EXHIBIT 4.1

                          SECURITIES PURCHASE AGREEMENT

      This Securities Purchase Agreement (this "Agreement") is dated as of
January 8, 2004, among Axonyx, Inc., a Nevada corporation (the "Company"), and
the purchasers identified on the signature pages hereto (each a "Purchaser" and
collectively the "Purchasers"); and

      WHEREAS, subject to the terms and conditions set forth in this Agreement
and pursuant to Section 4(2) of the Securities Act (as defined below), and Rule
506 promulgated thereunder, the Company desires to issue and sell to the
Purchasers, and each Purchaser, severally and not jointly, desires to purchase
from the Company in the aggregate, up to $50,000,000 of the Company's Common
Stock and certain Warrants, as more fully described in this Agreement.

      NOW, THEREFORE, IN CONSIDERATION of the mutual covenants contained in this
Agreement, and for other good and valuable consideration the receipt and
adequacy of which are hereby acknowledged, the Company and each Purchaser agrees
as follows:

                                   ARTICLE I.
                                   DEFINITIONS

      1.1 Definitions. In addition to the terms defined elsewhere in this
Agreement, for all purposes of this Agreement, the following terms have the
meanings indicated in this Section 1.1:

            "Action" shall have the meaning ascribed to such term in Section
      3.1(j).

            "Affiliate" means any Person that, directly or indirectly through
      one or more intermediaries, controls or is controlled by or is under
      common control with a Person as such terms are used in and construed under
      Rule 144. With respect to a Purchaser, any investment fund or managed
      account that is managed on a discretionary basis by the same investment
      manager as such Purchaser will be deemed to be an Affiliate of such
      Purchaser.

            "Business Day" means any day except Saturday, Sunday and any day
      which shall be a federal legal holiday or a day on which banking
      institutions in the State of New York are authorized or required by law or
      other governmental action to close.

            "Closing" means the closing of the purchase and sale of the Common
      Stock and Warrant pursuant to Section 2.1(a).

            "Closing Date" means the date of the Closing.

            "Closing Price" means on any particular date (a) the last reported
      closing bid price per share of Common Stock on such date on the Trading
      Market (as reported by Bloomberg L.P. at 4:15 PM (New York time), or (b)
      if there is no such price on such date, then the closing bid price on the
      Trading Market on the date nearest preceding such date (as reported by
      Bloomberg L.P. at 4:15 PM (New York time) for the closing bid price for
      regular session trading on such day), or (c) if the Common Stock is not
      then listed or quoted on the Trading Market and if prices for the Common
      Stock are then


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      reported in the "pink sheets" published by the National Quotation Bureau
      Incorporated (or a similar organization or agency succeeding to its
      functions of reporting prices), the most recent bid price per share of the
      Common Stock so reported, or (d) if the shares of Common Stock are not
      then publicly traded the fair market value of a share of Common Stock as
      determined by an appraiser selected in good faith by the Purchasers of a
      majority in interest of the Shares then outstanding.

            "Commission" means the Securities and Exchange Commission.

            "Common Stock" means the common stock of the Company, $0.001 par
      value per share, and any securities into which such common stock may
      hereafter be reclassified.

            "Common Stock Equivalents" means any securities of the Company or
      the Subsidiaries which would entitle the holder thereof to acquire at any
      time Common Stock, including without limitation, any debt, preferred
      stock, rights, options, warrants or other instrument that is at any time
      convertible into or exchangeable for, or otherwise entitles the holder
      thereof to receive, Common Stock.

            "Company Counsel" means Ehrenreich Eilenberg & Krause LLP.

            "Disclosure Schedules" means the Disclosure Schedules attached as
      Annex I hereto.

            "Effective Date" means the date that the Registration Statement is
      first declared effective by the Commission.

            "Exchange Act" means the Securities Exchange Act of 1934, as
      amended.

            "Intellectual Property Rights" shall have the meaning ascribed to
      such term in Section 3.1(o).

            "Liens" means a lien, charge, security interest, encumbrance, right
      of first refusal or other restriction.

            "Material Adverse Effect" shall have the meaning ascribed to such
      term in Section 3.1(b).

            "Material Permits" shall have the meaning ascribed to such term in
      Section 3.1(m).

            "Per Share Purchase Price" equals $5.15, subject to adjustment for
      reverse and forward stock splits, stock dividends, stock combinations and
      other similar transactions of the Common Stock that occur after the date
      of this Agreement.

            "Per Warrant Purchase Price" equals $0.125, subject to adjustment
      for reverse and forward stock splits, stock dividends, stock combinations
      and other similar transactions of the Common Stock that occur after the
      date of this Agreement


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            "Person" means an individual or corporation, partnership, trust,
      incorporated or unincorporated association, joint venture, limited
      liability company, joint stock company, government (or an agency or
      subdivision thereof) or other entity of any kind.

            "Registration Statement" means a registration statement meeting the
      requirements set forth in the Registration Rights Agreement and covering
      the resale by the Purchasers of the Shares and the Warrant Shares.

            "Registration Rights Agreement" means the Registration Rights
      Agreement, dated as of the date of this Agreement, among the Company and
      each Purchaser, in the form of Exhibit A hereto.

            "Rule 144," means Rule 144 promulgated by the Commission pursuant to
      the Securities Act, as such Rules may be amended from time to time, or any
      similar rule or regulation hereafter adopted by the Commission having
      substantially the same effect as such Rule.

            "SEC Reports" shall have the meaning ascribed to such term in
      Section 3.1(h).

            "Securities" means the Shares, the Warrants and the Warrant Shares.

            "Securities Act" means the Securities Act of 1933, as amended.

            "Shares" means the shares of Common Stock issued or issuable to each
      Purchaser pursuant to this Agreement.

            "Subscription Amount" means, as to each Purchaser and the Closing,
      the amounts set forth below such Purchaser's signature block on the
      signature page hereto, in United States dollars and in immediately
      available funds.

            "Subsidiary" shall have the meaning ascribed to such term in Section
      3.1(a).

            "Trading Day" means (i) a day on which the Common Stock is traded on
      a Trading Market, or (ii) if the Common Stock is not listed on a Trading
      Market, a day on which the Common Stock is traded on the over-the-counter
      market, as reported by the OTC Bulletin Board, or (iii) if the Common
      Stock is not quoted on the OTC Bulletin Board, a day on which the Common
      Stock is quoted in the over-the-counter market as reported by the National
      Quotation Bureau Incorporated (or any similar organization or agency
      succeeding its functions of reporting prices); provided, that in the event
      that the Common Stock is not listed or quoted as set forth in (i), (ii)
      and (iii) hereof, then Trading Day shall mean a Business Day.

            "Trading Market" means the following markets or exchanges on which
      the Common Stock is listed or quoted for trading on the date in question:
      the American Stock Exchange, the New York Stock Exchange, the Nasdaq
      National Market or the Nasdaq SmallCap Market.


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            "Transaction Documents" means this Agreement, the Registration
      Rights Agreement, the Warrants and any other documents or agreements
      executed in connection with the transactions contemplated hereunder.

            "Warrants" means the Common Stock Purchase Warrants, in the form of
      Exhibit B, issuable to the Purchasers at the Closing, with a term of
      exercise of 5 years and an exercise price equal to $7.25, subject to
      adjustment therein.

            "Warrant Shares" means the shares of Common Stock issuable upon
      exercise of the Warrants.

                                  ARTICLE II.
                                PURCHASE AND SALE

      2.1 Closing. At the Closing, the Purchasers shall purchase, severally and
not jointly, and the Company shall issue and sell, in the aggregate, up to
$50,000,000 of Common Stock, together with the Warrants. Each Purchaser shall
purchase from the Company, and the Company shall issue and sell to each
Purchaser, (a) a number of Shares equal to such Purchaser's Subscription Amount
divided by the Per Share Purchase Price and (b) the Warrants as determined
pursuant to Section 2.2(a)(v) at the Per Warrant Purchase Price. Upon
satisfaction of the conditions set forth in Section 2.2, the Closing shall occur
at the offices of Company Counsel, or such other location as the parties shall
mutually agree.

      2.2 Closing Conditions.

            (a) At the Closing the Company shall deliver or cause to be
      delivered to each Purchaser:

                  (i) this Agreement duly executed by the Company;

                  (ii) a certificate evidencing a number of Shares equal to such
            Purchaser's Subscription Amount divided by the Per Share Purchase
            Price, registered in the name of such Purchaser;

                  (iii) the Registration Rights Agreement duly executed by the
            Company;

                  (iv) a legal opinion of Company Counsel, in the form of
            Exhibit C attached hereto; and

                  (v) a Warrant, registered in the name of such Purchaser,
            pursuant to which such Purchaser shall have the right to acquire up
            to the number of shares of Common Stock equal to 25% of the Shares
            to be issued to such Purchaser at the Closing.

            (b) At the Closing each Purchaser shall deliver or cause to be
      delivered to the Company the following:

                  (i) this Agreement duly executed by such;


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                  (ii) such Purchaser's Subscription Amount and Warrant Purchase
            Price by wire transfer to the account of the Company; and

                  (iii) the Registration Rights Agreement duly executed by such
            Purchaser.

            (c) All representations and warranties of the other party contained
      herein shall remain true and correct as of the Closing Date.

            (d) As of the Closing Date, there shall have been no Material
      Adverse Effect with respect to the Company since the date hereof.

            (e) From the date hereof to the Closing Date, trading in the Common
      Stock shall not have been suspended by the Commission (except for any
      suspension of trading of limited duration agreed to by the Company, which
      suspension shall be terminated prior to the Closing), and, at any time
      prior to Closing Date, trading in securities generally as reported by
      Bloomberg Financial Markets shall not have been suspended or limited, or
      minimum prices shall not have been established on securities whose trades
      are reported by such service, or on any Trading Market, nor shall a
      banking moratorium have been declared either by the United States or New
      York State authorities, nor shall there have occurred any material
      outbreak or escalation of hostilities or other national or international
      calamity of such magnitude in its effect on, or any material adverse
      change in, any financial market which, in each case, in the reasonable
      judgment of each Purchaser, makes it impracticable or inadvisable to
      purchase the Shares at the Closing.

                                  ARTICLE III.
                         REPRESENTATIONS AND WARRANTIES

      3.1 Representations and Warranties of the Company. Except as set forth in
the SEC Reports or under the corresponding section of the Disclosure Schedules
delivered concurrently herewith, the Company hereby makes the following
representations and warranties as of the date hereof and as of the Closing Date
to each Purchaser:

            (a) Subsidiaries. The Company has no direct or indirect
      subsidiaries. The Company owns, directly or indirectly, all of the capital
      stock of each Subsidiary free and clear of any lien, charge, security
      interest, encumbrance, right of first refusal or other restriction
      (collectively, "Liens"), and all the issued and outstanding shares of
      capital stock of each Subsidiary are validly issued and are fully paid,
      non-assessable and free of preemptive and similar rights. If the Company
      has no subsidiaries, then references in the Transaction Documents to the
      Subsidiaries will be disregarded.

            (b) Organization and Qualification. Each of the Company and the
      Subsidiaries is an entity duly incorporated or otherwise organized,
      validly existing and in good standing under the laws of the jurisdiction
      of its incorporation or organization (as applicable), with the requisite
      power and authority to own and use its properties and assets and to carry
      on its business as currently conducted. Neither the Company nor any
      Subsidiary is in violation of any of the provisions of its respective
      certificate or articles of incorporation, bylaws or other organizational
      or charter documents. Each of the Company and the Subsidiaries is duly
      qualified to conduct business and is in good


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      standing as a foreign corporation or other entity in each jurisdiction in
      which the nature of the business conducted or property owned by it makes
      such qualification necessary, except where the failure to be so qualified
      or in good standing, as the case may be, would not have or reasonably be
      expected to result in (i) a material adverse effect on the legality,
      validity or enforceability of any Transaction Document, (ii) a material
      adverse effect on the results of operations, assets, business or financial
      condition of the Company and the Subsidiaries, taken as a whole, or (iii)
      adversely impair the Company's ability to perform in any material respect
      on a timely basis its obligations under any Transaction Document (any of
      (i), (ii) or (iii), a "Material Adverse Effect").

            (c) Authorization; Enforcement. The Company has the requisite
      corporate power and authority to enter into and to consummate the
      transactions contemplated by each of the Transaction Documents and
      otherwise to carry out its obligations thereunder. The execution and
      delivery of each of the Transaction Documents by the Company and the
      consummation by it of the transactions contemplated thereby have been duly
      authorized by all necessary action on the part of the Company and no
      further action is required by the Company in connection therewith. Each
      Transaction Document has been (or upon delivery will have been) duly
      executed by the Company and, when delivered in accordance with the terms
      hereof, will constitute the valid and binding obligation of the Company
      enforceable against the Company in accordance with its terms except (i) as
      limited by applicable bankruptcy, insolvency, reorganization, moratorium
      and other laws of general application affecting enforcement of creditors'
      rights generally and (ii) as limited by laws relating to the availability
      of specific performance, injunctive relief or other equitable remedies.

            (d) No Conflicts. The execution, delivery and performance of the
      Transaction Documents by the Company and the consummation by the Company
      of the transactions contemplated thereby do not and will not (i) conflict
      with or violate any provision of the Company's or any Subsidiary's
      certificate or articles of incorporation, bylaws or other organizational
      or charter documents, or (ii) conflict with, or constitute a default (or
      an event that with notice or lapse of time or both would become a default)
      under, or give to others any rights of termination, amendment,
      acceleration or cancellation (with or without notice, lapse of time or
      both) of, any agreement, credit facility, debt or other instrument
      (evidencing a Company or Subsidiary debt or otherwise) or other
      understanding to which the Company or any Subsidiary is a party or by
      which any property or asset of the Company or any Subsidiary is bound or
      affected, or (iii) result in a violation of any law, rule, regulation,
      order, judgment, injunction, decree or other restriction of any court or
      governmental authority to which the Company or a Subsidiary is subject
      (including federal and state securities laws and regulations), or by which
      any property or asset of the Company or a Subsidiary is bound or affected;
      except in the case of each of clauses (ii) and (iii), such as would not
      have or reasonably be expected to result in a Material Adverse Effect.

            (e) Filings, Consents and Approvals. The Company is not required to
      obtain any consent, waiver, authorization or order of, give any notice to,
      or make any filing or registration with, any court or other federal,
      state, local or other governmental authority or other Person in connection
      with the execution, delivery and performance by the Company of the
      Transaction Documents, other than (a) the filing with the Commission of


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      the Registration Statement, the application(s) to each Trading Market for
      the listing of the Shares and Warrant Shares for trading thereon in the
      time and manner required thereby, and applicable Blue Sky filings, (b)
      such as have already been obtained or such exemptive filings as are
      required to be made under applicable securities laws, (c) such other
      filings as may be required following the Closing Date under the Securities
      Act, the Exchange Act and corporate law.

            (f) Issuance of the Securities. The Securities are duly authorized
      and, when issued and paid for in accordance with the Transaction
      Documents, will be duly and validly issued, fully paid and nonassessable,
      free and clear of all Liens. The Company has reserved from its duly
      authorized capital stock the maximum number of shares of Common Stock
      issuable pursuant to this Agreement and the Warrants.

            (g) Capitalization. The capitalization of the Company is as
      described in the Company's most recent periodic report filed with the
      Commission. The Company has not issued any capital stock since such filing
      other than pursuant to the exercise of employee stock options under the
      Company's stock option plans, the issuance of shares of Common Stock to
      employees pursuant to the Company's employee stock purchase plan and
      pursuant to the conversion or exercise of outstanding Common Stock
      Equivalents. No Person has any right of first refusal, preemptive right,
      right of participation, or any similar right to participate in the
      transactions contemplated by the Transaction Documents. Except as a result
      of the purchase and sale of the Securities, there are no outstanding
      options, warrants, script rights to subscribe to, calls or commitments of
      any character whatsoever relating to, or securities, rights or obligations
      convertible into or exchangeable for, or giving any Person any right to
      subscribe for or acquire, any shares of Common Stock, or contracts,
      commitments, understandings or arrangements by which the Company or any
      Subsidiary is or may become bound to issue additional shares of Common
      Stock, or securities or rights convertible or exchangeable into shares of
      Common Stock. Except for certain standard and customary "weighted average"
      anti-dilution adjustment provisions in outstanding warrants of the
      Company, the issue and sale of the Securities will not obligate the
      Company to issue shares of Common Stock or other securities to any Person
      (other than the Purchasers) and will not result in a right of any holder
      of Company securities to adjust the exercise, conversion, exchange or
      reset price under such securities.

            (h) SEC Reports; Financial Statements. The Company has filed all
      reports required to be filed by it under the Securities Act and the
      Exchange Act, including pursuant to Section 13(a) or 15(d) thereof, for
      the two years preceding the date hereof (or such shorter period as the
      Company was required by law to file such material) (the foregoing
      materials, including the exhibits thereto, being collectively referred to
      herein as the "SEC Reports" and, together with the Disclosure Schedules to
      this Agreement, the "Disclosure Materials") on a timely basis or has
      received a valid extension of such time of filing and has filed any such
      SEC Reports prior to the expiration of any such extension. As of their
      respective dates, the SEC Reports complied in all material respects with
      the requirements of the Securities Act and the Exchange Act and the rules
      and regulations of the Commission promulgated thereunder, and none of the
      SEC Reports, when filed, contained any untrue statement of a material fact
      or omitted to state a material fact required to be stated therein or
      necessary in order to make the statements therein, in


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      light of the circumstances under which they were made, not misleading. The
      financial statements of the Company included in the SEC Reports comply in
      all material respects with applicable accounting requirements and the
      rules and regulations of the Commission with respect thereto as in effect
      at the time of filing. Such financial statements have been prepared in
      accordance with generally accepted accounting principles applied on a
      consistent basis during the periods involved ("GAAP"), except as may be
      otherwise specified in such financial statements or the notes thereto and
      except that unaudited financial statements may not contain all footnotes
      required by GAAP, and fairly present in all material respects the
      financial position of the Company and its consolidated subsidiaries as of
      and for the dates thereof and the results of operations and cash flows for
      the periods then ended, subject, in the case of unaudited statements, to
      normal, immaterial, year-end audit adjustments.

            (i) Material Changes. Since the date of the latest audited financial
      statements included within the SEC Reports, except as disclosed in the SEC
      Reports, (i) there has been no event, occurrence or development that has
      had or that could reasonably be expected to result in a Material Adverse
      Effect, (ii) the Company has not incurred any liabilities (contingent or
      otherwise) other than (A) trade payables and accrued expenses incurred in
      the ordinary course of business consistent with past practice and (B)
      liabilities not required to be reflected in the Company's financial
      statements pursuant to GAAP or required to be disclosed in filings made
      with the Commission, and (iii) the Company has not altered its method of
      accounting, (iv) the Company has not declared or made any dividend or
      distribution of cash or other property to its stockholders or purchased,
      redeemed or made any agreements to purchase or redeem any shares of its
      capital stock and (v) the Company has not issued any equity securities to
      any officer, director or Affiliate, except pursuant to existing Company
      stock option plans. The Company does not have pending before the
      Commission any request for confidential treatment of information.

            (j) Litigation. Except as disclosed in the SEC Reports, there is no
      action, suit, inquiry, notice of violation, proceeding or investigation
      pending or, to the knowledge of the Company, threatened against or
      affecting the Company, any Subsidiary or any of their respective
      properties before or by any court, arbitrator, governmental or
      administrative agency or regulatory authority (federal, state, county,
      local or foreign) (collectively, an "Action") which (i) adversely affects
      or challenges the legality, validity or enforceability of any of the
      Transaction Documents or the Securities or (ii) could, if there were an
      unfavorable decision, have or reasonably be expected to result in a
      Material Adverse Effect. Neither the Company nor any Subsidiary, nor any
      director or officer thereof, is or has been the subject of any Action
      involving a claim of violation of or liability under federal or state
      securities laws or a claim of breach of fiduciary duty. There has not
      been, and to the knowledge of the Company, there is not pending or
      contemplated, any investigation by the Commission involving the Company or
      any current or former director or officer of the Company. The Commission
      has not issued any stop order or other order suspending the effectiveness
      of any registration statement filed by the Company or any Subsidiary under
      the Exchange Act or the Securities Act.


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            (k) Labor Relations. No material labor dispute exists or, to the
      knowledge of the Company, is imminent with respect to any of the employees
      of the Company which could reasonably be expected to result in a Material
      Adverse Effect.

            (l) Compliance. Except as disclosed in the SEC Reports, neither the
      Company nor any Subsidiary (i) is in default under or in violation of (and
      no event has occurred that has not been waived that, with notice or lapse
      of time or both, would result in a default by the Company or any
      Subsidiary under), nor has the Company or any Subsidiary received notice
      of a claim that it is in default under or that it is in violation of, any
      indenture, loan or credit agreement or any other agreement or instrument
      to which it is a party or by which it or any of its properties is bound
      (whether or not such default or violation has been waived), (ii) is in
      violation of any order of any court, arbitrator or governmental body, or
      (iii) is or has been in violation of any statute, rule or regulation of
      any governmental authority, including without limitation all foreign,
      federal, state and local laws applicable to its business, except in the
      case of clauses (i), (ii) and (iii) as would not have or reasonably be
      expected to result in a Material Adverse Effect.

            (m) Regulatory Permits. The Company and the Subsidiaries possess all
      certificates, authorizations and permits issued by the appropriate
      federal, state, local or foreign regulatory authorities necessary to
      conduct their respective businesses as described in the SEC Reports,
      except where the failure to possess such permits would not have or
      reasonably be expected to result in a Material Adverse Effect ("Material
      Permits"), and neither the Company nor any Subsidiary has received any
      notice of proceedings relating to the revocation or modification of any
      Material Permit.

            (n) Title to Assets. The Company and the Subsidiaries have good and
      marketable title in fee simple to all real property owned by them that is
      material to the business of the Company and the Subsidiaries and good and
      marketable title in all personal property owned by them that is material
      to the business of the Company and the Subsidiaries, in each case free and
      clear of all Liens, except for Liens as do not materially affect the value
      of such property and do not materially interfere with the use made and
      proposed to be made of such property by the Company and the Subsidiaries
      and Liens for the payment of federal, state or other taxes, the payment of
      which is neither delinquent nor subject to penalties. Any real property
      and facilities held under lease by the Company and the Subsidiaries are
      held by them under valid, subsisting and enforceable leases of which the
      Company and the Subsidiaries are in compliance.

            (o) Patents and Trademarks. To the knowledge of the Company and each
      Subsidiary, the Company and the Subsidiaries have, or have rights to use,
      all patents, patent applications, trademarks, trademark applications,
      service marks, trade names, copyrights, licenses and other similar rights
      that are necessary or material for use in connection with their respective
      businesses as described in the SEC Reports and which the failure to so
      have could have or reasonably be expected to result in a Material Adverse
      Effect (collectively, the "Intellectual Property Rights"). Neither the
      Company nor any Subsidiary has received a written notice that the
      Intellectual Property Rights used by the Company or any Subsidiary
      violates or infringes upon the rights of any Person. To the knowledge of
      the Company, all such Intellectual Property Rights are enforceable.


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            (p) Insurance. The Company and the Subsidiaries are insured by
      insurers of recognized financial responsibility against such losses and
      risks and in such amounts as are prudent and customary in the businesses
      in which the Company and the Subsidiaries are engaged. Neither the Company
      nor any Subsidiary has any reason to believe that it will not be able to
      renew its existing insurance coverage as and when such coverage expires or
      to obtain similar coverage from similar insurers as may be necessary to
      continue its business without a significant increase in cost.

            (q) Transactions With Affiliates and Employees. Except as set forth
      in the SEC Reports, none of the officers or directors of the Company and,
      to the knowledge of the Company, none of the employees of the Company is
      presently a party to any transaction with the Company or any Subsidiary
      (other than for services as employees, officers and directors), including
      any contract, agreement or other arrangement providing for the furnishing
      of services to or by, providing for rental of real or personal property to
      or from, or otherwise requiring payments to or from any officer, director
      or such employee or, to the knowledge of the Company, any entity in which
      any officer, director, or any such employee has a substantial interest or
      is an officer, director, trustee or partner, in each case in excess of
      $60,000 other than (a) for payment of salary or consulting fees for
      services rendered, (b) reimbursement for expenses incurred on behalf of
      the Company and (c) for other employee benefits, including stock option
      agreements under any stock option plan of the Company.

            (r) Internal Accounting Controls. The Company and each of its
      subsidiaries maintains a system of internal accounting controls sufficient
      to provide reasonable assurance that (i) transactions are executed in
      accordance with management's general or specific authorizations, (ii)
      transactions are recorded as necessary to permit preparation of financial
      statements in conformity with GAAP and to maintain asset accountability,
      (iii) access to assets is permitted only in accordance with management's
      general or specific authorization, and (iv) the recorded accountability
      for assets is compared with the existing assets at reasonable intervals
      and appropriate action is taken with respect to any differences. The
      Company has established disclosure controls and procedures (as defined in
      Exchange Act Rules 13a-14 and 15d-14) for the Company and designed such
      disclosures controls and procedures to ensure that material information
      relating to the Company, including its subsidiaries, is made known to the
      certifying officers by others within those entities, particularly during
      the period in which the Company's Form 10-K or 10-Q, as the case may be,
      is being prepared. The Company's certifying officers have evaluated the
      effectiveness of the Company's controls and procedures as of the date
      prior to the filing date of the Form 10-Q for the quarter ended September
      30, 2003 (such date, the "Evaluation Date"). The Company presented in its
      most recently filed Form 10-K or Form 10-Q the conclusions of the
      certifying officers about the effectiveness of the disclosure controls and
      procedures based on their evaluations as of the Evaluation Date. Since the
      Evaluation Date, there have been no significant changes in the Company's
      internal controls (as such term is defined in Item 307(b) of Regulation
      S-K under the Exchange Act) or, to the Company's knowledge, in other
      factors that could significantly affect the Company's internal controls.

            (s) Private Placement. Assuming the accuracy of the Purchasers
      representations and warranties set forth in Section 3.2, no registration
      under the Securities


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      Act is required for the offer and sale of the Securities by the Company to
      the Purchasers as contemplated hereby. The issuance and sale of the
      Securities hereunder does not contravene the rules and regulations of the
      Trading Market.

            (t) Investment Company. The Company is not, and is not an Affiliate
      of, an "investment company" within the meaning of the Investment Company
      Act of 1940, as amended.

            (u) Registration Rights. No Person other than the Purchasers or the
      placement agent of the Securities has any right to cause the Company to
      include in the Registration Statement contemplated by the Registration
      Rights Agreement any other securities of the Company.

            (v) Listing and Maintenance Requirements. The Company has not, in
      the 12 months preceding the date hereof, received notice from any Trading
      Market on which the Common Stock is or has been listed or quoted to the
      effect that the Company is not in compliance with the listing or
      maintenance requirements of such Trading Market. The Company is, and has
      no reason to believe that it will not in the foreseeable future continue
      to be, in compliance with all such listing and maintenance requirements.

            (w) Application of Takeover Protections. The Company and its Board
      of Directors have taken all necessary action, if any, in order to render
      inapplicable any control share acquisition, business combination, poison
      pill (including any distribution under a rights agreement) or other
      similar anti-takeover provision under the Company's Certificate of
      Incorporation (or similar charter documents) or the laws of its state of
      incorporation that is or could become applicable to the Purchasers as a
      result of the Purchasers and the Company fulfilling their obligations or
      exercising their rights under the Transaction Documents, including without
      limitation the Company's issuance of the Securities and the Purchasers'
      ownership of the Securities.

            (x) Disclosure. The Company confirms that, neither the Company nor
      any other Person acting on its behalf has provided any of the Purchasers
      or their agents or counsel with any information that constitutes or might
      constitute material, non-public information. The Company understands and
      confirms that the Purchasers will rely on the foregoing representations
      and covenants in effecting transactions in securities of the Company. All
      disclosure provided to the Purchasers regarding the Company, its business
      and the transactions contemplated hereby, including the Disclosure
      Schedules to this Agreement, furnished by or on behalf of the Company are
      true and correct and do not contain any untrue statement of a material
      fact or omit to state any material fact necessary in order to make the
      statements made therein, in light of the circumstances under which they
      were made, not misleading.

            (y) No Integrated Offering. Neither the Company, nor any of its
      affiliates, nor any Person acting on its or their behalf has, directly or
      indirectly, made any offers or sales of any security or solicited any
      offers to buy any security, under circumstances that would cause this
      offering of the Securities to be integrated with prior offerings by the
      Company for purposes of the Securities Act or any applicable shareholder
      approval provisions, including, without limitation, under the rules and
      regulations of any exchange


                                       11
<PAGE>

      or automated quotation system on which any of the securities of the
      Company are listed or designated.

            (z) Solvency. Based on the financial condition of the Company as of
      the Closing Date, (i) the Company's fair saleable value of its assets
      exceeds the amount that will be required to be paid on or in respect of
      the Company's existing debts and other liabilities (including known
      contingent liabilities) as they mature; (ii) the Company's assets do not
      constitute unreasonably small capital to carry on its business for the
      current fiscal year as now conducted and as proposed to be conducted
      including its capital needs taking into account the particular capital
      requirements of the business conducted by the Company, and projected
      capital requirements and capital availability thereof; and (iii) the
      current cash flow of the Company, together with the proceeds the Company
      would receive, were it to liquidate all of its assets, after taking into
      account all anticipated uses of the cash, would be sufficient to pay all
      amounts on or in respect of its debt when such amounts are required to be
      paid. The Company does not intend to incur debts beyond its ability to pay
      such debts as they mature (taking into account the timing and amounts of
      cash to be payable on or in respect of its debt).

      3.2 Representations and Warranties of the Purchasers. Each Purchaser
hereby, for itself and for no other Purchaser, represents and warrants as of the
date hereof and as of the Closing Date to the Company as follows:

            (a) Organization; Authority. Such Purchaser is an entity duly
      organized, validly existing and in good standing under the laws of the
      jurisdiction of its organization with full right, corporate or partnership
      power and authority to enter into and to consummate the transactions
      contemplated by the Transaction Documents and otherwise to carry out its
      obligations thereunder. The execution, delivery and performance by such
      Purchaser of the transactions contemplated by this Agreement has been duly
      authorized by all necessary corporate action on the part of such
      Purchaser. Each Transaction Document to which it is party has been duly
      executed by such Purchaser, and when delivered by such Purchaser in
      accordance with terms hereof, will constitute the valid and legally
      binding obligation of such Purchaser, enforceable against it in accordance
      with its terms.

            (b) Investment Intent. Such Purchaser understands that the
      Securities are "restricted securities" and have not been registered under
      the Securities Act or any applicable state securities law and is acquiring
      the Securities as principal for its own account for investment purposes
      only and not with a view to or for distributing or reselling such
      Securities or any part thereof, has no present intention of distributing
      any of such Securities and has no arrangement or understanding with any
      other persons regarding the distribution of such Securities (this
      representation and warranty not limiting such Purchaser's right to sell
      the Securities pursuant to the Registration Statement or otherwise in
      compliance with applicable federal and state securities laws). Such
      Purchaser is acquiring the Securities hereunder in the ordinary course of
      its business. Such Purchaser does not have any agreement or understanding,
      directly or indirectly, with any Person to distribute any of the
      Securities.


                                       12
<PAGE>

            (c) Purchaser Status. At the time such Purchaser was offered the
      Securities, it was, and at the date hereof it is an "accredited investor"
      as defined in Rule 501(a) under the Securities Act. Such Purchaser is not
      required to be registered as a broker-dealer under Section 15 of the
      Exchange Act.

            (d) Experience of such Purchaser. Such Purchaser, either alone or
      together with its representatives, has such knowledge, sophistication and
      experience in business and financial matters so as to be capable of
      evaluating the merits and risks of the prospective investment in the
      Securities, and has so evaluated the merits and risks of such investment.
      Such Purchaser is able to bear the economic risk of an investment in the
      Securities and, at the present time, is able to afford a complete loss of
      such investment.

            (e) General Solicitation. Such Purchaser is not purchasing the
      Securities as a result of any advertisement, article, notice or other
      communication regarding the Securities published in any newspaper,
      magazine or similar media or broadcast over television or radio or
      presented at any seminar or any other general solicitation or general
      advertisement.

            (f) Registration Required. Such Purchaser hereby covenants with the
      Company not to make any sale of the Shares and the Warrant without
      complying with the provisions hereof and of the Registration Rights
      Agreement, and without effectively causing the prospectus delivery
      requirement under the Securities Act to be satisfied (unless such
      Purchaser is selling such Shares or Warrant Shares in a transaction not
      subject to the prospectus delivery requirement), and such Purchaser
      acknowledges that the certificates evidencing the Shares and Warrant
      Shares will be imprinted with a legend that prohibits their transfer
      except in accordance therewith.

            (g) No Tax or Legal Advice. Such Purchaser understands that nothing
      in this Agreement, any other Transaction Document or any other materials
      presented to such Purchaser in connection with the purchase and sale of
      the Securities constitutes legal, tax or investment advice. Such Purchaser
      has consulted such legal, tax and investment advisors as it, in its sole
      discretion, has deemed necessary or appropriate in connection with its
      purchase of Securities.

      The Company acknowledges and agrees that each Purchaser does not make or
has not made any representations or warranties with respect to the transactions
contemplated hereby other than those specifically set forth in this Section 3.2.

                                  ARTICLE IV.
                         OTHER AGREEMENTS OF THE PARTIES

      4.1 Transfer Restrictions.

            (a) The Securities may only be disposed of in compliance with state
      and federal securities laws. In connection with any transfer of Securities
      other than pursuant to an effective registration statement, to the
      Company, to an Affiliate of a Purchaser or in connection with a pledge as
      contemplated in Section 4.1(b), the Company may require the transferor
      thereof to provide to the Company an opinion of counsel selected by the
      transferor, the form and substance of which opinion shall be reasonably
      satisfactory to the


                                       13
<PAGE>

      Company, to the effect that such transfer does not require registration of
      such transferred Securities under the Securities Act. As a condition of
      transfer, any such transferee shall agree in writing to be bound by the
      terms of this Agreement and shall have the rights of a Purchaser under
      this Agreement and the Registration Rights Agreement.

            (b) The Purchasers agree to the imprinting, so long as is required
      by this Section 4.1(b), of a legend on any of the Securities in the
      following form:

            THESE SECURITIES HAVE NOT BEEN REGISTERED WITH THE SECURITIES AND
            EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN
            RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES
            ACT OF 1933, AS AMENDED (THE "SECURITIES ACT"), AND, ACCORDINGLY,
            MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE
            REGISTRATION STATEMENT UNDER THE SECURITIES ACT OR PURSUANT TO AN
            AVAILABLE EXEMPTION FROM, OR IN A TRANSACTION NOT SUBJECT TO, THE
            REGISTRATION REQUIREMENTS OF THE SECURITIES ACT AND IN ACCORDANCE
            WITH APPLICABLE STATE SECURITIES LAWS AS EVIDENCED BY A LEGAL
            OPINION OF COUNSEL TO THE TRANSFEROR TO SUCH EFFECT, THE SUBSTANCE
            OF WHICH SHALL BE REASONABLY ACCEPTABLE TO THE COMPANY. THESE
            SECURITIES MAY BE PLEDGED IN CONNECTION WITH A BONA FIDE MARGIN
            ACCOUNT WITH A REGISTERED BROKER-DEALER OR OTHER LOAN WITH A
            FINANCIAL INSTITUTION THAT IS AN "ACCREDITED INVESTOR" AS DEFINED IN
            RULE 501(a) UNDER THE SECURITIES ACT.

            The Company acknowledges and agrees that a Purchaser may from time
      to time pledge pursuant to a bona fide margin agreement with a registered
      broker-dealer or grant a security interest in some or all of the
      Securities to a financial institution that is an "accredited investor" as
      defined in Rule 501(a) under the Securities Act and, if required under the
      terms of such arrangement, such Purchaser may transfer pledged or secured
      Securities to the pledgees or secured parties. Such a pledge or transfer
      would not be subject to approval of the Company and no legal opinion of
      legal counsel of the pledgee, secured party or pledgor shall be required
      in connection therewith. Further, no notice shall be required of such
      pledge. At the appropriate Purchaser's expense, the Company will execute
      and deliver such reasonable documentation as a pledgee or secured party of
      Securities may reasonably request in connection with a pledge or transfer
      of the Securities, including the preparation and filing of any required
      prospectus supplement under Rule 424(b)(3) of the Securities Act or other
      applicable provision of the Securities Act to appropriately amend the list
      of Selling Stockholders thereunder.

            (c) Certificates evidencing the Shares and Warrant Shares shall not
      contain any legend (including the legend set forth in Section 4.1(b)), (i)
      while a registration statement (including the Registration Statement)
      covering the resale of such security is effective under the Securities Act
      (provided, however, that a Purchaser's prospectus delivery requirements
      under the Securities Act and as set forth in Section 3.2(f) will remain
      applicable), or (ii) following any sale of such Shares or Warrant Shares
      pursuant


                                       14
<PAGE>

      to Rule 144, or (iii) if such Shares or Warrant Shares are eligible for
      sale under Rule 144(k), or (iv) if such legend is not required under
      applicable requirements of the Securities Act (including judicial
      interpretations and pronouncements issued by the Staff of the Commission).
      The Company shall cause its counsel to issue a legal opinion to the
      Company's transfer agent promptly after the Effective Date if required by
      the Company's transfer agent to effect the removal of the legend
      hereunder. If all or any portion of a Warrant is exercised at a time when
      there is an effective registration statement to cover the resale of the
      Warrant Shares, such Warrant Shares shall be issued free of all legends.
      The Company agrees that following the Effective Date or at such time as
      such legend is no longer required under this Section 4.1(c), it will, no
      later than five Trading Days following the delivery by a Purchaser to the
      Company or the Company's transfer agent of a certificate representing
      Shares or Warrant Shares, as the case may be, issued with a restrictive
      legend, deliver or cause to be delivered to such Purchaser a certificate
      representing such Securities that is free from all restrictive and other
      legends. The Company may not make any notation on its records or give
      instructions to any transfer agent of the Company that enlarge the
      restrictions on transfer set forth in this Section or in Section 3.2(f).

            (d) In addition to such Purchaser's other available remedies, the
      Company shall pay to a Purchaser, in cash, as liquidated damages and not
      as a penalty, for each $1,000 of Shares or Warrant Shares (based on the
      Closing Price of the Common Stock on the date such Securities are
      submitted to the Company's transfer agent) subject to Section 4.1(c), $5
      per Trading Day (increasing to $10 per Trading Day five (5) Trading Days
      after such damages have begun to accrue) for each Trading Day after the
      seventh (7th) Trading Day following delivery by the Purchaser to the
      Company or the Company's transfer agent of a certificate representing
      Shares or Warrant Shares, as the case may be, issued with a restrictive
      legend, until such certificate is delivered. Nothing herein shall limit
      such Purchaser's right to pursue actual damages for the Company's failure
      to deliver certificates representing any Securities as required by the
      Transaction Documents, and such Purchaser shall have the right to pursue
      all remedies available to it at law or in equity including, without
      limitation, a decree of specific performance and/or injunctive relief.

      4.2 Furnishing of Information. As long as any Purchaser owns Securities,
the Company covenants to timely file (or obtain extensions in respect thereof
and file within the applicable grace period) all reports required to be filed by
the Company after the date hereof pursuant to the Exchange Act. Upon the request
of any such holder of Securities, the Company shall deliver to such holder a
written certification of a duly authorized officer as to whether it has complied
with the preceding sentence. As long as any Purchaser owns Securities, if the
Company is not required to file reports pursuant to such laws, it will prepare
and furnish to the Purchasers and make publicly available in accordance with
Rule 144(c) such information as is required for the Purchasers to sell the
Securities under Rule 144. The Company further covenants that it will take such
further action as any holder of Securities may reasonably request, all to the
extent required from time to time to enable such Person to sell such Securities
without registration under the Securities Act within the limitation of the
exemptions provided by Rule 144.

      4.3 Integration. The Company shall not sell, offer for sale or solicit
offers to buy or otherwise negotiate in respect of any security (as defined in
Section 2 of the Securities Act) that


                                       15
<PAGE>

would be integrated with the offer or sale of the Securities in a manner that
would require the registration under the Securities Act of the sale of the
Securities to the Purchasers or that would be integrated with the offer or sale
of the Securities for purposes of the rules and regulations of any Trading
Market.

      4.4 Securities Laws Disclosure; Publicity. The Company shall, by 8:30 a.m.
Eastern time on the Business Day following the date of this Agreement, issue a
press release or file a Current Report on Form 8-K, in each case reasonably
acceptable to the placement agent of the Securities disclosing the transactions
contemplated hereby and make such other filings and notices in the manner and
time required by the Commission. The Company and the placement agent of the
Securities shall consult with each other in issuing any press releases with
respect to the transactions contemplated hereby, and neither the Company nor any
Purchaser shall issue any such press release or otherwise make any such public
statement without the prior consent of the Company, with respect to any press
release of any Purchaser, or without the prior consent of the placement agent of
the Securities, with respect to any press release of the Company, which consent
shall not unreasonably be withheld, except if such disclosure is required by
law, in which case the disclosing party shall promptly provide the other party
with prior notice of such public statement or communication. Notwithstanding the
foregoing, the Company shall not publicly disclose the name of any Purchaser, or
include the name of any Purchaser in any filing with the Commission or any
regulatory agency or Trading Market, without the prior written consent of such
Purchaser, except (i) as required by federal securities law in connection with
the registration statement contemplated by the Registration Rights Agreement and
(ii) to the extent such disclosure is required by law or Trading Market
regulations, in which case the Company shall provide the Purchasers with prior
notice of such disclosure permitted under subclause (i) or (ii).

      4.5 Shareholders Rights Plan. No claim will be made or enforced by the
Company or any other Person that any Purchaser is an "Acquiring Person" under
any shareholders rights plan or similar plan or arrangement in effect or
hereafter adopted by the Company, or that any Purchaser could be deemed to
trigger the provisions of any such plan or arrangement, by virtue of receiving
Securities under the Transaction Documents or under any other agreement between
the Company and the Purchasers.

      4.6 Non-Public Information. The Company covenants and agrees that neither
it nor any other Person acting on its behalf will provide any Purchaser or its
agents or counsel with any information that the Company believes constitutes
material non-public information, unless prior thereto such Purchaser shall have
executed a written agreement regarding the confidentiality and use of such
information. The Company understands and confirms that each Purchaser shall be
relying on the foregoing representations in effecting transactions in securities
of the Company.

      4.7 Use of Proceeds. Except as set forth on Schedule 4.7 attached hereto,
the Company shall use the net proceeds from the sale of the Securities hereunder
for working capital purposes and not for the satisfaction of any portion of the
Company's debt (other than payment of trade payables in the ordinary course of
the Company's business and prior practices), to redeem any Company equity or
equity-equivalent securities or to settle any outstanding litigation.


                                       16
<PAGE>

      4.8 Indemnification of Purchasers. The Company will indemnify and hold the
Purchasers and their directors, officers, shareholders, partners, employees and
agents (each, a "Purchaser Party") harmless from any and all losses,
liabilities, obligations, claims, contingencies, damages, costs and expenses,
including all judgments, amounts paid in settlements, court costs and reasonable
attorneys' fees and costs of investigation that any such Purchaser Party may
suffer or incur as a result of or relating to: (a) any misrepresentation, breach
or inaccuracy, or any allegation by a third party that, if true, would
constitute a material breach or inaccuracy, of any of the representations,
warranties, covenants or agreements made by the Company in this Agreement or in
the other Transaction Documents; or (b) any cause of action, suit or claim
brought or made against such Purchaser Party and arising solely out of or solely
resulting from the execution, delivery, performance or enforcement of this
Agreement or any of the other Transaction Documents and without causation by any
other activity, obligation, condition or liability pertaining to such Purchaser.
The Company will reimburse such Purchaser for its reasonable legal and other
expenses (including the cost of any investigation, preparation and travel in
connection therewith) incurred in connection therewith, as such expenses are
incurred.

      4.9 Indemnification of the Company. Each Purchaser, severally and not
jointly with the other Purchasers, will indemnify and hold the Company and their
directors, officers, shareholders, partners, employees and agents (each, a
"Company Party") harmless from any and all losses, liabilities, obligations,
claims, contingencies, damages, costs and expenses, including all judgments,
amounts paid in settlements, court costs and reasonable attorneys' fees and
costs of investigation that any such Company Party may suffer or incur as a
result of or relating to any material breach or inaccuracy of any of the
representations, warranties, covenants or agreements made by such Purchaser in
this Agreement or in the other Transaction Documents. Each such Purchaser will
reimburse the Company for its reasonable legal and other expenses (including the
cost of any investigation, preparation and travel in connection therewith)
incurred in connection therewith, as such expenses are incurred.

      4.10 Reservation of Common Stock. As of the date hereof, the Company has
reserved and the Company shall continue to reserve and keep available at all
times, free of preemptive rights, a sufficient number of shares of Common Stock
for the purpose of enabling the Company to issue Shares pursuant to this
Agreement and Warrant Shares pursuant to any exercise of the Warrants.

      4.11 Listing of Common Stock. The Company hereby agrees to use
commercially reasonably efforts to maintain the listing of the Common Stock on
the Trading Market, and as soon as reasonably practicable following the Closing
(but not later than the earlier of the Effective Date and the first anniversary
of the Closing Date) to list the applicable Shares and Warrant Shares on the
Trading Market. The Company further agrees, if the Company applies to have the
Common Stock traded on any other Trading Market, it will include in such
application the Shares and the Warrant Shares, and will take such other action
as is necessary or desirable in the opinion of the Investors to cause the Shares
and Warrant Shares to be listed on such other Trading Market as promptly as
possible. The Company will take all action reasonably necessary to continue the
listing and trading of its Common Stock on a Trading Market and will comply in
all respects with the Company's reporting, filing and other obligations under
the bylaws or rules of the Trading Market.


                                       17
<PAGE>

                                   ARTICLE V.
                                  MISCELLANEOUS

      5.1 Fees and Expenses. Except as otherwise set forth in this Agreement,
each party shall pay the fees and expenses of its advisers, counsel, accountants
and other experts, if any, and all other expenses incurred by such party
incident to the negotiation, preparation, execution, delivery and performance of
this Agreement. The Company shall pay all stamp and other taxes and duties
levied in connection with the sale of the Securities.

      5.2 Entire Agreement. The Transaction Documents, together with the
exhibits and schedules thereto, contain the entire understanding of the parties
with respect to the subject matter hereof and supersede all prior agreements and
understandings, oral or written, with respect to such matters, which the parties
acknowledge have been merged into such documents, exhibits and schedules.

      5.3 Notices. Any and all notices or other communications or deliveries
required or permitted to be provided hereunder shall be in writing and shall be
deemed given and effective on the earliest of (a) the date of transmission, if
such notice or communication is delivered via facsimile at the facsimile number
specified in this Section prior to 6:30 p.m. (New York City time) on a Trading
Day, (b) the next Trading Day after the date of transmission, if such notice or
communication is delivered via facsimile at the facsimile number specified in
this Section on a day that is not a Trading Day or later than 6:30 p.m. (New
York City time) on any Trading Day, (c) the Trading Day following the date of
mailing, if sent by U.S. nationally recognized overnight courier service, or (d)
upon actual receipt by the party to whom such notice is required to be given.
The address for such notices and communications shall be as set forth on the
signature pages attached hereto.

      5.4 Amendments; Waivers. No provision of this Agreement may be waived or
amended except in a written instrument signed, in the case of an amendment, by
the Company , on the one hand, and by those Purchasers (or their transferees)
then holding at least 66% of the Securities not yet sold under the Registration
Statement or under Rule 144, on the other hand. No waiver of any default with
respect to any provision, condition or requirement of this Agreement shall be
deemed to be a continuing waiver in the future or a waiver of any subsequent
default or a waiver of any other provision, condition or requirement hereof, nor
shall any delay or omission of either party to exercise any right hereunder in
any manner impair the exercise of any such right.

      5.5 Construction. The headings herein are for convenience only, do not
constitute a part of this Agreement and shall not be deemed to limit or affect
any of the provisions hereof. The language used in this Agreement will be deemed
to be the language chosen by the parties to express their mutual intent, and no
rules of strict construction will be applied against any party.

      5.6 Successors and Assigns. This Agreement shall be binding upon and inure
to the benefit of the parties and their successors and permitted assigns. The
Company may not assign this Agreement or any rights or obligations hereunder
without the prior written consent of those


                                       18
<PAGE>

Purchasers (or their transferees) then holding at least 66% of the Securities
not yet sold under the Registration Statement or under Rule 144. Any Purchaser
may assign any or all of its rights under this Agreement to any Person to whom
such Purchaser assigns or transfers any Securities, provided such transferee
agrees in writing to be bound, with respect to the transferred Securities, by
the provisions hereof that apply to the "Purchasers", including without
limitation, the representations and warranties as to such transferee's status as
an "accredited investor" under the Securities Act.

      5.7 No Third-Party Beneficiaries. This Agreement is intended for the
benefit of the parties hereto and their respective successors and permitted
assigns and is not for the benefit of, nor may any provision hereof be enforced
by, any other Person, except as otherwise set forth in Section 4.8.

      5.8 Governing Law. All questions concerning the construction, validity,
enforcement and interpretation of the Transaction Documents shall be governed by
and construed and enforced in accordance with the internal laws of the State of
New York, without regard to the principles of conflicts of law thereof. Each
party agrees that all legal proceedings concerning the interpretations,
enforcement and defense of the transactions contemplated by this Agreement and
any other Transaction Documents (whether brought against a party hereto or its
respective affiliates, directors, officers, shareholders, employees or agents)
shall be commenced exclusively in the state and federal courts sitting in the
City of New York. Each party hereto hereby irrevocably submits to the exclusive
jurisdiction of the state and federal courts sitting in the City of New York,
New York for the adjudication of any dispute hereunder or in connection herewith
or with any transaction contemplated hereby or discussed herein (including with
respect to the enforcement of the any of the Transaction Documents), and hereby
irrevocably waives, and agrees not to assert in any suit, action or proceeding,
any claim that it is not personally subject to the jurisdiction of any such
court, that such suit, action or proceeding is improper. Each party hereto
hereby irrevocably waives personal service of process and consents to process
being served in any such suit, action or proceeding by mailing a copy thereof
via registered or certified mail or overnight delivery (with evidence of
delivery) to such party at the address in effect for notices to it under this
Agreement and agrees that such service shall constitute good and sufficient
service of process and notice thereof. Nothing contained herein shall be deemed
to limit in any way any right to serve process in any manner permitted by law.
Each party hereto (including its affiliates, agents, officers, directors and
employees) hereby irrevocably waives, to the fullest extent permitted by
applicable law, any and all right to trial by jury in any legal proceeding
arising out of or relating to this Agreement or the transactions contemplated
hereby.

      5.9 Survival. The representations, warranties, agreements and covenants
contained herein shall survive the Closing and delivery of the Shares and
Warrant Shares.

      5.10 Execution. This Agreement may be executed in two or more
counterparts, all of which when taken together shall be considered one and the
same agreement and shall become effective when counterparts have been signed by
each party and delivered to the other party, it being understood that both
parties need not sign the same counterpart. In the event that any signature is
delivered by facsimile transmission, such signature shall create a valid and
binding obligation of the party executing (or on whose behalf such signature is
executed) with the same force and effect as if such facsimile signature page
were an original thereof.


                                       19
<PAGE>

      5.11 Severability. If any provision of this Agreement is held to be
invalid or unenforceable in any respect, the validity and enforceability of the
remaining terms and provisions of this Agreement shall not in any way be
affected or impaired thereby and the parties will attempt to agree upon a valid
and enforceable provision that is a reasonable substitute therefor, and upon so
agreeing, shall incorporate such substitute provision in this Agreement.

      5.12 Replacement of Securities. If any certificate or instrument
evidencing any Securities is mutilated, lost, stolen or destroyed, the Company
shall issue or cause to be issued in exchange and substitution for and upon
cancellation thereof, or in lieu of and substitution therefor, a new certificate
or instrument, but only upon receipt of evidence reasonably satisfactory to the
Company of such loss, theft or destruction and customary and reasonable
indemnity, if requested. The applicants for a new certificate or instrument
under such circumstances shall also pay any reasonable third-party costs
associated with the issuance of such replacement Securities.

      5.13 Remedies. In addition to being entitled to exercise all rights
provided herein or granted by law, including recovery of damages, each of the
Purchasers and the Company will be entitled to specific performance under the
Transaction Documents. The parties agree that monetary damages may not be
adequate compensation for any loss incurred by reason of any breach of
obligations described in the foregoing sentence and hereby agrees to waive in
any action for specific performance of any such obligation the defense that a
remedy at law would be adequate.

      5.14 Payment Set Aside. To the extent that the Company makes a payment or
payments to any Purchaser pursuant to any Transaction Document or a Purchaser
enforces or exercises its rights thereunder, and such payment or payments or the
proceeds of such enforcement or exercise or any part thereof are subsequently
invalidated, declared to be fraudulent or preferential, set aside, recovered
from, disgorged by or are required to be refunded, repaid or otherwise restored
to the Company, a trustee, receiver or any other person under any law
(including, without limitation, any bankruptcy law, state or federal law, common
law or equitable cause of action), then to the extent of any such restoration
the obligation or part thereof originally intended to be satisfied shall be
revived and continued in full force and effect as if such payment had not been
made or such enforcement or setoff had not occurred.

      5.15 Independent Nature of Purchasers' Obligations and Rights. The
obligations of each Purchaser under any Transaction Document are several and not
joint with the obligations of any other Purchaser, and no Purchaser shall be
responsible in any way for the performance of the obligations of any other
Purchaser under any Transaction Document. Nothing contained herein or in any
Transaction Document, and no action taken by any Purchaser pursuant thereto,
shall be deemed to constitute the Purchasers as a partnership, an association, a
joint venture or any other kind of entity, or create a presumption that the
Purchasers are in any way acting in concert or as a group with respect to such
obligations or the transactions contemplated by the Transaction Document. Each
Purchaser shall be entitled to independently protect and enforce its rights,
including without limitation, the rights arising out of this Agreement or out of
the other Transaction Documents, and it shall not be necessary for any other
Purchaser to be joined as an additional party in any proceeding for such
purpose. Each Purchaser has been represented by its own separate legal counsel
in their review and negotiation of the Transaction Documents. For reasons of
administrative convenience only, Purchasers and their respective counsel have
chosen


                                       20
<PAGE>

to communicate with the Company through Feldman Weinstein LLP. Feldman Weinstein
LLP does not represent the Purchasers in this transaction but only Rodman &
Renshaw, Inc., the placement agent that introduced the Company to the
Purchasers. The Company has elected to provide all Purchasers with the same
terms and Transaction Documents for the convenience of the Company and not
because it was required or requested to do so by the Purchasers.

                            (Signature Page Follows)


                                       21
<PAGE>

            IN WITNESS WHEREOF, the parties hereto have caused this Securities
Purchase Agreement to be duly executed by their respective authorized
signatories as of the date first indicated above.

AXONYX, INC.                               Address for Notice:
                                           500 Seventh Avenue, 10th Floor
                                           New York, NY 10018
By:_____________________________________   Attn:
   Name:                                   Tel: (212)
   Title:                                  Fax: (212)

With copy to (which shall not constitute notice):

Ehrenreich Eilenberg & Krause LLP
11 East 44th Street, 17th Floor
New York, New York 10017
Attn: Adam D. Eilenberg, Esq.
Tel: (212) 986-9700
Fax: (212) 986-2399

                      [PURCHASERS' SIGNATURE PAGES FOLLOW]


                                       22
<PAGE>

          [PURCHASER SIGNATURE PAGES TO SECURITIES PURCHASE AGREEMENT]

PURCHASER:


By: _______________________________
Name:
Title:

Shares of Common Stock:
Warrants:
Aggregate Purchase Price @$5.15 per Share and $0.125 per Warrant: $

Address for Notice:

Tax ID No. (if applicable)_________________________

                      [PURCHASERS' SIGNATURE PAGES FOLLOW]


                                       23
<PAGE>

          [PURCHASER SIGNATURE PAGES TO SECURITIES PURCHASE AGREEMENT]

PURCHASER:  ALEXANDRA GLOBAL MASTER FUND LTD.
BY:         ALEXANDRA INVESTMENT MANAGEMENT, LLC


By:  /s/ Vadim Iosilevich
     ------------------------------
Name:    Vadim Iosilevich
Title:   Principal

Shares of Common Stock: 482,509
Warrants: 120,627
Aggregate Purchase Price @$5.15 per Share and $0.125 per Warrant: $2,500,000.00

Address for Notice:
Alexandra Investment Management, LLC
767 Third Avenue, 39th Floor
New York, NY 10017

Tax ID No. (if applicable)_________________________

[PURCHASERS' SIGNATURE PAGES FOLLOW]


                                       24
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          [PURCHASER SIGNATURE PAGES TO SECURITIES PURCHASE AGREEMENT]

PURCHASER: ASSET MANAGEMENT


By:    /s/ Kellie Seringer
       ----------------------------
Name:  Kellie Seringer
Title: General Partner

Shares of Common Stock: 38,964
Warrants: 9,741
Aggregate Purchase Price @$5.15 per Share and $0.125 per Warrant: $

Address for Notice:
Symmetry Capital Management LLC
One Montgomery Street
Suite 3300
San Francisco, CA 94104

Tax ID No. (if applicable) 11-3471306

[PURCHASERS' SIGNATURE PAGES FOLLOW]


                                       25
<PAGE>

          [PURCHASER SIGNATURE PAGES TO SECURITIES PURCHASE AGREEMENT]

PURCHASER: ATLAS FUND, LLC


By:    /s/ Scott H. Schroeder
       -----------------------------------
Name:  Scott H. Schroeder
Title: Managing Director of Finance
       General Counsel

Shares of Common Stock: 500,000
Warrants: 125,000
Aggregate Purchase Price @$5.15 per Share and $0.125 per Warrant: $2,590,625.00

Address for Notice:
c/o BAM, LLC
181 W Madison, Ste 3600
Chicago, IL 60602

Tax ID No. (if applicable)_________________________

[PURCHASERS' SIGNATURE PAGES FOLLOW]


                                       26
<PAGE>

          [PURCHASER SIGNATURE PAGES TO SECURITIES PURCHASE AGREEMENT]

PURCHASER: BAYSTAR CAPITAL II, LP


By:    /s/ Steve Derby
       ----------------------------
Name:  Steve Derby
Title: Managing Member

Shares of Common Stock: 289,505
Warrants: 72,376
Aggregate Purchase Price @$5.15 per Share and $0.125 per Warrant: $1,499,997.75

Address for Notice:
BayStar Capital II, LP
C/o BayStar Capital Management, LLC
80 E. Sir Francis Drake Blvd., Suite 2B
Larkspur, California 94939
Attn: Steven Lamar

Tax ID No. (if applicable) 94-3408990

[PURCHASERS' SIGNATURE PAGES FOLLOW]


                                       27
<PAGE>

          [PURCHASER SIGNATURE PAGES TO SECURITIES PURCHASE AGREEMENT]

PURCHASER: BRISTOL INVESTMENT FUND, LTD.


By:    /s/ Paul Kessler
       ----------------------------
Name:  Paul Kessler
Title: Director

Shares of Common Stock: 96,502
Warrants: 24,125
Aggregate Purchase Price @$5.15 per Share and $0.125 per Warrant: $500,000.00

Address for Notice:

Bristol Capital Advisors, LLC
6363 Sunset Blvd, 5th Floor
Hollywood, CA 90028
Attn: Amy Wang, Esq.

Tax ID No. (if applicable) 98-0335509

[PURCHASERS' SIGNATURE PAGES FOLLOW]


                                       28
<PAGE>

          [PURCHASER SIGNATURE PAGES TO SECURITIES PURCHASE AGREEMENT]

PURCHASER: CAPITAL VENTURES INTERNATIONAL


By:    /s/ Martin Kobinger
       ----------------------------
Name:  Martin Kobinger
Title: Investment Manager

Shares of Common Stock: 193,004
Warrants: 48,251
Aggregate Purchase Price @$5.15 per Share and $0.125 per Warrant: $1,000,000.00

Address for Notice:
Heights Capital Management
425 California Street, Suite 1100
San Francisco, CA 94104

Tax ID No. (if applicable) 98-0335509

[PURCHASERS' SIGNATURE PAGES FOLLOW]


                                       29
<PAGE>

          [PURCHASER SIGNATURE PAGES TO SECURITIES PURCHASE AGREEMENT]

PURCHASER: CASTLE CREEK HEALTHCARE PARTNERS LLC


By:    /s/ Thomas A. Frei
       ----------------------------
Name:  Thomas A. Frei
Title: Managing Director of the
       Investment Manager

Shares of Common Stock: 96,502
Warrants: 24,125
Aggregate Purchase Price @$5.15 per Share and $0.125 per Warrant: $

Address for Notice:
c/o Castle Creek Partners, LLC
Attn: Thomas A. Frei
111 West Jackson Blvd., Suite 2020
Chicago, IL 60604

Tax ID No. (if applicable) 52-2137654

[PURCHASERS' SIGNATURE PAGES FOLLOW]


                                       30
<PAGE>

          [PURCHASER SIGNATURE PAGES TO SECURITIES PURCHASE AGREEMENT]

PURCHASER: COHANZICK PARTNERS, LP


By:    /s/ David K, Sherman
       ----------------------------
Name:  David K. Sherman
Title: Authorized Agent

Shares of Common Stock: 26,000
Warrants: 6,500
Aggregate Purchase Price @$5.15 per Share and $0.125 per Warrant: $134,712.50

Address for Notice:
David K. Sherman
Cohenzick Partners, LP
427 Bedford Road
Suite 260
Pleasantville, NY 10570

Tax ID No. (if applicable) 52-2014699

[PURCHASERS' SIGNATURE PAGES FOLLOW]


                                       31
<PAGE>

          [PURCHASER SIGNATURE PAGES TO SECURITIES PURCHASE AGREEMENT]

PURCHASER: CRANSHIRE CAPITAL, L.P.


By:    /s/ Keith Goodman
       ----------------------------
Name:  Keith Goodman
Title: CFO, Counselor Capital, LP
       The General Partner

Shares of Common Stock: 386.007
Warrants: 96,502
Aggregate Purchase Price @$5.15 per Share and $0.125 per Warrant:

Address for Notice:
Attn: Mitchell Kopin
666 Dundee Road
Suite 1901
Northbrook, IL 60062

Tax ID No. (if applicable) 36-4055954

[PURCHASERS' SIGNATURE PAGES FOLLOW]


                                       32
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          [PURCHASER SIGNATURE PAGES TO SECURITIES PURCHASE AGREEMENT]

PURCHASER: CRESCENT INTERNATIONAL LTD.


By:    /s/ Mel Craw    /s/ Maxi Breon
       -------------------------------
Name:  Mel Craw ; Maxi Breon
Title: Authorized Signatories

Shares of Common Stock: 80,000
Warrants: 20,000
Aggregate Purchase Price @$5.15 per Share and $0.125 per Warrant: $414,500

Address for Notice:
GreenLight (Switzerland) SA
84, Avenue Louis-Casai
CH 1216 Cointrin, Geneva Switzerland

Tax ID No. (if applicable) N/A

[PURCHASERS' SIGNATURE PAGES FOLLOW]


                                       33
<PAGE>

          [PURCHASER SIGNATURE PAGES TO SECURITIES PURCHASE AGREEMENT]

PURCHASER: DKR SATURN EVENT DRIVEN HOLDING FUND LTD.


By: /s/ Anthony Giordano
    -------------------------------
Name:   Anthony Giordano
Title:  Authorized Signatory

Shares of Common Stock: 166,700
Warrants: 41,675
Aggregate Purchase Price @$5.15 per Share and $0.125 per Warrant: $863,714.37

Address for Notice:
DKR Capital Partners L.P.
1281 East Main Street
Stamford, CT 06902

Tax ID No. (if applicable) 98-0375457

[PURCHASERS' SIGNATURE PAGES FOLLOW]


                                       34
<PAGE>

          [PURCHASER SIGNATURE PAGES TO SECURITIES PURCHASE AGREEMENT]

PURCHASER: DKR SATURN HOLDING FUND LTD.


By:    /s/ Anthony Giordano
       ----------------------------
Name:  Anthony Giordano
Title: Authorized Signatory

Shares of Common Stock: 33,300
Warrants: 8,325
Aggregate Purchase Price @$5.15 per Share and $0.125 per Warrant: $172,535.62

Address for Notice:
DKR Capital Partners L.P.
1281 East Main Street
Stamford, CT 06902

Tax ID No. (if applicable) 98-0374858

[PURCHASERS' SIGNATURE PAGES FOLLOW]


                                       35
<PAGE>

          [PURCHASER SIGNATURE PAGES TO SECURITIES PURCHASE AGREEMENT]

PURCHASER: ELLIOT ASSOCIATES, L.P.


By:    /s/ Elliot Greenberg
       ----------------------------
Name:  Elliot Greenberg
Title: Vice President

Shares of Common Stock: 115,802
Warrants: 28,950
Aggregate Purchase Price @$5.15 per Share and $0.125 per Warrant: $599,999.05

Address for Notice:
Attn: Elliot Greenberg
c/o Elliot Management Corp
712 Fifth Avenue
New York, NY 10019

Tax ID No. (if applicable) 22-2140975

[PURCHASERS' SIGNATURE PAGES FOLLOW]


                                       36
<PAGE>

          [PURCHASER SIGNATURE PAGES TO SECURITIES PURCHASE AGREEMENT]

PURCHASER: ELLIOT INTERNATIONAL, L.P.


By:    /s/ Elliot Greenberg
       ----------------------------
Name:  Elliot Greenberg
Title: Vice President

Shares of Common Stock: 173,703
Warrants: 43,426
Aggregate Purchase Price @$5.15 per Share and $0.125 per Warrant: $899,998.70

Address for Notice:
Attn: Elliot Greenberg
c/o Elliot Management Corp
712 Fifth Avenue
New York, NY 10019

Tax ID No. (if applicable) N/A

[PURCHASERS' SIGNATURE PAGES FOLLOW]


                                       37
<PAGE>

          [PURCHASER SIGNATURE PAGES TO SECURITIES PURCHASE AGREEMENT]

PURCHASER: EPSILON GLOBAL ASSET MANAGEMENT LTD-GP


By:    /s/ Steve Stevanovich
       ----------------------------
Name:  Steve Stevanovich
Title: President

Shares of Common Stock: 50,000
Warrants: 12,500
Aggregate Purchase Price @$5.15 per Share and $0.125 per Warrant: $259,062.50

Address for Notice:
7280 W. Palmetto Park Road
Suite 310
Boca Raton, FL 33433

Tax ID No. (if applicable) N/A Foreign

[PURCHASERS' SIGNATURE PAGES FOLLOW]


                                       38
<PAGE>

          [PURCHASER SIGNATURE PAGES TO SECURITIES PURCHASE AGREEMENT]

PURCHASER: FIPS HEALTH FUND


By:    /s/ Bill Kennedy
       ----------------------------
Name:  Bill Kennedy
Title: Treasury Manager, Framlington Investment Management

Shares of Common Stock: 40,000
Warrants: 10,000
Aggregate Purchase Price @$5.15 per Share and $0.125 per Warrant:

Address for Notice:

BBH 140 Broadway
A/C 1596055
A/C CAI LUX

Tax ID No. (if applicable) N/A

[PURCHASERS' SIGNATURE PAGES FOLLOW]


                                       39
<PAGE>

          [PURCHASER SIGNATURE PAGES TO SECURITIES PURCHASE AGREEMENT]

PURCHASER: FIRST NEW YORK SECURITIES LLC


By:    /s/ Harris Sufian
       ----------------------------
Name:  Harris Sufian
Title: Managing Member

Shares of Common Stock: 85,000
Warrants: 21,250
Aggregate Purchase Price @$5.15 per Share and $0.125 per Warrant:

Address for Notice:

C/o First New York Securities LLC
850 3rd Avenue, 17th Floor
NYC, NY 10022

Tax ID No. (if applicable) 13-3270745

[PURCHASERS' SIGNATURE PAGES FOLLOW]


                                       40
<PAGE>

          [PURCHASER SIGNATURE PAGES TO SECURITIES PURCHASE AGREEMENT]

PURCHASER: FNY CARPEDIEM II L.P.


By:    /s/ Harris Sufian
       ----------------------------
Name:  Harris Sufian
Title: Member

Shares of Common Stock: 92,450
Warrants: 23,113
Aggregate Purchase Price @$5.15 per Share and $0.125 per Warrant:

Address for Notice:

C/o First New York Securities LLC
850 3rd Avenue, 17th Floor
NYC, NY 10022

Tax ID No. (if applicable) 13-4149330

[PURCHASERS' SIGNATURE PAGES FOLLOW]


                                       41
<PAGE>

          [PURCHASER SIGNATURE PAGES TO SECURITIES PURCHASE AGREEMENT]

PURCHASER: FNY CARPEDIEM OFFSHORE LTD.


By:    /s/ Michael Friedman
       ----------------------------
Name:  Michael Friedman
Title: Director

Shares of Common Stock: 51,600
Warrants: 12,900
Aggregate Purchase Price @$5.15 per Share and $0.125 per Warrant:

Address for Notice:

FNY Carpediem Offshore Ltd.
PO Box 32021 SMB Anchorage Center
2nd Floor
Georgetown, Caymen Islands

Tax ID No. (if applicable) N/A

[PURCHASERS' SIGNATURE PAGES FOLLOW]


                                       42
<PAGE>

          [PURCHASER SIGNATURE PAGES TO SECURITIES PURCHASE AGREEMENT]

PURCHASER: FNY CARPEDIEM PARTNERS L.P.


By:    /s/ Harris Sufian
       ----------------------------
Name:  Harris Sufian
Title: Member

Shares of Common Stock: 70,950
Warrants: 17,738
Aggregate Purchase Price @$5.15 per Share and $0.125 per Warrant:

Address for Notice:
C/o First New York Securities LLC
850 3rd Avenue, 17th Floor
NYC, NY 10022

Tax ID No. (if applicable) 13-3937456

[PURCHASERS' SIGNATURE PAGES FOLLOW]


                                       43
<PAGE>

          [PURCHASER SIGNATURE PAGES TO SECURITIES PURCHASE AGREEMENT]

PURCHASER: FRAMLINGTON BIOTECH FUND


By:    /s/ Bill Kennedy
       ----------------------------
Name:  Bill Kennedy
Title: Treasury Manager, Framlington Investment Management

Shares of Common Stock: 110,000
Warrants: 27,500
Aggregate Purchase Price @$5.15 per Share and $0.125 per Warrant:

Address for Notice:
HSBC Global Investor Services
Mariner House
Pepys Street
London EC3N 4DA

Tax ID No. (if applicable) N/A

[PURCHASERS' SIGNATURE PAGES FOLLOW]


                                       44
<PAGE>

          [PURCHASER SIGNATURE PAGES TO SECURITIES PURCHASE AGREEMENT]

PURCHASER: FRAMLINGTON HEALTH FUND


By:    /s/ Bill Kennedy
       ----------------------------
Name:  Bill Kennedy
Title: Treasury Manager, Framlington Investment Management

Shares of Common Stock: 700,000
Warrants: 175,000
Aggregate Purchase Price @$5.15 per Share and $0.125 per Warrant:

Address for Notice:
HSBC Global Investor Services
Mariner House
Pepys Street
London EC3N 4DA

Tax ID No. (if applicable) N/A

[PURCHASERS' SIGNATURE PAGES FOLLOW]


                                       45
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          [PURCHASER SIGNATURE PAGES TO SECURITIES PURCHASE AGREEMENT]

PURCHASER: GABRIEL CAPITAL, L.P.


By:    /s/ David K, Sherman
       ----------------------------
Name:  David K. Sherman
Title: Authorized Agent

Shares of Common Stock: 70,502
Warrants: 17,625
Aggregate Purchase Price @$5.15 per Share and $0.125 per Warrant: $365,287.50

Address for Notice:
Gabriel Capital Group
450 Park Avenue
Suite 3201
New York, NY 10022
Attn: Michael Autera

Tax ID No. (if applicable) 13-3621277

[PURCHASERS' SIGNATURE PAGES FOLLOW]


                                       46
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          [PURCHASER SIGNATURE PAGES TO SECURITIES PURCHASE AGREEMENT]

PURCHASER: GALLEON CAPTAIN'S OFFSHORE, LTD.


By:    /s/ George Lau
       ----------------------------
Name:  George Lau
Title: Managing Director

Shares of Common Stock: 235,000
Warrants: 58,750
Aggregate Purchase Price @$5.15 per Share and $0.125 per Warrant: $1,217,593.75

Address for Notice:

135 East 57th Street, 16th Floor
New York, NY 10022
Attn: George Lau

Tax ID No. (if applicable) N/A

[PURCHASERS' SIGNATURE PAGES FOLLOW]


                                       47
<PAGE>

          [PURCHASER SIGNATURE PAGES TO SECURITIES PURCHASE AGREEMENT]

PURCHASER: GALLEON CAPTAIN'S PARTNERS, LP.


By:    /s/ George Lau
       ----------------------------
Name:  George Lau
Title: Managing Director

Shares of Common Stock: 65,000
Warrants: 16,250
Aggregate Purchase Price @$5.15 per Share and $0.125 per Warrant: $336,781.25

Address for Notice:

135 East 57th Street, 16th Floor
New York, NY 10022
Attn: George Lau

Tax ID No. (if applicable) 76-0724776

[PURCHASERS' SIGNATURE PAGES FOLLOW]


                                       48
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          [PURCHASER SIGNATURE PAGES TO SECURITIES PURCHASE AGREEMENT]

PURCHASER: GALLEON HEALTHCARE OFFSHORE, LTD.


By:    /s/ George Lau
       ----------------------------
Name:  George Lau
Title: Managing Director

Shares of Common Stock: 435,000
Warrants: 108,750
Aggregate Purchase Price @$5.15 per Share and $0.125 per Warrant: $2,253,843.75

Address for Notice:

135 East 57th Street, 16th Floor
New York, NY 10022
Attn: George Lau

Tax ID No. (if applicable) N/A

[PURCHASERS' SIGNATURE PAGES FOLLOW]


                                       49
<PAGE>

          [PURCHASER SIGNATURE PAGES TO SECURITIES PURCHASE AGREEMENT]

PURCHASER: GALLEON HEALTHCARE PARTNERS, LP.


By:    /s/ George Lau
       ----------------------------
Name:  George Lau
Title: Managing Director

Shares of Common Stock: 65,000
Warrants: 16,250
Aggregate Purchase Price @$5.15 per Share and $0.125 per Warrant: $336,781.35

Address for Notice:

135 East 57th Street, 16th Floor
New York, NY 10022
Attn: George Lau

Tax ID No. (if applicable) 13-3936973

[PURCHASERS' SIGNATURE PAGES FOLLOW]


                                       50
<PAGE>

          [PURCHASER SIGNATURE PAGES TO SECURITIES PURCHASE AGREEMENT]

PURCHASER: LANGLEY PARTNERS, L.P.


By:    /s/ Jeffrey Thorp
       ----------------------------
Name:  Jeffrey Thorp
Title: Managing Member of Langley Capital, LLC
       General Partner

Shares of Common Stock:
Warrants:
Aggregate Purchase Price @$5.15 per Share and $0.125 per Warrant: $1,500,000.00

Address for Notice:

c/o Langley Capital, LLC
535 Madison Avenue, 7th Floor
New York, NY 10022

Tax ID No. (if applicable) 38-3325060

[PURCHASERS' SIGNATURE PAGES FOLLOW]


                                       51
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          [PURCHASER SIGNATURE PAGES TO SECURITIES PURCHASE AGREEMENT]

PURCHASER: MUNDER FRAMLINGTON HEALTHCARE FUND


By:    /s/ Bill Kennedy
       ----------------------------
Name:  Bill Kennedy
Title: Treasury Manager, Framlington Investment Management

Shares of Common Stock: 210,000
Warrants: 52,500
Aggregate Purchase Price @$5.15 per Share and $0.125 per Warrant:

Address for Notice:

State St Corp
Concourse Level
Boston, MA 02110

Tax ID No. (if applicable) 38-3325060

[PURCHASERS' SIGNATURE PAGES FOLLOW]


                                       52
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          [PURCHASER SIGNATURE PAGES TO SECURITIES PURCHASE AGREEMENT]

PURCHASER: NORTH SOUND LEGACY FUND LLC


By:    /s/ Andrew Wilder
       ----------------------------
Name:  Andrew Wilder
Title: Chief Financial Officer

Shares of Common Stock: 13,508
Warrants: 3,377
Aggregate Purchase Price @$5.15 per Share and $0.125 per Warrant: $69,988.33

Address for Notice:
North Sound Legacy Fund LLC
c/o North Sound Capital LLC
53 Forest Avenue, Suite 202
Old Greenwich, CT 06870

Tax ID No. (if applicable) 52-2324838

[PURCHASERS' SIGNATURE PAGES FOLLOW]


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          [PURCHASER SIGNATURE PAGES TO SECURITIES PURCHASE AGREEMENT]

PURCHASER: NORTH SOUND LEGACY INSTITUTIONAL FUND LLC


By:    /s/ Andrew Wilder
       ----------------------------
Name:  Andrew Wilder
Title: Chief Financial Officer

Shares of Common Stock: 137,032
Warrants: 34,258
Aggregate Purchase Price @$5.15 per Share and $0.125 per Warrant: $709,997.05

Address for Notice:
North Sound Legacy Fund LLC
c/o North Sound Capital LLC
53 Forest Avenue, Suite 202
Old Greenwich, CT 06870

Tax ID No. (if applicable) 06-1627435

[PURCHASERS' SIGNATURE PAGES FOLLOW]


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          [PURCHASER SIGNATURE PAGES TO SECURITIES PURCHASE AGREEMENT]

PURCHASER: NORTH SOUND LEGACY INTERNATIONAL LTD.


By:    /s/ Andrew Wilder
       ----------------------------
Name:  Andrew Wilder
Title: Chief Financial Officer

Shares of Common Stock: 235,468
Warrants: 58,867
Aggregate Purchase Price @$5.15 per Share and $0.125 per Warrant: $1,220,018.58

Address for Notice:
North Sound Legacy International Ltd.
c/o North Sound Capital LLC
53 Forest Avenue, Suite 202
Old Greenwich, CT 06870
Attn: Andrew Wilder, CFO

Tax ID No. (if applicable) N/A - Non U.S. Entity

[PURCHASERS' SIGNATURE PAGES FOLLOW]


                                       55
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          [PURCHASER SIGNATURE PAGES TO SECURITIES PURCHASE AGREEMENT]

PURCHASER: OMICRON MASTER TRUST


By:    /s/ Olivier Morali
       ----------------------------
Name:  Olivier Morali
Title: President

Shares of Common Stock: 321,782
Warrants: 80,446
Aggregate Purchase Price @$5.15 per Share and $0.125 per Warrant: $1,667,232.99

Address for Notice:

c/o Langley Capital, LLC
535 Madison Avenue, 7th Floor
New York, NY 10022

Tax ID No. (if applicable) 98-6053436

[PURCHASERS' SIGNATURE PAGES FOLLOW]


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          [PURCHASER SIGNATURE PAGES TO SECURITIES PURCHASE AGREEMENT]

PURCHASER: OTAPE INVESTMENTS LLC


By:    /s/ J. Santom
       ----------------------------
Name:  J. Santom
Title: CFO

Shares of Common Stock: 19,300
Warrants: 4,825
Aggregate Purchase Price @$5.15 per Share and $0.125 per Warrant: $100,000.00

Address for Notice:
OTAPE Investments LLC
1 Manhattanville Rd, Suite 102
Purchase, NY 10577
Attn: Vinny Digeso

Tax ID No. (if applicable) 52-2153962

[PURCHASERS' SIGNATURE PAGES FOLLOW]


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          [PURCHASER SIGNATURE PAGES TO SECURITIES PURCHASE AGREEMENT]

PURCHASER: PORTSIDE GROWTH and OPPORTUNITY FUND


By:    /s/ Jeff Smith
       ----------------------------
Name:  Jeff Smith
Title: Authorized Signatory

Shares of Common Stock: 400,000
Warrants: 100,000
Aggregate Purchase Price @$5.15 per Share and $0.125 per Warrant: $2,072,500.00

Address for Notice:

c/o Ramius Capital Group, LLC
666 Third Avenue, 26th Floor
New York, NY 10017

Tax ID No. (if applicable) 98-0216878

[PURCHASERS' SIGNATURE PAGES FOLLOW]


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          [PURCHASER SIGNATURE PAGES TO SECURITIES PURCHASE AGREEMENT]

PURCHASER: RHP MASTER FUND, LTD.


By:    /s/ Keith S. Marlowe
       ----------------------------
Name:  Keith S. Marlowe
Title: Director

Shares of Common Stock: 96,502
Warrants: 24,125
Aggregate Purchase Price @$5.15 per Share and $0.125 per Warrant: $500,000.00

Address for Notice:
c/o Rock Hill Investmnt Mgmt, L.P.
3 Bala Plaza - East, Suite 585
Bala Cynwyd, PA 19004
Attn: Legal Department

Tax ID No. (if applicable) ________________________

[PURCHASERS' SIGNATURE PAGES FOLLOW]


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          [PURCHASER SIGNATURE PAGES TO SECURITIES PURCHASE AGREEMENT]

PURCHASER: SAC CAPITAL ASSOCIATES, LLC


By:    /s/ Pete Nussbaum
       ----------------------------
Name:  Pete Nussbaum
Title: General Counsel

Shares of Common Stock: 600,000
Warrants: 150,000
Aggregate Purchase Price @$5.15 per Share and $0.125 per Warrant: $3,108,750

Address for Notice:

c/o S.A.C. Capital Advisors, LLC
72 Cummings Point Road
Stamford, CT 06902

Tax ID No. (if applicable) ________________________

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PURCHASER: SMITHFIELD FIDUCIARY LLC


By:    /s/ Adam J. Chill
       ----------------------------
Name:  Adam J. Chill
Title: Authorized Signatory

Shares of Common Stock: 579,010
Warrants: 144,753
Aggregate Purchase Price @$5.15 per Share and $0.125 per Warrant: $2,999,995.63

Address for Notice:

c/o Highbridge Capital Mgt, LLC
9 West 57th Street, 27th Flr
New York, NY 10019

Tax ID No. (if applicable) ________________________

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PURCHASER: SYMMETRY CAPITAL OFFSHORE FUND LTD


By:    /s/ Kellie Seringer
       ----------------------------
Name:  Kellie Seringer
Title: General Partner

Shares of Common Stock: 7,755
Warrants: 1,939
Aggregate Purchase Price @$5.15 per Share and $0.125 per Warrant: $

Address for Notice:
Symmetry Capital Management LLC
One Montgomery Street
Suite 3300
San Francisco, CA 94104

Tax ID No. (if applicable) N/A

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PURCHASER: SYMMETRY CAPITAL PARTNERS, L.P.


By:    /s/ Kellie Seringer
       ----------------------------
Name:  Kellie Seringer
Title: General Partner

Shares of Common Stock: 20,410
Warrants: 5,103
Aggregate Purchase Price @$5.15 per Share and $0.125 per Warrant: $

Address for Notice:
Symmetry Capital Management LLC
One Montgomery Street
Suite 3300
San Francisco, CA 94104

Tax ID No. (if applicable) 94-3403890

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PURCHASER: SYMMETRY CAPITAL QUALIFIED PARTNERS, L.P.


By:    /s/ Kellie Seringer
       ----------------------------
Name:  Kellie Seringer
Title: General Partner

Shares of Common Stock: 28,036
Warrants: 7,009
Aggregate Purchase Price @$5.15 per Share and $0.125 per Warrant: $

Address for Notice:
Symmetry Capital Management LLC
One Montgomery Street
Suite 3300
San Francisco, CA 94104

Tax ID No. (if applicable) 68-0532191

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PURCHASER: SYMMETRY PARALLAX PARTNERS, L.P.


By:    /s/ Kellie Seringer
       ----------------------------
Name:  Kellie Seringer
Title: General Partner

Shares of Common Stock: 4,835
Warrants: 1,209
Aggregate Purchase Price @$5.15 per Share and $0.125 per Warrant: $

Address for Notice:
Symmetry Capital Management LLC
One Montgomery Street
Suite 3300
San Francisco, CA 94104

Tax ID No. (if applicable) 05-0575656

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PURCHASER: THE RIVERVIEW GROUP, LLC


By:    /s/ Terry Feeney
       ----------------------------
Name:  Terry Feeney
Title: Chief Operating Officer

Shares of Common Stock: 291,025
Warrants: 72,756
Aggregate Purchase Price @$5.15 per Share and $0.125 per Warrant: $1,507,873.28

Address for Notice:

666 Fifth Avenue, 8th Floor
New York, NY 10103

Tax ID No. (if applicable) 11-3485705

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PURCHASER: THE TAIL WIND FUND LTD.


By:    /s/ David Crook
       ----------------------------
Name:  David Crook, Esq.
Title: Chief Executive Officer

Shares of Common Stock: 96,502
Warrants: 24,125
Aggregate Purchase Price @$5.15 per Share and $0.125 per Warrant: $1,507,873.28

Address for Notice:
David Crook, Esq.
Chief Executive Officer
Tail Wind Advisory & Management Ltd.
1st Floor, No. 1 Regent Street
London, SW1Y 4NS UK

Tax ID No. (if applicable) N/A

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PURCHASER: TOPAZ PARTNERS


By:    /s/ Herbert J. Marks
       ----------------------------
Name:  Herbert J. Marks
Title: Managing Director

Shares of Common Stock: 482,509
Warrants: 120,627
Aggregate Purchase Price @$5.15 per Share and $0.125 per Warrant: $2,500,000

Address for Notice:

Jemmco Capital
900 Third Avenue
New York, NY 10022

Tax ID No. (if applicable) 13-3939025

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PURCHASER: TREELINE


By:    /s/ Joseph Gil
       ----------------------------
Name:  Joseph Gil
Title: CFO EFN

Shares of Common Stock: 96,502
Warrants: 24,125
Aggregate Purchase Price @$5.15 per Share and $0.125 per Warrant: $500,000.00

Address for Notice:

Tax ID No. (if applicable) ________________________

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PURCHASER: URSUS CAPITAL LP


By:    /s/ Evan Sturza
       ----------------------------
Name:  Evan Sturza
Title: General Partner

Shares of Common Stock: 56,900
Warrants: 14,225
Aggregate Purchase Price @$5.15 per Share and $0.125 per Warrant: $294,813.13

Address for Notice:

156 West 56th Street
16th Floor
New York, NY 10019

Tax ID No. (if applicable) 13-4011844

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PURCHASER: URSUS OFFSHORE LTD.


By:    /s/ Evan Sturza
       ----------------------------
Name:  Evan Sturza
Title: Managing Director

Shares of Common Stock: 39,602
Warrants: 9,900
Aggregate Purchase Price @$5.15 per Share and $0.125 per Warrant: $205,187.80

Address for Notice:

156 West 56th Street
16th Floor
New York, NY 10019

Tax ID No. (if applicable) N/A

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PURCHASER: VGE III PORTFOLIO LTD.


By:    /s/ Brian Smith
       ----------------------------
Name:  Brian Smith
Title: Chief Financial Officer

Shares of Common Stock: 419,900
Warrants: 104,975
Aggregate Purchase Price @$5.15 per Share and $0.125 per Warrant: $2,175,606.88

Address for Notice:
Viking Global Investors LP
55 Railroad Avenue
Greenwich, CT 06830-6378

Tax ID No. (if applicable) ________________________

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PURCHASER: VIKING GLOBAL EQUITIES LP


By:    /s/ Brian Smith
       ----------------------------
Name:  Brian Smith
Title: Chief Financial Officer

Shares of Common Stock: 430,100
Warrants: 107,525
Aggregate Purchase Price @$5.15 per Share and $0.125 per Warrant: $2,228,455.63

Address for Notice:
Viking Global Investors LP
55 Railroad Avenue
Greenwich, CT 06830-6378

Tax ID No. (if applicable) _______________________

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PURCHASER: WESTFORD GLOBAL ASSET MANAGEMENT LTD-GP


By:    /s/ Steve Stevanovich
       ----------------------------
Name:  Steve Stevanovich
Title: President

Shares of Common Stock: 25,000
Warrants: 6,250
Aggregate Purchase Price @$5.15 per Share and $0.125 per Warrant: $129,531.25

Address for Notice:
7280 W. Palmetto Park Road
Suite 310
Boca Raton, FL 33433

Tax ID No. (if applicable) N/A Foreign

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