Exhibit 4.2

 



1+1 Industry   Canada Industria Canada Date orAmendment (Y_,Y.,..,.Y,..,.Y,...,.&...M,...,.,M...   -DD) Canada Certificate of Amendment Certificat de modification Canada   Business Corporations Act Lol canadlenne sur les socletes par actions AETERNA   ZENTARIS INC. Corporate n11111c I Denomination sociale 264271-9 Corporation   number I Numero de societe I HEREBY CERTIFY that the articles of the JE   CERTIFIE que les statuts de Ia societe above named corporation are amended   under susmentionnee sont modifies aux termes de section 178 of the Canada   Business !'article 178 de Ia Loi canadienne sur les Corporations Act as set   out in the attached socifltes par actions, tel qu'il est indique dans les   articles of amendment. clauses modificatrices ci jointes. Marcie Girouard   Director I Direcleur 2012-10-02 Date de modification (AAAA-MM-JJ) 


    




 










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