<PAGE>

                                                                   Exhibit 10.30

[*] CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY
    BRACKETS, HAS BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND
    EXCHANGE COMMISSION PURSUANT TO RULE 406 OF THE SECURITIES EXCHANGE ACT OF
    1933, AS AMENDED.

AZ AND CK CONFIDENTIAL

                       COLLABORATION AND LICENSE AGREEMENT

         THIS COLLABORATION AND LICENSE AGREEMENT (this "AGREEMENT") is made and
entered into as of the 15th day of December, 2003 (the "EFFECTIVE DATE") by and
between Cytokinetics, Inc. a Delaware corporation, having a place of business at
280 East Grand Avenue, South San Francisco, CA 94080 ("CK") and AstraZeneca AB,
a company incorporated in Sweden under no. 556011-7482 with offices at S-151 85
Sodertalje, Sweden ("AZ"). CK and AZ are each referred to herein by name or as a
"PARTY" or, collectively, as "PARTIES."

                                    RECITALS

         A.       WHEREAS CK has developed Cytometrix(TM)* cellular phenotyping
technologies for compound profiling (the "CM SYSTEM," as further defined below);

         B.       WHEREAS AZ is performing internal projects aimed at the
discovery and development of novel therapeutic products; and

         C.       WHEREAS CK and AZ wish to collaborate on a research program
utilizing AZ and CK's knowledge, skills, and proprietary technology to develop a
module of the CM System for use as an in vitro predictor of hepatotoxicity.

         NOW, THEREFORE, in consideration of the promises and mutual covenants
herein contained, and for other good and valuable consideration, the receipt and
sufficiency of which are hereby acknowledged, the Parties hereto agree as
follows:

                            ARTICLE I - DEFINITIONS

         Unless otherwise specifically provided in this Agreement, the following
capitalized terms shall have the following meanings as used in this Agreement:

         1.1      "AFFILIATE" means, with respect to a Person, any Person that
Controls, is Controlled by or is under common Control with such first Person.
For purposes of this Section 1.1 only, "CONTROL" means (a) to possess, directly
or indirectly, the power to direct the management or policies of a Person,
whether through ownership of voting securities or by contract relating to voting
rights or corporate governance, or (b) to own, directly or indirectly, fifty
percent (50%) or more of the outstanding voting securities or other ownership
interest of such Person; provided

----------
   *Cytometrix(TM) is a trademark of Cytokinetics, Inc

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AZ AND CK CONFIDENTIAL

that, if local law in any country other than the United States requires a
maximum percentage of local ownership such that the maximum percentage that may,
under such local law, be owned by foreign interests is less than fifty percent
(50%), "CONTROL" means to own the maximum ownership percentage that may, under
such local law, be owned by foreign interests.

         1.2      "APPLICABLE LAW" means the applicable laws, rules and
regulations, including any rules, regulations, guidelines or other requirements
of regulatory authorities that may be in effect from time to time.

         1.3      "AZ BACKGROUND TECHNOLOGY" means any and all Technology
Controlled by AZ as of the Effective Date or during the Research Term
(regardless of when disclosed) and described on EXHIBIT 1.3, or included as AZ
Background Technology pursuant to Section 3.5. The AZ Background Technology
excludes (i) any and all Collaboration Technology and Collaboration Knowledge,
and (ii) any and all Technology provided to CK hereunder by or on behalf of AZ
consisting of General Methods.

         1.4      "AZ COMPOUND" means each Compound intended or provided for use
in the Research Program hereunder by or for AZ, in each case identified by an AZ
Compound identifier listed on EXHIBIT 1.4 and identified therein as Public or
Proprietary, including additional AZ Compounds added pursuant to Section 3.2 and
excluding Compounds removed as Proscribed Compounds pursuant to Section 3.2.

         1.5      "AZ COMPOUND DATA" means data proprietary to AZ and
conclusions derived by or for AZ from such data (other than Collaboration
Technology), existing as of the Effective Date or during the Research Term,
comprised of data and information that describes or otherwise relates to an AZ
Compound and (i) described in, included or required to be provided to CK under
Section 3.2 or the Research Plan, or (ii) otherwise disclosed by AZ to CK in
accordance with this Agreement.

         1.6      "AZ FACILITY(IES)," when used in the singular, means the
primary location at which AZ performs the Research Program, as designated and
updated in accordance with Section 2.3 from time to time; and when used in the
plural, means any and all of AZ's facilities, also as designated and updated in
accordance with Section 2.3 from time to time.

         1.7      "AZ IMPROVEMENTS" means Improvements that are made during the
Pilot License Term that are adaptations or modifications to the Cytometrix(TM)
Hepatotoxicity Module required solely for purposes of achieving compatibility of
the Cytometrix(TM) Hepatotoxicity Module with AZ's information technology or
bioinformatics infrastructure.

         1.8      "AZ KNOWLEDGE" means Technology provided to CK by or on behalf
of AZ during the Research Term for use in the Research Program, which in each
case is not AZ Background Technology, Collaboration Technology, AZ Compounds or
AZ Compound Data.

         1.9      "CHANGE OF CONTROL" means an event in which (i) any Person,
other than the shareholders of a Party as of the Effective Date of the
Agreement, acquires or becomes the beneficial owner of more than fifty percent
(50%) of the voting securities of that Party, (ii) a

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AZ AND CK CONFIDENTIAL

Party enters into a merger, consolidation or other similar transaction with
another Person or Persons and is not the surviving entity in such transaction,
or (iii) a Party sells to any Person(s) in one or more related transactions all
or substantially all of its consolidated total assets. The public or private
sale of equity securities by the current shareholders of a Party in a single or
related series of transactions shall not constitute a Change in Control unless
as a result of such sale or sales one Person or group of Persons acting in
concert attains control of that Party or acquires or becomes the beneficial
owner of more than fifty percent (50%) of the voting securities of that Party or
such entity into which that Party has merged or consolidated.

         1.10     "CK BACKGROUND TECHNOLOGY" means any and all Technology
Controlled by CK as of the Effective Date or during the Research Term
(regardless of when disclosed) and consisting of the CM System, embodied in CK's
proprietary standard operating procedures described on EXHIBIT 1.10, or included
as CK Background Technology pursuant to Section 3.5. The CK Background
Technology excludes (i) any and all Collaboration Technology and Collaboration
Knowledge, (ii) any and all Technology primarily related to the Prohibited
Field, and (iii) Technology provided to AZ hereunder by or on behalf of CK
consisting of General Methods.

         1.11     "CK COMPOUND" means each Compound intended or provided for use
in the Research Program hereunder by or for CK, in each case identified by a CK
Compound identifier listed on EXHIBIT 1.11 and identified therein as Public or
Proprietary, including additional CK Compounds added pursuant to Section 3.2,
and excluding CK Compounds removed as Proscribed Compounds pursuant to Section
3.2.

         1.12     "CK COMPOUND DATA" means data proprietary to CK and
conclusions derived by or for CK from such data (other than Collaboration
Technology), existing as of the Effective Date or during the Research Term,
comprised of data and information that describes or otherwise relates to a CK
Compound, and (i) described in, included, or required to be provided to AZ under
the Research Plan, or (ii) otherwise disclosed by CK to AZ in accordance with
this Agreement.

         1.13     "CK FACILITY" means the primary location at which CK performs
the Research Program, as designated and updated in accordance with Section 2.2
from time to time.

         1.14     "CK KNOWLEDGE" means Technology provided to AZ by or on behalf
of CK during the Research Term for use in the Research Program, which in each
case is not CK Background Technology, Collaboration Technology, Collaboration
Knowledge, CK Compounds or CK Compound Data.

         1.15     "CM SYSTEM" means that certain Technology Controlled by CK as
of the Effective Date or during the Research Term consisting of the
Cytometrix(TM) cellular phenotyping technologies system employing
high-throughput fluidics, automation, microscopy, imaging analysis and advanced
bioinformatics to automate cellular phenotyping, as described in more detail on
EXHIBIT 1.15.

         1.16     "COLLABORATION KNOWLEDGE" means all Technology conceived
and/or reduced to practice or otherwise generated through activities performed
under or in the scope of the

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AZ AND CK CONFIDENTIAL

Research Program to the extent consisting of General Methods. For clarity,
Collaboration Knowledge excludes all Technology developed in the course of the
Exempt Activities.

         1.17     "COLLABORATION TECHNOLOGY" means all Technology conceived
and/or reduced to practice or otherwise generated through activities performed
under or in the scope of the Research Program, solely by either AZ or CK or
jointly by the Parties, excluding Collaboration Knowledge and excluding any
Technology developed in the course of the Exempt Activities.

         1.18     "COMPOUND" means a unique chemical entity.

         1.19     "COMPOUND DATA" means the AZ Compound Data or the CK Compound
Data, as applicable, and similar data generated pursuant to the Research
Program.

         1.20     "CONTRACT YEAR" means a year of 365 days (or 366 days in a
leap year) beginning on the Effective Date and ending one (1) year thereafter
and so on year-by-year. "CONTRACT YEAR ONE" means the first such year; "CONTRACT
YEAR TWO" means the second such year, and so on, year-by-year.

         1.21     "CONTROL" means, with respect to any item of Technology, or a
particular Compound, or the related Intellectual Property Rights thereto, the
possession of the right, whether directly or indirectly, and whether by
ownership, license or otherwise, to disclose, deliver, assign, or grant a
license, sublicense or other right to or under such applicable Technology,
Compound or related Intellectual Property Rights, of the scope and as provided
for herein, without any of the following: (i) violating the terms of any
agreement or other arrangement with any Third Party existing as of the Effective
Date; (ii) the granting Party being required to pay any royalty or other
consideration to any Third Party that would not have been required had the
applicable right or license not been provided under this Agreement; or (iii)
violating any law, regulation, rule, code, order or other requirement of any
federal, state, foreign, local, or other government body or the need for any
additional permits, payments, authorizations, or approvals under any such law,
regulation, rule, code, order or requirement.

         1.22     "CYTOMETRIX(TM) HEPATOTOXICITY MODULE" or "CHM" means that
certain module of the CM System developed in the course of performance and scope
of the Research Program, and directed to in vitro predictions of hepatotoxicity
(i.e., in vitro image-based assays that can be used to support selection of
chemical entities for drug discovery and development that may have a lower
intrinsic potential to cause liver toxicity).

         1.23     "DELIVERABLES" means certain identified items required to be
delivered or provided by one Party to the other pursuant to the Research
Program, as set forth in EXHIBIT 1.23.

         1.24     "EFFECTIVE DATE" means the date as set forth in the preamble
to this Agreement.

         1.25     "EXEMPT ACTIVITIES" means, with respect to the specific Party
identified on EXHIBIT 1.25, the corresponding activities set forth on EXHIBIT
1.25.

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AZ AND CK CONFIDENTIAL

         1.26     "FIELD" means the use of imaging-based cellular phenotyping,
together with the use of analysis for the in vitro prediction of hepatotoxicity
to support drug discovery and development. For the avoidance of doubt, "FIELD"
excludes, without limitation, (i) any and all [*] applications (i.e., the direct
or indirect [*]), (ii) [*] applications (i.e., the direct or indirect [*]
whether by [*], [*], [*] or otherwise), (iii) any and all [*], [*] or similar
applications, or uses as a commercial service (e.g., as a service bureau or on
behalf of any Third Party) or product, and (iv) the use of the CM System or any
other Cytometrix(TM) cellular phenotyping and/or analysis technologies or
similar technologies (other than the Cytometrix(TM) Hepatotoxicity Module) to
investigate and engage in activities related to discovery and validation of any
[*] and/or [*].

         1.27     "FTE" means the equivalent of one researcher employed by CK or
AZ having the requisite skills to fulfill CK's or AZ's obligations under this
Agreement and devoting the equivalent hours of a full time employee. For
purposes of this Agreement, "full time" shall mean 1880 hours per year as
determined in accordance with the applicable Party's regular project hour
reporting system.

         1.28     "FULL LICENSE" has the meaning set forth in Section 5.7.

         1.29     "FULL LICENSE TERM" means the period of time during which the
Full License is in effect, beginning as of the date the Full License is first
effective.

         1.30     "GENERAL METHODS" means (a) methods or techniques for (i) cell
culture, (ii) cell plating and conditions therefor, (iii) automation, (iv)
automated image acquisition, (v) variable exposure of cells to treatment, and
(vi) automated addition of treatment and stains; and (b) general knowledge of
use to practitioners of toxicological studies or cellular phenotyping and
analysis.

         1.31     "IMPROVEMENT" means any improvement, adaptation, modification
or upgrade arising during the Pilot License Term and/or the Full License Term.

         1.32     "INTELLECTUAL PROPERTY RIGHTS" means any and all intellectual
property rights in, to, or arising out of any (i) Patents; (ii) trade secrets;
(iii) know-how (iv) copyrights, copyright registrations, or any national or
regional application therefor, in any territory, or any other right
corresponding thereto throughout the world, including moral rights; or (v) any
other intellectual property or proprietary right anywhere in the world,
including rights in or to any data bases, data collections (including knowledge
databases) or software (including any source code or object code form).

         1.33     "JOINT RESEARCH COMMITTEE" or "JRC" means the committee
established pursuant to Section 2.4 herein.

         1.34     "JOINT STEERING COMMITTEE" or "JSC" means the committee
established pursuant to Section 2.5 herein.

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AZ AND CK CONFIDENTIAL

         1.35     "PATENT" means any and all rights under any of the following,
whether existing now or in the future: (i) all national, regional and
international patents and patent applications, including provisional patent
applications, utility model, design registration, certificate of invention,
patent of addition or substitution, or other governmental grant for the
protection of inventions or industrial designs anywhere in the world, including
any reissue, renewal, re-examination or extension thereof; and (ii) any
application for any of the foregoing, including any international, provisional,
divisional, continuation, continuation-in-part, or continued prosecution
application.

         1.36     "PERFORMANCE CRITERIA" means the functional criteria for
performance of the Cytometrix(TM) Hepatotoxicity Module, as set forth in EXHIBIT
1.36, as may be revised by the JRC or by mutual written agreement of the
Parties.

         1.37     "PERSON" means an individual, sole proprietorship,
partnership, limited partnership, limited liability partnership, corporation,
limited liability company, business trust, joint stock company, trust,
incorporated association, joint venture or similar entity or organization,
including a government or political subdivision, department or agency of a
government.

         1.38     "PILOT LICENSE" has the meaning set forth in Section 5.6.1.

         1.39     "PILOT LICENSE TERM" is the period during which the Pilot
License is effective, (A) commencing on the earlier of (i) the date after the
last day of the Research Term or (ii) the date that the prototype Cytometrix(TM)
Hepatotoxicity Module, installed at the CK Facility and used in connection with
CK's infrastructure and instrumentation, first meets the Performance Criteria
therefor, as determined pursuant to Section 3.4, and then (B) continuing until
the earlier of (x) the date that the Cytometrix(TM) Hepatotoxicity Module,
installed at the AZ Facility and used in connection with AZ's infrastructure and
instrumentation, first meets the Performance Criteria therefor, as determined
pursuant to Section 3.4, or (y) the first anniversary of the date of
commencement (as described in clause (A) above) of the Pilot License Term,
subject to extension by mutual written agreement of the Parties.

         1.40     "PRINCIPAL SCIENTIST" means the AZ Principal Scientist or the
CK Principal Scientist, as applicable, as each is defined in Sections 2.3.2 and
2.2.2, respectively.

         1.41     "PROHIBITED FIELD" means any and all research, development or
commercialization activities directed toward any [*] or products for any such
applications.

         1.42     "PROPRIETARY" means (i) with respect to a Compound, that the
Party providing such Compound hereunder Controls Patents which specifically
recite and specifically, but not solely generically, claim the making,
possession, use, sale, import or export of such Compound or has maintained, as a
trade secret, the composition of matter of such Compound, and (ii) with respect
to Compound Data, such data has been maintained as a trade secret by the
providing Party.


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AZ AND CK CONFIDENTIAL

         1.43     "PROSCRIBED COMPOUND" means:

                  1.43.1   with respect to an AZ Compound, a Compound that is
marked with the development flag in the [*] system. The development flag shall
be applied only to a Compound meeting any of the following criteria: (i) the
Compound is being actively developed; (ii) the Compound is commercially
sensitive to AZ; or (iii) the Compound is an isomer of a Compound described in
clause (i) or (ii). In marking with a development flag any Compound that is an
AZ Compound hereunder, AZ shall apply the same criteria in a manner consistent
with current internal policy and past practice as it does with other Compounds
under similar circumstances.

                  1.43.2   with respect to a CK Compound, a Compound that has
been designated as having restricted use within CK. Such restricted use applies
only to a Compound meeting any of the following criteria: (i) the Compound is
being actively developed; (ii) the Compound is commercially sensitive to CK; or
(iii) the Compound is an isomer of a Compound described in clause (i) or (ii).
In designating a Compound as having restricted use, CK shall apply the same
criteria in a manner consistent with current internal policy and past practice
as it does with other Compounds under similar circumstances.

         1.44     "PUBLIC" means (i) with respect to a Compound, such Compound
is not Proprietary, and (ii) with respect to AZ Compound Data or CK Compound
Data, such data is not Proprietary.

         1.45     "RESEARCH PLAN" means the document attached hereto as EXHIBIT
1.45 outlining the Research Program, the budget for the Research Program, and
each Parties' undertakings and obligations, including allocation of FTEs by CK
and AZ, in relation thereto.

         1.46     "RESEARCH PROGRAM" has the meaning described in Section 2.1
hereof.

         1.47     "RESEARCH TERM" means the period beginning on the Effective
Date and continuing for two (2) years thereafter, as may be extended in
accordance with Section 2.7 or by mutual written agreement of the Parties.

         1.48     "TERM" means the period beginning on the Effective Date and
continuing until the earlier of the date upon which this Agreement expires by
its terms, is terminated in accordance with Article VIII, or extended by mutual
written agreement of the Parties.

         1.49     "TECHNOLOGY" means any and all of the following, including
tangible copies and embodiments thereof:

                  1.49.1 information and materials (including Compounds)
relating to the subject matter of this Agreement and including data such as test
data (including pharmacological, toxicological and clinical test data) and image
data and in vitro and in vivo data;

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AZ AND CK CONFIDENTIAL

                  1.49.2 experimental methods and techniques, including those
that are part of or related to assays and cell cultures, screens, models,
practices, and know-how, techniques, trade secrets, and inventions (whether or
not patented or patentable);

                  1.49.3 instrumentation, including selection and arrangement of
instrumentation and setup or calibration settings;

                  1.49.4 computer software and code, and related technology,
including flow diagrams, designs, assemblers, applets, compilers, algorithms,
routines, design tools and user interfaces, in source code or object code form;
and

                  1.49.5 antibodies, markers, cells and cell lines;

         in each case (i) to the extent and for so long as such subject matter
or materials are not generally available in the public domain or otherwise from
a Third Party without restriction, except as a result of a Party's activities in
violation of the terms or conditions of this Agreement, or (ii) to the extent
and for so long as there are protectable Intellectual Property Rights subsisting
in or encompassing those materials.

         1.50 "THIRD PARTY" means any Person other than CK or AZ and the
Affiliates of either.

                         ARTICLE II - RESEARCH PROGRAM

         2.1 RESEARCH PROGRAM.

                  2.1.1    GENERALLY. CK and AZ agree to conduct a collaborative
research program with the specific goal of creating the Cytometrix(TM)
Hepatotoxicity Module for use in the Field as an in vitro predictor of
hepatotoxicity (the "RESEARCH PROGRAM"). The Research Program shall be conducted
solely in accordance with the Research Plan then in effect unless otherwise
mutually agreed in writing by the Parties or through the JRC in accordance with
Section 2.4.4.

                  2.1.2    DILIGENT EFFORTS. Each Party shall apply the same
diligent efforts with respect to the Research Program as each, respectively,
expends for its own high priority discovery technology programs. Without
limiting the foregoing, each Party shall apply diligent efforts toward the
performance of activities under the Research Program and allocate personnel and
other resources as reasonably necessary to successfully complete those
activities within the timeframes set forth in the Research Plan then in effect.

                  2.1.3    CONTRIBUTIONS. Each Party shall contribute to the
Research Program the items identified in Article III.

         2.2 CK FACILITIES AND CK PRINCIPAL SCIENTIST.

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AZ AND CK CONFIDENTIAL

                  2.2.1    CK shall provide the facilities, equipment, and
manpower that are reasonably necessary or useful to carry out the work
undertaken by CK under the Research Program at 280 East Grand Avenue, South San
Francisco, CA 94080 (the "CK FACILITY"). CK shall have the right to change the
location of the CK Facility upon reasonable advance written notice to AZ.

                  2.2.2    The principal scientist designated by CK (the "CK
PRINCIPAL SCIENTIST") shall be responsible for all Research Program activities
undertaken by CK and shall supervise the work of all personnel engaged by CK in
the Research Program. The CK Principal Scientist shall serve as the primary
contact for AZ on all matters related to the Research Program. The CK Principal
Scientist is [*]. CK may change the CK Principal Scientist, but only to a
similarly qualified individual and only on providing AZ with prior written
notice. Notwithstanding any change in the identity of the CK Principal
Scientist, CK shall continue to be responsible for performing the activities
undertaken by it under the Research Program and any consent or agreement by AZ
pursuant to this Section 2.2.2 shall not be deemed to be a waiver of any right
or remedy AZ may have in relation to any failure of CK to conduct such
activities.

         2.3 AZ FACILITIES AND AZ PRINCIPAL SCIENTIST.

                  2.3.1    AZ shall provide the facilities and equipment that
are reasonably necessary or useful to carry out the work undertaken by AZ under
the Research Program at [*] (the "AZ FACILITIES"). To the extent AZ is
authorized to use the Collaboration Technology or CK Background Technology at
more than one facility controlled by AZ, AZ shall designate in writing to CK
each such facility at which it is using the Collaboration Technology or CK
Background Technology. AZ shall provide prompt written updates of changes in the
location of any AZ Facility and AZ shall have the right to change the locations
of the AZ Facilities upon reasonable advance written notice to CK; provided that
after CK's delivery of the Cytometrix(TM) Hepatotoxicity Module such changes
shall only be effective upon CK's written approval.

                  2.3.2    The principal scientist designated by AZ (the "AZ
PRINCIPAL SCIENTIST") shall be responsible for all Research Program activities
undertaken by AZ and shall supervise the work of all personnel engaged by AZ in
the Research Program. The AZ Principal Scientist shall serve as the primary
contact for CK on all matters related to the Research Program. The AZ Principal
Scientist is [*]. AZ may change the AZ Principal Scientist, but only to a
similarly qualified individual and only on providing CK with prior written
notice. Notwithstanding any change in the identity of the AZ Principal
Scientist, AZ shall continue to be responsible for performing the activities
undertaken by it under the Research Program, and any consent or agreement by CK
pursuant to this Section 2.3.2 shall not be deemed to be a waiver of any right
or remedy CK may have in relation to any failure of AZ to conduct such
activities.

         2.4 THE JOINT RESEARCH COMMITTEE. Promptly after the Effective Date,
the Parties shall establish a Joint Research Committee (the "JRC") as set forth
in this Section 2.4. The JRC will

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AZ AND CK CONFIDENTIAL

exist until the end of the Pilot License Term. Each Party shall keep the JRC
informed of its progress and activities within the Research Program.

                  2.4.1    MEMBERSHIP. The JRC shall be comprised of an equal
number of representatives from each of AZ and CK, initially three (3) from each
of AZ and CK, including one lead representative from each Party (who may be but
is not required to be the CK Principal Scientist for CK and the AZ Principal
Scientist for AZ) and any ad hoc members as requested by either Party and
approved by the other Party in writing. For CK, the lead representative is [*];
for AZ, the lead representative is [*]. A Party may replace its lead
representative or other representatives to the JRC with other similarly
qualified individuals by providing advance written notice to the other Party.

                  2.4.2    MEETINGS. The JRC shall meet regularly during the
Research Term and the Pilot License Term, including face-to-face meetings to be
held at least quarterly, telephone or videoconference calls to be held at least
monthly, with additional regular e-mail and telephone exchanges among the
members. The JRC shall create and agree on written minutes for each meeting of
the JRC. The Parties shall alternate responsibility for chairing the meetings.
Each Party shall bear the expenses of its JRC members related to such members'
participation on the JRC and attendance at JRC meetings.

                  2.4.3    RESPONSIBILITIES.

                           (a) The JRC shall have responsibility for: (i)
reviewing and coordinating the Research Program, and for expediting work
progress under the Research Plan currently in effect; (ii) overseeing,
reviewing, recommending the direction of, and allocating resources under the
Research Program; (iii) preparing the Research Plan for each Contract Year
(other than Contract Year One); (iv) adapting and revising the Research Plan, if
appropriate; (v) approving any use of a Third Party's Technology or Intellectual
Property Rights in connection with the Research Program; (vi) tracking and
recording Compound Data provided under Section 3.2 or otherwise generated
pursuant to the Research Program; (vii) monitoring performance of the Research
Program, including comparing its progress to established goals and revising the
Performance Criteria as may be required or appropriate from time to time,
including to address removal of Proscribed Compounds or Proscribed Compounds
pursuant to Section 3.2.4 or 3.2.5; and (viii) carrying out other
responsibilities or making any other decisions as are expressly allocated to the
JRC under this Agreement.

                           (b) The Parties, through the JRC, shall discuss and
consider a proposal to expand the Research Program to include [*] activities
with respect to AZ Compounds and CK Compounds. Such discussions shall commence
no more than [*] months after the Effective Date. If such proposal is approved
by the Parties following the recommendation of the JRC, then the Research Plan
and this Agreement will be revised to reflect such expansion, which may include
modification of the Field to include [*]. If such expansion is not approved,
then the Parties, through the JRC, shall discuss and consider a proposal to
extend the licenses to AZ Compound Data and AZ Compounds to permit CK to conduct
[*] at its own expense outside the Research Program.

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AZ AND CK CONFIDENTIAL

                  2.4.4    DECISION MAKING. The JRC shall endeavor to reach
consensus on all matters brought before it. Decisions of the JRC must be made
with participation of at least two (2) representatives of each Party and by
unanimous vote of each participating representative. Decisions will be included
in the written minutes of a meeting, with such written minutes approved by all
Persons present at such a meeting of the JRC. In the event the JRC is unable to
resolve an outstanding matter, such matter shall be referred for resolution in
good faith by the Joint Steering Committee (JSC) as described in Section 2.5.

         2.5 THE JOINT STEERING COMMITTEE. Promptly after the Effective Date,
the Parties shall establish a Joint Steering Committee (the "JSC") as set forth
in this Section 2.5. The JSC will exist throughout the term of this Agreement.

                  2.5.1    MEMBERSHIP. The JSC shall be comprised of two (2)
representatives from each of AZ and CK. For AZ, the representatives are [*] and
[*]. For CK, the representatives are [*] and another individual to be selected
by CK by written notice to AZ. Each Party may replace its representatives on the
JSC at any time by providing written notice to the other Party. Replacements
must have comparable seniority, responsibility and knowledge or experience.

                  2.5.2    MEETINGS. The JSC shall meet at least once annually
during the Research Term, and as necessary from time to time during the
remainder of the Term, including face-to-face meetings, telephone or video
conference calls. The location and other logistics of any meeting will be
determined by the JSC. The JSC shall create and agree on written minutes for
each meeting of the JSC. Each party shall bear the expenses of its JSC members
related to such members' participation on the JSC and attendance at JSC
meetings.

                  2.5.3    RESPONSIBILITIES. The JSC shall have responsibility
to oversee and review the Research Program and to arbitrate decision making as
described below.

                  2.5.4    DECISION MAKING. Decisions of the JSC shall be made
by unanimous vote, with each Party having a single vote irrespective of the
number of representatives actually in attendance at a meeting. Decisions will be
included in the written minutes of a meeting, with such written minutes approved
by all persons present at such a meeting of the JSC. If the Parties are unable
to reach resolution within [*] days following the date the matter in dispute is
first brought to the attention of the JSC, that matter shall be resolved in
accordance with Section 10.2.

         2.6 RESEARCH PLAN.

                  2.6.1    INITIAL RESEARCH PLAN. The initial Research Plan,
which covers the Research Program during Contract Year One, is attached as
EXHIBIT 1.45. The Parties acknowledge and agree that such initial Research Plan
sets forth the goals and objectives of the Research Program and the broad terms
of the Parties' respective undertakings to achieve those goals and objectives.
The Parties further acknowledge and agree that the Research Plan will be
supplemented and otherwise amended by the JRC from time to time during the
Research Term

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for each stage of the Research Program to identify and define the specific
undertakings of the Parties required to implement the Research Program.

                  2.6.2    NEW RESEARCH PLANS. At least three (3) months prior
to the end of each Contract Year during the Research Term, the JRC shall meet to
establish the Research Plan for the upcoming Contract Year. The JRC shall
establish such Research Plan no later than thirty (30) days prior to the end of
the then-current Contract Year.

                  2.6.3    REVISED RESEARCH PLANS. In addition to new Research
Plans, the JRC shall review each Research Plan on an ongoing basis and may make
changes thereto in accordance with the procedures in Section 2.4.4.

                  2.6.4    REQUIREMENTS OF THE RESEARCH PLAN. Unless otherwise
agreed by each Party, the Research Plan must be consistent with the terms in
Article III and this Agreement generally.

         2.7 EXTENSION OF RESEARCH TERM. [*] days prior to the expiration of the
initial Research Term, the JRC shall discuss the possibility of extending the
Research Program and correspondingly the Research Term. In such event, if the
Parties do not reach agreement on an extension of the Research Term prior to the
expiration of the initial Research Term, then the expiration date for the
initial Research Team will be extended for [*] days, in order to continue
negotiation of the terms and conditions for an extension of the Research Term,
if any.

         2.8 INFORMATION AND REPORTS. During the Research Term, each Party shall
provide to the other, through the JRC, a written report summarizing the progress
of its activities and performance of the Research Program, and including data
and information pertaining to assays, protocols and procedures developed for use
with the Cytometrix(TM) Hepatotoxicity Module, and other information and
Technology as otherwise provided in the applicable Research Plan. Unless
otherwise agreed, such reports shall be due thirty (30) days after the end of
each calendar quarter and after the end of the Research Term. Upon the written
request of a Party, the other Party shall provide that requesting Party with raw
data generated by or on behalf of such other Party within the Collaboration
Technology and Collaboration Knowledge, to the extent not previously provided
hereunder. Without limiting the foregoing, each Party shall disclose to the
other Party, any and all Collaboration Technology and Collaboration Knowledge,
including any discoveries or inventions made by such Party in the scope of the
Research Program or pursuant to carrying out the Research Program, with
significant discoveries or advances being communicated as soon as practical
after such Collaboration Technology or Collaboration Knowledge is developed.

              ARTICLE III - CONTRIBUTIONS TO THE RESEARCH PROGRAM

         3.1 FTES. In its conduct of its activities under the Research Program
and unless otherwise mutually agreed in writing or determined by the JRC, each
Party shall assign the number of FTEs to the Research Program as follows: CK
shall commit [*] FTEs during each Contract Year to perform activities under the
Research Program in accordance with the

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Research Plan then in effect, and AZ shall commit [*] FTEs during the Research
Term to perform activities under the Research Program in accordance with the
Research Plan then in effect. For clarity, AZ has agreed to fund during each
Contract Year of the Research Term [*] of the FTEs committed by CK, as described
in Section 6.1.

         3.2 COMPOUNDS AND COMPOUND DATA.

                  3.2.1    AZ shall identify the AZ Compounds to be used in the
Research Program, and shall provide to CK the AZ Compounds in reasonable
quantities, but at least [*] for each AZ Compound. For each AZ Compound, AZ
shall provide the information, to the extent such information exists on the
Effective Date, contemplated by the version of EXHIBIT 1.4 attached to this
Agreement as of the Effective Date (which information, it is understood, may be
different for Proprietary and Public AZ Compounds). In addition to the
information on EXHIBIT 1.4, for each AZ Compound, AZ shall provide compound
purity and analytical and quality control data and procedures, to the extent
such information exists on the Effective Date. AZ is not required to provide [*]
for any Proprietary AZ Compounds. During the Research Term, AZ may include
additional Compounds as AZ Compounds upon written notice to CK or by mutual
written agreement of the Parties. For each such AZ Compound, AZ shall provide
the AZ Compound Data on EXHIBIT 1.4 and the other AZ Compound Data required
pursuant to this Section 3.2.1, to the extent such information exists at the
time such AZ Compound is added.

                  3.2.2    CK shall identify the CK Compounds to be used in the
Research Program, and make available for use in the Research Program, the CK
Compounds in reasonable quantities, but at least [*] for each CK Compound. For
each CK Compound, CK shall provide the information, to the extent such
information exists on the Effective Date, contemplated by the version of EXHIBIT
1.11 attached to this Agreement as of the Effective Date (which information, it
is understood, may be different for Proprietary and Public CK Compounds). In
addition to the information on EXHIBIT 1.11, for each CK Compound, CK shall
provide compound purity and analytical and quality control data and procedures,
to the extent such information exists on the Effective Date. CK is not required
to provide [*] for any Proprietary CK Compounds. During the Research Term, CK
may include additional Compounds as CK Compounds upon written notice to AZ or by
mutual written agreement of the Parties. For each such CK Compound, CK shall
provide the CK Compound Data on EXHIBIT 1.11 and other CK Compound Data required
pursuant to this Section 3.2.2, to the extent such information exists at the
time such CK Compound is added.

                  3.2.3    Each Party's rights with respect to the Compounds and
Compound Data delivered under this Agreement are as set forth in Section 5.3.

                  3.2.4    AZ may remove any Proprietary AZ Compound from use in
the Research Program, upon written notice to CK, if that Proprietary AZ Compound
becomes or is named a Proscribed Compound. EXHIBIT 1.4 shall be amended
accordingly and such Compound no longer shall be an "AZ Compound" for purposes
of this Agreement. Upon CK's receipt of notice that a Compound is a Proscribed
Compound and is being removed as an AZ Compound,

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CK shall, in AZ's sole discretion and at AZ's direction and expense, return or
destroy those removed Proscribed Compounds.

                  3.2.5    CK may remove a Proprietary CK Compound from use in
the Research Program, upon written notice to AZ, if that Proprietary CK Compound
becomes or is named a Proscribed Compound. EXHIBIT 1.11 shall be amended
accordingly and such Compounds no longer shall be "CK Compounds" for purposes of
this Agreement. Upon AZ's receipt of notice that a Compound is a Proscribed
Compound and is being removed as a CK Compound, AZ shall, in CK's sole
discretion and at CK's direction and expense, return or destroy those removed
Proscribed Compounds.

                  3.2.6    For clarity, nothing herein shall be deemed to create
an obligation on behalf of either Party to provide the other Party with
Compounds after the expiration of the Research Term, except that on an ongoing
basis after termination or expiration of the Research Term, AZ shall provide
Proprietary AZ Compounds to CK in specific amounts under the conditions
described in this Section 3.2.6 for the purpose of enabling CK to [*]. AZ shall
provide Proprietary AZ Compounds on the limited basis described herein in
accordance with the restrictions set forth in Section 3.2.7, Section 5.3 and
other reasonable and customary terms, provided the amount of payment for those
Proprietary AZ Compounds shall not exceed AZ's documented direct and reasonably
allocable indirect costs in obtaining such Compounds for any reason.

                  3.2.7    AZ's obligations under Section 3.2.6 shall extend for
no longer than [*] years after the date of expiration or termination of the
Research Term, but shall cease immediately upon termination of this Agreement
under Section 8.2.1 for CK's material breach or upon termination of this
Agreement under Section 8.2.3 for lack of feasibility.

                  3.2.8    AZ represents and warrants that no AZ Compound on
EXHIBIT 1.4 is, as of the Effective Date, a Proscribed Compound. CK represents
and warrants that no CK Compound on EXHIBIT 1.11 is, as of the Effective Date, a
Proscribed Compound.

         3.3 DELIVERABLES. CK shall deliver or otherwise make available to AZ
the Deliverables, as defined in EXHIBIT 1.23. The timing, form and manner of
delivery are set forth on the Research Plan, including which of the software
components of the Cytometrix(TM) Hepatotoxicity Module or other Deliverables
will be delivered in source code form and which in object code form. The
Research Plan also sets forth the infrastructure and instrumentation required
for use of the Cytometrix(TM) Hepatotoxicity Module, and objectives for
development, delivery and functionality of the Cytometrix(TM) Hepatotoxicity
Module, including parameters for expandability and flexibility.

         3.4 EVALUATION OF CYTOMETRIX(TM) HEPATOTOXICITY MODULE. After the
prototype Cytometrix(TM) Hepatotoxicity Module is installed at the CK Facility
and used in connection with CK's infrastructure and instrumentation, and then
again after the Cytometrix(TM) Hepatotoxicity Module is installed at the AZ
Facility and used in connection with AZ's infrastructure and instrumentation,
the Parties jointly shall perform mutually agreed testing and other evaluation

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procedures to determine whether the Cytometrix(TM) Hepatotoxicity Module meets
the Performance Criteria. If the Parties disagree as to whether the Performance
Criteria have been met, then the Parties shall cooperate to resolve any
disagreement. Where resolution is within the scope of the then-existing Research
Plan, the Parties shall cooperate to resolve the disagreement first under
Section 2.4 through the JRC, then under Section 2.5 through the JSC, and then
pursuant to Section 10.2. Where resolution is outside the scope of the
then-existing Research Plan, the Parties shall cooperate to resolve the
disagreement under Section 2.5 through the JSC, and then pursuant to Section
10.2.

                  3.5 TECHNOLOGY AND DELIVERY. AZ shall use diligent efforts to
make available for disclosure and delivery to CK, and CK shall use diligent
efforts to make available for disclosure and delivery to AZ, any and all
Technology that is (a) Controlled by the disclosing Party, (b) known to the
disclosing Party's personnel responsible for the Research Program or to
individuals that report to such personnel, and (c) is either reasonably required
or known to be useful to undertaking the activities under the Research Program
or performing the obligations required and activities contemplated under this
Agreement, whether such Technology arises out of Exempt Activities or otherwise
(such Technology, "RELEVANT TECHNOLOGY"). Relevant Technology includes AZ
Knowledge, CK Knowledge, AZ Background Technology and CK Background Technology.
Notwithstanding the foregoing, Relevant Technology shall exclude a Party's
Technology to the extent that disclosure of that Technology would materially
compromise an ongoing drug discovery or development program conducted by or on
behalf of that Party. Relevant Technology shall be disclosed in accordance with
this Section 3.5 below. Such disclosure shall occur within [*] months from the
time the disclosing Party's personnel responsible for the Research Program or
individuals that report to such personnel become aware of such Relevant
Technology.

                  3.5.1    If a disclosing Party deems Relevant Technology to be
AZ Background Technology or CK Background Technology, as applicable, then prior
to disclosing that Relevant Technology to the other Party hereunder, the
disclosing Party shall provide to the JRC a summary of that Relevant Technology,
in sufficient detail to determine whether that Relevant Technology is AZ
Background Technology or CK Background Technology, as applicable. The JRC will
confirm that such Relevant Technology is AZ Background Technology or CK
Background Technology; provided that it is not required to do so to the extent
the Relevant Technology consists of General Methods; and provided further and
notwithstanding the foregoing that the JRC is required to agree that Relevant
Technology is AZ Background Technology or CK Background Technology to the extent
it consists of a type of Technology already similar to that within CK Background
Technology or AZ Background Technology.

                  3.5.2    If the JRC confirms that Relevant Technology is AZ
Background Technology or CK Background Technology, as applicable, then the Party
to receive such Technology hereunder shall promptly notify the disclosing Party,
within [*] business days after confirmation by the JRC, if it does not wish
to receive such Relevant Technology; and provided further that AZ may not
decline to receive Relevant Technology to the extent that Relevant Technology is
reasonably necessary for the CHM to meet the Performance Criteria. The Parties
may agree that certain Technology should be disclosed in a different form or
manner


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(e.g., in object code rather than in source code), as appropriate. Exhibit 1.3
or Exhibit 1.10, as applicable, shall be amended to include such additional AZ
Background Technology or CK Background Technology.

                  3.5.3    If the JRC does not confirm such Relevant Technology
as AZ Background Technology or CK Background Technology and the receiving Party
has declined to receive such Relevant Technology, then the disclosing Party has
no obligation to disclose such Relevant Technology, and if the disclosing Party,
at its option, discloses such Technology, then it will be deemed AZ Knowledge or
CK Knowledge, as appropriate.

                      ARTICLE IV - EXCLUSIVITY OF EFFORTS

         4.1 EXCLUSIVITY OF EFFORTS. Except for the Exempt Activities, during
[*], neither AZ nor CK shall collaborate or otherwise cooperate with any Third
Party to, and neither AZ nor CK shall, perform research or development
specifically directed to the Field, other than under the Research Program. For
the avoidance of doubt, during [*], nothing herein shall restrict either Party
in any way from [*]. It is understood that even if the foregoing exclusivity
provision terminates or expires, each Party shall continue diligently to
endeavor to fulfill all of its obligations hereunder during the remainder of the
term of the Agreement, including those obligations directed at enabling the
Cytometrix(TM) Hepatotoxicity Module to meet the Performance Criteria.

         4.2 PERMITTED ACTIVITIES. Nothing herein shall be deemed to prevent or
restrict AZ's or CK's rights to undertake and perform the Exempt Activities and
CK's right to develop and commercialize the CM System for any and all
applications outside of the Field. Likewise, nothing herein shall be deemed to
prevent or restrict either Party's right to develop or commercialize methods of
or systems for in vitro prediction of hepatotoxicity when those methods or
systems are outside of the Field; provided that the Party is complying with its
obligations hereunder with respect to Confidential Information and Intellectual
Property Rights of the other Party.

                    ARTICLE V - OWNERSHIP AND LICENSE GRANTS

         5.1 OWNERSHIP.

                  5.1.1    AZ OWNERSHIP. AZ owns and shall own all right, title
and interest in and to the AZ Background Technology, AZ Compounds, AZ Compound
Data, AZ Knowledge and all Intellectual Property Rights therein. As between the
Parties, AZ has the exclusive right, at its sole discretion and expense, to
apply for, register, maintain and enforce Patents and other

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Intellectual Property Rights as it deems appropriate with respect to any of the
AZ Background Technology, AZ Compounds, AZ Compound Data and AZ Knowledge.

                  5.1.2    CK OWNERSHIP. CK owns and shall own all right, title
and interest in and to the CM System, CK Compounds, CK Compound Data, CK
Background Technology, CK Knowledge and all Intellectual Property Rights
therein. Further, CK owns and shall own all right, title and interest in and to
the Collaboration Technology and Collaboration Knowledge, and in and to the
Cytometrix(TM) Hepatotoxicity Module, and all Intellectual Property Rights
therein. Accordingly, AZ hereby assigns to CK any and all right, title and
interest in and to the Collaboration Technology, Collaboration Knowledge, and
the Cytometrix(TM) Hepatotoxicity Module, together in each case with all
Intellectual Property Rights therein that AZ may acquire as a result of its
performance of the Research Program or activities under the Pilot License (1)
except that AZ shall not assign those Improvements (and the Intellectual
Property Rights therein) owned by AZ pursuant to Section 5.1.3, and (2) the
foregoing assignment is subject to the licenses granted by CK to AZ under
Sections 5.4.2, 5.4.3, 5.5, 5.6 and 5.7. As between the Parties, CK has the
exclusive right, at its sole expense, to apply for, register, maintain and
enforce Patents and other Intellectual Property Rights as it deems appropriate
with respect to any of the CK Background Technology, CK Knowledge, CK Compounds,
CK Compound Data, Cytometrix(TM) Hepatotoxicity Module, Collaboration
Technology, Collaboration Knowledge and Improvements owned by CK under Section
5.1.3. AZ agrees to execute documents, render such reasonable assistance, and
take such other reasonable action at CK's expense as CK may reasonably request
to apply for, register, perfect, confirm, and protect the rights it assigns to
CK under this Section 5.1.2.

                  5.1.3    IMPROVEMENTS. Without limiting Section 5.1.2, (i) all
AZ Improvements are owned by AZ (subject to the licenses granted to CK under
Section 5.1.4), and (ii) all other Improvements to the Cytometrix(TM)
Hepatotoxicity Module arising during the Pilot License Term, whether created
jointly or solely by one of the Parties, are owned by CK. Accordingly, AZ hereby
assigns to CK any and all right, title and interest in and to any Improvements
owned by CK pursuant to this Section 5.1.3. AZ agrees to execute documents,
render such reasonable assistance, and take such other reasonable action at CK's
expense as CK may reasonably request to apply for, registered, perfect, confirm
and protect the rights it assigns to CK under this Section 5.1.3. After the end
of the Pilot License Term, Improvements to the Cytometrix(TM) Hepatotoxicity
Module made by CK shall be owned by CK and Improvements to the Cytometrix(TM)
Hepatotoxicity Module made by AZ shall be owned by AZ. For avoidance of doubt,
neither Party has any right, license or access to Improvements made by the other
Party after the end of the Pilot License Term.

                  5.1.4    LICENSE TO AZ IMPROVEMENTS. AZ agrees to grant and
hereby grants CK a worldwide, perpetual, irrevocable, non-exclusive right and
license, including the right to grant and authorize sublicenses, under AZ
Intellectual Property Rights in AZ Improvements.

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         5.2 LICENSES TO BACKGROUND TECHNOLOGY.

                  5.2.1    AZ GRANT TO CK. AZ agrees to grant and hereby grants
CK a non-exclusive, worldwide, royalty-free right and license, under AZ
Intellectual Property Rights in AZ Background Technology, to use AZ Background
Technology solely for the purposes of CK performing the Research Program during
the Research Term. Upon completion of the Research Program and CK delivering to
AZ the items required to be provided under the Research Plan, and upon the
Cytometrix(TM) Hepatotoxicity Module, as installed at the CK Facility, meeting
the Performance Criteria, AZ agrees to grant and hereby grants to CK a
non-exclusive, worldwide, royalty-free, perpetual right and license, limited to
the Field, under AZ Intellectual Property Rights in AZ Background Technology,
for CK to practice AZ Background Technology in the production, use and
modification of the Cytometrix(TM) Hepatotoxicity Module and Improvements
thereof. For [*] years following the expiration of the Research Term, CK's
license under this Section 5.2.1 shall be restricted solely for internal
research purposes, which internal research purposes include CK's use of the
Cytometrix(TM) Hepatotoxicity Module in its research collaborations with any
collaborator when required to advance the research collaboration or CK's
internal drug discovery and development programs; provided that the
Cytometrix(TM) Hepatotoxicity Module is not the predominant component of the
relationship between CK and such collaborator and provided further that in any
research collaboration the Cytometrix(TM) Hepatotoxicity Module is used for
activities such as to inform lead generation or to triage hits and leads rather
than solely for activities such as screening entire libraries of compounds. For
the avoidance of doubt however, such internal research use shall expressly
exclude exploitation of the Cytometrix(TM) Hepatotoxicity Module as a commercial
product or service (e.g., as a service bureau), except as expressly provided
above. In connection with such internal research purposes, CK may authorize
collaborators and others to access and use of the AZ Background Technology at
CK's facility. After the first [*] years after the Research Term, CK is free to
sublicense its rights under this Section 5.2.1 without restriction.

                  5.2.2    CK GRANT TO AZ. CK agrees to grant and hereby grants
AZ a non-exclusive, worldwide, royalty-free right and license, outside the
Prohibited Field and limited to the Field, under CK Intellectual Property Rights
in CK Background Technology, to use CK Background Technology solely for the
purposes of AZ performing the Research Program during the Research Term. To the
extent that CK Background Technology is software and is delivered to AZ in
object code form, AZ shall not reverse engineer or otherwise attempt to derive
source code from that software.

         5.3 LICENSES TO COMPOUNDS AND COMPOUND DATA.

                  5.3.1    AZ GRANT TO CK.

                           (a) AZ agrees to grant and hereby grants CK a
non-exclusive, worldwide, royalty-free license under AZ Intellectual Property
Rights in AZ Compounds and AZ Compound Data in the Field (a) during the Research
Term, solely in connection with CK's performance of the Research Program and in
accordance with the Research Plan, (b) during and after the Research Term, to
perform purity analysis, and (c) after the Research Term (1) for CK to

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[*] thereof, and (2) as expressly provided in Section 7.3. CK agrees that
although it may perform purity analysis as set forth above, neither it nor any
of its employees, agents or assigns shall [*], the AZ Compounds proprietary to
AZ without the prior written consent of AZ. For [*] years following the
expiration of the Research Term, CK's license under this Section 5.3.1 shall be
restricted solely for internal research purposes. For purposes of this
Agreement, internal research purposes include CK's use of the Cytometrix(TM)
Hepatotoxicity Module in its research collaborations with any collaborator when
required to advance the research collaboration or CK's internal drug discovery
and development programs; provided that the Cytometrix(TM) Hepatotoxicity Module
is not the predominant component of the relationship between CK and such
collaborator and provided further that in any research collaboration the
Cytometrix(TM) Hepatotoxicity Module is used for activities such as to inform
lead generation or to triage hits and leads rather than solely for activities
such as screening entire libraries of compounds. For the avoidance of doubt
however, such internal research use shall expressly exclude exploitation of the
Cytometrix(TM) Hepatotoxicity Module as a commercial product or service (e.g.,
as a service bureau), except as expressly provided above. In connection with
such internal research purposes, CK may authorize collaborators and others to
access and use of the AZ Compounds and Compound Data at CK's facility. After the
first [*] years after the Research Term, CK is free to sublicense its rights to
the AZ Compound Data for the purpose of [*] thereof under this Section 5.3.1(a).

                           (b) CK shall maintain written records regarding the
use of AZ Compounds and AZ Compound Data, and upon reasonable advance written
notice and during regular business hours, CK shall permit AZ or its authorized
designee to access CK Facilities, and to review required documentation to
determine compliance with the terms of this license.

                  5.3.2    CK GRANT TO AZ. CK agrees to grant and hereby grants
AZ a non-exclusive, worldwide, royalty-free license, but excluding all
activities in the Prohibited Field, under CK Intellectual Property Rights in CK
Compounds and CK Compound Data in the Field (a) during the Research Term, solely
in connection with AZ's performance of the Research Program and in accordance
with the Research Plan, (b) during and after the Research Term, to perform
purity analysis, and (c) after the Research Term (1) for AZ to [*] thereof, and
(2) as expressly provided in Section 7.3. AZ agrees that although it may perform
purity analysis as set forth above, neither it nor any of its employees, agents
or assigns shall [*], the CK Compounds proprietary to CK without the prior
written consent of CK.

                  5.3.3    PUBLIC COMPOUNDS AND PUBLIC COMPOUND DATA. The
Parties acknowledge that, with respect to any CK Compound or AZ Compound that is
designated as Public on EXHIBIT 1.11 or EXHIBIT 1.4 (as applicable) (together
with corresponding CK Compound Data or AZ Compound Data), nothing in this
Agreement will be construed to restrict either Party in any manner from using,
disclosing, reproducing, or obtaining from other sources such Compounds or such
data and information.

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         5.4 KNOWLEDGE LICENSES.

                  5.4.1    AZ KNOWLEDGE. AZ grants CK an automatic, worldwide,
non-exclusive, royalty-free, perpetual and irrevocable license to use, reproduce
and otherwise exploit AZ Knowledge. The license granted in this Section 5.4.1
includes the right to disclose such AZ Knowledge to, and authorize further
disclosure and use by, Third Parties in connection with ongoing discovery,
development, collaboration and marketing or other activities. Disclosure to
Third Parties must be under appropriate terms and conditions including
restrictions equivalent to any in this Section 5.4.1 and, to the extent any AZ
Knowledge also is AZ's Confidential Information, confidentiality provisions
substantially equivalent to those in this Agreement.

                  5.4.2    CK KNOWLEDGE. CK grants AZ an automatic, worldwide,
non-exclusive, royalty-free, perpetual and irrevocable license, to use,
reproduce and otherwise exploit CK Knowledge, solely for applications outside
the Prohibited Field. The license granted in this Section 5.4.2 includes the
right to disclose such CK Knowledge to, and authorize further disclosure use by,
Third Parties in connection with ongoing discovery, development, collaboration
and marketing or other activities. Disclosure to Third Parties must be under
appropriate terms and conditions including restrictions equivalent to any in
this Section 5.4.2 and, to the extent any CK Knowledge also is CK's Confidential
Information, confidentiality provisions substantially equivalent to those in
this Agreement.

                  5.4.3    COLLABORATION KNOWLEDGE. During and after the
Research Term, CK grants AZ an automatic, worldwide, non-exclusive,
royalty-free, perpetual and irrevocable license, to use, reproduce and otherwise
exploit Collaboration Knowledge, solely for applications outside the Prohibited
Field. The license granted in this Section 5.4.3 includes the right to disclose
such Collaboration Knowledge to, and authorize further disclosure use by, Third
Parties in connection with ongoing discovery, development, collaboration and
marketing or other activities by or on behalf of AZ. Disclosure to Third Parties
of Collaboration Knowledge licensed under this Section must be under appropriate
terms and conditions including restrictions equivalent to any in this Section
5.4.3 and, to the extent any such Collaboration Knowledge also is CK's
Confidential Information, confidentiality provisions substantially equivalent to
those in this Agreement.

         5.5 COLLABORATION TECHNOLOGY LICENSES.

                  5.5.1    CYTOMETRIX(TM) HEPATOTOXICITY MODULE MEETS
PERFORMANCE CRITERIA. Upon the Cytometrix(TM) Hepatotoxicity Module meeting the
Performance Criteria at the AZ Facility (as determined pursuant to Section 3.4),
CK agrees to grant and hereby grants to AZ a worldwide, perpetual,
non-transferable (except in accordance with Section 10.4), non-exclusive right
and license, outside the Prohibited Field, under CK Intellectual Property Rights
in Collaboration Technology. The rights granted in this Section 5.5.1 do not
extend to the use, development or exploitation of Collaboration Technology in
the Field, which restriction is for a period not to exceed [*] years following
the Pilot License Term (subject to earlier termination of the foregoing
restriction pursuant to Section 8.3.2(b) for termination of the Agreement under
Section 8.2.1).

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                  5.5.2    OPTION FOR LICENSES WHEN CYTOMETRIX(TM)
HEPATOTOXICITY MODULE FAILS TO MEET PERFORMANCE CRITERIA OR AGREEMENT IS
TERMINATED PURSUANT TO SECTION 8.2.3. If either (1) the Parties determine that
the Cytometrix(TM) Hepatotoxicity Module has not met the Performance Criteria
(as determined pursuant to Section 3.4) or (2) this Agreement is terminated
prior to the end of the Pilot License Term pursuant to Section 8.2.3 (Lack of
Feasibility), then AZ may, at its option, obtain a license to Collaboration
Technology as set forth in this Section 5.5.2. Upon the occurrence of either of
the conditions outlined above, AZ may provide notice to CK of its desire to
obtain such a license, and the Parties will negotiate in good faith an amount to
be paid for the license, but not to exceed US$[*]. Upon payment of such
amount, CK agrees to grant and hereby grants to AZ a worldwide, perpetual,
non-exclusive, non-transferable (except in accordance with Section 10.4),
irrevocable right and license under CK Intellectual Property Rights in
Collaboration Technology, solely for applications outside the Prohibited Field.

         5.6 PILOT LICENSE AND SUPPORT.

                  5.6.1    PILOT LICENSE. Upon the Cytometrix(TM) Hepatotoxicity
Module meeting the Performance Criteria at the CK Facility, CK agrees TO grant
and hereby grants AZ, during the Pilot License Term, a worldwide, non-exclusive,
non-transferable (except in accordance with Section 10.4), royalty-free right
and license in the Field (but excluding all activities or applications in the
Prohibited Field), under CK Intellectual Property Rights in CK Knowledge, CK
Background Technology and Collaboration Technology, to use the Cytometrix(TM)
Hepatotoxicity Module, together with any Improvements owned by CK, solely for
its own internal research at the AZ Facility (the "PILOT LICENSE"). To the
extent that a software component of the Cytometrix(TM) Hepatotoxicity Module is
delivered in object code form, the license granted extends only to the object
code form and not the source code form of that software, and AZ shall not, and
shall not permit any Third Party to, reverse engineer or decompile, or otherwise
attempt to derive source code from that software component. To the extent that a
software component of the prototype version of the Cytometrix(TM) Hepatotoxicity
Module is delivered in source code form, AZ shall not modify that software
component and the use and disclosure thereof is subject to the requirements of
Section 7.1; however, it is understood that AZ may compile such source code to
create the object code derivative thereof.

                  5.6.2    SUPPORT. CK shall provide technical support as set
forth on EXHIBIT 5.6.2 with respect to the Cytometrix(TM) Hepatotoxicity Module.
For clarity, CK has no support obligations other than as expressly set forth on
that EXHIBIT 5.6.2.

         5.7 AZ FULL LICENSE TO CYTOMETRIX(TM) HEPATOTOXICITY MODULE.

                  5.7.1    LICENSES. Upon the Cytometrix(TM) Hepatotoxicity
Module meeting the Performance Criteria at the AZ Facility, and upon payment by
AZ of the Milestone Payment under Section 6.2 and the Annual License Renewal
Fees thereafter, CK agrees to grant and hereby grants AZ, during the Full
License Term, a worldwide, non-exclusive, non-transferable (except in accordance
with Section 10.4), royalty-free right and license in the Field (but excluding
all activities or applications in the Prohibited Field), under CK Intellectual
Property

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Rights in CK Knowledge, CK Background Technology and Collaboration Technology,
(i) to use the Cytometrix(TM) Hepatotoxicity Module, and any Improvements (to
the extent such Improvements are in the Field, owned by CK, and in existence as
of the first day of the Full License Term), for its own internal research and
development program at any and all AZ Facilities, (ii) to make and distribute a
reasonable number of copies of the Cytometrix(TM) Hepatotoxicity Module,
including a reasonable number of backup copies thereof in connection with the
exercise of the rights set forth in clause (i) above, and (iii) to create
derivative works of the Cytometrix(TM) Hepatotoxicity Module only for the
purpose of maintaining and supporting AZ's authorized use thereof and to the
extent those derivative works are within the scope of the Deliverables described
in EXHIBIT 1.23 and of the following activities: refining the model by including
extra compounds, modifying existing assays, and incorporating additional assays
(the foregoing licenses in clauses (i) through (iii) above together are the
"FULL LICENSE"). To the extent that a software component of the Cytometrix(TM)
Hepatotoxicity Module is delivered in object code form, the license granted
extends only to the object code form and not the source code form of that
software, and AZ shall not, or permit any Third Party to, reverse engineer or
decompile, or otherwise attempt to derive source code from that software
component.

                  5.7.2    RECORDS. AZ shall maintain records regarding the use
of the Cytometrix(TM) Hepatotoxicity Module, and upon reasonable advance written
notice and during regular business hours, AZ shall permit CK or its authorized
designee to access AZ Facilities, and to review required documentation to
determine compliance with the terms of this license.

         5.8 NO IMPLIED LICENSES. Each Party acknowledges that the rights and
licenses granted under this Article V are limited to the scope expressly granted
herein, and all rights not so granted are hereby expressly reserved. Nothing in
this Agreement shall limit in any respect the right of either Party to use its
own Technology to conduct research and development with respect to and
commercialize products or technologies outside the Field. Consistent with the
foregoing, it is understood that licenses to Collaboration Technology and
licenses to Collaboration Knowledge do not include or incorporate any right or
license to CK Background Technology; exploitation of Collaboration Technology or
Collaboration Knowledge may require a license to the underlying subject matter.
It is further understood that licenses to Collaboration Technology and licenses
to Collaboration Knowledge do not extend to the Cytometrix(TM) Hepatotoxicity
Module; exploitation of Collaboration Technology or Collaboration Knowledge that
is not independent of the Cytometrix(TM) Hepatotoxicity Module may require a
separate license to such Cytometrix(TM) Hepatotoxicity Module for use thereof.

                             ARTICLE VI - PAYMENTS

         6.1 RESEARCH PROGRAM FUNDING.

                  6.1.1    FTE FUNDING. Each Party shall assume responsibility
for its own costs and expenses for its conduct of activities under the Research
Program with the sole exception that AZ shall fund, quarterly in advance, during
the Research Term (whether or not the Pilot License Term has begun), [*] of the
[*] FTEs to be committed by CK for the performance of the Research Program, at
the FTE rate set forth below. In total, subject to any

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Additional Items, the annual FTE funding to be provided by AZ to CK under this
Section 6.1.1 shall not exceed US$[*], unless otherwise separately agreed by the
Parties in writing.

                  6.1.2    The FTE rate is [*] dollars (US$[*]) per year, which
includes all employee-related compensation, including salaries, wages, bonuses,
benefits, profit sharing, stock option grants, and FICA costs, travel, meals and
entertainment (except in connection with reimbursed travel described below),
training, recruiting, relocation, operating supplies, postage, communications
expense, professional dues, depreciation, repairs and maintenance, rent and
lease, utilities, taxes, facilities and space costs, and computer service
charges. The FTE rate excludes the cost of items identified as Additional Items
as described in Section 6.1.2. AZ shall have no obligation to fund FTEs after
the Research Term. During the Pilot License Term, the direct out-of-pocket
expenses of travel and lodging incurred by CK personnel while required to be on
site pursuant to the Research Program will be reimbursed by AZ to CK; provided
that the CK employees are away from the facility at which those personnel
typically work and the duration of the trip is for an extended period of time
(i.e., more than three (3) working days). AZ shall reimburse CK for such direct
out-of-pocket expenses incurred by CK that are within the AZ travel guidelines
within sixty (60) days after receipt by AZ of a correct invoice with supporting
documentation from CK that identifies the name of the employee, the date of the
trip(s) taken and the total dollar amount incurred with sufficient detail to
determine amounts incurred for transportation, meals, lodging, and related
incidentals.

                  6.1.3    ADDITIONAL EXPENSES. From time to time, the JRC may
identify additional items or subject matter required to carry out the Research
Program, including additional licenses under Intellectual Property Rights of
Third Parties, extraordinary equipment or specialized reagents or any other
external costs (each such item an "ADDITIONAL ITEM"). In each instance, the JRC
will apportion the cost of Additional Items according to the following
principles: (i) if the Additional Item will be consumed fully during the
Research Term and will be used only for work in the Field, the expense will be
borne equally by CK and AZ; (ii) if the Additional Item will not be fully
consumed during the Research Term, or will be used during the Research Term
outside the Field by either CK or AZ, the expense will be apportioned between CK
and AZ in a manner that equitably reflects the relative value to the Research
Program of such Additional Item and for applications outside of the Research
Program for the Party(ies) that will have rights thereto. For clarity, neither
Party shall have any obligation to reimburse the other Party with respect to
amounts incurred by the other Party with respect to any Additional Item, except
as agreed by the JRC. Unless otherwise mutually agreed, during the Research
Program, CK shall be the contracting Party with respect to any such Additional
Items and shall directly pay for any such Additional Items. If there are cost
apportionment concerns regarding Additional Items during the Pilot Program,
responsibility for such costs shall be resolved by the JRC. All equipment
acquired during the Pilot Phase at the AZ facility shall become the property of
AZ.

         6.2 MILESTONE PAYMENT. Upon completion of the Research Program, after
CK has delivered to AZ the items required to be provided under the Research
Plan, and upon the Cytometrix(TM) Hepatotoxicity Module, as installed at the AZ
Facility, meeting the Performance Criteria (as determined pursuant to Section
3.4), a milestone payment of [*] USD dollars


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(US$[*]) ("MILESTONE PAYMENT") will become due and payable. AZ shall pay the
Milestone Payment within thirty (30) days following receipt of an invoice from
CK, generated in accordance with the foregoing.

         6.3 LICENSE RENEWAL FEES.

                  6.3.1    On each of the first [*] annual year anniversaries of
the date on which the Full License is first effective, AZ shall pay to CK an
annual license renewal fee of [*] dollars (US$[*]) ("ANNUAL LICENSE RENEWAL
FEE") for continuance of the Full License, within thirty (30) days after CK's
invoice. On each of the [*] through [*] annual year anniversaries of the date on
which the Full License is first effective, AZ has the option to (i) pay to CK
the annual license renewal fee of [*] dollars (US$[*]) for continuance of the
Full License, within thirty (30) days after CK's invoice or the end of a
Contract Year, or (ii) cease payments and terminate the Full License. Upon
either (i) a CK Change of Control event that arises due to CK's merger with,
acquisition by, or other similar transaction with a pharmaceutical company with
annual sales in excess of US$1 billion that occurs at any time during the Full
License, or (ii) payment of the [*] such annual license renewal fee in
accordance with this Agreement, the Full License granted to AZ pursuant to
Section 5.7 shall become fully paid up and perpetual.

                  6.3.2    To the extent CK licenses the use of the
Cytometrix(TM) Hepatotoxicity Module to any Third Party for an amount that is
leSS than the amount owed by AZ under Section 6.3.1, AZ's obligation to pay to
CK an Annual License Renewal Fee of US$[*] shall be reduced to the equivalent or
less than the lowest amount that such Third Party is obligated to pay.

         6.4 TAXES. CK will be responsible for paying any and all taxes and
assessments relating to any income or other consideration that CK derives from
this Agreement. All payments made by AZ to CK under this Agreement shall be made
without any deduction or withholding for or on account of any taxes. Withholding
taxes, if any, must be paid by AZ to the relevant taxing authority on behalf of
CK.

         6.5 TOTAL OBLIGATION. The Annual License Renewal Fees and the Milestone
Payment payable by AZ to CK pursuant to this Agreement, taken together with the
funding to be provided by AZ to CK and other amounts payable pursuant to this
Article 6, represent all of AZ's financial obligations to CK hereunder. CK shall
not be entitled to any additional compensation or remuneration from AZ under
this Agreement. The foregoing will not be construed as a limit on fees due for
termination, damages for breach, or obligations of indemnity.

                         ARTICLE VII - CONFIDENTIALITY

         7.1 CONFIDENTIAL INFORMATION.  Except to the extent expressly
authorized by this Agreement or otherwise  agreed in writing,  the Parties agree
that, for ten (10) years after the expiration of the Research Term, the
receiving  Party shall keep  confidential  and shall not publish or  otherwise
disclose or use for any purpose  other  than  as  provided  for  in  this
Agreement  any   Confidential Information of the other Party. "CONFIDENTIAL
INFORMATION" means (i) any

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AZ AND CK CONFIDENTIAL

prototypes provided by CK under this Agreement or in connection with the
Research Program; (ii) information disclosed in tangible form that is marked
"confidential" or with other similar designation to indicate its confidential or
proprietary nature; and (iii) information disclosed orally, where such
information is either (A) of the type usually considered confidential or
proprietary in the biopharmaceutical industry or (B) otherwise indicated to be
confidential or proprietary by the disclosing Party at the time of the initial
disclosure thereof and confirmed in writing as confidential or proprietary by
the disclosing Party within thirty (30) days after such disclosure.
Notwithstanding the foregoing, Confidential Information shall not include
information that, in each case as demonstrated by written documentation:

                           (a) was already or becomes lawfully known to the
receiving Party, other than under an obligation of confidentiality, at the time
of disclosure;

                           (b) can be demonstrated by documentation or other
competent proof to have been in the receiving Party's or its Affiliates'
possession prior to disclosure by the disclosing Party;

                           (c) is subsequently received by the receiving Party
or its Affiliates from a Third Party who is not bound by any obligation of
confidentiality with respect to that information;

                           (d) is generally made available to Third Parties by
the disclosing Party without restriction on disclosure;

                           (e) was generally available to the public or
otherwise part of the public domain at the time of its disclosure to the
receiving Party or became generally available to the public or otherwise part of
the public domain after its disclosure and other than through any act or
omission of the receiving Party in breach of this Agreement; or

                           (f) was developed by the receiving Party without
reference to any information or materials disclosed or provided by the
disclosing Party.

         7.2 PERMITTED DISCLOSURES. Notwithstanding Section 7.1 above, each
Party may disclose Confidential Information of the other Party as follows:

                           (a) to Third Parties (and to Affiliates) under
appropriate terms and conditions including confidentiality provisions
substantially equivalent to those in this Agreement in connection with obtaining
financing and other business activities, such Confidential Information permitted
under this subsection to be disclosed shall be limited to general descriptions
of the activities, technology and findings under this Agreement (including
associations), and shall exclude hepatotoxicity profiles, other than
toxicophoric centers, associated with chemotypes;

                           (b) as is reasonably necessary to exercise the rights
and licenses granted or reserved herein (including the right to grant
sublicenses);

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AZ AND CK CONFIDENTIAL

                           (c) to the extent such disclosure is reasonably
necessary in filing for, registering or maintaining Intellectual Property Rights
in accordance with Section 5.1;

                           (d) as required by law or regulation (including
applicable securities regulations); provided, however, that if a Party is
required by law or regulation to make any such disclosure of the other Party's
Confidential Information it will, except where impracticable for necessary
disclosures, give reasonable advance notice to the other Party of such
disclosure requirement will use its reasonable efforts to secure confidential
treatment of such Confidential Information required to be disclosed; or

                           (e) to the extent mutually agreed to by the Parties.

         7.3 RESTRICTIONS ON DISCLOSURE OF DATA SETS. Notwithstanding anything
to the contrary in this Agreement, AZ agrees that it shall treat as CK's
Confidential Information data sets generated by AZ using the CK Compounds.
Likewise, CK agrees that it shall treat as AZ's Confidential Information data
sets generated by CK using the AZ Compounds. However, CK may disclose those data
sets to CK collaborator(s) under appropriate obligations of confidentiality no
less protective than those for CK's own information. In addition, either Party
may use and disclose such data sets without restriction (a) as aggregated
information and data sets, whether about the proprietary or public AZ Compounds
or CK Compounds, as applicable for purposes of describing the utility of the
Cytometrix(TM) Hepatotoxicity Module and the general nature of the activities
under this Agreement; and (b) individual data sets about public AZ Compounds or
CK Compounds, as applicable, in each case so long as that Party does not
disclose specific [*], other than [*], that could be associated with specific
[*].

         7.4 PRESS RELEASE; CONFIDENTIALITY OF TERMS OF AGREEMENT. Neither Party
shall disclose to any Third Party the terms of this Agreement without the prior
written consent of the other Party, except (a) to advisors and existing and
potential investors on a need to know basis under circumstances that reasonably
ensure the confidentiality thereof, (b) to Third Parties to the extent necessary
to comply with the terms of licenses from Third Parties with respect to a
Party's Confidential Information, (c) to the extent required by law or a court
or other governmental body; provided that in such situation the Party wishing to
disclose the terms gives reasonable advance written notice to the non-disclosing
Party of the proposed disclosure and the reason for such disclosure and uses
reasonable efforts to secure confidential treatment of such disclosed
information. Notwithstanding the foregoing, following the Effective Date, the
Parties shall issue a press release, substantially in the form of EXHIBIT 7.4,
to announce the execution of this Agreement, together with a corresponding
Question & Answer outline for use that has been approved in advance by both
Parties for the purpose of responding to inquiries about the Agreement;
thereafter, each of AZ and CK may each disclose to Third Parties the information
contained in such press release and Question & Answer outline without the need
for further approval by the other. In addition, with the advance review and
prior written approval of the other Party in each instance, each Party is
authorized to issue additional press releases when amounts such as milestone
payments or licensing fees become due under this Agreement.

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         7.5 PUBLICATION. Each Party acknowledges the other Party's interest in
publishing the results of the Research Program, obtaining valid patent
protection, and protecting business interests and trade secrets. Consequently,
if (i) CK, its employees, agents or consultants wish to make a publication
related to the CK Compounds or the AZ Compounds (it is understood that CK will
not disclose the identity of the AZ Compounds or other Confidential Information
of AZ without AZ's prior written consent), or (ii) AZ, its employees, agents or
consultants wish to make a publication regarding the use of the Cytometrix(TM)
Hepatotoxicity Module or CM System in any manner, with or without the CK
Compounds (it is understood that AZ will not disclose Confidential Information
of CK without CK's prior written consent), in each case, such Party shall
deliver to the other Party a copy of the proposed written publication or an
outline of an oral disclosure at least thirty (30) days prior to submission for
publication or presentation. The reviewing Party may (a) propose modifications
to the publication for patent reasons or business reasons, (b) delete any trade
secrets or Confidential Information of such Party included in that publication,
or (c) request a reasonable delay in publication or presentation to protect
know-how and patentable subject matter. Once a particular public disclosure has
been approved, either Party may disclose the information contained therein in
subsequent disclosures.

         7.6 OUTSOURCING OF IT TECHNOLOGY SERVICES.

                  7.6.1    RIGHT TO OUTSOURCE. Without limiting the foregoing
confidentiality provisions, during the Pilot License Term and the Full License
Term, AZ shall have the right to appoint a Third Party ("OUTSOURCER") to provide
information technology "outsourcing" services to AZ and its Affiliates that
relates to the subject matter of this Agreement ("OUTSOURCE SERVICES") for the
purposes of enabling AZ to perform under the Agreement or enabling AZ to use
Technology and or information licensed under this Agreement, only on behalf of
AZ and for the purposes permitted under this Agreement. Outsource Services
include loading any software licensed under the Agreement onto equipment owned
or controlled by the Outsourcer, located either at the AZ Facility, an
Outsourcer's premises or at the CK Facility. In connection with an Outsourcer
providing Outsource Services, CK shall permit the Outsourcer to access, operate
and use such software on its equipment in its performance of the Outsource
Services, and shall otherwise permit the Outsourcer, in its performance of the
Outsource Services, to do anything that AZ or its Affiliates are not precluded
from doing under the Agreement that are reasonably connected to the Outsource
Services, such as accessing, operating and using items supplied or licensed
under the Agreement, and receiving and using services provided under the
Agreement.

                  7.6.2    COOPERATION WITH OUTSOURCER. AZ shall provide to CK a
copy of its agreement with any Outsourcer, to the extent relevant to either
Party's activities, rights or obligations under this Agreement. CK shall
reasonably cooperate with any authorized Outsourcer in the Outsourcer's
performance of the Outsource Services. In order to provide Outsource Services to
AZ under this Agreement, it may be necessary for Outsourcer to have access to CK
Confidential Information. Outsourcer shall be bound by terms of confidentiality
no less restrictive than those contained in this Agreement as applied to AZ.

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                       ARTICLE VIII- TERM AND TERMINATION

         8.1 TERM; EXPIRATION. This Agreement will commence upon the Effective
Date and unless terminated as provided in this Article VIII shall continue in
full force and effect until [*] months following payment by AZ of the [*] Annual
License Renewal Fee pursuant to Section 6.3.

         8.2 EARLY TERMINATION.

                  8.2.1    MATERIAL BREACH. At any time during the Term, if a
Party materially breaches this Agreement and does not cure that material breach
within thirty (30) days after written notice from the non-breaching Party, then
upon further written notice the non-breaching Party may terminate this
Agreement. If within thirty (30) days following notice of breach from the
non-breaching Party, the Party allegedly in breach initiates a dispute
resolution procedure in good faith and as permitted under this Agreement for
resolution of the dispute for which termination is being sought and is
diligently pursuing such procedure (including any litigation or arbitration
following therefrom), then termination is effective only if at the conclusion of
the dispute resolution procedure, the initiating Party notifies the other Party
in writing that the termination shall take effect. The non-breaching Party may,
however, withhold or suspend performance of its obligations during the pendency
of such dispute resolution procedure, without being considered to be in breach
of its obligations hereunder, and without liability for having so withheld or
suspended performance. Notwithstanding anything to the contrary in this Section
8.2.1, however, if the breach is a failure to pay amounts due under Sections 6.2
or 6.3, then the licenses granted to AZ by CK shall not continue during pendency
of the dispute.

                  8.2.2    [INTENTIONALLY LEFT BLANK.]

                  8.2.3    MUTUALLY FOR LACK OF FEASIBILITY. If the Parties
mutually determine that installing and implementing the Cytometrix(TM)
Hepatotoxicity Module in a manner that meets the Performance Criteria is not
scientifically or commercially feasible, or if the Parties mutually determine,
after installing the Cytometrix(TM) Hepatotoxicity Module at the AZ Facility,
that it has material deficiencies that cannot reasonably be remedied, then by
mutual written agreement the Parties may terminate this Agreement.

                  8.2.4    BY AZ FOR ITS CONVENIENCE DURING LATER FULL LICENSE
TERM. During the [*] through [*] years of the Full License Term and not before,
and provided that AZ is in compliance with its obligations under this Agreement
and has paid all amounts previously due, for any reason or no reason, AZ may
terminate this Agreement by providing written notice of non-renewal at least
thirty (30) days prior to the date on which the annual renewal license fee would
be due.

                  8.2.5    BY AZ FOR ITS CONVENIENCE PRIOR TO [*] YEAR OF THE
FULL LICENSE TERM. At any time after the Research Term and prior to the [*] year
of the Full License Term, for any reason or for no reason, AZ may terminate this
Agreement by providing written notice at least ninety (90) days prior to such
termination.

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                  8.2.6    BY EITHER PARTY FOR INSOLVENCY. At any time during
the Term, if either Party is subject to an Insolvency Event (defined below),
then the other Party may terminate this Agreement upon thirty (30) days prior
written notice to the other Party. For purposes of the foregoing, an "Insolvency
Event" is any of the following: (i) making a general assignment for the benefit
of creditors; (ii) filing an insolvency petition in bankruptcy (other than a
petition for reorganization); (iii) petitioning for or acquiesces in the
appointment of any receiver, trustee or similar officer to liquidate or conserve
its business or any substantial part of its assets; (iv) commencing under the
laws of any jurisdiction any proceeding involving its dissolution or liquidation
or any other similar proceeding; (v) ceasing to carry on the whole or
substantially the whole of its business or that part of its business to which
this Agreement relates; or (vi) becoming a party to any proceeding or action of
the type described above in (iii) or (iv) and such proceeding or action remains
undismissed or unstayed for a period of sixty (60) days.

         8.3 CONSEQUENCES OF EXPIRATION OR TERMINATION.

                  8.3.1    SURVIVAL. In all events of expiration or termination
the provisions of Articles I (Definitions), VII (Confidentiality), and X
(Miscellaneous), and Sections 2.8(Information and Reports), 4.2 (Permitted
Activities), 5.1 (Ownership) (including 5.1.4 (License to AZ Improvements), 5.4
(Knowledge Licenses), 5.7.2 (Record Keeping), 5.8 (No Implied Licenses), 6.4
(Taxes), 8.3 (Consequences of Expiration or Termination), 9.2 (Warranty
Disclaimer) and 9.3 (No Liability) shall survive. In addition, the Full License
under Section 5.7 survives in any event if it has become fully paid-up pursuant
to the last sentence of Section 6.3 (License Renewal Fee).

                  8.3.2    OTHER CONSEQUENCES. The following are in addition to
any Sections that survive under Section 8.3.1. Sections or rights not noted as
surviving terminate on termination of the Agreement. In each case, on
termination each Party promptly shall return to the other Party any Technology
or Confidential Information of the other Party, except to the extent the
licenses granted pursuant to this Agreement to such Technology or Confidential
Information survive.

                           (a) In the event of expiration pursuant to Section
8.1 (Term; Expiration), Section 3.2.6 and Section 3.2.7 (Compounds) survive for
the period indicated therein, licenses to Background Technology (Section 5.2)
and Compounds and Compound Data (Section 5.3) survive, all licenses to
Collaboration Technology under Section 5.5.1 survive, CK may retain the physical
AZ Compounds and AZ Compound Data in its possession, and each Party shall retain
identical copies of the images and derived data generated during the Research
Term.

                           (b) In the event of termination by AZ under Section
8.2.1 (Material Breach by CK): (i) AZ has no further requirement to pay FTE
costs, the Milestone Payment, the Annual License Renewal Fees or any other
amounts not already due and owing; (ii) the licenses from CK to AZ for CK
Background Technology (Section 5.2) and CK Compounds and CK Compound Data
(Section 5.3) survive and AZ may retain the physical CK Compounds and CK
Compound Data in its possession; (iii) CK shall return to AZ all AZ Compounds in
its possession, and, for avoidance of doubt, AZ has no obligation to provide AZ
Compounds under

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Section 3.2.6; (iv) the license from CK to AZ for Collaboration Technology
(under either Section 5.5.1 or Section 5.5.2, as appropriate) survive; (v) where
such termination occurs prior to the end of the Pilot License Term, CK will be
deemed to have granted a license to the components or portions of the
Cytometrix(TM) Hepatotoxicity Module installed at AZ Facilities, on the same
terms as Section 5.7, but without payment of further fees; (vi) where such
termination occurs during the Full License Term, the license granted to the
Cytometrix(TM) Hepatotoxicity Module to AZ continues in accordance with its
terms without additional payment of fees; (vii) CK shall deliver to AZ all
images and derived data generated during the Research Term in its possession;
and (viii) the restriction under the last sentence of Section 5.5.1 no longer
applies.

                           (c) In the event of termination by CK under Section
8.2.1 (Material Breach by AZ): (i) AZ shall pay, in each case to the extent not
yet paid, any remaining FTE costs, the Milestone Payment, and the unpaid balance
of the first [*] Annual License Renewal Fees; (ii) the licenses from AZ to CK
for AZ Background Technology (Section 5.2) and AZ Compounds and AZ Compound Data
(Section 5.3) survive and CK may retain the physical AZ Compounds and AZ
Compound Data in its possession; (iii) AZ's obligation to provide Proprietary AZ
Compounds under Section 3.2.6 and Section 3.2.7 continues for the time
indicated, regardless of whether or not the Research Term has been completed;
(iv) in the event that such termination occurs prior to the end of the Research
Term, AZ's obligations with respect to exclusivity of efforts (Section 4.1)
continue for an additional [*] month period; and (v) AZ shall deliver to CK all
images and derived data generated during the Research Term in its possession.

                           (d) [INTENTIONALLY LEFT BLANK.]

                           (e) In the event of termination under Section 8.2.3
(Mutually for Lack of Feasibility): (i) AZ shall pay remaining unpaid FTE costs
(if any); (ii) the licenses from AZ to CK for AZ Background Technology (Section
5.2), and AZ Compounds and AZ Compound Data (Section 5.3) survive and CK may
retain the physical AZ Compounds and AZ Compound Data in its possession; (iii)
the license from CK to AZ for Collaboration Technology (under either Section
5.5.1 or Section 5.5.2, as appropriate) survive; (iv) the Cytometrix(TM)
Hepatotoxicity Module (including backups thereof) shall be removed from any AZ
Facilities in which it has been installed, and all licenses granted to AZ
thereunder shall terminate; and (v) each Party shall retain identical copies of
the images and derived data generated during the Research Term.

                           (f) In the event of termination or non-renewal by AZ
under Section 8.2.4 (AZ Convenience During Later Full License Term): (i) the
license from CK to AZ for Collaboration Technology under Section 5.5.1 survives;
(ii) the licenses from AZ to CK for AZ Background Technology (Section 5.2) and
AZ Compounds and AZ Compound Data (Section 5.3) survive, and CK may retain the
physical AZ Compounds and AZ Compound Data in its possession; and (iii) the
Cytometrix(TM) Hepatotoxicity Module (including backups thereof) shall be
removed from any AZ Facilities in which it has been installed, and all licenses
granted to AZ thereunder shall terminate; and (v) each Party shall retain
identical copies of the images and derived data generated during the Research
Term.

* Certain information on this page has been omitted and filed separately with
  the Commission. Confidential treatment has been requested with respect to the
  omitted portions.


                                      -30-

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AZ AND CK CONFIDENTIAL

                           (g) In the event of termination or non-renewal by AZ
under Section 8.2.5 (AZ Convenience Prior to [*] Year of the Full License
Term): (i) AZ shall pay, in each case to the extent not yet paid, any remaining
FTE costs, the Milestone Payment, and the unpaid balance of the first [*]
Annual License Renewal Fees; (ii) the license from CK to AZ for Collaboration
Technology under Section 5.5.1 survives; (iii) the licenses from AZ to CK for AZ
Background Technology (Section 5.2) and AZ Compounds and AZ Compound Data
(Section 5.3) survive, and CK may retain the physical AZ Compounds and AZ
Compound Data in its possession; (iv) AZ's obligation to provide AZ Compounds
under Section 3.2.6 continues and Section 3.2.7 survives; (iv) the
Cytometrix(TM) Hepatotoxicity Module (including backups thereof) shall be
removed from any AZ Facilities in which it has been installed, and all licenses
granted to AZ thereunder shall terminate; and (v) each Party shall retain
identical copies of the images and derived data generated during the Research
Term.

                           (h) In the event of termination by either Party under
Section 8.2.6 (Insolvency): (i) licenses already granted (to and from the
insolvent Party) continue in accordance with their terms and subject to payment
of related fees; (ii) each Party shall pay for services already provided; and
(iii) each Party shall retain identical copies of the images and derived data
generated during the Research Term.

         8.4 ACCRUED LIABILITY. Termination or expiration of this Agreement for
any reason shall not release either Party hereto from any liability that at the
time of such termination or expiration has already accrued to the other Party
prior to such time including any and all damages arising from any breach
hereunder. Such termination or expiration will not relieve a Party from accrued
payment obligations or from obligations that are expressly indicated in this
Agreement to survive termination or expiration of this Agreement.

         8.5 TERMINATION NOT SOLE REMEDY. Termination is not the sole remedy
under this Agreement and, whether or not termination is effected, all other
remedies will remain available except as agreed to otherwise herein.

                    ARTICLE IX - WARRANTY AND INDEMNIFICATION

         9.1 REPRESENTATIONS AND WARRANTIES. Each Party hereby represents and
warrants and covenants as follows:

                           (a) it is duly organized and validly existing under
the laws of the jurisdiction of its incorporation and has full corporate power
and authority to enter into this Agreement and is in good standing with all
relevant governmental authorities;

                           (b) this Agreement is a legal and valid obligation
binding upon such Party and enforceable in accordance with its terms; and
accordingly, it has taken all corporate actions necessary to authorize the
execution and delivery of this Agreement and the performance of its obligations
under this Agreement;

* Certain information on this page has been omitted and filed separately with
  the Commission. Confidential treatment has been requested with respect to the
  omitted portions.

                                      -31-

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AZ AND CK CONFIDENTIAL

                           (c) the execution, delivery and performance of the
Agreement by such Party does not conflict with any agreement, instrument or
understanding, oral or written, to which it is a party or by which it is bound,
nor violate any law or regulation of any court, governmental body or
administrative or other agency having jurisdiction over it;

                           (d) it has not, and during the term of the Agreement
will not, grant any right to any Third Party relating to its respective
Technology in the Field which would conflict with the rights granted to the
other Party hereunder;

                           (e) it has the requisite rights to grants the
licenses set forth under this Agreement; and further, to the best of its
knowledge, as of the Effective Date there is no pending litigation or claim, and
no basis for such claim, challenging its right to grant the rights herein; and

                           (f) the execution, delivery and performance of this
Agreement will not result in a violation of, or be in material conflict with, or
constitute a material default, under any agreement in existence as of the
Effective Date between CK and Third Parties and that CK is not party to any
agreements that limit or in any other way affect or impair AZ's rights or
obligations under this Agreement, including but not limited to CK's rights and
obligations under that certain agreement between CK and GlaxoSmithKline dated
June 20, 2001.

         9.2 WARRANTY DISCLAIMER. EXCEPT FOR ANY EXPRESS WARRANTY SET FORTH
WITHIN THIS AGREEMENT, ALL COMPOUNDS, THE CM SYSTEM, THE CYTOMETRIX
HEPATOTOXICITY MODULE, TECHNOLOGY AND OTHER MATERIALS PROVIDED BY THE PARTIES
HEREUNDER ARE PROVIDED "AS IS" AND TO THE MAXIMUM EXTENT PERMITTED BY APPLICABLE
LAW THE PARTIES HEREBY DISCLAIM AND EXCLUDE ANY AND ALL REPRESENTATIONS,
WARRANTIES, CONDITIONS OR OTHER TERMS, WHETHER WRITTEN OR ORAL, EXPRESSED OR
IMPLIED, INCLUDING ANY REPRESENTATION OR WARRANTY OF QUALITY, PERFORMANCE,
MERCHANTABILITY OR FITNESS FOR A PARTICULAR USE OR PURPOSE.

         9.3 NO LIABILITY WITH RESPECT TO COMPOUNDS AND COMPOUND DATA. TO THE
FULLEST EXTENT PERMITTED BY APPLICABLE LAW, NEITHER PARTY SHALL BE LIABLE TO THE
OTHER PARTY, OR ANY OF ITS EMPLOYEES OR AGENTS, WHETHER FOR BREACH OF CONTRACT,
NEGLIGENCE OR OTHERWISE, WITH REGARD TO THE PROVISION OF COMPOUNDS OR COMPOUND
DATA, EXCEPT FOR A BREACH OF ITS OBLIGATIONS TO DELIVER AND LICENSE SUCH
COMPOUNDS OR COMPOUND DATA UNDER THIS AGREEMENT IN ACCORDANCE WITH THE TERMS
HEREOF.

         9.4 INDEMNITY.

                  9.4.1    INDEMNIFICATION BY CK. In addition to any other
remedy available to AZ, CK shall indemnify, defend and hold harmless AZ, its
Affiliates and its and their respective agents, employees, officers and
directors (the "AZ INDEMNITEES") from and against any and all

                                      -32-

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AZ AND CK CONFIDENTIAL

liability, claims, demands, causes of action, damage, loss, cost or expense
(including reasonable attorneys' fees) arising out of Third Party claims or
suits to the extent resulting from: (i) CK's performance of, or failure to
perform, its obligations under this Agreement; or (ii) breach by CK of any of
its representations and warranties under Section 9.1 above, provided, however,
that CK's obligations pursuant to this Section 9.4 shall not apply to the extent
such claims or suits result from the negligence or willful misconduct of any of
the AZ Indemnitees.

                  9.4.2    INDEMNIFICATION BY AZ. In addition to any other
remedy available to CK, AZ shall indemnify, defend and hold harmless CK, its
Affiliates and its and their respective agents, employees, officers and
directors (the "CK INDEMNITEES") from and against any and all liability, claims,
demands, causes of action, damage, loss, cost or expense (including reasonable
attorneys' fees) arising out of Third Party claims or suits to the extent
resulting from: (i) AZ's performance of, or failure to perform, its obligations
under this Agreement; or (ii) breach by AZ of any of its representations and
warranties under Section 9.1 above; provided, however, that AZ's obligations
pursuant to this Section 9.4 shall not apply to the extent such claims or suits
result from the negligence or willful misconduct of any of the CK Indemnitees.

                  9.4.3    NOTIFICATION OF CLAIM; CONDITIONS TO INDEMNIFICATION
OBLIGATIONS.

                           (a) As a condition to a Party's right to receive
indemnification under this Section 9.4, it shall: (i) promptly notify ("CLAIM
NOTICE") the other Party as soon as it becomes aware of a claim or suit for
which indemnification may be sought pursuant hereto (provided that the failure
to give a Claim Notice promptly shall not prejudice the rights of an indemnified
Party except to the extent that the failure to give such prompt notice
materially prejudices the indemnifying Party; however, in no event shall the
indemnifying Party be liable for any loss that results from any delay in
providing the Claim Notice); (ii) cooperate with the indemnifying Party in the
defense of such claim or suit, at the expense of the indemnifying Party,
including providing reasonable information, including, but not limited to,
copies of all papers and official documents received in respect of any such
loss; and (iii) if the indemnifying Party confirms in writing to the indemnified
Party its intention to defend such claim or suit within ten (10) days of receipt
of the Claim Notice, permit the indemnifying Party to control the defense of
such claim or suit, including without limitation the right to select defense
counsel; provided that if the indemnifying Party fails to (x) provide such
confirmation in writing within the ten (10) day period or (y) diligently and
reasonably defend such suit or claim at any time, its right to defend the claim
or suit shall terminate immediately in the case of (x) and otherwise upon twenty
(20) days' written notice to the indemnifying Party without cure and the
indemnified Party may assume the defense of such claim or suit at the sole
expense of the indemnifying Party and may settle or compromise such claim or
suit without the consent of the indemnifying Party. In no event, however, may
the indemnifying Party compromise or settle any claim or suit in a manner which
admits fault or negligence on the part of any indemnified Party or that
otherwise materially affects such indemnified Party's rights or requires any
payment by an indemnified Party without the prior written consent of such
indemnified Party. Subject as expressly provided above, the indemnifying Party
will have no liability under this Section 9.4 with respect to claims or suits
settled or compromised (including by admission) without its prior written
consent.

                                      -33-

<PAGE>

AZ AND CK CONFIDENTIAL

                           (b) Each Claim Notice shall contain a description of
the claim and the nature and amount of the loss claimed (to the extent that the
nature and amount of such loss is known at such time).

                            ARTICLE X - MISCELLANEOUS

         10.1     GOVERNING LAW. The interpretation and construction of this
Agreement and any dispute arising from the performance or breach hereof shall be
governed by and construed and enforced in accordance with, the laws of the State
of New York, United States of America, excluding any conflicts or choice of law
rule or principle that might otherwise refer construction or interpretation of
this Agreement to the substantive law of another jurisdiction.

         10.2     DISPUTE RESOLUTION. Prior to initiating any proceeding before
a court or arbitrator, or in another tribunal, all outstanding matters arising
under this Agreement must be submitted to the JSC for good faith negotiation as
described in Section 2.4, and then for resolution pursuant to Section 2.5.
Matters not resolved under Section 2.5 will be referred to the Chief Executive
Officer for CK, and Executive Vice President, Head of Global Discovery Research
for AZ (collectively the "SENIOR MANAGEMENT") for resolution. Any final decision
mutually agreed to by Senior Managements of the Parties shall be in writing and
shall be conclusive and binding on the Parties. If resolution cannot be reached
by the Senior Management within thirty (30) days from the date the matter in
dispute is first brought to the attention of the Senior Management, the dispute
is subject to arbitration under Section 10.3.

         103      ARBITRATION. Except as set forth in Sections 2.4 and 2.5, any
dispute arising out of or relating to the negotiation, interpretation, breach or
performance of this Agreement shall be settled by binding arbitration in
accordance with the rules of arbitration indicated below. The number of
arbitrators shall be three (3), of whom each Party shall appoint one (1). The
two arbitrators so appointed will select the third and final arbitrator. The
place of arbitration shall be San Francisco, California. The language used in
the arbitration proceedings shall be English. The proceedings, including any
outcome, shall be confidential. The arbitration shall be governed by the United
States Arbitration Act 9 U.S.C. Sections 1-16 to the exclusion of any
inconsistent state laws and judgment on the award rendered by the arbitration
may be entered by any court having jurisdiction. Nothing in this Article X will
preclude either Party from seeking interim or provisional relief from a court of
competent jurisdiction, including a temporary restraining order, preliminary
injunction or other interim equitable relief, concerning a dispute either prior
to or during any arbitration if necessary to protect the interests of such Party
or to preserve the status quo pending the arbitration proceeding.

         10.4     ASSIGNMENT. This Agreement shall not be assignable by either
Party to any Third Party hereto without the written consent of the other Party
hereto; except that either Party shall always have the right, without such
consent, (a) to perform any or all of its obligations and exercise any or all of
its rights under this Agreement through any of its Affiliates, and (b) on
written notice to the other Party, assign any or all of its rights and delegate
any or all of its obligations hereunder to any of its Affiliates or to any
successor in interest (whether by merger, acquisition, asset purchase or
otherwise) to all or substantially all of the business to which this

                                      -34-

<PAGE>

AZ AND CK CONFIDENTIAL

Agreement relates. Any permitted successor of a Party or any permitted assignee
of all of a Party's rights under this Agreement that has also assumed all of
such Party's obligations hereunder in writing shall, upon any such succession or
assignment and assumption, be deemed to be a party to this Agreement as though
named herein. All validly assigned rights of a Party shall inure to the benefit
of and be enforceable by, and all validly delegated obligations of such Party
shall be binding on and be enforceable against, the permitted successors and
assigns of such Party, provided that such Party, if it survives, shall remain
jointly and severally liable for the performance of such delegated obligations
under this Agreement. Any attempted assignment or delegation in violation of
this Section 10.4 shall be void.

         10.5     PERFORMANCE WARRANTY. AZ hereby warrants and guarantees the
performance of any and all rights and obligations by its Affiliate(s).

         10.6     DEBARMENT. To the extent required by applicable law, neither
Party shall use, in any capacity, in connection with the performance of its
obligations under this Agreement, any person debarred or subject to debarment or
otherwise disqualified or suspended from performing the Research Program or
otherwise subject to any restrictions or sanctions by any other governmental or
regulatory authority or professional body with respect to the performance of the
Research Program. Accordingly, to the extent applicable, a Party shall
immediately notify the other Party in writing if any person who is performing
under this Agreement is or becomes debarred or if any action, suit, claim,
investigation, or other legal or administrative proceeding is pending or, to the
best of the Party's knowledge, threatened, that would make any person performing
hereunder a person that is debarred or would preclude the Party from performing
its obligations under this Agreement.

         10.7     FORCE MAJEURE. Except with respect to payment of money, no
Party shall be liable to the other for failure or delay in the performance of
any of its obligations under this Agreement for the time and to the extent such
failure or delay is caused by earthquake, riot, civil commotion, war, terrorist
acts, strike, flood, or governmental acts or restriction, or other cause that is
beyond the reasonable control of the respective Party. The Party affected by
such force majeure will provide the other Party with full particulars thereof as
soon as it becomes aware of the same (including its best estimate of the likely
extent and duration of the interference with its activities), and will use
commercially reasonable efforts to overcome the difficulties created thereby and
to resume performance of its obligations as soon as practicable. If the
performance of any such obligation under this Agreement is delayed owing to such
a force majeure for any continuous period of more than one hundred eighty (180)
days, the Parties hereto will consult with respect to an equitable solution,
including the possibility of the mutual termination of this Agreement.

         10.8     NOTICES. All notices, requests and communications hereunder
shall be in writing and shall be personally delivered or sent by facsimile or
e-mail transmission (receipt confirmed), mailed by registered or certified mail
(return receipt requested), postage prepaid, or sent by international express
courier service, and shall be deemed to have been properly served to the
addressee upon receipt of such written communication, to following addresses of
the Parties, or such other address as may be specified in writing to the other
Party hereto:

                                      -35-

<PAGE>

AZ AND CK CONFIDENTIAL

   IF TO CK,

        ADDRESSED TO:     CYTOKINETICS, INC.
                          280 East Grand Avenue
                          South San Francisco, CA 94080-4808
                          Attention: Robert Blum, Senior Vice President, Finance
                          and Corporate Development, and Chief Financial Officer
                          Telephone: (650) 624-3000
                          Telecopy: (650) 624-3010
                          E-mail: rblum@cytokinetics.com

        WITH A COPY TO:   WILSON SONSINI GOODRICH & ROSATI, PC
                          650 Page Mill Road
                          Palo Alto, CA 94304-1050
                          Attention: Kenneth A. Clark, Esq.
                          Telephone: 415-493-9300
                          Telecopy: 415-493-6811
                          E-mail: kclark@wsgr.com

   IF TO AZ,

        ADDRESSED TO:     ASTRAZENECA AB
                          R&D Headquarters
                          S-151 85 Sodertalje, Sweden
                          Attention: Jan Lundberg
                          Executive Vice President, Discovery Research
                          Telephone: [*]
                          E-mail: [*]

        WITH A COPY TO:   ASTRAZENECA AB
                          LEGAL DEPARTMENT
                          S-151 85 Sodertalje, Sweden
                          Attention: Johannes Linde
                          Associate General Counsel
                          Telephone: [*]
                          Telecopy: [*]

         10.9     WAIVER. Neither Party may waive or release any of its rights
or interests in this Agreement except in writing. The failure or either Party to
assert a right hereunder or to insist upon compliance with any term or condition
of this Agreement shall not constitute a waiver of that right or excuse a
similar subsequent failure to perform any such term or condition. No waiver by
either Party of any condition or term in any one or more instances shall be
construed as a continuing waiver of such condition or term or of another
condition or term.

         10.10    SEVERABILITY. If any provision hereof should be held invalid,
illegal or unenforceable in any jurisdiction, the Parties shall negotiate in
good faith a valid, legal and

* Certain information on this page has been omitted and filed separately with
the Commission. Confidential treatment has been requested with respect to the
omitted portions.

                                      -36-

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AZ AND CK CONFIDENTIAL

enforceable substitute provision that most nearly reflects the original intent
of the Parties and all other provisions hereof shall remain in full force and
effect in such jurisdiction and shall be liberally construed in order to carry
out the intentions of the Parties hereto as nearly as may be possible. Such
invalidity, illegality or unenforceability shall not affect the validity,
legality or enforceability of such provision in any other jurisdiction. In the
event a Party seeks to avoid a provision of this Agreement by asserting that
such provision is invalid, illegal or otherwise unenforceable, the other Party
shall have the right to terminate this Agreement upon thirty (30) days' prior
written notice to the asserting Party, unless such assertion is eliminated and
the effect of such assertion cured within such thirty (30)-day period. Any
termination in accordance with the foregoing sentence shall be deemed a
termination pursuant to Section 8.2 and the Party who made such assertion shall
be deemed the breaching Party.

         10.11    DAMAGES EXCLUSION AND LIMITATION. EXCEPT WITH RESPECT TO
DAMAGES OR OBLIGATIONS ARISING OUT OF UNAUTHORIZED EXPLOITATION OF THE OTHER
PARTY'S INTELLECTUAL PROPERTY RIGHTS OR BREACH OF ARTICLE VII, IN NO EVENT WILL
EITHER PARTY OR ANY OF ITS RESPECTIVE AFFILIATES BE LIABLE TO THE OTHER PARTY OR
ANY OF ITS AFFILIATES FOR SPECIAL, INDIRECT, CONSEQUENTIAL, INCIDENTAL,
EXEMPLARY, OR PUNITIVE DAMAGES, WHETHER IN CONTRACT, WARRANTY, TORT, NEGLIGENCE,
STRICT LIABILITY OR OTHERWISE, INCLUDING BUT NOT LIMITED TO, LOSS OF PROFITS OR
REVENUE OR CLAIMS OF CUSTOMERS OF ANY OF THEM OR OTHER THIRD PARTIES FOR SUCH
DAMAGES. The forgoing applies to obligations and damages under Article IX.

         10.12    ENTIRE AGREEMENT. This Agreement sets forth all the covenants,
promises, agreements, warranties, representations, conditions and understandings
between the Parties hereto and supersedes and terminates all prior agreements
and understanding between the Parties with respect to the subject matter hereof,
including that certain Mutual Non-Disclosure Agreement between the Parties dated
January 29, 2003 (the "NDA"), as amended on July 9, 2003, and on August 11,
2003. Notwithstanding the foregoing, all information exchanged between the
Parties pursuant to the NDA shall be deemed Confidential Information of the
Party that disclosed it thereunder and shall be subject to the terms of this
Article VII. There are no covenants, promises, agreements, warranties,
representations conditions or understandings, either oral or written, between
the Parties with respect to the subject matter hereof other than as set forth
herein. No subsequent alteration, amendment, change or addition to this
Agreement shall be binding upon the Parties hereto unless reduced to writing and
signed by the respective authorized officers of the Parties.

         10.13    INDEPENDENT CONTRACTORS. Nothing herein shall be construed to
create any relationship of employer and employee, agent and principal,
partnership or joint venture between the Parties. Each Party is an independent
contractor. Neither Party shall assume, either directly or indirectly, any
liability of or for the other Party. Neither Party shall have the authority to
bind or obligate the other Party and neither Party shall represent that it has
such authority.

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         10.14    HEADINGS. Headings used herein are for convenience only and
shall not in any way affect the construction of or be taken into consideration
in interpreting this Agreement.

         10.15    COUNTERPARTS AND FACSIMILE SIGNATURES. This Agreement may be
executed in two counterparts, each of which shall be deemed an original, and all
of which together, shall constitute one and the same instrument. This Agreement
may be executed as counterparts and the signature page delivered by facsimile.
The Parties agree that such execution and facsimile delivery shall have the same
force and effect as delivery of an original document with original signatures,
and that each Party may use such facsimile signatures as evidence of the
execution and delivery of this Agreement by both Parties.

              [The remainder of this page left intentionally blank]

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AZ AND CK CONFIDENTIAL

         IN WITNESS WHEREOF, this Agreement is executed by the authorized
representatives of the Parties as of the Effective Date.

ASTRAZENECA AB                         CYTOKINETICS, INC.

By: /s/ Per From                       By: /s/ James Sabry
   ---------------------------            ---------------------------
Name: Per From                         Name: James Sabry

Title: President & CEO                 Title: President and CEO

                                      -39-




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AZ AND CK CONFIDENTIAL

                                  EXHIBIT 1.3

                            AZ BACKGROUND TECHNOLOGY

                                      [*]


*  Certain information on this page has been omitted and filed separately with
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AZ AND CK CONFIDENTIAL

                            EXHIBIT 1.4: AZ COMPOUNDS

         The heading in each column indicates whether the information in that
column should be provided for Public Compounds, Proprietary Compounds, or both.
Information identified with *** is to be provided as of the Effective Date.

<TABLE>
<CAPTION>



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(1) Such an identifier must be unique, but need not be the identifier used
    internally at the providing Party.

(2) If Compound is Proprietary, then in addition to the target class, identify
    whether the molecular target is the same.

(3) Reported as an EC50.

(4) Reported as a curve, not as an EC50.



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<PAGE>

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                                      -2-

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<TABLE>
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</TABLE>
                                     -3-
<PAGE>

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<TABLE>
<CAPTION>



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<TABLE>
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                                      -5-
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<TABLE>
<CAPTION>




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<TABLE>
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*  Certain information on this page has been omitted and filed separately with
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omitted portions.

                                      -7-
<PAGE>

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<TABLE>
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*    Certain information on this page has been omitted and filed separately with
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                                      -8-
<PAGE>

AZ AND CK CONFIDENTIAL

                                  EXHIBIT 1.10

                            CK BACKGROUND TECHNOLOGY

         CK Background Technology comprises the Technology disclosed in the
following patents and patent applications.

<TABLE>
<CAPTION>
            APPLN. NO. /    FILING
CASE NO.     (PUB. NO.)      DATE                TITLE / SUBJECT MATTER                STATUS / NOTES
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<S>         <C>            <C>        <C>                                             <C>
1008        [*]            [*]        [*]                                             Pending

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</TABLE>

* Certain information on this page has been omitted and filed separately with
  the Commission. Confidential treatment has been requested with respect to the
  omitted portions.
<PAGE>

AZ AND CK CONFIDENTIAL

<TABLE>
<CAPTION>
            APPLN. NO. /    FILING
CASE NO.     (PUB. NO.)      DATE                 TITLE / SUBJECT MATTER                 STATUS / NOTES
---------------------------------------------------------------------------------------------------------
<S>         <C>            <C>        <C>                                               <C>
1011.1EP       [*]            [*]        [*]                                            Pending

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</TABLE>

* Certain information on this page has been omitted and filed separately with
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                                      -2-

<PAGE>

AZ AND CK CONFIDENTIAL

<TABLE>
<CAPTION>
            APPLN. NO. /     FILING
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</TABLE>


* Certain information on this page has been omitted and filed separately with
  the Commission. Confidential treatment has been requested with respect to the
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                                      -3-

<PAGE>

AZ AND CK CONFIDENTIAL

                                  EXHIBIT 1.11

                                  CK COMPOUNDS

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-------------------------

(1) Such an identifier must be unique, but need not be the identifier used
    internally at the providing Party.

(2) If Compound is Proprietary, then in addition to the target class, identify
    whether the molecular target is the same.

(3) Reported as an EC50.

(4) Reported as a curve, not as an EC50.

* Certain information on this page has been omitted and filed separately with
  the Commission. Confidential treatment has been requested with respect to the
  omitted portions.
<PAGE>

AZ AND CK CONFIDENTIAL

<TABLE>
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* Certain information on this page has been omitted and filed separately with
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                                      -2-
<PAGE>

AZ AND CK CONFIDENTIAL

                                  EXHIBIT 1.15

                                    CM SYSTEM

The CM System is an automated cell biology platform designed to quantify
cellular phenotypes. Cytokinetics has developed the CM System for use across the
drug discovery process, including target identification and validation, primary
and secondary compound screening, mechanism-of-action studies and compound
attrition management.

The components of the current CM System can be broken down as follows:

         -        Culture and plating of cells

         -        Automated addition of treatments and stains

         -        Variable exposure of cells to treatment

         -        Automated image acquisition

         -        Cell-by-cell image analysis

         -        Quantitative cell-by-cell biological analysis

         -        Statistical analysis to generate compound "fingerprints" and
                  compound classifications

All the experimental data, including images, compound fingerprints and
classifications are available for interpretation and decision support.

                            [CM SYSTEM FLOW DIAGRAM]

CELL CULTURE

A variety of cell lines and primary cell types are used in the CM System. The
phenotype of interest is generally dependent on the cell type. By quantitatively
comparing the response to a treatment across a variety of cell types, a fuller
understanding of the effect of the treatment can be obtained. The cell types
employed in the CM System have been selected for relevance to particular
therapeutic problems, for biological diversity, for responsiveness in CM
profiling experiments, and for reproducibility.

TREATMENT

The CM System can be used to quantify the effects of chemical compounds, or a
variety other treatments, such as antibodies, toxins and transfected siRNAs, on
the chosen cell types. The process of defining the CM experiment and the
resulting required treatment plate format is handled in the in the CM System
LIMS.

<PAGE>

AZ AND CK CONFIDENTIAL

AUTOMATED PLATE PREPARATION

The CM System automation includes the plating of cells, incubation with
treatment and staining of the cells. Quantitative reproducibility of assay
results requires consistent fluidics. The CM System LIMS include data system
interfaces for all fluidics operations.

IMAGING

High-quality imaging provides the primary data for the CM System. Imaging data
are automatically stored to computer disk for analysis.

IMAGE ANALYSIS

Proprietary image analysis algorithms are used to segment images into individual
cells and organelles. A large number of morphological and intensity-related
features are extracted from each image. The CM System uses a scalable
distributed computing architecture designed to take advantage of additional
networked computers as computation demands increase. All results are stored in
the CM System experiment database.

DATA ANALYSIS

CM System data analysis quantifies compound "fingerprints" in three phases:

         -        sub-cellular measurements

         -        biological features

         -        compound fingerprints

The process of generating compound fingerprints uses the image features, such as
object area, intensity, shape, texture, etc., and experimental process
parameters, e.g. drug, concentration, cell line, time point, etc., to generate
so-called biological features. Examples of biological features from
Cytokinetics' cell-cycle work include Mitotic Index, G1 phase, S phase, and
Golgi apparatus classification. Treatment fingerprints are the CM System
representation of the cellular phenotype and are generated from multidimensional
analysis of the biological features. Compound groups are assembled when a group
of compound phenotypes is compared and compounds with similar fingerprints are
assembled.

VISUALIZATION

CM System data can be reviewed at many levels, including visualizing compound
fingerprints, reviewing biological analysis and viewing the original
experimental images. Various biological reports and analyses are generated
allowing access to information and analyses at any of the three levels:

         -        Compound Fingerprint Analyses

                                      -2-
<PAGE>

AZ AND CK CONFIDENTIAL

         -        Standardized and Ad Hoc Biological Reports

         -        Biological Experimental Data

The highest level is the compound fingerprint analyses, examples of which are
Principal Component Analysis (PCA) Plots and Trellis Plots. The former are
three-dimensional representations of the higher-dimensional dose-response data,
the latter are representations of the fingerprint data at a given dose.
Standardized and ad hoc biological reports, include cell-cycle analysis and
dose- and time-response curves. Biological experimental data constitute the
primary level and include all the data collected during the CM System
experiment, such as the treatment name and concentration, cell type, marker,
imaging parameters, extracted features, and exposure time.

An exemplary use of the CM System in compound profiling has the following
hierarchy of data:

                   [TYPES OF DATA GENERATED BY THE CM SYSTEM]

              FIGURE 1: Types of data generated by the CM System.

                                      -3-
<PAGE>

AZ AND CK CONFIDENTIAL

                                  EXHIBIT 1.23

                                  DELIVERABLES

This Exhibit 1.23 defines the Deliverables for the Research Program.

CELL CULTURE

The [*] for preparing and handling the [*] used in the CHM will be [*]. Initial
implementation will be at [*] on [*]. In accordance with the Research Plan, the
[*] will be subsequently [*] at [*] using [*]. The [*] will be [*].

TREATMENT PREPARATION

The CHM [*] and the associated [*] will be [*] for initial implementation at [*]
within [*]. Acknowledging that [*] has its own [*] and [*], [*] will provide to
[*] of the [*], including the definition of the [*] and the [*] enabling [*] to
[*] for use on [*].

AUTOMATED PLATE PREPARATION

The [*] will include [*], [*], and [*]. The [*] for [*] will be [*] and [*]. The
[*] will include both [*] and [*] for all necessary [*]. Again, acknowledging
that [*] has its own [*] and [*], [*] will provide to [*] on the [*], enabling
[*] to [*] for use on [*].

IMAGING

The [*] will be generated at [*] using an [*] or comparable [*] and [*]. The
data will be [*] for subsequent [*] and [*]. The [*], [*] and [*] for [*] and
[*] to specific locations to support the [*] will be [*], documented [*] for
usage on [*] and [*].

* Certain information on this page has been omitted and filed separately with
  the Commission. Confidential treatment has been requested with respect to the
  omitted portions.

<PAGE>

AZ AND CK CONFIDENTIAL

IMAGE ANALYSIS

The parties will develop CHM [*] characterizing [*], [*], [*]. Those [*] will be
[*], [*] and [*] at [*] during the [*]. [*] and [*] will be stored in the [*].
[*] will [*] the [*] and [*] and [*] of the [*] as part of the CHM.

DATA ANALYSIS

The parties will [*], [*] and [*] CHM [*] analogous to
[*], as appropriate to [*]. [*] will document and provide to [*] for
[*] for use at [*]
as part of the CHM. [*] will [*] of this [*] on [*] and [*] at [*] on the [*].

VISUALIZATION

The parties will [*] via [*], [*], [*] and [*]. The [*] CHM [*] and [*] will be
[*] and [*] to [*] for usage at [*] as part of the CHM. [*] will [*] the [*] of
this [*] on [*] and [*] at [*] on [*] as part of the CHM.

OVERALL CHM PROCESS - [*]

In addition, an [*] which [*] the [*], [*] and [*] for [*] and [*] the [*] and
to [*] of the [*]) will be [*] and [*] to [*] so that [*] can implement
necessary [*] within [*] on [*] a part of the CHM.

INFORMATION EXCHANGE DURING THE RESEARCH TERM

In the course of the [*], a [*] of [*] will need to be [*]. The [*] of the [*],
[*], the [*] and of the [*], the [*] and the [*], will be [*] at [*]. [*] will
require [*] to the [*].

[*] will be [*] as [*], [*] and [*] for [*] in [*]. The [*] will be

* Certain information on this page has been omitted and filed separately with
  the Commission. Confidential treatment has been requested with respect to the
  omitted portions.

                                      -2-


<PAGE>

AZ AND CK CONFIDENTIAL

provided for use with [*]. [*] is responsible for acquiring its own [*].

[*]

[*]

ACCESS TO [*] EMPLOYED DURING THE RESEARCH TERM OF THE COLLABORATION

[*]

[*]

THE CYTOMETRIX(TM) HEPATOTOXICITY MODULE: [*] DELIVERED TO AZ FOR IDENTIFICATION
OF HEPATOTOXICITY IN [*] DURING THE [*]

[*] of the [*], [*], [*], [*] and [*] for the overall [*] and the [*] will be
delivered to [*] during the [*]. [*] will be [*] on the [*] and [*] of the CHM
per the [*].

[*] and [*] with [*] for [*], [*] and [*] will be delivered. The [*] will
constitute the [*] of the Cytometrix(TM) Hepatotoxicity Module, from [*] to [*]
of a [*]. [*] on the [*] and [*] will be provided.

[*]

[*]

[*]

[*]

[*]

* Certain information on this page has been omitted and filed separately with
  the Commission. Confidential treatment has been requested with respect to the
  omitted portions.

                                      -3-
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AZ AND CK CONFIDENTIAL

[*]

THIRD PARTY PRODUCTS INCLUDED IN THE DELIVERABLES

[*]

INFORMATION EXCHANGE

[*]
[*]
[*]
[*]

ALGORITHMS USED AS PART OF THE RESEARCH PLAN

[*]
[*]

[*]

[*]

CYTOMETRIX(TM) HEPATOTOXICITY MODULE

Hardware systems:

All computers are to be Intel(R) Pentium(R) series, operating systems are to be
Microsoft(R) Windows(R) 2000 or above.
(Memory, processor requirements TBD)

Applications Software:

[*]

[*]

[*]

[*]

[*]

* Certain information on this page has been omitted and filed separately with
  the Commission. Confidential treatment has been requested with respect to the
  omitted portions.

                                       -4-
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AZ AND CK CONFIDENTIAL

[*]

[*]

[*]

[*]


*    Certain information on this page has been omitted and filed separately with
     the Commission. Confidential treatment has been requested with respect to
     the omitted portions.

                                      -5-
<PAGE>

AZ AND CK CONFIDENTIAL

                                  EXHIBIT 1.25

                                EXEMPT ACTIVITIES

AZ: With respect to AZ, Exempt Activities means the:

[*]

[*]

CK: With respect to CK, Exempt Activities means the:

[*]

[*]

* Certain information on this page has been omitted and filed separately with
  the Commission. Confidential treatment has been requested with respect to the
  omitted portions.

<PAGE>
AZ AND CK CONFIDENTIAL

                                  EXHIBIT 1.36

                              PERFORMANCE CRITERIA

[*]

[*]

[*]

[*]

[*]


*Certain information on this page has been omitted and filed separately with the
 Commission. Confidential treatment has been requested with respect to the
 omitted portions.

<PAGE>

AZ AND CK CONFIDENTIAL

                                  EXHIBIT 1.45

                                  RESEARCH PLAN

                                REVISION HISTORY

<TABLE>
<S>                  <C>           <C>                <C>
[*]                  [*]           First Draft        2 pages
Cytokinetics

[*]                  [*]           Version 1.0
AstraZeneca

[*]                  [*]           Version 1.7
AstraZeneca

[*]                  [*]           Version 1.8
Cytokinetics

[*]                  [*]           Version 1.9
Cytokinetics

[*]                  [*]           Version 2.0
Cytokinetics

WSGSR                [*]           Version 2.1        Editing and consistency
                                                      with main body of
                                                      Agreement
</TABLE>

*Certain information on this page has been omitted and filed separately with the
 Commission. Confidential treatment has been requested with respect to the
 omitted portions.

<PAGE>

AZ AND CK CONFIDENTIAL

                                TABLE OF CONTENTS

<TABLE>
<S>                                                      <C>
1.       Introduction                                    1

         1.1    Discovery Problems                       1

         1.2    Approach                                 1

         1.3    Project Aims                             2

2        Project Organisation                            2

         2.1    Roles and Responsibilities               2

         2.2    Meetings Plan                            2

         2.3    Communication Formats                    2

3.       Respective Contributions                        3

4.       Project Plan                                    7

         4.1    Project Phases                           7

         4.2    Collaboration Deliverables               9
</TABLE>

                                      -i-

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AZ AND CK CONFIDENTIAL

ARTICLE I         INTRODUCTION

1.1      DISCOVERY PROBLEMS

Section 1.01 Candidate Drugs (CDs) that fail to make it to market are both
common and expensive. It has been estimated that that less than 10% of CDs
result in a marketable product with each late stage failure incurring
significant costs. Approximately 50% of these failures can be attributed to
toxicological problems. There will be a greater need for early stage profiling
in the future as high throughput screening increases the number of active
compounds per target. Clearly, improved early stage toxicity profiling will aid
the selection of CDs less likely to fail in the development phase and allow a
more informed decision about which active compounds should be progressed.

1.2      APPROACH

Section 1.02 [*]


Section 1.03 [*]


Section 1.04 [*]



*Certain information on this page has been omitted and filed separately with the
 Commission. Confidential treatment has been requested with respect to the
 omitted portions.

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AZ AND CK CONFIDENTIAL

1.3      PROJECT AIMS

The project aim is to utilise the expertise and knowledge within both companies
to develop a high content biology platform for hepatotoxicity profiling of
compounds. At the end of the collaboration the platform would be available for
use in both companies in their own R&D programmes.

To share between AZ and CK [*] and AZ proprietary toxicological data.

[*]

ARTICLE II        PROJECT ORGANISATION

2.1      ROLES AND RESPONSIBILITIES - TO BE APPOINTED

2.2      MEETINGS PLAN

         Weekly telephone conference calls/NetMeeting will be held between AZ &
         CK scientists to discuss detailed scientific progress and issues.

         Monthly video conference calls of project management team

         Quarterly visits, alternating between AZ and CK will be held.

         All meetings are to be scheduled at the outset of each project phase,
         agendas to be circulated at least 2 days before weekly meetings, and 1
         week before monthly and quarterly.

2.3      COMMUNICATION FORMATS

         All documents will follow the defined project format (attach templates)
         in MS Word for Windows v2000 or MS PowerPoint for Windows v2000. Up to
         date project plan will be available to all parties in MS Project for
         Windows v2000. MS Project will be used for GANT charts.

* Certain information on this page has been omitted and filed separately with
  the Commission. Confidential treatment has been requested with respect to the
  omitted portions.

                                      -2-

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AZ AND CK CONFIDENTIAL

ARTICLE III       RESPECTIVE CONTRIBUTIONS

         FTE commitments are man-years for the complete lifetime of the project
- nominally [*] months.

<TABLE>
<CAPTION>
                           AZ                                   CK
------------------------------------------------------------------------------------------------
<S>                        <C>                                  <C>
[*]                           [*] FTE                              [*] FTE
----------------------------------------------------------
[*]                           [*]                                  [*]

                              [*]                                  [*]

                              [*]                                  [*]

                              [*]

                              [*]
----------------------------------------------------------
[*]                           [*]                                  [*]

                              [*]                                  [*]
------------------------------------------------------------------------------------------------
[*]                           [*]
------------------------------------------------------------------------------------------------
</TABLE>

* Certain information on this page has been omitted and filed separately with
  the Commission. Confidential treatment has been requested with respect to the
  omitted portions.


                                      -3-

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AZ AND CK CONFIDENTIAL

<TABLE>
<S>                        <C>                                  <C>
[*]                        [*] FTE                              [*] FTE

                           [*]                                  [*]

                           [*]

                               [*]

                               [*]

                               [*]

                               [*]

                               [*]

                               [*]

                               [*]
------------------------------------------------------------------------------------------------
[*]                        [*] FTE

                           [*]

------------------------------------------------------------------------------------------------
[*]                        [*] FTE                              [*] FTE

                           [*]                                  [*]

                                                                [*]
------------------------------------------------------------------------------------------------
</TABLE>

* Certain information on this page has been omitted and filed separately with
  the Commission. Confidential treatment has been requested with respect to the
  omitted portions.

                                    -4-

<PAGE>

AZ AND CK CONFIDENTIAL

<TABLE>
<S>                        <C>                                  <C>
[*]                        [*]FTE                               [*]FTE
                           [*]                                  [*]
                           [*]                                  [*]
                                                                [*]
------------------------------------------------------------------------------------------------
[*]                                                             [*]FTE
                                                                [*]
-----------------------------------------------------------------------------------------------
[*]                        [*]FTE                               [*]FTE
                           [*]                                  [*]
                                                                [*]
------------------------------------------------------------------------------------------------
[*]                        [*]FTE                               [*]FTE
                           [*]                                  [*]
                                                                [*]
                                                                [*]
                                                                [*]
                                                                [*]
------------------------------------------------------------------------------------------------
</TABLE>

* Certain information on this page has been omitted and filed separately with
  the Commission. Confidential treatment has been requested with respect to the
  omitted portions.

                                       -5-

<PAGE>

AZ AND CK CONFIDENTIAL

<TABLE>
<S>                       <C>                                   <C>
     [*]                                                        [*] FTE
                                                                [*]

------------------------------------------------------------------------------------------------
     [*]                  [*] FTE                               [*] FTE
                          [*]                                   [*]
                          [*]                                   [*]
                          [*]


------------------------------------------------------------------------------------------------
     [*]                  [*] FTE                               [*] FTE
                          [*]                                   [*]
                          [*]
                          [*]
                          [*]
                          [*]
                          [*]

------------------------------------------------------------------------------------------------
     [*]                  [*] FTE [*]                            [*] FTE [*]
                          [*]
                          [*]




------------------------------------------------------------------------------------------------
</TABLE>

* Certain information on this page has been omitted and filed separately with
  the Commission. Confidential treatment has been requested with respect to
  the omitted portions.

                                       -6-

<PAGE>

AZ AND CK CONFIDENTIAL

ARTICLE IV        PROJECT PLAN

4.1      PROJECT PHASES
         [*]

         [*]

         [*]

         [*]

         [*]

         [*]

         [*]

         [*]

         [*]

         [*]

         [*]

         [*]

         [*]

         [*]

         [*]

         [*]

         [*]


* Certain information on this page has been omitted and filed separately with
  the Commission. Confidential treatment has been requested with respect to
  the omitted portions.

                                      -7-

<PAGE>

AZ AND CK CONFIDENTIAL

[*]

[*]

[*]

[*]

[*]

[*]

[*]

[*]

[*]

[*]

[*]

[*]

[*]

[*]

[*]

[*]

*    Certain information on this page has been omitted and filed separately with
     the Commission. Confidential treatment has been requested with respect to
     the omitted portions.

                                      -8-

<PAGE>

AZ AND CK CONFIDENTIAL

4.2      DELIVERABLES FOR RESEARCH PROGRAM:

         The Deliverables for the Research Program are defined in Exhibit 1.23
of the Agreement.

                                      -9-

<PAGE>

AZ AND CK CONFIDENTIAL

                                  EXHIBIT 5.6.2

                                     SUPPORT

DURING THE [*] WILL:

-    Perform installation of the [*] at [*]. Given prior preparation, by [*], of
     the required [*] on the [*] at a [*] this effort is estimated to take [*]
     to complete.

-    Supply [*] with a [*] and [*] for its own use in the event of [*] during
     the [*].

-    Train [*] on [*].

-    Supply [*] with [*] for the [*] as defined in Deliverables Exhibit 1.23.

-    Prepare [*] as necessary and [*] to [*] with [*].

IN THE EVENT OF [*], WHETHER DURING THE [*] OR [*], [*] WILL:

-    Expect that [*] will [*] from the [*] and [*] supplied by [*] during the
     [*] at [*].

-    Answer [*] via phone, video conference or email regarding [*] or [*] to [*]
     of the CHM.

-    In the event, that the [*] do not result in a [*] at [*], [*] will on a
     [*], [*] to the [*] and [*] a [*] of the CHM.

* Certain information on this page has been omitted and filed separately with
  the Commission. Confidential treatment has been requested with respect to the
  omitted portions.
<PAGE>

                                   EXHIBIT 7.4

<TABLE>
<S>                                                                                <C>
Contacts:

CYTOKINETICS, INC.                                                                 ASTRAZENECA (MEDIA ENQUIRES)
Robert I. Blum                                                                     Steve Brown, +44 (0) 207 304 5033
SVP, Finance and Corporate Development, and CFO                                    Scott Young, +1.781.839.4589
(650) 624-3000                                                                     Kellie Rivest, +1.781.839.4151

BURNS MCCLELLAN, INC.
E. Blair Clark (investors) or Justin Jackson (media)
(212) 213-0006
</TABLE>

FOR IMMEDIATE RELEASE

                      CYTOKINETICS AND ASTRAZENECA ANNOUNCE
       TECHNOLOGY DEVELOPMENT COLLABORATION FOCUSED ON PREDICTIVE TOXICITY

       ALLIANCE LEVERAGES CYTOMETRIX(TM) CELLULAR PHENOTYPING TECHNOLOGIES

SOUTH SAN FRANCISCO, CA AND LONDON, UK, DEC. 18, 2003 - Cytokinetics, Inc., and
AstraZeneca Pharmaceuticals announced today that the two companies have entered
into an exclusive collaboration to develop automated imaging-based cellular
phenotyping and analysis technologies for the in vitro prediction of
hepatotoxicity. The companies have agreed to commit internal resources and
combine efforts aimed at addressing an important inflection point in the
pharmaceutical discovery and development process. Under the terms of the
agreement, AstraZeneca will fund technology development activities at
Cytokinetics over a two-year research term. The agreement further provides for a
milestone payment and annual licensing fees to be paid to Cytokinetics upon the
Cytometrix(TM) Hepatotoxicity Module successfully achieving certain agreed upon
performance criteria.

"Under this collaboration, we have the potential to develop new technologies
that may systematically and reliably predict toxic and non-toxic
pharmacophores," stated Jay Trautman, Ph.D., Cytokinetics' Vice President of
Technology. "AstraZeneca has decades of molecular toxicology and pathology
experience. By combining this expertise with Cytokinetics' validated cellular
phenotyping technologies, we have an opportunity to together bring forward an
application module of the Cytometrix(TM) technologies that may deliver
productivity gains for each of our later stage discovery and pre-clinical
development processes."

AstraZeneca's Vice President and Global Head of Safety Assessment, Peter
Moldeus, Ph.D., stated, "Complications associated with toxicity are a major
challenge for the pharmaceutical industry, as these toxicities often result in a
project's failure after substantial investments have already been made.
Diminishing the risks associated with toxicity by identifying a compound's
off-target liabilities earlier could significantly increase our development
success. We believe that Cytokinetics' Cytometrix(TM) cellular phenotyping
technologies have potential to help AstraZeneca remain at the forefront of
research in this area."

CYTOMETRIX(TM) TECHNOLOGIES

The collaboration will leverage Cytokinetics' proprietary platform,
Cytometrix(TM) cellular phenotyping technologies, which are routinely utilized
in Cytokinetics' screening processes to analyze both on-target and off-target
effects of candidate compounds. Cytometrix(TM) cellular phenotyping technologies
utilize cell-based assays to create digital phenotypic profiles ("fingerprints")
representative of diverse molecular mechanisms of drug action. Cytometrix(TM)
fingerprints detail information on the potency and specificity of a compound or
drug-related toxicities. Cytokinetics presently employs Cytometrix(TM) cellular
phenotyping technologies to eliminate compounds of mixed mechanism, allowing the
company to focus its medicinal chemistry and pharmacology resources more
selectively on higher quality chemical series. This collaboration with
AstraZeneca is designed to develop a new Cytometrix(TM) technologies application
called the Cytometrix(TM) Hepatotoxicity Module for the in vitro prediction of
hepatotoxicities downstream of screening.

                                    - more -

<PAGE>

Cytokinetics and AstraZeneca Collaboration Press Announcement
December 18, 2003
Page 2

ABOUT CYTOKINETICS

Founded in 1998 and privately held, Cytokinetics is dedicated to the discovery,
development and commercialization of a novel class of therapeutics resulting
from its leadership position in the emerging field of cytoskeletal pharmacology.
The cytoskeleton is a complex, dynamic framework that impacts all aspects of
cell function including cell division, cell motility, intracellular transport,
muscle contractility and regulation of cellular organization. Cytokinetics' R&D
efforts aim to address pharmaceutical needs in cancer, cardiovascular and
infectious diseases and feature proprietary Cytometrix(TM) cellular phenotyping
technologies designed to industrialize cell biology for increased speed and
productivity in drug discovery and development. Cytokinetics and GlaxoSmithKline
have entered into a broad strategic collaboration to discover, develop and
commercialize novel small molecule therapeutics targeting mitotic kinesins for
applications in the treatment of cancer and other diseases. Cytokinetics and
GlaxoSmithKline are conducting Phase I studies with the first novel anti-cancer
drug candidate emerging from the collaboration and intend to expand clinical
development upon completion of these studies. Additional information about
Cytokinetics can be obtained at www.cytokinetics.com.

ABOUT ASTRAZENECA

AstraZeneca is a major international healthcare business engaged in the
research, development, manufacture and marketing of prescription pharmaceuticals
and the supply of healthcare services. It is one of the top five pharmaceutical
companies in the world with healthcare sales of over $17.8 billion and leading
positions in sales of gastrointestinal, oncology, cardiovascular, neuroscience
and respiratory products. AstraZeneca is listed in the Dow Jones Sustainability
Index (Global and European) as well as the FTSE4Good Index. Worldwide,
AstraZeneca has six major research and development sites and four discovery
sites employing more then 11,000 people in six countries including Canada,
France, India, Sweden, United Kingdom and the United States. For more
information, please visit www.astrazeneca.com/research.

                                      # # #