WARNING: THE EDGAR SYSTEM ENCOUNTERED ERROR(S) WHILE PROCESSING THIS SCHEDULE.

<TABLE> <S> <C>

<ARTICLE> 6
<CIK> 0000862502
<NAME> Salomon Brothers Large Cap Growth Fund
<SERIES>
   <NUMBER>012
   <NAME>Salomon Brothers Investment Series Funds Inc.

<S>                             <C>
<PERIOD-TYPE>                  6-MOS
<FISCAL-YEAR-END>                               Dec-31-2000
<PERIOD-END>                                    Jun-30-2000
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<INVESTMENTS-AT-VALUE>                           13,643,175
<RECEIVABLES>                                       200,501
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<OTHER-ITEMS-ASSETS>                                      0
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<PAYABLE-FOR-SECURITIES>                                  0
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<SHARES-COMMON-STOCK>                               238,340
<SHARES-COMMON-PRIOR>                               110,603
<ACCUMULATED-NII-CURRENT>                           (67,025)
<OVERDISTRIBUTION-NII>                                    0
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<OTHER-INCOME>                                            0
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<NET-INVESTMENT-INCOME>                             (67,025)
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<NET-CHANGE-FROM-OPS>                              (451,843)
<EQUALIZATION>                                            0
<DISTRIBUTIONS-OF-INCOME>                                 0
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<DISTRIBUTIONS-OTHER>                                     0
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<EXPENSE-RATIO>                                        2.20



</TABLE>