SUBMISSION
TYPE     NT-NSAR
LIVE
DOCUMENT-COUNT     001
NOTIFY-INTERNET     jamal.davis@ssmb.com
SROS     NONE
FILER
CIK     0000810271
CCC     vzz#3kxm
/FILER
PERIOD     10/31/2000
DOCUMENT
TYPE     NT-NSAR
TEXT
UNITED STATES
SECRITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

FORM 12b-25

NOTIFICATION OF LATE FILING
(Check One):	[   ] Form 10-K	[   ] Form 20-F	[   ] Form 11-K
		[   ] Form 10-Q	[ X ] Form N-SAR

	For Period Ended: October 31, 2000
	[   ] Transition Report on Form 10-K
	[   ] Transition Report on Form 20-F
	[   ] Transition Report on Form 11-K
	[   ] Transition Report on Form 10-Q
	[   ] Transition Report on Form N-SAR
	For the Transition Period Ended: _____________________________

Read Instruction (on back page) Before Preparing From. Please Print or
Type. Nothing in this form shall be construed to imply that the
Commission has verified any information contained herein.

If the notification relates to a portion of the filing checked above,
identify the Item(s) to which the notification relates:


PART I - REGISTRANT INFORMATION
Smith Barney Investment Series Trust
Full Name of Registrant


Former Name if Applicable

125 Broad Street
Address of Principal Executive Office (Street and Number)

New York, NY 10004
City, State and Zip Code

RART II - RULES 12b-25(b) and (c)

If the subject report could not be filed without unreasonable effort or
expense and the registrant seeks relief pursuant to Rule 12b-25(b), the
following should be completed.  (Check box if appropriate)

[   ]	 (a)The reasons described in reasonable detail in Part III
            of this form could not be eliminated without unreasonable
            effort or expense;
[   ]	 (b)The subject annual report, semi-annual report, transition
            report on Form 10-K, Form 20-F 11-K, Form N-SAR, or
            portion thereof, will be filed on or before the fifteenth
            calendar day following the prescribed due date; or the
            subject quarterly report of transition report on Form
            10-Q, or portion thereof will be filed on or before the
            fifth calendar day following the prescribed due date; and
[   ]	 (c)The accountant's statement of other exhibit required by
            Rule 12b-25(c) has been attached if applicable.

PART III - NARRATIVE

State below in reasonable detail the reasons why the Form 10-K, 10-Q,
N-SAR, or the transition report or portion thereof, could not be filed
within the prescribed time period. (Attach Extra Sheet if Needed)

PART IV - OTHER INFORMATION

(1) Name and telephone number of person to contact in regard to this
notification

Marianne Motley	    212	            291-2772
(Name)          (Area Code)     (Telephone Number)

(2) Have all other periodic reports required under Section 13 or
15(d) of the Securities Exchange Act of 1934 of Section 30 of the
Investment Company Act of 1940 during the preceding 12 months (or
for such shorter) period that the registrant was required to file
such reports) been filed?  If answer is no identify report(s).
				[   ]Yes	[   ]No


(3)	Is it anticipated that any significant change in results of
operations from the corresponding period for the last fiscal year
will be reflected by the earnings statements to be included in
the subject report or portion thereof?
				[   ]Yes 	[   ]No

	If so, attach an explanation of the anticipated change, both
narratively and quantitatively, and , if appropriate, state the
reasons why a reasonable estimate of the results cannot be made.



Smith Barney Investment Series Trust
(Name of Registrant as Specified in Charter)
has caused this notification to be signed on its behalf by the
undersigned hereunto duly authorized.


Date:	December 28, 2000		By: Marianne Motley

INSTRUCTION: The form may be signed by an executive officer of the
registrant or by any other duly authorized representative. The name
and title of the person signing the form shall be typed or printed
beneath the signature. If the statement is signed on behalf of the
registrant by an authorized representative (other than an executive
officer), evidence of the representative's authority to sign on
behalf of the registrant shall be filed with the form.
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/SUBMISSION