
        
        $
        29,226
        
        $
        101,236
        
        $
        548,889Accumulated depreciation:Balance at December 31, 2010
        $
        428,008
        
        $
        16,599
        
        $
        89,228
        
        $
        533,835Depreciation for the year
        
        5,521
        
        
        6,018
        
        
        3,177
        
        
        14,716Disposals
        
        –
        
        
        (1,600
        )
        
        (429
        )
        
        (2,029
        )Balance at December 31, 2011
        $
        433,529
        
        $
        21,017
        
        $
        91,976
        
        $
        546,522Balance at December 31, 2011
        $
        433,529
        
        $
        21,017
        
        $
        91,976
        
        $
        546,522Depreciation for the year
        
        1,717
        
        
        5,518
        
        
        3,178
        
        
        10,413Disposals
        
        (20,684
        )
        
        (1,790
        )
        
        (690
        )
        
        (23,164
        )Balance at December 31, 2012
        $
        414,562
        
        $
        24,745
        
        $
        94,464
        
        $
        533,771Carrying amounts:At December 31, 2010
        $
        5,193
        
        $
        5,998
        
        $
        3,539
        
        $
        14,730At December 31, 2011
        
        2,579
        
        
        9,631
        
        
        9,950
        
        
        22,160At December 31, 2012
        
        3,865
        
        
        4,481
        
        
        6,772
        
        
        15,118
 The depreciation expense of property and equipment is included in research and development in the statements of operations and comprehensive loss. 6.
      Intangible assets: The intellectual property rights, having a cost of $2,222,661 and an accumulated amortization of $2,222,661 at December 31, 2011 and 2012, are still property of the Corporation. 66
    NYMOX PHARMACEUTICAL CORPORATIONNotes to Consolidated Financial Statements, ContinuedAs of December 31, 2012 and 2011, and for each of the years in the three-year period endedDecember 31, 2012(In US dollars)
  7.
      Licensing revenues and deferred revenue: On December 16, 2010, the Corporation signed a license and collaboration agreement with Recordati Ireland Ltd. (“Recordati”), a European pharmaceutical group, for the development and commercialization of NX-1207 in Europe, including Russia and the CIS, the Middle East, the Maghreb area of North Africa and South Africa. The license and collaboration agreement covers the use of NX-1207 for the treatment of benign prostatic hyperplasia (“BPH”) as the initial indication for development and commercialization. Recordati made an upfront payment to the Corporation of €10 million (US$13,088,000), in December 2010. The agreement provides for further payments to be made upon regulatory approval and sales milestones payments, and tiered supply and royalty payments of a minimum of 26% to increase progressively up to 40% of total net sales in the case specific contractual conditions are achieved. The upfront payment of $13,088,000 has been deferred and is being recognized as revenue on a systematic basis over the estimated service period of five years, of which approximately three years remain at December 31, 2012. This period may be modified in the future based on additional information that may be received by the Corporation. In 2012, an amount of $2,617,600 (2011 - $2,617,600; 2010 - $109,067) was recognized as revenue related to this upfront payment. As at December 31, 2012, the deferred revenue related to this transaction amounted to $7,743,733 (2011 - $10,361,333). 8.
      Preferred shares of a subsidiary and non-controlling interest: The preferred shares of a subsidiary and the non-controlling interest relate to redeemable and/or convertible preferred shares of Serex in the amount of $800,000. These preferred shares are convertible into common shares of Serex at a price of $3.946 per share. Up to 50% of the preferred shares are redeemable at any time at the option of the preferred shareholders for their issue price, subject to holders with at least 51% of the face value of the preferred shares asking for redemption, and sufficient funds being available in Serex. These redeemable preferred shares in the amount of $400,000 have been presented as a liability in the statements of financial position and are measured at their issue price which is also the redemption value. The non-redeemable portion is presented within equity, separately from equity of the owners of the Corporation, as non-controlling interest. 9.
      Share capital: 2012
        
        2011Authorized:An unlimited number of common shares, at no par valueIssued, outstanding and fully paid:Number of common shares
        
        33,572,442
        
        32,993,302Dollars
        $
        69,705,389
        $
        66,062,961
 67
    NYMOX PHARMACEUTICAL CORPORATIONNotes to Consolidated Financial Statements, ContinuedAs of December 31, 2012 and 2011, and for each of the years in the three-year period endedDecember 31, 2012(In US dollars)
  9.
      Share capital (continued): The holders of common shares are entitled to receive dividends as declared, which is at the discretion of the Corporation, and are entitled to one vote per share at the annual general meeting of the Corporation. The Corporation has never paid any dividends. (a)
      Common Stock Private Purchase Agreement: In November 2011, the Corporation entered into a Common Stock Private Purchase Agreement with an investment company (the "Purchaser") that established the terms and conditions for the purchase of common shares by the Purchaser. In November 2012, this agreement was terminated and a new agreement was concluded with the Purchaser. In general, the Corporation can, at its discretion, require the Purchaser to purchase up to $15 million of common shares over a 24-month period based on notices given by the Corporation. The Corporation must comply with general covenants in order to draw on its facility, including maintaining its stock exchange listing and registration requirements and having no material adverse effects, as defined in the agreement, with respect to the business and operations of the Corporation. The number of shares to be issued in connection with each notice shall be equal to the amount specified in the notice, divided by 97% of the average price of the Corporation's common shares for the five days preceding the giving of the notice. The maximum amount of each notice is $1,000,000 and the minimum amount is $100,000. The Corporation may terminate the agreement before the 24-month term, if it has issued at least $8 million of common shares under the agreement. In 2012, the Corporation issued 558,620 (2011 - 353,407; 2010 – 1,290,078) common shares to the Purchaser for aggregate proceeds of $3,575,000 (2011 - $3,000,000; 2010 - $4,900,000) under the agreements. All issued shares were fully paid. At December 31, 2012, the Corporation can require the Purchaser to purchase up to $15,000,000 of common shares over the remaining 22 months of the agreement, provided the Corporation adheres to its covenants. The Corporation records the equity transaction at the amount received. 68
    NYMOX PHARMACEUTICAL CORPORATIONNotes to Consolidated Financial Statements, ContinuedAs of December 31, 2012 and 2011, and for each of the years in the three-year period endedDecember 31, 2012(In US dollars)
  9.
      Share capital (continued): (b)
      Stock options: The Corporation has established a stock option plan (the “Plan”) for its key employees, its officers and directors, and certain consultants. The Plan is administered by the Board of Directors of the Corporation. The Board may from time to time designate individuals to whom options to purchase common shares of the Corporation may be granted, the number of shares to be optioned to each, and the option price per share. The option price per share cannot involve a discount to the market price at the time the option is granted. On June 13, 2011, the shareholders approved a resolution to increase the maximum number of shares which may be optioned under the stock option plan from 5,500,000 to 7,500,000. The maximum number of shares which may be optioned to any one individual is 15% of the total issued and outstanding common shares. Options under the Plan expire ten years after the grant and vest either immediately or over periods of up to six years, and are equity-settled. As at December 31, 2012, 1,559,500 options could still be granted by the Corporation (2011 - 2,121,500; 2010 – 886,000). 69
    NYMOX PHARMACEUTICAL CORPORATIONNotes to Consolidated Financial Statements, ContinuedAs of December 31, 2012 and 2011, and for each of the years in the three-year period endedDecember 31, 2012(In US dollars)
  9.
      Share capital (continued): (b)
      Stock options (continued): The following table provides the activity of stock option awards during the year and for options outstanding and exercisable at the end of the year, the weighted average exercise price, and the weighted average years to expiration. Options outstandingWeightedWeighted
        
        
        averageaverage
        
        
        remainingexercise
        
        
        contractualNumber
        
        
        price
        
        
        life (in years)Outstanding,January 1, 2010
        4,724,000
        
        $
        3.07
        
        
        6.24Granted
        65,000
        
        
        3.09Expired
        (175,000
        )
        
        3.13Outstanding,December 31, 2010
        4,614,000
        
        $
        3.06
        
        
        5.32Exercised
        (28,000
        )
        
        1.93Granted
        905,000
        
        
        7.10Expired
        (2,500
        )
        
        3.57Surrendered
        (110,000
        )
        
        3.83Outstanding,December 31, 2011
        5,378,500
        
        $
        3.73
        
        
        5.22Exercised
        (8,000
        )
        
        2.76Granted
        590,000
        
        
        6.66Surrendered
        (20,000
        )
        
        2.89Outstanding,December 31, 2012
        5,940,500
        
        $
        4.03
        
        
        4.74Options exercisable
        5,885,500
        
        $
        4.00
        
        
        4.72
 The weighted average share price at the date of exercise for stock options exercised in 2012 was $7.03 (2011 - $7.48; 2010 - no stock options exercised). In 2012, a total of 20,000 options were surrendered (i.e. a “cashless exercise”) to the Corporation (2011 - 110,000; 2010 - nil) in consideration for the issuance of a total of 12,520 common shares (2011 - 38,039; 2010 - nil), whereby the option holders receive a number of shares equivalent in value to the net difference between the strike price on the option and the closing market price on the day before the date of the cashless exercise. 70
    NYMOX PHARMACEUTICAL CORPORATIONNotes to Consolidated Financial Statements, ContinuedAs of December 31, 2012 and 2011, and for each of the years in the three-year period endedDecember 31, 2012(In US dollars)
  9.
      Share capital (continued): (b)
      Stock options (continued): At December 31, 2012, options outstanding and exercisable were as follows: Options outstanding
        Options exercisable
        Exercise price per share
        Expiry date50,000
        50,000
        $ 3.75
        April 28, 201321,000
        21,000
        2.62
        September 9, 2013500,000
        500,000
        3.00
        October 24, 2013175,000
        175,000
        2.82
        June 9, 201630,000
        30,000
        2.74
        July 17, 20163,412,500
        3,412,500
        3.00
        August 24, 201640,000
        40,000
        5.95
        August 23, 201740,000
        40,000
        3.61
        July 16, 201850,000
        50,000
        3.30
        January 23, 20192,000
        2,000
        3.05
        March 24, 201920,000
        20,000
        3.65
        May 14, 201940,000
        40,000
        4.83
        July 9, 201925,000
        25,000
        3.40
        May 3, 202040,000
        40,000
        2.90
        July 16, 2020790,000
        790,000
        7.08
        January 24, 202175,000
        60,000
        6.27
        March 16, 202140,000
        40,000
        9.10
        July 16, 202150,000
        10,000
        8.04
        April 1, 201840,000
        40,000
        6.88
        July 16, 2022500,000
        500,000
        6.51
        October 15, 20225,940,500
        5,885,500
        $ 4.03
  (c)
      Stock-based compensation: 2012
        
        2011
        
        2010Stock options granted in 2006
        $
        29,488
        $
        184,490
        $
        361,160Stock options granted in 2010
        
        -
        
        -
        
        117,705Stock options granted in 2011
        
        46,242
        
        3,820,914
        
        -Stock options granted in 2012
        
        1,886,355
        
        -
        
        -Total stock-based compensation expense recognized
        $
        1,962,085
        $
        4,005,404
        $
        478,865
 The stock-based compensation expense is disaggregated in the statements of operations and comprehensive loss as follows: 2012
        
        2011
        
        2010Stock-based compensation pertaining to general and administrative
        $
        275,386
        $
        1,213,462
        $
        155,901Stock-based compensation pertaining to marketing
        
        389
        
        434,635
        
        4,780Stock-based compensation pertaining to research and development
        
        1,686,310
        
        2,357,307
        
        318,184$
        1,962,085
        $
        4,005,404
        $
        478,865
 71
    NYMOX PHARMACEUTICAL CORPORATIONNotes to Consolidated Financial Statements, ContinuedAs of December 31, 2012 and 2011, and for each of the years in the three-year period endedDecember 31, 2012(In US dollars)
  9.
      Share capital (continued): (c)
      Stock-based compensation (continued): The fair value of the options granted during the years ended December 31, 2012, 2011 and 2010 was determined using the Black-Scholes pricing model using the following weighted average assumptions: 2012
        
        
        2011
        
        
        2010Share price
        $
        6.66
        
        $
        7.10
        
        $
        3.09Exercise price
        
        6.66
        
        
        7.10
        
        
        3.09Risk-free interest rate
        
        1.36%
        
        
        2.56%
        
        
        2.62%Expected volatility
        
        58.67%
        
        
        71.94%
        
        
        68.63%Expected option life in years
        
        5
        
        
        5
        
        
        5Expected option life in years
        
        -
        
        
        -
        
        
        -
 The weighted average grant-date fair value of options granted during the year ended December 31, 2012 was $3.37 per option (2011 - $4.29 per option; 2010 - $1.81 per option). Expected volatility was estimated considering a five-year historic average share price volatility. Expected dividends were determined to be nil, since it is the present policy of the Corporation to retain all earnings to finance operations. 10.
      Commitments and contingencies: (a)
      Operating leases: Minimum lease payments under non-cancelable operating leases that were entered into by the Corporation are payable as follows: Less than one year
        $
        366,432Between one and five years
        
        197,524More than five years
        
        2,904$
        566,860
 In September 2012 and November 2010, the Corporation entered into new operating lease agreements for its Canadian and US premises, both of which will expire on August 31, 2014 and October 31, 2013, respectively. 72
    NYMOX PHARMACEUTICAL CORPORATIONNotes to Consolidated Financial Statements, ContinuedAs of December 31, 2012 and 2011, and for each of the years in the three-year period endedDecember 31, 2012(In US dollars)
  10.
      Commitments and contingencies (continued): (a)
      Operating leases (continued): The current leases for the Canadian and U.S. operations run for two years and three years respectively, with an option to renew the leases after these dates. Lease payments are increased with every renewal to reflect market rentals. During the year ended December 31, 2012, an amount of $370,440 was recognized as an expense in respect of operating leases (2011 - $364,471; 2010 - $300,960). (b)
      Contingencies: In November 2011, two former directors of the Corporation, who ceased to be directors in 2006, served the Corporation with a Motion to Institute Proceedings filed with the Quebec Superior Court seeking an order that they are entitled to exercise options to purchase a total of 125,000 shares of the Corporation at a price of US$4.33 or, in the alternative, damages for lost profit. The Corporation believes that the right to exercise these options ended in May 2007 and that the claims are without merit. The Corporation intends to defend the action vigorously. Accordingly, no provision related to this matter has been recorded in these consolidated financial statements. 11.
      Cost of sales: In 2012, expenses related to inventories recognized as cost of sales amounted to $85,075 (2011 - $108,372; 2010 - $102,547). 12.
      Research tax credits and grants and income taxes: (a)
      Research tax credits and grants: The Corporation was entitled to a grant from the U.S. Government under the Qualifying Therapeutic Discovery Project for its ongoing Phase III clinical trial program for NX-1207 for the treatment of benign prostatic hyperplasia. In April 2011, the Corporation received its full entitlement under this program in the amount of $244,479. 73
    NYMOX PHARMACEUTICAL CORPORATIONNotes to Consolidated Financial Statements, ContinuedAs of December 31, 2012 and 2011, and for each of the years in the three-year period endedDecember 31, 2012(In US dollars)
  12.
      Research tax credits and grants and income taxes (continued): (a)
      Research tax credits and grants (continued): Unused federal research tax credits may be used to reduce future income tax expense, which are not recognized and expire as follows: 2018
        $
        5,2282019
        
        8,5042020
        
        23,0932021
        
        23,4832022
        
        53,5372023
        
        69,3622024
        
        22,5612025
        
        29,0842026
        
        66,3142027
        
        73,2352028
        
        71,5382029
        
        96,9572030
        
        174,4302031
        
        244,7892032
        
        287,333$
        1,249,448
  (b)
      Income taxes: 2012
        
        
        2011
        
        
        2010Current income tax expense for the year
        $
        –
        
        $
        –
        
        $
        2,423,054Recognition of previously unrecognized tax loss
        
        –
        
        
        –
        
        
        (2,423,054
        )Current income tax expense
        
        –
        
        
        –
        
        
        –Deferred tax expense:Origination and reversal of temporary differences
        
        (1,620,431
        )
        
        (1,591,363
        )
        
        (1,834,000
        )Change in unrecognized deductible temporary differences
        
        1,620,431
        
        
        1,591,363
        
        
        1,834,000Deferred tax expense
        
        –
        
        
        –
        
        
        –Total income tax expense
        $
        –
        
        $
        –
        
        $
        –
 74
    NYMOX PHARMACEUTICAL CORPORATIONNotes to Consolidated Financial Statements, ContinuedAs of December 31, 2012 and 2011, and for each of the years in the three-year period endedDecember 31, 2012(In US dollars)
  12.
      Research tax credits and grants and income taxes (continued): (b)
      Income taxes (continued): Reconciliation of effective tax rate: 2012
        
        
        2011
        
        
        2010Net loss for the year, before income taxes
        $
        (7,627,589
        )
        $
        (9,652,389
        )
        $
        (6,536,313
        )Domestic tax rate applicable to the Corporation
        
        26.9%
        
        
        28.4%
        
        
        29.9%Income taxes at domestic tax statutory rate
        
        (2,051,821
        )
        
        (2,741,278
        )
        
        (1,954,358
        )Change in unrecognized deductible temporary differences
        
        1,620,431
        
        
        1,591,363
        
        
        1,834,000Non-deductible expenses and other
        
        431,390
        
        
        1,149,915
        
        
        120,358Income taxes
        $
        –
        
        $
        –
        
        $
        –
 The Corporation’s applicable tax rate is the Canadian combined rates applicable in the jurisdictions in which the Corporation operates. The decrease is due to the reduction of the Federal income tax rate in 2012 from 16.5% to 15.0% and in 2011 from 18% to 16.5%. As at December 31, 2012 and 2011, deferred tax assets not recognized were as follows: 2012
        
        2011
        
        2010Deferred revenue
        $
        2,083,064
        $
        2,787,199
        $
        3,530,597Tax loss carry forward
        
        12,493,652
        
        11,196,417
        
        9,523,940Property and equipment and patents
        
        1,950,980
        
        1,923,879
        
        1,894,480Research and development expenditures
        
        2,031,077
        
        1,799,941
        
        1,581,539Share issue costs
        
        100,081
        
        103,847
        
        123,525Income taxes
        $
        18,658,854
        $
        17,811,283
        $
        16,654,081
 Deferred tax assets have not been recognized in respect to these items because it is not probable that future taxable profit will be available against which the Corporation can utilize the benefits therefrom. The generation of future taxable profit is dependent on the successful commercialization of the Corporation’s products and technologies. 75
    NYMOX PHARMACEUTICAL CORPORATIONNotes to Consolidated Financial Statements, ContinuedAs of December 31, 2012 and 2011, and for each of the years in the three-year period endedDecember 31, 2012(In US dollars)
  12.
      Research tax credits and grants and income taxes (continued): (b)
      Income taxes (continued): At December 31, 2012, the amounts and expiry dates of tax attributes for which no deferred tax assets were recognized are as follows: Federal
        
        ProvincialResearch and development expenditures, without time limitation
        $
        5,370,332
        $
        10,298,546Losses carried forward:2014
        
        581,932
        
        504,5602015
        
        3,544,044
        
        3,544,1962026
        
        3,807,913
        
        3,745,1752027
        
        3,608,571
        
        3,529,0832028
        
        2,750,121
        
        2,750,1212029
        
        3,607,077
        
        3,607,0772031
        
        7,385,581
        
        7,368,7242032
        
        7,336,536
        
        7,319,23432,621,775
        
        32,368,170Other deductible temporary differences:Share issue costs
        
        372,050
        
        372,050Excess of tax value of intellectual property and patent fees over carrying value
        
        7,009,846
        
        7,009,846Excess of tax value of property and equipment over carrying value
        
        265,750
        
        265,750Deferred revenue
        
        7,743,733
        
        7,743,733US losses carried forward:2018
        
        
        
        2,781,4082019
        
        
        
        1,077,9852020
        
        
        
        813,0012021
        
        
        
        664,1292022
        
        
        
        522,1402023
        
        
        
        564,4842024
        
        
        
        353,2042025
        
        
        
        264,2372026
        
        
        
        355,1982027
        
        
        
        372,9422028
        
        
        
        351,2242029
        
        
        
        86,2512030
        
        
        
        541,4572031
        
        
        
        479,7552032
        
        
        
        144,018$
        9,371,433
 76
    NYMOX PHARMACEUTICAL CORPORATIONNotes to Consolidated Financial Statements, ContinuedAs of December 31, 2012 and 2011, and for each of the years in the three-year period endedDecember 31, 2012(In US dollars)
  13.
      Earnings per share: Weighted average number of common shares outstanding: 2012
        
        2011
        
        2010Issued common shares at January 1
        
        32,993,302
        
        32,573,856
        
        31,283,778Effect of stock options exercised
        
        3,704
        
        20,167
        

        –Effect of shares issued
        
        179,179
        
        117,408
        
        656,806Weighted average number of common shares outstanding at December 31
        
        33,176,185
        
        32,711,431
        
        31,940,584
 Diluted loss per share was the same amount as basic loss per share, as the effect of options would have been anti-dilutive, because the Corporation incurred losses in each of the years presented. All outstanding options could potentially be dilutive in the future. 14.
      Capital disclosures: The Corporation's objective in managing capital is to ensure a sufficient liquidity position to finance its research and development activities, general and administrative expenses, working capital and overall capital expenditures, including those associated with patents. The Corporation makes every attempt to manage its liquidity to minimize shareholder dilution when possible. The Corporation defines capital as total equity. To fund its activities, the Corporation has followed an approach that relies almost exclusively on the issuance of common shares and, during 2010, entered into a collaboration agreement. Since inception, the Corporation has financed its liquidity needs primarily through private placements and, since 2003, through a financing agreement with an investment company that has been replaced annually by a new agreement with the same purchaser (see note 9 (a) - Common Stock Private Purchase Agreement). The Corporation intends to access financing under this agreement when appropriate to fund its research and development activities. The financial crisis in the United States and the global economic environment has had a negative impact on the availability of liquidity in the market. Since 2003 through to December 2012, the Purchaser has always complied with the drawdowns made pursuant to the agreement. The Corporation believes that cash balances, funds from operations, as well as funds from the Common Stock Private Purchase Agreement will be sufficient to meet the Corporation’s cash requirements for the next twelve months. The Corporation must comply with general covenants in order to draw on its facility including maintaining its stock exchange listing and registration requirements and having no material adverse effects, as defined in the agreement, with respect to the business and operations of the Corporation. 77
    NYMOX PHARMACEUTICAL CORPORATIONNotes to Consolidated Financial Statements, ContinuedAs of December 31, 2012 and 2011, and for each of the years in the three-year period endedDecember 31, 2012(In US dollars)
  14.
      Capital disclosures (continued): The capital management objectives remain the same as for the previous fiscal year. When possible, the Corporation tries to optimize its liquidity needs by non-dilutive sources, including sales, collaboration agreements, research tax credits and interest income. The Corporation's general policy on dividends is to retain cash to keep funds available to finance its research and development and operating expenses. The Corporation has no debt. The Corporation is not subject to any capital requirements imposed by external parties. 15.
      Financial risk management: This note provides disclosures relating to the nature and extent of the Corporation’s exposure to risks arising from financial instruments, including foreign currency risk, credit risk, interest rate risk and liquidity risk, and to how the Corporation manages those risks. (a)
      Foreign currency risk: The Corporation uses the US dollar as its measurement currency because a substantial portion of revenues, expenses, assets and liabilities of its Canadian and US operations are denominated in US dollars. The Corporation’s equity financing facility is also in US dollars. Foreign currency risk is limited to the portion of the Corporation’s business transactions denominated in currencies other than the US dollar. The Canadian operation has transactions denominated in Canadian dollars, principally relating to salaries and rent. Additional variability arises from the translation of monetary assets and liabilities denominated in currencies other than the US dollar at each statement of financial position date. Fluctuations in the currency used for the payment of the Corporation’s expenses denominated in currencies other than the US dollar (primarily Canadian dollars) could cause unanticipated fluctuations in the Corporation’s operating results, but would not impair or enhance its ability to pay its Canadian dollar denominated obligations. The Corporation’s objective in managing its foreign currency risk is to minimize its net exposures to foreign currency cash flows by transacting with parties in US dollars to the maximum extent possible. The Corporation does not engage in the use of derivative financial instruments to manage its currency exposures. Approximately 57% of expenses that occurred during the year ended December 31, 2012 (2011 – 66%;2010 – 78%) were denominated in US dollars. Foreign exchange fluctuations had no meaningful impact on the Corporation’s results in 2012, 2011 or 2010. 78
    NYMOX PHARMACEUTICAL CORPORATIONNotes to Consolidated Financial Statements, ContinuedAs of December 31, 2012 and 2011, and for each of the years in the three-year period endedDecember 31, 2012(In US dollars)
  15.
      Financial risk management (continued): (a)
      Foreign currency risk (continued): The following table provides significant items exposed to foreign exchange: CA$
        
        2012
        
        
        2011Cash
        $
        167,006
        
        $
        320,662Trade accounts receivable, other receivables and research tax credits receivable
        
        54,169
        
        
        119,192Trade accounts payable and accrued liabilities
        
        (389,256
        )
        
        (399,802
        )$
        (168,081
        )
        $
        40,052
 The following exchange rates were applied for the years ended December 31, 2012, 2011 and 2010: Average rate(twelve months)
        Reporting date rateUS$ - CA$ - December 31, 2012
        0.9996
        0.9949US$ - CA$ - December 31, 2011
        0.9891
        1.0170US$ - CA$ - December 31, 2010
        1.0299
        0.9946
 Based on the Corporation’s foreign currency exposures noted above, varying the above foreign exchange rates to reflect a 5% strengthening of the US dollar would have increased the net loss for the year ended December 31, 2012 by less than $5,000, assuming that all other variables remained constant. An assumed 5% weakening of the US dollar would have had an equal but opposite effect on the amount shown above, on the basis that all other variables remained constant. (b)
        Credit risk:
 Credit risk results from the possibility that a loss may occur from the failure of another party to perform according to the terms of the contract. Financial instruments that potentially subject the Corporation to concentrations of credit risk consist primarily of cash and trade and other accounts receivable. Cash is maintained with high-credit quality financial institutions. For trade accounts receivable, the Corporation performs periodic credit evaluations and typically does not require collateral. Allowances are maintained for potential credit losses consistent with the credit risk, historical trends, general economic conditions and other information. 79
    NYMOX PHARMACEUTICAL CORPORATIONNotes to Consolidated Financial Statements, ContinuedAs of December 31, 2012 and 2011, and for each of the years in the three-year period endedDecember 31, 2012(In US dollars)
  15.
      Financial risk management (continued): (b)
      Credit risk (continued): The Corporation has a limited number of customers. Included in the consolidated statement of financial position are trade accounts receivable of $30,732 (2011 - $31,546), all of which were aged under 45 days. Three customers (2011- four customers) accounted for 86.4% (2011 - 100%) of the trade receivables balance at December 31, 2012, all of whom have a good payment record with the Corporation. No bad debt expense was recorded for the year ended December 31, 2012, December 31, 2011 or December 31, 2010. At December 31, 2012, the Corporation’s maximum credit exposure corresponded to the carrying amount of cash, trade accounts receivable and other receivables. (c)
      Interest rate risk: Interest rate risk is the risk that the fair value or future cash flows of a financial instrument will fluctuate because of changes in market interest rates. Cash bears interest at a variable rate. Trade accounts receivable, other receivables, trade accounts payable and accrued liabilities bear no interest. The Corporation has no other interest-bearing financial instruments. Based on the value of variable interest-bearing cash during the year ended December 31, 2012, an assumed 0.5% increase or 0.5% decrease in interest rates during such period would have had no significant effect on the net loss. (d)
      Liquidity risk: Liquidity risk is the risk that the Corporation will not be able to meet its financial obligations as they fall due. The Corporation manages liquidity risk through the management of its capital structure, as outlined in note 14 - Capital disclosures. The Corporation does not have an operating credit facility and finances its activities through an equity financing agreement with an investment company, as described in note 9 (a) - Common Stock Private Purchase Agreement. The following are the contractual maturities of financial liabilities: Carrying
        
        Less thanamount
        
        1 year
        
        
        1 year to 5 yearsTrade accounts payable and accrued liabilities:December 31, 2012
        $
        1,055,159
        $
        1,055,159
        
        $
        –December 31, 2011
        
        811,492
        
        811,492
        
        
        –
 The redeemable preferred shares in the amount of $400,000 have no specific terms of repayment. 80
    NYMOX PHARMACEUTICAL CORPORATIONNotes to Consolidated Financial Statements, ContinuedAs of December 31, 2012 and 2011, and for each of the years in the three-year period endedDecember 31, 2012(In US dollars)
  16.
      Financial instruments: (a)
      Fair value disclosure: The Corporation has determined that the carrying value of its short-term financial assets and liabilities approximates their fair value due to the immediate or short-term maturity of these financial instruments. (b)
      Finance income and finance costs: 2012
        
        
        2011
        
        
        2010Interest income
        $
        6,180
        
        $
        12,817
        
        $
        1,191Finance income
        
        6,180
        
        
        12,817
        
        
        1,191Interest and bank charges
        
        (10,635
        )
        
        (11,700
        )
        
        (7,078
        )Net foreign exchange loss
        
        (28,483
        )
        
        (28,179
        )
        
        (25,294
        )Finance costs
        
        (39,118
        )
        
        (39,879
        )
        
        (32,372
        )Net finance costs
        $
        (32,938
        )
        $
        (27,062
        )
        $
        (31,181
        )
  17.
      Segment disclosures: The Corporation operates in one reportable segment, which is the Corporation’s strategic business unit -the research and development of products for the aging population. Information regarding the geographic reportable segment is as follows: United
        
        EuropeCanada
        
        States
        
        and otherRevenues:2012
        $
        23,960
        $
        353,397
        $
        2,701,4102011
        
        11,537
        
        437,410
        
        2,664,8682010
        
        15,900
        
        505,897
        
        169,653Property and equipment:December 31, 2012
        
        14,818
        
        300
        
        –December 31, 2011
        
        21,253
        
        907
        
        –
 Revenues are attributed to geographic locations based on location of customers. 81
    NYMOX PHARMACEUTICAL CORPORATIONNotes to Consolidated Financial Statements, ContinuedAs of December 31, 2012 and 2011, and for each of the years in the three-year period endedDecember 31, 2012(In US dollars)
  17.
      Segment disclosures (continued): Major customers: Customers that accounted for greater than 10% of revenues from sales in any of the last three years were as follows: 2012
        
        2011
        
        2010Customer A
        $
        129,803
        $
        191,190
        $
        165,870Customer B
        
        -
        
        -
        
        143,950Customer C
        
        35,468
        
        78,122
        
        23,066
 One customer accounted for 100% of licensing revenues during 2012, 2011, 2010 (refer to note 7). 18.
      Related parties: Executive officers and directors participate in the Corporation’s stock option plan (see note 9 (b)). Executive officers are covered under the Corporation’s health plan. Key management personnel compensation is comprised of: 2012
        
        2011
        
        2010Salaries
        $
        630,346
        $
        667,788
        $
        565,320Short-term employee benefits
        
        9,719
        
        9,259
        
        10,619Stock-based compensation
        
        1,808,628
        
        3,802,911
        
        478,865$
        2,448,693
        $
        4,479,958
        $
        1,054,804
  19.
      Personnel expenses: 2012
        
        2011
        
        2010Salaries
        $
        2,019,020
        $
        1,801,253
        $
        1,314,187Employer contributions
        
        175,360
        
        164,988
        
        116,601Short-term employee benefits
        
        50,305
        
        44,244
        
        43,785Stock-based compensation
        
        1,689,380
        
        3,848,780
        
        478,865$
        3,934,065
        $
        5,859,265
        $
        1,953,438
 The table above includes the compensation figures from the table in note 18. 20.
      Subsequent events: On February 4, 2013, the Corporation issued 153,610 common shares for gross proceeds of $1,000,000 under the Common Stock Private Purchase Agreement referred to in note 9 (a). 82
     ITEM 9. OFFER AND LISTING DETAILS Nymox’s common shares trade on the NASDAQ Stock Market. Nymox’s common shares traded on the NASDAQ National Market from December 1, 1997 until September 16, 1999 when they began trading on the NASDAQ SmallCap Market, now called the NASDAQ Capital Market. Nymox’s common shares also traded on the Montreal Exchange from December 18, 1995 until November 19, 1999. The following tables set out the high and low reported trading prices of the common shares on the NASDAQ Stock Market during the periods indicated. Annual High and Low Market Prices – Past Five Years YEAR
        ANNUAL HIGH
        ANNUAL LOW2008
        $6.390
        $2.5002009
        $7.070
        $2.2002010
        $7.760
        $2.6402011
        $9.890
        $6.0002012
        $8.980
        $6.000
 Quarterly High and Low Market Prices – Past Two Years YEAR
        QUARTERLY PERIOD
        HIGH SALES PRICE
        LOW SALES PRICE2011
        1stQuarter
        $8.805
        $6.0002ndQuarter
        $8.900
        $6.7403rdQuarter
        $9.480
        $6.9104thQuarter
        $9.890
        $7.3202012
        1stQuarter
        $8.980
        $7.5702ndQuarter
        $8.400
        $6.3503rdQuarter
        $7.230
        $5.6934thQuarter
        $8.528
        $6.140
 Monthly High and Low Market Prices – Most Recent Six Months DATE
        MONTHLY HIGH
        MONTHLY LOWOctober, 2012
        $7.490
        $6.140November, 2012
        $8.528
        $6.275December, 2012
        $7.480
        $6.624January, 2013
        $7.650
        $6.500February, 2013
        $6.780
        $5.740March, 2013 (up to and including March 7, 2013)
        $5.380
        $5.118
 ITEM 10. ADDITIONAL INFORMATION Memorandum and Articles of Association Bylaws And Articles Of Incorporation The Corporation’s Articles of Incorporation as amended, which we refer to as our articles of incorporation, are on file with the Corporations Directorate of Industry Canada under Corporation Number 315235-9. Our articles of incorporation do not include a stated purpose and do not place any restrictions on the business that the Corporation may carry on. Directors A director of our Corporation need not be a shareholder. In accordance with our bylaws and the Canada Business Corporations Act, at least 25% of our directors must be residents of Canada. In order to serve as a director, a person must be a natural person at least 18 years of age, of sound mind and not bankrupt. Neither our articles of incorporation or by-laws, nor the Canada Business Corporations Act, impose any mandatory retirement requirements for directors. 83
     Our bylaws and the Canada Business Corporations Act authorize the directors from time to time to determine the remuneration for their services. There is no requirement for an independent quorum. A director who is a party to, or who is a director or officer of or has a material interest in any person who is a party to, a material contract or transaction or proposed material contract or transaction with our Corporation must disclose to the Corporation the nature and extent of his or her interest at the time and in the manner provided by the Canada Business Corporations Act. The Canada Business Corporations Act prohibits such a director from voting on any resolution to approve the contract or transaction unless the contract or transaction: is an arrangement by way of security for money lent to or obligations undertaken by the director for the benefit of the Corporation or an affiliate;relates primarily to his or her remuneration as a director, officer, employee or agent of the Corporation or an affiliate;is for indemnity or insurance for director’s liability as permitted by the Act; oris with an affiliate. Our board of directors may, on behalf of the Corporation and without authorization of our shareholders: borrow money upon the credit of the Corporation;issue, reissue, sell or pledge debt obligations of the Corporation;give a guarantee on behalf of the Corporation to secure performance of an obligation of any person; andmortgage, hypothecate, pledge or otherwise create a security interest in all or any property of the Corporation, owned or subsequently acquired, to secure any obligation of the Corporation. The Canada Business Corporations Act prohibits the giving of a guarantee to any shareholder, director, officer or employee of the Corporation or of an affiliated corporation or to an associate of any such person for any purpose or to any person for the purpose of or in connection with a purchase of a share issued or to be issued by the Corporation or its affiliates, where there are reasonable grounds for believing that the Corporation is or, after giving the guarantee, would be unable to pay its liabilities as they become due, or the realizable value of the Corporation’s assets in the form of assets pledged or encumbered to secure a guarantee, after giving the guarantee, would be less than the aggregate of the Corporation’s liabilities and stated capital of all classes. These borrowing powers may be varied by the Corporation’s bylaws or its articles of incorporation. However, our bylaws and articles of incorporation do not contain any restrictions on or variations of these borrowing powers. Common Shares Our articles of incorporation authorize the issuance of an unlimited number of common shares. They do not authorize the issuance of any other class of shares. The holders of the common shares of our Corporation are entitled to receive notice of and to attend all meetings of the shareholders of our Corporation and have one vote for each common share held at all meetings of the shareholders of our Corporation. Our directors are elected at each annual meeting of shareholders and do not stand for reelection at staggered intervals. The holders of common shares are entitled to receive dividends and the Corporation will pay dividends, as and when declared by our board of directors, out of moneys properly applicable to the payment of dividends, in such amount and in such form as our board of directors may from time to time determine, and all dividends which our board of directors may declare on the common shares shall be declared and paid in equal amounts per share on all common shares at the time outstanding. In the event of the dissolution, liquidation or winding-up of the Corporation, whether voluntary or involuntary, or any other distribution of assets of the Corporation among its shareholders for the purpose of winding up its affairs, the holders of the common shares will be entitled to receive the remaining property and assets of the Corporation. There are no redemption provisions and no liability for further capital calls associated with the Corporation’s common stock. Action Necessary To Change Rights Of Shareholders In order to change the rights of our shareholders, we would need to amend our articles of incorporation to effect the change. Such an amendment would require the approval of holders of two-thirds of the shares cast at a duly called special meeting. For certain amendments such as those creating of a class of preferred shares, a shareholder is entitled to dissent in respect of such a resolution amending our articles and, if the resolution is adopted and the Corporation implements such changes, demand payment of the fair value of its shares. Meetings of Shareholders An annual meeting of shareholders is held each year for the purpose of considering the financial statements and reports, electing directors, appointing auditors and for the transaction of other business as may be brought before the meeting. The board of directors has the power to call a special meeting of shareholders at any time. 84
     Notice of the time and place of each meeting of shareholders must be given not less than 21 days, nor more than 60 days, before the date of each meeting to each director, to the auditor and to each shareholder who at the close of business on the record date for notice is entered in the securities register as the holder of one or more shares carrying the right to vote at the meeting. Notice of meeting of shareholders called for any other purpose other than consideration of the minutes of an earlier meeting, financial statements and auditor’s report, election of directors and reappointment of the incumbent auditor, must state the nature of the business in sufficient detail to permit the shareholder to form a reasoned judgment on and must state the text of any special resolution or by-law to be submitted to the meeting. The only persons entitled to be present at a meeting of shareholders are those entitled to vote, the directors of the Corporation and the auditor of the Corporation. Any other person may be admitted only on the invitation of the chairman of the meeting or with the consent of the meeting. In circumstances where a court orders a meeting of shareholders, the court may direct how the meeting may be held, including who may attend the meeting. Limitations On Right To Own Securities Neither Canadian law nor our articles or by-laws limit the right of a nonresident to hold or vote our shares, other than as provided in the Investment Canada Act (the “Investment Act”), as amended by the World Trade Organization Agreement Implementation Act. The Investment Act generally prohibits implementation of a direct reviewable investment by an individual, government or agency thereof, corporation, partnership, trust or joint venture that is not a “Canadian,” as defined in the Investment Act (a “non-Canadian”), unless, after review, the minister responsible for the Investment Act is satisfied that the investment is likely to be of net benefit to Canada. An investment in our shares by a non-Canadian (other than a “WTO Investor,” as defined below) would be reviewable under the Investment Act if it were an investment to acquire direct control of our Corporation, and the value of the assets of our Corporation were CDN$5.0 million or more (provided that immediately prior to the implementation of the investment the Corporation was not controlled by WTO Investors). An investment in our shares by a WTO Investor (or by a non-Canadian other than a WTO Investor if, immediately prior to the implementation of the investment the Corporation was controlled by WTO Investors) would be reviewable under the Investment Act if it were an investment to acquire direct control of the Corporation and the value of the assets of the Corporation equaled or exceeded a specified amount (the “Review Threshold”). The Review Threshold in 2012 was CDN$330 million and in 2013 is CDN$344 million. A non-Canadian, whether a WTO Investor or otherwise, would be deemed to acquire control of the Corporation for purposes of the Investment Act if he or she acquired a majority of our shares. The acquisition of less than a majority, but at least one-third of our shares, would be presumed to be an acquisition of control of the Corporation, unless it could be established that we were not controlled in fact by the acquirer through the ownership of our shares. In general, an individual is a WTO Investor if he or she is a “national” of a country (other than Canada) that is a member of the World Trade Organization (“WTO Member”) or has a right of permanent residence in a WTO Member. A corporation or other entity will be a “WTO Investor” if it is a “WTO investor-controlled entity,” pursuant to detailed rules set out in the Investment Act. The United States is a WTO Member. Certain transactions involving our shares would be exempt from the Investment Act, including: (a)
      an acquisition of our shares if the acquisition were made in the ordinary course of that person’s business as a trader or dealer in securities;(b)
      an acquisition of control of the Corporation in connection with the foreclosure of a security interest granted for a loan or other assistance and not for any purpose related to the provisions the Investment Act; and(c)
      an acquisition of control of the Corporation by reason of an amalgamation, consolidation or corporate reorganization, following which the direct or indirect control in fact of the Corporation, through ownership of voting interests, remains unchanged. Change of Control There are no provisions of our bylaws or articles of incorporation that would have an effect of delaying, deferring or preventing a change in control of the Corporation and that would operate only with respect to a merger, acquisition or corporate restructuring involving the Corporation. Our bylaws do not contain a provision governing the ownership threshold above which shareholder ownership must be disclosed. Material Contracts The following is a summary of the material contracts to which the Corporation is a party, for the two years ended March 15, 2013. 1.
      The Common Stock Private Purchase Agreement between Nymox Pharmaceutical Corporation and Lorros-Greyse Investments, Ltd. dated November 1, 2012. This agreement established a financing commitment for $15 million over a twenty-four month period starting November 1, 2012. The terms and conditions of this commitment are further described in “Liquidity and Capital Resources” section in Item 5 of this report.2
      The Common Stock Private Purchase Agreement between Nymox Pharmaceutical Corporation and Lorros-Greyse Investments, Ltd. dated November 1, 2011. This agreement established a financing commitment for $15 million over a twenty-four month period starting November 1, 2011. This agreement was replaced by the new agreement above on November 1, 2012. 85
     Exchange Controls Canada has no system of exchange controls. There are no exchange restrictions on borrowing from foreign countries or on the remittance of dividends, interest, royalties and similar payments, management fees, loan repayments, settlement of trade debts or the repatriation of capital. There are no limitations on the rights of non-Canadians to exercise voting rights on their shares of Nymox. Taxation U.S. Federal Income Tax Considerations for U.S. Persons This section contains a summary of certain U.S. federal income tax considerations for U.S. Persons (as defined below) who hold common shares of Nymox. This summary is based upon the Internal Revenue Code of 1986, as amended (the “Code”), Treasury regulations, rulings of the Internal Revenue Service (the “IRS”), and judicial decisions in existence on the date hereof, all of which are subject to change. Any such change could apply retroactively and could have adverse consequences to Nymox and its shareholders. This summary is necessarily general and does not attempt to summarize all aspects of the federal tax laws (and does not attempt to summarize any state or local laws) that may affect an investor’s acquisition of an interest in Nymox. No ruling from the IRS will be requested and no assurance can be given that the IRS will agree with the tax consequences described in this summary. For purposes of this discussion, the term “U.S. Person” means (a) an individual who is a citizen of the United States or who is resident in the United States for United States federal income tax purposes, (b) a corporation or a partnership that is organized under the laws of the United States or any state thereof, (c) an estate the income of which is subject to United States federal income taxation regardless of its source, or (d) a trust (i) that is subject to the supervision of a court within the United States and is subject to the control of one or more United States persons as described in the Code, or (ii) that has a valid election in effect under applicable Treasury regulations to be treated as a United States person. The term “U.S. Holder” means a shareholder of Nymox who is a U.S. Person. The term “foreign corporation” means an entity that is classified as a corporation for U.S. federal income tax purposes and that is not organized under the laws of the United States or any state thereof. This summary does not discuss all United States federal income tax considerations that may be relevant to U.S. Holders in light of their particular circumstances or to certain holders that may be subject to special treatment under United States federal income tax law (for example, insurance companies, tax-exempt organizations, financial institutions, dealers in securities, persons who hold shares as part of a straddle, hedging, constructive sale, or conversion transaction, U.S. Holders whose functional currency is not the U.S. dollar, and U.S. Holders who acquired shares through exercise of employee stock options or otherwise as compensation for services). Furthermore, this summary does not address any aspects of state or local taxation. The tax consequences of an investment in Nymox are complex and based on tax provisions that are subject to change. You are urged to consult with, and must depend upon, your own tax advisors with specific reference to your own tax situations as to the income and other tax consequences of an investment in Nymox. Dividends and gains on sale.Except as described below with respect to the “passive foreign investment corporation” rules, dividends paid by Nymox to a U.S. Holder, without reduction for Canadian withholding taxes, will be included in the gross income of such U.S. Holder, as a dividend, to the extent paid out of current or accumulated earnings and profits, as determined under U.S. federal income tax. Such dividends will not be eligible for the dividend-received deduction generally allowed under the Code to dividend recipients that are U.S. corporations. The amount of any distribution in excess of Nymox’s current and accumulated earnings and profits will first be applied to reduce the U.S. Holder’s tax basis in its Nymox common shares, and any amount in excess of tax basis will be treated as gain from the sale or exchange of the common shares. A dividend paid by Nymox generally will be taxed at the preferential tax rates applicable to long-term capital gains (where the maximum federal rate is currently 20%) if (a) Nymox is a “qualified foreign corporation” as defined in Section 1(h)(11) of the Code, (a “QFC”), (b) the U.S. Holder receiving such dividend is an individual, estate, or trust, and (c) such dividend is paid on common shares that have been held by such U.S. Holder for at least 61 days during the 121-day period beginning 60 days before the “ex-dividend date” (i.e., the first date that a purchaser of such common shares will not be entitled to receive such dividend). Nymox currently meets the definition of a QFC because its common shares are readily tradable on The Nasdaq Stock Market, an established securities market in the United States, provided that Nymox is not a “passive foreign investment corporation” (as described below) for the taxable year during which Nymox pays a dividend or for the preceding taxable year. If Nymox is not a QFC, a dividend paid by Nymox to a U.S. Holder that is an individual, estate, or trust generally will be taxed at ordinary income tax rates (and not at the preferential tax rates applicable to long-term capital gains). The dividend rules are complex, and each U.S. Holder should consult its own financial advisor, legal counsel, or accountant regarding the dividend rules. Except as described below with respect to the “passive foreign investment corporation” rules, any gain recognized by a U.S. Holder on a sale or exchange of Nymox common shares (or on a distribution treated as a sale or exchange) generally will be treated as capital gain. Capital gains of corporations are taxable at the same rate as ordinary income. With respect to non-corporate taxpayers, the excess of net long-term capital gain over net short term capital loss may be taxed at a substantially lower rate than is ordinary income. A capital gain or loss is long-term if the asset has been held for more than one year and short-term if held for one year or less. In addition, the distinction between capital gain or loss and ordinary income or loss is relevant for purposes of limitations on the deductibility of capital losses. 86
     A U.S. Holder generally may claim a credit against its U.S. federal income tax liability for Canadian income tax withheld from dividends received on Nymox common shares. The amount of this credit is subject to several limitations under the Code. Controlled foreign corporation rules.A foreign corporation generally is classified as a “controlled foreign corporation” (a “CFC”) if more than 50% of the corporation’s shares (by vote or value) are owned, directly or indirectly, by “10% U.S. Shareholders”. For this purpose, a “10% U.S. Shareholder” is a U.S. Person that owns, directly or indirectly, shares possessing 10% or more of the voting power in the foreign corporation. Nymox believes that it is not a CFC at the present time. If Nymox were a CFC, each 10% U.S. Shareholder that owns, directly or indirectly through foreign entities, an interest in Nymox generally would be required to include in its gross income for U.S. federal income tax purposes a pro-rata share of any “Subpart F” income earned by Nymox, whether or not such income is distributed by Nymox. Subpart F income generally includes interest, dividends, royalties, gain on the sale of stock or securities and certain other categories of income. Passive foreign investment corporation rules.In general, a foreign corporation is a “passive foreign investment corporation” (a “PFIC”) during a taxable year if 75% or more of its gross income for the taxable year constitutes “passive income” or if 50% or more of its assets (by average fair market value) held during the taxable year produce, or are held for the production of, passive income. In general, any U.S. Person that owns, directly or indirectly, an interest in a foreign corporation will be subject to an interest charge (in addition to regular U.S. federal income tax) upon the disposition by the U.S. Person of, or receipt by the U.S. Person of “excess distributions” with respect to, any shares of the foreign corporation if: (i) the foreign corporation is a PFIC during the taxable year in which such income is realized by the U.S. Person; or (ii) the foreign corporation was a PFIC during any prior taxable year that is included in whole or in part in the U.S. Person’s “holding period” (within the meaning of Section 1223 of the Code) with respect to its interest in the shares of the foreign corporation. Furthermore, the U.S. Person’s share of such gain or “excess distribution” will be taxable as ordinary income. There exist several other adverse tax consequences that may apply to any U.S. Person that owns, directly or indirectly, an interest in a PFIC. A U.S. Person that owns, directly or indirectly, an interest in a PFIC can elect to treat such PFIC as a “qualified electing fund” (a “QEF”) with respect to the U.S. Person. In general, the effect of a QEF election with respect to a PFIC is that, beginning with the first taxable year to which the election applies and in all succeeding taxable years during which the foreign corporation is a PFIC, the U.S. Person is required to include in its income its share of the ordinary earnings and net capital gains of the PFIC. The U.S. Person is not taxable with respect to any distribution by the PFIC from earnings that have been included previously in the U.S. Person’s income under the QEF provisions. If the QEF election is made with respect to the first taxable year in which a U.S. Person owns, directly or indirectly, an interest in the particular PFIC, the adverse tax consequences described in the immediately preceding paragraph (including the interest charge and the treatment of gains as ordinary income) would not apply to the U.S. Person’s interest in that PFIC. In order to make a QEF election, a U.S. Person is required to provide to the IRS certain information furnished by the PFIC. Nymox believes that it has not been a PFIC during any taxable year ending on or before December 31, 2012 and, based on current business plans and financial expectations, Nymox does not believe that it will be a PFIC during its current taxable year. Because PFIC classification cannot be determined until the close of a taxable year, is determined annually, and depends on the application of complex rules which are subject to differing interpretations, there can be no assurance that Nymox has never been and will not become a PFIC for any taxable year during which U.S. Holders hold Nymox common stock. Nymox intends to notify its U.S. Holders within 45 days after the end of any taxable year for which Nymox believes it might be a PFIC. Nymox has further undertaken (i) to provide its U.S. Holders with timely and accurate information as to its status as a PFIC and the manner in which the QEF election can be made and (ii) to comply with all record-keeping, reporting and other requirements so that the U.S. Holders, at their option, may make a QEF election. Each U.S. Person who owns, directly or indirectly, common shares of Nymox is urged to consult its own tax advisor with respect to the advantages and disadvantages of making a QEF election with respect to Nymox. Information Reporting and Backup withholding.Information reporting to the IRS may be required with respect to payments of dividends on the Nymox common shares to U.S. Holders, and with respect to proceeds received by U.S. Holders on the sale of Nymox common shares. A U.S. Holder may be subject to backup withholding at a 28% rate with respect to dividends received with respect to Nymox common shares, or proceeds received on the sale of Nymox common shares through a broker, unless the U.S. Holder (i) demonstrates that it qualifies for an applicable exemption (such as the exemption for holders that are corporations), or (ii) provides a taxpayer identification number and complies with certain other requirements. Any amount withheld from payment to a U.S. Holder under the backup withholding rules generally will be allowed as credit against the U.S. Holder’s U.S. federal income tax liability, if any, and may entitle the U.S. Holder to a refund, provided that the required information is furnished to the IRS. In addition, certain categories of U.S. Holders that hold certain “foreign financial assets” (which may include Nymox common shares), over a certain threshold, must file IRS Form 8938 to report information relating to such assets, subject to certain exceptions. Each U.S. Holder should consult its own financial advisor, legal counsel, or accountant regarding the application of these information reporting and backup withholding rules to it. Medicare Contribution Tax. Recently enacted legislation requires certain U.S. Holders who are individuals, estates or trusts to pay up to an additional 3.8% tax on, among other things, dividends and capital gains for taxable years beginning after December 31, 2012. Each U.S. Holder should consult its own financial advisor, legal counsel or accountant regarding the possible application of this additional tax to income earned with respect to Nymox common shares. 87
     Canadian Federal Income Taxation The following is, as of the date of this report, a summary of the principal Canadian federal income tax considerations generally applicable to shareholders who receive a dividend from Nymox and who, at all relevant times, for purposes of the Income Tax Act (Canada) the (“Tax Act”), hold and will hold Nymox common shares as capital property and deal with Nymox at arm’s length. Nymox’s common shares will generally constitute capital property to a holder unless the holder holds such shares in the course of carrying on a business or the holder has acquired such shares in a transaction or transactions considered to be an adventure in the nature of trade. This summary is based on the current provisions of the Tax Act, the regulations under that act, counsel’s understanding of current administrative and assessing policies of the Canada Customs and Revenue Agency and all specific proposals to amend the Tax Act publicly announced or released by or on behalf of the Minister of Finance (Canada) before the date of this report (“Tax Proposals”). The Tax Act contains certain provisions relating to securities held by certain financial institutions (the “Mark-to-Market Rules”). This summary does not take into account these Mark-to-Market Rules or any amendments to them contained in the Tax Proposals and taxpayers that are “financial institutions” for purposes of those rules should consult their own tax advisors. This summary is not exhaustive of all possible Canadian federal income tax considerations and, except for the Tax Proposals, does not take into account or anticipate any changes in law, whether by legislative, governmental or judicial action, nor does it take into account tax legislation of any province, territory or foreign jurisdiction. This summary is of a general nature only and is not intended to be, nor should it be construed as, legal or tax advice to any particular holder of Nymox common shares. Canadian Residents The following summary is relevant to a holder of Nymox common shares who, for purposes of the Tax Act and any applicable tax treaty or convention, is resident in Canada at all relevant times. Tax Treatment of Capital Gains and Capital Losses for Canadian Residents On a disposition or deemed disposition of a Nymox common share, the holder will realize a capital gain (or capital loss) equal to the amount by which the proceeds of disposition for the Nymox common share exceed (or are less than) the aggregate of any costs of disposition and the adjusted cost base to the holder of the Nymox common share immediately before the disposition. Pursuant to the Tax Act and subject to certain transitional rules which apply in certain circumstances, a holder of Nymox common shares will be required to include in income one-half of the amount of any capital gain (a “Taxable capital gain”) and may deduct one-half of the amount of any capital loss (an “Allowable capital loss”) against Taxable capital gains realized by the holder in the year of the disposition. Allowable capital losses in excess of Taxable capital gains may be carried back and deducted in any of the three preceding years or carried forward and deducted in any following year against taxable capital gains realized in such years to the extent and under the circumstances described in the Tax Act. A capital loss realized by a holder of Nymox common shares that is a corporation, a partnership of which a corporation is a member or a trust of which a corporation is a beneficiary may be reduced by the amount of dividends received in certain circumstances. Capital gains realized by an individual may give rise to a liability for alternative minimum tax. Tax Treatment of Dividends Received by Canadian Residents In the case of a holder of Nymox common shares who is an individual, any dividends received on the common shares will be included in computing his income and will be subject to the gross-up and dividend tax credit rules normally applicable to taxable dividends paid by taxable Canadian corporations. A holder that is a corporation may be liable to pay refundable tax under Part IV of the Tax Act. However, a public corporation which is not controlled, whether because of a beneficial interest in one or more trusts or otherwise, by or for the benefit of an individual (other than a trust) or a related group of individuals (other than trusts) will not be liable to pay refundable tax under Part IV of the Tax Act. In the case of a holder of Nymox common shares that is a corporation, the amount of any capital loss otherwise determined resulting from the disposition of a Nymox common share may be reduced by the amount of dividends previously received or deemed to have been received thereon. Any such restriction will not occur where the corporate holder owned the Nymox common share for 365 days or longer and such holder (together with any persons with whom it did not deal at arm’s length) did not own more than 5% of the shares of any class or series of Nymox at the time the relevant dividends were received or deemed to have been received. Analogous rules apply where a corporation is a member of a partnership or a beneficiary of a trust, which owns Nymox common shares. Shareholders Who Are Not Residents of Canada The following summary is relevant to a holder of Nymox common shares, who, at all relevant times, for purposes of the Tax Act and any applicable tax treaty or convention, is a non-resident or is deemed to be a non-resident of Canada and does not use and is not deemed to use or hold Nymox common shares in the course of carrying on a business in Canada. Special rules, 88
     which are not discussed below, may apply to a non-resident that is an insurer which carries on business in Canada and elsewhere. Dividends Paid To Non-Residents of Canada Under the Tax Act, dividends paid or credited to a non-resident are subject to withholding tax at the rate of 25% of the gross amount of the dividends. This withholding tax may be reduced or eliminated pursuant to the terms of an applicable tax treaty between Canada and the country of residence of the non-resident. For example, for persons who are resident in the United States for purposes of the Canada-United States Income Tax Convention (the “Convention”), the rate of withholding tax on dividends is reduced to 15% generally and 5% when the United States resident is a Corporation that beneficially owns at least 10% of the voting stock of the Corporation paying the dividends. Under the Convention, dividends paid to certain religious, scientific, charitable and other similar tax-exempt organizations and certain organizations that are resident in, and exempt from tax in, the United States are exempt from Canadian non-resident withholding tax. Provided that certain administrative procedures designed to establish with the Canadian tax authorities the right of such entities to benefit from this withholding tax exemption are complied with by the tax-exempt entities prior to the distribution, Nymox would not be required to withhold such tax on such payment. Alternatively, the above-described tax-exempt entities may claim a refund of Canadian withholding tax otherwise withheld by Nymox on the distribution of dividends. Tax Treatment of Capital Gains of Non-Residents of Canada On a disposition or deemed disposition of a Nymox common share, a non-resident holder will realize a capital gain (or capital loss) equal to the amount by which the proceeds of disposition for the Nymox common share exceed (or are less than) the aggregate of any costs of disposition and the adjusted cost base to the non-resident holder of the Nymox common share immediately before the disposition. A non-resident of Canada is liable for Canadian income tax on a capital gain realized on the disposition of property only where that property constitutes “taxable Canadian property”. Pursuant to the Tax Act and subject to certain transitional rules which apply in certain circumstances, one-half of any capital gain from the disposition of taxable Canadian property is subject to Canadian tax. Under the Tax Act, shares of Nymox will not constitute taxable Canadian property unless, at any time, in the five years immediately preceding the disposition, (a) the non-resident holder, persons with whom the non-resident holder did not deal at arm’s length, or the non-resident holder together with all such persons owned (or had a right to acquire) 25% or more of the shares of any class of Nymox and (b) the fair market value of the shares is principally derived, directly or indirectly, from real property situated in Canada. Even in circumstances where shares of Nymox are taxable Canadian property to a non-resident holder, the non-resident holder may be entitled to relief from Canadian tax on any capital gain realized on the disposition thereof pursuant to the terms of an applicable tax treaty between Canada and the country of residence of the non-resident. Nymox believes that the value of its shares is not currently derived principally from real property situated in Canada and it does not expect this to change in the foreseeable future. Provided that the Nymox common shares remain listed on a prescribed stock exchange, which includes the NASDAQ SmallCap Market System, a non-resident holder who disposes of Nymox common shares will not be required to comply with the Canadian notification procedures generally applicable to dispositions of taxable Canadian property. Documents on Display Nymox is subject to the informational requirements of the Securities Exchange Act of 1934, as amended (the”Exchange Act”). In accordance with these requirements, the Corporation files reports and other information with the Securities and Exchange Commission. These materials, including this Annual Report on Form 20-F and the exhibits hereto, may be inspected and copied at the Commission’s Public Reference Room at 100 F Street, N.E., Washington, D.C. 20549. Copies of the materials may be obtained from the Commission’s Public Reference Room at prescribed rates. Information on the operation of the Public Reference Room may be obtained by calling the Commission at 1-800-SEC-0330. The Commission maintains an internet site (http://www.sec.gov) that contains reports, proxy and information statements, and other information regarding issuers, including Nymox, that file electronically with the Commission. We are required to file reports and other information with the securities commissions in all provinces of Canada. You also are invited to read and copy any reports, statements or other information, other than confidential filings, that we file with the provincial securities commissions. These filings are also electronically available from the Canadian System for Electronic Document Analysis and Retrieval ("SEDAR") (http://www.sedar.com), the Canadian equivalent of the SEC's electronic document gathering and retrieval system. This material includes our Management Information Circular for the most recent annual meeting, which provides information including directors’ and officers’, remuneration and indebtedness, principal holders of securities and securities authorized for issuance under equity compensation plans. Additional financial information is provided in our annual financial statements and our Management’s Discussion and Analysis relating to these statements. These documents are also accessible on SEDAR (www.sedar.com). We will provide without charge to each person, including any beneficial owner, on the written or oral request of such person, a copy of any or all documents referred to above which have been or may be incorporated by reference in this Annual Report on Form 20-F (not including exhibits to such incorporated information that are not specifically incorporated by reference into such 89
     information). Requests for such copies should be directed to us at the following address: Nymox Pharmaceutical Corporation, 9900 Cavendish Blvd. Suite 306, St. Laurent, Quebec, Canada, H4M 2V2, Attention: Investor Relations. Telephone (800) 936-9669. Facsimile (514) 332-2227 EMAIL: info@nymox.com ITEM 11. QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK
 Capital disclosures The Corporation's objective in managing capital is to ensure a sufficient liquidity position to finance its research and development activities, general and administrative expenses, working capital and overall capital expenditures, including those associated with patents. The Corporation makes every attempt to manage its liquidity to minimize shareholder dilution when possible. The Corporation defines capital as total equity. To fund its activities, the Corporation has followed an approach that relies almost exclusively on the issuance of common shares and, during 2010, entered into a collaboration agreement. Since inception, the Corporation has financed its liquidity needs primarily through private placements and, since 2003, through a financing agreement with an investment company that has been replaced annually by a new agreement with the same purchaser (see note 9 (a) - Common Stock Private Purchase Agreement). The Corporation intends to access financing under this agreement when appropriate to fund its research and development activities. The financial crisis in the United States and the global economic environment has had a negative impact on the availability of liquidity in the market. Since 2003 through to December 2012, the Purchaser has always complied with the drawdowns made pursuant to the agreement. The Corporation believes that cash balances, funds from operations, as well as funds from the Common Stock Private Purchase Agreement will be sufficient to meet the Corporation’s cash requirements for the next twelve months. The Corporation must comply with general covenants in order to draw on its facility including maintaining its stock exchange listing and registration requirements and having no material adverse effects, as defined in the agreement, with respect to the business and operations of the Corporation. The capital management objectives remain the same as for the previous fiscal year. When possible, the Corporation tries to optimize its liquidity needs by non-dilutive sources, including sales, collaboration agreements, research tax credits and interest income. The Corporation's general policy on dividends is to retain cash to keep funds available to finance its research and development and operating expenses. The Corporation has no debt. The Corporation is not subject to any capital requirements imposed by external parties. Financial risk management This section provides disclosures relating to the nature and extent of the Corporation’s exposure to risks arising from financial instruments, including foreign currency risk, credit risk, interest rate risk and liquidity risk, and to how the Corporation manages those risks. Foreign currency risk The Corporation uses the US dollar as its measurement currency because a substantial portion of revenues, expenses, assets and liabilities of its Canadian and US operations are denominated in US dollars. The Corporation’s equity financing facility is also in US dollars. Foreign currency risk is limited to the portion of the Corporation’s business transactions denominated in currencies other than the US dollar. The Canadian operation has transactions denominated in Canadian dollars, principally relating to salaries and rent. Additional variability arises from the translation of monetary assets and liabilities denominated in currencies other than the US dollar at each statement of financial position date. Fluctuations in the currency used for the payment of the Corporation’s expenses denominated in currencies other than the US dollar (primarily Canadian dollars) could cause unanticipated fluctuations in the Corporation’s operating results, but would not impair or enhance its ability to pay its Canadian dollar denominated obligations. The Corporation’s objective in managing its foreign currency risk is to minimize its net exposures to foreign currency cash flows by transacting with parties in US dollars to the maximum extent possible. The Corporation does not engage in the use of derivative financial instruments to manage its currency exposures. Approximately 57% of expenses that occurred during the year ended December 31, 2012 (2011 - 66%; 2010 – 78%) were denominated in US dollars. Foreign exchange fluctuations had no meaningful impact on the Corporation’s results in 2012, 2011 or 2010. The following table provides significant items exposed to foreign exchange: CA$
        
        December 31, 2012
        
        
        December 31, 2011Cash
        
        $167,006
        
        
        $320,662Trade accounts receivable, other receivables and research tax credits receivable
        
        $54,169
        
        
        $119,192Trade accounts payable and accrued liabilities
        
        $(389,256
        )
        
        $(399,802
        )$(168,081
        )
        
        $40,052
 90
     The following exchange rates were applied for the years ended December 31, 2012, 2011 and 2010: **Average rate (twelve months)**
        **Reporting date rate**US$ - CA$ - December 31, 2012
        0.9996
        0.9949US$ - CA$ - December 31, 2011
        0.9891
        1.0170US$ - CA$ - December 31, 2010
        1.0299
        0.9946
 Based on the Corporation’s foreign currency exposures noted above, varying the above foreign exchange rates to reflect a 5% strengthening of the US dollar would have increased the net loss for the year ended December 31, 2012 by less than $5,000, assuming that all other variables remained constant. An assumed 5% weakening of the US dollar would have had an equal but opposite effect on the amount shown above, on the basis that all other variables remained constant. Credit risk Credit risk results from the possibility that a loss may occur from the failure of another party to perform according to the terms of the contract. Financial instruments that potentially subject the Corporation to concentrations of credit risk consist primarily of cash and trade accounts receivable. Cash is maintained with high-credit quality financial institutions. For trade accounts receivable, the Corporation performs periodic credit evaluations and typically does not require collateral. Allowances are maintained for potential credit losses consistent with the credit risk, historical trends, general economic conditions and other information. The Corporation has a limited number of customers. Included in the consolidated statement of financial position are trade accounts receivable of $30,732 (December 31, 2011 - $31,546), all of which were aged under 45 days. Three customers (December 31, 2011 - four customers) accounted for 86.4% (December 31, 2011 - 100%) of the trade receivables balance at December 31, 2012, all of whom have a good payment record with the Corporation. No bad debt expense was recorded for the year ended December 31, 2012, nor for the year ended December 31, 2011. At December 31, 2012, the Corporation’s maximum credit exposure corresponded to the carrying amount of cash, trade accounts receivable and other receivables. Interest rate risk Interest rate risk is the risk that the fair value or future cash flows of a financial instrument will fluctuate because of changes in market interest rates. Cash bears interest at a variable rate. Trade accounts receivable, other receivables, trade accounts payable and accrued liabilities bear no interest. The Corporation has no other interest-bearing financial instruments. Based on the value of variable interest-bearing cash during the year ended December 31, 2012, an assumed 0.5% increase or 0.5% decrease in interest rates during such period would have had no significant effect on the net loss. Liquidity risk Liquidity risk is the risk that the Corporation will not be able to meet its financial obligations as they fall due. The Corporation manages liquidity risk through the management of its capital structure, as outlined in note 14 - Capital disclosures. The Corporation does not have an operating credit facility and finances its activities through an equity financing agreement with an investment company, as described in note 9 (a) - Common Stock Private Purchase Agreement. The following are the contractual maturities of financial liabilities: Carrying Amount
        Less than 1 year
        1 year to 5 yearsTrade accounts payable and accrued liabilities:December 31, 2012
        $1,055,159
        $1,055,159
        –December 31, 2011
        $811,492
        $811,492
        –
 The redeemable preferred shares in the amount of $400,000 have no specific terms of repayment. ITEM 12. DESCRIPTION OF SECURITIES OTHER THAN EQUITY SECURITIES
 None. PART II ITEM 13. DEFAULTS, DIVIDEND ARREARAGES AND DELINQUENCIES
 None. ITEM 14. MATERIAL MODIFICATIONS TO THE RIGHTS OF SECURITY HOLDERS AND USE OF PROCEEDS
 None. 91
     ITEM 15. CONTROLS AND PROCEDURES
 (a) Disclosure Controls and Procedures. In accordance with Rule 13a-15(b) of the Exchange Act, the Corporation’s management, including the Corporation’s Chief Executive Officer and President, and the Chief Financial Officer and Secretary-Treasurer, evaluated the effectiveness of the design and operation of the Corporation’s disclosure controls and procedures (as defined in Rule 13a-15(e) under the Exchange Act) as of the end of the period covered by this Annual Report on Form 20-F and the Chief Executive Officer and President, and the Chief Financial Officer and Secretary-Treasurer concluded that the disclosure controls and procedures were effective. (b) Management’s Annual Report on Internal Control over Financial Reporting.Management is responsible for establishing and maintaining effective internal control over financial reporting as defined in Rules 13a-15(f) under the Exchange Act. The Corporation’s internal control over financial reporting is designed to provide reasonable assurance to management and our board of directors regarding the preparation and fair presentation of published financial statements. The Corporation’s internal control over financial reporting includes those policies and procedures that (i) pertain to the maintenance of records that, in reasonable detail, accurately and fairly reflect the transactions and dispositions of the assets of the Corporation; (ii) provide reasonable assurance that transactions are recorded as necessary to permit preparation of financial statements in accordance with generally accepted accounting principles, and that receipts and expenditures of the Corporation are being made only in accordance with authorizations of management and directors of the Corporation; and (iii) provide reasonable assurance regarding prevention or timely detection of unauthorized acquisition, use, or disposition of the Corporation’s assets that could have a material effect on the financial statements. Because of its inherent limitations, internal control over financial reporting may not prevent or detect misstatements. Therefore, even those systems determined to be effective can provide only reasonable assurance with respect to financial statement preparation and presentation. Also, projections of any evaluation of effectiveness to future periods are subject to the risk that controls may become inadequate because of changes in conditions, or that the degree of compliance with the policies or procedures may deteriorate. Under the supervision and with the participation of our Chief Executive Officer and our Chief Financial Officer, management conducted an evaluation of the effectiveness of our internal control over financial reporting, as of December 31, 2012, based on the framework set forth in Internal Control-Integrated Frameworkissued by the Committee of Sponsoring Organizations of the Treadway Commission (COSO). Based on its evaluation under this framework, the Chief Executive Officer and the Chief Financial Officer concluded that our internal control over financial reporting was effective as of December 31, 2012. (c) Attestation Report of the Registered Public Accounting Firm. KPMG’s attestation report on the effectiveness of the Corporation’s internal control over financial reporting is included in the financial statements which appear in this annual report. (d) Changes in Internal Controls over Financial Reporting. There have been no changes during the year ended December 31, 2012 in our internal control over financial reporting that have materially affected, or are reasonably likely to materially affect, our internal control over financial reporting. Item 16. RESERVED
  Item 16A. AUDIT COMMITTEE FINANCIAL EXPERT
 Our board of directors has determined that Paul McDonald, the Chairman of our Audit Committee, is an audit committee financial expert and is an independent director under the applicable listing rules of the Nasdaq Stock Market. Item 16B. CODE OF ETHICS
 We have adopted a code of ethics that is applicable to our officers, directors and employees in general and our principal executive officer, principal financial officer, principal accounting officer or controller and persons performing similar functions in particular. The code of ethics can be found on our website, www.nymox.com. Item 16C. PRINCIPAL ACCOUNTANT FEES AND SERVICES
 Our principal independent auditor is KPMG LLP. Fees and Services During the years ended December 31, 2012 and 2011, we paid the following fees for professional services to KPMG LLP: 2012
        
        (CAN$)
        
        2011Audit Fees
        
        197,000
        
        
        
        219,000Audit-Related Fees
        
        10,000
        
        
        
        16,000Tax Fees
        
        93,700
        
        
        
        27,800Other Fees
        
        0
        
        
        
        0Total
        
        300,700
        
        (CAN$)
        
        262,800
 92
     Audit Feesconsisted of professional services rendered for the annual audit of the Corporation’s consolidated financial statements and the quarterly reviews of the Corporation’s interim financial statements, consultation concerning financial reporting and accounting standards, including assistance in preparing the Corporation for compliance with the requirements of IFRS, and services provided in connection with statutory and regulatory filings or engagements. The fees for the annual audit of the Corporation’s consolidated financial statements include fees relating to KPMG’s audit of the effectiveness of the Corporation’s internal control over financial reporting. Audit-Related Feesconsisted of translation services rendered in connection with the Corporation’s financial documents. Tax Feesconsisted of services rendered in connection with the preparation of tax returns of the Corporation and its subsidiaries and general tax advice. Other Fees– there were no other professional services rendered during the years ended December 31, 2012 and 2011. Policy on Pre-Approval of Audit and Non-Audit Services of Independent Auditors Our Audit Committee is responsible for the oversight of our independent auditor's work. Our Audit Committee's policy is to pre-approve all audit and non-audit services provided by KPMG. These services may include audit services, audit-related services, tax services and other services. The Audit Committee appoints the auditors and oversees and fixes the compensation for all such services. KPMG and our management report to the Audit Committee regarding the extent of services actually provided in accordance with the applicable pre-approval, and regarding the fees for the services performed. The Audit Committee approved 100% of the fees listed on the table above. ITEM 16D. EXEMPTIONS FROM THE LISTING STANDARDS FOR AUDIT COMMITTEES
 Not applicable. ITEM 16E. PURCHASES OF EQUITY SECURITIES BY THE ISSUER AND AFFILIATED PURCHASERS
 None. ITEM 16F. CHANGES IN REGISTRANT’S CERTIFYING ACCOUNTANT
 Not applicable. ITEM 16G. CORPORATE GOVERNANCE
 The Corporation complies with all the Nasdaq Stock Market corporate governance requirements. PART III ITEM 17. FINANCIAL STATEMENTS
 Not applicable. ITEM 18. FINANCIAL STATEMENTS
 The financial statements for the two years ended December 31, 2011 and 2012 are included in Item 8 of this report and are incorporated by reference in this item. 93
     ITEM 19. EXHIBITS
 The following exhibits are included with or incorporated by reference into this report: Exhibit
        DescriptionNo.1(a)
        Articles of Incorporation, as amended. (incorporated by reference to Exhibit 3.1 to the Corporation’s Form 20-F filed with the Commission December 9, 1996)1(b)
        Bylaws of the Corporation (incorporated by reference to Exhibit 3.2 to the Corporation’s Form 20-F filed with the Commission December 9, 1996)4(a)
        Memorandum of Agreement between Paul Averback and the Corporation (incorporated by reference to Exhibit 10.1 to the Corporation’s Form 20-F filed with the Commission December 9, 1996)4(b)
        Share Option Plan of the Corporation (incorporated by reference to Exhibit 10.2 to the Corporation’s Form 20-F filed with the Commission December 9, 1996)4(c)
        Research and License Agreement between the Massachusetts General Hospital Corporation and the Corporation (incorporated by reference to Exhibit 10.3 to the Corporation’s Form 20-F filed with the Commission December 9, 1996)4(d)
        Research and License Amendment between the Massachusetts General Hospital Corporation and the Corporation (incorporated by reference to Exhibit 10.5 to the Corporation’s Form 20-F filed with the Commission February 21, 1997)4(e)
        Common Stock Purchase Agreement between Nymox Pharmaceutical Corporation and Jaspas Investments Limited dated November 1, 1999 (incorporated by reference to Exhibit 2.0 to the Corporation’s Form F-1 Registration Statement filed with the Commission February 29, 2000)4(f)
        Registration Rights Agreement between Nymox Pharmaceutical Corporation and Jaspas Investments Limited dated November 1, 1999 (incorporated by reference to Exhibit 2.1 to the Corporation’s Form F-1 Registration Statement filed with the Commission February 29, 2000)4(g)
        Escrow Agreement among Nymox Pharmaceutical Corporation, Jaspas Investments Limited and Epstein, Becker & Green, P.C. dated November 1, 1999 (incorporated by reference to Exhibit 2.2 to the Corporation’s Form F-1 Registration Statement filed with the Commission February 29, 2000)4(h)
        Stock Purchase Warrant to purchase common shares issued to Jaspas Investments Limited dated November 1, 1999 (incorporated by reference to Exhibit 2.3 to the Corporation’s Form F-1 Registration Statement filed with the Commission February 29, 2000)4(i)
        Research and License Agreement between the Rhode Island Hospital Corporation and the Corporation dated May 14, 1999 (incorporated by reference to Exhibit 10.10 to the Corporation’s Form 20-F filed with the Commission May 15, 2000).4(j)
        Research and License Amendment between the Rhode Island Hospital Corporation and the Corporation dated November 19, 2001 (incorporated by reference to Exhibit 10.10 to the Corporation’s Form 20-F filed with the Commission June 28, 2002).4(r)
        Common Stock Private Purchase Agreement between Nymox Pharmaceutical Corporation and Lorros-Greyse Investments, Ltd. dated November 2, 2009. (incorporated by reference to Exhibit 99.1 to the Corporation’s 6-K Report filed with the Commission on March 11, 2010)4(s)
        Common Stock Private Purchase Agreement between Nymox Pharmaceutical Corporation and Lorros-Greyse Investments, Ltd. dated November 1, 2010. (incorporated by reference to Exhibit 4(s) to the Corporation’s Amendment No.1 to 20-F Report filed with the Commission on June 3, 2011).4(t)*
        License and Collaboration Agreement between Nymox Pharmaceutical Corporation and Recordati Ireland Ltd. dated December 16, 2010. (incorporated by reference to Exhibit 4(t) to the Corporation’s Amendment No.1 to 20-F Report filed with the Commission on June 3, 2011)4(u)
        Common Stock Private Purchase Agreement between Nymox Pharmaceutical Corporation and Lorros-Greyse Investments, Ltd. dated November 1, 2011. (incorporated by reference to Exhibit 4(u) to the Corporation’s 6-K Report filed with the Commission on March 15, 2012).4(v)
        Common Stock Private Purchase Agreement between Nymox Pharmaceutical Corporation and Lorros-Greyse Investments, Ltd. dated November 1, 2012. (filed herewith).8
        List of Subsidiaries of Nymox Pharmaceutical Corporation (incorporated by reference to Exhibit 8 to the Corporation’s Form 20-F filed with the Commission June 30, 2004)11
        Code of Business Conduct for the Officers, Directors and Employees of Nymox Pharmaceutical Corporation (incorporated by reference to Exhibit 11 to the Corporation’s Form 20-F filed with the Commission June 30, 2004)12(a)
        Certification of Principal Executive Officer Pursuant to Rule 13a-14(a) or 15d-14(a)12(b)
        Certification of Principal Financial Officer Pursuant to Rule 13a-14(a) or 15d-14(a)13(a)
        Certification of Chief Executive Officer Pursuant to 18 U.S.C. 1350, As Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 200213(b)
        Certification of Chief Financial Officer Pursuant to 18 U.S.C. 1350, As Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002
 *Portions of this exhibit have been omitted pursuant to a confidential treatment request. Omitted portions have been filed separately with the SEC. 94
     SIGNATURES The registrant hereby certifies that it meets all of the requirements for filing on Form 20-F and that it has duly caused and authorized the undersigned to sign this annual report on its behalf. NYMOX PHARMACEUTICAL CORPORATION(Registrant)
  /s/ Paul AverbackPaul AverbackTitle: President
 Date: March 15, 2013 95
     EXHIBIT INDEX -NYMOX PHARMACEUTICAL CORPORATION
    Form 20-F Annual Report Exhibit
        DescriptionNo.1(a)
        Articles of Incorporation, as amended. (incorporated by reference to Exhibit 3.1 to the Corporation’s Form 20-F filed with the Commission December 9, 1996)1(b)
        Bylaws of the Corporation (incorporated by reference to Exhibit 3.2 to the Corporation’s Form 20-F filed with the Commission December 9, 1996)4(a)
        Memorandum of Agreement between Paul Averback and the Corporation (incorporated by reference to Exhibit 10.1 to the Corporation’s Form 20-F filed with the Commission December 9, 1996)4(b)
        Share Option Plan of the Corporation (incorporated by reference to Exhibit 10.2 to the Corporation’s Form 20-F filed with the Commission December 9, 1996)4(c)
        Research and License Agreement between the Massachusetts General Hospital Corporation and the Corporation (incorporated by reference to Exhibit 10.3 to the Corporation’s Form 20-F filed with the Commission December 9, 1996)4(d)
        Research and License Amendment between the Massachusetts General Hospital Corporation and the Corporation (incorporated by reference to Exhibit 10.5 to the Corporation’s Form 20-F filed with the Commission February 21, 1997)4(e)
        Common Stock Purchase Agreement between Nymox Pharmaceutical Corporation and Jaspas Investments Limited dated November 1, 1999 (incorporated by reference to Exhibit 2.0 to the Corporation’s Form F-1 Registration Statement filed with the Commission February 29, 2000)4(f)
        Registration Rights Agreement between Nymox Pharmaceutical Corporation and Jaspas Investments Limited dated November 1, 1999 (incorporated by reference to Exhibit 2.1 to the Corporation’s Form F-1 Registration Statement filed with the Commission February 29, 2000)4(g)
        Escrow Agreement among Nymox Pharmaceutical Corporation, Jaspas Investments Limited and Epstein, Becker & Green, P.C. dated November 1, 1999 (incorporated by reference to Exhibit 2.2 to the Corporation’s Form F-1 Registration Statement filed with the Commission February 29, 2000)4(h)
        Stock Purchase Warrant to purchase common shares issued to Jaspas Investments Limited dated November 1, 1999 (incorporated by reference to Exhibit 2.3 to the Corporation’s Form F-1 Registration Statement filed with the Commission February 29, 2000)4(i)
        Research and License Agreement between the Rhode Island Hospital Corporation and the Corporation dated May 14, 1999 (incorporated by reference to Exhibit 10.10 to the Corporation’s Form 20-F filed with the Commission May 15, 2000).4(j)
        Research and License Amendment between the Rhode Island Hospital Corporation and the Corporation dated November 19, 2001 (incorporated by reference to Exhibit 10.10 to the Corporation’s Form 20-F filed with the Commission June 28, 2002).4(r)
        Common Stock Private Purchase Agreement between Nymox Pharmaceutical Corporation and Lorros-Greyse Investments, Ltd. dated November 2, 2009. (incorporated by reference to Exhibit 99.1 to the Corporation’s 6-K Report filed with the Commission on March 11, 2010)4(s)
        Common Stock Private Purchase Agreement between Nymox Pharmaceutical Corporation and Lorros-Greyse Investments, Ltd. dated November 1, 2010. (incorporated by reference to Exhibit 4(s) to the Corporation’s Amendment No.1 to 20-F Report filed with the Commission on June 3, 2011).4(t)*
        License and Collaboration Agreement between Nymox Pharmaceutical Corporation and Recordati Ireland Ltd. dated December 16, 2010. (incorporated by reference to Exhibit 4(t) to the Corporation’s Amendment No.1 to 20-F Report filed with the Commission on June 3, 2011)4(u)
        Common Stock Private Purchase Agreement between Nymox Pharmaceutical Corporation and Lorros-Greyse Investments, Ltd. dated November 1, 2011. (incorporated by reference to Exhibit 4(u) to the Corporation’s 6-K Report filed with the Commission on March 15, 2012)4(v)
        Common Stock Private Purchase Agreement between Nymox Pharmaceutical Corporation and Lorros-Greyse Investments, Ltd. dated November 1, 2012. (filed herewith).8
        List of Subsidiaries of Nymox Pharmaceutical Corporation (incorporated by reference to Exhibit 8 to the Corporation’s Form 20-F filed with the Commission June 30, 2004)11
        Code of Business Conduct for the Officers, Directors and Employees of Nymox Pharmaceutical Corporation (incorporated by reference to Exhibit 11 to the Corporation’s Form 20-F filed with the Commission June 30, 2004)12(a)
        Certification of Principal Executive Officer Pursuant to Rule 13a-14(a) or 15d-14(a)12(b)
        Certification of Principal Financial Officer Pursuant to Rule 13a-14(a) or 15d-14(a)13(a)
        Certification of Chief Executive Officer Pursuant to 18 U.S.C. 1350, As Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 200213(b)
        Certification of Chief Financial Officer Pursuant to 18 U.S.C. 1350, As Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002
  * Portions of this exhibit have been omitted pursuant to a confidential treatment request. Omitted portions have been filed separately with the SEC. 96