EX-10.1





 Exhibit 10.1 

KARYOPHARM THERAPEUTICS INC. ANNUAL BONUS PLAN 
  

	I.	 Objective 



The Karyopharm Therapeutics Inc. (“Karyopharm” or the “Company”) Annual Bonus Plan (the “Plan”) has been
established to attract, motivate, and retain employees by promoting and rewarding the achievement of key short-term corporate objectives as well as individual performance and to align the interests of employees and stockholders. Cash-based annual
performance bonus awards (“Actual Bonus Awards”) may be granted and earned according to the Plan. 
  

	II.	 Plan Year and Participant Eligibility 



 

	 	A.	 Plan Year 



A Plan Year is defined as the calendar year from January 1 to December 31 (“Plan Year”), although the Plan’s terms
will apply through the date Actual Bonus Awards for the applicable Plan Year are paid. 
  

	 	B.	 Participant Eligibility 



To be a participant for any applicable Plan Year, both Criteria #1 and Criteria #2, as defined below, must be met: 

 

			
	Criteria #1:	 	The individual is considered a regular full-time employee of Karyopharm who is regularly scheduled to work 30 or more hours per week and must have been a regular full-time employee as of September 30 of the applicable Plan
Year.
		
	Criteria #2:	 	The employee must not be eligible to participate in any other cash incentive plan or program, including any sales commission plan.


 Each participant’s Actual Bonus Award shall be prorated based on the number months that the
participant met Criteria #1. The number of months that a participant’s Bonus Award shall be prorated (“Months Eligible”) shall be determined by the following guidelines: 

 

	 	-	 If a participant first meets Criteria #1 on or prior to the fifteenth day of a month prior to
September 30, he or she will be eligible for that month’s full bonus accrual. 


  

	 	-	 If a participant meets Criteria #1 after the fifteenth day of a month prior to September 30, he or she
will not be eligible for that month’s full bonus accrual. 


  

	 	-	 If a participant meets Criteria #1 between October 1 and December 31, the appropriate number of
months based on the two preceding guidelines shall be added to the calculation for the participant’s Actual Bonus Award for the following Plan Year. 



Examples to determine Months Eligible: 

 

			
	 Date Criteria #1 is First Met
	  	 Months Eligible

	August 1	  	5
	August 18	  	4
	September 20	  	3
	October 15	  	Zero in applicable Plan Year. If Participant remains eligible, during the following Plan Year, Months Eligible for that Plan Year shall be 15.



  
 1 













 For a participant to remain eligible to earn an Actual Bonus Award for a Plan Year, the participant must:

  

	 	1.	 Remain an active employee in good standing through the date that Actual Bonus Awards are paid to Participants
(“Payout Date”). Determination of whether an employee is in good standing is solely up to the Company on a case by case basis. Examples of reasons an employee may not be considered in good standing include, but are not limited to, an
employee resigning prior to the Payout Date with a final date of employment after the Payout Date, or an employee is found to be in violation of their applicable Non-Disclosure, Inventions Assignment, Non-Competition, and Non-Solicitation Agreement; and 


  

	 	2.	 Achieve 25% or more of the participant’s Individual Performance (as defined below) for the applicable Plan
Year. 


 Other factors, as discussed in V. Impact of Participant Eligibility, may affect a Participant’s payout. 

 

	III.	 Target Bonus Percentage and Target Bonus Award Calculation 



 

	 	A.	 Target Bonus Percentage 



Each participant’s Target Bonus Percentage is determined by his or her grade as of December 31 of the applicable Plan Year. 

 

					
	 Grade
	  	Target Bonus
Percentage	 
	 14
	  	 	50% – 60%	 
	 13
	  	 	40%	 
	 12
	  	 	30%	 
	 11
	  	 	25%	 
	 10
	  	 	20%	 
	 7 – 9
	  	 	15%	 
	 1 – 6
	  	 	10%	 

  

	 	B.	 Target Bonus Award Calculation 



A participant’s Target Bonus Award is calculated by multiplying the participant’s annual base salary on December 31 of the
applicable Plan Year (“Annual Salary”), Target Bonus Percentage, and Months Eligible out of 12. 
 Target Bonus Award =
Annual Salary x Target Bonus Percentage x (Months Eligible/12) 
 See VI. Example to Calculate Target and Actual Bonus Awards,
below. 

  
 2 














	IV.	 Performance Measures and Weighting 



Actual Bonus Awards can be allocated into two components, corporate and individual. The criteria upon which each of these components are
measured are described below. 
  

	 	A.	 Performance Measures 



Corporate Component 
 On or
before March 31 of a Plan Year, the Compensation Committee of the Company’s Board of Directors (the “Compensation Committee”) shall set corporate goals and weight each corporate goal according to its priority and anticipated
impact on the Company. 
 Following the end of a Plan Year, the Compensation Committee has discretion to determine the Company’s overall
actual corporate performance for that Plan Year as a cumulative percentage of goals achieved (“Corporate Performance”). Partial or excess achievement as compared to the original goal weighting may be determined for each goal, at the
discretion of the Compensation Committee. 
 Individual Component 

For each Plan Year, managers and executives of the Company (or in the case of executive officers of the Company, the Board of Directors or the
Compensation Committee) shall determine each participant’s Individual Performance Goals (“Individual Goals”) and weight each goal according to its priority and anticipated impact on the Company. 

Following the end of a Plan Year, the managers and executives of the Company (or in the case of executive officers of the Company, the Board of
Directors or the Compensation Committee) have discretion to determine the participant’s actual individual performance percentage (“Individual Performance”) for that Plan Year as a cumulative percentage of Individual Goals. Partial or
excess achievement as compared to the original goal weighting may be determined for each goal. 
 In addition to achievement of Individual
Goals, as described above, to determine Individual Performance, managers and executives (or in the case of executive officers of the Company, the Board of Directors or the Compensation Committee) may also consider qualitative factors related to the
Company’s core values and individual performance. 
  

	 	B.	 Weighting 



The weight of corporate and individual components in the calculation of Actual Bonus Award for each Participant will depend on his or her
grade: 
  

									
	 Grade
	  	Component Weight	 
	  	Corporate	 	 	Individual	 
	 14
	  	 	100	% 	 	 	0	% 
	 13
	  	 	85	% 	 	 	15	% 
	 11 – 12
	  	 	70	% 	 	 	30	% 
	 8 – 10
	  	 	60	% 	 	 	40	% 
	 1 – 7
	  	 	50	% 	 	 	50	% 


  
 3 













 If the Compensation Committee, in its sole discretion, determines that the cumulative
percentage of goals achieved does not meet a minimum threshold for payout based on the corporate component, participants may be eligible to receive a payout based on their individual component. 

 

	V.	 Actual Bonus Award Calculation 



Actual Bonus Awards for a participant will be calculated by multiplying a participant’s Target Bonus Award by the sum of the applicable
Corporate and the participant’s Individual Performance (adjusted by each applicable weight). 
 Actual Bonus Award = Target Bonus
Award x [(corporate weight x Corporate Performance) + (individual weight x Individual Performance)] 
 See VI. Example to
Calculate Target and Actual Bonus Awards, below. 
  

	VI.	 Example to Calculate Target and Actual Bonus Awards 



An example participant’s bonus inputs are below: 

 

			
	Annual Base Salary = $85,000	  	Target Bonus Percentage = 10%
	Bonus Eligibility Date = August 1	  	Corporate Performance = 95%
	Months Eligible = 5	  	Individual Performance = 90%
	Grade = 6	  	


 Target Bonus Award: 

Target Bonus Award = Annual Salary x Target Bonus Percentage x (Months Eligible/12) 

 

													
	 Target

Bonus

Award
	 	 	 	 Annual

Base
 Salary
	 	 	 	 Target

Bonus

Percentage
	 	 	 	 Months Eligible

	 $3,542
	 	=	 	$85,000	 	x	 	10%	 	x	 	(5/12)

 Actual Bonus Award: 

Actual Bonus Award = Target Bonus Award x [(corporate weight x Corporate Performance) + (individual weight x Individual Performance)]

  

													
	 Actual

Bonus

Award
	 	 	 	 Target Annual Bonus
	 	 	 	 Weighted Corporate
Performance
Achievement
	 	 	 	 Weighted
Individual
Performance
Achievement

	 	 (50% weighting)
	 	 (50% Weighting)

	 $3,276
	 	=	 	$3,542	 	x	 	[ (50% x 95%)	 	+	 	(50% x 90%)]


  
 4 














	VII.	 Impact of Participant Status 



 

	 	A.	 Terminations 



As described above, a participant must remain employed with Karyopharm through the Payout Date in order to receive an Actual Bonus Award for a
Plan Year. Therefore, if a participant’s employment terminates for any reason prior to the Payout Date, the participant will not be eligible for an Actual Bonus Award, with the following exception: 

 

	 	•	 	 If a participant’s employment ceases by reason of death prior to the Payout Date, the participant’s
estate may receive the Actual Bonus Award, if any, that would have been paid had the participant continued to be employed on the Payout Date, and which amount will be paid on the date that Actual Bonus Awards are paid to other plan participants.



  

	 	B.	 Changes in Target Bonus Percentage 



Participants who are promoted during a Plan Year to a grade with a higher Target Bonus Percentage and/ or different corporate and individual
weighting are eligible for the Target Bonus Percentage and weightings for their grade in effect as of December 31st of the Plan Year. 

Participants who change grades resulting in a lower Target Bonus Percentage as of December 31 are eligible for a prorated Actual Bonus
Award based on the number of months in the Plan Year they were employed in a grade at the higher target percentage plus a prorated Actual Bonus Award based on the number of months in the Plan Year they were employed at the lower Target Bonus
Percentage. 
  

	 	C.	 Changes in Hours 



Participants who have a change in their regularly scheduled hours, described above as Criteria #1, will be eligible for a prorated Actual Bonus
Award based on the number of weeks that their regularly scheduled weekly hours were 30 hours/week or more. 
  

	 	D.	 Leaves of Absence 



Short-Term Disability, FMLA, and other state-specific family and medical leave acts. Participants will continue to be eligible for an
Actual Bonus Award during the period of the leave of absence. 
 Long-Term Disability (“LTD”), including LTD combined with
Workers’ Compensation. Participants who are on LTD in excess of Federal or State mandated family and medical leave provisions, will not be eligible for an Actual Bonus Award for the period of the LTD. 

Personal Unpaid Leaves of Absence. Participants who are on a personal unpaid leave of absence, which is not covered by any of the above
provisions, are not eligible for an Actual Bonus Award for the period of the personal leave of absence. 
  

	 	E.	 Transfers in and Out of the Plan 



Participants who transfer in or out of a position eligible to receive an Actual Bonus Award under the Plan will be eligible for a pro-rated portion of the participant’s Actual Bonus Award based on the number of months they qualified for participation under the Plan during the applicable Plan Year. 

  
 5 














	VIII.	 Payout Date 



The Payout Date for Actual Bonus Awards is made in the calendar year following the applicable Plan Year, on or before March 15th of such following calendar year, to all participants who remain eligible as of the Payout Date, including those on any type of leave of absence and those whose employment has previously terminated
on account of death but who are eligible for an Actual Bonus Award per the terms of the Plan. 
  

	IX.	 Termination, Suspension or Modification and Plan Administration  



The Board of Directors may terminate, suspend or modify (and if suspended, may reinstate with or without modification) all or part of the Plan
at any time, with or without notice to participants. The Compensation Committee has sole authority to administer or interpret the Plan, and the Compensation Committee retains its right to exercise discretion as it sees fit. Notwithstanding
anything herein to the contrary, the Board of Directors may determine that no Actual Bonus Awards shall be paid hereunder for a particular Plan Year or to a particular participant or participants, notwithstanding the level of achievement of
Corporate and/ or Individual Performance for such Plan Year. 
 The Compensation Committee reserves the exclusive right to determine
eligibility to participate in this Plan and to interpret all applicable terms and conditions, including eligibility criteria, performance objectives and payment conditions, for the Company’s executive officers. The Compensation Committee
delegates to each of the Company’s Chief Executive Officer, President, highest human resources officer and highest finance officer the authority to administer, and determine eligibility to participate in, the Plan and interpret all applicable
terms and conditions for employees who are not executive officers of the Company. The determinations and interpretations of the Compensation Committee and its delegates will be conclusive. 

All Actual Bonus Awards are paid from the Company’s general assets. No trust, account or other separate collection of amounts will be
established for the payment of Actual Bonus Awards under the Plan. Actual Bonus Awards are unfunded obligations of the Company, so if and when an Actual Bonus Award becomes due, a participant’s rights to payment are no greater than the
rights of a general unsecured creditor. 
  

	X.	 Other Terms 



Section 409A It is intended that this Plan comply with or be exempt from
Section 409A of the Internal Revenue Code of 1986 (the “Code”), and the Treasury Regulations and IRS guidance thereunder (collectively referred to as “Section 409A”), and notwithstanding anything to the contrary herein,
it shall be administered, interpreted, and construed in a manner consistent with Section 409A. If and to the extent required to comply with Section 409A, no payment or benefit required to be paid under this Plan on account of termination
of a participant’s employment shall be made unless and until the participant incurs a “separation from service” within the meaning of Section 409A. If and to the extent any portion of any payment, compensation or other benefit
provided to a participant in connection with the participant’s employment termination is determined to constitute “nonqualified deferred compensation” within the meaning of Section 409A of the Code, and the participant is a
specified employee as defined in Section 409A(a)(2)(B)(i) of the Code, as determined by the Company in accordance with its procedures, by which determination participants hereby agree to be bound, such portion of the payment, compensation or
other benefit shall not be paid before the earlier of (i) the expiration of the six month period measured from the date of the participant’s “separation from service” (as determined under Section 409A of the Code) or
(ii) the tenth day following the date of the participant’s death following such separation from service (the “New Payment Date”). The aggregate of any payments that otherwise would have been paid to the participant during the
period between the date of separation from service and the New Payment Date shall be paid in a lump sum in the first payroll period beginning after such New Payment Date. Notwithstanding anything herein to the contrary, the Company shall have no
liability to any Plan participant or to any other person in the event that the payments that may be earned hereunder do not comply with or are not exempt from Section 409A. 

  
 6 













 Withholding. The Company shall withhold from any Actual Bonus Award any federal,
state and local income, employment, other similar taxes, or 401(k) deferrals as may be required to be withheld pursuant to any applicable law, regulation, or Company 401(k) policy. 

At-Will Employment. This document sets forth the terms of the Plan and is not intended to be a
contract or employment agreement between you or any other participant and the Company. Nothing in this Plan shall alter the at-will nature of your employment. You are free to resign at any time, and for
any or no reason. Similarly, the Company is free to terminate its employment relationship with you at any time, with or without cause. 

  
 7