Specimen Common Stock Certificate



 Renovis 
  
 INCORPORATED UNDER THE LAWS OF THE STATE OF DELAWARE 
  

			
		
	 [SEAL APPEARS HERE]
	  	[SEAL APPEARS HERE]

  

			
	 	  	SEE REVERSE SIDE
	 	  	FOR CERTAIN DEFINITIONS  

	 	 	

	 	  	CUSIP 759885 10 6
	 	 	


  
 THIS CERTIFIES THAT 
  
 is the owner of 
  
 FULLY PAID AND NON-ASSESSABLE COMMON SHARES, $0.001 PAR VALUE, OF 
  
 RENOVIS, INC. 
  
 transferable on the books of the Corporation by the holder hereof in person or by Attorney upon surrender of this certificate properly endorsed. This certificate is not valid
unless countersigned by the Transfer Agent and Registrar.  
  
 IN WITNESS WHEREOF, the said Corporation has caused this certificate to be signed by facsimile signatures of its duly authorized officers. 
  
 Dated: 
  

									
			
	 /s/    COREY S.
GOODMAN        

	 	 	 	 /s/    ALAN C.
MENDELSON        


	PRESIDENT AND CHIEF EXECUTIVE OFFICER	 	 	 	SECRETARY

  

			
		
	COUNTERSIGNED AND REGISTERED:	  	 
		
	                  WELLS FARGO BANK, N.A.	  	 
		
	 	  	TRANSFER AGENT
		
	 	  	AND REGISTRAR
		
	BY	  	 
		
	 	  	AUTHORIZED SIGNATURE

  









 The following abbreviations, when used in the inscription on the face of this certificate, shall be construed as though they were
written out in full according to applicable laws or regulations: 

							
	TEN COM	 	–	  	 as tenants in common
	  	 UTMA   –  
             Custodian             
                   (Cust)
                  (Minor)

				
	TEN ENT	 	–	  	 as tenants by entireties
	  	                 under Uniform Transfer to Minors

				
	JT TEN	 	–	  	 as joint tenants with right of survivorship
 and not as tenants in common
	  	                 Act
                                        
    
                                        
 (State)


 Additional abbreviations may also be used though not in the above list. 

 For value received                  hereby sell, assign
and transfer unto 
  
 PLEASE INSERT SOCIAL SECURITY OR OTHER 
 IDENTIFYING NUMBER OF ASSIGNEE 
  
                                       
                                        
                                        
                                        
                                        
                    
  
                                       
                                        
                                        
                                        
                                        
                    
 PLEASE PRINT OR TYPEWRITE NAME
AND ADDRESS INCLUDING POSTAL ZIP CODE OF ASSIGNEE 
  
                                       
                                        
                                        
                                        
                                        
                    
  
                                       
                                        
                                        
                                        
                                        
                    
  
                                       
                                        
                                        
                                        
                                        
                    
 Shares of the capital stock represented
by the within Certificate, and do hereby irrevocably constitute and appoint
                                        
                                        
                                        
   Attorney to transfer the said stock on the books of the within-named Corporation with full power of substitution in the premises. 
  

									
			
	 Dated
	 	 	 	

			
	 	 	 	 	

	 	 	 	 	 	 	NOTICE: THE SIGNATURE TO THIS ASSIGNMENT MUST CORRESPOND WITH THE NAME AS WRITTEN UPON THE FACE OF THE CERTIFICATE IN EVERY PARTICULAR WITHOUT ALTERATION OR ENLARGEMENT OR ANY CHANGE
WHATEVER.

  
 SIGNATURE GUARANTEED 
  

			
	
	 	 
	ALL GUARANTEES MUST BE MADE BY A FINANCIAL INSTITUTION (SUCH AS A BANK OR BROKER) WHICH IS A PARTICIPANT IN THE SECURITIES TRANSFER AGENTS MEDALLION PROGRAM (“STAMP”), THE NEW YORK STOCK
EXCHANGE, INC. MEDALLION SIGNATURE PROGRAM (“MSP”), OR THE STOCK EXCHANGES MEDALLION PROGRAM (“SEMP”) AND MUST NOT BE DATED. GUARANTEES BY A NOTARY PUBLIC ARE NOT ACCEPTABLE.