# Patent

## Title
Para-terphenyl compounds

## Abstract

The present invention provides a selective suppressor of the IgE production comprising a compound which suppresses the IgE production in a process from a differentiation of a mature B cell into an antibody-producing cell to the production of an antibody and which does not suppress or weakly suppresses the production of IgG, IgM and/or IgA which are produced at the same time, a compound of the formula (I):




wherein R1–R13 are hydrogen, halogen, lower alkyl, lower alkoxy or the like, X is —O—, —CH2—, NR14— or —S(O)p— and Y is lower alkyl, lower alkenyl or the like, a process for producing the same and a pharmaceutical composition comprising the same.

## Background
This application is a Divisional of co-pending application Ser. No. 09/214,277 filed on Mar. 1, 1999 and for which priority is claimed under 35 U.S.C. § 120 application Ser. No. 09/214,277 is the national phase of PCT International Application No. PCT/JP97/02635 filed on Jul. 30, 1997 under 35 U.S.C. § 371. The entire contents of each of the above-identified applications are hereby incorporated by reference. This application also claims priority of Application No. 8-201859, 8-287782 and 9-86085 filed in Japan on Jul. 31, 1996, Oct. 30, 1996 and Mar. 18, 1997, respectively under 35 U.S.C. § 119.


TECHNICAL FIELD
The present invention relates to a novel para-terphenyl compound, a process for producing the same, a selective suppressor of the IgE production, an immunosuppressor and an anti-allergic agent.
BACKGROUND ART
A serious problem of a transplantation of a tissue or an organ which is frequently performed in recent years is a rejection symptom for excluding a transplanted part after an operation. Prevention of the rejection symptom is very important for a success of the transplantation.
Various immunosuppressors such as azathioprine, corticoid, Cyclosporin A, Tacrolimus and the like are developed and come into practical use for prevention and a treatment of a rejection symptom against a transplantation of an organ or a tissue or a graft-versus-host reaction which is caused by a bone marrow transplantation. But they are not so satisfactory in view of their effects and side effects.
Allergic diseases such as atopic dermatitis, allergic rhinitis, bronchial asthma, allergic conjunctivitis and the like globally tend to increase in recent years and become serious problems. The conventional antiinflammatory agents are suppressors of releasing chemical mediators from mast cells, receptor inhibitors of the chemical mediators released, suppressors of allergic inflammation reaction or the like. All of these are agents for symptomatic therapy and are not fundamental therapeutic agents for allergic diseases.
As an fundamental therapeutic agent for allergic diseases, a suppressor of the IgE antibody production has been expected.
One of compounds which have a suppressive effect on the IgE production is Suplatast Tosilate (IPD-1151-T). This is reported to act on T cell of type 2 (Th2 cell) to suppress the IL-4 production and to suppress a differentiation of B cells to IgE antibody-producing cells (Jpn. Pharmacol. (1993) 61, 31–39).
As compounds which directly act on B cells to suppress the IgE antibody production, for example, DSCG (Intal) or Nedcromil sodium which are degranulation inhibitors of mast cells are exemplified. These are reported to inhibit a class-switch of B cells (J. Exp. Med. (1994)180: 663–671, J. Allergy Clin. Immunol.(1996) 97: 1141–1150). In J. Med. Chem. (1997) 40: 395–407, a compound which directly acts on B cells to suppress the IgE production is described.
Because immune globulins are necessary for phylaxis and a suppression of immune globulins other than IgE antibody is not preferable, an inhibitor which has a high selectivity to IgE and a potent effect has been desired.
The compounds which have an antiinflammatory effect and ortho-terphenyl structure are described in JP-A 60-13730, J. Med. Chem.(1996) 39: 1846–1856 and WO96/10012, and the compounds which have the same effect and biphenyl structure are described in JP-B 43-19935, JP-A 62-294650 and WO96/18606.
The compounds which have para-terphenyl structure are described in Chemical & Pharmaceutical Bulletin, 24 (4), 613–620 (1976), The Journal of Antibiotics, 32 (6), 559–564 (1979) and Agricultural Biological Chemistry, 49 (3), 867–868 (1985) but an immunosuppressive or antiinflammatory effect of these compounds is not described at all.
DISCLOSURE OF INVENTION
An object of the present invention is to provide a selective suppressor of the IgE production, an immunosuppressor, and/or an anti-allergic agent which has a potent suppressive effect on the IgE production, an immunosuppressive effect and/or an antiallergic effect. Other object of the present invention is to provide novel compounds which have the above effects and a process for producing the same.
The present invention provides a selective suppressor of the IgE production, an immunosuppressor and/or an anti-allergic agent comprising a compound which suppresses the IgE production in a process from a differentiation of a mature B cell into an antibody-producing cell to the production of an antibody and which does not suppress or weakly suppresses the production of IgG, IgM and/or IgA which are produced at the same time. The present invention provides a method for selectively suppressing the IgE production or for suppressing an immune reaction or a method for treating and/or preventing allergic diseases comprising administering the compound. In another embodiment, the present invention provides use of the compound for the manufacture of a medicament for selectively suppressing the IgE production, suppressing the immune reaction or treating and/or preventing allergic diseases.
The present invention provides a compound of the formula (I) as an example of the compounds which has the above effects:




wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12 and R13 are each independently hydrogen, hydroxy, halogen, carboxy, optionally substituted lower alkyl, optionally substituted lower alkoxy, optionally substituted lower alkenyl, optionally substituted lower alkenyloxy, optionally substituted lower alkylthio, optionally substituted lower alkoxycarbonyl, optionally substituted acyloxy, optionally substituted lower alkylsulfonyl, optionally substituted lower alkylsulfonyloxy, optionally substituted lower alkylsulfinyl, nitro, cyano, formyl, optionally substituted amino, optionally substituted carbamoyl, optionally substituted sulfamoyl or optionally substituted heterocyclyl,

    X is —O—, —CH2—, —NR14— wherein R14 is hydrogen, optionally substituted lower alkyl, optionally substituted lower alkenyl or acetyl, or —S(O)p— wherein p is an integer of 0 to 2,
    Y is optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl, optionally substituted acyl, optionally substituted cycloalkyl, optionally substituted cycloalkenyl, optionally substituted aryl or optionally substituted heterocyclyl, and Y may optionally be substituted lower alkoxy when X is —CH2— and may optionally be substituted lower alkoxycarbonyl, optionally substituted lower alkylsulfonyl or optionally substituted arylsulfonyl when X is —O— or —NR14—,
    R1 and R4, R1 and R2, R2 and R3, R4 and R5, R6 and R7, R8 and R9, R10 and R11, R12 and R13, R11 and —X—Y, or R13 and —X—Y taken together may form a 5- or 6-membered ring which may contain one or more of O, S or NR15 wherein R15 is hydrogen, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted arylsulfonyl and which may optionally be substituted, excluding compounds wherein one or more of R6, R7, R8 and R9 are halogen and the others are hydrogen, all of R6, R7, R8 and R9 are halogen and all of R2–R13 are hydrogen, halogen or cyano,
    provided that R1 is not hydrogen, fluorine, optionally substituted lower alkyl or optionally substituted lower alkoxy, all of R2, R3, R4, R5 and R12 are hydrogen, or R13 is not hydrogen or halogen when R6, R7, R8 and R9 are all simultaneously hydrogen, and further provided that R1 is not methyl or acetyloxy, R13 is not hydrogen, optionally substituted lower alkoxycarbonyl or optionally substituted carbamoyl, or —X—Y is not methoxy when at least one of R6, R7, R8 and R9 is a substituent other than hydrogen, and excluding a compound of the formula (I′):






wherein R1 is hydrogen or hydroxy and R13′ is hydroxy or methoxy, pharmaceutically acceptable salt, hydrate or prodrug thereof.

The present invention provides a pharmaceutical composition, more specifically a selective suppressor of the IgE production, an immunosuppressor or an anti-allergic agent, comprising the compound (1), pharmaceutically acceptable salt, hydrate or prodrug thereof.
The present invention provides a selective suppressor of the IgE production, an immunosuppressor and/or an anti-allergic agent comprising a compound of the formula




wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12 and R13 are each independently hydrogen, hydroxy, halogen, carboxy, optionally substituted lower alkyl, optionally substituted lower alkoxy, optionally substituted lower alkenyl, optionally substituted lower alkenyloxy, optionally substituted lower alkylthio, optionally substituted lower alkoxycarbonyl, optionally substituted acyloxy, optionally substituted lower alkylsulfonyl, optionally substituted lower alkylsulfonyloxy, optionally substituted lower alkylsulfinyl, nitro, cyano, formyl, optionally substituted amino, optionally substituted carbamoyl, optionally substituted sulfamoyl or optionally substituted heterocyclyl,

    X is —O—, —CH2—, —NR14— wherein R14 is hydrogen, optionally substituted lower alkyl, optionally substituted lower alkenyl or acetyl, or —S(O)p— wherein p is an integer of 0 to 2, Y is optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl, optionally substituted acyl, optionally substituted cycloalkyl, optionally substituted cycloalkenyl, optionally substituted aryl or optionally substituted heterocyclyl, and Y may optionally be substituted lower alkoxy when X is —CH2— and may optionally be substituted lower alkoxycarbonyl, optionally substituted lower alkylsulfonyl or optionally substituted arylsulfonyl when X is —O— or —NR14—, R1 and R4, R1 and R2, R2 and R3, R4 and R5, R6 and R7, R8 and R9, R10 and R11, R12 and R13, R11 and —X—Y, or R13 and —X—Y taken together may form a 5- or 6-membered ring which may contain one or more of O, S or NR15 wherein R15 is hydrogen, optionally substituted lower alkyl, optionally substituted lower alkenyl or optionally substituted arylsulfonyl and which may optionally be substituted, excluding a compound of the formula (I′):






wherein R1′ is hydrogen or hydroxy and R13′ is hydroxy or methoxy, pharmaceutically acceptable salt, hydrate or prodrug thereof. The present invention provides a method for selectively suppressing the IgE production, suppressing an immune reaction or treating or preventing allergic diseases comprising administering the compound (I) or (I′). In another embodiment, the present invention provides use of the compound (I) or (I′) for manufacturing of a medicament for selectively suppressing the IgE production, suppressing the immune reaction or treating or preventing allergic diseases.

In one of the other embodiments, the present invention provides a process for producing a compound of the formula (I′′′):




the compound of the above formula (I) or (I′), pharmaceutically acceptable salt or hydrate thereof

wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12 and R13 are each independently hydrogen, hydroxy, halogen, carboxy, optionally substituted lower alkyl, optionally substituted lower alkoxy, optionally substituted lower alkenyl, optionally substituted lower alkenyloxy, optionally substituted lower alkylthio, optionally substituted lower alkoxycarbonyl, optionally substituted acyloxy, optionally substituted lower alkylsulfonyl, optionally substituted lower alkylsulfonyloxy, optionally substituted lower alkylsulfinyl, nitro, cyano, formyl, optionally substituted amino, optionally substituted carbamoyl, optionally substituted sulfamoyl or optionally substituted heterocyclyl,

    X is —O—, —CH2—, —NR14— wherein R14 is hydrogen, optionally substituted lower alkyl, optionally substituted lower alkenyl or acetyl, or —S(O)p— wherein p is an integer of 0 to 2,
    Y is optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl, optionally substituted acyl, optionally substituted cycloalkyl, optionally substituted cycloalkenyl, optionally substituted aryl or optionally substituted heterocyclyl, and Y may optionally be substituted lower alkoxy when X is —CH2— and may optionally be substituted lower alkoxycarbonyl, optionally substituted lower alkylsulfonyl or optionally substituted arylsulfonyl when X is —O— or —NR14—,
    R1 and R4, R1 and R2, R2 and R3, R4 and R5, R6 and R7, R8 and R9, R10 and R11, R12 and R13, R11 and —X—Y, or R13 and —X—Y taken together may form a 5- or 6-membered ring which may contain one or more of O, S or NR15 wherein R15 is hydrogen, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted arylsulfonyl, and which may optionally be substituted,
    excluding a compound wherein one or more of R6, R7, R8 and R9 are halogen and the others are hydrogen, all of R6, R7, R8 and R9 are halogen and all of R2–R13 are hydrogen, halogen or cyano,
    provided that R1 is not hydrogen, fluorine; optionally substituted lower alkyl or optionally substituted lower alkoxy, all of R2, R3, R4, R5 and R12 are hydrogen or R13 is not hydrogen or halogen when R6, R7, R8 and R9 are all simultaneously hydrogen, and further provided that R1 is not methyl or acetyloxy, R13 is not hydrogen, optionally substituted lower alkoxycarbonyl or optionally substituted carbamoyl or —X—Y is not methoxy when at least one of R6, R7, R8 and R9 is a substituent other than hydrogen, pharmaceutically acceptable salt or hydrate thereof, which comprises reacting a compound of the formula (II):






with a compound of the formula (III):





wherein, in the formulas (II) and (III), R1–R13, X and Y are the same as defined in the above formula (I), either of A and Z is dihydroxyborane, di(lower)alkoxyborane, di(lower)alkylborane,





and the other is halogen or —OSO2(CqF2q+1)— wherein q is an integer of 0 to 4, or reacting a compound of the formula (II′):





with a compound of the formula (III′):





wherein, in the formulas (II′) and (III′), R1–R13, X and Y are the same as defined in the above formula (I) and A and Z are the same as defined in the above formulas (II) and (III). As another process, the present invention provides a process for producing the compound of the above formula (I′′′), (I) or (I′), pharmaceutically acceptable salt or hydrate thereof comprising the reaction of a compound of the formula (IV):





with a compound of the formula (V):





wherein, in the formulas (IV) and (V), R1–R9 are the same as defined in the above formula (I), Z1 is the same as Z defined in the above formula (II), A1 and A2 are each independently the same as A defined in the above formula (III) and the reactivity of A1 is higher than or equal to that of A2,

    followed by the reaction with a compound of the formula (VI):






wherein R10–R13, X and Y are the same as defined in the above formula (1) and Z2 is the same as Z defined in the above formula (II) and a process for producing the compound of the above formula (I′′′), (I) or (I′), pharmaceutically acceptable salt, hydrate thereof comprising the reaction of a compound of the formula (IV′):





wherein R6–R9 is the same as defined in the above formula (I), A1 and A2 are each independently the same as A defined in the above formula (III) and the reactivity of A2 is higher than or equal to that of A1,

    with a compound of the above formula (VI), followed by the reaction with a compound of the above formula (V).





BRIEF DESCRIPTION OF THE DRAWINGS
FIG. 1 shows an antibody production-suppressive effect on human peripheral lymphocytes of the compound (I-839) of the present invention. The ordinate represents a percentage of the amount of antibodies to that of antibodies which are produced in the absence of the compound. The abscissa represents a concentration of the compound.
FIG. 2 shows an antibody production-suppressive effect on human peripheral lymphocytes of the compound No. 36. The ordinate represents a percentage of the amount of antibodies to that of antibodies which are produced in the absence of the compound. The abscissa represents a concentration of the compound.
FIG. 3 shows an antibody production-suppressive effect on mouse spleen lymphocytes of the compound (I-967) of the present invention. The ordinate represents a percentage of the amount of antibodies to that of antibodies which are produced in the absence of the compound. The abscissa represents a concentration of the compound.
FIG. 4 shows a suppressive effect of the compound (I-963) of the present invention for an infiltration of inflammatory cells to irrigation water of pulmonary alveolus by an antigen stimulation on mice. The ordinate represents the number of inflammatory cells and the abscissa represents the number of total inflammatory cells, the number of macrophages, the number of eosinophils and the number of neutrophils. The white column represents a group inhaling saline instead of ovalbumin, the black column represents a group inhaling an antigen to cause inflammation and without administration of any compound of the present invention, and the gray column represents a group inhaling an antigen to cause inflammation with administration of the compound of the present invention.



BEST MODE FOR CARRYING OUT THE INVENTION
In the present specification, the term “halogen” includes fluorine, chlorine, bromine and iodine. Fluorine or chlorine is preferable. The halogen in the term “halogeno(lower)alkyl”, “halogeno(lower)alkenyl” and “halogenoaryl” is the same as above.
The term “lower alkyl” represents straight or branched chain alkyl having 1 to 10 carbon atoms, preferably 1 to 8 carbon atoms, more preferably 1 to 6 carbon atoms and most preferably 1 to 4 carbon atoms. For example, included are methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, n-pentyl, isopentyl, neopentyl, hexyl, isohexyl, n-heptyl, isoheptyl, n-octyl, isooctyl, n-nonyl, n-decyl and the like.
As substituents of the “optionally substituted lower alkyl” in R1–R13, R14 and R15 exemplified are halogen; hydroxy; lower alkoxy optionally substituted with lower alkoxy; carboxy; lower alkoxycarbonyl; acyloxy and the like and the lower alkyl may be substituted with one or more of these substituents at any possible positions.
As substituents for “optionally substituted lower alkyl” in Y exemplified are halogen; hydroxy; carboxy; lower alkoxycarbonyl; lower alkoxy optionally substituted with lower alkoxy; acyl; acyloxy; amino optionally substituted with hydroxy or lower alkyl; imino optionally substituted with hydroxy, lower alkoxy, carboxy(lower)alkoxy, aryl(lower)alkoxy or heterocyclyl; hydrazono optionally substituted with carbamoyl or lower alkoxycarbonyl; cycloalkyl optionally substituted with lower alkyl; cycloalkenyl optionally substituted with lower alkyl; cyano; carbamoyl optionally substituted with lower alkyl or amino; thiocarbamoyl optionally substituted with lower alkyl;




wherein ring A represents cycloalkyl or heterocyclyl; aryl optionally substituted with lower alkyl, halogeno(lower)alkyl, carboxy(lower)alkyl, lower alkoxycarbonyl(lower)alkyl, halogen, hydroxy, lower alkoxy, carboxy, lower alkoxycarbonyl, lower alkenyloxycarbonyl, acyloxy, nitro, cyano, amino, lower alkoxycarbonylamino, acylamino, lower alkylsulfonylamino, lower alkylamino or guanidino; or

    heterocyclyl optionally substituted with lower alkyl (optionally substituted with heterocyclyl), halogen, hydroxy, carboxy, lower alkoxycarbonyl, lower alkylsulfonyl, lower alkylarylsulfonyl, mercapto, lower alkylthio or heterocyclyl optionally substituted with aryl.


The alkyl part of “halogeno(lower)alkyl”, “hydroxy(lower)alkyl”, “carboxy(lower)alkyl”, “lower alkoxycarbonyl(lower)alkyl”, “lower alkylthio”, “lower alkylamino”, “lower alkylsulfonyl”, “lower alkylsulfonyloxy”, “lower alkylsulfonylamino”, “lower alkylsulfinyl”, “lower alkylaryl”, “lower alkylarylsulfonyl”, “di(lower)alkylcarbamoyl”, “di(lower)alkylborane, “lower alkoxy”, “carboxy(lower)alkoxy”, “aryl(lower)alkoxy”, “lower alkoxy(lower)alkoxy”, “lower alkoxyaryl” or “di(lower)alkoxyborane” is the same as defined in the above “lower alkyl”. As substituents in the case of being “optionally substituted” exemplified are halogen; hydroxy; lower alkoxy; carboxy; lower alkoxycarbonyl; acyloxy; cycloalkyl; aryl optionally substituted with lower alkyl; heterocyclyl and the like. These substituents may substitute at one or more of any possible positions.
The part of lower alkyl in “lower alkoxycarbonyl” is the same as the above defined “lower alkyl” and substituents for “optionally substituted lower alkoxycarbonyl” are the same as those for the above “optionally substituted lower alkoxy”.
The part of “lower alkoxycarbonyl” in “lower alkoxycarbonyl(lower)alkyl”, “lower alkoxycarbonyl(lower)alkenyl” or “lower alkoxycarbonylamino” is the same as the above defined “lower alkoxycarbonyl”.
The term “lower alkenyl” represents straight or branched chain alkenyl having 2 to 10 carbon atoms, preferably 2 to 8 carbon atoms and more preferably 3 to 6 carbon atoms. For example, included are vinyl, propenyl, isopropenyl, butenyl, isobutenyl, butadienyl, pentenyl, isopentenyl, pentadienyl, hexenyl, isohexenyl, hexadienyl, heptenyl, octenyl, nonenyl, decenyl and the like and these have one or more double bonds at any possible positions. Substituents for “optionally substituted lower alkenyl” are the same as that for the above “optionally substituted lower alkoxy”.
The part of lower alkenyl in “lower alkoxycarbonyl(lower)alkenyl”, “halogeno(lower)alkenyl”, “lower alkenyloxy”, “lower alkenyloxycarbonyl” or “lower alkenylamino” is the same as the above defined “lower alkenyl”.
Substituents for “optionally substituted lower alkenyloxy” are the same as those for the above “optionally substituted lower alkoxy”.
The term “lower alkynyl” represents straight or branched chain alkynyl having 2 to 10 carbon atoms, preferably 2 to 8 carbon atoms and more preferably 3 to 8 carbon atoms. Specifically, included are ethynyl, propynyl, butynyl; pentynyl, hexynyl, heptynyl, octynyl, nonyl, decynyl and the like. These have one or more triple bonds at any possible positions and may further have a double bond. Substituents for “optionally substituted lower alkynyl” are the same as those for the above “optionally substituted lower alkoxy”.
The term “acyl” represents aliphatic acyl which includes chain acyl having 1 to 10 carbon atoms, preferably 1 to 8 carbon atoms, more preferably 1 to 6 carbon atoms, most preferably 1 to 4 carbon atoms and cyclic acyl having 3 to 8 carbon atoms, preferably 3 to 6 carbon atoms, and aroyl. Specifically, included are formyl, acetyl, propionyl, butyryl, isobutyryl, valeryl, pivaloyl, hexanoyl, acryloyl, propioloyl, methacryloyl, crotonoyl, cyclohexanecarbonyl, benzoyl and the like. Substituents for “optionally substituted acyl” are the same as those for “optionally substituted lower alkoxy” and aroyl may further be substituted with lower alkyl.
The part of acyl in “acyloxy” or “acylamino” is the same as the above identified “acyl” and substituents for “optionally substituted acyloxy” are the same as those for the above “optionally substituted acyl”.
The term “cycloalkyl” represent cyclic hydrocarbon having 3 to 6 carbon atoms and includes, for example, cyclopropyl, cyclobutyl, cyclopentyl cyclohexyl and the like. As substituents for “optionally substituted cycloalkyl” exemplified are lower alkyl, halogen, hydroxy, carboxy, lower alkoxycarbonyl, lower alkoxy, aryl, heterocyclyl and the like and the cycloalkyl may be substituted at any possible positions.
The term “cycloalkenyl” represents the group having one or more double bonds at any possible positions in the above cycloalkyl and included are, for example, cyclopropenyl, cyclobutenyl, cyclopentenyl, cyclohexenyl, cyclohexadienyl and the like. Substituents for “optionally substituted cycloalkenyl” are the same as those for the above identified “cycloalkyl”.
The term “optionally substituted amino” includes substituted amino and unsubstituted amino and substituents exemplified are lower alkyl optionally substituted with lower alkylaryl etc.; lower alkenyl optionally substituted with halogen; lower alkylsulfonyl; lower alkylarylsulfonyl; lower alkoxycarbonyl; sulfamoyl; acyl optionally substituted with halogen; carbamoyl and the like.
The term “optionally substituted carbamoyl” includes substituted carbamoyl and unsubstituted carbamoyl and substituents exemplified are lower alkyl; lower alkylsulfonyl; sulfamoyl; acyl optionally substituted with halogen; amino and the like.
The term “optionally substituted sulfamoyl” includes substituted sulfamoyl and unsubstituted sulfamoyl and substituents exemplified are lower alkyl optionally substituted with aryl; lower alkenyl and the like.
The term “aryl” includes phenyl, naphthyl, anthryl, indenyl, phenanthryl and the like. Substituents for “optionally substituted aryl” exemplified are lower alkyl optionally substituted with halogen or carboxy; hydroxy; halogen; lower alkoxy; lower acyloxy; carboxy; lower alkoxycarbonyl; lower alkenyloxycarbonyl; amino optionally substituted with lower alkyl, lower alkylsulfonyl, lower alkoxycarbonyl or acyl; guanidino; nitro; aryl; heterocyclyl and the like and “optionally substituted aryl” may be substituted with one or more of these substituents at any possible positions.
The part of aryl in “lower alkylaryl”, “halogenoaryl”, “lower alkoxyaryl”, “arylsulfonyl”, “aryl(lower)alkoxy”, “lower alkylarylsulfonyl”, “heterocyclyl substituted with aryl”, “aroyl” or “aroyloxy” is the same as the above “aryl” and the substituents for “optionally substituted” are also the same as those for in the above “optionally substituted aryl”.
The term “heterocyclyl” represents a heterocyclic group which contains one or more of hetero atoms arbitrarily selected from a group of O, S and N and exemplified are 5- or 6-membered aromatic heterocyclyl such as pyrrolyl, imidazolyl, pyrazolyl, pyridyl, pyridazinyl, pyrimidinyl, pyrazinyl, triazolyl, triazinyl, isoxazolyl, oxazolyl, oxadiazolyl, isothiazolyl, thiazolyl, thiaziazolyl, furyl, thienyl etc., condensed aromatic heterocyclyl such as indolyl, carbazolyl, acridinyl, benzimidazolyl, indazolyl, indolizinyl, quinolyl, isoquinolyl, cinnolinyl, phthalazinyl, quinazolinyl, naphthyridinyl, quinoxalinyl, purinyl, pteridinyl, benzisoxazolyl, benzoxazolyl, benzoxadiazolyl, benzisothiazolyl, benzothiazolyl, benzothiaziazolyl, benzofuryl, benzothienyl, benzotriazolyl etc., and alicyclic heterocyclyl such as dioxanyl, thiiranyl, oxiranyl, oxathioranyl, azetidinyl, thianyl, pyrrolidinyl, pyrrolinyl, imidazolidinyl, imidazolinyl, pyrazolidinyl, pyrazolinyl, piperidyl, piperazinyl, morpholinyl etc. As substituents for “optionally substituted heterocyclyl” exemplified are lower alkyl, lower alkenyl, hydroxy, halogen, carboxy, lower alkoxycarbonyl, lower alkoxy, mercapto, lower alkylthio, lower alkylsulfonyl, aryl; heterocyclyl and the like and the heterocyclyl may be substituted with one or more of these substituents at any possible positions. The part of heterocycle in “heterocyclyl substituted with aryl” is the same as the above “heterocyclyl”.
The term “5- or 6-membered ring which may contain one or more of O, S or NR15 and may optionally be substituted” represents a 5- or 6-membered ring which is formed by R1 and R4, R1 and R2, R2 and R3, R4 and R5, R6 and R7, R8 and R9, R10 and R11, R12 and R13, R11 and —X—Y, or R13 and —X—Y with the two carbon atoms constituting phenyl to which the above substituents are attached. For example, the above substituents taken together form —(CH2)3—, —(CH2)4—, —O(CH2)mO—, —O(CH2)n—, —(CH2)n—, —S(CH2)mS—, S(CH2)n—, —(CH2)nS—, —NR15(CH2)mNR15, —NR15(CH2)n—, (CH2)nNR15, —O(CH2)mS—, —S(CH2)mO—, —S(CH2)mNR15, —NR15(CH2)mS—, —O(CH2)mNR15—, —NR15(CH2)mO—, —O—CH═CH—, —CH═CH—O—, —S—CH═CH—, —CH═CH—S—, —NR15—CH═CH—, —CH═CH—NR15—, —S—CH═N—, —N═CH—S—, —S—N═CH—, —CH═N—S—, —O—CH═N—, —N═CH—O—, —O—N═CH—, —CH═N—O—, —NR15—CH═N—, —N═CH—NR15—, —NR15—N═CH—, —CH═N—NR15—, —N═CH—CH═CH—, —CH═CH—CH═N—, —N═N—CH═CH—, —CH═CH—N═N—, —N═CH—N═CH—, —CH═N—CH═N—, —N═CH—CH═N— (m is 1 or 2 and n is 2 or 3) or the like and further these and the two carbon atoms constituting phenyl taken together form a 5- or 6-membered ring. These rings may be substituted with one or more of hydroxy; halogen; lower alkyl optionally substituted with lower alkoxycarbonyl or heterocyclyl; lower alkenyl optionally substituted with halogen; lower alkyliden optionally substituted with halogen; or the like. The substituents of “5- or 6-membered ring which may contain one or more of O or NR15 and may optionally be substituted”, “5- or 6-membered ring which contains one or more of O or NR15 and may optionally be substituted” and “5 or 6-membered ring which contains one or more of 0 and may optionally be substituted” are the same as the above unless otherwise defined.
The term “lower alkylidene” represents straight or branched alkylidene having 1 to 6 carbon atoms, preferably 1 to 4 carbon atoms, more preferably 1 to 3 carbon atoms and includes, for example, methylene, ethylidene, isopropylidene, vinylidene, methylidyne and the like.
The term “all of R2–R13 are hydrogen, halogen or cyano” represents, for example, the case that R2–R13 are the same or different and hydrogen, halogen or cyano. For example, included are the case that all of R2–R13 are hydrogen, the case that all of them are halogen, the case that some are halogen and the others are hydrogen, the case that some are cyano and the others are hydrogen, the case that some are halogen, some are cyano and the others are hydrogen and the like.
The term “compound (I)”, “compound (I′′)” or “compound (I′′′)” also includes formable and pharmaceutically acceptable salts of each compounds. As “the pharmaceutically acceptable salt”, exemplified are salts with mineral acid such as hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, hydrofluoric acid, hydrobromic acid and the like; salts with organic acids such as formic acid, acetic acid, tartaric acid, lactic acid, citric acid, fumaric acid, maleic acid, succinic acid and the like; salts with organic bases such as ammonium, trimethylammonium, triethylammonium and the like; salts with alkaline metals such as sodium, potassium and the like and salts with alkaline earth metals such as calcium, magnesium and the like.
The compound of the present invention includes hydrates and all of stereoisomers, for example, atropisomers etc. thereof.
The compound of the present invention includes prodrugs thereof. The term “prodrug” means a group of compounds which are easily changeable to the compounds (I) or (I′′) which have activities in living bodies. The prodrug may be prepared by usual reactions. As usual methods for producing prodrugs exemplified is the substitution of hydroxy by acyloxy substituted with carboxy, sulfo, amino, lower alkylamino or the like, phosphonoxy or the like. The substitution of hydroxy attached to R1 by —OCOCH2CH2COOH, —OCOCH═CHCOOH, —OCOCH2SO3H, —OPO3H2, —OCOCH2NMe2, —OCO—Pyr (Pyr is pyridine) or the like is preferable.
In the present specification, the term “compound (I)” represents a group comprising novel compounds excluding the compound (I′), the term “compound (I′′)” represents a group comprising the compound (I) and known compounds and the term “compound (I′′′)” represents a group comprising the compound (I) and the compound (I′).
All of the compounds (I) and (I′′) have a suppressive effect on the IgE production, an immunosuppressive effect and/or an anti-allergic effect and the following compounds are specifically preferable.
In the formulas (I) and (I′′),

    1) a compound wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12 and R13 are each independently hydrogen, hydroxy, halogen, carboxy, optionally substituted lower alkyl, optionally substituted lower alkoxy, optionally substituted lower alkenyl, optionally substituted lower alkenyloxy, optionally substituted lower alkylthio, optionally substituted lower alkoxycarbonyl, optionally substituted acyloxy, optionally substituted lower alkylsulfonyloxy, formyl, optionally substituted amino, optionally substituted carbamoyl or optionally substituted sulfamoyl,
    X is —O—, —CH2—, —NR14— wherein R14 is hydrogen or optionally substituted lower alkyl, or —S(O)p— wherein p is an integer of 0 to 2,
    Y is optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl, optionally substituted acyl or optionally substituted cycloalkenyl, and
    R1 and R4, R1 and R2, R8 and R9, R11 and —X—Y, or R13 and —X—Y taken together may form a 5- or 6-membered ring which may contain one or more of O or NR15,
    2) a compound wherein R1 is hydrogen, hydroxy, halogen, carboxy, optionally substituted lower alkyl, optionally substituted lower alkoxy, optionally substituted lower alkenyloxy, optionally substituted lower alkylthio, optionally substituted lower alkoxycarbonyl, optionally substituted lower alkylsulfonyloxy, lower alkylsulfonyl, formyl, optionally substituted amino, lower alkylsulfinyl, acyloxy, nitro, cyano, optionally substituted sulfamoyl or heterocyclyl,
    R2 is hydrogen, hydroxy, halogen, optionally substituted lower alkyl or optionally substituted lower alkylsulfonyloxy,
    R3 is hydrogen, hydroxy, halogen or optionally substituted lower alkoxy,
    R4 is hydrogen, optionally substituted lower alkyl, halogen, optionally substituted lower alkoxy, nitro or optionally substituted amino,
    R5 is hydrogen, optionally substituted lower alkoxy, lower alkoxycarbonyl or carboxy,
    R6 is hydrogen, halogen, optionally substituted lower alkyl, carboxy, lower alkoxycarbonyl, nitro, formyl, amino or lower alkylsulfonyloxy,
    R7 and R8 are each independently hydrogen, halogen, optionally substituted lower alkyl, optionally substituted lower alkoxy, formyl or optionally substituted amino,
    R9 is hydrogen, hydroxy, carboxy, optionally substituted lower alkyl, optionally substituted lower alkoxy, optionally substituted lower alkenyl, optionally substituted lower alkoxycarbonyl, optionally substituted lower alkylsulfonyloxy, formyl, optionally substituted carbamoyl or optionally substituted amino,
    R10 is hydrogen or lower alkoxy,
    R11 is hydrogen, halogen, optionally substituted lower alkyl, carboxy, lower alkoxycarbonyl, optionally substituted lower alkylsulfonyloxy, formyl, nitro or amino,
    R12 is hydrogen,
    R13 is hydroxy, halogen, carboxy, optionally substituted lower alkyl, optionally substituted lower alkoxy, optionally substituted lower alkenyloxy, optionally substituted acyloxy, optionally substituted lower alkylsulfonyloxy, formyl, nitro or optionally substituted amino, and further R13 may be hydrogen in the formula (I”),
    Y is optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl, optionally substituted acyl or optionally substituted cycloalkenyl and Y may be optionally substituted lower alkoxycarbonyl, optionally substituted lower alkylsulfonyl or optionally substituted arylsulfonyl when X is —O— or NR14—, and
    R1 and R2, R1 and R4, R8 and R9, R11 and —X—Y, or R13 and —X—Y taken together may form a 5- or 6-membered ring which contains one or more of O or NR15 wherein R15 is the same as defined above and which may optionally be substituted,
    3) a compound wherein R1 is hydrogen, hydroxy, halogen, carboxy, optionally substituted lower alkyl, optionally substituted lower alkoxy, optionally substituted lower alkenyloxy, optionally substituted lower alkylthio, optionally substituted lower alkoxycarbonyl, optionally substituted lower alkylsulfonyloxy, lower alkylsulfonyl, formyl, optionally substituted amino, lower alkylsulfinyl, acyloxy, nitro, cyano, optionally substituted sulfamoyl or heterocyclyl (hereinafter referred to as “R1 is R1-1”) or R1 and R2 or R4 taken together form a 5- or 6-membered ring which contains one or more of O or NR15 wherein R15 is the same as defined above and which may optionally be substituted,
    preferably R1 is hydrogen, hydroxy, halogen, optionally substituted lower alkoxy, optionally substituted lower alkenyloxy, optionally substituted lower alkylsulfonyloxy, optionally substituted amino, optionally substituted sulfamoyl (hereinafter referred to as “R1 is R1-2”), or R1 and R2 or R4 taken together form a 5- or 6-membered ring which contains one or more of O or NR15 wherein R15 is the same as defined above and which may optionally be substituted,
    more preferably, R1 is hydrogen, hydroxy, halogen, lower alkoxy(lower)alkoxy, aryl(lower)alkoxy, lower alkenyloxy, lower alkylsulfonyloxy, amino, lower alkylamino or lower alkenylamino (hereinafter referred to as “R1 is R1-3”), or R1 and R2 or R4 taken together form a 5- or 6-membered ring which contains one or more of O or NR15 wherein R15 is the same as defined above and which may optionally be substituted, most preferably, R1 is hydrogen, hydroxy, chlorine, fluorine, methoxymethyloxy, benzyloxy, 3-methyl-2-butenyloxy, methanesulfonyloxy, amino, dimethylamino or 3-methyl-2-butenylamino (hereinafter referred to as “R1 is R1-4”), or R1 and R2 or R4 taken together form —OCH2O— or —CH═CH—NH—,
    4) a compound wherein R2 is hydrogen, hydroxy, halogen, lower alkyl or optionally substituted lower alkylsulfonyloxy (hereinafter referred to as “R2 is R2-1”) or R1 and R2 taken together form a 5- or 6-membered ring which contains one or more of O or NR15 wherein R15 is the same as defined above and which may optionally be substituted, preferably R2 is hydrogen, halogen or alkyl having 1 to 3 carbon atoms (hereinafter referred to as “R2 is R2-2”),
    5) a compound wherein R3 is hydrogen, hydroxy, halogen or optionally substituted lower alkoxy (hereinafter referred to as “R3 is R3-1”), preferably R3 is hydrogen or halogen (hereinafter referred to as “R3 is R3-2”), more preferably R3 is hydrogen or fluorine (hereinafter referred to as “R3 is R3-3”),
    6) a compound wherein R4 is hydrogen, optionally substituted lower alkyl, halogen, optionally substituted lower alkoxy, nitro or optionally substituted amino (hereinafter referred to as “R4 is R4-1”) or R4 and R1 taken together may form a 5- or 6-membered ring which contains one or more of Q or NR15 wherein R15 is the same as defined above and which may optionally be substituted,
    preferably R4 is hydrogen, lower alkyl, lower alkoxy or halogen (hereinafter referred to as “R4 is R4-2”), or R4 and R1 taken together may form —OCH2O—,
    7) a compound wherein R5 is hydrogen, optionally substituted lower alkoxy, lower alkoxycarbonyl or carboxy (hereinafter referred to as “R5 is R5-1”), preferably R5 is hydrogen, lower alkoxycarbonyl or carboxy (hereinafter referred to as “R5 is R5-2”), more preferably R5 is hydrogen (hereinafter referred to as “R5 is R5-3”),
    8) a compound wherein R6 is hydrogen, halogen, optionally substituted lower alkyl, carboxy, lower alkoxycarbonyl, nitro, formyl, amino or lower alkylsulfonyloxy (hereinafter referred to as “R6 is R6-1”), preferably R6 is hydrogen or lower alkyl or halogen (hereinafter referred to as “R6 is R6-2”),
    more preferably R6 is hydrogen, alkyl having 1 to 3 carbon atoms or halogen (hereinafter referred to as “R6 is R6-3”),
    9) a compound wherein R7 is hydrogen, halogen, optionally substituted lower alkyl, optionally substituted lower alkoxy, formyl or optionally substituted amino (hereinafter referred to as “R7 is R7-1”),
    preferably R7 is hydrogen, lower alkyl or lower alkoxy (hereinafter referred to as “R7 is R7-2”),
    10) a compound wherein R8 is hydrogen, halogen, optionally substituted lower alkyl, optionally substituted lower alkoxy, formyl or optionally substituted amino (hereinafter referred to as “R8 is R8-1”) or R8 and R9 taken together may form a 5- or 6-membered ring which contains one or more of O and which may optionally be substituted, preferably R8 is hydrogen, lower alkyl or lower alkoxy (hereinafter referred to as “R8 is R8-2”),
    11) a compound wherein R9 is hydrogen, hydroxy, carboxy, optionally substituted lower alkyl, optionally substituted lower alkoxy, optionally substituted lower alkenyl, optionally substituted lower alkoxycarbonyl, optionally substituted lower alkylsulfonyloxy, formyl, optionally substituted carbamoyl or optionally substituted amino (hereinafter referred to as “R9 is R9-1”) or R9 and R8 taken together may form a 5- or 6-membered ring which contains one or more of 0 and which may optionally be substituted,
    preferably R9 is hydrogen, hydroxy, carboxy, optionally substituted lower alkyl, optionally substituted lower alkoxy, optionally substituted lower alkenyl, optionally substituted lower alkoxycarbonyl, optionally substituted lower alkylsulfonyloxy, formyl, optionally substituted carbamoyl or optionally substituted amino (hereinafter referred to as “R9 is R9-2”),
    more preferably R9 is hydrogen, hydroxy, lower alkyl, hydroxy(lower)alkyl, lower alkoxycarbonyl(lower)alkenyl, lower alkoxy(lower)alkoxy, lower alkylsulfonyloxy, di(lower)alkylcarbamoyl, carboxy, lower alkoxycarbonyl or amino (hereinafter referred to as “R9 is R9-3”),
    most preferably R9 is hydrogen, hydroxy, methyl, hydroxymethyl, ethoxycarbonylvinyl, methoxymethyloxy, methanesulfonyl, dimethylcarbamoyl, carboxy, methoxycarbonyl or amino (hereinafter referred to as “R9 is R9-4”),
    12) a compound wherein R10 is hydrogen or lower alkoxy (hereinafter referred to as “R10 is R10-1”), preferably R10 is hydrogen (hereinafter referred to as “R10 is R10-2”),
    13) a compound wherein R11 is hydrogen, halogen, optionally substituted lower alkyl, carboxy, lower alkoxycarbonyl, optionally substituted lower alkylsulfonyloxy, formyl, nitro or amino (hereinafter referred to as “R11 is R11-1”) or R11 and —X—Y taken together form a 5- or 6-membered ring which contains one or more of O or NR15 wherein R15 is the same as defined above and which may optionally be substituted with lower alkenyl, halogeno(lower)alkenyl or the like,
    preferably R11 is hydrogen or halogen (hereinafter referred to as “R11 is R11-2”),
    14) a compound wherein R12 is hydrogen,
    15) a compound wherein R13 is hydrogen, hydroxy, halogen, carboxy, optionally substituted lower alkyl, optionally substituted lower alkoxy, optionally substituted lower alkenyloxy, optionally substituted acyloxy, optionally substituted lower alkylsulfonyloxy, formyl, nitro or optionally substituted amino (hereinafter referred to as “R13 is R13-1”) or R13 and —X—Y taken together form a 5- or 6-membered ring which contains one or more of O or NR15 wherein R15 is the same as defined above and which may optionally be substituted with lower alkenyl, halogeno(lower)alkenyl or the like,
    preferably R13 is hydrogen, hydroxy, halogen, carboxy, optionally substituted lower alkyl, optionally substituted lower alkoxy, optionally substituted acyloxy, optionally substituted lower alkylsulfonyloxy, formyl or optionally substituted amino (hereinafter referred to as “R13 is R13-2”),
    more preferably R13 is hydroxy; halogen; lower alkyl optionally substituted with hydroxy or halogen; lower alkoxy optionally substituted with lower alkoxycarbonyl or lower alkoxy; lower alkenyloxy optionally substituted with halogen; aroyloxyl; lower alkylsulfonyloxy; formyl or amino (hereinafter referred to as “R13 is R13-3”), most preferably R13 is hydroxy, fluorine, methyl, hydroxymethyl, iodomethyl, methoxy, ethoxy, isopropyloxy, ethoxycarbonylmethyloxy, methoxymethyloxy, chlorobutenyloxy, bromopropenyloxy, chloropropenyloxy, bromobutenyloxy, dichloropropenyloxy, ethoxycarbonyl, benzoyloxy, methanesulfonyloxy, formyl or amino (hereinafter referred to as “R13 is R13-4”),
    16) a compound wherein X is —O—, —NR14— or —S(O)p— wherein p is an integer of 0 to 2 (hereinafter referred to as “X is X1”), or X, R13 and Y taken together may form a 5- or 6-membered ring which contains one or more of O or NR15 wherein R15 is the same as defined above and may optionally be substituted,
    preferably X is —O—, —NH—, —NMe— or —SO2— (hereinafter referred to as “X is X2”),
    more preferably X is —O—, —NH— or —NMe— (hereinafter referred to as “X is X3”),
    most preferably X is —O—,
    17) a compound wherein Y is optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl, optionally substituted cycloalkenyl, lower alkylsulfonyl, optionally substituted arylsulfonyl, lower alkoxycarbonyl or optionally substituted acyl (hereinafter referred to as “Y is Y1”), or Y, R13 and X taken together may form a 5- or 6-membered ring which contains one or more of O or NR15 wherein R15 is the same as defined above and which may optionally be substituted, preferably Y is lower alkyl optionally substituted with halogen; hydroxy; amino optionally substituted with lower alkyl; lower alkoxy; carboxy; lower alkoxycarbonyl; acyl; cycloalkyl; cycloalkenyl; cyano; imino optionally substituted with hydroxy, lower alkoxy, carboxy(lower)alkoxy, aryl(lower)alkoxy or heterocyclyl; hydrazono optionally substituted with carbamoyl or lower alkoxycarbonyl; carbamoyl optionally substituted with lower alkyl or amino; thiocarbamoyl optionally substituted with lower alkyl; aryl optionally substituted with amino (optionally substituted with lower alkyl, acyl, lower alkoxycarbonyl or lower alkylsulfonyl), nitro, acyloxy, lower alkyl (optionally substituted with halogen or carboxy), halogen, lower alkoxy, carboxy, lower alkoxycarbonyl, lower alkenyloxycarbonyl or guanidino; or heterocyclyl optionally substituted with halogen or lower alkyl; lower alkenyl optionally substituted with halogen, hydroxy, cycloalkyl, lower alkoxycarbonyl or aryl-substituted heterocyclyl; lower alkynyl optionally substituted with halogen; or cycloalkenyl (hereinafter referred to as “Y is Y2”), more preferably Y is lower alkyl optionally substituted with lower alkoxycarbonyl, aryl, lower alkylaryl, halogenoaryl, lower alkoxyaryl, heterocyclyl or acyl; or lower alkenyl optionally substituted with hydroxy, halogen or aryl (hereinafter referred to as “Y is Y3”),

most preferably Y is isopropyl, ethoxycarbonylmethyl, benzyl, methylphenylmethyl, fluorophenylmethyl, dichlorophenylmethyl, methoxyphenylmethyl, pyridylmethyl, benzoylmethyl, propenyl, methylpropenyl, methylbutenyl, hydroxymethylbutenyl, pentenyl, methylpentenyl, dimethyloctadienyl, chloropropenyl, dichloropropenyl, bromopropenyl, dibromopropenyl, fluoropropenyl, difluoropropenyl, butenyl, bromobutenyl, chlorobutenyl or phenylpropenyl (hereinafter referred to as “Y is Y4”),

    18) a compound wherein R1 is R1-2, R2 is R2-1, R3 is R3-1, R4 is R4-1, R5 is R5-1, R6 is R6-1, R7 is R7-1, R8 is R8-1, R9 is R9-2, R10 is R10-1, R11 is R11-1, R12 is hydrogen, R13 is R13-1, X is X1 and Y is Y1, and R1 and R2, R1 and R4, R8 and R9, or R13 and —X—Y taken together may form a 5- or 6-membered ring which contains one or more of O or NR15 wherein R15 is the same as defined above and which may optionally be substituted,
    19) a compound wherein R1 is R1-2, R2 is R2-1, R3 is R3-1, R4 is R4-1, R5 is R5-1, R6 is R6-1, R7 is R7-1, R8 is R8-1, R9 is R9-1, R10 is R10-1, R11 is R11-1, R12 is hydrogen, R13 is R13-2, X is X1 and Y is Y1, and R1 and R2, R1 and R4, R8 and R9, or R13 and —X—Y taken together may form a 5- or 6-membered ring which contains one or more of O or NR15 wherein R15 is the same as defined above and which may optionally be substituted,
    20) a compound wherein R1 is R1-2, R2 is R2-1, R3 is R3-1, R4 is R4-1, R5 is R5-1, R6 is R6-2, R7 is R7-2, R8 is R8-2, R9 is R9-1, R10 is R10-1, R11 is R11-1, R12 is hydrogen, R13 is R13-1, X is X1 and Y is Y2, and R1 and R2, R1 and R4, R8 and R9, or R13 and —X—Y taken together may form a 5- or 6-membered ring which contains one or more of O or NR15 wherein R15 is the same as defined above and which may optionally be substituted,
    21) a compound wherein R1 is R1-1, R2 is R2-1, R3 is R3-1, R4 is R4-1, R5 is R5-1, R6 is R6-2, R7 is R7-1, R8 is R8-2, R9 is R9-2, R10 is R10-1, R11 is R11-1, R12 is hydrogen, R13 is R13-2, X is X1 and Y is Y1, and R1 and R2, R1 and R4, R8 and R9, or R13 and —X—Y taken together may form a 5- or 6-membered ring which contains one or more of O or NR15 wherein R15 is the same as defined above and which may optionally be substituted,
    22) a compound wherein R1 is R1-1, R2 is R2-1, R3 is R3-1, R4 is R4-1, R5 is R5-1, R6 is R6-2, R7 is R-7-1, R8 is R8-2, R9 is R9-2, R10 is R10-1, R11 is R11-1, R12 is hydrogen, R13 is R13-1, X is X1 and Y is Y2, and R1 and R2, R1 and R4, R8 and R9, or R13 and —X—Y taken together may form a 5- or 6-membered ring which contains one or more of O or NR15 wherein R15 is the same as defined above and which may optionally be substituted,
    23) a compound wherein R1 is R1-1, R2 is R2-1, R3 is R3-1, R4 is R4-1, R5 is R5-1, R6 is R6-2, R7 is R7-1, R8 is R8-2, R9 is R9-1, R10 is R10-1, R11 is R11-1, R12 is hydrogen, R13 is R13-2, X is X1 and Y is Y2, and R1 and R2, R1 and R4, R8 and R9 or R13 and —X—Y taken together may form a 5- or 6-membered ring which contains one or more of O or NR15 wherein R15 is the same as defined above and which may optionally be substituted,
    24) a compound wherein R1 is R1-2, R2 is R2-1, R3 is R3-1, R4 is R4-1, R5 is R5-1, R6 is R6-2; R7 is R7-1, R8 is R8-2, R9 is R9-2, R10 is R10-1, R11 is R11-1, R12 is hydrogen, R13 is R13-2, X is X1 and Y is Y1, and R1 and R2, R1 and R4, R8 and R9, or R13 and —X—Y taken together may form a 5- or 6-membered ring which contains one or more of 0 or NR15 wherein R15 is the same as defined above and which may optionally be substituted,
    25) a compound wherein R1 is R1-2, R2 is R2-1, R3 is R3-1, R4 is R4-1, R5 is R5-1, R6 is R6-2, R7 is R7-1, R8 is R8-2, R9 is R9-2, R10 is R10-1, R11 is R1-1, R12 is hydrogen, R13 is R13-1, X is X1 and Y is Y2, and R1 and R2, R1 and R4, R8 and R9, or R13 and —X—Y taken together may form a 5- or 6-membered ring which contains one or more of O or NR15 wherein R15 is the same as defined above and which may optionally be substituted,
    26) a compound wherein R1 is R1-2, R2 is R2-1, R3 is R3-1, R4 is R4-1, R5 is R5-1, R6 is R6-2, R7 is R7-1, R8 is R8-2, R9 is R9-1, R10 is R10-1, R11 is R11-1, R12 is hydrogen, R13 is R13-2, X is X1 and Y is Y2, and R1 and R2, R1 and R4, R8 and R9, or R13 and —X—Y taken together may form a 5- or 6-membered ring which contains one or more of O or NR15 wherein R15 is the same as defined above and which may optionally be substituted,
    27) a compound wherein R1 is R1-1, R2 is R2-1, R3 is R3-1, R4 is R4-1, R5 is R5-1, R6 is R6-2, R7 is R7-1, R8 is R8-2, R9 is R9-2, R10 is R10-1, R11 is R11-1, R12 is hydrogen, R13 is R13-2, X is X1 and Y is Y2, and R1 and R2, R1 and R4, R8 and R9, or R13 and —X—Y taken together may form a 5- or 6-membered ring which contains one or more of O or NR15 wherein R15 is the same as defined above and which may optionally be substituted,
    28) a compound wherein R1 is R1-2, R2 is R2-2, R3 is R3-2, R4 is R4-2, R5 is R5-2, R6 is R6-2, R7 is R7-2, R8 is R8-2, R9 is R9-2, R10 is R10-2, R11 is R11-2, R12 is hydrogen, R13 is R13-2, X is X2 and Y is Y2, and R1 and R4, or R8 and R9 taken together may form a 5- or 6-membered ring which contains one or more of O,
    29) a compound wherein R1 is R1-3, R2 is R2-2, R3 is R3-2, R4 is R4-2, R5 is R5-2, R6 is R6-2, R7 is R7-2, R8 is R8-2, R9 is R9-2, R10 is R10-2, R11 is R11-2, and R1 and R4, or R8 and R9 taken together may form a 5- or 6-membered ring which contains one or more of O,
    30) a compound wherein R1 is R1-4, R2 is R2-2, R3 is R3-2, R4 is R4-2, R5 is R5-2, R6 is R6-2, R7 is R7-2, R8 is R8-2, R9 is R9-2, R10 is R10-2, R11 is R11-2, R12 is hydrogen, R13 is R13-2, X is X2 and Y is Y2, and R1 and R4, or R8 and R9 taken together may form —OCH2O—,
    31) a compound wherein R1 is R1-2, R2 is R2-2, R3 is R3-2, R4 is R4-2, R5 is R5-2, R6 is R6-2, R7 is R7-2, R8 is R8-2, R9 is R9-3, R10 is R10-2, R11 is R11-2, R12 is hydrogen, R13 is R13-2, X is X2 and Y is Y2, and R1 and R4, or R8 and R9 taken together may form a 5- or 6-membered ring which contains one or more of O,
    32) a compound wherein R1 is R1-2, R2 is R2-2, R3 is R3-2, R4 is R4-2, R5 is R5-2, R6 is R6-2, R7 is R7-2, R8 is R8-2, R9 is R9-4, R10 is R10-2, R11 is R11-2, R12 is hydrogen, R13 is R13-2, X is X2 and Y is Y2, and R1 and R4, or R8 and R9 taken together may form a 5- or 6-membered ring which contains one or more of O,
    33) a compound wherein R1 is R1-2, R2 is R2-2, R3 is R3-2, R4 is R4-2, R5 is R5-2, R6 is R6-2, R7 is R7-2, R8 is R8-2, R9 is R9-2, R10 is R10-2, R11 is R11-2, R12 is hydrogen, R13 is R13-3, X is X2 and Y is Y2, and R1 and R4, or R8 and R9 taken together may form a 5- or 6-membered ring which contains one or more of O,
    34) a compound wherein R1 is R1-2, R2 is R2-2, R3 is R3-2, R4 is R4-2, R5 is R5-2, R6 is R6-2, R7 is R7-2, R8 is R8-2, R9 is R9-2, R10 is R10-2, R11 is R11-2, R12 is hydrogen, R13 is R13-4, X is X2 and Y is Y2, and R1 and R4, or R8 and R9 taken together may form a 5- or 6-membered ring which contains one or more of O,
    35) a compound wherein R1 is R1-2, R2 is R2-2, R3 is R3-2, R4 is R4-2, R5 is R5-2, R6 is R6-2, R7 is R7-2, R8 is R8-2, R9 is R9-2, R10 is R10-2, R11 is R1′-2, R12 is hydrogen, R13 is R13-2, X is X2 and Y is Y3, and R1 and R4, or R8 and R9 taken together may form
    a 5- or 6-membered ring which contains one or more of O,
    36) a compound wherein R1 is R1-3, R2 is R2-2, R3 is R3-2, R4 is R4-2, R5 is R5-2, R6 is R6-2, R7 is R7-2, R8 is R8-2, R9 is R9-3, R10 is R10-2, R11 is R11-2, R12 is hydrogen, R13 is R13-2, X is X2 and Y is Y2, and R1 and R4, or R8 and R9 taken together may form a 5- or 6-membered ring which contains one or more of O,
    37) a compound wherein R1 is R1-3, R2 is R2-2, R3 is R3-2, R4 is R4-2, R5 is R5-2, R6 is R6-2, R7 is R7-2, R8 is R8-2, R9 is R9-2, R10 is R10-2, R11 is R11-2, R12 is hydrogen, R13 is R13-3, X is X2 and Y is Y2, and R1 and R4, or R8 and R9 taken together may form a 5- or 6-membered ring which contains one or more of O,
    38) a compound wherein R1 is R1-3, R2 is R2-2, R3 is R3-2, R4 is R4-2, R5 is R5-2, R6 is R6-2, R7 is R7-2, R8 is R8-2, R9 is R9-2, R10 is R10-2, R11 is R11-2, R12 is hydrogen, R13 is R13-2, X is X2 and Y is Y3, and R1 and R4, or R8 and R9 taken together may form a 5- or 6-membered ring which contains one or more of O,
    39) a compound wherein R1 is R1-2, R2 is R2-2, R3 is R3-2, R4 is R4-2, R5 is R5-2, R6 is R6-2, R7 is R7-2, R8 is R8-2, R9 is R9-3, R10 is R10-2, R11 is R11-2, R12 is hydrogen, R13 is R13-3, X is X2 and Y is Y2, and R1 and R4, or R8 and R9 taken together may form a 5- or 6-membered ring which contains one or more of O,
    40) a compound wherein R1 is R1-2, R2 is R2-2, R3 is R3-2, R4 is R4-2, R5 is R5-2, R6 is R6-3, R7 is R7-2, R8 is R8-2, R9 is R9-3, R10 is R10-2, R11 is R11-2, R12 is hydrogen, R13 is R13-2, X is X2 and Y is Y3, and R1 and R4, or R8 and R9 taken together may form a 5- or 6-membered ring which contains one or more of O,
    41) a compound wherein R1 is R1-2, R2 is R2-2, R3 is R3-2, R4 is R4-2, R5 is R5-2, R6 is R6-2, R7 is R7-2, R8 is R8-2, R9 is R9-2, R10 is R10-2, R11 is R11-2, R12 is hydrogen, R13 is R13-3, X is X2 and Y is Y3, and R1 and R4, or R8 and R9 taken together may form a 5- or 6-membered ring which contains one or more of O,
    42) a compound wherein R1 is R1-3, R2 is R2-2, R3 is R3-2, R4 is R4-2, R5 is R5-2, R6 is R6-2, R7 is R7-2, R8 is R8-2, R9 is R9-3, R10 is R10-2, R1 is R11-2, R12 is hydrogen, R13 is R13-3, X is X2 and Y is Y2, and R1 and R4, or R8 and R9 taken together may form —OCH2O—,
    43) a compound wherein R1 is R1-3, R2 is R2-2, R3 is R3-2, R4 is R4-2, R5 is R5-2, R6 is R6-2, R7 is R7-2, R8 is R8-2, R9 is R9-3, R10 is R10-2, R11 is R11-2, R12 is hydrogen, R13 is R13-2, X is X2 and Y is Y3, and R1 and R4, or R8 and R9 taken together may form —OCH2O—,
    44) a compound wherein R1 is R1-3, R2 is R2-2, R3 is R3-3, R4 is R4-2, R5 is R5-2, R6 is R6-2, R7 is R7-2, R8 is R8-2, R9 is R9-2, R10 is R10-2, R11 is R11-2, R12 is hydrogen, R13 is R13-3, X is X2 and Y is Y3, and R1 and R4, or R8 and R9 taken together may form —OCH2O—,
    45) a compound wherein R1 is R1-2, R2 is R2-2, R3 is R3-3, R4 is R4-2, R5 is R5-3, R6 is R6-2, R7 is R7-2, R8 is R8-2, R9 is R9-3, R10 is R10-2, R11 is R11-2, R12 is hydrogen, R13 is R13-3, X is X2 and Y is Y3, and R1 and R4, or R8 and R9 taken together may form a 5- or 6-membered ring which contain one or more of O,
    46) a compound wherein R1 is R1-3, R2 is R2-2, R3 is R3-3, R4 is R4-2, R5 is R5-3, R6 is R6-3, R7 is R7-2, R8 is R8-2, R9 is R9-3, R10 is R10-2, R11 is R11-2, R12 is hydrogen, R13 is R13-3, X is X3 and Y is Y4, and R1 and R4, or R8 and R9 taken together may form —OCH2O—,
    47) a compound wherein R1 is R1-4, R2 is R2-2, R3 is R3-3, R4 is R4-2, R5 is R5-3, R6 is R6-3, R7 is R7-2, R8 is R8-2, R9 is R9-4, R10 is R10-2, R11 is R11-2, R12 is hydrogen, R13 is R13-4, X is X3 and Y is Y4, R1 and R4 taken together may form —OCH2O— and R8 and R9 taken together may form —OCH2CH2O—,
    48) a compound wherein the benzene ring which is substituted with R1–R5 is









    49) a compound wherein the benzene ring which is substituted with R6–R9 is









    50) a compound wherein the benzene ring which is substituted with R10–R13 is






    51) a compound wherein Y is —CH2CH═CMe2, —(CH2)2CH═CMe2, —CH2CH═CCl2, —CH2CH═CBr2, —CH2CH═CF2, —CH2CH═CHMe, —CH2CH═C(Me)CH2OH, —CH2C≡CMe, —CH2C6H4—4-Me, —CH2C6H5, —CH2CH2CHMe2 or —Me,
    52) a compound wherein —X—Y is —OCH2CH═CMe2, —O(CH2)2CH═CMe2, —OCH2CH═CCl2, —OCH2CH═CBr2, —OCH2CH═CF2, —OCH2C≡CMe, —OCH2C6H4-4-Me, —OCH2C6H5, —NHCH2CH═CMe2, —N(Me)CH2CH═CMe2, —NHCH2CH2CHMe2, —NHCH2C≡CH, or —NMe2, or
    53) a compound wherein at least seven of the substituents of R1–R13 are hydrogen, preferably at least eight are hydrogen, more preferably at least nine are hydrogen, and their pharmaceutically acceptable salts, their hydrates and their prodrugs.


A process for producing the compound (I′′′) is as follows.
Process for Producing the Compound (I′′′) [Process a]
The compound (I′′′) can be produced by the reaction of a borane compound of the formula (II) and (II′) coupled with a biphenyl derivative of the formula (III) and (III′) respectively, as shown below.




wherein R1–R13, X and Y are the same as defined in the above formula (I′′′), and A and Z are the same as defined in the above formulas (II) and (III), or





wherein R1–R13, X and Y are the same as defined in the above formula (I′′′), and A and Z are the same as defined in the above formulas (II) and (III).

The compounds (II) and (II′) are reacted with the compounds (III) and (III′) respectively in a mixture system of an appropriate solvent such as benzene, toluene, dimethylformamide, dimethoxyethane, tetrahydrofuran, dioxane, ethanol, methanol or the like and water or in an anhydrous system in the presence of a palladium catalyst such as Pd(PPh3)4, PdCl2(PPh3)2, PdCl2(OAc)2, PdCl2(CH3CN)2 or the like, preferably Pd(PPh3)4, under a basic condition (for example, by K3PO4, NaHCO3, NaOEt, Na2CO3, Et4NCl, Ba(OH)2, Cs2CO3, CsF, NaOH, Ag2CO3 or the like) at room temperature or with heating for several tens minutes to several tens hours to obtain the compound (I′′′).
One of substituents A and Z of the compounds to be reacted may be any of the borane groups which are applicable in the Suzuki Reaction (Chemical Communication 1979, 866, Journal of Synthetic Organic Chemistry, Japan, 1993, Vol. 51, No.11, 91–100) and dihydroxyborane is preferable. The other may be any of the leaving groups which are applicable in the Suzuki Reaction, for example, halogen, —OSO2(CqF2q+1) wherein q is an integer of 0 to 4, or the like. Specifically, halogen, trifluoromethanesulfonyloxy (hereinafter referred to as OTf) or the like is preferable and bromine, iodine or OTf is more preferable.
The substituents R1–R13 and —X—Y of the compounds (II), (III), (II′) and (III′) may be any of the groups which do not affect the Suzuki Reaction, for example, any groups other than halogen and —OSO2(CqF2q+1) wherein q is an integer of 0 to 4.
For example, Y may be optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl, optionally substituted acyl, optionally substituted cycloalkyl, optionally substituted cycloalkenyl, optionally substituted aryl or optionally substituted heterocyclyl, Y may be optionally substituted lower alkoxy when X is —CH2— and Y may be optionally substituted lower alkoxycarbonyl, optionally substituted lower alkylsulfonyl or optionally substituted arylsulfonyl when X is −O— or NR14—. Even if R1–R13 or Y is halogen, these reactions can be carried out without difficulty when the reactivity of the substituent A with the substituent Z is higher than that of halogen with either of substituents A and Z.
Even if one of R1–R13 and —X—Y is hydroxy, the above reactions can be carried out preferably after the protection of hydroxy group with a usual hydroxy-protecting group (for example, metoxymethyl, benzyl, tert-butyldimethylsilyl, methansulfonyl, p-toluenesulfonyl or the like), followed by the removal of them by usual methods.
As processes for producing the compound (I′′′), the above mentioned Suzuki Reaction is most preferable in view of the efficiency and easiness but silicon, zinc, tin or the like can be used in place of the borane group in the above scheme.
For example, in the case that one of A and Z is —SiR173-r (Hal)r wherein R17 is independently lower alkyl, Hal is halogen and r is an integer of 1 to 3 and the other is halogen or —OSO2(CqF2q+1) wherein q is an integer of 0 to 4, the coupling reaction may be carried out using a usual palladium catalyst (Synlett (1991) 845–853, J. Org. Chem. 1996, 61, 7232–7233). Examples of preferable palladium catalysts are (i—Pr3P)2PdCl2, [(dcpe)PdCl2] (dcpe=Cy2PCH2CH2PCy2), (η3—C3H5PdCl)2 and the like.
Even in the case that one of A and Z is —SnR183 wherein R18 is each independently lower alkyl and the other is halogen, acetyloxy or —OSO2(CqF2q+1) wherein q is an integer of 0 to 4, an objective compound can be obtained using a usual palladium catalyst (preferably Pd(PPh3)4 or the like) (Angew. Chem. Int. Ed. Engl. 25 (1986) 508–524).
In the case that one of A and Z is —Zn(Hal) wherein Hal is halogen and the other is halogen, an objective compound can be obtained (Acc. Chem. Res. 1982, 15, 340–348). Any usual palladium catalyst is applicable and Pd(PPh3)4, PdCl2(dppf), PdCl2(PPh3)2, PdCl2(P(o-Tolyl)3)2, Pd(OAc)2 and the like are exemplified as preferable examples.
All of these reactions may be carried out in a suitable solvent (for example, dimethylformamide, tetrahydrofuran or the like) at room temperature or with heating for several tens minutes to several tens hours.
Process for Producing the Compound (I′′′) [Process b]
As another easier processes for producing the compound (I′′′), the following process wherein the compound of the formulas (IV), (V) and (VI) are coupled is also applicable.




wherein R1–R13, X and Y are the same as defined in the above formulas (1), (II) and (III) and A1, A2, Z1 and Z2 are the same as defined in the above A and Z, respectively. The reactivity of A1 is higher than or equal to that of A2 in the compound (IV) and the reactivity of A2 is higher than or equal to that of A1 in the compound (IV′).

For production of the compound (I′′′) by the above process the compound (IV) may be reacted with the compound (V), followed by the reaction with the compound (VI) without an isolation. The objective compound can be obtained also by a process wherein the compound (IV′) is reacted with the compound (VI), followed by a reaction with the compound (V).
Because the reactions of the substituents A1 and Z1 and the substituents A2 and Z2 are necessary to obtain the objective compound, the reactivity of the substituent A1 and that of A2 should be different. A preferable example is the combination that A1 is iodine and A2 is bromine or —OTf in the compound (IV). Conversely in the compound (IV′) iodine for A2 and bromine or —OTf for A1 are preferable. In the case that the compound (IV) or (IV′) is a symmetry compound, the objective compound is obtained even if A1 and A2 are the same group.
The substituents Z1 and Z2 may be the same or different group.
Various other conditions in this process are the same as those in the “Process a”.
In the above compounds, the substituents R1–R13 may be any of the groups which do not affect the reaction (for example, a group other than halogen and —OSO2(CqF2q+1) wherein q is an integer of 0 to 4) or any of the groups which do not affect the reaction and are changeable to R1, R13 by a usual reaction. In the latter case the substituents may be changed to R1–R13 in suitable steps according to the reaction of each compound.
For example, in the case that a substituent is formyl and an objective substituent is hydroxy, after the substituent is changed to formyloxy by the Baeyer-Villiger reaction etc., a usual hydrolysis reaction may be carried out under an acidic or alkaline condition. Specifically, a compound which has formyl is reacted with a peroxy acid such as peracetic acid, perbenzoic acid, m-chloroperbenzoic acid, trifluoroperacetic acid, hydrogen peroxide or the like in a suitable solvent such as 1,2-dichloroethane, chloroform, dichloromethane, carbon tetrachloride, benzene or the like at −20° C. or with heating for several minutes to several tens hours, followed by the hydrolysis of the obtained compound which has formyloxy under an acidic condition (for example, with heating with hydrochloric acid) or under a basic condition (for example, with heating with sodium hydroxide).
In the case that a substituent is formyl and an objective substituent is hydroxymethyl, the compound which has formyl may be reacted with a reductant such as sodium borohydride, lithium borohydride, zinc borohydride, triethyllithium borohydride, alminium hydride, diisobutylalminium hydride or the like in a solvent (for example, methanol, ethanol, isopropanol, dimethylsulfoxide, diethylene glycol dimethoxyethane, tetrahydrofuran, benzene, toluene, cyclohexane or the like) which is suitable for the reductant at  ̃20° C. to 80° C., preferably under ice-cooling or at room temperature, for several tens minutes to several hours.
In the case that a substituent is formyl and an objective substituent is alkenyl having additional carbon atoms, an objective compound can be obtained by the Wittig Reaction (Organic Reaction, 1965, vol. 14, p. 270).
In the case that a substituent is formyl and an objective substituent is carboxy, the compound which has formyl may be reacted with an oxidizing agent such as sodium chlorite, the Jones Reagent, chromic anhydride or the like in a solvent such as tert-butanol, acetone or the like which is suitable for the oxidizing agent at 0° C. or with heating for several hours. The reaction is preferably carried out by addition of 2-methyl-2-buten, sodium dihydrogenphosphate or the like if needed.
In the case that a substituent is hydroxy and an objective substituent is substituted lower alkoxy, the compound which has hydroxy may be reacted with a proper alkylating agent in the presence of a base such as sodium carbonate, sodium bicarbonate, potassium carbonate, calcium hydroxide, barium hydroxide, calcium carbonate or the like in a suitable solvent such as tetrahydrofuran, acetone, dimethylformamide, acetonitrile or the like. Specifically, the reaction of a compound which has hydroxy with a proper halogenated compound such as methyl iodoacetate, ethyl chloroacetate, propyl chloroacetate or the like can give a compound of which substituent is alkoxycarbonyl(lower)alkoxy.
In the case that a substituent is carboxy and an objective substituent is carbamoyl, the compound which has carboxy may be carbamoylated with an amine such as ammonia, dimethylamine or the like at 0° C. or with heating for several minutes to several hours in a suitable solvent such as tetrahydrofuran, dimethylformamide, diethyl ether, dichloromethane or the like, if necessary after activation by an activating agent such as thionyl chloride, an acid halide, an acid anhydride, an activated ester or the like.
In the case that a substituent is hydrogen and an objective substituent is halogen, the compound which has hydrogen may be halogenated by a halogenating agent which is generally used (for example, bromine, chlorine, iodine, sulfuryl chloride, N-bromosuccinimide, N-iodosuccinimide or the like) in a suitable solvent such as chloroform, dichloromethane, carbon tetrachloride, acetonitrile, nitromethane, acetic acid, acetic anhydride or the like, if necessary in the presence of a catalyst such as the Lewis acid, hydrochloric acid, phosphoric acid or the like at −20° C. or with heating for several minutes to several tens hours.
The compound (I) can be obtained by a reaction of the compound (II) which has a substituent —X—Y with the compound (III) or a reaction of the compound (III′) which has a substituent —X—Y with the compound (II′). Further, the compound (I) can also be obtained by a reaction of the compound (II) or (III′) which has a substituent —W which is convertible into a substituent —X—Y with the compound (III) or (II′), followed by a conversion of a substituent —W into a substituent —X—Y.
For example, in the case of a compound wherein —W is hydroxy or protected hydroxy, an objective substituent such as lower alkyl, lower alkenyl, lower alkynyl, acyl, cycloalkyl, cycloalkenyl, aryl, heterocyclyl, lower alkoxy or the like may be introduced by a usual reaction.
Concretely, to obtain a compound wherein X is —O—, a compound wherein —W is hydroxy is synthesized and dissolved in a suitable solvent (for example, dimethylformamide, tetrahydrofuran, acetone, benzene, dioxane, acetonitrile or the like), followed by addition of a base such as hydroxides or carbonates of alkaline metals or alkaline-earth metals (for example, sodium carbonate, sodium bicarbonate, potassium carbonate, calcium hydroxide, barium hydroxide, calcium carbonate and the like) or tertiary amines such as triethylamine and the like. To the reactant is added a compound Y—V wherein V is halogen or —OSO2(CqF2q+1) wherein q is an integer of 0–4 (for example, prenyl bromide, cyclohexenyl bromide, cinnamyl bromide, 1-bromo-2-penten, geranyl bromide, 5-bromo-2-methyl-2-penten, 1,3-dichloro-2-buten, 3-chloropropyne, prenyl triflate, cyclohexenyl triflate, 1,3-trichloropropene or the like) at 20° C. or with heating for several minutes to several tens hours to obtain an objective compound wherein —W has been converted into —O—Y.
To obtain a compound wherein X is —CH2—, —NHR14- or —S—, a compound wherein —W is hydroxy is reacted with trifluoromethanesulfonic anhydride etc. in a solvent such as anhydrous dichloromethane, chloroform, carbon tetrachloride or the like in the presence of a base such as pyridine, triethylamine or the like to obtain a triflate. Then, the obtained compound is reacted with Y—V′ wherein V′ is —CH2ZnI, —SH, —NHR14 in the presence of a catalyst such as palladium, nickel or the like in a suitable solvent such as tetrahydrofuran, dimethylformamide, diethyl ether, dimethoxyethane or the like to give an objective compound.
In the case that X is NR14, a compound wherein W is NH2 may be reacted with a ketone or an aldehyde in a suitable solvent such as tetrahydrofuran, methanol or the like, followed by reduction with a suitable reductant such as sodium borohydride, sodium cyanoborohydride, zinc hydrochloride or the like or by catalytic reduction to obtain an objective compound.
A usual reaction of a compound wherein W is NH2 with Y—V′′ wherein Y is acyl, lower alkylsulfonyl optionally substituted or arylsulfonyl optionally substituted and V′′ is a leaving group such as halogen gives a compound wherein —X—Y is —NH—Y.
To obtain a compound wherein X is —SO— or —SO2—, a compound wherein X is —S— which is synthesized by the above mentioned process may be oxidized with a usual oxidizing agent such as m-chloroperbenzoic acid.
A compound of the present invention wherein —X—Y is lower alkenyloxy is dissolved in a solvent such as ethanol, ethyl acetate or the like and hydrogenated with a catalyst such as Pd-carbon powder, platinum, rhodium, ruthenium, nickel or the like to give a compound wherein —X—Y is lower alkoxy.
A reaction of a compound wherein —X—Y is lower alkenyloxy with m-chloroperbenzoic acid or the like in a solvent such as dichloromethane, chloroform, benzene, hexane, tert-butanol or the like gives a compound wherein —X—Y is epoxidated lower alkoxy.
In the case that a compound has a substituent interfering of a reaction, the substituent may be protected with a suitable protecting group in advance and the protecting group may be left in a suitable step by a usual method. For example, if hydroxy interferes the reaction, hydroxy may be protected with methoxymethyl, methanesulfonyl, benzyl, trifluoromethanesulfonyl, tert-butyldimethylsilyl or the like, followed by deprotection in a suitable step.
For example, for a protection of hydroxy with methanesulfonyl, a compound which has hydroxy may be reacted with methanesulfonyl chloride in a solvent such as dichloromethane, chloroform, carbon tetrachloride or the like in the presence of a base such as triethylamine, pyridine or the like under ice-cooling or at room temperature for several hours. The protected compound may be deprotected with 1–4 N sodium hydroxide, potassium hydroxide, aqueous solution thereof, sodium methoxide, ethyl magnesium bromide or the like in a solvent such as dimethylsulfoxide, dimethylformamide, tetrahydrofuran, dioxane, dimethoxyethane or the like at room temperature or with heating for several tens minutes to several hours.
When methoxymethyl is used as a protecting group of hydroxy, a compound which has hydroxy may be reacted with chloromethylmethylether in a solvent such as tetrahydrofuran, dioxane, dimethoxyethane or the like in the presence of sodium hydride, diisopropylethylamine or the like to obtain a compound which has a protected hydroxy group. The compound may be subjected to a usual deprotection reaction with hydrochloric acid, sulfuric acid or the like in a solvent such as methanol, tetrahydrofuran, acetic acid or the like for a deprotection.
When tert-butyldimethylsilyl is used as a protective group, a compound which has hydroxy may be reacted with tert-butyldimethylsilyl chloride, tert-butyldimethylsilyl triflate or the like in a solvent such as dimethylformamide, acetonitrile, tetrahydrofuran, dimethylformamide, dichloromethane or the like in the presence of imidazole, triethylamine, 2,6-lutidine or the like. For a deprotection reaction the protected compound may be reacted with tetrabutylammonium fluoride or the like in a solvent such as tetrahydrofuran or the like.
Both of known compounds and the compounds which are produced by the following process may be used as the compounds (III) and (III′) in the above scheme.




Known compounds (VIII) and (IX), or (VIII′) and (IX′) wherein A and Z are groups which can be subjected to a coupling reaction by the Suzuki Reaction with each other; for example, one is borane such as dihydroxyborane, di(lower)alkoxyborane or the like and the other is halogen or —OSO2(CqF2q+1) wherein q is an integer of 0–4; D is a group other than halogen and —OSO2(CqF2q+1) wherein q is the same as defined above are reacted by the same method as above to obtain a compound (VII) or (VII′).
As described above, instead of a compound which has borane, a compound which has —SiR173-r (Hal)r wherein R17 is each independently lower alkyl, Hal is halogen and r is an integer of 1–3, —SnR183 wherein R18 is each independently lower alkyl or —Zn(Hal) wherein Hal is halogen may be used for a reaction to obtain an objective compound.
Then, a substituent D is converted into a substituent A which is applicable to the Suzuki Reaction.
For example, a compound wherein D is hydrogen may be reacted with a halogenating agent such as bromine, chlorine, iodine, sulfuryl chloride, N-bromosuccinimide or the like in a suitable solvent such as acetic acid, chloroform, dichloromethane, carbon tetrachloride, water, acetic acid-sodium acetate or the like at 20° C. or with heating for several minutes to several tens hours to give an objective compound wherein A is halogen.
A compound wherein D is protected hydroxy may be reacted with a trifluoromethanesulfonating agent such as trifluoromethanesulfonic anhydride, trifluoromethansulfonyl chloride or the like in a suitable solvent such as dichloromethane, chloroform, tetrahydrofuran or benzene in the presence of a base such as pyridine or triethylamine at −20° C. or with heating for several minutes to several tens hours to give an objective compound wherein A is OTf.
A compound of the present invention thus obtained can be converted into prodrug thereof: Any usual methods for conversion into a prodrug may be used. For example, hydroxy or amino which is attached a compound of the present invention at any position may be substituted with a usual group for a prodrug. An example of conversion into a prodrug is a substitution of hydroxy with acyloxy substituted with carboxy, sulfo, amino, lower alkylamino or the like, phosphonoxy etc. A substitution of hydroxy for R1 with OCOCH2CH2COOH, —OCOCH═CHCOOH, —OCOCH2SO3H, —OPO3H2, —OCOCH2NMe2, —OCO-Pyr wherein Pyr is pyridine or the like is preferable.
A selective suppressor of the IgE production of the present invention comprises a compound which suppresses the IgE production in a process from a differentiation of a mature B cell into an antibody-producing cell to the production of an antibody and which does not suppress or weakly suppresses the production of the immunoglobulins IgG, IgM and/or IgA which are produced at the same time.
The term “suppresses the IgE production in a process from a differentiation of a mature B cell into an antibody-producing cell to the production of an antibody” means to suppress the IgE production by inhibiting one of the following processes.

    1) A process wherein mature B cells are activated by various factors such as cytokines, i.e., IL-4, IL-5, etc., anti-CD40 antibody or the like,
    2) A process wherein the activated B cells differentiate into antibody-producing cells such as plasma cells etc. (concretely, a process of switching of the activated B cells to IgE class antibody-producing cells) and/or
    3) A process wherein the antibody-producing cells produce immunoglobulins (specifically, a process of the IgE production)


An inhibition of “a process wherein a mature B cell is activated by various factors” in the process 1) does not include an inhibition of a process wherein the factors are produced from other cells and the like.
The term “suppresses the IgE production and does not suppress or weakly suppresses the production of the immunoglobulins IgG, IgM and/or IgA which are produced at the same time” means that the IgE production is suppressed enough to suppress allergy reactions and that the IgG, IgM and/or IgA production is not suppressed so potent as to badly affect an immune system concerning a living body protection under the condition that IgE and one or more of IgG, IgM and IgA can be produced at the same time. In other words,

    {circle around (1)} The suppression of the IgE production is 5,000 times, preferably 10,000 times, more preferably 15,000 times, most preferably 20,000 times or more as potent as those of the IgG, IgM and/or IgA production and/or
    {circle around (2)} The IgG, IgM and/or IgA production is not suppressed to less than 50% even at 5,000 times, preferably 10,000 times, more preferably 15,000 times, most preferably 20,000 times the concentration at which 50% of the IgE production is suppressed as compared with that in the absence of the suppressor.


The term “the concentration at which 50% of the IgE production is suppressed as compared with that in the absence of the suppressor” means a concentration at which the IgE production is limited to 50% of the production in the absence or without administration of the selective suppressor of the IgE production of the present invention under the condition that the IgE can be produced. The suppressor is useful as a medicament when it has a selectivity for the IgE as compared with at least one of IgG, IgM or IgA, preferably with all of them.
The selective suppressor of the IgE production of the present invention suppresses 90% or more of the IgE production as compared with that without administration of the suppressor at a dosage that the suppressor does not suppress or weakly suppresses the IgM, IgG and/or IgA production when the suppressor is administered to a mammal, which includes human, sensitized by an allergen. The term “allergen” means any substance that can induce the IgE production and an allergic reaction. Clinical examples are pollen, a acarid, house dust, albumin, milk, a soybean etc. and experimental examples are ovalbumin, bovine gamma globulin, bovine serum albumin, an antigen protein of cedar pollen (Cryj I and Cryj II), an antigen protein for acarid (Derf I and Derf II) etc. The term “a dosage that the suppressor does not suppress or weakly suppresses the IgM, IgG and/or IgA production” means the dosage at which the suppression rate of the IgG, IgM and/or IgA is 10% or less, preferably 5% or less, more preferably 3% or less as compared with those produced without administration of the selective suppressor of the IgE production of the present invention.
The selective suppressor of the IgE production of the present invention suppresses infiltration of an inflammatory cell to a tissue. The term “inflammatory cell” includes all of a lymphocyte, an eosinophil, a neutrophile and a macrophage, and an eosinophil and/or a neutrophile are preferable.
The effect of the selective suppressor on the IgE production of the present invention is potent for its direct action to B cells. Because the suppressor does not affect the humoral immunity concerning a biological protective reaction, it has many advantages, for example, little side effect such as infections etc.,
All of compounds that have the above effect are useful as an immunosuppressor regardless of the structure and one of the examples is the compound (I) or (I′′) of the present invention.
The compounds of the present invention also include ones which have the suppressive effect on a mitogen reaction and/or a cytokine reaction.
Specifically, the compounds have a potent antiproliferative effect on T and/or B cells and/or a suppressive effect on the IL-5 and/or IL-4 production. They selectively suppress the IL-4 and/or IL-5 production and do not suppress the IL-2 production.
The immunosuppressor or anti-allergic agent of the present invention is useful for prevention or a treatment of allergic diseases such as a rejection symptom against a transplantation of an organ or a tissue, a graft-versus-host reaction which is caused by a bone marrow transplantation, atopic allergic diseases (for example, a bronchial asthma, an allergic rhinitis, an allergic dermatitis and the like), a hypereosinophils syndrome, an allergic conjunctivitis, a systemic lupus erythematosus, a polymyositis, a dermatomyositis, a scleriasis, MCTD, a chronic rheumatoid arthritis, an inflammatory bowel disease, an injury caused by ischemia-reperfusion, a pollenosis, an allergic rhinitis, an urticaria, a psoriasis and the like.
When the compound of the present invention is administered as a immunosuppressor and/or anti-allergic agent, it can safely be administered both orally and parenterally. In the case of an oral administration, it may be in any usual forms such as tablets, granules, powders, capsules, pills, solutions, suspensions, syrups, buccal tablets, sublingual tablets and the like for the administration. When the compound is parenterally administered, any usual forms are preferable, for example, injections such as intravenous injections and intramuscular injections, suppositories, endermic agents, vapors and the like. An oral administration is particularly preferable.
A pharmaceutical composition may be manufactured by mixing an effective amount of the compound of the present invention with various pharmaceutical ingredients suitable for the administration form, such as excipients, binders, moistening agents, disintegrators, lubricants, diluents and the like. When the composition is of an injection, an active ingredient can be sterilized with a suitable carrier to give a pharmaceutical composition.
Specifically, examples of the excipients include lactose, saccharose, glucose, starch, calcium carbonate, crystalline cellulose and the like, examples of the binders include methylcellulose, carboxymethylcellulose, hydroxypropylcellulose, gelatin, polyvinylpyrrolidone and the like, examples of the disintegrators include carboxymethylcellulose, sodium carboxymethylcellulose, starch, sodium alginate, agar, sodium lauryl sulfate and the like, and examples of the lubricants include talc, magnesium stearate, macrogol and the like. Cacao oil, macrogol, methyl cellulose and the like may be used as base materials of suppositories. When the composition is manufactured as solutions, emulsified injections or suspended injections, dissolving accelerators, suspending agents, emulsifiers, stabilizers, preservatives, isotonic agents and the like may be added. For an oral administration, sweetening agents, flavors and the like may be added.
Although a dosage of the compound of the present invention as an immunosuppressor and/or anti-allergic agent should be determined in consideration of the patient's age and body weight, the type and degree of diseases, the administration route or the like, a usual oral dosage for human adults is 0.05–100 mg/kg/day and the preferable dosage is 0.1–10 mg/kg/day. In the case that it is parenterally administered, although the dosage highly varies with administration routes, a usual dosage is 0.005–10 mg/kg/day, preferably, 0.01–1 mg/kg/day. The dosage may be administered in one or some separate administrations.
The present invention is further explained by the following Examples and Experiments, which are not intended to limit the scope of the present invention.
EXAMPLE
The abbreviations which are used in EXAMPLE mean the following.
















Bn
benzyl



DME
1,2-dimethoxyethane



DMF
N,N-dimethylformamide



DMSO
dimethylsulfoxide



MCPBA
m-chloroperbenzoic acid



MOM
methoxymethyl



Ms
methanesulfonyl



Py
pyridyl



TBS
tert-butyldimethylsilyl



Tf
trifluoromethanesulfonyl



Ts
p-toluenesulfonyl










Example 1
Synthesis of the compounds (I-1) (I-2) and (I-3)




(Step 1) Synthesis of the Compound 1

To 300 ml of a solution of 10.63 g (22.08 mmol) of a compound (III-1) in 1,2-dimethoxyethane was added 3.60 g (3.12 mmol) of tetrakis(triphenylphosphine)palladium (0) at room temperature. To the mixture were added 80 ml of a solution of a compound 2 (9.50 g; 26.5 mmol) in 99% ethanol and 125 ml (250 mmol) of an aqueous solution of 2 M sodium carbonate and the reacted suspension was heated under refluxing in an argon atmosphere for 6 hours. After cooling, the reaction mixture was filtered off to remove an insoluble material and the filtrate was acidified with 2 N hydrochloric acid and extracted with ethyl acetate. The extract was washed with 5% aqueous solution of sodium bicarbonate and saturated brine successively, then dried and concentrated. After the residue was purified by silica gel chromatography (hexane-ethyl acetate 1:1), the obtained product was recrystallized from hexane-ethyl acetate to give the compound 1 (11.57 g; 87% yield) as colorless crystals.
(Step 2) Synthesis of the Compound (I-2)
To 60 ml of a suspension of the compound 1 (9.30 g; 15.48 mmol) in anhydrous dichloromethane was added 3.24 ml (23.22 mmol) of triethylamine, followed by addition of 1.80 ml (23.22 mmol) of methanesulfonyl chloride under ice-cooling and stirred for 2 hours at the same temperature. After the solvent was removed, the residue was acidified with 80 ml of 1 N hydrochloric acid and extracted with chloroform. The extract was washed with 1 N hydrochloric acid, 5% aqueous solution of sodium bicarbonate and saturated brine successively, and the obtained product was dried and concentrated. The obtained residue was recrystallized from hexane-ethyl acetate to give 9.93 g of the compound (I-2) (95% yield) as colorless crystals.
(Step 3) Synthesis of the Compound 3
Stirred were 300 ml of a solution of 9.76 g (14.38 mmol) of the compound (I-2) and 765 mg (4.31 mmol) of palladium chloride (II) in 1,4-dioxane under a hydrogen atmosphere at room temperature for 15 hours. An insoluble material was removed off by filtration with celite and the obtained filtrate was concentrated. The residue was recrystallized from hexane-ethyl acetate to give the compound 3 (8.43 g; 100% yield) as colorless crystals.
(Step 4) Synthesis of the Compound (I-3)
To 40 ml of a solution of the compound 3 (4.01 g; 6.81 mmol) in anhydrous N,N-dimethylformamide were added successive, 1.45 g (10.5 mmol) of potassium carbonate and 1.21 ml (10.5 mmol) of prenyl bromide. After the mixture was stirred under a nitrogen atmosphere for 15 hours at room temperature, the reaction mixture was poured into 230 ml of 6% aqueous citric acid and extracted with ethyl acetate. The extract was washed with 5% citric acid, 5% aqueous solution of sodium bicarbonate and saturated brine successively, followed by being dried and concentrated. The residue was recrystallized from hexane-ethyl acetate to give 4.01 g of the compound (I-3) (90% yield) as colorless crystals.
(Step 5) Synthesis of the Compound (I-1)
To 38 ml of a solution of 3.80 g (5.79 mmol) of the compound (I-3) in dimethylsulfoxide was added 15 ml (60.0 mmol) of 4 N sodium hydroxide and the reaction mixture was warmed at 60° C. for 4 hours. After the mixture was cooled, 100 ml of 1 N hydrochloric acid was added to it and the obtained mixture was extracted with ethyl acetate. The extract was washed with 5% aqueous solution of sodium bicarbonate and saturated brine successively, then dried and concentrated. The residue was recrystallized from methanol to give 1.72 g of the compound (I-1) (70% yield) as colorless crystals.
Reference Example 1
Synthesis of the Compound 2




To a solution of the compound 4 (80.0 g; 0.287 mol) in 300 ml of N,N-dimethylformamide were added tert-butyldimethylsilyl chloride (45.87 g; 0.296 mol) and imidazole (21.46 g; 0.315 mol) and stirred at room temperature for 19 hours. The reaction mixture was poured into 1 L of water and extracted with ether. The extract was washed with water and saturated brine successively and then dried and concentrated. The residue was purified by silica gel chromatography (hexane-ethyl acetate 50:1) to give the compound 5 (97.20 g; 86% yield) as a colorless oil.
To 850 ml of a solution of the compound 5 (97.20 g; 0.247 mol) in annydrous tetrahydrofuran was added 152 ml (0.252 mol) of a solution of 1.66 N n-butyllithium in hexane under a nitrogen atmosphere at −70° C. and stirred at the same temperature for 1.5 hours. To the mixture was added 171 ml (0.741 mol) of triisopropyl borate at −70° C. and stirred for 3 hours with gradually warming to room temperature. Under cooling with ice, 500 ml of water and 320 ml of 5% citric acid were added to the mixture and stirred at the same temperature for 30 minutes. The solution was extracted with ethyl acetate and the extract was washed with water and saturated brine successively, then dried and concentrated. The residue was purified by silica gel chromatography (hexane-ethyl acetate 2:1) to give the compound 2 (51.10 g; 58% yield) as colorless crystals.
Reference Example 2
Synthesis of the Compound (III-1)




(Step 1) Synthesis of the Compound 8

To a solution of 15.30 g (62.4 mmol) of a compound 7 (Journal of Chemical Society, 1925, 1998) in 300 ml of 1,2-dimethoxyethane was added 3.60 g (3.12 mmol) of tetrakis(triphenylphosphine)palladium (0) at room temperature. To the mixture were added a solution of 18.89 g (74.9 mmol) of a compound 6 (GB-A No. 2276162) in 80 ml of 99% ethanol and 125 ml (250 mmol) of an aqueous solution of 2 M sodium carbonate and the reaction suspension was heated under refluxing in an argon atmosphere for 6 hours. After cooling, the reaction mixture was filtered off to remove an insoluble substance. The filtrate was acidified with 2 N hydrochloric acid and extracted with ethyl acetate. The extract was washed with 5% aqueous solution of sodium bicarbonate and saturated brine successively, then dried and concentrated. The residue was purified by silica gel chromatography (hexane-ethylacetate 1:1) and recrystallized from hexane-ethyl acetate to give the compound 8 (15.68 g; 97% yield) as colorless crystals.
(Step 2) Synthesis of the Compound 9
To a suspension of the compound 8 (15.34 g; 59.39 mmol) in 240 ml of anhydrous dichloromethane were added 16.6 ml (118.8 mmol) of triethylamine and 6.93 ml (89.09 mmol) of methanesulfonyl chloride under ice-cooling and stirred at the same temperature for 2 hours. After the solvent was removed, the residue was acidified with 1 N hydrochloric acid (100 ml) and extracted with ethyl acetate. The extract was washed with 1 N hydrochloric acid, 5% aqueous solution of sodium bicarbonate and saturated brine successively, then dried and concentrated. The residue was recrystallized from hexane-ethyl acetate to give the compound 9 (17.24 g; 86% yield) as colorless crystals.
(Step 3) Synthesis of the Compound (III-24)
To 210 ml of a suspension of the compound 9 (17.03 g; 50.63 mmol) in acetic acid were added 6.23 g (75.95 mmol) of sodium acetate and 3.91 ml (75.95 mmol) of bromine at room temperature and stirred at the same temperature for 16 hours. After 3.91 ml (75.95 mmol) of bromine was added to the reacted suspension and stirred at 50° C. for 4 hours, 3.91 ml (75.95 mmol) of bromine was added and stirred at 50° C. for 3 hours. The reaction mixture was poured into 1 L of 1 M aqueous sodium thiosulfate and stirred for 30 minutes. The precipitate was collected by filtration and washed with water. The obtained crystals were dissolved in 800 ml of chloroform, washed with 5% aqueous solution of sodium bicarbonate and saturated brine successively, then dried and concentrated. The residue was recrystallized from hexane-ethyl acetate to give the compound (III-24) (18.12 g; 86% yield) as colorless crystals.
(Step 4) Synthesis of the Compound 10
To a suspension of the compound (III-24) (15.80 g; 38.05 mmol) in 400 ml of 1,2-dichloroethane was added 12.30 g (57.05 mmol) of 80% m-chloroperoxybenzoic acid at room temperature and stirred at the same temperature for 17 hours. The reaction mixture was poured into 360 ml of 0.2 M aqueous sodium thiosulfate and extracted with chloroform. The extract was washed with 300 ml of 0.2 M sodium thiosulfate and 200 ml of 5% of sodium bicarbonate (×2) successively, then dried and concentrated. The residue (15.80 g) was dissolved in 330 ml of 1,2-dimethoxyethane and 30 ml (120 mmol) of 4 N hydrochloric acid was added. After the reaction mixture was stirred at 50° C. for 12 hours and cooled, the solvent was removed and the residue was extracted with ethyl acetate. The extract was washed with 5% aqueous solution of sodium bicarbonate and saturated brine successively, then dried and concentrated to give the compound 10 (14.35 g; 97% yield) as pale brown crystals.
(Step 5) Synthesis of the Compound (III-1)
Using an analogous procedure for the compound (I-4), 12.63 g of the compound (III-1) as colorless crystals (88% yield) was obtained from the compound 10 (12.0 g; 29.76 mmol).
Example 2
Synthesis of the Compound (I-4)




(Step 1) Synthesis of the Compound 11

To a solution of 816 mg (2 mmol) of a compound (III-2) in 40 ml of 1,4-dioxane were added 114 mg (0.1 mmol) of tetrakis(triphenylphosphine)palladium (0), 748 mg (2.09 mmol) of the compound 2 and 589 mg (2.77 mmol) of powders of anhydrous potassium phosphate at room temperature and heated in a nitrogen atmosphere at 85° C. for 23 hours. The reaction mixture was cooled and extracted with ethyl acetate. The extract was washed with 2 N hydrochloric acid, 5% aqueous sodium bicarbonate and saturated brine successively, then dried and concentrated. The residue was purified by silica gel chromatography (hexane-ethyl acetate 4:1) and crystallized from pentane to give the compound 11 (745 mg; 67% yield) as pale yellow crystals.
(Step 2) Synthesis of the Compound (I-4)
To a solution of the compound 11 (557 mg; 1 mmol) in 10 ml of dichloromethane was added 259 mg (1.2 mmol) of 80% m-chloroperbenzoic acid at room temperature and stirred for 15 hours. The reaction mixture was poured into 0.1 M aqueous sodium thiosulfate and extracted with ethyl acetate. The extract was washed with 0.1 M aqueous sodium thiosulfate, 5% aqueous sodium bicarbonate and saturated brine successively, then dried and concentrated. To a solution of 650 mg of the obtained residue in 5 ml of methanol was added a solution of 1 M sodium methoxide in 2 ml of methanol under ice-cooling and stirred for 30 minutes. After the reacted solution was acidified with 2 N hydrochloric acid and extracted with ethyl acetate, the extract was washed with saturated brine, then dried and concentrated. To a solution of 647 mg of the obtained residue in 10 ml of tetrahydrofuran was added 2 ml of 1 M tetrabutylammonium fluoride in tetrahydrofuran under ice-cooling and stirred for 30 minutes. The obtained reaction mixture was poured into 2 N aqueous hydrochloric acid under ice-cooling to acidify and extracted with ethyl acetate. The ethyl acetate layer was washed with water, 5% aqueous sodium bicarbonate and saturated brine successively, then dried and concentrated. The residue was purified by silica gel chromatography (hexane-ethyl acetate 2:1) to give 275 mg of the compound (I-4) (62% yield) as powders.
Reference Example 3
Synthesis of the Compound (III-2)




(Step 1) Synthesis of the Compound 13

To 26 ml of a solution of 2.61 g (10 mmol) of a compound 12 (Journal of Organic Chemistry, 1987, 52, 4485) in dimethylformamide were added 400 mg (10 mmol) of 60% sodium hydride dispersion in oil and 836 mg (11 mmol) of chloromethyl methyl ether under ice-cooling and stirred for 30 minutes. After warming to room temperature, it was further stirred for 1 hours. The reaction mixture was concentrated under reduced pressure and extracted with ethyl acetate. The extract was washed with 5% aqueous solution of sodium bicarbonate and saturated brine successively, then dried and concentrated. The residue was recrystallized from ethyl acetate-hexane-pentane to give the compound 13 (2.8 g; 92% yield).
(Step 2) Synthesis of the Compound 14
Using an analogous procedure for the compound 8, the compound 14 was obtained as a pale yellow oil (96% yield) from the compound 13 and the compound 15 (Tokyo Kasei Kogyo Co., Ltd.)
(Step 3) Synthesis of the Compound 16
To 16 ml of a suspension of 1.38 g (4.3 mmol) of the compound 14 in methanol was added 4 ml of 2 N aqueous hydrochloric acid and stirred for 1 hour under warming at 60° C. The reaction mixture was concentrated under reduced pressure and extracted with ethyl acetate. The extract was washed with 5% aqueous sodium bicarbonate and saturated brine successively, then dried and concentrated to give the compound 16 (1.12 g; 94% yield) as a yellow crystalline residue.
(Step 4) Synthesis of the Compound (III-2)
To 12 ml of a solution of the compound 16 (1.12 g; 4.05 mmol) in anhydrous dichloromethane was added 1.02 ml (6.08 mmol) of trifluoromethanesulfonic anhydride and then 980 ml (12.2 mmol) of pyridine under ice-cooling and stirred for 30 minutes. The reaction mixture was allowed to warm to room temperature and stirred for additional 2 hours and the solvent was removed. The residue was extracted with ethyl acetate, washed with 5% aqueous sodium bicarbonate and saturated brine successively, then dried and concentrated. The obtained crude product was purified by silica gel chromatography to give 1.23 g of the compound (III-2) (74% yield) as a white crystalline residue.
Example 3
Synthesis of the Compounds (I-5), (I-6) and (I-7)




(Step 1) Synthesis of the Compound (I-5)

Using an analogous procedure for the compound 1 in Example 1, 634 mg (0.972 mmol) of the compound (I-5) was synthesized from 881 mg (1.50 mmol) of the compound (III-11) and 370 mg (1.95 mmol) of 3-trifluoromethyl boric acid. 65% yield.
(Step 2) Synthesis of the Compound 18
Using an analogous procedure for the compound 3 in Example 1, the compound 18 (360 mg; 0.640 mmol) was synthesized from 433 mg (0.664 mmol) of the compound (I-5). 96% yield.
(Step 3) Synthesis of the Compound (I-6)
Using an analogous procedure for the compound (I-3) in Example 1, 185 mg (0.293 mmol) of the compound (I-6) was synthesized from the compound 18 (170 mg; 0.302 mmol). 97% yield.
(Step 4) Synthesis of the Compound (I-7)
Using an analogous procedure for the compound (I-1) in Example 1, 85 mg (0.179 mmol) of the compound (I-7) was synthesized from 150 mg (0.238 mmol) of the compound (I-6). 75% yield.
Reference Example 4
Synthesis of the Compound (III-11)




(Step 1) Synthesis of the Compound 19

Using an analogous procedure for the compound 10 in Reference Example 2, the compound 19 (24.04 g; 103 mmol) was synthesized from the compound 7 (40.03 g; 163 mmol). 63% yield.
(Step 2) Synthesis of the Compound 20
To a solution of tert-butylamine (5.0 ml; 47.8 mmol) in 10 ml of toluene was added iodine (5.94 g; 23.39 mmol) under a nitrogen atmosphere and stirred for 50 minutes at room temperature. The compound 19 (5.46 g; 23.43 mmol) was added to the solution under ice-cooling, then warmed to room temperature and stirred for 6 days. The reaction mixture was poured into 1 M of aqueous sodium thiosulfate and extracted with ethyl acetate. The extract was washed with 1 M aqueous sodium thiosulfate and saturated brine successively, then dried and concentrated to give the compound 20 (8.30 g; 23.16 mmol). 99% yield.
(Step 3) Synthesis of the Compound 21
Using an analogous procedure for the compound 1 in Example 1, the compound 21 (2.10 g; 4.87 mmol) was synthesized from the compound 20 (8.70 g; 24.20 mmol). 20% yield.
(Step 4) Synthesis of the Compound (III-11)
Using an analogous procedure for the compound (I-2) in Example 1, 2.61 g (4.44 mmol) of the compound (III-11) was synthesized from the compound 21 (3.20 g; 7.42 mmol). 60% yield.
Example 4
Synthesis of the compound (I-9)




(Step 1) Synthesis of the Compound 22

Using an analogous procedure described in Reference Example 1, 1.53 g (3.63 mmol) of the compound (I-1) was silylated and the obtained crude product was crystallized from methanol to obtain the compound 22 (2.62 g; 95% yield) as colorless crystals.
(Step 2) Synthesis of the Compound 23
To a solution of the compound 22 (2.38 g; 3.1 mmol) in 90 ml of acetone were added 415 mg (3.74 mmol) of trimethylamine-N-oxide dihydrate and 1.60 ml of 5% aqueous solution of osmium tetroxide (0.3 mmol) and stirred for 1 hour at room temperature. After 20 ml of water was added to the reaction mixture, 4.0 g of sodium bicarbonate and 4.0 g of sodium bisulfite were added and stirred for 30 minutes. The reaction mixture was concentrated under reduced pressure and the residue was extracted with ethyl acetate. The extract was washed with saturated brine, then dried and concentrated.
A solution of 1.96 g (9.16 mmol) of sodium periodate in 33 ml of water was added dropwise to a solution of 2.46 g of the residue obtained by the above method in 90 ml of ethanol with stirring at room temperature. After stirring for 2 hours, 100 ml of water was added to the reaction mixture and the precipitate was collected by filtration and dried to give the compound 23 (1.98 g; 87% yield) as powder.
(Step 3) Synthesis of the Compound (I-9)
To a suspension of 146 mg (0.38 mmol) of n-propyltriphenylphosphonium bromide in 2.5 ml of anhydrous tetrahydrofuran was added 32 mg (0.29 mmol) of potassium tert-butoxide in a nitrogen atmosphere at 0° C. and stirred at the same temperature for 1 hour. The reaction mixture was cooled to −78° C., a solution of the compound 23 (70 mg; 0.095 mmol) in 1.5 ml of anhydrous tetrahydrofuran was added and stirred for 30 minutes at the same temperature and for additional 1 hour at room temperature. The reaction mixture was poured into an ice-cooling aqueous solution of saturated ammonium chloride and extracted with ethyl acetate. The extract was washed with saturated brine, then dried and concentrated.
Using an analogous procedure described in Example 2 Step 2, 70 mg of the residue obtained by the above method was desilylated and the obtained crude product was purified by silica gel chromatography (toluene-ethyl acetate 4:1) to give 37 mg of the compound (I-9) as pale yellow crystals.
Example 5
Synthesis of the compound (I-565)




(Step 1) Synthesis of the Compound (I-563)

Using an analogous procedure for the compound 2 in Example 1, 850 mg of the compound (I-563) was obtained from a compound (III-27) (800 mg; 1.59 mmol) and the compound 2 (1.25 g; 3.50 mmol) as colorless crystals (86% yield).
(Step 2) Synthesis of the Compound (I-565)
To a solution of 120 mg (0.193 mmol) of the compound (I-563) in 3 ml dimethoxyethane and 1 ml of ethyl acetate was added 2.4 ml of 4 N hydrochloric acid at 40° C. and stirred at the same temperature for 2 hours 20 minutes. After cooling, the reaction mixture was neutralized with aqueous solution of saturated sodium bicarbonate and extracted with ethyl acetate. The extract was washed with saturated aqueous solution of sodium bicarbonate and saturate brine, then dried and concentrated. The obtained crude product was crystallized from hexane-ethyl acetate to give 93 mg of the compound (I-565) as pale yellow crystals (92% yield).
Reference Example 5
Synthesis of the Compound (III-27)




(Step 1) Synthesis of the Compound 24

In a mixture of 17.5 ml of tert-butanol and 5.3 ml of 2-methyl-2-butene was suspended 415 mg (1.00 mmol) of the compound (III-24), 6.7 ml of aqueous solution of 724 mg (8.00 mmol) of sodium chlorite and 968 mg (6.20 mmol) of sodium dihydrogen phosphate dihydrate was added and stirred at the same temperature for 4 hours 30 minutes. The solution of 1 M sodium thiosulfate was added to the reaction mixture and the mixture was extracted with ethyl acetate. Then, organic layer was extracted with aqueous solution of saturated sodium bicarbonate. Then the aqueous layer was acidified with conc. hydrochloric acid and extracted with ethyl acetate. The extract was washed with saturated brine, then dried and concentrated to give the compound 24 (384 mg; 89% yield) as colorless crystals.
(Step 2) Synthesis of the Compound (III-27)
To 10 ml of a suspension of the compound 24 (1.50 g; 3.48 mmol) in tert-butanol were added 0.533 ml (3.83 mmol) of triethylamine, followed by 0.825 ml (3.83 ml) of diphenyl phosphate azide, and the mixture was stirred at 100° C. for 23 hours. After the reaction mixture was cooled, water was added to it and the mixture was extracted with ethyl acetate. The extract was washed with saturated aqueous solution of sodium bicarbonate and saturated brine, then dried and concentrated. The residue was purified by silica gel chromatography (hexane-ethyl acetate 2.5:1) to give 1.43 g of the compound (III-27) as colorless form product (82% yield).
Example 6
Synthesis of the Compound (I-480)




To a solution of 120 mg of a compound which was eliminated a Boc group of the compound (I-479) in 2 ml of tetrahydrofuran and 0.5 ml of methanol were added 33 ml (0.34 mmol) of 3-methyl-2-butenal and 90 ml (0.26 mmol) of 3 M aqueous solution of sulfuric acid at 0° C. and stirred for 10 minutes. Further, 19.6 mg of sodium borohydride was added in small portions to the mixture and stirred at room temperature for 1 hour. The saturated aqueous solution of sodium bicarbonate was added to the reaction mixture and extracted with ethyl acetate. The extract was washed with saturated brine, then dried and concentrated. The residue was purified by silica gel chromatography (hexane-ethyl acetate 3:1) to give 98 mg of the compound (I-480) as colorless crystals (78% yield).
Example 7
Synthesis of the Compound (I-628)




Using an analogous procedure for the compound 1 in Example 1, 1.2 g (2 mmol) of the compound (III-44) was reacted with 551 mg (2.2 mmol) of 4-bromomethanesulfonyl anilide were reacted, followed by desilylated by an analogous procedure described in Example 1 Step 2. The obtained crude product was crystallized from ethyl acetatehexane to obtain 760 mg of the compound (I-628) as pale yellow crystals (73% yield).
Reference Example 6
Synthesis of the Compound (III-44)




(Step 1) Synthesis of the Compound 25

Using an analogous procedure for the compound 5 in Reference Example 1, a crude product was synthesized by the reaction of 22.2 g (52.7 mmol) of the compound 21, 8.95 g (132 mmol) of imidazole and 17.5 g (1.16 mmol) of tert-butyldimethylsilyl chloride. The obtained product was purified by silica gel chromatography (ethyl acetate:hexane=1:20) and crystallized from ethyl acetate-hexane to give 29.7 g of the compound 25 as colorless crystals (85% yield).
(Step 2) Synthesis of the Compound (III-44)
Using an analogous procedure for the compound 2 in Reference Example 1, 402.7 g (610 mmol) of the compound 25 was reacted with 678 ml (814 mmol) of 1.08 N s-butyl lithium in cyclohexane, followed by addition of 282 ml (1.22 mol) of triisopropyl borate to give 246 g of the compound (III-44) as colorless powders (65% yield):
Example 8
Synthesis of the compound (I-233)




In an argon atmosphere, 2.87 g (8.0 mmol) of the compound 20 was dissolved in 32 ml of dimethoxyethane and 8 ml of ethanol, 3.01 g of the compound 2 and 16 ml of 2 M aqueous solution of sodium carbonate were added and the reaction mixture was degassed. To the mixture was added 462 mg (0.4 mmol) of palladium tetrakistriphenylphosphine and the mixture was heated under refluxing for 2 hours. After the reaction mixture was cooled to room temperature, 2.02 g (12.0 mmol) of 4-methylthiophenyl boronic acid, 462 mg (0.4 mmol) of palladium tetrakistriphenylphosphine, 16 ml of 2 M aqueous solution of sodium carbonate, 32 ml of dimethoxyethane and 8 ml of ethanol were added to it. Then, the reaction mixture was, degassed again and heated under refluxing for 16 hours. After the reaction mixture was cooled to room temperature, 100 ml of 5% aqueous citric acid was added and stirred at the same temperature for 1 hour. Ethyl acetate was added to the reaction mixture and the organic layer was washed with 5% aqueous citric acid, water, saturated aqueous solution of sodium bicarbonate and saturated brine successively, then dried and concentrated. The residue was purified by silica gel chromatography (hexane-ethyl acetate 3:1) to obtain 2.13 g of crude crystals. The obtained crude crystals were recrystallized from hexane-ethyl acetate to give 1.66 g of the compound (I-233) as colorless crystals (44% yield)
Example 9
Synthesis of Other Compounds
Following compounds (I) were synthesized by analogous procedures described above. The structures and physical constants of the compounds (III) and (I) are as follows.



















































































































































































































































































































































































































































































































































































































































TABLE 1







III-1
m.p. 201–203° C.



1HNMR(DMSO-d6)δ 3.44(s, 3H), 3.48(s, 3H), 3.62(s, 3H),



3.92(s, 3H), 7.09(s, 1H), 7.40–7.53(m, 2H), 7.65–7.78(m, 2H)


III-2
1HNMR(CDCl3)δ 3.47(s, 3H), 3.94(s, 3H), 7.13–7.24(m, 3H),



7.50–7.59(m, 2H), 10.41(s, 1H)



IR(KBr)1700, 1562, 1479, 1438, 1393, 1226, 1199, 1180,



1161, 1076, 1047 cm−1


III-3
m.p. 181–182° C.



1HNMR(CDCl3)δ 3.21(s, 3H), 3.40(s, 3H), 3.49(s, 3H), 3.90(s,



3H), 4.81(s, 2H), 4.85(s, 2H), 6.86(s, 1H), 7.32–7.40(m, 2H),



7.60–7.68(m, 2H)



IR(KBr)1504, 1467, 1370, 1235, 1152, 1038, 1010, 870,



846, 785 cm−1


III-4
1HNMR(CDCl3)δ 2.95(s, 3H), 3.18(s, 3H), 3.21(s, 3H), 3.41(s,



3H), 3.91(s, 3H), 6.84(s, 1H), 7.37(d, J=8.9Hz, 2H), 7.63(d,



J=8.9Hz, 2H)


III-5
m.p. 140–141° C.



1HNMR(CDCl3)δ 3.21(s, 3H), 3.45(s, 3H), 3.48(s, 3H), 3.96(s,



3H), 7.40(d, J=8.9Hz, 2H), 7.54(d, J=8.9Hz, 2H)



IR(KBr)1446, 1426, 1409, 1370, 1362, 1184, 1153, 1029,



973, 920, 870, 849, 776 cm−1


III-6
Tokyo Kasei Kogyo Co., Ltd.


III-7
1HNMR(CDCl3)δ :3.51(s, 3H), 3.92(s, 3H), 6.05(s, 2H), 6.92(d,



J=8.1Hz, 1H), 7.02(d, J=8.1Hz, 1H), 7.07(s, 1H), 7.18



(s, 1H), 10.40(s, 1H)



IR(KBr)1691, 1600, 1577, 1474, 1447, 1422, 1388, 1352,



1252, 1237, 1227, 1201, 1134, 1124, 1082, 1038 cm−1


III-8
1HNMR(CDCl3)δ 3.20(s, 3H), 3.77(s, 3H), 3.90(s, 3H), 6.86(s,



1H), 6.98(s, 1H), 7.32–7.37(m, 2H), 7.51–7.56(m, 2H)


III-9
HNMR(CDCl3)δ 3.20(s, 3H), 3.34(s, 3H), 7.37–7.47(m, 3H),



7.53–7.63(m, 3H), 7.71(d, J=2.1Hz, 1H)


III-10
1HNMR(CDCl3)δ 3.76(s, 3H), 3.90(s, 3H), 6.85(s, 1H), 6.97(s,



1H), 7.08–7.15(m, 2H), 7.42–7.49(m, 2H)


III-11
oil



1HNMR(CDCl3)δ 2.72(s, 3H), 3.11(s, 3H), 3.75(s, 3H), 3.92(s,



3H), 5.17(s, 2H), 7.05–7.16(m, 2H), 7.24–7.50(m, 2H)

















TABLE 2







III-12
Oil



1HNMR(CDCl3)δ 3.51(s, 3H), 3.70(s, 3H), 3.86(s, 3H), 3.89(s,



3H), 5.28(s, 2H), 6.65(s, 1H), 6.97&7.47(ABq, J=8.6Hz, 4H)


III-13
m.p. 120–122° C. 1HNMR(CDCl3)δ 3.20(s, 3H), 3.53(s,



3H), 3.70(s, 3H), 3.89(s, 3H), 5.28(s, 2H), 6.63(s, 1H),



7.32–7.37(m, 2H), 7.56–7.61(m, 2H)



IR(KBr)1505, 1468, 1427, 1375, 1237, 1175, 1153, 1100,



1072, 1003, 972 cm−1


III-14
m.p. 146–147° C.



1HNMR(CDCl3)δ 3.85(s, 3H), 6.94–7.01(m, 2H), 7.38–7.56



(m, 6H) 



IR(KBr)1603, 1522, 1481, 1288, 1255, 1036 cm−1


III-15
1HNMR(CDCl3)δ 3.07(s, 6H), 3.49(s, 3H), 3.92(s, 3H), 6.95



(brs, 2H), 7.20(s, 1H), 7.51(d, J=8.7Hz, 2H), 10.42(s, 1H)


III-16
1HNMR(CDCl3)δ 3.48(s, 3H), 3.50(s, 3H), 3.92(s, 3H), 6.81



(s, 1H), 7.70(s, 4H)


III-17
1HNMR(CDCl3)δ 3.24(s, 3H), 3.49(s, 3H), 3.94(s, 3H), 7.21



(s, 1H), 7.42(d, J=8.4Hz, 2H), 7.65(d, J=8.4Hz, 2H),



10.41(s, 1H)


III-18
m.p. 88–89° C.



1HNMR(CDCl3)δ 2.20(s, 3H), 2.38(s, 3H), 3.19(s, 3H),



7.06(s, 1H), 7.33(s, 4H), 7.45(s, 1H)



IR(KBr)1479, 1366, 1195, 1173, 1151, 970, 865, 850, 796 cm−1


III-19
m.p 72–73° C.



1HNMR(CDCl3)δ 3.20(s, 3H), 7.20(dd, J=6.6, 8.4Hz, 1H),



7.35–7.44(m, 3H), 7.53–7.60(m, 2H)



IR(KBr)1514, 1481, 1364, 1335, 1182, 1144, 979,



870, 798 cm−1


III-20
m.p. 144–146° C.



1HNMR(CDCl3)δ 3.45(s, 3H), 3.89(s, 3H), 4.99(brs, 2H), 6.19



(s, 1H), 6.42(s, 1H), 6.88–6.94(m, 2H), 7.44–7.49(m, 2H)



IR(KBr)3471, 3392, 29863, 1612, 1596, 1461, 1410, 1223,



1175, 1099, 1079, 1011 cm−1

















TABLE 3







III-21
oil



1HNMR(CDCl3)δ 1.09(t, J=7.5Hz, 3H), 1.82–1.94(m, 2H),



3.58(s, 3H), 3.86(s, 3H), 4.06(t, J=6.6Hz, 2H), 6.63(s, 1H),



6.94–6.99(m, 2H), 7.44–7.49(m, 2H)



IR(film): 3100–2800(br), 1609, 1583, 1513, 1466, 1423, 1401,



1378, 1291, 1249, 1232, 1178, 1127, 1097, 1034, 1012 cm−1


III-22
m.p. 83.5–84.5° C.



1HNMR(CDCl3)δ 3.20(br, 1H), 3.54(s, 3H), 3.85–3.90(m,



2H), 3.86(s, 3H), 3.90(s, 3H), 4.29–4.32(m, 2H), 6.66(s, 1H),



6.95–7.00(m, 2H), 7.45–7.50(m, 2H)



IR(KBr)3600–2800(br), 1608, 1583, 1513, 1467, 1441, 1421,



1398, 1365, 1290, 1247, 1178, 1133, 1097, 1079,



1028, 1007 cm−1


III-23
m.p. 99–101° C.



1HNMR(CDCl3)δ 3.20(s, 3H), 3.39(s, 3H), 3.91(s, 3H), 3.99(s,



3H), 6.89(s, 1H), 7.37(d, J=8.7Hz, 2H), 7.64(d, J=8.7Hz, 2H)



IR(KBr)1747, 1466, 1367, 1348, 1153, 1059, 968, 859,



794 cm−1


III-24
1HNMR(CDCl3)δ 3.22(s, 3H), 3.45(s, 3H), 3.94(s, 3H),



7.04(s, 1H), 7.32–7.43(m, 2H), 7.58–7.69(m, 2H), 10.42(s, 1H)


III-25
1HNMR(CDCl3)δ 2.46(broad, 1H), 3.21(s, 3H), 3.43(s, 3H),



3.90(s, 3H), 4.94(s, 2H), 6.83(s, 1H), 7.42–7.51(m, 2H),



7.57–7.68(m, 2H)


III-26
m.p. 109–110° C.



1HNMR(CDCl3)δ 1.97(br, 1H), 3.21(t, J=6.6Hz, 2H), 3.86(s,



3H), 3.89(s, 3H), 3.90(t, J=6.9Hz, 2H), 6.76(s, 1H), 6.95–7.00



(m, 2H), 7.49–7.53(m, 2H)



IR(KBr)3600–2800(br), 1609, 1581, 1511, 1462, 1441, 1426,



1385, 1289, 1250, 1237, 1179, 1116, 1078, 1046, 1031,



1005 cm−1


III-27
foam



1HNMR(CDCl3)δ 1.52(s, 9H), 3.20(s, 3H), 3.41(s, 3H), 3.90(s,



3H), 6.16(s, 1H), 6.76(s, 1H), 7.35(d, J=8.7Hz, 2H), 7.61(d,



J=8.7Hz, 2H)



IR(KBr)3371, 1718, 1505, 1497, 1367, 1241, 1151, 872 cm−1

















TABLE 4







III-28
m.p. 167–170° C.



1HNMR(CDCl3)δ 2.73(s, 3H), 3.74(s, 3H), 3.92(s, 3H), 7.08–



7.17(m, 3H), 7.31–7.36(m, 2H)



IR(CHCl3)2934, 1593, 1560, 1512, 1477, 1436, 1411,



1372, 1157, 1107, 1076, 997, 958, 892, 839, 815 cm−1


III-29
m.p. 140–142° C.



1HNMR(CDCl3)δ 3.27(s, 3H), 3.79(s, 3H), 3.90(s, 3H), 6.86(s,



1H), 6.97(s, 1H), 7.29(ddd, J=8.4, 2.2, 0.9Hz, 1H), 7.39(dd, J=



11.0, 2.2Hz, 1H), 7.43(t, J=8.4Hz, 1H)



IR(KBr)1504, 1421, 1344, 1225, 1208, 916, 824 cm−1


III-30
1HNMR(CDCl3)δ 3.77(s, 3H), 3.91(s, 3H), 3.95(s, 3H), 6.87(s,



1H), 7.01(s, 1H), 7.56(d, J=8.1Hz, 2H), 8.09(d, J=8.1Hz, 2H)


III-31
1HNMR(CDCl3)δ 3.78(s, 3H), 3.91(s, 3H), 6.88(s, 1H), 6.97(s,



1H), 7.60(d, J=8.1Hz, 2H), 7.71(d, J=8.1Hz, 2H)


III-32
m.p. 147–148° C.



1HNMR(CDCl3)δ 3.79(s, 3H), 3.92(s, 3H), 6.89(s, 1H), 7.01(s,



1H), 7.64–7.69(m, 2H), 8.26–8.31(m, 2H)



IR(KBr)3600–2800(br), 1595, 1511, 1490, 1422, 1354, 1249,



1215, 1145, 1106, 1032 cm−1


III-33
1HNMR(CDCl3)δ 3.31(s, 3H), 3.53(s, 3H), 3.94(s, 3H), 7.19(s,



1H), 7.39(ddd, J=8.3, 2.3, 1.0Hz, 1H), 7.39(dd, J=10.3, 2.3Hz,



1H), 7.43(t, J=8.3Hz, 1H), 10.40(s, 1H)


III-34
1HNMR(CDCl3)δ 0.13(s, 6H), 0.97(s, 9H), 2.51(s, 3H), 3.73(s,



3H), 3.93(s, 3H), 5.09(s, 2H), 6.84–6.99(m, 2H), 6.89(s, 1H),



7.05(s, 1H), 7.29–7.48(m, 5H)


III-35
m.p. 124–128° C.



1HNMR(CDCl3)δ 2.62(s, 3H), 3.74(s, 3H), 3.91(s, 3H),



5.19(s, 2H), 7.00–7.18(m, 4H), 7.30–7.49(m, 5H)



IR(CHCl3)2930, 1607, 1517, 1480, 1369, 1148, 1118, 1082,



1025, 969, 872 cm−1

















TABLE 5







III-36
oil



1HNMR(CDCl3)δ 0.13(s, 6H), 0.96(s, 3H), 3.01(s, 3H), 3.69(s,



3H), 3.86(s, 3H), 4.81(s, 2H), 5.08(s, 2H), 6.88–6.94(m, 3H),



7.30–7.47(m, 5H)



IR(KBr)3023, 2932, 2858, 1579, 1512, 1471, 1381, 1264,



1120, 1083 cm−1


III-37
oil



1HNMR(CDCl3)δ 0.78(t, J=7.5Hz, 3H), 1.03–1.25(m, 2H),



1.38–1.47(m, 2H), 3.68–3.72(m, 2H), 3.70(s, 3H), 3.86(s, 6H),



5.15(s, 2H), 5.63(s, 1H), 6.81(dd, J=1.8, 8.4Hz, 1H), 6.86(s,



1H), 6.95–6.97(m, 2H), 7.36–7.40(m, 5H)



IR(CH3Cl): 3543, 3200–2800(br), 1587, 1511, 1465,



1412, 1376, 1285, 1248, 1118, 1081, 1031 cm−1


III-38
m.p. 104–105° C.



1HNMR(CDCl3)δ 3.11(s, 3H), 3.77(s, 3H), 3.90(s, 3H), 5.17(s,



2H), 6.84(s, 1H), 6.98(s, 1H), 7.11(d, J=8.7Hz, 1H), 7.37–7.48



(m, 6H), 7.51(d, J=2.4Hz, 1H)



IR(KBr)3600–2800(br), 1503, 1420, 1389, 1364, 1246, 1215,



1185, 1132, 1117, 1097, 1030 cm−1


III-39
m.p. 134–136° C.



1HNMR(CDCl3)δ 3.78(s, 3H), 3.91(s, 3H), 5.29(s, 2H), 6.86(s,



1H), 6.97(s, 1H), 7.17(d, J=8.7Hz, 1H), 7.31–7.51(m, 7H),



7.63(dd, J=2.4, 8.7Hz, 1H), 8.01(d, J=2.4Hz, 1H)



IR(KBr)3434, 1620, 1532, 1494, 1413, 1280, 1222, 1206,



1133, 1108, 1037 cm−1


III-40
m.p. 100–101° C.



1HNMR(CDCl3)δ 3.55(s, 3H), 3.77(s, 3H), 3.90(s, 3H), 5.26(s,



2H), 6.84(s, 1H), 6.97(s, 1H), 7.16–7.31(m, 3H)



IR(KBr)3600–2800(br), 1524, 1503, 1449, 1401, 1380, 1268,



1246, 1222, 1200, 1156, 1126, 1098, 1078, 1030 cm−1


III-41
m.p. 109–110° C.



1HNMR(CDCl3)δ 1.54(s, 9H), 3.76(s, 3H), 3.90(s, 3H), 6.75(br,



1H), 6.84(s, 1H), 6.97(s, 1H), 7.21–7.29(m, 2H), 8.13(t,



J=8.7Hz, 1H)



IR(KBr)3600–2800(br), 1720, 1593, 1531, 1509, 1427, 1393,



1245, 1223, 1214, 1201, 1162, 1137, 1105, 1029 cm−1

















TABLE 6







III-42
foam



1HNMR(CDCl3)δ 2.36(s, 3H), 3.74(s, 3H), 3.88(s, 3H),



6.69(dd, J=0.6, 3.6Hz, 1H), 6.85(s, 1H), 6.99(s, 1H), 7.24–



7.27(m, 2H), 7.23(dd, J=1.8, 8.7Hz, 1H), 7.60(d, J=3.6Hz, 1H),



7.64(d, J=1.2Hz, 1H), 7.80–7.83(m, 2H), 8.02(d, J=



8.4Hz, 1H)



IR(KBr)3600–2800(br), 1508, 1463, 1444, 1421, 1373, 1246,



1216, 1176, 1132, 1093, 1038 cm−1


III-43
foam



1HNMR(CDCl3)δ 3.14(s, 3H), 3.51(s, 3H), 3.93(s, 3H), 5.20(s,



2H), 7.17(d, J=8.4Hz, 1H), 7.20(s, 1H), 7.38(m, 6H), 7.59



(d, J=1.8Hz, 1H), 10.40(s, 1H)



IR(CHCl3)2941, 1703, 1613, 1603, 1580, 1513, 1475,



1426, 1372, 1295, 1264, 1169, 1137, 1112, 1088, 1044,



971, 954, 932, 838 cm−1


III-44
1HNMR(CDCl3)δ 0.20(s, 6H), 0.13(s, 6H), 0.77(s, 9H),



0.97(s, 9H), 3.73(s, 3H), 3.83(s, 3H), 5.08(s, 2H), 6.06(s, 2H),



6.86–6.96(m, 3H), 7.01(s, 1H), 7.30–7.49(m, 5H)


III-45
m.p. 106–108° C.



1HNMR(CDCl3)δ 3.21(s, 3H), 3.43(s, 3H), 3.94(s, 3H), 5.87(s,



1H), 7.39(d, J=9.0Hz, 2H), 7.55(d, J=9.0Hz, 2H)



IR(KBr)3410, 1460, 1422, 1362, 1146, 1037, 874,



915, 787 cm−1


III-46
m.p. 123–124° C.



1HNMR(CDCl3)δ 2.48(brs, 1H), 3.21(s, 3H), 3.43(s, 3H),



3.94(s, 3H), 4.93(brs, 2H), 6.83(s, 1H), 7.37(d, J=9.0Hz, 2H),



7.63(d, J=9.0Hz, 2H)



IR(KBr)3524, 1463, 1352, 1233, 1152, 1009, 979, 869 cm−1


III-47
m.p. 107–109° C.



1HNMR(CDCl3)δ 1.93(s, 6H), 2.45(s, 6H), 4.75(brs, 1H),



6.87–6.96(m, 4H)



IR(KBr)3367, 1612, 1509, 1433, 1214, 990, 824 cm−1

















TABLE 7







III-48
oil



1HNMR(CDCl3)δ 1.14(t, J=6.9Hz, 3H), 1.46(t, J=6.9Hz, 3H),



3.58(q, J=6.9Hz, 2H), 3.58(q, J=6.9Hz, 2H),



6.19(s, 1H), 6.41(s, 1H), 6.86–



6.92(m, 2H), 7.43–7.49(m, 2H)



IR(CHCl3)3688, 3594, 3502, 2982, 1612, 1517, 1172,



1080, 1026, 925 cm−1


III-49
1HNMR(CDCl3)δ 0.02(s, 6H), 0.12(s, 6H), 0.90(s, 9H), 0.93(s,



9H), 4.54(s, 2H), 4.76(s, 2H), 6.84–6.89(m, 2H), 7.16–7.22(m,



2H), 7.37(s, 1H), 7.69(s, 1H)


III-50
m.p. 173–175° C.



1HNMR(CDCl3)δ 3.21(s, 3H), 3.47(s, 3H), 3.89(s, 3H), 6.15



(s, 1H), 6.42(s, 1H), 7.24–7.37(m, 2H), 7.61–7.66(m, 2H)



IR(KBr)3408, 2934, 1604, 1480, 1360, 1146, 1089, 1004,



865, 709, 547 cm−1


III-51
m.p. 156–158° C.



1HNMR(CDCl3)δ 3.21(s, 3H), 3.39(s, 3H), 3.90(s, 3H), 6.05(s,



1H), 7.36–7.44(m, 4H)



IR(KBr)3410, 2938, 1505, 1457, 1413, 1337, 1194, 1143, 1084,



1014, 876, 826, 542, 519 cm−1


III-52
m.p. 181–183° C.



1HNMR(CDCl3)δ 3.19(s, 3H), 3.88(s, 3H), 4.21–4.24(m, 2H),



4.39–4.42(m, 2H), 6.49(s, 1H), 7.45(ABq, J=8.7Hz, 4H)



IR(KBr)3435, 1598, 1505, 1474, 1425, 1366, 1178, 1147,



1113 cm−1


III-53
m.p. 155–157° C.



1HNMR(CDCl3)δ −0.11–0.02(m, 2H), 0.33–0.44(m, 2H),



0.91(m, 1H), 3.20(s, 3H), 3.41(d, J=7.0Hz, 2H), 3.50(s, 3H),



3.92(s, 3H), 6.88(s, 1H), 7.51(ABq, J=8.6Hz, 4H)



IR(KBr)3434, 1505, 1472, 1416, 1386, 1371, 1357, 1242,



1179, 1149, 1084 cm−1


III-54
m.p. 105–107° C.



1HNMR(CDCl3)δ 3.20(s, 3H), 3.39(s, 3H), 3.89(s, 3H), 4.77(s,



2H), 6.40(s, 1H), 7.33–7.55(m, 5H)



IR(KBr)3411, 1592, 1572, 1507, 1482, 1467, 1437, 1360, 1339,



1232, 1204, 1175, 1148, 1125, 1092 cm−1

















TABLE 8







III-55
m.p. 138–140° C.



1HNMR(CDCl3)δ 1.14(t, J=7.0Hz, 3H), 3.59(q, J=7.0Hz, 2H),



3.88(s, 3H), 4.97(bs, 1H), 6.42(s, 1H), 6.86–6.94(m, 2H),



7.43–7.51(m, 2H)



IR(KBr)3384, 3291, 2978, 1614, 1593, 1576, 1519, 1484,



1469, 1455, 1436, 1417, 1366, 1306, 1285, 1257, 1203,



1171, 1127, 1094, 1029 cm−1


III-56
m.p. 162–164° C.



1HNMR(CDCl3)δ 2.77(s, 3H), 3.17(s, 3H), 3.75(s, 3H), 3.92(s,



3H), 7.10(s, 2H), 7.35–7.43(m, 4H)



IR(CHCl3)1594, 1561, 1507, 1478, 1464, 1374, 1331,



1178, 1149, 1109, 1080, 1000, 970, 894, 871, 844 cm−1


III-57
m.p. 95–97° C.



1HNMR(CDCl3)δ 2.35(s, 3H), 3.77(s, 3H), 6.84–6.87(m,



2H), 7.12(s, 1H), 7.13(s, 1H), 7.35–7.38(m, 2H)



IR(CHCl3)3596, 2959, 2939, 2840, 1611, 1563, 1517,



1489, 1464, 1438, 1384, 1367, 1329, 1295, 1258, 1173, 1102,



1049, 1035, 1001, 911, 891, 835 cm−1


III-58
m.p. 173–175° C.



1HNMR(CDCl3)δ 6.91–6.94(m, 2H), 7.31–7.34(m, 2H), 7.87(s,



1H), 8.09(s, 1H), 9.89(s, 1H), 10.28(s, 1H)



IR(CHCl3)3437, 1685, 1610, 1516, 1456, 1394, 1370,



1270, 1261, 1238, 1214, 1173, 1144, 1053, 1012, 939, 905,



829, 808, 557, 458 cm−1


III-59
m.p. 173–175° C.



1HNMR(CDCl3)δ 1.10(t, J=6.9Hz, 3H), 1.48(t, J=6.9Hz,



3H), 3.20(s, 3H), 3.47(s, 3H), 3.66(q, J=6.9Hz, 2H), 4.11(q, J=



6.9Hz, 2H), 6.79(s, 1H), 7.32–7.39(m, 2H), 7.60–7.66(m, 2H)



IR(CHCl3)1502, 1458, 1372, 1176, 1148, 1074,



1023, 967, 870 cm−1


III-60
1HNMR(CDCl3)δ 2.17(s, 3H), 2.39(s, 3H), 3.19(s, 3H),



5.80(s, 1H), 6.71(s, 1H), 7.33(s, 4H)

















TABLE 9







III-61
m.p. 107–108° C.



1HNMR(CDCl3)δ 3.21(s, 3H), 3.79(s, 3H), 4.04(s, 3H), 7.39(d,



J=8.9Hz, 2H), 7.57(d, J=8.9Hz, 2H), 7.68(s, 1H), 10.17(s, 1H)



IR(KBr)1704, 1422, 1358, 1224, 1148, 1090, 1026, 974,



876 cm−1


III-62
m.p. 121–122° C.



1HNMR(CDCl3)δ 3.45(s, 3H), 3.47(s, 3H), 3.93(s, 3H),



4.68(s, 2H), 4.77(s, 2H), 7.22(s, 1H), 7.49(d, J=8.1Hz, 2H),



7.56(d, J=8.1Hz, 2H), 10.42(s, 1H)



IR(KBr)1695, 1476, 1422, 1232, 1189, 1130, 104O, 860 cm−1


III-63
m.p. 113–115° C.



1HNMR(CDCl3)δ 2.18(s, 3H), 3.22(s, 3H), 3.89(s, 3H), 6.85



(s, 1H), 7.11(s, 1H), 7.36(s, 4H)



IR(KBr)1497, 1413, 1354, 1230, 1146, 1097, 976, 864 cm−1


III-64
1HNMR(CDCl3)δ 5.65(s, 1H), 7.18(s, 1H), 7.30–7.35(m, 2H),



7.46–7.50(m, 3H)


III-65
1HNMR(CDCl3)δ :1.30(d, J=7.2Hz, 6H), 2.96(quintet, J=7.2Hz,



1H), 3.82(s, 3H), 3.91(s, 3H), 5.92(brs, 2H), 6.91(s, 1H), 7.30



(d, J=8.1Hz, 2H), 7.44(s, 1H), 7.49(d, J=8.1Hz, 2H)


III-66
m.p. 118–122° C.



1HNMR(CDCl3)δ 3.80(s, 3H), 3.91(s, 3H), 5.88(s, 2H),



6.84–6.92(m, 3H), 7.39–7.47(m, 3H)



IR(KBr)3600–2800(br), 1606, 1517, 1492, 1461, 1415, 1397,



1330, 1265, 1205, 1171, 1052 cm−1


III-67
m.p. 227–230° C.



1HNMR(CDCl3)δ 0.25(s, 6H), 1.02(s, 9H), 2.33(s, 3H), 2.82



(s, 2H), 6.88–6.93(m, 2H), 7.16(s, 1H), 7.21–7.25(m, 3H),



8.11(s, 1H)



IR(KBr)3600–2800(br), 1608, 1514, 1393, 1346, 1267,



1167 cm−1


III-68
m.p. 134–137° C.



1HNMR(CDCl3)δ 3.00(s, 6H), 3.81(s, 3H), 3.91(s, 3H), 6.00(s,



2H), 6.77–6.82(m, 2H), 6.90(s, 1H), 7.41(s, 1H), 7.46–7.51



(m, 3H)



IR(KBr)3600–2800(br), 1601, 1528, 1494, 1466, 1439, 1399,



1362, 1321, 1198, 1166, 1118, 1051 cm−1

















TABLE 10







III-69
m.p. 144–148° C.



1HNMR(CDCl3)δ 2.38(s, 3H), 2.82(s, 3H), 3.01(s, 6H),



7.79–7.83(m, 2H), 7.18(s, 1H), 7.27–7.31(m, 2H), 8.11(s, 1H)



IR(KBr)3600–2800(br), 1612, 1523, 1443, 1389, 1328,



1271, 1160 cm−1


III-70
m.p. 122–126° C.



1HNMR(CDCl3)δ 0.10(s, 9H), 0.78(s, 6H), 2.96(s, 6H), 3.75(s,



3H), 3.84(s, 3H), 6.08(s, 2H), 6.72–6.78(m, 2H), 7.01(s,



1H), 7.22–7.29(m, 2H)



IR(KBr)3600–2800(br), 1613, 1528, 1463, 1416, 1402,



1360, 1345, 1251, 1218, 1195, 1136, 1092, 1062, 991 cm−1


III-71
1HNMR(CDCl3)δ 2.21(s, 3H), 2.37(s, 3H), 3.89(s, 3H), 5.19



(s, 2H), 6.75(d.d, J=8.4&2.1Hz, 1H), 6.81(d, J=2.1Hz,



1H), 6.92(d, J=8.4Hz, 1H), 7.08(s, 1H), 7.30–7.50(m, 6H)


III-72
oil



1HNMR(CDCl3)δ 2.51(s, 6H), 2.75(s, 6H), 5.15(s, 2H), 5.67(s,



1H), 6.94(s, 1H), 6.96(d, J=8.4Hz, 1H), 7.04(dd, J=2.1, 8.4Hz,



1H), 7.18(s, 1H), 7.20(d, J=2.1Hz, 1H), 7.37–7.47(m, 5H)



IR(CHCl3)3032, 3428, 3000–280O(br), 1730, 1611,



1525, 1489, 1455, 1256, 1171, 1137, 1100 1036 cm−1


III-73
1HNMR(CDCl3)δ 2.21(s, 3H), 2.37(s, 3H), 5.15(s, 2H),



5.69(br, 1H), 6.73(dd, J=8.4, 1.8Hz, 1H), 6.89–6.99(m, 2H),



7.07(s, 1H), 7.26–7.46(m, 6H)


III-74
1HNMR(CDCl3)δ 1.09(t, J=7.2Hz, 3H), 1.22(t, J=7.5Hz,



3H), 2.55(q, J=7.2Hz,2H), 2.72(q, J=7.5Hz, 2H), 5.15(s,



2H), 5.70(s, 1H), 6.73(dd, J=8.4, 1.8Hz, 1H), 6.89(d, J=1.8Hz,



1H), 6.95(d, J=8.4Hz 1H), 7.04(s, 1H), 7.38–7.47(m, 6H)



IR(CHCl3)3542, 2970, 2933, 1586, 1508, 1480, 1384, 1324,



1290, 1160, 1127, 1064, 1011, 930, 898, 879, 857 cm−1


III-75
1HNMR(CDCl3)δ 2.04(s, 3H), 3.70(s, 3H), 3.90(s, 3H),



5.19(s, 2H), 5.50(m, 1H), 6.73(dd, J=2.1Hz, 1H), 6.97–7.00



(m, 2H), 7.29–7.48(m, 5H)

















TABLE 11







III-76
1HNMR(CDCl3)δ 2.04(s, 3H), 3.90(s, 3H), 5.15(s, 2H), 5.49(s,



1H), 5.74(s, 1H), 6.71(dd, J=8.1, 2.1Hz, 1H), 6.85(d, J=2.1Hz,



1H), 6.99–7.03(m, 2H), 7.39–7.45(m, 5H)



IR(CHCl3)3529, 2963, 2940, 1731, 1587, 1566, 1510,



1480, 1455, 1412, 1382, 1323, 1290, 1248, 1128, 1099, 1009,



935, 879 cm−1


III-77
m.p. 87–89° C.



1HNMR(CDCl3)δ 2.20(s, 3H), 2.37(s, 3H), 5.18(s, 2H), 6.90–



7.10(m, 4H), 7.30–7.51(m, 6H)



IR(CHCl3)1510, 1482, 1381, 1298, 1267, 1233, 1127,



1008, 952, 875, 812 cm−1


III-78
1HNMR(CDCl3)δ 1.25(d, J=6.9Hz, 6H), 2.24(s, 3H),



3.26(sept, J=6.9Hz, 1H), 5.20(s, 2H), 6.95(ddd, J=8.3, 2.2,



1.2Hz, 1H), 7.06(t, J=8.3Hz, 1H), 7.06(dd, J=11.9, 2.2Hz, 1H),



7.10(s, 1H), 7.17(s, 1H), 7.32–7.51(m, 5H)



IR(KBr)1492, 1420, 1228, 1203, 1140, 1012, 989, 841 cm−1


III-79
1HNMR(CDCl3)δ 2.43(s, 3H), 5.19(s, 2H), 7.06(t, J=



8.9Hz, 1H), 7.18–7.48(m, 10H)



IR(KBr)1491, 1437, 1214, 1135, 890, 810, 748 cm−1


III-80
m.p. 77–79° C.



1HNMR(CDCl3)δ 3.921(s, 3H), 5.21(s, 2H), 6.90–6.99(m, 3H),



7.31–7.50(m, 7H)



IR(KBr)3600–2800(br), 1518, 1477, 1418, 1237, 1212,



1167, 1140 cm−1


III-81
m.p. 103–105° C.



1HNMR(CDCl3)δ 2.16(s, 3H), 2.37(s, 3H), 2.42(s, 3H), 3.16(m,



3H), 5.21(s, 2H), 7.16–7.17(m, 3H), 7.24–7.27(m, 1H),



7.36–7.48(m, 5H)



IR(CHCl3)2940, 1613, 1514, 1478, 1455, 1423, 1366,



1331, 1292, 1264, 1176, 1140, 1126, 1096, 1045, 1009, 972,



955, 920, 843 cm−1


III-82
1HNMR(CDCl3)δ 2.19(s, 3H), 3.88(s, 3H), 5.20(s, 2H), 6.84(s,



1H), 6.95(m, 1H), 7.03–7.05(m, 3H), 7.35–7.49(m, 5H)


III-83
m.p. 83–85° C.



1HNMR(CDCl3)δ 2.19(s, 3H), 3.88(s, 3H), 3.91(s, 3H), 5.21(s,



3H), 6.76(dd, J=8.4, 2.1Hz, 1H), 6.82(d, J=2.1Hz, 1H),



6.87(s, 1H), 6.93(d, J=8.4Hz, 1H), 7.08(s, 1H), 7.32–



7.50(m, 5H)



IR(CHCl3)2962, 2937, 1613, 1579, 1499, 1464, 1455,



1443, 1421, 1319, 1249, 1170, 1140, 1103, 1029, 1008,



989, 901, 832 cm−1

















TABLE 12







III-84
oil



1HNMR(CDCl3)δ 1.44(d, J=6.9Hz, 3H), 2.19(s, 3H), 4.09(q,



J=6.9Hz, 2H), 5.20(s, 2H), 6.82(s, 1H), 6.94–7.08(m, 3H),



7.32–7.49(m, 6H)



IR(CHCl3)3597, 2928, 1731, 1609, 1523, 1494, 1476,



1387, 1298, 1261, 1173, 1127, 1048, 834 cm−1


III-85
1HNMR(CDCl3)δ 2.26(s, 3H), 2.52(s, 3H), 3.90(s, 3H), 4.59



(brs, 2H), 5.20(s, 2H), 6.73–7.10(m, 4H), 7.27–7.52(m, 6H)


III-86
1HNMR(CDCl3)δ 2.33(s, 3H), 2.81(s, 3H), 4.60(brs, 2H)



5.20(s, 2H), 6.92–7.18(m, 4H), 7.30–7.52(m, 6H)

















TABLE 13







I-1
m.p. 155.5–156° C.



1HNMR(acetone-d6)δ 1.77(brs, 3H), 1.79(brs, 3H), 3.37(s, 3H),



3.73(s, 3H), 4.63(brd, J=6.6Hz, 2H), 5.52(m, 1H), 6.49(1H, s),



6.83(dd, J=2.2 and 8.2Hz, 1H), 6.92(d, J=2.2Hz, 1H), 6.94



(m, 2H), 6.96(d, J=8.2Hz, 1H), 7.54(m, 2H), 7.62(brs, 1H),



7.78(s, 1H), 8.64(brs, 1H)



IR(KBr)3393, 2932, 1611, 1588, 1522, 1490, 1117,



1071, 1001 cI-3m−1


I-2
1HNMR(CDCl3)δ 2.67(s, 3H), 3.13(s, 3H), 3.21(s, 3H), 3.56(s,



3H), 3.78(s, 3H), 5.19(s, 2H), 6.84(s, 1H), 7.15(d, J=8.6Hz,



1H), 7.30–7.50(m, 9H), 7.60–7.75(m, 2H)



IR(KBr)1373, 1361, 1179, 1149, 1079, 874, 799 cm−1


I-3
m.p. 155–157° C.



1HNMR(CDCl3)δ 1.76(s, 3H), 1.81(s, 3H), 2.71(s, 3H), 3.21(s,



3H), 3.23(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 4.64(d, J=6.6Hz,



2H), 5.43–5.55(m, 1H), 6.84(s, 1H), 7.09(d, J=8.4Hz, 1H),



7.30–7.42(m, 4H), 7.65–7.75(m, 2H)



IR(KBr)1519, 1481, 1364, 1179, 1153, 1083, 970,



877, 796 cm−1


I-4
1HNMR(CDCl3)δ 3.45(s, 3H), 3.75(s, 3H), 5.16(s, 2H), 6.44(s,



1H), 6.92–7.19(m, 5H), 7.34–7.44(m, 5H), 7.57–7.66(m, 2H)



IR(KBr)3538, 3510, 3460, 3330, 1605, 1521, 1490, 1455,



1247, 1220, 1120, 1070, 1010 cm−1


I-5
m.p. 136–138° C.



1HNMR(CDCl3)δ 2.68(s, 3H), 3.13(s, 3H), 3.55(s, 3H), 3.80(s,



3H), 5.19(s, 2H), 6.86(s, 1H), 7.16(d, J=8.7Hz, 1H), 7.33–



7.49(m, 7H), 7.55–7.69(m, 2H), 7.82–7.87(m, 2H)



IR(KBr)3433, 2937, 1609, 1519, 1474, 1463, 1364, 1322, 1295,



1274, 1235, 1183, 1167, 1120, 1095, 1077, 1016 cm−1


I-6
foam



1HNMR(CDCl3)δ 1.77(s, 3H), 1.81(s, 3H), 2.72(s, 3H), 3.24(s,



3H), 3.49(s, 3H), 3.80(s, 3H), 4.64(d, J=6.9Hz, 2H), 5.50



(m, 1H), 6.86(s, 1H), 7.10(d, J=8.7Hz, 1H), 7.35(dd, J=



2.1, 8.7Hz, 1H), 7.39(d, J=2.1Hz, 1H), 7.55–7.69(m, 2H).



IR(CHCl3)3030, 1608, 1518, 1480, 1369, 1322, 1269,



1230, 1179, 1131, 1120, 1097, 1081, 1015 cm−1

















TABLE 14







I-7
m.p. 92–94° C.



1HNMR(CDCl3)δ 1.76(s, 3H), 1.82(s, 3H), 3.46(s, 3H), 3.77(s,



3H), 4.62(d, J=6.9Hz, 2H), 5.31(m, 1H), 5.71(s, 1H), 5.85(s,



1H), 6.47(s, 1H), 6.93(dd, J=1.8, 8.7Hz, 1H), 6.97(d, J=8.7Hz,



1H), 7.05(d, J=1.8Hz, 1H), 7.55–7.65(m, 2H),



7.83–7.91(m, 2H)



IR(KBr)3466, 2939, 1609, 1587, 1518, 1498, 1486, 1464, 1437,



1406, 1361, 1324, 1245, 1216, 1155, 1125, 1073 cm−1


I-8
1HNMR(CDCl3)δ 3.22(s, 3H), 3.45(s, 3H), 3.77(s, 3H), 4.74(s,



2H), 5.15(s, 2H), 6.93(s, 1H), 7.01(d, J=8.7Hz, 2H), 7.32–7.48



(m, 9H), 7.73(d, J=9.0Hz, 2H)



IR(KBr)3400, 1721, 1612, 1509, 1471, 1362, 1242,



1153, 1040, 1018 cm−1


I-9
1HNMR(CDCl3)δ 1.03(t, J=7.2Hz, 3H), 2.16(dq, J=



7.2, 6.0Hz, 2H), 3.46(s, 3H), 3.74(s, 3H), 4.68(d, J=5.4Hz,



2H), 5.70(m, 2H), 6.45(s, 1H), 6.91(d, J=8.7Hz, 2H), 6.96(brs,



2H), 7.07(brs, 1H), 7.53(d, J=8.7Hz, 2H)



IR(Nujol)3445, 3369, 1612, 1578, 1523, 1489, 1268, 1243,



1112, 1102, 1071, 1011, 998, 944, 824, 805, 781 cm−1


I-10
m.p. 174–175° C.



1HNMR(CDCl3)δ 3.11(s, 3H), 3.21(s, 3H), 3.45(s, 3H), 3.73(s,



3H), 4.49(brs, 2H), 5.18(s, 2H), 6.85(s, 1H), 7.15(d, J=8.4Hz,



1H), 7.27(dd, J=8.4Hz, J=2.1Hz, 1H), 7.35–7.49(m, 8H),



7.70(m, 2H)



IR(KBr)1519, 1467, 1360, 1346, 1331, 1295, 1272, 1229,



1180, 1151, 1122, 1101, 1081, 1022, 980, 971, 954, 875, 849



814, 798, 742, 525 cm−1


I-11
1HNMR(CDCl3)δ 1.77(s, 3H), 1.82(s, 3H), 3.22(s, 6H),



3.45(s, 3H), 3.74(s, 3H), 4.49(brs, 2H), 4.64(d, J=7.2Hz, 2H),



5.45–5.55(m, 1H), 6.85(s, 1H), 7.08(d, J=8.7Hz, 1H), 7.26(dd,



J=8.7and2.1Hz, 1H), 7.33(d, J=2.1Hz, 1H), 7.36–7.41(m,



2H), 7.65–7.75(m, 2H)



IR(KBr)3553, 3434, 1516, 1472, 1365, 1176, 1150,



973, 871 cm−1


I-12
1HNMR(DMSO-d6)δ 1.72(s, 3H), 1.77(s, 3H), 3.35(s, 3H),



3.65(s, 3H), 4.20(brs, 2H), 4.47(brt, J=4.4Hz, 1H), 4.55(brd,



J=6.6Hz, 2H), 5.40–5.57(m, 1H), 6.64(dd, J=8.2, 2.0Hz,



1H), 6.70(d, J=2.0Hz, 1H), 6.75–7.00(m, 4H), 7.40–7.55



(m, 2H)



IR(KBr)3435, 1518, 1475, 1459, 1261, 1223, 988 cm−1

















TABLE 15







I-13
1HNMR(CDCl3)δ 2.71(s, 3H), 2.84(s, 3H), 3.20(s, 3H), 3.42(s,



3H), 3.76(s, 3H), 5.13(s, 2H), 5.67(s, 1H), 6.90(s, 1H),



6.89–6.96(m, 2H), 7.00(m, J=1.8Hz, 1H), 7.32–7.50(m, 7H),



7.70(d, J=9.0Hz, 2H)


I-14
m.p. 140–141° C.



1HNMR(CDCl3)δ 2.71(s, 3H), 2.83(s, 3H), 3.15(s, 3H), 3.21(s,



3H), 3.42(s, 3H), 3.77(s, 3H), 5.16(s, 2H), 6.90(s, 1H), 7.09(d,



J=8.9Hz, 2H), 7.30–7.50(m, 9H), 7.70(d, J=8.9Hz, 2H)



IR(KBr)1642, 1516, 1467, 1362, 1180, 1151, 1118, 1050, 867,



803, 708 cm−1


I-15
m.p. 161–162° C.



1HNMR(CDCl3)δ 1.76(s, 3H), 1.81(s, 3H), 2.72(s, 3H), 2.85(s,



3H), 3.21(s, 3H), 3.23(s, 3H), 3.42(s, 3H), 3.77(s, 3H), 4.61(d,



J=6.6Hz, 2H), 5.49(t, J=6.6Hz, 1H), 6.90(S, 1H), 7.02(d, J=8.1Hz,



1H), 7.31–7.37(m, 2H), 7.38(d, J=8.9Hz, 2H), 7.70(d, J=8.9Hz,



2H)



IR(KBr)1643, 1516, 1467, 1362, 1277, 1236, 1180, 1150, 974,



882, 868, 847, 802, 710 cm−1


I-16
m.p. 206–207° C.



1HNMR(CDCl3)δ 1.71(s, 3H), 1.76(s, 3H), 2.62(s, 3H), 2.69(s,



3H), 3.27(s, 3H), 3.71(s, 3H), 4.53(d, J=6.8Hz, 2H), 5.47(t,



J=6.6Hz, 1H), 6.61(dd, J=8.3and2.1Hz, 1H), 6.71(d, J=2.1Hz,



1H), 6.86(d, J=8.7Hz, 2H), 6.87(d, J=8.3Hz, 1H), 6.95(s, 1H),



7.47(d, J=8.7Hz, 2H), 8.83(brs, 1H), 9.59(brs, 1H)



IR(KBr)3427, 3020, 1608, 1517, 1467, 1379, 1233, 1053, 1005,



839, 799, 759, 543 cm−1


I-17
m.p. 171–172° C.



1HNMR(DMSO-d6)δ 1.74(d, J=0.9Hz, 3H), 1.77(s, 3H), 2.97(s,



3H), 3.45(s, 3H), 3.51(s, 3H), 3.77(s, 3H), 4.65(d, J=6.6Hz, 2H),



5.48(m, 1H), 7.06–7.27(m, 4H), 7.48&7.74(ABq, J=9.0Hz, 4H)



IR(KBr)1523, 1483, 1394, 1366, 1271, 1175, 1151, 1087, 1071,



872, 861, 847, 796 cm−1


I-18
1HNMR(CDCl3)δ 1.76(s, 3H), 1.80(s, 3H), 3.44(s, 3H), 3.76(s,



3H), 4.63(d, J=6.6Hz, 2H), 4.99(s, 1H), 5.48–5.62(m, 1H), 6.00(s,



1H), 6.45(s, 1H), 6.88–6.97(m, 2H), 7.04(dd, J=9.0, 9.0Hz, 1H),



7.15–7.29(m, 2H), 7.45–7.60(m, 2H)



IR(KBr)3393, 1523, 1490, 1466, 1403, 1267, 1229, 1113,



1070 cm−1

















TABLE 16







I-19
1HNMR(CDCl3)δ 2.56(s, 3H), 3.21(s, 3H), 3.52(s, 3H), 3.69(s,



3H), 5.19(s, 2H), 5.76(s, 1H), 6.92(dd, J=8.4and2.0Hz, 1H),



7.04(d, J=8.4Hz, 1H), 7.05(d, J=2.0Hz, 1H), 7.35–7.51(m, 7H),



7.60(d, J=8.6Hz, 2H)


I-20
1HNMR(CDCl3)δ 2.69(s, 3H), 3.14(s, 3H), 3.21(s, 3H), 3.53(s,



3H), 3.71(s, 3H), 5.20(s, 2H), 7.18(d, J=8.7Hz, 1H), 7.34–7.50(m,



9H), 7.59(d, J=8.7Hz, 2H)


I-21
m.p. 94–95° C.



1HNMR(CDCl3)δ 2.73(s, 3H), 3.21(s, 3H), 3.24(s, 3H), 3.53(s,



3H), 3.71(s, 3H), 4.65(d, J=6.9Hz, 2H), 5.50(t, J=6.9Hz, 1H),



7.12(d, J=8.6Hz, 1H), 7.36(dd, J=8.6 and 2.1Hz, 1H), 7.41(d,



J=2.1Hz, 2H), 7.41(d, J=8.8Hz, 2H)



IR(KBr)1516, 1367, 1180, 1152, 1039, 975, 869, 799 cm−1


I-22
m.p. 148–150° C.



1HNMR(CDCl3)δ 3.42(s, 3H), 3.65(s, 3H), 4.63(d, J=6.9Hz,



2H), 4.98(brs, 1H), 5.53(t, J=6.9(Hz, 1H). 6.92–6.96(m, 4H),



7.07(s, 1H), 7.43(d, J=8.6Hz, 2H)



IR(KBr)3398, 1612, 1587, 1523, 1462, 1410, 1261, 1211, 1099,



1036, 984, 952, 919, 838, 815 cm−1


I-23
1HNMR(CDCl3)δ 2.28(t, J=6.3Hz, 1H), 2.60(s, 3H), 3.21(s, 3H),



3.55(s, 3H), 3.77(s, 3H), 4.78(d, J=6.3Hz, 2H), 5.18(s, 2H),



6.84(s, 1H), 7.06(d, J=9.0Hz, 1H), 7.29–7.48(m, 9H), 7.69(d,



J=8.7Hz, 2H)


I-24
1HNMR(CDCl3)δ 1.76(s, 3H), 1.81(s, 3H), 2.26(s, 3H), 2.50(s,



3H), 3.21(s, 3H), 3.56(s, 3H), 3.77(s, 3H), 4.57(d, J=6.2Hz, 2H),



5.51(t, J=6.2Hz, 1H), 6.83(s, 1H), 6.92(d, J=9.0Hz, 1H),



7.17–7.29(m, 2H), 7.36(d, J=8.7Hz, 2H), 7.70(d, J=8.7Hz, 2H)



IR(KBr)3434, 1608, 1512, 1479, 1364, 1234, 1175, 1150, 1078,



1017 cm−1


I-25
1HNMR(CDCl3)δ 1.75(s, 3H), 1.80(s, 3H), 2.27(s, 3H), 3.46(s,



3H), 3.74(s, 3H), 4.57(d, J=6.2Hz, 2H), 4.95(s, 1H), 5.53(t,



J=6.2Hz, 1H), 5.86(s, 1H), 6.45(s, 1H), 6.91(d, J=8.7Hz, 2H),



6.92(d, J=9.0Hz, 1H), 7.24(d, J=9.0Hz, 1H), 7.26(s, 1H), 7.53(d,



J=8.7Hz, 2H)



IR(KBr)3399, 1612, 1566, 1581, 1520, 1486, 1237, 1115, 1078,



1001 cm−1

















TABLE 17







I-26
m.p. 246–247° C.



1HNMR(DMSO-d6)δ 5.16(s, 3H), 6.84–6.87(m, 2H), 7.05(s, 2H),



7.14(s, 1H), 7.32–7.43(m, 3H), 7.49–7.64(m, 8H)



IR(KBr)3600–3100(br), 1594, 1453, 1387, 1296, 1253, 1010 cm−1


I-27
1HNMR(DMSO-d6)δ 3.38(s, 3H), 3.43(s, 3H), 5.28(s, 2H),



7.36–7.54(m, 8H), 7.69–7.86(m, 8H)



IR(KBr)1488, 1354, 1286, 1178, 1151, 1116 cm−1


I-28
m.p. 162–163° C.



1HNMR(CDCl3)δ 1.77(s, 3H), 1.82(s, 3H), 3.19(s, 3H), 3.23(s,



3H), 4.64(d, J=6.6Hz, 2H), 5.25–5.48(m, 1H), 7.09(d, J=9.0Hz,



1H), 7.36–7.40(m, 2H), 7.52(dd, J=2.4, 9.0Hz, 1H), 7.59(d,



J=2.4Hz, 1H), 7.62(s, 4H), 7.63–7.69(m, 2H)



IR(KBr)1489, 1363, 1290, 1177, 1154, 1115, 971, 860, 809 cm−1


I-29
m.p. 195° C.



1HNMR(DMSO-d6)δ 1.72(s, 3H), 1.75(s, 3H), 4.57(d, J=6.3Hz,



2H), 5.45–5.50(m, 1H), 6.84–6.87(m, 2H), 6.98–7.11(m, 3H),



7.50–7.64(m, 6H)



IR(KBr)3600–3200(br), 1609, 1594, 1497, 1257, 991 cm−1


I-30
m.p. 145–148° C.



1HNMR(CDCl3)δ 1.60–2.20(m, 6H), 2.72(s, 3H), 3.21(s, 3H),



3.24(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 4.92(m, 1H), 5.88(m, 1H),



6.02(m, 1H), 6.84(s, 1H), 7.12(d, J=8.6Hz, 1H), 7.34–7.40(m,



4H), 7.69(m, 2H)



IR(KBr)1517, 1481, 1390, 1362, 1270, 1244, 1180, 1151, 1077,



1012, 973, 960, 873, 817, 799, 521 cm−1


I-31
m.p. 108–110° C.



1HNMR(CDCl3)δ 1.60–2.20(m, 6H), 3.46(s, 3H), 3.75(s, 3H),



4.86(m, 1H), 5.02(bs, 1H), 5.75(s, 1H), 5.90(m, 1H), 5.91(s,



1H), 6.00(m, 1H), 6.45(s, 1H), 6.90–7.07(m, 5H), 7.53(m, 2H)



IR (KBr)3485, 1614, 1523, 1491, 1457, 1407, 1312, 1287, 1269,



1238, 1195, 1170, 1115, 1072, 1014 cm−1

















TABLE 18







I-32
m.p. 188–190° C.



1HNMR(CDCl3)δ 2.69(s, 3H), 3.21(s, 3H), 3.26(s, 3H), 3.56(s,



3H), 3.78(s, 3H), 4.84(m, 2H), 6.42(dt, J=15.6Hz, J=5.7Hz, 1H),



6.79(d, J=15.6Hz, 1H), 6.84(s, 1H), 7.15(d, J=8.4Hz, 1H),



7.28–7.43(m, 9H), 7.68(m, 2H)



IR(KBr)1519, 1479, 1447, 1391, 1360, 1301, 1273, 1241, 1228,



1201, 1175, 1152, 1120, 1079, 1014, 974, 959, 947, 868, 819, 795,



777, 743, 521 cm−1


I-33
m.p. 157–159° C.



1HNMR(CDCl3)δ 3.46(s, 3H), 3.75(s, 3H), 4.81(m, 2H), 4.93(bs,



1H), 5.70(s, 1H), 5.91(s, 1H), 6.45(s, 1H), 6.46(dt, J=15.9Hz,



J=6.0Hz, 1H), 6.76(d, J=15.9Hz, 1H), 6.90–7.09(m, 5H),



7.26–7.46(m, 5H), 7.54(m, 2H)



IR(KBr)3466, 1611, 1522, 1489, 1461, 284, 1248, 1192, 1165,



1114, 1073 cm−1


I-34
m.p. 127–129° C.



1HNMR(CDCl3)δ 1.03and1.04(botht, bothJ=8.0Hz, total3H),



2.07–2.19(m, 2H), 2.71and2.72(boths, total3H), 3.21(s, 3H),



3.24(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 4.60and4.71(bothm,



total2H), 5.66–5.75and5.90–5.99(bothm, total2H), 6.84(s, 1H),



7.09(d, J=8.4Hz, 1H), 7.33–7.41(m, 4H), 7.68(m, 2H)



IR(KBr)1519, 1482, 1390, 1362, 1232, 1180, 1150, 1077, 974,



873, 815, 799, 522 cm−1


I-35
m.p. 166–168° C.



1HNMR(CDCl3)δ 1.04and1.05(botht, bothJ=7.5Hz, total3H),



2.09–2.19(m, 2H), 3.46(s, 3H), 3.74(s, 3H), 4.58and4.68(bothm,



total2H), 5.01(bs, 1H), 5.69–5.78and5.87–5.95(bothm, total4H),



6.45(s, 1H), 6.90–7.06(m, 5H), 7.53(m, 2H)



IR(KBr)3531, 3489, 3306, 1523, 1492, 1459, 1408, 1314, 1287,



1270, 1255, 1234, 1224, 1118, 1072, 1018, 1005, 822 cm−1


I-36
m.p. 148–150° C.



1HNMR(CDCl3)δ 1.62(s, 3H), 1.69(s, 3H), 1.76(s, 3H),



2.08–2.20(m, 4H), 2.71(s, 3H), 3.21(s, 3H), 3.24(s, 3H), 3.56(s,



3H), 3.78(s, 3H), 4.66(d, J=6.3Hz, 2H), 5.09(m, 1H), 5.50(t,



J=6.3Hz, 1H), 6.84(s, 1H), 7.10(d, J=8.4Hz, 1H), 7.33–7.41(m,



4H), 7.68(m, 2H)



IR(KBr)1519, 1480, 1464, 1449, 1389, 1366, 1291, 1271, 1233,



1200, 1176, 1150, 1118, 1079, 1012, 973, 946, 876, 841, 816, 801,



523, 510 cm−1

















TABLE 19







I-37
1HNMR(CDCl3)δ 1.58(s, 3H), 1.63(s, 3H), 1.70(s, 3H),



2.05–2.20(m, 4H), 3.46(s, 3H), 3.75(s, 3H), 4.64(d, J=6.3Hz,



2H), 4.95(bs, 1H), 5.11(m, 1H), 5.53(m, 1H), 5.70(s, 1H), 5.90(s,



1H), 6.45(s, 1H), 6.91–7.08(m, 5H), 7.54(m, 2H)


I-38
m.p. 149–151° C.



1HNMR(CDCl3)δ 1.68(s, 3H), 1.74(s, 3H), 2.55(m, 2H), 2.73(s,



3H), 3.21(s, 3H), 3.22(s, 3H), 3.56(s, 3H), 3.77(s, 3H), 4.07(t,



J=6.8Hz, 2H), 5.21(m, 1H), 6.84(s, 1H), 7.08(d, J=8.2Hz, 1H),



7.32–7.40(m, 4H), 7.68(m, 2H)



IR(KBr)1520, 1483, 1389, 1363, 1296, 1180, 1151, 1079, 975,



872, 815, 799, 521 cm−1


I-39
m.p. 105–107° C.



1HNMR(CDCl3)δ 1.68(s, 3H), 1.75(s, 3H), 2.53(m, 2H), 3.54(s,



3H), 3.74(s, 3H), 4.06(t, J=6.8Hz, 2H), 5.01(bs, 1H), 5.22(m, 1H),



5.69(s, 1H), 5.90(s, 1H), 6.45(s, 1H), 6.90–7.06(m, 5H), 7.53(m,



2H)



IR(KBr)3477, 3388 1523, 1489, 1469, 1402, 1285, 1261, 1248,



1227, 1196, 1175, 1164, 1115, 1100, 1073, 1011 cm−1


I-40
m.p. 155–157° C.



1HNMR(CDCl3)δ 1.89(t, J=2.4Hz, 3H), 3.45(s, 3H), 3.75(s, 3H),



4.74(q, J=2.4Hz, 2H), 5.00(bs, 1H), 5.66(s, 1H), 5.92(s, 1H),



6.45(s, 1H), 6.90–7.08(m, 5H), 7.54(m, 2H)



IR(KBr)3446, 2224, 1523, 1488, 1402, 1266, 1238, 1203, 1187,



1166, 1102, 1068, 1009 cm−1


I-41
1HNMR(CDCl3)δ 2.19(s, 3H), 3.45(s, 3H), 3.75(s, 3H), 4.62(m,



2H), 4.92(bs, 1H), 5.60(bs, 1H), 5.92(s, 1H), 5.99(m, 1H), 6.45(m,



1H), 6.91–7.08(m, 5H), 7.53(m, 2H)


I-42
oil



1HNMR(CDCl3)δ 1.76(s, 3H), 1.81(s, 3H), 2.87(s, 3H), 3.22(s,



6H), 3.55(s, 3H), 3.80(s, 3H), 4.66(d, J=7.5Hz, 2H), 5.61(m, 1H),



6.84(s, 1H), 7.37–7.41(m, 3H), 7.61(d, J=2.1Hz, 1H), 7.67(m, 2H)

















TABLE 20







I-43
m.p. 132–136° C.



1HNMR(CDCl3)δ 1.74(s, 3H), 1.82(s, 3H), 3.44(s, 3H), 3.76(s,



3H), 4.62(m, 2H), 5.05(brs, 1H), 5.61(m, 1H), 5.79(s, 1H), 6.02(s,



1H), 6.44(s, 1H), 6.92(m, 2H), 7.04(d, J=2.1Hz, 1H), 7.20(d,



J=2.1Hz, 1H), 7.53(m, 2H)



IR(KBr)3495, 3422, 1611, 1520, 1473, 1400, 1355, 1315, 1280,



1227, 1194, 1173, 1111, 1077, 1023 cm−1


I-44
m.p. 148–149° C.



1HNMR(CDCl3)δ 1.60(s, 3H), 1.70(s, 3H), 2.32–2.39(m, 2H),



2.65(s, 3H), 2.76–2.81(m, 2H), 3.21(s, 3H), 3.24(s, 3H), 3.56(s,



3H), 3.78(s, 3H), 5.16–5.21(m, 1H), 6.85(s, 1H), 7.30–7.40(m,



5H), 7.66–7.71(m, 2H)



IR(KBr)1480, 1390, 1361, 1181, 1150, 1075 cm−1


I-45
m.p. 73–75° C.



1HNMR(CDCl3)δ 1.63(s, 3H), 1.72(s, 3H), 2.32–2.39(m, 2H),



2.64–2.70(m, 2H), 3.46(s, 3H, 3.74(s, 3H), 4.83(s, 1H), 4.95(s,



1H), 5.27–5.31(m, 1H), 5.92(s, 1H), 6.45(s, 1H), 6.89–7.00(m,



4H), 7.21(d, J=10.5Hz, 1H), 7.52–7.55(m, 2H)



IR(KBr)3600–3200(br), 3100–2800(br), 1612, 1579, 1523, 1487,



1452, 1400, 1360, 1226, 1174, 1111, 1072 cm−1


I-46
1HNMR(CDCl3)δ 3.45(s, 3H), 3.75(s, 3H), 4.65(m, 2H), 4.85(s,



1H), 5.33(m, 1H), 5.44(m, 1H), 5.67(s, 1H), 5.91(s, 1H), 6.10(m,



1H), 6.45(s, 1H), 6.92(m, 2H), 6.95(m, 2H), 7.08(m, 1H),



7.54(m, 2H)


I-47
1HNMR(acetone-d6)δ 3.39(s, 3H), 3.72(s, 3H), 5.20(s, 2H),



6.48(s, 1H), 6.83(dd, J=2.0Hz, J=8.4Hz, 1H), 6.93(m, 2H), 6.96(d,



J=2.0Hz, 1H), 7.04(d, J=8.4Hz, 1H), 7.34–7.45(m, 3H), 7.52(m,



2H), 7.52–7.58(m, 2H)



IR(CHCl3)3522, 3348, 1699, 1612, 1589, 1521, 1489, 1458, 1402,



1288, 1114, 1071, 935 cm−1


I-48
1HNMR(acetone-d6)δ 1.28(t, J=7.2Hz, 3H), 3.39(s, 3H), 3.72(s,



3H), 4.25(q, J=7.2Hz, 2H), 4.78(s, 2H), 6.49(s, 1H), 6.83(dd,



J=1.8and8.4Hz, 1H), 6.93(m, 2H), 6.96(d, J=1.8Hz, 1H), 6.97(d,



J=8.4Hz, 1H), 7.52(m, 2H), 7.63(s, 1H), 7.83(s, 1H), 8.50(s, 1H)


I-49
1HNMR(acetone-d6)δ 1.75(m, 3H), 3.39(s, 3H), 3.72(s, 3H),



4.56(m, 2H), 5.71–5.82(m, 1H), 5.84–5.96(m, 1H), 6.48(s, 1H),



6.82(dd, J=2.0and8.4Hz, 1H), 6.93(d, J=2.0Hz, 1H), 6.93(m, 2H),



6.95(d, J=8.4Hz, 1H), 7.52(m, 2H)

















TABLE 21







I-50
1HNMR(acetone-d6)δ 1.75(m, 3H), 3.39(s, 3H), 3.72(s, 3H),



4.72(m, 2H), 5.73–5.75(m, 2H), 6.48(s, 1H), 6.83(dd,



J=2.0and7.8Hz, 1H), 6.92–6.95(m, 3H), 6.97(d, J=7.8Hz, 1H),



7.52(m, 2H)


I-51
1HNMR(acetone-d6)δ 1.77(s, 3H), 1.79(s, 3H), 3.41(s, 3H),



3.72(s, 3H), 4.66(m, 2H), 5.53(m, 1H), 6.49(s, 1H), 6.85(m, 2H),



7.04(d, J=8.1Hz, 1H), 7.10(dd, J=2.1and8.1Hz, 1H), 7.19(d,



J=2.1Hz, 1H), 7.25(m, 2H)


I-52
1HNMR(CDCl3)δ 2.58(t, J=2.2Hz, 1H), 2.73(s, 3H), 3.22(s, 3H),



3.26(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 4.83(d, J=2.2Hz, 2H),



6.85(s, 1H), 7.21(d, J=8.41Hz, 1H), 7.35–7.46(m, 4H),



7.64–7.74(m, 2H)


I-53
1HNMR(CDCl3)δ 3.45(s, 3H), 3.76(s, 3H), 4.36(d, J=1.5Hz, 1H),



4.55(s, 2H), 4.76(dd, J=1.8and0.6Hz, 1H), 5.02(brs, 1H), 5.97(d,



J=0.9Hz, 1H), 6.45(s, 1H), 6.90–6.96(m, 2H), 6.96–7.05(m, 2H),



7.10–7.12(m, 1H), 7.50–7.58(m, 2H


I-54
1HNMR(CDCl3)δ 1.76(s, 3H), 1.82(s, 3H), 2.61(s, 3H), 3.53(s,



3H), 3.77(s, 3H), 4.61(d, J=6.9Hz, 2H), 5.17(brs, 1H),



5.45–5.50(m, 1H), 5.72(s, 1H), 6.84(s, 1H), 6.88–7.0O(m, 4H),



7.02(d, J=1.8Hz, 1H), 7.50–7.57(m, 2H)


I-55
1HNMR(CDCl3)δ 0.99(d, J=6.5Hz, 6H), 1.74(q, J=6.5Hz, 2H),



1.85(m, 1H), 3.46(s, 3H), 3.75(s, 3H), 4.12(t, J=6.5Hz, 2H),



4.97(s, 1H), 5.65(s, 1H), 5.90(s, 1H), 6.45(s, 1H), 6.92(m, 2H),



6.95(m, 2H), 7.06(m, 1H), 7.54(m, 2H)


I-56
1HNMR(CDCl3)δ 1.34(s, 3H), 1.35(s, 3H), 3.15(dd,



J=3.6and6.6Hz, 1H), 3.39(s, 3H), 3.72(s, 3H), 4.10(dd,



J=6.6and11.1Hz, 1H), 4.34(dd, J=3.6and 11.1Hz, 1H), 6.49(s, 1H),



6.83(dd, J=1.8and8.1Hz, 1H), 6.93(d, J=8.7Hz, 2H), 6.94(d,



J=1.8Hz, 1H), 7.00(d, J=8.1Hz, 1H), 7.52(d, J=8.7Hz, 2H)


I-57
1HNMR(CDCl3)δ 2.68(s, 3H), 3.13(s, 3H), 3.53(s, 3H), 3.78(s,



3H), 5.19(s, 2H), 6.83(s, 1H), 7.10–7.19(m, 3H), 7.31–7.50(m,



7H), 7.57–7.64(m, 2H)



IR(KBr)1607, 1520, 1481, 1373, 1231, 1176, 1119, 1078 cm−1


I-58
1HNMR(CDCl3)δ 1.76(s, 3H), 1.82(s, 3H), 2.72(s, 3H), 3.23(s,



3H), 3.53(s, 3H), 3.78(s, 3H), 3.78(s, 3H), 4.64(d, J=6.6Hz, 2H),



6.84(t, J=6.6Hz, 1H), 5.83(s, 1H), 7.06–7.20(m, 3H),



7.31–7.40(m, 2H), 7.56–7.65(m, 2H)



IR(KBr)1603, 1521, 1483, 1376, 1366, 1176, 1085 cm−1

















TABLE 22







I-59
1HNMR(CDCl3)δ 1.76(s, 3H), 1.82(s, 3H), 3.45(s, 3H), 3.75(s,



3H), 4.62(d, J=6.9Hz, 1H), 5.71(brs, 1H), 5.89(s, 1H), 6.44(s, 1H),



6.90–7.19(m, 5H), 7.56–7.67(m, 2H)



IR(KBr)3545, 3385, 1605, 1586, 1561, 1520, 1384, 1311, 1284,



1225, 1121, 1096 cm−1


I-60
1HNMR(CDCl3)δ 3.49(s, 3H), 3.74(s, 3H), 5.15(s, 2H), 5.68(s,



1H), 5.91(s, 1H), 6.02(s, 2H), 6.43(s, 1H), 6.88–7.19(m, 6H),



7.31–7.48(m, m, 5H)



IR(CHCl3)3535, 1615, 1588, 1519, 1500, 1482, 1410, 1290, 1241,



1204, 1092, 1041 cm−1


I-61
1HNMR(CDCl3)δ 1.76(s, 3H), 1.81(s, 3H), 2.73(s, 3H), 3.23(s,



3H), 3.57(s, 3H), 3.77(s, 3H), 4.64(d, J=6.6Hz, 1H), 5.50(t,



J=6.6Hz, 1H), 6.03(s, 2H), 6.83(s, 1H), 6.91(d, J=8.1Hz, 1H),



7.08(d, J=8.1Hz, 1H), 7.09(d, J=8.1Hz, 1H), 7.14(s, 1H), 7.34(d,



J=8.1Hz, 1H), 7.39(s, 1H)



IR(CHCl3)1607, 1518, 1477, 1453, 1369, 1240, 1178, 1081 cm−1


I-62
1HNMR(CDCl3)δ 1.76(s, 3H), 1.82(s, 3H), 3.49(s, 3H), 3.74(s,



3H), 4.61(d, J=6.9Hz, 2H), 5.53(t, J=6.9Hz, 1H), 5.68(s, 1H),



6.02(s, 2H), 6.43(s, 1H), 6.88–6.96(m, 3H), 7.03–7.18(m, 3H)



IR(KBr)3494, 1610, 1583, 1561, 1519, 1480, 1460, 1409, 1286,



1243, 1191, 1127, 1089, 1036 cm−1


I-63
m.p. 201–202° C.



1HNMR(CDCl3)δ 3.78(s, 6H), 5.16(s, 4H), 5.69(s, 2H), 6.93(s,



2H), 6.99(d, J=8.4Hz, 2H), 7.08(dd, J=2.1 and 8.4Hz, 2H), 7.22(d,



J=2.1Hz, 2H), 7.37–7.47(m, 10H),



IR(KBr)3600–3100(br), 1584, 1523, 1454, 1272, 1245, 1210, 1130



cm−1


I-64
m.p. 173–175° C.



1HNMR(CDCl3)δ 3.12(s, 6H), 3.80(s, 6H), 5.18(s, 4H), 6.92(s,



2H), 7.12(d, J=8.7Hz, 2H), 7.36–7.50(m, 12H), 7.60(d, J=2.1Hz,



2H)



IR(KBr)1523, 1492, 1356, 1290, 1263, 1210, 1182, 1114 cm−1

















TABLE 23







I-65
1HNMR(CDCl3)δ 1.76(d, J=0.9Hz, 6H), 1.81(d, J=0.6Hz, 6H),



3.22(s, 6H), 3.80(s, 6H), 4.63(d, J=6.6Hz, 4H), 5.48–5.53(m, 2H),



6.92(s, 2H), 7.05(d, J=8.4Hz, 2H), 7.48(dd, J=2.1 and 8.4Hz, 2H),



7.57(d, J=2.1Hz, 2H)



IR(KBr)1523, 1492, 1468, 1353, 1286, 1258, 1213, 1174, 1108



cm−1


I-66
1HNMR(CDCl3)δ 1.76(s, 6H), 1.82(s, 6H), 3.78(s, 6H), 4.62(d,



J=6.9Hz, 4H), 5.50–5.55(m, 2H), 5.71(s, 2H), 691–6.94(m, 4H),



7.08(d, J=2.1 and 8.4Hz, 2H), 7.57(d, J=2.1Hz, 2H)



IR(KBr)3600–3200(br), 1523, 1492, 1271, 1242, 1210, 1186, 1034



cm−1


I-67
1HNMR(CDCl3)δ 1.77(s, 3H), 1.81(s, 3H), 3.22(s, 3H), 3.28(s,



3H), 3.79(s, 3H), 3.80(s, 3H), 4.63(d, J=6.6Hz, 2H), 5.48–5.53(m,



1H), 6.92(s, 1H), 6.93(s, 1H), 7.06(d, J=8.4Hz, 1H), 7.13(d,



J=8.4Hz, 2H), 7.42–7.51(m, 3H), 7.57(d, J=2.1Hz, 1H)



IR(KBr)3600–3200(br), 1525, 1493, 1362, 1293, 1210, 1172, 1107



cm−1


I-68
m.p. 168–169° C.



1HNMR(CDCl3)δ 3.18(s, 3H), 3.78(s, 3H), 3.79(s, 3H), 5.17(s,



2H), 5.71(s, 1H), 6.92(s, 1H), 6.96(s, 1H), 6.99(d, J=8.7Hz, 1H),



7.08(dd, J=2.1 and 8.7Hz, 1H), 7.24(d, J=2.1Hz, 1H), 7.26–7.48(m,



7H)



IR(KBr)3600–3200(br), 1488, 1382, 1369, 1269, 1206, 1174, 1146



cm−1


I-69
m.p. 155–157° C.



1HNMR(CDCl3)δ 3.12(s, 3H), 3.19(s, 3H), 3.80(s, 6H), 5.18(s,



2H), 6.92(s, 1H), 6.95(s, 1H), 7.12(d, J=8.7Hz, 1H), 7.32–7.51(m,



8H), 7.60–7.65(m, 3H)



IR(KBr)1491, 1363, 1210, 1174, 1151, 1114 cm−1


I-70
m.p. 109–110° C.



1HNMR(CDCl3)δ 1.77(s, 3H), 1.81(s, 3H), 3.19(s, 3H), 3.23(s,



3H), 3.80(s, 6H), 4.64(d, J=6.6Hz, 2H), 5.05–5.30(m, 1H), 6.92(s,



1H), 6.95(s, 1H), 7.06(d, J=8.7Hz, 1H), 7.33–7.37(m, 2H),



7.49(dd, J=2.1 and 8.7Hz, 1H), 7.58(d, J=2.1Hz, 1H), 7.61–7.64(m,



2H)



IR(KBr)1522, 1489, 1368, 1351, 1294, 1260, 1212, 1178, 1149,



1114, 975 cm−1

















TABLE 24







I-71
1HNMR(CDCl3)δ 1.72(s, 3H), 1.76(s, 3H), 3.72(s, 3H), 3.73(s,



3H), 4.56(d, J=6.6Hz, 2H), 5.46–5.49(brs, 1H), 6.79–6.82(m, 2H),



6.88–7.01(m, 5H), 7.31–739(m, 2H), 8.89(s, 1H), 9.45(s, 1H)



IR(KBr)3600–3100(br), 1524, 1493, 1458, 1386, 1261, 1206, 1010



cm−1


I-72
m.p. 123–124° C.



1HNMR(CDCl3)δ 1.77(s, 3H), 1.81(s, 3H), 3.19(s, 3H), 3.80(s,



6H), 4.64(d, J=6.9Hz, 2H), 5.52–5.57(m, 1H), 6.93(s, 1H), 6.94(s,



1H), 7.04(t, J=8.7Hz, 1H), 7.26–7.39(m, 3H), 7.60–7.65(m, 2H)



IR(KBr)1521, 1494, 1463, 1379, 1265, 1211, 1174, 1154, 1130



cm−1


I-73
m.p. 118–119° C.



1HNMR(CDCl3)δ 1.77(s, 3H), 1.81(s, 3H), 3.79(s, 3H), 3.80(s,



3H), 4.63(d, J=Hz, 2H), 4.86(s, 1H), 5.52–5.57(m, 1H),



6.88–6.93(m, 4H), 7.03(t, J=8.7Hz, 1H), 7.26–7.29(m, 1H),



7.37(dd, J=2.4and 12.9Hz, 1H), 7.40–7.50(m, 2H)



IR(KBr)3600–3100(br), 1525, 1492, 1466, 1381, 1263, 1206 cm−1


I-74
1HNMR(CDCl3)δ 2.63(s, 3H), 3.19(s, 3H), 5.18(s, 2H), 5.74(s,



1H), 7.03(d, J=8.4Hz, 1H), 7.07(dd, J=2.1and8.4Hz, 1H), 7.12(d,



J=2.1Hz, 1H), 7.36–7.68(m, 12H)



IR(KBr)3700–3200(br), 1486, 1367, 1353, 1197, 1179, 1147 cm−1


I-75
1HNMR(CDCl3)δ 2.80(s, 3H), 3.14(s, 3H), 3.19(s, 3H), 5.20(s,



2H), 7.18(d, J=8.4Hz, 1H), 7.38–7.68(m, 14H)



IR(KBr)1485, 1361, 1186, 1156, 1107 cm−1


I-76
1HNMR(CDCl3)δ 1.78(s, 3H), 1.82(s, 3H), 2.81(s, 3H), 3.19(s,



3H), 3.26(s, 3H), 4.65(d, J=7.2Hz, 1H), 5.47–5.52(m, 1H), 7.11(d,



J=8.7Hz, 1H), 7.37–7.67(m, 9H)



IR(KBr)1486, 1365, 1186, 1154, 1106, 973, 926, 870, 810 cm−1

















TABLE 25







I-77
m.p. 174–176° C.



1HNMR(CDCl3)δ 1.72(s, 3H), 1.76(s, 3H), 4.55(d, J=6.0Hz, 2H),



5.45–5.49(m, 1H), 6.82–7.43(m, 10H), 8.84(s, 1H), 9.45(s, 1H),



9.53(s, 1H)



IR(KBr)3600–3100(br), 1610, 1594, 1532, 1496, 1444, 1409,



1305, 1245, 1209 cm−1


I-78
m.p. 134–135° C.



1HNMR(CDCl3)δ 3.78(s, 3H), 3.79(s, 3H), 5.17(s, 2H), 5.70(s,



1H), 6.91(s, 1H), 6.95(s, 1H), 6.99(d, J=8.4Hz, 1H), 7.07–7.14(m,



3H), 7.22(d, J=2.1Hz, 1H), 7.36–7.47(m, 5H), 7.52–7.57(m, 2H)



IR(KBr)3600–3100(br), 1524, 1494, 1462, 1381, 1273, 1248, 1213



cm−1


I-79
1HNMR(CDCl3)δ 3.12(s, 3H), 3.79(s, 3H), 3.80(s, 3H), 5.18(s,



2H), 6.92(s, 1H), 6.94(s, 1H), 7.09–7.15(m, 3H), 7.38–7.56(m,



8H), 7.60(d, J=2.1Hz, 1H)



IR(KBr)1522, 1493, 1467, 1387, 1365, 1279, 1213, 1112 cm−1


I-80
m.p. 110–111° C.



1HNMR(CDCl3)δ 1.77(s, 3H), 1.81(s, 3H), 3.22(s, 3H), 3.78(s,



3H), 3.80(s, 3H), 4.63(d, J=6.9Hz, 2H), 5.50–5.57(m, 1H), 6.91(s,



1H), 6.94(s, 1H), 7.04–7.14(m, 3H), 7.47–7.58(m, 4H)



IR(KBr)1552, 1493, 1364, 1212, 1110, 970 cm−1


I-81
1HNMR(CDCl3)δ 1.77(s, 3H), 1.82(s, 3H), 3.78(s, 3H), 3.79(s,



3H), 4.62(d, J=6.9Hz, 2H), 5.50–5.55(m, 1H), 5.72(s, 1H),



6.91–6.95(m, 3H), 7.06–7.14(m, 3H), 7.20(d, J=1.8Hz, 1H),



7.52–7.57(m, 2H)



IR(KBr)3536, 1520, 1493, 1386, 1271, 1241, 1210 cm−1


I-82
1HNMR(CDCl3)δ 1.29(t, J=7.2Hz, 3H), 1.76(s, 3H), 1.79(s, 3H),



3.78(s, 6H), 3.78(q, 2H), 4.64(d, J=6.3Hz, 2H), 4.72(s, 2H),



5.53–5.78(m, 1H), 6.61(s, 1H), 6.94(s, 1H), 6.98(d, J=8.7Hz, 1H),



7.09–7.20(m, 4H), 7.52–7.57(m, 2H)



IR(KBr)1758, 1524, 1496, 1461, 1387, 1263, 1209, 1147 cm−1

















TABLE 26







I-83
1HNMR(CDCl3)δ 2.76(s, 3H), 3.21(s, 3H), 3.55(s, 3H), 3.77(s,



3H), 5.26(s, 2H), 6.85(s, 1H), 7.17(d, J=8.7Hz, 1H), 7.31–7.50(m,



8H), 7.60–7.71(m, 3H), 7.92(s, 1H)



IR(KBr)1684, 1606, 1512, 1478, 1177, 1150, 1080, 1016 cm−1


I-84
1HNMR(CDCl3)δ 1.26(t, J=7.2Hz, 3H), 3.08(s, 3H), 3.22(s, 3H),



3.31(s, 3H), 3.74(s, 3H), 4.16(q, J=7.2Hz, 2H), 5.17(s, 2H),



6.44(d, J=16.5Hz, 1H), 6.89(s, 1H), 7.13(s, 2H), 7.27(d, J=8.4Hz,



1H), 7.35–7.50(m, 8H), 7.69(d, J=8.4Hz, 2H)



IR(KBr)1708, 1633, 1513, 1465, 1367, 1271, 1230, 1176, 1151,



1120, 1017 cm−1


I-85
1HNMR(CDCl3)δ 1.26(t, J=7.2Hz, 3H), 3.22(s, 3H), 3.31(s, 3H),



3.74(s, 3H), 4.16(q, J=7.2Hz, 2H), 5.15(s, 2H), 5.70(s, 1H),



6.53(d, J=16.5Hz, 1H), 6.69(dd, J=8.4and2.4Hz, 1H), 6.88(s, 2H),



7.00(d, J=8.4Hz, 1H), 7.33–7.50(m, 8H), 7.70(d, J=8.4Hz, 2H)



IR(KBr)3398, 1675, 1627, 1581, 1512, 1465, 1370, 1284, 1256,



1221, 1148, 1074, 1017 cm−1


I-86
1HNMR(CDCl3)δ 2.53(s, 3H), 3.21(s, 3H), 3.56(s, 3H), 3.77(s,



3H), 4.58(s, 2H), 5.24(s, 2H), 6.83(s, 1H), 6.96(d, J=8.4Hz, 1H),



7.28–7.57(m, 9H), 7.69(d, J=8.4Hz, 2H)



IR(KBr)1605, 1512, 1479, 1366, 1233, 1175, 1149, 1080, 1015



cm−1


I-87
1HNMR(CDCl3)δ 1.76(s, 3H), 1.81(s, 3H), 3.27(s, 3H), 3.78(s,



3H), 3.79(s, 3H), 4.63(d, J=6.6Hz, 2H), 5.40–5.50(m, 1H), 5.71(s,



1H), 6.07(s, 1H), 6.91–6.95(m, 3H), 7.05–7.20(m, 3H),



7.43–7.51(m, 2H)



IR(KBr)3600–3200(br), 1617, 1525, 1494, 1464, 1361, 1292,



1208, 1178, 1101, 1033 cm−1


I-88
1HNMR(CDCl3)δ 2.57(s, 3H), 3.20(s, 3H), 3.56(s, 3H), 3.79(s,



3H), 5.18(s, 2H), 6.84(s, 1H), 7.06–7.15(m, 1H), 7.20–7.40(m,



9H), 7.47–7.57(m, 2H), 7.60–7.75(m, 3H), 8.20–8.25(m, 2H)


I-89
1HNMR(CDCl3)δ 3.44(s, 3H), 3.75(s, 3H), 5.01(s, 1H), 5.18(s,



2H), 6.01(s, 1H), 6.45(s, 1H), 6.88–6.97(m, 2H), 7.07(dd,



J=8.4and 8.4Hz, 1H), 7.15–7.21(m, 1H), 7.27(dd,



J=12.3and2.1Hz, 1H), 7.29–7.43(m, 3H), 7.45–7.56(m, 4H)

















TABLE 27







I-90
1HNMR(CDCl3)δ 1.68(s, 3H), 1.75(d, J=0.9Hz, 3H), 2.55(dt,



J=6.9and6.9Hz, 2H), 2.70(s, 3H), 3.21(s, 3H), 3.55(s, 3H), 3.77(s,



3H), 4.01(t, J=6.9Hz, 2H), 5.17–5.28(m, 1H), 6.84(s, 1H),



7.04(dd, J=8.4and8.4Hz, 1H), 7.11–7.22(m, 2H), 7.34–7.42(m,



2H), 7.65–7.75(m, 2H)



IR(KBr)1522, 1483, 1361, 1352, 1176, 1156, 1079, 963, 873, 801



cm−1


I-91
1HNMR(CDCl3)δ 2.96(s, 3H), 3.52(s, 3H), 3.58(s, 6H), 3.73(s,



3H), 4.89(s, 2H), 5.19(s, 2H), 5.23(s, 2H), 5.25(s, 2H), 6.68(s,



1H), 6.98(d, J=8.4Hz, 1H), 7.04(dd, J=8.4and2.1Hz, 1H), 7.11(m,



2H), 7.25(d, J=2.1Hz, 1H), 7.30–7.40(m, 5H), 7.51(m, 2H)



IR(KBr)2952, 2935, 2896, 1609, 1521, 1477, 1463, 1438, 1383,



1269, 1249, 1228, 1183, 1153, 1130, 1116, 1078, 1066, 1020,



1008, 984, 944, 922, 903, 832, 801, 730 cm−1


I-92
mp 122–124° C.



1HNMR(CDCl3)δ 2.70(brs, 3H), 3.55–3.60(br, 2H), 3.60(s, 3H),



3.75(s, 3H), 3.81–3.83(m, 2H), 3.87(s, 3H), 5.15(s, 2H), 5.68(s,



1H), 6.69(s, 1H), 6.94(dd, J=2.1, 8.4Hz, 1H), 6.97–7.03(m, 3H),



7.07(d, J=1.8Hz, 1H), 7.38–7.48(m, 5H), 7.51–7.56(m, 2H)



IR(KBr)3600–2800(br), 1607, 1597, 1550, 1518, 1477, 1462,



1452, 1392, 1289, 1248, 1228, 1175, 1122, 1096, 1084, 1015 cm−1


I-93
1HNMR(CDCl3)δ 2.59(dt, J=6.6, 6.6Hz, 2H), 3.45(s, 3H), 3.74(s,



3H), 4.15(t, J=6.6Hz, 2H), 5.15(dm, J=10.2Hz, 1H), 5.21(dm,



J=17.1Hz, 1H), 5.90(m, 1H), 6.45(s, 1H), 6.92(d, J=8.4Hz, 2H),



6.95(s, 2H), 7.06(brs, 1H), 7.53(d, J=8.4Hz, 2H)



IR(Nujol)3570, 3525, 3336, 3205, 1616, 1596, 1524, 1493, 1409,



1315, 1286, 1264, 1239, 1225, 1117, 1072, 821, 783 cm−1


I-94
1HNMR(CDCl3)δ 0.36(m, 2H), 0.66(m, 2H), 1.31(m, 1H), 3.45(s,



3H), 3.74(s, 3H), 3.91(d, J=7.2Hz, 2H), 6.44(s, 1H), 6.91(d,



J=8.7Hz, 2H), 6.93(m, 2H), 7.07(d, J=1.8Hz, 1H), 7.53(d,



J=8.7Hz, 2H)



IR(Nujol)3570, 3491, 3364, 3178, 1617, 1598, 1583, 1524, 1494,



1408, 1313, 1285, 1266, 1240, 1224, 1115, 1072, 1011, 822, 786



cm−1


I-95
1HNMR(CDCl3)δ 1.86(s, 3H), 3.45(s, 3H), 3.74(s, 3H), 4.54(s,



2H), 5.04(brs, 1H), 5.12(brs, 1H), 6.45(s, 1H), 6.91(d, J=8.7Hz,



2H), 6.95(m, 2H), 7.08(brs, 1H), 7.53(d, J=87Hz, 2H)



IR(Nujol)3536, 3364, 3179, 1614, 1586, 1524, 1493, 1407, 1309,



1284, 1265, 1238, 1226, 1115, 1073, 1011, 887, 821, 782 cm−1

















TABLE 28







I-96
1HNMR(CDCl3)δ 2.58(t, J=2.4Hz, 1H), 3.45(s, 3H), 3.71(s, 3H),



4.79(d, J=2.4Hz, 2H), 6.45(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.98(dd,



J=8.4, 2.1Hz, 1H), 7.07(d, J=8.4Hz, 1H), 7.09(d, J=2.1Hz, 1H),



7.53(d, J=8.7Hz, 2H)



IR(Nujol)3410, 3282, 1612, 1589, 1523, 1489, 1404, 1226, 1114,



1071, 1015, 826 cm−1


1-97
1HNMR(CDCl3)δ 2.71(s, 3H), 3.21(s, 3H), 3.38(s, 3H), 3.56(s,



3H), 3.78(s, 3H), 5.47(s, 2H), 6.84(s, 1H), 7.00(d, J=8.6Hz, 1H),



7.34(dd, J=8.6, 2.0Hz, 1H), 7.38(d, J=8.8Hz, 2H), 7.46(d,



J=2.0Hz, 1H), 7.55(m, 2H), 7.67(m, 1H), 7.68(d, J=8.8Hz, 2H),



7.99(m, 2H)


I-98
m.p. 200–203° C.



1HNMR(CDCl3)δ 2.38(s, 3H), 2.67(s, 3H), 3.12(s, 3H), 3.21(s,



3H), 3.56(s, 3H), 3.77(s, 3H), 5.14(s, 2H), 6.84(s, 1H), 7.15(d,



J=8.7Hz, 1H), 7.21(d, J=8.1Hz, 2H), 7.34(d, J=8.1Hz, 2H),



7.34(dd, J=8.7, 2.4Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.40(d,



J=2.4Hz, 1H), 7.68(d, J=8.7Hz, 2H)



IR(Nujol)1608, 1520, 1480, 1359, 1173, 1156, 1078, 1016, 976,



948, 872, 818, 791 cm−1


I-99
1HNMR(CDCl3)δ 2.72(s, 3H), 3.13(s, 3H), 3.21(s, 3H), 3.55(s,



3H), 3.78(s, 3H), 5.15(s, 2H), 6.84(s, 1H), 7.09(d, J=8.7Hz, 1H),



7.12(dd, J=8.7, 7.2Hz, 1H), 7.35(dd, J=8.7, 2.1Hz, 1H), 7.38(d,



J=8.7Hz, 2H), 7.40(d, J=2.1Hz, 1H), 7.45(dd, J=8.7, 5.1Hz, 1H),



7.68(d, J=8.7Hz, 2H)


I-100
1HNMR(CDCl3)δ 2.76(s, 3H), 3.19(s, 3H), 3.21(s, 3H), 3.55(s,



3H), 3.78(s, 3H), 5.25(s, 2H), 6.85(s, 1H), 7.13(d, J=8.4Hz, 1H),



7.32(dd, J=8.4, 1.8Hz, 1H), 7.36(dd, J=8.4, 1.8Hz, 1H), 7.38(d,



J=8.7Hz, 2H), 7.42(d, J=1.8Hz, 1H), 7.45(d, J=1.8Hz, 1H), 7.59(d,



J=8.4Hz, 1H), 7.68(d, J=8.7Hz, 2H)


I-101
m.p. 103–105° C.



1HNMR(CDCl3)δ 2.18(dd, J=1.5, 1.2Hz, 3H), 3.45(s, 3H), 3.74(s,



3H), 4.79(dd, J=5.7, 1.2Hz, 2H), 5.81(dt, J=5.7, 1.5Hz, 2H),



6.45(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.95(s, 1H), 6.96(s, 1H),



7.07(s, 1H), 7.52(d, J=8.7Hz, 2H)



IR(KBr)3527, 3328, 2930, 1614, 1593, 1523, 1492, 1463, 1408,



1262, 1235, 1225, 1119, 1072, 1010, 828, 805 cm−1

















TABLE 29







I-102
m.p. 95–99° C.



1HNMR(CDCl3)δ 3.45(s, 3H), 3.74(s, 3H), 4.67(s, 2H), 5.47(m,



1H), 5.55(dd, J=2.7, 1.2Hz, 1H), 6.45(s, 1H), 6.92(d, J=8.7Hz,



2H), 7.01(m, 2H), 7.04(d, J=1.8Hz, 1H), 7.53(d, J=8.7Hz, 2H)


I-103
1HNMR(CDCl3)δ 3.45(s, 3H), 3.75(s, 3H), 4.59(d, J=4.2Hz, 2H),



6.45(s, 1H), 6.45(m, 1H), 6.55(d, J=12.9Hz, 1H), 6.92(d, J=8.7Hz,



2H), 6.96(brs, 2H), 7.08(brs, 1H), 7.53(d, J=8.7Hz, 2H)


I-104
1HNMR(CDCl3)δ 3.45(s, 3H), 3.75(s, 3H), 4.64(dd,



J=6.0 and 1.2Hz, 2H), 6.23(dt, J=13.2 and 6.0Hz, 1H), 6.42(dt,



J=13.2 and 1.2Hz, 1H), 6.45(s, 1H), 6.91(d, J=8.7Hz, 2H),



6.96(brs, 2H), 7.08(brs, 1H), 7.58(d, J=8.7Hz, 2H)


I-105
1HNMR(CDCl3)δ 3.46(s, 3H), 3.75(s, 3H), 3.98(d-like, J=7.2Hz,



1H), 4.64(d-like, J=3.9Hz, 1H), 6.04(dt, J=15.3, 4.8Hz, 1H),



6.06(1H, dt, J=15.3, 6.0Hz, 1H), 6.45(s, 1H), 6.92(d, J=8.7Hz,



2H), 6.95(s, 1H), 7.08(s, 2H), 7.53(d, J=8.7Hz, 2H)


I-106
foam



1HNMR(CDCl3)δ 1.76(s, 3H), 1.83(s, 3H), 2.08(s, 3H), 3.36(s,



3H), 3.71(s, 3H), 4.61(d, J=7.0Hz, 2H), 4.94(s, 1H), 5.54(t,



J=7.0Hz, 1H), 5.70(s, 1H), 6.70(dd, J=8.4, 2.0Hz, 1H), 6.74(s,



1H), 6.84(d, J=2.0Hz, 1H)



IR(KBr)3410, 1520, 1476, 1390, 1243, 1225, 1101, 1084, 834,



812, 775 cm−1


I-107
m.p. 112–114° C.



1HNMR(CDCl3)δ 3.03(s, 3H), 3.57(s, 3H), 3.74(s, 3H), 3.87(s,



3H), 4.90(S, 2H), 5.15(s, 2H), 5.63(brs, 1H), 6.68(s, 1H),



6.91–7.07(m, 5H), 7.38–7.51(m, 5H), 7.53(m, 2H)



IR(KBr)3512, 2952, 2936, 1607, 1519, 1468, 1442, 1382, 1284,



1253, 1229, 1215, 1185, 1156, 1112, 1079, 1064, 1020, 983, 956,



914, 831 cm−1


I-108
1HNMR(CDCl3)δ 2.20(d, J=1.2Hz, 3H), 2.76(s, 3H), 3.22(s, 3H),



3.24(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 4.65(m, 2H), 5.96(m, 1H),



7.07(d, J=8.4Hz, 1H), 7.34–7.41(m, 4H), 7.68(m, 2H)

















TABLE 30







I-109
m.p. 153–154° C.



1HNMR(CDCl3)δ 2.20(d, J=1.5Hz, 3H), 2.75(s, 3H), 3.21(s,



3H), 3.23(s, 3H), 3.56(2, 3H), 3.78(s, 3H), 4.81(m, 2H), 5.80



(m, 1H), 6.84(s, 1H), 7.10(d, J=8.1Hz, 1H), 7.34–7.41(m,



4H), 7.68(m, 2H)



IR(KBr)1519, 1481, 1390, 1364, 1234, 1177, 1150, 1119,



1077, 1011, 969, 945, 876, 816, 799, 521 cm−1


I-110
1HNMR(CDCl3)δ 2.68(s, 3H), 3.11(s, 3H), 3.21(s, 3H), 3.56



(s, 3H), 3.78(s, 3H), 3.83(s, 3H), 5.11(s, 2H), 6.84(s,



1H), 6.93(d, J=8.7Hz, 2H), 7.16(d, J=8.7Hz, 1H), 7.35(dd,



J=8.7, 2.1Hz, 1H), 7.36–7.40(m, 5H), 7.68(d, J=8.7Hz, 2H)


I-111
1HNMR(CDCl3)δ 2.78(s, 3H), 3.22(s, 6H), 3.55(s, 3H),



3.78(s, 3H), 5.23(s, 2H), 6.85(s, 1H), 7.08(d, J=8.7Hz,



1H), 7.34(dd, J=8.7, 2.1Hz, 1H), 7.39(d, J=8.7Hz, 2H),



7.42(d, J=2.1Hz, 1H), 7.44(brs, 2H), 7.68(d, J=8.7Hz,



2H), 8.70(brs, 2H)


I-112
1HNMR(CDCl3)δ 2.70(s, 3H), 3.21(s, 3H), 3.24(s, 3H),



3.55(s, 3H), 3.78(s, 3H), 5.33(s, 2H), 6.84(s, 1H), 7.15(d,



J=8.4Hz, 1H), 7.27(dd, J=7.5, 4.2Hz, 1H), 7.33(dd, J=



8.4, 2.4Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.42(d, J=2.4Hz, 1H),



7.62(brd, J=7.5Hz, 1H), 7.68(d, J=8.7Hz, 2H), 7.76(ddd, J=



7.5, 7.5, 1.8Hz, 1H), 8.61(d, J=4.2Hz, 1H)


I-113
1HNMR(CDCl3)δ 2.76(s, 3H), 3.15(s, 3H), 3.21(s, 3H),



3.55(s, 3H), 3.78(s, 3H), 5.22(s, 2H), 6.85(s, 1H), 7.17(d, J=



8.4Hz, 1H), 7.38(dd, J=8.4, 2.1Hz, 1H), 7.38(m, 1H), 7.39(d,



J=8.7Hz, 2H), 7.42(d, J=2.1Hz, 1H), 7.68(d, J=8.7Hz,



2H), 7.88(d, J=7.8Hz, 1H), 7.64(brs, 1H), 8.73(brs, 1H)


I-114
1HNMR(CDCl3)δ 3.45(s, 3H), 3.74(s, 3H), 5.10(s,



2H), 6.45(s, 1H), 6.91(d, J=8.7Hz, 2H), 6.95(dd, J=8.4,



2.1Hz, 1H), 7.03(d, J=8.4Hz, 1H), 7.08(d, J=2.1Hz, 1H),



7.23(brd, J=7.8Hz, 2H), 7.34(brd, J=7.8Hz, 2H), 7.53(d,



J=8.7Hz, 2H)



IR(Nujol)3464, 3344, 1611, 1581, 1523, 1490, 1266, 1113,



1073, 1011, 1000, 821, 782 cm−1


I-115
1HNMR(CDCl3)δ 3.45(s, 3H), 3.75(s, 3H), 5.11(s, 2H),



6.45(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.96(dd, J=8.4, 2.1Hz,



1H), 7.01(d, J=8.4Hz, 1H), 7.09(d, J=2.1Hz, 1H), 7.11(dd,



J=8.7, 8.7Hz, 2H), 7.42(dd, J=8.7, 5.4Hz, 2H), 7.54(d,



J=8.7Hz, 2H)



IR(Nujol)3560, 3400, 1612, 1589, 1522, 1492, 1260, 1225,



1116, 1068, 1006, 992, 841, 826, 803, 786 cm−1

















TABLE 31







I-116
1HNMR(CDCl3)δ 3.45(s, 3H), 3.75(s, 3H), 5.23(s, 2H), 6.45



(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.97(brs, 2H), 7.11(brs, 1H)



7.31(dd, J=8.4, 2.1Hz, 1H), 7.46(d, J=8.4Hz, 1H), 7.47(d,



J=2.1Hz, 1H), 7.54(d, J=8.7Hz, 2H)



IR(Nujol)3460, 3359, 1610, 1594, 1522, 1490, 1264, 1164,



1110, 1072, 1008, 877, 824, 781 cm−1


I-117
1HNMR(CDCl3)δ 3.45(s, 3H), 3.75(s, 3H), 3.84(s, 3H),



5.07(s, 2H), 6.45(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.95(d, J=9.0Hz,



2H), 6.96(dd, J=8.4, 1.8Hz, 1H), 7.04(d, J=8.4Hz, 1H), 7.08(d,



J=1.8Hz, 1H), 7.37(d, J=8.7Hz, 2H), 7.53(d, J=9.0Hz, 2H)



IR(Nujol)3400, 1612, 1586, 1516, 1488, 1246, 1174, 1113,



1070, 1011, 823 cm−1


I-118
1HNMR(DMSO-d6)δ 3.29(s, 3H), 3.64(s, 3H), 5.20(s,



2H), 6.39(s, 1H), 6.64(dd, J=8.4, 2.1Hz, 1H), 6.79(d, J=



2.1Hz, 1H), 6.84(d, J=8.7Hz, 2H), 6.92(d, J=8.4Hz, 1H), 7.43



(d, J=8.7Hz, 2H), 7.52(d, J=6.0Hz, 2H), 8.59(d, J=6.0Hz, 2H)



IR(Nujol)3473, 3441, 1610, 1582, 1523, 1493, 1404, 1241,



1112, 1074, 1005, 816, 782 cm−1


I-119
1HNMR(CDCl3)δ 3.45(s, 3H), 3.74(s, 3H), 5.27(s, 2H),



6.45(s, 1H), 6.92(dd, J=8.4, 1.8Hz, 1H), 6.93(d, J=8.7Hz,



2H), 7.11(d, J=8.4Hz, 1H), 7.12(d, J=1.8Hz, 1H), 7.31(m, 1H),



7.36(brd, J=7.5Hz, 1H), 7.53(d, J=8.7Hz, 2H), 7.77(ddd,



J=7.5, 7.5, 1.8Hz, 1H), 8.66(d, J=5.0Hz, 1H)



IR(Nujol)3555, 3467, 3342, 1608, 1597, 1586, 1522, 1466,



1210, 1117, 1080, 1016, 822, 761 cm−1


I-120
1HNMR(CDCl3)δ 3.45(s, 3H), 3.74(s, 3H), 5.21(s, 2H), 6.46(s,



1H), 6.91(d, J=8.7Hz, 2H), 6.99(brs, 2H), 7.11(brs, 1H), 7.40



(dd, J=7.5, 5.0Hz, 1H), 7.53(d, J=8.7Hz, 2H), 7.83(d, J=7.5Hz,



1H), 8.64(brd, J=5.0Hz, 1H), 8.74(brs, 1H)



IR(Nujol)3342, 1609, 1586, 1522, 1489, 1253, 1118, 1074,



1010, 827, 782 cm−1


I-121
m.p. 166–168° C.



1HNMR(CDCl3)δ 3.45(s, 3H), 3.75(s, 3H), 4.77(d, J=6.3Hz,



2H), 6.22(t, J=6.3Hz, 1H), 6.93(d, J=8.7Hz, 2H), 6.93(d, J=



8.7Hz, 1H), 6.98(dd, J=8.7, 1.8Hz, 1H), 7.08(d, J=1.8Hz, 1H),



7.53(d, J=8.7Hz, 2H)



IR(KBr)3474, 3411, 2957, 2930, 1615, 1589, 1569, 1523, 1492,



1407, 1286, 1263, 1230, 1113, 1070, 825 cm−1

















TABLE 32







I-122
m.p. 190–192° C.



1HNMR(CDCl3)δ 2.56(s, 3H), 3.22(s, 3H), 3.56(s, 3H), 3.79(s,



3H), 5.17(s, 2H), 5.73(s, 1H), 6.84(s, 1H), 6.93(dd, J=8.1 and



1.9Hz, 1H), 7.02(d, J=8.1Hz, 1H), 7.05(d, J=1.9Hz, 1H),



7.37–7.45(m, 1H), 7.71(d, J=8.6Hz, 2H)



IR(KBr)3512, 1519, 1484, 1367, 1174, 1150, 1078, 957,



870, 798 cm−1


I-123
foam



1HNMR(CDCl3)δ 3.08(s, 3H), 3.21(s, 3H), 3.44(s, 3H), 3.78(s,



3H), 5.15(s, 2H), 6.95(s, 1H), 7.11(d, J=8.7Hz, 1H), 7.33–



7.47(m, 9H), 7.71(d, J=8.7Hz, 2H), 13.3–14.5(brs, 1H)



IR(KBr): 3422, 1735, 1702, 1520, 1471, 1366, 1175, 1150,



1118, 971, 954, 863, 807 cm−1


I-124
m.p. 258–259° C.(dec)



1HNMR(DMSO-d6)δ 3.32(s, 3H), 3.69(s, 3H), 5.10(2H, s),



6.65(dd, J=8.4, 2.1Hz, 1H), 6.79(d, J=2.1Hz, 1H), 6.86(d,



J=8.4Hz, 2H), 6.90(s, 1H), 6.94(d, J=8.4Hz, 1H), 7.30–7.54



(m, 7H), 8.98(s, 1H), 9.63(s, 1H)



IR(KBr): 3437, 3157, 1702, 1610, 1590, 1521, 1474, 1464,



1379, 1260, 1245, 1224, 1061, 1014, 952, 834, 793,



748, 698 cm−1


I-125
1HNMR(CDCl3)δ 1.75(s, 3H), 1.81(s, 3H), 3.21(s, 3H),



3.41(s, 3H), 3.68(s, 3H), 3.77(s, 3H), 4.61(d, J=6.8Hz,



2H), 5.50(t, J=6.8Hz, 1H), 6.93(s, 1H), 7.02(d, J=8.5Hz,



1H), 7.27(d, J=8.5, 2.3Hz, 1H), 7.33(dd, J=2.3Hz, 1H),



7.38(d, J=8.6Hz, 2H), 7.71(d, J=8.6Hz, 2H)


I-126
1HNMR(CDCl3)δ 1.75(s, 3H), 1.81(s, 3H), 3.41(s, 3H),



3.65(s, 3H), 3.76(s, 3H), 4.59(d, J=6.6Hz, 2H), 5.06(s, 1H),



5.51(t, J=6.6Hz, 1H), 5.67(s, 1H), 6.83(dd, J=8.4, 2.1Hz,



1H), 6.87(s, 1H), 6.90–6.93(m, 3H), 6.98(d, J=2.1Hz, 1H)



7.54(d, J=9.0Hz, 2H)


I-127
m.p. 116–117° C.



1HNMR(DMSO-d6)δ 1.72(s, 3H), 1.76(s, 3H), 3.32(s,



3H), 3.70(s, 3H), 4.53(d, J=7.1Hz, 2H), 5.48(t, J=7.1Hz, 1H),



6.65(dd, J=8.4, 2.1Hz, 1H), 6.73(d, J=2.1Hz, 1H), 6.86(d, J=



8.6Hz, 2H), 6.88(d, J=8.4Hz, 1H), 6.93(s, 1H), 7.47(d, J=



8.6Hz, 2H), 8.84(s, 1H), 9.62(s, 1H), 11.9–13.4(brs, 1H)



IR(KBr): 3446, 1703, 1611, 1593, 1520, 1471, 1380, 1260,



1225, 1081, 997, 952, 838 cm−1

















TABLE 33







I-128
oil



1HNMR(CDCl3)δ 1.65(s, 3H), 1.78(s, 3H), 2.96(s, 3H), 3.22(s,



3H), 3.25(s, 3H)3.55(s, 3H), 3.79(s, 3H), 4.77(d, J=7.8Hz, 2H),



5.53(t, J=7.8Hz, 1H), 6.87(s, 1H), 7.39&7.67(ABq, J=8.7Hz,



4H), 7.70(d, J=2.1Hz, 1H), 7.86(d, J=2.1Hz, 1H), 10.36(s, 1H)



IR(CHCL3)1691, 1473, 1374, 1230, 1226, 1209, 1178, 1152,



1086, 969, 874, 805 cm−1


I-129
oil



1HNMR(CDCl3)δ 1.73(d, J=0.9Hz, 3H), 1.80(s, 3H), 2.89(s,



3H), 3.20(s, 3H), 3.22(s, 3H), 3.54(s, 3H), 3.79(s, 3H), 4.66(d,



J=7.8Hz, 2H), 4.77(s, 2H), 5.55(m, 1H), 6.85(s, 1H),



7.39&7.68(ABq, J=9.0Hz, 4H), 7.39(d, J=2.1Hz, 1H), 7.44(d,



J=2.1Hz, 1H)



IR(CHCl3)1475, 1372, 1230, 1178, 1151, 1085, 969, 874 cm−1


I-130
m.p. 189–190° C.



1HNMR(CDCl3)δ 1.36(s, 9H), 2.81(s, 3H), 3.22(s, 3H), 3.30(s,



3H), 3.56(s, 3H), 3.79(s, 3H), 6.86(s, 1H), 7.36–7.42(m, 3H),



7.54(d, J=1.8Hz, 1H), 7.67–7.72(m, 3H)



IR(KBr)1472, 1363, 1331, 1179, 1153, 1082, 961, 950, 877, 846,



817, 791, 526 cm−1


I-131
m.p. 147–148° C.



1HNMR(CDCl3)δ 2.95(s, 3H), 3.18(s, 3H), 3.22(s, 3H), 3.55(s,



3H), 3.79(s, 3H), 5.28(s, 2H), 6.86(s, 1H), 7.38–7.44(m, 7H),



7.67(m, 2H), 7.75(d, J=2.1Hz, 1H), 7.83(d, J=2.1Hz, 1H)



IR(KBr)1687, 1512, 1472, 1365, 1352, 1234, 1201, 1180, 1151,



1082, 971, 947, 870, 846, 810, 794, 703, 523 cm−1


I-132
m.p. 122–124° C.



1HNMR(CDCl3)δ 1.68(s, 3H), 1.74(s, 3H), 2.80(s, 3H), 3.22(s,



3H), 3.28(s, 3H), 3.56(s, 3H), 3.62(d, J=7.8Hz, 2H), 3.78(s,



3H), 5.31(m, 1H), 6.85(s, 1H), 7.34(dd, J=8.1Hz, J=1.8Hz, 1H),



7.39&7.68(ABq, J=8.7Hz, 4H), 7.43(d, J=8.1Hz, 1H), 7.46(d,



J=1.8Hz, 1H)



IR(KBr)1474, 1362, 1180, 1151, 1076, 1014, 968, 944, 870, 816,



799, 521 cm−1


I-133
1HNMR(CDCl3)δ 1.73(d, J=0.9Hz, 3H), 1.82(s, 3H), 3.44(s,



3H), 3.75(s, 3H), 4.54(d, J=6.9Hz, 2H), 4.78(s, 2H), 5.30(s,



1H), 5.61(m, 1H), 5.67(s, 1H), 6.01(s, 1H), 6.45(s, 1H),



6.92&7.52(ABq, J=8.7Hz, 4H), 7.02(d, J=2.1Hz, 1H), 7.05(d,



J=2.1Hz, 1H)



IR(KBr)3428, 1612, 1522, 1483, 1458, 1403, 1362, 1334, 1304,



1266, 1226, 1174, 1116, 1083, 1024, 970, 938 cm−1

















TABLE 34







I-134
m.p. 167–168° C.



1HNMR(CDCl3)δ 1.39(d, J=1.2Hz, 3H), 1.70(s, 3H), 3.36(d,



J=8.1Hz, 2H), 3.45(s, 3H), 3.74(s, 3H), 4.98(s, 1H), 5.29(m, 1H),



5.96(s, 1H), 6.45(s, 1H), 6.78(s, 1H), 6.93&7.54(ABq, J=8.7Hz,



4H), 6.96(dd, J=7.8Hz, J=1.8Hz, 1H), 7.09(d, J=1.8Hz, 1H),



7.49(d, J=7.8Hz, 1H)



IR(KBr)3413, 3365, 2931, 1611, 1552, 1520, 1502, 1475, 1455,



1441, 1402, 1360, 1323, 1262, 1227, 1206, 1182, 1170, 1162,



1114, 1100, 1081, 1052, 1014, 941, 835, 816, 587, 542 cm−1


I-135
m.p. 183–184° C.



1HNMR(CDCl3)δ 3.46(s, 3H), 3.74(s, 3H), 3.83(s, 3H), 4.78(m,



2H), 5.99(m, 1H), 6.44(m, 1H), 6.45(s, 1H), 6.92(d, J=8.7Hz, 2H),



6.94(dd, J=8.1, 1.8Hz, 1H), 7.00(d, J=8.1Hz, 1H), 7.10(d,



J=1.8Hz, 1H), 7.53(d, J=8.7Hz, 2H)



IR(KBr)3383, 2929, 1699, 1523, 1491, 1405, 1262, 1236, 1206,



1173, 1116, 1071, 1011, 822 cm−1


I-136
1HNMR(CD3OD)δ 1.26(s, 3H), 1.29(s, 3H), 3.38(s, 3H), 3.68(s,



3H), 3.80(dd, J=8.4, 2.7Hz, 1H), 3.96(dd, J=9.6, 8.4Hz, 1H),



4.34(dd, J=9.6, 2.7Hz, 1H), 6.44(s, 1H), 6.80(dd, J=8.1, 1.8Hz,



1H), 6.85(d, J=8.7Hz, 2H), 6.86(d, J=1.8Hz, 1H), 7.96(d, J=8.1Hz,



1H), 7.46(d, J=8.7Hz, 2H)



IR(Nujol)3367, 1612, 1588, 1523, 1489, 1254, 1226, 1115, 1072,



1013, 940, 814 cm−1


I-137
1HNMR(CD3OD)δ 3.38(s, 3H), 3.68(s, 3H), 4.02(dd, J=11.0,



3.6Hz, 1H), 4.12(dd, J=11.0, 1.8Hz, 1H), 5.48(dd, J=3.6, 1.8Hz,



1H), 6.43(s, 1H), 6.83–6.87(m, 3H), 6.85(d, J=8.7Hz, 2H), 7.46(d,



J=8.7Hz, 2H)



IR(Nujol)3410, 1612, 1588, 1522, 1487, 1269, 1231, 1114, 1071,



1011, 947, 824 cm−1


I-138
1HNMR(CD3OD)δ 3.38(s, 3H), 3.68(s, 3H), 4.70(d, J=5.4Hz, 2H),



6.43(s, 1H), 6.80(dd, J=8.1, 2.1Hz, 1H), 6.85(d, J=8.4Hz, 2H),



6.88(d, J=2.1Hz, 1H), 6.98(d, J=8.1Hz, 1H), 7.46(d, J=8.4Hz, 2H),



7.62(t, J=5.4Hz, 1H)



IR(Nujol)3368, 1612, 1589, 1523, 1489, 1253, 1226, 1114, 1072,



1011, 940, 825 cm−1


I-139
1HNMR(CDCl3)δ 3.45(s, 3H), 3.74(s, 3H), 3.92(s, 3H), 4.75(d,



J=5.1Hz, 2H), 6.45(s, 1H), 6.91(d, J=8.7Hz, 2H), 6.92(d, J=6.0Hz,



1H), 7.00(dd, J=6.0, 1.8Hz, 1H), 7.09(d, J=1.8Hz, 1H), 7.52(d,



J=8.7Hz, 2H), 7.58(t, J=5.1Hz, 1H)



IR(Nujol)3399, 1612, 1589, 1523, 1489, 1252, 1226, 1115, 1072,



1043, 1014, 941, 825 cm−1

















TABLE 35







I-140
1HNMR(CD3OD)δ 3.38(s, 3H), 3.68(s, 3H), 4.51(s, 2H), 4.71(d,



J=5.4Hz, 2H), 6.43(s, 1H), 6.80(dd, J=8.4, 2.1Hz, 1H), 6.85(d,



J=8.4Hz, 2H), 6.87(d, J=2.1Hz, 1H), 6.98(d, J=8.4Hz, 1H), 7.46(d,



J=8.4Hz, 2H), 7.75(t, J=5.4Hz, 1H)



IR(Nujol)3384, 1611, 1588, 1523, 1489, 1252, 1227, 1115, 1072,



1014, 824, 758 cm−1


I-141
1HNMR(CDCl3)δ 3.45(s, 3H), 3.74(s, 3H), 4.76(d, J=5.1Hz, 2H),



5.15(s, 2H), 6.45(s, 1H), 6.86(d, J=8.4Hz, 1H), 6.92(d, J=8.7Hz,



2H), 6.94(dd, J=8.4, 2.1Hz, 1H), 7.08(d, J=2.1Hz, 1H),



7.31–7.40(m, 5H), 7.53(d, J=8.7Hz, 2H), 7.65(t, J=5.1Hz, 1H)



IR(Nujol)3399, 1611, 1588, 1523, 1489, 1251, 1225, 1115, 1072,



1013, 940, 825 cm−1


I-142
1HNMR(CDCl3—CD3OD1:1)δ 3.26(s, 3H), 2.64(m, 4H), 3.13(m,



4H), 3.44(s, 3H), 3.73(s, 3H), 4.78(d, J=4.5Hz, 2H), 6.45(s, 1H),



6.90(d, J=8.7Hz, 2H), 6.90(dd, J=8.4, 2.1Hz, 1H), 6.99(d,



J=2.1Hz, 1H), 7.00(d, J=8.4Hz, 1H), 7.12(t, J=4.5Hz, 1H), 7.49(d,



J=8.7Hz, 2H)



IR(Nujol)3492, 3297, 1607, 1561, 1523, 1486, 1247, 1224, 1113,



1011, 957, 828, 799 cm−1


I-143
1HNMR(CDCl3)δ 3.09(m, 4H), 3.45(s, 3H), 3.74(s, 3H), 3.86(m,



4H), 4.82(d, J=4.2Hz, 2H), 6.44(s, 1H), 6.92(d, J=8.7Hz, 2H),



6.98(dd, J=8.4, 1.8Hz, 1H), 7.00(t, J=4.2Hz, 1H), 7.04(d,



J=8.4Hz, 1H), 7.07(d, J=1.8Hz, 1H), 7.53(d, J=8.7Hz, 2H)



IR(Nujol)3366, 1611, 1586, 1523, 1488, 1268, 1227, 1114, 1070,



1011, 823 cm−1


I-144
1HNMR(CDCl3)δ 1.29(t, J=6.9Hz, 3H), 2.65(dd, J=15.9, 6.6Hz,



1H), 2.81(dd, J=15.9, 6.6Hz, 1H), 3.44(s, 3H), 3.75(s, 3H),



4.03(dd, J=11.4, 6.9Hz, 1H), 4.20(q, J=6.9Hz, 2H), 4.35(dd,



J=11.4, 2.4Hz, 1H), 4.66(ddt, J=6.9, 6.6, 2.4Hz, 1H), 6.44(s, 1H),



6.92(d, J=8.7Hz, 2H), 6.96–7.01(m, 3H), 7.53(d, J=8.7Hz, 2H)


I-145
oil



1HNMR(CDCl3)δ 1.68(s, 3H), 1.74(d, J=0.9Hz, 3H), 2.55(m, 2H),



3.44(s, 3H), 3.75(s, 3H), 4.04(t, J=7.2Hz, 2H), 4.97(brs, 1H),



5.23(m, 1H), 6.00(s, 1H), 6.45(s, 1H), 6.92&7.53(ABq, J=8.7Hz,



4H), 7.02(m, 1H), 7.17–7.22(m, 2H)



IR(KBr)1613, 1525, 1490, 1475, 1463, 1454, 1402, 1304, 1269,



1231, 1112, 1072, 1019, 827 cm−1

















TABLE 36







I-146
m.p. 256–257° C.



1HNMR(DMSO-d6)δ 3.35(s, 3H), 3.44(s, 3H), 3.74(s, 3H), 5.22



(s, 2H), 7.06(s, 1H), 7.28–7.56(m, 11H), 7.69(s, 1H), 7.76



(d, J=8.6Hz, 2H)



IR(KBr): 3479, 3360, 1672, 1517, 1465, 1361, 1339, 1295,



1261, 1228, 1172, 1144, 1118, 1013, 957, 870, 852,



804, 751 cm−1


I-147
m.p. 163–164° C.



1HNMR(CDCl3)δ 1.74(s, 3H), 1.81(s, 3H), 3.43(s, 3H), 3.74(s,



3H), 4.58(d, J=6.8Hz, 2H), 5.50(t, J=6.8Hz, 1H), 5.80(s,



1H), 6.37(s, 1H), 6.86–6.95(m, 5H), 6.90(d, J=8.6Hz, 2H),



6.99(s, 1H), 7.49(d, J=8.6Hz, 2H)



IR(KBr): 3533, 3412, 3350, 1655, 1609, 1588, 1519, 1469,



1373, 1274, 1245, 1227, 1131, 1082, 1060, 999,



954, 838 cm−1


I-148
1HNMR(CDCl3)δ 2.88(s, 3H), 3.22(s, 3H), 3.54(s, 3H),



3.77(s, 3H), 5.35(m, 2H), 6.85(s, 1H), 7.24(d, J=9.0Hz,



1H), 7.39(d, J=8.7Hz, 2H), 7.42–7.46(m, 5H), 7.65(d.d,



J=9.0&2.1Hz, 1H), 7.68(d, J=8.7Hz, 2H), 8.26(d,



J=2.1Hz, 1H)


I-149
1HNMR(CDCl3)δ 1.80(s, 3H), 1.85(s, 3H), 3.43(s, 3H), 3.74(s,



3H), 4.80(d, J=6.9Hz, 2H), 5.76(t, J=6.9Hz, 1H), 6.46(s, 1H),



6.92(d, J=8.4Hz, 2H), 7.14(d, J=8.7Hz, 1H), 7.49(d, J=8.4Hz,



2H), 7.70(d.d, J=8.7&2.1Hz, 1H), 8.28(d, J=2.1Hz, 1H)



IR(KBr)3472, 1707, 1671, 1610, 1520, 1482, 1460, 1426,



1269, 1226, 1119, 1076, 1012 cm−1


I-150
1HNMR(CDCl3)δ 1.76(s, 3H), 1.81(s, 3H), 2.63(s, 3H), 3.21(s,



3H), 3.55(s, 3H), 3.77(s, 3H), 4.62(d, J=6.3Hz, 2H), 4.73(s,



2H), 5.50(t, J=6.3Hz, 1H), 6.84(s, 1H), 6.99(d, J=9.0Hz,



1H), 7.51–7.42(m, 9H), 7.70(d, J=9.0Hz, 2H)



IR(KBr)3432, 1607, 1512, 1479, 1364, 1234, 1176, 1151,



1079, 1016 cm−1


I-151
1HNMR(CDCl3)δ 1.58(s, 3H), 1.81(s, 3H), 3.45(s, 3H), 3.73(s,



3H), 4.61(d, J=6.6Hz, 2H), 4.72(s, 2H), 5.52(t, J=6.6Hz,



1H), 6.45(s, 1H), 6.91 (d, J=8.7Hz, 2H), 6.98(d, J=8.4Hz,



1H), 7.36(d.d, J=8.4&2.1Hz, 1H), 7.38(d, J=2.1Hz, 1H),



7.50(d, J=8.4Hz, 2H)



IR(KBr)3580, 3411, 1611, 1521, 1485, 1464, 1397, 1233,



1113, 1077, 1024, 1001 cm−1


I-152
1HNMR(CDCl3)δ 3.50(s, 3H), 3.77(s, 3H), 5.15(s, 2H), 5.72(s,



1H), 6.03(s, 2H), 6.71(d.d, J=8.4&2.1Hz, 1H), 6.91(d, J=



8.4Hz, 1H), 6.97(s, 1H), 6.98(d, J=8.4Hz, 1H), 7.07(s, 1H),



7.09(d.d, J=8.4&2.1Hz, 1H), 7.16(d, J=2.1Hz, 1H), 



7.34–7.50(m, 5H), 9.89(s, 1H)



IR(KBr)3446, 1697, 1587, 1511, 1470, 1383, 1285, 1240,



1127, 1036 cm−1

















TABLE 37







1-153
1HNMR(CDCl3)δ 3.78(s, 3H), 3.79(s, 3H), 4.87(s, 1H), 5.16(s,



2H), 5.70(s, 1H), 6.88–6.91(m, 2H), 6.97(s, 1H), 7.00(s, 1H),



6.99(d, J=8.4Hz, 1H), 7.08(dd, J=2.1, 8.4Hz, 1H), 7.23(d,



J=2.1Hz, 1H), 7.34–7.49(m, 7H)


I-154
1HNMR(CDCl3)δ 1.69(s, 3H), 1.74(s, 3H), 2.51–2.58(m, 2H),



3.19(s, 3H), 3.21(s, 3H), 3.79(s, 3H), 3.80(s, 3H), 4.07(t, J=6.9Hz,



2H), 5.18–5.27(m, 1H), 6.92(s, 1H), 6.95(s, 1H), 7.05(d,



J=8.7Hz, 1H), 7.32–7.37(m, 2H), 7.49(dd, J=2.1, 8.7Hz, 1H),



7.58(d, J=2.1Hz, 1H), 7.60–7.64(m, 2H)


1-155
1HNMR(CDCl3)δ 1.69(s, 3H), 1.75(s, 3H), 2.53(q, J=6.9Hz,



2H), 3.77(s, 3H), 3.78(s, 3H), 4.07(t, J=6.9Hz, 2H), 4.97(s, 3H),



5.20–5.25(m, 1H), 5.71(s, 1H), 6.87–6.93(m, 3H), 7.07(dd, J=1.8,



8.4Hz, 1H), 7.20(d, J=1.8Hz, 1H), 7.45–7.50(m, 2H)


I-156
m.p. 163–175° C.



1HNMR(CDCl3)δ 2.76(s, 3H), 3.19(s, 3H), 3.22(s, 3H), 3.54(s,



3H), 3.79(s, 3H), 5.20(s, 2H), 5.68(s, 1H), 6.84(s, 1H), 6.97(d,



J=1.8Hz, 1H), 6.99(d, J=1.8Hz, 1H), 7.37–7.47(m, 7H),



7.68(m, 2H)



IR(KBr)3436, 1480, 1415, 1391, 1363, 1233, 1178, 1151, 1079,



1024, 969, 953, 875, 801, 522 cm−1


I-157
m.p. 176–178° C.



1HNMR(CDCl3)δ 2.08(s, 3H), 2.40, (s, 3H), 2.72(s, 3H), 3.21(s,



3H), 3.22(s, 3H), 3.55(s, 3H), 3.79(s, 3H), 5.13(s, 2H), 6.86(s,



1H), 7.39and7.68(ABq, J=8.7Hz, 4H), 7.47(d, J=2.1Hz, 1H),



7.49(d, J=2.1Hz, 1H)



IR(KBr)1770, 1747, 1477, 1391, 1366, 1235, 1180, 1152, 1077,



873, 799, 522 cm−1


I-158
m.p. 175–177° C.



1HNMR(CDCl3)δ 2.87(s, 3H), 3.13(s, 6H), 3.22(s, 3H), 3.55(s,



3H), 3.81(s, 3H), 5.22(s, 2H), 6.86(s, 1H), 7.38–7.45(m, 7H),



7.51–7.53(m, 2H), 7.67(m, 2H)



IR(KBr)1479, 1367, 1180, 1151, 1080, 1019, 966, 876, 798,



525 cm−1

















TABLE 38







I-159
foam



1HNMR(CDCl3)δ 2.44(s, 3H), 3.21(s, 3H), 3.54(s, 3H), 3.76(s,



3H), 3.79(s, 3H), 4.77(s, 2H), 5.24(s, 2H), 6.83(s, 1H),



6.90–7.00(m, 3H), 7.30–7.48(m, 5H), 7.37(d, J=8.8Hz, 2H),



7.69(d, J=8.8Hz, 2H)



IR(KBr):1758, 1519, 1481, 1365, 1236, 1176, 1150, 1079, 1013,



963, 872, 798 cm−1


I-160
m.p. 146–147° C.



1HNMR(DMSO-d6)δ 3.31(s, 3H), 3.65(s, 3H), 4.63(s, 2H), 5.15(s,



2H), 6.40(s, 1H), 6.83–6.90(m, 4H), 7.05(d, J=8.4Hz, 1H),



7.32–7.52(m, 7H), 8.57(s, 1H), 9.50(s, 1H), 12.0–13.9(brs, 1H)



IR(KBr):3422, 1728, 1611, 1524, 1489, 1455, 1405, 1247, 1142,



1118, 1080, 1012, 818, 749, 742, 698 cm−1


I-161
1HNMR(CDCl3)δ 1.76(s, 3H), 1.79(s, 3H), 2.57(s, 3H), 3.21(s,



3H), 3.56(s, 3H), 3.77(s, 3H), 3.80(s, 3H), 4.64(d, J=6.5Hz,



2H), 4.74(s, 2H), 5.54(t, J=6.5Hz, 1H), 6.83(s, 1H), 6.88(d,



J=1.5Hz, 1H), 7.02–7.03(m, 2H), 7.38(d, J=8.7Hz, 2H), 7.69(d,



J=8.7Hz, 2H)


I-162
m.p. 147–149° C.



1HNMR(DMSO-d6)δ 1.73(s, 3H), 1.77(s, 3H), 3.30(s, 3H), 3.65(s,



3H), 4.57(d, J=6.6Hz, 2H), 4.60(s, 2H), 5.86(t, J=6.6Hz, 1H),



6.40(s, 1H), 6.80(d, J=1.7Hz, 1H), 6.84(d, J=8.7Hz, 2H), 6.87(dd,



J=8.7Hz, 1H), 6.99(d, J=8.7Hz, 1H), 7.43(d, J=8.7Hz, 2H), 8.56(s,



1H), 9.51(s, 1H), 12.8(brs, 1H)



IR(KBr):3483, 3376, 1737, 1612, 1523, 1489, 1460, 1397, 1271,



1231, 1175, 1120, 1072, 1012, 904, 820 cm−1


I-162
m.p. 144–145° C.



1HNMR(CDCl3)δ 3.04(s, 3H), 3.20(s, 3H), 3.59(s, 3H), 3.75(s,



3H), 4.90(s, 2H), 5.16(s, 2H), 5.65(s, 1H), 6.67(s, 1H), 6.92(dd,



J=2.1, 8.4Hz, 1H), 7.00(d, J=8.4Hz, 1H), 7.06(d, J=2.1Hz, 1H),



7.26–7.47(m, 7H), 7.61–7.66(m, 2H)



IR(KBr)3600–3200(br), 1517, 1477, 1449, 1382, 1361, 1277,



1235, 1199, 1150, 1112, 1079, 1064, 1010, 997 cm−1


I-164
m.p. 80–83° C.



1HNMR(CDCl3)δ 2.99(s, 3H), 3.12(s, 3H), 3.20(s, 3H), 3.58(s,



3H), 3.75(s, 3H), 4.93(s, 3H), 5.18(s, 2H), 6.67(s, 1H), 7.12(d,



J=8.7Hz, 1H), 7.34–7.49(m, 9H), 7.60–7.65(m, 2H)

















TABLE 39







I-165
m.p.148–151° C.



1HNMR(CDCl3)δ 3.03(s, 3H), 3.57(s, 3H), 3.74(s, 3H)4.89(s,



1H), 4.90(s, 2H), 5.15(s. 2H), 5.64(s, 1H), 6.67(s, 1H), 6.88–6.93



(m, 3H), 6.99(d, J=8.4Hz, 1H), 7.06(d, J=1.8Hz, 1H), 7.20–7.49



(m, 7H)



IR(KBr)3600–3200(br), 1609, 1590, 1519, 1477, 1459, 1381,



1253, 1216, 1156, 1111, 1077, 1066, 1012 cm−1


I-166
m.p.199° C.



1HNMR(CDCl3)δ 3.10(s, 3H), 3.21(s, 3H), 3.44(s, 3H), 3.76(s,



3H),5.17(s, 2H), 6.03(s, 1H), 6.44(s, 1H), 7.14(d, J=8.4Hz, 1H),



7.36–7.49 (m, 8H), 7.52(d, J=2.1Hz, 1H), 7.67–7.72(m, 2H)



IR(KBr)3600–3200(br), 1520, 1486, 1362, 1183, 1152, 1110, 971



cm−1


I-167
m.p.113–115° C.



1HNMR(CDCl3)δ 0.76(t, J=7.2Hz, 3H), 1.46–1.55(m, 2H), 3.11



(s, 3H), 3.20(s, 1H), 3.63(s, 1H), 3.71(t, J=6.6Hz, 2H), 5.18(s,



2H), 6.64 (s, 1H), 7.11(d, J=8.7Hz, 1H), 7.33–7.50(m, 9H), 7.60–



7.65(m, 2H)



IR(KBr)1517, 1475, 1365, 1345, 1293, 1233, 1177, 1149, 1109,



1079, 1017, 956 cm−1


I-168
m.p.56–58° C.



1HNMR(CDCl3)δ 0.76(t, J=7.5Hz, 3H), 1.44–1.56(m, 2H), 3.61



(s, 3H), 3.71(t, J=6.6Hz, 2H), 3.74(s, 3H), 4.86(s, 1H), 5.15(s,



2H), 5.63 (s, 1H), 6.65(s, 1H), 6.88–6.93(m, 3H), 6.98(d,J=8.4Hz,



1H), 7.04(d, J=1.8Hz, 1H), 7.37–7.50(m, 7H)



IR(KBr)3600–3200(br), 1611, 1590, 1519, 1476, 1404, 1379,



1252, 1230, 1110, 1078, 1015 cm−1


I-169
m.p.101–103° C.



1HNMR(CDCl3)δ 0.77(t, J=7.5Hz, 3H), 1.44–1.55(m, 2H), 1.76



(s, 3H), 1.81(s, 3H), 3.20(s, 3H), 3.21(s, 3H), 3.63(s, 3H), 3.71(t,



J=6.6 Hz,2H), 3.75(s, 3H), 4.63(d,J=6.6Hz, 2H), 5.48–5.53(m,



1H), 6.64(s, 1H), 7.04(d, J=8.4Hz, 1H), 7.32–7.38(m, 3H), 7.42(d,



J=2.1Hz, 1H), 7.60–7.65(m, 2H)



IR(KBr)1514, 1473, 1370, 1359, 1290, 1233, 1174, 1149, 1107,



970 cm−1

















TABLE 40







I-170
m.p.64–66° C.



1HNMR(CDCl3)δ 0.77(t, J=7.5Hz, 3H), 1.44–1.55(m, 2H), 1.76



(s, 3H), 1.81(s, 3H), 3.20(s, 3H), 3.21(s, 3H), 3.63(s, 3H), 3.71(t,



J=6.6 Hz, 2H), 3.75(s, 3H), 4.63(d, J=6.6Hz, 2H), 5.48–5.53(m,



1H), 6.64 (s, 1H), 7.04(d, J=8.4Hz, 1H), 7.32–7.38(m, 3H), 7.42



(d, J=2.1Hz, 1H),7.60–7.65(m, 2H)



IR(KBr)3600–2800(br), 1612, 1590, 1520, 1475, 1462, 1405,



1381, 1285, 1244, 1226, 1110, 1079, 988 cm−1


I-171
m.p.148–150° C.



1HNMR(CDCl3)δ 1.74(d, J=0.9Hz, 3H), 1.80(s, 3H), 2.88(s, 3H),



3.22(s, 3H), 3.23(s, 6H), 3.55(s, 3H), 3.80(s, 3H), 4.72(d, J=



7.5Hz, 2H), 5.55(m, 1H), 6.85(s, 1H), 7.39&7.67(ABq, J=8.7Hz,



4H), 7.40(s, 2H)



IR(KBr)1514, 1479, 1411, 1366, 1179, 1152, 1079, 1022, 968,



875, 799, 525 cm−1


I-172
1HNMR(CDCl3)δ 0.94(t, J=7.2Hz, 3H), 1.45(tq, J=7.2, 7.2 Hz,



2H), 2.13(m, 2H), 3.46(s, 3H), 3.74(s, 3H), 4.68(d, J=5.4Hz, 2H),



5.72 (m, 2H), 6.45(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.96(brs, 2H),



7.07(brs, 1H), 7.53(d, J=8.7Hz, 2H)


I-173
1HNMR(CDCl3)δ 1.76(brd, J=6.3Hz, 3H), 3.46(s, 3H), 3.74(s,



3H), 4.70(d, J=5.4Hz, 2H), 5.77(m, 2H), 6.45(s, 1H), 6.91(d, J=



8.7Hz, 2H), 6.96(brs, 2H), 7.07(brs, 1H), 7.53(d, J=8.7Hz, 2H)



IR(Nujol)3350, 1613, 1587, 1523, 1491, 1287, 1261, 1238, 1114,



1071, 1011, 936, 820, 783 cm−1


I-174
1HNMR(CDCl3)δ 3.45(s, 3H), 3.76(s, 3H), 4.56(s, 2H), 5.55(s,



1H), 6.45(s, 1H), 6.93(d, J=8.7Hz, 2H), 7.01(d, J=8.4Hz, 1H),



7.08 (dd, J=8.4, 2.1Hz, 1H), 7.27(d, J=2.1Hz, 1H), 7.54(d, J=



8.7Hz, 2H)


I-175
1HNMR(CDCl3)δ 3.45(s, 3H), 3.74(s, 3H), 4.82(dd, J=6.6, 1.5Hz,



2H), 5.28(d, J=10.5Hz, 1H), 5.35(d, J=16.5Hz, 1H), 5.75(dt, J=



10.8, 6.6Hz, 1H), 6.26(dd, J=10.5, 10.5Hz, 1H), 6.45(s, 1H), 6.66



(ddd, J=16.5, 10.5, 10.5Hz, 1H), 6.92(d, J=8.7Hz, 2H), 6.96(m,



2H), 7.07(br s, 1H), 7.53(d, J=8.7 Hz, 2H)



IR(Nujol)3399, 1611, 1591, 1523, 1489, 1248, 1226, 1113, 1071,



1009, 825 cm−1

















TABLE 41







I-176
1HNMR(CDCl3)δ 1.59(m, 6H), 2.17(m, 2H), 2.24, (m, 2H), 2.71



(s, 3H), 3.21(s, 3H), 3.24(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 4.65(d,



J=7.2Hz, 2H), 5.43(t, J=7.2Hz, 1H), 6.84(s, 1H), 7.10(d, J=8.4Hz,



1H), 7.34(dd, J=8.4, 2.1Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.39(d,



J=2.1Hz, 1H), 7.68(d, J=8.7Hz, 2H)


I-177
m.p.177–178° C.



1HNMR(CDCl3)δ 2.31(t, J=5.7Hz, 2H), 2.39(t, J=5.7Hz, 2H), 2.76



(s, 3H), 3.21(s, 3H), 3.24(s, 3H), 3.56(s, 3H), 3.70(t, J=5.7Hz,



2H), 3.73 (t, J=5.7Hz, 2H), 3.78(s, 3H), 4.67(d, J=6.6Hz, 2H),



5.57(t, J=6.6Hz, 1H), 6.84(s, 1H), 7.09(d, J=8.4Hz, 1H), 7.35(dd,



J=8.4, 2.1Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.39(d, J=2.1Hz, 1H),



7.67(d, J=8.7Hz, 2H)



IR(KBr)2940, 1519, 1481, 1362, 1178, 1152, 1079, 818 cm−1


I-178
1HNMR(CDCl3)δ 1.04(t, J=7.5Hz, 3H), 1.05(t, J=7.5Hz, 3H), 2.12



(q, J=7.5Hz, 2H), 2.16(q, J=7.5Hz, 2H), 2.71(s, 3H), 3.21(s, 3H),



3.24 (s, 3H), 3.56(s, 3H), 3.78(s, 3H), 4.67(d, J=6.6Hz, 2H), 5.45



(t, J=6.6Hz, 1H), 6.84(s, 1H), 7.11(d, J=8.4Hz, 1H), 7.35(dd, J=



8.4, 2.4Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.39(d, J=2.4Hz, 1H), 7.68



(d, J=8.7Hz, 2H)


I-179
1HNMR(CDCl3)δ 1.05(t, J=7.5Hz, 3H), 1.76(s, 3H), 2.10(q, J=



7.5Hz, 2H), 2.71(s, 3H), 3.21(s, 3H), 3.24(s, 3H), 3.56(s, 3H),



3.78(s, 3H), 4.66(d, J=6.9Hz, 2H), 5.48(t, J=6.9Hz, 1H), 6.84(s,



1H), 7.10(d, J=8.4Hz, 1H), 7.34(dd, J=8.4, 2.1Hz, 1H), 7.38(d, J=



8.7Hz, 2H), 7.39(d, J=2.1Hz, 1H), 7.68(d, J=8.7Hz, 2H)


I-180
1HNMR(CDCl3)δ 1.76(s, 3H), 1.80(s, 6H), 2.72(s, 3H), 3.21(s,



3H), 3.21(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 4.61(s, 2H), 6.84(s,



1H), 7.10(d, J=8.4Hz, 1H), 7.34(dd, J=8.4, 2.1Hz, 1H), 7.38(d,



J=8.7Hz, 2H), 7.39(d, J=2.1Hz, 1H), 7.68(d, J=8.7Hz, 2H)


I-181
m.p.157–158° C.



1HNMR(CDCl3)δ 1.55–1.65(m, 6H), 2.18(m, 2H), 2.23(m, 2H),



3.46(s, 3H), 3.74(s, 3H), 4.63d, J=7.2Hz, 2H), 5.47(t, J=7.2Hz,



1H), 6.45(s, 1H), 6.91(d, J=8.4Hz, 2H), 6.96(br.s, 2H), 7.06(br.s,



1H), 7.52(d, J=8.4Hz, 2H)



IR(KBr)3410, 2924, 2854, 1609, 1567, 1523, 1490, 1462, 1405,



1254, 1221, 1198, 1119, 1069, 824, 813 cm−1

















TABLE 42







I-182
m.p.219–221° C.



1HNMR(DMSO-d6)δ 2.22(t, J=5.4Hz, 2H), 2.32(t, J=5.4Hz,



2H), 3.30(s, 3H), 3.56(t, J=5.4Hz, 2H), 3.61(t, J=5.4Hz, 2H), 3.64



(s, 3H), 4.59(d, J=6.6Hz, 2H), 5.54(t, J=6.6Hz, 1H), 6.39(s, 1H),



6.64(dd, J=8.4, 2.1Hz, 1H), 6.73(d, J=2.1Hz, 1H), 6.84(d, J=



8.7Hz, 2H), 6.89(d, J=8.4Hz, 1H), 7.43(d, J=8.4Hz, 2H)



IR(KBr)3392, 2948, 1609, 1586, 1522, 1492, 1271, 1239, 1219,



1118, 1076, 1007, 818 cm−1


I-183
m.p.149–150° C.



1HNMR(CDCl3)δ 1.03(t, J=7.5Hz, 3H), 1.07(t, J=7.5Hz, 3H), 2.13



(q, J=7.5Hz, 2H), 2.15(q, J=7.5Hz, 2H), 3.46(s, 3H), 3.75(s, 3H),



4.64(d, J=6.6Hz, 2H), 5.48(t, J=6.6Hz, 1H), 6.45(s, 1H), 6.92(d,



J=8.7Hz, 2H), 6.97(dd, J=7.8, 1.5Hz, 1H), 6.97(d, J=7.8Hz, 1H),



7.06(d, J=1.5Hz, 1H), 7.52(d, J=8.7Hz, 2H)



IR(KBr)3398, 2963, 2934, 1671, 1610, 1523, 1493, 1465, 1407,



1259, 1224, 1118, 1071, 813 cm−1


I-184
m.p.217–218° C.



1HNMR(CDCl3)δ 3.86(s, 3H), 5.16(s, 2H), 5.72(s, 1H), 6.97–7.01



(m, 3H), 7.12(dd, J=2.4, 8.4Hz, 1H), 7.26(d, J=2.4Hz, 1H), 7.34–



7.47(m, 5H), 7.54–7.58(m, 2H), 7.60(s, 4H)



IR(KBr)3600–3200(br), 1605, 1590, 1493, 1298, 1282, 1253,



1206, 1183, 1022 cm−1


I-185
1HNMR(CDCl3)δ 1.21(t, J=6.9Hz, 3H), 1.77(s, 3H), 1.82(s, 3H),



2.38–2.46(m, 2H), 2.72–2.84(m, 2H), 3.18(s, 3H), 3.21(s, 3H),



3.35(s, 3H), 3.70(s, 3H), 4.06(q, J=6.9Hz, 2H), 4.63(d, J=6.6Hz,



2H), 5.52(t, J=6.6Hz, 1H), 6.75(s, 1H), 7.07(d, J=8.4Hz, 1H), 7.13



(d.d, J=8.4&2.1Hz, 1H), 7.21(d, J=2.1Hz, 1H), 7.37(d, J=9.0Hz,



2H), 7.69(d, J=9.0Hz, 2H)



IR(KBr)1727, 1517, 1469, 1364, 1291, 1234, 1179, 1152, 1118,



1080, 1003 cm−1


I-186
1HNMR(CDCl3)δ 1.76(s, 3H), 1.82(s, 3H), 2.42–2.53(m, 2H),



2.72–2.86(m, 2H), 3.35(s, 3H), 3.69(s, 3H), 4.61(d, J=6.6Hz, 2H),



5.53(t, J=6.6Hz, 1H), 5.71(s, 1H), 6.68(d.d, J=8.4&2.1Hz, 1H),



6.76(s, 1H), 6.81(d, J=2.1Hz, 1H), 6.91(d, J=8.4Hz, 2H), 6.92(d,



J=8.4Hz, 1H), 7.52(d, J=8.4Hz, 2H)



IR(KBr)3419, 1707, 1612, 1518, 1472, 1390, 1225, 1078 cm−1

















TABLE 43







I-187
1HNMR(CDCl3)δ 2.55(s, 3H), 3.54(s, 3H), 3.78(s, 3H), 5.18(s,



1H), 6.85(s, 1H), 6.91(d.d, J=8.4&2.1Hz, 1H), 7.03(d, J=8.4Hz,



1H), 7.04(d, J=2.1Hz, 1H), 7.33–7.48(m, 5H), 7.71(d, J=8.4Hz,



2H), 7.72(d, J=8.4Hz, 2H)



IR(KBr)3442, 1617, 1517, 1485, 1485, 1394, 1357, 1331, 1171,



1124, 1077, 1067, 1016 cm−1


I-188
1HNMR(CDCl3)δ 2.68(s, 3H), 3.13(s, 3H), 3.54(s, 3H), 3.79(s,



3H), 5.19(s, 2H), 6.86(s, 1H), 7.16(d, J=8.7Hz, 1H), 7.31–7.50(m,



7H), 7.72(d, J=8.7Hz, 2H), 7.76(d, J=8.7Hz, 2H)



IR(KBr)1614, 1513, 1482, 1366, 1324, 1177, 1120, 1079, 1065,



1016 cm−1


I-189
1HNMR(CDCl3)δ 2.68(s, 3H), 3.13(s, 3H), 3.54(s, 3H), 3.79(s,



3H), 5.19(s, 2H), 6.86(s, 1H), 7.16(d, J=8.7Hz, 1H), 7.31–7.50(m,



7H), 7.72(d, J=8.7Hz, 2H), 7.76(d, J=8.7Hz, 2H)



IR(KBr)1614, 1513, 1482, 1366, 1324, 1177, 1120, 1079, 1065,



1016 cm−1


I-190
1HNMR(CDCl3)δ 1.76(s, 3H), 1.82(s, 3H), 3.46(s, 3H), 3.76(s,



3H), 4.62(d, J=8.4Hz, 2H), 5.53(t, J=8.4Hz, 1H), 5.71(s, 1H), 5.85



(s, 1H), 6.46(s, 1H), 6.94(d.d, J=8.1&1.8Hz, 1H), 6.98(d, J=



8.1Hz, 1H), 7.05(d, J=1.8Hz, 1H), 7.71(d, J=8.1Hz, 2H), 7.77(d,



J=8.1Hz, 2H)



IR(KBr)3552, 3505, 3466, 1613, 1509, 1487, 1397, 1324, 1288,



1245, 1163, 1110, 1065 cm−1


I-191
1HNMR(CDCl3)δ 3.02(s, 6H), 3.48(s, 3H), 3.76(s, 3H), 5.15(s,



2H), 5.67(s, 1H), 5.95(s, 1H), 6.47(s, 1H), 6.81(d, J=8.7Hz, 2H),



6.96(d.d, J=8.4&2.1Hz, 1H), 7.04(d, J=8.4 Hz, 1H), 7.10(d,



J=2.1Hz, 1H), 7.31–7.49(m, 5H), 7.55(d, J=8.7Hz, 2H)



IR(KBr)3543, 3500, 1605, 1526, 1486, 1459, 1245, 1198, 1110,



1070, 999 cm−1


I-192
mp122–124° C.



1HNMR(CDCl3)δ 2.70(brs, 3H), 3.55–3.60(br, 2H), 3.60(s, 3H),



3.75(s, 3H), 3.81–3.83(m, 2H), 3.87(s, 3H), 5.15(s, 2H), 5.68(s,



1H), 6.69(s, 1H), 6.94(dd, J=2.1, 8.4Hz, 1H), 6.97–7.03(m, 3H),



7.07(d, J=1.8Hz, 1H), 7.38–7.48(m, 5H), 7.51–7.56(m, 2H)



IR(KBr)3600–2800(br), 1607, 1597, 1550, 1518, 1477, 1462,



1452, 1392, 1289, 1248, 1228, 1175, 1122, 1096, 1084, 1015 cm−1

















TABLE 44







I-193
m.p.160–163° C.



1HNMR(CDCl3)δ 3.60(s, 3H), 3.60–3.64(br, 2H), 3.76(s, 3H),



3.77–3.80(m, 2H, 5.15(s, 2H), 5.69(s, 1H), 5.88(s, 1H), 6.69(s,



1H), 6.90–6.94(m, 3H), 7.02(d, J=8.4Hz, 1H), 7.08(d, J=2.1Hz,



1H), 7.38–7.51(m, 7H)



IR(KBr)3600–3200(br), 1613, 1588, 1519, 1477, 1462, 1397,



1256, 1189, 1117, 1078, 1011 cm−1


I-194
1HNMR(CDCl3)δ 3.02(s, 6H), 3.11(s, 3H), 3.50(s, 3H), 3.72(s,



3H), 4,43(brs, 1H), 5.18(s, 2H), 6.82(d, J=8.7Hz, 2H), 6.92(s, 1H),



7.16(d, J=9.3Hz, 1H), 7.31–7.51(m, 7H), 7.55(d, J=8.7Hz, 2H)



IR(KBr)3432, 1611, 1526, 1476, 1356, 1291, 1232, 1186, 1117,



1079, 1012 cm−1


I-195
m.p.157–158° C.



1HNMR(CDCl3)δ 3.10(s, 3H), 3.21(s, 3H), 3.56(s, 3H), 3.69(s,



3H), 3.76(s, 3H), 4.47(s, 2H), 5.17(s, 2H), 6.68(s, 1H), 7.12(d, J=



8.2Hz, 1H), 7.34–7.50(m, 9H), 7.63(d, J=8.6Hz, 2H)



IR(KBr):1748, 1517, 1476, 1366, 1232, 1150, 1114, 968, 873,



812, 792, 750, 707 cm−1


I-196
m.p.189–191° C.(dec)



1HNMR(DMSO-d6)δ 3.45(s, 3H), 3.67(s, 3H), 4.25(s, 2H), 5.12(s,



2H), 6.66(dd, J=8.4, 2.0Hz, 1H), 6.69(s, 1H), 6.77(d, J=2.0Hz,



1H), 6.80(d, J=8.6Hz, 2H), 6.98(d, J=8.4Hz, 1H), 7.33–7.54(m,



7H), 9.01(s, 1H), 9.54(brs, 1H)



IR(KBr):3422, 3245, 1733, 1611, 1596, 1522, 1478, 1400, 1262,



1248, 1222, 1207, 1130, 1084, 1011, 836, 781, 744, 699 cm−1


I-197
m.p.151–152° C.



1HNMR(CDCl3)δ 1.76(s, 3H), 1.81(s, 3H), 3.20(s, 3H), 3.21(s,



3H), 3.56 (s, 3H), 3.70(s, 3H), 3.75(s, 3H), 4.47(s, 2H), 4.63(d, J=



6.9Hz, 2H), 5.51(t, J=6.9Hz, 1H), 6.68(s, 1H), 7.05(d, J=8.4Hz,



1H), 7.36(dd, J=8.4, 2.1Hz, 1H), 7.36(d, J=8.9Hz, 2H), 7.41(d,



J=2.1Hz, 1H), 7.63(d, J=8.9Hz, 2H)



IR(KBr):1751, 1517, 1475, 1366, 1234, 1150, 1113, 968, 872,



812, 707 cm−1

















TABLE 45







I-198
m.p.155–156° C.



1HNMR(DMSO-d6)δ 1.72(s, 3H), 1.76(s, 3H), 3.42(s, 3H), 3.67(s,



3H), 4.25(s, 2H), 4.54(d, J=6.8Hz, 2H), 5.49(t, J=6.8Hz, 1H),



6.65(dd, J=8.4, 1.9Hz, 1H), 6.69(s, 1H), 6.73(d, J=1.9Hz, 1H),



6.84(d, J=8.4Hz, 2H), 7.36(d, J=8.4Hz, 1H), 7.41(d, J=8.4Hz,



2H), 8.85(s, 1H), 9.55(s, 1H), 11.2–13.6(brs, 1H)



IR(KBr):3411, 3243, 1733, 1611, 1594, 1522, 1477, 1398, 1247,



1207, 1126, 1083, 1015, 835, 788 cm−1


I-199
1HNMR(CDCl3)δ 2.68(s, 3H), 3.13(s, 3H), 3.55(s, 3H), 3.80(s,



3H), 5.19(s, 2H), 6.88(s, 1H), 7.16(d, J=8.7Hz, 1H), 7.34(d, J=



2.1Hz, 1H), 7.36–7.50(m, 6H), 7.81(d, J=8.4Hz, 2H), 7.98(d, J=



8.4Hz, 2H)



IR(KBr)1698, 1602, 1481, 1351, 1232, 1182, 1079 cm−1


I-200
1HNMR(CDCl3)δ 2.42(s, 3H), 2.71(s, 3H), 3.03(s, 3H), 3.21(s,



3H), 3.56(s, 3H), 3.79(s, 3H), 5.17(s, 2H), 6.84(s, 1H), 7.19(d, J=



8.4Hz, 1H), 7.22–7.30(m, 3H), 7.37(dd, J=8.4, 2.1Hz, 1H), 7.38(d,



J=8.7 Hz, 2H), 7.41(d, J=2.1Hz, 1H), 7.41–7.45(m, 1H), 7.68(d,



J=8.7Hz, 2H)



IR(Nujol)1607, 1519, 1480, 1177, 1151, 1079, 970, 875, 798 cm−1


I-201
1HNMR(CDCl3)δ 2.38(s, 3H), 2.67(s, 3H), 3.14(s, 3H), 3.21(s,



3H), 3.56(s, 3H), 3.78(s, 3H), 5.15(s, 2H), 6.84(s, 1H), 7.14(d, J=



8.4Hz, 1H), 7.17(brd, J=7.5Hz, 1H), 7.23–7.30(m, 3H), 7.34(dd,



J=8.4, 1.8Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.41(d, J=1.8Hz, 1H),



7.68(d, J=8.7Hz, 2H)



IR(Nujol)1606, 1519, 1482, 1180, 1150, 1078, 1011, 979, 876,



790 cm−1


I-202
1HNMR(CDCl3)δ 2.30(s, 3H), 2.38(s, 6H), 2.74(s, 3H), 2.94(s,



3H), 3.21(s, 3H), 3.57(s, 3H), 3.79(s, 3H), 5.13(s, 2H), 6.85(s,



1H), 6.91(brs, 2H), 7.37(d, J=8.7 Hz, 2H), 7.40(brs, 2H), 7.41



(dd, J=8.4, 1.8Hz, 1H), 7.69(d, J=8.7Hz, 2H)



IR(CHCl3)1610, 1518, 1477, 1370, 1177, 1149, 1082, 970, 873



cm−1


I-203
1HNMR(CDCl3)δ 2.34(s, 6H), 2.66(s, 3H), 3.15(s, 3H), 3.21(s,



3H), 3.56(s, 3H), 3.78(s, 3H), 5.12(s, 2H), 6.84(s, 1H), 6.99(brs,



1H), 7.06(brs, 2H), 7.14(d, J=8.4Hz, 1H), 7.33(dd, J=8.4, 2.1Hz,



1H), 7.38(d, J=8.7Hz, 2H), 7.40(d, J=2.1Hz, 1H), 7.68(d, J=8.7Hz,



2H)



IR(Nujol)1607, 1519, 1480, 1178, 1152, 1097, 1014, 969, 876,



824, 797 cm−1

















TABLE 46







I-204
1HNMR(CDCl3)δ 2.72(s, 3H), 3.16(s, 3H), 3.21(s, 3H), 3.55(s,



3H), 3.78(s, 3H), 3.94(s, 3H), 5.25(s, 2H), 6.84(s, 1H), 7.11(d, J=



8.4Hz, 1H), 7.34(dd, J=8.4, 2.1Hz, 1H), 7.38(d, J=8.7Hz, 2H),



7.42(d, J=2.1Hz, 1H), 7.55(d, J=8.4Hz, 2H), 7.68(d, J=8.7Hz,



2H), 8.09(d, J=8.4Hz, 2H)



IR(Nujol)1719, 1610, 1519, 1480, 1177, 1151, 1119, 1080, 1016,



969, 875, 798 cm−1


I-205
m.p.153–157° C.



1HNMR(CDCl3)δ 2.70(s, 3H), 3.16(s, 3H), 3.21(s, 3H), 3.56(s,



3H), 3.78(s, 3H), 5.13(s, 2H), 6.41(dd, J=3.3, 2.0Hz, 1H), 6.49(d,



J=3.3Hz, 1H), 6.84(s, 1H), 7.20(d, J=8.7Hz, 1H), 7.37(dd, J=



8.7, 2.1Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.41(d, J=2.1Hz, 1H),



7.46(d, J=2.0Hz, 1H), 7.68(d, J=8.7Hz, 2H)



IR(Nujol)1605, 1518, 1482, 1375, 1361, 1180, 1150, 1079, 1013,



977, 876, 814, 800 cm−1


I-206
1HNMR(CDCl3)δ 2.41(s, 3H), 3.46(s, 3H), 3.75(s, 3H), 5.13(s,



2H), 6.45(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.99(dd, J=8.4, 2.1Hz,



1H), 7.07(d, J=8.4Hz, 1H), 7.09(d, J=2.1Hz, 1H), 7.22–7.34(m,



3H), 7.40(brd, J=7.8Hz, 1H), 7.53(d, J=8.7Hz, 2H)



IR(Nujol)3471, 3436, 3339, 1612, 1581, 1523, 1489, 1266, 1245,



1228, 1185, 1110, 1070, 1011, 998, 945, 823, 781 cm−1


I-207
1HNMR(CDCl3)δ 2.40(s, 3H), 3.45(s, 3H), 3.75(s, 3H), 5.11(s,



2H), 6.45(s, 1H), 6.91(d, J=8.7Hz, 2H), 6.95(dd, J=8.4, 1.8Hz,



1H), 7.01(d, J=8.4Hz, 1H), 7.09(d, J=1.8Hz, 1H), 7.19(brd, J=



7.5Hz, 1H), 7.22–7.34(m, 3H), 7.53(d, J=8.7Hz, 2H)



IR(Nujol)3410, 1611, 1589, 1523, 1489, 1246, 1225, 1114, 1071,



1011, 939, 824, 814, 778 cm−1


I-208
m.p.230–236° C.



1HNMR(DMSO-d6)δ 2.25(s, 3H), 2.35(s, 6H), 3.31(s, 3H), 3.65(s,



3H), 5.00(s, 2H), 6.39(s, 1H), 6.69(dd, J=8.4, 1.8Hz, 1H), 6.76(d,



J=1.8Hz, 1H), 6.84(d, J=8.7Hz, 1H), 6.90(brs, 2H), 7.06(d, J=



8.4Hz, 3H), 7.44(d, J=8.7Hz, 2H)



IR(Nujol)3475, 3361, 1609, 1579, 1521, 1260, 1244, 1110, 1071,



1012, 988, 822, 782 cm−1


I-209
1HNMR(CDCl3)δ 2.35(s, 6H), 3.45(s, 3H), 3.75(s, 3H), 5.07(s,



2H), 6.45(s, 1H), 6.91(d, J=8.7Hz, 2H), 6.95(dd, J=8.4, 1.8Hz,



1H), 7.01(brs, 1H), 7.02(d, J=8.4Hz, 1H), 7.06(brs, 2H), 7.08(d,



J=1.8Hz, 1H), 7.53(d, J=8.7Hz, 2H)



IR(Nujol)3410, 1610, 1588, 1523, 1489, 1248, 1225, 1114, 1071,



1011, 940, 825, 808, cm−1






















I-210
1HNMR(CD3OD)δ 3.37(s, 3H), 3.67(s, 3H), 5.25(s, 2H), 6.43(s,



1H), 6.77(dd, J=8.4, 2.1Hz, 1H), 6.84(d, J=8.7Hz, 2H), 6.89(d,



J=2.1Hz, 1H), 6.94(d, J=8.4Hz, 1H), 7.45(d, J=8.7Hz, 2H), 7.60



(d, J=8.4Hz, 2H), 8.04(d, J=8.4Hz, 2H)



IR(Nujol)3384, 1694, 1612, 1591, 1523, 1488, 1249, 1113, 1071,



1013, 940, 826, 812, 765 cm−1


I-211
1HNMR(CDCl3)δ 3.45(s, 3H), 3.74(s, 3H), 5.09(s, 3H), 6.41(dd,



J=3.3, 1.8Hz, 1H), 6.45(s, 1H), 6.47(d, J=3.3Hz, 1H), 6.92(d, J=



8.7Hz, 2H), 6.97(dd, J=8.4, 2.1Hz, 1H), 7.07(d, J=2.1Hz, 1H),



7.08(d, J=8.4Hz, 1H), 7.48(dd, J=1.8, 1.0Hz, 1H), 7.54(d, J=



8.7Hz, 2H)



IR(Nujol)3410, 1612, 1589, 1523, 1489, 1248, 1226, 1113, 1071,



1011, 939, 815, 747 cm−1


I-212
m.p.156–158° C.



1HNMR(CDCl3)δ 1.06(t, J=7.4Hz, 3H), 1.75(s, 3H), 2.10(q, J=



7.4Hz, 2H), 3.46(s, 3H), 3.75(s, 3H), 4.64(d, J=7.0Hz, 2H), 5.52



(t, J=7.0Hz, 1H), 6.45(s, 1H), 6.92(d, J=8.6Hz, 2H), 6.96(br.s,



2H), 7.06(br.s, 1H), 7.53(d, J=8.6Hz, 2H)



IR(KBr)3392, 2960, 2934, 1610, 1583, 1568, 1523, 1492, 1465,



1406, 1259, 1241, 1224, 1198, 1118, 1071, 824, 812 cm−1


I-213
m.p.175–177° C.



1HNMR(CDCl3)δ 1.77(s, 3H), 1.80(s, 6H), 3.46(s, 3H), 3.75(s,



3H), 4.59(s, 2H), 6.45(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.96(br.s,



2H), 7.06(br.s, 1H), 7.53(d, J=8.7Hz, 2H)



IR(KBr)3449, 2929, 1612, 1581, 1523, 1489, 1403, 1262, 1243,



1228, 1113, 1070, 823, 807 cm−1


I-214
1HNMR(CDCl3)δ 1.66(tt, J=6.6, 6.6Hz, 2H), 1.74(tt, J=6.6, 6.6



Hz, 2H), 2.32(t, J=6.6Hz, 2H), 2.34(t, J=6.6Hz, 2H), 2.71(s, 3H),



3.21(s, 3H), 3.24(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 4.62(d, J=6.9



Hz, 2H), 5.60(m, 1H), 6.84(s, 1H), 7.09(d, J=8.7Hz, 1H), 7.34(dd,



J=8.7, 2.1Hz, 1H), 7.37(d, J=8.7Hz, 2H), 7.38(d. J=2.1Hz, 1H),



7.67(d, J=8.7Hz, 2H)



IR(KBr)2941, 1610, 1518, 1418, 1365, 1177, 1151, 1079, 847, 818



cm−1


I-215
1HNMR(CDCl3)δ 1.57–1.72(m, 4H), 2.05–2.13(m, 4H), 2.70(s,



3H), 3.21(s, 3H), 3.23(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 4.48(s,



2H), 5.86(s, 1H), 6.84(s, 1H), 7.09(d, J=8.4Hz, 1H), 7.34(dd, J=



8.4, 2.1Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.38(d, J=2.1Hz, 1H), 7.67



(d, J=8.7Hz, 2H)



IR(KBr)2936, 1610, 1518, 1481, 1365, 1177, 1151, 1079, 818



cm−1

















TABLE 48







I-216
1HNMR(CDCl3)δ 1.74(d, J=6.6Hz, 3H), 2.54(d, J=2.1Hz, 1H),



2.70(s, 3H), 3.21(s, 3H), 3.24(s, 3H), 3.56(s, 3H), 3.78(s, 3H),



5.00(dd, J=6.6, 2.1Hz, 1H), 6.84(s, 1H), 7.28(d, J=8.7Hz, 1H),



7.36(dd, J=8.7, 2.1Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.41(d, J=2.1



Hz, 1H), 7.68(d, J=8.7Hz, 2H)



IR(KBr)3282, 3023, 2940, 1609, 1519, 1481, 1365, 1177, 1151,



1079, 970, 815 cm−1


I-217
m.p.80–85° C.



1HNMR(CDCl3)δ 1.62–1.77(m, 4H), 2.25–2.39(m, 4H), 3.46(s,



3H), 3.75(s, 3H), 4.60(d, J=7.0Hz, 2H), 5.63(m, 1H), 6.45(s, 1H),



6.92(d, J=8.6Hz, 1H), 6.95(br.s, 2H), 7.06(br.s, 1H), 7.68(d, J=



8.6Hz, 2H)



IR(KBr)3282, 3023, 2940, 1609, 1519, 1481, 1365, 1177, 1151,



1079, 970, 815 cm−1


I-218
foam



1HNMR(CDCl3)δ 3.45(s, 3H),3.77(s, 3H), 5.16(s, 2H), 5.69(brs,



1H), 5.86(s, 1H), 6.47(s, 1H), 6.95(dd, J=2.1, 8.4Hz, 1H), 7.04(d,



J=8.4Hz, 1H), 7.08(d, J=2.1Hz, 1H), 7.34–7.65(m, 7H), 7.83–7.92



(m, 2H)



IR(CHCl3)3530, 3022, 1614, 1588, 1500, 1485, 1463, 1405, 1326,



1290, 1249, 1168, 1130, 1117, 1073, 1011 cm−1


I-219
foam



1HNMR(CDCl3)δ 1.69(s, 3H), 1.74(s, 3H), 2.51–2.59(m, 2H),



2.74(s, 3H), 3.22(s, 3H), 3.55(s, 3H), 3.79(s, 3H), 4.07(t, J=6.6Hz,



2H), 5.21(m, 1H), 6.85(s, 1H), 7.08(d, J=8.7Hz, 1H), 7.35(dd, J=



2.1, 8.7Hz, 1H), 7.39(d, J=2.1Hz, 1H), 7.55–7.69(m, 2H), 7.81–



7.87(m, 2H)



IR(CHCl3)3024, 1609, 1519, 1481, 1467, 1396, 1369, 1321, 1272,



1179, 1122, 1082, 1015 cm−1


I-220
m.p.124–126° C.



1HNMR(CDCl3)δ 1.69(s, 3H), 1.75(s, 3H), 2.50–2.57(m, 2H),



3.46(s, 3H), 3.76(s, 3H), 4.07(t, J=6.9Hz, 2H), 5.22(m, 1H), 5.69



(brs, 1H), 5.84(s, 1H), 6.46(s, 1H), 6.93–7.05(m, 3H), 7.55–



7.65(m, 2H), 7.82–7.91(m, 2H),



IR(KBr)3406, 2935, 1587, 1519, 1501, 1488, 1459, 1359, 1323,



1304, 1291, 1274, 1223, 1170, 1126, 1113, 1075, 1018 cm−1

















TABLE 49







I-221
m.p.187–189° C.



1HNMR(CDCl3)δ 2.33(s, 3H), 2.69(s, 3H), 3.21(s, 3H), 3.24(s,



3H), 3.55(s, 3H), 3.77(s, 3H), 4.17(s, 2H), 6.84(s, 1H), 7.12&7.25



(ABq, J=8.7Hz, 4H), 7.31(dd, J=8.1Hz, J=1.5Hz, 1H), 7.38&



7.67(ABq, J=8.7Hz, 4H), 7.42(d, J=8.1Hz, 1H), 7.46(d, J=1.5



Hz, 1H)



IR(KBr)1512, 1474, 1417, 1391, 1356, 1343, 1177, 1149, 1082,



1054, 1013, 976, 961, 939, 867, 854, 844, 820, 812, 799, 523 cm−1


I-222
m.p.107–112° C.



1HNMR(CDCl3)δ 2.73(s, 3H), 3.22(s, 3H), 3.28(s, 3H), 3.55(s,



3H), 3.77(s, 3H), 4.34(s, 2H), 6.84(s, 1H), 7.19(m, 1H), 7.30(dd,



J=8.1Hz, J=1.8Hz, 1H), 7.34–7.41(m, 3H), 7.46(d, J=1.8Hz, 1H),



7.49(d, J=8.1Hz, 1H), 7.62–7.69(m, 3H), 8.55(m, 1H)



IR(KBr)1474, 1389, 1364, 1179, 1151, 1081, 937, 873, 813, 797,



523 cm−1


I-223
m.p.212–214° C.



1HNMR(CDCl3+CD3OD)δ 3.45(s, 3H), 3.74(s, 3H), 4.13(s,



2H), 6.45(s, 1H), 6.90–6.96(m, 3H), 7.12(d, J=1.8Hz, 1H), 7.18–



7.26(m, 2H), 7.48–7.54(m, 3H), 7.68(m, 1H), 8.63(m, 1H)



IR(KBr)3504, 3272, 1612, 1596, 1574, 1521, 1492, 1463, 1436,



1405, 1362, 1310, 1265, 1222, 1172, 1116, 1083, 1052, 1017, 828



cm−1


I-224
m.p.199–200° C.



1HNMR(CDCl3)δ 1.46(d, J=0.9Hz, 3H), 1.77(s, 3H), 3.44(s, 3H),



3.74(s, 3H), 3.90(m, 2H), 5.25(m, 1H), 6.04(brs, 1H), 6.45(s, 1H),



6.93&7.53(ABq, J=8.7Hz, 4H), 7.00(m, 2H), 7.05(m, 1H)



IR(KBr)3404, 2999, 2932, 1612, 1595, 1522, 1483, 1454, 1432,



1401, 1376, 1357, 1271, 1223, 1119, 1080, 1055, 1015, 974, 938,



829, 817 cm−1


I-225
m.p.181–183° C.



1HNMR(CDCl3)δ 1.37(s, 9H), 3.45(s, 3H), 3.75(s, 3H), 4.93(brs,



1H), 6.00(s, 1H), 6.46(s, 1H), 6.93&7.54(ABq, J=8.7Hz, 4H), 6.99



(s, 1H), 7.01(dd, J=8.4Hz, J=1.5Hz, 1H), 7.16(d, J=1.5Hz, 1H),



7.49(d, J=8.4Hz, 1H)



IR(KBr)3495, 3412, 2959, 2931, 1610, 1568, 1552, 1521, 1499,



1477, 1459, 1400, 1364, 1319, 1270, 1227, 1192, 1161, 1116,



1102, 1090, 1052, 1019, 942, 833, 817, 588 cm−1

















TABLE 50







I-226
m.p.154–156° C.



1HNMR(CDCl3)δ 2.33(s, 3H), 3.45(s, 3H), 3.75(s, 3H), 3.90(s,



2H), 4.68(s, 1H), 5.97(s, 1H), 6.45(s, 1H), 6.60(s, 1H), 6.90–6.98



(m, 3H), 7.10(s, 5H), 7.41(d, J=8.1Hz, 1H), 7.53(m, 2H)



IR(KBr)3462, 3368, 1611, 1550, 1521, 1499, 1472, 1455, 1437,



1401, 1362, 1321, 1293, 1267, 1229, 1187, 1174, 1164, 1118,



1077, 1050, 1011, 821 cm−1


I-227
m.p.172–174° C.



1HNMR(CDCl3)δ 1.38(d, J=1.2Hz, 3H), 1.76(s, 3H), 3.44(s,



3H), 3.75(s, 3H), 3.87(d, J=7.8Hz, 2H), 5.08(brs, 1H), 5.26(m,



1H), 6.08(s, 1H), 6.45(s, 1H), 6.94&7.53(ABq, J=8.7Hz, 4H),



7.11–7.14(m, 2H), 7.62(d, J=8.7Hz, 1H), 8.87(s, 1H)



IR(KBr)3412, 1613, 1520, 1478, 1458, 1443, 1404, 1360, 1346,



1290, 1270, 1224, 1200, 1171, 1119, 1078, 1054, 945 cm−1


I-228
m.p.173–175° C.



1HNMR(CDCl3)δ 1.69(s, 3H), 1.74(s, 3H), 2.10(s, 3H), 2.50–



2.61(m, 2H), 3.20(s, 3H), 3.21(s, 3H), 3.37(s, 3H), 3.71(s, 3H),



4.08(t, J=6.8Hz, 2H), 5.21–5.25(m, 1H), 6.73(s, 1H), 7.03–7.18



(m, 2H), 7.23–7.25(m, 2H), 7.37(d, J=8.6Hz, 2H), 7.69(d, J=



8.8Hz, 2H)



IR(KBr)3600–3200(br), 3100–2800(br), 1610, 1527, 1523,



1477, 1432, 1365, 1240, 1172, 1160, 955, 923 cm−1


I-229
m.p.148–150° C.



1HNMR(CDCl3)δ 1.70(s, 3H), 1.77(s, 3H), 2.09(s, 3H), 2.48–



2.62(m, 2H), 3.38(s, 3H), 3.73(s, 3H), 4.09(t, J=7.0Hz, 2H), 4.84



(br, 1H), 5.19–5.22(m, 1H), 5.70(s, 1H), 6.71–6.96(m, 5H), 7.55



(d, J=8.2Hz, 2H)



IR(KBr)3700–3200(br), 3100–2800(br), 1612, 1584, 1560, 1448,



1428, 1390, 1339, 1315, 1284, 1246, 1173, 1160, 1123, 1018, 999



cm−1


I-230
m.p.194–195° C.



1HNMR(CDCl3)δ 2.10(s, 3H), 2.39(s, 3H), 3.10(s, 3H), 3.21(s,



3H), 3.36(s, 3H). 3.71(s, 3H), 5.13(s, 2H), 6.73(s, 1H), 7.14–7.18



(m, 8H), 7.69(d, J=9.0Hz, 2H)



IR(KBr)3600–3200(br), 3100–2800(br), 1516, 1475, 1360, 1332,



1292, 1266, 1228, 1199, 1174, 1151, 1119, 1098, 1084, 1005, 968



cm−1

















TABLE 51







I-231
m.p.178–180° C.



1HNMR(CDCl3)δ 2.09(s, 3H), 2.40(s, 3H), 3.37(s, 3H), 3.72(s,



3H), 4.97(brs, 1H), 5.10(s, 2H), 5.67(br, 1H), 6.70–6.75(m, 2H),



6.86–7.03(m, 3H), 7.22–7.26(m, 2H), 7.32–7.34(m, 2H), 7.54(d,



J=8.2Hz, 2H)



IR(KBr)3600–3200(br), 3100–2800(br), 1611, 1519, 1479, 1463,



1388, 1339, 1314, 1286, 1258, 1246, 1225, 1128, 1098, 1077,



1007 cm−1


I-232
m.p.177–179° C.



1HNMR(CDCl3)δ 2.54(s, 3H), 2.69(s, 3H), 3.13(s, 3H), 3.54(s,



3H), 3.77(s, 3H), 5.19(s, 2H), 6.85(s, 1H), 7.15(d, J=8.4Hz, 2H),



7.30–7.49(m, 9H), 7.53–7.59(m, 2H)



IR(CHCl3)1516, 1476, 1368, 1266, 1176, 1118, 1077, 1080, 1013,



970, 876, 820, cm−1


I-233
amorphouspowder



1HNMR(CDCl3)δ 2.54(s, 3H), 3.46(s, 3H), 3.75(s, 3H), 5.15(s,



2H), 5.67(brs, 1H), 5.90(s, 1H), 6.46(s, 1H), 6.95(d.d, J=1.8&8.1



Hz, 1H), 7.02(d, J=8.1Hz, 1H), 7.09(d, J=1.8Hz, 1H), 7.31–7.49



(m, 7H), 7.55–7.62(m, 2H)



IR(CHCl3)3526, 1517, 1483, 1414, 1389, 1289, 1246, 1192, 1114,



1070, 1010, 937, 818 cm−1


I-234
1HNMR(CDCl3)δ 1.76(s, 3H), 1.81(s, 3H), 2.73(s, 3H), 3.24(s,



3H), 3.53(s, 3H), 3.79(s, 3H), 3.96(s, 3H), 4.64(d, J=6.9Hz, 2H),



5.49(t, J=6.9Hz, 1H), 6.87(s, 1H), 7.09(d, J=8.4Hz, 1H), 7.35(d.d,



J=8.4&2.1Hz, 1H), 7.39(d, J=2.1Hz, 1H), 7.71(d, J=8.4Hz, 2H),



8.13(d, J=8.4Hz, 2H)


I-235
1HNMR(CDCl3)δ 2.69(s, 3H), 3.14(s, 3H), 3.55(s, 3H), 3.80(s,



3H), 5.20(s, 2H), 6.89(s, 1H), 7.16(d, J=9.0Hz, 1H), 7.34(d, J=



2.1Hz, 1H), 7.36–7.51(m, 6H), 7.75(d, J=8.4Hz, 2H), 8.23(d, J=



8.4Hz, 2H)



IR(KBr)3427, 1724, 1685, 1606, 1509, 1481, 1369, 1272, 1235,



1179, 1120, 1084, 1017 cm−1


I-236
1HNMR(CDCl3)δ 3.46(s, 3H), 3.77(s, 3H), 5.16(s, 3H), 6.50(s,



3H), 6.96(dd, J=8.4&2.1Hz, 1H), 7.03(d, J=8.4Hz, 1H), 7.09(d, J=



2.1Hz, 1H), 7.34–7.50(m, 5H), 7.75(d, J=8.1Hz, 2H), 8.17(d, J=



8.1Hz, 2H)

















TABLE 52







I-237
1HNMR(CDCl3)δ 3.44(s, 3H), 3.76(s, 3H), 3.96(s,



3H), 5.16(s, 2H), 5.69(s, 1H), 5.89(s, 1H), 6.49(s, 1H), 6.96



(d.d, J=8.4&2.1Hz, 1H), 7.03(d, J=8.4Hz, 1H), 7.09(d, J=2.1



Hz, 1H), 7.32–7.50(m, 5H), 7.73(d, J=8.4Hz, 2H), 8.13(d,



J=8.4Hz, 2H)



IR(KBr)3497, 3443, 1708, 1608, 1585, 1487, 1460, 1443



1395, 1281, 1113, 1068, 1008 cm−1


I-238
1HNMR(CDCl3)δ 2.69(s, 3H), 3.13(s, 3H), 3.53(s, 3H), 3.79(s,



3H), 3.96(s, 3H), 5.19(s, 2H), 6.87(s, 1H), 7.15(d, J=9.0Hz,



1H), 7.31–7.50(m, 7H), 7.71(d, J=8.4Hz, 2H), 8.13(d,



J=8.4Hz, 2H)



IR(KBr)1719, 1608, 1481, 1366, 1278, 1118, 1080, 1017 cm−1


I-239
1HNMR(CDCl3)δ 2.38(s, 3H), 2.68(s, 3H), 3.12(s, 3H), 3.53(s,



3H), 3.79(s, 3H), 3.96(s, 3H), 5.14(s, 2H), 6.87(s, 1H), 7.15(d,



J=8.7Hz, 1H), 7.21(d, J=8.4Hz, 2H), 7.34(d, J=8.4Hz, 2H),



7.36(d, J=8.7Hz, 1H), 7.40(d, J=2.1Hz, 1H), 7.71(d, J=



8.7Hz, 2H), 8.13(d, J=8.4Hz, 2H)



IR(KBr)1718, 1607, 1519, 1481, 1355, 1280, 1232, 1182,



1121, 1079, 1018 cm−1


I-240
1HNMR(CDCl3)δ 2.70(s, 3H), 3.03(s, 3H), 3.12(s, 3H), 3.55(s,



3H), 3.77(s, 3H), 5.18(s, 2H), 6.78–6.89(broad, 1H), 6.86(s,



1H), 7.14(d, J=8.4Hz, 1H), 7.31–7.49(m, 8H), 7.55(d,



J=8.4Hz, 2H)



IR(KBr)1604, 1526, 1483, 1395, 1374, 1360, 1292, 1231,



1177, 1119, 1078, 1014 cm−1


I-241
1HNMR(CDCl3)δ 2.37(s, 3H), 2.69(s, 3H), 3.05(s, 3H), 3.12(s,



3H), 3.55(s, 3H), 3.77(s, 3H), 5.14(s, 2H), 6.85(s, 1H), 6.81–



6.91(broad, 2H), 7.14(d, J=8.4Hz, 1H), 7.21(d, J=8.1Hz, 1H),



7.34(d, J=8.1Hz, 2H), 7.40(d, J=2.1Hz, 1H), 7.56(d,



J=8.4Hz, 2H)



IR(KBr)1605, 1529, 1484, 1396, 1356, 1275, 1233, 1178,



1121, 1078, 1016 cm−1


I-242
1HNMR(CDCl3)δ 1.76(s, 3H), 1.81(s, 3H), 2.73(s, 3H), 3.03(s,



6H), 3.22(s, 3H), 3.55(s, 3H), 3.77(s, 3H), 4.63(d, J=6.6Hz,



2H), 5.49(t, J=6.6Hz, 1H), 6.75–6.91(broad, 2H), 6.86(s,



1H), 7.08(d, J=8.7Hz, 1H), 7.34(d.d, J=8.7&2.1Hz, 1H),



7.39(d, J=2.1Hz, 1H), 7.55(d, J=8.7Hz, 1H)



IR(KBr)1609, 1529, 1482, 1363, 1235, 1178, 1117, 1078,



1013 cm−1


I-243
IR(KBr)3409, 1608, 1509, 1464, 1367, 1230, 1175,



1149, 1079, 1018 cm−1

















TABLE 53







I-244
1HNMR(CDCl3)δ 1.72(s, 3H), 1.76(s, 3H), 2.55(m,



2H), 3.22(s, 3H), 3.45(s, 3H), 3.72(s, 3H), 4.07(d, J=6.6Hz,



2H), 4.46(d, J=10.5Hz, 1H), 4.51(d, J=10.5Hz, 1H), 4.66(d,



J=10.5Hz, 1H), 4.75(d, J=10.5Hz, 1H), 5.24(brs, 1H), 6.84



(s, 1H), 6.95(d, J=8.7Hz, 1H), 7.02(s, 1H), 7.21(d, J=8.7Hz,



1H), 7.39(d, J=9.0Hz, 2H), 7.71(d, J=9.0Hz, 2H)



IR(KBr)3307, 1609, 1509, 1465, 1364, 1235, 1180,



1152, 1082, 1021 cm−1


I-245
m.p. 182–184° C.



1HNMR(CDCl3)δ 2.42(s, 3H), 2.70(s, 3H), 3.13(s, 3H), 3.53(s,



3H), 3.77(s, 3H), 5.19(s, 2H), 6.86(s, 1H), 7.13–7.53(m, 12H)



IR(KBr)3434, 3030, 2937, 1605, 1522, 1483, 1366, 1274,



1235, 1176, 1119, 1086, 1011 cm−1


I-246
1HNMR(CDCl3)δ 2.58(s, 3H), 3.21(s, 3H), 3.55(s, 3H),



3.77(s, 3H), 3.91(s, 3H), 5.26(m, 2H), 6.84(s, 1H), 7.12(d, J=



9.0Hz, 1H), 7.27–7.54(m, 8H), 7.60(d, J=8.7Hz, 2H), 7.90(d,



J=2.1Hz, 1H)



IR(KBr)1728, 1699, 1605, 1513, 1480, 1362, 1239, 1175,



1150, 1083, 1017 cm−1


I-247
IR(KBr)1729, 1607, 1512, 1479, 1366, 1234, 1177,



1151, 1079, 1015 cm−1


I-248
1H NMR (CDCl3)δ 1.75(s, 3H), 1.79(s, 3H), 2.57(s, 3H), 3.21



(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 3.89(s, 3H), 4.63(d, J=6.6Hz,



2H), 5.49–5.58(m, 1H), 6.85(s, 1H), 6.93–7.00(m, 3H), 7.38(d,



J=8.7Hz, 2H), 7.70(d, J=8.7Hz, 2H)



IR(KBr)1603, 1518, 1482, 1365, 1239, 1176, 1150, 1078 cm−1


I-249
foam



1HNMR(CDCl3)δ 2.30(br, 1H), 2.76–2.82(m, 2H), 3.64–3.68



(m, 2H), 3.87(s, 1H), 5.14(s, 2H), 5.70(s, 1H), 6.70(dd,



J=2.1, 8.4Hz, 1H), 6.78(s, 1H), 6.84(d, J=1.8Hz, 1H), 6.97–



7.01(m, 3H), 7.37–7.49(m, 5H), 7.56–7.61(m, 2H)



IR(KBr)3600–2800(br), 1608, 1583, 1517, 1464, 1387,



1287, 1247, 1225, 1178, 1082, 1015 cm−1


I-250
m.p. 104–105° C.



1HNMR(CDCl3)δ 0.76(t, J=7.5Hz, 3H), 1.44–1.54(m, 2H),



3.61(s, 3H), 3.71(t, J=6.6Hz, 2H), 3.74(s, 3H), 3.87(s, 3H),



5.16(s, 2H), 5.63(s, 1H), 6.66(s, 1H), 6.90(dd, J=2.1, 8.4Hz,



1H), 6.96–7.01(m, 4H), 7.04(d, J=1.8Hz, 1H), 7.37–7.48



(m, 5H), 7.51–7.56(m, 2H)



IR(KBr)3600–2800(br), 1608, 1593, 1518, 1474, 1462, 1379,



1294, 1251, 1226, 1183, 1109, 1078, 1040 1008 cm−1

















TABLE 54







I-251
m.p.103–105° C.



1HNMR(CDCl3)δ 0.78(t, J=7.2Hz, 3H), 1.15–1.27(m, 2H), 1.43–



1.51(m, 2H), 3.61(s, 3H), 3.73–3.77(m, 2H), 3.74(s, 3H), 3.87



(s, 3H), 5.16(s, 2H), 5.63(s, 1H), 6.65(s, 1H), 6.90(dd, J=2.1, 8.1



Hz, 1H), 6.96–7.01(m, 3H), 7.04(d, J=2.1Hz, 1H), 7.37–7.48(m,



5H), 7.51–7.56(m, 2H)



IR(KBr)3600–2800(br), 1607, 1518, 1467, 1375, 1288, 1251,



1179, 1113, 1084, 1020, 1008 cm−1


I-252
m.p.111.5–112.5° C.



1HNMR(CDCl3)δ 0.78(t, J=7.5Hz, 3H), 1.15–1.27(m, 2H), 1.41–



1.50(m, 2H), 3.10(s, 3H), 3.61(s, 3H), 3.73–3.78(m, 2H), 3.74(s,



6H), 5.18(s, 2H), 6.66(s, 1H), 6.96–7.01(m, 2H), 7.10(d, J=8.7Hz,



1H), 7.26–7.55(m, 9H)



IR(KBr)3600–2800(br), 1609, 1518, 1464, 1440, 1375, 1355,



1289, 1269, 1249, 1181, 1170, 1107, 1080, 1019 cm−1


I-253
1HNMR(CDCl3)δ 1.76(s, 3H), 1.82(s, 3H), 3.45(s, 3H), 3.76(s,



3H), 4.62(d, J=8.4Hz, 2H), 5.54(t, J=8.4Hz, 1H), 6.49(s, 1H),



6.91–6.99(m, 2H), 7.05(d, J=1.5Hz), 7.74(d, J=8.7Hz, 2H), 8.15(d,



J=8.7Hz, 2H)



IR(KBr)3474, 1687, 1607, 1509, 1417, 1397, 1316, 1287, 1240,



1109, 1071, 1006 cm−1


I-254
1HNMR(CDCl3)δ 2.39(s, 3H), 3.45(s, 3H), 3.76(s, 3H), 5.11(s,



2H), 6.49(s, 1H), 6.94(dd, J=8.4&1.8Hz, 1H), 7.04(d, J=8.4Hz,



1H), 7.06(d, J=1.8Hz), 7.19–7.38(m, 4H), 7.73(d, J=8.4Hz, 2H),



8.14(d, J=8.4Hz, 2H)



IR(KBr)3549, 3466, 1668, 1603, 1518, 1489, 1465, 1449, 1421,



1397, 1372, 1288, 1236, 1186, 1117, 1074, 1017 cm−1


I-255
1HNMR(CDCl3)δ 1.76(s, 3H), 1.82(s, 3H), 3.02(s, 6H), 3.48(s,



3H), 3.74(s, 3H), 4.61(d, J=7.2Hz, 2H), 5.53(t, J=7.2Hz, 1H), 5.66



(s, 1H), 5.92(s, 1H), 6.47(s, 1H), 6.81(broad, 2H), 6.95(s, 2H),



7.06(s, 1H), 7.56(d, J=8.7Hz, 2H)



IR(KBr)3535, 3494, 3452, 1606, 1526, 1487, 1406, 1357, 1288,



1242, 1195, 1112 cm−1


I-256
1HNMR(CDCl3)δ 2.39(s, 3H), 3.02(s, 6H), 3.48(s, 3H), 3.74(s,



3H), 5.10(s, 2H), 5.66(s, 1H), 5.93(s, 1H), 6.47(s, 1H), 6.82(d, J=



8.4Hz, 2H), 6.96(dd, J=8.1&1.8Hz, 1H), 7.02(d, J=8.1Hz, 1H),



7.08 (d, J=1.8Hz, 1H), 7.23(d, J=7.8Hz, 2H), 7.34(d, J=7.8Hz,



2H), 7.56(d, J=8.4Hz, 2H)



IR(KBr)3536, 3379, 1610, 1586, 1528, 1489, 1460, 1443, 1361,



1288, 1250, 1225, 1195, 1117, 1072, 1008 cm−1

















TABLE 55







I-257
1HNMR(CDCl3)δ 1.71(s, 3H), 1.76(s, 3H), 2.49–2.60(m, 2H),



3.44(s, 3H), 3.70(s, 3H), 4.06(t, J=6.3Hz, 2H), 4.48(d, J=6.0Hz,



2H), 4.71 (d, J=8.7Hz, 2H), 5.23(t, J=8.7Hz, 1H), 5.37(broads,



1H), 6.84(s, 1H), 6.91–6.97(m, 1H), 6.92(d, J=8.4Hz, 2H), 7.18–



7.23(m, 2H), 7.52(d, J=8.7Hz, 2H)



IR(KBr)3398, 1612, 1518, 1465, 1389, 1232, 1174, 1131, 1101,



1081, 1023 cm−1


I-258
1HNMR(CDCl3)δ : 3.21(s, 3H), 3.41(s, 3H), 3.63(s, 3H), 3.77(s,



3H), 4.76(s, 2H), 5.15(s, 2H), 6.94(s, 1H), 6.99(d, J=8.7Hz, 1H),



7.23–7.49(m, 9H), 7.71(d, J=8.7Hz, 2H)



IR(KBr)3497, 1738, 1721, 1607, 1509, 1469, 1362, 1242, 1152,



1056, 1017 cm−1


I-259
foam



1HNMR(CDCl3)δ 2.35(s, 6H), 2.73(s, 3H), 2.79(t, J=5.7Hz, 2H),



3.21(s, 3H), 3.31(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 4.19(t, J=5.7Hz,



2H), 6.84(s, 1H), 7.09(d, J=8.4Hz, 1H), 7.34–7.41(m, 4H), 7.66–



7.71(m, 2H)



IR(KBr)3600–2700(br), 1519, 1481, 1365, 1273, 1200, 1177,



1151, 1120, 1079, 1015 cm−1


I-260
foam



1HNMR(CDCl3+CD3OD)δ 2.71(t, J=5.1Hz, 2H), 3.46(s, 6H),



3.73(s, 6H), 4.11(t, J=5.1Hz, 2H), 6.44(s, 1H), 6.87–6.99(m, 4H),



7.04(d, J=2.1Hz, 1H), 7.49–7.53(m, 2H)



IR(KBr)3600–2200(br), 1607, 1583, 1519, 1475, 1407, 1390,



1275, 1252, 1226, 1114, 1062 cm−1


I-261
m.p.85–87° C.



1HNMR(CDCl3)δ 3.49(s, 3H), 3.75(s, 3H), 5.15(s, 2H), 5.23(brs,



1H), 5.68(brs, 1H), 5.89(s, 1H), 6.43(s, 1H), 6.95(dd, J=8.3, 2.1



Hz, 1H), 7.03(d, J=8.3Hz, 1H), 7.08(d, J=2.1Hz, 1H), 7.08(t, J=



8.7Hz, 1H), 7.33(ddd, J=8.7, 2.1, 1.2Hz1H), 7.37–7.47(m, 6H)



IR(KBr)3410, 1525, 1488, 1284, 1248, 1102, 1010, 759, 704 cm−1

















TABLE 56







I-262
m.p.138–140° C.



1HNMR(CDCl3)δ 1.77(s, 3H), 1.82, (s, 3H), 3.21(s, 3H),



3.22(s, 3H), 3.48(s, 3H), 3.78(s, 3H), 4.64(d, J=6.5Hz, 2H),



5.51(t, J=6.5Hz, 1H), 7.05(d, J=8.5Hz, 1H), 7.08(s, 1H),



7.14(dd, J=8.5, 2.2Hz, 1H), 7.34(d, J=2.2Hz, 1H),



7.40(d, J=8.7Hz, 2H), 7.69(d, J=8.7Hz, 2H), 10.00(s, 1H)



IR(KBr)1693, 1514, 1470, 1361, 1348, 1275, 1239, 1175, 1151,



979, 969, 867, 845, 815cm−1


I-263
foam



1HNMR(DMSO-d6)δ 1.74(s, 3H), 1.78(s, 3H), 3.32(s, 3H),



3.44(s, 3H), 3.76(s, 3H), 4.66(d, J=6.6Hz, 2H),



5.49(t, J=6.6Hz, 1H), 7.11(s, 1H), 7.23–7.25(m, 3H),



7.48(d, J=8.6Hz, 2H), 7.77(d, J=8.6Hz, 2H), 13.1(brs, 1H)



IR(KBr)3431, 1737, 1518, 1471, 1177, 1151, 972, 864, 849cm−1


I-264
m.p.153.5–155.5° C.



1HNMR(CDCl3)δ 2.58(s, 3H), 3.52(s, 3H), 3.77(s, 3H),



5.21(s, 2H), 6.83(s, 1H), 7.04–7.24(m, 5H), 7.30–7.49(m, 5H),



7.56–7.65(m, 2H)



IR(CHCl3)1607, 1520, 1481, 1412, 1368, 1298, 1267, 1131,



1080, 1012, 960, 942, 907, 869, 836, 812cm−1


I-265
dp>116° C.



1HNMR(CDCl3+CD3OD)δ 2.69(s, 3H), 3.15(s, 3H), 3.16(s, 3H),



3.57(s, 3H), 3.80(s, 3H), 5.21(s, 2H), 6.88(s, 1H),



7.19(d, J=8.4Hz, 1H), 7.34–7.51(m, 7H), 7.83–7.90(m, 2H),



8.01–8.07(m, 5H)



IR(KBr)3434, 3028, 2934, 1596, 1519, 1460, 1365, 1308, 1276,



1173, 1148, 1119, 1108, 1012, 946, 841, 819cm−1


I-266
m.p.136–138° C.



1HNMR(CDCl3)δ 3.43(s, 3H), 3.75(s, 3H), 5.19(s, 2H),



5.98(s, 1H), 6.44(s, 1H), 7.04–7.52(m, 10H), 7.57–7.65(m, 5H)



IR(CHCl3)3496, 1612, 1521, 1488, 1454, 1412, 1391, 1313,



1267, 1157, 1113, 1069, 1010, 934, 825cm−1

















TABLE 57







I-267
foam



1HNMR(CDCl3)δ 2.38(s, 3H), 3.10(s, 3H), 3.21(s, 3H),



3.41(s, 3H), 3.67(s, 3H), 3.77(s, 3H), 5.11(s, 2H), 6.93(s, 1H),



7.09(d, J=8.6Hz, 1H), 7.21(d, J=8.2Hz, 2H),



7.27(d, J=2.1Hz, 1H), 7.35(d, J=8.2Hz, 2H),



7.38(d, J=8.9Hz, 2H), 7.70(d, J=8.9Hz, 2H)



IR(KBr)1733, 1518, 1471, 1367, 1297, 1177, 1151, 1118, 1059,



971, 862, 815cm−1


I-268
amorphous



1HNMR(DMSO-d6)δ 1.64(s, 3H), 1.70(s, 3H),



2.44(q, J=7.2Hz, 2H), 3.30(s, 3H), 3.70(s, 3H),



3.93(t, J=7.2Hz, 2H), 5.26(t, J=7.2Hz, 1H),



6.64(dd, J=8.6, 2.1Hz, 1H), 6.74(d, J=2.1Hz, 1H),



6.87(d, J=8.9Hz, 2H), 6.87(d, J=8.6Hz, 1H),



6.96(s, 1H), 7.48(d, J=8.9Hz, 2H), 8.84(s, 1H), 9.59(s, 1H),



12.8(brs, 1H)



IR(CHCl3)3594, 3540, 1743, 1707, 1520, 1470, 1260, 1058cm−1


I-269
m.p.206–208° C.(dec.)



1HNMR(DMSO-d6)δ 2.32(s, 3H), 3.32(s, 3H), 3.66(s, 3H),



5.05(s, 2H), 6.66(dd, J=8.2, 2.1Hz, 1H), 6.79(d, J=2.1Hz, 1H),



6.83(s, 1H), 6.84(d, J=8.6Hz, 2H), 6.89(d, J=8.2Hz, 1H),



7.20(d, J=8.0Hz, 2H), 7.38(d, J=8.0Hz, 2H),



7.45(d, J=8.6Hz, 2H), 8.91(s, 1H), 9.68(s, 1H), 12.7(brs, 1H)



IR(KBr)3413, 1710, 1612, 1591, 1520, 1471, 1377, 1227, 1083,



1059, 1013, 837, 809cm−1


I-270
foam



1HNMR(CDCl3)δ 2.42(s, 3H), 3.45(s, 3H), 3.75(s, 3H),



5.15(s, 2H), 5.68(s, 1H), 5.93(s, 1H), 6.47(s, 1H),



6.96(dd, J=1.8, 8.1Hz, 1H), 7.03(d, J=1.8hz, 1H),



7.25–7.28(m, 2H), 7.35–7.48(m, 5H), 7.52–7.56(m, 2H)



IR(CHCl3)3535, 3014, 1616, 1588, 1559, 1523, 1513, 1490,



1463, 1455, 1417, 1396, 1317, 1290, 1247, 1194, 1115, 1072,



1012cm−1


I-271
m.p.143–145° C.



1HNMR(CDCl3)δ 2.70(s, 3H), 3.12(s, 3H), 3.54(s, 3H),



3.73(s, 3H), 3.84(s, 3H), 5.18(s, 2H), 6.83(s, 1H),



7.00–7.07(m, 2H), 7.14(d, J=8.4Hz, 1H), 7.33–7.49(m, 9H)



IR(KBr)3434, 2940, 1609, 1520, 1482, 1396, 1369, 1293, 1243,



1178, 1114, 1080, 1021, 1009cm−1

















TABLE 58







I-272
foam



1HNMR(CDCl3)δ 3.45(s, 3H), 3.71(s, 3H), 3.86(s, 3H),



5.15(s, 2H), 5.67(s, 1H), 5.84(s, 1H), 6.42(s, 1H),



6.98(dd, J=1.8, 8.4Hz, 1H), 7.01–7.07(m, 2H),



7.11(d, J=1.8Hz, 1H), 7.35–7.45(m, 8H)



IR(CHCl3)3534, 3024, 1617, 1587, 1517, 1503, 1483, 1462,



1409, 1290, 1247, 1226, 1215, 1122, 1104, 1072, 1013cm−1


I-273
m.p.155–156° C.



1HNMR(CDCl3)δ 1.76(s, 3H), 1.81(s, 3H), 2.42(s, 3H),



2.73(s, 3H), 3.23(s, 3H), 3.53(s, 3H), 3.77(s, 3H),



4.63(d, J=6.6Hz, 2Hz), 5.49(m, 1H), 6.86(s, 1H),



7.09(d, J=8.4Hz, 1H), 7.25–7.53(m, 6H)



IR(KBr)3434, 2935, 1605, 1522, 1465, 1388, 1365, 1292, 1273,



1176, 1119, 1084, 1011cm−1


I-274
m.p.138–140° C.



1HNMR(CDCl3)δ 1.76(s, 3H), 1.81(s, 3H), 2.73(s, 3H),



3.22(s, 3H), 3.54(s, 3H), 3.73(s, 3H), 3.84(s, 3H),



4.63(d, J=6.9Hz, 2H), 5.50(m, 1H), 6.83(s, 1H),



7.01–7.04(m, 2H), 7.08(d, J=8.4Hz, 1H), 7.26(d, J=0.6Hz, 1H),



7.34–7.43(m, 3H)



IR(KBr)3433, 2937, 1608, 1519, 1480, 1400, 1368, 1292, 1271,



1244, 1179, 1112, 1081, 1011cm−1


I-275
m.p.95–97° C.



1HNMR(CDCl3)δ 1.76(s, 3H), 1.82(s, 3H), 2.42(s, 3H),



3.45(s, 3H), 3.74(s, 3H), 4.61(d, J=6.6Hz, 2H), 5.52(m, 1H),



5.69(s, 1H), 6.47(s, 1H), 6.95–7.07(m, 3H), 7.25–7.28(m, 2H),



7.52–7.55(m, 2H)



IR(KBr)3479, 2935, 1613, 1585, 1523, 1509, 1490, 1458, 1415,



1395, 1362, 1315, 1249, 1196, 1112, 1070, 1005cm−1


I-276
m.p.155–158° C.



1HNMR(CDCl3)δ 1.76(d, J=0.9Hz, 3H),



1.82(d, J=0.9Hz, 3H), 3.45(s, 3H), 3.86(s, 3H),



4.61(d, J=6.9Hz, 2H), 5.35(m, 1H), 5.68(s, 1H),



5.82(s, 1H), 6.42(s, 1H), 6.96–7.09(m, 4H), 7.35–7.41(m, 2H)



IR(KBr)3428, 3005, 2952, 1613, 1583, 1517, 1505, 1487, 1464,



1451, 1411, 1387, 1359, 1317, 1289, 1245, 1140, 1101, 1070,



1013cm−1

















TABLE 59







I-277
m.p.173–175° C.



1HNMR(CDCl3)δ 1.68(s, 3H), 1.74(s, 3H), 2.42(s, 3H),



2.51–2.60(m, 2H), 2.75(s, 3H), 3.21(s, 3H), 3.53(s, 3H),



3.76(s, 3H), 4.07(t, J=6.9Hz, 2H), 5.21(m, 1H), 6.86(s, 1H),



7.06(d, J=8.7Hz, 1H), 7.25–7.28(m, 2H),



7.35(dd, J=2.1, 8.7Hz, 1H), 7.40(d, J=2.1Hz, 1H),



7.50–7.53(m, 2H)



IR(KBr)3434, 2934, 1606, 1523, 1482, 1388, 1369, 1277, 1236,



1177, 1118, 1085, 1012cm−1


I-278
m.p.151–154° C.



1HNMR(CDCl3)δ 1.69(s, 3H), 1.74(d, J=0.9Hz, 3H),



2.51–2.59(m, 2H), 2.75(s, 3H), 3.21(s, 3H), 3.54(s, 3H),



3.73(s, 3H), 3.84(s, 3H), 4.07(t, J=6.9Hz, 2H), 5.21(m, 1H),



6.83(s, 1H), 7.00–7.08(m, 3H), 7.34–7.43(m, 4H)



IR(KBr)3434, 2935, 1610, 1581, 1522, 1479, 1399, 1362, 1283,



1246, 1180, 1125, 1114, 1082, 1046cm−1


I-279
m.p.90–92° C.



1HNMR(CDCl3)δ 1.69(s, 3H), 1.75(s, 3H), 2.42(s, 3H),



2.49–2.56(m, 2H), 3.45(s, 3H), 3.74(s, 3H), 4.06(t, J=6.6Hz, 2H),



5.22(m, 1H), 5.67(s, 1H), 5.90(s, 1H), 6.46(s, 1H),



6.94–7.06(m, 3H), 7.25–7.28(m, 2H), 7.52–7.55(m, 2H)



IR(KBr)3529, 3381, 2927, 1616, 1586, 1522, 1490, 1465, 1418,



1398, 1360, 1315, 1289, 1251, 1225, 1192, 1114, 1070, 1011cm−1


I-280
m.p.82–84° C.



1HNMR(CDCl3)δ 1.69(s, 3H), 1.75(s, 3H),



2.49–2.56(m, 2H), 3.45(s, 3H), 3.71(s, 3H), 3.85(s, 3H),



4.06(t, J=6.6Hz, 2H), 5.22(m, 1H), 5.67(s, 1H), 5.82(s, 1H),



6.42(s, 1H), 6.92–7.09(m, 5H), 7.35–7.43(m, 2H)



IR(KBr)3420, 3326, 2935, 1615, 1583, 1518, 1504, 1486, 1466,



1410, 1316, 1289, 1249, 1122, 1101, 1071, 1018cm−1


I-281
m.p.166–168° C.



1HNMR(CDCl3)δ 2.38(s, 3H), 2.69(s, 3H),



3.11(s, 3H), 3.54(s, 3H), 3.73(s, 3H), 3.84(s, 3H), 5.14(s, 2H),



6.83(s, 1H), 7.00–7.44(m, 11H)



IR(KBr)3434, 2941, 1608, 1521, 1498, 1482, 1466, 1397, 1368



1284, 1243, 1177, 1113, 1079, 1019cm−1

















TABLE 60







I-282
m.p. 109–111° C.



1HNMR(CDCl3)δ 2.39(s, 3H), 3.45(s, 3H), 3.71(s, 3H), 3.85(s,



3H), 5.10(s, 2H), 5.67(s, 1H), 5.83(s, 1H), 6.42(s, 1H), 6.95–



7.41(m, 11H)



IR(CHCl3)3497, 2935, 1610, 1583, 1519, 1499, 1481, 1465,



1399, 1312, 1274, 1245, 1185, 1120, 1102, 1067, 1012 cm−1


I-283
1HNMR(CDCl3)δ 2.38(s, 3H), 2.68(s, 3H), 3.12(s, 3H),



3.53(s, 1H), 3.77(s, 3H), 5.14(s, 2H), 6.83(s, 1H), 7.10–7.24



(m, 5H), 7.33(d, J=8.4Hz, 1H), 7.34(d, J=8.4Hz, 2H), 7.40(d,



J=2.1Hz, 1H), 7.56–7.64(m, 2H)



IR(KBr)1603, 1520, 1482, 1367, 1297, 1277, 1251, 1232, 1176,



1120, 1084, 1012 cm−1


I-284
1HNMR(CDCl3)δ 2.39(s, 3H), 3.45(s, 3H), 3.75(s, 3H), 5.10



(s, 2H), 5.68(s, 1H), 5.88(s, 1H), 6.44(s, 1H), 6.95(dd, J=



8.4&2.1Hz, 1H) 7.03(d, J=8.4Hz, 1H), 7.07(d, J=2.1Hz, 1H),



7.08–7.29(m, 4H), 7.34(d, J=8.4Hz, 2H), 7.56–7.65(m, 2H)s



IR(KBr)3504, 3330, 1604, 1596, 1490, 1461, 1455, 1424, 1360,



1318, 1242, 1223, 1121, 1071, 1009 cm−1


I-285
1HNMR(CDCl3)δ 2.69(s, 3H), 3.13(s, 3H), 3.56(s, 3H),



3.78(s, 3H), 5.19(s, 2H), 6.85(s, 1H), 7.05–7.15(m, 1H),



7.15(d, J=8.4Hz, 1H), 7.30–7.49(m, 10H)



IR(KBr)1610, 1583, 1517, 1475, 1455, 1359, 1296, 1270, 1239,



1180, 1116, 1088, 1013 cm−1


I-286
1HNMR(CDCl3)δ 3.47(s, 3H), 3.75(s, 3H), 5.15(s, 2H), 5.68(s,



1H), 5.89(s, 1H), 6.46(s, 1H), 6.95(dd, J=8.4&2.1Hz, 1H),



7.03(d, J=8.4Hz, 1H), 7.04–7.12(m, 2H), 7.35–7.51(m, 9H)



IR(KBr)3543, 3346, 1612, 1586, 1566, 1518, 1502, 1479, 1407,



1362, 1320, 1239, 1110, 1068 1006 cm−1


I-287
1HNMR(CDCl3)δ 2.68(s, 3H), 3.14(s, 3H), 3.58(s, 3H), 3.81(s,



3H), 5.20(s, 2H), 6.88(s, 1H), 7.16(d, J=8.7Hz, 1H), 7.32–



7.49(m, 7H), 7.60–7.68(m, 1H), 7.98–8.04(m, 1H), 8.24–8.29



(m, 1H), 8.44–8.47(m, 1H)



IR(KBr)1609, 1531, 1362, 1270, 1239, 1178, 1122, 1085,



1014 cm−1


I-288
1HNMR(CDCl3)δ 3.49(s, 3H), 3.78(s, 3H), 5.17(s, 2H), 5.71(s,



1H), 5.83(s, 1H), 6.49(s, 1H), 6.95(dd, J=12.3&1.2Hz, 1H),



7.02 (d, J=12.3Hz, 1H), 7.08(d, J=1.2Hz, 1H), 7.33–7.50



(m, 5H), 7.60–7.68(m, 1H), 7.97–8.06(m, 1H), 8.21–



8.27(m, 1H), 8.52(s, 1H)



IR(KBr)3528, 3358, 1588, 1527, 1499, 1454, 1406, 1348, 1314,



1241, 1122, 1070, 1009 cm−1

















TABLE 61







I-289
1HNMR(CDCl3)δ 2.68(s, 3H), 3.13(s, 3H), 3.55(s, 3H),



3.77(s, 3H), 5.19(s, 2H), 6.79–6.88(m, 1H), 6.86(s, 1H), 7.02–



7.10(m, 2H), 7.15(d, J=8.4Hz, 1H), 7.26–7.50(m, 8H)



IR(KBr)3479, 3388, 1623, 1603, 1518, 1478, 1396, 1358, 1176,



1118, 1081, 1013 cm−1


I-290
1HNMR(CDCl3)δ 3.11(s, 3H), 3.45(s, 3H), 3.77(s, 3H), 5.17(s,



2H), 6.05(s, 1H), 6.46(s, 1H), 7.00–7.18(m, 1H), 7.14(d,



J=8.4Hz, 1H), 7.33–7.50(m, 9H), 7.52(d, J=2.1Hz, 1H)



IR(KBr)3504, 1612, 1578, 1519, 1498, 1464, 1391, 1355, 1290,



1276, 1239, 1183, 1167, 1107, 1070, 1004 cm−1


I-291
1HNMR(CDCl3+CD3OD)δ 3.44(s, 3H), 3.75(s, 3H), 4.74(s,



2H), 5.13(s, 2H), 6.86–6.95(m, 3H), 6.99(d, J=8.7Hz, 1H)



7.30–7.48(m, 7H), 7.52(d, J=8.7Hz, 2H)



IR(KBr)3433, 1707, 1611, 1518, 1473, 1463, 1379, 1250, 1174,



1132, 1089, 1058, 1016 cm−1


I-292
1HNMR(CDCl3+CD3OD)δ 3.41(s, 3H), 3.62(s, 3H), 3.75(s,



3H), 4.74(s, 2H), 5.15(s, 2H), 6.87–7.01(m, 4H), 7.30–7.55(m,



9H)



IR(KBr)3386, 1722, 1611, 1518, 1464, 1343, 1271, 1245, 1233,



1215, 1168, 1082, 1060, 1021 cm−1


I-293
1HNMR(CDCl3)δ 2.38(s, 3H), 2.69(s, 3H), 3.12(s, 3H), 3.56(s,



3H), 3.78(s, 3H), 5.14(s, 2H), 6.85(s, 1H), 7.05–7.45(m, 12H)



IR(KBr)1607, 1584, 1519, 1479, 1401, 1364, 1348, 1280, 1237,



1178, 1164, 1115, 1081, 1016 cm−1


I-294
foam



1HNMR(CDCl3)δ 3.45(s, 3H), 3.75(s, 3H), 4.36(d, J=2.1Hz,



1H), 4.55(s, 2H), 4.76(d, J=2.1Hz, 1H), 6.45(s, 1H), 6.92(d,



J=8.7Hz, 2H), 6.99(d, J=8.4Hz, 1H), 7.20(dd, J=1.5and



8.4Hz, 1H), 7.11(d, J=1.5Hz, 1H), 7.53(d, J=8.7Hz, 2H)



IR(Nujol)3425, 1612, 1588, 1523, 1487, 1295, 1268, 1228,



1113, 1069, 825 cm−1


I-295
foam



1HNMR(CDCl3)δ 2.78(s, 3H), 3.21(s, 3H), 3.23(s, 3H), 3.55



(s, 3H), 3.78(s, 3H), 4.79(d, J=6.6Hz, 2H), 6.21(t, J=6.6Hz,



1H), 6.85(s, 1H), 7.08(d, J=8.7Hz, 1H), 7.37(dd, J=8.7, 2.1Hz,



1H), 7.38(d, J=8.7Hz, 2H), 7.41(d, J=2.1Hz, 1H), 7.68(d,



J=8.7Hz, 2H)



IR(Nujol)1632, 1607, 1519, 1482, 1180, 1150, 1079, 1011,



976, 876, 814, 798 cm−1

















TABLE 62







I-296
foam



1HNMR(CD3OD)δ 3.38(s, 3H), 3.68(s, 3H), 4.12(brs, 2H),



4.65(brs, 2H), 5.01(m, 2H), 6.43(s, 1H),



6.78(dd, J=8.7, 1.8Hz, 1H), 6.85(d, J=8.7, 2H),



6.86(d, J=1.8Hz, 1H), 6.94(d, J=8.4Hz, 1H),



7.46(d, J=8.7Hz, 2H)



IR(Nujol)3411, 1612, 1591, 1520, 1485, 1461, 1253, 1223, 1115,



1008, 971, 944, 842, 810, 785cm−1


I-297
foam



1HNMR(CD3OD)δ 3.38(s, 3H), 3.68(s, 3H),



4.73(d, J=5.1Hz, 2H), 4.23(d, J=5.1Hz, 2H), 5.83(m, 2H),



6.43(s, 1H), 6.79(dd, J=8.7, 1.8Hz, 1H), 6.85(d, J=8.7, 2H),



6.86(d, J=1.8Hz, 1H), 6.94(d, J=8.7Hz, 2H)



IR(Nujol)3393, 1611, 1588, 1523, 1489, 1460, 1248, 1114, 1071,



1013, 940, 824cm−1


I-298
foam



1HNMR(CD3OD)δ 1.77(s, 3H), 3.38(s, 3H), 3.68(s, 3H),



4.00(s, 2H), 5.72(d, J=6.3Hz, 2H), 5.81(t, J=6.3Hz, 1H),



6.43(s, 1H), 6.79(dd, J=8.7, 1.8Hz, 1H), 6.85(d, J=8.7, 2H),



6.85(d, J=1.8Hz, 1H), 6.94(d, J=8.4Hz, 1H),



7.46(d, J=8.7Hz, 2H)



IR(Nujol)3384, 1608, 1585, 1523, 1494, 1457, 1262, 1242, 1227,



1116, 1078, 1008, 985, 822, 781cm−1


I-299
foam



1HNMR(CD3OD)δ 1.87(s, 3H), 3.83(s, 3H), 3.68(s, 3H),



4.17(s, 2H), 4.69(d, J=6.6Hz, 2H), 5.68(t, J=6.3Hz, 1H),



6.43(s, 1H), 6.79(dd, J=8.7, 1.8Hz, 1H), 6.85(d, J=8.4, 2H),



6.85(d, J=1.8Hz, 1H), 6.94(d, J=8.4Hz, 1H),



7.46(d, J=8.7Hz, 2H)



IR(Nujol)3350, 3236, 1606, 1589, 1524, 1490, 1463, 1247, 1227,



1079, 1011, 992, 819, 790cm−1


I-300
foam



1HNMR(CDCl3)δ 1.87(s, 3H), 2.10(s, 3H), 3.45(s, 3H),



3.74(s, 3H), 4.68(s, 2H), 4.71(d, J=6.0Hz, 2H),



5.77(t, J=6.0Hz, 1H), 6.44(s, 1H), 6.92(d, J=8.0Hz, 2H),



6.95(m, 2H), 7.07(brs, 1H), 7.53(d, J=6.0Hz, 2H)



IR(Nujol)3409, 1724, 1612, 1587, 1523, 1489, 1460, 1239, 1114,



1071, 1012, 940, 825, 781cm−1

















TABLE 63







I-301
foam



1HNMR(CD3OD)δ 2.93(d, J=2.1Hz, 1H), 3.38(s, 3H),



3.68(s, 3H), 4.06(dd, J=9.9, 7.8Hz, 1H),



4.20(dd, J=9.9, 3.6Hz, 1H), 4.74(ddd, J=7.8, 3.6, 2.1Hz, 1H),



6.44(s, 1H), 6.80(dd, J=8.4, 1.8Hz, 1H), 6.85(d, J=8.7, 2H),



6.87(d, J=1.8Hz, 1H), 6.96(d, J=8.4Hz, 1H),



7.46(d, J=8.7Hz, 2H)



IR(Nujol)3282, 1655, 1612, 1588, 1523, 1489, 1460, 1254, 1226,



1072, 1013, 940, 825cm−1


I-302
foam



1HNMR(CD3OD)δ 3.30(s, 3H), 3.68(s, 3H),



4.75(d, J=5.1Hz, 2H), 6.44(s, 1H), 6.80(dd, J=8.4, 1.8Hz, 1H),



6.85(d, J=8.4, 2H), 6.92(d, J=1.8Hz, 1H), 6.99(d, J=8.7Hz, 1H),



7.42(t, J=5.1Hz, 1H), 7.46(d, J=8.4Hz, 2H)



IR(Nujol)3474, 3316, 1678, 1611, 1584, 1523, 1487, 1458, 1268,



1231, 1115, 1171, 1011, 942, 824, 758cm−1


I-303
foam



1HNMR(CD3OD)δ 1.24(d, J=7.2Hz, 3H),



3.38(s, 3H), 3.68(s, 3H), 4.12(q, J=7.2Hz, 2H),



4.75(d, J=4.8Hz, 2H), 6.43(s, 1H), 6.80(dd, J=8.4, 1.8Hz, 1H),



6.85(d, J=8.7, 2H), 6.91(d, J=1.8Hz, 1H), 6.99(d, J=8.4Hz, 2H),



7.46(d, J=8.7Hz, 2H), 7.52(t, J=4.8Hz, 1H)



IR(Nujol)3306, 1715, 1612, 1587, 1523, 1487, 1460, 1266, 1232,



1115, 1070, 824, 760cm−1


I-304
foam



1HNMR(CDCl3)δ 2.34(s, 3H), 2.38(s, 3H), 2.70(s, 3H),



3.07(s, 3H), 3.21(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 5.13(s, 2H),



6.84(s, 1H), 7.03(d, J=7.8Hz, 1H), 7.06(s, 1H),



7.18(d, J=8.4Hz, 1H), 7.28d, J=7.8Hz, 1H),



7.36(dd, J=2.1, 8.4Hz, 1H), 7.38(d, J=8.7Hz, 2H),



7.40(d, J=2.1Hz, 1H), 7.68(d, J=8.7Hz, 2H)



IR(KBr)1611, 1518, 1480, 1365, 1177, 1151, 1080, 876, 816cm−1


I-305
foam



1HNMR(CDCl3)δ 1.25(d, J=6.9Hz, 6H), 2.67(s, 3H),



2.93(q, J=6.9Hz, 1H)3.13(s, 3H), 3.21(s, 3H), 3.56(s, 3H),



3.78(s, 3H), 5.15(s, 2H), 6.84(s, 1H), 7.16(d, J=8.7Hz, 1H),



7.26(d, J=8.4Hz, 2H), 7.34(dd, J=2.4, 8.7Hz, 1H),



7.38(d, J=8.4Hz, 4H), 7.40(d, J=2.4Hz, 1H),



7.68(d, J=8.4Hz, 2H)



IR(KBr)1609, 1519, 1481, 1365, 1177, 1151, 1080, 875, 819cm−1

















TABLE 64







I-306
foam



1HNMR(CDCl3)δ 2.62(s, 3H), 3.15(s, 3H), 3.21(s, 3H),



3.55(s, 3H), 3.77(s, 3H), 5.36(s, 2H), 6.84(s, 1H),



7.18(d, J=8.7Hz, 1H), 7.26(s, 1H), 7.33(dd, J=2.1, 8.4Hz, 1H),



7.38(d, J=8.7Hz, 2H), 7.41(d, J=2.1Hz, 1H), 7.51(m, 2H),



7.57(dd, J=1.8, 8.4Hz, 1H), 7.68(d, J=8.7Hz, 2H),



7.84–7.93(m, 4H)



IR(KBr)1608, 1519, 1480, 1364, 1177, 1151, 1079, 876, 819,



797cm−1


I-307
foam



1HNMR(CDCl3)δ 2.64(s, 3H), 3.21(s, 3H), 3.28(s, 3H),



3.55(s, 3H), 3.77(s, 3H), 5.51(s, 2H), 6.83(s, 1H),



7.18(d, J=8.4Hz, 1H), 7.31(dd, J=2.4, 8.4Hz, 1H),



7.37(d, J=8.7Hz, 2H), 7.42(d, J=2.4Hz, 1H),



7.58(dt, J=2.4, 7.2Hz, 1H), 7.67(d, J=8.7Hz, 2H),



7.74(d, J=8.4Hz, 1H), 7.76(dt, J=2.4, 7.2Hz, 1H),



7.85(d, J=7.2Hz, 1H), 8.06(d, J=7.2Hz, 1H),



8.23(d, J=7.2Hz, 1H)



IR(KBr)1603, 1519, 1480, 1365, 1177, 1151, 1080, 876, 824,



797cm−1


I-308
foam



1HNMR(CDCl3)δ 2.76(s, 3H), 3.17(s, 3H), 3.21(s, 3H),



3.55(s, 3H), 3.78(s, 3H), 5.25(s, 2H), 6.85(s, 1H),



7.12(d, J=8.7Hz, 1H), 7.35(dd, J=2.1, 8.4Hz, 1H),



7.38(d, J=8.7Hz, 2H), 7.42(d, J=2.1Hz, 1H),



7.61(d, J=8.7Hz, 2H), 7.67(d, J=8.4Hz, 2H),



7.68(d, J=8.7Hz, 2H)



IR(KBr)1610, 1522, 1489, 1402, 1245, 1181, 1164, 1110, 1071,



821, 805cm−1


I-309
m.p.221–222° C.



1HNMR(CDCl3)δ 2.36(s, 3H), 2.38(s, 3H), 3.46(s, 3H),



3.75(s, 3H), 5.09(s, 2H), 6.45(s, 1H), 6.92(d, J=8.4Hz, 2H),



6.98(dd, J=2.1, 8.1Hz, 1H), 7.06(d, J=8.4Hz, 1H),



7.08(d, J=2.1Hz, 1H), 7.08(2. 1H), 7.28(d, J=8.4Hz, 1H),



7.53(d, J=8.4Hz, 1H), 7.53(d, J=8.4Hz, 2H)



IR(KBr)3475, 1610, 1522, 1489, 1402, 1245, 1181, 1164, 1110,



1071, 821, 805cm−1


I-310
m.p.153–155° C.



1HNMR(CDCl3)δ 1.27(d, J=6.9Hz, 6H), 2.95(q, J=6.9Hz, 1H),



3.45(s, 3H), 3.74(s, 3H), 5.11(s, 2H), 6.45(s, 1H),



6.91(d, J=8.4Hz, 2H), 6.96(dd, J=2.1, 8.1Hz, 1H),



7.03(d, J=8.1Hz, 1H), 7.08(d, J=2.1Hz, 1H),



7.28(d, J=8.1Hz, 2H), 7.38(d, J=8.1Hz, 2H),



7.53(d, J=8.4Hz, 2H)



IR(KBr)3486, 1611, 1522, 1489, 1265, 1113, 1072, 1011,



823cm−1

















TABLE 65







I-311
m.p.176–177° C.



1HNMR(CDCl3)δ 3.45(s, 3H), 3.75(s, 3H), 5.32(s, 2H),



6.45(s, 1H), 6.91(d, J=8.4Hz, 2H), 6.97(dd, J=2.1, 8.4Hz, 1H),



7.06(d, J=8.4Hz, 1H), 7.10(d, J=2.1Hz, 1H),



7.53(d, J=8.4Hz, 2H), 7.50–7.57(m, 3H), 7.82–7.92(m, 4H)



IR(KBr)3476, 1610, 1522, 1488, 1469, 1401, 1263, 1246, 1173,



1112, 1073, 1014, 1002, 819, 806cm−1


I-312
m.p.235–237° C.



1HNMR(CDCl3)δ 3.44(s, 3H), 3.73(s, 3H), 5.49(s, 2H),



6.44(s, 1H), 6.92(d, J=8.4Hz, 2H), 6.93(dd, J=2.1, 8.4Hz, 1H),



7.14(d, J=2.1Hz, 1H), 7.18(d, J=8.4Hz, 1H),



7.38(d, J=8.4Hz, 1H), 7.52(d, J=8.4Hz, 2H),



7.58(dd, J=7.2, 7.2Hz, 1H), 7.77(dd, J=7.2, 7.2Hz, 1H),



7.85(d, J=7.2Hz, 1H), 8.21(d, J=7.2Hz, 1H),



8.22(d, J=7.2Hz, 1H)



IR(KBr)3378, 1609, 1522, 1488, 1268, 1229, 1205, 1114, 1072,



1016, 825, 782cm−1


I-313
m.p.159–161° C.



1HNMR(CDCl3)δ 3.45(s, 3H), 3.75(s, 3H), 5.22(s, 2H),



6.45(s, 1H), 6.92(d, J=8.4Hz, 2H), 6.96(br.s, 2H), 7.11(br.s, 1H),



7.53(d, J=8.4Hz, 2H), 7.57(d, J=8.4Hz, 2H),



7.68(d, J=8.4Hz, 2H),



IR(KBr)3433, 1613, 1523, 1490, 1326, 1251, 1166, 1113, 1066,



1014, 825, cm−1


I-314
m.p.92–93° C.



1HNMR(CDCl3)δ 1.63(s, 3H), 1.74(s, 3H), 2.34–2.39(m, 1H),



2.67–2.72(m, 2H), 3.47(s, 3H), 3.74(s, 3H), 4.52–4.54(m, 2H),



5.30–5.33(m, 2H), 6.78–6.97(m, 4H), 7.20(d, J=7.2Hz, 1H),



7.56(d, J=8.0Hz, 2H)



IR(KBr)3410, 2932, 1613, 1519, 1473, 1444, 1390, 1263, 1228,



1174cm−1


I-315
m.p.85–86° C.



1HNMR(CDCl3)δ 1.76(s, 3H), 1.83(s, 3H), 2.17–2.40(m, 1H),



2.65–2.71(m, 2H), 3.24(s, 3H), 3.46(s, 3H), 3.80(s, 3H),



4.50–4.52(m, 2H), 6.70(s, 1H), 7.28–7.43(m, 5H),



7.73(d, J=8.6Hz, 2H)



IR(KBr)3432, 2938, 1731, 1513, 1469, 1366, 1180, 1151, 970,



868cm−1

















TABLE 66







I-316
m.p.179–180° C.



1HNMR(CDCl3)δ 1.72(s, 3H), 1.76(s, 3H), 2.15–2.35(m, 1H),



2.61–2.70(m, 2H), 3.46(s, 3H), 3.76(s, 3H), 4.47–4.50(m, 2H),



6.68(s, 1H), 7.17–7.52(m, 5H), 7.69(d, J=8.4Hz, 2H)



IR(KBr)3427, 2934, 1612, 1576, 1519, 1465, 1443, 1415, 1376,



1228, 1174, 846cm−1


I-317
m.p.141–142° C.



1HNMR(CDCl3)δ 1.75(s, 3H), 1.80(s, 3H), 3.21(s, 3H),



3.39(s, 3H), 3.68(s, 3H), 3.77(s, 3H), 4.61(d, J=7.2Hz, 2H),



5.50(t, J=7.0Hz, 1H), 6.93(s, 1H), 6.99–7.33(m, 5H),



7.57–7.65(m, 2H)



IR(KBr)3432, 2938, 1724, 1519, 1474, 1365, 1346, 1294, 1262,



1244, 1220, 1163, 1119, 1059, 953, 842, 805cm−1


I-318
m.p.127–128° C.



1HNMR(CDCl3)δ 1.68(s, 3H), 1.74(s, 3H),



2.54(dt, J=4.2, 4.6Hz, 2H), 3.20(s, 3H), 3.39(s, 3H), 3.68(s, 3H),



3.76(s, 3H), 4.05(t, J=4.4Hz, 2H), 5.21(t, J=4.6Hz, 1H),



6.93(s, 1H), 7.00(d, J=5.6Hz, 1H), 7.11–7.18(m, 2H),



7.25–7.35(m, 3H), 7.61(dd, J=3.8, 5.8Hz)



IR(KBr)3447, 2974, 2940, 1740, 1519, 1471, 1365, 1343, 1295,



1262, 1226, 1182, 1161, 1119, 1058, 952, 843, 814cm−1


I-319
m.p.171–172° C.



1HNMR(CDCl3)δ 2.38(s, 3H), 3.10(s, 3H), 3.39(s, 3H),



3.66(s, 3H), 3.77(s, 3H), 5.11(s, 3H), 6.93(s, 1H),



7.07–7.36(m, 9H), 7.61(dd, J=3.4, 5.6Hz, 2H)



IR(KBr)3431, 2937, 1724, 1519, 1474, 1440, 1346, 1296, 1259,



1243, 1222, 1165, 1121, 1060, 953, 843, 804cm−1


I-320
m.p.155–156° C.



1HNMR(CDCl3)δ 3.40(s, 3H), 3.69(s, 3H), 3.77(s, 3H),



5.13(s, 2H), 5.70(brs, 1H), 6.82–7.42(m, 5H), 7.39–7.42(m, 5H),



7.62(dd, J=5.4, 8.6Hz)



IR(KBr)3550, 3481, 2956, 1723, 1519, 1467, 1435, 1344, 1285,



1261, 1238, 1223, 1130, 1058, 1013, 840cm−1

















TABLE 67







I-321
m.p.159–160° C.



1HNMR(CDCl3)δ 3.11(s, 3H), 3.40(s, 3H), 3.66(s, 3H),



3.77(s, 3H), 5.16(s, 2H), 6.93(s, 1H), 7.07–7.49(m, 5H),



7.62(dd, J=3.0, 8.4Hz, 2H)



IR(KBr)3441, 2952, 1732, 1519, 1469, 1445, 1381, 1356, 1342,



1291, 1273, 1243, 1226, 1162, 1119, 1081, 1057, 999, 950, 842,



805cm−1


I-322
m.p.160–161° C.



1HNMR(CDCl3)δ 2.37(s, 3H), 2.93(s, 3H), 3.19(s, 3H),



3.22(s, 3H), 3.55(s, 2H), 3.79(s, 3H), 5.23(s, 2H), 6.86(s, 1H),



7.20(d, J=8.1Hz, 2H), 7.30(d, J=8.1Hz, 2H), 7.36–7.41(m, 2H),



7.64–7.70(m, 2H), 7.74(d, J=2.1Hz, 1H), 7.83(d, J=2.1Hz, 1H),



10.16(s, 1H)



IR(CHCl3)3027, 2940, 1692, 1473, 1373, 1227, 1152, 1085cm−1


I-323
powder



1HNMR(CDCl3)δ 2.37(s, 3H), 2.86(s, 3H), 3.13(s, 3H),



3.21(s, 3H), 3.54(s, 3H), 3.79(s, 3H), 4.64(s, 2H), 5.11(s, 2H),



6.85(s, 1H), 7.21(d, J=7.8Hz, 2H), 7.32–7.44(m, 6H),



7.65–7.70(m, 2H)



IR(CHCl3)3026, 2939, 1475, 1372, 1228, 1178, 1151, 1084cm−1


I-324
powder



1HNMR(CDCl3)δ 1.89–1.98(brs, 1H), 2.39(s, 3H), 3.45(s, 3H),



3.75(s, 3H), 4.77(s, 2H), 5.01(s, 3H), 5.46(s, 1H), 5.99(s, 1H),



6.45(s, 1H), 6.45–6.95(m, 2H), 7.05(s, 2H),



7.24(d, J=8.1Hz, 2H), 7.38(d, J=8.1Hz, 2H), 7.50–7.56(m, 2H)



IR(CHCl3)3514, 2937, 1731, 1613, 1522, 1484, 1403, 1228,



1173, 1082cm−1


I-325
powder



1HNMR(CDCl3)δ 2.31(s, 3H), 2.88(s, 3H), 3.07(s, 3H),



3.22(s, 3H), 3.51(s, 2H), 3.74(s, 3H), 5.23(s, 2H), 6.83(s, 1H),



7.11–7.18(m, 2H), 7.32–7.41(m, 4H), 7.62–7.68(m, 3H),



8.03(s, 1H)



IR(CHCl3)3026, 2939, 1742, 1472, 1374, 1227, 1279, 1129,



1085cm−1

















TABLE 68







I-326
powder



1HNMR(CD3OD)δ 2.33(s, 3H), 3.38(s, 3H), 3.68(s, 3H),



5.11(s, 2H), 6.44(s, 1H), 6.82–6.88(m, 2H),



6.99(d, J=1.8Hz, 1H), 7.13–7.19(m, 3H), 7.42–7.50(m, 4H)



IR(KBr)3411, 2935, 1680, 1611, 1520, 1457, 1404, 1281, 1230,



1114cm−1


I-327
powder



1HNMR(CDCl3)δ 1.72(s, 3H), 1.79(s, 3H), 3.12(s, 3H),



3.21(s, 3H), 3.27(s, 3H), 3.52(s, 3H), 3.53(s, 3H),



4.81(d, J=7.5Hz, 2H), 5.51(m, 1H), 7.38–7.43(m, 2H),



7.45–7.50(m, 2H), 7.80(d, J=2.1Hz, 1H), 7.97(d, J=2.1Hz, 1H)



IR(CHCl3)3032, 2941, 1543, 1377, 1209cm−1


I-328
m.p.205–206° C.



1HNMR(CDCl3)δ 1.75(s, 3H), 1.80(s, 3H), 3.41(s, 3H),



3.47(s, 3H), 4.66(d, J=6.6Hz, 2H), 5.06(s, 1H), 5.53(m, 1H),



6.33(s, 1H), 6.89–6.95(m, 2H), 7.28–7.34(m, 2H),



7.38–7.40(m, 1H), 7.99(d, J=2.1Hz, 1H), 10.83(d, J=0.6Hz, 1H)



IR(KBr)3476, 2940, 1614, 1532, 1371, 1238, 1094, 1035cm−1


I-329
m.p.144–145° C.



1HNMR(CDCl3)δ 2.83(s, 3H), 3.22(s, 3H), 3.28(s, 3H),



3.55(s, 3H), 3.79(s, 3H), 6.86(s, 1H), 7.37–7.45(m, 3H),



7.47–7.53(m, 3H), 7.65–7.70(m, 2H)



IR(KBr)3434, 3019, 2939, 1515, 1480, 1370, 1176, 1150,



1081cm−1


I-330
amorphous



1HNMR(CDCl3)δ 1.68(s, 3H), 1.74(s, 3H), 2.54(q, J=7.2Hz, 2H),



3.21(s, 3H), 3.41(s, 3H), 3.65(s, 3H), 3.77(s, 3H),



4.03(t, J=7.2Hz, 2H), 5.23(t, J=7.2Hz, 1H), 6.94(s, 1H),



6.98(t, J=8.6Hz, 1H), 7.05(ddd, J=8.6, 2.1, 0.9Hz, 1H),



7.14(dd, J=12.0, 2.1Hz, 1H), 7.38(d, J=8.7Hz, 2H),



7.71(d, J=8.7Hz, 1H)



IR(CHCl3)1732, 1521, 1471, 1375, 1262, 1230, 1150, 1061,



874cm−1

















TABLE 69







I-331
m.p.146–148° C.



1HNMR(CDCl3)δ 1.56(s, 3H), 1.80(s, 3H), 3.21(s, 3H),



3.41(s, 3H), 3.65(s, 3H), 3.77(s, 3H), 4.61(d, J=6.9Hz, 2H),



5.54(t, J=6.9Hz, 1H), 6.94(s, 1H), 6.98(t, J=8.4Hz, 1H),



7.05(ddd, J=8.4, 2.4, 0.9Hz, 1H), 7.14(dd, J=12.0, 2.4Hz, 1H),



7.38(d, J=8.7Hz, 2H), 7.71(d, J=8.7Hz, 2H)



IR(KBr)1736, 1519, 1471, 1357, 1257, 1150, 1061, 984, 872cm−1


I-332
m.p.170–171° C.



1HNMR(DMSO-d6)δ 1.73(s, 3H), 1.77(s, 3H), 3.31(s, 3H),



3.73(s, 3H), 4.62(d, J=7.0Hz, 2H), 5.48(t, J=7.0Hz, 1H),



6.87(d, J=8.9Hz, 2H), 7.00(s, 1H),



7.03(ddd, J=8.7, 2.3, 0.9Hz, 1H), 7.10(dd, J=12.3, 2.3Hz, 1H),



7.18(t, J=8.7Hz, 1H), 7.48(d, J=8.9Hz, 2H), 9.60(s, 1H),



12.9(brs, 1H)



IR(KBr)3258, 1687, 1615, 1523, 1465, 1373, 1260, 1233, 1057,



994, 835, 823cm−1


I-333
m.p.172–174° C.



1HNMR(CDCl3)δ 3.21(s, 3H), 3.41(s, 3H), 3.61(s, 3H),



3.77(s, 3H), 5.17(s, 2H), 6.94(s, 1H), 7.01–7.04(m, 2H),



7.13–7.18(m, 1H), 7.33–7.49(m, 7H), 7.70(d, J=9.0Hz, 2H)



IR(KBr)1725, 1522, 1463, 1346, 1261, 1230, 1147, 1058, 878,



756cm−1


I-334
m.p.149–151° C.



1HNMR(CDCl3)δ 2.36(s, 3H), 3.21(s, 3H), 3.41(s, 3H),



3.61(s, 3H), 3.77(s, 3H), 5.13(s, 2H), 6.93(s, 1H),



7.00–7.03(m, 2H), 7.12–7.17(m, 1H), 7.20(d, J=8.4Hz, 2H),



7.35(d, J=8.4Hz, 2H), 7.38(d, J=8.7Hz, 2H),



7.70(d, J=8.7Hz, 2H)



IR(KBr)1731, 1519, 1472, 1370, 1298, 1152, 1058, 874, 791cm−1

















TABLE 70







I-335
m.p.173–174° C.



1HNMR(DMSO-d6)δ 1.64(s, 3H), 1.70(s, 3H),



2.45(q, J=6.9Hz, 2H), 3.31(s, 2H), 3.73(s, 3H),



4.04(t, J=6.9Hz, 2H), 5.22(t, J=6.9Hz, 1H),



6.87(d, J=8.7Hz, 2H), 6.99(s, 1H),



7.03(ddd, J=8.7, 2.1, 0.9Hz, 1H), 7.10(dd, J=12.3, 2.1Hz, 1H),



7.16(t, J=8.7Hz, 1H), 7.48(d, J=8.7Hz, 2H), 9.61(s, 1H),



12.9(brs, 1H)



IR(KBr)3303, 1696, 1523, 1473, 1371, 1261, 1241, 1061, 1009,



839cm−1


I-336
m.p.222–224° C.



1HNMR(DMSO-d6)δ 3.31(s, 3H), 3.73(s, 3H), 5.20(s, 2H),



6.87(d, J=8.7Hz, 2H), 7.00(s, 1H), 7.03–7.07(m, 1H),



7.13(dd, J=12.3, 2.1Hz, 1H), 7.26(t, J=8.7Hz, 1H),



7.36–7.52(m, 7H), 9.61(s, 1H), 12.9(brs, 1H)



IR(KBr)3268, 1689, 1523, 1465, 1374, 1261, 1055, 836cm−1


I-337
m.p.205–206° C.



1HNMR(DMSO-d6)δ 2.32(s, 3H), 3.31(s, 3H), 3.72(s, 3H),



5.15(s, 2H), 6.87(d, J=8.7Hz, 2H), 6.99(s, 1H),



7.04(ddd, J=9.0, 1.9, 0.9Hz, 1H), 7.12(dd, J=12.3, 1.9Hz, 1H),



7.23(d, J=8.0Hz, 2H), 7.24(t, J=9.0Hz, 1H),



7.38(d, J=8.0Hz, 2H), 7.48(d, J=8.7Hz, 2H), 9.60(s, 1H),



12.9(brs, 1H)



IR(KBr)3303, 1696, 1523, 1464, 1261, 1241, 1056, 993, 838,



811, 791cm−1


I-338
m.p.120–121° C.



1HNMR(CDCl3)δ 3.13(s, 3H), 3.50(s, 3H), 3.78(s, 3H),



5.08(s, 1H), 5.20(s, 2H), 6.90(m, 2H), 7.09(s, 1H),



7.15–7.19(m, 3H), 7.37–7.50(m, 5H),



7.56(dd, J=10.8, 2.1Hz, 1H), 7.64(d, J=2.4Hz, 1H), 9.90(s, 1H)



IR(KBr)3460, 2934, 1694, 1609, 1585, 1518, 1467, 1442, 1348,



1295, 1273, 1255, 1238, 1171, 1123, 1075, 1003, 960, 828, 807,



755, 700, 653, 582, 522cm−1


I-339
m.p.256–258° C.



1HNMR(DMSO-d6)δ 3.34(s, 3H), 3.35(s, 3H), 3.72(s, 3H),



5.28(s, 2H), 6.75(d, J=8.1Hz, 2H), 7.05–7.11(m, 3H),



7.36–7.45(m, 4H), 7.53(d, J=8.1Hz, 2H), 7.60–7.66(m, 2H),



9.44(s, 1H), 12.84(s, 1H)



IR(KBr)3459, 2940, 2563, 1706, 1612, 1522, 1469, 1349, 1294,



1258, 1185, 1114, 1082, 1063, 1000, 961, 919, 827, 756, 699,



524cm−1

















TABLE 71







I-340
m.p.165–166° C.



1HNMR(CDCl3)δ 3.14(s, 3H), 3.19(s, 3H), 3.51(s, 3H),



3.76(s, 2H), 5.21(s, 2H), 7.11(s, 1H), 7.17(d, J=8.4Hz, 1H),



7.29–7.50(m, 9H), 7.57(dd, J=8.1, 2.1Hz, 1H),



7.65(d, J=2.1Hz, 1H), 10.02(s, 1H)



IR(CHCl3)2938, 2844, 1698, 1613, 1590, 1515, 1469, 1372,



1331, 1293, 1255, 1174, 1150, 1122, 1092, 1005, 969, 873,



816cm−1


I-341
m.p.195–197° C.



1HNMR(CDCl3)δ 3.13(s, 3H), 3.18(s, 3H), 3.47(s, 3H),



3.77(s, 3H), 5.20(s, 2H), 6.97(s, 1H), 7.17(d, J=8.7Hz, 1H),



7.30–7.50(m, 9H), 7.58(dd, J=8.7, 1.8Hz, 1H),



7.67(d, J=1.8Hz, 1H)



IR(CHCl3)2938, 1740, 1707, 1601, 1516, 1472, 1371, 1293,



1260, 1174, 1149, 1117, 1082, 1060, 1002, 971, 875cm−1


I-342
m.p.207–209° C.



1HNMR(CD3OD)δ 3.40(s, 3H), 3.72(s, 3H), 5.21(s, 3H),



6.76–6.78(m, 2H), 6.97(s, 1H), 7.01–7.17(m, 4H),



7.31–7.52(m, 6H)



IR(KBr)3366, 1705, 1612, 1591, 1522, 1473, 1434, 1375, 1253,



1234, 1130, 1084, 1061, 998, 918, 864, 835, 813, 792, 743, 697,



648, 526cm−1


I-343
m.p.206–208° C.



1HNMR(CDCl3)δ 3.14(s, 3H), 3.48(s, 3H), 3.72(s, 3H),



5.20(s, 2H), 5.48(br, 1H), 6.85–6.89(m, 3H), 7.15–7.19(m, 3H),



7.37–7.51(m, 8H), 7.56(dd, J=8.4, 2.4Hz, 1H),



7.68(d, J=2.4Hz, 1H)



IR(CHCl3)3320, 2938, 1612, 1520, 1474, 1371, 1292, 1257,



1172, 1120, 1090, 1005, 972, 857, 837, 818cm−1


I-344
m.p.187–190° C.



1HNMR(CDCl3)δ 2.33(s, 3H), 3.13(s, 3H), 3.50(s, 3H),



3.76(s, 3H), 5.20(s, 2H), 7.10(s, 1H), 7.15–7.19(m, 3H),



7.28–7.50(m, 7H), 7.56(dd, J=8.7, 2.4Hz, 1H),



7.64(d, J=2.4Hz, 1H), 9.93(s, 1H)



IR(CHCl3)2930, 2836, 1750, 1695, 1588, 1513, 1465, 1369,



1329, 1220, 1166, 1122, 1091, 1003, 962, 912, 848, 813cm−1

















TABLE 72







I-345
m.p.218–220° C.



1HNMR(DMSO-d6)δ 2.29(s, 3H), 3.36(s, 3H), 3.37(s, 3H),



3.76(s, 3H), 5.29(s, 2H), 7.11–7.16(m, 3H), 7.31–7.46(m, 6H),



7.52–7.55(m, 2H), 7.62–7.68(m, 2H), 13.00(br, 1H)



IR(KBr)3433, 2940, 2600, 1757, 1713, 1652, 1611, 1518, 1471,



1365, 1295, 1260, 1216, 1200, 1171, 1117, 1082, 1061, 1022,



998, 975, 916, 897, 829, 804, 735, 697, 525cm−1


I-346
m.p.206–208° C.



1HNMR(CDCl3)δ 2.31(s, 3H), 3.13(s, 3H), 3.45(s, 3H),



3.58(s, 3H), 3.76(s, 3H), 5.19(s, 2H), 6.95(s, 1H),



7.08–7.16(m, 3H), 7.34–7.50(m, 7H), 7.57(dd, J=8.7, 2.4Hz, 1H),



7.67(d, J=2.4Hz, 1H)



IR(CHCl3)2939, 1732, 1613, 1599, 1518, 1468, 1371, 1290,



1169, 1117, 1081, 1064, 1004, 972, 961, 905, 847, 828cm−1


I-347
m.p.201–203° C.



1HNMR(DMSO-d6)δ 1.72(s, 3H), 1.76(s, 3H), 3.34(s, 3H),



3.63(s, 3H), 4.51(d, J=4.2Hz, 2H),



5.49(t, J=4.6Hz, 1H), 6.66(s, 1H), 6.76(s, 2H),



6.86(s, 1H), 7.23–7.29(m, 2H), 7.62–7.66(m, 2H)



IR(KBr)3431, 2935, 1575, 1516, 1462, 1444, 1421, 1397, 1375,



1224, 1159, 1063, 837cm−1


I-348
m.p.265–266° C.



1HNMR(DMSO-d6)δ 2.31(s, 3H), 3.33(s, 3H), 3.62(s, 3H),



5.03(s, 2H), 6.66(s, 1H), 6.72–6.90(m, 4H), 7.18–7.28(m, 3H),



7.38(d, J=5.2Hz, 2H), 7.64(dd, J=4.0, 5.4Hz, 2H)



IR(KBr)3428, 2925, 1575, 1516, 1463, 1442, 1396, 1374, 1248,



1221, 1129, 1087, 1068cm−1


I-349
m.p.262–263° C.



1HNMR(DMSO-d6)δ 1.64(s, 3H), 1.70(s, 3H),



2.43(dt, J=4.6, 5.0Hz, 2H), 3.34(s, 3H), 3.62(s, 3H),



3.91(t, J=4.8Hz, 2H), 5.25(t, J=4.6Hz, 1H), 6.70(s, 1H),



6.75(s, 2H), 6.87(s, 1H), 7.23–7.29(m, 2H),



7.64(dd, J=2.0, 5.8Hz, 2H)



IR(KBr)3430, 2934, 1575, 1516, 1464, 1443, 1422, 1398, 1375,



14246, 1225, 1065, 1015cm−1

















TABLE 73







I-350
1HNMR(CDCl3)δ 1.76(s, 3H), 1.81(d, J=0.6Hz, 3H), 2.54(s,



3H), 2.73(s, 3H), 3.23(s, 3H), 3.54(s, 3H), 3.77(s, 3H), 4.63(d,



J=6.6Hz, 2H), 5.49(m, 1H), 6.85(s, 1H), 7.09(d, J=8.4Hz, 1H),



7.30–7.40(m, 4H), 7.53–7.59(m, 2H)



IR(CHCl3)2936, 1606,



1515, 1475, 1366, 1116, 1078, 970, 875, 820 cm−1


I-351
1HNMR(CDCl3)δ 1.68(s, 3H), 1.74(d, J=0.9Hz, 3H),



2.48–2.60(m, 5H), 2.75(s, 3H), 3.21(s, 3H), 3.54(s, 3H), 3.77



(s, 3H), 4.07(t, J=6.9Hz, 2H), 5.21(m, 1H), 6.85(s, 1H), 7.07(d,



J=8.7Hz, 1H), 7.30–7.42(m, 4H), 7.53–7.59(m, 2H)



IR(CHCl3)



2928, 1607, 1517, 1476, 1367, 1267, 1118, 1080, 1014, 971,



892, 822 cm−1


I-352
m.p. 201–203° C.



1HNMR(CDCl3)δ 3.35(s, 3H), 3.75(s, 3H), 3.76(s, 3H),



5.26(s, 2H), 6.79–6.83(m, 2H), 6.97(s, 1H), 7.01(s, 1H),



7.31–7.54(m, 10H), 9.45(s, 1H)



IR(KBr)3600–2800(br), 1610,



1525, 1492, 1462, 1377, 1337, 1298, 1208, 1171, 1114,



1054, 1031 cm−1


I-353
m.p. 141–143° C.



1HNMR(CDCl3)δ 3.56(s, 3H), 3.78(s, 3H), 3.80(s, 3H),



4.86(s, 1H), 5.26(s, 2H), 6.88–6.92(m, 2H), 6.92(s, 1H),



6.93(s, 1H), 7.24–7.29(m, 2H), 7.36–7.41(m, 1H),



7.45–7.50(m, 2H)



IR(KBr)3600–2800(br), 1612, 1524, 1491,



1463, 1448, 1378, 1263, 1205, 1177, 1153, 1071,



1053, 1026 cm−1


I-354
m.p. 115–115.5° C.



1HNMR(CDCl3)δ 3.19(s, 3H), 3.56(s, 3H), 3.79(s, 3H),



3.80(s, 3H), 5.27(s, 2H), 6.93(s, 1H), 6.94(s, 1H), 7.25–7.27



(m, 2H), 7.32–7.40(m, 3H), 7.60–7.64(m, 2H)



IR(KBr)3600–2800(br), 1524, 1492, 1463, 1379, 1266, 1210,



1174, 1154, 1126, 1082, 1053, 1029 cm−1


I-355
m.p. 139–140° C.



1HNMR(CDCl3)δ 1.77(d, J=0.6Hz, 3H), 1.81(d, J=0.9Hz,



3H), 3.82(s, 6H), 4.64(d, J=6.9Hz, 2H), 5.52–5.57(m, 1H), 6.95



(s, 1H), 6.97(s, 1H), 7.04(t, J=8.4Hz, 1H), 7.26–7.31(m, 1H),



7.37(dd, J=2.1, 12.6Hz, 1H), 7.73–7.77(m, 2H), 8.26–8.31(m,



2H)



IR(KBr)3600–2800(br), 1593, 1524, 1508, 1486, 1464,



1380, 1355, 1278, 1264, 1211, 1054, 1029 cm−1

















TABLE 74







I-356
foam



1HNMR(CDCl3)δ 2.68(s, 3H), 3.13(s, 3H), 3.53(s, 3H),



3.78(s, 3H), 5.19(s, 2H), 6.83(s, 1H), 7.10–7.19(m, 3H),



7.30–7.50(m, 7H), 7.56–7.64(m, 2H)



IR(KBr)1607, 1520, 1482, 1365, 1232, 1177, 1119,



1082, 1013 cm−1


I-357
1HNMR(CDCl3)δ 2.39(s, 3H), 3.48(s, 3H), 3.75(s, 3H),



5.11(s, 2H), 5.67(s, 1H), 5.88(s, 1H), 6.46(s, 1H), 6.95(d.d,



J=8.7&1.8Hz, 1H), 7.02–7.11(m, 1H), 7.03(d, J=8.7Hz, 1H),



7.07(d, J=1.8Hz, 1H), 7.22(d, J=8.7Hz, 2H), 7.34(d, J=



8.7Hz, 2H), 7.36–7.47(m, 3H)



IR(KBr)3546, 3511, 1611, 1586,



1517, 1478, 1405, 1360, 1318, 1240, 1109, 1068, 1007 cm−1


I-358
1HNMR(CDCl3)δ 3.03(s, 6H), 3.48(s, 3H), 3.77(s, 3H),



5.15(s, 2H), 5.71(s, 1H), 6.73(dd, J=8.7&1.8Hz, 1H), 6.82(d, J=



8.4Hz, 2H), 6.97(d, J=1.8Hz, 1H), 6.98(dJ=8.7Hz, 1H), 7.11(s,



1H), 7.33–7.48(m, 5H), 7.56(d, J=8.7Hz, 2H), 9.92(s, 1H)



IR(KBr)3524, 3447, 1697, 1612, 1586, 1525, 1468, 1364,



1283, 1257, 1230, 1201, 1127, 1103, 1073, 1020 cm−1


I-359
1HNMR(CDCl3)δ 3.04(s, 6H), 3.14(s, 3H), 3.48(s, 3H),



3.76(s, 3H), 5.17(s, 2H), 6.84(d, J=8.7Hz, 2H), 7.06–7.17(m,



3H), 7.34(d, J=1.8Hz, 1H), 7.35–7.50(m, 6H), 7.55(d,



J=8.7Hz, 2H), 10.08(s, 1H)



IR(KBr)1698, 1610, 1527, 1470, 1357, 1290, 1232, 1183, 1115,



1083, 1018 cm−1


I-360
1HNMR(CDCl3)δ 2.56(s, 3H), 3.02(s, 6H), 3.54(s,



3H), 3.76(s, 3H), 5.16(s, 2H), 5.67(s, 1H), 6.80(d, J=8.4Hz,



2H), 6.85(s, 1H), 6.91(d.d, J=8.4&2.1Hz, 1H), 7.01(d, J=



8.4Hz, 1H), 7.05(d, J=2.1Hz, 1H), 7.30–7.47(m, 5H), 7.55(d,



J=8.7Hz, 2H)



IR(KBr)3542, 3436, 1605, 1530, 1483, 



1391, 1360, 1287, 1253, 1234, 1169, 1074, 1016 cm−1


I-361
1HNMR(CDCl3)δ 1.31(d, J=6.9Hz, 6H), 2.57(s,



3H), 2.97(quint, J=6.9Hz, 1H), 3.54(s, 3H), 3.76(s, 3H), 5.17(s,



2H), 5.68(s, 1H), 6.86(s, 1H), 6.92(dd, J=8.4&2.1Hz, 1H), 7.02



(d, J=8.4Hz, 1H), 7.05(d, J=2.1Hz, 1H), 7.31(d, J=8.1Hz,



2H), 7.34–7.46(m, 5H), 7.55(d, J=8.1Hz, 2H)



IR(KBr)3446, 1606, 1585, 1522, 1484, 1457, 1394, 1356, 1289,



1257, 1228, 1172, 1076, 1018, 1007 cm−1

















TABLE 75







I-362
1HNMR(CDCl3)δ 1.31(d, J=6.9Hz, 6H), 2.98(quint, J=6.9Hz,



1H), 3.46(s, 3H), 3.74(s, 3H), 5.15(s, 2H), 5.67(s, 1H), 5.92(s,



1H), 6.48(s, 1H), 6.97(dd, J=8.4&1.8Hz, 1H), 7.03(d, J=8.4Hz,



1H), 7.10(d, J=1.8Hz, 1H), 7.25(s, 1H), 7.31(d, J=7.8Hz, 2H),



7.34–7.49(m, 5H), 7.57(d, J=7.8Hz, 2H)



IR(KBr)3538, 3505, 3465, 1610, 1586, 1552, 1518, 1584,



1458, 1398, 1281, 1288, 1245, 1198, 1112, 1071, 1002 cm−1


I-363
1HNMR(CDCl3)δ 2.66(s, 3H), 3.06(s, 3H), 3.13(s, 3H),



3.57(s, 3H), 3.67(s, 3H), 3.78(s, 3H), 5.19(s,



2H), 6.44(s, 1H), 6.85(s, 1H), 7.15(d, J=8.7Hz, 1H),



7.28–7.51(m, 10H)



IR(KBr)3443, 1604, 1518, 1479, 1364, 1237, 1177, 1153, 1118,



1078, 1014 cm−1


I-364
1HNMR(CDCl3)δ 1.77(s, 3H), 1.81(s, 3H), 2.70(s,



3H), 3.06(s, 3H), 3.24(s, 3H), 3.58(s, 3H), 3.78(s, 3H), 4.64(d,



J=6.6Hz, 2H), 5.49(t, J=6.6Hz, 1H), 6.42(s, 1H), 6.85(s, 1H),



7.09(d, J=8.4Hz, 1H), 7.28–7.49(m, 5H)



IR(KBr)3432, 3285, 1604, 1518, 1479, 1364, 1328, 1291, 1269,



1237, 1177, 1154, 1117, 1078 cm−1


I-365
1HNMR(CDCl3)δ 1.57(s, 3H), 1.67(s, 3H), 1.77(s,



3H), 1.81(s, 3H), 2.70(s, 3H), 2.96(s, 3H), 3.24(s, 3H), 3.53(s,



3H), 3.78(s, 3H), 4.32(d, J=7.2Hz, 2H), 4.64(d, J=6.9Hz, 2H),



5.25(t, J=6.9Hz, 1H), 5.49(t, J=7.2Hz, 1H), 6.85(s, 1H),



7.09(d, J=8.7Hz, 1H), 7.31–7.14(m, 3H),



7.44–7.64(m, 3H)



IR(KBr)3433, 1600, 1517, 1474, 1365, 1339, 1237,



1178, 1153, 1118, 1078, 1014 cm−1


I-366
1HNMR(CDCl3)δ 1.76(s, 3H), 1.82(s, 3H), 3.08(s,



3H), 348(s, 3H), 3.75(s, 3H), 4.62(d, J=7.2Hz, 2H), 5.54(t,



J=7.2Hz, 1H), 5.70(s, 1H), 5.85(s, 1H), 6.40(s, 1H), 6.46(s,



1H), 6.89–7.00(m, 2H), 7.05(d, J=1.5Hz, 1H), 7.43–7.51(m,



3H)



IR(KBr)3437, 1605, 1585, 1518, 1482, 1386,



1323, 1243, 1152, 1114, 1071, 1002 cm−1


I-367
1HNMR(CDCl3)δ 2.37(s, 3H), 3.21(s, 3H), 3.47(s,



3H), 3.64(s, 3H), 3.77(s, 3H), 3.84(s, 3H), 5.17(s, 2H), 6.63(s,



1H), 6.78(s, 1H), 7.10(s, 1H), 7.20(d, J=8.1Hz, 2H), 7.40(d,



J=8.1Hz, 2H), 7.41(d, J=9.3Hz, 2H), 7.70(d, J=9.3Hz, 2H)



IR(KBr)1702, 1607, 1589, 1518, 1468, 1356, 1216, 1151, 1067,



1039, 1018 cm−1

















TABLE 76







I-368
1HNMR(CDCl3)δ 2.37(s, 3H), 3.21(s,



3H), 3.48(s, 6H), 3.65(s, 3H), 3.73(s, 3H), 3.83(s, 3H), 4.32(d,



J=11.4Hz, 1H), 4.51(d, J=11.4Hz, 1H), 5.17(s, 2H), 6.93(s, 1H),



6.71(s, 1H), 6.88(s, 1H), 7.21(d, J=8.4Hz, 2H), 7.32–7.41(m,



4H), 7.73(d, J=8.4Hz, 2H)



IR(KBr)3514, 1608, 1516, 1465, 1355, 1215, 1149, 1076,



1039, 1017 cm−1


I-369
m.p. 125–127° C.



1HNMR(CDCl3)δ 2.60(s, 3H), 3.52(s, 3H), 3.73(s, 3H),



3.84(s, 3H), 5.20(s, 2H), 6.83(s, 1H), 7.00–7.48(m, 12H)



IR(KBr)3434, 2943, 1611, 1580, 1520, 1498, 1480, 1398, 1297,



1268, 1245, 1179, 1129, 1079, 1009 cm−1


I-370
m.p. 137–139° C.



1HNMR(CDCl3)δ 3.43(s, 3H), 3.71(s, 3H), 3.85(s,



3H), 5.19(s, 2H), 5.92(s, 1H), 6.43(s, 1H), 7.01–7.51(m, 12H)



IR(KBr)3391, 2937, 1615, 1583, 1520, 1503, 1482, 1464,



1405, 1359, 1314, 1292, 1273, 1239, 1121, 1108, 1069,



1005 cm−1


I-371
m.p. 92–94° C.



1HNMR(CDCl3)δ 1.76(s, 3H), 1.81(s, 3H), 2.70(s,



3H), 3.53(s, 3H), 3.73(s, 3H), 3.84(s, 3H), 4.63(d, J=6.9Hz,



2H), 5.53(m, 1H), 6.84(s, 1H), 7.00–7.45(m, 7H)



IR(KBr)3433, 2938, 1609, 1581, 1523, 1499, 1480, 1401, 1368,



1297, 1268, 1240, 1178, 1118, 1079, 1021 cm−1


I-372
foam



1HNMR(CDCl3)δ 1.68(s, 3H), 1.74(d, J=0.6Hz,



3H), 2.50–2.59(m, 2H), 2.71(s, 3H), 3.53(s, 3H), 3.73(s, 3H),



3.84(s, 3H), 4.04(t, J=7.2Hz, 2H), 5.23(m, 1H), 6.83(s, 1H),



7.00–7.42(m, 7H)



IR(CHCl3)3011, 2938, 1612, 1581, 1522, 1500, 1480, 1465,



1398, 1370, 1301, 1268, 1238, 1209, 1176, 1119,



1081, 1017 cm−1


I-373
m.p. 95–98° C.



1HNMR(CDCl3)δ 1.76(s, 3H), 1.80(s, 3H), 3.43(s,



3H), 3.72(s, 3H), 3.85(s, 3H), 4.63(d, J=6.6Hz, 2H), 5.56(m,



1H), 5.92(s, 1H), 6.43(s, 1H), 7.01–7.42(m, 7H)



IR(KBr)3318, 2937, 1612, 1598, 1500, 1485, 1464, 1450, 1361,



1298, 1275, 1240, 1104, 1072, 1011 cm−1

















TABLE 77







I-374
m.p. 69–71° C.



1HNMR(CDCl3)δ 1.68(s, 3H), 1.74(d, J=0.6Hz,



3H), 2.50–2.60(m, 2H), 3.43(s, 3H), 3.71(s, 3H), 3.85(s, 3H),



4.04(t, J=7.2Hz, 2H), 5.23(m, 1H), 5.91(s, 1H), 6.43(s, 1H),



7.00–7.42(m, 7H)



IR(KBr)3385, 2933, 1611, 1583, 1521, 1503, 1485, 1466, 1403,



1358, 1299, 1276, 1241, 1122, 1104, 1071, 1011 cm−1


I-375
m.p. 105–107° C.



1HNMR(CDCl3)δ 2.36(s, 3H), 2.59(s, 3H), 3.52(s, 3H),



3.73(s, 3H), 3.84(s, 3H), 5.16(s, 2H), 6.83(s, 1H), 7.00–



7.42(m, 11H)



IR(KBr)3433, 2940, 1609, 1581, 1522, 1499, 1481, 1461,



1401, 1366, 1296, 1269, 1240, 1178, 1117, 1079,



1021, 1011 cm−1


I-376
m.p. 142–144° C.



1HNMR(CDCl3)δ 2.37(s, 3H), 3.42(s, 3H), 3.71(s, 3H),



3.85(s, 3H), 5.14(s, 2H), 5.91(s, 1H), 6.43(s, 1H), 7.01–7.42(m,



11H)



IR(KBr)3367, 2936, 1615, 1583, 1520, 1502, 1482,



1464, 1447, 1405, 1359, 1317, 1291, 1274, 1239,



1121, 1109, 1070, 1009 cm−1


I-377
m.p. 174–176° C.



1HNMR(CDCl3)δ 3.21(s, 3H), 3.41(s, 3H), 3.63(s, 3H),



3.77(s, 3H), 5.30(s, 2H), 6.94(s, 1H), 7.03–7.05(m, 2H),



7.15–7.20(m, 1H), 7.25(m, 1H), 7.38(d, J=8.9Hz, 2H), 7.62(d,



J=7.8Hz, 1H), 7.71(d, J=8.9Hz, 2H), 7.76(dt, J=7.8, 1.5Hz, 1H),



8.60(m, 1H)



IR(KBr)1732, 1523, 1474, 1368, 1148, 1061,



863, 845, 790 cm−1


I-378
m.p. > 260° C.



1HNMR(DMSO-d6)δ 3.32(s, 3H), 3.73(s, 3H), 5.28(s, 2H),



6.87(d, J=8.7Hz, 2H), 7.00(s, 1H), 7.04(dd, J=8.9, 1.8Hz, 1H)



7.16(dd, J=12.3, 1.8Hz, 1H), 7.26(t, J=8.9Hz, 1H), 7.39(m, 1H),



7.57(d, J=8.7Hz, 2H), 7.58(d, J=7.8Hz, 1H), 7.89(dt, J=



7.8, 1.5Hz, 1H), 8.61(m, 1H), 9.61(s, 1H), 12.9(brs, 1H)



IR(KBr)3383, 1735, 1705, 1610, 1522, 1471, 1272,



1226, 1059, 1014, 838, 762 cm−1


I-379
m.p. 137–138° C.



1HNMR(CDCl3)δ 1.77(s, 3H), 1.82(s, 3H), 3.46(s, 3H), 3.79



(s, 3H), 4.64(d, J=4.6Hz, 1H), 5.56(t, J=4.6Hz, 1H), 6.92–



7.20(m, 6H), 7.61(dd, J=3.6, 5.8Hz, 2H), 9.96(Brs, 1H)



IR(KBr)3434, 2966, 2935, 2839, 1702, 1695, 1521,



1466, 1378, 1299, 1287, 1272, 1240, 1012, 840 cm−1

















TABLE 78







I-380
m. p. 98–99° C.



1HNMR(CDCl3)δ 2.37(s, 3H), 3.45(s, 3H), 3.78(s, 3H), 5.15(s,



2H), 6.93–7.26(m, 4H), 7.36(d, J=7.8Hz, 2H), 7.62(dd, J=4.0,



8.8Hz, 2H), 9.94(s, 1H)



IR(KBr)3446, 2933, 2845, 1699, 1521, 1473, 1463,



1381, 1293, 1261, 1238, 1221, 1131, 803 cm−1


I-381
m.p. 118–119° C.



1HNMR(CDCl3)δ 1.69(s, 3H), 1.74(s, 3H), 2.54(dt, J=5.0,



7.8Hz, 2H), 3.45(s, 3H), 3.78(s, 3H), 4.05(t, J=7.2Hz, 2H),



5.24(t, J=4.4Hz, 1H), 6.95–7.16(m, 6H), 7.61(dd,



J=3.4, 8.8Hz, 2H), 9.95(brs, 1H)



IR(KBr)3433, 2959, 2930, 2842, 1701, 1602, 1522,



1464, 1379, 1303, 1263, 1222, 1132, 1018 cm−1


I-382
m.p. 93–94° C.



1HNMR(DMSO-d6)δ 1.74(s, 3H), 1.78(s, 3H), 3.32(s,



3H), 3.71(s, 3H), 4.62(d, J=7.0Hz, 2H), 5.48(t, J=5.8Hz, 1H),



6.91(s, 1H), 7.09–7.35(m, 2H), 7.64–7.71(m, 2H)



IR(KBr)3433, 2976, 2937, 1707, 1604, 1520, 1472,



1376, 1300, 1265, 1226, 1160, 1131, 1060, 839 cm−1


I-383
m.p. 98–99° C.



1HNMR(DMSO-d6)δ 2.32(s, 3H), 3.31(s, 3H), 3.70(s, 3H),



5.13(s, 2H), 6.88(s, 1H), 7.14–7.39(m, 5H), 7.63–7.70(m, 2H)



IR(KBr)3433, 2981, 2937, 1704, 1603, 1520, 1470,



1375, 1301, 1266, 1226, 1159, 1061, 839 cm−1


I-384
oil



1HNMR(DMSO-d6)δ 1.68(s, 3H), 1.74(s, 3H), 2.48–2.56(m,



2H), 3.57(s, 3H), 3.77(s, 3H), 3.98(t, J=4.8Hz, 2H), 5.26(t,



J=4.2Hz, 1H), 6.84(s, 1H), 7.05–7.36(m, 5H), 7.63–7.70(m, 2H)



IR(KBr)3433, 2979, 2938, 1726, 1603, 1522, 1470, 1376,



1301, 1264, 1226, 1160, 1132, 1080, 1058, 840 cm−1


I-385
m.p. 137–138° C.



1HNMR(CDCl3)δ 1.77(s, 3H), 1.82(s, 3H), 2.55(s, 3H),



3.21(s, 3H), 3.57(s, 3H), 3.78(s, 3H), 4.56(d, J=7.0Hz, 2H),



5.52(t, J=7.4Hz, 1H), 6.84(s, 1H), 7.02(d, J=8.8Hz, 2H),



7.34–7.40(m, 4H), 7.70(d, J=8.8Hz, 2H)



IR(KBr)3434, 2938, 1607, 1519, 1366, 1244, 1174, 1151, 1072,



871, 796 cm−1

















TABLE 79







I-386
m.p. 169–170° C.



1HNMR(CDCl3)δ 2.48(s, 3H), 3.21(s, 3H), 3.56(s, 3H),



3.77(s, 3H), 5.08(s, 2H), 6.84(s, 1H), 7.07(d, J=5.8Hz, 2H),



7.19–7.39(m, 4H), 7.70(d, J=6.0Hz, 2H)



IR(KBr)3432, 3016, 2935, 1605, 1519, 1479, 1368,



1357, 1233, 1176, 1151, 1076, 876, 843, 798 cm−1


I-387
m.p. 140–141° C.



1HNMR(CDCl3)δ 1.68(s, 3H), 1.75(s, 3H), 2.51(dt,



J=4.4, 4.6Hz, 2H), 2.55(s, 3H), 3.21(s, 3H), 3.56(s, 3H),



3.77(s, 3H), 3.97(t, J=4.8Hz, 2H),



5.26(t, J=4.0Hz, 1H), 6.84(s, 1H), 6.99(d,



J=5.8Hz, 2H), 7.34–7.39(m, 4H), 7.70(d, J=5.8Hz, 2H)



IR(KBr)3445, 2937, 1608, 1519, 1480, 1391, 1361, 1351,



1237, 1177, 1154, 1077, 962, 871, 862, 800 cm−1


I-388
m.p. 124–125° C.



1HNMR(DMSO-d6)δ 1.73(s, 3H), 1.75(s, 3H), 3.30(s,



3H), 3.65(s, 3H), 4.54(d, J=6.6Hz, 2H), 5.47(t, J=6.4Hz, 1H),



6.40(s, 1H), 6.82–6.94(m, 4H), 7.20(d, J=



8.6Hz, 2H), 7.44(d, J=8.2Hz, 2H)



IR(KBr)3411, 2934, 1608, 1523, 1487, 1396, 1231, 1175, 1105,



1072, 996, 898 cm−1


I-389
m.p. 93–94° C.



1HNMR(DMSO-d6)δ 2.32(s, 3H), 3.32(s, 3H), 3.64(s,



3H), 5.08(s, 2H), 6.40(s, 1H), 6.84(d, J=8.6Hz, 2H), 6.98(d,



J=8.6Hz, 2H), 7.19–7.23(m, 4H), 7.34–7.46(m, 4H)



IR(KBr)3398, 2933, 1609, 1523, 1486, 1461, 1398, 1235, 1174,



1119, 1071, 997, 829 cm−1


I-390
oil



1HNMR(DMSO-d6)δ 1.72(s, 3H), 1.74(s, 3H), 2.52(dt,



J=4.8, 5.0Hz, 2H), 3.24(s, 3H), 3.58(s, 3H), 4.06(t, J=7.2Hz,



2H), 5.24(t, J=4.4Hz, 1H), 6.80–6.95(m, 4H), 7.22(d, J=8.4Hz,



2H), 7.46(d, J=8.2Hz, 2H)



IR(KBr)3340, 2934, 1608, 1522, 1486, 1396, 1285, 1230, 1175,



1106, 1072, 996, 828 cm−1


I-391
1HNMR(CDCl3+CD3OD)δ 3.05(s,



3H), 3.48(s, 3H), 3.75(s, 3H), 5.16(s, 2H), 5.97(s, 1H),



6.02(s, 1H), 6.47(s, 1H), 6.94(d.d, J=



8.4&1.8Hz, 1H), 7.04(d, J=8.4Hz, 1H), 7.07



(d, J=1.8Hz, 1H), 7.22–7.52(m, 9H)



IR(KBr)3548, 3357, 1603, 1589, 1520, 1487, 1460, 1445, 1410,



1329, 1286, 1247, 1153, 1115, 1077, 1010 cm−1

















TABLE 80







I-392
1HNMR(CDCl3)δ 2.37(s, 3H), 2.77–2.88(broad,



1H), 3.47(s, 3H), 3.64(s, 3H), 3.72(s, 3H), 3.82(s, 3H), 4.32



(d.d, J=11.1&0.6Hz, 1H), 4.45–4.56(broad, 1H), 4.92(s, 1H),



5.16(s, 2H), 6.70(d, J=9.3Hz, 2H), 6.88(s, 1H), 6.92(d,



J=9.0Hz, 2H), 7.22(d, J=8.4Hz, 2H), 7.38(d,



J=8.4Hz, 2H), 7.56(d, J=9.0Hz, 2H)



IR(KBr)3476, 1610, 1519, 1476, 1463, 1386, 1265, 1215,



1074, 1041, 1010 cm−1


I-393
foam



1HNMR(CD3OD)δ 2.34(s, 3H), 3.38(s, 3H), 3.68(s,



3H), 4.00(dd, J=9.9, 8.7Hz, 1H), 4.17(dd, J=9.9, 3.0Hz,



1H), 5.06(dd, J=8.7, 3.0Hz, 1H), 6.43(s, 1H), 6.78(dd, J=8.7,



1.8, 1H), 6.85(d, J=8.7Hz, 2H), 6.88(d, J=1.8Hz, 1H), 6.91(d,



J=8.4Hz, 1H), 7.20(d, J=8.1Hz, 2H), 7.36(d, J=8.1Hz, 2H),



7.46(d, J=8.7Hz, 2H)



IR(Nujol)3367, 1655, 1612, 1586, 1523, 1489, 1459, 1254,



1225, 1115, 1072, 1015, 941, 817 cm−1


I-394
foam



1HNMR(CD3OD)δ 3.38(s, 3H), 3.67(s, 3H), 4.02(dd,



J=10.2, 9.0Hz, 1H), 4.20(dd, J=10.2, 3.3Hz, 1H), 5.11(dd,



J=9.0, 3.3Hz, 1H), 6.43(s, 1H), 6.78(dd, J=8.4, 2.1, 1H),



6.85(d, J=8.7Hz, 2H), 6.88(d, J=2.1Hz, 1H), 6.91(d, J=8.4Hz,



1H), 7.46(d, J=8.7Hz, 2H), 7.30~7.50(m, 5H)



IR(Nujol)3368, 1655, 1612, 1587, 1523, 1489, 1456, 1254,



1225, 1114, 1072, 1014, 941 825, 764 cm−1


I-395
foam



1HNMR(CDCl3)δ 2.48(s, 3H), 2.82(s, 3H), 3.16(s,



3H), 3.22(s, 3H), 3.54(s, 3H), 3.77(s, 3H), 6.85(s, 3H), 7.34~



7.38(m, 2H), 7.38(d, J=8.1Hz, 2H), 7.39(d, J=8.7Hz, 2H),



7.46(d, J=1.8Hz, 1H), 7.46(d, J=8.7Hz, 2H), 7.82(d,



J=8.1Hz, 2H)



IR(Nujol)1597, 1514, 1479, 1464, 1177, 1152, 1085, 969, 883,



846, 797, 729 cm−1


I-396
foam



1HNMR(CDCl3)δ 2.85(s, 3H), 3.14(s, 3H), 3.22(s,



3H), 3.54(s, 3H), 3.77(s, 3H), 6.85(s, 1H), 7.36(m, 2H), 7.39(d,



J=8.7Hz, 2H), 7.45(m, 1H), 7.60(m, 2H), 7.66(d, J=8.7Hz, 2H),



7.74(m, 1H), 7.94(m, 2H)



IR(Nujol)1612, 1584, 1514, 1479, 1451, 1179, 1152, 1085,



969, 949, 846, 797, 737 cm−1

















TABLE 81







I-397
foam



1HNMR(CDCl3)δ 2.73(s, 3H), 3.21(s, 6H), 3.55(s, 3H), 3.77(s,



3H), 5.20(s, 2H), 6.84(s, 1H), 7.16(brs, 1H), 7.22(d, J=8.1Hz,



1H), 7.33, (d, J=2.4Hz, 1H), 7.37(brs, 2H), 7.38(d,



J=8.7Hz, 2H), 7.65(brs, 1H), 7.67(d, J=8.7Hz, 2H)



IR(Nujol)1608, 1519, 1480, 1464, 1176, 1151, 1080, 972,



876, 846, 798 cm−1


I-398
foam



1HNMR(CDCl3)δ 2.91(s, 3H), 3.19(s, 3H), 3.22(s, 3H),



3.54(s, 3H), 3.78(s, 3H), 5.26(s, 2H), 5.34(s, 2H), 7.04(brs, 1H),



7.05(s, 2H), 7.12(brs, 1H), 7.39(d, J=8.7Hz, 2H), 7.36~7.43(m,



3H), 7.67(d, J=8.7Hz, 2H)



IR(Nujol)1608, 1519, 1480, 1463, 1176, 1151, 1079,



972, 876, 799 cm−1


I-399
m.p. 203–205° C.



1HNMR(DMSO-d6)δ 2.87(s, 3H), 3.35(s, 3H), 3.45(s, 3H),



3.52(s, 3H), 3.78(s, 3H), 5.39(s, 2H), 7.07(s, 1H), 7.08(d, J=



3.9Hz, 1H), 7.16(d, J=3.9Hz, 1H), 7.31(dd, J=9.0, 1.8Hz, 1H),



7.33(s, 1H), 7.42(d, J=9.0Hz, 1H), 7.49(d, J=8.7Hz, 2H),



7.74(d, J=8.7Hz, 2H)



IR(Nujol)1609, 1520, 1481, 1455, 1231, 1080, 1013, 984,



947, 878, 832, 798 cm−1


I-400
foam



1HNMR(CDCl3)δ 2.72(s, 3H), 3.14(s, 3H), 3.21(s, 3H),



3.55(s, 3H), 3.77(s, 3H), 5.14(s, 2H), 6.84(s, 1H), 7.11(d, J=



8.7Hz, 1H), 7.34(dd, J=2.1, 8.7Hz, 1H), 7.34(d, J=8.4Hz, 2H),



7.37(d, J=8.4Hz, 2H), 7.41(d, J=2.1Hz, 1H), 7.54(d,



J=8.4Hz, 2H), 7.68(d, J=8.4Hz, 2H)


I-401
foam



1HNMR(CDCl3)δ 2.83(s, 3H), 3.14(s, 3H), 3.22(s, 3H),



3.55(s, 3H), 3.78(s, 3H), 5.26(s, 2H), 6.85(s, 1H), 7.24(d, J=



8.4Hz, 1H), 7.38(d, J=8.4Hz, 1H), 7.41(dd, J=2.1, 8.4Hz, 1H),



7.44(d, J=2.1Hz, 1H), 7.67(d, J=8.4Hz, 2H)



IR(KBr)1609, 1523, 1509, 1481, 1367, 1402, 1178, 1152,



1080, 973, 943, 876, 798 cm−1

















TABLE 82







I-402
foam



1HNMR(CDCl3)δ 2.68(s, 3H), 3.14(s, 3H), 3.21(s, 3H), 3.55(s,



3H), 3.66(s, 2H), 3.71(s, 3H), 3.78(s, 3H), 5.18(s, 2H), 6.84(s,



1H), 7.14(d, J=8.4Hz, 1H), 7.32(d, J=8.7Hz, 1H), 7.35(dd,



J=2.1, 8.7Hz, 1H), 7.37(d, J=8.4Hz, 2H), 7.39(d, J=2.1Hz,



1H), 7.42(d, J=8.4Hz, 2H), 7.67(d, J=8.4Hz, 2H)



IR(KBr)1736, 1610, 1519, 1481, 1365, 1177, 1151, 1079, 876,



817, 798 cm−1


I-403
foam



1HNMR(CDCl3)δ 2.70(s, 3H), 3.16(s, 3H), 3.21(s, 3H),



3.56(s, 3H), 3.78(s, 3H), 5.24(s, 2H), 6.84(s, 1H), 7.18(d, J=



8.4Hz, 1H), 7.36(dd, J=1.5, 8.4Hz, 1H), 7.38(d, J=8.4Hz, 2H),



7.41(d, J=1.5Hz, 1H), 7.46(m, 2H), 7.54(d, J=8.1Hz, 2H), 7.62



(m, 3H), 7.64(d, J=8.1Hz, 2H), 7.68(d, J=8.4Hz, 2H)



IR(KBr)1609, 1519, 1481, 1365, 1177, 1151, 1079, 1014, 876,



818, 797 cm−1


I-404
m.p. 128–130° C.



1HNMR(CDCl3)δ 2.75(s, 3H), 2.92(s, 3H), 3.18(t, J=6.9Hz,



2H), 3.21(s, 3H), 3.55(s, 3H), 3.77(s, 3H), 4.34(t, J=6.9Hz, 2H),



6.81(s, 1H), 7.08(d, J=8.4Hz, 1H), 7.29(m, 2H), 7.32(br.s, 3H),



7.35(dd, J=2.1, 8.4Hz, 1H), 7.38(d, J=8.4Hz, 2H), 7.39(d,



J=2.1Hz, 1H), 7.67(d, J=8.4Hz, 2H)



IR(KBr)1609, 1520, 1481, 1364, 1177, 1151, 1080, 872,



815, 797 cm−1


I-405
foam



1HNMR(CDCl3)δ 1.71(d, J=6.3Hz, 3H), 2.45(br.s, 3H),



3.20(s, 3H), 3.28(s, 3H), 3.53(s, 3H), 3.75(s, 3H), 5.43(q, J=



6.3Hz, 1H), 6.81(s, 1H), 6.90(d, J=8.4Hz, 1H), 7.16(dd, J=2.1,



8.4Hz, 1H), 7.30(m, 1H), 7.36(d, J=2.1Hz, 1H), 7.37(d, J=



8.4Hz, 2H), 7.35–7.41(m, 4H), 7.66(d, J=8.4Hz, 2H)



IR(KBr)1609, 1518, 1480, 1365, 1177, 1151, 1078, 874,



818, 798 cm−1

















TABLE 83







I-406
foam



1HNMR(CDCl3)δ 1.02(t, J=9.0Hz, 3H), 2.04(dq, J=6.3, 9.0Hz,



2H), 2.39(br.s, 3H), 3.20(s, 3H), 3.30(s, 3H), 3.53(s, 3H), 3.75



(s, 3H), 5.18(t, J=6.3Hz, 1H), 6.80(s, 1H), 6.88(d, J=8.1Hz,



1H), 6.92 (m, 1H), 7.14(dd, J=2.4, 8.4Hz, 1H), 7.25–7.40(m,



7H), 7.66(d, J=8.4Hz, 2H)



IR(KBr)1609, 1518, 1480, 1365, 1177, 1151, 1079, 874,



819, 797 cm−1


I-407
foam



1HNMR(CDCl3)δ 2.46(s, 3H), 3.07(s, 3H), 3.20(s, 3H), 3.54(s,



3H), 3.76(s, 3H), 6.33(s, 1H), 6.82(s, 1H), 6.99(d, J=9.0Hz,



1H), 7.19(dd, J=2.1, 9.0Hz, 1H), 7.26–7.40(m, 9H),



7.43–7.47(m, 4H), 7.66(d, J=8.4Hz, 2H)



IR(KBr)1607, 1518, 1481, 1364, 1177, 1151, 1081, 873,



822, 798 cm−1


I-408
m.p. 179–180° C.



1HNMR(CDCl3)δ 1.69(d, J=6.3Hz, 3H), 2.34(br.s, 3H), 2.45(s,



3H), 3.20(s, 3H), 3.27(s, 3H), 3.54(s, 3H), 3.75(s, 3H), 5.40(q,



J=6.3Hz, 1H), 6.81(s, 1H), 6.92(d, J=8.7Hz, 1H), 7.15(d,



J=8.7Hz, 2H), 7.16(dd, J=2.1, 8.4Hz, 1H), 7.27(d, J=



8.7Hz, 1H), 7.35(d, J=2.1Hz, 1H), 7.37(d, J=8.4Hz, 2H),



7.66(d, J=8.4Hz, 2H)



IR(KBr)1609, 1518, 1480, 1365, 1177, 1151, 1078, 874,



819, 797 cm−1


I-409
m.p. 243–244° C.



1HNMR(DMSO-d6)δ 3.30(s, 3H), 3.64(s, 3H), 5.19(s, 2H),



6.39(s, 1H), 6.64(dd, J=1.8, 8.4Hz, 1H), 6.77(d, J=1.8Hz, 1H),



6.83(d, J=8.4Hz, 2H), 6.97(d, J=8.4Hz, 1H), 7.37(t, J=7.5Hz,



1H), 7.44(d, J=8.4Hz, 2H), 7.48(t, J=8.4Hz, 2H), 7.60(d,



J=8.4Hz, 2H), 7.67–7.73(m, 5H)



IR(KBr)3421, 1610, 1523, 1488, 1463, 1403, 1176, 1115,



1072, 821 cm−1


I-410
foam



1HNMR(CDCl3)δ 3.18(t, J=6.9Hz, 2H), 3.45(s, 3H), 3.73(s,



3H), 4.31(t, J=6.9Hz, 2H), 6.44(s, 1H), 6.91(d, J=8.4Hz, 2H),



6.94(br.s, 2H), 7.03(br.s, 1H), 7.23–7.37(m, 5H), 7.53(d,



J=8.4Hz, 2H)



IR(KBr)3434, 1612, 1587, 1523, 1489, 1455, 1403, 1250, 1113,



1070, 1011, 825, 815 cm−1

















TABLE 84







I-411
foam



1HNMR(CDCl3)δ 1.70(d, J=6.0Hz, 3H), 3.44(s, 3H), 3.72(s,



3H), 5.36(q, J=6.0Hz, 1H), 6.42(s, 1H), 6.78(d, J=8.1Hz, 1H),



6.81(dd, J=1.5, 8.7Hz, 1H), 6.91(d, J=8.4Hz, 2H), 7.06(d,



J=1.5Hz, 1H), 7.26–7.42(m, 4H), 7.51(d, J=8.4Hz, 2H)



IR(KBr)3472, 1612, 1587, 1523, 1488, 1454, 1403, 1248,



1113, 1070, 1011, 825, cm−1


I-412
foam



1HNMR(CDCl3)δ 1.03(t, J=7.2Hz, 3H), 1.94(m, 1H), 2.06(m,



1H), 3.43(s, 3H), 3.72(s, 3H), 5.08(dd, J=7.2, 5.4Hz, 1H), 6.43



(s, 1H), 6.73(d, J=8.4Hz, 1H), 6.78(dd, J=1.8, 8.4Hz, 1H), 



6.90(d, J=8.1Hz, 2H), 7.05(d, J=1.8Hz, 1H), 7.25–7.38(m,



5H), 7.51(d, J=8.4Hz, 2H)



IR(KBr)3434 1612, 1522, 1488, 1454, 1403, 1247, 1113, 1070,



1011, 826, 811 cm−1


I-413
foam



1HNMR(CDCl3)δ 3.44(s, 3H), 3.73(s, 3H), 6.25(s, 1H),



6.43(s, 1H), 7.26(m, 2H), 6.90(d, J=8.4Hz, 2H), 7.08(d,



J=2.1Hz, 1H), 7.29–7.43(m, 10H), 7.51(d, J=8.4Hz, 2H)



IR(KBr)3432, 1611, 1523, 1489, 1454, 1402, 1226, 1110,



1069, 1011, 825 cm−1


I-414
foam



1HNMR(CDCl3)δ 1.69(d, J=6.3Hz, 3H), 2.35(s, 3H),



3.44(s, 3H), 3.72(s, 3H), 5.33(q, J=6.3Hz, 1H), 6.42(s, 1H),



6.80(br.s, 2H), 6,90(d, J=8.4Hz, 2H), 7.05(br.s, 1H), 7.18(d,



J=7.8Hz, 2H), 7.29(d, J=7.8Hz, 2H), 7.51(d, J=8.4Hz, 2H)



IR(KBr)3433, 1612, 1522, 1488, 1459, 1403, 1248, 1113,



1069, 1011, 817 cm−1


I-415
m.p. 164–167° C.



1HNMR(CDCl3)δ 3.79(s, 3H), 3.80(s, 3H), 4.81(brs, 1H),



5.29(s, 2H), 6.88–6.94(m, 4H), 7.16(d, J=8.7Hz, 1H), 7.32–7.52



(m, 7H), 7.73(dd, J=2.1, 8.7Hz, 1H), 8.10(d, J=2.1Hz, 1H)



IR(KBr)3513, 2930, 1618, 1529, 1497, 1448, 1387, 1354,



1296, 1257, 1211, 1168, 1091, 1064, 1024 cm−1

















TABLE 85







I-416
m.p. 155–159° C.



1HNMR(CDCl3)δ 3.20(s, 3H), 3.39(s, 3H), 3.82(s, 3H), 3.83(s,



3H), 6.95(s, 1H), 6.96(s, 1H), 7.34–7.38(m, 2H), 7.58–7.64(m,



3H), 7.87(dd, J=2.1, 8.4Hz, 1H), 8.26(d, J=2.1Hz, 1H)



IR(KBr)3433, 2944, 1539, 1519, 1487, 1358, 1216, 1176, 1150,



1086, 1057, 1031 cm−1


I-417
m.p. 124–126° C.



1HNMR(CDCl3)δ 3.19(s, 3H), 3.80(s, 6H), 5.30(s, 2H),



6.93(s, 1H), 6.94(s, 1H), 7.18(d, J=9.0Hz, 1H), 7.32–7.52(m,



7H), 7.59–7.64(m, 2H), 7.73(dd, J=2.1, 9.0Hz, 1H), 8.10(d,



J=2.1Hz, 1H)



IR(KBr)3433, 2937, 1619, 1531, 1491, 1465, 1450, 1358,



1290, 1256, 1211, 1176, 1150, 1088, 1062, 1033 cm−1


I-418
m.p. 151–153° C.



1HNMR(CDCl3)δ 3.18(s, 3H), 3.781(s, 3H), 3.784(s,



3H), 5.14(s, 2H), 6.90–7.00(m, 5H), 7.31–7.50(m, 7H),



7.60–7.65(m, 2H)



IR(KBr)3480, 3383, 2930, 1610, 1523, 1489, 1467, 1383, 1358,



1330, 1211, 1175, 1147, 1024 cm−1


I-419
m.p. 198–200° C.



1HNMR(CDCl3)δ 3.77(s, 6H), 5.13(s, 2H), 6.86–7.00(m,



7H), 7.34–7.50(m, 7H)



IR(KBr)3403, 3327, 1611, 1592, 1525, 1492, 1462, 1444, 1384,



1318, 1273, 1243, 1209, 1178, 1149, 1110, 1058, 1037,



1006 cm−1


I-420
m.p. 168–171° C.



1HNMR(CDCl3)δ 2.99(s, 3H), 3.19(s, 3H), 3.80(s, 3H),



3.81(s, 3H), 5.16(s, 2H), 6.83(brs, 1H), 6.92(s, 1H), 6.96(s, 1H),



7.06(d, J=8.7Hz, 1H), 7.32–7.46(m, 8H), 7.60–7.64(m, 2H),



7.81(d, J=2.1Hz, 1H)



IR(KBr)3403, 3327, 1611, 1592, 1525, 1492, 1462, 1444, 1384,



1318, 1273, 1243, 1209, 1178, 1149, 1110, 1058, 1037,



1006 cm−1


I-421
m.p. 168–171° C.



1HNMR(CDCl3)δ 3.19(s, 3H), 3.80(s, 3H), 3.81(s, 3H),



5.23(s, 2H), 6.93(s, 1H), 6.97(s, 1H), 7.07(d, J=8.7Hz, 1H),



7.33–7.45(m, 8H), 7.61–7.65(m, 2H), 8.58(d, J=2.4Hz, 1H),



8.66(brs, 1H)



IR(KBr)3401, 1723, 1613, 1595, 1549, 1518, 1486, 1385, 1365,



1330, 1299, 1256, 1212, 1151, 1119, 1060, 1037, 1017 cm−1

















TABLE 86







I-422
m.p. 159–160° C.



1HNMR(CDCl3)δ 1.69(s, 3H), 1.74(s, 3H), 2.55(q, J=7.2Hz,



2H), 2.73(s, 3H), 3.22(s, 3H), 3.55(s, 3H), 3.77(s, 3H), 4.06(t,



J=7.2Hz, 2H), 5.24(t, J=7.2Hz, 1H), 6.85(s, 1H), 7.07(d,



J=8.6Hz, 1H), 7.39(d, J=8.7Hz, 2H), 7.55(dd, J=8.6, 2.1Hz,



1H), 7.63(d, J=2.1Hz, 1H), 7.68(d, J=8.7Hz, 2H)



IR(KBr)1515, 1481, 1359, 1325, 1175, 1140, 1079,



870, 799 cm−1


I-423
m.p. 180–182° C.



1HNMR(CDCl3)δ 1.76(s, 3H), 1.81,(s, 3H), 2.71(s, 3H), 3.22(s,



3H), 3.55(s, 3H), 3.78(s, 3H), 4.06(d, J=6.3Hz, 2H), 5.50(t,



J=6.3Hz, 1H), 6.85(s, 1H), 7.09(d, J=8.7Hz, 1H), 7.39(d,



J=8.7Hz, 2H), 7.55(dd, J=8.7, 2.0Hz, 1H), 7.64(d, J=



2.0Hz, 1H), 7.68(d, J=8.7Hz, 2H)



IR(KBr)1514, 1479, 1360, 1241, 1174, 1132, 1078,



866, 800 cm−1


I-424
m.p. 176–178° C.



1HNMR(CDCl3)δ 2.64(s, 3H), 3.22(s, 3H), 3.55(s, 3H),



3.78(s, 3H), 5.26(s, 2H), 6.85(s, 1H), 7.14(d, J=8.6Hz, 1H),



7.33–7.48(m, 7H), 7.54(dd, J=8.6, 2.1Hz, 1H),



7.66–7.70(m, 3H)



IR(KBr)1517, 1482, 1367, 1327, 1178, 1150, 1135,



1081, 878, 797 cm−1


I-425
m.p. 199–200° C.



1HNMR(CDCl3)δ 2.37(s, 3H), 2.63(s, 3H), 3.21(s, 3H),



3.55(s, 3H), 3.78(s, 3H), 5.21(s, 2H), 6.84(s, 1H), 7.13(d, J=



8.7Hz, 1H), 7.20(d, J=8.0Hz, 2H), 7.34(d, J=8.0Hz, 2H), 7.38



(d, J=9.0Hz, 2H), 7.53(dd, J=8.7, 1.8Hz, 1H), 7.66(d,



J=1.8Hz, 1H), 7,68(d, J=9.0Hz, 2H)



IR(KBr)1517, 1481, 1366, 1326, 1255, 1177, 1151, 1082,



871, 798 cm−1


I-426
amorphous



1HNMR(CDCl3)δ 1.68(s, 3H), 1.73(s, 3H), 2.54(q,



J=7.2Hz, 2H), 3.44(s, 3H), 3.75(s, 3H), 4.05(t, J=7.2Hz, 2H),



5.07(s, 1H), 5.24(t, J=7.2Hz, 1H), 6.02(s, 1H), 6.45(s, 1H), 6.92



(d, J=8.6Hz, 2H), 7.41(d, J=8.6Hz, 1H), 7.53(d, J=8.6Hz,



2H), 7.59(dd, J=8.6, 2.0Hz, 1H), 7.63(d, J=2.0Hz, 1H)



IR(CHCl3)3595, 3506, 1614, 1523, 1489, 1326, 1281,



1258, 1122, 1079, 1057 cm−1

















TABLE 87







I-427
m.p. 180–182° C.



1HNMR(CDCl3)δ 1.75(s, 3H), 1.80(s, 3H), 3.44(s, 3H), 3.76(s,



3H), 4.66(d, J=6.6Hz, 2H), 4.87(s, 1H), 5.52(t, J=6.6Hz, 1H),



6.02(s, 1H), 6.46(s, 1H), 6.93(d, J=8.9Hz, 2H), 7.06(d, J=8.4Hz,



1H), 7.53(d, J=8.9Hz, 2H), 7.59(dd, J=8.4, 2.1Hz, 1H), 7.71(d,



J=2.1hz, 1H),



IR(KBr)3406, 1615, 1522, 1488, 1399, 1324, 1280, 1256, 1138,



1116, 1076, 1054, 996, 835, 826 cm−1


I-428
m.p. 133–135° C.



1HNMR(CDCl3)δ 3.44(s, 3H), 3.75(s, 3H), 4.87(s, 1H), 5.23(s,



2H), 6.03(s, 1H), 6.46(s, 1H), 6.93(d, J=8.6Hz, 2H), 7.11(d,



J=8.4Hz, 1H), 7.32–7.49(m, 5H), 7.53(d, J=8.6Hz, 2H), 7.60



(dd, J=8.4, 2.1Hz, 1H), 7.75(d, J=2.1Hz, 1H),



IR(KBr)3397, 1612, 1523, 1489, 1400, 1321, 1257, 1132,



1084, 1056, 1002, 832 cm−1


I-429
m.p. 174–176° C.



1HNMR(CDCl3)δ 2.37(s, 3H), 3.44(s, 3H), 3.75(s, 3H),



4.88(s, 1H), 5.18(s, 2H), 6.02(s, 1H), 6.45(2, 1H), 6.93(d, J=



8.6Hz, 2H), 7.11(d, J=8.4Hz, 1H), 7.21(d, J=8.1Hz, 2H), 7.36



(d, J=8.1Hz, 2H), 7.53(d, J=8.6Hz, 2H), 7.59(dd, J=



8.4, 2.1Hz, 1H), 7.74(d, J=2.1Hz, 1H),



IR(KBr)3481, 3376, 1616, 1520, 1491, 1327, 1260,



1119, 1081, 1004, 827 cm−1


I-430
1HNMR(CDCl3)δ 2.37(s, 3H), 2.54(s, 3H), 2.68(s, 3H), 3.12(s,



3H), 3.54(s, 3H), 3.77(s, 3H), 5.14(s, 2H), 6.85(s, 1H),



7.12–7.24(m, 3H), 7.30–7.44(m, 6H), 7.53–7.59(m, 2H)



IR(CHCl3)1608, 1517, 1476, 1367, 1117, 1080,



1013, 970, 876 cm−1


I-431
m.p. 164–168° C.



1HNMR(CDCl3)δ 1.76(s, 3H), 1.82(s, 3H), 2.54(s, 3H), 3.47(s,



3H), 3.75(s, 3H), 4.62(d, J=6.9Hz, 2H), 5.53(m, 1H), 5.69(s,



1H), 5.89(s, 1H), 6.46(s, 1H), 6.92–7.08(m, 3H), 7.30–7.38



(m, 2H), 7.55–7.62(m, 2H)



IR(CHCl3)3518, 2968, 1584, 1516, 1483, 1460, 1414,



1388, 1310, 1289, 1243, 1114, 1069, 1011, 936, 818 cm−1


I-432
m.p. 179–181° C.



1HNMR(CDCl3)δ 2.39(s, 3H), 2.54(s, 3H), 3.46(s, 3H),



3.74(s, 3H), 5.10(s, 2H), 5.67(s, 1H), 5.89(s, 1H), 6.46(s, 1H),



6.81 (dd, J=2.1, 8.4Hz, 1H), 7.03(d, J=8.4Hz, 1H), 7.08(d,



J=2.1Hz, 1H), 7.20–7.26(m, 2H), 7.31–7.37(m, 4H),



7.55–7.61(m, 2H)



IR(CHCl3)3524, 2930, 1585, 1517, 1483, 1460, 1414,



1389, 1310, 1289, 1245, 1114, 1090, 1070, 1009,



937, 818 cm−1

















TABLE 88







I-433
m.p. 111–112° C.



1HNMR(CDCl3)δ 1.76(d, J=0.6Hz, 3H), 1.81(d, J=0.9Hz, 3H),



2.69(s, 3H), 3.52(s, 3H), 3.78(s, 3H), 4.63(t, J=6.6Hz, 2H), 5.53



(m, 1H), 6.84(s, 1H), 7.02–7.25(m, 5H), 7.56–7.65(m, 2H)



IR(CHCl3)2932, 1607, 1520, 1481, 1368, 1266, 1080, 1012, 961,



907, 836, 812cm−1


I-434
m.p. 97–101° C.



1HNMR(CDCl3)δ 1.69(s, 3H), 1.75(d, J=0.9Hz, 3H), 2.48–2.58



(m, 5H), 3.46(s, 3H), 3.47(s, 3H), 4.06(t, J=6.9Hz, 2H), 5.22(m,



1H), 5.67(s, 1H), 5.88(s, 1H), 6.46(s, 1H), 6.92–6.97(m, 2H), 7.05



(m, 1H), 7.30–7.38(m, 2H), 7.55–7.62(m, 2H)



IR(CHCl3)3518, 2928, 1584, 1517, 1483, 1414, 1388, 1290, 1246,



1114, 1090, 1070, 1011, 937, 907, 818cm−1


I-435
m.p. 127–129° C.



1HNMR(CDCl3)δ 1.68(s, 3H), 1.74(d, J=1.2Hz, 3H), 2.50–2.60



(m, 2H), 2.71(s, 3H), 3.52(s, 3H), 3.77(s, 3H), 4.04(t, J=7.2Hz,



2H), 5.23(m, 1H), 6.83(s, 1H), 7.00–7.21(m, 5H), 7.57–7.64



(m, 2H)



IR(CHCl3)2930, 1607, 1520, 1481, 1368, 1266, 1080, 1012, 960,



836, 812cm−1


I-436
m.p. 159–161° C.



1HNMR(CDCl3)δ 2.36(s, 3H), 2.57(s, 3H), 3.52(s, 3H), 3.77(s,



3H), 5.16(s, 2H), 6.83(s, 1H), 7.05–7.24(m, 7H), 7.31–7.37(m,



2H), 7.56–7.65(m, 2H)



IR(CHCl3)1520, 1481, 1368, 1267, 1131, 1080, 1012, 960, 836



cm−1


I-437
m.p. 120–124° C.



1HNMR(CDCl3)δ 1.76(d, J=0.6Hz, 3H), 1.81(d, J=0.6Hz, 3H),



3.43(s, 3H), 3.67(s, 3H), 4.63(d, J=6.6Hz, 2H), 5.56(m, 1H), 5.96



(s, 1H), 6.44(s, 1H), 7.00–7.24(m, 5H), 7.57–7.66(m, 2H)



IR(CHCl3)3522, 2930, 1586, 1518, 1484, 1415, 1390, 1311, 1290,



1248, 1115, 1090, 1071, 1012, 938, 818cm−1

















TABLE 89







I-438
m.p. 140.5–141.5° C.



1HNMR(CDCl3)δ 2.37(s, 3H), 3.43(s, 3H), 3.75(s, 3H), 5.14(s,



2H), 5.97(s, 1H), 6.44(s, 1H), 7.04–7.28(m, 7H), 7.36(d, J=8.1Hz,



1H), 7.57–7.65(m, 2H)



IR(CHCl3)3496, 2932, 1613, 1520, 1488, 1460, 1391, 1313, 1267,



1113, 1069, 1010, 934, 825cm−1


I-439
m.p. 76.5–77.5° C.



1HNMR(CDCl3)δ 1.68(s, 3H), 1.74(d, J=0.9Hz, 3H), 2.49–2.60



(m, 2H), 3.43(s, 3H), 3.75(s, 3H), 4.05(t, J=7.2Hz, 2H), 5.23(m,



1H), 5.96(s, 1H), 6.44(s, 1H), 6.99–7.28(m, 5H), 7.57–7.66



(m, 2H)



IR(CHCl3)3498, 2930, 1613, 1521, 1489, 1391, 1310, 1267, 1113,



1070, 1011, 934, 825cm−1


I-440
m.p. 174–176° C.



1HNMR(CDCl3)δ 2.80(s, 3H), 3.46(s, 3H), 3.76(s, 3H), 5.16(s,



2H), 5.71(s, 1H), 5.88(s, 1H), 6.47(s, 1H), 6.95(dd, J=1.8, 8.4Hz,



1H), 7.04(d, J=8.4Hz, 1H), 7.08(d, J=1.8Hz, 1H), 7.34–7.49(m,



5H), 7.72–7.85(m, 4H)



IR(CHCl3)3518, 1587, 1516, 1483, 1459, 1415, 1387, 1290, 1114,



1070, 1041, 1011, 936, 821cm−1


I-441
m.p. 199–202° C.



1HNMR(d6-DMSO)δ 3.28(s, 3H), 3.34(s, 3H), 3.67(s, 3H), 5.14(s,



2H), 6.52(s, 1H), 6.66(dd, J=2.1, 8.4Hz, 1H), 6.79(d, J=2.1Hz,



1H), 6.97(d, J=8.4Hz, 1H), 7.30–7.56(m, 5H), 7.86–7.93(m, 2H),



7.98–8.04(m, 2H), 8.65–9.02(brs, 2H)



IR(KBr)3487, 3413, 3004, 1597, 1518, 1500, 1482, 1456, 1360,



1310, 1281, 1231, 1146, 1118, 1090, 1068, 1016, 1004, 961cm−1


I-442
m.p. 80–84° C.



1HNMR(CDCl3)δ 1.15(t, J=7.2Hz, 3H), 3.60(q, J=7.2Hz, 2H),



3.75(s, 3H), 5.03(s, 1H), 5.15(s, 2H), 5.69(s, 1H), 5.98(s, 1H),



6.45(s, 1H), 6.88–6.94(m, 2H), 6.96(dd, J=2.1, 8.1Hz, 1H), 7.02



(d, J=8.1Hz, 1H), 7.10(d, J=2.1Hz, 1H), 7.34–7.49(m, 5H), 7.51–



7.59(m, 2H)



IR(CHCl3)3528, 1612, 1521, 1488, 1454, 1412, 1383, 1286, 1246,



1113, 1069, 1023, 886, 825cm−1

















TABLE 90







I-443
m.p. 168–169° C.



1HNMR(CDCl3)δ 1.14(t, J=6.9Hz, 3H), 2.66(s, 3H), 3.13(s, 3H),



3.20(s, 3H), 3.72(q, J=6.9Hz, 2H), 3.78(s, 3H), 5.19(s, 2H), 6.84



(s, 1H), 7.15(d, J=8.4Hz, 1H), 7.31–7.49(m, 9H), 7.66–7.73



(m, 5H)



IR(CHCl3)1517, 1479, 1369, 1148, 1117, 1082, 969, 873cm−1


I-444
m.p. 192–194° C.



1HNMR(CDCl3)δ 3.13(s, 3H), 3.44(s, 3H), 3.63(s, 3H), 3.76(s,



3H), 5.14(br, 1H), 5.19(s, 2H), 6.81–6.84(m, 2H), 6.94(s, 1H),



7.14(d, J=8.4Hz, 1H), 7.22–7.25(m, 2H), 7.37–7.50(m, 5H), 7.57



(dd, J=8.7, 2.1Hz, 1H), 7.67(d, J=2.1Hz, 1H)



IR(CHCl3)3595, 3441, 1730, 1613, 1522, 1472, 1371, 1291, 1258,



1172, 1164, 1003, 972, 961, 904, 838cm−1


I-445
m.p. 179–180° C.



1HNMR(CDCl3)δ 1.77(s, 3H), 1.82(s, 3H), 2.31(s, 3H), 3.24(s,



3H), 3.45(s, 3H), 3.58(s, 3H), 3.76(s, 3H), 4.64(d, J=6.9Hz, 2H),



6.95(s, 1H), 7.06–7.13(m, 3H), 7.35–7.38(m, 2H), 7.57(dd, J=8.4,



2.4Hz, 1H), 7.64(d, J=2.4Hz, 1H)



IR(CHCl3)2938, 1732, 1614, 1599, 1518, 1470, 1445, 1370, 1345,



1290, 1228, 1200, 1169, 1116, 1081, 1003, 973, 905, 846,



829cm−1


I-446
m.p. 137–138° C.



1HNMR(CDCl3)δ 3.13(s, 3H), 3.45(s, 3H), 3.59(s, 3H), 3.77(s,



3H), 3.88(s, 3H), 4.23(s, 2H), 5.19(s, 2H), 6.96(s, 1H), 7.15(d,



J=8.7Hz, 1H), 7.35–7.50(m, 9H), 7.60(dd, J=8.7, 2.4Hz, 1H), 7.67



(d, J=2.4Hz, 1H)



IR(CHCl3)2954, 1750, 1734, 1614, 1516, 1471, 1387, 1372, 1345,



1291, 1258, 1173, 1147, 1118, 1081, 1064, 1004, 877cm−1


I-447
m.p. 184–185° C.



1HNMR(CDCl3)δ 3.44(s, 3H), 3.60(s, 3H), 3.74(s, 3H), 4.70(br,



2H), 5.17(s, 2H), 6.95–7.02(m, 4H), 7.17(dd, J=8.4, 2.1Hz, 1H),



7.25(s, 1H), 7.31–7.34(d, J=8.7Hz, 2H), 7.38–7.47(m, 5H)



IR(CHCl3)3541, 2937, 1776, 1733, 1608, 1519, 1474, 1442, 1344,



1291, 1157, 1130, 1085, 1063, 1002, 900, 862, 835cm−1

















TABLE 91







I-448
m.p. 176–178° C.



1HNMR(CDCl3)δ 3.12(s.3H), 3.44(s, 3H), 3.60(s, 3H), 3.76(s,



3H), 3.83(s, 3H), 4.66(s, 2H), 5.19(s, 2H), 6.91–6.96(m, 3H), 7.14



(d, J=8.4Hz, 1H), 7.28–7.49(m, 7H), 7.57(dd, J=8.7, 2.4Hz, 1H),



7.67(d, J=2.4Hz, 1H)



IR(CHCl3)2953, 2939, 1758, 1732, 1610, 1519, 1471, 1444, 1371,



1345, 1291, 1177, 1117, 1085, 1064, 1002, 973, 961, 904,



837cm−1


I-449
m.p. 124–126° C.



1HNMR(CDCl3)δ 1.69(s, 3H), 1.74(d, J=0.9Hz, 3H), 2.31(s, 3H),



2.53–2.60(m, 2H), 3.23(s, 3H), 3.44(s, 3H), 3.58(s, 3H), 3.76(s,



3H), 4.09(t, J=6.6Hz, 2H), 5.22(m 1H), 6.95(s, 1H), 7.07(d, J=8.4



Hz, 1H), 7.10–7.13(m, 2H), 7.34–7.37(m, 2H), 7.57(dd, J=9.0, 2.4



Hz, 1H), 7.64(d, J=2.4Hz, 1H)



IR(CHCl3)2938, 1732, 1614, 1518, 1469, 1445, 1370, 1291, 1257,



1170, 1167, 1081, 1004, 973, 961, 906, 846cm−1


I-450
m.p. 160–161° C.



1HNMR(CDCl3)δ 1.69(s, 3H), 1.74(d, J=0.9, 3H), 2.53–2.60(m,



2H), 3.23(s, 3H), 3.44(s, 3H), 3.62(s, 3H), 3.76(s, 3H), 4.08(d, J=



6.6Hz, 2H), 4.91(br, 1H), 5.20–5.25(m, 1H), 6.83–6.86(m, 2H),



6.94(s, 1H), 7.06(d, J=8.7Hz, 2H), 7.23–7.26(m, 2H), 7.57(dd,



J=8.7, 2.4Hz, 1H), 7.64(d, J=2.4Hz, 1H)



IR(CHCl3)3595, 3448, 2937, 1730, 1613, 1522, 1469, 1445, 1370,



1345, 1292, 1260, 1172, 1117, 1081, 1064, 1003, 973, 864,



837cm−1


I-451
m.p. 182–184° C.



1HNMR(CDCl3)δ 1.70(d, J=0.6Hz, 3H), 1.81(d, J=0.9Hz, 3H),



3.24(s, 3H), 3.45(s, 3H), 3.63(s, 3H), 3.75(s, 3H), 4.64(d, J=6.6



Hz, 2H), 5.48–5.54(m, 1H), 5.76(br, 1H), 6.78–6.82(m, 2H), 6.95



(s, 1H), 7.08(d, J=8.7Hz, 1H), 7.19–7.24(m, 2H), 7.56(dd, J=8.7,



2.4Hz, 1H), 7.64(d, J=2.4Hz, 1H)



IR(CHCl3)3595, 3445, 2939, 1730, 1613, 1522, 1471, 1445, 1369,



1345, 1291, 1257, 1172, 1116, 1081, 1064, 1002, 973, 904,



838cm−1


I-452
m.p. 250–253° C. (dec.)



1HNMR(CD3OD)δ 3.41(s, 3H), 3.71(s, 3H), 4.58(s, 2H), 5.21(s,



2H), 6.29–6.95(m, 3H), 7.02–7.03(m, 2H), 7.17(s, 1H), 7.26–7.41



(m, 5H), 7.49–7.52(m, 2H)



IR(KBr)3424, 2933, 2553, 1709, 1608, 1519, 1467, 1383, 1333,



1291, 1229, 1129, 1084, 1060, 1001, 915, 861, 841, 727, 697cm−1

















TABLE 92







I-453
foam



1HNMR(CDCl3)δ 1.69(s, 3H), 1.75(d, J=1.2Hz, 3H), 2.51–2.58



(m, 2H), 3.43(s, 3H), 3.62(s, 3H), 3.75(s, 3H), 4.08(t, J=6.9Hz,



2H), 4.85(br, 1H), 5.23(m, 1H), 5.71(br, 1H), 6.82–6.85(m, 2H),



6.90–6.94(m, 2H), 7.16(dd, J=8.4, 2.1Hz, 1H), 7.23–7.26(m, 3H)



IR(CHCl3)3596, 3541, 2936, 1730, 1612, 1590, 1522, 1470, 1395,



1345, 1290, 1258, 1173, 1130, 1081, 1063, 1004, 861, 836cm−1


I-454
m.p. 166–167° C.



1HNMR(CDCl3)δ 1.77(s, 3H), 1.82(s, 3H), 3.48(s, 3H), 3.75(s,



3H), 4.64(d, J=6.6Hz, 2H), 5.51–5.55(m, 1H), 5.75(br, 1H), 6.77–



6.80(m, 2H), 6.93–6.96(m, 2H), 7.17(dd, J=8.1, 2.1Hz, 1H), 7.23–



7.28(m, 3H)



IR(KBr)3447, 2937, 1590, 1559, 1522, 1473, 1382, 1338, 1295,



1259, 1131, 1080, 1059, 999, 918, 862, 837, 815, 791, 754cm−1


I-455
m.p. 168–170° C.



1HNMR(CD3OD)δ 1.68(s, 3H), 1.74(s, 3H), 2.50–2.58(m, 2H),



3.41(s, 3H), 3.73(s, 3H), 4.05(t, J=6.9Hz, 2H), 5.29(m, 1H),



6.76–6.79(m, 2H), 6.98–7.17(m, 6H)



IR(KBr)3411, 2964, 2936, 1685, 1613, 1590, 1523, 1472, 1379,



1293, 1259, 1229, 1131, 1082, 1061, 1000, 962, 861, 838, 814,



791, 754, 529cm−1


I-456
m.p. 153–155° C.



1HNMR(CDCl3)δ 3.14(s, 3H), 3.50(s, 3H), 3.77(s, 3H), 5.20(s,



2H), 7.10–7.28(m, 6H), 7.38–7.50(m, 5H), 7.56(dd, J=8.4, 2.1Hz,



1H), 7.65(d, J=2.1Hz, 1H), 9.98(s, 1H)



IR(CHCl3)2938, 2843, 1697, 1604, 1590, 1517, 1469, 1372, 1331,



1293, 1254, 1172, 1159, 1123, 1093, 1005, 963, 818cm−1


I-457
m.p. 143–145° C.



1HNMR(CDCl3)δ 1.77(s, 3H), 1.83(s, 3H), 3.44(s, 3H), 3.63(s,



3H), 3.75(s, 3H), 4.63(d, J=6.6Hz, 2H), 5.53(m, 1H), 5.72(br, 1H),



6.82–6.85(m, 2H), 6.92–6.95(m, 2H), 7.16(dd, J=8.4, 2.4Hz, 1H),



7.23–7.26(m, 3H)



IR(CHCl3)3595, 3537, 2938, 1729, 1612, 1591, 1522, 1473, 1395,



1344, 1290, 1258, 1173, 1129, 1081, 1063, 1003, 900, 862,



836cm−1

















TABLE 93







I-458
powder



1HNMR(CDCl3)δ 2.37(s, 3H), 3.08(s, 3H), 3.11(s, 3H), 3.21(s,



3H), 3.51(s, 3H), 3.52(s, 3H), 5.26(s, 2H), 7.19–7.23(m, 2H),



7.36–7.43(m, 4H), 7.45–7.50(m, 2H), 7.82(d, J=2.1Hz, 1H), 7.98



(d, J=2.1Hz, 1H)



IR(CHCl3)3033, 2942, 1543, 1377, 1220, 1181, 1153, 1034cm−1


I-459
m.p. 182–187° C. (dec.)



1HNMR(CDCl3)δ 2.36(s, 3H), 2.73(s, 3H), 3.16(s, 3H), 3.22(s,



3H), 3.43(s, 3H), 3.47(s, 3H), 5.08(s, 2H), 6.85(brs, 1H), 6.92(brs,



1H), 7.17–7.21(m, 2H), 7.32–7.38(m, 2H), 7.39–7.44(m, 2H),



7.50–7.55(m, 2H)



IR(CHCl3)3030, 2939, 1618, 1599, 1513, 1468, 1416, 1372, 1178,



1150, 1031cm−1


I-460
powder



1HNMR(CDCl3)δ 2.38(s, 3H), 2.83(s, 3H), 3.05(s, 3H), 3.22(s,



3H), 3.56(s, 3H), 3.80(s, 3H), 3.91(s, 3H), 5.13(s, 2H), 6.86(s,



1H), 7.20–7.24(m, 2H), 7.37–7.46(m, 4H), 7.65–7.70(m, 3H), 7.89



(d, J=2.1Hz, 1H)



IR(CHCl3)3032, 2940, 1728, 1473, 1373, 1232, 1179, 1150,



1085cm−1


I-461
amorphous



1HNMR(CDCl3)δ 3.78(s, 6H), 5.16(s, 2H), 5.31(d, J=3.6Hz, 1H),



5.72(s, 1H), 6.91(s, 1H), 6.94(s, 1H), 6.99(d, J=8.2Hz, 1H), 7.04(t,



J=8.6Hz, 1H), 7.08(dd, J=8.2, 2.1Hz, 1H), 7.22(d, J=2.1Hz, 1H),



7.25(ddd, J=8.6, 1.8, 0.9Hz, 1H), 7.34–7.46(m, 6H)



IR(CHCl3)3577, 3548, 1526, 1495, 1280, 1635 cm−1


I-462
m.p. 153–155° C.



1HNMR(CDCl3)δ 3.12(s, 3H), 3.26(s, 3H), 3.80(s, 3H), 3.81(s,



3H), 5.18(s, 2H), 6.91(s, 1H), 6.94(s, 1H), 7.12(d, J=8.4Hz, 1H),



7.36–7.50(m, 8H), 7.59(d, J=1.8Hz, 1H)



IR(CHCl3)1494, 1367, 1212, 1180, 1116, 872, 808 cm−1

















TABLE 94







I-463
m.p. 125–127° C.



1HNMR(CDCl3)δ 1.77(s, 3H), 1.82(s, 3H), 3.23(s, 3H), 3.27(s,



3H), 3.80(s, 3H), 3.82(s, 3H), 4.64(d, J=6.7Hz, 2H), 5.51(t, J=6.7



Hz, 1H), 6.91(s, 1H), 6.95(s, 1H), 7.06(d, J=8.7Hz, 1H), 7.37(dd,



J=8.7, 1.9Hz, 1H), 7.40–7.47(m, 2H), 7.50(d, J=2.4Hz, 1H),



7.57(d, J=1.9Hz, 1H)



IR(KBr)1523, 1496, 1370, 1213, 1175, 1116, 1035, 977, 832,



807cm−1


I-464
m.p. 149–151° C.



1HNMR(CDCl3)δ 1.69(s, 3H), 1.74(s, 3H), 2.55(q, J=7.0Hz, 2H),



3.21(s, 3H), 3.26(s, 3H), 3.80(s, 3H), 3.81(s, 3H), 4.07(t, J=7.0Hz,



2H), 5.21(t, J=7.0Hz, 1H), 6.91(s, 1H), 6.94(s, 1H), 7.05(d, J=8.4



Hz, 1H), 7.37(dd, J=8.4, 2.1Hz, 1H), 7.40–7.47(m, 2H), 7.50(d, J=



2.1Hz, 1H), 7.57(d, J=2.1Hz, 1H)



IR(KBr)1523, 1495, 1368, 1212, 1176, 1116, 1035, 976, 832,



806cm−1


I-465
m.p. 148–150° C.



1HNMR(CDCl3)δ 2.38(s, 3H), 3.11(s, 3H), 3.26(s, 3H), 3.80(s,



3H), 3.81(s, 3H), 5.13(s, 2H), 6.91(s, 1H), 6.94(s, 1H), 7.12(d, J=



8.4Hz, 1H), 7.22(d, J=7.8Hz, 2H), 7.35(d, J=7.8Hz, 2H), 7.37(dd,



J=8.4, 1.8Hz, 1H), 7.40–7.50(m, 3H), 7.59(d, J=1.8Hz, 1H)



IR(KBr)1523, 1490, 1370, 1181, 1115, 971, 868, 806cm−1


I-466
m.p. 109–112° C.



1HNMR(CDCl3)δ 1.76(s, 3H), 1.82(s, 3H), 3.79(s, 6H), 4.62(d,



J=6.9Hz, 2H), 5.26(d, J=3.9Hz, 1H), 5.52(t, J=6.9Hz, 1H), 5.72(s,



1H), 6.91(s, 1H), 6.93(d, J=8.6Hz, 1H), 6.94(s, 1H), 7.04(t, J=8.7



Hz, 1H), 7.07(dd, J=8.6, 2.1Hz, 1H), 7.19(d, J=2.1Hz, 1H), 7.25



(ddd, J=8.7, 1.8, 0.9Hz, 1H), 7.37(dd, J=12.0, 1.8Hz, 1H)



1R(CHCl3)3578, 3542, 1526, 1495, 1280, 1055, 1035cm−1

















TABLE 95 







I-467
amorphous



1HNMR(CDCl3)δ 2.39(s, 3H), 3.79(s, 6H), 5.11(s, 2H), 5.40(brs,



1H), 5.73(s, 1H), 6.91(s, 1H), 6.94(s, 1H), 6.99(d, J=8.4Hz, 1H),



7.04(t, J=8.7Hz, 1H), 7.08(dd, J=8.4, 2.1Hz, 1H), 7.21(d, J=2.1Hz,



1H), 7.23(d, J=7.7Hz, 2H), 7.25(ddd, J=8.7, 2.1, 1.2Hz, 1H), 7.34



(d, J=7.7Hz, 2H), 7.37(dd, J=11.7, 2.1Hz, 1H)



IR(CHCl3)3577, 3545, 1526, 1495, 1280, 1055, 1035, 868cm−1


I-468
amorphous



1HNMR(CDCl3)δ 1.69(s, 3H), 1.75(s, 3H), 2.53(q, J=7.0Hz, 2H),



3.78(s, 3H), 3.79(s, 3H), 4.07(t, J=7.2Hz, 2H), 5.22(t, J=7.0Hz,



1H), 5.27(d, J=3.9Hz, 1H), 5.71(s, 1H), 6.91(s, 1H), 6.91(d, J=8.6



Hz, 1H), 6.94(s, 1H), 7.04(t, J=8.4Hz, 1H), 7.06(dd, J=8.6, 2.1Hz,



1H), 7.19(d, J=2.1Hz, 1H), 7.25(ddd, J=8.4, 1.9, 1.1Hz, 1H), 7.37



(dd, J=12.0, 1.9Hz, 1H)



IR(CHCl3)3578, 1526, 1495, 1280, 1055, 1035cm−1


I-469
m.p. 190–191° C.



1HNMR(CDCl3)δ 2.38(s, 3H), 3.11(s, 3H), 3.19(s, 3H), 3.80(s,



6H), 5.13(s, 2H), 6.92(s, 1H), 6.94(s, 1H), 7.12(d, J=8.7Hz, 1H),



7.22(d, J=7.8Hz, 1H), 7.32–7.37(m, 4H), 7.49(dd, J=2.1, 8.4Hz,



1H), 7.59(d, J=1.8Hz, 1H), 7.60–7.65(m, 2H)



IR(KBr)3600–2800(br), 1521, 1492, 1468, 1386, 1366, 1336,



1292, 1272, 1259, 1202, 1174, 1150, 1113cm−1


I-470
m.p. 147–148° C.



1HNMR(CDCl3)δ 2.37(s, 3H), 3.19(s, 3H), 3.79(s, 3H), 3.80(s,



3H), 5.16(s, 2H), 6.92(s, 1H), 6.93(s, 1H), 7.06(t, J=8.7Hz, 1H),



7.20–7.27(m, 3H), 7.32–7.41(m, 5H), 7.60–7.64(m, 2H)



IR(KBr)3600–2800(br), 1523, 1492, 1462, 1454, 1379, 1359,



1299, 1278, 1264, 1210, 1175, 1151, 1129, 1054, 1031, 1009cm−1


I-471
m.p. 170–172° C.



1HNMR(CDCl3)δ 3.19(s, 3H), 3.24(s, 3H), 3.79(s, 3H), 3.80(s,



3H), 5.12(s, 2H), 6.92(s, 1H), 6.94(s, 1H), 7.11(d, J=8.7Hz, 1H),



7.26–7.30(m, 2H), 7.32–7.37(m, 2H), 7.47(dd, J=2.4, 8.4Hz, 1H),



7.61–7.64(m, 3H), 7.74–7.80(m, 1H), 8.61–8.63(m, 1H)



IR(KBr)3600–2800(br), 1522, 1491, 1462, 1361, 1296, 1264,



1212, 1177, 1149, 1115, 1030cm−1

















TABLE 96







I-472
m.p. 174–175° C.



1HNMR(CDCl3)δ 3.19(s, 3H), 3.79(s, 3H), 3.80(s, 3H), 5.33(s,



2H), 6.92(s, 1H), 6.93(s, 1H), 7.07(d, J=8.7Hz, 1H), 7.23–7.28(m,



2H), 7.32–7.37(m, 2H), 7.41(dd, J=1.8, 12.6Hz, 1H), 7.60–7.64



(m, 3H), 7.73–7.79(m, 1H), 8.60–8.63(m, 1H)



IR(KBr)3600–2800(br), 1524, 1491, 1464, 1380, 1361, 1302,



1267, 1209, 1172, 1149, 1130, 1034, 1024, 1008cm−1


I-473
m.p. 118.5–119.5° C.



1HNMR(CDCl3)δ 1.77(s, 3H), 1.80(d, J=0.9Hz, 3H), 3.78(s, 3H),



3.79(s, 3H), 4.63(d, J=6.9Hz, 2H), 5.52–5.57(m, 1H), 6.73–6.78



(m, 2H), 6.91(s, 1H), 6.93(s, 1H), 7.02(t, J=8.7Hz, 1H), 7.25–7.30



(m, 1H), 7.35–7.43(m, 3H)



IR(KBr)3600–2800(br), 1625, 1527, 1491, 1461, 1449, 1378,



1298, 1279, 1259, 1207, 1184, 1125, 1055, 1031cm−1


I-474
m.p. 156–158° C.



1HNMR(CDCl3)δ 1.77(s, 3H), 1.81(s, 3H), 3.08(s, 3H), 3.80(s,



3H), 3.81(s, 3H), 4.64(d, J=6.6Hz, 2H), 5.52–5.58(m, 1H), 6.43



(brs, 1H), 6.93(s, 1H), 6.94(s, 1H), 7.03(t, J=8.4Hz, 1H), 7.26–



7.30(m, 3H), 7.37(dd, J=1.8, 12.6Hz, 1H), 7.57–7.61(m, 2H)



IR(KBr)3600–2800(br), 1526, 1495, 1463, 1382, 1325, 1300,



1267, 1210, 1156, 1139, 1129, 1054, 1032cm−1


I-475
m.p. 158–160° C.



1HNMR(CDCl3)δ 1.77(s, 3H), 1.81(s, 3H), 3.80(s, 6H), 4.64(d,



J=6.6Hz, 2H), 4.73(brs, 2H), 5.53–5.57(m, 1H), 6.51(brs, 1H),



6.93(s, 1H), 6.94(s, 1H), 7.03(t, J=8.7Hz, 1H), 7.26–7.31(m, 3H),



7.37(dd, J=2.1, 12.6Hz, 1H), 7.57–7.61(m, 2H)



IR(KBr)3600–2800(br), 1527, 1495, 1462, 1395, 1326, 1299,



1264, 1208, 1170, 1130, 1054, 1031cm−1


I-476
m.p. 138–140° C.



1HNMR(CDCl3)δ 1.77(s, 3H), 1.81(s, 3H), 2.21(s, 3H), 3.78(s,



3H), 3.80(s, 3H), 4.63(d, J=6.9Hz, 2H), 5.53–5.57(m, 1H), 6.93(s,



1H), 6.94(s, 1H), 7.03(t, J=8.4Hz, 1H), 7.20(brs, 1H), 7.26–7.30



(m, 1H), 7.37(dd, J=2.1, 12.6Hz, 1H), 7.56(m, 4H)



IR(KBr)3600–2800(br), 1666, 1604, 1527, 1494, 1463, 1448,



1379, 1317, 1299, 1264, 1209, 1130, 1055, 1032cm−1

















TABLE 97







I-477
m.p. 200–202° C.



1HNMR(CDCl3+CD3OD)δ 1.77(s, 3H), 1.81(s, 3H), 3.79(s, 3H),



3.80(s, 3H), 4.64(d, J=6.6Hz, 2H), 5.52–5.57(m, 1H), 6.93(s, 1H),



6.94(s, 1H), 7.03(t, J=9.0Hz, 1H), 7.27–7.30(m, 1H), 7.34–7.41



(m, 3H), 7.52–7.55(m, 2H)



IR(KBr)3600–2800(br), 2404, 1684, 1660, 1584, 1528, 1493,



1462, 1386, 1301, 1274, 1263, 1209, 1132, 1053, 1029cm−1


I-478
m.p. 195–196.5° C.



1HNMR(CDCl3)δ 1.55(s, 9H), 3.78(s, 3H), 3.79(s, 3H), 4.85(s,



1H), 6.75(brs, 1H), 6.88–6.92(m, 2H), 6.92(s, 1H), 6.93(s, 1H),



7.31–7.39(m, 3H), 7.45–7.49(m, 2H), 8.12(t, J=7.5Hz, 1H)



IR(KBr)3600–2800(br), 1729, 1590, 1531, 1500, 1464, 1394,



1261, 1240, 1199, 1156, 1055, 1033, 1023cm−1


I-479
m.p. 172–174° C.



1HNMR(CDCl3)δ 1.55(s, 9H), 3.19(s, 3H), 3.79(s, 3H), 3.80(s,



3H), 6.75(d, J=2.1Hz, 1H), 6.92(s, 1H), 6.94(s, 1H), 7.26–7.39(m,



5H), 7.60–7.65(m, 2H)



IR(KBr)3600–2800(br), 1728, 1590, 1531, 1513, 1494, 1464,



1391, 1367, 1352, 1240, 1206, 1179, 1145, 1056, 1033, 1024cm−1


I-480
m.p. 152–153° C.



1HNMR(CDCl3)δ 1.74(s, 3H), 1.77(s, 3H), 3.18(s, 3H), 3.78(d,



J=9.9Hz, 2H), 3.79(s, 6H), 3.93(brs, 1H), 5.35–5.40(m, 1H), 6.75



(t, J=8.4Hz, 1H), 6.91(s, 1H), 6.95(s, 1H), 7.24–7.36(m, 4H),



7.60–7.65(m, 2H)



IR(KBr)3600–2800(br), 1630, 1530, 1488, 1466, 1380, 1366,



1346, 1259, 1213, 1176, 1149, 1124, 1054, 1027cm−1


I-481
foam



1HNMR(CDCl3)δ 2.40(s, 3H), 3.19(s, 3H), 3.77(s, 3H), 3.78(s,



3H), 6.80(t, d=2.4Hz, 1H), 6.90(s, 1H), 6.91(s, 1H), 7.25–7.36(m,



6H), 7.58–7.65(m, 3H), 7.72–7.76(m, 2H)



IR(KBr)3600–2800(br), 1522, 1490, 1366, 1342, 1211, 1164,



1151, 1091, 1053, 1030cm−1

















TABLE 98







I-482
m.p. 201–203° C.



1HNMR(CDCl3)δ 2.45(s, 3H), 3.20(s, 3H), 3.82(s, 6H), 6.95(s,



1H), 6.98(s, 1H), 7.32–7.48(m, 6H), 7.61–7.66(m, 2H), 7.80–7.84



(m, 2H), 8.10(d, J=3.3Hz, 1H), 8.55(d, J=8.4Hz, 1H)



IR(KBr)3600–2800(br), 1671, 1592, 1524, 1494, 1388, 1366,



1328, 1265, 1207, 1172, 1150, 1052, 1024cm−1


I-483
m.p. 132–134° C.



1HNMR(CDCl3)δ 1.55(s, 9H), 3.00(s, 6H), 3.79(s, 6H), 6.73(d,



J=2.4Hz, 1H), 6.81(m, 2H), 6.92(s, 1H), 6.96(s, 1H), 7.32–7.39



(m, 2H), 7.48–7.52(m, 2H), 8.11(t, J=8.1Hz, 1H)



IR(KBr)3600–2800(br), 1728, 1610, 1591, 1533, 1499, 1459,



1446, 1381, 1365, 1238, 1206, 1159, 1055, 1030cm−1


I-484
foam



1HNMR(CDCl3)δ 1.74(s, 3H), 1.77(s, 3H), 3.00(s, 6H), 3.78(d,



J=9.6Hz, 1H), 3.78(s, 3H), 3.79(s, 3H), 5.34–5.38(m, 1H), 6.75(t,



J=8.4Hz, 1H), 6.92(s, 1H), 6.94(s, 1H), 6.93–6.95(m, 1H), 7.23–



7.32(m, 3H), 7.48–7.52(m, 2H)



IR(KBr)3600–2800(br), 1625, 1611, 1531, 1494, 1446, 1380,



1340, 1257, 1207, 1123, 1055, 1032cm−1


I-485
foam



1HNMR(CDCl3)δ 2.40(s, 3H), 3.00(s, 6H), 3.76(s, 3H), 3.77(s,



3H), 6.70(t, J=2.4Hz, 1H), 6.80(t, J=8.7Hz, 2H), 6.87(s, 1H), 6.94



(s, 1H), 7.24–7.33(m, 4H), 7.46–7.50(m, 2H), 7.60(t, J=9.0Hz,



1H), 7.71–7.75(m, 2H)



IR(KBr)3600–2800(br), 1609, 1529, 1493, 1446, 1381, 1340,



1208, 1164, 1090, 1054, 1031cm−1


I-486
m.p. 184–186° C.



1HNMR(CDCl3)δ 2.45(s, 3H), 3.01(s, 6H), 3.80(s, 3H), 3.81(s,



3H), 6.82(d, J=7.5Hz, 2H), 6.95(s, 1H), 6.98(s, 1H), 7.32(d, J=8.1



Hz, 2H), 7.40–7.52(m, 4H), 7.80–7.84(m, 2H), 8.08(d, J=2.7Hz,



1H), 8.52(t, J=8.4Hz, 1H)



IR(KBr)3600–2800(br), 1647, 1608, 1530, 1497, 1379, 1365,



1284, 1267, 1206, 1051, 1030cm−1

















TABLE 99







I-487
foam



1HNMR(CDCl3)δ 2.36(s, 3H), 3.77(s, 6H), 4.81(brs, 1H), 6.69(dd,



J=0.9, 3.6Hz, 1H), 6.88–6.92(m, 2H), 6.94(s, 1H), 6.95(s, 1H),



7.23–7.26(m, 2H), 7.46–7.51(m, 2H), 7.53(dd, J=1.5, 8.4Hz, 1H),



7.59(d, J=3.6Hz, 1H), 7.73(d, J=0.9Hz, 1H), 7.80–7.84(m, 2H),



8.02(d, J=8.4Hz, 1H)



IR(KBr)3600–2800(br), 1611, 1594, 1520, 1498, 1459, 1444,



1369, 1259, 1208, 1170, 1129, 1092, 1051, 1028cm−1


I-488
m.p. 219–220° C.



1HNMR(CDCl3)δ 2.37(s, 3H), 3.19(s, 3H), 3.78(s, 3H), 3.79(s,



3H), 6.70(dd, J=0.9, 3.6Hz, 1H), 6.94(s, 1H), 6.97(s, 1H), 7.24–



7.27(m, 2H), 7.32–7.37(m, 2H), 7.53(dd, J=1.8, 8.7Hz, 1H), 7.60



(d, J=3.6Hz, 1H), 7.61–7.66(m, 2H), 7.73(d, J=0.9Hz, 1H), 7.80–



7.84(m, 2H), 8.03(d, J=8.7Hz, 1H)



IR(KBr)3600–2800(br), 1513, 1494, 1464, 1444, 1373, 1209,



1173, 1155, 1122, 1049cm−1


I-489
1HNMR(CDCl3)δ 3.79(s, 3H), 3.80(s, 3H), 3.94(s, 3H), 5.17(s,



2H), 5.71(s, 1H), 6.96(s, 1H), 6.97(s, 1H), 6.99(d, J=8.7Hz, 1H),



7.09(d.d, J=8.7&2.4Hz, 1H), 7.22(d, J=2.4Hz), 7.26(s, 1H), 7.32–



7.49(m, 5H), 7.66(d, J=8.7Hz, 2H), 8.09(d, J=8.7Hz, 2H)



IR(KBr)3383, 1702, 1606, 1489, 1381, 1291, 1206, 1111, 1032,



1002cm−1


I-490
1HNMR(CDCl3)δ 3.12(s, 3H), 3.79(s, 3H), 3.81(s, 3H), 395(s,



3H), 5.18(s, 2H), 6.96(s, 2H), 7.12(d, J=8.4Hz, 1H), 7.31–7.53(m,



6H), 7.60(d, J=2.1Hz, 1H), 7.65(d, J=8.7Hz, 2H), 8.10(d, J=8.7Hz,



2H)



IR(KBr)1720, 1607, 1492, 1362, 1275, 1211, 1112, 1057,



1032cm−1


I-491
1HNMR(CDCl3)δ 3.12(s, 3H), 3.80(s, 3H), 3.81(s, 3H), 5.18(s,



2H), 6.92(s, 1H), 6.96(s, 1H), 7.13(d, J=8.4Hz, 1H), 7.31–7.52(m,



6H), 7.70(d, J=2.1Hz, 1H), 7.66–7.77(m, 4H)



IR(KBr)3433, 1685, 1606, 1509, 1492, 1372, 1318, 1264, 1211,



1183, 1111, 1055, 1031cm−1


I-492
1HNMR(CDCl3)δ 3.79(s, 3H), 3.80(s, 3H), 5.17(s, 2H), 5.71(s,



2H), 6.91(s, 1H), 6.97(s, 1H), 7.00(d, J=8.4Hz, 1H), 7.08(dd, J=



8.4&2.4Hz, 1H), 7.22(d, J=2.4Hz, 1H), 7.32–7.49(m, 5H), 7.70(s,



4H)



IR(KBr)3291, 2242, 1607, 1579, 1488, 1384, 1324, 1272, 1209,



1130, 1054, 1034, 1001cm−1

















TABLE 100







I-493
1HNMR(CDCl3)δ 3.12(s, 3H), 3.80(s, 3H), 3.81(s, 3H), 5.18(s,



2H), 6.92(s, 1H), 6.96(s, 1H), 7.12(d, J=8.4Hz, 1H), 7.31–7.72



(m, 6H), 7.60(d, J=1.8Hz, 1H), 7.65–7.74(m, 4H)



IR(KBr)2223, 1604, 1490, 1363, 1296, 1264, 1213, 1172, 1117,



1055, 1036, 1026 cm−1


I-494
1HNMR(CDCl3)δ 1.77(s, 3H), 1.81(s, 3H), 3.23(s, 3H), 3.80(s,



3H), 3.81(s, 3H), 3.95(s, 3H), 4.64(d, J=6.6Hz, 2H), 5.51(t, J=



6.6Hz, 1H), 6.96(s, 2H), 7.06(d, J=8.7Hz, 1H), 7.50(d.d, J=



8.7&2.1Hz, 1H), 7.59(d, J=2.1Hz, 7.65(d, J=8.7Hz, 2H), 8.10



(d, J=8.7Hz, 2H)



IR(KBr)1720, 1608, 1508, 1492, 1384, 1357, 1273, 1179, 1110,



1026, 1019 cm−1


I-495
1HNMR(CDCl3)67  2.38(s, 3H), 3.12(s, 3H), 3.80(s, 6H),



3.81(s, 3H), 3.95(s, 3H), 5.14(s, 2H), 6.96(s, 2H), 7.13(d,



J=8.4Hz, 1H), 7.21(d, J=7.8Hz, 2H), 7.35(d, J=7.8Hz, 2H),



7.49(d.d, J=8.4&1.8Hz, 1H), 7.60(d, J=1.8Hz, 1H), 7.65(d,



J=8.7Hz, 2H), 8.10(d, J=8.7Hz, 2H)



IR(KBr)1697, 1607, 1492, 1364, 1286, 1263, 1213, 1178,



11115, 1057, 1030 cm−1


I-496
IR(KBr)1730, 1701, 1610, 1515, 1465, 1359, 1238, 1186,



1116, 1082, 1064, 1016 cm−1


I-497
1HNMR(CDCl3)δ 1.75(s, 3H), 1.80(s, 3H), 2.89(s, 6H), 3.21(s,



3H), 3.44(s, 3H), 3.68(s, 3H), 3,77(s, 1H), 4.61(d, J=8.4Hz,



2H), 5.49(t, J=8.4Hz, 1H), 6.92(s, 1H), 7.01(d, J=8.4Hz,



1H), 7.25–7.28(m, 3H), 7.33(d, J=2.1Hz, 1H), 7.52(dd,



J=8.4&1.8Hz, 1H), 7.66(d, J=2.4Hz, 1H)



IR(KBr)1727, 1598, 1515, 1467, 1360, 1295, 1258, 1241,



1116, 1084 cm−1


I-498
1HNMR(CDCl3)δ 2.38(s, 3H), 2.89(s, 6H), 3.10(s, 3H), 3.44(s,



3H), 3.66(s, 3H), 3.77(s, 3H), 5.11(s, 3H), 6.93(s, 1H),



7.06–7.15(m, 2H), 7.17–7.29(m, 4H), 7.31–7.37(m, 3H),



7.53(d.d, J=8.7&1.8Hz, 1H), 7.66(d, J=1.8Hz, 1H)



IR(KBr)1732, 1701, 1598, 1518, 1466, 1352, 1294, 1121,



1085, 1060, 1015 cm−1


I-499
1HNMR(CDCl3)δ 2.88(s, 6H), 3.44(s, 3H), 3.64(s, 3H), 3.77(s,



3H), 5.17(s, 2H), 5.65(s, 1H), 6.84(dd, J=8.1&2.1Hz, 1H),



6.92(s, 1H), 6.95(d, J=8.1Hz, 1H), 7.01(d,J=2.1Hz, 1H),



7.12(d, J=8.4Hz, 1H), 7.31–7.46(m, 6H), 7.53(d.d, J=8.4&



1.8Hz, 1H), 7.66(d, J=1.8Hz, 1H)



IR(KBr)3526, 3434, 1732, 1598, 1515, 1460, 1344, 1260,



1240, 1222, 1061, 1013 cm−1

















TABLE 101







I-500
1HNMR(CDCl3)δ 2.60(s, 3H), 3.43(s, 3H), 3.72(s,



3H), 3.75(s, 3H), 5.17(s, 2H), 5.67(s, 1H), 6.77(s, 1H),



6.94(dd, J=8.4&1.8Hz, 1H), 7.02(d, J=8.4Hz, 1H),



7.06(d, J=1.8Hz, 1H), 7.32–7.50(m, 7H), 7.53–7.62(m,



1H), 7.94(d, J=7.8Hz, 1H)



IR(KBr)1732, 1719, 1585, 1521, 1481, 1403, 1352, 1289,



1253, 1225, 1172, 1073, 1012 cm−1


I-501
1HNMR(CDCl3)δ 2.73(s, 3H), 3.12(s, 3H), 3.43(s, 3H),



3.72(s, 3H), 3.76(s, 3H), 5.19(s, 2H), 6.78(s, 1H), 7.15(d,



J=8.4Hz, 1H), 7.31–7.63(m, 10H), 9.96(d, J=6.6Hz, 1H)



IR(KBr)1726, 1609, 1520, 1480, 1400, 1371, 1294, 1262,



1179, 1075, 1009 cm−1


I-502
1HNMR(CDCl3)δ 1.78(s, 3H), 1.81(s, 3H), 3.22(s, 3H),



3.48(s, 3H), 3.71(s, 3H), 3.77(s, 3H), 3.82(s, 3H), 4.66(d,



J=6.9Hz, 2H), 5.56(t, J=6.9Hz, 1H), 6.62(s, 1H), 6.70(s,



1H), 7.11(s, 1H), 7.38(d, J=8.7Hz, 1H), 7.69(d, J=8.7Hz, 1H)



IR(KBr)1699, 1607, 1587, 1516, 1468, 1354, 1216, 1152,



1067, 1044, 1004 cm−1


I-503
1HNMR(CDCl3)δ 1.78(s, 3H), 1.81(s, 3H), 3.21(s, 3H),



3.48(s, 3H), 3.72(s, 3H), 3.74(s, 3H), 3.82(s, 3H), 4.33(d,



J=11.7Hz, 1H), 4.54(d, J=11.7Hz, 1H), 4.65(d, J=8.4Hz,



1H), 5.57(t, J=8.4Hz, 1H), 6.68(s, 1H), 6.69(s, 1H), 6.89



(s, 1H), 7.38(d, J=8.7Hz, 2H), 7.73(d, J=8.7Hz, 2H)



IR(KBr)3530, 1609, 1515, 1467, 1356, 1214, 1174, 1151,



1075, 1039, 1004 cm−1


I-504
1HNMR(CDCl3)δ 1.77(s, 3H), 1.80(s, 3H), 3.22(s, 3H),



3.45(s, 3H), 3.75(s, 3H), 3.77(s, 3H), 3.81(s, 3H), 4.62(d,



J=6.9Hz, 2H), 5.55(t, J=6.9Hz, 1H), 6.64(s, 1H), 6.77(s,



1H), 6.97(s, 1H), 7.39(d, J=8.7Hz, 2H), 7.72(d, J=8.7Hz,



2H)



IR(KBr)3431, 1735, 1706, 1609, 1514, 1474, 1367, 1206,



1176, 1150, 1055, 1039 cm−1


I-505
1HNMR(CDCl3)δ 1.77(s, 3H), 1.80(s, 3H), 2.94(broad, 1H),



3.47(s, 3H), 3.72(s, 3H), 3.73(s, 3H), 3.81(s, 3H), 4.32(s,



1H), 4.36(s, 1H), 4.65(d, J=6.6Hz, 2H), 5.34(s, 1H), 5.57(t,



J=6.6Hz, 1H), 6.69(s, 1H), 6.70(s, 1H), 6.89(s, 1H),



6.91(d, J=8.1Hz, 2H), 7.55(d, J=8.1Hz, 2H)



IR(KBr)3466, 1610, 1517, 1475, 1463, 1386, 1265, 1215,



1170, 1147, 1075, 1042, 1007 cm−1


I-506
1HNMR(CDCl3)δ 1.76(s, 3H), 1.79(s, 3H), 3.44(s, 3H), 3.74(s,



3H), 3.76(s, 3H), 3.80(s, 3H), 4.63(d, J=7.2Hz, 2H), 5.30



(s, 1H), 5.49–5.60(m, 1H), 6.63(s, 1H), 6.78(s, 1H), 6.94(d,



J=8.7Hz, 2H), 6.97(s, 1H), 7.54(d, J=8.7Hz, 2H)



IR(KBr)3382, 1726, 1699, 1611, 1519, 1470, 1206, 1174,



1143, 1074, 1056, 997 cm−1

















TABLE 102







I-507
1HNMR(CDCl3)δ 1.77(s, 3H), 1.79(s, 3H), 3.41(s, 3H), 3.60(s,



3H), 3.74(s, 3H), 3.77(s, 3H), 3.81(s, 3H), 4.63(d, J=



6.9Hz, 2H), 4.74–5.02(broad, 1H), 5.52–5.60(m, 1H), 6.63(s,



1H), 6.75(s, 1H), 6.91(d, J=8.7Hz, 2H), 6.94(s, 1H), 7.54



(d, J=8.7Hz, 2H)



IR(KBr)3423, 1734, 1612, 1520, 1475, 1441, 1395, 1337,



1267, 1215, 1173, 1140, 1017 cm−1


I-508
1HNMR(CDCl3)δ 3.21(s, 3H), 3.45(s, 3H), 3.73(s, 3H),



4.41–4.62(m, 2H), 5.16(s, 2H), 5.71(s, 1H), 6.79(d.d,



J=8.1&2.1Hz, 1H), 6.84(s, 1H), 6.92(d, J=2.1Hz, 1H),



7.01(d, J=8.1Hz, 1H), 7.32–7.50(m, 7H), 7.71(d, J=



8.4Hz, 2H)



IR(KBr)3496, 3255, 1607, 1590, 1528, 1473, 1464, 1358,



1247, 1147, 1071, 1017 cm−1


I-509
1HNMR(CDCl3)δ 3.21(s, 3H), 3.45(s, 3H), 3.73(s, 3H), 3.89(s,



3H), 4.51(d, J=6.3Hz 2H), 5.20(s, 2H), 6.80(d.d, J=



8.1&2.1Hz, 1H), 6.85(s, 1H), 6.89(d, J=2.1Hz, 1H), 6.97(d,



J=8.1Hz, 1H), 7.29–7.51(m, 7H), 7.71(d, J=8.7Hz, 2H)



IR(KBr)3412, 1603, 1586, 1515, 1464, 1364, 1242, 1175,



1151, 1081, 1020, 1006 cm−1


I-510
1HNMR(CDCl3)δ 1.76(s, 3H), 1.80(s, 3H), 3.22(s, 3H), 3.45(s,



3H), 3.73(s, 3H), 3.87(s, 3H), 4.52(s, 2H), 4.64(d, J=



6.6Hz, 2H), 5.57(t, J=6.6Hz, 1H), 6.83(dd, J=7.5&1.2Hz,



1H), 6.86(d, J=1.2Hz, 1H), 6.96(d, J=7.5Hz, 1H)



IR(KBr)3433, 1598, 1579, 1517, 1469, 1372, 1244, 1221,



1174, 1149, 1072, 1017 cm−1


I-511
1HNMR(CDCl3)δ 2.36(s, 3H), 3.21(s, 3H), 3.45(s, 3H), 3.72(s,



3H), 3.88(s, 3H), 4.50(s, 2H), 5.16(s, 2H), 6.80(dd, J=



8.1&2.1Hz, 1H), 6.85(s, 1H), 6.88(d, J=2.1Hz, 1H), 6.97(d,



J=8.1Hz, 1H), 7.20(d, J=8.4Hz, 2H), 7.33–7.42(m,



4H), 7.71(d, J=8.4Hz, 2H)



IR(KBr)3502, 1604, 1510, 1465, 1383, 1360, 1266, 1239,



1227, 1147, 1071, 1008 cm−1


I-512
1HNMR(CDCl3)δ 3.45(s, 3H), 3.72(s, 3H), 3.89(s, 3H), 4.48(s,



2H), 5.20(s, 2H), 6.18(dd, J=8.1&2.1Hz, 1H) 6.86(s,



1H), 6.88–6.99(m, 4H), 7.27–7.43(m, 3H), 7.46–7.54



(m, 4H)



IR(KBr)3528, 1610, 1591, 1517, 1474, 1461, 1438, 1388,



1263, 1239, 1173, 1140, 1017 cm−1


I-513
1HNMR(CDCl3)δ 1.75(s, 3H), 1.79(s, 3H), 2.47(broads, 1H),



3.45(s, 3H), 3.73(s, 3H), 3.86(s, 3H), 4.52(s, 2H), 4.63(d,



J=6.6Hz, 2H), 5.16(s, 1H), 5.56(d, J=6.6Hz, 1H),



6.82–6.97(m, 6H), 7.53(d, J=9.0Hz, 2H)



IR(KBr)3477, 3246, 1609, 1586, 1518, 1464, 1439, 1387,



1266, 1240, 1221, 1173, 1141, 1079, 1011, 1002 cm−1

















TABLE 103







I-514
1HNMR(CDCl3)δ 2.36(s, 3H), 2.48(broad, 1H), 3.44(s, 3H), 3.72



(s, 3H), 3.88(s, 3H), 4.50(s, 2H), 5.16(s, 3H), 6.76–6.98(m, 6H),



7.19(d, J=7.8Hz, 2H), 7.36(d, J=7.8Hz, 2H), 7.52(d, J=8.7Hz, 2H)



IR(KBr)3544, 3239, 1614, 1593, 1519, 1463, 1386, 1266, 1240,



1218, 1173, 1139, 1074, 1010cm−1


I-515
m.p. 159–160° C.



1HNMR(CDCl3)δ 3.19(s, 3H), 3.34(s, 3H), 3.79(s, 3H), 3.80(s,



3H), 5.18(ABq, J=12.3Hz, 2H), 6.92(s, 1H), 6.93(s, 1H), 7.08(d,



J=8.7Hz, 1H), 7.33–7..64(m, 11H)



IR(KBr)3433, 2937, 1694, 1520, 1492, 1369, 1288, 1243, 1211,



1176, 1150, 1100cm−1


I-516
1HNMR(CDCl3)δ 2.91(s, 3H), 3.777(s, 3H), 3.783(s, 3H), 4.85



(brs, 1H), 5.12(s, 2H), 6.87–7.00(m, 7H), 7.32–7.50(m, 7H)



IR(KBr)3432, 2938, 1609, 1590, 1525, 1494, 1380, 1254, 1207,



1174, 1152, 1058, 1031cm−1


I-517
m.p. 213–215° C.



1HNMR(CDCl3)δ 2.99(s, 3H), 3.779(s, 3H), 3.804(s, 3H), 4.86



(brs, 1H), 5.16(s, 2H), 6.83(brs, 1H), 6.93(s, 1H), 6.94(s, 1H),



7.06(d, J=8.7Hz, 1H), 7.35(dd, J=2.1, 8.7Hz, 1H), 7.41–7.49(m,



7H), 7.81(d, J=2.1Hz, 1H)



IR(KBr)3409, 3374, 1610, 1525, 1491, 1371, 1321, 1251, 1208,



1145, 1120, 1037cm−1


I-518
powder



1HNMR(CDCl3)δ 1.75(s, 3H), 1.81(s, 3H), 2.84(s, 3H), 3.21(s,



3H), 3.22(s, 3H), 3.55(s, 3H), 3.79(s, 3H), 3.93(s, 3H), 4.67(d,



J=7.2Hz, 2H), 5.59(m, 1H), 6.85(s, 1H), 7.36–7.42(m, 2H), 7.62



(d, J=2.1Hz, 1H), 7.65–7.70(m, 2H), 7.86(d, J=2.1Hz, 1H)



IR(CHCl3)3026, 2940, 1728, 1510, 1473, 1373, 1179, 1150,



1086cm−1


I-519
powder



1HNMR(CDCl3)δ 1.69(s, 3H), 1.74(s, 3H), 2.52–2.61(m, 2H),



2.86(s, 3H), 3.20(s, 3H), 3.21(s, 3H), 3.55(s, 3H), 3.79(s, 3H),



3.93(s, 3H), 4.21(t, J=6.9Hz, 2H), 5.26(m, 1H), 6.86(s, 1H),



7.36–7.42(m, 2H), 7.62(d, J=2.1Hz, 1H), 7.65–7.70(m, 2H), 7.86



(d, J=2.1Hz, 1H)



IR(CHCl3)3024, 2939, 1729, 1511, 1475, 1447, 1373, 1179, 1150,



1085cm−1

















TABLE 104







I-520
powder



1HNMR(CDCl3)δ 2.84(s, 3H), 3.21(s, 3H), 3.22(s, 3H), 3.56(s,



3H), 3.81(s, 3H), 3.88(s, 3H), 5.30(s, 2H), 6.86(s, 1H), 7.26–7.32



(m, 1H), 7.37–7.42(m, 2H), 7.65–7.72(m, 4H), 7.76–7.83(m, 1H),



7.92(d, J=2.1Hz, 1H), 8.60–8.63(m, 1H)



IR(KBr)3434, 3019, 2940, 1730, 1511, 1474, 1367, 1178, 1151,



1082cm−1


I-521
powder



1HNMR(CDCl3+CD3OD)δ 1.69(s, 3H), 1.77(s, 3H), 2.51–2.58(m,



2H), 3.43(s, 3H), 3.73(s, 3H), 4.23(t, J=6.6Hz, 2H), 6.44(s, 1H),



6.89–6.95(m, 2H), 7.24(d, J=1.8Hz, 1H), 7.46–7.52(m, 2H), 7.65–



7.67(m, 1H)



IR(KBr)3434, 2934, 1716, 1611, 1402, 1226, 1116, 1082,



1027cm−1


I-522
m.p. 240–243° C.



1HNMR(CDCl3+CD3OD)δ 3.44(s, 3H), 3.75(s, 3H), 5.31(s, 2H),



6.46(s, 1H), 6.89–6.95(m, 2H), 7.30–7.31(m, 1H), 7.35–7.42(m,



2H), 7.47–7.53(m, 2H), 7.56(d, J=2.4Hz, 1H), 7.79–7.86(m, 1H),



8.65–8.68(m, 1H)



IR(KBr)3411, 2937, 1683, 1611, 1521, 1406, 1230, 1115, 1082,



1026cm−1


I-523
m.p. 136–137° C.



1HNMR(CDCl3)δ 2.25(s, 3H), 2.29(s, 3H), 3.12(s, 3H), 3.20(s,



3H), 5.18(s, 2H), 7.11(s, 1H), 7.14(s, 1H), 7.23–7.51(m, 12H)



IR(KBr)1518, 1488, 1357, 1263, 1170, 1150, 1110, 970, 873, 848,



809cm−1


I-524
m.p. 121–122° C.



1HNMR(CDCl3)δ 1.77(s, 3H), 1.82(s, 3H), 2.25(s, 3H), 2.29(s,



3H), 3.20(s, 3H), 3.23(s, 3H), 4.64(d, J=6.6Hz, 2H), 5.52(t, J=6.6



Hz, 1H), 7.06(d, J=8.4Hz, 1H), 7.11(s, 1H), 7.14(s, 1H), 7.24(d,



J=2.1Hz, 1H), 7.31–7.45(m, 5H)



IR(KBr)1518, 1487, 1363, 1170, 1150, 1108, 970, 869, 848,



808cm−1


I-525
m.p. 149–151° C.



1HNMR(CDCl3)δ 1.77(s, 3H), 1.83(d, J=0.6Hz, 3H), 2.26(s, 3H),



2.28(s, 3H), 4.62(d, J=6.9Hz, 2H), 4.80(s, 1H), 5.53(m, 1H), 5.72



(s, 1H), 6.82(dd, J=2.1, 8.4Hz, 1H), 6.85–6.94(m, 3H), 6.96(d,



J=2.1Hz, 1H), 7.10(s, 1H), 7.12(s, 1H), 7.21–7.28(m, 2H)



IR(KBr)3521, 3395, 1612, 1584, 1522, 1490, 1457, 1285, 1263,



1242, 1200, 1170, 1125, 1014, 834cm−1

















TABLE 105







I-526
foam



1HNMR(CDCl3)δ 2.43(s, 3H), 2.76(s, 3H), 2.90(s, 3H), 3.22(s,



3H), 3.56(s, 3H), 3.80(s, 3H), 5.30(s, 2H), 6.28(t, J=3.3Hz, 1H),



6.42(dd, J=3.3, 1.6Hz, 1H), 6.85(s, 1H), 7.12, (d, J=8.4Hz, 1H),



7.32(d, J=8.7Hz, 2H), 7.34~7.37(m, 2H), 7.39(d, J=8.7Hz, 2H),



7.40(d, J=1.8Hz, 1H), 7.69(d, J=8.7Hz, 2H), 7.78(d, J=8.7Hz, 2H)



IR(Nujol)1608, 1597, 1519, 1480, 1464, 1176, 1152, 1087, 972,



875, 817, 798cm−1


I-527
foam



1HNMR(CDCl3)δ 2.96(s, 3H), 3.21(s, 3H), 3.37(s, 3H), 3.52(s,



3H), 3.77(s, 3H), 5.58(s, 2H), 6.84(s, 1H), 7.19(d, J=8.4Hz, 1H),



7.24~7.28(m, 4H), 7.31, (dd, J=8.4, 1.8Hz, 1H), 7.33(d, J=1.8Hz,



1H), 7.38(d, J=8.7Hz, 2H), 7.67(d, J=8.7Hz, 2H)



IR(Nujol)1664, 1609, 1519, 1480, 1457, 1176, 1151, 1079, 970,



947, 876, 798, 748cm−1


I-528
foam



1HNMR(CDCl3)δ 2.73(s, 3H), 2.94(s, 3H), 3.21(s, 3H), 3.33(t, J=



6.3Hz, 2H), 3.55(s, 3H), 3.77(s, 3H), 4.55(t, J=6.3Hz, 2H), 6.83(s,



1H), 7.14(d, J=8.1Hz, 1H), 7.18(brdd, J=7.8, 5.1Hz, 1H), 7.33



(brd, J=7.8Hz, 1H), 7.35(dd, J=8.1, 1.8Hz, 1H), 7.37(d, J=1.8Hz,



1H), 7.38(d, J=8.7Hz, 2H), 7.65(m, 1H), 7.67(d, J=8.7Hz, 2H),



8.56(brd, J=5.1Hz, 1H)



IR(Nujol)1608, 1593, 1520, 1479, 1466, 1177, 1151, 1079, 970,



872, 816, 798cm−1


I-529
m.p. 203–205° C.



1HNMR(DMSO-d6)δ 2.42(s, 3H), 2.80(s, 3H), 3.45(s, 3H), 3.51(s,



3H), 3.56(s, 3H), 3.78(s, 3H), 5.36(s, 2H), 7.07(s, 1H), 7.23(s,



1H), 7.26~7.28(m, 3H), 7.48, (d, J=8.7Hz, 2H), 7.74(d, J=8.7Hz,



2H)



IR(Nujol)1599, 1518, 1480, 1466, 1176, 1081, 1013, 976, 870,



830, 797, 755cm−1


I-530
foam



1HNMR(CD3OD)δ 3.38(s, 3H), 3.68(s, 3H), 5.41(s, 2H), 6.44(s,



1H), 6.82(dd, J=8.4, 2.1Hz, 1H), 6.85(d, J=8.7Hz, 2H), 6.93(d,



J=2.1Hz, 1H), 7.06(d, J=8.4Hz, 1H), 7.27(m, 2H), 7.46(d, J=8.7



Hz, 2H), 7.60(m, 2H)



IR(Nujol)3304, 161, 1590, 1522, 1488, 1458, 1254, 1115, 1074,



1046, 1014, 942, 825, 745cm−1

















TABLE 106







I-531
m.p. 159–162° C.



1HNMR(DMSO-d6)δ 2.92(s, 3H), 3.41(s, 3H), 3.45(s, 3H), 3.52



(s, 3H), 3.79(s, 3H), 5.33(s, 2H), 7.09(s, 1H), 6.82~7.45(m,



3H), 7.49(d, J=9.0Hz, 2H), 7.75(d, J=9.0Hz, 2H)



IR(Nujol)1604, 1519, 1481, 1469, 1235, 1171, 1154, 1085,



1012, 967, 874, 849, 798 cm−1


I-532
m.p. 214–216° C.



1HNMR(DMSO-d6)δ 2.84(s, 3H), 3.42(s, 3H), 3.45(s, 3H),



3.52(s, 3H), 3.73(s, 3H), 3.79(s, 3H), 4.99(s, 2H), 7.08(s, 1H),



7.24(dJ=9.3Hz, 1H), 7.29(dd, J=9.3, 1.8Hz, 1H), 7.30(d,



J=1.8Hz, 1H), 7.48(d, J=8.7Hz, 2H), 7.74(d, J=8.7Hz, 2H)



IR(Nujol)1767, 1606, 1521, 1481, 1463, 1216, 1175, 1151,



1080, 1013, 977, 946, 878, 821, 798 cm−1


I-533
m.p. 225–227° C.



1HNMR(DMSO-d6)δ 2.86(s, 3H), 3.45(s, 3H), 3.46(s,



3H), 3.52(s, 3H), 3.78(s, 3H), 4.46(s, 2H), 7.08(s, 1H), 7.20(d,



J=8.4Hz, 1H), 7.28–7.32(m, 2H), 7.48(d, J=8.7Hz, 2H),



7.74(d, J=8.7Hz, 2H)



IR(Nujol)3340, 1677, 1619, 1519, 1477, 1463, 1443, 1176,



1150, 1088, 971, 871, 829, 794 cm−1


I-534
foam



1HNMR(DMSO-d6)δ 2.96(s, 3H), 3.45(s, 3H), 3.47(s,



3H), 3.52(s, 3H), 3.79(s, 3H), 4.64(s, 2H), 7.08(s, 1H), 7.18(d,



J=8.4Hz, 1H), 7.31(dd, J=8.4, 1.8Hz, 1H), 7.34(d, J=1.8Hz,



1H), 7.48(d, J=8.7Hz, 2H), 7.74(d, J=8.7Hz, 2H)



IR(Nujol)3464, 3362, 1693, 1606, 1520, 1481, 1176, 1151,



1080, 876, 822, 799 cm−1


I-535
m.p. 163–165° C.



1HNMR(CDCl3)δ 2.73(s, 3H), 3.16(s, 3H), 3.21(s, 3H),



3.55(s, 3H), 3.78(s, 3H), 4.85(ddd, J=1.5, 1.5, 5.4Hz, 2H), 5.25



(s, 2H), 5.31, (ddd, J=1.5, 3.0, 10.5Hz, 1H), 5.43(ddd, J=1.5,



3.0, 17.1Hz, 1H), 6.05(ddd, J=5.4, 10.5, 17.1Hz, 1H), 6.84(s,



1H), 7.11(d, J=8.7Hz, 1H), 7.34(dd, J=2.1, 8.7Hz, 1H), 7.38(d,



J=8.4Hz, 2H), 7.41(d, J=2.1Hz, 1H), 7.56(d, J=8.4Hz, 2H),



7.67(d, J=8.4Hz, 2H), 8.11(d, J=8.4Hz, 2H)



IR(KBr)1718, 1612, 1519, 1481, 1365, 1273, 1177, 1151,



1119, 1080, 1015, 969, 876 cm−1

















TABLE 107







I-536
m.p. 115–117° C.



1HNMR(CDCl3)δ 2.68(s, 3H), 3.13(s, 3H), 3.21(s, 3H), 3.55(s,



3H), 3.68(s, 2H), 3.78(s, 3H), 4.61(ddd, J=1.5, 1.5, 5.7Hz, 2H),



5.17(s, 2H), 5.23, (ddd, J=1.5, 3.0, 10.5,Hz, 1H), 5.28(ddd,



J=1.5, 3.0, 16.8Hz, 1H), 5.91(ddd, J=5.7, 10.5, 16.8Hz,



1H), 6.84(s, 1H), 7.13(d, J=8.4Hz, 1H), 7.33(d, J=8.1Hz, 2H),



7.34(dd, J=2.1, 8.4Hz, 1H), 7.38(d, J=8.4Hz, 2H), 7.40(d,



J=2.1Hz, 1H), 7.42(d, J=8.1Hz, 2H), 7.68(d, J=8.4Hz, 2H)



IR(KBr)1734, 1609, 1520, 1481, 1365, 1236, 1177, 1151,



1119, 1079, 970, 876, 797 cm−1


I-537
m.p. 227–229° C.



1HNMR(CDCl3)δ 2.73(s, 3H), 3.16(s, 3H), 3.21(s, 3H),



3.54(s, 3H), 3.77(s, 3H), 5.26(s, 2H), 6.83(s, 1H), 7.11(d,



J=12.3Hz, 2H), 7.32(s, 1H), 7.37(d, J=12.3Hz, 2H), 7.41(s, 1H),



7.57(d, J=12.3Hz, 1H), 7.66(d, J=12.3Hz, 2H), 8.13(d,



J=12.3Hz, 2H)



IR(KBr)3430, 1694, 1612, 1519, 1481, 1365, 1177, 1151,



1079, 875, 798 cm−1


I-538
m.p. 149–151° C.



1HNMR(CDCl3)δ 2.66(s, 3H), 3.13(s, 3H), 3.21(s, 3H), 3.55(s,



3H), 3.68(s, 2H), 3.77(s, 3H), 5.17(s, 2H), 6.84(s, 1H), 7.13(d,



J=8.4Hz, 1H), 7.30–7.55(m, 4H), 7.38(d, J=8.4Hz, 2H),



7.67(d, J=8.4Hz, 2H), 7.67(m, 2H)



IR(KBr)3423, 1716, 1610, 1519, 1481, 1365, 1235, 1177,



1151, 1119, 1080, 876, 798 cm−1


I-539
m.p. 144–146° C.



1HNMR(CDCl3)δ 2.32(s, 3H), 2.69(s, 3H), 3.14(s, 3H), 3.21(s,



3H), 3.56(s, 3H), 3.78(s, 3H), 5.18(s, 2H), 6.84(s, 1H), 7.14(d,



J=8.7Hz, 2H), 7.15(d, J=8.4Hz, 1H), 7.34(dd, J=2.1, 8.4Hz,



1H), 7.38(d, J=8.4Hz, 2H), 7.40(d, J=2.1Hz, 1H), 7.48(d,



J=8.7Hz, 2H), 7.67(d, J=8.4Hz, 2H)



IR(KBr)1760, 1519, 1481, 1365, 1177, 1151, 1119, 1079,



876, 797 cm−1


I-540
m.p. 228–231° C.



1HNMR(CDCl3)δ 2.81(s, 3H), 3.20(s, 3H), 3.21(s, 3H), 3.55(s,



3H), 3.78(s, 3H), 5.30(s, 2H), 6.85(s, 1H), 7.11(d, J=8.4Hz,



1H), 7.35(dd, J=2.1, 8.4Hz, 1H), 7.39(d, J=8.4Hz, 2H),



7.41(d, J=2.1Hz, 1H), 7.67(d, J=8.4Hz, 2H), 7.69(d,



J=8.7Hz, 2H), 8.28(d, J=8.7Hz, 2H)



IR(KBr)1608, 1521, 1481, 1361, 1179, 1148, 1080,



880, 799 cm−1

















TABLE 108







I-541
m.p. 153–156° C.



1HNMR(CDCl3)δ 1.53(s, 9H), 2.69(s, 3H), 3.15(s, 3H),



3.21(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 5.19(s, 2H), 6.84(s, 1H),



7.10(dd, J=7.5, 7.5Hz, 1H), 7.17(d, J=7.5Hz, 1H), 7.23(d,



J=8.4Hz, 1H), 7.26(dd, J=7.5, 7.5Hz, 1H), 7.33(d,



J=7.5Hz, 1H), 7.37(dd, J=2.1, 8.4Hz, 1H), 7.38(d,



J=8.4Hz, 2H), 7.40(d, J=2.1Hz, 1H), 7.67(d,



J=8.4Hz, 2H)



IR(KBr)3405, 1724, 1519, 1480, 1366, 1236, 1177, 1153,



1080, 970, 875, 798 cm−1


I-542
m.p. 178–182° C.



1HNMR(CDCl3)δ 2.70(s, 3H), 3.15(s, 3H), 3.21(s, 3H), 3.55(s,



3H), 3.78(s, 3H), 5.14(s, 2H), 6.76(m, 2H), 6.84(s, 1H), 7.19(m,



2H), 7.26(d, J=8.7Hz, 1H), 7.37(d, J=2.7Hz, 1H), 7.36(dd,



J=2.7, 8.7Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.68(d,



J=8.7Hz, 2H)



IR(KBr)3448, 1627, 1608, 1519, 1497, 1364, 1177, 1151,



1079, 971, 876, 798 cm−1


I-543
m.p. 187–189° C.



1HNMR(CDCl3)δ 2.38(s, 3H), 3.39(s, 3H), 3.45(s, 3H),



5.11–5.14(m, 3H), 5.89(s, 1H), 6.33(s, 1H), 6.88–6.94(m,



2H), 7.20–7.36(m, 6H), 7.43(d, J=2.1Hz, 1H), 7.76(d,



J=0.6Hz, 1H)



IR(KBr)3414, 2942, 1613, 1534, 1469, 1355, 1266, 1172,



1092, 1030 cm−1


I-544
m.p. 207–215° C.(dec.)



1HNMR(d6-DMSO)δ 2.37(s, 3H), 3.67(brs, 2H), 4.56(brs, 2H),



4.90(s, 2H), 6.14–6.20(m, 2H), 6.86(d, J=8.7Hz, 2H), 7.11–



7.22(m, 4H), 7.42(d, J=8.7Hz, 2H), 7.52(s, 1H), 8.94(s, 1H),



9.47(s, 1H)



IR(KBr)3388, 3301, 2932, 1612, 1591, 1521, 1458, 1413,



1288, 1030 cm−1


I-545
m.p. 108–110° C.



1HNMR(CDCl3)δ 1.69(s, 3H), 1.74(s, 3H), 2.49–2.59(m,



2H), 3.03(s, 3H), 3.20(s, 3H), 3.56(s, 3H), 3.75(s, 3H), 4.06(t,



J=6.6Hz, 2H), 4.93(s, 2H), 5.22(m, 1H), 6.66(s, 1H), 7.04(d,



J=8.7Hz, 1H), 7.09–7.17(m, 2H), 7.37(dd, J=2.1, 8.7Hz,



1H), 7.44(d, J=2.1Hz, 1H), 7.51–7.58(m, 2H)



IR(KBr)3434, 2933, 1604, 1521, 1473, 1383, 1360, 1278,



1160, 1121, 1084, 1017 cm−1

















TABLE 109







I-546
m.p. 109–110° C.



1HNMR(CDCl3)δ 1.69(s, 3H), 1.75(s, 3H), 248–2.58(m, 2H),



4.07(t, J=6.6Hz, 2H), 5.22(m, 1H), 5.69(s, 1H),



5.87(s, 1H), 6.44(s, 1H),



6.93–6.95(m, 2H), 7.04–7.06(m, 1H), 7.10–7.18(m, 2H),



7.58–7.64(m, 2H)



IR(KBr)3411, 2932, 1608, 1587, 1522, 1491, 1226, 1111,



1074, 1017 cm−1


I-547
m.p. 141–142° C.



1HNMR(CDCl3)δ 3.03(s, 3H), 3.57(s, 3H), 3.75(s, 3H), 4.90(s,



2H), 5.16(s, 2H), 5.65(brs, 1H), 6.66(s, 1H), 6.92(dd, J=1.8,



8.4Hz, 1H), 6.99(d, J=8.4Hz, 1H), 7.06(d, J=1.8Hz, 1H),



7.10–7.17(m, 2H), 7.35–7.47(m, 5H), 7.52–7.59(m, 2H)



IR(KBr)3529, 3439, 2932, 1601, 1518, 1477, 1461, 1380,



1251, 1224, 1157, 1113, 1094, 1076 cm−1


I-548
m.p. 133–136° C.



1HNMR(CDCl3)δ 2.98(s, 3H), 3.12(s, 3H), 3.56(s, 3H),



3.75(s, 3H), 4.94(s, 2H), 5.18(s, 2H), 6.67(s, 1H), 7.09–7.17(m,



3H), 7.34–7.49(m, 7H), 7.51–7.58(m, 2H)



IR(KBr)3434, 2941, 1598, 1519, 1481, 1383, 1365, 1279,



1231, 1164, 1099, 1081 cm−1


I-549
m.p. 161–162° C.



1HNMR(CDCl3)δ 3.10(s, 3H), 3.42(s, 3H), 3.76(s, 3H), 5.17(s,



2H), 6.05(s, 1H), 6.44(s, 1H), 7.11–7.20(m, 3H), 7.33–7.50(m,



7H), 7.52(d, J=2.1Hz, 1H), 7.57–7.65(m, 2H)



IR(KBr)3488, 2938, 1613, 1523, 1486, 1290, 1223, 1107,



1071, 1012 cm−1


I-550
m.p. 113–115° C.



1HNMR(CDCl3)δ 2.37(s, 3H), 2.98(s, 3H), 3.11(s, 3H), 3.56(s,



3H), 3.75(s, 3H), 4.93(s, 2H), 5.13(s, 2H), 6.66(s, 1H),



7.09–7.17(m, 3H), 7.18–7.23(m, 2H), 7.32–7.39(m, 3H),



7.45(d, J=1.8Hz, 1H), 7.51–7.58(m, 2H)



IR(KBr)3434, 2934, 1738, 1601, 1520, 1478, 1466, 1376,



1356, 1236, 1159, 1109, 1070, 1014 cm−1

















TABLE 110







I-551
m.p. 138–140° C.



1HNMR(CDCl3)δ 2.38(s, 3H), 3.04(s, 3H), 3.57(s, 3H), 3.74(s,



3H), 4.90(s, 2H), 5.11(s, 2H), 5.63(s, 1H), 6.66(s, 1H), 6.91(dd,



J=2.1, 8.4Hz, 1H), 6.99(d, J=8.4Hz, 1H), 7.05(d, J=1.8Hz,



1H), 7.08–7.17(m, 2H), 7.22(d, J=7.8Hz, 2H), 7.33(d, J=



7.8Hz, 2H), 7.52–7.59(m, 2H)



IR(KBr)3446, 2934, 1601, 1518, 1476, 1461, 1379, 1252,



1224, 1158, 1092, 1011 cm−1


I-552
m.p. 188–190° C.



1HNMR(CDCl3)δ 2.38(s, 3H), 3.10(s, 3H), 3.42(s, 3H), 3.75(s,



3H), 5.12(s, 2H), 6.04(s, 1H), 6.43(s, 1H), 7.11–7.25(m, 5H),



7.35(d, J=7.8Hz, 2H), 7.42(dd, J=2.4, 8.7Hz, 1H), 7.51(d,



J=2.4Hz, 1H), 7.57–7.65(m, 2H)



IR(KBr)3433, 2963, 1611, 1523, 1485, 1355, 1282, 1226,



1163, 1106, 1071 cm−1


I-553
m.p. 149–150° C.



1HNMR(CDCl3)δ 3.13(s, 3H), 3.21(s, 3H), 5.20(s, 2H),



7.17(d, J=8.4Hz, 1H), 7.24(m, 1H), 7.36–7.54(m, 9H),



7.58(dd, J=1.2, 2.4Hz, 1H), 7.60–7.67(m, 2H)



IR(KBr)1524, 1485, 1354, 1292, 1263, 1181, 1150, 1114,



977, 869, 858, 850, 812, 796 cm−1


I-554
m.p. 92–93° C.



1HNMR(CDCl3)δ 1.69(s, 3H), 1.74(d, J=1.2Hz, 3H), 2.25(s,



3H), 2.28(s, 3H), 2.56(dt, J=6.6, 7.2Hz, 2H), 3.20(s, 3H),



3.21(s, 3H), 4.07(t, J=7.2Hz, 2H), 5.22(m, 1H), 7.05(d,



J=8.4Hz, 1H), 7.11(s, 1H), 7.13(s, 1H), 7.25(dd, J=2.1,



8.4Hz, 1H), 7.31–7.43(m, 5H)



IR(KBr)1518, 1488, 1355, 1293, 1264, 1169, 1151, 1109,



970, 872, 818 cm−1


I-555
m.p. 126–127° C.



1HNMR(CDCl3)δ 1.77(s, 3H), 1.82(s, 3H), 3.20(s, 3H), 3.23(s,



3H), 4.65(d, J=6.6Hz, 2H), 5.50(m, 1H), 7.10(d, J=8.7Hz,



1H), 7.18–7.27(m, 2H), 7.36–7.43(m, 2H), 7.50(dd, J=1.5,



8.7Hz, 1H), 7.55(d, J=1.5Hz, 1H), 7.60–7.66(m, 2H)



IR(KBr)1527, 1489, 1359, 1295, 1266, 1177, 1153, 1118,



974, 894, 874 cm−1

















TABLE 111







I-556
m.p. 154–155° C.



1HNMR(CDCl3)δ 2.25(s, 3H), 2.28(s, 3H), 2.38(s, 3H), 3.11(s,



3H), 3.20(s, 3H), 5.13(s, 2H), 7.11(s, 1H), 7.14(s, 1H), 7.19–



7.28(m, 4H), 7.31–7.43(m, 7H)



IR(KBr)1520, 1487, 1365, 1284, 1260, 1192, 1172, 1152,



1108, 967, 867, 809, 795 cm−1


I-557
m.p. 112–113° C.



1HNMR(CDCl3)δ 1.69(s, 3H), 1.76(s, 3H), 2.26(s, 3H), 2.27(s,



3H), 2.54(dt, J=7.2, 6.9Hz, 2H), 4.07(t, J=6.9Hz, 2H), 4.86(s,



1H), 5.23(m, 1H), 5.71(s, 1H), 6.82(dd, J=2.1, 8.4Hz, 1H),



6.85–6.93(m, 3H), 6.96(d, J=2.1Hz, 1H), 7.10(s, 1H),



7.12(s, 1H), 7.22–7.27(m, 2H)



IR(KBr)3380, 1613, 1586, 1523, 1490, 1471, 1431, 1391,



1293, 1261, 1246, 1205, 1171, 1130, 836 cm−1


I-558
m.p. 141–142° C.



1HNMR(CDCl3)δ 1.77(s, 3H), 1.82(s, 3H), 4.63(d, J=6.9Hz,



2H), 5.06(s, 1H), 5.52(m, 1H), 5.75(s, 1H), 6.89–6.97(m,



3H), 7.07(dt, J=8.4, 1.8Hz, 1H), 7.14–7.23(m, 3H),



7.44–7.51(m, 2H)



IR(KBr)3429, 1612, 1594, 1531, 1489, 1467, 1449, 1401,



1259, 1213, 1169, 1132, 835, 781 cm−1


I-559
m.p. 179–180° C.



1HNMR(CDCl3)δ 2.26(s, 3H), 2.28(s, 3H), 2.39(s, 3H), 4.81(s,



1H), 5.11(s, 2H), 5.70(s, 1H), 6.83(dd, J=2.1, 8.4Hz,



1H), 6.86–6.91(m, 2H), 6.98(d, J=8.4Hz, 1H), 6.98(d, J=



2.1Hz, 1H), 7.10(s, 1H), 7.12(s, 1H), 7.21–7.28(m, 4H), 7.32–



7.38(m, 2H)



IR(KBr)3317, 1609, 1520, 1489, 1426, 1378, 1247, 1206,



1175, 1124, 1006, 792 cm−1


I-560
foam



1HNMR(DMSO-d6)δ 3.74(s, 3H), 3.75(s, 3H), 4.62(d, J=5.0Hz,



2H), 5.02(t, J=5.0Hz, 1H), 5.19(s, 2H), 6.94(s, 1H), 6.99(s,



1H), 7.06(d, J=8.0Hz, 1H), 7.22(ddd, J=8.6, 2.0, 0.8Hz, 1H),



7.32–7.52(m, 8H), 7.57(d, J=2.4Hz, 1H), 9.91(brs, 1H)



IR(KBr)3257, 1525, 1491, 1464, 1453, 1382, 1207, 1035,



764, 737 cm−1

















TABLE 112







I-561
m.p. 147–148° C.



1HNMR(CDCl3)δ 3.27(s, 3H), 3.79(s, 3H), 3.82(s, 3H), 5.26(s,



2H), 6.92(s, 1H), 6.95(s, 1H), 7.13(d, J=8.7Hz, 1H), 7.35–7.50



(m, 8H), 7.80(dd, J=8.7, 2.7Hz, 1H), 8.05(d, J=2.7Hz, 1H),



10.62(s, 1H)



IR(KBr)1682, 1606, 1489, 1377, 1345, 1261, 1209, 1168,



1119, 1038, 871, 832 cm−1


I-562
m.p. 189–191° C.



1HNMR(DMSO-d6)δ 3.53(s, 3H), 3.80(s, 3H), 3.80(s, 3H), 5.27



(s, 2H), 7.05(s, 1H), 7.10(s, 1H), 7.25(d, J=8.7Hz, 1H), 7.30–



7.59(m, 7H), 7.66(dd, J=11.7, 2.1Hz, 1H), 7.67(dd, J=8.7,



2.3Hz, 1H), 7.84(d, J=2.3Hz, 1H), 12.7(brs, 1H)



IR(KBr)3433, 1705, 1492, 1371, 1250, 1207, 1168,



1033, 868 cm−1


I-563
m.p. 204–207° C.



1HNMR(CDCl3)δ 1.36(s, 9H), 3.20(s, 3H), 3.41(s, 3H), 3.74(s,



3H), 5.15(s, 2H), 5.65(s, 1H), 5.77(s, 1H), 6.80(s, 1H), 6.83(dd,



J=8.4, 2.0Hz, 1H), 6.96(d, J=2.0Hz, 1H), 6.98(d, J=8.4Hz,



1H), 7.34–7.45(m, 7H), 7.68(d, J=8.7Hz, 2H)



IR(KBr)3408, 3337, 1692, 1498, 1474, 1466, 1347, 1251,



1150, 870, 855 cm−1


I-564
m.p. 179–182° C.



1HNMR(DMSO-d6)δ 3.76(s, 3H), 3.76(s, 3H), 5.26(s, 2H), 6.99



(s, 1H), 7.00(t, J=8.7Hz, 1H), 7.01(s, 1H), 7.22(ddd,



J=8.7, 2.4Hz, J=1.2Hz, 1H), 7.24(d, J=8.9Hz, 1H),



7.32–7.54(m, 6H), 7.65(dd, J=8.9, 2.4Hz, 1H), 7.82(d,



J=2.4Hz, 1H), 9.91(s, 1H), 12.6(brs, 1H)



IR(KBr)3422, 3277, 1726, 1526, 1491, 1416, 1396, 1284,



1210, 1031 cm−1


I-565
m.p. 178–180° C.



1HNMR(DMSO-d6)δ 3.30(s, 3H), 3.43(s, 3H), 3.61(s, 3H),



4.31(s, 2H), 5.14(s, 2H), 6.25(s, 1H), 6.61(dd, J=8.4, 1.9Hz,



1H), 7.05(d, J=8.4Hz, 1H), 7.33–7.44(m, 6H), 7.50–7.54(m,



2H), 7.70(d, J=8.7Hz, 2H), 9.08(s, 1H)



IR(KBr)3435, 3378, 1593, 1518, 1481, 1360, 1245, 1147,



1119, 1010, 871 cm−1

















TABLE 113







I-566
foam



1HNMR(DMSO-d6)δ 3.27(s, 3H), 3.59(s, 3H), 4.21(s, 2H)



5.13(s, 2H), 6.17(s, 1H), 6.60(dd, J=8.3, 1.4Hz, 1H), 6.70(d,



J=1.4Hz, 1H), 6.82(d, J=8.4Hz, 2H), 7.03(d, J=8.3Hz, 1H),



7.33–7.53(m, 7H), 9.07(brs, 1H), 9.45(brs, 1H)



IR(KBr)3390, 1609, 1592, 1522, 1484, 1247, 1227, 1119,



1011, 812 cm−1


I-567
m.p. 146–148° C.



1HNMR(DMSO-d6)δ 1.64(s, 3H), 1.70(s, 3H), 2.44(q, J=6.9Hz,



2H), 3.53(s, 3H), 3.78(s, 3H), 3.80(s, 3H), 4.05(t, J=6.9Hz,



2H), 5.26(t, J=6.9Hz, 2H), 7.05(s, 1H), 7.10(s, 1H), 7.19(d,



J=8.4Hz, 1H), 7.50(dd, J=8.4, 2.0Hz, 1H), 7.57(t, J=



8.3Hz, 1H), 7.65(ddd, J=8.3, 1.9, 0.9Hz, 1H), 7.66(dd, J=



11.9, 1.9Hz, 1H), 7.79(d, J=2.0Hz, 1H), 12.5(brs, 1H)



IR(KBr)3434, 3299, 1727, 1489, 1375, 1341, 1209, 1172,



1033, 851, 824 cm−1


I-568
m.p. 179–181° C.



1HNMR(CDCl3)δ 1.31(s, 9H), 3.11(s, 3H), 3.20(s, 3H), 3.39(s,



3H), 3.74(s, 3H), 5.16(s, 2H), 5.98(s, 1H), 6.79(s, 1H), 7.09(d,



J=8.5Hz, 1H), 7.29(dd, J=8.5, 1.9Hz, 1H), 7.35–7.49(m,



8H), 7.66(d, J=8.7Hz, 2H)



IR(KBr)3404, 3341, 1690, 1517, 1465, 1369, 1348, 1174,



1151, 869, 814 cm−1


I-569
m.p. 189–191° C.



1HNMR(DMSO-d6)δ 3.31(s, 3H), 3.33(s, 3H), 3.43(s, 3H),



3.64(s, 3H), 4.48(s, 2H), 5.25(s, 2H), 6.28(s, 1H), 7.24(dd,



J=9.0, 2.0Hz, 1H), 7.24(d, J=2.0Hz, 1H), 7.34–7.46



(m, 6H), 7.52–7.55(m, 2H), 7.70(d, J=9.0Hz, 2H)



IR(KBr)3490, 3392, 1596, 1518, 1483, 1364, 1150,



872, 813 cm−1


I-570
m.p. 194–196° C.



1HNMR(CDCl3)δ 3.07(s, 3H), 3.22(s, 3H), 3.36(s, 3H), 3.77(s,



3H), 5.16(s, 2H), 6.92(s, 1H), 7.13(d, J=8.6Hz, 1H), 7.25(dd,



J=8.6, 2.1Hz, 1H), 7.29(d, J=2.1Hz, 1H), 7.36–7.47(m,



7H), 7.63(brs, 1H), 7.67(d, J=8.4Hz, 2H)



IR(KBr)3433, 3329, 1737, 1518, 1476, 1369, 1168,



1148, 878 cm−1

















TABLE 114







I-571
m.p. 184–186° C.



1HNMR(CDCl3)δ 2.31(s, 3H), 2.38(s, 3H), 3.12(s, 3H),



3.45(s, 3H), 3.58(s, 3H), 3.76(s, 3H), 5.14(s, 2H), 6.95(s,



1H), 7.11–7.23(m, 5H), 7.34–7.37(m, 4H), 7.57(dd,



J=8.7, 2.4Hz, 1H), 7.66(d, J=2.4Hz, 1H)



IR(CHCl3)2952, 1732, 1614, 1599, 1518, 1467, 1445, 1370,



1290, 1256, 1169, 1117, 1081, 1064, 1003, 973, 905,



827 cm−1


I-572
m.p. 218–220° C.



1HNMR(CDCl3)δ 2.38(s, 3H), 3.12(s, 3H), 3.44(s, 3H),



3.63(s, 3H), 3.76(s, 3H), 5.14(s, 2H), 6.80–6.83(m, 2H),



6.94(s, 1H), 7.14(d, J=8.7Hz, 1H), 7.21–7.23(m, 4H), 7.35–



7.37(m, 2H), 7.56(dd, J=8.7, 2.4Hz, 1H), 7.66(d, J=2.4Hz, 1H)



IR(CHCl3)3596, 2939, 1720, 1613, 1522, 1466, 1445, 1370,



1346, 1291, 1258, 1183, 1172, 1116, 1081, 1064, 1003, 973,



904, 866, 837 cm−1


I-573
m.p. 197–199° C.



1HNMR(CD3OD)δ 3.19(s, 3H), 3.43(s, 3H), 3.76(s, 3H), 5.25(s,



2H), 7.06–7.12(m, 3H), 7.32–7.43(m, 6H), 7.52–7.54(m, 2H),



7.60((dd, J=8.4, 2.4Hz, 1H), 7.66(d, J=2.4Hz, 1H)



IR(KBr)3421, 2941, 1738, 1708, 1643, 1519, 1472, 1354,



1297, 1259, 1228, 1171, 1119, 1081, 1063, 1001, 958,



920, 871, 826, 755, 697, 524 cm−1


I-574
m.p. 151–153° C.



1HNMR(CDCl3)δ 2.39(s, 3H), 3.44(s, 3H), 3.64(s, 3H), 3.74(s,



3H), 5.12(s, 2H), 5.78(br, 2H), 6.78–6.81(m, 2H), 6.94(s, 1H),



6.99(d, J=8.4Hz, 1H), 7.15–7.25(m, 6H), 7.33–7.36(m, 2H)



IR(CHCl3)3595, 3541, 2952, 1730, 1612, 1591, 1521,



1474, 1395, 1345, 1323, 1290, 1258, 1173, 1129, 1081,



1063, 1004, 901, 863, 836 cm−1


I-575
m.p. 195–196° C.



1HNMR(CD3OD)δ 2.34(s, 3H), 3.40(s, 3H), 3.72(s, 3H), 5.16(s,



2H), 6.75–6.78(m, 2H), 6.96(s, 1H), 7.02(s, 1H), 7.14–



7.21(m, 6H), 7.36–7.39(m, 2H)



IR(KBr)3530, 3398, 2942, 1708, 1610, 1593, 1520, 1465,



1373, 1334, 1256, 1233, 1127, 1078, 1056, 996, 960,



864, 834, 791, 755, 690, 651, 605, 534 cm−1

















TABLE 115







I-576
m.p. 82–84° C.



1HNMR(CDCl3)δ 1.70(s, 3H), 1.75(s, 3H), 2.54–2.59(m, 2H),



3.24(s, 3H), 3.50(s, 3H), 3.77(s, 3H), 4.10(t, J=6.9Hz, 2H),



5.23(m, 1H), 7.07–7.12(m, 4H), 7.23–7.28(m, 2H), 7.57(dd,



J=8.7, 2.4Hz, 1H), 7.63(d, J=2.4Hz, 1H), 9.99(s, 1H)



IR(CHCl3)2936, 1697, 1604, 1591, 1518, 1469,



1445, 1371, 1331, 1294, 1232, 1172, 1159, 1123, 1093,



1005, 964 cm−1


I-577
m.p. 126–128° C.



1HNMR(CD3OD)δ 1.70(s, 3H), 1.74(d, J=0.9Hz, 3H),



2.53–2.61(m, 2H), 3.25(s, 3H), 3.44(s, 3H), 3.75(s, 3H), 4.13(t,



J=6.3Hz, 2H), 5.29(m, 1H), 7.04–7.11(m, 3H), 7.24(d, J=



8.7Hz, 1H), 7.33–7.38(m, 2H), 7.58–7.65(m, 2H)



IR(KBr)3432, 2940, 2566, 1735, 1711, 1646, 1613, 1519,



1470, 1447, 1366, 1297, 1264, 1228, 1172, 1118, 1081, 1063,



1001, 962, 920, 898, 871, 828, 796, 695, 524 cm−1


I-578
m.p. 202–204° C.



1HNMR(CDCl3)δ 3.13(s, 3H), 3.45(s, 3H), 3.61(s, 3H), 3.76(s,



3H), 5.19(s, 2H), 6.95(s, 1H), 7.05–7.11(m, 2H), 7.14(d, J=



8.7Hz, 1H), 7.30–7.49(m, 7H), 7.57(dd, J=8.7, 2.4Hz, 1H), 7.67



(d, J=2.4Hz, 1H)



IR(CHCl3)2952, 1731, 1603, 1519, 1472, 1445, 1371,



1345, 1291, 1172, 1159, 1117, 1081, 1064, 1004, 972,



960, 904 cm−1


I-579
m.p. 197–199° C.



1HNMR(CDCl3)δ 2.71(s, 3H), 3.56, (s, 3H), 3.75(s, 3H), 5.18



(s, 2H), 5.72, (s, 1H), 6.86(s, 1H), 7.00(d, J=8.4Hz, 1H),



7.12–7.18(m, 3H), 7.24(d, J=2.1Hz, 1H), 7.38–7.46(m, 7H)



IR(CHCl3)3543, 2939, 1602, 1521, 1482, 1465, 1394,



1370, 1328, 1254, 1178, 1159, 1130, 1081, 1005, 964,



840, 816 cm−1


I-580
m.p. 199–201° C.



1HNMR(CD3OD)δ 3.40(s, 3H), 3.73(s, 6H), 5.22(s, 2H), 7.00(s,



1H), 7.03–7.11(m, 4H), 7.17(m, 1H), 7.31–7.41(m, 5H),



7.49–7.52(m, 2H)



IR(KBr)3527, 3434, 2940, 1701, 1591, 1518, 1465, 1380, 1335,



1320, 1291, 1270, 1222, 1161, 1130, 1078, 1056, 1002, 916,



868, 837, 747, 698, 633, 599, 526, 480 cm−1

















TABLE 116







I-581
m.p. 122–123° C.



1HNMR(CDCl3)δ 1.78(s, 3H), 1.82(s, 3H), 3.25(s, 3H), 3.50(s,



3H), 3.76(s, 3H), 4.66(d, J=6.9Hz, 2H), 5.52(m, 1H), 7.09–7.14



(m, 4H), 7.23–7.27(m, 2H), 7.56(dd, J=8.7, 2.1Hz, 1H), 7.63(d,



J=2.1Hz, 1H), 9.99(s, 1H)



IR(CHCl3)2938, 1679, 1604, 1591, 1517, 1469, 1445,



1371, 1331, 1292, 1172, 1159, 1122, 1092, 1004, 973 cm−1


I-582
m.p. 158–159° C.



1HNMR(CDCl3)δ 2.69(s, 3H), 3.13(s, 3H), 3.57(s, 3H), 3.76(s,



3H), 5.19(s, 2H), 6.85(s, 1H), 7.13–7.18(m, 3H), 7.37–7.49



(m, 7H), 7.56(dd, J=9.0, 2.1Hz, 1H), 7.62(d, J=2.1Hz, 1H)



IR(CHCl3)2939, 1603, 1521, 1482, 1464, 1294, 1253,



1177, 1119, 1082, 1003, 963, 876, 842 cm−1


I-583
m.p. 145–147° C.



1HNMR(CDCl3)δ 2.68(s, 3H), 3.54(s, 3H), 3.56(s, 3H), 3.75(s,



3H), 5.21(s, 2H), 5.27(s, 2H), 6.85(s, 1H), 7.00(d, J=8.7Hz,



1H), 7.13–7.23(m, 3H), 7.33–7.49(m, 8H)



IR(CHCl3)2938, 1731, 1603, 1520, 1482, 1370, 1249,



1178, 1158, 1134, 1081, 1004, 961, 840, 815 cm−1


I-584
m.p. 160–162° C.



1HNMR(CDCl3)δ 3.47(s, 3H), 3.74(s, 3H), 5.18(s, 2H), 5.72(s,



1H), 6.00(s, 1H), 6.46(s, 1H), 7.01(d, J=8.4Hz,1H), 7.10–



7.19(m, 3H), 7.27(d, J=2.1Hz, 1H), 7.36–7.48(m, 7H)



IR(CHCl3)3540, 2938, 1603, 1568, 1522, 1490, 1464,



1416, 1396, 1325, 1263, 1158, 1111, 1072, 1002, 838 cm−1


I-585
m.p. 133–134° C.



1HNMR(CD3OD)δ 1.80(d, J=0.9Hz, 3H), 1.82(d, J=0.9Hz,



3H), 3.26(s, 3H), 3.44(s, 3H), 3.76(s, 3H), 4.71(d, J=6.9Hz,



2H), 5.55(m, 1H), 7.06–7.12(m, 3H), 7.26(d, J=8.7Hz, 1H),



7.34–7.36(m, 2H), 7.58–7.63(m, 2H)



IR(KBr)3422, 2939, 1736, 1702, 1603, 1519, 1472, 1368, 1293,



1228, 1187, 1173, 1117, 1081, 1061, 1003, 975, 961, 920,



827, 759, 701, 523 cm−1

















TABLE 117







I-586
m.p. 152–153° C.



1HNMR(CDCl3)δ 1.69(s, 3H), 1.74(d, J=0.9Hz, 3H), 2.55–



2.57(m, 2H), 3.23(s, 3H), 3.44(s, 3H), 3.60(s, 3H), 3.77(s, 3H),



4.09(t, J=6.6Hz, 2H), 5.22(m, 1H), 6.95(s, 1H), 7.05–7.11



(m, 3H), 7.30–7.35(m, 2H), 7.57(dd, J=8.7, 2.4Hz, 1H),



7.64(d, J=2.4Hz, 1H)



IR(CHCl3)2938, 1731, 1601, 1519, 1469, 1445, 1370,



1345, 1291, 1172, 1159, 1117, 1081, 1064, 1004, 973, 904,



864, 840 cm−1


I-587
m.p. 132–133° C.



1HNMR(CDCl3)δ 3.44(s, 3H), 3.61(s, 3H), 3.75(s, 3H), 5.18(s,



2H), 5.71(s, 1H), 6.95(s, 1H), 6.99–7.10(m, 3H), 7.17(dd, J=



8.4, 2.1Hz, 1H), 7.25–7.47(m, 8H)



IR(CHCl3)3542, 2952, 2938, 1731, 1597, 1519, 1474,



1392, 1345, 1321, 1290, 1266, 1159, 1130, 1080, 1063, 1000,



900, 862, 839 cm−1


I-588
m.p. 92–94° C.



1HNMR(CDCl3)δ 1.69(d, J=0.6Hz, 3H), 1.76(d, J=1.2Hz,



3H), 2.51–2.58(m, 2H), 3.45(s, 3H), 3.75(s, 3H), 4.09(t, J=



6.9Hz, 2H), 5.23(m, 1H), 5.70(br, 1H), 6.92(d, J=8.4Hz, 1H),



6.97(s, 1H), 7.05–7.10(m, 2H), 7.16(dd, J=8.4, 2.1Hz,



1H), 7.23(d, J=2.1Hz, 1H), 7.33–7.38(m, 2H)



IR(KBr)3534, 3432, 2936, 1713, 1597, 1519, 1473, 1377, 1322,



1260, 1231, 1158, 1130, 1081, 1063, 1004, 961, 919, 837,



808, 791, 754, 705, 521 cm−1


I-589
m.p. 120–122° C.



1HNMR(CDCl3)δ 1.69(s, 3H), 1.76(s, 3H), 2.51–2.58(m,



2H), 3.44(s, 3H), 3.61(s, 3H), 3.75(s, 3H), 4.09(t, J=6.6Hz,



2H), 5.23(m, 1H), 5.73(s, 1H), 6.92(d, J=8.4Hz, 1H), 6.96(s,



1H), 7.04–7.10(m, 2H), 7.16(dd, J=8.1, 1.8Hz, 1H), 7.23(d,



J=1.8Hz, 1H), 7.31–7.36(m, 2H)



IR(CHCl3)3541, 2937, 1731, 1598, 1519, 1471, 1391, 1345,



1323, 1290, 1265, 1159, 1130, 1080, 1063, 1005, 839 cm−1


I-590
m.p. 154–156° C.



1HNMR(CDCl3)δ 1.77(s, 3H), 1.82(s, 3H), 3.24(s, 3H), 3.45(s,



3H), 3.61(s, 3H), 3.76(s, 3H), 4.64(d, J=7.2Hz, 2H), 5.51(m,



1H), 6.95(s, 1H), 7.05–7.11(m, 3H), 7.31–7.35(m, 2H), 7.57(dd,



J=8.7, 2.4Hz, 1H), 7.64(d, J=2.4Hz, 1H)



IR(CHCl3)2938, 1731, 1602, 1519, 1472, 1445, 1370, 1345,



1290, 1186, 1116, 1080, 1064, 1003, 973, 904, 840 cm−1

















TABLE 118







I-591
m.p. 181–182° C.



1HNMR(CD3OD)δ 1.77(s, 3H), 1.80(d, J=0.9Hz, 3H), 3.42(s,



3H), 3.74(s, 3H), 4.65(d, J=6.9Hz, 2H), 5.55(m, 1H), 6.99–7.11



(m, 5H), 7.15(d, J=2.1Hz, 1H), 7.32–7.36(m, 2H)



IR(KBr)3529, 3424, 2937, 1714, 1598, 1519, 1473, 1417, 1372,



1336, 1321, 1258, 1235, 1157, 1129, 1080, 1062, 1004, 989,



917, 854, 839, 807, 791, 752, 703 cm−1


I-592
m.p. 109–110° C.



1HNMR(CDCl3)δ 1.78(s, 3H), 1.83(s, 3H), 3.44(s, 3H), 3.61(s,



3H), 3.75(s, 3H), 4.63(d, J=6.6Hz, 2H), 5.53(m, 1H), 5.72(s,



1H), 6.94(d, J=8.1Hz, 1H), 6.96(s, 1H), 7.04–7.10(m, 2H),



7.16(dd, J=8.4, 2.1Hz, 1H), 7.23(d, J=2.1Hz, 1H),



7.31–7.36(m, 2H)



IR(CHCl3)3538, 2938, 1731, 1598, 1519, 1473, 1391,



1345, 1290, 1264, 1159, 1129, 1080, 1063, 1004, 900,



862, 839 cm−1


I-593
m.p. 185–187° C.



1HNMR(CDCl3)δ 3.78(s, 3H), 3.80(s, 3H), 4.82(s, 1H), 6.61(m,



1H), 6.88–6.93(m, 2H), 6.96(s, 1H), 7.04(s, 1H), 7.23–7.25(m,



1H), 7.45(d, J=0.9Hz, 1H), 7.48–7.53(m, 2H), 7.83(d, J=0.9Hz,



1H), 8.18(brs, 1H)



IR(KBr)3600–3200(br), 1611, 1523, 1496, 1464, 1447, 1388,



1268, 1239, 1202, 1046, 1025 cm−1


I-594
m.p. 188–189° C.



1HNMR(CDCl3)δ 3.19(s, 3H), 3.79(s, 3H), 3.81(s, 3H), 6.61–



6.62(m, 1H), 6.96(s, 1H), 7.06(s, 1H), 7.24–7.26(m, 1H), 7.33–



7.37(m, 2H), 7.45(brs, 2H), 7.64–7.68(m, 2H), 7.84(d, J=0.9Hz,



1H), 8.21(brs, 1H)



IR(KBr)3600–3200(br), 1518, 1494, 1465, 1419, 1389, 1351,



1331, 1314, 1213, 1177, 1145, 1051, 1027 cm−1


I-595
m.p. 98–101° C.



1HNMR(CDCl3)δ 1.77(s, 3H), 1.78(s, 3H), 1.82(s, 3H), 1.85(s,



3H), 3.78(s, 3H), 3.79(s, 3H), 4.56(d, J=6.9Hz, 2H), 4.72(d, J=



6.9Hz, 2H), 5.39–5.44(m, 1H), 5.52–5.57(m, 1H), 6.53(d,



J=3.0Hz, 1H), 6.97–7.03(m, 4H), 7.12(d, J=3.3Hz, 1H),



7.38(d, J=8.4Hz, 1H), 7.45(dd, J=1.8, 8.7Hz, 1H),



7.52–7.57(m, 2H), 7.81(d, J=1.5Hz, 1H)



IR(KBr)3600-2800(br), 1606, 1498, 1476, 1463, 1382, 1262,



1241, 1206, 1177, 1052, 1030 cm−1

















TABLE 119







I-596
m.p. 207–210° C.



1HNMR(CDCl3)δ 3.19(s, 3H), 3.80(s, 3H), 3.81(s, 3H), 5.50(s,



2H), 6.65(d, J=3.0Hz, 1H), 6.81(d, J=7.8Hz, 1H), 6.96(s, 1H),



7.05(s, 1H), 7.19–7.22(m, 1H), 7.25–7.45(m, 6H), 7.54–7.60(m,



1H), 7.64–7.69(m, 2H), 7.86(brs, 1H), 8.61–8.64(m, 1H)



IR(KBr)3600–3200(br), 1496, 1478, 1364, 1347, 1210, 1176,



1155, 1052, 1028 cm−1


I-597
m.p. 222–224° C.



1HNMR(CDCl3)δ 2.36(s, 3H), 2.53(s, 3H), 3.77(s, 3H), 3.78(s,



3H), 6.69(dd, J=0.9, 4.2Hz, 1H), 6.95(s, 1H), 6.96(s, 1H),



7.23–7.28(m, 2H), 7.31–7.35(m, 2H), 7.51–7.54(m, 3H),



7.59(d, J=3.3Hz, 1H), 7.73(d, J=1.2Hz, 1H), 7.80–7.84(m,



2H), 8.03(d, J=1.2Hz, 1H)



IR(KBr)3600–3200(br), 1509, 1487, 1464, 1444, 1366, 1208,



1172, 1129, 1092, 1049, 1028 cm−1


I-598
m.p. 126–127° C.



1HNMR(CDCl3)δ 1.69(s, 3H), 1.71(d, J=0.9Hz, 3H), 2.56(dt,



J=6.6, 6.9Hz, 2H), 3.20(s, 3H), 3.22(s, 3H), 4.08(t, J=6.9Hz,



2H), 5.21(m, 1H), 7.08(d, J=8.4Hz, 1H), 7.18–7.27(m, 2H),



7.36–7.43(m, 2H), 7.50(dd, J=1.8, 8.4Hz, 1H), 7.56(d, J=1.8Hz,



1H), 7.59–7.66(m, 2H)



IR(KBr)1528, 1488, 1469, 1395, 1362, 1342, 1297, 1265, 1201,



1176, 1152, 1116, 968, 890, 872, 818 cm−1


I-599
m.p. 169–170° C.



1HNMR(DMSO-d6)δ 2.32(s, 3H), 3.37(s, 3H), 3.45(s, 3H), 5.23



(s, 2H), 7.23(d, J=7.8Hz, 2H), 7.37–7.44(m, 3H), 7.47–7.53(m,



2H), 7.56–7.66(m, 4H), 7.75(d, J=7.5Hz, 2H)



IR(KBr)1525, 1485, 1366, 1355, 1291, 1262, 1181, 1150,



1116, 969, 869, 811 cm−1


I-600
m.p. 123–124° C.



1HNMR(CDCl3)δ 1.68(s, 3H), 1.75(d, J=0.9Hz, 3H), 2.53(dt,



J=7.2, 6.9Hz, 2H), 4.07(t, J=6.9Hz, 2H), 4.91(s, 1H), 5.22(m,



1H), 5.72(s, 1H), 6.89–6.95(m, 2H), 7.07(m, 1H), 7.14–7.22(m,



4H), 7.44–7.51(m, 2H)



IR(KBr)3448, 1612, 1593, 1530, 1489, 1475, 1401, 1262,



1212, 1181, 1169, 1132, 839, 779 cm−1

















TABLE 120







I-601
m.p. 184–185° C.



1HNMR(DMSO-d6)δ 2.31(s, 3H), 5.13(s, 2H), 6.85–6.91(m,



2H), 6.97(m, 1H), 7.07(d, J=8.4Hz, 1H), 7.07(d, J=1.8Hz, 1H),



7.20(d, J=8.1Hz, 2H), 7.32–7.48(m, 6H)



IR(KBr)3290, 1614, 1529, 1491, 1459, 1449, 1405, 1380,



1267, 1254, 1167, 1132, 783 cm−1


I-602
m.p. 141–142° C.



1HNMR(CDCl3)δ 1.77(s, 3H), 1.82(s, 3H), 3.46(s, 3H), 3.78(s,



3H), 4.56(d, J=6.8Hz, 2H), 5.54(t, J=6.6Hz, 1H), 6.96–7.26(m,



7H), 7.61(dd, J=5.2, 8.6Hz, 2H), 9.88(s, 1H)



IR(KBr)3433, 2955, 2922, 2865, 2833, 1687, 1604, 1515,



1462, 1288, 1258, 1232, 1180, 1160, 1070, 998, 845 cm−1


I-603
m.p. 169–170° C.



1HNMR(CDCl3)δ 2.38(s, 3H), 3.46(s, 3H), 3.77(s, 3H), 5.07(s,



2H), 7.02–7.38(m, 7H), 7.61(dd, J=5.4, 8.8Hz, 2H), 9.89



(brs, 1H)



IR(KBr)3433, 2936, 2840, 1698, 1517, 1462, 1251, 1233,



1067, 999, 837 cm−1


I-604
m.p. 120–121° C.



1HNMR(CDCl3)δ 1.68(s, 3H), 1.74(s, 3H), 2.50–2.57(m,



2H), 3.46(s, 3H), 3.77(s, 3H), 3.98(t, J=7.0Hz, 2H), 5.24(t,



J=7.0Hz, 1H), 6.94–7.26(m, 7H), 7.61(dd, J=5.4, 8.8Hz,



2H), 9.88(brs, 1H)



IR(KBr)3435, 2960, 2937, 2876, 1698, 1605, 1516, 1464, 1441,



1379, 1296, 1272, 1233, 1221, 1161, 1073, 1024, 845, 807 cm−1


I-605
m.p. 151–152° C.



1HNMR(DMSO-d6)δ 1.34(s, 6H), 3.07–3.15(m, 1H), 3.32(s,



3H), 3.67(s, 3H), 3.97–4.08(m, 1H), 4.28–4.34(m, 1H),



6.48(s, 1H), 7.00(d, J=7.8Hz, 2H), 7.22–7.35(m, 4H),



7.66(dd, J=3.2, 6.0Hz, 2H), 8.72(brs, 1H)



IR(KBr)3460, 2960, 2935, 1607, 1521, 1488, 1456, 1392, 1244,



1226, 1160, 1122, 1073, 818 cm−1


I-606
m.p. 164–165° C.



1HNMR(DMSO-d6)δ 2.32(s, 3H), 3.31(s, 3H), 3.66(s, 3H),



5.08(s, 2H), 6.46(s, 1H), 6.99(d, J=5.8Hz, 2H), 7.20–7.38(m,



4H), 7.65(dd, J=3.6, 6.2Hz, 2H), 8.69(brs, 1H)



IR(KBr)3367, 2940, 1605, 1519, 1484, 1466, 1449, 1390, 1229,



1181, 1158, 1059, 1006, 987, 831, 817 cm−1

















TABLE 121







I-607
m.p. 103–104° C.



1HNMR(DMSO-d6)δ 1.37(s, 6H), 2.47–2.59(m, 2H), 3.31(s, 3H),



3.66(s, 3H), 3.94–4.05(m, 1H), 4.26–4.34(m, 1H), 6.44(s, 1H),



7.02(d, J=7.6Hz, 2H), 7.18–7.35(m, 4H), 7.64(dd, J=3.4, 6.6Hz,



2H), 8.77(brs, 1H)



IR(KBr)3400, 2993, 2961, 2930, 1607, 1522, 1486, 1471, 1454,



1393, 1226, 1123, 1072, 835, 819cm−1


I-608
m.p. 157–158° C.



1HNMR(DMSO-d6)δ 1.73(s, 3H), 1.77(s, 3H), 3.31(s, 3H), 3.72(s,



3H), 4.54(d, J=6.9Hz, 2H), 5.47(t, J=7.2Hz, 1H), 6.93(d, J=8.7Hz,



2H), 7.05(s, 1H), 7.19(d, J=9.0Hz, 2H), 7.30–7.36(m, 2H), 7.70



(dd, J=5.4, 8.7Hz, 2H)



IR(KBr)3406, 2936, 1712, 1608, 1519, 1472, 1444, 1375, 1235,



839cm−1


I-609
m.p. 215–216° C.



1HNMR(DMSO-d6)δ 2.34(s, 3H), 3.33(s, 3H), 3.74(s, 3H), 5.09(s,



2H), 7.00–7.07(m, 3H), 7.22–7.39(m, 8H), 7.73(dd, J=5.6, 8.0Hz,



2H)



IR(KBr)3494, 3289, 2938, 1745, 1698, 1520, 1471, 1461, 1378,



1296, 1239, 1183, 1159, 829cm−1


I-610
m.p. 169–170° C.



1HNMR(DMSO-d6)δ 1.64(s, 3H), 1.71(s, 3H), 2.41–2.46(m, 2H),



3.32(s, 3H), 3.73(s, 3H), 3.97(t, J=6.6Hz, 2H), 5.23(t, J=7.2Hz,



1H), 6.93(d, J=8.1Hz, 2H), 7.05(s, 1H), 7.20(d, J=7.2Hz, 2H),



7.30–7.36(m, 2H), 7.70(dd, J=4.5, 7.5Hz, 2H)



IR(KBr)3424, 2933, 1701, 1609, 1519, 1471, 1379, 1294, 1248,



1061, 839cm−1


I-611
m.p. 167–168° C.



1HNMR(CDCl3)δ 1.75(s, 3H), 1.82(s, 3H), 2.35(s, 6H), 2.45(s,



3H), 3.21(s, 3H), 3.56(s, 3H), 3.70(s, 3H), 4.35(d, J=6.9Hz, 2H),



5.60(t, J=7.2Hz, 1H), 6.84(s, 1H), 7.08(s, 2H), 7.38(d, J=8.7Hz,



2H), 7.70(d, J=9.0Hz, 2H)



IR(KBr)3433, 2932, 1509, 1475, 1376, 1359, 1232. 1177, 1152,



1085, 966, 874, 797cm−1

















TABLE 122







I-612
m.p. 175–176° C.



1HNMR(CDCl3)δ 2.35(s, 6H), 2.39(s, 3H), 2.49(s, 3H), 3.21(s,



3H), 3.56(s, 3h), 3.79(s, 3H), 4.83(s, 2H), 6.84(s, 1H), 7.10(s,



2H), 7.22(d, J=7.5Hz, 2H), 7.38(d, J=8.4Hz, 4H), 7.70(d, J=9.0Hz,



2H)



IR(KBr)3434, 2936, 1510, 1475, 1363, 1229, 1176, 1152, 1083,



964, 871, 803cm−1


I-613
m.p. 138–139° C.



1HNMR(CDCl3)δ 1.69(s, 3H), 1.75(s, 3H), 2.33(s, 6H), 2.52–2.55



(m, 2H), 3.21(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 3.79(t, J=6.9Hz,



2H), 5.27(t, J=6.6Hz, 1H), 6.83(s, 3H), 7.08(s, 6H), 7.38(d, J=8.7



Hz, 2H), 7.70(d, J=9.0Hz, 2H)



IR(KBr)3432, 2939, 1509, 1476, 1448, 1362, 1237, 1172, 1155,



1103, 1081, 963, 873, 800cm−1


I-614
m.p. 89–90° C.



1HNMR(DMSO-d6)δ 1.74(s, 3H), 1.77(s, 3h), 3.36(s, 3H), 3.67(s,



3H), 4.22(d, J=3.0Hz, 2H), 4.56(d, J=6.3Hz, 2H), 5.48(t, J=5.7Hz,



1H), 6.93–6.96(m, 3H), 7.11(d, J=8.7Hz, 2H), 7.28–7.34(m, 2H),



7.68(dd, J=6.0, 8.7Hz, 2H)



IR(KBr)3528, 3418, 2935, 1608, 1518, 1472, 1233, 1004,



836cm−1


I-615
m.p. 89–90° C.



1HNMR(DMSO-d6)δ 2.33(s, 3H), 3.36(s, 3H), 3.67(s, 3H), 4.22(d,



J=3.9Hz, 2H), 4.59(t, J=4.2Hz, 1H), 5.09(s, 2H), 6.94(s, 1H), 7.02



(d, J=8.4Hz, 2H), 7.22(d, J=8.4Hz, 4H), 7.28–7.39(m, 4H), 7.68



(dd, J=5.7, 8.4Hz, 2H)



IR(KBr)3485, 2931, 1517, 1473, 1460, 1383, 1243, 1225, 1079,



1014, 1001, 834, 798cm−1


I-616
oil



1HNMR(DMSO-d6)δ 1.75(s, 3H), 1.78(s, 3H), 2.47–2.52(m,



2H), 3.39(s, 3H), 3.71(s, 3H), 4.25(d, J=3.3Hz, 2H), 4.49(d, J=6.3



Hz, 2H), 5.46(t, J=5.7Hz, 1H), 6.91–6.95(m, 3H), 7.13(d, J=8.4



Hz, 2H), 7.24–7.32(m, 2H), 7.67(dd, J=5.7, 8.4Hz, 2H)



IR(KBr)3528, 3419, 2935, 1608, 1518, 1472, 1383, 1232, 1004,



837cm−1

















TABLE 123







I-617
m.p. 138–139° C.



1HNMR(DMSO-d6)δ 1.70(s, 3H), 1.77(s, 3H), 2.24(s, 6H), 3.30(s,



3H), 3.64(s, 3H), 4.31(d, J=6.9Hz, 2H), 5.56(t, J=6.6Hz, 1H), 6.39



(s, 1H), 6.84(d, J=8.4Hz, 2H), 6.91(s, 2H), 7.44(d, J=8.4Hz, 2H),



8.50(s, 1H), 9.50(s, 1H)



IR(KBr)3400, 2966, 2934, 1609, 1519, 1465, 1444, 1389, 1362,



1269, 1228, 1211, 1194, 1171, 1118, 1089, 1027, 953cm−1


I-618
m.p. 122–123° C.



1HNMR(DMSO-d6)δ 2.29(s, 6H), 2.37(s, 3H), 3.30(s, 3H), 3.67(s,



3H), 4.81(s, 2H), 6.43(s, 1H), 6.86(d, J=7.5Hz, 2H), 6.97(s, 2H),



7.27(d, J=6.9Hz, 2H), 7.42–7.48(m, 2H), 8.54(s, 1H), 9.52(s, 1H)



IR(KBr)3483, 3423, 2931, 1735, 1709, 1612, 1520, 1477, 1454,



1411, 1395, 1362, 1224, 1176, 1117, 1089, 1028cm−1


I-619
m.p. 81–82° C.



1HNMR(DMSO-d6)δ 1.70(s, 3H), 1.76(s, 3H), 2.18–2.30(m, 2H),



2.27(s, 6H), 3.34(s, 3H), 3.68(s, 3H), 3.80(t, J=4.5Hz, 2H), 5.34(t,



J=5.1Hz, 1H), 6.43(s, 1H), 6.88(d, J=7.5Hz, 2H), 6.94(s, 6H),



7.46–7.50(m, 2H), 8.53(s, 1H), 9.54(s, 1H)



IR(KBr)3410, 2930, 1612, 1521, 1479, 1454, 1395, 1361, 1265,



1227, 1174, 1117, 1090, 1028, 825cm−1


I-620
m.p. 161–162° C.



1HNMR(CDCl3)δ 1.32(s, 9H), 2.38(s, 3H), 3.10(s, 3H), 3.20(s,



3H), 3.39(s, 3H), 3.74(s, 3H), 5.12(s, 2H), 5.96(s, 1H), 6.79(s,



1H), 7.09(d, J=8.4Hz, 1H), 7.21(d, J=7.8Hz, 2H), 7.28(dd, J=8.4,



1.8Hz, 1H), 7.33–7.38(m, 5H), 7.67(d, J=8.4Hz, 2H)



IR(KBr)3398, 1718, 1518, 1472, 1366, 1173, 1151, 877, 867,



813cm−1


I-621
m.p. 139–141° C.



1HNMR(CDCl3)δ 1.33(s, 9H), 1.68(s, 3H), 1.74(s, 3H), 2.54(q, J=



6.9Hz, 2H), 3.19(s, 3H), 3.20(s, 3H), 3.39(s, 3H), 3.73(s, 3H),



4.05(t, J=6.9Hz, 2H), 5.21(t, J=6.9Hz, 1H), 5.95(s, 1H), 6.79(s,



1H), 7.02(d, J=8.4Hz, 1H), 7.29(dd, J=8.4, 1.9Hz, 1H), 7.33(d, J=



1.9Hz, 1H), 7.36(d, J=8.7Hz, 2H), 7.66(d, J=8.7Hz, 2H)



IR(KBr)3416, 1720, 1519, 1469, 1365, 1237, 1152, 1117, 975,



872, 815cm−1

















TABLE 124







I-622
m.p. 197–199° C.



1HNMR(DMSO-d6)δ 2.33(s, 3H), 3.31(s, 6H), 3.43(s, 3H), 3.64(s,



3H), 3.74(s, 3H), 4.47(s, 2H), 5.19(s, 2H), 6.28(s, 1H), 7.21–7.25



(m, 4H), 7.35(d, J=8.7Hz, 1H), 7.40–7.44(m, 4H), 7.70(d, J=9.0



Hz, 2H)



IR(KBr)3482, 3385, 1597, 1519, 1484, 1368, 1353, 1150, 872,



813cm−1


I-623
m.p. 99–101° C.



1HNMR(DMSO-d6)δ 2.32(s, 3H), 3.27(s, 3H), 3.59(s, 3H), 4.21(s,



2H), 5.08(s, 2H), 6.17(s, 1H), 6.58(dd, J=8.0, 1.8Hz, 1H), 6.69(d,



J=1.8Hz, 1H), 6.82(d, J=8.7Hz, 2H), 7.01(d, J=8.0Hz, 1H), 7.21(d,



J=7.8Hz, 2H), 7.39(d, J=7.8Hz, 2H), 7.41(d, J=8.7Hz, 2H), 9.02



(brs, 1H), 9.45(brs, 1H)



IR(KBr)3390, 1609, 1592, 1521, 1484, 1246, 1227, 1117, 1011,



810cm−1


I-624
m.p. 215–217° C.



1HNMR(CDCl3+CD3OD)d3.78(s, 3H), 3.79(s, 3H), 5.49(s, 2H),



6.64(dd, J=0.6, 2.7Hz, 1H), 6.79(d, J=8.1Hz, 1H), 6.90(d, J=8.7



Hz, 2H), 6.96(s, 1H), 7.02(s, 1H), 7.19–7.32(m, 3H), 7.40–7.50



(m, 3H), 7.56–7.60(m, 1H), 7.85(d, J=0.9Hz, 1H), 8.58–8.60



(m, 1H)



IR(KBr)3600–2600(br), 1611, 1599, 1500, 1477, 1445, 1395,



1264, 1238, 1210, 1052, 1029, 1008cm−1


I-625
m.p. 213–214° C.



1HNMR(CDCl3)δ 2.36(s, 3H), 3.77(s, 6H), 6.70(dd, J=0.6, 3.6Hz,



1H), 6.93(s, 1H), 6.96(s, 1H), 7.08–7.16(m, 2H), 7.24–7.28(m,



2H), 7.51–7.60(m, 4H), 7.73(d, J=1.5Hz, 1H), 7.80–7.84(m, 2H),



8.03(d, J=9.0Hz, 1H)



IR(KBr)3600–2800(br), 1597, 1517, 1496, 1464, 1444, 1372,



1209, 1189, 1172, 1157, 1121, 1092, 1050, 1028cm−1


I-626
1HNMR(CDCl3+CD3OD)δ 3.13(s, 3H), 3.81(s, 3H), 3.82(s, 3H),



5.19(s, 2H), 6.97(s, 1H), 6.99(s, 1H), 7.14(d, J=8.7Hz, 1H), 7.34–



7.52(m, 6H), 7.61(d, J=2.1Hz, 1H), 7.73(d, J=8.4Hz, 2H), 8.12(d,



J=8.4Hz, 2H)



IR(KBr)3432, 1616, 1520, 1494, 1452, 1388, 1352, 1282, 1261,



1211, 1186, 1175, 1113, 1058, 1033cm−1


I-627
1HNMR(CDCl3)δ 3.81(s, 6H), 5.17(s, 2H), 6.99(s, 1H), 7.00(d, J=



8.4Hz, 1H), 7.09(dd, J=8.4&1.8Hz, 1H), 7.23(d, J=1.8Hz, 1H),



7.33–7.50(m, 5H), 7.76(.d, J=8.4Hz, 2H), 8.10(d, J=8.4Hz, 2H)



IR(KBr)3551, 3520, 3399, 1615, 1587, 1576, 1521, 1488, 1455,



1383, 1268, 1245, 1208, 1126, 1055, 1034, 1003cm−1

















TABLE 125







I-628
1HNMR(CDCl3)δ 3.05(s, 3H), 3.47(s, 3H), 3.75(s, 3H), 5.15(s,



2H), 6.45(s, 1H), 6.94(dd, J=8.4&1.8Hz, 1H), 7.03(d,



J=8.4Hz, 1H), 7.06(d, J=1.8Hz, 1H), 7.30(d, J=8.1Hz, 2H),



7.36–7.51(m, 5H), 7.63(d, J=8.1Hz, 2H)



IR(KBr)3525, 3472, 1609, 1588, 1522, 1487, 1455, 1407,



1321, 1286, 1242, 1148, 1115, 1071, 1013 cm−1


I-629
1HNMR(CDCl3)δ 2.68(s, 3H), 3.07(s, 3H), 3.14(s, 3H), 3.55(s,



3H), 3.78(s, 3H), 5.19(s, 2H), 6.85(s, 1H), 7.16(d, J=



8.7Hz, 1H), 7.27–7.50(m, 9H), 7.62(d, J=9.0Hz, 2H)



IR(KBr)3432, 1611, 1522, 1482, 1462, 1392, 1358, 1295,



1233, 1178, 1154, 1119, 1082, 1012 cm−1


I-630
1HNMR(CDCl3)δ 2.88(s, 3H), 3.08(s, 3H), 3.28(s, 3H), 3.30(s,



3H), 3.54(s, 3H), 3.79(s, 3H), 6.87(s, 1H), 7.32(d,



J=8.4Hz, 2H), 7.43(d.d, J=8.4&2.1Hz, 1H), 7.54–



7.65(m, 4H)



IR(KBr)3432, 1612, 1519, 1481, 1367, 1332, 1232,



1177, 1154, 1077, 1011 cm−1


I-631
1HNMR(CDCl3)δ 1.57(s, 3H), 1.69(s, 3H), 2.66(s, 3H), 2.97(s,



3H), 3.13(s, 3H), 3.54(s, 3H), 3.77(s, 3H), 4.31(d, J=7.2Hz, 



2H), 5.19(s, 2H), 5.21–5.32(m, 1H), 6.86(s, 1H), 7.15(d,



J=8.7Hz, 1H), 7.30–7.52(m, 9H), 7.63(d, J=8.4Hz, 2H)



IR(KBr)1609, 1520, 1481, 1365, 1338, 1294, 1270, 1233,



1178, 1153, 1118, 1078, 1015, 947 cm−1


I-632
1HNMR(CDCl3)δ 1.45(s, 3H), 1.59(s, 3H), 1.66(s, 3H), 1.70(s,



3H), 2.97(s, 3H), 3.11(s, 3H), 3.64(s, 3H), 3.75(s,



3H), 4.28(d, J=8.4Hz, 2H), 4.32(d, J=8.4Hz, 2H), 5.18



(s, 2H), 5.23(t, J=8.4Hz, 1H)), 5.29(t, J=8.4Hz,



1H), 6.70(s, 1H), 7.10(d, J=8.4Hz, 1H), 7.30–7.51



(m, 9H), 7.58(d, J=8.4Hz, 2H)


I-633
1HNMR(CDCl3)δ 1.58(s, 3H), 1.69(s, 3H), 2.97(s, 3H), 3.45(s,



3H), 3.75(s, 3H), 4.33(d, J=7.5Hz, 2H), 5.16(s, 2H),



5.24–5.33(m, 1H), 5.69(s, 1H), 5.87(s, 1H), 6.47(s, 1H),



6.95(d.d, J=8.4&2.1Hz, 1H), 7.03(d, J=8.4Hz, 1H),



7.09(.d, J=2.1Hz, 1H), 7.31–7.50(m, 7H), 7.65(d,



J=8.4Hz, 2H)



IR(KBr)3450, 1609, 1590, 1558, 1524, 1487, 1448, 1421,



1320, 1233, 1143, 1117, 1073, 1019 cm−1


I-634
1HNMR(CDCl3)δ 1.57(s, 3H), 1.68(s, 3H), 2.66(s, 3H), 2.70(s,



3H), 3.13(s, 3H), 3.54(s, 3H), 3.78(s, 3H), 4.33(d, J=



8.4Hz, 2H), 5.19(s, 2H), 5.26(t, J=8.4Hz), 6.86(s, 1H),



7.15(d, J=8.7Hz, 1H), 7.30–7.49(m, 9H), 7.63(d,



J=8.4Hz, 2H)



IR(KBr)1615, 1517, 1480, 1372, 1337, 1233, 1213, 1178,



1154, 1076, 1014 cm−1

















TABLE 126







I-635
1HNMR(CDCl3)δ 1.58(s, 3H), 1.69(s, 3H), 2.82(s, 3H), 2.97(s,



3H), 3.29(s, 3H), 3.53(s, 3H), 3.77(s, 3H), 4.33(d, J=7.2Hz, 2H),



5.27(t, J=7.2Hz, 1H), 6.25(s, 1H), 6.86(s, 1H), 7.17(d, J=9.0Hz,



1H)), 7.23–7.32(m, 2H), 7.41(d, J=8.7Hz, 2H), 7.63(d, J=8.7Hz,



2H)



IR(KBr)3431, 1611, 1522, 1482, 1364, 1337, 1294, 1231, 1178,



1153, 1077, 1014cm−1


I-636
1HNMR(CDCl3)δ 1.76(s, 3H), 1.82(s, 3H), 3.09(s, 3H), 3.47(s,



3H), 3.75(s, 3H), 4.62(d, J=6.9Hz, 2H), 5.47–5.58(m, 1H), 5.71(s,



1H), 5.87(s, 1H), 6.45(s, 1H), 6.60(s, 1H), 6.89–7.01(m, 2H),



7.05(d, J=0.6Hz, 1H), 7.30(.d, J=8.7Hz, 2H), 7.65(d, J=8.7Hz, 2H)



IR(KBr)3448, 3265, 1612, 1585, 1521, 1487, 1330, 1287, 1243,



1225, 1152, 1112, 1069, 971cm−1


I-637
1HNMzR(CDCl3)δ 1.57(s, 3H), 1.69(s, 3H), 1.77(s, 3H), 1.81(s,



3H), 2.70(s, 3H), 2.97(s, 3H), 3.24(s, 3H), 3.54(s, 3H), 3.78(s,



3H), 4.32(d, J=6.9Hz, 2H), 4.64(d, J=6.6Hz, 2H), 5.27(t, J=6.9Hz,



1H), 5.49(t, J=6.6Hz, 1H), 6.86(s, 1H), 7.09(d, J=8.4Hz, 1H),



7.32–7.44(m, 4H), 7.63(d, J=8.4Hz, 2H)



IR(KBr)1609, 1520, 1481, 1365, 1339, 1292, 1270, 1236, 1178,



1153, 1118, 1078, 1015cm−1


I-638
1HNMR(CDCl3)δ 1.58(s, 3H), 1.69(s, 3H), 1.76(s, 3H), 1.82(s,



3H), 2.97(s, 3H), 3.45(s, 3H), 3.75(s, 3H), 4.32(d, J=7.8Hz, 2H),



4.63(.d, J=7.8Hz, 2H), 5.23–5.33(m, 1H), 5.48–5.57(m, 1H), 5.69



(s, 1H), 5.85(s, 1H), 6.46(s, 1H), 6.89–7.02(m, 2H), 7.05(d, J=1.8



Hz, 1H), 7.40(d, J=8.7Hz, 2H), 7.65(d, J=8.7Hz, 2H)



IR(KBr)3450, 1609, 1588, 1557, 1525, 1487, 1445, 1327, 1248,



1148, 1114, 1072, 1015cm−1


I-639
1HNMR(CDCl3)δ 2.55(s, 3H), 2.67(s, 3H), 3.58(s, 3H), 3.79(s,



3H), 5.18(s, 2H), 5.71(s, 1H), 6.85(s, 1H), 6.91(d.d, J=8.4&



2.1Hz, 1H), 7.03(d, J=8.4Hz, 1H), 7.04(d, J=2.1Hz, 1H), 7.32–



7.48(m, 6H), .7.85(.d.d, J=7.8&1.5Hz, 1H), 8.22(d, J=1.5Hz, 1H)



IR(KBr)3457, 1739, 1529, 1481, 1407, 1376, 1346, 1279, 1243,



1177, 1128, 1071, 1012cm−1


I-640
1HNMR(CDCl3)δ 2.67(s, 3H), 2.68(s, 3H), 3.13(s, 3H), 3.58(s,



3H), 3.80(s, 3H), 5.19(s, 2H), 6.86(s, 1H), 7.15(d, J=8.7Hz, 1H),



7.31–7.49(m, 8H), 7.83(d.d, J=8.1&1.8Hz, 1H), 8.21(d, J=1.8Hz,



1H)



IR(KBr)3433, 1609, 1530, 1481, 1372, 1290, 1268, 1238, 1177,



1118, 1075, 1012cm−1

















TABLE 127







I-641
1HNMR(CDCl3)δ 2.67(s, 3H), 3.50(s, 3H), 3.77(s,



3H), 5.16(s, 2H), 5.70(s, 1H), 5.83(s, 1H), 6.47(s, 1H), 6.94



(d.d, J=8.7&1.8Hz, 1H), 7.04(d, J=8.7Hz, 1H), 7.07(d,



J=1.8Hz, 1H), 7.34–7.48(m, 5H), 7.82(d.d, J=8.1&



1.8Hz, 1H), 8.26(d, J=1.8Hz, 1H)



IR(KBr)3555, 3377, 1590, 1529, 1503, 1451, 1414, 1341,



1324, 1242, 1225, 1121 cm−1


I-642
1HNMR(CDCl3)δ 2.29(s, 3H), 2.68(s, 3H), 3.12(s, 3H), 3.56(s,



3H), 3.76(s, 3H), 5.18(s, 2H), 6.85(s, 1H), 7.00–7.20



(m, 4H), 7.31–7.49(m, 7H)



IR(KBr)3407, 1624, 1518, 1480, 1361, 1287, 1270, 1234,



1175, 1117, 1084, 1009 cm−1


I-643
1HNMR(CDCl3)δ 2.40(s, 3H), 2.67(s, 3H), 3.09(s, 3H), 3.13(s,



3H), 3.59(s, 3H), 3.78(s, 3H), 5.19(s, 1H), 6.17(s, 1H),



6.85(s, 1H), 7.15(d, J=8.4Hz, 1H), 7.30–7.49(m, 9H),



7.69(d, J=1.8Hz, 1H)



IR(KBr)3433, 3304, 1608, 1519, 1481, 1365, 1326, 1294,



1269, 1237, 1177, 1156, 1114, 1079, 1015 cm−1


I-644
1HNMR(CDCl3)δ 2.09(s, 3H), 2.39(s, 3H), 2.68(s, 3H), 3.13(s,



3H), 3.49(s, 3H), 3.76(s, 2H), 5.19(s, 2H), 6.30(s, 1H),



6.77(s, 1H), 7.12–7.24(m, 3H), 7.31–7.49(m, 9H), 7.54



(d, J=1.8Hz, 1H), 7.67(d, J=8.4Hz, 2H)



IR(KBr)3434, 1608, 1519, 1481, 1366, 1293, 1269, 1237,



1164, 1114, 1081, 1016 cm−1


I-645
1HNMR(CDCl3)δ 2.09(s, 3H), 2.39(s, 3H), 3.43(s, 3H), 3.73(s,



3H), 5.16(s, 2H), 5.30(s, 1H), 5.68(s, 1H), 5.89(s, 1H),



6.32(s, 1H), 6.36(s, 1H), 6.95(d.d, J=8.7&2.1Hz, 1H),



7.03(d, J=8.7Hz, 1H), 7.08(d, J=2.1Hz, 1H), 7.14–



7.28(m, 3H), 7.34–7.50(m, 5H), 7.61(.d, J=1.5Hz, 1H),



7.68(d, J=8.4Hz, 2H)



IR(KBr)3465, 3270, 1612, 1587, 1558, 1519, 1487, 1454,



1384, 1244, 1160, 1123, 1105, 1091, 1070, 1009 cm−1


I-646
1HNMR(CDCl3)δ 2.48(s, 3H), 2.63(s, 3H), 3.02(s, 3H), 3.13(s,



3H), 3.28(s, 2H), 3.54(s, 3H), 3.78(s, 3H), 5.19(s, 2H),



6.85(s, 1H), 7.15(d, J=8.4Hz, 1H), 7.30–7.49(m, 9H),



7.59(s, 1H)



IR(KBr)3433, 1606, 1519, 1481, 1364, 1341, 1292, 1272,



1233, 1178, 1148, 1118, 1082 cm−1


I-647
1HNMR(CDCl3)δ 2.48(s, 3H), 3.02(s, 3H), 3.28(s, 3H), 3.46(s,



3H), 3.75(s, 3H), 5.16(s, 2H), 5.70(s, 1H), 5.48(s, 1H),



6.47(s, 1H) 6.94(d.d, J=8.4&2.1Hz, 1H), 7.03(d, J=8.4Hz,



1H), 7.07(d, J=2.1Hz, 1H), 7.33–7.53(m, 7H), 7.62(d,



J=1.8Hz, 1H)



IR(KBr)3528, 3429, 1609, 1584, 1558, 1517, 1487, 1454,



1331, 1317, 1137, 1115, 1068, 1002 cm−1

















TABLE 128







I-648
1HNMR(CDCl3)δ 1.55(s, 3H), 2.45(s, 3H), 2.79(s, 3H), 3.02(s,



3H), 3.29(s, 3H), 3.52(s, 3H), 3.77(s, 3H), 4.12–4.31(m, 2H),



5.22–5.31(m, 1H), 6.30(s, 11H), 6.84(5, 1H), 7.17(d, J=8.7Hz,



1H), 7.25–7.32(m, 2H), 7.39(d, J=8.4Hz, 1H), 7.45(d.d, J=8.4&1.8



Hz, 1H), 7.53(d, J=1H), 1.8Hz, 1H)



IR(KBr)3431, 1609, 1522, 1481, 1365, 1334, 1294, 1235, 1178,



1150, 1077, 1013cm−1


I-649
1HNMR(CDCl3)δ 1.54(s, 3H), 1.68(s, 3H), 1.76(s, 3H), 1.81(s,



3H), 2.45(s, 3H), 2.68(s, 3H), 3.02(s, 3H), 3.24(s, 3H), 3.52(s,



3H), 3.78(s, 3H), 4.10–4.34(m, 2H), 4.64(d, J=7.2Hz, 2H), 5.21–



5.30(m, 1H), 5.45–5.53(m, 1H), 6.84(s, 1H), 7.08(d, J=8.4Hz,



1H), 7.31–7.48(m, 4H), 7.53(d, J=1.5Hz, 1H)



IR(KBr)3432, 1606, 1518, 1481, 1362, 1340, 1292, 1276, 1236,



1177, 1153, 1116, 1076, 1010cm−1


I-650
1HNMR(CDCl3)δ 1.56(s, 3H), 1.68(s, 3H), 1.76(s, 3H), 1.82(s,



3H), 2.44(s, 3H), 3.02(s, 3H), 3.45(s, 3H), 3.75(s, 3H), 4.10–4.32



(m, 2H), 4.62(d, J=7.2Hz, 2H), 5.22–5.32(m, 1H), 5.48–5.57(m,



1H), 5.60–5.80(brroad, 1H), 5.82(s, 1H), 6.46(s, 1H), 6.92(d.d, J=



8.1&1.8Hz, 1H), 6.97(d, J=8.1Hz, 1H), 7.04(d, J=1.8Hz, 1H), 7.38



(d, J=8.1Hz, 1H), 7.47(d.d, J=8.1&1.8Hz, 1H), 7.57(d, J=1.8Hz,



1H)



IR(KBr)3433, 1610, 1586, 1557, 1518, 1486, 1336, 1240, 1149,



1110, 1069cm−1


I-651
1HNMR(CD3OD)δ 3.33(s, 3H), 3.66(s, 3H), 5.18(s, 2H), 6.42(s,



1H), 1H), 6.75(dd, J=8.4&2.1Hz, 1H), 6.87(d, J=2.1Hz, 1H), 6.95



(d, J=8.4Hz, 1H), 7.26–7.58(m, 8H), 7.81(d.d, J=7.8&1.2Hz, 1H)



IR(KBr)3446, 1698, 1586, 1517, 1498, 1481, 1454, 1408, 1287,



1247, 1117, 1069, 1010cm−1


I-652
1HNMR(CDCl3)δ 1.76(s, 3H), 1.81(s, 3H), 2.76(s, 3H), 3.23(s,



3H), 3.43(s, 3H), 3.72(s, 3H), 3.76(s, 3H), 4.64(d, J=6.6Hz, 2H),



5.50(t, J=6.6Hz, 1H), 6.78(s, 1H), 7.08(d, J=8.7Hz, 1H), 7.33–



7.51(m, 4H), 7.56–7.63(m, 1H), 7.96(d.d, J=7.5&1.2Hz, 1H)



IR(KBr)1725, 1609, 1520, 1480, 1400, 1366, 1295, 1260, 1178,



1119, 1073, 1010cm−1


I-653
1HNMR(CDCl3)δ 2.38(s, 3H), 2.72(s, 3H) 3.12(s, 3H), 3.43(s,



3H), 3.73(s, 3H), 3.76(s, 3H), 5.14(s, 2H), 6.79(s, 1H), 7.13–7.24



(m, 3H), 7.30–7.38(m, 3H), 7.41–7.51(m, 3H), 7.56–7.63(m, 1H),



795(d.d, J=7.5&1.2Hz, 1H)



IR(KBr)1725, 1610, 1520, 1481, 1401, 1370, 1293, 1262, 1179,



1119, 1076, 1011cm−1

















TABLE 129







I-654
1HNMR(CDCl3)δ 1.75(s, 3H), 1.81(s, 3H), 3.56(s, 3H), 3.72(s,



3H), 4.60(d, J=6.6Hz, 2H), 5.29(s, 1H), 5.46–5.56(m, 1H), 5.56–



6.00(broad, 1H), 6.42(s, 1H), 6.94(s, 2H), 7.05(s, 1H), 7.43–7.52



(m, 2H), 7.56–7.65(m, 1H), 7.99(.d, J=8.7Hz, 1H)



IR(KBr)3433, 1697, 1585, 1517, 1481, 1454, 1410, 1287, 1244,



1117, 1068cm−1


I-655
1HNMR(CDCl3)δ 2.39(s, 3H), 3.37(s, 3H), 3.72(s, 3H), 5.10(s,



2H), 6.41(s, 1H), 6.94(dd, J=8.1&2.1Hz, 1H), 7.02(d, J=8.1Hz,



1H), 7.06(d, J=2.1Hz, 1H), 7.23(d, J=7.8Hz, 2H), 7.35(.d, J=7.8



Hz, 2H), 7.42–7.63(m, 3H), 7.96(d, J=7.8Hz, 1H)



IR(KBr)3538, 3443, 1685, 1518, 1458, 1413, 1253, 1116, 1069,



1010cm−1


I-656
m.p. 110–112° C.



1HNMR(CDCl3)δ 1.69(s, 3H), 1.74(s, 3H), 2.55(q, J=7.1Hz, 2H),



3.20(s, 3H), 3.21(s, 3H), 3.39(s, 3H), 3.70(s, 3H), 4.07(t, J=7.1Hz,



2H), 5.22(t, J=7.1Hz, 1H), 6.28(s, 1H), 7.09(d, J=8.4Hz, 1H), 7.32



(dd, J=8.4, 2.0Hz, 1H), 7.36(d, J=8.9Hz, 2H), 7.37(d, J=2.0Hz,



1H), 7.69(d, J=8.9Hz, 2H)



IR(KBr)3477, 3402, 1607, 1518, 1481, 1365, 1151, 1111, 872,



813cm−1


I-657
m.p. 159–162° C.



1HNMR(DMSO-d6)δ 1.64(s, 3H), 1.71(s, 3H), 2.45(q, J=6.7Hz,



2H), 3.27(s, 3H), 3.59(s, 3H), 3.96(t, J=6.7Hz, 2H), 4.22(s, 2H),



5.26(t, J=6.7Hz, 1H), 6.17(s, 1H), 6.60(dd, J=8.1, 2.0Hz, 1H),



6.67(d, J=2.0Hz, 1H), 6.83(d, J=8.7Hz, 2H), 6.95(d, J=8.1Hz, 1H),



7.42(d, J=8.7Hz, 2H), 8.89(s, 1H), 9.46(s, 1H)



IR(KBr)3447, 3401, 3361, 1611, 1522, 1486, 1260, 1228, 1122,



1001, 814cm−1


I-658
m.p. 146–147° C.



1HNMR(CDCl3)δ 1.14(t, J=7.2Hz, 3H), 1.76(d, J=0.9Hz, 3H),



1.81(d, J=0.3Hz, 3H), 2.70(s, 3H), 3.20(s, 3H), 3.23(s, 3H), 3.72



(q, J=7.2Hz, 2H), 3.78(s, 3H), 4.64(d, J=6.6Hz, 2H), 5.49(m, 1H),



6.84(s, 1H), 7.09(d, J=8.4Hz, 1H), 7.31–7.41(m, 4H), 7.66–7.74



(m, 2H)



IR(CHCl3)2930, 1608, 1517, 1479, 1369, 1148, 1116, 1082, 969,



872cm−1


I-659
m.p. 174–175° C.



1HNMR(CDCl3)δ 1.14(t, J=6.9Hz, 3H), 2.37(s, 3H), 2.65(s, 3H),



3.12(s, 3H), 3.20(s, 3H), 3.72(q, J=6.9Hz, 2H), 3.77(s, 3H), 5.14



(s, 2H), 6.84(s, 1H), 7.15(d, J=8.4Hz, 1H), 7.18–7.42(m, 6H),



7.66–7.73(m, 2H)



IR(CHCl3)1517, 1479, 1369, 1268, 1148, 1117, 1082, 969,



872cm−1

















TABLE 130







I-660
m.p. 147.5–148° C.



1HNMR(CDCl3)δ 1.14(t, J=7.2Hz, 3H), 1.68(s, 3H), 1.74(d, J=0.9



Hz, 3H), 2.50–2.59(m, 2H), 2.72(s, 3H), 3.20(s, 3H), 3.22(s, 3H),



3.72(q, J=7.2Hz, 2H), 3.77(s, 3H), 4.07(d, J=6.9Hz, 2H), 5.21(m,



1H), 6.84(s, 1H), 7.07(d, J=8.7Hz, 1H), 7.31–7.42(m, 4H), 7.66–



7.74(m, 2H)



IR(CHCl3)2930, 1607, 1517, 1480, 1369, 1148, 1118, 1082, 1025,



969, 872cm−1


I-661
m.p. 154–157° C.



1HNMR(CDCl3)δ 1.15(t, J=7.2Hz, 3H), 1.76(s, 3H), 1.82(s, 3H),



3.60(q, J=7.2Hz, 2H), 3.75(s, 3H), 4.61(d, J=6.9Hz, 2H), 4.93(s,



1H), 5.53(m, 1H), 5.69(s, 1H), 5.96(s, 1H), 6.45(s, 1H), 6.80–6.98



(m, 4H), 7.07(m, 1H), 7.51–7.58(m, 2H)



IR(CHCl3)3592, 3528, 2976, 2934, 1611, 1521, 1488, 1460,



1384, 1286, 1243, 1169, 1112, 1068, 994, 885, 824cm−1


I-662
m.p. 130.5–133° C.



1HNMR(CDCl3)δ 1.15(t, J=7.2Hz, 3H), 2.39(s, 3H), 3.59(q, J=7.2



Hz, 2H), 3.74(s, 3H), 4.83(s, 1H), 5.10(s, 2H), 5.66(s, 1H), 5.97(s,



1H), 6.44(s, 1H), 6.87–6.94(m, 2H), 6.96(dd, J=1.8, 8.4Hz, 1H),



7.02(d, J=8.4Hz, 1H), 7.09(d, J=1.8Hz, 1H), 7.19–7.26(m, 2H),



7.30–7.38(m, 2H), 7.51–7.58(m, 2H)



IR(CHCl3)3524, 1612, 1521, 1488, 1460, 1383, 1286, 1246, 1113,



1069, 1027, 907, 873cm−1


I-663
amorphous powder



1HNMR(CDCl3)δ 1.15(t, J=7.2Hz, 3H), 1.68(d, J=0.6Hz, 3H),



1.74(d, J=0.9Hz, 3H), 2.48–2.56(m, 2H), 3.60(q, J=7.2Hz, 2H),



3.74(s, 3H), 4.06(d, J=6.9Hz, 2H), 4.95(s, 1H), 5.22(m, 1H), 5.68



(s, 1H), 5.96(s, 1H), 6.44(s, 1H), 6.88–6.99(m, 4H), 7.06(d, J=1.2



Hz, 1H), 7.51–7.58(m, 2H)



IR(CHCl3)3528, 2972, 1611, 1521, 1488, 1384, 1286, 1246, 1112,



1068, 1024, 883, 824cm−1


I-664
m.p. 113–116° C.



1HNMR(CDCl3)δ 2.55(s, 6H), 3.45(s, 3H), 3.74(s, 3H), 5.31(s,



2H), 6.44(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.94(dd, J=8.4, 2.1Hz,



1H), 7.10(s, 1H), 7.10(d, J=2.1Hz, 1H), 7.20(d, J=8.7Hz, 1H),



7.52(d, J=8.7Hz, 2H)



IR(Nujol)3491, 3443, 3304, 3155, 1662, 1608, 1523, 1492, 1464,



1251, 1215, 1111, 1067, 811, 782cm−1

















TABLE 131







I-665
m.p. >260° C.



1HNMR(CD3OD)δ 3.39(s, 3H), 3.68(s, 3H), 5.40(s, 2H), 6.44(s,



1H), 6.83(dd, J=8.4, 2.1Hz, 1H), 6.85(d, J=8.7, 2H), 6.90(d, J=2.1



Hz, 1H), 7.11(d, J=8.4Hz, 1H), 7.46(d, J=8.7Hz, 2H)



IR(Nujol)3350, 2668, 1611, 1595, 1530, 1488, 1458, 1402, 1253,



1213, 1116, 1073, 1016, 837, 817, 781cm−1


I-666
foam



1HNMR(CDCl3)δ 2.34(s, 3H), 2.44(s, 3H), 2.83(s, 3H), 3.12(s,



3H), 3.22(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 4.92(s, 2H), 6.85(s,



1H), 7.17(d, J=8.4Hz, 1H), 7.37~7.42(m, 2H), 7.39(d, J=8.7Hz,



2H), 7.68(d, J=8.7Hz, 2H)



IR(Nujol)1638, 1608, 1519, 1480, 1459, 1177, 1151, 1079, 971,



876, 844, 798cm−1


I-667
foam



1HNMR(CDCl3)δ 2.07(s, 3H), 2.53(s, 3H), 2.96(s, 3H), 3.23(s,



3H), 3.27(s, 3H), 3.54(s, 3H), 3.78(s, 3H), 4.86(s, 2H), 6.86(s,



1H), 7.11(d, J=9.0Hz, 1H), 7.33~7.41(m, 2H), 7.39(d, J=8.7Hz,



2H), 7.67(d, J=8.7Hz, 2H)



IR(Nujol)1724, 1688, 1610, 1520, 1481, 1464, 1234, 1177, 1151,



1123, 1081, 876, 798cm−1


I-668
m.p. 221–223° C.



1HNMR(DMSO-d6)δ 3.30(s, 3H), 3.64(s, 3H), 5.16(s, 2H), 6.39(s,



1H), 6.66(dd, J=8.4, 2.1Hz, 1H), 6.77(d, J=2.1Hz, 1H), 6.84(d,



J=8.7Hz, 2H), 7.00(d, J=8.4Hz, 1H), 7.34(s, 1H), 7.44(d, J=8.7



Hz, 2H), 8.43(s, 1H)



IR(Nujol)3535, 3411, 1611, 1582, 1521, 1488, 1463, 1244, 1194,



1135, 1119, 1074, 1014, 930, 826, 809cm−1


I-669
foam



1HNMR(CDCl3)δ 2.79(s, 3H), 3.17(s, 3H), 3.22(s, 3H), 3.55(s,



3H), 3.78(s, 3H), 5.21(s, 2H), 6.85(s, 1H), 7.19(d, J=8.4Hz, 1H),



7.23(s, 1H), 7.38(dd, J=8.7, 2.1Hz, 1H), 7.39(d, J=8.7Hz, 2H),



7.42(d, J=2.1Hz, 1H), 7.68(d, J=8.7Hz, 2H), 7.94(s, 1H)



IR(Nujol)1608, 1519, 1480, 1463, 1177, 1151, 1119, 1079, 971,



876, 798cm−1

















TABLE 132







I-670
m.p. 198–201° C.



1HNMR(DMSO-d6)δ 2.88(s, 3H), 3.39(s, 3H), 3.45(s, 3H), 3.52(s,



3H), 3.78(s, 3H), 4.58(s, 2H), 5.60(s, 1H), 7.07(s, 1H), 7.29(dd,



J=9.0, 1.8Hz, 1H), 7.30(d, J=1.8, Hz, 1H), 7.37(d, J=9.0Hz, 1H),



7.48(d, J=8.7Hz, 2H), 7.74(d, J=8.7Hz, 2H), 9.39(s, 1H)



IR(Nujol)3576, 3500, 3405, 3391, 1668, 1607, 1590, 1520, 1480,



1462, 1175, 1156, 1081, 1014, 880, 836, 826, 801cm−1


I-671
foam



1HNMR(CDCl3)δ 2.61(s, 3H), 2.73(s, 3H) 3.21(s, 3H), 3.23(s,



3H), 3.55(s, 3H), 3.78(s, 3H), 5.32(s, 2H), 6.84(s, 1H), 7.17(d, J=



8.4Hz, 1H), 7.36(dd, J=8.4, 2.1Hz, 1H), 7.38(d, J=8.7, Hz, 2H),



7.43(d, J=2.1Hz, 1H), 7.68(d, J=8.7Hz, 2H), 8.46(s, 1H), 8.75(s,



1H)



IR(Nujol)1608, 1519, 1481, 1463, 1177, 1151, 1080, 971, 876,



798cm−1


I-672
foam



1HNMR(CDCl3)δ 2.75(s, 3H), 3.21(s, 3H), 3.25(s, 3H), 3.55(s,



3H), 3.78(s, 3H), 5.37(s, 2H), 6.84(s, 1H), 7.17(d, J=8.4Hz,



1H), 7.36(dd, J=8.4, 2.1Hz, 1H), 7.38(d, J=8.7, Hz, 2H), 7.43(d,



J=2.1Hz, 1H), 7.68(d, J=8.7Hz, 2H), 8.59(s, 1H), 8.92(s, 1H)



IR(Nujol)1608, 1519, 1480, 1463, 1177, 1151, 1080, 971, 876,



798cm−1


I-673
foam



1HNMR(CDCl3)δ 2.70(s, 3H), 3.15(s, 3H), 3.21(s, 3H), 3.55



(s, 3H), 3.78(s, 3H), 5.14(s, 2H), 6.77(m, 2H), 6.84(s, 1H), 7.19



(m, 2H), 7.26(d, J=8.4Hz, 1H), 7.37(d, J=2.1Hz, 1H), 7.38(dd,



J=2.1, 8.4Hz, 1H), 7.68(d, J=8.4Hz, 2H)


I-674
m.p. 153–156° C.



1HNMR(CDCl3)δ 2.18(s, 3H), 2.81(s, 3H), 3.18(s, 3H), 3.22(s,



3H), 3.55(s, 3H), 3.79(s, 3H), 5.14(s, 2H), 6.86(s, 1H), 7.18(dd, J=



8.1, 8.1Hz, 1H), 7.24(d, J=8.1Hz, 1H), 7.26(d, J=8.4Hz, 1H), 7.36



(d, J=1.8Hz, 1H), 7.38(d, J=8.4Hz, 2H), 7.39(dd, J=1.8, 8.4Hz,



1H), 7.43(dd, J=8.1, 8.1Hz, 1H), 7.67(d, J=8.4Hz, 2H), 7.90(d, J=



8.1Hz, 1H)



IR(KBr)3384, 1689, 1519, 1481, 1364, 1177, 1151, 1079, 970,



874, 798cm−1

















TABLE 133







I-675
foam



1HNMR(CDCl3)δ 2.76(s, 3H), 3.16(s, 3H), 3.22(s, 3H), 3.23



(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 5.23(s, 2H), 6.85(s, 1H), 7.23



(dd, J=7.5, 7.5Hz, 1H), 7.37(s, 2H), 7.38(d, J=8.4Hz, 2H), 7.43(m,



3H), 7.54(d, J=7.5Hz, 1H), 7.68(d, J=8.4Hz, 2H)



IR(KBr)3435, 1609, 1519, 1481, 1364, 1177, 1152, 1079, 972,



876, 798cm−1


I-676
m.p. 163–165° C.



1HNMR(CDCl3)δ 2.78(s, 3H), 3.03(s, 3H), 3.21(s, 3H), 3.45(s,



6H), 3.55(s, 3H), 3.79(s, 3H), 5.31(s, 2H), 6.84(s, 1H), 7.22(d, J=



8.4Hz, 1H), 7.37(dd, J=2.4, 8.4Hz, 1H), 7.38(d, J=8.4Hz, 2H),



7.42(m, 2H), 7.53(m, 2H), 7.67(d, J=8.4Hz, 2H), 7.68(m, 1H)



IR(KBr)1609, 1519, 1481, 1365, 1176, 1161, 1080, 973, 875, 799



cm−1


I-677
m.p. 153–156° C.



1HNMR(CDCl3)δ 2.69(s, 3H), 2.98(s, 3H), 3.17(s, 3H), 3.21(s,



3H), 3.33(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 5.44(s, 2H), 6.84(s,



1H), 7.21(d, J=8.7Hz, 1H), 7.31–7.46(m, 5H), 7.38(d, J=8.4Hz,



2H), 7.68(d, J=8.4Hz, 2H), 7.72(m, 1H)



IR(KBr)1610, 1519, 1481, 1365, 1177, 1149, 1079, 963, 876,



799cm−1


I-678
foam



1HNMR(CDCl3)δ 2.60(s, 3H), 2.75(s, 6H), 3.17(s, 3H), 3.21



(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 5.31(s, 2H), 6.83(s, 1H), 7.08



(dd, J=7.5, 7.5Hz, 1H), 7.16(d, J=8.4Hz, 1H), 7.17(d, J=7.5Hz,



1H), 7.30(dd, J=2.1, 8.4Hz, 1H), 7.32(dd, J=7.5, 7.5Hz, 1H), 7.37



(d, J=8.4Hz, 2H), 7.38(d, J=2.1Hz, 1H), 7.52(d, J=7.5Hz, 1H),



7.68(d, J=8.4Hz, 2H)



IR(KBr)1609, 1519, 1480, 1365, 1235, 1177, 1151, 1079, 970,



874, 797cm−1


I-679
m.p. 95–97° C.



1HNMR(CDCl3)δ 1.76(s, 3H), 1.80(s, 3H), 3.03(s, 3H), 3.21(s,



3H), 3.56(s, 3H), 3.75(s, 3H), 4.63(d, J=6.9Hz, 2H), 4.93(s, 2H),



5.51(m, 1H), 6.66(s, 1H), 7.05(d, J=8.4Hz, 1H), 7.09–7.17(m,



2H), 7.37(dd, J=2.4, 8.4Hz, 1H), 7.44(d, J=2.4Hz, 1H), 7.51–7.58



(m, 2H)



IR(KBr)3435, 2936, 1605, 1519, 1475, 1382, 1365, 1232, 1161,



1109, 1080cm−1

















TABLE 134







I-680
m.p. 142–144° C.



1HNMR(CDCl3)δ 1.76(s, 3H), 1.81(s, 3H), 3.07(s, 3H), 3.57(s,



3H), 3.74(s, 3H), 4.61(d, J=6.6Hz, 2H), 4.90(s, 2H), 5.51(m, 1H),



5.65(s, 1H), 6.66(s, 1H), 6.92(m, 2H), 7.03(m, 1H), 7.09–7.17



(m, 2H), 7.52–7.58(m, 2H)



IR(KBr)3455, 2964, 2932, 1606, 1583, 1519, 1479, 1387, 1283,



1227, 1153, 1115, 1080, 1094, 1004cm−1


I-681
m.p. 158–160° C.



1HNMR(CDCl3)δ 1.76(s, 3H), 1.81(s, 3H), 3.20(s, 3H), 3.42(s,



3H), 3.76(s, 3H), 4.63(d, J=6.6Hz, 2H), 5.51(m, 1H), 6.04(s, 1H),



6.43(s, 1H), 7.07(d, J=8.4Hz, 1H), 7.11–7.19(m, 2H), 7.42(dd,



J=2.1, 8.4Hz, 1H), 7.50(d, J=2.1Hz, 1H), 7.58–7.65(m, 2H)



IR(KBr)3505, 3440, 1613, 1522, 1489, 1386, 1352, 1292, 1227,



1109, 1013cm−1


I-682
m.p. 175–178° C.



1HNMR(CDCl3)δ 1.63(s, 3H), 1.92–2.13(m, 4H), 3.22(s, 3H),



3.42(s, 3H), 3.76(s, 3H), 4.13(t, J=6.3Hz, 2H), 6.04(s, 1H), 6.44(s,



1H), 7.06(d, J=8.4Hz, 1H), 7.11–7.19(m, 2H), 7.43(dd, J=2.1, 8.4



Hz, 1H), 7.49(d, J=2.1Hz, 1H), 7.57–7.65(m, 2H)



IR(KBr)3467, 2973, 2943, 1613, 1523, 1489, 1359, 1232, 1113,



1072cm−1


I-683
powder



1HNMR(CDCl3)δ 1.69(s, 3H), 1.75(s, 3H), 2.48–2.57(m,



2H), 3.08(s, 3H), 3.57(s, 3H), 3.74(s, 3H), 4.06(t, J=6.9Hz, 2H),



4.90(s, 2H), 5.22(m, 1H), 5.64(s, 1H), 6.66(s, 1H), 6.91(m, 2H),



7.03(m, 1H), 7.08–7.17(m, 2H), 7.52–7.59(m, 2H)



IR(KBr)3432, 2930, 1604, 1583, 1518, 1475, 1382, 1280, 1249,



1222, 1160, 1111, 1082cm−1


I-684
m.p. 151–153° C.



1HNMR(CDCl3)δ 1.69(s, 3H), 1.73(s, 3H), 2.50–2.59(m, 2H),



3.19(s, 3H), 3.42(s, 3H), 3.76(s, 3H), 4.06(t, J=6.9Hz, 2H), 5.21



(m, 1H), 6.02(s, 1H), 6.43(s, 1H), 7.05(d, J=8.4Hz, 1H), 7.11–



7.19(m, 2H), 7.42(dd, J=2.4, 8.4Hz, 1H), 7.50(d, J=2.4Hz, 1H),



7.57–7.65(m, 2H)



IR(KBr)3457, 2937, 1613, 1523, 1489, 1465, 1390, 1361, 1295,



1234, 1185, 1110, 1072, 1013cm−1

















TABLE 135







I-685
m.p. 156–158° C.



1HNMR(CDCl3)δ 1.76(s, 3H), 1.81(s, 3H), 3.21(s, 3H), 3.42(s,



3H), 3.76(s, 3H), 4.54(d, J=6.9Hz, 2H), 5.52(t, J=6.9Hz, 1H), 6.94



(s, 1H), 6.94(d, J=8.7Hz, 2H), 7.29(d, J=8.7Hz, 2H), 7.37(d, J=8.7



Hz, 2H), 7.71(d, J=8.7Hz, 2H)



IR(KBr)1734, 1517, 1464, 1360, 1237, 1150, 1061, 988, 862cm−1


I-686
m.p. 189–191° C.



1HNMR(CDCl3)δ 3.21(s, 3H), 3.21(s, 3H), 3.42(s, 3H), 3.61(s,



3H), 3.76(s, 3H), 5.09(s, 2H), 6.94(s, 1H), 7.10(d, J=8.4Hz, 2H),



7.28–7.48(m, 9H), 7.71(d, J=8.4Hz, 2H)



IR(KBr)1727, 1518, 1469, 1365, 1239, 1152, 1061, 865cm−1


I-687
m.p. 112–113° C.



1HNMR(CDCl3)δ 1.68(s, 3H), 1.74(s, 3H), 2.50(q, J=7.2Hz, 2H),



3.21(s, 3H), 3.42(s, 3H), 3.62(s, 3H), 3.76(s, 3H), 3.96(t, J=7.2Hz,



2H), 5.23(t, J=7.2Hz, 1H), 6.92(d, J=8.8Hz, 2H), 6.93(s, 1H), 7.28



(d, J=8.8Hz, 2H), 7.37(d, J=8.8Hz, 2H), 7.71(d, J=8.8Hz, 2H)



IR(KBr)1735, 1519, 1469, 1361, 1246, 1153, 1059, 877, 861,



847, 791cm−1


I-688
m.p. 191–193° C.



1HNMR(DMSO-d6)δ 1.73(s, 3H), 1.76(s, 3H), 3.31(s, 3H), 3.71(s,



3H), 4.54(d, J=6.9Hz, 2H), 5.46(t, J=6.9Hz, 1H), (s, 1H), 6.87(d,



J=8.7Hz, 2H), 6.91(s, 1H), 6.92(d, J=8.7Hz, 2H), 7.19(d, J=8.7



Hz, 2H), 7.48(d, J=8.7Hz, 2H), 9.59(s, 1H), 12.8(brs, 1H)



IR(KBr)3462, 1695, 1609, 1520, 1472, 1231, 1177, 1062, 1001,



837cm−1


I-689
m.p. 229–232° C.



1HNMR(DMSO-d6)δ 3.31(s, 3H), 3.71(s, 3H), 5.12(s, 2H), 6.87(d,



J=8.8Hz, 2H), 6.98(s, 1H), 7.01(d, J=8.8Hz, 2H), 7.21(d, J=8.8



Hz, 2H), 7.34–7.50(m, 7H), 9.58(s, 1H), 12.8(brs, 1H)



IR(KBr)3424, 3238, 1685, 1610, 1521, 1464, 1379, 1235, 1180,



1057, 1001, 826cm−1

















TABLE 136







I-690
m.p. 171–172° C.



1HNMR(DMSO-d6)δ 1.64(s, 3H), 1.70(s, 3H), 2.43(q, J=6.9Hz,



2H), 3.31(s, 3H), 3.70(s, 3H), 3.96(t, J=6.9Hz, 2H), 5.23(t, J=6.9



Hz, 1H), 6.87(d, J=8.8Hz, 2H), 6.91(d, J=8.8Hz, 2H), 6.98(s, 1H),



7.19(d, J=8.8Hz, 2H), 7.48(d, J=8.8Hz, 2H), 9.58(s, 1H), 12.8(brs,



1H)



IR(KBr)3402, 3266, 1689, 1612, 1521, 1470, 1376, 1241, 1181,



1063, 1001, 829cm−1


I-691
mp 191–193° C.



1HNMR(CDCl3)δ 2.55(s, 3H), 3.52(s, 3H), 3.77(s, 3H), 5.17(s,



2H), 5.70(s, 1H), 6.83(s, 1H), 6.91(dd, J=1.8, 8.1Hz, 1H), 7.00–



7.05(m, 2H), 7.10–7.19(m, 2H), 7.34–7.45(m, 5H), 7.57–7.65(m,



2H)



IR(KBr)3030, 2934, 1606, 1523, 1487, 1391, 1358, 1290, 1228,



1077, 1019, 947, 831, 815, 803cm−1


I-692
mp 172–173° C.



1HNMR(CDCl3)δ 2.47(s, 3H), 3.52(s, 3H), 3.53(s, 3H), 3.77(s,



3H), 5.21(s, 2H), 5.25(s, 2H), 6.82(s, 1H), 7.01–7.03(m, 2H),



7.11–7.18(m, 2H), 7.22–7.41(m, 6H), 7.57–7.63(m, 2H)



IR(KBr)3010, 2931, 1602, 1519, 1484, 1385, 1369, 1232, 1174,



1085, 847, 806, 729, 527cm−1


I-693
mp 129–132° C.



1HNMR(CDCl3)δ 3.44(s, 3H), 3.53(s, 3H), 3.75(s, 3H), 5.20(s,



2H), 5.26(s, 2H), 5.91(s, 1H), 6.44(s, 1H), 7.01(d, J=8.1Hz, 1H),



7.08(dd, J=1.8Hz, 8.1Hz, 1H), 7.11–7.18(m, 2H), 7.28–7.50(m,



6H), 7.57–7.64(m, 2H)



IR(KBr)2996, 2952, 2932, 2895, 1609, 1522, 1488, 1229, 1120,



1075, 999, 911, 815, 724, 582cm−1


I-694
mp 124–126° C.



1HNMR(CDCl3)δ 1.76(d, J=0.6Hz, 3H), 1.80(d, J=0.9Hz, 3H),



2.69(2H, s), 3.54(s, 3H), 3.57(s, 3H), 3.76(s, 3H), 4.64(d, J=6.6



Hz, 2H), 5.26(s, 3H), 5.54(m, 1H), 6.86(s, 1H), 6.98(d, J=8.7Hz,



1H), 7.13–7.25(m, 3H), 7.38–7.43(m, 3H)



IR(CHCl3)2935, 2855, 1675, 1603, 1520, 1481, 1387, 1370, 1247,



1178, 1158, 1134, 1081, 1003, 961, 839, 814cm−1

















TABLE 137







I-695
mp 141–142° C.



1HNMR(CDCl3)δ 2.34(s, 3H), 2.48(s, 3H), 5.16(s, 2H), 5.70(s,



1H), 6.82(dd, J=8.4, 2.1Hz, 1H), 6.97–7.00(m, 2H), 7.07–7.13



(m, 4H), 7.32–7.46(m, 7H)



IR(CHCl3)3543, 3023, 2871, 1604, 1587, 1520, 1489, 1469, 1383,



1267, 1243, 1158, 1126, 1014, 957, 877, 839cm−1


I-696
mp 178–180° C.



1HNMR(CDCl3)δ 2.75(s, 3H), 3.18(s, 3H), 3.55(s, 3H), 3.76(s,



3H), 5.18(s, 2H), 5.72(s, 1H), 6.87(s, 1H), 7.00(d, J=8.7Hz, 1H),



7.15(dd, J=8.7, 2.1Hz, 1H), 7.24–7.28(m, 2H), 7.36–7.50(m, 8H)



IR(CHCl3)3543, 3027, 2939, 1519, 1481, 1371, 1330, 1254, 1204,



1177, 1150, 1082, 1005, 969, 873cm−1


I-697
mp 129–130° C.



1HNMR(CDCl3)δ 2.24(s, 3H), 2.29(s, 3H), 3.12(s, 3H), 5.18(s,



2H), 7.08–7.14(m, 5H), 7.25–7.50(m, 9H)



IR(CHCl3)2925, 2871, 1604, 1520, 1490, 1455, 1369, 1291, 1262,



1169, 1111, 1007, 972, 957, 882, 840, 816cm−1


I-698
mp 124–125° C.



1HNMR(CDCl3)δ 1.77(s, 3H), 1.81–1.82(d, J=0.9Hz, 3H), 2.24(s,



3H), 2.28(s, 3H), 3.22(s, 3H), 4.63(d, J=6.6Hz, 2H), 5.52(m, 1H),



7.04–7.14(m, 5H), 7.24–7.34(m, 4H)



IR(KBr)2978, 2924, 2868, 1893, 1771, 1604, 1520, 1489, 1368,



1290, 1261, 1169, 1109, 1046, 973, 957, 882, 740, 816cm−1


I-699
oil



1HNMR(CDCl3)δ 1.69(s, 3H), 1.74–1.75(d, J=0.9Hz, 3H), 2.24



(s, 3H), 2.28(s, 3H), 2.55(m, 2H), 3.21(s, 3H), 4.05–4.10(t, J=



6.9Hz, 2H) 5.22(m, 1H), 7.03–7.14(m, 5H), 7.24–7.34(m, 4H)



IR(CHCl3)2970, 2926, 2875, 1605, 1520, 1490, 1470, 1368,



1292, 1277, 1169, 1110, 1016, 973, 958, 878, 840, 819cm−1


I-700
mp 121–123° C.



1HNMR(CDCl3)δ 2.24(s, 3H), 2.83(s, 3H), 2.98(s, 3H), 3.11(s,



3H), 5.13(s, 2H), 7.08–7.14(m, 4H), 7.21–7.37(m, 9H)



IR(CHCl3)2925, 1605, 1520, 1489, 1369, 1262, 1169, 1014,



1003, 972, 957, 882, 840, 816cm−1

















TABLE 138







I-701
mp 215–217° C.



1H NMR(CDCl3)δ 2.73(s, 3H), 3.13(s, 3H), 3.18(s, 3H), 3.57(s,



3H), 3.78(s, 3H), 5.20(s, 2H), 6.86(s, 1H), 7.16(d, J=8.7Hz, 1H),



7.35–7.50(m, 9H), 7.56(dd, J=8.4, 2.4Hz, 1H), 7.62(d, J=2.4Hz,



1H)



IR(CHCl3)2939, 1613, 1519, 1480, 1371, 1294, 1254, 1176,



1150, 1119, 1083, 1003, 970, 871, 849, 816cm−1


I-702
mp 71–73° C.



1H NMR(CDCl3)δ 1.77(s, 3H), 1.83(s, 3H), 2.24(s, 3H), 2.29(s,



3H), 4.61–4.64(d, J=6.9Hz, 2H), 5.54(m, 1H), 5.71(s, 1H), 6.80–



6.84(dd, J=8.4, 2.1Hz, 1H), 6.92(d, J=8.4Hz, 1H), 7.07–7.13(m,



4H), 7.30–7.35(m, 2H)



IR(KBr)3537, 2977, 2924, 2868, 1604, 1585, 1520, 1489, 1450,



1386, 1292, 1267, 1242, 1158, 1125, 996, 957, 839cm−1


I-703
oil



1H NMR(CDCl3)δ 1.69(s, 3H), 1.75–1.76(d, J=0.9Hz, 3H), 2.24(s,



3H), 2.28(s, 3H), 2.50–2.57(td, J=6.9, 6.3Hz, 2H), 4.05–4.10(t,



J=6.3Hz, 2H), 5.24(m, 1H), 5.70(s, 1H), 6.81(dd, J=8.4, 1.8Hz,



1H), 6.90(d, J=8.4Hz, 1H), 6.96(d, J=1.8Hz, 1H), 7.06–7.13(m,



4H), 7.26–7.34(m, 2H)



IR(CHCl3)3540, 2972, 2925, 2877, 1604, 1585, 1520, 1490,



1387, 1293, 1267, 1245, 1158, 1127, 1016, 957, 839cm−1


I-704
mp 113–115° C.



1H NMR(CDCl3)δ 2.24(s, 3H), 2.28(s, 3H), 2.39(s, 3H), 5.11(s,



2H), 5.69(s, 1H), 6.82(dd, J=8.4, 2.4Hz, 1H), 6.97–7.00(m, 2H),



7.07–7.13(m, 3H), 7.22–7.36(m, 7H)



IR(CHCl3)3541, 2925, 2871, 1604, 1586, 1520, 1490, 1469,



1380, 1324, 1308, 1292, 1267, 1243, 1201, 1158, 1126, 1013, 957,



876, 839cm−1

















TABLE 139







I-705
foam



1H NMR(CDCl3)δ 3.20(s, 3H), 3.27(s, 3H), 3.43(s, 3H), 3.73(s,



3H), 4.37(br d, J=5.7Hz, 2H), 4.58(s, 2H), 5.16(s, 2H), 5.68(s,



1H), 6.82(dd, J=8.2, 1.7Hz, 1H), 6.88(s, 1H), 6.97(d, J=1.7Hz,



1H), 6.98(d, J=8.2Hz, 1H), 7.35–7.47(m, 7H), 7.71(d, J=8.7Hz,



2H)



IR(KBr)3464, 1515, 1474, 1369, 1230, 1199, 1176, 1149, 1039,



873cm−1


I-706
foam



1H NMR(CDCl3)δ 2.42(br s, 1H), 3.12(s, 3H), 3.22(s, 3H), 3.45(s,



3H), 3.74(s, 3H), 4.49(br s, 1H), 5.18(s, 2H), 6.85(s, 1H), 7.15(d,



J=8.6Hz, 1H), 7.27(dd, J=8.6, 2.0Hz, 1H), 7.35–7.50(m, 8H), 7.71



(d, J=8.6Hz, 2H)



IR(KBr)3583, 3435, 1519, 1467, 1412, 1229, 1180, 1150, 1022,



875, 849, 798, 742, 706cm−1


I-707
mp 120–121° C.



1H NMR(CDCl3)δ 3.45(s, 3H), 3.45(s, 3H), 3.75(s, 3H), 4.66(s,



2H), 4.77(s, 2H), 5.15(s, 2H), 5.67(s, 1H), 5.91(s, 1H), 6.47(s,



1H), 6.96(dd, J=8.4, 1.9Hz, 1H), 7.03(d, J=8.4Hz, 1H), 7.09(d, J=



1.9Hz, 1H), 7.37–7.47(m, 7H), 7.64(d, J=8.4Hz, 2H)



IR(KBr)3504, 3461, 1522, 1485, 1466, 1384, 1466, 1384, 1283,



1245, 1197, 1110, 1042, 925, 812, 749cm−1


I-708
mp 156–158° C.



1H NMR(CDCl3)δ 3.11(s, 3H), 3.21(s, 3H), 3.28(s, 3H), 3.42(s,



3H), 3.73(s, 3H), 4.38(s, 2H), 4.58(s, 2H), 5.18(s, 2H), 6.88(s,



1H), 7.12(d, J=8.7Hz, 1H), 7.27(dd, J=8.7, 2.1Hz, 1H), 7.35–7.50



(m, 8H), 7.70(d, J=8.7Hz, 2H)



IR(KBr)1514, 1469, 1360, 1177, 1149, 1099, 1042, 870cm−1


I-709
mp 188–190° C.



1H NMR(CDCl3)δ 1.70(t, J=5.7Hz, 1H), 3.45(s, 3H), 3.75(s, 3H),



4.77(d, J=5.7Hz, 2H), 5.16(s, 2H), 5.68(s, 1H), 5.91(s, 1H), 6.47



(s, 1H), 6.96(dd, J=8.5, 1.7Hz, 1H), 7.03(d, J=8.5Hz, 1H), 7.09(d,



J=1.7Hz, 1H), 7.37–7.48(m, 7H), 7.65(d, J=8.4Hz, 2H)



IR(KBr)3547, 3492, 3451, 1521, 1487, 1385, 1288, 1249, 1209,



1108, 1011, 746, 702cm−1

















TABLE 140







I-710
mp 178–180° C.



1H NMR(CDCl3)δ 2.43(br s, 1H), 3.44(s, 3H), 3.72(s, 3H), 4.52



(m, 2H), 4.93(s, 1H), 5.15(s, 2H), 5.70(s, 1H), 6.79(dd, J=8.1,



2.1Hz, 1H), 6.84(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.93(d, J=2.1Hz,



1H), 7.00(d, J=8.7Hz, 1H), 7.38–7.48(m, 5H), 7.54(d, J=9.0Hz,



2H)



IR(KBr)3447, 3214, 1609, 1518, 1477, 1459, 1391, 1260, 1221,



1008, 984, 833, 799, 751cm−1


I-711
foam



1H NMR(CDCl3)δ 2.85(s, 3H), 3.22(s, 3H), 3.30(s, 3H), 3.54(s,



3H), 3.78(s, 3H), 5.02(s, 2H), 6.85(s, 1H), 7.08(d, J=8.4Hz, 1H),



7.32(d, J=2.1Hz, 1H), 7.37(dd, J=8.4, 2.1Hz, 1H), 7.39(d, J=8.7



Hz, 2H), 7.67(d, J=8.7Hz, 2H)



IR(Nujol)3423, 3320, 3215, 1610, 1519, 1480, 1454, 1176, 1151,



1080, 969, 876, 798cm−1


I-712
foam



1H NMR(CDCl3)δ 2.62(s, 3H), 3.45(s, 3H), 3.74(s, 3H), 5.28(s,



2H), 6.45(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.95(dd, J=8.4, 2.1Hz,



1H), 7.10(d, J=8.4Hz, 1H), 7.11(d, J=2.1Hz, 1H), 7.53(d, J=8.7



Hz, 2H), 8.50(brs, 1H), 8.60(brs, 1H)



IR(Nujol)3207, 1611, 1589, 1523, 1489, 1460, 1227, 1116, 1072,



1014, 943, 822, 759cm−1


I-713
mp 231–233° C.



1H NMR(CDCl3)δ 3.30(s, 3H), 3.64(s, 3H), 5.28(s, 2H), 6.39(s,



1H), 6.67(dd, J=8.4, 2.1Hz, 1H), 6.80(d, J=2.1Hz, 1H), 6.84(d,



J=8.7Hz, 2H), 7.01(d, J=8.4Hz, 1H), 7.44(d, J=8.7Hz, 2H), 8.64(d,



J=2.4Hz, 1H), 8.67(dd, J=2.4, 1.2Hz, 1H), 8.94(d, J=1.2Hz, 1H)



IR(Nujol)3369, 3164, 1612, 1600, 1585, 1522, 1493, 1385, 1255,



1118, 1073, 1013, 934, 824, 798, 778cm−1


I-714
foam



1H NMR(CDCl3)δ 2.83(s, 3H), 3.22(s, 3H), 3.27(s, 3H), 3.55(s,



3H), 3.78(s, 3H), 5.18(s, 2H), 6.85(s, 1H), 7.20(d, J=8.4Hz, 1H),



7.39(d, J=8.7Hz, 2H), 7.40(dd, J=8.4, 2.1Hz, 1H), 7.45(d, J=2.1



Hz, 1H), 7.67(d, J=8.7Hz, 2H)



IR(Nujol)3264, 1650, 1607, 1517, 1480, 1175, 1150, 1078, 946,



876, 798cm−1

















TABLE 141







I-715
foam



1H NMR(CDCl3)δ 2.76(s, 3H), 2.77(s, 3H), 3.21(s, 3H), 3.24(s,



3H), 3.55(s, 3H), 3.78(s, 3H), 5.35(s, 2H), 6.84(s, 1H), 7.25(d, J=



8.4Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.38(dd, J=8.4, 2.1Hz, 1H),



7.44(d, J=2.1Hz, 1H), 7.68(d, J=8.7Hz, 2H)



IR(Nujol)1607, 1578, 1519, 1465, 1176, 1151, 1079, 971, 947,



876, 846, 797cm−1


I-716
mp 227–229° C.



1H NMR(DMSO-d6)δ 2.87(s, 3H), 3.39(s, 3H), 3.45(s, 3H), 3.52



(s, 3H), 3.79(s, 3H), 5.23(s, 2H), 7.08(s, 1H), 7.33(d, J=2.1Hz,



1H), 7.35(dd, J=8.4, 2.1Hz, 1H), 7.44(d, J=8.4Hz, 1H), 7.49(d,



J=8.7Hz, 2H), 7.74(d, J=8.7Hz, 2H)



IR(Nujol)3276, 1651, 1605, 1520, 1480, 1463, 1174, 1150, 1079,



947, 879, 798cm−1


I-717
m.p 180–181° C.



1H NMR(CDCl3)δ 3.07(s, 3H), 3.45(s, 3H), 3.75(s, 3H), 5.18(s,



2H), 6.45(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.99(dd, J=1.8, 8.4Hz,



1H), 7.08(d, J=1.8Hz, 1H), 7.10(d, J=8.4Hz, 1H), 7.25(t, J=7.2Hz,



1H), 7.44(m, 2H), 7.53(d, J=8.7Hz, 2H), 7.61(d, J=8.1Hz, 1H)


I-718
foam



1H NMR(CDCl3)δ 3.06(s, 3H), 3.45(s, 3H), 3.74(s, 3H), 5.17(s,



2H), 6.45(s, 1H), 6.93(d, J=8.7Hz, 2H), 6.98(dd, J=8.7Hz, 1H),



7.08(d, J=2.1Hz, 1H), 7.10(d, J=8.4Hz, 1H), 7.24(m, 1H), 7.43



(m, 2H), 7.51(d, J=8.7Hz, 2H), 7.61(m, 1H)



IR(KBr)3430, 1611, 1590, 1523, 1490, 1402, 1323, 1242, 1149,



1112, 1070, 1010, 971, 826cm−1


I-719
foam



1H NMR(CDCl3)δ 2.80(s, 6H), 3.47(s, 3H), 3.76(s, 3H), 5.08(s



2H), 6.46(s, 1H), 6.92(d, J=8.7Hz, 3H), 7.10(d, J=2.1Hz, 1H),



7.15(d, J=8.7Hz, 1H), 7.20(d, J=7.2Hz, 1H), 7.34–7.45(m, 3H),



7.55(d, J=8.7Hz, 2H)



IR(KBr)3427, 1611, 1585, 1522, 1488, 1404, 1224, 1113, 1069,



1011, 940, 824, 767cm−1

















TABLE 142







I-720
foam



1H NMR(CDCl3)δ 1.52(s, 9H), 2.67(s, 3H), 3.19(s, 3H), 3.21(s,



3H), 3.56(s, 3H), 3.78(s, 3H), 5.17(s, 2H), 6.54(br.s, 1H), 7.11(m,



1H), 7.12(d, J=9.0Hz, 1H), 7.25(m, 1H), 7.30(d, J=7.5Hz, 1H),



7.32(dd, J=1.8, 9.0Hz, 1H), 7.36(d, J=8.7Hz, 2H), 7.41(d, J=1.8



Hz, 1H), 7.60(s, 1H), 7.67(d, J=8.7Hz, 2H)



IR(KBr)1724, 1610, 1520, 1481, 1366, 1234, 1177, 1153, 1079,



969, 875, 797cm−1


I-721
m.p 187–191° C.



1H NMR(CDCl3)δ 2.66(s, 3H), 3.17(s, 3H), 3.21(s, 3H), 3.55(s,



3H), 3.78(s, 3H), 5.11(s, 2H), 6.65(d, J=8.4Hz, 1H), 6.81(m, 2H),



6.84(s, 1H), 7.12(d, J=8.7Hz, 1H), 7.17(t, J=8.7Hz, 1H), 7.32(dd,



J=2.1, 8.7Hz, 1H), 7.37(d, J=8.7Hz, 2H), 7.40(d, J=2.1Hz, 1H),



7.67(d, J=8.7Hz, 2H)



IR(KBr)1624, 1606, 1519, 1481, 1361, 1176, 1148, 1081, 980,



876, 780cm−1


I-722
m.p 143–146° C.



1H NMR(CDCl3)δ 2.18(s, 3H), 2.71(s, 3H), 3.18(s, 3H), 3.21(s,



3H), 3.55(s, 3H), 3.78(s, 3H), 5.18(s, 2H), 6.84(s, 1H), 7.12(d, J=



8.7Hz, 1H), 7.17(d, J=7.2Hz, 1H), 7.33(m, 2H), 7.37(d, J=8.7Hz,



2H), 7.41(d, J=2.1Hz, 1H), 7.45(d, J=7.2Hz, 1H), 7.67(d, J=8.7Hz,



2H), 7.67(m, 1H)



IR(KBr)1693, 1609, 1519, 1481, 1364, 1364, 1173, 1149, 1079,



874, 802cm−1


I-723
foam



1H NMR(CDCl3)δ 2.86(s, 3H), 3.00(s, 3H), 3.22(s, 3H), 3.55(s,



3H), 3.78(s, 3H), 5.22(s, 2H), 6.59(s, 1H), 6.85(s, 1H), 7.10(d, J=



8.4Hz, 1H), 7.25(m, 3H), 7.32(d, J=2.1, 8.7Hz, 1H), 7.37(m, 1H),



7.38(d, J=2.1Hz, 1H), 7.38(d, J=8.7Hz, 1H), 7.67(d, J=8.7Hz, 2H)



IR(KBr)1610, 1519, 1480, 1364, 1176, 1150, 1079, 971, 876, 797



cm−1

















TABLE 143







I-724
foam



1H NMR(CDCl3)δ 2.74(s, 3H), 3.18(s, 3H), 3.21(s, 3H), 3.43(s,



6H), 3.55(s, 3H), 3.78(s, 3H), 5.24(s, 2H), 6.84(s, 1H), 7.13(d, J=



8.4Hz, 1H), 7.36(dt, J=2.1, 8.4Hz, 1H), 7.37(m, 1H), 7.39(d, J=8.7



Hz, 2H), 7.40(d, J=2.1Hz, 1H), 7.51(m, 2H), 7.61(s, 1H), 7.67(d,



J=8.7Hz, 2H)



IR(KBr)1609, 1523, 1481, 1353, 1176, 1161, 1080, 890, 799cm−1


I-725
m.p 147–150° C.



1H NMR(CDCl3)δ 2.79(s, 3H), 2.83(s, 3H), 3.20(s, 3H), 3.21(s,



3H), 3.35(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 5.22(s, 2H), 6.85(s,



1H), 7.11(d, J=8.7Hz, 1H), 7.32–7.46(m, 7H), 7.62(s, 1H), 7.67(d,



J=8.4Hz, 2H)



IR(KBr)1608, 1518, 1480, 1364, 1178, 1153, 1077, 968, 795cm−1


I-726
m.p 224–226° C.



1H NMR(CDCl3)δ 2.85(s, 3H), 2.91(s, 6H), 3.36(s, 3H), 3.45(s,



3H), 3.51(s, 3H), 3.78(s, 3H), 5.19(s, 2H), 6.69(d, J=8.1Hz, 1H),



6.76(d, J=8.1Hz, 1H), 6.89(s, 1H), 7.07(s, 1H), 7.20(t, J=8.1Hz,



1H), 7.30(m, 3H), 7.48(d, J=8.7Hz, 2H), 7.74(d, J=8.7Hz, 2H)



IR(KBr)1608, 1519, 1480, 1360, 1178, 1146, 1081, 879, 826cm−1


I-727
foam



1H NMR(CDCl3)δ 2.82(s, 3H), 3.18(s, 6H), 3.21(s, 3H), 3.53(s,



3H), 3.76(s, 3H), 5.17(s, 2H), 6.84(s, 1H), 7.11(d, J=8.4Hz, 1H),



7.20(s, J=4.8Hz, 1H), 7.30–7.47(m, 8H), 7.76(d, J=8.7Hz, 2H)



IR(KBr)3430, 1677, 1609, 1519, 1481, 1364, 1202, 1177, 1150,



1079, 876, 799cm−1


I-728
foam



1H NMR(CDCl3)δ 3.45(s, 3H), 3.75(s, 3H), 5.06(s, 2H), 6.45(s,



1H), 6.68(d, J=7.5Hz, 1H), 6.77(s, 1H), 6.82(d, J=7.5Hz, 1H),



6.91(d, J=8.7Hz, 2H), 6.93(dd, J=1.8, 8.4Hz, 1H), 6.99(d, J=8.4



Hz, 1H), 7.07(d, J=1.8Hz, 1H), 7.19(t, J=7.5Hz, 1H), 7.54(d, J=



8.7Hz, 2H)



IR(KBr)3413, 1611, 1522, 1488, 1461, 1405, 1251, 1119, 1076,



1007, 813, 784cm−1

















TABLE 144







I-729
m.p 90–93° C.



1H NMR(CDCl3)δ 3.01(s, 3H), 3.45(s, 3H), 3.75(s, 3H), 5.16(s,



2H), 6.45(s, 1H), 6.81(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.95(d, J=1.8



Hz, 1H), 6.96(m, 2H), 7.24(m, 2H), 7.40(t, J=7.2Hz, 1H), 7.52(d,



J=8.7Hz, 2H)



IR(KBr)3434, 1612, 1592, 1523, 1489, 1325, 1248, 1224, 1147,



1113, 1070, 1010, 972cm−1


I-730
mp 79–81° C.



1H NMR(CDCl3)δ 2.34(s, 6H), 3.48(s, 3H), 3.76(s, 3H), 4.72(brs,



1H), 5.16(s, 2H), 5.68(brs, 1H), 5.93(brs, 1H), 6.44(s, 1H), 6.99–



7.10(m, 3H), 7.26–7.49(m, 7H)



IR(KBr)3467, 2933, 1613, 1701, 1517, 1482, 1454, 1424, 1389,



1321, 1196, 1148, 1113, 1073cm−1


I-731
mp 189–191° C.



1H NMR(CDCl3)δ 3.20(s, 3H), 3.81(s, 6H), 5.14(s, 2H), 5.65(brs,



1H), 6.79(s, 2H), 6.79–7.02(m, 5H), 7.36–7.46(m, 6H), 7.66(d, J=



8.6Hz, 2H)



IR(KBr)3439, 2937, 1594, 1567, 1523, 1487, 1351, 1240, 1202,



1146, 1126, 874cm−1


I-732
mp 196–197° C.



1H NMR(DMSO-d6)δ 3.32(s, 3H), 3.43(s, 6H), 3.79(s, 6H), 5.24



(s, 2H), 7.00(s, 2H), 7.23–7.30(m, 3H), 7.35–7.55(m, 7H), 7.88(d,



J=8.4Hz, 2H)



IR(KBr)3434, 1602, 1561, 1523, 1485, 1362, 1288, 1238, 1201,



1181, 1148, 1126, 1115, 966, 914, 813cm−1


I-733
mp 202–203° C.



1H NMR(DMSO-d6)δ 2.40(s, 6H), 3.31(s, 3H), 3.34(s, 3H), 3.51



(s, 3H), 3.58(s, 3H), 3.77(s, 3H), 5.27(s, 2H), 7.03(s, 1H), 7.32–



7.530(m, 10H)



IR(KBr)3434, 3028, 2944, 1515, 1475, 1463, 1361, 1290, 1272,



1247, 1179, 1085, 967, 815, 804cm−1

















TABLE 145







I-734
mp 140–141° C.



1H NMR(CDCl3)δ 1.77(s, 3H), 1.82(s, 3H), 3.21(s, 3H), 3.83(s,



6H), 4.63(d, J=4.6Hz, 2H), 5.52–5.53(m, 1H), 6.79(s, 2H), 7.05(d,



J=8.8Hz, 1H), 7.29–7.42(m, 4H), 7.67(d, J=8.6Hz, 2H)



IR(KBr)3434, 2936, 1602, 1565, 1487, 1365, 1242, 1182, 1152,



1123, 1113, 974, 874, 811cm−1


I-735
mp 168–169° C.



1H NMR(CDCl3)δ 2.38(s, 3H), 3.09(s, 3H), 3.20(s, 3H), 3.81(s,



6H), 5.11(s, 2H), 6.78(s, 2H), 7.13–7.42(m, 9H), 7.66(d, J=8.8Hz,



2H)



IR(KBr)3433, 1601, 1566, 1486, 1367, 1246, 1182, 1153, 1114,



973, 869, 824cm−1


I-736
mp 192–194° C.



1H NMR(CDCl3)δ 1.77(s, 3H), 1.82(s, 3H), 2.47(s, 6H), 2.72(s,



3H), 3.24(s, 3H), 3.36(s, 3H), 3.57(s, 3H), 3.79(s, 3H), 4.64(d, J=



6.6Hz, 2H), 5.47–5.55(m, 1H), 6.83(s, 1H), 7.09(d, J=9.0Hz,



1H), 7.33–7.40(m, 4H)



IR(KBr)3435, 1942, 1516, 1474, 1382, 1357, 1288, 1178, 1096,



966, 862, 805cm−1


I-737
mp 224–225° C.



1H NMR(CDCl3)δ 2.38(s, 3H), 2.46(s, 6H), 2.66(s, 3H), 3.12(s,



3H), 3.35(s, 3H), 3.55(s, 3H), 3.77(s, 3H), 5.14(s, 2H), 6.82(s,



1H), 712–7.40(m, 9H)



IR(KBr)3435, 2941, 1518, 1474, 1360, 1274, 1179, 1095, 1085,



967, 862, 815, 805cm−


I-738
mp 203–204° C.



1H NMR(CDCl3)δ 1.76(s, 3H), 1.82(s. 3H), 2.46(s, 6H), 2.45–



2.58(m, 2H), 2.73(s, 3H), 3.22(s, 3H), 3.35(s, 3H), 3.55(s, 3H),



3.77(s, 3H), 4.07(d, J=6.6Hz, 2H), 5.18–5.25(m, 1H), 6.82(s, 1H),



7.07(d, J=8.2Hz, 1H), 7.32–7.39(m, 4H)



IR(KBr)3434, 2941, 1519, 1473, 1359, 1276, 1178, 1114, 1085,



967, 860, 811cm−1

















TABLE 146







I-739
mp 158–159° C.



1H NMR(DMSO-d6)δ 1.72(s, 3H), 1.76(s, 3H), 3.72(s, 6H), 4.54



(d, J=6.0Hz, 2H), 5.45–5.52(m, 1H), 6.55–6.59(m, 2H), 6.84–6.90



(m, 5H), 7.57(d, J=8.2Hz, 2H), 8.70(brs, 1H), 9.53(brs, 1H)



IR(KBr)3465, 2932, 1610, 1523, 1487, 1460, 1283, 1281, 1123,



1010, 819cm−1


I-740
mp 180–181° C.



1H NMR(CDCl3)δ 2.32(s, 3H), 3.72(s, 6H), 5.08(s, 2H), 6.54–



6.58(m, 1H), 6.68(s, 1H), 6.85–6.95(m, 5H), 7.21(d, J=7.6Hz,



2H), 7.39(d, J=7.8Hz, 2H), 7.57(d, J=8.4Hz, 2H), 8.83(brs, 1H),



9.54(brs, 1H)



IR(KBr)3519, 2937, 1607, 1562, 1523, 1461, 1400, 1246, 1176,



1125, 1003, 821cm−1


I-741
mp 105–106° C.



1H NMR(CDCl3)δ 2.13(s, 6H), 3.17(s, 3H), 5.16(s, 2H), 5.85(brs,



1H), 6.61–6.66(m, 1H), 6.77(s, 1H), 7.01(d, J=8.2Hz, 1H), 7.25–



7.46(m, 9H), 7.65(d, J=8.8Hz, 2H)



IR(KBr)3466, 3031, 2934, 1585, 1513, 1476, 1366, 1285, 1198,



1175, 1148, 1127, 1014, 968, 868, 840cm−1


I-742
mp 92–93° C.



1H NMR(DMSO-d6)δ 1.74(s, 3H), 1.78(s, 3H), 2.24(s, 6H), 3.31



(s, 3H), 3.65(s, 3H), 4.56(d, J=6.8Hz, 2H), 5.52(t, J=6.0Hz, 1H),



6.37(s, 1H), 6.64–6.76(m, 2H), 6.88–6.93(m, 1H), 7.16–7.20(m,



2H), 8.31(brs, 1H), 8.45(brs, 1H), 8.73(brs, 1H)



IR(KBr)3443, 2932, 1707, 1613, 1516, 1484, 1462, 1387, 1280,



1243, 1196, 1114, 1074, 979cm−1


I-743
mp 180–181° C.



1H NMR(DMSO-d6)δ 2.22(s, 6H), 2.32(s, 3H), 3.29(s, 3H), 3.63



(s, 3H), 5.08(s, 2H), 6.61–6.65(m, 1H), 6.75(s, 1H), 6.93(d, J=8.2



Hz, 1H), 7.13–7.22(m, 4H), 7.39(d, J=7.4Hz, 2H), 8.30(brs, 1H),



8.44(brs, 1H), 8.84(brs, 1H)



IR(KBr)3443, 2930, 1686, 1614, 1587, 1518, 14863, 1462, 1385,



1281, 1246, 1197, 1113, 1073, 1009, 806cm−1

















TABLE 147







I-744
mp 123–124° C.



1H NMR(DMSO-d6)δ 1.65(s, 3H), 1.71(s, 3H), 2.23(s, 6H), 2.36–



2.51(m, 2H), 3.31(s, 3H), 3.64(s, 3H), 3.91–3.98(m, 2H), 5.22–



5.28(m, 1H), 6.36(s, 1H), 6.65–6.88(m, 3H), 7.16(s, 1H), 8.30(brs,



1H), 8.44(brs, 1H), 8.70(brs, 1H)



IR(KBr)3444, 2930, 1686, 1613, 1518, 1483, 1390, 1283, 1248,



1198, 1113, 1074, 1013cm−1


I-745
mp 174–177° C.



1H NMR(CDCl3)δ 1.77–1.78(d, J=0.9Hz, 3H), 1.82–1.83(d, J=



0.9Hz, 3H), 2.74(s, 3H), 3.18(s, 3H), 3.25(s, 3H), 3.57(s, 3H),



3.78(s, 2H), 4.64–4.67(d, J=6.9Hz, 2H), 5.51(m, 1H), 6.86(s, 1H),



7.09(d, J=8.4Hz, 1H), 7.35–7.40(m, 2H), 7.45–7.49(m, 2H), 7.55–



7.60(m, 2H)



IR(CHCl3)2939, 1613, 1519, 1480, 1371, 1331, 1292, 1251, 1176,



1150, 1118, 1082, 971, 871, 849cm−1


I-746
mp 134–136° C.



1H NMR(CDCl3)δ 1.69(s, 3H), 1.75(s, 3H), 2.53–2.60(dt, J=6.6,



5.7Hz, 2H), 2.73(s, 3H), 3.18(s, 3H), 3.23(s, 3H), 3.56(s, 3H),



3.78(s, 3H), 4.07–4.11(t, J=5.7Hz, 2H), 5.22(m, 1H), 6.86(s, 1H),



7.07(d, J=9.0Hz, 1H), 7.35–7.40(m, 2H), 7.45–7.49(m, 2H), 7.55–



7.61(m, 2H)



IR(CHCl3)2938, 1614, 1519, 1480, 1448, 1371, 1331, 1294, 1228,



1176, 1150, 1119, 1083, 1004, 970, 870, 849, 819cm−1


I-747
mp 182–183° C.



1H NMR(CDCl3)δ 2.26(s, 3H), 2.28(s, 3H), 4.74(s, 1H), 5.16(s,



2H), 5.69(s, 1H), 6.81–6.89(m, 3H), 6.96–6.99(m, 2H), 7.10–7.12



(d, J=4.8Hz, 2H), 7.23–7.26(m, 2H), 7.39–7.45(m, 5H)



IR(CHCl3)3597, 3543, 2924, 2871, 1611, 1587, 1522, 1490, 1455,



1382, 1171, 1126, 1012, 836cm−1


I-748
mp 158–161° C.



1H NMR(CDCl3)δ 2.38(s, 3H), 2.74(s, 3H), 3.12(s, 3H), 3.18(s,



3H), 3.57(s, 3H), 3.78(s, 3H), 5.15(s, 2H), 6.86(s, 1H), 7.16(d,



J=8.7Hz, 1H), 7.21–7.24(d, J=7.8Hz, 1H), 7.35–7.40(m, 5H),



7.45–7.49(m, 2H), 7.52–7.62(m, 2H)



IR(CHCl3)2939, 1732, 1614, 1519, 1480, 1331, 1294, 1253, 1176,



1150, 1119, 1082, 1003, 970, 869, 816cm−1

















TABLE 148







I-749
mp 174–176° C.



1H NMR(CDCl3)δ 1.75(s, 3H), 1.79(s, 3H), 2.58(s, 3H), 3.52(s,



3H), 3.53(s, 3H), 3.78(s, 3H), 4.62(d, J=6.9Hz, 2H), 5.48–5.55



(m, 1H), 6.83(s, 1H), 6.99(d, J=8.7Hz, 1H), 7.09(dd, J=1.8, 8.1Hz,



1H), 7.11–7.19(m, 2H), 7.22(d, J=1.8Hz, 1H), 7.57–7.65(m, 2H)



IR(KBr)2932, 1602, 1519, 1485, 1385, 1368, 1174, 1086, 1015,



986, 848, 804, 527cm−1


I-750
mp 129–131° C.



1H NMR(CDCl3)δ 1.75(s, 3H), 1.79(s, 3H), 3.45(s, 3H), 3.53(s,



3H), 3.75(s, 3H), 4.62(d, J=6.6Hz, 2H), 5.24(s, 2H), 5.50–5.58(m,



1H), 5.90(s, 1H), 6.44(s, 1H), 6.99(d, J=8.7Hz, 1H), 7.08–7.18(m,



3H), 7.29(d, J=1.8Hz, 1H), 7.58–7.64(m, 2H)



IR(KBr)3361, 2953, 2934, 1522, 1488, 1460, 1391, 1230, 1154,



1121, 1071, 993, 912, 817, 587cm−1


I-751
mp 148–150° C.



1H NMR(CDCl3)δ 1.68(s, 3H), 1.74(s, 3H), 2.51–2.60(m, 5H),



3.53(s, 6H), 3.77(s, 3H), 4.02(t, J=7.2Hz, 2H), 5.19–5.25(m, 3H),



6.83(s, 1H), 6.98(d, J=8.4Hz, 1H), 7.08(dd, J=2.1, 8.4Hz, 1H),



7.11–7.18(m, 2H), 7.21(d, J=2.1Hz, 1H), 7.57–7.64(m, 2H)



IR(KBr)2931, 1603, 1519, 1484, 1386, 1370, 1231, 1175, 1086,



1015, 983, 961, 847, 728, 526cm−1


I-752
mp 99–101° C.



1H NMR(CDCl3)δ 1.68(s, 3H), 1.73(s, 3H), 2.55(q, J=7.2Hz, 2H),



3.44(s, 3H), 3.54(s, 3H), 3.75(s, 3H), 4.04(t, J=7.2Hz, 2H), 5.20–



5.25(m, 3H), 5.89(s, 1H), 6.44(s, 1H), 6.98(d, J=8.1Hz, 1H), 7.09–



7.18(m, 3H), 7.26–7.27(m, 1H), 7.58–7.63(m, 2H)



IR(KBr)3349, 2930, 1609, 1523, 1489, 1231, 1152, 1121, 1072,



994, 912, 813, 588cm−1

















TABLE 149







I-753
mp 115–117° C.



1H NMR(CDCl3)δ 1.69(s, 3H), 1.75(s, 3H), 2.53(q, J=6.9Hz, 2H),



2.62(s, 3H), 3.53(s, 3H), 3.77(s, 3H), 4.06(t, J=6.9Hz, 2H), 5.18–



5.25(m, 1H), 5.70(s, 1H), 6.83(s, 1H), 6.89–6.95(m, 2H), 7.02(d,



J=1.2Hz, 1H), 7.10–7.18(m, 2H), 7.57–7.65(m, 2H)



IR(KBr)3545, 2931, 1604, 1520, 1485, 1370, 1249, 1232, 1175,



1084, 1012, 813, 526cm−1


I-754
1H NMR(CDCl3)δ 1.14(t, J=6.9Hz, 3H), 1.29(t, J=6.9Hz, 3H),



2.50(s, 3H), 3.19(s, 3H), 3.71(q, J=6.9Hz, 2H), 4.00(q, J=6.9Hz,



2H), 5.18(s, 2H), 5.68(s, 1H), 6.83(s, 1H), 6.91(dd, J=1.8, 8.4Hz,



1H), 7.00(d, J=8.4Hz, 1H), 7.04(d, J=1.8Hz, 1H), 7.32–7.48(m,



7H), 7.66–7.74(m, 2H)



IR(CHCl3)3532, 2976, 1586, 1516, 1468, 1369, 1282, 1174, 1148,



1068, 1016, 967, 907, 871cm−1


I-755
amorphous powder



1H NMR(CDCl3)δ 1.15(t, J=6.9Hz, 3H), 1.28(t, J=6.9Hz, 3H),



3.59(q, J=6.9Hz, 2H), 3.97(q, J=6.9Hz, 2H), 4.89(s, 1H), 5.15(s,



2H), 5.64(s, 1H), 5.98(s, 1H), 6.45(s, 1H), 6.86–6.94(m, 2H),



6.96–7.04(m, 2H), 7.12(d, J=2.4Hz, 1H), 7.35–7.56(m, 7H),



IR(CHCl3)3534, 1610, 1521, 1488, 1383, 1169, 1116, 1064,



1018, 832cm−1


I-756
mp 126–129° C.



1H NMR(CDCl3)δ 1.14(t, J=6.9Hz, 3H), 1.30(t, J=6.9Hz, 3H),



1.76(s, 3H), 1.81(s, 3H), 2.69(s, 3H), 3.20(s, 3H), 3.23(s, 3H),



3.72(q, J=6.9Hz, 2H), 4.00(q, J=6.9Hz, 2H), 4.64(d, J=6.6Hz, 2H),



5.49(m, 1H), 6.84(s, 1H), 7.08(d, J=8.7Hz, 1H), 7.32–7.42(m,



4H), 7.56–7.72(m, 2H)



IR(CHCl3)1609, 1516, 1467, 1369, 1267, 1229, 1175, 1148, 1115,



1069, 968, 907, 871cm−1

















TABLE 150







I-757
mp 123–135° C. (dec.)



1H NMR(CDCl3)δ 1.14(t, J=6.9Hz, 3H), 1.29(t, J=6.9Hz, 3H),



2.37(s, 3H), 2.64(s, 3H), 3.12(s, 3H), 3.20(s, 3H), 3.71(q, J=6.9



Hz, 2H), 4.00(q, J=6.9Hz, 2H), 5.14(s, 2H), 6.83(s, 1H), 7.14(d,



J=8.7Hz, 1H), 7.18–7.24(m, 2H), 7.31–7.40(m, 5H), 7.41(d, J=2.1



Hz, 1H), 7.65–7.72(m, 2H)



IR(CHCl3)1607, 1517, 1467, 1369, 1330, 1268, 1175, 1148, 1116,



1069, 1026, 967, 907, 871cm−1


I-758
amorphous powder



1H NMR(CDCl3)δ 1.15(t, J=6.9Hz, 3H), 1.28(t, J=6.9Hz, 3H),



1.76(s, 3H), 1.82(d, J=0.6Hz, 3H), 3.59(q, J=6.9Hz, 2H), 3.97(q,



J=6.9Hz, 2H), 4.61(d, J=6.9Hz, 2H), 4.87(s, 1H), 5.53(m, 1H),



5.66(s, 1H), 5.97(s, 1H), 6.45(s, 1H), 6.86–7.00(m, 4H), 7.09(d,



J=1.8Hz, 1H), 7.50–7.57(m, 2H)



IR(CHCl3)3528, 2978, 1611, 1521, 1487, 1412, 1383, 1168, 1115,



1064, 905, 831cm−1


I-759
amorphous powder



1H NMR(CDCl3)δ 1.15(t, J=6.9Hz, 3H), 1.27(t, J=6.9Hz, 3H),



2.39(s, 3H), 3.59(q, J=6.9Hz, 2H), 3.97(q, J=6.9Hz, 2H), 4.88(s,



1H), 5.10(s, 2H), 5.64(s, 1H), 5.97(s, 1H), 6.45(s, 1H), 6.97–7.01



(m, 2H), 7.11(d, J=1.5Hz, 1H), 7.20–7.26(m, 2H), 7.32–7.37(m,



2H), 7.50–7.56(m, 2H)



IR(CDCl3)3526, 2974, 1612, 1520, 1488, 1412, 1383, 1285, 1246,



1116, 1065, 1027, 870cm−1


I-760
mp 169–171° C.



1H NMR(CDCl3)δ 2.71(s, 3H), 3.01(s, 3H), 3.10(s, 3H), 3.21(s,



3H), 3.36(s, 3H), 3.56(s, 3H), 3.77(s, 3H), 4.83(s, 2H), 6.84(s,



1H), 7.05(d, J=8.4Hz, 1H), 7.32(dd, J=2.1, 8.4Hz, 1H), 7.36–7.42



(m, 2H), 7.42(d, J=2.1Hz, 1H), 7.65–7.72(m, 2H)



IR(CHCl3)1666, 1517, 1479, 1368, 1175, 1148, 1119, 1083, 1014,



968, 871cm−1

















TABLE 151







I-761
mp 175–177° C.



1H NMR(DMSO-d6)δ 1.70(s, 6H), 3.67–3.73(m, 2H), 3.71(s, 3H),



3.72(s, 3H), 4.59(br, 1H), 5.27–5.31(m, 1H), 6.50(d, J=8.1Hz,



1H), 6.77–6.95(m, 6H), 7.34–7.40(m, 2H), 9.23(br s, 1H), 9.42



(br s, 1H)



IR(KBr)3600–2400(br), 1609, 1522, 1492, 1463, 1384, 1263,



1208, 1174, 1129, 1055, 1033cm−


I-762
mp 151–153° C.



1H NMR(CDCl3)δ 1.78(s, 3H), 1.85(s, 3H), 3.78(s, 3H), 3.80(s,



3H), 4.72(d, J=6.9Hz, 2H), 5.39–5.44(m, 1H), 6.53(d, J=3.0Hz,



1H), 6.95(s, 1H), 7.05(s, 1H), 7.09–7.16(m, 3H), 7.38(d, J=8.7Hz,



1H), 7.45(dd, J=1.8, 8.7Hz, 1H), 7.54–7.60(m, 2H), 7.80(d, J=1.8



Hz, 1H),



IR(KBr)3600–2800(br), 1509, 1496, 1481, 1462, 1447, 1383,



1207, 1158, 1051cm−1


I-763
mp 138–139° C.



1H NMR(CDCl3)δ 3.78(s, 3H), 3.79(s, 3H), 6.64(dd, J=0.9, 2.7Hz,



1H), 6.80(d, J=7.8Hz, 1H), 6.94(s, 1H), 7.04(s, 1H), 7.09–7.21(m,



3H), 7.25–7.27(m, 1H), 7.32(d, J=8.7Hz, 1H), 7.42(dd, J=1.8, 8.4



Hz, 1H), 7.53–7.59(m, 3H), 8.60–8.63(m, 1H)



IR(KBr)3600–2800(br), 1590, 1510, 1497, 1478, 1430, 1384,



1209, 1158, 1053, 1026cm−1


I-764
mp 172–174° C.



1H NMR(CDCl3)δ 2.32(s, 3H), 3.78(s, 3H), 3.79(s, 3H), 5.30(s,



2H), 6.59(d, J=3.3Hz, 1H), 6.94(s, 1H), 7.04(s, 1H), 7.04–7.15(m,



7H), 7.34(d, J=8.4Hz, 1H), 7.41(dd, J=1.8, 8.7Hz, 1H), 7.55–7.59



(m, 2H), 7.82–7.83(m, 1H)



IR(KBr)3600–2800(br), 1516, 1497, 1482, 1466, 1382, 1306,



1219, 1209, 1159, 1051, 1026cm−1


I-765
mp 134–136° C.



1H NMR(DMSO-d6)δ 1.70(s, 3H), 1.71(s, 3H), 3.72–3.74(m, 2H),



3.73(s, 3H), 3.74(s, 3H), 5.25(br s, 1H), 5.50–5.58(m, 1H), 6.66–



6.72(m, 1H), 6.78–6.83(m, 1H), 6.92(s, 3H), 6.95(s, 3H), 7.19–



7.29(m, 2H), 7.30–7.39(m, 2H), 9.45(br s, 3H),



IR(KBr)3600–2800(br), 1624, 1610, 1526, 1494, 1461, 1382,



1255, 1208, 1175, 1120, 1054, 1031cm−1

















TABLE 152







I-766
mp 166–168° C.



1H NMR(CDCl3)δ 2.40(s, 3H), 3.77(s, 6H), 4.82(s, 1H), 6.71(d,



J=2.4Hz, 1H), 6.86–6.93(m, 4H), 7.22–7.32(m, 4H), 7.43–7.48(m,



2H), 7.58–7.64(m, 1H), 7.71–7.75(m, 2H)



IR(KBr)3600–2800(br), 1611, 1524, 1492, 1382, 1336, 1265,



1209, 1162, 1090, 1053, 1030cm−1


I-767
mp 139–140° C.



1H NMR(CDCl3)δ 3.78(s, 3H), 3.80(s, 3H), 6.60–6.62(m, 1H),



6.95(s, 1H), 7.05(s, 1H), m), 7.08–7.16(m, 2H), 7.23–7.26(m,



1H), 7.45(d, J=1.2Hz, 2H), 7.54–7.61(m, 2H), 7.83(d, J=0.6Hz,



1H), 8.18(br s, 1H)



IR(KBr)3600–2800(br), 1520, 1497, 1465, 1448, 1414, 1383,



1313, 1218, 1205, 1159, 1048, 1024cm−1


I-768
1H NMR(CDCl3)δ 2.26(s, 3H), 3.48(s, 3H), 3.75(s, 3H), 5.16(s,



2H), 5.69(s, 1H), 5.89(s, 1H), 6.45(s, 1H), 6.94(d.d, J=8.4&2.1



Hz, 1H), 7.02(d, J=8.4Hz, 1H), 7.08(d, J=2.1Hz, 1H), 7.35–7.50



(m, 8H), 8.36–8.44(m, 1H)



IR(KBr)3384, 1592, 1525, 1487, 1455, 1397, 1312, 1250, 1122,



1102, 1069, 1011cm−1


I-769
1H NMR(CDCl3)δ 2.26(s, 3H), 2.68(s, 3H), 3.13(s, 3H), 3.56(s,



3H), 3.78(s, 3H), 5.19(s, 2H), 6.84(s, 1H), 7.15(d, J=8.4Hz, 1H),



7.30–7.51(m, 10H), 8.37–8.47(m, 1H)



IR(KBr)3384, 1704, 1590, 1524, 1481, 1389, 1357, 1272, 1240,



1174, 1114, 1082, 1017cm−1


I-770
1H NMR(CDCl3)δ 2.67(s, 3H), 2.84(s, 3H), 3.28(s, 3H), 3.56(s,



3H), 3.78(s, 3H), 6.26(s, 1H), 6.85(s, 1H), 7.17(d, J=9.0Hz, 1H),



7.24–7.33(m, 2H), 7.35–7.50(m, 3H), 8.37–8.50(m, 1H)



IR(KBr)3383, 1674, 1595, 1526, 1482, 1363, 1177, 1078, 1012



cm−1


I-771
1H NMR(CDCl3)δ 1.76(s, 3H), 1.81(s, 3H), 2.26(s, 3H), 2.72(s,



3H), 3.23(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 4.64(d, J=7.2Hz, 2H),



5.44–5.53(m, 1H), 6.84(s, 1H), 7.09(.d, J=8.4Hz, 1H), 7.30–7.53



(m, 5H), 8.38–8.47(m, 1H)



IR(KBr)3376, 1697, 1594, 1524, 1481, 1365, 1270, 1239, 1177,



1112, 1079, 1013cm−1

















TABLE 153







I-772
1H NMR(CDCl3)δ 2.26(s, 3H), 2.38(s, 3H), 2.68(s, 3H),



3.12(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 5.14(s, 2H), 6.84(s, 1H),



7.12–7.50(m, 9H), 8.35–8.44(m, 1H)



IR(KBr)3365, 1693, 1622, 1591, 1526, 1477, 1374, 1314, 1291,



1180, 1165, 1111, 1078cm−1


I-773
1H NMR(CDCl3)δ 1.76(s, 3H), 1.82(s, 3H), 2.26(s, 3H),



3.48(s, 3H), 3.75(s, 3H), 4.62(d, J=6.9Hz, 2H),



5.46–5.58(m, 1H), 5.71(s, 1H), 5.86(s, 1H), 6.44(s, 1H),



6.87–7.00(m, 2H), 7.05(.d, J=1.8Hz, 1H), 7.33–7.52(m, 3H),



8.36–8.47(m, 1H)



IR(KBr)1737, 1604, 1519, 1482, 1392, 1366, 1267, 1173, 1131,



1084, 1062, 1009cm−1


I-774
1H NMR(CDCl3)δ: 2.25(s, 3H), 2.38(s, 3H), 3.48(s, 3H),



3.75(s, 3H), 5.10(s, 2H), 5.12(brs, 1H), 5.90(s, 1H), 6.44(s, 1H),



6.94(.d.d, J=8.4&1.8 Hz, 1H), 7.02(.d, J=8.4 Hz, 1H),



7.06(.d, J=1.8Hz, 1H), 7.18–7.52(m, 6H), 8.35–8.44(m, 1H)



IR(KBr)1686, 1590, 1524, 1488, 1398, 1314, 1257, 1102, 1068,



1008cm−1


I-775
1H NMR(CDCl3)δ 3.47(s, 3H), 3.76(s, 3H), 5.16(s, 2H),



5.71(s, 1H), 5.82(s, 1H), 6.45(s, 1H),



6.97(d.d, J=8.4&2.1Hz, 1H), 7.04(d, J=8.4Hz, 1H),



7.07(d, J=2.1Hz, 1H), 7.22–7.30(m, 1H), 7.33–7.49(m, 5H),



7.92–7.98(m, 1H), 8.09–8.14(m, 1H), 10.44(s, 1H)



IR(KBr)3492, 3459, 1692, 1605, 1518, 1486, 1388, 1294, 1238,



1200, 1115, 1100, 1070, 1008cm−1


I-776
1H NMR(CDCl3)δ 2.35(d, J=1.8Hz, 3H), 2.68(s, 3H),



3.13(s, 3H), 3.23(s, 3H), 3.78(s, 3H), 5.19(s, 2H), 6.82(s, 1H),



7.04–7.17(m, 2H), 7.30–7.49(m, 9H)



IR(KBr)1606, 1518, 1478, 1364, 1295, 1271, 1240, 1182, 1118,



1087, 1077, 1017cm−1


I-777
1H NMR(CDCl3)δ 1.76(s, 3H), 1.81(s, 3H), 2.35(s, 3H),



2.72(s, 3H), 3.23(s, 3H), 3.53(s, 3H), 3.78(s, 3H),



4.64(d, J=6.6Hz, 2H), 5.45–5.53(m, 1H), 6.82(s, 1H),



7.03–7.14(m, 2H), 7.32–7.47(m, 4H)



IR(KBr)1607, 1520, 1482, 1374, 1363, 1240, 1179, 1115,



1079cm−1

















TABLE 154







I-778
1H NMR(CDCl3)δ 2.35(d, J=1.2Hz, 3H), 3.45(s, 3H),



3.75(s, 3H), 5.15(s, 2H), 5.68(s, 1H), 5.90(s, 1H), 6.43(s, 1H),



6.92–7.12(m, 4H), 7.31–7.50(m, 7H)



IR(KBr)3536, 3398, 1609, 1587, 1518, 1487, 1244, 1192, 1110,



1071, 1010cm−1


I-779
1H NMR(CDCl3)δ 1.76(s, 3H), 1.82(s, 3H), 2.35(s, 3H),



3.45(s, 3H), 3.74(s, 3H), 4.61(d, J=6.9Hz, 2H),



5.43–5.60(m, 1H), 6.43(s, 1H), 6.87–7.15(m, 4H),



7.36–7.51(m, 2H)



IR(KBr)3512, 3444, 1611, 1585, 1518, 1488, 1462, 1447, 1416,



1305, 1288, 1243, 1207, 1112, 1103, 1070, 1012cm−1


I-780
1H NMR(CDCl3)δ 3.45(s, 3H), 3.75(s, 3H), 4.84(s, 2H),



5.15(s, 2H), 5.70(s, 1H), 5.88(s, 1H), 6.44(s, 1H),



6.91–7.20(m, 4H), 7.32–7.48(m, 5H), 7.52–7.61(m, 1H),



7.64–7.74(m, 1H)



IR(KBr)3523, 3428, 1610, 1587, 1516, 1482, 1463, 1400, 1321,



1285, 1238, 1187, 1106cm−1


I-781
1H NMR(CDCl3)δ 2.68(s, 3H), 3.13(s, 3H), 3.54(s, 3H),



3.78(s, 3H), 5.19(s, 2H), 5.44(d.d, J=18&0.6Hz, 1H),



5.90(d.d, J=18&0.9Hz, 1H), 6.84(s, 1H), 6.86–6.98(m, 1H),



7.09–7.18(m, 2H), 7.31–7.52(m, 8H),



7.71(d.d, J=7.2&2.4Hz, 1H)



IR(KBr)1608, 1518, 1479, 1365, 1235, 1177, 1118, 1079,



1013cm−1


I-782
1H NMR(CDCl3)δ 1.59(d, J=6.3Hz, 3H), 2.68(s, 3H),



3.13(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 5.19(s, 2H),



5.21–5.30(m, 1H), 6.84(s, 1H), 7.08–7.17(m, 3H),



7.32–7.56(m, 7H), 7.69–7.75(m, 1H)



IR(KBr)3543, 3433, 1609, 1518, 1480, 1364, 1235, 1178, 1117,



1078, 1014cm−1


I-783
1H NMR(CDCl3)δ 1.59(d, J=6.0Hz, 3H), 2.01(brs, 1H),



3.47(s, 3H), 3.76(s, 3H), 5.16(s, 2H), 5.15–5.30(m, 1H),



5.72(s, 1H), 5.91(s, 1H), 6.46(s, 1H), 6.89–7.16(m, 4H),



7.30–7.60(m, 6H), 7.68–7.85(m, 1H)



IR(KBr)3467, 1613, 1586, 1517, 1484, 1455, 1421, 1395, 1287,



1238, 1111, 1070, 1010cm−1

















TABLE 155







I-784
1H NMR(CDCl3)δ 1.77(s, 3H), 1.81(s, 3H), 3.23(s, 3H),



3.81(s, 6H), 4.64(d, J=6.6Hz, 2H), 5.47–5.54(m, 1H),



6.91(s, 1H), 6.96(s, 1H), 7.06(.d, J=8.4Hz, 1H),



7.49(d.d, J=8.4&2.1Hz, 1H), 7.58(d, J=2.1Hz, 1H),



7.60–7.74(m, 4H)



IR(KBr)2228, 1610, 1490, 1348, 1295, 1266, 1209, 1174, 1112,



1056, 1038, 1000cm−1


I-785
mp 169–170° C.



1H NMR(CDCl3)δ 2.07(s, 6H), 3.20(s, 3H), 5.16(s, 2H),



5.71(brs, 1H), 6.97–7.45(m, 14H)



IR(KBr)3357, 3023, 2933, 1698, 1516, 1478, 1362, 1260, 1227,



1152, 1132, 962, 869cm−1


I-786
mp 169–170° C.



1H NMR(CDCl3)δ 2.13(s, 6H), 3.11(s, 3H), 3.18(s, 3H),



5.18(s, 2H), 7.09–7.47(m, 12H), 7.64(d, J=9.0Hz, 2H)



IR(KBr)3434, 3035, 2938, 1516, 1474, 1362, 1290, 1197, 1182,



1174, 1149, 1114, 973, 857, 842cm−1


I-787
mp 156–157° C.



1H NMR(CDCl3)δ 2.08(s, 6H), 3.12(s, 3H), 3.21(s, 3H),



5.18(s, 2H), 7.12–7.58(m, 14H)



IR(KBr)3494, 3292, 3033, 2934, 1753, 1712, 1517, 1478, 1358,



1294, 1261, 1173, 1151, 967, 870cm−1


I-788
mp 105–106° C.



1H NMR(CDCl3)δ 1.75(s, 3H), 1.85(s, 3H), 2.12(s, 6H),



3.18(s, 3H), 3.22(s, 3H), 4.64(d, J=7.0Hz, 2H),



5.52(t, J=6.8Hz, 1H), 7.08(s, 1H), 7.16–7.38(m, 6H),



7.64(d, J=8.8 Hz, 2H)



IR(KBr)3434, 2934, 1514, 1474 1362, 1285, 1152, 1113, 971,



916, 861, 845cm−1


I-789
mp 148–149° C.



1H NMR(CDCl3)δ 2.12(s, 6H), 2.39(s, 3H), 3.10(s, 3H),



3.18(s, 3H), 5.13(s, 2H), 7.10–7.38(m, 11H),



7.64(d, J=8.6Hz, 2H)



IR(KBr)3435, 3027, 2931, 1678, 1516, 1475, 1362, 1288, 1182,



1151, 1113, 969, 916, 861cm−1

















TABLE 156







I-790
mp 139–140° C.



1H NMR(CDCl3)δ 1.76(s, 3H), 1.82(s, 3H), 2.14(s, 6H),



2.46–2.58(m, 2H), 3.14(s, 3H), 3.19(s, 3H),



4.07(d, J=7.0Hz, 2H), 5.16–5.23(m, 1H), 7.05(s, 1H),



7.14–7.41(m, 6H), 7.66(d, J=8.4 Hz, 2H)



IR(KBr)3433, 2946, 1514, 1467, 1360, 1282, 1180, 1152, 1115,



868cm−1


I-791
mp 123–124° C.



1H NMR(DMSO-d6)δ 1.72(s, 3H), 1.77(s, 3H), 2.03(s, 6H),



4.56(d, J=6.6Hz, 2H), 5.50(t, J=6.0Hz, 1H),



6.49(d, J=9.6Hz, 1H), 6.55(s, 1H), 6.83(d, J=8.4Hz, 2H),



6.98(d, J=8.1Hz, 1H), 7.27(s, 2H), 7.48(d, J=5.6Hz, 2H),



8.92(brs, 1H), 9.48(brs, 1H)



IR(KBr)3337, 2930, 1612, 1518, 1471, 1285, 1258, 1207, 1123,



999, 834cm−1


I-792
mp 230–231° C.



1H NMR(DMSO-d6)δ 2.04(s, 6H), 2.33(s, 3H), 5.09(s, 2H),



6.50(d, J=8.4Hz, 1H), 6.59(s, 1H), 6.85(d, J=8.1Hz, 2H),



7.04(d, J=5.4Hz, 1H), 7.23(d, J=7.5Hz, 2H), 7.29(s, 1H),



7.41(d, J=7.8Hz, 2H), 7.49(d, J=8.7Hz, 2H), 9.05(brs, 1H),



9.50(brs, 1H)



IR(KBr)3287, 1609, 1519, 1475, 1298, 1245, 1126, 1006,



841cm−1


I-793
mp 118–119° C.



1H NMR(DMSO-d6)δ 1.64(s, 3H), 1.70(s, 3H), 2.03(s, 6H),



2.42–2.50(m, 2H), 3.96(t, J=6.9Hz, 2H), 5.27(t, J=7.2Hz, 2H),



6.49(d, J=8.1Hz, 1H), 655(s, 1H), 6.84(d, J=8.4Hz, 2H),



6.96(d, J=8.1Hz, 1H), 7.27(s, 2H), 7.48(d, J=8.7Hz, 2H),



8.89(brs, 1H), 9.48(brs, 1H)



IR(KBr)3392, 2928, 1610, 1519, 1466, 1250, 1230, 1205, 1178,



1128, 1031, 834, 808cm−1


I-794
mp 139–140° C.



1H NMR(DMSO-d6)δ 1.75(s, 3H), 1.77(s, 3H), 2.50(s, 6H),



3.39(s, 3H), 3.44(s, 3H), 4.69(d, J=6.2Hz, 2H),



5.50(t, J=6.6Hz, 1H), 7.29–7.33(m, 3H), 7.41–7.47(m, 4H),



7.59–7.68(m, 2H)



IR(KBr)3433, 2933, 1675, 1516, 1473, 1366, 1358, 1292, 1259,



1182, 1172, 1151, 969, 873cm−1

















TABLE 157







I-795
mp 151–152° C.



1H NMR(DMSO-d6)δ 2.05(s, 6H), 2.18(s, 3H), 3.36(s, 3h),



3.44(s, 3H), 5.22(s, 2H), 7.08–7.63(m, 13H)



IR(KBr)3434, 3023, 2928, 1517, 1477, 1368, 1293, 1261, 1183,



1152, 966, 870cm−1


I-796
mp 159–160° C.



1H NMR(DMSO-d6)δ 1.65(s, 3H), 1.70(s, 3H), 2.05(s, 6H),



2.48–2.53(m, 2H), 3.38(s, 3H), 3.44(s, 3H), 4.10(t, J=7.4Hz, 2H),



5.21–5.27(m, 1H), 7.28–7.34(m, 3H), 7.41–7.47(m, 4H),



7.59–7.64(m, 2H)



IR(KBr)3434, 2938, 1519, 1478, 1439, 1362, 1295, 1269, 1173,



1152, 1125, 960, 870, 839cm−1


I-797
mp 130–131° C.



1H NMR(DMSO-d6)δ 1.72(s, 3H), 1.75(s, 3H), 2.02(s, 6H),



4.59(d, J=6.4Hz, 2H), 5.48(t, J=7.2Hz, 1H), 6.81–7.07(m, 7H),



7.25(s, 2H), 8.96(brs, 1H), 9.41(brs, 1H)



IR(KBr)3392, 1608, 1589, 1518, 1475, 1322, 1258, 1170, 1127,



974, 836, 808cm−1


I-798
mp 143–144° C.



1H NMR(DMSO-d6)δ 2.03(s, 6H), 2.32(s, 3H), 5.12(s, 2H),



6.82–7.41(m, 13H), 9.10(brs, 1H), 9.41(brs, 1H)



IR(KBr)3344, 1609, 1521, 1427, 1255, 1236, 1205, 1129, 998,



832, 806, 792cm−1


I-799
mp 163–164° C.



1H NMR(DMSO-d6)δ 1.87(s, 3H), 1.90(s, 3H), 3.42(s, 3H),



5.15(s, 2H), 6.88–7.03(m, 4H), 7.24–7.58(m, 9H), 7.97(brs, 1H),



9.02(brs, 1H)



IR(KBr)3563, 3476, 3001, 2922, 1698, 1527, 1512, 1476, 1359,



1303, 1261, 1237, 1210, 1195, 1167, 1146, 871cm−1


I-800
1H NMR(CDCl3)δ 1.30(d, J=6.6Hz, 6H), 2.58(s, 3H),



2.97(quintet, J=6.6Hz, 1H), 3.54(s, 3H), 3.77(s, 3H), 5.17(s, 2H),



6.87(s, 1H), 7.11(d, J=9.0Hz, 1H), 7.22–7.35(m, 8H),



7.47–7.68(m, 6H), 8.19–8.25(m, 2H)



IR(KBr)1737, 1604, 1519, 1482, 1392, 1366, 1267, 1173, 1131,



1084, 1062, 1009cm−1

















TABLE 158







I-801
1H NMR(CDCl3)δ 2.56(s, 3H), 3.55(s, 3H), 3.78(s, 3H),



5.17(s, 2H), 5.69(s, 1H), 6.84(s, 1H),



6.91(d.d, J=8.4&1.8Hz, 1H), 7.02(d, J=8.4Hz, 1H),



7.04(d, J=1.8Hz, 1H), 7.04–7.14(m, 1H), 7.33–7.47(m, 8H)



IR(KBr)3446, 1613, 1585, 1522, 1477, 1396, 1357, 1291, 1243,



1204, 1174, 1076, 1017, 1006cm−1


I-802
foam



1H NMR(CDCl3)δ 2.82(s, 3H), 3.22(s, 3H), 3.25(s, 3H),



3.26(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 5.48(s, 2H), 6.85(s, 1H),



7.27(d, J=8.4Hz, 1H), 7.39(d, J=8.7Hz, 2H),



7.40(dd, J=8.4, 2.1Hz, 1H), 7.43(d, J=2.1Hz, 1H),



7.67(d, J=8.7Hz, 2H)



IR(Nujol)1608, 1519, 1480, 1462, 1365, 1176, 1151, 1079, 970,



876, 798cm−1


I-803
foam



1H NMR(CD3OD)δ 3.28(s, 3H), 3.68(s, 3H), 5.17(s, 2H),



6.43(s, 1H), 6.81(dd, J=8.4, 2.1Hz, 1H), 6.85(d, J=8.7Hz, 2H),



6.89(d, J=2.1Hz, 1H), 7.03(d, J=8.4Hz, 1H),



7.46(d, J=8.7Hz, 2H)



IR(Nujol)3342, 1611, 1592, 1523, 1488, 1460, 1251, 1225, 1114,



1072, 1012, 941, 826, 756cm−1


I-804
mp 150–152° C.



1H NMR(DMSO-d6)δ 3.31(s, 3H), 3.64(s, 3H), 5.00(s, 2H),



6.39(s, 1H), 6.66(dd, J=8.4, 2.1Hz, 1H), 6.79(d, J=2.1Hz, 1H),



6.84(d, J=8.7Hz, 2H), 6.98(d, J=8.4Hz, 1H),



7.44(d, J=8.7Hz, 2H)



IR(Nujol)3459, 3291, 1612, 1594, 1522, 1489, 1458, 1257, 1226,



1101, 1073, 1011, 960, 823cm−1


I-805
mp 190–192° C.



1H NMR(DMSO-d6)δ 2.88(s, 3H), 3.41(s, 3H), 3.45(s, 3H),



3.52(s, 3H), 3.79(s, 3H), 5.43(s, 2H), 7.08(s, 1H), 7.16(s, 1H),



7.32~7.36(m, 2H), 7.46(d, J=8.4Hz, 1H), 7.49(d, J=8.7Hz, 2H),



7.53~7.64(m, 3H), 7.74(d, J=8.7Hz, 2H), 7.88~7.91(m, 2H)



IR(Nujol)1604, 1519, 1481, 1462, 1367, 1175, 1081, 1009, 878,



841, 816, 801cm−1

















TABLE 159







I-806
foam



1H NMR(CDCl3)δ 3.45(s, 3H), 3.74(s, 3H), 5.31(s, 2H),



6.94(s, 1H), 6.45(s, 1H), 6.64(s, 1H), 6.93(d, J=8.7Hz, 2H),



6.98(dd, J=8.4, 2.1Hz, 1H), 7.09(d, J=8.4Hz, 1H),



7.11(d, J=2.1Hz, 1H), 7.46~7.50(m, 3H), 7.53(d, J=8.7Hz, 2H),



7.78~7.82(m, 2H)



IR(Nujol)3367, 1612, 1592, 1523, 1489, 1455, 1253, 1226, 1115,



1073, 1013, 942, 816, 767cm−1


I-807
foam



1H NMR(CDCl3)δ 2.76(s, 3H), 3.21(s, 3H), 3.30(s, 3H),



3.56(s, 3H), 3.78(s, 3H), 5.38(s, 2H), 6.84(s, 1H),



7.21(d, J=8.4Hz, 1H), 7.38(d, J=8.7Hz, 2H),



7.38(dd, J=8.4, 2.1Hz, 1H), 7.45(d, J=2.1Hz, 1H),



7.67(d, J=8.7Hz, 2H), 8.80(s, 1H)



IR(Nujol)1608, 1519, 1480, 1463, 1365, 1177, 1151, 1079, 971,



876, 798cm−1


I-808
mp 193–195° C.



1H NMR(CDCl3)δ 2.64(s, 3H), 2.74(s, 3H), 3.21(s, 3H),



3.30(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 5.28(s, 2H), 6.84(s, 1H),



7.21(d, J=8.4Hz, 1H), 7.38(d, J=8.7Hz, 2H),



7.38(dd, J=8.4, 2.1Hz), 7.44(d, J=2.1Hz, 1H),



7.68(d, J=8.7Hz, 2H)



IR(Nujol)1606, 1591, 1522, 1480, 1463, 1359, 1174, 1152, 1079,



1012, 946, 877, 834, 796cm−1


I-809
foam



1H NMR(CDCl3)δ 1.42(t, J=7.5Hz, 3H), 2.73(s, 3H),



2.96(q, J=7.5Hz, 2H), 3.21(s, 3H), 3.31(s, 3H), 3.56(s, 3H),



3.78(s, 3H), 5.28(s, 2H), 6.84(s, 1H), 7.21(d, J=8.4Hz, 1H),



7.38(d, J=8.7Hz, 2H), 7.38(dd, J=8.4, 2.1Hz, 1H),



7.44(d, J=2.1Hz, 1H), 7.68(d, J=8.7Hz, 2H)



IR(KBr)3434, 1609, 1579, 1519, 1481, 1365, 1177, 1151, 1080,



970, 876, 797cm−1

















TABLE 160







I-810
foam



1H NMR(CDCl3)δ 2.71(s, 3H), 3.21(s, 3H), 3.35(s, 3H),



3.56(s, 3H), 3.78(s, 3H), 5.38(s, 2H), 6.84(s, 1H),



7.25(d, J=8.4Hz, 1H), 7.38(d, J=8.7Hz, 2H),



7.40(dd, J=8.4, 2.1Hz, 1H), 7.46(d, J=2.1Hz, 1H),



7.54~7.64(m, 3H), 7.68(d, J=8.7Hz, 2H), 8.12~8.16(m, 2H)



IR(KBr)3433, 1609, 1561, 1519, 1480, 1365, 1177, 1151, 1081,



971, 876, 798cm−1


I-811
foam



1H NMR(CDCl3)δ 2.51(s, 3H), 2.54(s, 3H), 2.63(s, 3H),



2.72(s, 3H), 3.16(s, 3H), 3.21(s, 3H), 3.56(s, 3H), 3.78(s, 3H),



5.27(s, 2H), 6.84(s, 1H), 7.27(d, J=8.4Hz, 1H),



7.36(dd, J=8.4, 2.1Hz, 1H), 7.38(d, J=8.7Hz, 2H),



7.41(d, J=2.1Hz, 1H), 7.68(d, J=8.7Hz, 2H)



IR(KBr)3435, 1614, 1519, 1480, 1364, 1177, 1151, 1080, 972,



876, 798cm−1


I-812
foam



1H NMR(CDCl3)δ 2.74(s, 6H), 3.17(s, 3H), 3.21(s, 3H),



3.55(s, 3H), 3.78(s, 3H), 5.35(s, 2H), 6.84(s, 1H),



7.28(d, J=8.4Hz, 1H), 7.36(dd, J=8.4, 2.1Hz, 1H),



7.38(d, J=8.7Hz, 2H), 7.41(d, J=2.1Hz, 1H),



7.68(d, J=8.7Hz, 2H), 8.41(d, J=2.4Hz, 1H),



8.50(d, J=2.4Hz, 1H)



IR(KBr)3433, 1609, 1519, 1481, 1364, 1177, 1151, 1080, 971,



876, 798cm−1


I-813
foam



1H NMR(DMSO-d6)δ 2.47(s, 6H), 2.55(s, 3H), 3.30(s, 3H),



3.64(s, 3H), 5.16(s, 2H), 6.39(s, 1H), 6.66(dd, J=8.4, 2.1Hz, 1H),



6.76(d, J=2.1Hz, 1H), 6.84(d, J=8.7Hz, 2H),



7.03(d, J=8.4Hz, 1H), 7.44(d, J=8.7Hz, 2H),



IR(KBr)3399, 3165, 1611, 1521, 1488, 1406, 1362, 1213, 1114,



1069, 1014, 818, 759cm−1

















TABLE 161







I-814
mp 240–241° C.



1H NMR(DMSO-d6)δ 2.66(s, 3H), 3.30(s, 3H), 3.64(s, 3H),



5.26(s, 2H), 6.39(s, 1H), 6.66(dd, J=8.4, 2.1Hz, 1H),



6.77(d, J=2.1Hz, 1H), 6.84(d, J=8.7Hz, 2H),



7.02(d, J=8.4Hz, 1H), 7.44(d, J=8.7Hz, 2H),



8.48(d, J=2.7Hz, 1H), 8.53(d, J=2.7Hz, 1H)



IR(Nujol)3513, 3491, 3070, 1610, 1581, 1523, 1488, 1459, 1408,



1275, 1236, 1216, 1111, 1065, 1040, 821, 785cm−1


I-815
mp 288–290° C. (decomp.)



1H NMR(DMSO-d6)δ 2.89(s, 3H), 3.41(s, 3H), 3.45(s, 3H),



3.52(s, 3H), 3.79(s, 3H), 4.95(s, 2H), 5.65(s, 1H), 7.08(s, 1H),



7.26(d, J=8.4Hz, 1H), 7.33(dd, J=8.4, 2.1Hz, 1H),



7.38(d, J=2.1Hz, 1H), 7.49(d, J=8.7Hz, 2H),



7.74(d, J=8.7Hz, 2H),



IR(Nujol)3120, 1712, 1671, 1604, 1516, 1480, 1462, 1364, 1172,



1078, 1015, 970, 874, 841, 796cm−1


I-816
mp 204–206° C.



1H NMR(DMSO-d6)δ 2.87(s, 3H), 3.45(s, 3H), 3.46(s, 3H),



3.52(s, 3H), 3.78(s, 3H), 5.40(s, 2H), 7.08(s, 1H),



7.32(dd, J=8.4, 2.1Hz, 1H), 7.33(d, J=8.4Hz, 1H),



7.39(d, J=2.1Hz, 1H), 7.48(d, J=8.7Hz, 2H),



7.71(dd, J=5.1, 1.2Hz, 1H), 7.74(d, J=8.7Hz, 2H),



8.88(d, J=5.1Hz, 1H), 9.21(d, J=1.2Hz, 1H)



IR(Nujol)1608, 1586, 1557, 1521, 1480, 1464, 1360, 1352, 1176,



1156, 1078, 884, 835, 818, 799cm−1


I-817
foam



1H NMR(CDCl3)δ 2.20(s, 3H), 3.45(s, 3H), 3.75(s, 3H),



5.15(s, 2H), 6.45(s, 1H), 6.92(d, J=8.7Hz, 2H),



6.94(dd, J=1.8, 8.4Hz, 1H), 6.98(d, J=8.4Hz, 1H),



7.09(d, J=1.8Hz, 1H), 7.18(m, 1H), 7.37(t, J=7.2Hz, 1H),



7.53(d, J=8.7Hz, 2H), 7.55(m, 2H)

















TABLE 162







I-818
m.p 163–166° C.



1H NMR(CDCl3)δ 1.53(s, 9H), 2.67(s, 3H), 3.11(s, 3H),



3.21(s, 3H), 3.56(s, 3H), 3.77(s, 3H), 5.12(s, 2H), 6.52(s, 1H),



6.84(s, 1H), 7.13(d, J=8.4Hz, 1H), 7.33(dd, J=2.1, 8.4Hz, 1H),



7.38(d, J=8.7Hz, 2H), 7.39(m, 5H), 7.74(d, J=8.7Hz, 2H)



IR(KBr)1692, 1614, 1520, 1480, 1390, 1367, 1231, 1175, 1152,



1078, 876, 799cm−1


I-819
m.p 172° C.



1H NMR(CDCl3)δ 2.77(s, 3H), 3.05(s, 3H), 3.16(s, 3H),



3.22(s, 3H), 3.36(s, 3H), 3.78(s, 3H), 5.16(s, 2H), 6.46(s, 1H),



6.85(s, 1H), 7.14(d, J=8.4Hz, 1H), 7.25(d, J=8.7Hz, 2H),



7.35(dd, J=2.1, 8.4Hz, 1H), 7.39(d, J=8.7Hz, 2H),



7.40(d, J=2.1, 1H), 7.47(d, J=8.4Hz, 2H),



7.67(d, J=8.7Hz, 2H)



IR(KBr)1608, 1519, 1480, 1361, 1175, 1154, 1079, 972, 876,



801cm−1


I-820
mp 180–182° C.



1H NMR(CDCl3)δ 2.69(s, 3H), 3.14(s, 3H), 3.21(s, 3H),



3.53(s, 3H), 3.71(d, J=0.9Hz, 3H), 5.20(s, 2H),



6.93(d, J=8.4Hz, 1H), 7.34–7.49(m, 9H),



7.59(dd, J=9.0, 1.2Hz, 2H)



IR(KBr)1518, 1469, 1357, 1179, 1151, 1038, 871, 821cm−1


I-821
mp 183–185° C.



1H NMR(CDCl3)δ 3.41(s, 3H), 3.66(d, J=0.9Hz, 3H),



4.91(s, 1H), 5.17(s, 2H), 5.62(s, 1H), 5.70(s, 1H),



6.92–6.96(m, 2H), 6.97(dd, J=8.4, 2.0Hz, 1H),



7.04(d, J=8.4Hz, 1H), 7.10(d, J=2.0Hz, 1H), 7.36–7.48(m, 7H)



IR(KBr)3541, 3398, 1588, 1523, 1461, 1410, 1320, 1261, 1217,



1037, 836, 747cm−1


I-822
mp 108–110° C.



1H NMR(CDCl3)δ 2.69(s, 3H), 3.13(s, 3H), 3.45(s, 3H),



3.53(s, 3H), 3.77(s, 3H), 4.66(s, 2H), 4.76(s, 2H), 5.19(s, 2H),



6.86(s, 1H), 7.71(d, J=8.4Hz, 1H), 7.33–7.48(m, 9H),



7.62(d, J=8.4Hz, 2H)



IR(KBr)1482, 1390, 1307, 1276, 1177, 1083, 1053, 1013,



807cm−1

















TABLE 163







I-823
mp 192–194° C.



1H NMR(CDCl3)δ 1.70(br s, 1H), 2.69(s, 3H), 3.13(s, 3H),



3.53(s, 3H), 3.77(s, 3H), 4.78(s, 2H), 5.19(s, 2H), 6.87(s, 1H),



7.15(d, J=8.4Hz, 1H), 7.35(dd, J=8.4, 2.3Hz, 1H),



7.37–7.49(m, 8H), 7.63(d, J=7.8Hz, 2H)



IR(KBr)3554, 3434, 1522, 1481, 1389, 1364, 1277, 1234, 1174,



1085, 1012, 807cm−1


I-824
mp 135–137° C.



1H NMR(CDCl3)δ 3.19(s, 3H), 3.60(s, 3H), 3.71(s, 3H),



4.96(s, 1H), 5.18(s, 2H), 5.78(s, 1H), 6.73(s, 1H),



6.88(dd, J=8.3, 2.1Hz, 1H), 7.02(d, J=2.1Hz, 1H),



7.08(d, J=8.3Hz, 1H), 7.34(d, J=8.6Hz, 2H),



7.41–7.47(m, 5H), 7.63(d, J=8.6Hz, 2H)



IR(KBr)3479, 1473, 1347, 1149, 1010, 869, 803, 784, 747cm−1


I-825
mp 149–151° C.



1H NMR(CDCl3)δ 2.68(s, 3H), 3.13(s, 3H), 3.20(s, 3H),



3.69(s, 3H), 3.71(s, 3H), 5.20(s, 2H), 7.18(d, J=8.7Hz, 1H),



7.21(s, 1H), 7.35–7.50(m, 9H), 7.63(d, J=8.1Hz, 2H)



IR(KBr)1519, 1469, 1353, 1173, 1149, 1050, 966, 873, 849,



810cm–1


I-826
mp 82–85° C.



1H NMR(CDCl3)δ 1.78(s, 3H), 1.82(s, 3H), 2.70(s, 3H),



3.20(s, 3H), 3.25(s, 3H), 3.69(s, 3H), 3.70(s, 3H),



4.65(d, J=6.9Hz, 2H), 5.51(t, J=6.9Hz, 1H),



7.11(d, J=8.8Hz, 1H), 7.21(s, 1H), 7.37(d, J=8.9Hz, 2H),



7.38(dd, J=8.8, 2.2Hz, 1H), 7.42(d, J=2.2Hz, 1H),



7.63(d, J=8.9Hz, 2H)



IR(KBr)1516, 1468, 1363, 1180, 1151, 1045, 967, 846, 788cm−1


I-827
amorphous



1H NMR(CDCl3)δ 1.77(s, 3H), 1.83(s, 3H), 3.58(s, 3H),



3.70(s, 3H), 4.64(d, J=6.7(Hz, 2H), 4.97(s, 1H), 5.04(s, 1H),



5.53(t, J=6.7Hz, 1H), 5.81(s, 1H), 6.73(s, 1H),



6.87(dd, J=8.1, 2.0Hz, 1H), 6.88(d, J=8.7Hz, 2H),



6.99(d, J=2.0Hz, 1H), 7.00(d, J=8.1Hz, 1H),



7.47(d, J=8.7Hz, 2H)



IR(CHCl3)3595, 3536, 1613, 1584, 1521, 1474, 1406, 1356,



1266, 1094, 1062, 1014, 973, 835cm−1

















TABLE 164







I-828
mp 161–162° C.



1H NMR(CDCl3)δ 3.58(s, 3H), 3.71(s, 3H), 4.85(s, 1H),



4.93(s, 1H), 5.18(s, 2H), 5.78(s, 1H), 6.73(s, 1H),



6.87–6.92(m, 3H), 7.02(d, J=1.8Hz, 1H), 7.07(d, J=8.1Hz, 1H),



7.37–7.51(m, 7H)



IR(KBr)3510, 3442, 3326, 1523, 1485, 1453, 1395, 1239, 1061,



1003, 972, 836, 753cm−1


I-829
mp 85–87° C.



1H NMR(CDCl3)δ 1.69(s, 3H), 1.75(s, 3H),



2.57(q, J=6.9Hz, 2H), 2.70(s, 3H), 3.20(s, 3H), 3.24(s, 3H),



3.69(s, 3H), 3.69(s, 3H), 4.09(t, J=6.9Hz, 2H),



5.22(t, J=6.9Hz, 1H), 7.10(d, J=8.4Hz, 1H), 7.21(s, 1H),



7.37–7.44(m, 9H), 7.63(d, J=8.4Hz, 2H)



IR(KBr)1519, 1468, 1362, 1179, 1150, 1046, 967, 865, 847cm−1


I-830
mp 160–162° C.



1H NMR(CDCl3)δ 2.38(s, 3H), 2.68(s, 3H), 3.12(s, 3H),



3.20(s, 3H), 3.69(s, 3H), 3.70(s, 3H), 5.15(s, 2H),



7.16–7.25(m, 4H), 7.34–7.44(m, 6H), 7.63(d, J=8.1Hz, 2H)



IR(KBr)1519, 1469, 1365, 1173, 1149, 1049, 965, 873, 849,



808cm−1


I-831
amorphous



1H NMR(CDCl3)δ 1.69(s, 3H), 1.76(s, 3H),



2.55(q, J=6.9Hz, 1H), 3.58(s, 3H), 3.69(s, 3H),



4.08(t, J=6.9Hz, 2H), 4.98(s, 1H), 5.18(s, 1H),



5.23(t, J=6.9Hz, 1H), 5.80(s, 1H), 6.72(s, 1H),



6.86–6.89(m, 3H), 6.97–7.00(m, 3H), 7.47(d, J=8.4Hz, 2H)



IR(KBr)3595, 3538, 1521, 1471, 1265, 1173, 1095, 1063,



1015, 835cm−1


I-832
mp 200–201° C.



1H NMR(CDCl3)δ 2.40(s, 3H), 3.58(s, 3H), 3.70(s, 3H),



4.80(s, 1H), 4.92(s, 1H), 5.13(s, 2H), 5.77(s, 1H),



6.73(s, 1H), 6.88(dd, J=8.1, 2.0Hz, 1H), 6.89(d, J=8.4Hz, 2H),



7.01(d, J=1.8Hz, 1H), 7.07(d, J=8.4Hz, 1H),



7.24(d, J=7.8Hz, 2H), 7.35(d, J=7.8Hz, 2H),



7.48(d, J=8.4Hz, 2H),



IR(KBr)3419, 1610, 1523, 1485, 1393, 1243, 1065, 1004, 972,



833, 795cm−1

















TABLE 165







I-833
mp 141–142° C.



1H NMR(CDCl3)δ 2.03(s, 3H), 2.11(s, 3H), 2.54(s, 3H),



3.15(s, 3H), 3.21(s, 3H), 5.20(s, 2H), 7.12–7.26(m, 5H),



7.38–7.50(m, 8H)



IR(KBr)3435, 3033, 2938, 1518, 1470, 1364, 1178, 1149, 1109,



970, 871, 839cm−1


I-834
mp 188–189° C.



1H NMR(CDCl3)δ 3.49(s, 3H), 3.72(s, 3H), 5.15(s, 2H),



5.68(brs, 1H), 5.84(brs, 1H), 6.42–6.56(m, 3H),



6.98–7.08(m, 3H), 7.23–7.31(m, 3H), 7.23–7.31(m, 2H),



7.38–7.45(m, 4H)



IR(KBr)3420, 3328, 1627, 1584, 1523, 1489, 1460, 1412, 1316,



1288, 11249, 1172, 1128, 1115, 1068, 1000, 849, 812, 746cm−1


I-835
mp 180–181° C.



1H NMR(CDCl3)δ 3.51(s, 3H), 3.75(s, 3H), 5.17(s, 2H),



5.70(brs, 1H), 5.77(brs, 1H), 6.45(s, 1H), 6.95–7.10(m, 4H),



7.27–7.46(m, 8H), 7.96(brs, 1H))



IR(KBr)3422, 3358, 1706, 1602, 1489, 1454, 1410, 1289, 1253,



1203, 1180, 1125, 1101, 1071, 1015cm−1


I-836
mp 148–149° C.



1H NMR(DMSO-d6)δ 1.77(s, 3H), 1.80(s, 3H), 2.54(s, 6H),



3.35(s, 3H), 3.42(s, 3H), 3.48(s, 3H), 4.73(d, J=4.5Hz, 2H),



5.50–5.53(m, 1H), 7.30–7.54(m, 8H)



IR(KBr)3495, 3293, 1754, 1712, 1516, 1359, 1359, 1243, 1175,



1147, 971, 866, 845cm−1


I-837
mp 136–138° C.



1H NMR(DMSO-d6)δ 2.32(s, 3H), 2.50(s, 6H), 3.31(s, 3H),



3.35(s, 3H), 3.44(s, 3H), 5.23(s, 2H), 7.21–7.47(m, 12H)



IR(KBr)3495, 3292, 3028, 2934, 1754, 1710, 1516, 1357, 1176,



1147, 972, 868, 842cm−1

















TABLE 166







I-838
mp 195–196° C.



1H NMR(CDCl3)δ 1.44(t, J=7.2Hz, 3H), 3.46(s, 3H), 3.69(s, 3H),



3.86(s, 6H), 4.44(q, J=7.0Hz, 2H),5.15(s, 2H),



5.66(brs, 1H), 5.72(brs, 1H), 6.27(s, 1H), 7.01(s, 2H),



7.13(s, 1H), 7.38–7.46(m, 7H)



IR(KBr)3485, 2937, 1713, 1580, 1464, 1455, 1407, 1324, 1243,



1123, 1102, 1069, 1014, 763cm−1


I-839
mp 150–151° C.



1H NMR(DMSO-d6)δ 1.72(s, 3H), 1.76(s, 3H), 1.88(s, 3H),



1.90(s, 3H), 4.55(d, J=5.8Hz, 2H), 5.44–5.50(m, 1H),



6.80–6.97(m, 8H), 7.81(brs, 1H), 8.85(brs, 1H), 9.38(brs, 1H)



IR(KBr)3495, 3293, 1753, 1711, 1429, 1390, 1360, 1242, 1217,



1178, 1143, 781cm−1


I-840
mp 149–150° C.



1H NMR(DMSO-d6)δ 1.71(s, 3H), 1.75(s, 3H), 2.00(s, 6H),



2.59(s, 3H), 4.57(d, J=6.4Hz, 2H), 5.42–5.47(m, 1H),



6.84–7.13(m, 8H), 9.13(brs, 1H), 9.50(brs, 1H)



IR(KBr)3451, 2933, 1612, 1587, 1518, 1472, 1348, 1259, 1211,



1171, 1121, 1087, 969, 872, 835, 813cm−1


I-841
mp 203–204° C.



1H NMR(DMSO-d6)δ 1.87(s, 3H), 1.89(s, 3H), 2.31(s, 3H),



5.09(s, 2H), 6.80–7.00(m, 8H), 7.20(d, J=7.8Hz, 2H),



7.39(d, J=7.8Hz, 2H), 7.81(brs, 1H), 8.97(brs, 1H), 9.38(brs, 1H)



IR(KBr)3491, 3398, 2921, 1611, 1516, 1476, 1259, 1183, 1155,



996, 794cm−1


I-842
mp 128–129° C.



1H NMR(DMSO-d6)δ 2.01(s, 6H), 2.34(s, 3H), 2.63(s, 3H),



5.12(s, 2H), 6.85–7.13(m, 8H), 7.18(d, J=7.6Hz, 2H),



7.36(d, J=7.6Hz, 2H), 9.15(brs, 1H), 9.55(brs, 1H)



IR(KBr)3432, 3305, 1735, 1607, 1523, 1482, 1398, 1360, 1294,



1284, 1179, 1080, 816cm−1

















TABLE 167







I-843
mp 203–204° C.



1H NMR(CDCl3)δ 2.66(s, 3H), 3.13(s, 3H), 3.59(s, 3H),



3.76(s, 3H), 5.19(s, 2H), 6.85(s, 1H), 7.13–7.69(m, 11H),



8.07(brs, 1H)



IR(KBr)3432, 3305, 1735, 1607, 1523, 1482, 1398, 1360, 1294,



1284, 1179, 1080, 816cm−1


I-844
mp 109–110° C.



1H NMR(DMSO-d6)δ 1.36(t, J=7.2Hz, 3H), 2.82(s, 3H),



3.24(s, 3H), 3.47(s, 3H), 3.66(s, 3H), 3.79(s, 6H),



4.38(q, J=7.0Hz, 2H), 5.26(s, 2H), 6.78(s, 1H),



7.32–7.52(m, 10H)



IR(KBr)3432, 2940, 1716, 1579, 1465, 1407, 1366, 1322, 1240,



1179, 1123, 1078, 815, 796cm−1


I-845
mp 113–115° C.



1H NMR(CDCl3)δ 2.25(s, 3H), 2.27(s, 3H), 3.20(s, 3H),



5.20(s, 2H), 7.03–7.15(m, 5H), 7.33–7.51(m, 9H))



IR(CHCl3)2925, 1618, 1580, 1521, 1455, 1373, 1314, 1299,



1268, 1174, 1149, 1126, 1018, 970, 874cm−1


I-846
mp 155–157° C.



1H NMR(CDCl3)δ 2.26(s, 6H), 4.69(s, 1H), 5.19(s, 2H),



6.87–6.90(m, 2H), 7.03–7.15(m, 5H), 7.22–7.50(m, 7H)



IR(CHCl3)3596, 2952, 2924, 1612, 1582, 1523, 1490, 1455,



1425, 1383, 1259, 1171, 1125, 1012, 956, 877cm−1


I-847
mp 81–84° C.



1H NMR(CDCl3)δ 1.07–1.14(m, 6H), 2.55–2.66(m, 4H),



4.73(s, 1H), 5.16(s, 2H), 5.70(s, 1H), 6.82–6.91(m, 3H),



6.92–6.99(m, 2H), 7.10–7.12(d, J=4.2Hz, 2H), 7.22–7.25(m, 2H),



7.38–7.49(m, 5H)



IR(CHCl3)3596, 3542, 2968, 2932, 2872, 1731, 1611, 1588,



1520, 1489, 1455, 1380, 1327, 1289, 1256, 1171, 1126, 1011,



903, 878, 836cm−1


I-848
mp 125–127° C.



1H NMR(CDCl3)δ 1.77(s, 3H), 1.82(s, 3H), 2.26(s, 3H),



2.28(s, 3H), 3.20(s, 3H), 4.63–4.65(d, J=6.9Hz, 2H),



5.56(m, 1H), 7.02–7.13(m, 5H), 7.31–7.43(m, 4H)



IR(CHCl3)2924, 1619, 1578, 1488, 1373, 1298, 1266, 1174,



1149, 1125, 970, 874cm−1

















TABLE 168







I-849
mp 141–143° C.



1H NMR (CDCl3)δ 1.07–1.14(m, 6H), 2.53–2.65(m, 4H), 3.12(s,



3H), 3.20(s, 3H), 5.18(s, 2H), 7.10–7.14(m, 3H), 7.24–7.27(m,



2H), 7.33–7.50(m, 9H)



IR(CHCl3)2969, 2934, 1614, 1517, 1487, 1371, 1331, 1289,



1263, 1173, 1149, 1111, 970, 938, 872cm−1


I-850
mp 90–91° C.



1H NMR (CDCl3)δ 2.13(s, 3H), 2.29(s, 3H), 2.35(s, 3H), 3.16(s,



3H), 5.21(s, 2H), 6.87–6.90(m, 2H), 7.09–7.49(m, 11H)



IR(CHCl3)3596, 1731, 1613, 1520, 1478, 1362, 1261, 1173, 1119,



1086, 1025, 972, 953, 874cm−1


I-851
mp 94–96° C.



1H NMR (CDCl3)δ 1.76–1.77(d, J=0.3Hz, 3H), 1.81–1.82(d,



J=0.9Hz, 3H), 2.26(s, 3H), 2.27(s, 3H), 4.62–4.64(d, J=6.9Hz,



2H), 4.71(s, 1H), 5.56(m, 1H), 6.87–6.91(m, 2H), 7.00–7.13(m,



5H), 7.23–7.27(m, 2H)



IR(CHCl3)3596, 2923, 1675, 1613, 1579, 1523, 1490, 1386,



1297, 1171, 1124, 990, 956, 877, 836cm−1


I-852
mp 106–108° C.



1H NMR (CDCl3)δ 2.63(s, 3H), 3.52(s, 3H), 3.77(s, 3H), 5.24(s,



2H), 6.84(s, 1H), 6.84(s, 1H), 7.12–7.20(m, 3H), 7.35–7.50(m,



7H), 7.56–7.64(m, 2H)



IR(KBr)2935, 1604, 1523, 1483, 1373, 1232, 1086, 1011, 945,



847, 728, 605, 523, 506cm−1


I-853
mp 136–138° C.



1H NMR (CDCl3)δ 1.77(s, 3H), 1.81(s, 3H), 2.67(s, 3H), 3.53(s,



3H), 3.78(s, 3H), 4.67(d, J=6.9Hz, 2H), 5.47–5.53(m, 1H),



6.84(s, 1H), 7.10–7.19(m, 3H), 7.31(d, J=2.1Hz, 1H), 7.38(dd,



J=2.1, 8.1Hz, 1H), 7.57–7.64(m, 2H)



IR(KBr)2936, 1604, 1523, 1484, 1435, 1373, 1225, 1086, 1011,



943, 848, 783, 606, 508cm−1

















TABLE 169







I-854
mp 128–130° C.



1H NMR (CDCl3)δ 1.74(s, 3H), 1.81(s, 3H), 2.62(s, 3H), 3.52(s,



3H), 3.79(s, 3H), 4.63–4.67(m, 2H), 5.45–5.53(m, 1H), 6.86(s,



1H), 7.01(dd, J=2.1Hz, 8.4Hz, 1H), 7.10(d, J=1.8Hz, 1H),



7.13–7.20(m, 2H), 7.29(d, J=8.4Hz, 1H), 7.59–7.64(m, 2H)



IR(KBr)2940, 1600, 1518, 1484, 1418, 1366, 1232, 1080, 984,



893, 838, 812, 621, 534cm−1


I-855
mp 141–143° C.



1H NMR (CDCl3)δ 1.76(s, 3H), 1.82(s, 3H), 2.61(s, 3H), 3.53(s,



3H), 3.77(s, 3H), 4.62(d, J=6.9Hz, 2H), 5.47–5.53(m, 1H),



5.70(s, 1H), 6.83(s, 1H), 6.91(dd, J=2.1, 8.1Hz, 1H), 6.96(d,



J=8.1Hz, 1H), 7.02(d, J=2.1Hz, 1H), 7.10–7.19(m, 2H),



7.59–7.64(m, 2H)



IR(KBr)3531, 2931, 1604, 1520, 1484, 1372, 1233, 1175, 1083,



1011, 814, 800, 781, 727, 526cm−1


I-856
mp 217–220° C.



1H NMR (CDCl3)δ 2.75(s, 3H), 3.51(s, 3H), 3.78(s, 3H), 5.78(s,



1H), 6.85(s, 1H), 7.03(dd, J=1.8, 8.4Hz, 1H), 7.11–7.20(m,



3H), 7.32(d, J=8.4Hz, 1H), 7.58–7.63(m, 2H)



IR(KBr)3434, 2941, 1611, 1487, 1423, 1363, 1209, 1076, 891,



818, 621, 573, 513cm−1


I-857
mp 183–185° C.



1H NMR (CDCl3)δ 1.92(s, 3H), 3.20(s, 3H), 3.53(s, 3H), 3.78(s,



3H), 3.93(s, 3H), 4.31(s, 4H), 6.79–6.83(m, 2H), 6.90–6.94(m,



2H), 7.16–7.41(m, 12H), 7.66–7.71(m, 2H),



IR(KBr)3030, 2936, 1604, 1517, 1482, 1362, 1232, 1232, 1180,



1120, 1082, 877, 799, 701, 526cm−1


I-858
mp 192–194° C.



1H NMR (CDCl3)δ 2.57(s, 3H), 3.21(s, 3H), 3.56(s, 3H), 3.77(s,



3H), 3.87(s, 3H), 6.77–6.89(m, 4H), 7.34–7.40(m, 2H),



7.67–7.72(m, 2H)



IR(KBr)3451, 3368, 2937, 1622, 1524, 1481, 1359, 1114, 1149,



1086, 962, 869, 802, 525cm−1

















TABLE 170







I-859
mp 210–212° C.



1H NMR (CDCl3)δ 1.92(s, 3H), 2.23(s, 3H), 3.46(s, 3H), 3.74(s,



3H), 3.89(s, 3H), 5.24(s, 1H), 5.80(s, 1H), 5.94(s, 1H), 6.46(s,



1H), 6.90–6.96(m, 1H), 7.01(d, J=1.8Hz, 1H), 7.08(dd,



J=1.8, 8.1Hz, 1H), 7.50–7.55(m, 2H), 7.76(s, 1H), 8.52(d,



J=8.1Hz, 1H),



IR(KBr)3420, 2938, 1636, 1610, 1526, 1496, 1398, 1225, 1164,



1073, 1026, 831cm−1


I-860
mp 183–185° C.



1H NMR (DMSO-d6)δ 2.43(s, 6H), 2.45(s, 6H), 5.13(s, 2H),



6.76–6.82(m, 4H), 6.91(dd, J=2.1, 8.4Hz, 1H), 7.01(d, J=8.4Hz,



1H), 7.09(d, J=2.1Hz, 1H), 7.31–7.43(m, 5H), 7.48–7.53(m,



2H), 9.02(brs, 1H), 9.32(brs, 1H)



IR(KBr)3600–2800(br), 1609, 1581, 1521, 1493, 1455, 1437,



1384, 1321, 1275, 1215, 1193, 1142, 1007cm−1


I-861
mp 172–174° C.



1H NMR (CDCl3)δ 2.50(s, 6H), 2.53(s, 6H), 3.11(s, 3H), 3.19(s,



3H), 5.18(s, 2H), 6.89(s, 1H), 6.93(s, 1H), 7.12(d, J=8.4Hz,



1H), 7.30–7.54(m, 8H), 7.66–7.71(m, 2H), 7.73(d, J=2.1Hz, 1H)



IR(KBr)3600–2800(br), 1613, 1518, 1491, 1455, 1361, 1348,



1276, 1178, 1159, 1109, 970cm−1


I-862
mp 173–175° C.



1H NMR (CDCl3)δ 1.77(s, 3H), 1.82(s, 3H), 2.51(s, 6H), 2.53(s,



6H), 3.19(s, 3H), 3.22(s, 3H), 4.63(d, J=7.2Hz, 2H), 5.49–5.53(m,



1H), 6.89(s, 1H), 6.93(s, 1H), 7.05(d, J=9.0Hz, 1H), 7.26–7.35(m,



2H), 7.51(dd, J=1.8, 8.1Hz, 1H), 7.67–7.70(m, 3H)



IR(KBr)3600–2800(br), 1519, 1491, 1363, 1331, 1291, 1257,



1175, 1147, 1105, 1013, 980, 966cm−1


I-863
mp 150–152° C.



1H NMR (DMSO-d6)δ 1.72(s, 3H), 1.76(s, 3H), 2.43(s, 6H),



2.45(s, 6H), 4.55(d, J=6.6Hz, 2H), 5.47–5.51(m, 1H),



6.78–6.83(m, 4H), 6.90–7.06(m, 3H), 7.38–7.42(m, 2H), 8.87(brs,



1H), 9.39(brs, 1H)



IR(KBr)3600–2800(br), 1610, 1585, 1522, 1495, 1476, 1448,



1385, 1292, 1275, 1199, 1171, 1136, 985, 948cm−1

















TABLE 171







I-864
mp 175–177° C.



1H NMR (DMSO-d6)δ 2.44(s, 12H), 5.13(s, 4H), 6.77(s, 2H),



6.90–7.09(m, 8H), 7.33–7.52(m, 8H), 9.01(s, 2H)



IR(KBr)3600–2800(br),1582, 1518, 1491, 1454, 1384, 1328,



1270, 1242, 1191, 1141, 1123, 1046, 1006cm−1


I-865
mp 175–177° C.



1H NMR (CDCl6)δ 2.52(s, 12H), 3.11(s, 6H), 5.17(s, 4H), 6.91(s,



2H), 7.11(d, J=8.4Hz, 2H), 7.36–7.52(m, 12H), 7.72(d, J=2.1Hz,



2H)



IR(KBr)3600–2800(br), 1612, 1520, 1496, 1455, 1304, 1348,



1265, 1184, 1164, 1117, 1005, 971cm−1


I-866
mp 180–182° C.



1H NMR (CDCl3)δ 1.77(s, 6H), 1.81(s, 6H), 2.52(s, 12H), 3.22(s,



6H), 4.63(d, J=6.9Hz, 2H), 5.49–5.54(m, 2H), 6.90(s, 2H), 7.04(d,



J=8.4Hz, 2H), 7.50(dd, J=2.1, 8.4Hz, 2H), 7.04(d, J=2.1Hz, 2H)



IR(KBr)3600–2800(br), 1520, 1494, 1365, 1274, 1186, 1161,



1113, 996, 973cm−1


I-867
mp 165–168° C.



1H NMR (DMSO-d6)δ 1.72(s, 6H), 1.76(s, 6H), 2.45(s, 12H),



4.55(d, J=6.0Hz, 4H), 5.45–5.55(m, 2H), 6.77(s, 2H),



6.89–6.98(m, 4H), 7.03–7.07(m, 2H), 8.86(brs, 2H)



IR(KBr) 3600–2800(br), 1579, 1519, 1497, 1476, 1456, 1384,



1277, 1238, 1195, 1142, 1126, 1050, 994cm−1


I-868
mp 76–78° C.



1H NMR (CDCl3)δ 3.47(s, 3H), 3.75(s, 3H), 3.94(s, 3H), 5.15(s,



2H), 5.68(s, 1H), 5.69(s, 1H), 5.92(s, 1H), 6.46(s, 1H),



6.93–7.15(m, 5H), 7.22(d, J=1.5Hz, 1H), 7.34–7.49(m, 5H)



IR(CHCl3)3528, 1586, 1520, 1489, 1461, 1399, 1287, 1260,



1110, 1070, 1010, 907, 819cm−1


I-869
mp 140–142° C.



1H NMR (CDCl3)δ 2.65(s, 3H), 3.13(s, 3H), 3.25(s, 3H), 3.57(s,



3H), 3.78(s, 3H), 3.94(s, 3H), 5.19(s, 2H), 6.85(s, 1H),



7.13–7.19(m, 2H), 7.30–7.50(m, 9H)



IR(CHCl3)1598, 1516, 1480, 1367, 1266, 1176, 1115, 1081,



1012, 969, 918, 867, 808cm−1

















TABLE 172







I-870
mp 189–190° C.



1H NMR (CDCl3)δ 1.76(d, J=0.9Hz, 3H), 1.81(s, 3H), 2.69(s,



3H), 3.24(s, 3H), 3.25(s, 3H), 3.58(s, 3H), 3.78(s, 3H), 3.94(s,



3H), 4.64(d, J=6.6Hz, 2H), 5.49(m, 1H), 6.85(s, 1H), 7.10(d,



J=8.4Hz, 1H), 7.17(d.d, J=2.1, 8.4Hz, 1H), 7.30–7.42(m, 4H)



IR(CHVl3)2932, 1599, 1516, 1480, 1367, 1329, 1266, 1177, 1115,



1082, 1032, 1013, 970, 907, 868, 807cm−1


I-871
mp 187–190° C.



1H NMR (CDCl3)δ 2.38(s, 3H), 2.64(s, 3H), 3.13(s, 3H), 3.25(s,



3H), 3.58(s, 3H), 3.78(s, 3H), 3.94(s, 3H), 5.14(s, 2H), 6.84(s,



1H), 7.13–7.24(m, 4H), 7.30–7.42(m, 6H)



IR(CHCl3)2966, 1598, 1517, 1480, 1462, 1368, 1329, 1267,



1177, 1116, 1082, 1032, 970, 907, 867, 808cm−1


I-872
mp 192–194° C.



1H NMR (CDCl3)δ 1.15(t, J=6.9Hz, 3H), 1.76(s, 3H), 1.82(s, 3H),



2.59(s, 3H), 3.69(q, J=6.9Hz, 2H), 3.77(s, 3H), 4.61(d, J=6.9Hz,



2H), 4.99(s, 1H), 5.50(m, 1H), 5.70(s, 1H), 6.84(s, 1H),



6.88–6.97(m, 3H), 7.02(d, J=1.8Hz, 1H), 7.52–7.58(m, 2H)



IR(CHCl3)3536, 2934, 1609, 1520, 1482, 1410, 1365, 1279,



1243, 1172, 1128, 1080, 1029, 972, 952, 872, 833, 812cm−1


I-873
1H NMR (CDCl3)δ 3.46(s, 3H), 3.70(s, 2H), 3.74(s, 3H), 3.75(s,



3H), 5.15(s, 2H), 5.67(s, 1H), 5.90(s, 1H), 6.47(s, 1H), 6.96(d.d,



J=8.4&1.8Hz, 1H), 7.03(d, J=8.4Hz, 1H), 7.09(d, J=1.8Hz, 1H),



7.33–7.44(m, 7H), 7.61(.d, J=8.4Hz, 2H),



IR(KBr)3536, 3389, 1732, 1587, 1519, 1487, 1438, 1393, 1249,



1217, 1166, 1110, 1069, 1001cm−1


I-874
1H NMR (CDCl3)δ 3.46(s, 3H), 3.74(s, 5H), 5.15(s, 2H), 5.68(s,



1H), 5.91(s, 1H), 6.47(s, 1H), 6.96(d.d, J=8.4&1.8Hz, 1H),



7.03(.d, J=8.4Hz, 1H), 7.09(.d, J=8.4Hz, 1H), 7.32–7.49(m, 7H),



7.62(d, J=8.1Hz, 2H)



IR(KBr)3381, 1715, 1698, 1608, 1581, 1523, 1485, 1455, 1396,



1294, 1235, 1112, 1072, 1017cm−1


I-875
1H NMR (CDCl3)δ 2.69(s, 3H), 3.13(s, 3H), 3.54(s, 3H), 3.70(s,



2H), 3.74(s, 3H), 3.77(s, 3H), 5.19(s, 2H), 6.86(s, 1H), 7.15(d,



J=8.7Hz, 1H), 7.30–7.40(m, 9H), 7.59(.d, J=8.1Hz, 2H)



IR(KBr)1734, 1721, 1606, 1481, 1398, 1361, 1244, 1175, 1120,



1078, 1010cm−1

















TABLE 173







I-876
1H NMR (CDCl3)δ 1.76(s, 3H), 1.81(s, 3H), 2.73(s, 3H), 3.23(s,



3H), 3.54(s, 3H), 3.70(s, 2H), 3.74(s, 3H), 3.77(s, 3H), 4.64(d,



J=6.9Hz, 2H), 5.46–5.55(m, 1H), 6.86(s, 1H), 7.09(d, J=8.4Hz,



1H), 7.35(d.d, J=8.4&2.1Hz, 1H), 7.37(d, J=8.1Hz, 2H), 7.39(d,



J=2.1Hz, 1H), 7.59(d, J=8.1Hz, 2H)



1H NMR (CDCl3)δ



IR(KBr)3447, 1735, 1608, 1522, 1482, 1365, 1177, 1117, 1078,



1013cm−1


I-877
1H NMR (CDCl3)δ 1.76(s, 3H), 1.82(s, 3H), 3.46(s, 3H), 3.74(s,



5H), 3H), 4.62(d, J=6.9Hz, 2H), 5.46–5.58(m, 1H), 5.69(s, 1H),



5.89(s, 1H), 6.47(s, 1H), 6.96(s, 2H), 7.06(s, 1H), 7.38(d,



J=8.4Hz, 2H), 7.62(d, J=8.4Hz, 2H)


I-878
1H NMR (CDCl3)δ 1.76(s, 3H), 1.82(s, 3H), 3.46(s, 3H), 3.70(s,



2H), 3.74(s, 6H), 4.62(d, J=6.9Hz, 2H), 5.46–5.58(m, 1H), 5.68(s,



1H), 5.88(s, 1H), 6.47(s, 1H), 6.96(s, 2H), 7.06(s, 1H), 7.37(d,



J=8.4Hz, 2H), 7.61(d, J=8.4Hz, 2H)



IR(KBr)3527, 3386, 1734, 1609, 1586, 1520, 1487, 1439, 1396,



1219, 1167, 1111, 1068, 1010cm−1


I-879
mp 136–139° C.



1H NMR (CDCl3)δ 1.7(brs, 1H), 1.76(s, 3H), 1.81(s, 3H), 2.73(s,



3H), 3.23(s, 3H), 3.53(s, 3H), 3.78(s, 3H), 4.64(d, J=6.7Hz,



2H), 4.78(s, 2H), 5.49(t, J=6.8Hz, 1H), 6.87(s, 1H), 7.09(d,



J=8.6Hz, 1H), 7.35(dd, J=8.6, 2.1Hz, 1H), 7.40(d, J=2.1Hz,



1H), 7.47(s, J=8.1Hz, 2H), 7.64(d, J=8.1Hz, 2H)



IR(KBr)3553, 3434, 1481, 1389, 1363, 1235, 1175, 1084, 1011,



972, 806cm−1


I-880
mp 180–181° C.



1H NMR (CDCl3)δ 1.70(brs, 1H), 1.76(s, 3H), 1.82(s, 3H), 3.46(s,



3H), 3.75(s, 3H), 4.62(d, J=6.9Hz, 2H), 4.77(s, 2H), 5.53(t,



J=6.9Hz, 1H), 5.69(s, 1H), 5.89(s, 1H), 6.47(s, 1H), 6.94–6.96(m,



2H), 7.05–7.07(m, 1H), 7.46(d, J=8.1Hz, 2H), 7.65(d, J=8.4Hz,



2H)



IR(KBr)3509, 3367, 1522, 1487, 1461, 1396, 1289, 1249, 1213,



1116, 1071, 1009, 992, 942, 797, 782cm−1

















TABLE 174







I-881
mp 122–123° C.



1H NMR (CDCl3)δ 1.77(s, 3H), 1.82(s, 3H), 2.34(t, J=6.5Hz, 1H),



3.22(s, 3H), 3.45(s, 3H), 3.73(s, 3H), 4.6(m, 2H), 4.64(d,



J=6.6Hz, 2H), 5.56(t, J=6.6Hz, 1H), 6.84(s, 1H), 6.99–7.10(m,



3H), 7.39(d, J=8.7Hz, 2H), 7.71(d, J=8.7Hz, 2H)



IR(KBr)3579, 1518, 1471, 1360, 1261, 1230, 1148, 1019, 966,



881, 843cm−1


I-882
mp 156–158° C.



1H NMR (CDCl3)δ 1.76(s, 3H), 1.81(s, 3H), 2.49(t, J=6.6Hz, 1H),



3.44(s, 3H), 3.72(s, 3H), 4.49(brs, 2H), 4.63(d, J=6.7Hz, 2H),



5.04(s, 1H), 5.55(t, J=6.7Hz, 1H), 6.85(s, 1H), 6.92(d, J=8.9Hz,



2H), 6.98–7.10(m, 3H), 7.53(d, J=8.9Hz, 2H)



IR(KBr)3433, 3234, 1609, 1520, 1472, 1266, 1227, 994, 836cm−1


I-883
mp 168–170° C.



1H NMR (CDCl3)δ 2.50(t, J=6.5Hz, 1H), 3.44(s, 3H), 3.73(s, 3H),



4.49(brs, 2H), 4.78(d, J=6.1Hz, 2H), 5.06(s, 1H), 6.24(t,



J=6.1Hz, 1H), 6.85(s, 1H), 6.93(d, J=8.6Hz, 2H), 6.97–7.13(m,



3H), 7.53(d, J=8.6Hz, 2H)



IR(KBr)3544, 3412, 3267, 1613, 1521, 1475, 1263, 1229, 1011,



884, 816cm−1


I-884
mp 153–154° C.



1H NMR (CDCl3)δ 3.49(s, 3H), 3.77(s, 3H), 5.17(s, 2H), 5.76(brs,



2H), 6.45(s, 1H), 6.91–7.07(m, 3H), 7.26–7.45(m, 5H), 7.93(d,



J=8.2Hz, 2H), 8.00(brs, 1H), 8.27(d, J=8.4Hz, 2H)



IR(KBr)3448, 2962, 2938, 1738, 1627, 1604, 1589, 1519, 1486,



1319, 1250, 1153, 1115, 1071, 1011cm−1


I-885
mp 81–82° C.



1H NMR (CDCl3)δ 1.51(s, 3H), 1.54(s, 3H), 1.74(s, 3H), 1.77(s,



3H), 2.70(s, 3H), 3.24(s, 3H), 3.60(s, 3H), 3.78(s, 3H), 4.38(d,



J=7.5Hz, 2H), 4.65(d, J=6.6Hz, 2H), 6.86(s, 1H), 7.06–7.11(m,



3H), 7.35–7.41(m, 2H), 7.52–7.57(m, 1H)



IR(KBr)3433, 2938, 1699, 1618, 1521, 1481, 1367, 1209, 1178,



1115, 1081, 972, 950, 813, 793cm−1

















TABLE 175







I-886
mp 208–209° C.



1H NMR (CDCl3)δ 1.77(s, 3H), 1.81(s, 3H), 2.71(s, 3H), 3.23(s,



3H), 3.60(s, 3H), 3.76(s, 3H), 4.64(d, J=7.2Hz, 2H), 5.49(t,



J=8.7Hz, 1H), 6.85(s, 1H), 7.09(d, J=8.7Hz, 1H), 7.26–7.40(m,



3H), 7.52–7.58(m, 1H), 7.69–7.73(m, 1H), 8.02(brs, 1H)



IR(KBr)3357, 2939, 1736, 1606, 1523, 1483, 1398, 1370, 1294,



1243, 1179, 1111, 1079, 965, 827, 814, 795cm−1


I-887
mp 89–90° C.



1H NMR (CDCl3)δ 2.34(s, 3H), 2.38(s, 3H), 2.64(s, 3H), 3.12(s,



3H), 3.53(s, 3H), 3.77(s, 3H), 4.92(s, 2H), 5.14(s, 2H), 6.83(s,



1H), 6.89(d, J=8.7Hz, 2H), 7.11–7.46(m, 12H)



IR(KBr)3434, 2939, 1699, 1617, 1520, 1481, 1367, 1211, 1178,



1114, 1081, 952, 813, 794cm−1


I-888
mp 181–182° C.



1H NMR (CDCl3)δ 2.38(s, 3H), 2.66(s, 3H), 3.12(s, 3H), 3.59(s,



3H), 3.76(s, 3H), 5.14(s, 2H), 6.85(s, 1H), 7.14–7.41(m, 8H),



7.52–7.58(m, 1H), 7.69–7.73(m, 1H), 8.02(brs, 1H)



IR(KBr)3348, 3030, 2940, 1733, 1607, 1523, 1482, 1397, 1366,



1281, 1242, 1212, 1179, 1128, 1112, 1080, 971, 944, 815



799cm−1


I-889
mp 155–157° C.



1H NMR (CDCl3)δ 1.46(t, J=7.0Hz, 3H), 1.76(s, 3H), 1.82(s, 3H),



2.73(s, 3H), 3.23(s, 3H), 3.56(s, 3H), 3.74(s, 3H), 4.46(q,



J=7.4Hz, 2H), 4.65(d, J=7.2Hz, 2H), 5.48–5.54(m, 1H), 6.69(s,



1H), 7.09(d, J=8.4Hz, 2H), 7.28–7.47(m, 4H),



IR(KBr)3434, 2938, 1716, 1579, 1477, 1464, 1409, 1366, 1241,



1178, 1124, 1078, 955, 815, 796cm−1


I-890
mp 82–83° C.



1H NMR (CDCl3)δ 2.67(s, 3H), 3.13(s, 3H), 3.58(s, 3H), 3.80(s,



3H), 5.19(s, 2H), 6.84(s, 1H), 7.13–7.49(m, 8H), 7.89–7.96(m,



2H), 8.27(brs, 1H), 8.27–8.31(m, 1H)



IR(KBr)3447, 3033, 2940, 1743, 1521, 1482, 1367, 1312, 1272,



1249, 1178, 1119, 1080, 957, 817, 799cm−1

















TABLE 176







I-891
mp 86–87° C.



1H NMR (CDCl3)δ 2.68(s, 3H), 3.10(s, 3H), 3.15(s, 3H), 3.62(s,



3H), 3.81(s, 3H), 5.22(s, 2H), 6.85(s, 1H), 7.16–7.50(m, 9H),



7.88–7.94(m, 2H)



IR(KBr)3413, 2938, 1519, 1483, 1366, 1313, 1162, 1119, 1090,



1079, 957, 812cm−1


I-892
mp 97–98° C.



1H NMR (CDCl3)δ 1.53(s, 3H), 1.55(s, 3H), 1.76(s, 3H), 1.78(s,



3H), 3.63(s, 3H), 3.75(s, 3H), 4.26(d, J=7.4Hz, 2H), 4.62(d,



J=6.8Hz, 2H), 5.65(brs, 1H), 5.72(brs, 1H), 6.84(s, 1H),



7.04–7.13(m, 3H), 7.35–7.43(m, 2H), 7.51–7.58(m, 1H)



IR(KBr)3453, 3379, 2973, 2931, 1719, 1629, 1529, 1490, 1406,



1313, 1288, 1247, 1193, 1101, 1072, 1015, 993, 816, 786cm−1


I-893
mp 89–90° C.



1H NMR (DMSO-d6)δ 1.75(s, 3H), 1.78(s, 3H), 3.31(s, 3H),



3.62(s, 3H), 4.56(d, J=6.9Hz, 2H), 5.52(t, J=6.0Hz, 1H), 6.33(s,



1H), 6.34–6.47(m, 2H), 6.74(brs, 2H), 6.74–6.75(m, 1H),



6.87–6.91(m, 1H), 7.11–7.12(m, 1H), 7.32–7.34(m, 1H),



8.52(brs, 1H), 8.75(brs, 1H)



IR(KBr)3424, 2933, 2614, 1719, 1625, 1585, 1523, 1488, 1408,



1287, 1247, 1125, 1070, 819, 788cm−1


I-894
mp 167–168° C.



1H NMR (CDCl3)δ 2.31(s, 3H), 2.38(s, 3H), 3.52(s, 3H), 3.76(s,



3H), 4.91(s, 2H), 5.13(s, 2H), 5.65(brs, 1H), 5.77(brs, 1H), 6.85(s,



1H), 6.84–6.93(m, 2H), 7.10–7.44(m, 12H)



IR(KBr)3425, 2933, 2614, 1719, 1625, 1585, 1522, 1488, 1408,



1287, 1247, 1125cm−1


I-895
mp 93–94° C.



1H NMR (DMSO-d6)δ 2.11(s, 3H), 3.34(s, 3H), 3.62(s, 3H),



5.10(s, 2H), 6.32(s, 2H), 6.41–6.49(m, 2H), 6.65(d, J=9.3Hz, 1H),



6.78(s, 1H), 6.95(d, J=8.7Hz, 1H), 7.09–7.14(m, 1H), 7.22(d,



J=8.4Hz, 2H), 7.41(d, J=8.1Hz, 2H), 8.49(brs, 1H), 8.87(brs, 1H)



IR(KBr)3424, 2932, 1717, 1626, 1585, 1523, 1488, 1409, 1248,



1125, 1106, 1070, 811, 793cm−1

















TABLE 177







I-896
mp 149–150° C.



1H NMR (DMSO-d6)δ 1.72(s, 3H), 1.77(s, 3H), 3.32(s, 3H),



3.55(s, 3H), 3.76(s, 6H), 4.55(d, J=6.3Hz, 2H), 5.50(t, J=6.6Hz,



1H), 6.15(s, 1H), 6.68(d, J=2.1Hz, 1H), 6.91(d, J=8.7Hz, 1H),



7.30(s, 2H), 8.41(brs, 1H), 8.74(brs, 1H),



IR(KBr)3423, 2936, 1694, 1578, 1459, 1410, 1319, 1229, 1126,



1067cm−1


I-897
mp 107–108° C.



1H NMR (CDCl3)δ 2.70(s, 3H), 3.12(s, 3H), 3.55(s, 3H), 3.72(s,



3H), 3.78(s, 6H), 5.18(s, 2H), 6.65(s, 1H), 6.70(d, J=4.2Hz,



1H), 7.14(d, J=8.4Hz, 1H), 7.26–7.48(m, 9H)



IR(KBr)3434, 2941, 1517, 1488, 1366, 1353, 1261, 1177, 1102,



1074, 844, 818, 796cm−1


I-898
powder



1H NMR (CDCl3)δ 1.63(s, 3H), 1.70(s, 3H), 3.48(s, 3H),



3.73–3.76(m, 7H), 3.87(s, 3H), 4.98(s, 1H), 5.24–5.32(m, 2H),



5.90(s, 1H), 6.47(s, 1H), 6.89–7.02(m, 5H), 7.51–7.57(m, 2H)



IR(KBr)3447, 2930, 1612, 1523, 1488, 1455, 1398, 1230, 1120,



1080, 1037, 818, 592cm−1


I-899
mp 171–173° C.



1H NMR (CDCl3)δ 1.73(s, 3H), 1.76(s, 3H), 3.48(s, 3H),



3.73–3.76(m, 5H), 4.23(s, 1H), 4.92(s, 1H), 5.37–4.53(m, 1H),



5.84(s, 1H), 6.46(s, 1H), 6.70(d, J=8.1Hz, 1H), 6.86–7.01(m, 5H),



7.51–7.56(m, 2H)



IR(KBr)3392, 2934, 1612, 1526, 1489, 1398, 1222, 1116, 1075,



829, 590cm−1


I-900
mp 78–79° C.



1H NMR (CDCl3)δ 2.14(s, 3H), 2.29(s, 3H), 2.36(s, 3H), 3.16(s,



3H), 3.20(s, 3H), 5.22(s, 2H), 7.10(s, 1H), 7.16(d, J=8.7Hz,



1H), 7.22–7.49(m, 11H)



IR(CHCl3)2939, 1612, 1516, 1476, 1415, 1370, 1291, 1269,



1174, 1150, 1119, 1087, 1018, 971, 954, 873cm−1

















TABLE 178







I-901
mp 114–116° C.



1H NMR (CDCl3)δ 1.08–1.14(m, 6H), 1.77(s, 3H), 1.81–1.82(d,



J=0.6Hz, 3H), 2.53–2.65(m, 4H), 3.21(s, 3H), 3.23(s, 3H),



4.62–4.65(d, J=6.6Hz, 2H), 5.52(m, 1H), 7.04–7.13(m, 2H),



7.23–7.26(m, 2H), 7.32–7.42(m, 5H)



IR(CHCl3)2970, 2934, 2874, 1674, 1614, 1572, 1517, 1487,



1415, 1370, 1331, 1288, 1262, 1172, 1149, 1109, 971, 937, 872,



849cm−1


I-902
mp 97–99° C.



1H NMR (CDCl3)δ 1.07–1.14(m, 6H), 1.77(s, 3H), 1.83(s, 3H),



2.55–2.66(m, 4H), 4.61–4.64(d, J=6.6Hz, 2H), 5.06(s, 1H),



5.54(m, 1H), 5.77(s, 1H), 7.24–7.64(m, 4H), 6.97(d, J=2.1Hz,



1H), 7.10–7.12(d, J=5.7Hz, 2H), 7.23–7.26(m, 2H),



IR(CHCl3)3596, 3537, 2969, 2933, 27873, 1675, 1612, 1586,



1520, 1489, 1385, 1327, 1290, 1257, 1171, 1125, 996, 903, 877,



836cm−1


I-903
mp 69–71° C.



1H NMR (CDCl3)δ 1.78(s, 3H), 1.82(s, 3H), 2.15(s, 3H), 2.30(s,



3H), 2.43(s, 3H), 2.43(s, 3H), 3.21(s, 3H), 3.27(s, 3H),



4.64–4.67(d, J=6.9Hz, 2H), 5.50(s, 2H), 7.10–7.13(d, J=9.9Hz,



2H), 7.23–7.29(m, 2H), 7.34–7.42(m, 5H)



IR(CHCl3)2939, 1612, 1516, 1476, 1415, 1370, 1331, 1290,



1268, 1174, 1150, 1119, 1086, 971, 954, 873cm−1


I-904
mp 125–127° C.



1H NMR (CDCl3)δ 2.27(s, 6H), 3.91(s, 3H), 4.88(br, 1H), 5.20(s,



2H), 6.83–6.96(m, 5H), 7.12–7.13(d, J=4.5Hz, 2H),



7.22–7.50(m, 7H)



IR(CHCl3)3596, 2957, 2936, 1611, 1586, 1522, 1490, 1464,



1454, 1326, 1257, 1172, 1138, 1033, 835cm−1


I-905
mp 145–146° C.



1H NMR (CDCl3)δ 2.26(s, 3H), 2.28(s, 3H), 3.20(s, 3H), 3.91(s,



3H), 5.21(s, 2H), 6.83(dd, J=8.1, 2.1Hz, 1H), 6.91–6.96(m, 2H),



7.11(s, 1H), 7.15(s, 1H), 7.32–7.50(m, 9H)



IR(CHCl3)2938, 1604, 1584, 1519, 1488, 1464, 1454, 1373,



1330, 1260, 1175, 1149, 1033, 1018, 970, 873, 847cm−1

















TABLE 179







I-906
mp 132–134° C.



1H NMR (CDCl3)δ 2.27(s, 3H), 2.87,(s, 3H), 3.91(s, 3H), 5.16(s,



2H), 5.21(s, 2H), 5.70(s, 1H), 6.82–6.86(m, 2H), 6.92–7.00(m,



4H), 7.13(s, 2H), 7.32–7.50(m, 10H)



IR(CHCl3)3542, 2936, 2871, 1585, 1519, 1491, 1454, 1382,



1322, 1273, 1175, 1137, 1014, 897, 877, 857cm−1


I-907
mp 181–182° C.



1H NMR (CDCl3)δ 1.77(s, 3H), 1.82(s, 3H), 2.13(s, 3H), 2.30(s,



3H), 2.35(s, 3H), 4.61–4.64(d, J=6.9Hz, 2H), 5.37(s, 1H),



5.51(m, 1H), 5.78(s, 1H), 6.81(dd, J=8.1, 2.1Hz, 1H),



6.86–6.97(m, 3H), 7.08(s, 1H), 7.19–7.22(m, 2H), 7.26(s, 1H)



IR(CHCl3)3595, 3536, 2936, 1613, 1587, 1519, 1479, 1453,



1359, 1330, 1279, 1246, 1173, 1127, 1085, 1024, 974, 950, 881,



867cm−1


I-908
mp 167–168° C.



1H NMR (CDCl3)δ 1.77–1.78(d, J=0.9Hz, 3H), 1.84(s, 3H),



2.08(s, 3H), 2.15(s, 3H), 4.63–4.65(d, J=6.9Hz, 2H), 4.82(s,



1H), 5.05(s, 1H), 5.55(m, 1H), 5.80(m, 1H), 6.74(s, 1H), 6.78(dd,



J=8.4, 2.1Hz, 1H), 6.87–6.95(m, 3H), 7.00(d, J=8.4Hz, 1H),



7.23–7.26(m, 2H)



IR(CHCl3)3594, 3534, 2923, 2869, 1675, 1613, 1584, 1520,



1488, 1455, 1399, 1289, 1247, 1166, 1127, 1091, 994, 948,



835cm−1


I-909
mp 170–172° C.



1H NMR (DMSO.d6)δ 1.72(s, 3H), 1.76(s, 3H), 3.31(s, 3H),



3.63(s, 3H), 4.54(d, J=6.5Hz, 2H), 5.17(s, 2H), 5.49(t, J=6.5Hz,



1H), 6.36(s, 1H), 6.63(d, J=8.4Hz, 2H), 6.63(dd, J=8.4, 2.1Hz,



1H), 6.88(d, J=8.4Hz, 1H), 7.31(d, J=8.4Hz, 2H), 8.40(s, 1H),



8.70(s, 1H)



IR(KBr)3416, 3329, 1614, 1523, 1489, 1408, 1242, 1219, 1115,



1070, 997, 817, 787cm−1

















TABLE 180







I-910
mp 207–209° C,



1H NMR (CDCl3)δ 1.54(s, 9H), 2.69(s, 3H), 3.12(s, 3H), 3.52(s,



3H), 3.77(s, 3H), 5.18(s, 2H), 6.56(s, 1H), 6.85(s, 1H), 7.14(d,



J=8.7Hz, 1H), 7.32–7.48(m, 9H), 7.57(d, J=8.7Hz, 2H)



IR(KBr)3373, 1734, 1525, 1369, 1227, 1177, 1158, 1080, 816,



793cm−1


I-911
mp 214–216° C.



1H NMR (DMSO-d6)δ 2.84(s, 3H), 3.33(s, 3H), 3.46(s, 3H),



3.75(s, 3H), 5.26(s, 2H), 5.30(s, 2H), 6.66(d, J=8.7Hz, 2H),



6.93(s, 1H), 7.24–7.45(m, 8H), 7.52(m, 2H)



IR(KBr)3468, 3386, 1604, 1523, 1482, 1392, 1361, 1175, 1085,



815cm−1


I-912
mp 2l5–218° C.



1H NMR (CDCl3)δ 2.67(s, 3H), 3.13(s, 3H), 3.53(s, 3H), 3.78(s,



3H), 5.19(s, 2H), 6.86(s, 1H), 7.15(d, J=8.4Hz, 1H),



7.32–7.48(m, 7H), 7.69(s, 4H), 8.02(brs, 1H)



IR(KBr)3307, 1733, 1482, 1393, 1361, 1284, 1177, 1084, 1012,



967, 945, 816cm−1


I-913
mp 203–205° C.



1H NMR (CDCl3)δ 1.77(s, 3H), 1.81(s, 3H), 2.71(s, 3H), 3.24(s,



3H), 3.54(s, 3H), 3.79(s, 3H), 4.64(d, J=6.8Hz, 2H), 5.50(t,



J=6.8Hz, 1H), 6.86(s, 1H), 7.09(d, J=8.4Hz, 1H), 7.35(dd,



J=8.4, 2.0Hz, 1H), 7.39(d, J=2.0Hz, 1H), 7.69(s, 4H),



8.01(brs, 1H)



IR(KBr)3311, 1735, 1482, 1393, 1362, 1177, 1083, 976, 945,



818cm−1


I-914
mp 105–107° C.



1H NMR (CDCl3)δ 1.76(s, 3H), 1.80,(s, 3H), 2.27(s, 3H), 2.29(s,



3H), 3.20(s, 3H), 3.89(s, 3H), 4.63–4.65(d, J=6.6Hz, 2H),



5.57(m, 1H), 6.87–6.96(m, 3H), 7.12(s, 1H), 7.17(s, 1H),



7.33–7.43(m, 4H)



IR(CHCl3)2937, 2866, 1604, 1583, 1519, 1488, 1464, 1373,



1331, 1259, 1175, 1149, 1035, 970, 873cm−1

















TABLE 181







I-915
mp 164–165° C.



1H NMR (CDCl3)δ 1.75–1.76(d, J=0.6Hz, 3H), 1.79–1.80(d,



J=0.9Hz, 3H), 2.27(s, 3H), 2.28(s, 3H), 3.89(s, 3H), 4.62–4.65(d,



J=6.6Hz, 2H), 4.78(br, 1H), 5.57(m, 1H), 6.86–6.96(m, 4H),



7.12(s, 1H), 7.15(s, 1H), 7.22–7.27(m, 3H)



IR(CHCl3)3596, 2936, 2865, 1676, 1611, 1584, 1522, 1490,



1464, 1385, 1327, 1257, 1172, 1138, 1100, 1035, 996, 952, 896,



835cm−1


I-916
mp 172–173° C.



1H NMR (CDCl3)δ 1.72(s, 3H), 1.77(s, 6H), 1.81(s, 3H), 2.70(s,



3H), 3.11(s, 3H), 3.24(s, 3H), 3.57(s, 3H), 3.80(s, 3H),



4.06–4.27(m, 2H), 4.64(d, J=7.2Hz, 2H), 5.37–5.50(m, 2H),



6.85(s, 1H), 7.10(d, J=8.6Hz, 1H), 7.32–7.39(m, 2H), 7.52(d,



J=8.4Hz, 1H), 7.84(d, J=9.6Hz, 1H), 7.94(s, 1H)



IR(KBr)3434, 1519, 1482, 1366, 1346, 1308, 1178, 1157, 1120,



1090, 1078, 957, 805cm−1


I-917
mp 78–80° C.



1H NMR (CDCl3)δ 3.47(s, 3H), 3.69(s, 6H), 3.80(s, 6H), 5.14(s,



2H), 5.66(brs, 1H), 5.76(brs, 1H), 6.30(s, 1H), 6.69(d, J=8.2Hz,



2H), 7.02(s, 2H), 7.14(s, 1H), 7.34–7.46(m, 6H)



IR(KBr)3443, 2935, 1614, 1587, 1517, 1470, 1250, 1110, 744cm−1


I-918
mp 83–84° C.



1H NMR (DMSO-d6)δ 3.34(s, 3H), 3.72(s, 3H), 5.13(s, 2H),



5.72(brs, 2H), 6.41(s, 1H), 6.62–6.93(m, 4H), 7.32–7.61(m,



7H), 8.54(brs, 1H), 8.88(brs, 1H)



IR(KBr)3398, 2936, 1731, 1633, 1586, 1521, 1489, 1455, 1432,



1402, 1291, 1216, 1112, 1071cm−1


I-919
mp 74–75° C.



1H NMR (CDCl3)δ 2.02(s, 6H), 3.11(s, 3H), 3.21(s, 3H), 5.02(brs,



1H), 5.18(s, 2H), 6.96(s, 1H), 7.04–7.18(m, 3H), 7.37–7.59(m,



9H)



IR(KBr)3503, 3032, 2937, 1513, 1474, 1365, 1289, 1197, 1175,



1149, 1114, 970, 867, 811cm−1

















TABLE 182







I-920
mp 78–79° C.



1H NMR (CDCl3)δ 1.73(s, 3H), 1.78(s, 6H), 1.83(s, 3H), 3.11(s,



3H), 3.48(s, 3H), 3.77(s, 3H), 4.07–4.29(m, 2H), 4.64(d,



J=6.8Hz, 2H), 5.41–5.55(m, 2H), 5.73(s, 1H), 5.82(s, 1H), 6.47(s,



1H), 6.94–7.05(m, 3H), 7.53(d, J=8.0Hz, 1H), 7.86(d,



J=8.6Hz, 1H), 8.00(s, 1H)



IR(KBr)3449, 2971, 2935, 1519, 1489, 1424, 1338, 1310, 1226,



1152, 1117, 1070, 1059, 773cm−1


I-921
mp 176–177° C.



1H NMR (CDCl3)δ 2.10(s, 3H), 2.18(s, 3H), 2.47(s, 3H), 3.12(s,



3H), 3.23(s, 3H), 5.20(s, 2H), 7.09–7.21(m, 3H), 7.39–7.51(m,



8H), 7.60(d, J=8.4Hz, 2H).



IR(KBr)3433, 3033, 2937, 1516, 1470, 1360, 1291, 1267, 1176,



1150, 1119, 976, 857cm−1


I-922
mp 170–172° C.



1H NMR (DMSO-d6)δ 3.36(s, 3H), 3.66(s, 3H), 4.22(brd,



J=2.5Hz, 2H), 4.50(t, J=4.5Hz, 1H), 4.57(d, J=5.7Hz, 2H),



4.60(d, J=5.7Hz, 2H), 4.97(t, J=5.7Hz, 2H), 5.17(s, 2H), 5.23(t,



J=5.7Hz, 1H), 6.93(s, 1H), 7.04(d, J=8.4Hz, 1H), 7.14(dd,



J=8.4, 2.3Hz, 1H), 7.28–7.37(m, 2H), 7.40–7.45(m, 4H),



7.49–7.53(m, 2H), 7.61(d, J=8.1Hz, 2H)



IR(KBr)3322, 1462, 1385, 1228, 1037, 1006, 750, 700cm−1


I-923
mp 130–132° C.



1H NMR (CDCl3)δ 1.55(s, 9H), 1.62(s, 3H), 2.30(s, 12H), 3.00(s,



6H), 6.73(brs, 1H), 6.78–6.82(m, 2H), 7.07–7.14(m, 4H),



7.24–7.27(m, 2H), 8.07–8.13(m, 2H)



IR(KBr)3600–2800(br), 1732, 1624, 1610, 1583, 1530, 1493,



1366, 1347, 1320, 1236, 1154cm−1


I-924
mp 104–106° C.



1H NMR (CDCl3)δ 2.27(s, 3H), 2.30(s, 3H), 3.00(s, 6H), 3.74(brs,



2H), 6.77–6.85(m, 3H), 6.96(dd, J=1.8, 8.1Hz, 1H), 7.03(dd,



J=2.1, 12.0Hz, 1H), 7.09(s, 1H), 7.13(s, 1H), 7.24–7.29(m, 2H)



IR(KBr)3600–2800(br), 1631, 1608, 1580, 1530, 1487, 1436,



1363, 1233, 1195cm−1

















TABLE 183







I-925
mp100–102° C.



1HNMR(CDCl3)δ 1.75(d, J=0.6Hz, 3H), 1.78(d, J=0.6Hz, 3H),



2.29(s, 3H), 2.30(s, 3H), 3.00(s, 6H), 3.77(d, J=6.6Hz, 2H),



3.87(brs, 2H), 5.37–5.40(m, 1H), 6.71–6.83(m, 3H), 7.00–7.03



(m, 2H), 7.11(s, 1H), 7.13(s, 1H), 7.25–7.29(m, 2H)



IR(KBr)3600–2800(br), 1623, 1610, 1529, 1490, 1441, 1348,



1328, 1253, 1229, 1120, 1065cm−1


I-926
mp178–180° C.



1HNMR(CDCl3)δ 2.27(s, 3H), 2.32(s, 3H), 3.01(s, 6H),



6.78–6.83(m, 2H), 7.10(s, 1H), 7.16(s, 1H), 7.18–7.28(m, 4H),



8.12(brs, 1H), 8.27–8.33(m, 1H)



IR(KBr)3600–2800(br), 1709, 1613, 1532, 1490, 1356, 1283,



1229, 1188, 1167cm−1


I-927
mp154–156° C.



1HNMR(CDCl3)δ 1.94(d, J=1.2Hz, 3H), 2.26(d, J=1.2Hz, 3H),



2.27(s, 3H), 2.31(s, 3H), 3.00(s, 6H), 5.79–5.80(m, 1H), 6.78–6.82



(m, 3H), 7.09–7.16(m, 4H), 7.16–7.24(m, 2H), 8.38–8.44(m, 1H)



IR(KBr)3600–2800(br), 1681, 1665, 1643, 1610, 1528, 1506,



1487, 1442, 1359, 1317, 1237, 1198, 1159cm−1


I-928
mp183–185° C.



1HNMR(CDCl3)δ 1.44(t, J=7.5Hz, 3H), 2.27(s, 3H), 2.31(s, 3H),



3.16–3.23(m, 2H), 6.53(d, J=2.4Hz, 1H), 6.78–6.82(m, 2H), 7.09



(s, 1H), 7.14–7.18(m, 3H), 7.24–7.27(m, 3H), 7.59–7.65(m, 1H)



IR(KBr)3600–2800(br), 1607, 1527, 1491, 1451, 1436, 1359,



1336, 1271, 1222, 1153, 1110cm−1


I-929
mp184–186° C.



1HNMR(CDCl3)δ 2.26(s, 3H), 2.32(s, 3H), 3.01(s, 6H), 6.78–6.83



(m, 2H), 7.10(s, 1H), 7.18(s, 1H), 7.23–7.27(m, 1H), 7.65(dd,



J=1.8, 8.1Hz, 1H), 7.70(d, J=2.1Hz, 1H), 8.19–8.24(m, 1H)



IR(KBr)3600–2800(br), 1721, 1612, 1536, 1490, 1325, 1282,



1242, 1197, 1169, 1123, 1054cm−1

















TABLE 184







I-930
mp212–215° C.



1HNMR(DMSO-d6)δ 2.83(s, 3H), 3.43(s, 3H), 3.45(s, 3H),



3.52(s, 3H), 3.79(s, 3H), 4.87(s, 2H), 7.08(s, 1H), 7.21(d,



J=8.4Hz, 1H), 7.27~7.32(m, 2H), 7.48(d, J=8.7Hz, 2H), 7.74(d,



J=8.7Hz, 2H)



IR(Nujol)1731, 1604, 1519, 1480, 1237, 1174, 1081, 1013, 876,



839, 822, 804cm−1


I-931
mp166–168° C.



1HNMR(CDCl3)δ 3.45(s, 3H), 3.75(s, 3H), 4.67(d, J=9.0Hz, 2H),



6.45(s, 1H), 6.78(t, J=9.0Hz, 1H), 6.92(d, J=8.7Hz, 2H), 6.92(d,



J=8.4Hz, 1H), 6.98(dd, J=8.4, 2.1Hz, 1H), 7.09(d, J=2.1Hz, 1H),



7.53(d, J=8.7Hz, 2H)



IR(Nujol)3399, 1611, 1588, 1523, 1488, 1460, 1224, 1113, 1070,



1012, 939, 825, 813, 795cm−1


I-932
foam



1HNMR(CDCl3)δ 3.45(s, 3H), 3.75(s, 3H), 4.64~4.74(m, 3H),



6.45(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.93(d, J=8.4, Hz, 1H),



6.97(dd, J=8.4, 2.1Hz, 1H), 7.08(d, J=2.1Hz, 1H),



7.53(d, J=8.7Hz, 2H)



IR(Nujol)3570, 3461, 3357, 3180, 1753, 1616, 1596, 1524, 1495,



1408, 1313, 1287, 1264, 1240, 1200, 1114, 1073, 1011, 906,



825cm−1


I-933
mp120–123° C.



1HNMR(CDCl3)δ 1.69(s, 3H), 1.74(s, 6H), 1.80(s, 3H),



3.49(s, 3H), 6.68–3.75(m, 5H), 4.58(d, J=6.6Hz, 2H), 5.31–5.41



(m, 1H), 5.50–5.56(m, 1H), 5.81(s, 1H), 6.46(s, 1H), 6.68–6.74



(m, 2H), 6.85–6.93(m, 3H), 7.50–7.56(m, 2H)



IR(KBr)3460, 2969, 2929, 1609, 1523, 1490, 1398, 1247, 1117,



1078, 1013, 824, 778, 708, 589cm−1


I-934
mp171–173° C.



1HNMR(CDCl3)δ 1.75(s, 3H), 1.80(s, 3H), 3.47(s, 3H),



3.73(s, 3H), 3.81(s, 2H), 4.58(d, J=6.9Hz, 2H), 5.50–5.57(m, 1H),



5.82(s, 1H), 6.44(s, 1H), 6.77–6.94(m, 5H), 7.50–7.55(m, 2H)



IR(KBr)3382, 3320, 2929, 1613, 1523, 1490, 1405, 1262, 1221,



1120, 1067, 1011, 844, 818, 598cm−1

















TABLE 185







I-935
mp220–221° C.



1HNMR(DMSO-d6)δ 1.74(s, 3H), 1.77(s, 3H), 2.08(s, 3H),



3.30(s, 3H), 3.64(s, 3H), 4.64(d, J=7.2Hz, 2H), 5.48–5.54(m, 1H),



6.40(s, 1H), 6.80–6.87(m, 2H), 6.93–7.03(m, 2H), 7.42–7.46



(m, 2H), 7.85(s, 1H), 8.58(s, 1H), 8.96(s, 1H), 9.56(s, 1H)



IR(KBr)3476, 3400, 3322, 2935, 1658, 1610, 1542, 1520, 1487,



1270, 1258, 1225, 1115, 1010, 825, 596cm−1


I-936
mp149–150° C.



1HNMR(CDCl3)δ 1.48(s, 3H), 1.67(s, 3H), 1.76(s, 3H),



1.80(s, 3H), 3.63(s, 3H), 3.74(s, 3H), 4.27(d, J=7.5Hz, 2H),



4.63(d, J=6.6Hz, 2H), 5.01(s, 1H), 5.20–5.28(m, 1H), 5.52–5.60



(m, 1H), 6.66(s, 1H), 6.91(d, J=8.7Hz, 2H), 7.01(t, J=8.7Hz, 1H),



7.10–7.22(m, 2H), 7.48(d, J=8.7Hz, 2H)



IR(KBr)3335, 2936, 1671, 1614, 1596, 1522, 1441, 1403, 1369,



1265, 1233, 1111, 1077, 1008, 945, 832cm−1


I-937
mp122–123° C.



1HNMR(CDCl3)δ 3.44(s, 3H), 3.76(s, 3H), 4.77(d, J=6.3Hz, 2H),



5.05(s, 1H), 6.04(s, 1H), 6.24(t, J=6.3Hz, 1H), 6.45(s, 1H), 6.92



(d, J=8.7Hz, 2H) 7.01(t, J=8.7Hz, 1H), 7.19–7.30(m, 2H), 7.53



(d, J=8.7Hz, 2H)



IR(KBr)3582, 3502, 3237, 2950, 1614, 1524, 1490, 1453, 1403,



1301, 13267, 1231, 1112, 1073, 1019, 881, 827cm−1


I-938
mp143–144° C.



1HNMR(CDCl3)δ 1.79(s, 3H), 1.84(s, 3H), 2.10(s, 3H),



2.17(s, 3H), 2.47(s, 3H), 3.23(s, 3H), 3.24(s, 3H), 4.66(d,



J=6.6Hz, 2H), 5.20–5.55(m, 1H), 7.09–7.16(m, 4H), 7.40(d,



J=8.7Hz, 2H), 7.60(d, J=8.1Hz, 2H)



IR(KBr)3433, 2935, 1513, 1472, 1366, 1188, 1178, 1152, 1117,



974, 857cm−1


I-939
mp80–81° C.



1HNMR(CDCl3)δ 3.47(s, 3H), 3.48(s, 3H), 3.68(s, 3H),



3.81(s, 6H), 4.79(s, 2H), 5.13(s, 2H), 5.14(s, 2H), 5.65(s, 1H),



5.75(s, 1H), 6.28(s, 1H), 6.69(s, 2H), 7.01(s, 2H), 7.14(s, 1H),



7.40–7.45(m, 5H)



IR(KBr)3433, 2937, 1720, 1582, 1508, 1455, 1407, 1285, 1239,



1125, 1069, 1051, 1011cm−1

















TABLE 186







I-940
mp71–72° C.



1HNMR(CDCl3)δ 1.76(s, 3H), 1.81(s, 3H), 2.73(s, 3H),



3.21(s, 3H), 3.55(s, 3H), 3.72(s, 3H), 3.78(s, 6H), 4.63(d,



J=6.8Hz, 2H), 5.46–5.52(m, 1H), 6.65(s, 1H), 6.70(d, J=3.8Hz,



2H), 7.07(d, J=8.4Hz, 1H), 7.34–7.46(m, 3H)



IR(KBr)3433, 2938, 1674, 1609, 1587, 1518, 14732, 1365, 1252,



1178, 1109, 1077, 971, 945, 815, 796cm−1


I-941
mp98–99° C.



1HNMR(CDCl3)δ 1.74(s, 3H), 1.78(s, 3H), 3.50(s, 3H),



3.71(s, 3H), 3.72(d, J=8.1Hz, 2H), 5.35(t, J=7.2Hz, 1H),



5.64(s, 1H), 5.77(s, 1H), 6.43(s, 1H), 7.02–7.15(m, 3H), 7.32–7.41



(m, 2H), 7.49–7.56(m, 1H)



IR(KBr)3408, 2934, 1627, 1529, 1491, 1444, 1405, 1246, 1175,



1102, 1069, 822, 783cm−1


I-942
1HNMR(CDCl3)δ 1.77(s, 3H), 1.82(s, 3H), 2.68(s, 3H),



2.73(s, 3H), 3.25(s, 3H), 3.60(s, 3H), 3.81(s, 3H), 4.65(d,



J=6.3Hz, 2H), 5.44–5.53(m, 1H), 6.87(s, 1H), 7.10(.d, J=8.7Hz,



1H), 7.30–7.47(m, 3H), 7.84(d.d, J=7.8&2.1Hz, 1H), 8.22(d,



J=2.1Hz, 1H)



IR(KBr)1530, 1480, 1362, 1272, 1237, 1179, 1077cm−1


I-943
1HNMR(CDCl3)δ 2.69(s, 3H), 3.12(s, 3H), 3.56(s, 3H),



3.77(s, 3H), 3.84(s, 2H), 5.18(s, 2H), 6.82(s, 1H), 6.84(d,



J=8.1Hz, 1H), 7.14(.d, J=8.4Hz, 1H), 7.21–7.50(m, 9H)



IR(KBr)3466, 3377, 1634, 1583, 1525, 1488, 1461, 1400, 1288,



1245, 1196, 1105, 1069cm−1


I-944
1HNMR(CDCl3)δ 1.76(s, 3H), 1.82(s, 3H), 3.49(s, 3H),



3.75(s, 3H), 4.61(d, J=6.6Hz, 2H), 5.48–5.57(m, 1H), 5.59–5.75



(m, 1H), 5.88(s, 1H), 6.43(s, 1H), 6.83–7.07(m, 4H), 7.21–7.30



(m, 1H), 7.35(d.d, J=12.3&1.8Hz, 2H)



IR(KBr)3465, 3377, 1634, 1525, 1488, 1460, 1400, 1287, 1245,



1195, 1105, 1068cm−1


I-945
1HNMR(CDCl3)δ 2.02(s, 6H), 2.15(s, 3H), 3.20(s, 3H),



5.20(s, 3H), 6.81–6.86(m, 1H), 6.93(d.d, J=10.7&2.1Hz, 1H), 6.97



(s, 1H), 7.04–7.12(m, 1H), 7.31–7.52(m, 9H)



IR(KBr)1513, 1468, 1362, 1295, 1264, 1227, 1193, 1171, 1151,



1003, 965cm−1

















TABLE 187







I-946
1HNMR(CDCl3)δ 2.02(s, 6H), 2.15(s, 3H), 3.20(s, 3H), 5.14(d,



J=3.9Hz, 1H), 6.81–6.86(m, 1H), 6.91(d.d, J=10.1&2.1Hz,



1H), 6.97(s, 1H), 7.04–7.12(m, 1H), 7.30–7.42(m, 4H)



IR(KBr)3414, 1624, 1595, 1518, 1473, 1360, 1294, 1170,



1144, 1120, 1104, 1016 cm−1


I-947
1HNMR(CDCl3)δ 1.77(s, 3H), 1.82(s, 3H), 2.02(s, 6H), 2.16(s,



3H), 3.20 (s, 3H), 4.64(d, J=6.6Hz, 2H), 5.53–5.61(m,



1H), 6.82–7.09(m, 4H), 7.33(d, J=9.0Hz, 2H), 7.39(d,



J=9.0Hz, 2H)



IR(KBr)1514, 1468, 1376, 1294, 1262, 1175, 1152,



992, 968 cm−1


I-948
1HNMR(CDCl3)δ 1.77(s, 3H), 1.82(s, 3H), 2.02(s, 6H), 2.17



(s, 3H), 4.64(d, J=6.6Hz, 2H), 4.81(s, 1H), 5.52–5.60



(m, 1H), 6.82–7.08(m, 6H), 7.22(.d, J=8.7Hz, 2H)



IR(KBr)3568, 3417, 1613, 1517, 1471, 1287, 1261, 1230,



1192, 1132, 1102, 1001 cm−1


I-949
1HNMR(CDCl3)δ 3.02(s, 6H), 3.46(s, 3H), 3.75(s, 3H), 5.18



(s, 2H), 6.03(s, 1H), 6.47(s, 1H), 6.82(d, J=8.7Hz, 2H),



7.03–7.51(m, 8H), 7.55(.d, J=8.7Hz, 2H)



IR(KBr)3502, 1604, 1527, 1488, 1359, 1267, 1233,



1198, 1110, 1070 cm−1


I-950
1HNMR(CDCl3)δ 2.60(s, 3H), 3.03(s, 6H), 3.54(s, 3H), 3.76(s,



3H), 5.21(s, 2H), 6.80(d, J=8.7Hz, 2H), 6.86(s, 1H), 7.03–



7.49(m, 8H), 7.54(.d, J=8.7Hz, 2H)



IR(KBr)1602, 1530, 1483, 1444, 1395, 1366, 1233,



1179, 1078, 1015 cm−1


I-951
1HNMR(CDCl3)δ 2.76(s, 3H), 3.02(s, 6H), 3.54(s, 3H), 3.76(s,



3H), 5.28(s, 1H), 6.81(d, J=9.0Hz, 2H), 6.86(s, 1H),



7.04–7.23(m, 3H), 7.54(d, J=9.0Hz, 2H)



IR(KBr)3375, 1607, 1530, 1483, 1395, 1346, 1292, 1228,



1163, 1077, 1009 cm−1


I-952
1HNMR(CDCl3)δ 1.76(s, 3H), 1.80(s, 3H), 2.71(s, 3H), 3.02(s,



6H), 3.55(s, 3H), 3.76(s, 3H), 4.63(d, J=6.9Hz, 2H),



5.49–5.57(m, 1H), 6.82(d, J=8.7Hz, 2H), 6.86(s, 1H),



7.01–7.23(m, 3H), 7.54(d, J=8.7Hz, 2H)



IR(KBr)1602, 1531, 1484, 1389, 1369, 1258, 1235, 1197,



1176, 1084 cm−1

















TABLE 188







I-953
1HNMR(CDCl3)δ 1.76(s, 3H), 1.80(s, 3H), 3.02(s, 6H),



3.47(s, 3H), 3.75(s, 3H), 4.63(d, J=6.9Hz, 2H), 5.51–5.60(m, 1H),



6.03(s, 1H), 6.47(s, 1H), 6.82(.d, J=8.7Hz, 2H), 6.99–7.08(m, 1H),



7.16–7.29(m, 2H), 7.55(d, J=8.7Hz, 2H)



IR(KBr)3498, 1604, 1528, 1488, 1360, 1266, 1234, 1198, 1110,



1067cm−1


I-954
1HNMR(CDCl3)δ 3.02(s, 6H), 3.47(s, 3H), 3.75(s, 3H),



5.14(s, 1H), 6.03(s, 1H), 6.47(s, 1H), 6.82(d, J=9.0Hz, 2H),



7.02–7.09(m, 1H), 7.15–7.29(m, 2H), 7.55(d, J=9.0Hz, 2H)



IR(KBr)3492, 3383, 1607, 1529, 1488, 1397, 1223, 1103, 1065,



1006cm−1


I-955
1HNMR(CDCl3)δ 2.01(s, 6H), 2.17(s, 3H), 4.75(s, 1H),



5.19(s, 2H), 6.83–7.15(m, 7H), 7.30–7.53(m, 6H)



IR(KBr)3542, 1607, 1579, 1513, 1469, 1263, 1126, 1107,



1015cm−1


I-956
1HNMR(CDCl3)δ 1.76(s, 3H), 1.82(s, 3H), 2.66(s, 3H),



3.50(s, 3H), 3.77(s, 3H), 4.62(d, J=6.4Hz, 2H), 5.48–5.56(m, 1H),



5.71(s, 1H), 5.81(s, 1H), 5.47(s, 1H), 6.90–7.00(m, 2H), 7.04(d,



J=1.8Hz, 1H), 7.42(.d, J=7.8Hz, 2H), 7.82(d.d, J=7.8&1.8Hz, 1H),



8.26(.d, J=1.5Hz, 1H)



IR(KBr)3520, 3419, 1585, 1529, 1506, 1344, 1313, 1290, 1251,



1226, 1118, 1079cm−1


I-957
mp123–126° C.



1HNMR(CDCl3)δ 1.75(s, 3H), 1.78(d, J=0.9Hz, 3H),



3.47(s, 3H), 3.75(s, 3H), 3.87(s, 3H), 3.88(s, 3H), 4.63(d,



J=6.6Hz, 2H), 5.57(m, 1H), 5.92(s, 1H), 6.47(s, 1H), 6.95–7.40



(m, 5H), 7.56–7.62(m, 2H)



IR(CHCl3)3510, 2934, 1608, 1519, 1489, 1461, 1394, 1285,



1243, 1175, 1115, 1075, 1034, 1008, 926, 823cm−1


I-958
mp163–164° C.



1HNMR(CDCl3)δ 1.75(s, 3H), 1.78(s, 3H), 3.61(s, 3H),



3.65(s, 3H), 3.75(s, 3H), 3.88(s, 3H), 4.64(d, J=6.6Hz, 2H),



4.99(s, 1H), 5.58(m, 1H), 6.68(s, 1H), 6.88–6.98(m, 5H),



7.46–7.52(m, 2H)



IR(CHCl3)3592, 2934, 1610, 1517, 1461, 1387, 1237, 1171,



1136, 1111, 1084, 1036, 1012, 830cm−1

















TABLE 189







I-959
mp142–146° C.



1HNMR(CDCl3)δ 1.76(s, 3H), 1.82(s, 3H), 3.47(s, 3H),



3.75(s, 3H), 3.94(s, 3H), 4.61(d, J=6.6Hz, 2H), 5.53(m, 1H),



5.69(s, 1H), 5.70(s, 1H), 5.91(s, 1H), 6.46(s, 1H), 6.94–7.26



(m, 6H)



IR(CHCl3)3526, 2930, 1585, 1520, 1489, 1460, 1399, 1287,



1260, 1110, 1070, 1010, 819cm−1


I-960
mp141–145° C.



1HNMR(CDCl3)δ 2.39(s, 3H), 3.47(s, 3H), 3.94(s, 3H),



5.10(s, 2H), 5.68(s, 1H), 5.69(s, 1H), 5.92(s, 1H), 6.46(s, 1H),



6.93–7.38(m, 6H)



IR(CHCl3)3528, 1585, 1519, 1489, 1460, 1399, 1260, 1110,



1070, 1009, 863cm−1


I-961
mp152–154° C.



1HNMR(CDCl3)δ 2.26(s, 3H), 4.79(br, 1H), 5.19(s, 2H),



6.87–6.90(m, 2H), 7.03–7.15(m, 4H), 7.22–7.26(m, 2H),



7.34–7.50(m, 6H)



IR(CHCl3)3596, 2925, 2869, 1612, 1581, 1523, 1490, 1455,



1383, 1313, 1298, 1259, 1171, 1125, 1100, 1012, 956, 877,



836cm−1


I-962
mp150–151° C.



1HNMR(CDCl3)δ 2.28(s, 3H), 3.90(s, 3H), 4.77–4.79(d,



J=6.0Hz, 2H), 6.26(d, J=6.0Hz, 1H), 6.88–6.91(m, 5H),



7.13–7.14(d, J=2.7Hz, 2H), 7.24–7.27(m, 2H)



IR(CHCl3)3596, 2958, 1732, 1612, 1587, 1522, 1490, 1464,



1325, 1257, 1172, 1139, 1100, 1032, 886, 835cm−1


I-963
mp93–94° C.



1HNMR(CDCl3)δ 2.27(s, 3H), 4.76–4.79(d, J=6.0Hz, 2H),



5.12(br, 1H), 6.24(t, J=6.0Hz, 1H), 6.88–7.15(m, 7H), 7.22–7.26



(m, 2H)



IR(CHCl3)3596, 2925, 2867, 1613, 1583, 1523, 1490, 1458,



1424, 1388, 1258, 1171, 1126, 1100, 1022, 956, 886, 836cm−1

















TABLE 190







I-964
foam



1HNMR(CDCl3)δ 3.47(s, 3H), 3.74(s, 3H), 5.06(s, 1H),



5.15(s, 2H), 5.70(s, 1H), 5.94(s, 1H), 6.46(s, 1H), 6.81–7.50



(m, 12H)



IR(CHCl3)3534, 1609, 1587, 1518, 1504, 1482, 1463, 1455,



1407, 1322, 1290, 1249, 1200, 1112, 1072, 1011cm−1


I-965
foam



1HNMR(CDCl3)δ 3.61(s, 3H), 3.75(s, 3H), 5.16(s, 2H),



5.72(s, 2H), 6.46(s, 1H), 6.83(s, 1H), 6.94(dd, J=2.0, 8.4Hz, 1H),



7.00–7.12(m, 4H), 7.29–7.50(m, 7H)



IR(CHCl3)3531, 1587, 1516, 1498, 1482, 1462, 1455, 1410,



1362, 1308, 1288, 1248, 1202, 1121, 1092, 1070, 1006cm−1


I-966
mp174–175° C.



1HNMR(CDCl3)δ 2.28(s, 3H), 3.38(s, 3H), 3.71(s, 3H),



5.16(s, 2H), 5.68(s, 1H), 5.88(s, 1H), 6.30(s, 1H), 6.98(dd, J=1.8,



8.4Hz, 1H), 7.04(d, J=8.4Hz, 1H), 7.11(d, J=1.8Hz, 1H),



7.22–7.49(m, 9H)



IR(KBr)3516, 3398, 1587, 1516, 1500, 1484, 1453, 1412, 1306,



1285, 1247, 1231, 1202, 1126, 1101, 1072, 1019, 769, 737cm−1


I-967
mp103–104° C.



1HNMR(CDCl3)δ 2.26(s, 6H), 4.61–4.78(m, 3H),



4.84(s, 1H), 6.84–6.92(m, 2H), 6.97–7.16(m, 5H), 7.21–7.27



(m, 2H)



IR(KBr)3409, 1742, 1523, 1489, 1315, 1295, 1259, 1231, 1206,



1193, 1124, 1001, 834, 815cm−1


I-968
mp90–91° C.



1HNMR(CDCl3)δ 1.77(s, 6H), 1.82(d, J=0.9Hz, 6H),



2.27(s, 6H), 4.56(d, J=6.6Hz, 2H), 5.13(d, J=6.6Hz, 2H),



5.49–5.60(m, 2H), 6.94–7.00(m, 2H), 7.01–7.14(m, 5H),



7.25–7.31(m, 2H)



IR(KBr)1608, 1522, 1488, 1378, 1299, 1288, 1273, 1259, 1242,



1196, 1176, 1014, 831, 811, 776cm−1

















TABLE 191







I-969
mp200–203° C.



1HNMR(CDCl3)δ 2.00(s, 3H), 2.25(s, 3H), 3.46(s, 3H),



3.73(s, 3H), 3.83(s, 3H), 5.25(s, 1H), 6.01–6.03(m, 1H),



6.06(s, 1H), 6.45(s, 1H), 6.86–6.90(m, 2H), 7.04–7.14(m, 3H),



7.47–7.52(m, 2H)



IR(KBr)3433, 2937, 1721, 1651, 1523, 1489, 1398, 1264, 1225,



1136, 1071, 1035, 927, 823, 530cm−1


I-970
mp157–160° C.



1HNMR(CDCl3)δ 1.74(s, 3H), 1.80(s, 3H), 2.86(s, 3H),



3.49(s, 3H), 3.75(s, 3H), 4.57(d, J=6.6Hz, 2H), 5.08(s, 1H),



5.50–5.57(m, 1H), 5.82(s, 1H), 6.46(s, 1H), 6.66(d, J=2.1Hz,



1H), 6.73(dd, J=2.1, 8.1Hz, 1H), 6.86–6.94(m, 3H), 7.50–7.56



(m, 2H)



IR(KBr)3392, 2934, 1611, 1523, 1490, 1397, 1242, 1216, 1112,



1074, 1002, 592cm−1


I-971
mp153–155° C.



1HNMR(CDCl3)δ 1.77(s, 3H), 1.82(s, 3H), 2.10(s, 3H),



3.20(s, 3H), 3.21(s, 3H), 3.36(s, 3H), 3.71(s, 3H), 4.63(d,



J=6.9Hz, 2H), 5.52(t, J=6.9Hz, 1H), 6.73(s, 1H), 7.06(d,



J=8.4Hz, 1H), 7.14(dd, J=8.4, 2.1Hz, 1H), 7.23(d, J=2.1Hz,



1H), 7.36(d, J=8.9Hz, 2H), 7.69(d, J=8.9Hz, 2H)



IR(KBr)1515, 1474, 1365, 1229, 1175, 1151, 1096, 973,



870, 810cm−1


I-972
amorphous



1HNMR(CDCl3)δ 1.77(s, 3H), 1.82(s, 3H), 2.43(s, 3H),



3.44(s, 3H), 3.71(s, 3H), 4.49(d, J=9.9Hz, 2H), 4.62(d, J=6.6Hz,



2H), 4.72(d, J=7.2Hz, 2H), 5.53(t, J=6.6Hz, 1H), 6.86(s, 1H),



6.96(d, J=8.7Hz, 1H), 7.21–7.30(m, 4H), 7.54(d, J=8.1Hz, 2H)



IR(KBr)3599, 1463, 1386, 1081, 1007cm−1

















TABLE 192







I-973
mp83–86° C.



1HNMR(DMSO-d6)δ 1.74(s, 3H), 1.77(s, 3H), 3.36(s, 3H),



3.65(s, 3H), 4.23(d, J=23.1Hz, 2H), 4.48(t, J=4.4Hz, 1H),



4.52(d, J=5.4Hz, 2H), 4.52–4.60(m, 4H), 4.89(t, J=5.6Hz,



1H), 5.22(t, J=5.9Hz, 1H), 5.48(t, J=6.6Hz, 1H), 6.92(s, 1H),



6.96(d, J=8.6Hz, 1H), 7.12(dd, J=8.6, 1.5Hz, 1H), 7.26(d,



J=1.5Hz, 1H), 7.42(d, J=8.0Hz, 2H), 7.61(d, J=8.0Hz, 2H)



IR(KBr)3399, 1464, 1386, 1230, 1005cm−1


I-974
mp177–179° C.



1HNMR(CDCl3)δ 1.31(d, J=6.9Hz, 6H), 2.70(s, 3H),



2.98(sept, J=6.9Hz, 1H), 3.12(s, 3H), 3.54(s, 3H), 3.76(s, 3H),



5.19(s, 2H), 6.87(s, 1H), 7.15(d, J=8.4Hz, 1H), 7.30–7.49(m, 9H),



7.54(d, J=7.8Hz, 2H)



IR(KBr)1512, 1480, 1369, 1176, 1084, 1014, 813, 798cm−1


I-975
mp180–182° C.



1HNMR(CDCl3)δ 1.31(d, J=6.6Hz, 6H), 1.76(s, 3H),



1.81(s, 3H), 2.74(s, 3H), 2.98(sept, J=6.6Hz, 1H), 3.22(s, 3H),



3.54(s, 3H), 3.77(s, 3H), 4.63(d, J=6.7Hz, 2H), 5.49(t, J=6.7Hz,



1H), 6.87(s, 1H), 7.08(d, J=8.4Hz, 1H), 7.31(d, J=8.1Hz, 2H),



7.35(dd, J=8.4, 2.1Hz, 1H), 7.40(d, J=2.1Hz, 1H), 7.54(d,



J=8.1Hz, 2H)



IR(KBr)1520, 1481, 1366, 1177, 1083, 1012, 975, 944, 815,



797cm−1


I-976
mp125–126° C.



1HNMR(CDCl3)δ 1.31(d, J=6.9Hz, 6H), 1.76(s, 3H),



1.82(s, 3H), 2.97(sept, J=6.9Hz, 1H), 3.46(s, 3H), 3.74(s, 3H),



4.61(d, J=7.1Hz, 2H), 5.53(t, J=7.1Hz, 1H), 5.68(s, 1H),



5.91(s, 1H), 6.48(s, 1H), 6.95–6.96(m, 2H), 7.06–7.07(m, 1H),



7.31(d, J=8.0Hz, 2H), 7.57(d, J=8.0Hz, 2H)



IR(KBr)cm−1

















TABLE 193







I-977
foam



1HNMR(CDCl3)δ 2.68(s, 3H), 3.13(s, 3H), 3.20(s, 3H),



3.57(s, 3H), 3.79(s, 3H), 5.19(s, 2H), 6.86(s, 1H), 7.15(d,



J=8.7Hz, 1H), 7.31–7.62(m, 11H)



IR(CHCl3)1517, 1475, 1371, 1227, 1219, 1176, 1117, 1081,



968, 925, 856, 821cm−1


I-978
foam



1HNMR(CDCl3)δ 2.65(s, 3H), 2.94(s, 3H), 3.14(s, 3H),



3.59(s, 3H), 3.76(s, 3H), 5.19(s, 2H), 6.86(s, 1H), 7.16(d,



J=8.7Hz, 1H), 7.33–7.57(m, 11H)



IR(CHCl3)1517, 1477, 1398, 1370, 1268, 1233, 1216, 1177,



1159, 1079, 972, 894, 856, 818cm−1


I-979
foam



1HNMR(CDCl3)δ 1.77(s, 3H), 1.81(s, 3H), 2.69(s, 3H),



2.94(s, 3H), 3.25(s, 3H), 3.60(s, 3H), 3.76(s, 3H), 4.64(d,



J=6.9Hz, 2H), 5.50(m, 1H), 6.86(s, 1H), 7.10(d, J=8.4Hz, 1H),



7.34–7.57(m, 11H)



IR(CHCl3)1517, 1476, 1398, 1369, 1234, 1178, 1159, 1105,



1079, 972, 895, 854, 814, 801cm−1


I-980
foam



1HNMR(CDCl3)δ 1.76(d, J=0.9Hz, 3H), 1.81(d, J=0.9Hz,



3H), 2.71(s, 3H), 3.20(s, 3H), 3.24(s, 3H), 3.57(s, 3H), 3.79(s,



3H), 4.64(d, J=6.6Hz, 2H), 5.49(m, 1H), 6.86(s, 1H), 7.09(d,



J=8.7Hz, 1H), 7.31–7.40(m, 3H), 7.48–7.55(m, 3H)



IR(CHCl3)1517, 1474, 1365, 1269, 1236, 1177, 1140, 1116,



1078, 964, 923, 854, 814cm−1


I-981
mp122–123° C.



1HNMR(CDCl3)δ 1.77(s, 3H), 1.82(d, J=0.4Hz, 3H),



3.62(s, 3H), 3.75(s, 3H), 4.63(d, J=6.6Hz, 2H), 5.53(m, 1H),



5.70(s, 1H), 5.73(s, 1H), 6.46(s, 1H), 6.86(s, 1H), 6.89–7.13



(m, 4H), 7.29–7.46(m, 3H)



IR(KBr)3366, 1587, 1496, 1482, 1462, 1449, 1408, 1371, 1313,



1290, 1245, 1210, 1126, 1093, 1073, 1001, 783, 770cm−1

















TABLE 194







I-982
mp171–172° C.



1HNMR(CDCl3)δ 1.76(s, 3H), 1.82(s, 3H), 3.48(s, 3H),



3.74(s, 3H), 4.61(d, J=6.9Hz, 2H), 4.91(s, 1H), 5.53(m, 1H),



5.70(s, 1H), 5.91(s, 1H), 6.46(s, 1H), 6.86(m, 1H), 6.91–7.02



(m, 2H), 7.06(m, 1H), 7.13(m, 1H), 7.21(m, 1H), 7.32(m, 1H)



IR(KBr)3368, 1585, 1519, 1507, 1484, 1460, 1450, 1403, 1294,



1255, 1237, 1206, 1110, 1072, 1006, 789, 766cm−1


I-983
mp92.5–93° C.



1HNMR(CDCl3)δ 1.77(s, 3H), 1.83(d, J=0.9Hz, 3H),



2.26(s, 3H), 2.27(s, 3H), 4.63(d, J=6.9Hz, 2H), 5.13(d, J=3.9Hz,



1H), 5.55(m, 1H), 6.98–7.14(m, 8H)



IR(CHCl3)3578, 2922, 1618, 1522, 1490, 1383, 1282, 1120,



979, 873, 824cm−1


I-984
mp89–95° C.



1HNMR(CDCl3)δ 1.77(s, 6H), 1.81(d, J=0.9Hz, 6H),



2.27(s, 6H), 4.63(d, J=6.6Hz, 4H), 5.55(m, 2H), 6.98–7.14(m, 8H)



IR(CHCl3)2930, 1576, 1520, 1490, 1382, 1296, 1270, 1127,



987, 874cm−1


I-985
mp74–75° C.



1HNMR(CDCl3)δ 2.16(s, 3H), 2.69(s, 3H), 3.14(s, 3H),



3.20(s, 3H), 3.56(s, 3H), 5.20(s, 2H), 7.16–7.49(m, 11H),



7.65–7.68(m, 2H)



IR(CHCl3)2939, 1732, 1613, 1518, 1478, 1454, 1415, 1371,



1331, 1292, 1268, 1176, 1150, 1118, 1088, 1010, 969, 950,



872cm−1


I-986
mp50–52° C.



1HNMR(CDCl3)δ 1.77(s, 3H), 1.82(s, 3H), 2.16(s, 3H),



2.74(s, 3H), 3.20(s, 3H), 3.24(s, 3H), 3.57(s, 3H), 4.64–4.66(d,



J=6.3Hz, 2H), 5.50(m, 1H), 7.10–7.39(m, 6H), 7.66–7.68(m, 2H)



IR(CHCl3)2938, 1613, 1518, 1477, 1370, 1331, 1290, 1267,



1176, 1150, 1117, 1088, 970, 949, 871cm−1

















TABLE 195







I-987
1HNMR(CDCl3)δ 1.59–1.60(d, J=0.6Hz, 3H), 1.70–1.71(d,



J=0.9Hz, 3H), 2.26(s, 3H), 2.28(s, 3H), 2.36(m, 1H), 2.77(m, 1H),



3.20(s, 3H), 3.23(s, 3H), 5.24(m, 1H), 7.12(s, 1H), 7.15(s, 1H),



7.23–7.25(m, 1H), 7.33–7.42(m, 6H)


I-988
mp159–161° C.



1HNMR(CDCl3)δ 1.76(s, 3H), 1.82(s, 3H), 2.12(s, 3H),



3.48(s, 3H), 4.61–4.64(d, J=6.6Hz, 2H), 4.75(br, 1H),



5.54(m, 1H), 5.69(s, 1H), 5.73(s, 1H), 6.77–6.98(m, 6H),



7.51–7.54(m, 2H)



IR(CHCl3)3595, 3529, 2937, 1613, 15787, 1522, 1489, 1455,



1401, 1310, 1289, 1173, 1127, 1095, 1009, 939, 835cm−1


I-989
mp126–128° C.



1HNMR(CDCl3)δ 2.25(s, 3H), 3.78(s, 3H), 5.16(s, 2H),



5.75(br, 1H), 6.83–6.89(m, 4H), 6.98–7.00(m, 2H), 7.17(s, 1H),



7.40–7.47(m, 7H)



IR(CHCl3)3596, 3543, 2937, 1610, 1588, 1523, 1493, 1465,



1455, 1388, 1328, 1315, 1262, 1173, 1126, 1038, 1012, 835cm−1


I-990
mp87–90° C.



1HNMR(CDCl3)δ 1.59–1.60(d, J=0.6Hz, 3H), 1.72–1.73



(d, J=0.9Hz, 3H), 2.26(s, 3H), 2.28(s, 3H), 2.34–2.37(m, 2H),



2.66–2.71(m, 2H), 4.84–4.86(br, 2H), 5.28(m, 1H), 6.79(d,



J=1.5Hz, 1H), 6.86–6.89(m, 3H), 7.11–7.17(m, 3H), 7.23–7.26



(m, 2H)



IR(CHCl3)3598, 2925, 2859, 1612, 1569, 1521, 1488, 1450,



1425, 1414, 1328, 1257, 1171, 1101, 958, 836cm−1


I-991
mp174–176° C.



1HNMR(CDCl3)δ 2.26(s, 3H), 3.13(s, 3H), 3.18(s, 3H),



3.80(s, 3H), 5.19(s, 2H), 6.84(s, 1H), 7.13(d, J=8.4Hz, 1H),



7.18(s, 1H), 7.28–7.50(m, 9H), 7.59–7.62(m, 2H)



IR(CHCl3)2940, 1732, 1613, 1520, 1490, 1465, 1455, 1415,



1371, 1331, 1291, 1260, 1173, 1149, 1111, 1038, 1018, 1003,



971, 872, 813cm−1

















TABLE 196







I-992
mp135–137° C.



1HNMR(CDCl3)δ 1.77–1.78(d, J=0.9Hz, 3H), 1.82–1.83(d,



J=0.6Hz, 3H), 2.26(s, 3H), 3.18(s, 3H), 3.24(s, 3H), 3.80(s, 3H),



4.64(d, J=6.6Hz, 2H), 5.52(m, 1H), 6.84(s, 1H), 7.07(d, J=8.7Hz,



1H), 7.18(s, 1H), 7.25–7.35(m, 4H), 7.59–7.62(m, 2H)



IR(CHCl3)3596, 3539, 2937, 1610, 1587, 1523, 1492, 1464,



1454, 1388, 1328, 1315, 1292, 1261, 1173, 1126, 1038, 996,



834cm−1


I-993
mp131–133° C.



1HNMR(CDCl3)δ 1.77(s, 3H), 1.83(s, 3H), 2.26(s, 3H),



3.78(s, 3H), 4.61–4.64(d, J=6.9Hz, 2H), 5.17(br, 1H),



5.35(m, 1H), 5.78(br, 1H), 6.83–6.99(m, 6H), 7.17(s, 1H),



7.44–7.47(m, 2H)



IR(CHCl3)3596, 3539, 2937, 1610, 1587, 1523, 1492, 1464,



1454, 1388, 1328, 131, 1292, 1261, 1173, 1126, 1038, 996,



834cm−1


I-994
mp127–130° C.



1HNMR(CDCl3)δ 1.73(d, J=0.9Hz, 3H), 1.76(d, J=0.9Hz,



3H), 2.99(s, 6H), 3.73–3.76(m, 2H), 3.78(s, 6H), 3.88(s, 3H),



5.37–5.40(m, 1H), 5.83(d, J=7.8Hz, 1H), 6.78–6.84(m, 2H),



6.95(s, 1H), 6.96(s, 1H), 7.06–7.12(m, 2H), 7.48–7.53(m, 2H)


I-995
mp91–93° C.



1HNMR(CDCl3)δ 1.78(s, 3H), 1.84(s, 3H), 2.02(s, 6H),



4.63(d, J=6.4Hz, 2H), 5.07(s, 1H), 5.15(s, 1H), 5.55(t, J=7.0Hz,



1H), 6.63(dd, J=2.0, 8.2Hz, 1H), 6.77(d, J=2.0Hz, 1H), 6.93–6.99



(m, 4H), 7.39(d, J=8.6Hz, 2H)



IR(KBr)3423, 2921, 1611, 1518, 1474, 1282, 1244, 1205, 1125,



1089, 995, 837, 815, 785cm−1


I-996
mp185–186° C.



1HNMR(CDCl3)δ 1.32(t, J=7.5Hz, 3H), 2.71(q, J=7.5Hz, 2H),



3.46(s, 3H), 3.76(s, 3H), 5.15(s, 2H), 5.69(s, 1H), 5.89(s, 1H),



6.94–7.08(m, 3H), 7.37–7.46(m, 5H), 7.54–7.59(m, 2H), 7.82



(brs, 1H), 7.93(d, J=8.1Hz, 1H)



IR(KBr)3504, 3269, 2968, 2936, 1708, 1532, 1518, 1487, 1311,



1286, 1193, 1121, 1071, 1014cm−1

















TABLE 197







I-997
mp77–78° C.



1HNMR(CDCl3)δ 1.73(s, 3H), 1.77(s, 3H), 1.82(s, 3H),



2.70(s, 3H), 3.25(s, 3H), 3.55(s, 3H), 3.82(s, 3H), 4.65(d,



J=6.9Hz, 2H), 4.94(d, J=7.5Hz, 2H), 5.31(t, J=8.7Hz, 1H),



5.50(t, J=6.6Hz, 1H), 6.87(s, 1H), 7.10(d, J=8.4Hz, 1H),



7.28–7.39(m, 3H), 7.87(d, J=8.1Hz, 1H), 7.99(s, 1H)



IR(KBr)3431, 2939, 1702, 1518, 1483, 1368, 1308, 1204, 1177,



1121, 1092, 1079, 957, 804cm−1


I-998
mp144–145° C.



1HNMR(CDCl3)δ 1.76(s, 3H), 1.82(s, 3H), 3.48(s, 3H),



3.69(s, 3H), 3.80(s, 6H), 4.61(d, J=6.9Hz, 2H), 5.51(t, J=4.8Hz,



1H), 5.66(brs, 1H), 5.76(brs, 1H), 6.30(s, 1H), 6.69(d, J=8.1Hz,



2H), 6.93–7.01(m, 2H), 7.11(d, J=2.1Hz, 1H), 7.31–7.37



(m, 1H)



IR(KBr)3476, 2936, 1589, 1517, 1500, 1472, 1408, 1288, 1249,



1111cm−1


I-999
mp82–83° C.



1HNMR(CDCl3)δ 2.71(s, 3H), 3.15(s, 3H), 3.48(s, 3H),



3.56(s, 3H), 3.72(s, 3H), 3.80(s, 6H), 4.66(s, 2H), 4.79(s, 2H),



5.19(s, 2H), 6.69(s, 1H), 7.14–7.17(m, 1H), 7.36–7.49(m, 8H)



IR(KBr)3434, 2939, 1719, 1613, 1581, 1508, 1463, 1396, 1365,



1294, 1272, 1238, 1177, 1122, 1078, 814cm−1


I-1000
mp85–86° C.



1HNMR(CDCl3)δ 1.31(t, J=7.5Hz, 3H), 2.66(s, 3H),



2.71(q, J=7.6Hz, 2H), 3.13(s, 3H), 3.55(s, 3H), 3.78(s, 3H),



5.19(s, 2H), 6.85(s, 1H), 7.15(d, J=8.8Hz, 1H), 7.33–7.59



(m, 4H), 7.85(brs, 1H), 7.94(d, J=8.4Hz, 1H)



IR(KBr)3432, 2939, 1727, 1519, 1480, 1365, 1237, 1165, 1079,



959, 803cm−1


I-1001
mp105–106° C.



1HNMR(CDCl3)δ 1.76(s, 6H), 1.79(s, 3H), 1.82(s, 3H),



3.49(s, 3H), 3.75(s, 3H), 3.81(d, J=6.6Hz, 2H), 4.62(d, J=7.2Hz,



2H), 5.37(t, J=6.3Hz, 1H), 5.53(t, J=6.9Hz, 1H), 5.68(brs, 1H),



5.87(brs, 1H), 6.82(d, J=8.4Hz, 1H), 6.95(s, 2H), 7.05(s, 1H),



7.26(s, 1H), 7.69(dd, J=2.1, 8.4Hz, 1H), 7.75(brs, 1H)



IR(KBr)3459, 2934, 1622, 1582, 1525, 1493, 1467, 1327, 1240,



1139, 1113, 1070, 817cm−1

















TABLE 198







I-1002
mp89–91° C.



1HNMR(CDCl3)δ 2.70(s, 3H), 3.12(s, 3H), 3.55(s, 3H),



3.71(s, 3H), 3.79(s, 6H), 4.77(s, 2H), 5.18(s, 2H), 6.69(s, 2H),



7.14(d, J=8.8Hz, 1H), 7.38–7.52(m, 8H)



IR(KBr)3440, 2939, 1721, 1612, 1581, 1508, 1463, 1395, 1364,



1238, 1178, 1120, 1078, 962, 814, 523cm−1


I-1003
mp196–197° C.



1HNMR(CDCl3)δ 2.26(s, 3H), 3.48(s, 3H), 3.76(s, 3H),



5.16(s, 2H), 5.69(brs, 1H), 5.83(brs, 1H), 6.44(s, 1H), 6.93–7.05



(m, 4H), 7.26–7.45(m, 6H), 7.84(d, J=8.1Hz, 1H), 7.92(s, 1H),



8.29(brs, 1H)



IR(KBr)3407, 2934, 1672, 1589, 1524, 1459, 1425, 1400, 1316,



1288, 1213, 1119, 1057, 1006, 745cm−1


I-1004
mp80–81° C.



1HNMR(CDCl3)δ 1.29(t, J=7.5Hz, 3H), 1.72(s, 3H),



1.76(s, 6H), 1.81(s, 3H), 2.70(s, 3H), 2.71(q, J=7.5Hz, 2H),



3.24(s, 3H), 3.50(s, 3H), 3.81(s, 3H), 4.64(d, J=6.3Hz, 2H),



4.72–4.76(m, 2H), 5.31(t, J=6.9Hz, 1H), 5.50(t, J=6.3Hz,



1H), 6.87(s, 1H), 7.08–7.12(m, 2H), 7.34–7.41(m, 3H), 7.61



(s, 1H)



IR(KBr)3434, 2974, 2938, 1694, 1517, 1480, 1366, 1237, 1202,



1177, 1080, 972, 807, 523cm−1


I-1005
mp157–158° C.



1HNMR(CDCl3)δ 1.31(t, J=7.8Hz, 3H), 1.77(s, 3H),



1.81(s, 3H), 2.71(s, 3H), 2.71(q, J=7.8Hz, 2H), 3.24(s, 3H),



3.55(s, 3H), 3.78(s, 3H), 4.64(d, J=6.6Hz, 2H), 5.50(t, J=8.1Hz,



2H), 6.85(s, 1H), 7.09(d, J=8.4Hz, 1H), 7.33–7.38(m, 2H), 7.52



(d, J=8.1Hz, 1H), 7.58(s, 1H), 7.84(brs, 1H), 7.94(d, J=8.1Hz,



1H)



IR(KBr)3434, 3350, 2938, 1727, 1523, 1480, 1368, 1248, 1178,



1165, 1080, 972, 816, 802, 522cm−1


I-1006
mp91–93° C.



1HNMR(CDCl3)δ 1.30(t, J=7.5Hz, 3H), 1.75(s, 6H),



1.79(s, 3H), 1.81(s, 3H), 2.55(q, J=7.5Hz, 2H), 3.48(s, 3H),



3.74(s, 3H), 3.79(d, J=6.3Hz, 2H), 4.61(d, J=6.6Hz, 2H), 5.41



(t, J=6.0Hz, 1H), 5.53(t, J=6.9Hz, 1H), 5.67(brs, 1H), 5.94



(brs, 1H), 6.48(s, 1H), 6.72(d, J=8.4Hz, 1H), 6.95(s, 2H), 7.07



(s, 1H), 7.37–7.45(m, 2H), 7.64(d, J=7.5Hz, 1H),



IR(KBr)3433, 2932, 1609, 1521, 1489, 1461, 13958, 1308,



1286, 1245, 1192, 1114, 1072, 1011, 811cm−1

















TABLE 199







I-1007
mp71–72° C.



1H NMR (CDCl3)δ 1.31 (t, J=7.5Hz, 3H), 1.76 (s, 3H), 1.82 (s,



3H), 2.60 (q, J=7.2Hz, 2H), 3.47 (s, 3H), 3.75 (s, 3H), 4.61 (d,



J=6.6Hz, 2H), 5.53 (t, J=6.9Hz, 2H), 5.69 (brs, 1H), 5.93 (brs,



1H), 6.47 (s, 1H), 6.78 (d, J=8.1Hz, 1H), 6.95 (s, 2H), 7.06 (s,



1H), 7.26 (s, 1H), 7.39 (s, 1H)



IR(KBr) 3436, 2932, 1620, 1584, 1519, 1487, 1459, 1397, 1285,



1242, 1112, 1072, 819 cm−1


I-1008
mp 171–173° C.



1H NMR (CDCl3)δ 3.46 (s, 3H), 3.75 (s, 3H), 5.15 (s, 2H), 5.68



(s, 1H), 5.88 (s, 1H), 6.44 (s, 1H), 6.95 (dd, J=8.4, 1.9Hz, 1H),



7.03 (d, J=8.4Hz, 1H), 7.08 (d, J=1.9Hz, 1H), 7.37–7.48 (m,



7H), 7.59 (d, J=8.4Hz, 2H)



IR (KBr) 3544, 3514, 3462, 1517, 1482, 1388, 1284, 1247,



1089, 1107, 1069, 1006, 938, 822 cm−1


I-1009
mp 180–182° C.



1H NMR (CDCl3)δ 2.68 (s, 3H), 3.13 (s, 3H), 3.53 (s, 3H), 3.77



(s, 3H), 5.19 (s, 2H), 6.83 (s, 1H), 7.15 (d, J=8.4Hz, 1H), 7.32–



7.49 (m, 9H), 7.57 (d, J=8.7Hz, 2H)



IR (KBr) 1518, 1478, 1370, 1177, 1085, 1012, 813, 797 cm−1


I-1010
mp 128–130° C.



1H NMR (CDCl3)δ 1.76 (s, 3H), 1.82 (s, 3H), 3.46 (s, 3H), 3.75



(s, 3H), 4.62 (d, J=7.0Hz, 2H), 5.53 (t, J=7.0Hz, 1H), 5.69 (s,



1H), 5.85 (s, 1H), 6.44 (s, 1H), 6.93 (dd, J=8.4, 1.6Hz, 1H),



6.97 (d, J=8.4Hz, 1H), 7.05 (d, J=1.6Hz, 1H), 7.42 (d, J=8.4Hz,



2H), 7.59 (d, J=8.4Hz, 2H)



IR (KBr) 1517, 1482, 1287, 1244, 1106, 1070, 1013, 822, 783



cm−1


I-1011
mp 138–140° C.



1H NMR (CDCl3)δ 1.76 (s, 3H), 1.81 (s, 3H), 2.72 (s, 3H), 3.23



(s, 3H), 3.54 (s, 3H), 3.78 (s, 3H), 4.64 (d, J=6.5Hz, 2H), 5.49



(t, J=6.5Hz, 1H), 6.83 (s, 1H), 7.09 (d, J=8.3Hz, 1H), 7.34 (dd,



J=8.3, 2.0Hz, 1H), 7.43 (d, J=8.6Hz, 2H), 7.57 (d, J=8.6Hz, 2H)



IR (KBr) 1518, 1478, 1369, 1177, 1083, 972, 814, 795 cm−1

















TABLE 200







I-1012
mp 135–138° C.



1H NMR (CDCl3)δ 1.55–1.63 (m, 2H), 1.77 (s, 6H), 1.83 (s,



6H), 4.56 (d, J=6.6Hz, 4H), 5.50–5.58 (m, 2H), 6.96–7.01 (m,



4H), 7.32–7.38 (m, 4H), 7.45 (s, 2H)



IR (KBr) 3339, 2914, 1609, 1520, 1488, 1385, 1289, 1238,



1177, 1000, 834, 651 cm−1


I-1013
mp 202–205° C.



1H NMR (CDCl3 + CD3OD)δ 1.78 (s, 3H), 1.82 (s, 3H), 4.57



(d, J=6.6Hz, 2H), 4.62 (s, 4H), 5.50–5.56 (m, 1H), 6.86–7.00



(m, 4H), 7.24–7.37 (m, 4H), 7.44 (s, 2H)



IR (KBr) 3399, 2974, 2930, 1010, 1522, 1489, 1438, 1383,



1238, 1176, 999, 903, 838, 538 cm−1


I-1014
mp 219–221° C.



1H NMR (CDCl3)δ 2.22 (s, 3H), 2.69 (s, 3H), 3.13 (s, 3H), 3.53



(s, 3H), 3.77 (s, 3H), 5.19 (s, 2H), 6.85 (s, 1H), 7.15 (d, J=8.4



Hz, 1H), 7.32–7.49 (m, 7H), 7.60 (s, 4H)



IR (KBr) 3384, 1701, 1604, 1524, 1482, 1355, 1294, 1176,



1084, 1011, 945, 818 cm−1


I-1015
mp 173–175° C.



1H NMR (DMSO-d6)δ 1.74 (s, 3H), 1.77 (s, 3H), 2.08 (s, 3H),



2.87 (s, 3H), 3.35 (s, 3H), 3.47 (s, 3H), 3.77 (s, 3H), 4.68 (d,



J=6.4Hz, 2H), 5.48 (t, J=6.4Hz, 1H), 7.02 (s, 1H), 7.26–7.29



(m, 3H), 7.57 (d, J=8.7Hz, 2H), 7.70 (d, J=8.7Hz, 2H), 10.07



(s, 1H)



IR (KBr) 3383, 1704, 1235, 1524, 1481, 1360, 1177, 1083, 976,



816 cm−1


I-1016
mp 144–145° C.



1H NMR (CDCl3)δ 1.77 (s, 3H), 1.81 (s, 3H), 2.70 (s, 3H), 3.21



(s, 3H), 3.52 (s, 3H), 3.69 (d, J=1.6Hz, 3H), 4.65 (d, J=6.8Hz,



2H), 5.53 (t, J=6.8Hz, 1H), 7.08 (t, J=8.4Hz, 1H), 7.16 (dd, J=



8.4, 1.8Hz, 1H), 7.20 (dd, J=11.7, 1.8Hz, 1H), 7.41 (d, J=8.8Hz,



2H), 7.59 (dd, J=8.8, 1.4Hz, 2H)



IR (KBr) 1521, 1470, 1368, 1265, 1177, 1151, 1038, 971, 875



cm−1

















TABLE 201







I-1017
mp 196–198° C.



1H NMR (DMSO-d6)δ 1.72 (s, 3H), 1.76 (s, 3H), 2.07 (s, 3H),



3.31 (s, 3H), 3.65 (s, 3H), 4.55 (d, J=6.6Hz, 2H), 5.49 (t, J=6.6



Hz, 1H), 6.43 (s, 1H), 6.65 (dd, J=8.4, 1.9Hz, 1H), 6.73 (d, J=



1.9Hz, 1H), 6.90 (d, J=8.4Hz, 1H), 7.55 (d, J=8.6Hz, 2H), 7.66



(d, J=8.6Hz, 2H), 8.58 (brs, 1H), 8.70 (br s, 1H), 10.02 (s, 1H)



IR (KBr) 3358, 1661, 1596, 1523, 1489, 1396, 1308, 1254,



1227, 1114, 1074 cm−1


I-1018
mp 141–143° C.



1H NMR (CDCl3)δ 1.76 (s, 3H), 1.81 (s, 3H), 3.40 (s, 3H), 3.64



(d, J=0.9Hz, 3H), 4.64 (d, J=6.9Hz, 2H), 4.89 (s, 1H), 5.56 (t,



J=6.9Hz, 1H), 5.70 (s, 1H), 6.94 (d, J=8.7Hz, 2H), 7.06 (t, J=



8.7Hz, 1H), 7.21 (ddd, J=8.4, 2.1, 1.1Hz, 1H), 7.27 (dd, J=12.3,



2.1Hz, 1H), 7.44 (dd, J=8.7, 1.5Hz, 2H)



IR (KBr) 3485, 1523, 1466, 1402, 1266, 1173, 1036, 961, 918,



837, 814 cm−1


I-1019
mp81–82° C.



1H NMR (CDCl3)δ 1.77 (s, 3H), 1.81 (s, 3H), 2.26 (s, 3H), 2.72



(s, 3H), 3.23 (s, 3H), 3.57 (s, 3H), 3.79 (s, 3H), 4.64 (d, J=6.3



Hz, 2H), 5.49 (t, J=6.3Hz, 1H), 6.83 (s, 1H), 7.09 (d, J=8.4Hz,



1H), 7.33–7.39 (m, 2H), 7.48 (s, 1H), 7.82 (d, J=6.0Hz, 1H),



7.88 (s, 1H), 8.32 (brs, 1H)



IR(KBr) 3382, 2939, 1736, 1520, 1483, 1365, 1293, 1178, 1119,



1078, 958, 802, 521 cm−1


I-1020
mp93–94° C.



1H NMR (CDCl3)δ 2.62 (s, 3H), 2.99 (s, 3H), 3.15 (s, 3H), 3.20



(s, 3H), 3.83 (s, 3H), 5.21 (s, 2H), 6.91 (s, 2H), 7.17 (d, J=8.2



Hz, 1H), 7.35–7.48 (m, 8H), 7.63 (d, J=8.4Hz, 2H)



IR(KBr) 3434, 3033, 2938, 1611, 1520, 1479, 1366, 1179, 1151,



1085, 969, 850, 793, 519 cm−1

















TABLE 202







I-1021
mp74–75° C.



1H NMR (CDCl3)δ 1.76 (s, 3H), 1.82 (s, 3H), 3.48 (s, 3H), 3.75



(s, 3H), 4.61 (d, J=6.3Hz, 2H), 5.53 (t, J=5.4Hz, 1H), 5.69 (brs,



1H), 5.86 (brs, 1H), 6.42 (s, 1H), 6.83 (d, J=8.7Hz, 1H), 6.91–



6.98 (m, 2H), 7.04 (s, 1H), 7.62 (d, J=8.7Hz, 1H), 7.73 (s, 1H)



IR(KBr) 3495, 3398, 2935, 1633, 1522, 1487, 1291, 1246, 1112,



1072, 821, 788 cm−1


I-1022
mp76–77° C.



1H NMR (CDCl3)δ 1.77 (s, 3H), 1.82 (s, 3H), 1.84 (s, 3H), 3.52



(s, 3H), 3.78 (s, 3H), 4.63 (d, J=6.9Hz, 2H), 5.53 (t, J=6.6Hz,



1H), 5.74 (brs, 1H), 5.80 (brs, 1H), 6.47 (s, 1H), 6.92–7.00 (m,



2H), 7.04 (s, 1H), 7.38 (d, J=8.1Hz, 1H), 7.93 (d, J=8.1 Hz,



1H), 8.04 (s, 1H)



IR(KBr) 3411, 2934, 1662, 1519, 1488, 1425, 1309, 1245, 1175,



1128, 1071, 1050 cm−1


I-1023
mp81–82° C.



1H NMR (CDCl3)δ 1.77 (s, 3H), 1.81 (s, 3H), 2.66 (s, 3H), 2.99



(s, 3H), 3.18 (s, 3H), 3.25 (s, 3H), 3.82 (s, 3H), 4.64 (d, J=6.6



Hz, 2H), 5.49 (t, J=6.0Hz, 1H), 6.90 (s, 1H), 7.10 (d, J=8.4



Hz, 1H), 7.38–7.43 (m, 3H), 7.62 (d, J=8.8Hz, 1H), 8.02 (s,



1H)



IR(KBr) 3434, 3027, 2938, 1672, 1611, 1520, 1479, 1365, 1179,



1117, 1074, 970, 847, 793, 519 cm−1


I-1024
mp77–79° C.



1H NMR (CDCl3)δ 1.78 (s, 3H), 1.83 (s, 3H), 3.77 (s, 3H), 4.63



(d, J=6.6Hz, 2H), 5.53 (t, J=6.2Hz, 1H), 5.76 (brs, 2H), 6.52 (s,



1H), 6.91–7.02 (m, 6H), 7.46 (d, J=8.4Hz, 2H)



IR(KBr) 3465, 2935, 1613, 1586, 1524, 1487, 1359, 1282, 1245,



1222, 1173, 1157, 1112, 1065, 974, 857, 521 cm−1


I-1025
mp78–79° C.



1H NMR (CDCl3)δ 2.73 (s, 3H), 2.78 (s, 3H), 3.15 (s, 3H), 3.21



(s, 3H), 3.62 (s, 3H), 5.22 (s, 2H), 7.20 (d, J=8.4Hz, 1H), 7.37–



7.44 (m, 10H), 7.68 (d, J=8.8Hz, 2H)



IR(KBr) 3433, 3032, 2939, 1519, 1473, 1366, 1178, 1151, 1004,



966, 870, 847, 795, 524 cm−1

















TABLE 203







I-1026
mp 158–159° C.



1H NMR (CDCl3)δ 1.47 (t, J=6.9Hz, 3H), 2.41 (s, 3H), 3.21



(s, 3H), 3.55 (s, 3H), 3.77 (s, 3H), 4.14 (q, J=6.9Hz, 2H), 5.22



(s, 2H), (3.83 (s, 1H), 6.91 (dd, J=2.1, 8.1Hz, 1H), 6.96–



7.01 (m, 2H), 7.28–7.48 (m, 7H), 7.66–7.72 (m, 2H)



IR (KBr) 1517, 1482, 1392, 1362, 1240, 1194, 1175, 1146,



1084, 963, 878, 797 cm−1


I-1027
mp 106–107° C.



1H NMR (CDCl3)δ 2.27 (s, 6H), 3.87 (s, 3H), 5.20 (s, 2H),



6.93–7.00 (m, 2H), 7.01–7.17 (m, 5H), 7.23–7.52 (m, 7H)



IR (KBr) 1607, 1522, 1490, 1467, 1455, 1383, 1294, 1267,



1246, 1178, 1125, 1028, 1011, 836, 813, 744 cm−1


I-108
mp 162–163° C.



1H NMR (CDCl3)δ 1.45 (t, J=6.9Hz, 3H), 3.46 (s, 3H), 3.74



(s, 3H), 4.15 (q, J=6.9Hz, 2H), 4.98 (s, 1H), 5.19 (s, 2H), 5.91



(s, 1H), 6.45 (s, 1H), 6.88–6.94 (m, 2H), 6.95–7.03 (m, 2H),



7.05 (d, J=1.2Hz, 1H), 7.27–7.41 (m, 3H), 7.45–7.56 (m, 4H)



IR (KBr) 3424, 3343, 1611, 1521, 1488, 1462, 1454, 1400,



1379, 1358, 1317, 1290, 1278, 1262, 1240, 1225, 1201, 1185,



1127, 1110, 1068, 1026, 1007, 828, 731 cm−1


I-1029
mp 73–74° C.



1H NMR (CDCl3)δ 1.77 (s, 3H), 1.82 (s, 3H), 2.27 (s, 6H),



3.86 (s, 3H), 4.63 (d, J=7.2Hz, 2H), 5.56 (m, 1H), 6.92–7.00



(m, 2H), 7.00–7.16 (m, 5H), 7.26–7.34 (m, 2H)



IR (KBr) 1610, 1521, 1489, 1461, 1438, 1297, 1276, 1249,



1231, 1181, 1122, 1028, 985, 835 cm−1


I-1030
mp 86–87° C.



1H NMR (CDCl3)δ 1.46 (t, J=6.9Hz, 3H), 1.75 (s, 3H), 1.79



(d, J=0.9Hz, 3H), 2.54 (s, 3H), 3.21 (s, 3H), 3.56 (s, 3H), 3.78



(s, 3H), 4.12 (q, J=6.9Hz, 2H), 4.63 (d, J=6.3Hz, 2H), 5.53



(m, 1H), 6.84 (s, 1H), 6.93–7.01 (m, 3H), 7.35–7.41 (m, 2H),



7.67–7.73 (m, 2H)



IR (KBr) 1518, 1480, 1449, 1413, 1389, 1366, 1239, 1199,



1180, 1150, 1082, 970, 872, 798 cm−1

















TABLE 204







I-1031
mp 145–146° C.



1H NMR (CDCl3)δ 1.44 (t, J=6.9Hz, 3H), 1.74 (s, 3H), 1.77



(d, J=0.9Hz, 3H), 3.47 (s, 3H), 3.75 (s, 3H), 4.13 (q, J=6.9Hz,



2H), 4.63 (d, J=6.6Hz, 2H), 5.10 (s, 1H), 5.56 (m, 1H), 5.91 (s,



1H), 6.46 (s, 1H), 6.89–6.94 (m, 2H), 6.95–7.03 (m, 3H),



7.50–7.56 (m, 2H)



IR (KBr) 3404, 1611, 1520, 1487, 1464, 1442, 1391, 1358,



1293, 1264, 1237, 1224, 1192, 1112, 1071, 1030, 1002, 831



cm−1


I-1032
mp 142–145° C.



1H NMR (CDCl3)δ 3.13 (s, 3H), 3.21 (s, 3H), 4.63 (s, 2H), 4.65



(s, 2H), 5.19 (s, 2H), 7.15 (d, J=8.4Hz, 1H), 7.33–7.52 (m, 13H)



IR (KBr) 3519, 3422, 3380, 3032, 2933, 1611, 1519, 1487,



1364, 1171, 1148, 1109, 969, 871, 817, 527 cm−1


I-1033
mp 103–106° C.



1H NMR (CDCl3+CD3OD)δ 1.78 (s, 3H), 1.82 (s, 3H), 3.22



(s, 3H), 3.24 (s, 3H), 4.58–4.67 (m, 6H), 5.46–5.54 (m, 1H),



7.09 (d, J=8.4Hz, 1H), 7.33–7.53 (m, 8H)



IR (KBr) 3512, 3414, 3012, 2941, 1612, 1519, 1488, 1362,



1335, 1146, 997, 972, 876, 524 cm−1


I-1034
mp 184–187° C.



1H NMR (CDCl3+CD3OD)δ 1.78 (s, 3H), 1.82 (s, 3H), 4.59–



4.65 (m, 6H), 5.52–5.59 (m, 1H), 6.84–6.98 (m, 5H), 7.23–7.28



(m, 2H), 7.44 (s, 1H), 7.45 (s, 1H)



IR (KBr) 3400, 2931, 1611, 1521, 1491, 1247, 1203, 1009,



987, 834 cm−1


I-1035
mp 95–96° C.



1H NMR (CDCl3)δ 2.27 (s, 6H), 2.41 (s, 3H), 5.19 (s, 2H),



7.02–7.18 (m, 5H), 7.22–7.54 (m, 9H)



IR (KBr) 1522, 1512, 1454, 1377, 1309, 1297, 1274, 1267,



1236, 1125, 1008, 877, 822, 742, 696 cm−1


I-1036
mp 95–96° C.



1H NMR (CDCl3)δ 2.24 (s, 3H), 2.27 (s, 3H), 5.19 (s, 2H),



6.99–7.15 (m, 5H), 7.26–7.52 (m, 9H)



IR (KBr) 1518, 1499, 1482, 1454, 1380, 1300, 1278, 1262,



1227, 1125, 1090, 1021, 1015, 875, 834, 817, 739 cm−1

















TABLE 205







I-1037
mp 58–59° C.



1H NMR (CDCl3)δ 1.77 (d, J=0.6Hz, 3H), 1.81 (d, J=0.9Hz,



3H), 2.27 (s, 6H), 2.41 (s, 3H), 4.63 (d, J=6.6Hz, 2H), 5.56 (m,



1H), 6.98–7.14 (m, 5H), 7.21–7.29 (m, 4H)



IR (KBr) 1520, 1490, 1460, 1444, 1385, 1294, 1271, 1262,



1232, 1125, 1001, 828, 818 cm−1


I-1038
mp 67–68° C.



1H NMR (CDCl3)δ 1.77 (s, 3H), 1.81 (d, J=0.9Hz, 3H), 2.25



(s, 3H), 2.27 (s, 3H), 4.64 (d, J=6.6Hz, 2H), 5.55 (m, 1H),



6.90–7.14 (m, 5H), 7.26–7.32 (m, 2H), 7.36–7.42 (m, 2H)



IR (KBr) 1518, 1500, 1482, 1466, 1309, 1299, 1267, 1229,



1124, 1090, 995, 834 cm−1


I-1039
mp 153–155° C.



1H NMR (CDCl3)δ 3.45 (s, 3H), 3.75 (s, 3H), 4.84 (d, J=4.2



Hz, 2H), 6.43~6.51 (m, 2H), 6.45 (s, 1H), 6.92 (d, J=8.7Hz,



2H), 6.94~7.00 (m, 2H), 7.08 (brs, 1H), 7.53 (d, J=8.7Hz,



2H)



IR (KBr) 3411, 1612, 1588, 1523, 1489, 1288, 1245, 1224,



1113, 1070, 1011, 938, 825 cm−1


I-1040
foam



1H NMR (CDCl3)δ 3.28 (d, J=2.4Hz, 1H), 3.45 (s, 3H), 3.75



(s, 3H), 4.94 (dd, J=6.0, 1.8Hz, 2H), 5.74 (ddt, J=11.1, 2.4, 1.8



Hz, 1H), 6.27 (dt, J=11.1, 6.0Hz, 1H), 6.45 (s, 1H), 6.92 (d, J=



8.7Hz, 2H), 6.94~7.00 (m, 2H), 7.07 (d, J=2.1Hz, 1H), 7.53 (d,



J=8.7Hz, 2H)



IR (KBr) 3433, 3279, 1612, 1588, 1523, 1489, 1286, 1248,



1223, 1113, 1070, 1011, 938, 825 cm−1


I-1041
foam



1H NMR (CDCl3)δ 3.45 (s, 3H), 3.75 (s, 3H), 4.90 (d, J=1.8



Hz, 2H), 5.55 (dd, J=10.8, 2.4Hz, 1H), 5.71 (dd, J=17.7, 2.4 Hz,



1H), 5.85 (ddt, J=17.7, 10.8, 1.8Hz, 1H), 6.45 (s, 1H), 6.92 (d,



J=8.7Hz, 2H), 6.97 (dd, J=8.4, 2.1Hz, 1H), 7.07 (d, J=8.4Hz,



1H), 7.08 (d, J=2.1Hz, 1H), 7.53 (d, J=8.7Hz, 2H)



IR (KBr) 3433, 1612, 1589, 1523, 1489, 1286, 1224, 1192,



1112, 1070, 1002, 937, 825, 815 cm−1

















TABLE 206







I-1042
mp 185–187° C.



1H NMR (CDCl3)δ 1.76 (s, 3H), 1.81 (s, 3H), 2.76 (s, 3H),



3.23 (s, 3H), 3.50 (s, 3H), 3.78 (s, 3H), 4.64 (d, J=6.6Hz, 2H),



5.50 (t, J=6.6Hz, 1H), 6.63 (t, J=2.4Hz, 1H), 6.95 (s, 1H), 7.09



(d, J=8.5Hz, 1H), 7.26–7.29 (m, 1H), 7.37 (dd, J=8.5, 2.1Hz,



1H), 7.42 (d, J=2.1Hz, 1H), 7.45–7.51 (m, 2H), 7.89 (s, 1H),



8.26 (br s, 1H)



IR (KBr) 3418, 1473, 1362, 1177, 1079, 961, 817, 796 cm−1


I-1043
mp 152–154° C.



1H NMR (CDCl3)δ 1.76 (s, 3H), 1.82 (s, 3H), 3.43 (s, 3H),



3.76 (s, 3H), 4.61 (d, J=6.9Hz, 2H), 5.53 (t, J=6.9Hz, 1H), 5.69



(s, 1H), 5.98 (s, 1H), 6.55 (s, 1H), 6.63 (t, J=2.1Hz, 1H), 6.94–



7.01 (m, 2H), 7.10 (d, J=0.9Hz, 1H), 7.25–7.27 (m, 1H), 7.46



(d, J=8.4Hz, 1H), 7.51 (dd, J=8.5, 1.5Hz, 1H), 7.89 (s, 1H),



8.24 (br s, 1H)



IR (CHCl3) 3529, 3480, 1515, 1495, 1407, 1291, 1246, 1107,



1070 cm−1


I-104
mp 127–128° C.



1H NMR (CDCl3)δ 2.45 (s, 3H), 3.52 (s, 3H), 3.77 (s, 3H),



3.91 (s, 3H), 5.22 (s, 2H), 6.84 (s, 1H), 6.91 (dd, J=8.4, 2.1Hz,



1H), 6.79–7.00 (m, 2H), 7.12–7.18 (m, 2H), 7.30–7.47 (m,



5H), 7.59–7.63 (m, 2H)



IR (CHCl3) 2938, 2843, 1606, 1585, 1520, 1483, 1464, 1443,



1390, 1368, 1174, 1141, 1083, 1013, 962, 936, 865, 838 cm−1


I-1045
mp 124–127° C.



1H NMR (CDCl3)δ 2.46 (s, 3H), 3.55 (s, 3H), 3.77 (s, 3H),



3.91 (s, 3H), 5.21 (s, 2H), 5.42 (br, 1H), 6.82 (s, 1H), 6.90 (dd,



J=8.4, 1.8Hz, 1H), 6.97–7.10 (m, 3H), 7.29–7.47 (m, 7H)



IR (CHCl3) 3579, 2938, 1600, 1523, 1484, 1464, 1393, 1368,



1327, 1282, 1174, 1141, 1081, 1036, 1012, 962, 908 cm−1


I-1046
mp 178–180° C.



1H NMR (CDCl3)δ 2.44 (s, 3H), 3.29 (s, 3H), 3.58 (s, 3H),



3.78 (s, 3H), 3.91 (s, 3H), 5.22 (s, 2H), 6.83 (s, 1H), 6.99 (dd,



J=8.1, 2.1Hz, 1H), 6.9714 7.25 (m, 2H), 7.31–7.58 (m, 8H)



IR (CHCl3) 2939, 2840, 1591, 1519, 1483, 1464, 1374, 1331,



1173, 1141, 1116, 1082, 1012, 964, 863 cm−1

















TABLE 207







I-107
mp 98–99° C.



1H NMR (CDCl3)δ 2.35 (s, 3H), 5.22 (s, 2H), 6.59 (t, J F-H=



54.6Hz, 2H), 7.09–7.50 (m, 12H), 7.74–7.75 (d, J=4.5Hz, 2H)



IR (CHCl3) 1752, 1523, 1493, 1384, 1273, 1169, 1133, 1070,



1037, 916, 851 cm−1


I-1048
mp 112–114° C.



1H NMR (CDCl3)δ 1.75–1.76 (d, J=0.6Hz, 3H), 1.78–1.79 (d,



J=0.9Hz, 3H), 2.57 (s, 3H), 3.53 (s, 3H), 3.78 (s, 3H), 3.89 (s,



3H), 4.62–4.64 (d, J=7.5Hz, 2H), 5.54 (s, 1H), 6.84 (s, 1H),



6.96–6.97 (m, 3H), 7.12–7.18 (m, 2H), 7.59–7.64 (m, 2H)



IR (CHCl3) 2938, 1606, 1583, 1519, 1483, 1464, 1443, 1416,



1389, 1368, 1175, 1141, 1083, 1038, 1013, 962, 936, 865, 838



cm−1


I-1049
mp 203–204° C.



1H NMR (CD3OD)δ 4.53 (s, 2H), 4.55 (s, 2H), 5.21 (s, 2H),



6.84–6.88 (m, 2H), 7.12–7.50 (m, 12H)



IR (KBr) 3380, 1611, 1586, 1523, 1490, 1462, 1434, 1380,



1317, 1300, 1258, 1194, 1173, 1128, 1033, 1007, 906, 871, 836,



817, 787, 730, 693, 646 cm−1


I-1050
mp 99–100° C.



1H NMR (CDCl3)δ 1.75 (s, 3H), 1.78–1.79 (d, J=0.9Hz,



3H), 3.46 (s, 3H), 3.75 (s, 3H), 3.88 (s, 3H), 4.62–4.64 (d, J=6.6



Hz, 2H), 5.57 (m, 1H), 5.89 (s, 1H), 6.46 (s, 1H), 6.96–7.02 (m,



3H), 7.12–7.18 (m, 2H), 7.59–7.64 (m, 2H)



IR (CHCl3) 3513, 2938, 1605, 1583, 1490, 1423, 1407, 1392,



1362, 1318, 1269, 1177, 1158, 1140, 1118, 1078, 1038, 1012,



930, 846, 826 cm−1


I-1051
mp 153–154° C.



1H NMR (CDCl3)δ 1.76 (s, 3H), 1.79–1.80 (d, J=0.9Hz, 3H),



2.57 (s, 3H), 3.29 (s, 3H), 3.60 (s, 3H), 3.79 (s, 3H), 3.89 (s,



3H), 4.62–4.64 (d, J=6.6Hz, 2H), 5.54 (m, 1H), 6.84 (s, 1H),



6.96–6.97 (m, 4H), 7.46–7.59 (m, 3H)



IR (CHCl3) 2938, 1592, 1519, 1483, 1464, 1374, 1332, 1239,



1173, 1141, 1116, 1082, 1038, 1011, 965, 864 cm−1

















TABLE 208







I-1052
amorphous



1H NMR (CDCl3)δ 2.12 (s, 3H), 3.47 (s, 3H), 5.15 (s, 2H),



5.82–6.08 (m, 3H), 6.70–6.95 (m, 5H), 7.02 (d, J=8.1Hz, 1H),



7.39–7.52 (m, 7H)



IR (CHCl3) 3597, 3535, 2937, 1731, 1612, 1589, 1522, 1489,



1455, 1401, 1382, 1328, 1309, 1288, 1173, 1128, 1096, 1011,



939, 835 cm−1


I-1053
mp 141–142° C.



1H NMR (CDCl3)δ 1.75 (s, 3H), 1.78–1.79 (d, J=0.9Hz, 3H),



3.49 (s, 3H), 3.76 (s, 3H), 3.89 (s, 3H), 4.62–4.64 (d, J=6.6Hz,



2H), 5.30 (d, J F-H=3.3Hz, 1H), 5.57 (m, 1H), 5.88 (s, 1H),



6.45 (s, 1H), 6.99–7.11 (m, 4H), 7.33 (m, 1H), 7.43 (dd, J=11.7,



2.1Hz, 1H)



IR (CHCl3) 3578, 3514, 1621, 1600, 1583, 1523, 1492, 1464,



1397, 1320, 1279, 1175, 1140, 1116, 1100, 1076, 1038, 1011,



902 cm−1


I-1054
mp 138–140° C.



1H NMR (CDCl3)δ 5.17 (s, 2H), 5.60 (s, 1H), 5.72 (s, 1H),



6.98–7.02 (m, 2H), 7.10–7.14 (m, 3H), 7.18 (s, 1H), 7.35 (s,



1H), 7.37–7.47 (m, 5H), 7.59–7.61 (m, 2H)



IR (KBr) 3600–2800(br), 1590, 1528, 1503, 1483, 1454, 1386,



1294, 1254, 1223, 1187, 1132, 1086, 1009 cm−1


I-1055
mp 176–178° C.



1H NMR (CDCl3)δ 3.13 (s, 3H), 3.32 (s, 3H), 5.19 (s, 2H),



7.16 (d, J=8.7Hz, 1H), 7.37–7.55 (m, 9H), 7.61–7.64 (m, 4H)



IR (KBr) 3600–2800(br), 1611, 1525, 1503, 1469, 1359, 1290,



1244, 1170, 1088, 979 cm−1


I-1056
mp 134–136° C.



1H NMR (CDCl3)δ 1.77 (s, 3H), 1.81 (s, 3H), 3.23 (s, 3H),



3.32 (s, 3H), 4.64 (d, J=6.9Hz, 1H), 5.48–5.54 (m, 1H), 7.10 (d,



J=8.4Hz, 1H), 7.44–7.55 (m, 4H), 7.58–7.65 (m, 4H)



IR (KBr) 3600–2800(br), 1609, 1527, 1504, 1469, 1351, 1289,



1277, 1186, 1171, 1115, 1089, 973 cm−1

















TABLE 209







I-1057
mp 97–100° C.



1H NMR (CDCl3)δ 1.77 (d, J=0.9Hz, 3H), 1.82 (d, J=0.9Hz,



3H), 4.63 (d, J=7.2Hz, 2H), 5.50–5.54 (m, 1H), 5.62 (br s, 1H),



5.74 (br s, 1H), 6.95 (d, J=8.7Hz, 1H), 7.12 (dd, J=2.4, 8.7Hz,



1H), 7.18 (s 1H), 7.24 (d, J=2.4Hz, 1H), 7.36 (s, 1H), 7.42–7.46



(m, 2H), 7.58–7.62 (m, 2H)



IR (KBr) 3600–2800(br), 1599, 1588, 1528, 1482, 1385, 1320,



1289, 1252, 1212, 1193, 1132, 1112, 1084, 1056, 1001 cm−1


I-1058
mp 216–218° C.



1H NMR (DMSO-d6)δ 2.93 (s, 12H), 3.73 (s, 6H), 6.74–6.79



(m, 4H), 6.92 (s, 2H), 7.38–7.43 (m, 4H)



IR (KBr) 3600–2800(br), 1616, 1533, 1496, 1458, 1442, 1387,



1360, 1230, 1202, 1169, 1059, 1035 cm−1


I-1059
mp 122–123° C.



1H NMR (CDCl3)δ 1.74 (d, J=0.6Hz, 3H), 1.78 (d, J=0.6Hz,



3H), 2.26 (s, 3H), 2.29 (s, 3H), 3.77 (d, J=6.9Hz, 2H), 4.83 (br,



1H), 5.36–5.41 (m, 1H), 6.61–6.77 (m, 1H), 6.86–6.91 (m, 2H),



6.99–7.04 (m, 2H), 7.10 (s, 1H), 7.11 (s 1H), 7.21–7.26 (m, 2H)



IR (KBr) 3600–2800(br), 1626, 1608, 1526, 1489, 1428, 1336,



1300, 1252, 1209, 1187 cm−1


I-1060
mp foam



1H NMR (CDCl3)δ 1.74 (s, 3H), 1.77 (s, 3H), 2.27 (s, 3H), 2.31



(s, 3H), 3.76 (d, J=6.6Hz, 2H), 3.86 (s, 3H), 5.38–5.43 (m, 1H),



6.66 (d, J=8.1Hz, 1H), 6.80 (d, J=1.8Hz, 1H), 6.86–6.90 (m,



3H), 7.11 (s, 1H), 7.16 (s 1H), 7.23–7.26 (m, 2H)



IR (CHCl3) 3600–2800(br), 1730, 1611, 1525, 1489, 1455,



1256, 1171, 1137, 1100, 1036 cm−1


I-1061
mp 191–193° C.



1H NMR (CDCl3)δ 3.01 (s, 6H), 3.79 (s, 3H), 3.80 (s, 3H),



6.79–6.83 (m, 2H), 6.92 (s, 1H), 6.98 (s 1H), 7.41–7.51 (m,



4H), 8.12 (br s, 1H), 8.26–8.32 (m, 1H)



IR (KBr) 3600–2800(br), 1712, 1617, 1600, 1536, 1494, 1460,



1446, 1385, 1364, 1290, 1212, 1162, 1057, 1035 cm−1

















TABLE 210







I-1062
mp 240–245° C.



1HNMR(CDCl3)δ 3.82(s, 6H), 6.95(s, 2H), 7.41–7.49(m, 4H),



8.13(brs, 2H), 8.29–8.35(m, 1H)



IR(KBr)3600–2800(br), 1725,



1598, 1544, 1492, 1381, 1294, 1215, 1197, 1165, 1109,



1055, 1033 cm−1


I-1063
1HNMR(CDCl3)δ 1.99(s, 6H), 2.17(s, 3H), 3.21(s, 3H),



5.20(s, 2H), 6.95–7.11(m, 4H), 7.23(d, J=8.7Hz, 2H), 7.33–



7.52(m, 7H)



IR(KBr)1617, 1577, 1513, 1366, 1295, 1267, 1198,



1173, 1149, 1127, 1106 cm−1


I-1064
1HNMR(CDCl3)δ 1.99(s, 6H), 2.17(s, 3H), 3.21(s, 3H), 5.18



(d, J=3.9Hz, 1H), 6.97–7.10(m, 4H), 7.23(d, J=8.7Hz, 2H), 7.37



(d, J=8.7Hz, 2H)



IR(KBr)3442, 1620, 1597, 1519, 1472, 1356,



1279, 1232, 1174, 1147, 1103 cm−1


I-1065
1HNMR(CDCl3)δ 1.78(s, 3H), 1.83(s, 3H), 2.00(s, 6H),



2.19(s, 3H), 3.22(s, 3H), 4.65(d, J=6.3Hz, 2H), 5.52–5.62(m,



1H), 6.96–7.13(m, 4H), 7.24(d, J=8.7Hz, 2H), 7.38(d, J=8.7Hz,



2H)



IR(KBr)1617, 1576, 1514, 1466, 1359, 1297, 1268, 1204,



1151, 1002 cm−1


I-1066
1HNMR(CDCl3)δ 1.77(s, 3H), 1.81(s, 3H), 2.01(s, 6H), 2.18



(s, 3H), 4.63(d, J=6.9Hz, 2H), 4.75(s, 1H), 5.52–5.60(m, 1H),



6.82–7.11(m, 8H)



IR(KBr)3433, 1606, 1517, 1466, 1297, 1269,



1221, 1128, 1107, 1004 cm−1


I-1067
1HNMR(CDCl3)δ :2.25(s, 3H), 2.27(s, 3H), 2.31(s, 3H),



3.20(s, 3H), 4.75(s, 1H), 6.83(d, J=8.4Hz, 1H), 7.05–7.14 (m,



4H), 7.34(d, J=8.4Hz, 2H), 7.42(d, J=8.4Hz, 2H)



IR(KBr)3494, 3435, 1604, 1517, 1488, 1375, 1327, 1199, 1171,



1148, 1118 cm−1


I-1068
1HNMR(CDCl3)δ 1.77(s, 3H), 1.82(s, 3H), 2.25(s, 3H),



2.28(s, 6H), 3.20(s, 3H), 4.58(d, J=6.6Hz, 2H), 5.50–5.58(m,



1H), 6.88(d, J=9.0Hz, 1H), 7.08–7.16(m, 4H), 7.34(d, J=8.7Hz,



2H), 7.42(d, J=8.7Hz, 2H)



IR(KBr)1604, 1513, 1486, 1367,



1238, 1176, 1153, 1131, 1002 cm−1

















TABLE 211







I-1069
1H NMR (CDCl3)δ 1.76 (s, 3H), 1.81 (s, 3H), 2.26 (s, 3H),



2.28 (s, 6H), 4.57 (d, J=6.6Hz, 2H), 4.80 (s, 1H), 5.50–5.58



(m, 1H), 6.85–6.91 (m, 3H), 7.09–7.17 (m, 3H), 7.21–7.28



(m, 3H)



IR (KBr) 3436, 1608, 1518, 1488, 1238, 1130, 1008 cm−1


I-1070
1H NMR (CDCl3)δ : 2.26 (s, 3H), 2.30 (s, 3H), 3.00 (s, 6H),



5.19 (s, 2H), 6.80 (d, J=8.7Hz, 2H), 7.02–7.16 (m, 5H), 7.26 (d,



J=8.7Hz, 2H), 7.33–7.51 (m, 5H)



IR (KBr) 1608, 1527, 1490, 1355, 1297, 1270, 1262, 1231,



1121, 1022 cm−1


I-1071
1H NMR (CDCl3)δ 2.26 (s, 3H), 2.30 (s, 3H), 3.01 (s, 6H),



5.09 (s, 1H), 6.80 (d, J=8.4Hz, 2H), 7.01–7.15 (m, 5H), 7.27



(.d, J=8.4Hz, 2H)



IR (KBr) 3432, 1613, 1590, 1526, 1489, 1307, 1283, 1241,



1138, 1111 cm−1


I-1072
1H NMR (CDCl3)δ : 1.77 (s, 3H), 1.81 (s, 3H), 2.27 (s, 3H),



2.30 (s, 3H), 3.00 (s, 6H), 4.63 (d, J=6.6Hz, 2H), 5.51–5.59 (m,



1H), 6.80 (d, J=8.4Hz, 2H), 6.97–7.16 (m, 5H), 7.27 (d, J=8.14



Hz, 2H)



IR (KBr) 1611, 1528, 1489, 1353, 1297, 1266, 1228, 1122,



1011 cm−1


I-1073
mp 182–184° C.



1H NMR (CDCl3)δ 1.48 (s, 3H), 1.67 (s, 3H), 1.91 (s, 3H),



3.46 (s, 3H), 3.76 (s, 3H), 3.84 (s, 3H), 3.94–4.03 (m, 1H),



4.05–4.59 (m, 1H), 5.23–5.32 (m, 1H), 5.74 (br s, 1H), 6.05 (s,



1H), 6.48 (s, 1H), 6.93–6.99 (m, 2H), 7.04–7.10 (m, 3H), 7.51–



7.56 (m, 3H)



IR (KBr) 3400, 2934, 1625, 1523, 1396, 1227, 1119, 1077,



1036, 826, 589 cm−1


I-1074
mp 153–154° C.



1H NMR (CDCl3)δ 1.74 (s, 3H), 1.78 (s, 3H), 2.30 (s, 3H),



2.31 (s, 3H), 3.75 (d, J=6.6Hz, 2H), 3.86 (s, 3H), 3.87 (s, 3H),



5.37–5.45 (m, 1H), 6.66 (d, J=8.4Hz, 1H), 6.74–6.83 (m, 5H),



6.89 (dd, J=1.8, 8.1Hz, 1H), 7.14 (s, 1H), 7.16 (s, 1H)



IR (KBr) 3408, 3389, 3294, 3210, 2919, 2835, 1528, 1495,



1275, 1208, 1032, 856, 826 cm−1

















TABLE 212







I-1075
mp 168–171° C.



1H NMR (CDCl3)δ 1.74 (s, 6H), 1.77 (s, 6H), 2.31 (s, 6H),



3.75 (d, J=6.9Hz, 4H), 3.86 (s, 6H), 5.37–5.45 (m, 2H), 6.66



(d, J=8.1Hz, 2H), 6.80 (d, J=1.8Hz, 2H), 6.89 (dd, J=1.8, 8.1



Hz, 2H), 7.16 (s, 1H)



IR (KBr) 3423, 2968, 2927, 2912, 2849, 1609, 1526, 1498,



1454, 1261, 1209, 1135, 1030, 855, 803 cm−1


I-1076
mp79–80° C.



1H NMR (CDCl3)δ 2.54 (s, 3H), 3.19 (s, 3H), 3.85 (s, 3H),



5.17 (s, 2H), 5.71 (brs, 1H), 6.93 (d, J=8.1Hz, 1H), 7.01–7.07



(m, 3H), 7.24–7.26 (m, 2H), 7.37–7.43 (m, 7H), 7.66 (d, J=8.7



Hz, 2H)



IR(KBr) 3466, 3029, 2939, 2937, 1610, 1520, 1482, 1365,



1246, 1201, 1175, 1150, 1073, 969, 872, 839, 804 cm−1


I-1077
mp151–152° C.



1H NMR (CDCl3)δ 4.00 (s, 3H), 4.91 (brs, 1H), 5.24 (s, 2H),



6.89 (d, J=8.2Hz, 2H), 7.00 (d, J=8.0Hz, 1H), 7.12–7.47 (m,



10H), 7.71 (d, J=7.4Hz, 1H), 7.89 (s, 1H)



IR(KBr) 3422, 1612, 1526, 1491, 1454, 1329, 1287, 1269,



1248, 1171, 1136, 1103, 1019, 827 cm−1


I-1078
mp173–174° C.



1H NMR (CDCl3)δ 3.13 (s, 3H), 4.92 (brs, 1H), 5.19 (s, 2H),



6.88 (d, J=8.6Hz, 2H), 7.15–7.26 (m, 4H), 7.35–7.59 (m, 7H),



7.69 (d, J=9.4Hz, 1H), 7.86 (s, 1H)



IR(KBr) 3426, 1613, 1527, 1489, 1435, 1361, 1330, 1294,



1243, 1164, 1118, 1070, 978, 821 cm−1


I-1079
mp168–169° C.



1H NMR (CDCl3)δ 3.20 (s, 3H), 3.99 (s, 3H), 5.22 (s, 2H), 6.89



(d, J=8.8Hz, 1H), 7.11–7.15 (m, 2H), 7.31–7.49 (m, 10H), 7.73



(d, J=7.4Hz, 1H), 7.90 (s, 1H)



IR(KBr) 3434, 1603, 1524, 1488, 1369, 1335, 1244, 1178,



1143, 1119, 1006, 871 cm−1

















TABLE 213







I-1080
mp68–69° C.



1H NMR (CDCl3)δ 3.13 (s, 3H), 3.19 (s, 3H), 5.19 (s, 2H), 7.18



(d, J=8.6Hz, 2H), 7.26–7.59 (m, 11H), 7.73 (d, J=9.2Hz, 1H),



7.89 (s, 1H)



IR(KBr) 3431, 3034, 2938, 1613, 1524, 1487, 1367, 1330, 1293,



1242, 1175, 1151, 1118, 970, 872, 828 cm−1


I-1081
mp74–76° C.



1H NMR (CDCl3)δ 1.78 (s, 3H), 1.84 (s, 3H), 3.51 (s, 3H), 4.64



(d, J=5.6Hz, 2H), 5.08 (brs, 2H), 5.49–5.54 (m, 1H), 5.75 (brs,



1H), 5.85 (brs, 1H), 6.14 (s, 1H), 6.89–7.12 (m, 5H), 7.53 (d, J=



8.4Hz, 2H)



IR(KBr) 3444, 2934, 1612, 1523, 1485, 1403, 1360, 1251, 1172,



1006, 971, 837, 527 cm−1


I-1082
mp71–72° C.



1H NMR (CDCl3)δ 2.46 (s, 3H), 3.20 (s, 3H), 3.86 (s, 3H), 3.91



(s, 3H), 5.21 (s, 2H), 6.87–7.03 (m, 3H), 7.11 (s, 1H), 7.24–



7.41 (m, 8H), 7.67 (d, J=8.8Hz, 2H)



IR(KBr) 3434, 3028, 2936, 1609, 1521, 1482, 1365, 1239, 1176,



1074, 969, 869, 804 cm−1


I-1083
mp73–74° C.



1H NMR (CDCl3)δ 2.66 (s, 3H), 3.13 (s, 3H), 3.20 (s, 3H), 3.86



(s, 3H), 5.19 (s, 2H), 7.08 (d, J=1.6Hz, 1H), 7.16 (d, J=8.4Hz,



1H), 7.21–7.28 (m, 2H), 7.37–7.42 (m, 8H), 7.66 (d, J=8.4Hz,



2H)



IR(KBr) 3432, 3031, 2938, 1610, 1523, 1480, 1365, 1176, 1151,



1074, 970, 875, 807, 524 cm−1


I-1084
mp110–111° C.



1H NMR (CDCl3)δ 1.78 (s, 3H), 1.81 (s, 3H), 3.21 (s, 3H), 3.98



(s, 3H), 4.67 (d, J=6.6Hz, 2H), 5.57 (t, J–6.8Hz, 1H), 7.01 (d,



J=8.0Hz, 1H), 7.15–7.21 (m, 2H), 7.28–7.45 (m, 4H), 7.76 (d,



J=7.6Hz, 1H), 7.93 (s, 1H), 8.03 (s, 1H)



IR(KBr) 3434, 3010, 2931, 1524, 1488, 1368, 1336, 1247, 1173,



1149, 1121, 1007, 871, 562 cm−1

















TABLE 214







I-1085
mp147–148° C.



1H NMR (CDCl3)δ 1.76 (s, 3H), 1.79 (s, 3H), 3.96 (s, 3H), 4.65



(d, J=6.3Hz, 2H), 4.91 (brs, 1H), 5.55 (t, J=5.7Hz, 1H), 6.88 (d,



J=8.1Hz, 2H), 6.99 (d, J=8.4Hz, 1H), 7.12–7.26 (m, 4H), 7.36



(d, J=8.1Hz, 1H), 7.89 (s, 1H)



IR(KBr) 3450, 2938, 1612, 1524, 1490, 1436, 1340, 1264, 1230,



1212, 1139, 1123, 984, 835 cm−1


I-1086
mp134–135° C.



1H NMR (CDCl3)δ 1.77 (s, 3H), 1.82 (s, 3H), 4.64 (d, J=6.6Hz,



2H), 4.84 (brs, 1H), 5.52 (t, J=7.2Hz, 1H), 5.77 (s, 1H), 6.87 (d,



J=8.7Hz, 2H), 6.96 (d, J=8.4Hz, 1H), 7.12 (dd, J=2.4, 8.7Hz,



1H), 7.35 (d, J=8.1Hz, 1H), 7.70 (d, J=8.4Hz, 1H), 7.89 (s, 1H)



IR(KBr) 3367, 1610, 1489, 1442, 1333, 1265, 1193, 1165, 1124,



834, 805 cm−1


I-1087
mp156–157° C.



1H NMR (CDCl3)δ 1.78 (s, 3H), 1.81 (s, 3H), 3.82 (s, 3H), 3.89



(s, 3H), 4.65 (d, J=6.2Hz, 2H), 4.95 (brs, 1H), 5.22 (brs, 1H),



5.58 (t, J=6.0Hz, 1H), 6.73 (s, 1H), 6.87–7.00 (m, 6H), 7.53



(d, J=8.4Hz, 2H)



IR(KBr) 3394, 2934, 1610, 1526, 1499, 1455, 1402, 1240, 1221,



1139, 1099, 894, 815 cm−1


I-1088
mp69–70° C.



1H NMR (CDCl3)δ 1.77 (s, 3H), 1.83 (s, 3H), 3.80 (s, 3H), 4.63



(d, J=7.0Hz, 2H), 4.93 (brs, 1H), 5.22 (brs, 1H), 5.52 (t, J=7.0



Hz, 1H), 5.78 (brs, 1H), 6.70 (d, J=1.6Hz, 1H), 6.83–7.01 (m,



6H), 7.51 (d, J=8.8Hz, 2H)



IR(KBr) 3411, 2933, 1611, 1526, 1492, 1453, 1263, 1242, 1220,



1190, 1172, 1096, 907, 822 cm−1


I-1089
mp 160–161° C.



1H NMR (CDCl3)δ 1.39 (d, J=6.0Hz, 6H), 2.40 (s, 3H), 3.21 (s,



3H), 3.55 (s, 3H), 3.77 (s, 3H), 4.55 (m, 1H), 5.20 (s, 2H), 6.83



(s, 1H), 6.93 (dd, J=1.8, 8.1Hz, 1H), 7.01 (d, J=8.1Hz, 1H),



7.01 (d, J=1.8Hz, 1H), 7.28–7.48 (m, 7H), 7.66–7.72 (m, 2H)



IR (KBr) 1515, 1480, 1463, 1391, 1363, 1239, 1192, 1176,



1149, 1082, 1018, 962, 873, 800 cm−1

















TABLE 215







I-1090
mp 154–155° C.



1H NMR(CDCl3)δ 2.59(s, 3H), 3.21(s, 3H), 3.54(s, 3H), 3.77(s,



3H), 5.23(s, 2H), 6.84(s, 1H), 7.06(d, J=8.4Hz, 1H), 7.24–7.50



(m, 9H), 7.65–7.71(m, 2H)



IR(KBr)1513, 1479, 1365, 1267, 1232, 1178, 1150, 1079, 971,



959, 875, 797cm−1


I-1091
mp 137–138° C.



1H NMR(CDCl3)δ 1.38(d, J=6.3Hz, 6H), 3.46(s, 3H), 3.74(s,



3H), 4.54(m, 1H), 4.96(s, 1H), 5.17(s, 2H), 5.92(s, 1H), 6.45(s,



1H), 6.89–6.94(m, 2H), 7.00–7.11(m, 3H), 7.27–7.41(m, 3H),



7.45–7.56(m, 4H)



IR(KBr)3443, 3356, 1611, 1521, 1488, 1458, 1393, 1269, 1236,



1138, 1112, 1074, 1013, 830, 743cm−1


I-1092
mp 75–76° C.



1H NMR(CDCl3)δ 1.37(d, J=5.8Hz, 6H), 1.75(s, 3H), 1.79(s,



3H), 2.53(s, 3H), 3.21(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 4.51(m,



1H), 4.61(d, J=6.6Hz, 2H), 5.52(m, 1H), 6.84(s, 1H), 6.96–7.02



(m, 3H), 7.34–7.42(m, 2H), 7.65–7.74(m, 2H)



IR(KBr)1516, 1480, 1449, 1360, 1332, 1240, 1199, 1177, 1152,



1083, 964, 873, 797cm−1


I-1093
mp 119–120° C.



1H NMR(CDCl3)δ 1.37(d, J=6.3Hz, 6H), 1.73(s, 3H), 1.77(d,



J=0.9Hz, 3H), 3.46(s, 3H), 3.75(s, 3H), 4.51(m, 1H), 4.61(d, J=



6.6Hz, 2H), 5.14(s, 1H), 5.54(m, 1H), 5.93(s, 1H), 6.46(s, 1H),



6.89–6.95(m, 2H), 6.98(d, J=8.1Hz, 1H), 7.01–7.07(m, 2H),



7.50–7.56(m, 2H)



IR(KBr)3426, 1610, 1522, 1488, 1455, 1402, 1267, 1237, 1174,



1135, 1112, 1079, 1020cm−1


I-1094
mp 150–151° C.



1H NMR(CDCl3)δ 3.44(s, 3H), 3.75(s, 3H), 4.90(s, 1H), 5.20(s,



2H), 5.99(s, 1H), 6.44(s, 1H), 6.88–6.95(m, 2H), 7.04(d, J=8.4



Hz, 1H), 7.29–7.44(m, 4H), 7.47–7.56(m, 5H)



IR(KBr)3410, 1610, 1519, 1484, 1463, 1455, 1410, 1382, 1359,



1285, 1264, 1229, 1118, 1074, 1060, 1014, 995cm−1


I-1095
1H NMR(CDCl3)δ 0.96(s, 3H), 0.98(s, 3H), 1.53–1.82(m, 3H),



2.99(s, 6H), 3.20(t, J=7.2Hz, 2H), 3.78(s, 3H), 3.79(s, 3H), 3.87



(br, 1H), 6.71–6.83(m, 3H), 6.92(s, 1H), 6.94(s, 1H), 7.23–7.31



(m, 2H), 7.47–7.52(m, 2H)

















TABLE 216







I-1096
mp 87–89° C.



1H NMR(CDCl3)δ 1.70(s, 3H), 1.75(s, 3H), 2.82(s, 3H), 3.00(s,



3H), 3.74–3.80(m, 2H), 3.78(s, 3H), 3.80(s, 3H), 5.29–5.34(m,



1H), 6.79–6.83(m, 2H), 6.92–6.97(m, 3H), 7.25–7.34(m, 2H),



7.47–7.52(m, 2H)



IR(KBr)3600–2800(br), 1613, 1531, 1495, 1460, 1448, 1380,



1359, 1253, 1210, 1057, 1036cm−1


I-1097
mp 167–169° C.



1H NMR(CDCl3)δ 2.92(s, 3H), 3.00(s, 6H), 3.78(s, 3H), 3.79(s,



3H), 4.02(br, 1H), 6.71–6.83(m, 3H), 6.92(s, 1H), 6.95(s, 1H),



7.25–7.32(m, 2H), 7.47–7.52(m, 2H)



IR(KBr)3600–2800(br), 1625, 1613, 1533, 1497, 1462, 1445,



1381, 1358, 1328, 1262, 1205, 1163, 1051, 1031cm−1


I-1098
mp 114–115° C.



1H NMR(CDCl3)δ 2.27(s, 6H), 2.54(s, 3H), 5.19(s, 2H), 7.00–



7.16(m, 5H), 7.26–7.51(m, 9H)



IR(KBr)1519, 1501, 1483, 1454, 1310, 1295, 1263, 1232, 1123,



998, 744cm−1


I-1099
mp 68–69° C.



1H NMR(CDCl3)δ 1.62(br s, 1H), 1.77(s, 3H), 1.82(s, 3H), 2.27



(s, 3H), 2.28(s, 3H), 4.64(d, J=6.8Hz, 2H), 4.76(s, 2H), 5.56(m,



1H), 7.00–7.16(m, 5H), 7.33–7.48(m, 4H)



IR(KBr)3433, 1522, 1490, 1384, 1311, 1296, 1266, 1232, 1194,



1122, 1025, 1013, 992, 841, 818cm−1


I-1100
mp 68–69° C.



1H NMR(CDCl3)δ 1.62(br s, 1H), 1.77(s, 3H), 1.82(s, 3H), 2.27



(s, 3H), 2.28(s, 3H), 4.64(d, J=6.8Hz, 2H), 4.76(s, 2H), 5.56(m,



1H), 7.00–7.16(m, 5H), 7.33–7.48(m, 4H)



IR(KBr)3433, 1522, 1490, 1384, 1311, 1296, 1266, 1232, 1194,



1122, 1025, 1013, 992, 841, 818cm−1

















TABLE 217







I-1101
mp 171° C.



1H NMR(CDCl3)δ 1.77(s, 3H), 1.81(d, J=0.9Hz, 3H), 2.68(s,



3H), 3.21(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 4.65(d, J=6.6Hz,



2H), 5.53(m, 1H), 6.84(s, 1H), 7.03(d, J=8.7Hz, 1H), 7.29(dd,



J=2.1, 8.7Hz, 1H), 7.36–7.41(m, 2H), 7.46(d, J=2.1Hz, 1H),



7.66–7.72(m, 2H)



IR(KBr)1510, 1477, 1376, 1358, 1349, 1294, 1237, 1196, 1173,



1145, 1077, 1004, 958, 861, 801cm−1


I-1102
mp 168–169° C.



1H NMR(CDCl3)δ 1.76(d, J=0.3Hz, 3H), 1.80(d, J=0.9Hz, 3H),



3.44(s, 3H), 3.75(s, 3H), 4.64(d, J=6.6Hz, 2H), 4.97(s, 1H),



5.55(m, 1H), 6.00(s, 1H), 6.45(s, 1H), 6.89–6.95(m, 2H), 7.01



(d, J=8.4Hz, 1H), 7.33(dd, J=2.1, 8.4Hz, 1H), 7.51(d, J=2.1Hz,



1H), 7.51–7.56(m, 2H)



IR(KBr)3396, 1613, 1521, 1485, 1467, 1440, 1408, 1384, 1357,



1286, 1264, 1229, 1116, 1076, 1056, 993, 834cm−1


I-1103
mp 176–177° C.



1H NMR(CDCl3)δ 1.77(s, 3H), 1.80(s, 3H), 2.09(s, 3H), 2.16(s,



3H), 3.87(s, 3H), 4.65(d, J=7.2Hz, 2H), 4.78(br s, 1H), 5.06(s,



1H), 5.40–5.60(m, 1H), 6.76(s, 1H), 6.82–6.91(m, 4H), 7.02(d,



J=7.8Hz, 1H), 7.22–7.27(m, 2H)



IR(CHCl3)3597, 3533, 3026, 3010, 2921, 1731, 1612, 1520,



1488, 1240, 1172cm−1


I-1104
mp 185–186° C.



1H NMR(CDCl3)δ 1.78(s, 3H), 1.82(s, 3H), 2.06(s, 3H), 2.15(s,



3H), 4.66(d, J=6.9Hz, 2H), 4.71(s, 1H), 4.89(s, 1H), 5.53–5.58



(m, 1H), 6.75(s, 1H), 6.86–6.91(m, 2H), 6.90–7.00(m, 3H),



7.21–7.26(m, 2H)



IR(CHCl3)3691, 3598, 3546, 3068, 2922, 1674, 1613, 1520,



1488, 1298, 1262, 1165cm−1


I-1105
mp 143–144° C.



1H NMR(CDCl3)δ 2.48(s, 3H), 3.21(s, 3H), 3.52(s, 3H), 3.67(d,



J=1.2Hz, 3H), 3.92(s, 3H), 5.23(s, 2H), 6.92–7.02(m, 3H),



7.31–7.48(m, 7H), 7.60(dd, J=8.7, 1.5Hz, 2H)



IR(KBr)1519, 1470, 1370, 1256, 1173, 1152, 1029, 872cm−1

















TABLE 218







I-1106
mp 128–130° C.



1H NMR(CDCl3)δ 1.76(s, 3H), 1.80(s, 3H), 2.59(s, 3H), 3.21(s,



3H), 3.53(s, 3H), 3.67(d, J=0.9Hz, 3H), 3.90(s, 3H), 4.64(d,



J=6.9Hz, 2H), 5.55(t, J=6.9Hz, 1H), 6.97–7.00(m, 3H), 7.41(d,



J=8.8Hz, 2H), 7.60(dd, J=8.8, 1.1Hz, 2H)



IR(KBr)1519, 1361, 1258, 1175, 1148, 1041, 978, 874cm−1


I-117
mp 168–170° C.



1H NMR(CDCl3)δ 1.76(s, 3H), 1.79(s, 3H), 3.43(s, 3H), 3.63(d,



J=0.9Hz, 3H), 3.89(s, 3H), 4.65(d, J=6.8Hz, 2H), 5.01(s, 1H),



5.57(t, J=6.8Hz, 1H), 5.65(s, 1H), 6.90–7.06(m, 5H), 7.43(dd,



J=8.7, 1.5Hz, 2H)



IR(KBr)3433, 1523, 1464, 1397, 1253, 1216, 1038, 977, 838,



814cm−1


I-1108
mp 127–128° C.



1H NMR(CDCl3)δ 2.25(s, 3H), 2.27(s, 3H), 3.20(s, 3H), 5.22(s,



2H), 7.02(d, J=8.4Hz, 1H), 7.10(s, 1H), 7.11(s, 1H), 7.18(dd,



J=2.1, 8.4Hz, 1H), 7.31–7.54(m, 10H)



IR(KBr)1513, 1484, 1369, 1284, 1243, 1175, 1150, 1061, 984,



968, 868, 847, 791, 718cm−1


I-1109
mp 161–162° C.



1H NMR(CDCl3)δ 2.26(s, 3H), 2.28(s, 3H), 5.16(s, 2H), 5.19(s,



2H), 5.70(br s, 1H), 6.82(dd, J=2.1, 8.4Hz, 1H), 6.96–7.16(m,



7H), 7.31–7.51(m, 10H)



IR(KBr)3449, 1521, 1492, 1470, 1455, 1394, 1294, 1279, 1247,



1232, 1199, 1185, 1129, 1013, 740, 695cm−1


I-110
mp 133–134° C.



1H NMR(CDCl3)δ 2.26(s, 6H), 4.80(br s, 1H), 5.21(s, 2H),



6.85–6.93(m, 2H), 7.02(d, J=8.4Hz, 1H), 7.09(s, 1H), 7.17(s,



1H), 7.15–7.52(m, 9H)



IR(KBr)3350, 1601, 1519, 1485, 1453, 1387, 1289, 1255, 1169,



1060, 839, 813, 731cm−1

















TABLE 219







I-1111
mp 83–84° C.



1H NMR(CDCl3)δ 1.78(d, J=0.3Hz, 3H), 1.82(d, J=0.9Hz, 3H),



2.26(s, 3H), 2.27(s, 3H), 3.20(s, 3H), 4.65(d, J=6.6Hz, 2H),



5.55(m, 1H), 6.99(d, J=8.4Hz, 1H), 7.11(s, 1H), 7.12(s, 1H),



7.19(dd, J=2.1, 8.4Hz, 1H), 7.38(d, J=2.1Hz, 1H), 7.32–7.43



(m, 4H)



IR(KBr)1514, 1485, 1364, 1286, 1253, 1197, 1178, 1156, 1057,



976, 882, 851cm−1


I-1112
mp 86–87° C.



1H NMR(CDCl3)δ 1.77(d, J=0.6Hz, 3H), 1.82(d, J=0.9Hz, 3H),



2.27(s, 6H), 4.65(d, J=6.6Hz, 2H), 5.00(s, 1H), 5.55(m, 1H),



6.86–6.92(m, 2H), 6.98(d, J=8.4Hz, 1H), 7.10(s, 1H), 7.11(s,



1H), 7.20(dd, J=2.1, 8.4Hz, 1H), 7.22–7.26(m, 2H), 7.38(d, J=



2.1Hz, 1H)



IR(KBr)3339, 1608, 1530, 1492, 1429, 1362, 1288, 1258, 1232,



1213, 1189, 1112, 889, 783cm−1


I-1113
amorphous



1H NMR(CDCl3)δ 1.76(s, 3H), 3.32(s, 6H), 3.44(s, 3H), 3.74(s,



3H), 5.23(s, 2H), 7.02(s, 1H), 7.14–7.20(m, 2H), 7.28(d, J=8.7



Hz, 1H), 7.32–7.55(m, 7H), 7.72(d, J=8.4Hz, 2H), 9.22(s, 1H)



IR(KBr)3382, 1684, 1518, 1469, 1365, 1237, 1150, 1017, 972,



872, 815cm−1


I-1114
mp 173–175° C.



1H NMR(CDCl3)δ 1.76(s, 3H), 1.81(s, 3H), 1.97(s, 3H), 3.19(s,



6H), 3.21(s, 3H), 3.37(s, 3H), 3.75(s, 3H), 4.62(d, J=6.9Hz,



2H), 5.50(t, J=6.9Hz, 1H), 6.85(m, 2H), 7.06(d, J=8.4Hz, 1H),



7.25(m, 1H), 7.37(br s, 1H), 7.66(d, J=8.7Hz, 2H)



IR(KBr)3421, 1518, 1470, 1366, 115, 1107, 970, 814cm−1

















TABLE 220







I-1115
mp 96–98° C.



1H NMR(DMSO-d6)δ 1.72(s, 3H), 1.77(s, 3H), 3.27(s, 3H),



3.59(s, 3H), 4.21(s, 2H), 4.55(d, J=6.3Hz, 2H), 5.50(t, J=6.3Hz,



1H), 6.17(s, 1H), 6.59(dd, J=8.1, 1.8Hz, 1H), 6.66(d, J=1.8Hz,



1H), 6.82(d, J=8.7Hz, 2H), 6.97(d, J=8.1Hz, 1H), 7.42(d, J=8.7



Hz, 2H), 8.89(br s, 1H), 9.45(br s, 1H)



IR(KBr)3431, 3396, 3319, 1611, 1521, 1486, 1264, 1172, 1111,



987, 826cm−1


I-1116
mp 186–188° C.



1H NMR(DMSO-d6)δ 1.72(s, 3H), 1.76(s, 6H), 3.28(s, 3H),



3.68(s, 3H), 4.54(d, J=6.6Hz, 2H), 5.48(t, J=6.6Hz, 1H), 6.53–



6.58(m, 1H), 6.65(d, J=1.8Hz, 1H), 6.83–6.89(m, 4H), 7.43(d,



J=8.4Hz, 2H), 8.73(br s, 1H), 8.96(br s, 1H), 9.53(br s, 1H)



IR(KBr)3429, 1652, 1611, 1519, 1474, 1250, 1080, 1018, 981,



836cm−1


I-1117
mp 210–213° C.



1H NMR(CDCl3)δ 3.48(s, 3H), 3.77(s, 3H), 5.16(s, 2H), 5.71(s,



1H), 5.85(s, 1H), 6.48(s, 1H), 6.95(dd, J=8.4, 2.1Hz, 1H), 7.04



(d, J=8.4Hz, 1H), 7.07(d, J=2.1Hz, 1H), 7.40–7.48(m, 5H), 7.83



(d, J=9.0Hz, 2H), 8.32(d, J=9.0Hz, 2H)



IR(KBr)3499, 1511, 1343, 1284, 1247, 1195, 1109, 1070,



1013cm−1


I-1118
mp 156–158° C.



1H NMR(CDCl3)δ 2.67(s, 3H), 3.14(s, 3H), 3.56(s, 3H), 3.80(s,



3H), 5.20(s, 2H), 6.87(s, 1H), 7.16(d, J=8.7Hz, 1H), 7.32–7.48



(m, 7H), 7.82(d, J=9.2Hz, 2H), 8.32(d, J=9.2Hz, 2H)



IR(KBr)1518, 1479, 1350, 1177, 1119, 1079, 947, 816cm−1


I-1119
mp 173–175° C.



1H NMR(CDCl3)δ 1.77(s, 3H), 1.81(s, 3H), 2.71(s, 3H), 3.24(s,



3H), 3.57(s, 3H), 3.80(s, 3H), 4.64(d, J=6.7Hz, 2H), 5.50(t, J=



6.7Hz, 1H), 6.87(s, 1H), 7.10(d, J=8.4Hz, 1H), 7.35(d, J=8.4,



2.1Hz, 1H), 7.39(d, J=2.0Hz, 1H), 7.82(d, J=9.0Hz, 2H), 8.32



(d, J=9.0Hz, 2H)



IR(KBr)1519, 1479, 1360, 1178, 1075, 946, 850, 799cm−1

















TABLE 221







I-1120
mp 191–193° C.



1H NMR(CDCl3)δ 1.77(s, 3H), 1.82(s, 3H), 3.48(s, 3H), 3.77(s,



3H), 4.63(d, J=6.6Hz, 2H), 5.53(t, J=6.6Hz, 1H), 5.72(s, 1H),



5.83(s, 1H), 6.48(s, 1H), 6.93(dd, J=8.1, 1.8Hz, 1H), 6.98(d, J=



8.1Hz, 1H), 7.04(d, J=1.8Hz, 1H), 7.83(d, J=9.0Hz, 2H), 8.32



(d, J=9.0Hz, 2H)



IR(KBr)3492, 1588, 1511, 1482, 1345, 1283, 1244, 1116, 1069,



1010cm−1


I-1121
mp 135–138° C.



1H NMR(CDCl3)δ 1.76(s, 3H), 1.82(s, 3H), 3.61(s, 3H), 3.67(s,



3H), 3.73(s, 3H), 4.62(d, J=6.9Hz, 2H), 5.00(br. s, 1H), 5.50–



5.57(m, 1H), 5.69(br. s, 1H), 6.65(s, 1H), 6.86–6.96(m, 4H),



7.00(d, J=1.8Hz, 1H), 7.48(d, J=8.4Hz, 2H)



IR(KBr)3428, 2938, 1680, 1613, 1594, 1520, 1479, 1460, 1393,



1260, 1226, 1104, 1081, 993, 834cm−1


I-1122
mp 140–142° C.



1H NMR(CDCl3)δ 1.78(s, 3H), 1.82(s, 3H), 2.34(s, 3H), 4.65–



4.67(d, J=6.9Hz, 2H), 5.55(m, 1H), 6.41–6.78(dt, J F—H=54.6,



3.3Hz, 2H), 7.05–7.25(m, 5H), 7.26–7.45(m, 2H), 7.75(m, 2H)



IR(CHCl3)1752, 1523, 1493, 1435, 1385, 1301, 1272, 1169,



1132, 1070, 1037, 916, 889cm−1


I-1123
mp 178–180° C.



1H NMR(CDCl3)δ 1.75(s, 3H), 1.78–1.79(d, J=0.6Hz, 3H), 2.13



(s, 3H), 3.50(s, 3H), 3.87(s, 3H), 4.63–4.65(d, J=6.6Hz, 2H),



5.00(br, 1H), 5.57(m, 1H), 5.75(s, 1H), 6.79(s, 1H), 6.84–7.00



(m, 5H), 7.50–7.53(m, 2H)



IR(CHCl3)3596, 3528, 2937, 1612, 1584, 1522, 1489, 1454,



1400, 1259, 1173, 1139, 1102, 1009, 930, 865, 835cm−1


I-1124
mp 173–174° C.



1H NMR(CDCl3)δ 3.03(s, 6H), 3.54(s, 3H), 3.76(s, 3H), 3.91(s,



3H), 5.22(s, 2H), 6.80–6.99(m, 6H), 7.28–7.58(m, 7H)



IR(CHCl3)2938, 1731, 1609, 1527, 1485, 1442, 1394, 1365,



1174, 1141, 1082, 1037, 1013, 961, 936, 863cm−1

















TABLE 222







I-1125
mp 103–106° C.



1H NMR(CDCl3)δ 1.78(s, 3H), 1.82–1.83(d, J=0.9Hz, 3H),



4.65–4.67(d, J=6.9Hz, 2H), 5.55(m, 1H), 6.41–6.78(td, J



F—H=54.9, 2.7Hz, 2H), 6.94–7.31(m, 7H), 7.73(m, 2H)



IR(CHCl3)3592, 1612, 1525, 1495, 1385, 1301, 1263, 1187,



1173, 1132, 1069, 1036, 917, 889, 838cm−1


I-1126
mp 153–155° C.



1H NMR(CDCl3)δ 1.75(s, 3H), 1.78–1.79(d, J=0.9Hz, 3H), 2.58



(s, 3H), 3.03(s, 6H), 3.55(s, 3H), 3.77(s, 3H), 3.88(s, 3H), 4.61–



4.64(d, J=6.9Hz, 2H), 5.54(m, 1H), 6.80–6.97(m, 6H), 7.54–



7.57(d, J=8.7Hz, 2H)



IR(CHCl3)2938, 1609, 1527, 1485, 1464, 1442, 1392, 1365,



1174, 1140, 1082, 1038, 1012, 961, 935cm−1


I-1127
mp 160–161° C.



1H NMR(CDCl3)δ 2.12(s, 3H), 3.49(s, 3H), 3.89(s, 3H), 4.89



(br, 1H), 5.21(s, 2H), 5.76(s, 1H), 6.79–6.92(mm, 5H), 7.00(d,



J=8.4Hz, 1H), 7.31–7.53(m, 7H)



IR(CHCl3)3594, 3517, 2937, 1731, 1612, 1589, 1522, 1489,



1455, 1400, 1327, 1259, 1240, 1173, 1139, 1102, 1011, 930,



865, 835cm−1


I-1128
mp 149–150° C.



1H NMR(CDCl3)δ 1.74–1.75(d, J=0.9Hz, 3H), 1.78–1.79(d,



J=0.9Hz, 3H), 3.03(s, 1H), 3.49(s, 6H), 3.75(s, 3H), 3.88 s, 3H),



4.62–4.64(d, J=6.6Hz, 2H), 5.57(m, 1H), 5.95(s, 1H), 6.49(s,



1H), 6.81–6.84(m, 2H), 6.95–7.03(m, 3H), 7.55–7.58(m, 2H)



IR(CHCl3)3509, 2937, 1675, 1610, 1584, 1528, 1492, 1464,



1397, 1362, 1323, 1197, 1175, 1140, 1117, 1078, 1038, 1011,



929, 835cm−1


I-1129
mp 163–165° C.



1H NMR(CDCl3)δ 2.15(s, 3H), 2.47(s, 3H), 3.20(s, 3H), 3.55(s,



3H), 3.90(s, 3H), 5.22(s, 2H), 6.80(dd, J=8.4, 2.1Hz, 1H), 6.88



(d, J=2.1Hz, 1H), 7.00(d, J=8.4Hz, 1H), 7.17(s, 1H), 7.35–7.47



(m, 7H), 7.66–7.69(m, 2H)



IR(CHCl3)2938, 1604, 1584, 1518, 1478, 1370, 1331, 1241,



1176, 1150, 1010, 987, 937, 872, 846cm−1

















TABLE 223







I-1130
mp 142–144° C.



1H NMR(CDCl3)δ 1.76–1.77(d, J=0.9Hz, 3H), 1.79–1.80(d, J=



0.9Hz, 3H), 2.16(s, 2H), 2.60(s, 3H), 3.20(s, 3H), 3.57(s, 3H),



3.88(s, 3H), 4.62–4.65(d, J=6.6Hz, 2H), 5.55(m, 1H), 6.83–



6.87(m, 2H), 7.00(d, J=8.4Hz, 1H), 7.18(s, 1H), 7.35–7.38(m,



2H), 7.67–7.70(m, 2H)



IR(CHCl3)1604, 1582, 1517, 1478, 1416, 1370, 1332, 1240,



1176, 1150, 1093, 1008, 987, 936, 872cm−1


I-1131
mp 121–123° C.



1H NMR(DMSO-d6)δ 1.70(s, 3H), 1.71(s, 3H), 3.71–3.75(m,



4H), 3.75(s, 6H), 5.21–5.27(m, 2H), 5.54–5.59(m, 2H), 6.65–



6.71(m, 2H), 6.95(s, 2H), 7.19–7.29(m, 4H)



IR(KBr)3600–2800(br), 1627, 1536, 1497, 1470, 1454, 1375,



1341, 1257, 1208, 1125, 1053, 1035cm−1


I-1132
mp 169–170° C.



1H NMR(CDCl3)δ 1.77(d, J=0.6Hz, 3H), 1.81(d, J=0.9Hz, 3H),



2.26(s, 6H), 4.63(d, J=6.6Hz, 2H), 5.31(s, 1H), 5.34(s, 1H),



5.55(m, 1H), 6.80(dd, J=2.1, 8.1Hz, 1H), 6.89(d, J=2.1Hz, 1H),



6.92(d, J=8.1Hz, 1H), 6.98–7.13(m, 5H)



IR(KBr)3338, 1619, 1595, 1523, 1492, 1475, 1451, 1427, 1385,



1357, 1309, 1298, 1270, 1223, 1193, 1172, 1122, 1113, 999,



983, 871, 819, 785cm−1


I-1133
mp 135–136° C.



1H NMR(CDCl3)δ 1.14(t, J=6.9Hz, 3H), 2.42(s, 3H), 3.20(s,



3H), 3.73(q, J=6.9Hz, 2H), 3.77(s, 3H), 3.91(s, 3H), 5.22(s,



2H), 6.84(s, 1H), 6.91(dd, J=1.8, 8.4Hz, 1H), 6.98(d, J=8.4Hz,



1H), 6.98(d, J=1.8Hz, 1H), 7.28–7.47(m, 7H), 7.68–7.73



(m, 2H)



IR(KBr)1516, 1481, 1381, 1363, 1332, 1238, 1228, 1175, 1147,



1080, 1036, 865, 843, 800cm−1

















TABLE 224







I-1134
mp 154–155° C.



1H NMR(CDCl3)δ 1.15(t, J=7.2Hz, 3H), 1.75(d, J=0.9Hz, 3H),



1.79(d, J=0.9Hz, 3H), 2.54(s, 3H), 3.21(s, 3H), 3.72(q, J=7.2Hz,



2H), 3.78(s, 3H), 3.88(s, 3H), 4.63(d, J=6.9Hz, 2H), 5.54(m,



1H), 6.85(s, 1H), 6.95–6.98(m, 3H), 7.34–7.40(m, 2H), 7.68–



7.74(m, 2H)



IR(KBr)1519, 1481, 1467, 1365, 1335, 1245, 1231, 1184, 1157,



1081, 1038, 972, 889, 872, 840, 800cm−1


I-1135
mp 136–137° C.



1H NMR(CDCl3)δ 1.16(t, J=6.9Hz, 3H), 1.74(s, 3H), 1.78(s,



3H), 3.61(q, J=6.9Hz, 2H), 3.75(s, 3H), 3.88(s, 3H), 4.63(d, J=



6.9Hz, 2H), 5.03(s, 1H), 5.57(m, 1H), 5.99(s, 1H), 6.46(s, 1H),



6.89–6.94(m, 2H), 6.97(d, J=8.7Hz, 1H), 7.01(d, J=1.8Hz, 1H),



7.02(dd, J=1.8, 8.7Hz, 1H), 7.51–7.57(m, 2H)



IR(KBr)3433, 1613, 1522, 1489, 1464, 1443, 1402, 1383, 1364,



1270, 1235, 1214, 1174, 1140, 1113, 1072, 1036, 983, 825cm−1


I-1136
mp 155–157° C.



1H NMR(CDCl3)δ 2.05(t, J=2.7Hz, 1H), 2.76(dt, J=6.3, 2.7Hz,



2H), 2.77(s, 3H), 3.21(s, 3H), 3.28(s, 3H), 3.56(s, 3H), 3.78(s,



3H), 4.23(t, J=6.3Hz, 2H), 6.84(s, 1H), 7.09(d, J=8.4Hz, 1H),



7.36(dd, J=8.4, 2.1Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.41(d, J=2.1



Hz, 1H), 7.68(d, J=8.7Hz, 2H)



IR(Nujol)3285, 1608, 1519, 1176, 1151, 1119, 1079, 970, 870,



815, 797cm−1


I-1137
foam



1H NMR(CDCl3)δ 1.83(s, 3H), 2.58(t, J=6.6Hz, 2H), 2.74(s,



3H), 3.21(s, 3H), 3.22(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 4.22(t,



J=6.6Hz, 2H), 4.84(brs, 1H), 4.89(brs, 1H), 6.84(s, 1H), 7.10(d,



J=8.4Hz, 1H), 7.32~7.43(m, 4H), 7.68(d, J=8.7Hz, 2H),



IR(Nujol)1608, 1519, 1176, 1150, 1119, 1078, 968, 869,



816cm−1

















TABLE 225







I-1138
foam



1H NMR(CDCl3)δ 1.81(s, 3H), 2.55(t, J=6.6Hz, 2H), 3.45(s,



3H), 3.74(s, 3H), 4.20(t, J=6.6Hz, 2H), 4.85(brs, 1H), 4.89(brs,



1H), 6.45(s, 1H), 6.86~7.07(m, 5H), 7.53(d, J=8.7Hz, 2H),



IR(Nujol)3531, 3328, 1612, 1587, 1523, 1489, 1287, 1226,



1115, 1072, 1011cm−1


I-1139
foam



1H NMR(CDCl3)δ 2.07(t, J=2.7Hz, 1H), 2.72(dt, J=6.6, 2.7Hz,



2H), 3.45(s, 3H), 3.75(s, 3H), 4.21(t, J=6.6Hz, 2H), 6.45(s, 1H),



6.87~7.10(m, 5H), 7.53(d, J=8.7Hz, 2H)



IR(Nujol)3482, 3305, 1609, 1597, 1527, 1494, 1253, 1240,



1227, 1127, 1118, 1079, 1010cm−1


I-1140
m.p 194–197° C.



1H NMR(DMSO)δ 3.29(s, 3H), 3.64(s, 3H), 5.42(s, 2H), 6.38



(s, 1H), 6.61(dd, J=2.0, 8.2Hz, 1H), 6.74(d, J=2.0Hz, 1H), 6.84



(d, J=8.6Hz, 2H), 6.96(d, J=8.2Hz, 1H), 7.19(d, J=7.8Hz, 1H),



7.41(d, J=7.8Hz, 1H), 7.43(d, J=8.4Hz, 2H)



IR(KBr)3432, 1611, 1566, 1523, 1488, 1430, 1400, 1380, 1241,



1113, 1071, 814cm−1


I-1141
foam



1H NMR(CDCl3)δ 3.45(s, 3H), d 3.75(s, 3H), 3.92(s, 3H), 5.53



(s, 2H), 6.45(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.94(dd, J=2.1, 8.7



Hz, 1H), 7.01(d, J=8.7Hz, 1H), 7.10(d, J=2.1Hz, 1H), 7.28(d, J=



4.8Hz, 1H), 7.52(d, J=4.8Hz, 1H), 7.53(d, J=8.4Hz, 2H)



IR(KBr)3423, 1702, 1684, 1611, 1523, 1489, 1439, 1402, 1282,



1112, 1073, 1010, 814cm−1


I-1142
foam



1H NMR(CDCl3)δ 2.74(s, 3H), 3.21(s, 3H), 3.22(s, 3H), 3.55(s,



3H), d 3.78(s, 3H), 3.91(s, 3H), 5.19(s, 2H), 6.60(d, J=3.6Hz,



1H), 6.84(s, 1H), 7.15(d, J=8.4Hz, 1H), 7.17(d, J=3.6Hz, 1H),



7.36(dd, J=2.1, 8.4Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.41(d, J=2.1



Hz, 1H), 7.67(d, J=8.7Hz, 2H)



IR(KBr)1728, 1519, 1481, 1365, 1177, 1150, 1079, 969, 876,



797cm−1

















TABLE 226







I-1143
foam



1H NMR(CDCl3)δ 2.77(s, 3H), 3.21(s, 3H), 3.23(s, 3H), 3.56(s,



3H), d 3.78(s, 3H), 4.18(m, 2H), 4.78(m, 2H), 5.94(m, 2H),



6.84(s, 1H), 7.11(d, J=8.4Hz, 1H), 7.36(dd, J=2.1, 8.4Hz, 1H),



7.38(d, J=8.7Hz, 2H), 7.40(d, J=2.1Hz, 1H), 7.67(d, J=8.7Hz,



2H)



IR(KBr)1609, 1519, 1481, 1367, 1177, 1150, 1079, 970, 876,



797cm−1


I-1144
foam



1H NMR(CDCl3)δ 2.75(s, 3H), 3.21(s, 3H), 3.24(s, 3H), 3.55(s,



3H), d 3.78(s, 3H), 4.11(m, 2H), 4.64(m, 2H), 6.05(t, J=4.5Hz,



1H), 6.06(t, J=5.1Hz, 1H), 6.84(s, 1H), 7.07(d, J=8.7Hz, 1H),



7.35(dd, J=2.1, 8.7Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.40(d, J=



2.1Hz, 1H), 7.67(d, J=8.7Hz, 2H)



IR(KBr)1609, 1519, 1481, 1364, 1177, 1151, 1079, 969, 874,



797cm−1


I-1145
m.p 203–205° C.



1H NMR(CDCl3)δ 2.83(s, 3H), 3.22(s, 3H), 3.25(s, 3H), 3.55(s,



3H), d 3.79(s, 3H), 4.30(t, J=1.8Hz, 2H), 4.88(t, J=1.8Hz, 2H),



6.84(s, 1H), 7.20(d, J=8.7Hz, 1H), 7.37(dd, J=2.1, 8.7Hz, 1H),



7.39(d, J=8.7Hz, 2H), 7.42(d, J=2.1Hz, 1H), 7.67(d, J=8.7



Hz, 2H)



IR(KBr)3443, 1606, 1519, 1481, 1360, 1179, 1150, 1079, 877,



798cm−1


I-1146
m.p 173–174° C.



1H NMR(CD3OD)δ 3.38(s, 3H), 3.68(s, 3H), 4.23(t, J=1.8Hz,



2H), 4.83(t, J=1.8Hz, 2H), 6.43(s, 1H), 6.79(dd, J=2.1, 8.1Hz,



1H), 6.85(d, J=8.7Hz, 2H), 6.86(d, J=2.1Hz, 1H), 7.04(d, J=8.1



Hz, 1H), 7.45(d, J=8.7Hz, 2H)



IR(KBr)3399, 1612, 1586, 1523, 1487, 1401, 1217, 1114, 1067,



1013, 996, 828cm−1

















TABLE 227







I-1147
foam



1H NMR(CDCl3)δ 3.39(s, 3H), 3.45(s, 3H), 3.74(s, 3H), 4.17(t,



J=1.8Hz, 2H), 4.83(t, J=1.8Hz, 2H), 6.45(s, 1H), 6.91(d, J=8.7



Hz, 2H), 6.97(dd, J=2.1, 8.1Hz, 1H), 7.05(d, J=8.1Hz, 1H), 7.08



(d, J=2.1Hz, 1H), 7.52(d, J=8.7Hz, 2H)



IR(KBr)3411, 1612, 1589, 1523, 1489, 1404, 1224, 1114, 1071,



1010, 939, 816cm−1


I-1148
foam



1H NMR(CDCl3)δ 1.14(t, J=7.5Hz, 3H), 2.23(q, J=7.5Hz, 2H),



2.71(s, 3H), 3.21(s, 3H), 3.27(s, 3H), 3.60(s, 3H), 3.78(s, 3H),



4.80(s, 2H), 6.84(s, 1H), 7.20(d, J=9.0Hz, 1H), 7.37(dd, J=2.1,



9.0Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.42(d, J=2.1Hz, 1H), 7..68



(d, J=8.7Hz, 2H)



IR(KBr)2232, 1609, 1519, 1481, 1365, 1177, 1151, 1079, 970,



876, 797cm−1


I-1149
mp >280° C. (decomp.)



1H NMR(DMSO-d6)δ 3.30(s, 3H), 3.64(s, 3H), 4.85(s, 2H),



6.39(s, 1H), 6.69(dd, J=8.4, 2.1Hz, 1H), 6.79(d, J=2.1Hz, 1H),



6.84(d, J=8.7Hz, 2H), 6.94(d, J=8.4Hz, 1H), 7.44(d, J=8.7Hz,



2H), 8.54(s, 1H)



IR(Nujol)3166, 1707, 1671, 1611, 1586, 1523, 1489, 1288,



1259, 1211, 1115, 1075, 1012, 814cm−1


I-1150
foam



1H NMR(CDCl3)δ 1.91(s, 3H), 3.45(s, 3H), 3.75(s, 3H), 4.89(s,



2H), 5.29(brs, 1H), 5.36(brs, 1H), 6.45(s, 1H), 6.92(d, J=8.7



Hz, 2H), 6.97(dd, J=8.4, 2.1Hz, 1H), 7.07(d, J=8.4Hz, 1H), 7.08



(d, J=2.1Hz, 1H), 7.54(d, J=8.7Hz, 2H)



IR(KBr)3432, 1612, 1588, 1523, 1489, 1288, 1224, 1192, 1113,



1070, 1010, 938, 825, 813cm−1


I-1151
foam



1H NMR(CDCl3)δ 3.45(s, 3H), 3.75(s, 3H), 4.98(d, J=1.8Hz,



2H), 5.92(dt, J=7.5, 1.8Hz, 1H), 6.45(s, 1H), 6.46(d, J=7.5Hz,



1H), 6.92(d, J=8.7Hz, 2H), 6.98(dd, J=8.4, 2.1Hz, 1H), 7.09(d,



J=2.1Hz, 1H), 7.11(d, J=8.4Hz, 1H), 7.53(d, J=8.7Hz, 2H)



IR(KBr)3410, 1612, 1589, 1523, 1489, 1403, 1224, 1112, 1070,



1011, 938, 826cm−1

















TABLE 228







I-1152
foam



1H NMR(CDCl3)δ 3.45(s, 3H), 3.75(s, 3H), 4.89(d, J=2.1Hz,



2H), 5.97(dt, J=13.8, 2.1Hz, 1H), 6.45(s, 1H), 6.61(d, J=13.8



Hz, 1H), 6.92(d, J=8.7Hz, 2H), 6.97(dd, J=8.4, 2.1Hz, 1H), 7.04



(d, J=8.4Hz, 1H), 7.09(d, J=2.1Hz, 1H), 7.54(d, J=8.7Hz, 2H)



IR(KBr)3427, 1612, 1588, 1523, 1489, 1403, 1226, 1192, 1175,



1113, 1070, 1011, 938, 918, 826cm−1


I-1153
mp 188–189° C.



1H NMR(CDCl3)δ 2.84(s, 3H), 3.33(s, 3H), 3.74(s, 3H), 3.98(s,



3H), 4.18(s, 3H), 5.38(s, 2H), 7.05(s, 1H), 7.36–7.64(m, 10H),



8.61(d, J=8.7Hz, 1H), 8.82(brs, 1H)



IR(KBr)3381, 2942, 1724, 1538, 1481, 1369, 1296, 1177, 1163,



1082, 963, 821cm−1


I-1154
mp 78–80° C.



1H NMR(CDCl3)δ 2.17(s, 3H), 2.67(s, 3H), 3.13(s, 3H), 3.57(s,



3H), 3.79(s, 3H), 5.19(s, 2H), 6.83(s, 1H), 7.15(d, J=8.6Hz,



1H), 7.31–7.45(m, 7H), 7.62(d, J=8.2Hz, 1H), 7.79(s, 1H), 8.44



(d, J=8.6Hz, 1H), 8.51(brs, 1H)



IR(KBr)3398, 2939, 1739, 1529, 1477, 1368, 1287, 1240, 1177,



1119, 1078, 957, 815, 796, 522cm−1


I-1155
mp 74–75° C.



1H NMR(CDCl3)δ 1.68(s, 3H), 1.76(s, 6H), 1.81(s, 3H), 2.69(s,



3H), 3.24(s, 3H), 3.52(s, 3H), 3.80(s, 3H), 3.88(s, 3H), 3.88–



4.02(m, 2H), 4.64(d, J=7.2Hz, 2H), 5.25(t, J=7.8Hz, 1H), 5.50



(t, J=5.7Hz, 1H), 6.88(s, 1H), 7.08–7.38(m, 6H)



IR(KBr)3412, 2939, 1697, 1519, 1483, 1366, 1268, 1207, 1178,



1080, 964, 808, 523cm−1


I-1156
mp 72–74° C.



1H NMR(CDCl3)δ 1.95(s, 3H), 1.99(s, 3H), 2.87(s, 3H), 3.42(s,



3H), 3.74(s, 3H), 3.97(s, 3H), 4.16(s, 3H), 4.82(d, J=6.6Hz,



2H), 5.68(t, J=5.7Hz, 1H), 7.04(s, 1H), 7.27(d, J=8.1Hz, 1H),



7.39–7.56(m, 4H), 8.60(d, J=8.4Hz, 1H), 8.81(brs, 1H)



IR(KBr)3407, 2940, 1731, 1601, 1538, 1481, 1366, 1294, 1178,



1165, 1079, 805, 562cm−1

















TABLE 229







I-1157
mp 68–69° C.



1H NMR(CDCl3)δ 1.70(s, 3H), 1.77(s, 3H), 1.81(s, 3H), 2.70(s,



3H), 3.25(s, 3H), 3.55(s, 3H), 3.81(s, 3H), 4.64(d, J=6.6Hz,



2H), 5.27(t, J=7.5Hz, 1H), 5.50(t, J=6.9Hz, 1H), 6.86(s, 1H),



7.10(d, J=8.4Hz, 1H), 7.25–7.40(m, 3H), 7.57(d, J=8.1Hz, 1H),



7.76(s, 1H)



IR(KBr)3422, 2939, 1701, 1519, 1480, 1368, 1203, 1177, 1078,



957, 801, 522cm−1


I-1158
mp 64–66° C.



1H NMR(CDCl3)δ 3.47(s, 3H), 3.74(s, 3H), 5.19(s, 2H), 5.86



(brs, 1H), 6.44(s, 1H), 7.08–7.69(m, 11H), 8.06(brs, 1H)



IR(KBr)3399, 2938, 1726, 1624, 1604, 15263, 1487, 1403,



1302, 1208, 1178, 1068, 695, 520cm−1


I-119
mp 68–70° C.



1H NMR(CDCl3)δ 2.57(s, 3H), 3.57(s, 3H), 3.76(s, 3H), 5.21(s,



2H), 6.84(s, 1H), 7.11–7.73(m, 11H), 8.29(brs, 1H)



IR(KBr)3422, 2939, 1728, 1605, 1523, 1482, 1397, 1367, 1233,



1209, 1178, 1078, 795, 725, 542cm−1


I-1160
mp 72–73° C.



1H NMR(CDCl3)δ 1.75(s, 6H), 1.78(s, 3H), 1.82(s, 3H), 3.48(s,



3H), 3.75(s, 3H), 3.76(d, J=7.2Hz, 2H), 3.89(s, 3H), 4.38(brs,



1H), 4.61(d, J=6.9Hz, 2H), 5.41(t, J=6.3Hz, 1H), 5.53(t, J=



6.9Hz, 1H), 5.68(brs, 1H), 5.94(brs, 1H), 6.49(s, 3H), 6.69(d, J=



8.4Hz, 1H), 6.95(s, 1H), 7.06(s, 1H), 7.13–7.15(m, 2H), 7.26



(s, 1H)



IR(KBr)3423, 2932, 1608, 1528, 1490, 1459, 1250, 1113, 1071,



805, 757cm−1


I-1161
mp 68–69° C.



1H NMR(CDCl3)δ 1.76(s, 3H), 1.81(s, 3H), 3.48(s, 3H), 3.75(s,



3H), 3.91(s, 3H), 4.61(d, J=7.2Hz, 2H), 5.53(t, J=6.0Hz, 1H),



5.91(brs, 2H), 6.47(s, 1H), 6.83(d, J=8.1Hz, 2H), 6.95(s, 1H),



7.06–7.09(m, 2H), 7.16(s, 1H), 7.26(s, 1H)



IR(KBr)3406, 2933, 1524, 1490, 1397, 1270, 1241, 1116, 1075,



1069, 811, 773cm−1

















TABLE 230







I-1162
mp 81–83° C.



1HNMR(CDCl3)δ 1.76(s, 6H), 1.79(s, 3H), 1.81(s, 3H),



3.50(s, 3H), 3.75(s, 3H), 3.80(d, J=6.6Hz, 2H), 4.36(brs, 1H),



4.61(d, J=6.9Hz, 2H), 5.39(t, J=6.3Hz, 1H), 5.53(t, J=6.6Hz,



1H), 5.68(brs, 1H), 5.90(brs, 1H), 6.43(s, 1H), 6.73(d, J=8.4Hz,



1H), 6.95(s, 1H), 7.05(s, 1H), 7.26(d, J=0.9Hz, 1H), 7.47(dd,



J=2.1, 8.4Hz, 1H), 7.59(d, J=2.1Hz, 1H)



IR(KBr)3484, 2931, 1607, 1525, 1488, 1310, 1243, 1114, 1070,



1009, 808cm−1


I-1163
mp 87–89° C.



1HNMR(CDCl3)δ 2.81(s, 3H), 3.60(s, 3H), 3.77(s, 3H),



3.98(d, J=6.3Hz, 2H), 4.80(d, J=6.3Hz, 2H), 6.07(t, J=6.0Hz,



1H), 6.25(t, J=6.3Hz, 1H), 6.46–6.53(m, 2H), 6.86(s, 1H),



7.05–7.38(m, 4H)



IR(KBr)3411, 2937, 1628, 1527, 1482, 1364, 1233, 1176, 1077,



960, 879, 792, 524cm−1


I-1164
amorphous



1HNMR(CDCl3)δ 2.68(s, 3H), 3.13(s, 3H), 3.43(s, 3H),



3.54(s, 3H), 3.80(s, 3H), 5.19(s, 2H), 6.87(s, 1H), 7.16(d,



J=8.7Hz, 1H), 7.32–7.49(m, 9H), 7.69(d, J=8.4Hz, 2H)



IR(KBr)1698, 1522, 1482, 1367, 1080, 1014, 947, 815, 795cm−1


I-1165
foam



1HNMR(CDCl3)δ 1.47(s, 3H), 1.72(s, 3H), 1.77(s, 3H),



1.81(s, 3H), 2.71(s, 3H), 3.24(s, 3H), 3.51(s, 3H), 3.80(s, 3H),



4.37(d, J=7.8Hz, 2H), 4.64(d, J=6.6Hz, 2H), 5.29(t, J=7.8Hz,



1H), 5.50(t, J=6.6Hz, 1H), 6.88(s, 1H), 7.09(d, J=8.4Hz, 1H),



7.27(d, J=8.7Hz, 2H), 7.35(dd, J=8.4, 2.3Hz, 1H), 7.39(d,



J=2.3Hz, 1H), 7.66(d, J=8.7Hz, 2H)



IR(KBr)1696, 1521, 1482, 1366, 1177, 1080, 972, 946, 814,



795cm−1


I-1166
mp 135–136° C.



1HNMR(CDCl3)δ 1.77(s, 3H), 1.81(s, 3H), 2.71(s, 3H),



3.24(s, 3H), 3.54(s, 3H), 3.80(s, 3H), 4.64(d, J=6.7Hz, 2H),



5.50(t, J=6.7Hz, 1H), 6.87(s, 1H), 7.10(d, J=8.4Hz, 1H),



7.34(d, J=8.1Hz, 2H), 7.35(dd, J=8.4, 2.2Hz, 1H), 7.39(d,



J=2.2Hz, 1H), 7.69(d, J=8.1Hz, 2H)



IR(KBr)1702, 1522, 1481, 1362, 1275, 1150, 1081, 1014, 978,



817, 793cm−1

















TABLE 231







I-1167
mp 169–171° C.



1HNMR(DMSO-d6)δ 1.71(s, 3H), 1.72(s, 6H), 1.76(s, 3H),



3.31(s, 3H), 3.63(s, 3H), 3.64(m, 2H), 4.54(d, J=6.8Hz, 2H),



5.29(t, J=7.5Hz, 1H), 5.49(t, J=6.8Hz, 1H), 5.75(t, J=8.1Hz,



1H), 6.37(s, 1H), 6.63(d, J=8.4Hz, 2H), 6.64(dd, J=8.1, 2.0Hz,



1H), 6.73(d, J=2.0Hz, 1H), 6.88(d, J=8.4Hz, 2H), 7.37(d,



J=8.4Hz, 2H), 8.41(s, 1H), 8.70(s, 1H)



IR(KBr)3473, 3276, 1608, 1523, 1491, 1310, 1252, 1190, 1112,



1072, 934, 824, 776cm−1


I-1168
mp 159–160° C.



1HNMR(DMSO-d6)δ 1.72(s, 3H), 1.76(s, 3H), 3.31(s, 3H),



3.64(s, 3H), 4.54(d, J=6.8Hz, 2H), 5.49(t, J=6.8Hz, 1H),



5.76(brs, 1H), 6.37(s, 1H), 6.61(d, J=8.4Hz, 2H), 6.64(dd,



J=8.1, 2.0Hz, 1H), 6.73(d, J=2.0Hz, 1H), 6.88(d, J=8.1Hz,



1H), 7.39(d, J=8.4Hz, 2H), 7.37(d, J=8.4Hz, 2H), 8.42(brs,



1H), 8.70(brs, 1H)



IR(KBr)3458, 3332, 1609, 1524, 1492, 1411, 1393, 1295, 1234,



1107, 1071, 1012, 994, 781cm−1


I-1169
mp 183–184° C.



1HNMR(CDCl3)δ 1.76(d, J=0.6Hz, 3H), 1.82(s, 3H),



3.13(s, 3H), 3.48(s, 3H), 3.76(s, 3H), 4.63(d, J=6.9Hz, 2H),



5.53(m, 1H), 5.72(s, 1H), 5.83(s, 1H), 6.46(s, 1H), 6.93(dd,



J=1.8, 8.4Hz, 1H), 6.98(d, J=8.4Hz, 1H), 7.04(d, J=1.8Hz,



1H), 7.82–7.89(m, 2H), 8.00–8.06(m, 2H)



IR(KBr)3445, 1593, 1499, 1482, 1461, 1387, 1311, 1278, 1245,



1189, 1146, 1111, 1086, 1068, 1010, 997, 942, 766cm−1


I-1170
mp 178–179° C.



1HNMR(CDCl3)δ 1.76(s, 3H), 1.82(s, 3H), 2.80(s, 3H),



3.47(s, 3H), 3.76(s, 3H), 4.62(d, J=7.2Hz, 2H), 5.53(m, 1H),



5.72(s, 1H), 5.86(s, 1H), 6.47(s, 1H), 6.94(dd, J=1.8, 8.1Hz,



1H), 6.98(d, J=8.1Hz, 1H), 7.05(d, J=1.8Hz, 1H), 7.72–7.77



(m, 2H), 7.79–7.85(m, 2H)



IR(KBr)3420, 1587, 1527, 1482, 1449, 1430, 1416, 1390, 1357,



1290, 1240, 1214, 1198, 1135, 1115, 1073, 1019, 998, 975, 962,



937, 831cm−1

















TABLE 232







I-1171
mp 136–139° C.



1HNMR(CDCl3)δ 1.73(s, 3H), 1.77(s, 3H), 2.99(s, 6H),



3.71(d, J=6.6Hz, 2H), 3.76(s, 3H), 3.78(s, 3H), 5.32–5.37



(m, 1H), 6.36–6.46(m, 2H), 6.79–6.84(m, 2H), 6.89(s, 1H),



6.95(s, 1H), 7.18–7.24(m, 1H), 7.47–7.52(m, 2H)



IR(KBr)3600–2800(br), 1626, 1609, 1531, 1493, 1460, 1444,



1388, 1345, 1232, 1207, 1173, 1124, 1050, 1028cm−1


I-1172
mp 113–114° C.



1HNMR(CDCl3)δ 3.00(s, 6H), 3.77(s, 3H), 3.78(s, 3H),



6.78–6.84(m, 2H), 6.88(s, 1H), 6.98(s, 1H), 7.31(dd, J=2.1,



8.4Hz, 1H), 7.43–7.53(m, 3H), 7.58(dd, J=1.8, 11.1Hz, 1H)



IR(KBr)3600–2800(br), 1711, 1609, 1533, 1493, 1464, 1390,



1212, 1181, 1162, 1052, 1027cm−1


I-1173
mp 141–143° C.



1HNMR(CDCl3)δ 1.75(d, J=0.9Hz, 3H), 1.78(d, J=0.9Hz,



3H), 2.99(s, 6H), 3.50(s, 3H), 3.74(s, 3H), 3.78(d, J=6.6Hz,



2H), 3.93(br, 1H), 5.35–5.40(m, 1H), 5.86(s, 1H), 6.44(s, 1H),



6.74–6.86(m, 3H), 7.30–7.38(m, 4H)



IR(KBr)3600–2800(br), 1625, 1611, 1530, 1491, 1458, 1444,



1400, 1348, 1333, 1250, 1217, 1103, 1075cm−1


I-1174
mp 226–228° C.



1HNMR(CDCl3)δ 3.93(s, 3H), 4.95(s, 1H), 5.21(s, 2H),



6.90–6.94(m, 2H), 6.96(s, 1H), 6.97(s, 1H), 7.03(d, J=0.9Hz,



1H), 7.30–7.49(m, 1H)



IR(KBr)3600–2800(br), 1608, 1589, 1520, 1471, 1446, 1384,



1358, 1270, 1250, 1238, 1210, 1172, 1141, 1093, 1031,



997cm−1


I-1175
mp 143–145° C.



1HNMR(CDCl3)δ 3.21(s, 3H), 3.93(s, 3H), 5.22(s, 2H),



6.97(s, 2H), 7.03(s, 1H), 7.30–7.55(m, 11H)



IR(KBr)3600–2800(br), 1602, 1517, 1468, 1368, 1348, 1248,



1210, 1176, 1151, 1095, 1038, 989cm−1

















TABLE 233







I-1176
mp 98–100° C.



1HNMR(CDCl3)δ 1.76(s, 3H), 1.79(s, 3H), 3.21(s, 3H),



3.91(s, 3H), 4.65(d, J=6.9Hz, 2H), 5.53–5.58(m, 1H), 6.94–7.03



(m, 3H), 7.23–7.41(m, 2H), 7.45(s, 1H), 7.49(s, 1H),



7.51–7.56(m, 1H)



IR(KBr)3600–2800(br), 1604, 1583, 1519, 1470, 1449, 1365,



1250, 1202, 1177, 1151, 1095, 1041, 972cm−1


I-1177
mp 118–120° C.



1HNMR(CDCl3)δ 1.76(s, 3H), 1.79(s, 3H), 3.91(s, 3H),



4.64(d, J=6.9Hz, 2H), 5.53–5.58(m, 1H), 6.88–7.02(m, 5H),



7.23–7.37(m, 2H), 7.44(s, 1H), 7.46(s, 1H)



IR(KBr)3600–2800(br), 1626, 1609, 1526, 1490, 1429, 1253,



1187cm−1


I-1178
mp 161–164° C.



1HNMR(CDCl3)δ 3.00(s, 3H), 3.79(s, 3H), 3.80(s, 3H),



6.78–6.83(m, 2H), 6.90(s, 1H), 6.97(s, 1H), 7.47–7.52(m, 2H),



7.71(d, J=1.8Hz, 1H), 8.37(d, J=8.7Hz, 1H), 8.46(brs, 1H)



IR(KBr)3600–2800(br), 1716, 1613, 1532, 1505, 1487, 1463,



1384, 1357, 1280, 1195, 1172, 1059, 1033cm−1


I-1179
mp 135–137° C.



1HNMR(CDCl3)δ 1.74(s, 3H), 1.78(s, 3H), 3.00(s, 6H),



3.78(s, 3H), 3.79(s, 3H), 4.29(d, J=6.6Hz, 1H), 5.35–5.40



(m, 1H), 6.71(d, J=8.4Hz, 1H), 6.80–6.83(m, 2H), 6.90(s, 1H),



6.94(s, 1H), 7.38–7.42(m, 1H), 7.48–7.56(m, 3H)



IR(KBr)3600–2800(br), 1612, 1532, 1495, 1460, 1444, 1385,



1365, 1273, 1257, 1203, 1059, 1039, 1029cm−1


I-1180
1HNMR(CDCl3)δ 1.57(d, J=6.3Hz, 3H), 2.26(s, 3H),



2.28(s, 3H), 5.18(s, 2H), 5.22(q, J=6.3Hz, 1H), 7.02(d,



J=8.4Hz, 1H), 7.12(s, 1H), 7.15(s, 1H), 7.23(d.d, J=8.4&



2.1Hz, 1H), 7.30–7.51(m, 10H)



IR(KBr)3557, 1605, 1486, 1370, 1235, 1177, 1149, 1078,



1017cm−1


I-1181
1HNMR(CDCl3)δ 1.66(s, 6H), 2.27(s, 3H), 2.28(s, 3H),



3.20(s, 3H), 4.22(s, 1H), 5.22(s, 2H), 7.06(d, J=8.4Hz, 1H),



7.12(s, 1H), 7.14(s, 1H), 7.23(d.d, J=8.4&2.1Hz, 1H),



7.30–7.51(m, 10H)



IR(KBr)3544, 3441, 1604, 1512, 1485, 1367, 1222, 1173,



1149cm−1

















TABLE 234







I-1182
1HNMR(CDCl3)δ 1.28(t, J=7.2Hz, 3H), 2.26(s, 3H),



2.28(s, 3H), 2.70(q, J=7.2Hz, 2H), 3.20(s, 3H), 4.73(s, 1H),



6.82(d, J=8.4Hz, 1H), 7.03–7.11(m, 2H), 7.14(s, 1H),



7.15(s, 1H), 7.29–7.46(m, 4H)



IR(KBr)3510, 1605, 1515, 1488, 1369, 1263, 1177, 1147,



1117cm−1


I-1183
1HNMR(CDCl3)δ 1.29(d, J=6.9Hz, 6H), 2.27(s, 3H),



2.28(s, 3H), 3.20(s, 3H), 3.27(qintet, J=6.9Hz, 1H),



4.76(s, 1H), 6.81(d, J=7.8Hz, 1H), 7.07(d.d, J=7.8&2.1Hz,



1H), 7.11(s, 1H), 7.15(s, 1H), 7.20(d, J=2.1Hz, 1H), 7.34(d,



J=8.7Hz, 2H), 7.42(d, J=8.7Hz, 2H),



IR(KBr)3511, 1606, 1484, 1356, 1174, 1151cm−1


I-1184
1HNMR(CDCl3)δ 1.23(t, J=8.1Hz, 3H), 1.77(s, 3H),



1.82(s, 3H), 2.26(s, 3H), 2.29(s, 3H), 2.70(q, J=8.1Hz, 2H),



3.20(s, 3H), 4.58(d, J=6.6Hz, 2H), 5.48–5.57(m, 1H),



6.90(d, J=7.8Hz, 1H), 7.08–7.13(m, 2H), 7.16(s, 2H),



7.23–7.47(m, 4H)



IR(KBr)1605, 1485, 1369, 1352, 1236, 1201, 1174, 1150, 1133,



1008cm−1


I-1185
1HNMR(CDCl3)δ 1.23(t, J=7.5Hz, 3H), 1.76(s, 3H),



1.81(s, 3H), 2.27(s, 3H), 2.29(s, 3H), 2.70(q, J=7.5Hz, 2H),



4.57(d, J=6.6Hz, 2H), 4.79(brs, 1H), 5.49–5.58(m, 1H),



6.83–6.92(m, 3H), 7.08–7.19(m, 4H), 7.27(d, J=8.4Hz, 2H)



IR(KBr)3529, 1608, 1519, 1487, 1241, 1136, 1024cm−1


I-1186
1HNMR(CDCl3)δ 1.23(d, J=1.8Hz, 6H), 1.76(s, 3H),



1.82(s, 3H), 2.27(s, 3H), 2.29(s, 3H), 3.20(s, 3H), 3.40(quintet,



J=1.8Hz, 1H), 4.58(d, J=6.6Hz, 2H), 5.48–5.59(m, 1H),



6.90(d, J=7.8Hz, 1H), 7.10–7.44(m, 8H)



IR(KBr)1602, 1468, 1369, 1232, 1174, 1151cm−1


I-1187
1HNMR(CDCl3)δ 1.24(d, J=6.9Hz, 6H), 1.76(s, 3H),



1.81(s, 3H), 2.27(s, 3H), 2.29(s, 3H), 3.40(quintet, J=6.9Hz,



1H), 4.58(d, J=6.6Hz, 2H), 4.79(broad, s., 1H), 5.50–5.57(m,



1H), 6.84–6.93(m, 3H), 7.09–7.16(m, 3H), 7.00–7.28(m, 3H)



IR(KBr)3265, 1607, 1519, 1486, 1448, 1383, 1232, 1170cm−1

















TABLE 235







I-1188
1HNMR(CDCl3)δ 1.31(d, J=6.9Hz, 6H), 1.44(s, 3H),



1.67(s, 3H), 2.97(quintet, J=6.9Hz, 1H), 3.78(s, 3H),



3.80(s, 3H), 3.92(s, 3H), 4.20–4.30(broad, 1H), 5.17–5.30



(m, 1H), 6.96(s, 1H), 6.99(s, 1H), 7.07–7.35(m, 5H), 7.52(d,



J=8.1Hz, 2H)



IR(KBr)3422, 1601, 1529, 1492, 1462, 1378, 1341, 1257, 1203,



1138, 1028cm−1


I-1189
1HNMR(CDCl3)δ 2.67(s, 3H), 3.13(s, 3H), 3.57(s, 3H),



3.79(s, 3H), 5.19(s, 2H), 6.84(s, 1H), 7.15(d, J=9.0Hz, 1H),



7.31–7.50(m, 8H), 7.55(d.d, J=12.0&1.8Hz, 1H), 8.34–8.41



(m, 1H)



IR(KBr)3428, 1740, 1601, 1535, 1482, 1366, 1292, 1238, 1177,



1164, 1112, 1079, 1013cm−1


I-1190
1HNMR(CDCl3)δ 1.48(s, 3H), 1.70(s, 3H), 1.77(s, 3H),



1.81(s, 3H), 2.70(s, 3H), 3.24(s, 3H), 3.55(s, 3H), 3.81(s, 3H),



4.09–4.20(m, 1H), 4.53–4.68(m, 3H), 5.18–5.30(m, 1H),



5.43–5.54(m, 1H), 6.86(s, 1H), 7.06–7.51(m, 6H)



IR(KBr)1702, 1521, 1482, 1367, 1204, 1177, 1115, 1080cm−1


I-1191
1HNMR(CDCl3)δ 1.75(s, 6H), 1.78(s, 3H), 1.82(s, 3H),



3.49(s, 3H), 3.74(s, 3H), 3.79(d, J=6.3Hz, 2H), 4.61(d, J=6.6Hz,



2H), 5.32–5.43(m, 1H), 5.49–5.57(m, 1H), 5.68(s, 1H),



5.90(s, 1H), 6.44(s, 1H), 6.74–6.85(m, 1H), 6.95(s, 2H),



7.05(s, 1H), 7.29–7.38(m, 2H)



IR(KBr)3527, 1624, 1530, 1491, 1248, 1221, 1197, 1125, 1105,



1072cm−1


I-1192
1HNMR(CDCl3)δ 1.75(s, 3H), 1.78(s, 3H), 3.49(s, 3H),



3.73(s, 3H), 3.78(d, J=6.9Hz, 2H), 5.32–5.43(m, 1H),



6.44(s, 1H), 6.73–6.97(m, 4H), 7.25–7.37(m, 2H)



IR(KBr)3551, 3437, 3310, 1607, 1529, 1491, 1463, 1402, 1362,



1269, 1255, 1184, 1099, 1070, 1013cm−1


I-1193
1HNMR(CDCl3)δ 2.28(s, 3H), 2.30(s, 3H), 3.00(s, 6H),



5.16(s, 2H), 5.69(s, 1H), 6.80(d, J=8.7Hz, 2H), 6.84(d.d,



J=8.1&2.1Hz, 1H), 6.98(.d, J=8.1Hz, 1H), 6.99(d, J=2.1Hz,



1H), 7.12(s, 1H), 7.13(s, 1H), 7.27(d, J=8.7Hz, 2H), 7.34–7.50



(m, 5H)



IR(KBr)1605, 1525, 1490, 1417, 1242, 1199, 1127, 1006cm−1

















TABLE 236







I-1194
mp 174–175° C.



1HNMR(CDCl3)δ 3.48(s, 3H), 3.78(s, 3H), 4.41(s, 4H),



5.17(s, 2H), 5.71(s, 1H), 5.88(s, 1H), 6.48(s, 1H), 6.94–7.50



(m, 18H), 7.86(ABq, J=8.4Hz, 4H)



IR(KBr)3463, 3409, 1588, 1519, 1482, 15455, 1417, 1385,



1321, 1285, 1247, 1154, 1112, 1096, 1067, 1015cm−1


I-1195
mp 165–167° C.



1HNMR(CDCl3)δ 2.68(s, 3H), 3.14(s, 3H), 3.56(s, 3H),



3.81(s, 3H), 4.40(s, 4H), 5.20(s, 2H), 6.86(s, 1H), 7.09–7.50



(m, 18H), 7.79(ABq, J=8.1Hz, 4H)



IR(KBr)3434, 2938, 1606, 1596, 1518, 1478, 1455, 1368, 1335,



1293, 1268, 1239, 1174, 1157, 1118, 1079cm−1


I-1196
mp 176–178° C.



1HNMR(CDCl3)δ 1.58(s, 3H), 1.66(s, 3H), 1.77(s, 3H),



1.81(s, 3H), 2.71(s, 3H), 3.24(s, 3H), 3.55(s, 3H), 3.64(m, 2H),



3.80(s, 3H), 4.28(t, J=6.0Hz, 1H), 4.64(d, J=6.9Hz, 2H),



5.10(m, 1H), 5.49(m, 1H), 6.86(s, 1H), 7.10(d, J=8.4Hz, 1H),



7.35(dd, J=2.1, 8.4Hz, 1H), 7.39(d, J=2.1Hz, 1H), 7.87(ABq,



J=8.7Hz, 4H)



IR(KBr)3434, 3321, 2939, 1517, 1477, 1366, 1325, 1292, 1269,



1240, 1176, 1156, 1120, 1077cm−1


I-1197
mp 180–181° C.



1HNMR(DMSO)δ 1.74(s, 3H), 1.77(s, 3H), 2.87(s, 3H),



3.36(s, 3H), 3.51(s, 3H), 3.79(s, 3H), 4.68(d, J=6.6Hz, 2H),



5.48(m, 1H), 7.10(s, 1H), 7.28–7.30(m, 3H), 7.45(bs, 2H),



7.87(ABq, J=8.7Hz, 4H)



IR(KBr)3340, 3238, 2939, 1598, 1518, 1481, 1362, 1333, 1291,



1270, 1239, 1172, 1161, 1120, 1076, 1007cm−1


I-1198
oil



1HNMR(CDCl3)δ 1.45(s, 3H), 1.66(s, 3H), 1.87(s, 3H),



2.24(s, 3H), 2.27(s, 3H), 2.30(s, 3H), 3.84(s, 3H), 3.92(s, 3H),



3.95–4.03(m, 1H), 4.50–4.58(m, 1H), 5.22–5.29(m, 1H),



6.87–6.99(m, 4H), 7.09–7.17(m, 3H), 7.80(s, 1H), 8.34–8.42



(m, 1H)



IR(CHCl3)3673, 3021, 1685, 1639, 1525, 1495, 1406, 1237,



1128, 1037cm−1

















TABLE 237







I-1199
mp 177–179° C.



1HNMR(CDCl3)δ 1.45(s, 6H), 1.66(s, 6H), 1.87(s, 6H),



2.29(s, 6H), 3.85(s, 6H), 3.95–4.04(m, 2H), 4.50–4.59(m, 2H),



5.23–5.29(m, 2H), 6.90–6.95(m, 4H), 7.10–7.15(m, 2H),



7.19(s, 2H)



IR(KBr)2929, 1661, 1492, 1405, 1288, 1214, 1030, 869,



829cm−1


I-1200
mp 224–226° C.



1HNMR(CDCl3)δ 2.88(s, 3H), 3.22(s, 3H), 3.54(s, 3H),



3.78(s, 3H), 6.43(s, 1H), 6.85(s, 1H), 7.01(d, J=8.4Hz, 1H),



7.20(dd, J=2.1, 8.4Hz, 1H), 7.35–7.42(m, 2H), 7.65–7.72



(m, 2H), 7.96(d, J=2.1Hz, 1H), 8.96(s, 1H)



IR(KBr)3441, 3370, 3024, 2938, 1729, 1508, 1481, 1365, 1177,



1148, 1085, 884, 798, 524cm−1


I-1201
powder



1HNMR(CDCl3)δ 1.77(s, 3H), 1.82(s, 3H), 2.80(s, 3H),



3.21(s, 3H), 3.56(s, 3H), 3.79(s, 3H), 4.67(d, J=6.6Hz, 2H),



5.46–5.51(m, 1H), 6.84(s, 1H), 7.05(d, J=8.1Hz, 1H), 7.22–7.26



(m, 1H), 7.36–7.41(m, 2H), 7.67–7.71(m, 2H), 8.35



(d, J=1.8Hz, 1H), 9.24(s, 1H)



IR(KBr)3385, 2937, 1718, 1532, 1479, 1362, 1175, 1152, 1078,



973, 876, 797, 526cm−1


I-1202
mp 260–262° C.



1HNMR(DMSO)δ 2.27(s, 6H), 3.87(s, 6H), 7.00(dd, J=1.8,



8.1Hz, 2H), 7.10(d, J=1.8Hz, 2H), 7.21(s, 2H), 7.48(d, J=8.1Hz,



2H), 10.73(s, 2H)



IR(KBr)3392, 3008, 1719, 1600, 1542, 1413, 1297, 1158, 1032,



905, 627cm−1


I-1203
mp 143–144° C.



1HNMR(CDCl3)δ 1.76(s, 3H), 1.82(s, 3H), 3.61(s, 3H),



3.67(s, 3H), 3.73(s, 3H), 3.87(s, 3H), 4.62(d, J=6.9Hz, 2H),



5.50–5.58(m, 1H), 5.66(s, 1H), 6.86–7.02(m, 5H), 7.54(d,



J=9Hz, 2H)



IR(KBr)3494, 2935, 1673, 1609, 1584, 1519, 1479, 1456, 1389,



1284, 1249, 1178, 1109, 1081, 1016, 829, 798cm−1

















TABLE 238







I-124
mp 90–91° C.



1HNMR(CDCl3)δ 1.72(s, 3H), 1.79(s, 3H), 2.26(s, 6H),



4.69(d, J=7.2Hz, 2H), 4.9–5.0(brs, 1H), 5.57(t, J=7.2Hz, 1H),



6.85–7.0(m, 4H), 7.10(d, J=8.7Hz, 2H), 7.23(d, J=8.7Hz, 2H)



IR(KBr)3253, 3013, 2979, 2928, 1676, 1584, 1521, 1492, 1232,



1034, 950, 848, 825cm−1


I-1205
mp 131–132° C.



1HNMR(CDCl3)δ 1.73(s, 3H), 1.79(s, 3H), 3.43(s, 3H),



3.76(s, 3H), 4.68(d, J=6.9Hz, 2H), 4.9–5.1(brs, 1H), 5.58(t,



J=7.2Hz, 1H), 6.09(brs, 1H), 6.44(s, 1H), 6.92(d, J=8.4Hz, 2H),



7.0–7.1(m, 2H), 7.52(d, J=8.4Hz, 2H)



IR(KBr)3428, 2951, 2932, 1671, 1611, 1523, 1491, 1402, 1233,



1111, 1077, 1027, 969, 833cm−1


I-1206
mp 191–192° C.



1HNMR(CDCl3)δ 2.15(s, 6H), 3.22(s, 3H), 3.87(s, 3H),



5.18(ABq, J=12.0Hz, 2H), 6.74(dd, J=2.1, 8.1Hz, 1H), 6.78(d,



J=2.1Hz, 1H), 6.93(d, J=8.1Hz, 1H), 7.24(s, 1H), 7.30–7.50



(m, 9H)



IR(KBr)1528, 1479, 1453, 1364, 1326, 1262, 1243, 1223, 1209,



1200, 1176, 1152, 1137, 963, 870, 846, 754cm−1


I-1207
mp 108–109° C.



1HNMR(CDCl3)δ 1.77(s, 3H), 1.82(d, J=0.6Hz, 3H),



2.27(s, 3H), 2.28(s, 3H), 4.56(d, J=6.6Hz, 2H), 4.89(s, 1H),



5.54(m, 1H), 6.86–6.92(m, 2H), 6.94–7.00(m, 2H), 7.12(s, 1H),



7.13(s, 1H), 7.22–7.27(m, 2H), 7.27–7.31(m, 2H)



IR(KBr)3349, 1608, 1520, 1488, 1439, 1383, 1287, 1263, 1235,



1175, 999, 979cm−1


I-1208
mp 194–195° C.



1HNMR(CDCl3)δ 2.14(s, 3H), 2.16(s, 3H), 3.87(s, 3H),



4.97(s, 1H), 5.17(ABq, J=12.6Hz, 2H), 6.74(dd, J=2.1,



8.1Hz, 1H), 6.79(d, J=2.1Hz, 1H), 6.88–6.93(m, 2H), 6.93(d,



J=8.1Hz, 1H), 7.17–7.22(m, 2H), 7.24(s, 1H), 7.29–7.49(m, 5H)



IR(KBr)3408, 1611, 1526, 1479, 1463, 1455, 1382, 1263, 1242,



1225, 1212, 1143, 997, 751cm−1

















TABLE 239







I-1209
mp 183–184° C.



1HNMR(CDCl3)δ 2.03(s, 3H), 2.07(s, 3H), 3.19(s, 3H),



3.80(brs, 2H), 3.89(s, 3H), 5.21(s, 2H), 6.63(s, 1H), 6.77(dd,



J=2.1, 8.1Hz, 1H), 6.83(d, J=2.1Hz, 1H), 7.02(d, J=8.1Hz,



1H), 7.29–7.52(m, 9H)



IR(KBr)3481, 3391, 1610, 1511, 1482, 1370, 1240, 1212, 1197,



1173, 1153, 1137, 1024, 1007, 870, 844cm−1


I-1210
mp 133–134° C.



1HNMR(CDCl3)δ 1.75(s, 3H), 1.80(s, 3H), 2.16(s, 3H),



2.17(s, 3H), 3.22(s, 3H), 3.85(s, 3H), 4.61(d, J=6.9Hz, 2H),



5.55(m, 1H), 6.74–6.79(m, 2H), 6.92(d, J=8.7Hz, 1H),



7.24(s, 1H), 7.39(s, 4H)



IR(KBr)1529, 1516, 1478, 1371, 1353, 1328, 1263, 1242, 1201,



1176, 1150, 975, 866, 846, 787cm−1


I-1211
mp 243–244° C.



1HNMR(DMSO-d6)δ 1.91(s, 3H), 1.96(s, 3H), 3.77(s, 3H),



4.05(brs, 2H), 5.12(s, 2H), 6.40(s, 1H), 6.71(dd, J=1.8,



8.1Hz, 1H), 6.77–6.84(m, 3H), 7.06–7.12(m, 2H), 7.16(d,



J=8.1Hz, 1H), 7.32–7.52(m, 5H), 9.38(s, 1H)



IR(KBr)3378, 3289, 1609, 1586, 1518, 1483, 1454, 1402, 1267,



1236, 1207, 1171, 1136, 1024, 853, 835, 816, 753, 730,



695cm−1


I-1212
mp 195–196° C.



1HNMR(CDCl3)δ 1.75(s, 3H), 1.79(s, 3H), 2.15(s, 3H),



2.16(s, 3H), 3.85(s, 3H), 4.61(d, J=6.9Hz, 2H), 4.97(s, 1H),



5.55(m, 1H), 6.76–6.79(m, 2H), 6.89–6.94(m, 3H), 7.18–7.23



(m, 2H), 7.24(s, 1H)



IR(KBr)3462, 1611, 1519, 1479, 1459, 1431, 1379, 1271, 1240,



1228, 1211, 1137, 983, 835cm−1


I-1213
IR(KBr)3275, 1494, 1462, 1444, 1387, 1371, 1232, 1212, 1183,



1141cm−1


I-124
mp 106–108° C.



1HNMR(CDCl3)δ 2.24(s, 3H), 3.79(s, 3H), 4.72(br, 1H),



5.20(s, 2H), 6.72–7.18(m, 8H), 7.36–7.50(m, 6H)



IR(CHCl3)3596, 1610, 1523, 1493, 1465, 1455, 1388, 1318,



1298, 1262, 1173, 1127, 1038, 834cm−1

















TABLE 240







I-1215
mp 108–110° C.



1HNMR(CDCl3)δ 1.77(s, 3H), 1.82(s, 3H), 2.25(s, 3H),



3.79(s, 3H), 4.63–4.65(d, J=7.2Hz, 2H), 5.56(s, 2H), 6.81



(s, 1H), 6.87–7.18(m, 6H), 7.44–7.47(m, 2H)



IR(CHCl3)3596, 2937, 1610, 1523, 1493, 1465, 1446, 1387,



1297, 1261, 1173, 1125, 1038, 993, 834cm−1


I-1216
mp 121–122° C.



1HNMR(CDCl3)δ 2.24(s, 3H), 3.79(s, 3H), 4.78–4.80(d,



J=6.9Hz, 2H), 6.24(t, J=6.9Hz, 1H), 6.80(s, 1H), 6.87–7.19(m,



6H), 7.43–7.48(m, 2H)



IR(CHCl3)3596, 1612, 1523, 1493, 1464, 1389, 1300, 1259,



1173, 1127, 1038, 886, 834cm−1


I-1217
mp 163–165° C.



1HNMR(CDCl3)δ 2.26(s, 3H), 2.28(s, 3H), 4.78(brs, 1H),



4.78(d, J=6.5Hz, 2H), 5.60(s, 1H) 6.23(t, J=6.5Hz, 1H),



6.83–6.92(m, 4H), 6.99(d, J=2.1Hz, 1H), 7.10(s, 1H), 7.11



(s, 1H), 7.22–7.27(m, 2H)



IR(CHCl3)3597, 3548, 3027, 3010, 1613, 1588, 1522, 1490,



1218, 1208, 1171cm−1


I-1218
foam



1HNMR(CDCl3)δ 2.37(s, 3H), 3.39(s, 3H), 3.73(s, 3H),



5.15(s, 2H), 5.68(s, 1H), 5.92(s, 1H), 6.46(s, 1H), 6.71(dd,



J=3.7, 0.7Hz, 1H), 6.96(dd, J=8.4, 2.1Hz, 1H), 7.03(d,



J=8.4Hz, 1H), 7.09(d, J=2.1Hz, 1H), 7.26(dd, J=8.6,



0.7Hz, 2H), 7.37–7.45(m, 5H), 7.60(dd, J=8.7, 1.5Hz, 1H),



7.61(d, J=3.7Hz, 1H), 7.78(d, J=1.5Hz, 1H), 7.82(d,



J=8.6Hz, 1H), 8.05(d, J=8.7Hz, 1H)



IR(KBr)3476, 1457, 1371, 1254, 1107, 1131, 1107, 1011, 814,



685, 581cm−1


I-1219
mp 217–219° C.



1HNMR(CDCl3)δ 2.37(s, 3H), 2.69(s, 3H), 3.12(s, 3H),



3.47(s, 3H), 3.76(s, 3H), 5.18(s, 2H), 6.71(d, J=3.8Hz, 1H),



6.86(s, 1H), 7.15(d, J=8.4Hz, 1H), 7.26(d, J=8.7Hz, 2H),



7.32–7.48(m, 7H), 7.56(dd, J=8.7, 1.8Hz, 1H), 7.61(d,



J=3.8Hz, 1H), 7.78(d, J=1.8Hz, 1H), 7.82(d, J=8.7Hz,



1H), 8.05(d, J=8.7Hz, 1H)



IR(KBr)1366, 1174, 1079, 963, 814, 685, 586cm−1

















TABLE 241







I-1220
mp 208–210° C.



1HNMR(CDCl3)δ 2.37(s, 3H), 2.72(s, 3H), 3.23(s, 3H),



3.47(s, 3H), 3.76(s, 3H), 4.63(d, J=6.6Hz, 2H), 5.49(t, J=6.6Hz,



1H), 6.71(d, J=3.8Hz, 1H), 6.86(s, 1H), 7.09(d, J=8.4Hz, 1H),



7.26(d, J=8.3Hz, 2H), 7.35(dd, J=8.4, 2.1Hz, 1H), 7.40(d,



J=2.1Hz, 1H), 7.56(dd, J=8.4, 1.7Hz, 1H), 7.61(d, J=3.8Hz,



1H), 7.78(d, J=1.7Hz, 1H), 7.82(d, J=8.3Hz, 2H), 8.05(d,



J=8.7Hz, 1H)



IR(KBr)1466, 1445, 1365, 1174, 1116, 1079, 964, 812, 686,



584cm−1


I-1221
mp 203–205° C.



1HNMR(CDCl3)δ 1.76(s, 3H), 1.81(s, 3H), 2.39(s, 3H),



2.69(s, 3H), 2.97(t, J=8.6Hz, 2H), 3.23(s, 3H), 3.50(s, 3H),



3.77(s, 3H), 3.98(t, J=8.6Hz, 2H), 4.63(d, J=6.6Hz, 2H),



5.49(t, J=6.6Hz, 1H), 6.80(s, 1H), 7.08(d, J=8.5Hz, 1H),



7.24–7.28(m, 2H), 7.33(dd, J=8.5, 2.0Hz, 1H), 7.37–7.39



(m, 2H), 7.41–7.45(m, 1H), 7.71(d, J=8.4Hz, 1H), 7.73(d,



J=8.1Hz, 2H)



IR(KBr)1474, 1362, 1241, 1166, 1079, 975, 808cm−1


I-1222
amorphous



1HNMR(CDCl3)δ 1.76(s, 3H), 1.82(s, 3H), 2.39(s, 3H),



2.98(t, J=8.4Hz, 2H), 3.43(s, 3H), 3.73(s, 3H), 3.98(t, J=8.4Hz,



2H), 4.61(d, J=6.6Hz, 2H), 5.53(t, J=6.6Hz, 1H), 5.68(s, 1H),



5.86(s, 1H), 6.40(s, 1H), 6.93–6.95(m, 2H), 7.03–7.05(m, 1H),



7.23–7.27(m, 2H), 7.35–7.37(m, 1H), 7.45–7.50(m, 1H),



7.71(d, J=8.4Hz, 1H), 7.74(d, J=8.4Hz, 2H)



IR(KBr)3457, 1480, 1354, 1244, 1164, 1099, 978, 817cm−1


I-1223
mp 199–201° C.



1HNMR(CDCl3)δ 3.19(s, 3H), 3.72(s, 3H), 3.90(s, 3H),



4.20–4.27(m, 4H), 5.20(s, 2H), 6.53(s, 1H), 6.90–6.99(m, 3H),



7.25–7.65(m, 9H)



IR(KBr)3434, 2938, 1604, 1586, 1522, 1484, 1465, 1432, 1368,



1339, 1326, 1249, 1226, 1203, 1174, 1146, 1136, 1106,



1027cm−1

















TABLE 242







I-1224
mp 127–129° C.



1HNMR(CDCl3)δ 1.57(s, 3H), 1.65(s, 3H), 1.76(s, 3H),



1.82(s, 3H), 3.46(s, 3H), 3.64(m, 2H), 3.76(s, 3H), 4.30(t,



J=5.7Hz, 1H), 4.62(d, J=6.9Hz, 2H), 5.10(m, 1H), 5.53(m, 1H),



5.72(s, 1H), 5.85(s, 1H), 6.47(s, 1H), 6.93(dd, J=1.8, 8.4Hz,



1H), 6.98(d, J=8.4Hz, 1H), 7.05(d, J=1.8Hz, 1H), 7.88(ABq,



J=8.7Hz, 4H)



IR(KBr)3478, 3314, 2937, 1585, 1556, 1518, 1501, 1484, 1460,



1417, 1387, 1363, 1328, 1279, 1243, 1228, 1191, 1155, 1129,



1113, 1090, 1068, 1013cm−1


I-1225
mp 162–164° C.



1HNMR(CDCl3)δ 3.19(s, 3H), 3.72(s, 3H), 4.19–4.23(m, 4H),



5.18(s, 2H), 6.52(s, 1H), 7.03–7.64(m, 12H)



IR(KBr)3433, 2933, 1523, 1483, 1463, 1435, 1377, 1360, 1269,



1227, 1172, 1149, 1126, 1096cm−1


I-1226
mp 188–190° C.



1HNMR(DMSO)δ 1.72(s, 3H), 1.75(s, 3H), 3.33(s, 3H),



3.67(s, 3H), 4.55(d, J=6.9Hz, 2H), 5.49(m, 1H), 6.50(s, 1H),



6.66(dd, J=2.1, 8.1Hz, 1H), 6.74(d, J=2.1Hz, 1H), 6.91(d,



J=8.1Hz, 1H), 7.42(bs, 2H), 7.85(ABq, J=8.4Hz, 4H),



8.75(bs, 2H)



IR(KBr)3465, 2937, 1588, 1517, 1500, 1483, 1470, 1446, 1415,



1385, 1340, 1308, 1283, 1246, 1224, 1201, 1186, 1168, 1130,



1116, 1091, 1067, 1011cm−1


I-1227
mp 172–174° C.



1HNMR(CDCl3)δ 1.75(s, 3H), 1.78(s, 3H), 3.19(s, 3H),



3.72(s, 3H), 3.87(s, 3H), 4.20–4.27(m, 4H), 4.62(d, J=6.9Hz,



2H), 5.57(m, 1H), 6.54(s, 1H), 6.96(s, 3H), 7.49(ABq,



J=8.7Hz, 4H)



IR(KBr)3433, 2937, 1604, 1582, 1522, 1483, 1465, 1432, 1368,



1340, 1326, 1242, 1226, 1218, 1204, 1174, 1138, 1107cm−1

















TABLE 243







I-1228
mp 169–175° C.



1HNMR(CDCl3)δ −0.07–0.02(m, 2H), 0.34–0.42(m, 2H),



0.98(m, 1H), 2.44(s, 3H), 3.20(s, 3H), 3.47(d, J=7.2Hz, 2H),



3.78(s, 3H), 3.91(s, 3H), 5.22(s, 2H), 6.85(s, 1H), 6.91(dd,



J=1.8, 8.1Hz, 1H), 6.976(d, J=1.8Hz, 1H), 6.979(d, J=8.1Hz,



1H), 7.26–7.73(m, 9H)



IR(KBr)3447, 2934, 1604, 1518, 1480, 1390, 1362, 1240, 1227,



1175, 1140, 1081cm−1


I-1229
mp 172–174° C.



1HNMR(CDCl3)δ 1.74(s, 3H), 1.78(s, 3H), 3.71(s, 3H),



3.87(s, 3H), 4.20–4.25(m, 4H), 4.62(d, J=6.3Hz, 2H),



4.94(bs, 1H), 5.57(m, 1H), 6.55(s, 1H), 6.89–7.50(m, 7H)



IR(KBr)3410, 2933, 1611, 1522, 1484, 1462, 1422, 1371, 1264,



1238, 1224, 1173, 1134, 1103cm−1


I-1230
mp 149–151° C.



1HNMR(CDCl3)δ 1.75(s, 3H), 1.81(s, 3H), 3.45(s, 3H),



3.75(s, 3H), 3.87(s, 3H), 4.61(d, J=6.6Hz, 2H), 5.54–5.58



(m, 1H), 5.69(s, 1H), 5.91(s, 1H), 6.46(s, 1H), 6.93–7.06



(m, 5H), 7.58(d, J=8.7Hz, 2H)



IR(KBr)3501, 2939, 1680, 1609, 1582, 1520, 1487, 1458, 1397,



1284, 1246, 1191, 1179, 1115, 1067, 1015, 940, 822, 794cm−1


I-1231
mp 151–152° C.



1HNMR(CDCl3)δ 1.77(d, J=0.6Hz, 3H), 1.81(d, J=0.6Hz, 3H),



2.04(s, 3H), 2.08(s, 3H), 3.20(s, 3H), 3.77(brs, 2H), 3.86(s, 3H),



4.65(d, J=6.6Hz, 2H), 5.58(m, 1H), 6.04(s, 1H), 6.81(dd, J=2.1,



8.7Hz, 1H), 6.81(d, J=2.1Hz, 1H), 7.01(d, J=8.7Hz, 1H),



7.30–7.36(m, 2H), 7.38–7.43(m, 2H)



IR(KBr)3484, 3393, 2934, 1608, 1511, 1482, 1371, 1239, 1213,



1197, 1173, 1153, 1138, 989, 973, 871, 844, 791cm−1

















TABLE 244







I-1232
mp 198–199° C.



1HNMR(DMSO-d6)δ 1.72(s, 3H), 1.77(s, 3H), 1.91(s, 3H),



1.95(s, 3H), 3.75(s, 3H), 4.04(s, 2H), 4.55(d, J=6.9Hz, 2H),



5.48(m, 1H), 6.40(s, 1H), 6.69(dd, J=1.8, 8.1Hz, 1H), 6.75(d,



J=1.8Hz, 1H), 6.77–6.83(m, 2H), 7.05–7.11(m, 3H), 9.39(s, 1H)



IR(KBr)3375, 3287, 2913, 1609, 1587, 1578, 1518, 1484, 1434,



1403, 1270, 1235, 1207, 1171, 1136, 1032, 1009, 863, 853,



816, 749cm−1


I-1233
mp 198–199° C.



1HNMR(CDCl3)δ 1.77(s, 3H), 1.80(s, 3H), 1.91(s, 3H),



2.11(s, 3H), 2.13(s, 3H), 3.20(s, 3H), 3.84(s, 3H), 4.64(d,



J=6.6Hz, 2H), 5.58(m, 1H), 6.46(s, 1H), 6.69–6.74(m, 2H),



6.96(d, J=8.4Hz, 1H), 7.11(s, 1H), 7.32–7.38(m, 2H),



7.40–7.46(m, 2H)



IR(KBr)1651, 1513, 1470, 1448, 1414, 1368, 1330, 1267, 1241,



1214, 1199, 1175, 970, 869cm−1


I-1232
mp 193–194° C.



1HNMR(CDCl3)δ 1.77(s, 3H), 1.80(d, J=0.6Hz, 3H),



1.94(s, 3H), 2.11(s, 3H), 2.13(s, 3H), 3.84(s, 3H), 4.64(d,



J=6.6Hz, 2H), 5.58(m, 1H), 6.58(s, 1H), 6.70–6.75(m, 2H),



6.85–6.93(m, 2H), 6.96(d, J=8.4Hz, 1H), 7.13(s, 1H), 7.19–7.24



(m, 2H)



IR(KBr)3271, 1654, 1611, 1517, 1467, 1448, 1370, 1289, 1262,



1240, 1213, 1177, 1136, 835cm−1


I-1235
mp 114–115° C.



1HNMR(CDCl3)δ 1.77(s, 3H), 1.81(s, 3H), 2.27(s, 6H),



3.91(s, 3H), 4.63(d, J=6.6Hz, 2H), 5.56(m, 1H), 5.61(s, 1H),



6.86(dd, J=2.1, 8.4Hz, 1H), 6.86(d, J=2.1Hz, 1H), 6.97(d,



J=8.4Hz, 1H), 7.02–7.14(m, 5H)



IR(KBr)3410, 1597, 1521, 1470, 1449, 1415, 1382, 1297, 1276,



1261, 1220, 1122, 1052, 983, 862cm−1

















TABLE 245







I-1236
powder



1H NMR(CDCl3)δ 3.22(s, 3H), 3.38(s, 3H), 3.46(s, 3H), 3.92(s,



3H), 5.22(s, 2H), 5.76(s, 1H), 6.97–7.09(m, 3H), 7.32–7.51(m,



9H)



IR(KBr)3448, 2935, 1516, 1455, 1394, 1366, 1352, 1246,



1148, 1076, 1015, 972, 881, 699, 541, 524cm−1


I-1237
mp 169–172° C.



1H NMR(CDCl3)δ 2.49(s, 3H), 3.21(s, 3H), 3.47(s, 3H), 3.50(s,



3H), 3.92(s, 3H), 5.23(s, 2H), 6.95–7.04(m, 3H), 7.31–7.49(m,



9H)



IR(KBr)3009, 2932, 1518, 1459, 1370, 1362, 1250, 1176,



1151, 872, 809, 542, 527cm−1


I-1238 
mp 182–184° C.



1H NMR(CDCl3)δ 2.67(s, 3H), 3.21(s, 3H), 3.48(s, 3H), 3.50(s,



3H), 3.93(s, 3H), 5.77(s, 1H), 6.98–7.06(m, 3H), 7.38–7.51(m,



4H)



IR(KBr)3548, 3502, 2938, 1602, 1519, 1389, 1364, 1176,



1159, 1012, 963, 875, 521cm−1


I-1239
mp 132–135° C.



1H NMR(CDCl3)δ 1.77(s, 3H), 1.80(s, 3H), 2.62(s, 3H), 3.21(s,



3H), 3.48(s, 3H), 3.51(s, 3H), 3.90(s, 3H), 4.64(d, J=6.6Hz,



2H), 5.51–5.58(m, 1H), 6.97–7.04(m, 3H), 7.37–7.51(m, 4H)



IR(KBr)2936, 1518, 1464, 1375, 1362, 1246, 1175, 1153,



1013, 968, 872, 805, 529cm−1


I-1240
mp 169–172° C.



1H NMR(CDCl3)δ 1.76(s, 3H), 1.80(s, 3H), 3.38(s, 3H), 3.47(s,



3H), 3.89(s, 3H), 4.65(d, J=6.6Hz, 2H), 5.06(s, 1H), 5.54–5.61



(m, 1H), 5.83(s, 1H), 6.92–7.00(m, 3H), 7.05–7.09(m, 2H),



7.28–7.33(m, 2H)



IR(KBr)3458, 2935, 1611, 1520, 1458, 1392, 1244, 1222,



1015, 828, 803cm−1

















TABLE 246







I-1241
mp 170–173° C.



1H NMR(CDCl3)δ 1.73(s, 3H), 1.79(s, 3H), 2.55–3.00(m, 3H),



3.21(s, 3H), 3.22–3.80(m, 6H), 4.55–4.63(m, 2H), 5.41–5.47



(m, 1H), 6.83(s, 1H), 7.03–7.70(m, 8H)



IR(KBr)2938, 1686, 1516, 1481, 1378, 1235, 1235, 1179, 1152,



1081, 847, 799, 675, 527cm−1


I-1242
mp 117–118° C.



1H NMR(CDCl3)δ 1.77(s, 3H)1.81(d, J=0.6Hz, 3H), 2.11(s,



3H), 2.19(s, 3H), 3.38(s, 3H), 4.64(d, J=6.9Hz, 2H), 4.75(br s,



1H), 5.54–5.90(m, 1H), 6.86–6.91(m, 2H), 6.93(s, 1H), 7.10–



7.69(m, 3H), 7.20–7.25(m, 2H)



IR(CHCl3)3596, 3010, 2934, 1675, 1519, 1473, 1262, 1172,



1098cm−1


I-1243
foam



1H NMR(CDCl3)δ 3.43(s, 3H), 3.72(s, 3H), 5.03(s, 2H), 6.43(s,



1H), 6.93(dd, J=8.4, 2.1Hz, 1H), 6.94(d, J=8.7Hz, 2H), 7.09(d,



J=2.1Hz, 1H), 7.11(d, J=8.4Hz, 1H), 7.29(ddd, J=7.8, 4.8,



1.5Hz, 1H), 7.49(brd, J=7.8Hz, 1H), 7.53(d, J=8.7Hz, 2H),



7.70(ddd, J=7.8, 7.8, 1.5Hz, 1H), 8.61(brd, J=4.8Hz, 1H)



IR(KBr)3432, 1611, 1588, 1562, 1523, 1488, 1467, 1226, 1114,



1071, 1015, 939, 824, 778, 758cm−1


I-1244
foam



1H NMR(CDCl3)δ 3.45(s, 3H), 3.75(s, 3H), 5.01(s, 2H), 6.45(s,



1H), 6.92(d, J=8.7Hz, 2H), 6.99(dd, J=8.4, 2.1Hz, 1H), 7.10(d,



J=2.1Hz, 1H), 7.14(d, J=8.4Hz, 1H), 7.30~7.36(m, 3H),



7.46~7.49(m, 2H), 7.54(d, J=8.7Hz, 2H)



IR(KBr)3433, 1612, 1589, 1523, 1489, 1403, 1224, 1192, 1113,



1070, 1013, 938, 813, 758cm−1


I-1245
foam



1H NMR(CDCl3)δ 3.45(s, 3H), 3.75(s, 3H), 5.01(s, 2H), 6.45(s,



1H), 6.92(d, J=8.7Hz, 2H), 6.99(dd, J=5.1, 3.6Hz, 1H), 6.99(dd,



J=8.4, 2.1Hz, 1H), 7.10(d, J=2.1Hz, 1H), 7.11(d, J=8.4Hz,



1H), 7.27(dd, J=3.6, 1.0Hz, 1H), 7.29(dd, J=5.1, 1.0Hz, 1H),



7.54(d, J=8.7Hz, 2H)



IR(KBr)3433, 1612, 1589, 1523, 1488, 1403, 1241, 1224, 1192,



1113, 1070, 1011, 826cm−1

















TABLE 247







I-1246
foam



1H NMR(CDCl3)δ 3.45(s, 3H), 3.75(s, 3H), 4.93(s, 2H), 5.70(d,



J=1.5Hz, 1H), 5.75(d, J=1.5Hz, 1H), 6.45(s, 1H), 6.92(d, J=



8.7Hz, 2H), 6.99(dd, J=8.4, 2.1Hz, 1H), 7.05(d, J=8.4Hz, 1H),



7.10(d, J=2.1Hz, 1H), 7.54(d, J=8.7Hz, 2H)



IR(KBr)3432, 1611, 1590, 1523, 1489, 1403, 1224, 1193, 1113,



1071, 1010, 938, 826cm−1


I-1247
foam



1H NMR(CDCl3)δ 3.45(s, 3H), 3.75(s, 3H), 5.53(d, J=10.5Hz,



1H), 5.69(d, J=16.5Hz, 1H), 6.11(ddd, J=16.5, 10.5, 6.3Hz,



1H), 6.44(d, J=6.3Hz, 1H), 6.45(s, 1H), 6.88(d, J=8.4Hz, 1H),



6.91~6.93(m, 2H), 6.92(d, J=8.7Hz, 2H), 7.53(d, J=8.7Hz, 2H)



IR(KBr)3433, 1611, 1592, 1522, 1485, 1403, 1226, 1106, 1059,



814cm−1


I-1248
foam



1H NMR(CDCl3)δ 1.16(t, J=7.5Hz, 3H), 2.26(tq, J=2.1, 7.5Hz,



2H), 3.45(s, 3H), 3.75(s, 3H), 4.76(t, J=2.1Hz, 2H), 6.45(s, 1H),



6.91(d, J=8.7Hz, 2H), 6.96(dd, J=2.1, 8.4Hz, 1H), 7.06(d, J=



8.4Hz, 1H), 7.07(d, J=2.1Hz, 1H), 7.53(d, J=8.7Hz, 2H)



IR(KBr)3434, 2230, 1612, 1590, 1523, 1479, 1225, 1113, 1070,



1005, 938, 815cm−1


I-1249
foam



1H NMR(CDCl3)δ 3.38(s, 3H), 3.67(s, 3H), 5.12(s, 2H), 6.43(s,



1H), 6.56(d, J=3.3Hz, 1H), 6.79(dd, J=2.1, 8.1Hz, 1H), 6.84(d,



J=8.7Hz, 2H), 6.87(d, J=2.1Hz, 1H), 7.02(d, J=3.3Hz, 1H),



7.02(d, J=8.1Hz, 1H), 7.45(d, J=8.7Hz, 2H)



IR(KBr)3431, 1698, 1611, 1523, 1489, 1405, 1246, 1114, 1071,



1012, 816, 786cm−1


I-1250
1H NMR(CDCl3)δ 3.38(s, 3H), 3.67(s, 3H), 4.66(tt, J=2.7,



6.9Hz, 2H), 4.90(tt, J=2.7, 6.9Hz, 2H), 5.43(tt, J=6.9, 6.9Hz,



1H), 6.45(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.96(br.s, 2H), 7.07(s,



1H), 7.53(d, J=8.7Hz, 2H)



IR(KBr)3430, 1955, 1612, 1589, 1522, 1489, 1404, 1248, 1113,



1070, 1008, 938, 845, 825cm−1

















TABLE 248







I-1251
foam



1H NMR(CDCl3)δ 1.69(dd, J=3.3, 6.9Hz, 3H), 3.46(s, 3H), 3.74



(s, 3H), 4.63(dd, J=2.4, 6.3Hz, 2H), 5.28(m, 1H), 5.33(m, 1H),



6.45(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.95(d, J=1.5Hz, 1H), 6.96



(br.s, 1H), 7.06(d, J=1.5Hz, 1H), 7.52(d, J=8.7Hz, 2H)



IR(KBr)3436, 2933, 1968, 1612, 1587, 1523, 1489, 1464, 1404,



1112, 1071, 1011, 998, 824cm−1


I-1252
foam



1H NMR(CDCl3)δ 1.02(t, J=7.2Hz, 3H), 2.05(ddq, J=3.3, 6.3,



7.2Hz, 2H), 3.46(s, 3H), 3.74(s, 3H), 4.64(dd, J=2.4, 6.0Hz,



2H), 5.40(m, 2H), 6.45(s, 1H), 6.91(d, J=8.7Hz, 2H), 6.94(d,



J=2.1, 8.4Hz, 1H), 6.97(d, J=8.4Hz, 1H), 7.06(d, J=2.1Hz,



1H), 7.54(d, J=8.7Hz, 2H)



IR(KBr)3479, 2960, 2933, 1964, 1612, 1582, 1522, 1489, 1403,



1242, 1113, 1072, 1011, 999, 944, 872cm−1


I-1253
foam



1H NMR(CDCl3)δ 1.03(d, J=6.6Hz, 6H), 2.34(m, 1H), 3.46(s,



3H), 3.74(s, 3H), 4.63(dd, J=2.7, 6.3Hz, 2H), 5.33(m, 1H),



5.44(m, 1H), 6.45(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.93(d, J=1.8,



7.8Hz, 1H), 6.97(d, J=7.8Hz, 1H), 7.06(d, J=1.8Hz, 1H), 7.53



(d, J=8.7Hz, 2H)



IR(KBr)3434, 2958, 1960, 1612, 1589, 1523, 1489, 1226, 1113,



1071, 1011, 939, 825cm−1


I-124
foam



1H NMR(CDCl3)δ 2.62(d, J=2.4Hz, 1H), 3.45(s, 3H), 3.75(s,



3H), 4.18(dd, J=7.2, 11.4Hz, 1H), 4.38(dd, J=2.4, 11.4Hz, 1H),



4.94(ddd, J=2.4, 2.4, 7.2Hz, 1H), 6.44(s, 1H), 6.92(d, J=8.7Hz,



2H), 6.98(d, J=8.4Hz, 1H), 7.01(d, J=1.8, 8.4Hz, 1H), 7.08(d,



J=1.8Hz, 1H), 7.52(d, J=8.7Hz, 2H)



IR(KBr)3434, 3283, 2127, 1612, 1586, 15323, 1487, 1226,



1115, 1069, 1007, 943, 825cm−1

















TABLE 249







I-1255
mp 148–150° C.



1H NMR(CDCl3)δ 2.99(s, 6H), 3.75–3.80(br, 2H), 3.75(s, 3H),



3.77(s, 3H), 6.45–6.53(m, 2H), 6.79–6.83(m, 2H), 6.88(s, 1H),



6.95(s, 1H), 7.17–7.23(m, 1H), 7.48–7.51(m, 2H)



IR(KBr)3600–2800(br), 1630, 1609, 1530, 1492, 1461, 1444,



1388, 1331, 1209, 1165, 1125, 1050, 1028cm−1


I-1256
mp 209–212° C.



1H NMR(CDCl3)δ 3.00(s, 6H), 3.11(s, 3H), 3.76(s, 3H), 3.79(s,



3H), 6.66(br s, 1H), 6.78–6.83(m, 2H), 6.87(s, 1H), 6.98(s, 1H),



7.02(dd, J=2.4, 8.4Hz, 1H), 7.10(dd, J=2.4, 10.8Hz, 1H),



7.39–7.52(m, 3H)



IR(KBr)3600–2800(br), 1627, 1609, 1530, 1494, 1463, 1390,



1325, 1213, 1154, 1127, 1052, 1028, 984cm−1


I-1257
mp 198–200° C.



1H NMR(CDCl3)δ 1.43(t, J=7.5Hz, 3H), 3.00(s, 3H), 3.19–



3.26(m, 2H), 3.76(s, 3H), 3.79(s, 3H), 6.69(br s, 1H), 6.79–



6.85(m, 2H), 6.86(s, 1H), 6.97(s, 1H), 7.01(dd, J=2.4, 8.4Hz,



1H), 7.09(dd, J=2.4, 10.8Hz, 1H), 7.37–7.53(m, 3H)



IR(KBr)3600–2800(br), 1611, 1530, 1492, 1495, 1445, 1389,



1355, 1325, 1207, 1163, 1141, 1122, 1051, 1025, 981cm−1


I-1258
IR(KBr)1612, 1526, 1490, 1444, 1349, 1301, 1196, 1129, 1038



cm−1



mp 102–103° C.



1H NMR(CDCl3)δ 2.27(s, 3H), 2.31(s, 3H), 3.00(s, 6H), 4.78(d,



J=6.6Hz, 2H), 6.24(t, J=6.6Hz, 1H), 6.80(d, J=8.4Hz, 2H),



6.96–7.16(m, 5H), 7.26(d, J=8.4Hz, 2H)


I-1259
mp 114–115° C.



1H NMR(CDCl3)δ 1.75(s, 3H), 1.79(s, 3H), 3.61(s, 3H), 3.65(s,



3H), 3.74(s, 3H), 3.87(s, 3H), 3.88(s, 3H), 4.63(d, J=6.9Hz,



2H), 5.54–5.62(m, 1H), 6.68(s, 1H), 6.94–7.03(m, 5H),



7.54(d, J=9.0Hz, 2H)



IR(KBr)3433, 2932, 1682, 1605, 1580, 1519, 1465, 1439, 1389,



1290, 1253, 1237, 1186, 1140, 1109, 1089, 1039, 1029, 992,



833cm−1

















TABLE 250







I-1260
mp 163–165° C.



1H NMR(CDCl3)δ 1.76(s, 3H), 1.81(s, 3H), 3.19(s, 3H), 3.72(s,



3H), 4.20–4.26(m, 4H), 4.62(d, J=6.6Hz, 2H), 5.55(m, 1H),



6.53(s, 1H), 7.00–7.20(m, 3H), 7.49(ABq, J=8.1Hz, 4H)



IR(KBr)3433, 2933, 1523, 1483, 1463, 1433, 1371, 1359, 1340,



1299, 1266, 1227, 1220, 1172, 1149, 1127, 1098cm−1


I-1261
mp 135–137° C.



1H NMR(CDCl3)δ −0.03–0.03(m, 2H), 0.36–0.42(m, 2H),



1.00(m, 1H), 1.75(s, 3H), 1.79(s, 3H), 2.56(s, 3H), 3.20(s, 3H),



3.48(d, J=4.8Hz, 2H), 3.78(s, 3H), 3.88(s, 3H), 4.63(d, J=



6.9Hz, 2H), 5.54(m, 1H), 6.86(s, 1H), 6.95–6.97(m, 3H), 7.55



(ABq, J=8.7Hz, 4H)



IR(KBr)3433, 2936, 1604, 1519, 1481, 1467, 1369, 1336, 1245,



1231, 1201, 1177, 1153, 1081cm−1


I-1262
mp 181–182° C.



1H NMR(CDCl3)δ 1.76(s, 3H), 1.80(s, 3H), 3.72(s, 3H), 4.19–



4.26(m, 4H), 4.62(d, J=6.9Hz, 2H), 4.91(bs, 1H), 5.55(m, 1H),



6.53(s, 1H), 6.89–7.49(m, 7H)



IR(KBr)3404, 1612, 1523, 1485, 1462, 1434, 1373, 1266, 1227,



1212, 1116, 1101cm−1


I-1263
mp 80–82° C.



1H NMR(CDCl3)δ −0.05–0.09(m, 2H), 0.44–0.51(m, 2H), 1.04



(m., 1H), 1.74(s, 3H), 1.78(s, 3H), 3.33(d, J=4.8Hz, 2H), 3.75(s,



3H), 3.88(s, 3H), 4.63(d, J=6.6Hz, 2H), 4.98(s, 1H), 5.57(m,



1H), 6.15(s, 1H), 6.46(s, 1H), 6.89–7.03(m, 5H), 7.52–7.56(m,



2H)



IR(KBr)3374, 1614, 1523, 1490, 1465, 1446, 1391, 1267, 1235,



1172, 1113, 1073cm−1


I-1264
mp 112–113° C.



1H NMR(CDCl3)δ 2.19(s, 3H), 2.28(s, 3H), 3.91(s, 3H), 5.20(s,



2H), 6.84–6.86(m, 1H), 6.92–6.97(m, 2H), 7.09(s, 1H), 7.16(s,



1H), 7.31–7.43(m, 5H), 7.47–7.49(m, 2H), 7.60(d, J=10.2Hz,



1H), 8.01(brs, 1H)



IR(KBr)3421, 3303, 2935, 1711, 1519, 1490, 1365, 1231, 1198,



1178, 1134, 1109, 864cm−1

















TABLE 251







I-1265
mp 85–86° C.



1H NMR(CDCl3)δ 2.85(s, 3H), 3.32(s, 3H), 3.82(s, 3H), 3.96(s,



3H), 5.38(s, 2H), 7.04(s, 1H), 7.22(s, 1H), 7.25(d, J=8.4Hz,



1H), 7.35(d, J=8.4Hz, 1H), 7.48–7.67(m, 7H), 8.45(brs, 1H)



IR(KBr)3432, 2938, 1740, 1608, 1517, 1483, 1396, 1366, 1271,



1179, 1111, 1080, 832, 810, 698cm−1


I-1266
mp 79–80° C.



1H NMR(CDCl3)δ 2.14(s, 3H), 3.50(s, 3H), 4.95(brs, 1H), 5.22



(s, 2H), 2H), 7.02–7.11(m, 3H), 7.37–7.56(m, 7H)



IR(KBr)3409, 2933, 1612, 1522, 1488, 1454, 1400, 1266, 1229,



1199, 1162, 1007, 834, 696cm−1


I-1267
mp 87–88° C.



1H NMR(CDCl3)δ 2.13(s, 3H), 2.59(s, 3H), 3.20(s, 3H), 3.55(s,



3H), 5.22(s, 2H), 6.99–7.17(m, 5H), 7.34–7.48(m, 6H), 7.67(d,



J=8.4Hz, 2H)



IR(KBr)3428, 2931, 1612, 1522, 1488, 1454, 1400, 1266, 1230,



1163, 1007, 835cm−1


I-1268
mp 76–77° C.



1H NMR(CDCl3)δ 1.72(s, 3H), 1.77(s, 6H), 1.81(s, 3H), 2.69(s,



3H), 3.24(s, 3H), 3.61(s, 3H), 3.79(s, 3H), 4.12–4.20(m, 1H),



4.55–4.6 1(m, 1H), 4.64(d, J=6.6Hz, 2H), 5.25(t, J=7.5Hz,



1H), 5.50(t, J=6.4Hz, 1H), 6.85(s, 1H), 7.05–7.11(m, 2H),



7.34–7.40(m, 3H)



IR(KBr)3423, 2939, 1707, 1521, 1484, 1367, 1241, 1178, 1079,



1034, 972, 799, 521cm−1


I-1269
mp 73–74° C.



1H NMR(CDCl3)δ 2.17(s, 3H), 2.28(s, 3H), 5.16(s, 2H), 5.71



(brs, 1H), 6.83(d, J=8.1Hz, 1H), 6.97–7.00(m, 2H), 7.08(s, 1H),



7.15(s, 1H), 7.32–7.33(m, 2H), 7.36–7.45(m, 5H), 7.60(d, J=



10.5Hz, 1H), 8.05(brs, 1H)



IR(KBr)3410, 2923, 1718, 1606, 1540, 1521, 1489, 1424, 1282,



1179, 976, 728cm−1

















TABLE 252







I-1270
mp 65–67° C.



1H NMR(CDCl3)δ 1.77(s, 3H), 1.81(s, 3H), 2.14(s, 3H), 2.72(s,



3H), 3.20(s, 3H), 3.56(s, 3H), 4.64(d, J=6.9Hz, 2H), 5.53(t, J=



6.6Hz, 1H), 7.01–7.11(m, 3H), 7.18(s, 1H), 7.37(d, J=8.7Hz,



2H), 7.67(d, J=8.7Hz, 2H),.



IR(KBr)3434, 2938, 1519, 1478, 1365, 1267, 1176, 1151, 968,



871, 799, 524cm−1


I-1271
mp 99–100° C.



1H NMR(CDCl3)δ 1.76(s, 6H), 1.79(s, 3H), 1.81(s, 3H), 3.52(s,



3H), 3.72(s, 3H), 4.61(d, J=7.2Hz, 2H), 5.36(t, J=6.6Hz, 1H),



5.53(t, J=5.7Hz, 1H), 5.69(brs, 1H), 5.81(brs, 1H), 6.43(s, 1H),



6.46–6.52(m, 1H), 6.95(s, 2H), 7.05(s, 1H), 7.10–7.16(m, 1H)



IR(KBr)3496, 3407, 2933, 1638, 1535, 1493, 1098, 1000cm−1


I-1272
mp 75–76° C.



1H NMR(CDCl3)δ 2.17(s, 3H), 2.28(s, 3H), 3.12(s, 3H), 5.18(s,



2H), 7.09–7.14(m, 4H), 7.26–7.47(m, 8H), 7.61(d, J=11.4Hz,



1H), 8.00(brs, 1H)



IR(KBr)3330, 2927, 1731, 1607, 1541, 1521, 1488, 1364, 1290,



1169, 1105, 975, 878, 811cm−1


I-1273
mp 112–113° C.



1H NMR(CDCl3)δ 1.76(s, 3H), 1.81(s, 3H), 2.11(s, 3H), 3.47(s,



3H), 4.64(d, J=6.6Hz, 2H), 4.83(brs, 1H), 5.56(t, J=7.2Hz,



1H), 5.84(brs, 1H), 6.78(s, 1H), 6.91(d, J=8.7Hz, 2H),



7.02–7.10(m, 3H), 751(d, J=8.4Hz, 2H).,



IR(KJ3r)3498, 2978, 1613, 1522, 1487, 1453, 1302, 1204, 1232,



1196, 987, 812cm−1


I-1274
oil



1H NMR(CDCl3)δ 1.73(s, 3H), 1.76(s, 3H), 1.77(s, 3H), 1.79(s,



3H), 2.22(s, 3H), 2.27(s, 3H), 3.73(d, J=6.0Hz, 2H), 3.88(s,



3H), 4.63(d, J=6.6Hz, 2H), 5.36(t, J=6.0Hz,1H), 5.57(t,



J=6.6Hz, 1H), 6.40–6.51(m, 2H), 6.87–6.95(m, 3H),



7.05–7.14(m, 3H)



IR(CHCl3)3021, 2934, 1628, 1523, 1492, 1235, 1219, 1139



cm−1

















TABLE 253







I-1275
mp 64–65° C.



1H NMR(CDCl3)δ 1.74(s, 3H), 1.77(s, 6H), 1.82(s, 3H), 2.16(s,



3H), 2.29(s, 3H), 3.23(s, 3H), 4.36(d, J=7.5Hz, 2H), 4.64(d,



J=6.3Hz, 2H), 5.28(t, J=8.4Hz, 1H), 5.51(t, J=6.3Hz, 1H),



7.01–7.16(m, 6H), 7.24–7.35(m, 2H)



IR(KBr)3422, 2926, 1698, 1519, 1489, 1367, 1209, 1170, 962,



807cm−1


I-1276
oil



1H NMR(CDCl3)δ 2.21(s, 3H), 2.26(s, 3H), 3.95(d, J=6.6Hz,



2H), 4.28(brs, 1H), 4.78(d, J=6.0Hz, 2H), 6.05(t, J=6.3Hz, 1H),



6.24(t, J=6.3Hz, 1H), 6.36–6.49(m, 2H), 6.97–7.15(m, 6H)



IR(CHCl3)3446, 3009, 1628, 1525, 1492, 1274, 1224,



1130, 883cm−1


I-1277
mp 64–65° C.



1H NMR(CDCl3)δ 1.76(s, 3H), 1.80(s, 6H), 1.85(s, 3H), 2.23(s,



3H), 2.30(s, 3H), 3.74(d, J=6.3Hz, 2H), 4.64(d, J=6.0Hz, 2H),



5.38(t, J=6.6Hz, 1H), 5.55(t, J=6.9Hz, 1H), 5.73(brs, 1H),



6.41–6.50(m, 2H), 6.84–7.15(m, 6H)



IR(KBr)3354, 2971, 1627, 1522, 1490, 1274, 1200, 1128,



990, 843cm−1


I-1278
mp 153–154° C.



1H NMR(CDCl3)δ 1.77(s, 3H), 1.82(s, 3H), 1.95(s, 12H),



4.64(d, J=6.9Hz, 2H), 4.78(s, 1H), 5.57(t, J=6.9Hz, 1H),



6.85(ddd, J=8.3, 2.1, 1.2Hz, 1H), 6.90(d, J=8.6Hz, 2H),



6.92(dd, J=12.0, 2.1Hz, 1H), 7.04(d, J=8.6Hz, 2H), 7.04(t,



J=8.3Hz, 1H),



IR(KBr)3433, 1514, 1293, 1262, 1242, 1112, 984cm−1


I-1279
mp 115–117° C.



1H NMR(CDCl3)δ 1.76(s, 3H), 1.81(s, 3H), 2.23(s, 3H), 3.21(s,



3H), 3.81(s, 3H), 4.63(d, J=6.6Hz, 2H), 5.55(t, J=6.6Hz, 1H),



6.81(s, 1H), 7.02(t, J=8.6Hz, 1H), 7.20(s, 1H), 7.24–7.28(m,



1H), 7.33–7.44(m, 3H)



IR(KBr)3434, 1522, 1492, 1337, 1218, 1200, 1148, 979,



876cm−1

















TABLE 254







I-1280
mp 88–90° C.



1H NMR(CDCl3)δ 1.76(s, 3H), 1.80(s, 3H), 2.24(s, 3H), 3.80(s,



3H), 4.63(d, J=6.7Hz, 2H), 4.88(br s, 1H), 5.55(t, J=6.7Hz,



1H), 6.83(s, 1H), 6.90(d, J=8.7Hz, 2H), 7.01(t, J=8.6Hz, 1H),



7.18(s, 1H), 7.24–7.28(m, 3H), 7.36(dd, J=12.9, 2.1Hz, 1H)



IR(KBr)3400, 1523, 1493, 1263, 1217, 1128, 977, 836cm−1


I-1281
mp 158–159° C.



1H NMR(CDCl3)δ 1.76(s, 3H), 1.80(d, J=0.3Hz, 3H), 2.10(s,



3H), 2.34(s, 3H), 2.50(s, 3H), 3.87(s, 3H), 4.63(d, J=6.9Hz,



2H), 5.14(s, 1H), 5.55(m, 1H), 5.88(s, 1H), 6.77–6.82(m, 2H),



6.85–6.91(m, 2H), 6.98(d, J=8.1Hz, 1H), 7.13(s, 1H),



7.18–7.24(m, 2H)



IR(KBr)3465, 1610, 1516, 1473, 1382, 1322, 1307, 1266, 1240,



1213, 1179, 1168, 1147, 1100, 982, 836cm−1


I-1282
mp 85–86° C.



1H NMR(CDCl3)δ 0.99(d, J=6.2Hz, 6H), 1.71–1.98(m, 3H),



2.27(s, 3H), 2.29(s, 3H), 3.20(s, 3H), 3.88(s, 3H), 4.10(t, J=



6.8Hz, 2H), 6.88(dd, J=2.0, 8.6Hz, 1H), 6.88(d, J=2.0Hz, 1H),



6.95(d, J=8.6Hz, 1H), 7.30–7.46(m, 4H)



IR(KBr)1519, 1488, 1375, 1255, 1243, 1214, 1204, 1173, 1154,



1134, 867, 850, 792cm−1


I-1283
mp 117–118° C.



1H NMR(CDCl3)δ 0.99(d, J=6.3Hz, 6H), 1.75–1.94(m, 3H),



2.27(s, 3H), 2.28(s, 3H), 3.88(s, 3H), 4.10(t, J=6.6Hz, 2H),



4.91(s, 1H), 6.86–6.91(m, 4H), 6.94(d, J=8.7Hz, 1H), 7.12(s,



1H), 7.15(s, 1H), 7.22–7.27(m, 2H)



IR(KBr)3438, 1611, 1522, 1490, 1475, 1464, 1446, 1256, 1242,



1212, 1180, 1171, 1137, 1032, 834, 818cm−1


I-1284
mp 156–157° C.



1H NMR(CDCl3)δ 3.46(s, 3H), 3.76(s, 3H), 3.89(s, 3H),



4.78(d, J=6.3Hz, 2H), 4.99(s, 1H), 5.96(s, 1H), 6.25(t, J=6.3Hz,



1H), 6.47(s, 1H), 6.90–6.95(m, 2H), 6.93(d, J=7.8Hz, 1H),



7.04(dd, J=2.1, 7.8Hz, 1H), 7.04(d, J=2.1Hz, 1H),



7.51–7.57(m, 2H)



IR(KBr)3455, 1612, 1522, 1487, 1456, 1396, 1269, 1234, 1223,



1209, 1173, 1140, 1115, 1024, 885, 825, 813cm−1

















TABLE 255







I-1285
mp 84–85° C.



1H NMR(CDCl3)δ 1.00(d, J=6.6Hz, 6H), 1.71–1.96(m, 3H),



2.27(s, 6H), 4.11(t, J=6.9Hz, 2H), 4.80(br s, 1H), 6.86–6.92(m,



2H), 6.97–7.14(m, 5H), 7.22–7.27(m, 2H)



IR(KBr)3389, 1523, 1491, 1476, 1427, 1301, 1276, 1233, 1196,



1168, 1126, 836, 815cm−1


I-1286
mp 152–153° C.



1H NMR(CDCl3)δ 1.76(s, 3H), 1.80(d, J=0.6Hz, 3H), 2.12(s,



3H), 2.20(s, 3H), 3.39(s, 3H), 3.87(s, 3H), 4.64(d, J=6.3Hz,



2H), 4.79(br s, 1H), 5.56–5.61(m, 1H), 6.82–6.97(m, 6H),



7.21–7.26(m, 2H)



IR(CHCl3)3596, 3440, 3011, 2935, 1676, 1612, 1588,



1518, 1473, 1449, 1259, 1238, 1173cm−1


I-1287
mp 123–125° C.



1H NMR(CDCl3)δ −0.01–0.08(m, 2H), 0.44–0.50(m, 2H), 1.01



(m, 1H), 3.21(s, 3H), 3.34(d, J=7.5Hz, 2H), 3.75(s, 3H), 3.91(s,



3H), 5.21(s, 2H), 6.08(s, 1H), 6.45(s, 1H), 6.97–7.04(m, 3H),



7.26–7.72(m, 9H)


I-1288
mp 177–178° C.



1H NMR(CDCl3)δ 0.27(t, J=4.8Hz, 1H), 0.60(dd, J=4.8, 8.7Hz,



1H), 1.13(s, 3H), 1.17(s, 3H), 1.13–1.22(m, 1H), 3.46(s, 3H),



3.75(s, 3H), 3.80(s, 3H), 4.00(dd, J=7.8, 10.5Hz, 1H), 4.12(dd,



J=6.6, 10.5Hz, 1H), 4.95(bs, 1H), 5.91(s, 1H), 6.46(s, 1H),



6.91–7.02(m, 5H), 7.52–7.56(m, 2H)



IR(KBr)3479, 3434, 3389, 2940, 1614, 1589, 1523, 1490, 1466,



1395, 1361, 1319, 1271, 1238, 1218, 1174, 1137, 1117, 1072,



1011cm−1


I-1289
mp 153–155° C.



1H NMR(CDCl3)δ 1.76(s, 3H), 1.80(s, 3H), 2.25(s, 3H), 3.80(s,



3H), 3.89(s, 3H), 4.63–4.65(d, J=6.6Hz, 2H), 4.80(br, 1H),



5.57(m, 1H), 6.86–6.97(m, 6H), 7.18(s, 1H), 7.45–7.48(m, 2H)



IR(CHCl3)3596, 1609, 1523, 1493, 1464, 1387, 1256,



1173, 1138, 1042, 1032, 997, 834cm−1

















TABLE 256







I-1290
mp 150–152° C.



1H NMR(CDCl3)δ 2.25(s, 3H), 3.80(s, 3H), 3.90(s, 3H), 4.74–



4.80(m, 3H), 6.26(t, J=6.0Hz, 1H), 6.85–6.92(m, 6H), 7.19(s,



1H), 7.45–7.48(m, 2H)



IR(CHCl3)3596, 2958, 2938, 1609, 1523, 1493, 1464, 1389,



1328, 1257, 1173, 1140, 1102, 1030, 886, 854, 834cm−1


I-1291
mp 117–118° C.



1H NMR(CDCl3)δ 1.76(s,3H), 1.79(s, 3H), 2.28(s, 3H), 2.31(s,



3H), 3.01(s, 6H), 3.88(s, 3H), 4.63(d, J=6.6Hz, 2H), 5.53–



5.60(m, 1H), 6.76–6.96(m, 5H), 7.15(s, 2H), 7.28(d, J=8.7Hz,



2H)



IR(KBr)1611, 1529, 1490, 1447, 1359, 1322, 1239, 1214, 1193,



1135, 1038,cm−1


I-1292
mp 116–118° C.



1H NMR(CDCl3)2.24(s, 3H), 3.81(s, 3H), 4.77(d, J=6.3Hz, 2H),



4.90(br s, 1H), 6.23(t, J=6.3Hz, 1H), 6.83(s, 1H), 6.90(d, J=



8.7Hz, 2H), 6.99(t, J=8.6Hz, JH), 7.17(s, 1H), 7.25(d, J=8.7Hz,



2H), 7.27(ddd, J=8.6, 2.1, 1.2Hz, 1H), 7.37(dd, J=12.6, 2.1Hz,



1H)



IR(KBr)3596, 1731, 1613, 1523, 1493, 1259, 1130, 1033, 885



cm−1


I-1293
mp 151–154° C.



1H NMR(CDCl3)δ 2.23(s, 3H), 3.21(s, 3H), 3.80(s, 3H), 3.93(s,



3H), 5.20(s, 2H), 6.81(s, 1H), 6.95(d, J=8.4Hz, 1H), 7.05(dd, J=



8.4, 2.1Hz, 1H), 7.15(s, J=2.1Hz, 1H), 7.21(s, 1H), 7.30–



7.50(m, 9H)



IR(KBr)1490, 1361, 1243, 1148, 1032, 876cm−1


I-1294
mp 119–121° C.



1H NMR(CDCl3)δ 1.76(s, 3H), 1.79(s, 3H), 2.24(s, 3H), 3.21(s,



3H), 3.80(s, 3H), 3.91(s, 3H), 4.63(d, J=6.5Hz, 2H), 5.56(t, J=



6.5Hz, 1H), 6.82(s, 1H), 6.94(d, J=8.4Hz, 1H), 7.10(dd, J=8.4,



1.5Hz, 1H), 7.13(d, J=1.5Hz, 1H), 7.23(s, 1H), 7.36(d, J=8.3Hz,



2H), 7.43(d, J=8.3Hz, 2H)



IR(KBr)1519, 1490, 1364, 1156, 1031, 971, 858cm−1

















TABLE 257







I-1295
mp 135–137° C.



1H NMR(CDCl3)δ 1.75(s, 3H), 1.78(s, 3H), 2.25(s, 3H), 3.80(s,



3H), 3.90(s, 3H), 4.63(d, J=6.7Hz, 2H), 4.95(s, 1H), 5.56(t, J=



6.7Hz, 1H), 6.84(s, 1H), 6.90(d, J=8.7Hz, 2H), 6.94(d, J=8.3Hz,



1H), 7.10(dd, J=8.3, 2.1Hz, 1H), 7.13(d, J=2.1Hz, 1H), 7.21(s,



1H), 7.26(d, J=8.7Hz, 2H)



IR(KBr)3423, 1609, 1523, 1493, 1258, 1219, 1142, 1033, 834



cm−1


I-1296
mp 140–141° C.



1H NMR(CDCl3)δ 1.46(t, J=6.9Hz, 3H), 3.46(s, 3H), 3.75(s,



3H), 4.13(q, J=6.9Hz, 2H), 4.77(d, J=6.0Hz, 2H), 5.05(s, 1H),



5.95(s, 1H), 6.25(t, J=6.0Hz, 1H), 6.47(s, 1H), 6.90–6.97(m,



3H), 7.01–7.06(m, 2H), 7.50–7.57(m, 2H)



IR(KBr)3463, 3433, 1613, 1521, 1491, 1259, 1400, 1267, 1235,



1204, 1167, 1136, 1112, 1097, 1076, 1019, 993, 882, 824,



811cm−1


I-1297
mp 204–205° C.



1H NMR(DMSO-d6)δ 2.21(s, 3H), 2.22(s, 3H), 2.87(s, 3H),



3.02(s, 3H), 4.96(s, 2H), 6.80–6.86(m, 2H), 7.05–7.11(m,



4H), 7.13–7.19(m, 2H), 7.20–7.27(m, 1H)



IR(KBr)3153, 1644, 1590, 1522, 1487, 1437, 1314, 1264, 1231,



1197, 1127, 1067, 833cm−1


I-1298
mp 155–158° C.



1H NMR(CDCl3)δ 3.21(s, 3H), 3.45(s, 3H), 3.75(s, 3H), 4.42(s,



4H), 5.93(s, 1H), 6.44(s, 1H), 6.90–6.96(m, 1H), 7.06–7.11(m,



1H), 7.19–7.39(m, 13H), 7.67–7.72(m, 2H)



IR(KBr)3445, 2940, 1615, 1521, 1483, 1367, 1149, 875, 707,



546, 526cm−1


I-1299
mp 174–175° C.



1H NMR(CDCl3)δ 2.15(s, 3H), 3.20(s, 3H), 3.53(s, 3H), 3.78(s,



3H), 4.40(s, 4H), 6.82(s, 1H), 6.91–7.01(m, 2H), 7.11–7.39(m,



13H), 7.65–7.70(m, 2H)



IR(KBr)3028, 2936, 1618, 1520, 1482, 1365, 1176, 1151, 1079,



871, 798, 698, 527cm−1

















TABLE 258







I-1300
mp 218–221° C.



1H NMR(CI)Cl3)δ 2.69(s, 3H), 3.21(s, 3H), 3.55(s, 3H), 3.77(s,



3H), 6.83(s, 1H), 6.86–6.93(m, 1H), 7.02–7.15(m, 2H), 7.35–



7.41(m, 2H), 7.66–7.71(m, 2H)



IR(KBr)3435, 3389, 2940, 1635, 1525, 1362, 1175, 1152, 1076,



962, 874, 802, 527cm−1


I-1301
1H NMR(CDCl3)δ 2.91(s, 3H), 3.22(s, 3H), 3.54(s, 3H), 3.78(s,



3H), 6.86(s, 1H), 7.26–7.33(m, 2H), 7.37–7.42(m, 2H), 7.64–



7.71(m, 2H), 8.15(s, 1H), 8.34–8.41(m, 1H)



IR(KBr)3336, 2943, 1736, 1539, 1480, 1356, 1174, 1151, 1077,



881, 799, 523, 507cm−1


I-1302
powder



1H NMR(CDCl3)δ 1.50(s, 3H), 1.71(s, 3H), 2.78(s, 3H), 3.23(s,



3H), 3.55(s, 3H), 3.78(s, 3H), 4.11–4.20(m, 1H), 4.54–4.63(m,



1H), 5.20–5.28(m, 1H), 6.87(s, 1H), 7.25–7.31(m, 3H),



7.37–7.42(m, 2H), 7.66–7.72(m, 2H)



IR(KBr)2941, 1702, 1482, 1369, 1203, 1176, 1152, 1080, 964,



873, 797, 525cm−1


I-1303
mp 133–136° C.



1H NMR(CDCl3)δ 1.73(s, 3H), 1.77(s, 3H), 3.45(s, 3H), 3.74–



3.78(m, 5H), 4.96(s, 1H), 5.34–5.42(m, 1H), 5.94(s, 1H), 6.45



(s, 1H), 6.75–6.81(m, 1H), 6.89–6.95(m, 2H), 7.10–7.18(m,



2H), 7.51–7.56(m, 2H)



IR(KBr)3401, 2935, 1626, 1614, 1527, 1490, 1402, 1267, 1223,



1113, 1071, 1005, 829, 589cm−1


I-1304
mp 170–171° C.



1HNMR(CDCl3)δ 2.11(s, 3H), 3.47(s, 3H), 4.40(s, 4H), 4.91(s,



1H), 5.81(s, 1H), 6.77(s, 1H), 6.86–7.08(m, 5H), 7.22–7.33(m,



10H), 7.48–7.53(m, 2H)



IR(KBr)3483, 3029, 1612, 1523, 1489, 1453, 1400, 1265, 1215,



834, 749, 698, 494, 526cm−1

















TABLE 259







I-1305
mp 166–168° C.



1H NMR(CDCl3)δ 2.15(s, 3H), 2.17(s, 3H), 3.19(s, 3H), 4.21–



4.59(m, 4H), 6.84–7.05(m, 3H), 7.14–7.15(m, 1H), 7.20–



7.38(m, 12H), 7.63–7.69(m, 2H)



IR(KBr)3028, 2938, 1519, 1476, 1454, 1363, 1174, 1151, 969,



873, 801, 700, 525cm−1


I-1306
mp 210–212° C.



1H NMR(CDCl3)δ 2.11(s, 3H), 2.90(s, 3H), 3.44(s, 3H), 3.52(s,



3H), 6.82–7.02(m, 3H), 7.30(s, 1H), 7.44–7.49(m, 2H), 7.65–



7.71(m, 2H)



IR(KBr)3401, 2850, 1632, 1478, 1365, 1177, 1151, 967, 877,



800, 526cm−1


I-1307
mp 171–173° C.



1H NMR(CDCl3)δ 2.13(s, 3H), 2.95(s, 3H), 3.22(s, 3H), 3.55(s,



3H), 7.17–7.22(m, 3H), 7.35–7.41(m, 2H), 7.64–7.69(m, 2H),



8.17(s, 1H), 8.37.8.43(m, 1H)



IR(KBr)3431, 3034, 2942, 1741, 1538, 1478, 1364, 1291, 1152,



971, 870, 801, 525cm−1


I-1308
powder



1H NMR(CDCl3)δ 1.47(s, 3H), 1.70(s, 3H), 2.11(s, 3H), 2.67–



3.15(m, 3H), 3.22(s, 3H), 3.56(s, 3H), 4.13–4.22(m, 1H), 4.54–



4.63(m, 1H), 5.21–5.28(m, 1H), 7.09–7.42(m, 6H), 7.63–



7.71(m, 2H)



IR(CHCl3)2940, 1700, 1519, 1478, 1372, 1175, 1151,



968cm−1


I-1309
mp 139–141° C.



1H NMR(CDCl3)δ 1.74(s, 3H), 1.78(s, 3H), 2.13(s, 3H), 3.48(s,



3H), 3.77(d, J=6.6Hz, 2H), 4.70–5.20(br s, 1H), 5.25–5.42(m,



1H), 5.77(s, 1H), 6.77–6.83(m, 2H), 6.88–6.99(m, 4H), 7.48–



7.54(m, 2H)



IR(KBr)3525, 3377, 2931, 1625, 1526, 1488, 1222, 1164,



1011, 833cm−1

















TABLE 260







I-1310
mp 177–179° C.



1H NMR (CDCl3)δ 1.76(s, 3H), 1.81(s, 3H), 3.20(t, J=8.4Hz,



2H), 3.21(t, J=8.4Hz, 2H), 4.521(d, J=7.2Hz, 2H), 4.523(t, J=



8.4Hz, 2H), 4.90(brs, 1H), 5.53(t, J=6.8Hz, 1H), 6.71(s, 1H),



6.89(d, J=8.4Hz, 2H), 6.98(d, J=8.7Hz, 2H), 7.41(d, J=8.7Hz,



2H), 7.45(d, J=9.0Hz, 2H)



IR(KBr)3389, 2971, 2911, 1611, 1525, 1394, 1238, 1175, 997,



828cm−1


I-1311
mp 175–177° C.



1H NMR(CDCl3)δ 3.20(t, J=8.3Hz, 4H), 4.53(t, J=8.4Hz,



4H), 4.70(d, J=6.3Hz, 2H), 4.88(brs, 1H), 6.19(t, J=6.2Hz, 1H),



6.89(d, J=8.7Hz, 2H), 6.96(d, J=9.0Hz, 2H), 7.41(d, J=9.0Hz,



2H), 7.47(d, J=8.7Hz, 2H)



IR(KBr)3409, 3269, 2934, 2901, 1524, 1480, 1395, 1235, 1223,



1003, 881, 817cm−1


I-1312
mp 186–187° C.



1H NMR(CDCl3)δ 2.06(s, 3H), 2.16(s, 3H), 4.72(s, 1H), 4.80(d,



J=6.3Hz, 2H), 4.83(s, 1H), 6.25(t, J=6.3Hz, 1H), 6.76(s, 1H),



6.86–6.92(m, 2H), 7.03–7.13(m, 3H), 7.21–7.26(m, 2H)



IR(CHCl3)3689, 3598, 355 1,3024, 3008, 1732, 1614,



1520, 1487, 1260, 1223cm−1


I-1313
mp 201° C.



1H NMR(CDCl3)δ 2.08(s, 3H), 2.17(s, 3H), 3.88(s, 3H), 4.80(d,



J=6.3Hz, 2H), 4.90(br s, 1H), 4.99(s, 1H), 6.26(t, J=6.3Hz,



1H), 6.77(s, 1H), 6.85–6.92(m, 4H), 7.01(d, J=6.9Hz, 1H),



7.22–7.27(m, 2H)



IR(CHCl3)3688, 3598, 3538, 3024, 3014, 2938, 1731,



1631, 1520, 1488, 1240, 1172cm−1


I-1314
mp 132–134° C.



1H NMR(CDCl3)δ 2.12(s, 3H), 2.29(s, 3H), 3.00(s, 6H),



3.74(br, 2H), 6.62(dd, J=2.4, 8.1Hz, 1H), 6.77–6.82(m, 3H),



7.01–7.05(m, 2H), 7.12(s, 1H), 7.26–7.31(m, 2H)



IR(KBr)3600–2800(br), 1610, 1523, 1483, 1443, 1325, 1297



cm−1

















TABLE 261







I-1315
mp 123–125° C.



1H NMR(CDCl3)δ 2.13(s, 3H), 2.29(m, 4H), 3.00(s, 6H),



3.98(br, 3H), 6.63(dd, J=2.4, 8.1Hz, 1H), 6.77–6.81(m, 3H),



7.02(s, 1H), 7.09–7.13(m, 2H), 7.25–7.32(m, 2H)



IR(1(Br)3600–2800(br), 1609, 1525, 1488, 1443, 1356, 1232,



1194cm−1


I-1316
mp 125–127° C.



1H NMR(CDCl3)δ 2.10(s, 3H), 2.31(s, 3H), 3.01(s, 6H),



6.77–6.84(m, 2H), 7.00(s, 1H), 7.15(s, 1H), 7.27–7.33(m, 3H),



7.52(dd, J=3.0, 12.9Hz, 1H), 7.09(d, J=3.0Hz, 1H),



7.95(br s, 1H)



IR(KBr)3600–2800(br), 1707, 1611, 1528, 1484, 1350, 1279,



1229, 1196, 1154cm−1


I-1317
mp 94–95° C.



1H NMR(CDCl3)δ 1.77(s, 3H), 1.81(s, 3H), 2.26(s, 6H),



4.63(d, J=6.6Hz, 2H), 5.51–5.60(m, 1H), 6.01(s, 2H), 6.78–6.89



(m, 3H), 6.97–7.15(m, 5H)


I-1318
1H NMR(CDCl3)δ 1.77(s, 3H), 1.82(s, 3H), 2.29(s, 6H), 4.64(d,



J=6.3Hz, 2H), 5.53–5.60(m, 1H), 6.99–7.21(m, 5H), 7.33–



7.39(m, 2H), 7.49(d.d, J=5.4 & 0.3Hz, 1H), 7.80(s, 1H), 7.92(d,



J=8.1Hz, 1H)


I-1319
mp 188–189° C.



1H NMR(CDCl3)δ 1.31(t, J=7.5Hz, 3H), 2.26(s, 3H), 2.29(s,



3H), 2.68(q, J=7.5Hz, 2H), 5.17(s, 2H), 5.70(brs, 1H), 6.83(d,



J=6.8Hz, 1H), 6.98–7.00(m, 2H), 7.13(d, J=9.0Hz, 2H),



7.26–7.30(m, 2H), 7.38–7.48(m, 5H), 7.78(brs, 1H), 7.86(d,



J=8.7Hz, 1H)



IR(KBr)3444, 3269, 1710, 1533, 1487, 1269, 1244, 1199, 1174,



744, 697cm−1


I-1320
mp 157–159° C.



1H NMR(CDCl3)δ 1.30(t, J=7.6Hz, 3H), 2.27(s, 3H), 2.28(s,



3H), 2.68(q, J=7.2Hz, 2H), 3.91(s, 3H), 5.21(s, 2H), 6.81–



6.97(m, 3H), 7.14(d, J=7.6Hz, 2H), 7.25–7.51(m, 7H), 7.79(brs,



1H), 7.86(d, J=8.8Hz, 1H)



IR(KBr)3434, 3260, 1707, 1519, 1501, 1488, 1260, 1241, 1213,



1172, 744, 697cm−1

















TABLE 262







I-1321
mp 186–187° C.



1H NMR(CDCl3)δ 1.30(t, J=8.4Hz, 3H), 2.26(s, 3H), 2.27(s,



3H), 2.68(q,J=7.5Hz, 2H), 5.20(s, 2H), 7.04–7.14(m, 6H), 7.26–



7.50(m, 6H), 7.79(brs, 1H), 7.86(d, J=8.7Hz, 1H)



IR(KBr)3436, 3266, 1709, 1536, 1521, 1487, 1267, 1199, 1176,



744, 697cm−1


I-1322
mp 136–137° C.



1H NMR(CDCl3)δ 1.32(t, J=7.5Hz, 3H), 2.28(s, 3H), 2.30(s,



3H), 2.70(q, J=7.5Hz, 2H), 3.13(s, 3H), 5.19(s, 2H), 7.12–7.15



(m, 3H), 7.26–7.29(m, 3H), 7.37–7.50(m, 5H), 7.80(brs, 1H),



7.87(d, J=9.0Hz, 1H)



IR(KBr)3435, 1725, 1536, 1486, 1363, 1292, 1266, 1179, 1163,



1108, 7970, 895, 811, 525cm−1


I-1323
mp 150–151° C.



1H NMR(CDCl3)δ 2.18(s, 3H), 2.27(s, 3H), 5.20(s, 2H), 7.04–



7.14(m, 6H), 7.26–7.50(m, 6H), 7.60(d, J=12.0Hz, 1H), 7.94



(brs, 1H)



IR(KBr)3421, 3302, 1712, 1523, 1490, 1422, 1299, 1274, 1205,



1176, 1132, 743, 697cm−1


I-1324
mp 83–84° C.



1H NMR(CDCl3)δ 1.30(t, J=7.6Hz, 3H), 1.77(s, 3H), 1.78(s,



3H), 1.81(s, 6H), 2.31(s, 3H), 2.34(s, 3H), 2.56(q, J=7.6Hz,



2H), 3.80(d, J=6.4Hz, 2H), 3.90(s, 3H), 4.65(d, J=6.2Hz,



2H), 5.44(d, J=6.2Hz, 2H), 5.44(t, J=5.2Hz, 1H), 5.59(t,



J=5.4Hz, 1H), 6.73(d, J=8.0Hz, 1H), 6.92–6.94(m, 3H),



7.12–7.20(m, 4H)



IR(KBr)3428, 3374, 2964, 1607, 1519, 1494, 1458, 1311, 1256,



1239, 1139, 1036, 1002, 855, 820cm−1


I-1325
mp 113–114° C.



1H NMR(CDCl3)δ 1.30(t, J=7.4Hz, 3H), 1.76(s, 3H), 1.78(s,



3H), 1.80(s, 3H), 1.84(s, 3H), 2.30(s, 3H), 2.32(s, 3H), 2.55(q,



J=7.6Hz, 2H), 3.79(d, J=6.6Hz, 2H), 4.63(d, J=6.6Hz, 2H),



5.43(t, J=5.6Hz, 1H), 5.55(t, J=6.6Hz, 1H), 5.73(brs, 1H),



6.72(d, J=8.0Hz, 1H), 6.83–6.98(m, 3H), 7.11–7.19(m, 4H)



IR(KBr)3413, 3298, 2965, 2924, 1518, 1494, 1435, 1242, 1127,



1013, 883cm−1

















TABLE 263







I-1326
mp 81–82° C.



1H NMR(CDCl3)δ 1.29(t, J=7.4Hz, 3H), 1.74(s, 3H), 1.77(s,



3H), 1.78(s, 3H), 1.81(s, 3H), 2.27(s, 3H), 2.31(s, 3H), 2.54(q,



J=7.2Hz, 2H), 3.79(d, J=7.2Hz, 2H), 4.63(d, J=6.6Hz, 2H),



5.42(t, J=6.4Hz, 1H), 5.55(t, J=6.6Hz, 1H), 6.71(d, J=8.0Hz,



1H), 7.04–7.19(m, 7H)



IR(KBr)3413, 2969, 2912, 2856, 1613, 1520, 1492, 1295, 1261,



1127, 1004, 881, 813cm−1


I-1327
mp 94–95° C.



1H NMR(CDCl3)δ 1.74(s, 3H), 1.77(s, 6H), 1.81(s, 3H), 2.21(s,



3H), 2.26(s, 3H), 3.72(d, J=6.9Hz, 2H), 4.63(d, J=6.3Hz, 2H),



5.35(t, J=6.9Hz, 1H), 5.55(t, J=6.9Hz, 1H), 6.37–6.48(m,



2H), 7.01–7.13(m, 6H)



IR(KBr)3423, 2967, 2918, 1627, 1525, 1488, 1296, 1267, 1129,



981, 837, 805cm−1


I-1328
mp 178–180° C. (decomp.)



1H NMR(DMSO-d6)δ 3.30(s, 3H), 3.64(s, 3H), 4.45(s, 2H),



5.65(s, 2H), 6.39(s, 1H), 6.65(dd, J=8.4, 2.1Hz, 1H), 6.74(d, J=



2.1Hz, 1H), 6.84(d, J=8.7Hz, 2H), 6.99(d, J=8.4Hz, 1H),



7.43(d, J=8.7Hz, 2H), 9.26(s, 1H)



IR(Nujol)3487, 3382, 1696, 1670, 1591, 1523, 1491, 1458,



1243, 1202, 1114, 1077, 1013, 937, 811cm−1


I-1329
mp 205–210° C. (decomp.)



1H NMR(DMSO-d6)δ 3.34(s, 3H), 3.44(s, 3H), 3.67(s, 3H),



4.93(s, 2H), 6.43(s, 1H), 6.76(dd, J=8.4, 2.1Hz, 1H), 6.85(d, J=



2.1Hz, 1H), 6.86(d, J=8.7Hz, 2H), 7.04(d, J=8.4Hz, 1H),



7.46(d, J=8.7Hz, 2H)



IR(Nujol)3388, 3333, 3270, 1671, 1614, 1579, 1556, 1523,



1443, 1223, 1172, 1121, 1033, 922, 813cm−1


I-1330
mp 185–187° C.



1H NMR(CDCl3)δ 1.79(t, J=2.6Hz, 3H), 2.69(m, 2H), 2.75(s,



3H), 3.21(s, 3H), 3.29(s, 3H), 3.56(s, 3H), 3.77(s, 3H), 4.17(t,



J=6.6Hz, 2H), 6.84(s, 1H), 7.08(d, J=9.0Hz, 1H), 7.36(dd, J=



9.0, 2.1Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.40(d, J=2.1Hz, 1H),



7.68(d, J=8.7Hz, 2H)



IR(Nujol)1604, 1520, 1480, 1175, 1151, 1081, 1012, 971, 948,



878, 840, 807cm−1

















TABLE 264







I-1331
foam



1H NMR(CDCl3)δ 1.81(t, J=2.4Hz, 3H), 2.65(m, 2H), 3.45(s,



3H), 3.74(s, 3H), 4.16(t, J=6.6Hz, 2H), 6.45(s, 1H), 6.92(d,



J=8.7Hz, 2H), 6.95(m, 2H), 7.07(brs, 1H), 7.07(d, J=8.7Hz, 2H)



IR(Nujol)3427, 1612, 1586, 1523, 1489, 1251, 1224, 1113,



1071, 1012cm−1


I-1332
foam



1H NMR(CDCl3)δ 3.45(s, 3H), 3.75(s, 3H), 4.16(m, 2H),



4.76(m, 2H), 5.89~6.02(m, 2H), 6.45(s, 1H), 6.92(d, J=8.7Hz,



2H), 6.96(m, 2H), 7.09(brs, 1H), 7.53(d, J=8.7Hz, 2H)



IR(Nujol)3433, 1612, 1588, 1523, 1489, 1286, 1248, 1224,



1175, 1113, 1070, 1011cm−1


I-1333
foam



1H NMR(CDCl3)δ 3.45(s, 3H), 3.74(s, 3H), 4.11(m, 2H),



4.67(m, 2H), 5.96~6.12(m, 2H), 6.45(s, 1H), 6.92(d, J=8.7Hz,



2H), 6.92(d, J=8.4Hz, 1H), 6.96(dd, J=8.4, 2.1Hz, 1H), 7.08(d,



J=2.1Hz, 1H), 7.53(d, J=8.7Hz, 2H)



IR(Nujol)3434, 1612, 1588, 1523, 1489, 1285, 1248, 1224,



1174, 1112, 1070, 1011cm−1


I-1334
foam



1H NMR(CDCl3)δ 1.95(s, 3H), 3.45(s, 3H), 3.75(s, 3H),



4.11(s, 2H), 4.68(d, J=6.9Hz, 2H), 5.75(d, J=6.9Hz, 1H), 6.45(s,



1H), 6.91(d, J8.7Hz, 2H), 6.96(s, 2H), 7.08(s, 1H), 7.53(d, J=



8.7Hz, 2H)



IR(KBr)3390, 1612, 1585, 1523, 1491, 1225, 1072, 1003, 822



cm−1


I-1335
m.p 179–180° C.



1H NMR(CDCl3)δ 1.88(s, 3H), 3.45(s, 3H), 3.75(s, 3H),



4.07(s, 2H), 4.69(d, J=6.6Hz, 2H), 5.89(d, J=6.6Hz, 1H), 6.45(s,



1H), 6.91(d, J=8.7Hz, 2H), 6.92(d, J=8.4Hz, 1H), 6.96(dd, J=



1.8, 8.4Hz, 1H), 7.07(d, J=1.8Hz, 1H), 7.53(d, J=8.7Hz, 2H)



IR(KBr)3392, 1609, 1584, 1523, 1492, 1226, 1116, 1072, 1002,



813, 782cm−1

















TABLE 265







I-136
foam



1H NMR(CD3OD)δ 3.38(s, 3H), 3.67(s, 3H), 3.88(dd, J=7.8,



9.9Hz, 1H), 4.10(dd, J=3.6, 9.9Hz, 1H), 4.51(m, 1H), 5.25(dt,



J=10.5, 1.5Hz, 1H), 5.44(dt, J=17.4, 1.5Hz, 1H), 6.00(ddd,



J=5.4, 10.5, 17.4Hz, 1H), 6.43(s, 1H), 6.79(dd, J=1.8, 8.4Hz,



1H), 6.85(d, J=8.7Hz, 2H), 6.86(d, J=1.8Hz, 1H), 6.92(d,



J=8.4Hz, 1H), 7.45(d, J=8.7Hz, 2H)



IR(KBr)3399, 2934, 1612, 1588, 1523, 1489, 1254, 1114, 1071,



1012, 939, 816cm−1


I-1337
foam



1H NMR(CDCl3)δ 3.45(s, 3H), 3.75(s, 3H), 4.20(t, J=2.1Hz,



2H), 4.84(t, J=2.1Hz, 2H), 6.45(s, 1H), 6.92(d, J=8.7Hz, 2H),



6.98(dd, J=2.1, 8.4Hz, 1H), 7.04(d, J=8.4Hz, 1H), 7.09(d,



J=2.1Hz, 1H), 7.45(d, J=8.7Hz, 2H)



IR(KBr)3431, 1612, 1589, 1523, 1489, 1404, 1224, 1113, 1070,



1011, 939, 826cm−1


I-1338
foam



1H NMR(CD3OD)δ 3.38(s, 3H), 3.67(s, 3H), 4.25(d, J=21.0Hz,



2H), 4.84(s, J=7.5Hz, 2H), 5.58(dt, J=19.5, 7.5Hz, 1H),



6.43(s, 1H), 6.79(dd, J=2.1, 8.4Hz, 1H), 6.84(d, J=8.7Hz,



2H), 6.86(d, J=2.1Hz, 1H), 6.96(d, J=8.4Hz, 1H), 7.45(d,



J=8.7Hz, 2H)



IR(KBr)3409, 1701, 1612, 1591, 1523, 1489, 1404, 1246, 1113,



1071, 1010, 939, 816cm−1


I-1339
foam



1H NMR(CDCl3)δ 3.44(s, 3H), 3.74(s, 3H), 4.21(d, J=21.3Hz,



2H), 4.66(dd, J=1.8, 7.5Hz, 2H), 5.70(dt, J=16.5, 7.5Hz, 1H),



6.45(s, 1H), 6.95(d, J=8.7Hz, 2H), 6.96(d, J=8.4Hz, 1H),



6.98(dd, J=1.5, 8.4Hz, 1H), 7.09(d, J=1.5Hz, 1H), 7.51(d,



J=8.7Hz, 2H)



IR(KBr)3411, 1698, 1611, 1588, 1522, 1488, 1223, 1112, 1070,



1011, 939, 825cm−1


I-1340
mp 171–172° C.



1H NMR(CDCl3)δ 1.50(s, 3H), 1.67(s, 3H), 1.96(s, 3H), 3.45(s,



3H), 3.77(s, 3H), 4.13–4.49(m, 2H), 5.23–5.30(m, 1H), 5.59(s,



1H), 6.13(s, 1H), 6.47(s, 1H), 6.92–6.98(m, 2H), 7.18–7.35(m,



3H), 7.50–7.57(m, 2H)



IR(KBr)3390, 3140, 2935, 1640, 1523, 1401, 1240, 1119, 1070,



835, 820cm−1

















TABLE 266







I-1341
mp 216–218° C.



1H NMR(CDCl3+CD3OD)δ 1.46(s, 3H), 1.67(s, 3H), 1.95(s,



3H), 2.10(s, 3H), 3.46(s, 3H), 4.16–4.47(m, 2H), 5.21–5.28(m,



1H), 6.79(s, 1H), 6.88–6.95(m, 2H), 7.11–7.27(m, 3H),



7.45–7.52(m, 2H)



IR(KBr)3337, 3099, 2928, 1637, 1608, 1587, 1521, 1444, 1409,



1261, 1232, 1161, 836, 769, 592, 540cm−1


I-1342
mp 103–105° C.



1H NMR(CDCl3)δ 1.15(d, J=6.8Hz, 6H), 2.26(s, 3H), 3.08(sept,



J=6.8Hz, 1H), 4.94(s, 1H), 5.20(s, 2H), 6.88(d, J=8.7Hz, 2H),



7.04–7.07(m, 3H), 7.12–7.18(m, 1H), 7.18(s, 1H), 7.20(d,



J=8.7Hz, 2H), 7.32–7.51(m, 5H)



IR(KBr)3429, 1522, 1490, 1262, 1227, 1128, 1011, 833cm−1


I-1343
mp 115–117° C.



1HNMR(CDCl3)δ 1.15(d, J=6.6Hz, 6H), 1.77(s, 3H), 1.82(s,



3H), 2.27(s, 3H), 3.08(sept, J=6.8Hz, 1H), 4.64(d, J=6.9Hz,



2H), 4.86(s, 1H), 5.56(t, J=6.9Hz, 1H), 6.89(d, J=8.6Hz, 2H),



7.03(t, J=8.4Hz, 1H), 7.05–7.19(m, 3H), 7.19(s, 1H), 7.21(d,



J=8.6Hz, 2H)



IR(KBr)3524, 1611, 1523, 1489, 1260, 1228, 1200, 1128,



836cm−1


I-1344
mp 119–120° C.



1H NMR(CDCl3)δ 1.15(d, J=6.9Hz, 6H), 2.26(s, 3H), 3.08(sept,



J=6.8Hz, 1H), 4.79(d, J=6.3Hz, 2H), 4.85(s, 1H), 6.25(t, J=



6.3Hz, 1H), 6.89(d, J=8.7Hz, 2H), 7.01(t, J=8.4Hz, 1H),



7.07–7.12(m, 2H), 7.15(dd, J=12.0, 2.1Hz, 1H), 7.18(s, 1H),



7.20(d, J=8.7Hz, 2H)



IR(KBr)3425, 1610, 1523, 1488, 1300, 1263, 1300, 1263,



1227, 1134, 1038, 896cm−1


I-1345
mp 109–110° C.



1H NMR(CDCl3)δ 1.34(d, J=6.9Hz, 3H), 2.24(s, 3H), 4.00(q,



J=6.9Hz, 2H), 4.77–4.79(m, 3H), 6.24(t, J=6.3Hz, 1H),



6.86–6.90(m, 2H), 6.98–7.19(m, 4H), 7.47–7.50(m, 2H)



IR(CHCl3)3596, 2927, 1612, 1523, 1493, 1476,



1388, 1299, 1259, 1173, 1127, 1049, 885, 834cm−1

















TABLE 267







I-1346
mp 114–116° C.



1H NMR(CDCl3)δ 1.33(d, J6.9Hz, 3H), 1.77(s, 3H), 1.81(s,



3H), 2.24(s, 3H), 4.00(q, J=6.9Hz, 2H), 4.63(m, 2H), 4.73(br,



1H), 5.56(m, 1H), 6.81(s, 1H), 6.86–6.90(m, 2H), 7.00–7.19(m,



4H), 7.47–4.51(m, 2H)



IR(CHCl3)3596, 2929, 2877, 1610, 1523, 1493, 1476, 1386,



1329, 1316, 1297, 1261, 1173, 1125, 1048, 992, 834cm−1


I-1347
mp 144–146° C.



1H NMR(CDCl3)δ 3.20(s, 3H), 3.40(s, 3H), 3.75(s, 3H), 4.74(s,



2H), 5.19(s, 2H), 6.44(s, 1H), 7.05–7.62(m, 12H)



IR(KBr)3437, 1614, 1579, 1.520, 1488, 1465, 1453, 1436,



1414, 1393, 1129, 1114, 1085, 1063cm−1


I-1348
mp 156–159° C.



1H NMR(CDCl3)δ 2.48(s, 3H), 3.05(s, 3H), 3.20(s, 3H), 3.78(s,



3H), 4.83(s, 2H), 5.21(s, 2H), 6.84(s, 1H), 7.02–7.67(m, 12H)



IR(KBr)3430, 2940, 1607, 1522, 1481, 1452, 1419, 1389,



1365, 1294, 1273, 1230, 1200, 1176, 1151, 1132, 1080,



1011cm−1


I-1349
mp 155–156° C.



1H NMR(CDCl3)δ 1.15(t, J=6.9Hz, 3H), 3.60(q, J=6.9Hz,



2H), 3.75(s, 3H), 3.90(s, 3H), 4.93(bs, 1H), 5.20(s, 2H), 5.98(s,



1H), 6.46(s, 1H), 6.90–7.05(m, 5H), 7.26–7.56(m, 7H)



IR(KBr)3409, 2938, 1613, 1522, 1438, 1416, 1396, 1382,



1360, 1268, 1232, 1211, 1169, 1131, 1113, 1078, 1022,



1006cm−


I-1350
mp 58–60° C.



1H NMR(DMSO-d6)δ 1.71(s, 6H), 2.21(s, 3H), 2.22(s, 3H),



3.71–3.75(m, 2H), 5.11(br s, 2H), 5.25–5.29(m, 1H), 5.50–



5.53(m, 1H), 6.60–6.63(m, 2H), 6.66–6.73(m, 1H), 6.95–



7.05(m, 6H)



IR(KBr)3600–2800(br), 1623, 1527, 1492, 1454, 1428,



1331, 1269, 1257, 1184, 1116cm−1

















TABLE 268







I-1351
mp 140–142° C. (dec.)



1H NMR(CDCl3)δ 2.33(s, 3H), 4.93(s, 1H), 5.19(s, 2H),



6.89(d, J=8.7Hz, 2H), 7.06(t, J=8.6Hz, 1H), 7.23(d, J=8.7Hz,



2H), 7.24–7.50(m, 10H)



IR(KBr)3400, 1609, 1529, 1490, 1269, 1243, 1005, 807,



745cm−1


I-1352
mp 114–116° C.



1H NMR(CDCl3)δ 1.77(s, 3H), 1.81(s, 3H), 2.33(s, 3H),



4.63(d, J=6.9Hz, 2H), 4.89(s, 1H), 5.54(t, J=6.9Hz, 1H), 6.89(d,



J=8.6Hz, 2H), 7.04(t, J=8.6Hz, 1H), 7.23(d, J=8.6Hz, 2H),



7.25–7.43(m, 5H)



IR(KBr)3368, 1609, 1526, 1490, 1271, 1241, 1131, 991, 827,



811cm−1


I-1353
mp 78–79° C.



1H NMR(CDCl3)δ 1.77(s, 3H), 1.82(s, 3H), 2.24(s, 3H),



2.27(s, 3H), 4.64(d, J=6.6Hz, 2H), 5.51–5.59(m, 1H), 6.98–



7.20(m, 7H), 7.28–7.36(m, 2H)


















TABLE 269









(I)













 






















No.
R1
R2
R3
R4
R5
R6
R7
R8
R9
R10
R11
R12
R13
X
Y





I-1354
OH
H
H
H
H
H
OMe
OMe
OH
H
H
H
OMs
O
—CH2CH═CMe2


I-1355
OH
H
H
H
H
H
OMe
OMe
OH
H
H
H
OMs
O
—(CH2)2CH═CMe2


I-1356
OH
H
H
H
H
H
OMe
OMe
OH
H
H
H
OMs
O
—CH2CH═CCl2


I-1357
OH
H
H
H
H
H
OMe
OMe
OH
H
H
H
OMs
O
—CH2C≡CMe


I-1358
OH
H
H
H
H
H
OMe
OMe
OH
H
H
H
OMs
O
—CH2C6H4-4-Me


I-1359
OH
H
H
H
H
H
OMe
OMe
OH
H
H
H
COOH
O
—(CH2)2CH═CMe2


I-1360
OH
H
H
H
H
H
OMe
OMe
OH
H
H
H
COOH
O
—CH2CH═CCl2


I-1361
OH
H
H
H
H
H
OMe
OMe
OH
H
H
H
COOH
O
—CH2C≡CMe


I-1362
OH
H
H
H
H
H
OMe
OMe
OH
H
H
H
COOH
O
—CH2C6H4-4-Me


I-1363
OH
H
H
H
H
H
OMe
OMe
OH
H
H
H
CH2OH
O
—(CH2)2CH═CMe2


I-1364
OH
H
H
H
H
H
OMe
OMe
OH
H
H
H
CH2OH
O
—CH2CH═CCl2


I-1365
OH
H
H
H
H
H
OMe
OMe
OH
H
H
H
CH2OH
O
—CH2C≡CMe


I-1366
OH
H
H
H
H
H
OMe
OMe
OH
H
H
H
CH2OH
O
—CH2C6H4-4-Me


I-1367
OH
H
H
H
H
H
OMe
OMe
OH
H
H
H
F
O
—(CH2)2CH═CMe2


I-1368
OH
H
H
H
H
H
OMe
OMe
OH
H
H
H
F
O
—CH2CH═CCl2


I-1369
OH
H
H
H
H
H
OMe
OMe
OH
H
H
H
F
O
—CH2C≡CMe































TABLE 270







I-1370
OH
H
H
H
H
H
OMe
OMe
OH
H
H
H
F
O
—CH2C6H4-4-Me


I-1371
OH
H
H
H
H
H
OMe
OMe
COOH
H
H
H
OH
O
—CH2CH═CCl2


I-1372
OH
H
H
H
H
H
OMe
OMe
COOH
H
H
H
OH
O
—CH2C≡CMe


I-1373
OH
H
H
H
H
H
OMe
OMe
COOH
H
H
H
OMs
O
—CH2CH═CMe2


I-1374
OH
H
H
H
H
H
OMe
OMe
COOH
H
H
H
OMs
O
—(CH2)2CH═CMe2


I-1375
OH
H
H
H
H
H
OMe
OMe
COOH
H
H
H
OMs
O
—CH2CH═CCl2


I-1376
OH
H
H
H
H
H
OMe
OMe
COOH
H
H
H
OMs
O
—CH2C≡CMe


I-1377
OH
H
H
H
H
H
OMe
OMe
COOH
H
H
H
OMs
O
—CH2C6H4-4-Me


I-1378
OH
H
H
H
H
H
OMe
OMe
COOH
H
H
H
COOH
O
—CH2CH═CMe2


I-1379
OH
H
H
H
H
H
OMe
OMe
COOH
H
H
H
COOH
O
—(CH2)2CH═CMe2


I-1380
OH
H
H
H
H
H
OMe
OMe
COOH
H
H
H
COOH
O
—CH2CH═CCl2


I-1381
OH
H
H
H
H
H
OMe
OMe
COOH
H
H
H
COOH
O
—CH2C≡CMe


I-1382
OH
H
H
H
H
H
OMe
OMe
COOH
H
H
H
COOH
O
—CH2C6H4-4-Me


I-1383
OH
H
H
H
H
H
OMe
OMe
COOH
H
H
H
CH2OH
O
—CH2CH═CMe2


I-1384
OH
H
H
H
H
H
OMe
OMe
COOH
H
H
H
CH2OH
O
—(CH2)2CH═CMe2


I-1385
OH
H
H
H
H
H
OMe
OMe
COOH
H
H
H
CH2OH
O
—CH2CH═CCl2


I-1386
OH
H
H
H
H
H
OMe
OMe
COOH
H
H
H
CH2OH
O
—CH2C≡CMe


I-1387
OH
H
H
H
H
H
OMe
OMe
COOH
H
H
H
CH2OH
O
—CH2C6H4-4-Me


I-1388
OH
H
H
H
H
H
OMe
OMe
COOH
H
H
H
F
O
—CH2CH═CCl2


I-1389
OH
H
H
H
H
H
OMe
OMe
COOH
H
H
H
F
O
—CH2C≡CMe


I-1390
OH
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
OH
O
—CH2CH═CMe2































TABLE 271







I-1391
OH
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
OH
O
—(CH2)2CH═CMe2


I-1392
OH
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
OH
O
—CH2CH═CCl2


I-1393
OH
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
OH
O
—CH2C≡CMe


I-1394
OH
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
OH
O
—CH2C6H4-4-Me


I-1395
OH
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
OMs
O
—CH2CH═CMe2


I-1396
OH
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
OMs
O
—(CH2)2CH═CMe2


I-1397
OH
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
OMs
O
—CH2CH═CCl2


I-1398
OH
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
OMs
O
—CH2C≡CMe


I-1399
OH
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
OMs
O
—CH2C6H4-4-Me


I-1400
OH
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
COOH
O
—CH2CH═CMe2


I-1401
OH
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
COOH
O
—(CH2)2CH═CMe2


I-1402
OH
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
COOH
O
—CH2CH═CCl2


I-1403
OH
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
COOH
O
—CH2C≡CMe


I-1404
OH
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
COOH
O
—CH2C6H4-4-Me


I-1405
OH
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
CH2OH
O
—CH2CH═CMe2


I-1406
OH
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
CH2OH
O
—CH2CH═CCl2


I-1407
OH
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
CH2OH
O
—CH2C≡CMe


I-1408
OH
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
CH2OH
O
—CH2C6H4-4-Me


I-1409
OH
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
F
O
—CH2CH═CMe2


I-1410
OH
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
F
O
—(CH2)2CH═CMe2


I-1411
OH
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
F
O
—CH2CH═CCl2































TABLE 272







I-1412
OH
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
F
O
—CH2C≡CMe


I-1413
OH
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
F
O
—CH2C6H4-4-Me


I-1414
OH
H
H
H
H
H
OMe
OMe
Me
H
H
H
OH
O
—CH2CH═CCl2


I-1415
OH
H
H
H
H
H
OMe
OMe
Me
H
H
H
OH
O
—CH2C≡CMe


I-1416
OH
H
H
H
H
H
OMe
OMe
Me
H
H
H
OMs
O
—CH2CH═CMe2


I-1417
OH
H
H
H
H
H
OMe
OMe
Me
H
H
H
OMs
O
—(CH2)2CH═CMe2


I-1418
OH
H
H
H
H
H
OMe
OMe
Me
H
H
H
OMs
O
—CH2CH═CCl2


I-1419
OH
H
H
H
H
H
OMe
OMe
Me
H
H
H
OMs
O
—CH2C≡CMe


I-1420
OH
H
H
H
H
H
OMe
OMe
Me
H
H
H
OMs
O
—CH2C6H4-4-Me


I-1421
OH
H
H
H
H
H
OMe
OMe
Me
H
H
H
COOH
O
—CH2CH═CMe2


I-1422
OH
H
H
H
H
H
OMe
OMe
Me
H
H
H
COOH
O
—(CH2)2CH═CMe2


I-1423
OH
H
H
H
H
H
OMe
OMe
Me
H
H
H
COOH
O
—CH2CH═CCl2


I-1424
OH
H
H
H
H
H
OMe
OMe
Me
H
H
H
COOH
O
—CH2C≡CMe


I-1425
OH
H
H
H
H
H
OMe
OMe
Me
H
H
H
COOH
O
—CH2C6H4-4-Me


I-1426
OH
H
H
H
H
H
OMe
OMe
Me
H
H
H
CH2OH
O
—CH2CH═CMe2


I-1427
OH
H
H
H
H
H
OMe
OMe
Me
H
H
H
CH2OH
O
—(CH2)2CH═CMe2


I-1428
OH
H
H
H
H
H
OMe
OMe
Me
H
H
H
CH2OH
O
—CH2CH═CCl2


I-1429
OH
H
H
H
H
H
OMe
OMe
Me
H
H
H
CH2OH
O
—CH2C≡CMe


I-1430
OH
H
H
H
H
H
OMe
OMe
Me
H
H
H
CH2OH
O
—CH2C6H4-4-Me


I-1431
OH
H
H
H
H
H
OMe
OMe
Me
H
H
H
F
O
—CH2CH═CMe2


I-1432
OH
H
H
H
H
H
OMe
OMe
Me
H
H
H
F
O
—(CH2)2CH═CMe2































TABLE 273







I-1433
OH
H
H
H
H
H
OMe
OMe
Me
H
H
H
F
O
—CH2CH═CCl2


I-1434
OH
H
H
H
H
H
OMe
OMe
Me
H
H
H
F
O
—CH2C≡CMe


I-1435
OH
H
H
H
H
H
OMe
OMe
Me
H
H
H
F
O
—CH2C6H4-4-Me


I-1436
OH
H
H
H
H
H
OMe
OMe
H
H
H
H
OH
O
—CH2CH═CCl2


I-1437
OH
H
H
H
H
H
OMe
OMe
H
H
H
H
OH
O
—CH2C≡CMe


I-1438
OH
H
H
H
H
H
OMe
OMe
H
H
H
H
OH
O
—CH2C6H4-4-Me


I-1439
OH
H
H
H
H
H
OMe
OMe
H
H
H
H
OMs
O
—(CH2)2CH═CMe2


I-1440
OH
H
H
H
H
H
OMe
OMe
H
H
H
H
OMs
O
—CH2CH═CCl2


I-1441
OH
H
H
H
H
H
OMe
OMe
H
H
H
H
OMs
O
—CH2C≡CMe


I-1442
OH
H
H
H
H
H
OMe
OMe
H
H
H
H
OMs
O
—CH2C6H4-4-Me


I-1443
OH
H
H
H
H
H
OMe
OMe
H
H
H
H
COOH
O
—CH2CH═CMe2


I-1444
OH
H
H
H
H
H
OMe
OMe
H
H
H
H
COOH
O
—(CH2)2CH═CMe2


I-1445
OH
H
H
H
H
H
OMe
OMe
H
H
H
H
COOH
O
—CH2CH═CCl2


I-1446
OH
H
H
H
H
H
OMe
OMe
H
H
H
H
COOH
O
—CH2C≡CMe


I-1447
OH
H
H
H
H
H
OMe
OMe
H
H
H
H
COOH
O
—CH2C6H4-4-Me


I-1448
OH
H
H
H
H
H
OMe
OMe
H
H
H
H
CH2OH
O
—CH2CH═CMe2


I-1449
OH
H
H
H
H
H
OMe
OMe
H
H
H
H
CH2OH
O
—(CH2)2CH═CMe2


I-1450
OH
H
H
H
H
H
OMe
OMe
H
H
H
H
CH2OH
O
—CH2CH═CCl2


I-1451
OH
H
H
H
H
H
OMe
OMe
H
H
H
H
CH2OH
O
—CH2C≡CMe


I-1452
OH
H
H
H
H
H
OMe
OMe
H
H
H
H
CH2OH
O
—CH2C6H4-4-Me


I-1453
OH
H
H
H
H
H
OMe
OMe
H
H
H
H
F
O
—(CH2)2CH═CMe2































TABLE 274







I-1454
OH
H
H
H
H
H
OMe
OMe
H
H
H
H
F
O
—CH2CH═CCl2


I-1455
OH
H
H
H
H
H
OMe
OMe
H
H
H
H
F
O
—CH2C≡CMe


I-1456
OH
H
H
H
H
H
OMe
OMe
H
H
H
H
F
O
—CH2C6H4-4-Me


I-1457
OH
H
H
H
H
F
OMe
OMe
OH
H
H
H
OH
O
—(CH2)2CH═CMe2


I-1458
OH
H
H
H
H
F
OMe
OMe
OH
H
H
H
OH
O
—CH2CH═CCl2


I-1459
OH
H
H
H
H
F
OMe
OMe
OH
H
H
H
OH
O
—CH2C≡CMe


I-1460
OH
H
H
H
H
F
OMe
OMe
OH
H
H
H
OH
O
—CH2C6H4-4-Me


I-1461
OH
H
H
H
H
F
OMe
OMe
OH
H
H
H
OMs
O
—CH2CH═CMe2


I-1462
OH
H
H
H
H
F
OMe
OMe
OH
H
H
H
OMs
O
—(CH2)2CH═CMe2


I-1463
OH
H
H
H
H
F
OMe
OMe
OH
H
H
H
OMs
O
—CH2CH═CCl2


I-1464
OH
H
H
H
H
F
OMe
OMe
OH
H
H
H
OMs
O
—CH2C≡CMe


I-1465
OH
H
H
H
H
F
OMe
OMe
OH
H
H
H
OMs
O
—CH2C6H4-4-Me


I-1466
OH
H
H
H
H
F
OMe
OMe
OH
H
H
H
COOH
O
—CH2CH═CMe2


I-1467
OH
H
H
H
H
F
OMe
OMe
OH
H
H
H
COOH
O
—(CH2)2CH═CMe2


I-1468
OH
H
H
H
H
F
OMe
OMe
OH
H
H
H
COOH
O
—CH2CH═CCl2


I-1469
OH
H
H
H
H
F
OMe
OMe
OH
H
H
H
COOH
O
—CH2C≡CMe


I-1470
OH
H
H
H
H
F
OMe
OMe
OH
H
H
H
COOH
O
—CH2C6H4-4-Me


I-1471
OH
H
H
H
H
F
OMe
OMe
OH
H
H
H
CH2OH
O
—CH2CH═CMe2


I-1472
OH
H
H
H
H
F
OMe
OMe
OH
H
H
H
CH2OH
O
—(CH2)2CH═CMe2


I-1473
OH
H
H
H
H
F
OMe
OMe
OH
H
H
H
CH2OH
O
—CH2CH═CCl2


I-1474
OH
H
H
H
H
F
OMe
OMe
OH
H
H
H
CH2OH
O
—CH2C≡CMe































TABLE 275







I-1475
OH
H
H
H
H
F
OMe
OMe
OH
H
H
H
CH2OH
O
—CH2C6H4-4-Me


I-1476
OH
H
H
H
H
F
OMe
OMe
OH
H
H
H
F
O
—CH2CH═CMe2


I-1477
OH
H
H
H
H
F
OMe
OMe
OH
H
H
H
F
O
—(CH2)2CH═CMe2


I-1478
OH
H
H
H
H
F
OMe
OMe
OH
H
H
H
F
O
—CH2CH═CCl2


I-1479
OH
H
H
H
H
F
OMe
OMe
OH
H
H
H
F
O
—CH2C≡CMe


I-1480
OH
H
H
H
H
F
OMe
OMe
OH
H
H
H
F
O
—CH2C6H4-4-Me


I-1481
OMs
H
H
H
H
H
OMe
OMe
OH
H
H
H
OH
O
—CH2CH═CMe2


I-1482
OMs
H
H
H
H
H
OMe
OMe
OH
H
H
H
OH
O
—(CH2)2CH═CMe2


I-1483
OMs
H
H
H
H
H
OMe
OMe
OH
H
H
H
OH
O
—CH2CH═CCl2


I-1484
OMs
H
H
H
H
H
OMe
OMe
OH
H
H
H
OH
O
—CH2C≡CMe


I-1485
OMs
H
H
H
H
H
OMe
OMe
OH
H
H
H
OH
O
—CH2C6H4-4-Me


I-1486
OMs
H
H
H
H
H
OMe
OMe
OH
H
H
H
OMs
O
—CH2CH═CMe2


I-1487
OMs
H
H
H
H
H
OMe
OMe
OH
H
H
H
OMs
O
—(CH2)2CH═CMe2


I-1488
OMs
H
H
H
H
H
OMe
OMe
OH
H
H
H
OMs
O
—CH2CH═CCl2


I-1489
OMs
H
H
H
H
H
OMe
OMe
OH
H
H
H
OMs
O
—CH2C≡CMe


I-1490
OMs
H
H
H
H
H
OMe
OMe
OH
H
H
H
OMs
O
—CH2C6H4-4-Me


I-1491
OMs
H
H
H
H
H
OMe
OMe
OH
H
H
H
COOH
O
—CH2CH═CMe2


I-1492
OMs
H
H
H
H
H
OMe
OMe
OH
H
H
H
COOH
O
—(CH2)2CH═CMe2


I-1493
OMs
H
H
H
H
H
OMe
OMe
OH
H
H
H
COOH
O
—CH2CH═CCl2


I-1494
OMs
H
H
H
H
H
OMe
OMe
OH
H
H
H
COOH
O
—CH2C≡CMe


I-1495
OMs
H
H
H
H
H
OMe
OMe
OH
H
H
H
COOH
O
—CH2C6H4-4-Me































TABLE 276







I-1496
OMs
H
H
H
H
H
OMe
OMe
OH
H
H
H
CH2OH
O
—CH2CH═CMe2


I-1497
OMs
H
H
H
H
H
OMe
OMe
OH
H
H
H
CH2OH
O
—(CH2)2CH═CMe2


I-1498
OMs
H
H
H
H
H
OMe
OMe
OH
H
H
H
CH2OH
O
—CH2CH═CCl2


I-1499
OMs
H
H
H
H
H
OMe
OMe
OH
H
H
H
CH2OH
O
—CH2C≡CMe


I-1500
OMs
H
H
H
H
H
OMe
OMe
OH
H
H
H
CH2OH
O
—CH2C6H4-4-Me


I-1501
OMs
H
H
H
H
H
OMe
OMe
OH
H
H
H
F
O
—CH2CH═CMe2


I-1502
OMs
H
H
H
H
H
OMe
OMe
OH
H
H
H
F
O
—(CH2)2CH═CMe2


I-1503
OMs
H
H
H
H
H
OMe
OMe
OH
H
H
H
F
O
—CH2CH═CCl2


I-154 
OMs
H
H
H
H
H
OMe
OMe
OH
H
H
H
F
O
—CH2C≡CMe


I-1505
OMs
H
H
H
H
H
OMe
OMe
OH
H
H
H
F
O
—CH2C6H4-4-Me


I-1506
OMs
H
H
H
H
H
OMe
OMe
COOH
H
H
H
OH
O
—CH2CH═CMe2


I-1507
OMs
H
H
H
H
H
OMe
OMe
COOH
H
H
H
OH
O
—(CH2)2CH═CMe2


I-1508
OMs
H
H
H
H
H
OMe
OMe
COOH
H
H
H
OH
O
—CH2CH═CCl2


I-1509
OMs
H
H
H
H
H
OMe
OMe
COOH
H
H
H
OH
O
—CH2C≡CMe


I-1510
OMs
H
H
H
H
H
OMe
OMe
COOH
H
H
H
OH
O
—CH2C6H4-4-Me


I-1511
OMs
H
H
H
H
H
OMe
OMe
COOH
H
H
H
OMs
O
—CH2CH═CMe2


I-1512
OMs
H
H
H
H
H
OMe
OMe
COOH
H
H
H
OMs
O
—(CH2)2CH═CMe2


I-1513
OMs
H
H
H
H
H
OMe
OMe
COOH
H
H
H
OMs
O
—CH2CH═CCl2


I-1514
OMs
H
H
H
H
H
OMe
OMe
COOH
H
H
H
OMs
O
—CH2C≡CMe


I-1515
OMs
H
H
H
H
H
OMe
OMe
COOH
H
H
H
OMs
O
—CH2C6H4-4-Me


I-1516
OMs
H
H
H
H
H
OMe
OMe
COOH
H
H
H
COOH
O
—CH2CH═CMe2































TABLE 277







I-1517
OMs
H
H
H
H
H
OMe
OMe
COOH
H
H
H
COOH
O
—(CH2)2CH═CMe2


I-1518
OMs
H
H
H
H
H
OMe
OMe
COOH
H
H
H
COOH
O
—CH2CH═CCl2


I-1519
OMs
H
H
H
H
H
OMe
OMe
COOH
H
H
H
COOH
O
—CH2C≡CMe


I-1520
OMs
H
H
H
H
H
OMe
OMe
COOH
H
H
H
COOH
O
—CH2C6H4-4-Me


I-1521
OMs
H
H
H
H
H
OMe
OMe
COOH
H
H
H
CH2OH
O
—CH2CH═CMe2


I-1522
OMs
H
H
H
H
H
OMe
OMe
COOH
H
H
H
CH2OH
O
—(CH2)2CH═CMe2


I-1523
OMs
H
H
H
H
H
OMe
OMe
COOH
H
H
H
CH2OH
O
—CH2CH═CCl2


I-1524
OMs
H
H
H
H
H
OMe
OMe
COOH
H
H
H
CH2OH
O
—CH2C≡CMe


I-1525
OMs
H
H
H
H
H
OMe
OMe
COOH
H
H
H
CH2OH
O
—CH2C6H4-4-Me


I-1526
OMs
H
H
H
H
H
OMe
OMe
COOH
H
H
H
F
O
—CH2CH═CMe2


I-1527
OMs
H
H
H
H
H
OMe
OMe
COOH
H
H
H
F
O
—(CH2)2CH═CMe2


I-1528
OMs
H
H
H
H
H
OMe
OMe
COOH
H
H
H
F
O
—CH2CH═CCl2


I-1529
OMs
H
H
H
H
H
OMe
OMe
COOH
H
H
H
F
O
—CH2C≡CMe


I-1530
OMs
H
H
H
H
H
OMe
OMe
COOH
H
H
H
F
O
—CH2C6H4-4-Me


I-1531
OMs
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
OH
O
—(CH2)2CH═CMe2


I-1532
OMs
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
OH
O
—CH2CH═CCl2


I-1533
OMs
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
OH
O
—CH2C≡CMe


I-1534
OMs
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
OH
O
—CH2C6H4-4-Me


I-1535
OMs
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
OMs
O
—(CH2)2CH═CMe2


I-1536
OMs
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
OMs
O
—CH2CH═CCl2


I-1537
OMs
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
OMs
O
—CH2C≡CMe































TABLE 278







I-1538
OMs
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
OMs
O
—CH2C6H4-4-Me


I-1539
OMs
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
COOH
O
—CH2CH═CMe2


I-1540
OMs
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
COOH
O
—(CH2)2CH═CMe2


I-1541
OMs
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
COOH
O
—CH2CH═CCl2


I-1542
OMs
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
COOH
O
—CH2C≡CMe


I-1543
OMs
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
COOH
O
—CH2C6H4-4-Me


I-1544
OMs
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
CH2OH
O
—(CH2)2CH═CMe2


I-1545
OMs
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
CH2OH
O
—CH2CH═CCl2


I-1546
OMs
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
CH2OH
O
—CH2C≡CMe


I-1547
OMs
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
CH2OH
O
—CH2C6H4-4-Me


I-1548
OMs
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
F
O
—CH2CH═CMe2


I-1549
OMs
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
F
O
—(CH2)2CH═CMe2


I-1550
OMs
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
F
O
—CH2CH═CCl2


I-1551
OMs
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
F
O
—CH2C≡CMe


I-1552
OMs
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
F
O
—CH2C6H4-4-Me


I-1553
OMs
H
H
H
H
H
OMe
OMe
Me
H
H
H
OH
O
—CH2CH═CMe2


I-1554
OMs
H
H
H
H
H
OMe
OMe
Me
H
H
H
OH
O
—(CH2)2CH═CMe2


I-1555
OMs
H
H
H
H
H
OMe
OMe
Me
H
H
H
OH
O
—CH2CH═CCl2


I-1556
OMs
H
H
H
H
H
OMe
OMe
Me
H
H
H
OH
O
—CH2C≡CMe


I-1557
OMs
H
H
H
H
H
OMe
OMe
Me
H
H
H
OH
O
—CH2C6H4-4-Me


I-1558
OMs
H
H
H
H
H
OMe
OMe
Me
H
H
H
OMs
O
—CH2CH═CMe2































TABLE 279







I-1559
OMs
H
H
H
H
H
OMe
OMe
Me
H
H
H
OMs
O
—CH2CH═CCl2


I-1560
OMs
H
H
H
H
H
OMe
OMe
Me
H
H
H
OMs
O
—CH2C≡CMe


I-1561
OMs
H
H
H
H
H
OMe
OMe
Me
H
H
H
COOH
O
—CH2CH═CMe2


I-1562
OMs
H
H
H
H
H
OMe
OMe
Me
H
H
H
COOH
O
—(CH2)2CH═CMe2


I-1563
OMs
H
H
H
H
H
OMe
OMe
Me
H
H
H
COOH
O
—CH2CH═CCl2


I-1564
OMs
H
H
H
H
H
OMe
OMe
Me
H
H
H
COOH
O
—CH2C≡CMe


I-1565
OMs
H
H
H
H
H
OMe
OMe
Me
H
H
H
COOH
O
—CH2C6H4-4-Me


I-1566
OMs
H
H
H
H
H
OMe
OMe
Me
H
H
H
CH2OH
O
—CH2CH═CMe2


I-1567
OMs
H
H
H
H
H
OMe
OMe
Me
H
H
H
CH2OH
O
—(CH2)2CH═CMe2


I-1568
OMs
H
H
H
H
H
OMe
OMe
Me
H
H
H
CH2OH
O
—CH2CH═CCl2


I-1569
OMs
H
H
H
H
H
OMe
OMe
Me
H
H
H
CH2OH
O
—CH2C≡CMe


I-1570
OMs
H
H
H
H
H
OMe
OMe
Me
H
H
H
CH2OH
O
—CH2C6H4-4-Me


I-1571
OMs
H
H
H
H
H
OMe
OMe
Me
H
H
H
F
O
—CH2CH═CMe2


I-1572
OMs
H
H
H
H
H
OMe
OMe
Me
H
H
H
F
O
—(CH2)2CH═CMe2


I-1573
OMs
H
H
H
H
H
OMe
OMe
Me
H
H
H
F
O
—CH2CH═CCl2


I-1574
OMs
H
H
H
H
H
OMe
OMe
Me
H
H
H
F
O
—CH2C≡CMe


I-1575
OMs
H
H
H
H
H
OMe
OMe
Me
H
H
H
F
O
—CH2C6H4-4-Me


I-1576
OMs
H
H
H
H
H
OMe
OMe
H
H
H
H
OH
O
—CH2CH═CMe2


I-1577
OMs
H
H
H
H
H
OMe
OMe
H
H
H
H
OH
O
—(CH2)2CH═CMe2


I-1578
OMs
H
H
H
H
H
OMe
OMe
H
H
H
H
OH
O
—CH2CH═CCl2


I-1579
OMs
H
H
H
H
H
OMe
OMe
H
H
H
H
OH
O
—CH2C≡CMe































TABLE 280







I-1580
OMs
H
H
H
H
H
OMe
OMe
H
H
H
H
OH
O
—CH2C6H4-4-Me


I-1581
OMs
H
H
H
H
H
OMe
OMe
H
H
H
H
OMs
O
—CH2CH═CCl2


I-1582
OMs
H
H
H
H
H
OMe
OMe
H
H
H
H
OMs
O
—CH2C≡CMe


I-1583
OMs
H
H
H
H
H
OMe
OMe
H
H
H
H
COOH
O
—CH2CH═CMe2


I-1584
OMs
H
H
H
H
H
OMe
OMe
H
H
H
H
COOH
O
—(CH2)2CH═CMe2


I-1585
OMs
H
H
H
H
H
OMe
OMe
H
H
H
H
COOH
O
—CH2CH═CCl2


I-1586
OMs
H
H
H
H
H
OMe
OMe
H
H
H
H
COOH
O
—CH2C≡CMe


I-1587
OMs
H
H
H
H
H
OMe
OMe
H
H
H
H
COOH
O
—CH2C6H4-4-Me


I-1588
OMs
H
H
H
H
H
OMe
OMe
H
H
H
H
CH2OH
O
—CH2CH═CMe2


I-1589
OMs
H
H
H
H
H
OMe
OMe
H
H
H
H
CH2OH
O
—(CH2)2CH═CMe2


I-1590
OMs
H
H
H
H
H
OMe
OMe
H
H
H
H
CH2OH
O
—CH2CH═CCl2


I-1591
OMs
H
H
H
H
H
OMe
OMe
H
H
H
H
CH2OH
O
—CH2C≡CMe


I-1592
OMs
H
H
H
H
H
OMe
OMe
H
H
H
H
CH2OH
O
—CH2C6H4-4-Me


I-1593
OMs
H
H
H
H
H
OMe
OMe
H
H
H
H
F
O
—(CH2)2CH═CMe2


I-1594
OMs
H
H
H
H
H
OMe
OMe
H
H
H
H
F
O
—CH2CH═CCl2


I-1595
OMs
H
H
H
H
H
OMe
OMe
H
H
H
H
F
O
—CH2C≡CMe


I-1596
OMs
H
H
H
H
F
OMe
OMe
OH
H
H
H
OH
O
—CH2CH═CMe2


I-1597
OMs
H
H
H
H
F
OMe
OMe
OH
H
H
H
OH
O
—(CH2)2CH═CMe2


I-1598
OMs
H
H
H
H
F
OMe
OMe
OH
H
H
H
OH
O
—CH2CH═CCl2


I-1599
OMs
H
H
H
H
F
OMe
OMe
OH
H
H
H
OH
O
—CH2C≡CMe


I-1600
OMs
H
H
H
H
F
OMe
OMe
OH
H
H
H
OH
O
—CH2C6H4-4-Me































TABLE 281







I-1601
OMs
H
H
H
H
F
OMe
OMe
OH
H
H
H
OMs
O
—CH2CH═CMe2


I-1602
OMs
H
H
H
H
F
OMe
OMe
OH
H
H
H
OMs
O
—(CH2)2CH═CMe2


I-1603
OMs
H
H
H
H
F
OMe
OMe
OH
H
H
H
OMs
O
—CH2CH═CCl2


I-1604
OMs
H
H
H
H
F
OMe
OMe
OH
H
H
H
OMs
O
—CH2C≡CMe


I-1605
OMs
H
H
H
H
F
OMe
OMe
OH
H
H
H
OMs
O
—CH2C6H4-4-Me


I-1606
OMs
H
H
H
H
F
OMe
OMe
OH
H
H
H
COOH
O
—CH2CH═CMe2


I-1607
OMs
H
H
H
H
F
OMe
OMe
OH
H
H
H
COOH
O
—(CH2)2CH═CMe2


I-1608
OMs
H
H
H
H
F
OMe
OMe
OH
H
H
H
COOH
O
—CH2CH═CCl2


I-1609
OMs
H
H
H
H
F
OMe
OMe
OH
H
H
H
COOH
O
—CH2C≡CMe


I-1610
OMs
H
H
H
H
F
OMe
OMe
OH
H
H
H
COOH
O
—CH2C6H4-4-Me


I-1611
OMs
H
H
H
H
F
OMe
OMe
OH
H
H
H
CH2OH
O
—CH2CH═CMe2


I-1612
OMs
H
H
H
H
F
OMe
OMe
OH
H
H
H
CH2OH
O
—(CH2)2CH═CMe2


I-1613
OMs
H
H
H
H
F
OMe
OMe
OH
H
H
H
CH2OH
O
—CH2CH═CCl2


I-1614
OMs
H
H
H
H
F
OMe
OMe
OH
H
H
H
CH2OH
O
—CH2C≡CMe


I-1615
OMs
H
H
H
H
F
OMe
OMe
OH
H
H
H
CH2OH
O
—CH2C6H4-4-Me


I-1616
OMs
H
H
H
H
F
OMe
OMe
OH
H
H
H
F
O
—CH2CH═CMe2


I-1617
OMs
H
H
H
H
F
OMe
OMe
OH
H
H
H
F
O
—(CH2)2CH═CMe2


I-1618
OMs
H
H
H
H
F
OMe
OMe
OH
H
H
H
F
O
—CH2CH═CCl2


I-1619
OMs
H
H
H
H
F
OMe
OMe
OH
H
H
H
F
O
—CH2C≡CMe


I-1620
OMs
H
H
H
H
F
OMe
OMe
OH
H
H
H
F
O
—CH2C6H4-4-Me


I-1621
F
H
H
H
H
H
OMe
OMe
OH
H
H
H
OH
O
—CH2CH═CCl2































TABLE 282







I-1622
F
H
H
H
H
H
OMe
OMe
OH
H
H
H
OH
O
—CH2C≡CMe


I-1623
F
H
H
H
H
H
OMe
OMe
OH
H
H
H
OMs
O
—CH2CH═CCl2


I-1624
F
H
H
H
H
H
OMe
OMe
OH
H
H
H
OMs
O
—CH2C≡CMe


I-1625
F
H
H
H
H
H
OMe
OMe
OH
H
H
H
COOH
O
—CH2CH═CMe2


I-1626
F
H
H
H
H
H
OMe
OMe
OH
H
H
H
COOH
O
—(CH2)2CH═CMe2


I-1627
F
H
H
H
H
H
OMe
OMe
OH
H
H
H
COOH
O
—CH2CH═CCl2


I-1628
F
H
H
H
H
H
OMe
OMe
OH
H
H
H
COOH
O
—CH2C≡CMe


I-1629
F
H
H
H
H
H
OMe
OMe
OH
H
H
H
COOH
O
—CH2C6H4-4-Me


I-1630
F
H
H
H
H
H
OMe
OMe
OH
H
H
H
CH2OH
O
—CH2CH═CMe2


I-1631
F
H
H
H
H
H
OMe
OMe
OH
H
H
H
CH2OH
O
—(CH2)2CH═CMe2


I-1632
F
H
H
H
H
H
OMe
OMe
OH
H
H
H
CH2OH
O
—CH2CH═CCl2


I-1633
F
H
H
H
H
H
OMe
OMe
OH
H
H
H
CH2OH
O
—CH2C≡CMe


I-1634
F
H
H
H
H
H
OMe
OMe
OH
H
H
H
CH2OH
O
—CH2C6H4-4-Me


I-1635
F
H
H
H
H
H
OMe
OMe
OH
H
H
H
F
O
—CH2CH═CCl2


I-1636
F
H
H
H
H
H
OMe
OMe
OH
H
H
H
F
O
—CH2C≡CMe


I-1637
F
H
H
H
H
H
OMe
OMe
COOH
H
H
H
OH
O
—CH2CH═CCl2


I-1638
F
H
H
H
H
H
OMe
OMe
COOH
H
H
H
OH
O
—CH2C≡CMe


I-1639
F
H
H
H
H
H
OMe
OMe
COOH
H
H
H
OMs
O
—CH2CH═CMe2


I-1640
F
H
H
H
H
H
OMe
OMe
COOH
H
H
H
OMs
O
—(CH2)2CH═CMe2


I-1641
F
H
H
H
H
H
OMe
OMe
COOH
H
H
H
OMs
O
—CH2CH═CCl2


I-1642
F
H
H
H
H
H
OMe
OMe
COOH
H
H
H
OMs
O
—CH2C≡CMe































TABLE 283







I-1643
F
H
H
H
H
H
OMe
OMe
COOH
H
H
H
OMs
O
—CH2C6H4-4-Me


I-1644
F
H
H
H
H
H
OMe
OMe
COOH
H
H
H
COOH
O
—CH2CH═CMe2


I-1645
F
H
H
H
H
H
OMe
OMe
COOH
H
H
H
COOH
O
—(CH2)2CH═CMe2


I-1646
F
H
H
H
H
H
OMe
OMe
COOH
H
H
H
COOH
O
—CH2CH═CCl2


I-1647
F
H
H
H
H
H
OMe
OMe
COOH
H
H
H
COOH
O
—CH2C≡CMe


I-1648
F
H
H
H
H
H
OMe
OMe
COOH
H
H
H
COOH
O
—CH2C6H4-4-Me


I-1649
F
H
H
H
H
H
OMe
OMe
COOH
H
H
H
CH2OH
O
—CH2CH═CMe2


I-1650
F
H
H
H
H
H
OMe
OMe
COOH
H
H
H
CH2OH
O
—(CH2)2CH═CMe2


I-1651
F
H
H
H
H
H
OMe
OMe
COOH
H
H
H
CH2OH
O
—CH2CH═CCl2


I-1652
F
H
H
H
H
H
OMe
OMe
COOH
H
H
H
CH2OH
O
—CH2C≡CMe


I-1653
F
H
H
H
H
H
OMe
OMe
COOH
H
H
H
CH2OH
O
—CH2C6H4-4-Me


I-1654
F
H
H
H
H
H
OMe
OMe
COOH
H
H
H
F
O
—CH2CH═CCl2


I-1655
F
H
H
H
H
H
OMe
OMe
COOH
H
H
H
F
O
—CH2C≡CMe


I-1656
F
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
OH
O
—CH2CH═CMe2


I-1657
F
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
OH
O
—(CH2)2CH═CMe2


I-1658
F
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
OH
O
—CH2CH═CCl2


I-1659
F
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
OH
O
—CH2C≡CMe


I-1660
F
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
OH
O
—CH2C6H4-4-Me


I-1661
F
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
OMs
O
—CH2CH═CMe2


I-1662
F
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
OMs
O
—(CH2)2CH═CMe2


I-1663
F
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
OMs
O
—CH2CH═CCl2































TABLE 284







I-1664
F
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
OMs
O
—CH2C≡CMe


I-1665
F
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
OMs
O
—CH2C6H4-4-Me


I-1666
F
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
COOH
O
—CH2CH═CMe2


I-1667
F
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
COOH
O
—(CH2)2CH═CMe2


I-1668
F
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
COOH
O
—CH2CH═CCl2


I-1669
F
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
COOH
O
—CH2C≡CMe


I-1670
F
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
COOH
O
—CH2C6H4-4-Me


I-1671
F
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
CH2OH
O
—CH2CH═CMe2


I-1672
F
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
CH2OH
O
—(CH2)2CH═CMe2


I-1673
F
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
CH2OH
O
—CH2CH═CCl2


I-1674
F
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
CH2OH
O
—CH2C≡CMe


I-1675
F
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
CH2OH
O
—CH2C6H4-4-Me


I-1676
F
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
F
O
—CH2CH═CMe2


I-1677
F
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
F
O
—(CH2)2CH═CMe2


I-1678
F
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
F
O
—CH2CH═CCl2


I-1679
F
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
F
O
—CH2C≡CMe


I-1680
F
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
F
O
—CH2C6H4-4-Me


I-1681
F
H
H
H
H
H
OMe
OMe
Me
H
H
H
OH
O
—CH2CH═CMe2


I-1682
F
H
H
H
H
H
OMe
OMe
Me
H
H
H
OH
O
—(CH2)2CH═CMe2


I-1683
F
H
H
H
H
H
OMe
OMe
Me
H
H
H
OH
O
—CH2CH═CCl2


I-1684
F
H
H
H
H
H
OMe
OMe
Me
H
H
H
OH
O
—CH2C≡CMe































TABLE 285







I-1685
F
H
H
H
H
H
OMe
OMe
Me
H
H
H
OH
O
—CH2C6H4-4-Me


I-1686
F
H
H
H
H
H
OMe
OMe
Me
H
H
H
OMs
O
—CH2CH═CMe2


I-1687
F
H
H
H
H
H
OMe
OMe
Me
H
H
H
OMs
O
—(CH2)2CH═CMe2


I-1688
F
H
H
H
H
H
OMe
OMe
Me
H
H
H
OMs
O
—CH2CH═CCl2


I-1689
F
H
H
H
H
H
OMe
OMe
Me
H
H
H
OMs
O
—CH2C≡CMe


I-1690
F
H
H
H
H
H
OMe
OMe
Me
H
H
H
OMs
O
—CH2C6H4-4-Me


I-1691
F
H
H
H
H
H
OMe
OMe
Me
H
H
H
COOH
O
—CH2CH═CMe2


I-1692
F
H
H
H
H
H
OMe
OMe
Me
H
H
H
COOH
O
—(CH2)2CH═CMe2


I-1693
F
H
H
H
H
H
OMe
OMe
Me
H
H
H
COOH
O
—CH2CH═CCl2


I-1694
F
H
H
H
H
H
OMe
OMe
Me
H
H
H
COOH
O
—CH2C≡CMe


I-1695
F
H
H
H
H
H
OMe
OMe
Me
H
H
H
COOH
O
—CH2C6H4-4-Me


I-1696
F
H
H
H
H
H
OMe
OMe
Me
H
H
H
CH2OH
O
—CH2CH═CMe2


I-1697
F
H
H
H
H
H
OMe
OMe
Me
H
H
H
CH2OH
O
—(CH2)2CH═CMe2


I-1698
F
H
H
H
H
H
OMe
OMe
Me
H
H
H
CH2OH
O
—CH2CH═CCl2


I-1699
F
H
H
H
H
H
OMe
OMe
Me
H
H
H
CH2OH
O
—CH2C≡CMe


I-1700
F
H
H
H
H
H
OMe
OMe
Me
H
H
H
CH2OH
O
—CH2C6H4-4-Me


I-1701
F
H
H
H
H
H
OMe
OMe
Me
H
H
H
F
O
—CH2CH═CMe2


I-1702
F
H
H
H
H
H
OMe
OMe
Me
H
H
H
F
O
—(CH2)2CH═CMe2


I-1703
F
H
H
H
H
H
OMe
OMe
Me
H
H
H
F
O
—CH2CH═CCl2


I-1704
F
H
H
H
H
H
OMe
OMe
Me
H
H
H
F
O
—CH2C≡CMe


I-1705
F
H
H
H
H
H
OMe
OMe
Me
H
H
H
F
O
—CH2C6H4-4-Me































TABLE 286







I-1706
F
H
H
H
H
H
OMe
OMe
H
H
H
H
OH
O
—CH2CH═CMe2


I-1707
F
H
H
H
H
H
OMe
OMe
H
H
H
H
OH
O
—(CH2)2CH═CMe2


I-1708
F
H
H
H
H
H
OMe
OMe
H
H
H
H
OH
O
—CH2CH═CCl2


I-1709
F
H
H
H
H
H
OMe
OMe
H
H
H
H
OH
O
—CH2C≡CMe


I-1710
F
H
H
H
H
H
OMe
OMe
H
H
H
H
OH
O
—CH2C6H4-4-Me


I-1711
F
H
H
H
H
H
OMe
OMe
H
H
H
H
OMs
O
—(CH2)2CH═CMe2


I-1712
F
H
H
H
H
H
OMe
OMe
H
H
H
H
OMs
O
—CH2CH═CCl2


I-1713
F
H
H
H
H
H
OMe
OMe
H
H
H
H
OMs
O
—CH2C≡CMe


I-1714
F
H
H
H
H
H
OMe
OMe
H
H
H
H
OMs
O
—CH2C6H4-4-Me


I-1715
F
H
H
H
H
H
OMe
OMe
H
H
H
H
COOH
O
—CH2CH═CMe2


I-1716
F
H
H
H
H
H
OMe
OMe
H
H
H
H
COOH
O
—(CH2)2CH═CMe2


I-1717
F
H
H
H
H
H
OMe
OMe
H
H
H
H
COOH
O
—CH2CH═CCl2


I-1718
F
H
H
H
H
H
OMe
OMe
H
H
H
H
COOH
O
—CH2C≡CMe


I-1719
F
H
H
H
H
H
OMe
OMe
H
H
H
H
COOH
O
—CH2C6H4-4-Me


I-1720
F
H
H
H
H
H
OMe
OMe
H
H
H
H
CH2OH
O
—CH2CH═CMe2


I-1721
F
H
H
H
H
H
OMe
OMe
H
H
H
H
CH2OH
O
—(CH2)2CH═CMe2


I-1722
F
H
H
H
H
H
OMe
OMe
H
H
H
H
CH2OH
O
—CH2CH═CCl2


I-1723
F
H
H
H
H
H
OMe
OMe
H
H
H
H
CH2OH
O
—CH2C≡CMe


I-1724
F
H
H
H
H
H
OMe
OMe
H
H
H
H
CH2OH
O
—CH2C6H4-4-Me


I-1725
F
H
H
H
H
H
OMe
OMe
H
H
H
H
F
O
—CH2CH═CMe2


I-1726
F
H
H
H
H
H
OMe
OMe
H
H
H
H
F
O
—(CH2)2CH═CMe2































TABLE 287







I-1727
F
H
H
H
H
H
OMe
OMe
H
H
H
H
F
O
—CH2CH═CCl2


I-1728
F
H
H
H
H
H
OMe
OMe
H
H
H
H
F
O
—CH2C≡CMe


I-1729
F
H
H
H
H
H
OMe
OMe
H
H
H
H
F
O
—CH2C6H4-4-Me


I-1730
F
H
H
H
H
F
OMe
OMe
OH
H
H
H
OH
O
—(CH2)2CH═CMe2


I-1731
F
H
H
H
H
F
OMe
OMe
OH
H
H
H
OH
O
—CH2CH═CCl2


I-1732
F
H
H
H
H
F
OMe
OMe
OH
H
H
H
OH
O
—CH2C≡CMe


I-1733
F
H
H
H
H
F
OMe
OMe
OH
H
H
H
OH
O
—CH2C6H4-4-Me


I-1734
F
H
H
H
H
F
OMe
OMe
OH
H
H
H
OMs
O
—CH2CH═CMe2


I-1735
F
H
H
H
H
F
OMe
OMe
OH
H
H
H
OMs
O
—(CH2)2CH═CMe2


I-1736
F
H
H
H
H
F
OMe
OMe
OH
H
H
H
OMs
O
—CH2CH═CCl2


I-1737
F
H
H
H
H
F
OMe
OMe
OH
H
H
H
OMs
O
—CH2C≡CMe


I-1738
F
H
H
H
H
F
OMe
OMe
OH
H
H
H
OMs
O
—CH2C6H4-4-Me


I-1739
F
H
H
H
H
F
OMe
OMe
OH
H
H
H
COOH
O
—CH2CH═CMe2


I-1740
F
H
H
H
H
F
OMe
OMe
OH
H
H
H
COOH
O
—(CH2)2CH═CMe2


I-1741
F
H
H
H
H
F
OMe
OMe
OH
H
H
H
COOH
O
—CH2CH═CCl2


I-1742
F
H
H
H
H
F
OMe
OMe
OH
H
H
H
COOH
O
—CH2C≡CMe


I-1743
F
H
H
H
H
F
OMe
OMe
OH
H
H
H
COOH
O
—CH2C6H4-4-Me


I-1744
F
H
H
H
H
F
OMe
OMe
OH
H
H
H
CH2OH
O
—CH2CH═CMe2


I-1745
F
H
H
H
H
F
OMe
OMe
OH
H
H
H
CH2OH
O
—(CH2)2CH═CMe2


I-1746
F
H
H
H
H
F
OMe
OMe
OH
H
H
H
CH2OH
O
—CH2CH═CCl2


I-1747
F
H
H
H
H
F
OMe
OMe
OH
H
H
H
CH2OH
O
—CH2C≡CMe































TABLE 288







I-1748
F
H
H
H
H
F
OMe
OMe
OH
H
H
H
CH2OH
O
—CH2C6H4-4-Me


I-1749
F
H
H
H
H
F
OMe
OMe
OH
H
H
H
F
O
—CH2CH═CMe2


I-1750
F
H
H
H
H
F
OMe
OMe
OH
H
H
H
F
O
—(CH2)2CH═CMe2


I-1751
F
H
H
H
H
F
OMe
OMe
OH
H
H
H
F
O
—CH2CH═CCl2


I-1752
F
H
H
H
H
F
OMe
OMe
OH
H
H
H
F
O
—CH2C≡CMe


I-1753
F
H
H
H
H
F
OMe
OMe
OH
H
H
H
F
O
—CH2C6H4-4-Me


I-1754
—OCH2O— *
H
H
*
H
H
OMe
OMe
OH
H
H
H
OH
O
—CH2CH═CMe2


I-1755
—OCH2O— *
H
H
*
H
H
OMe
OMe
OH
H
H
H
OH
O
—(CH2)2CH═CMe2


I-1756
—OCH2O— *
H
H
*
H
H
OMe
OMe
OH
H
H
H
OH
O
—CH2CH═CCl2


I-1757
—OCH2O— *
H
H
*
H
H
OMe
OMe
OH
H
H
H
OH
O
—CH2C≡CMe


I-1758
—OCH2O— *
H
H
*
H
H
OMe
OMe
OH
H
H
H
OH
O
—CH2C6H4-4-Me


I-1759
—OCH2O— *
H
H
*
H
H
OMe
OMe
OH
H
H
H
OMs
O
—CH2CH═CMe2


I-1700
—OCH2O— *
H
H
*
H
H
OMe
OMe
OH
H
H
H
OMs
O
—(CH2)2CH═CMe2


I-1761
—OCH2O— *
H
H
*
H
H
OMe
OMe
OH
H
H
H
OMs
O
—CH2CH═CCl2


I-1762
—OCH2O— *
H
H
*
H
H
OMe
OMe
OH
H
H
H
OMs
O
—CH2C≡CMe


I-1763
—OCH2O— *
H
H
*
H
H
OMe
OMe
OH
H
H
H
OMs
O
—CH2C6H4-4-Me


I-1764
—OCH2O— *
H
H
*
H
H
OMe
OMe
OH
H
H
H
COOH
O
—CH2CH═CMe2


I-1765
—OCH2O— *
H
H
*
H
H
OMe
OMe
OH
H
H
H
COOH
O
—(CH2)2CH═CMe2


I-1766
—OCH2O— *
H
H
*
H
H
OMe
OMe
OH
H
H
H
COOH
O
—CH2CH═CCl2


I-1767
—OCH2O— *
H
H
*
H
H
OMe
OMe
OH
H
H
H
COOH
O
—CH2C≡CMe


I-1768
—OCH2O— *
H
H
*
H
H
OMe
OMe
OH
H
H
H
COOH
O
—CH2C6H4-4-Me































TABLE 289







I-1768
—OCH2O— *
H
H
*
H
H
OMe
OMe
OH
H
H
H
CH2OH
O
—CH2CH═CMe2


I-1769
—OCH2O— *
H
H
*
H
H
OMe
OMe
OH
H
H
H
CH2OH
O
—(CH2)2CH═CMe2


I-1770
—OCH2O— *
H
H
*
H
H
OMe
OMe
OH
H
H
H
CH2OH
O
—CH2CH═CCl2


I-1771
—OCH2O— *
H
H
*
H
H
OMe
OMe
OH
H
H
H
CH2OH
O
—CH2C≡CMe


I-1772
—OCH2O— *
H
H
*
H
H
OMe
OMe
OH
H
H
H
CH2OH
O
—CH2C6H4-4-Me


I-1773
—OCH2O— *
H
H
*
H
H
OMe
OMe
OH
H
H
H
F
O
—CH2CH═CMe2


I-1774
—OCH2O— *
H
H
*
H
H
OMe
OMe
OH
H
H
H
F
O
—(CH2)2CH═CMe2


I-1775
—OCH2O— *
H
H
*
H
H
OMe
OMe
OH
H
H
H
F
O
—CH2CH═CCl2


I-1776
—OCH2O— *
H
H
*
H
H
OMe
OMe
OH
H
H
H
F
O
—CH2C≡CMe


I-1777
—OCH2O— *
H
H
*
H
H
OMe
OMe
OH
H
H
H
F
O
—CH2C6H4-4-Me


I-1778
—OCH2O— *
H
H
*
H
H
OMe
OMe
COOH
H
H
H
OH
O
—CH2CH═CMe2


I-1779
—OCH2O— *
H
H
*
H
H
OMe
OMe
COOH
H
H
H
OH
O
—(CH2)2CH═CMe2


I-1780
—OCH2O— *
H
H
*
H
H
OMe
OMe
COOH
H
H
H
OH
O
—CH2CH═CCl2


I-1781
—OCH2O— *
H
H
*
H
H
OMe
OMe
COOH
H
H
H
OH
O
—CH2C≡CMe


I-1782
—OCH2O— *
H
H
*
H
H
OMe
OMe
COOH
H
H
H
OH
O
—CH2C6H4-4-Me


I-1783
—OCH2O— *
H
H
*
H
H
OMe
OMe
COOH
H
H
H
OMs
O
—CH2CH═CMe2


I-1784
—OCH2O— *
H
H
*
H
H
OMe
OMe
COOH
H
H
H
OMs
O
—(CH2)2CH═CMe2


I-1785
—OCH2O— *
H
H
*
H
H
OMe
OMe
COOH
H
H
H
OMs
O
—CH2CH═CCl2


I-1786
—OCH2O— *
H
H
*
H
H
OMe
OMe
COOH
H
H
H
OMs
O
—CH2C≡CMe


I-1787
—OCH2O— *
H
H
*
H
H
OMe
OMe
COOH
H
H
H
OMs
O
—CH2C6H4-4-Me


I-1788
—OCH2O— *
H
H
*
H
H
OMe
OMe
COOH
H
H
H
COOH
O
—CH2CH═CMe2































TABLE 290







I-1789
—OCH2O— *
H
H
*
H
H
OMe
OMe
COOH
H
H
H
COOH
O
—(CH2)2CH═CMe2


I-1790
—OCH2O— *
H
H
*
H
H
OMe
OMe
COOH
H
H
H
COOH
O
—CH2CH═CCl2


I-1791
—OCH2O— *
H
H
*
H
H
OMe
OMe
COOH
H
H
H
COOH
O
—CH2C≡CMe


I-1792
—OCH2O— *
H
H
*
H
H
OMe
OMe
COOH
H
H
H
COOH
O
—CH2C6H4-4-Me


I-1793
—OCH2O— *
H
H
*
H
H
OMe
OMe
COOH
H
H
H
CH2OH
O
—CH2CH═CMe2


I-1794
—OCH2O— *
H
H
*
H
H
OMe
OMe
COOH
H
H
H
CH2OH
O
—(CH2)2CH═CMe2


I-1795
—OCH2O— *
H
H
*
H
H
OMe
OMe
COOH
H
H
H
CH2OH
O
—CH2CH═CCl2


I-1796
—OCH2O— *
H
H
*
H
H
OMe
OMe
COOH
H
H
H
CH2OH
O
—CH2C≡CMe


I-1797
—OCH2O— *
H
H
*
H
H
OMe
OMe
COOH
H
H
H
CH2OH
O
—CH2C6H4-4-Me


I-1798
—OCH2O— *
H
H
*
H
H
OMe
OMe
COOH
H
H
H
F
O
—CH2CH═CMe2


I-1799
—OCH2O— *
H
H
*
H
H
OMe
OMe
COOH
H
H
H
F
O
—(CH2)2CH═CMe2


I-1800
—OCH2O— *
H
H
*
H
H
OMe
OMe
COOH
H
H
H
F
O
—CH2CH═CCl2


I-1801
—OCH2O— *
H
H
*
H
H
OMe
OMe
COOH
H
H
H
F
O
—CH2C≡CMe


I-1802
—OCH2O— *
H
H
*
H
H
OMe
OMe
COOH
H
H
H
F
O
—CH2C6H4-4-Me


I-1803
—OCH2O— *
H
H
*
H
H
OMe
OMe
CH2OH
H
H
H
OH
O
—CH2CH═CMe2


I-1804
—OCH2O— *
H
H
*
H
H
OMe
OMe
CH2OH
H
H
H
OH
O
—(CH2)2CH═CMe2


I-1805
—OCH2O— *
H
H
*
H
H
OMe
OMe
CH2OH
H
H
H
OH
O
—CH2CH═CCl2


I-1806
—OCH2O— *
H
H
*
H
H
OMe
OMe
CH2OH
H
H
H
OH
O
—CH2C≡CMe


I-1807
—OCH2O— *
H
H
*
H
H
OMe
OMe
CH2OH
H
H
H
OH
O
—CH2C6H4-4-Me


I-1808
—OCH2O— *
H
H
*
H
H
OMe
OMe
CH2OH
H
H
H
OMs
O
—CH2CH═CMe2


I-1809
—OCH2O— *
H
H
*
H
H
OMe
OMe
CH2OH
H
H
H
OMs
O
—(CH2)2CH═CMe2































TABLE 291







I-1810
—OCH2O— *
H
H
*
H
H
OMe
OMe
CH2OH
H
H
H
OMs
O
—CH2CH═CCl2


I-1811
—OCH2O— *
H
H
*
H
H
OMe
OMe
CH2OH
H
H
H
OMs
O
—CH2C≡CMe


I-1812
—OCH2O— *
H
H
*
H
H
OMe
OMe
CH2OH
H
H
H
OMs
O
—CH2C6H4-4-Me


I-1813
—OCH2O— *
H
H
*
H
H
OMe
OMe
CH2OH
H
H
H
COOH
O
—CH2CH═CMe2


I-1814
—OCH2O— *
H
H
*
H
H
OMe
OMe
CH2OH
H
H
H
COOH
O
—(CH2)2CH═CMe2


I-1815
—OCH2O— *
H
H
*
H
H
OMe
OMe
CH2OH
H
H
H
COOH
O
—CH2CH═CCl2


I-1816
—OCH2O— *
H
H
*
H
H
OMe
OMe
CH2OH
H
H
H
COOH
O
—CH2C≡CMe


I-1817
—OCH2O— *
H
H
*
H
H
OMe
OMe
CH2OH
H
H
H
COOH
O
—CH2C6H4-4-Me


I-1818
—OCH2O— *
H
H
*
H
H
OMe
OMe
CH2OH
H
H
H
CH2OH
O
—CH2CH═CMe2


I-1819
—OCH2O— *
H
H
*
H
H
OMe
OMe
CH2OH
H
H
H
CH2OH
O
—(CH2)2CH═CMe2


I-1820
—OCH2O— *
H
H
*
H
H
OMe
OMe
CH2OH
H
H
H
CH2OH
O
—CH2CH═CCl2


I-1821
—OCH2O— *
H
H
*
H
H
OMe
OMe
CH2OH
H
H
H
CH2OH
O
—CH2C≡CMe


I-1822
—OCH2O— *
H
H
*
H
H
OMe
OMe
CH2OH
H
H
H
CH2OH
O
—CH2C6H4-4-Me


I-1823
—OCH2O— *
H
H
*
H
H
OMe
OMe
CH2OH
H
H
H
F
O
—CH2CH═CMe2


I-1824
—OCH2O— *
H
H
*
H
H
OMe
OMe
CH2OH
H
H
H
F
O
—(CH2)2CH═CMe2


I-1825
—OCH2O— *
H
H
*
H
H
OMe
OMe
CH2OH
H
H
H
F
O
—CH2CH═CCl2


I-1826
—OCH2O— *
H
H
*
H
H
OMe
OMe
CH2OH
H
H
H
F
O
—CH2C≡CMe


I-1827
—OCH2O— *
H
H
*
H
H
OMe
OMe
CH2OH
H
H
H
F
O
—CH2C6H4-4-Me


I-1828
—OCH2O— *
H
H
*
H
H
OMe
OMe
Me
H
H
H
OH
O
—CH2CH═CMe2


I-1829
—OCH2O— *
H
H
*
H
H
OMe
OMe
Me
H
H
H
OH
O
—(CH2)2CH═CMe2


I-1830
—OCH2O— *
H
H
*
H
H
OMe
OMe
Me
H
H
H
OH
O
—CH2CH═CCl2































TABLE 292







I-1831
—OCH2O— *
H
H
*
H
H
OMe
OMe
Me
H
H
H
OH
O
—CH2C≡CMe


I-1832
—OCH2O— *
H
H
*
H
H
OMe
OMe
Me
H
H
H
OH
O
—CH2C6H4-4-Me


I-1833
—OCH2O— *
H
H
*
H
H
OMe
OMe
Me
H
H
H
OMs
O
—CH2CH═CMe2


I-1834
—OCH2O— *
H
H
*
H
H
OMe
OMe
Me
H
H
H
OMs
O
—(CH2)2CH═CMe2


I-1835
—OCH2O— *
H
H
*
H
H
OMe
OMe
Me
H
H
H
OMs
O
—CH2CH═CCl2


I-1836
—OCH2O— *
H
H
*
H
H
OMe
OMe
Me
H
H
H
OMs
O
—CH2C≡CMe


I-1837
—OCH2O— *
H
H
*
H
H
OMe
OMe
Me
H
H
H
OMs
O
—CH2C6H4-4-Me


I-1838
—OCH2O— *
H
H
*
H
H
OMe
OMe
Me
H
H
H
COOH
O
—CH2CH═CMe2


I-1839
—OCH2O— *
H
H
*
H
H
OMe
OMe
Me
H
H
H
COOH
O
—(CH2)2CH═CMe2


I-1840
—OCH2O— *
H
H
*
H
H
OMe
OMe
Me
H
H
H
COOH
O
—CH2CH═CCl2


I-1841
—OCH2O— *
H
H
*
H
H
OMe
OMe
Me
H
H
H
COOH
O
—CH2C≡CMe


I-1842
—OCH2O— *
H
H
*
H
H
OMe
OMe
Me
H
H
H
COOH
O
—CH2C6H4-4-Me


I-1843
—OCH2O— *
H
H
*
H
H
OMe
OMe
Me
H
H
H
CH2OH
O
—CH2CH═CMe2


I-1844
—OCH2O— *
H
H
*
H
H
OMe
OMe
Me
H
H
H
CH2OH
O
—(CH2)2CH═CMe2


I-1845
—OCH2O— *
H
H
*
H
H
OMe
OMe
Me
H
H
H
CH2OH
O
—CH2CH═CCl2


I-1846
—OCH2O— *
H
H
*
H
H
OMe
OMe
Me
H
H
H
CH2OH
O
—CH2C≡CMe


I-1847
—OCH2O— *
H
H
*
H
H
OMe
OMe
Me
H
H
H
CH2OH
O
—CH2C6H4-4-Me


I-1848
—OCH2O— *
H
H
*
H
H
OMe
OMe
Me
H
H
H
F
O
—CH2CH═CMe2


I-1849
—OCH2O— *
H
H
*
H
H
OMe
OMe
Me
H
H
H
F
O
—(CH2)2CH═CMe2


I-1850
—OCH2O— *
H
H
*
H
H
OMe
OMe
Me
H
H
H
F
O
—CH2CH═CCl2


I-1851
—OCH2O— *
H
H
*
H
H
OMe
OMe
Me
H
H
H
F
O
—CH2C≡CMe































TABLE 292







I-1852
—OCH2O— *
H
H
*
H
H
OMe
OMe
Me
H
H
H
F
O
—CH2C6H4-4-Me


I-1853
—OCH2O— *
H
H
*
H
H
OMe
OMe
H
H
H
H
OH
O
—CH2CH═CMe2


I-1854
—OCH2O— *
H
H
*
H
H
OMe
OMe
H
H
H
H
OH
O
—(CH2)2CH═CMe2


I-1855
—OCH2O— *
H
H
*
H
H
OMe
OMe
H
H
H
H
OH
O
—CH2CH═CCl2


I-1856
—OCH2O— *
H
H
*
H
H
OMe
OMe
H
H
H
H
OH
O
—CH2C≡CMe


I-1857
—OCH2O— *
H
H
*
H
H
OMe
OMe
H
H
H
H
OH
O
—CH2C6H4-4-Me


I-1858
—OCH2O— *
H
H
*
H
H
OMe
OMe
H
H
H
H
OMs
O
—CH2CH═CMe2


I-1859
—OCH2O— *
H
H
*
H
H
OMe
OMe
H
H
H
H
OMs
O
—(CH2)2CH═CMe2


I-1800
—OCH2O— *
H
H
*
H
H
OMe
OMe
H
H
H
H
OMs
O
—CH2CH═CCl2


I-1861
—OCH2O— *
H
H
*
H
H
OMe
OMe
H
H
H
H
OMs
O
—CH2C≡CMe


I-1862
—OCH2O— *
H
H
*
H
H
OMe
OMe
H
H
H
H
OMs
O
—CH2C6H4-4-Me


I-1863
—OCH2O— *
H
H
*
H
H
OMe
OMe
H
H
H
H
COOH
O
—CH2CH═CMe2


I-1864
—OCH2O— *
H
H
*
H
H
OMe
OMe
H
H
H
H
COOH
O
—(CH2)2CH═CMe2


I-1865
—OCH2O— *
H
H
*
H
H
OMe
OMe
H
H
H
H
COOH
O
—CH2CH═CCl2


I-1866
—OCH2O— *
H
H
*
H
H
OMe
OMe
H
H
H
H
COOH
O
—CH2C≡CMe


I-1867
—OCH2O— *
H
H
*
H
H
OMe
OMe
H
H
H
H
COOH
O
—CH2C6H4-4-Me


I-1868
—OCH2O— *
H
H
*
H
H
OMe
OMe
H
H
H
H
CH2OH
O
—CH2CH═CMe2


I-1869
—OCH2O— *
H
H
*
H
H
OMe
OMe
H
H
H
H
CH2OH
O
—(CH2)2CH═CMe2


I-1870
—OCH2O— *
H
H
*
H
H
OMe
OMe
H
H
H
H
CH2OH
O
—CH2CH═CCl2


I-1871
—OCH2O— *
H
H
*
H
H
OMe
OMe
H
H
H
H
CH2OH
O
—CH2C≡CMe


I-1872
—OCH2O— *
H
H
*
H
H
OMe
OMe
H
H
H
H
CH2OH
O
—CH2C6H4-4-Me































TABLE 292







I-1873
—OCH2O— *
H
H
*
H
H
OMe
OMe
H
H
H
H
F
O
—CH2CH═CMe2


I-1874
—OCH2O— *
H
H
*
H
H
OMe
OMe
H
H
H
H
F
O
—(CH2)2CH═CMe2


I-1875
—OCH2O— *
H
H
*
H
H
OMe
OMe
H
H
H
H
F
O
—CH2CH═CCl2


I-1876
—OCH2O— *
H
H
*
H
H
OMe
OMe
H
H
H
H
F
O
—CH2C≡CMe


I-1877
—OCH2O— *
H
H
*
H
H
OMe
OMe
H
H
H
H
F
O
—CH2C6H4-4-Me


I-1878
—OCH2O— *
H
H
*
H
F
OMe
OMe
H
H
H
H
OH
O
—CH2CH═CMe2


I-1879
—OCH2O— *
H
H
*
H
F
OMe
OMe
H
H
H
H
OH
O
—(CH2)2CH═CMe2


I-1880
—OCH2O— *
H
H
*
H
F
OMe
OMe
H
H
H
H
OH
O
—CH2CH═CCl2


I-1881
—OCH2O— *
H
H
*
H
F
OMe
OMe
H
H
H
H
OH
O
—CH2C≡CMe


I-1882
—OCH2O— *
H
H
*
H
F
OMe
OMe
H
H
H
H
OH
O
—CH2C6H4-4-Me


I-1883
—OCH2O— *
H
H
*
H
F
OMe
OMe
H
H
H
H
OMs
O
—CH2CH═CMe2


I-1884
—OCH2O— *
H
H
*
H
F
OMe
OMe
H
H
H
H
OMs
O
—(CH2)2CH═CMe2


I-1885
—OCH2O— *
H
H
*
H
F
OMe
OMe
H
H
H
H
OMs
O
—CH2CH═CCl2


I-1886
—OCH2O— *
H
H
*
H
F
OMe
OMe
H
H
H
H
OMs
O
—CH2C≡CMe


I-1887
—OCH2O— *
H
H
*
H
F
OMe
OMe
H
H
H
H
OMs
O
—CH2C6H4-4-Me


I-1888
—OCH2O— *
H
H
*
H
F
OMe
OMe
H
H
H
H
COOH
O
—CH2CH═CMe2


I-1889
—OCH2O— *
H
H
*
H
F
OMe
OMe
H
H
H
H
COOH
O
—(CH2)2CH═CMe2


I-1890
—OCH2O— *
H
H
*
H
F
OMe
OMe
H
H
H
H
COOH
O
—CH2CH═CCl2


I-1891
—OCH2O— *
H
H
*
H
F
OMe
OMe
H
H
H
H
COOH
O
—CH2C≡CMe


I-1892
—OCH2O— *
H
H
*
H
F
OMe
OMe
H
H
H
H
COOH
O
—CH2C6H4-4-Me


I-1893
—OCH2O— *
H
H
*
H
F
OMe
OMe
H
H
H
H
CH2OH
O
—CH2CH═CMe2































TABLE 295







I-1894
—OCH2O— *
H
H
*
H
F
OMe
OMe
OH
H
H
H
CH2OH
O
—(CH2)2CH═CMe2


I-1895
—OCH2O— *
H
H
*
H
F
OMe
OMe
OH
H
H
H
CH2OH
O
—CH2CH═CCl2


I-1896
—OCH2O— *
H
H
*
H
F
OMe
OMe
OH
H
H
H
CH2OH
O
—CH2C≡CMe


I-1897
—OCH2O— *
H
H
*
H
F
OMe
OMe
OH
H
H
H
CH2OH
O
—CH2C6H4-4-Me


I-1898
—OCH2O— *
H
H
*
H
F
OMe
OMe
OH
H
H
H
F
O
—CH2CH═CMe2


I-1899
—OCH2O— *
H
H
*
H
F
OMe
OMe
OH
H
H
H
F
O
—(CH2)2CH═CMe2


I-1900
—OCH2O— *
H
H
*
H
F
OMe
OMe
OH
H
H
H
F
O
—CH2CH═CCl2


I-1901
—OCH2O— *
H
H
*
H
F
OMe
OMe
OH
H
H
H
F
O
—CH2C≡CMe


I-1902
—OCH2O— *
H
H
*
H
F
OMe
OMe
OH
H
H
H
F
O
—CH2C6H4-4-Me


I-1903
NMe2
H
H
H
H
H
OMe
OMe
OH
H
H
H
OH
O
—(CH2)2CH═CMe2


I-1904
NMe2
H
H
H
H
H
OMe
OMe
OH
H
H
H
OH
O
—CH2CH═CCl2


I-1905
NMe2
H
H
H
H
H
OMe
OMe
OH
H
H
H
OH
O
—CH2C≡CMe


I-1906
NMe2
H
H
H
H
H
OMe
OMe
OH
H
H
H
OMs
O
—CH2CH═CMe2


I-1907
NMe2
H
H
H
H
H
OMe
OMe
OH
H
H
H
OMs
O
—(CH2)2CH═CMe2


I-1908
NMe2
H
H
H
H
H
OMe
OMe
OH
H
H
H
OMs
O
—CH2CH═CCl2


I-1909
NMe2
H
H
H
H
H
OMe
OMe
OH
H
H
H
OMs
O
—CH2C≡CMe


I-1910
NMe2
H
H
H
H
H
OMe
OMe
OH
H
H
H
OMs
O
—CH2C6H4-4-Me


I-1911
NMe2
H
H
H
H
H
OMe
OMe
OH
H
H
H
COOH
O
—CH2CH═CMe2


I-1912
NMe2
H
H
H
H
H
OMe
OMe
OH
H
H
H
COOH
O
—(CH2)2CH═CMe2


I-1913
NMe2
H
H
H
H
H
OMe
OMe
OH
H
H
H
COOH
O
—CH2CH═CCl2


I-1914
NMe2
H
H
H
H
H
OMe
OMe
OH
H
H
H
COOH
O
—CH2C≡CMe































TABLE 296







I-1915
NMe2
H
H
H
H
H
OMe
OMe
OH
H
H
H
COOH
O
—CH2C6H4-4-Me


I-1916
NMe2
H
H
H
H
H
OMe
OMe
OH
H
H
H
CH2OH
O
—CH2CH═CMe2


I-1917
NMe2
H
H
H
H
H
OMe
OMe
OH
H
H
H
CH2OH
O
—(CH2)2CH═CMe2


I-1918
NMe2
H
H
H
H
H
OMe
OMe
OH
H
H
H
CH2OH
O
—CH2CH═CCl2


I-1919
NMe2
H
H
H
H
H
OMe
OMe
OH
H
H
H
CH2OH
O
—CH2C≡CMe


I-1920
NMe2
H
H
H
H
H
OMe
OMe
OH
H
H
H
CH2OH
O
—CH2C6H4-4-Me


I-1921
NMe2
H
H
H
H
H
OMe
OMe
OH
H
H
H
F
O
—CH2CH═CMe2


I-1922
NMe2
H
H
H
H
H
OMe
OMe
OH
H
H
H
F
O
—(CH2)2CH═CMe2


I-1923
NMe2
H
H
H
H
H
OMe
OMe
OH
H
H
H
F
O
—CH2CH═CCl2


I-1924
NMe2
H
H
H
H
H
OMe
OMe
OH
H
H
H
F
O
—CH2C≡CMe


I-1925
NMe2
H
H
H
H
H
OMe
OMe
OH
H
H
H
F
O
—CH2C6H4-4-Me


I-1926
NMe2
H
H
H
H
H
OMe
OMe
COOH
H
H
H
OH
O
—CH2CH═CMe2


I-1927
NMe2
H
H
H
H
H
OMe
OMe
COOH
H
H
H
OH
O
—(CH2)2CH═CMe2


I-1928
NMe2
H
H
H
H
H
OMe
OMe
COOH
H
H
H
OH
O
—CH2CH═CCl2


I-1929
NMe2
H
H
H
H
H
OMe
OMe
COOH
H
H
H
OH
O
—CH2C≡CMe


I-1930
NMe2
H
H
H
H
H
OMe
OMe
COOH
H
H
H
OH
O
—CH2C6H4-4-Me


I-1931
NMe2
H
H
H
H
H
OMe
OMe
COOH
H
H
H
OMs
O
—CH2CH═CMe2


I-1932
NMe2
H
H
H
H
H
OMe
OMe
COOH
H
H
H
OMs
O
—(CH2)2CH═CMe2


I-1933
NMe2
H
H
H
H
H
OMe
OMe
COOH
H
H
H
OMs
O
—CH2CH═CCl2


I-1934
NMe2
H
H
H
H
H
OMe
OMe
COOH
H
H
H
OMs
O
—CH2C≡CMe


I-1935
NMe2
H
H
H
H
H
OMe
OMe
COOH
H
H
H
OMs
O
—CH2C6H4-4-Me































TABLE 297







I-1936
NMe2
H
H
H
H
H
OMe
OMe
COOH
H
H
H
COOH
O
—CH2CH═CMe2


I-1937
NMe2
H
H
H
H
H
OMe
OMe
COOH
H
H
H
COOH
O
—(CH2)2CH═CMe2


I-1938
NMe2
H
H
H
H
H
OMe
OMe
COOH
H
H
H
COOH
O
—CH2CH═CCl2


I-199
NMe2
H
H
H
H
H
OMe
OMe
COOH
H
H
H
COOH
O
—CH2C≡CMe


I-190
NMe2
H
H
H
H
H
OMe
OMe
COOH
H
H
H
COOH
O
—CH2C6H4-4-Me


I-1941
NMe2
H
H
H
H
H
OMe
OMe
COOH
H
H
H
CH2OH
O
—CH2CH═CMe2


I-1942
NMe2
H
H
H
H
H
OMe
OMe
COOH
H
H
H
CH2OH
O
—(CH2)2CH═CMe2


I-1943
NMe2
H
H
H
H
H
OMe
OMe
COOH
H
H
H
CH2OH
O
—CH2CH═CCl2


I-1944
NMe2
H
H
H
H
H
OMe
OMe
COOH
H
H
H
CH2OH
O
—CH2C≡CMe


I-1945
NMe2
H
H
H
H
H
OMe
OMe
COOH
H
H
H
CH2OH
O
—CH2C6H4-4-Me


I-1946
NMe2
H
H
H
H
H
OMe
OMe
COOH
H
H
H
F
O
—CH2CH═CMe2


I-1947
NMe2
H
H
H
H
H
OMe
OMe
COOH
H
H
H
F
O
—(CH2)2CH═CMe2


I-1948
NMe2
H
H
H
H
H
OMe
OMe
COOH
H
H
H
F
O
—CH2CH═CCl2


I-1949
NMe2
H
H
H
H
H
OMe
OMe
COOH
H
H
H
F
O
—CH2C≡CMe


I-1950
NMe2
H
H
H
H
H
OMe
OMe
COOH
H
H
H
F
O
—CH2C6H4-4-Me


I-1951
NMe2
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
OH
O
—CH2CH═CMe2


I-1952
NMe2
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
OH
O
—(CH2)2CH═CMe2


I-1953
NMe2
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
OH
O
—CH2CH═CCl2


I-1954
NMe2
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
OH
O
—CH2C≡CMe


I-1955
NMe2
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
OH
O
—CH2C6H4-4-Me


I-1956
NMe2
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
OMs
O
—CH2CH═CMe2































TABLE 298







I-1957
NMe2
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
OMs
O
—(CH2)2CH═CMe2


I-1958
NMe2
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
OMs
O
—CH2CH═CCl2


I-1959
NMe2
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
OMs
O
—CH2C≡CMe


I-1960
NMe2
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
OMs
O
—CH2C6H4-4-Me


I-1961
NMe2
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
COOH
O
—CH2CH═CMe2


I-1962
NMe2
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
COOH
O
—(CH2)2CH═CMe2


I-1963
NMe2
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
COOH
O
—CH2CH═CCl2


I-1964
NMe2
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
COOH
O
—CH2C≡CMe


I-1965
NMe2
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
COOH
O
—CH2C6H4-4-Me


I-1966
NMe2
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
CH2OH
O
—CH2CH═CMe2


I-1967
NMe2
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
CH2OH
O
—(CH2)2CH═CMe2


I-1968
NMe2
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
CH2OH
O
—CH2CH═CCl2


I-1969
NMe2
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
CH2OH
O
—CH2C≡CMe


I-1970
NMe2
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
CH2OH
O
—CH2C6H4-4-Me


I-1971
NMe2
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
F
O
—CH2CH═CMe2


I-1972
NMe2
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
F
O
—(CH2)2CH═CMe2


I-1973
NMe2
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
F
O
—CH2CH═CCl2


I-1974
NMe2
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
F
O
—CH2C≡CMe


I-1975
NMe2
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
F
O
—CH2C6H4-4-Me


I-1976
NMe2
H
H
H
H
H
OMe
OMe
Me
H
H
H
OH
O
—CH2CH═CMe2


I-1977
NMe2
H
H
H
H
H
OMe
OMe
Me
H
H
H
OH
O
—(CH2)2CH═CMe2































TABLE 299







I-1978
NMe2
H
H
H
H
H
OMe
OMe
Me
H
H
H
OH
O
—CH2CH═CCl2


I-1979
NMe2
H
H
H
H
H
OMe
OMe
Me
H
H
H
OH
O
—CH2C≡CMe


I-1980
NMe2
H
H
H
H
H
OMe
OMe
Me
H
H
H
OH
O
—CH2C6H4-4-Me


I-1981
NMe2
H
H
H
H
H
OMe
OMe
Me
H
H
H
OMs
O
—CH2CH═CMe2


I-1982
NMe2
H
H
H
H
H
OMe
OMe
Me
H
H
H
OMs
O
—(CH2)2CH═CMe2


I-1983
NMe2
H
H
H
H
H
OMe
OMe
Me
H
H
H
OMs
O
—CH2CH═CCl2


I-1984
NMe2
H
H
H
H
H
OMe
OMe
Me
H
H
H
OMs
O
—CH2C≡CMe


I-1985
NMe2
H
H
H
H
H
OMe
OMe
Me
H
H
H
OMs
O
—CH2C6H4-4-Me


I-1986
NMe2
H
H
H
H
H
OMe
OMe
Me
H
H
H
COOH
O
—CH2CH═CMe2


I-1987
NMe2
H
H
H
H
H
OMe
OMe
Me
H
H
H
COOH
O
—(CH2)2CH═CMe2


I-1988
NMe2
H
H
H
H
H
OMe
OMe
Me
H
H
H
COOH
O
—CH2CH═CCl2


I-1989
NMe2
H
H
H
H
H
OMe
OMe
Me
H
H
H
COOH
O
—CH2C≡CMe


I-1990
NMe2
H
H
H
H
H
OMe
OMe
Me
H
H
H
COOH
O
—CH2C6H4-4-Me


I-1991
NMe2
H
H
H
H
H
OMe
OMe
Me
H
H
H
CH2OH
O
—CH2CH═CMe2


I-1992
NMe2
H
H
H
H
H
OMe
OMe
Me
H
H
H
CH2OH
O
—(CH2)2CH═CMe2


I-1993
NMe2
H
H
H
H
H
OMe
OMe
Me
H
H
H
CH2OH
O
—CH2CH═CCl2


I-1994
NMe2
H
H
H
H
H
OMe
OMe
Me
H
H
H
CH2OH
O
—CH2C≡CMe


I-1995
NMe2
H
H
H
H
H
OMe
OMe
Me
H
H
H
CH2OH
O
—CH2C6H4-4-Me


I-1996
NMe2
H
H
H
H
H
OMe
OMe
Me
H
H
H
F
O
—CH2CH═CMe2


I-1997
NMe2
H
H
H
H
H
OMe
OMe
Me
H
H
H
F
O
—(CH2)2CH═CMe2


I-1998
NMe2
H
H
H
H
H
OMe
OMe
Me
H
H
H
F
O
—CH2CH═CCl2































TABLE 300







I-1999
NMe2
H
H
H
H
H
OMe
OMe
Me
H
H
H
F
O
—CH2C≡CMe


I-2000
NMe2
H
H
H
H
H
OMe
OMe
Me
H
H
H
F
O
—CH2C6H4-4-Me


I-2001
NMe2
H
H
H
H
H
OMe
OMe
Me
H
H
H
OH
O
—CH2CH═CMe2


I-2002
NMe2
H
H
H
H
H
OMe
OMe
Me
H
H
H
OH
O
—(CH2)2CH═CMe2


I-2003
NMe2
H
H
H
H
H
OMe
OMe
Me
H
H
H
OH
O
—CH2CH═CCl2


I-2004
NMe2
H
H
H
H
H
OMe
OMe
Me
H
H
H
OH
O
—CH2C≡CMe


I-2005
NMe2
H
H
H
H
H
OMe
OMe
Me
H
H
H
OH
O
—CH2C6H4-4-Me


I-2006
NMe2
H
H
H
H
H
OMe
OMe
Me
H
H
H
OMs
O
—CH2CH═CMe2


I-2007
NMe2
H
H
H
H
H
OMe
OMe
Me
H
H
H
OMs
O
—(CH2)2CH═CMe2


I-2008
NMe2
H
H
H
H
H
OMe
OMe
Me
H
H
H
OMs
O
—CH2CH═CCl2


I-2009
NMe2
H
H
H
H
H
OMe
OMe
Me
H
H
H
OMs
O
—CH2C≡CMe


I-2010
NMe2
H
H
H
H
H
OMe
OMe
Me
H
H
H
OMs
O
—CH2C6H4-4-Me


I-2011
NMe2
H
H
H
H
H
OMe
OMe
Me
H
H
H
COOH
O
—CH2CH═CMe2


I-2012
NMe2
H
H
H
H
H
OMe
OMe
Me
H
H
H
COOH
O
—(CH2)2CH═CMe2


I-2013
NMe2
H
H
H
H
H
OMe
OMe
Me
H
H
H
COOH
O
—CH2CH═CCl2


I-2014
NMe2
H
H
H
H
H
OMe
OMe
Me
H
H
H
COOH
O
—CH2C≡CMe


I-2015
NMe2
H
H
H
H
H
OMe
OMe
Me
H
H
H
COOH
O
—CH2C6H4-4-Me


I-2016
NMe2
H
H
H
H
H
OMe
OMe
Me
H
H
H
CH2OH
O
—CH2CH═CMe2


I-2017
NMe2
H
H
H
H
H
OMe
OMe
Me
H
H
H
CH2OH
O
—(CH2)2CH═CMe2


I-2018
NMe2
H
H
H
H
H
OMe
OMe
Me
H
H
H
CH2OH
O
—CH2CH═CCl2


I-2019
NMe2
H
H
H
H
H
OMe
OMe
Me
H
H
H
CH2OH
O
—CH2C≡CMe































TABLE 301







I-2020
NMe2
H
H
H
H
H
OMe
OMe
H
H
H
H
CH2OH
O
—CH2C6H4-4-Me


I-2021
NMe2
H
H
H
H
H
OMe
OMe
H
H
H
H
F
O
—CH2CH═CMe2


I-2022
NMe2
H
H
H
H
H
OMe
OMe
H
H
H
H
F
O
—(CH2)2CH═CMe2


I-2023
NMe2
H
H
H
H
H
OMe
OMe
H
H
H
H
F
O
—CH2CH═CCl2


I-2024
NMe2
H
H
H
H
H
OMe
OMe
H
H
H
H
F
O
—CH2C≡CMe


I-2025
NMe2
H
H
H
H
H
OMe
OMe
H
H
H
H
F
O
—CH2C6H4-4-Me


I-2026
NMe2
H
H
H
H
F
OMe
OMe
OH
H
H
H
OH
O
—CH2CH═CMe2


I-2027
NMe2
H
H
H
H
F
OMe
OMe
OH
H
H
H
OH
O
—(CH2)2CH═CMe2


I-2028
NMe2
H
H
H
H
F
OMe
OMe
OH
H
H
H
OH
O
—CH2CH═CCl2


I-2029
NMe2
H
H
H
H
F
OMe
OMe
OH
H
H
H
OH
O
—CH2C≡CMe


I-2030
NMe2
H
H
H
H
F
OMe
OMe
OH
H
H
H
OH
O
—CH2C6H4-4-Me


I-2031
NMe2
H
H
H
H
F
OMe
OMe
OH
H
H
H
OMs
O
—CH2CH═CMe2


I-2032
NMe2
H
H
H
H
F
OMe
OMe
OH
H
H
H
OMs
O
—(CH2)2CH═CMe2


I-2033
NMe2
H
H
H
H
F
OMe
OMe
OH
H
H
H
OMs
O
—CH2CH═CCl2


I-2034
NMe2
H
H
H
H
F
OMe
OMe
OH
H
H
H
OMs
O
—CH2C≡CMe


I-2035
NMe2
H
H
H
H
F
OMe
OMe
OH
H
H
H
OMs
O
—CH2C6H4-4-Me


I-2036
NMe2
H
H
H
H
F
OMe
OMe
OH
H
H
H
COOH
O
—CH2CH═CMe2


I-2037
NMe2
H
H
H
H
F
OMe
OMe
OH
H
H
H
COOH
O
—(CH2)2CH═CMe2


I-2038
NMe2
H
H
H
H
F
OMe
OMe
OH
H
H
H
COOH
O
—CH2CH═CCl2


I-2039
NMe2
H
H
H
H
F
OMe
OMe
OH
H
H
H
COOH
O
—CH2C≡CMe


I-2040
NMe2
H
H
H
H
F
OMe
OMe
OH
H
H
H
COOH
O
—CH2C6H4-4-Me































TABLE 302







I-2041
NMe2
H
H
H
H
F
OMe
OMe
OH
H
H
H
CH2OH
O
—CH2CH═CMe2


I-2042
NMe2
H
H
H
H
F
OMe
OMe
OH
H
H
H
CH2OH
O
—(CH2)2CH═CMe2


I-2043
NMe2
H
H
H
H
F
OMe
OMe
OH
H
H
H
CH2OH
O
—CH2CH═CCl2


I-2044
NMe2
H
H
H
H
F
OMe
OMe
OH
H
H
H
CH2OH
O
—CH2C≡CMe


I-2045
NMe2
H
H
H
H
F
OMe
OMe
OH
H
H
H
CH2OH
O
—CH2C6H4-4-Me


I-2046
NMe2
H
H
H
H
F
OMe
OMe
OH
H
H
H
F
O
—CH2CH═CMe2


I-2047
NMe2
H
H
H
H
F
OMe
OMe
OH
H
H
H
F
O
—(CH2)2CH═CMe2


I-2048
NMe2
H
H
H
H
F
OMe
OMe
OH
H
H
H
F
O
—CH2CH═CCl2


I-2049
NMe2
H
H
H
H
F
OMe
OMe
OH
H
H
H
F
O
—CH2C≡CMe


I-2050
NMe2
H
H
H
H
F
OMe
OMe
OH
H
H
H
F
O
—CH2C6H4-4-Me


I-2051
COOH
H
H
H
H
H
OMe
OMe
OH
H
H
H
OH
O
—(CH2)2CH═CMe2


I-2052
COOH
H
H
H
H
H
OMe
OMe
OH
H
H
H
OH
O
—CH2CH═CCl2


I-2053
COOH
H
H
H
H
H
OMe
OMe
OH
H
H
H
OH
O
—CH2C≡CMe


I-2054
COOH
H
H
H
H
H
OMe
OMe
OH
H
H
H
OMs
O
—CH2CH═CMe2


I-2055
COOH
H
H
H
H
H
OMe
OMe
OH
H
H
H
OMs
O
—(CH2)2CH═CMe2


I-2056
COOH
H
H
H
H
H
OMe
OMe
OH
H
H
H
OMs
O
—CH2CH═CCl2


I-2057
COOH
H
H
H
H
H
OMe
OMe
OH
H
H
H
OMs
O
—CH2C≡CMe


I-2058
COOH
H
H
H
H
H
OMe
OMe
OH
H
H
H
OMs
O
—CH2C6H4-4-Me


I-2059
COOH
H
H
H
H
H
OMe
OMe
OH
H
H
H
COOH
O
—CH2CH═CMe2


I-2060
COOH
H
H
H
H
H
OMe
OMe
OH
H
H
H
COOH
O
—(CH2)2CH═CMe2


I-2061
COON
H
H
H
H
H
OMe
OMe
OH
H
H
H
COOH
O
—CH2CH═CCl2































TABLE 303







I-2062
COOH
H
H
H
H
H
OMe
OMe
OH
H
H
H
COOH
O
—CH2C≡CMe


I-2063
COOH
H
H
H
H
H
OMe
OMe
OH
H
H
H
COOH
O
—CH2C6H4-4-Me


I-2064
COOH
H
H
H
H
H
OMe
OMe
OH
H
H
H
CH2OH
O
—CH2CH═CMe2


I-2065
COOH
H
H
H
H
H
OMe
OMe
OH
H
H
H
CH2OH
O
—(CH2)2CH═CMe2


I-2066
COOH
H
H
H
H
H
OMe
OMe
OH
H
H
H
CH2OH
O
—CH2CH═CCl2


I-2067
COOH
H
H
H
H
H
OMe
OMe
OH
H
H
H
CH2OH
O
—CH2C≡CMe


I-2068
COOH
H
H
H
H
H
OMe
OMe
OH
H
H
H
CH2OH
O
—CH2C6H4-4-Me


I-2069
COOH
H
H
H
H
H
OMe
OMe
OH
H
H
H
F
O
—CH2CH═CMe2


I-2070
COOH
H
H
H
H
H
OMe
OMe
OH
H
H
H
F
O
—(CH2)2CH═CMe2


I-2071
COOH
H
H
H
H
H
OMe
OMe
OH
H
H
H
F
O
—CH2CH═CCl2


I-2072
COOH
H
H
H
H
H
OMe
OMe
OH
H
H
H
F
O
—CH2C≡CMe


I-2073
COOH
H
H
H
H
H
OMe
OMe
OH
H
H
H
F
O
—CH2C6H4-4-Me


I-2074
COOH
H
H
H
H
H
OMe
OMe
COOH
H
H
H
OH
O
—CH2CH═CMe2


I-2075
COOH
H
H
H
H
H
OMe
OMe
COOH
H
H
H
OH
O
—(CH2)2CH═CMe2


I-2076
COOH
H
H
H
H
H
OMe
OMe
COOH
H
H
H
OH
O
—CH2CH═CCl2


I-2077
COOH
H
H
H
H
H
OMe
OMe
COOH
H
H
H
OH
O
—CH2C≡CMe


I-2078
COOH
H
H
H
H
H
OMe
OMe
COOH
H
H
H
OH
O
—CH2C6H4-4-Me


I-2079
COOH
H
H
H
H
H
OMe
OMe
COOH
H
H
H
OMs
O
—CH2CH═CMe2


I-2080
COOH
H
H
H
H
H
OMe
OMe
COOH
H
H
H
OMs
O
—(CH2)2CH═CMe2


I-2081
COOH
H
H
H
H
H
OMe
OMe
COOH
H
H
H
OMs
O
—CH2CH═CCl2


I-2082
COOH
H
H
H
H
H
OMe
OMe
COOH
H
H
H
OMs
O
—CH2C≡CMe































TABLE 304







I-2083
COOH
H
H
H
H
H
OMe
OMe
COOH
H
H
H
OMs
O
—CH2C6H4-4-Me


I-2084
COOH
H
H
H
H
H
OMe
OMe
COOH
H
H
H
COOH
O
—CH2CH═CMe2


I-2085
COOH
H
H
H
H
H
OMe
OMe
COOH
H
H
H
COOH
O
—(CH2)2CH═CMe2


I-2086
COOH
H
H
H
H
H
OMe
OMe
COOH
H
H
H
COOH
O
—CH2CH═CCl2


I-2087
COOH
H
H
H
H
H
OMe
OMe
COOH
H
H
H
COOH
O
—CH2C≡CMe


I-2088
COOH
H
H
H
H
H
OMe
OMe
COOH
H
H
H
COOH
O
—CH2C6H4-4-Me


I-2089
COOH
H
H
H
H
H
OMe
OMe
COOH
H
H
H
CH2OH
O
—CH2CH═CMe2


I-2090
COOH
H
H
H
H
H
OMe
OMe
COOH
H
H
H
CH2OH
O
—(CH2)2CH═CMe2


I-2091
COOH
H
H
H
H
H
OMe
OMe
COOH
H
H
H
CH2OH
O
—CH2CH═CCl2


I-2092
COOH
H
H
H
H
H
OMe
OMe
COOH
H
H
H
CH2OH
O
—CH2C≡CMe


I-2093
COOH
H
H
H
H
H
OMe
OMe
COOH
H
H
H
CH2OH
O
—CH2C6H4-4-Me


I-2094
COOH
H
H
H
H
H
OMe
OMe
COOH
H
H
H
F
O
—CH2CH═CMe2


I-2095
COOH
H
H
H
H
H
OMe
OMe
COOH
H
H
H
F
O
—(CH2)2CH═CMe2


I-2096
COOH
H
H
H
H
H
OMe
OMe
COOH
H
H
H
F
O
—CH2CH═CCl2


I-2097
COOH
H
H
H
H
H
OMe
OMe
COOH
H
H
H
F
O
—CH2C≡CMe


I-2098
COOH
H
H
H
H
H
OMe
OMe
COOH
H
H
H
F
O
—CH2C6H4-4-Me


I-2099
COOH
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
OH
O
—CH2CH═CMe2


I-2100
COOH
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
OH
O
—(CH2)2CH═CMe2


I-2101
COOH
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
OH
O
—CH2CH═CCl2


I-2102
COOH
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
OH
O
—CH2C≡CMe


I-2103
COOH
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
OH
O
—CH2C6H4-4-Me































TABLE 305







I-2104
COOH
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
OMs
O
—CH2CH═CMe2


I-2105
COOH
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
OMs
O
—(CH2)2CH═CMe2


I-2106
COOH
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
OMs
O
—CH2CH═CCl2


I-2107
COOH
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
OMs
O
—CH2C≡CMe


I-2108
COOH
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
OMs
O
—CH2C6H4-4-Me


I-2109
COOH
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
COOH
O
—CH2CH═CMe2


I-2110
COOH
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
COOH
O
—(CH2)2CH═CMe2


I-2111
COOH
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
COOH
O
—CH2CH═CCl2


I-2112
COOH
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
COOH
O
—CH2C≡CMe


I-2113
COOH
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
COOH
O
—CH2C6H4-4-Me


I-2114
COOH
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
CH2OH
O
—CH2CH═CMe2


I-2115
COOH
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
CH2OH
O
—(CH2)2CH═CMe2


I-2116
COOH
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
CH2OH
O
—CH2CH═CCl2


I-2117
COOH
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
CH2OH
O
—CH2C≡CMe


I-2118
COOH
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
CH2OH
O
—CH2C6H4-4-Me


I-2119
COOH
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
F
O
—CH2CH═CMe2


I-2120
COOH
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
F
O
—(CH2)2CH═CMe2


I-2121
COOH
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
F
O
—CH2CH═CCl2


I-2122
COOH
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
F
O
—CH2C≡CMe


I-2123
COOH
H
H
H
H
H
OMe
OMe
CH2OH
H
H
H
F
O
—CH2C6H4-4-Me


I-2124
COOH
H
H
H
H
H
OMe
OMe
Me
H
H
H
OH
O
—CH2CH═CMe2































TABLE 306







I-2125
COOH
H
H
H
H
H
OMe
OMe
Me
H
H
H
OH
O
—(CH2)2CH═CMe2


I-2126
COOH
H
H
H
H
H
OMe
OMe
Me
H
H
H
OH
O
—CH2CH═CCl2


I-2127
COOH
H
H
H
H
H
OMe
OMe
Me
H
H
H
OH
O
—CH2C≡CMe


I-2128
COOH
H
H
H
H
H
OMe
OMe
Me
H
H
H
OH
O
—CH2C6H4-4-Me


I-2129
COOH
H
H
H
H
H
OMe
OMe
Me
H
H
H
OMs
O
—CH2CH═CMe2


I-2130
COOH
H
H
H
H
H
OMe
OMe
Me
H
H
H
OMs
O
—(CH2)2CH═CMe2


I-2131
COOH
H
H
H
H
H
OMe
OMe
Me
H
H
H
OMs
O
—CH2CH═CCl2


I-2132
COOH
H
H
H
H
H
OMe
OMe
Me
H
H
H
OMs
O
—CH2C≡CMe


I-2133
COOH
H
H
H
H
H
OMe
OMe
Me
H
H
H
OMs
O
—CH2C6H4-4-Me


I-2134
COOH
H
H
H
H
H
OMe
OMe
Me
H
H
H
COOH
O
—CH2CH═CMe2


I-2135
COOH
H
H
H
H
H
OMe
OMe
Me
H
H
H
COOH
O
—(CH2)2CH═CMe2


I-2136
COOH
H
H
H
H
H
OMe
OMe
Me
H
H
H
COOH
O
—CH2CH═CCl2


I-2137
COOH
H
H
H
H
H
OMe
OMe
Me
H
H
H
COOH
O
—CH2C≡CMe


I-2138
COOH
H
H
H
H
H
OMe
OMe
Me
H
H
H
COOH
O
—CH2C6H4-4-Me


I-2139
COOH
H
H
H
H
H
OMe
OMe
Me
H
H
H
CH2OH
O
—CH2CH═CMe2


I-2140
COOH
H
H
H
H
H
OMe
OMe
Me
H
H
H
CH2OH
O
—(CH2)2CH═CMe2


I-2141
COOH
H
H
H
H
H
OMe
OMe
Me
H
H
H
CH2OH
O
—CH2CH═CCl2


I-2142
COOH
H
H
H
H
H
OMe
OMe
Me
H
H
H
CH2OH
O
—CH2C≡CMe


I-2143
COOH
H
H
H
H
H
OMe
OMe
Me
H
H
H
CH2OH
O
—CH2C6H4-4-Me


I-2144
COOH
H
H
H
H
H
OMe
OMe
Me
H
H
H
F
O
—CH2CH═CMe2


I-2145
COOH
H
H
H
H
H
OMe
OMe
Me
H
H
H
F
O
—(CH2)2CH═CMe2































TABLE 307







I-2146
COOH
H
H
H
H
H
OMe
OMe
Me
H
H
H
F
O
—CH2CH═CCl2


I-2147
COOH
H
H
H
H
H
OMe
OMe
Me
H
H
H
F
O
—CH2C≡CMe


I-2148
COOH
H
H
H
H
H
OMe
OMe
Me
H
H
H
F
O
—CH2C6H4-4-Me


I-2149
COOH
H
H
H
H
H
OMe
OMe
H
H
H
H
OH
O
—CH2CH═CMe2


I-2150
COOH
H
H
H
H
H
OMe
OMe
H
H
H
H
OH
O
—(CH2)2CH═CMe2


I-2151
COOH
H
H
H
H
H
OMe
OMe
H
H
H
H
OH
O
—CH2CH═CCl2


I-2152
COOH
H
H
H
H
H
OMe
OMe
H
H
H
H
OH
O
—CH2C≡CMe


I-2153
COOH
H
H
H
H
H
OMe
OMe
H
H
H
H
OH
O
—CH2C6H4-4-Me


I-2154
COOH
H
H
H
H
H
OMe
OMe
H
H
H
H
OMs
O
—CH2CH═CMe2


I-2155
COOH
H
H
H
H
H
OMe
OMe
H
H
H
H
OMs
O
—(CH2)2CH═CMe2


I-2156
COOH
H
H
H
H
H
OMe
OMe
H
H
H
H
OMs
O
—CH2CH═CCl2


I-2157
COOH
H
H
H
H
H
OMe
OMe
H
H
H
H
OMs
O
—CH2C≡CMe


I-2158
COOH
H
H
H
H
H
OMe
OMe
H
H
H
H
OMs
O
—CH2C6H4-4-Me


I-2159
COOH
H
H
H
H
H
OMe
OMe
H
H
H
H
COOH
O
—CH2CH═CMe2


I-2160
COOH
H
H
H
H
H
OMe
OMe
H
H
H
H
COOH
O
—(CH2)2CH═CMe2


I-2161
COOH
H
H
H
H
H
OMe
OMe
H
H
H
H
COOH
O
—CH2CH═CCl2


I-2162
COOH
H
H
H
H
H
OMe
OMe
H
H
H
H
COOH
O
—CH2C≡CMe


I-2163
COOH
H
H
H
H
H
OMe
OMe
H
H
H
H
COOH
O
—CH2C6H4-4-Me


I-2164
COOH
H
H
H
H
H
OMe
OMe
H
H
H
H
CH2OH
O
—CH2CH═CMe2


I-2165
COOH
H
H
H
H
H
OMe
OMe
H
H
H
H
CH2OH
O
—(CH2)2CH═CMe2


I-2166
COOH
H
H
H
H
H
OMe
OMe
H
H
H
H
CH2OH
O
—CH2CH═CCl2































TABLE 308







I-2167
COOH
H
H
H
H
H
OMe
OMe
H
H
H
H
CH2OH
O
—CH2C≡CMe


I-2168
COOH
H
H
H
H
H
OMe
OMe
H
H
H
H
CH2OH
O
—CH2C6H4-4-Me


I-2169
COOH
H
H
H
H
H
OMe
OMe
H
H
H
H
F
O
—CH2CH═CMe2


I-2170
COOH
H
H
H
H
H
OMe
OMe
H
H
H
H
F
O
—(CH2)2CH═CMe2


I-2171
COOH
H
H
H
H
H
OMe
OMe
H
H
H
H
F
O
—CH2CH═CCl2


I-2172
COOH
H
H
H
H
H
OMe
OMe
H
H
H
H
F
O
—CH2C≡CMe


I-2173
COOH
H
H
H
H
H
OMe
OMe
H
H
H
H
F
O
—CH2C6H4-4-Me


I-2174
COOH
H
H
H
H
F
OMe
OMe
OH
H
H
H
OH
O
—CH2CH═CMe2


I-2175
COOH
H
H
H
H
F
OMe
OMe
OH
H
H
H
OH
O
—(CH2)2CH═CMe2


I-2176
COOH
H
H
H
H
F
OMe
OMe
OH
H
H
H
OH
O
—CH2CH═CCl2


I-2177
COOH
H
H
H
H
F
OMe
OMe
OH
H
H
H
OH
O
—CH2C≡CMe


I-2178
COOH
H
H
H
H
F
OMe
OMe
OH
H
H
H
OH
O
—CH2C6H4-4-Me


I-2179
COOH
H
H
H
H
F
OMe
OMe
OH
H
H
H
OMs
O
—CH2CH═CMe2


I-2180
COOH
H
H
H
H
F
OMe
OMe
OH
H
H
H
OMs
O
—(CH2)2CH═CMe2


I-2181
COOH
H
H
H
H
F
OMe
OMe
OH
H
H
H
OMs
O
—CH2CH═CCl2


I-2182
COOH
H
H
H
H
F
OMe
OMe
OH
H
H
H
OMs
O
—CH2C≡CMe


I-2183
COOH
H
H
H
H
F
OMe
OMe
OH
H
H
H
OMs
O
—CH2C6H4-4-Me


I-2184
COOH
H
H
H
H
F
OMe
OMe
OH
H
H
H
COOH
O
—CH2CH═CMe2


I-2185
COOH
H
H
H
H
F
OMe
OMe
OH
H
H
H
COOH
O
—(CH2)2CH═CMe2


I-2186
COOH
H
H
H
H
F
OMe
OMe
OH
H
H
H
COOH
O
—CH2CH═CCl2


I-2187
COOH
H
H
H
H
F
OMe
OMe
OH
H
H
H
COOH
O
—CH2C≡CMe































TABLE 309







I-2188
COOH
H
H
H
H
F
OMe
OMe
OH
H
H
H
COOH
O
—CH2C6H4-4-Me


I-2189
COOH
H
H
H
H
F
OMe
OMe
OH
H
H
H
CH2OH
O
—CH2CH═CMe2


I-2190
COOH
H
H
H
H
F
OMe
OMe
OH
H
H
H
CH2OH
O
—(CH2)2CH═CMe2


I-2191
COOH
H
H
H
H
F
OMe
OMe
OH
H
H
H
CH2OH
O
—CH2CH═CCl2


I-2192
COOH
H
H
H
H
F
OMe
OMe
OH
H
H
H
CH2OH
O
—CH2C≡CMe


I-2193
COOH
H
H
H
H
F
OMe
OMe
OH
H
H
H
CH2OH
O
—CH2C6H4-4-Me


I-2194
COOH
H
H
H
H
F
OMe
OMe
OH
H
H
H
F
O
—CH2CH═CMe2


I-2195
COOH
H
H
H
H
F
OMe
OMe
OH
H
H
H
F
O
—(CH2)2CH═CMe2


I-2196
COOH
H
H
H
H
F
OMe
OMe
OH
H
H
H
F
O
—CH2CH═CCl2


I-2197
COOH
H
H
H
H
F
OMe
OMe
OH
H
H
H
F
O
—CH2C≡CMe


I-2198
COOH
H
H
H
H
F
OMe
OMe
OH
H
H
H
F
O
—CH2C6H4-4-Me


I-2199
NO2
H
H
H
H
H
OMe
OMe
H
H
H
H
OMs
O
—(CH2)2CH═CMe2


I-2200
OMs
NO2
H
H
H
H
OMe
OMe
H
H
H
H
OMs
O
—(CH2)2CH═CMe2


I-2201
OMs
H
H
H
H
H
OMe
OMe
H
NO2
H
H
OMs
O
—(CH2)2CH═CMe2


I-2202
CN
H
H
H
H
H
OMe
OMe
H
H
H
H
OMs
O
—(CH2)2CH═CMe2


I-2203
OMs
CN
H
H
H
H
OMe
OMe
H
H
H
H
OMs
O
—(CH2)2CH═CMe2


I-2204
OH
H
H
H
H
H
OMe
OMe
OMs
H
H
H
OH
O
—CH2CH═CMe2


I-2205
OH
H
H
H
H
H
OMe
OMe
OMs
H
H
H
OH
O
—CH2C6H5


I-2206
OH
H
H
H
H
H
OMe
OMe
OMs
H
H
H
NH2
O
—CH2CH═CMe2


I-2207
OH
H
H
H
H
H
OMe
OMe
OMs
H
H
H
NH2
O
—CH2C6H5


I-2208
OH
H
H
H
H
H
OMe
OEt
OH
H
H
H
OH
O
—CH2C6H5































TABLE 310







I-2209
OH
H
H
H
H
H
OMe
OEt
OH
H
H
H
NH2
O
—CH2CH═CMe2


I-2210
OH
H
H
H
H
H
Me
Me
H
H
H
H
OH
O
—CH2C6H5


I-2211
OH
H
H
H
H
H
Me
Me
H
H
H
H
NH2
O
—CH2CH═CMe2


I-2212
OH
H
H
H
H
H
Me
Me
H
H
H
H
NH2
O
—CH2C6H5


I-2213
OH
H
H
H
H
H
OMe
OMe
NH2
H
H
H
OH
O
—CH2CH═CMe2


I-2214
OH
H
H
H
H
H
OMe
OMe
NH2
H
H
H
NH2
O
—CH2CH═CMe2


I-2215
OH
H
H
H
H
H
OMe
OMe
NH2
H
H
H
NH2
O
—CH2C6H5


I-2216
OH
H
H
H
H
H
OMe
OMe
OH
H
H
H
OH
O
—CH2CH═CMe2


I-2217
OH
H
H
H
H
H
OMe
OMe
OH
H
H
H
OH
O
—CH2C6H5


I-2218
OH
H
H
H
H
H
OMe
OMe
OH
H
H
H
NH2
O
—CH2CH═CMe2


I-2219
OH
H
H
H
H
H
OMe
OMe
OH
H
H
H
NH2
O
—CH2C6H5


I-2220
OMs
H
H
H
H
H
OMe
OMe
OMs
H
H
H
OH
O
—CH2CH═CMe2


I-2221
OMs
H
H
H
H
H
OMe
OMe
OMs
H
H
H
OH
O
—CH2C6H5


I-2222
OMs
H
H
H
H
H
OMe
OMe
OMs
H
H
H
NH2
O
—CH2CH═CMe2


I-2223
OMs
H
H
H
H
H
OMe
OMe
OMs
H
H
H
NH2
O
—CH2C6H5


I-2224
OMs
H
H
H
H
H
OMe
OEt
OH
H
H
H
OH
O
—CH2CH═CMe2


I-2225
OMs
H
H
H
H
H
OMe
OEt
OH
H
H
H
OH
O
—CH2C6H5


I-2226
OMs
H
H
H
H
H
OMe
OEt
OH
H
H
H
NH2
O
—CH2CH═CMe2


I-2227
OMs
H
H
H
H
H
OMe
OEt
OH
H
H
H
NH2
O
—CH2C6H5


I-2228
OMs
H
H
H
H
H
Me
Me
H
H
H
H
OH
O
—CH2CH═CMe2


I-2229
OMs
H
H
H
H
H
Me
Me
H
H
H
H
OH
O
—CH2C6H5































TABLE 311







I-2230
OMs
H
H
H
H
H
Me
Me
H
H
H
H
NH2
O
—CH2CH═CMe2


I-2231
OMs
H
H
H
H
H
Me
Me
H
H
H
H
NH2
O
—CH2C6H5


I-2232
OMs
H
H
H
H
H
OMe
OMe
NH2
H
H
H
OH
O
—CH2CH═CMe2


I-2233
OMs
H
H
H
H
H
OMe
OMe
NH2
H
H
H
NH2
O
—CH2CH═CMe2


I-2234
OMs
H
H
H
H
H
OMe
OMe
NH2
H
H
H
NH2
O
—CH2C6H5


I-2235
OMs
H
H
H
H
H
OMe
OMe
OH
H
H
H
OH
O
—CH2CH═CMe2


I-2236
OMs
H
H
H
H
H
OMe
OMe
OH
H
H
H
OH
O
—CH2C6H5


I-2237
OMs
H
H
H
H
H
OMe
OMe
OH
H
H
H
NH2
O
—CH2CH═CMe2


I-2238
OMs
H
H
H
H
H
OMe
OMe
OH
H
H
H
NH2
O
—CH2C6H5


I-2239
CF3
H
H
H
H
H
OMe
OMe
OMs
H
H
H
OH
O
—CH2CH═CMe2


I-2240
CF3
H
H
H
H
H
OMe
OMe
OMs
H
H
H
OH
O
—CH2C6H5


I-2241
CF3
H
H
H
H
H
OMe
OMe
OMs
H
H
H
NH2
O
—CH2CH═CMe2


I-2242
CF3
H
H
H
H
H
OMe
OMe
OMs
H
H
H
NH2
O
—CH2C6H5


I-2243
CF3
H
H
H
H
H
OMe
OEt
OH
H
H
H
OH
O
—CH2CH═CMe2


I-2244
CF3
H
H
H
H
H
OMe
OEt
OH
H
H
H
OH
O
—CH2C6H5


I-2245
CF3
H
H
H
H
H
OMe
OEt
OH
H
H
H
NH2
O
—CH2CH═CMe2


I-2246
CF3
H
H
H
H
H
OMe
OEt
OH
H
H
H
NH2
O
—CH2C6H5


I-2247
CF3
H
H
H
H
H
Me
Me
H
H
H
H
OH
O
—CH2CH═CMe2


I-2248
CF3
H
H
H
H
H
Me
Me
H
H
H
H
OH
O
—CH2C6H5


I-2249
CF3
H
H
H
H
H
Me
Me
H
H
H
H
NH2
O
—CH2CH═CMe2


I-2250
CF3
H
H
H
H
H
Me
Me
H
H
H
H
NH2
O
—CH2C6H5































TABLE 312







I-2251
CF3
H
H
H
H
H
OMe
OMe
NH2
H
H
H
OH
O
—CH2CH═CMe2


I-2252
CF3
H
H
H
H
H
OMe
OMe
NH2
H
H
H
OH
O
—CH2C6H5


I-2253
CF3
H
H
H
H
H
OMe
OMe
NH2
H
H
H
NH2
O
—CH2CH═CMe2


I-2254
CF3
H
H
H
H
H
OMe
OMe
NH2
H
H
H
NH2
O
—CH2C6H5


I-2255
CF3
H
H
H
H
H
OMe
OMe
OH
H
H
H
OH
O
—CH2CH═CMe2


I-2256
CF3
H
H
H
H
H
OMe
OMe
OH
H
H
H
OH
O
—CH2C6H5


I-2257
CF3
H
H
H
H
H
OMe
OMe
OH
H
H
H
NH2
O
—CH2CH═CMe2


I-2258
CF3
H
H
H
H
H
OMe
OMe
OH
H
H
H
NH2
O
—CH2C6H5


I-2259
NH2
H
H
H
H
H
OMe
OMe
OMs
H
H
H
OH
O
—CH2CH═CMe2


I-2260
NH2
H
H
H
H
H
OMe
OMe
OMs
H
H
H
OH
O
—CH2C6H5


I-2261
NH2
H
H
H
H
H
OMe
OMe
OMs
H
H
H
NH2
O
—CH2CH═CMe2


I-2262
NH2
H
H
H
H
H
OMe
OMe
OMs
H
H
H
NH2
O
—CH2C6H5


I-2263
NH2
H
H
H
H
H
OMe
OEt
OH
H
H
H
OH
O
—CH2CH═CMe2


I-2264
NH2
H
H
H
H
H
OMe
OEt
OH
H
H
H
OH
O
—CH2C6H5


I-2265
NH2
H
H
H
H
H
OMe
OEt
OH
H
H
H
NH2
O
—CH2CH═CMe2


I-2266
NH2
H
H
H
H
H
OMe
OEt
OH
H
H
H
NH2
O
—CH2C6H5


I-2267
NH2
H
H
H
H
H
Me
Me
H
H
H
H
OH
O
—CH2CH═CMe2


I-2268
NH2
H
H
H
H
H
Me
Me
H
H
H
H
OH
O
—CH2C6H5


I-2269
NH2
H
H
H
H
H
Me
Me
H
H
H
H
NH2
O
—CH2CH═CMe2


I-2270
NH2
H
H
H
H
H
Me
Me
H
H
H
H
NH2
O
—CH2C6H5


I-2271
NH2
H
H
H
H
H
OMe
OMe
NH2
H
H
H
OH
O
—CH2CH═CMe2































TABLE 313







I-2272
NH2
H
H
H
H
H
OMe
OMe
NH2
H
H
H
OH
O
—CH2C6H5


I-2273
NH2
H
H
H
H
H
OMe
OMe
NH2
H
H
H
NH2
O
—CH2CH═CMe2


I-2274
NH2
H
H
H
H
H
OMe
OMe
NH2
H
H
H
NH2
O
—CH2C6H5


I-2275
NH2
H
H
H
H
H
OMe
OMe
OH
H
H
H
OH
O
—CH2CH═CMe2


I-2276
NH2
H
H
H
H
H
OMe
OMe
OH
H
H
H
OH
O
—CH2C6H5


I-2277
NH2
H
H
H
H
H
OMe
OMe
OH
H
H
H
NH2
O
—CH2CH═CMe2


I-2278
NH2
H
H
H
H
H
OMe
OMe
OH
H
H
H
NH2
O
—CH2C6H5


I-2279
—NHCH2CH═CMe2
H
F
H
H
Me
Me
Me
H
H
H
H
OMe
NH
—CH2CH═CMe2


I-2280
—NHCH2CH═CMe2
H
F
H
H
Me
Me
Me
H
H
H
H
OMe
NH
—(CH2)2CHMe2


I-2281
—NHCH2CH═CMe2
H
F
H
H
Me
Me
Me
H
H
H
H
OMe
NMe
Me


I-2282
—NHCH2CH═CMe2
H
F
H
H
Me
Me
Me
H
H
H
H
OMe
O
—CH2CH═CMe2


I-2283
—NHCH2CH═CMe2
H
F
H
H
Me
Me
Me
H
H
H
H
OMe
O
—CH2CH═CCl2


I-2284
—NHCH2CH═CMe2
H
F
H
H
Me
Me
Me
H
H
H
F
H
NH
—CH2CH═CMe2


I-2285
—NHCH2CH═CMe2
H
F
H
H
Me
Me
Me
H
H
H
F
H
NH
—(CH2)2CHMe2


I-2286
—NHCH2CH═CMe2
H
F
H
H
Me
Me
Me
H
H
H
F
H
NMe
Me


I-2287
—NHCH2CH═CMe2
H
F
H
H
Me
Me
Me
H
H
H
F
H
O
—CH2CH═CMe2


I-2288
—NHCH2CH═CMe2
H
F
H
H
Me
Me
Me
H
H
H
F
H
O
—CH2CH═CCl2


I-2289
—NHCH2CH═CMe2
H
F
H
H
Me
Me
Me
H
H
H
H
OEt
NH
—CH2CH═CMe2


I-2290
—NHCH2CH═CMe2
H
F
H
H
Me
Me
Me
H
H
H
H
OEt
NH
—(CH2)2CHMe2


I-2291
—NHCH2CH═CMe2
H
F
H
H
Me
Me
Me
H
H
H
H
OEt
NMe
Me


I-2292
—NHCH2CH═CMe2
H
F
H
H
Me
Me
Me
H
H
H
H
OEt
O
—CH2CH═CMe2































TABLE 314







I-2293
—NHCH2CH═CMe2
H
F
H
H
Me
Me
Me
H
H
H
H
OEt
O
—CH2CH═CCl2


I-2294
—NHCH2CH═CMe2
H
F
H
H
H
Me
OMe
OH
H
H
H
OMe
NH
—CH2CH═CMe2


I-2295
—NHCH2CH═CMe2
H
F
H
H
H
Me
OMe
OH
H
H
H
OMe
NH
—(CH2)2CHMe2


I-2296
—NHCH2CH═CMe2
H
F
H
H
H
Me
OMe
OH
H
H
H
OMe
NMe
Me


I-2297
—NHCH2CH═CMe2
H
F
H
H
H
Me
OMe
OH
H
H
H
OMe
O
—CH2CH═CMe2


I-2298
—NHCH2CH═CMe2
H
F
H
H
H
Me
OMe
OH
H
H
H
OMe
O
—CH2CH═CCl2


I-2299
—NHCH2CH═CMe2
H
F
H
H
H
Me
OMe
OH
H
H
F
H
NH
—CH2CH═CMe2


I-2300
—NHCH2CH═CMe2
H
F
H
H
H
Me
OMe
OH
H
H
F
H
NH
—(CH2)2CHMe2


I-2301
—NHCH2CH═CMe2
H
F
H
H
H
Me
OMe
OH
H
H
F
H
NMe
Me


I-2302
—NHCH2CH═CMe2
H
F
H
H
H
Me
OMe
OH
H
H
F
H
O
—CH2CH═CMe2


I-2303
—NHCH2CH═CMe2
H
F
H
H
H
Me
OMe
OH
H
H
F
H
O
—CH2CH═CCl2


I-2304
—NHCH2CH═CMe2
H
F
H
H
H
Me
OMe
OH
H
H
H
OEt
NH
—CH2CH═CMe2


I-2305
—NHCH2CH═CMe2
H
F
H
H
H
Me
OMe
OH
H
H
H
OEt
NH
—(CH2)2CHMe2


I-2306
—NHCH2CH═CMe2
H
F
H
H
H
Me
OMe
OH
H
H
H
OEt
NMe
Me


I-2307
—NHCH2CH═CMe2
H
F
H
H
H
Me
OMe
OH
H
H
H
OEt
O
—CH2CH═CMe2


I-2308
—NHCH2CH═CMe2
H
F
H
H
H
Me
OMe
OH
H
H
H
OEt
O
—CH2CH═CCl2


I-2309
—NHCH2CH═CMe2
H
F
H
H
Me
H
Me
OH
H
H
H
OMe
NH
—CH2CH═CMe2


I-2330
—NHCH2CH═CMe2
H
F
H
H
Me
H
Me
OH
H
H
H
OMe
NH
—(CH2)2CHMe2


I-2331
—NHCH2CH═CMe2
H
F
H
H
Me
H
Me
OH
H
H
H
OMe
NMe
Me


I-2332
—NHCH2CH═CMe2
H
F
H
H
Me
H
Me
OH
H
H
H
OMe
O
—CH2CH═CMe2


I-2333
—NHCH2CH═CMe2
H
F
H
H
Me
H
Me
OH
H
H
H
OMe
O
—CH2CH═CCl2































TABLE 315







I-2334
—NHCH2CH═CMe2
H
F
H
H
Me
H
Me
OH
H
H
F
H
NH
—CH2CH═CMe2


I-2335
—NHCH2CH═CMe2
H
F
H
H
Me
H
Me
OH
H
H
F
H
NH
—(CH2)2CHMe2


I-2336
—NHCH2CH═CMe2
H
F
H
H
Me
H
Me
OH
H
H
F
H
NMe
Me


I-2337
—NHCH2CH═CMe2
H
F
H
H
Me
H
Me
OH
H
H
F
H
O
—CH2CH═CMe2


I-2338
—NHCH2CH═CMe2
H
F
H
H
Me
H
Me
OH
H
H
F
H
O
—CH2CH═CCl2


I-2339
—NHCH2CH═CMe2
H
F
H
H
Me
H
Me
OH
H
H
H
OEt
NH
—CH2CH═CMe2


I-2340
—NHCH2CH═CMe2
H
F
H
H
Me
H
Me
OH
H
H
H
OEt
NH
—(CH2)2CHMe2


I-2341
—NHCH2CH═CMe2
H
F
H
H
Me
H
Me
OH
H
H
H
OEt
NMe
Me


I-2342
—NHCH2CH═CMe2
H
F
H
H
Me
H
Me
OH
H
H
H
OEt
O
—CH2CH═CMe2


I-2343
—NHCH2CH═CMe2
H
F
H
H
Me
H
Me
OH
H
H
H
OEt
O
—CH2CH═CCl2


I-2344
—NHCH2CH═CMe2
H
F
H
H
H
Me
Me
Me
H
H
H
OMe
NH
—CH2CH═CMe2


I-2345
—NHCH2CH═CMe2
H
F
H
H
H
Me
Me
Me
H
H
H
OMe
NH
—(CH2)2CHMe2


I-2346
—NHCH2CH═CMe2
H
F
H
H
H
Me
Me
Me
H
H
H
OMe
NMe
Me


I-2347
—NHCH2CH═CMe2
H
F
H
H
H
Me
Me
Me
H
H
H
OMe
O
—CH2CH═CMe2


I-2348
—NHCH2CH═CMe2
H
F
H
H
H
Me
Me
Me
H
H
H
OMe
O
—CH2CH═CCl2


I-2349
—NHCH2CH═CMe2
H
F
H
H
H
Me
Me
Me
H
H
F
H
NH
—CH2CH═CMe2


I-2350
—NHCH2CH═CMe2
H
F
H
H
H
Me
Me
Me
H
H
F
H
NH
—(CH2)2CHMe2


I-2351
—NHCH2CH═CMe2
H
F
H
H
H
Me
Me
Me
H
H
F
H
NMe
Me


I-2352
—NHCH2CH═CMe2
H
F
H
H
H
Me
Me
Me
H
H
F
H
O
—CH2CH═CMe2


I-2353
—NHCH2CH═CMe2
H
F
H
H
H
Me
Me
Me
H
H
F
H
O
—CH2CH═CCl2


I-2354
—NHCH2CH═CMe2
H
F
H
H
H
Me
Me
Me
H
H
H
OEt
NH
—CH2CH═CMe2































TABLE 316







I-2355
—NHCH2CH═CMe2
H
F
H
H
H
Me
Me
Me
H
H
H
OEt
NH
—(CH2)2CHMe2


I-2356
—NHCH2CH═CMe2
H
F
H
H
H
Me
Me
Me
H
H
H
OEt
NMe
Me


I-2357
—NHCH2CH═CMe2
H
F
H
H
H
Me
Me
Me
H
H
H
OEt
O
—CH2CH═Me2


I-2358
—NHCH2CH═CMe2
H
F
H
H
H
Me
Me
Me
H
H
H
OEt
O
—CH2CH═CCl2


I-2359
—NHCH2CH═CMe2
H
F
H
H
H
OMe
OEt
OH
H
H
H
OMe
NH
—CH2CH═CMe2


I-2360
—NHCH2CH═CMe2
H
F
H
H
H
OMe
OEt
OH
H
H
H
OMe
NH
—(CH2)2CHMe2


I-2361
—NHCH2CH═CMe2
H
F
H
H
H
OMe
OEt
OH
H
H
H
OMe
NMe
Me


I-2362
—NHCH2CH═CMe2
H
F
H
H
H
OMe
OEt
OH
H
H
H
OMe
O
—CH2CH═CMe2


I-2363
—NHCH2CH═CMe2
H
F
H
H
H
OMe
OEt
OH
H
H
H
OMe
O
—CH2CH═CCl2


I-2364
—NHCH2CH═CMe2
H
F
H
H
H
OMe
OEt
OH
H
H
F
H
NH
—CH2CH═CMe2


I-2365
—NHCH2CH═CMe2
H
F
H
H
H
OMe
OEt
OH
H
H
F
H
NH
—(CH2)2CHMe2


I-2366
—NHCH2CH═CMe2
H
F
H
H
H
OMe
OEt
OH
H
H
F
H
NMe
Me


I-2367
—NHCH2CH═CMe2
H
F
H
H
H
OMe
OEt
OH
H
H
F
H
O
—CH2CH═CMe2


I-2368
—NHCH2CH═CMe2
H
F
H
H
H
OMe
OEt
OH
H
H
F
H
O
—CH2CH═CCl2


I-2369
—NHCH2CH═CMe2
H
F
H
H
H
OMe
OEt
OH
H
H
H
OEt
NH
—CH2CH═CMe2


I-2370
—NHCH2CH═CMe2
H
F
H
H
H
OMe
OEt
OH
H
H
H
OEt
NH
—(CH2)2CHMe2


I-2371
—NHCH2CH═CMe2
H
F
H
H
H
OMe
OEt
OH
H
H
H
OEt
NMe
Me


I-2372
—NHCH2CH═CMe2
H
F
H
H
H
OMe
OEt
OH
H
H
H
OEt
O
—CH2CH═CMe2


I-2373
—NHCH2CH═CMe2
H
F
H
H
H
OMe
OEt
OH
H
H
H
OEt
O
—CH2CH═CCl2


I-2374
—NH2
H
F
H
H
Me
Me
Me
H
H
H
H
OMe
NH
—CH2CH═CMe2


I-2375
—NH2
H
F
H
H
Me
Me
Me
H
H
H
H
OMe
NH
—(CH2)2CHMe2































TABLE 317







I-2376
—NH2
H
F
H
H
Me
Me
Me
H
H
H
H
OMe
NMe
Me


I-2377
—NH2
H
F
H
H
Me
Me
Me
H
H
H
H
OMe
O
—CH2CH═CMe2


I-2378
—NH2
H
F
H
H
Me
Me
Me
H
H
H
H
OMe
O
—CH2CH═CCl2


I-2379
—NH2
H
F
H
H
Me
Me
Me
H
H
H
F
H
NH
—CH2CH═CMe2


I-230
—NH2
H
F
H
H
Me
Me
Me
H
H
H
F
H
NH
—(CH2)2CHMe2


I-2381
—NH2
H
F
H
H
Me
Me
Me
H
H
H
F
H
NMe
Me


I-2382
—NH2
H
F
H
H
Me
Me
Me
H
H
H
F
H
O
—CH2CH═CMe2


I-2383
—NH2
H
F
H
H
Me
Me
Me
H
H
H
F
H
O
—CH2CH═CCl2


I-2384
—NH2
H
F
H
H
Me
Me
Me
H
H
H
H
OEt
NH
—CH2CH═CMe2


I-2385
—NH2
H
F
H
H
Me
Me
Me
H
H
H
H
OEt
NH
—(CH2)2CHMe2


I-2386
—NH2
H
F
H
H
Me
Me
Me
H
H
H
H
OEt
NMe
Me


I-2387
—NH2
H
F
H
H
Me
Me
Me
H
H
H
H
OEt
O
—CH2CH═CMe2


I-2388
—NH2
H
F
H
H
Me
Me
Me
H
H
H
H
OEt
O
—CH2CH═CCl2


I-2389
—NH2
H
F
H
H
H
Me
OMe
OH
H
H
H
OMe
NH
—CH2CH═CMe2


I-2390
—NH2
H
F
H
H
H
Me
OMe
OH
H
H
H
OMe
NH
—(CH2)2CHMe2


I-2391
—NH2
H
F
H
H
H
Me
OMe
OH
H
H
H
OMe
NMe
Me


I-2392
—NH2
H
F
H
H
H
Me
OMe
OH
H
H
H
OMe
O
—CH2CH═CMe2


I-2393
—NH2
H
F
H
H
H
Me
OMe
OH
H
H
H
OMe
O
—CH2CH═CCl2


I-2394
—NH2
H
F
H
H
H
Me
OMe
OH
H
H
F
H
NH
—CH2CH═CMe2


I-2395
—NH2
H
F
H
H
H
Me
OMe
OH
H
H
F
H
NH
—(CH2)2CHMe2


I-2396
—NH2
H
F
H
H
H
Me
OMe
OH
H
H
F
H
NMe
Me































TABLE 318







I-2397
—NH2
H
F
H
H
H
Me
OMe
OH
H
H
F
H
O
—CH2CH═CMe2


I-2398
—NH2
H
F
H
H
H
Me
OMe
OH
H
H
F
H
O
—CH2CH═CCl2


I-2399
—NH2
H
F
H
H
H
Me
OMe
OH
H
H
H
OEt
NH
—CH2CH═CMe2


I-2400
—NH2
H
F
H
H
H
Me
OMe
OH
H
H
H
OEt
NH
—(CH2)2CHMe2


I-2301
—NH2
H
F
H
H
H
Me
OMe
OH
H
H
H
OEt
NMe
Me


I-2302
—NH2
H
F
H
H
H
Me
OMe
OH
H
H
H
OEt
O
—CH2CH═CMe2


I-2303
—NH2
H
F
H
H
H
Me
OMe
OH
H
H
H
OEt
O
—CH2CH═CCl2


I-2304
—NH2
H
F
H
H
Me
H
Me
OH
H
H
H
OMe
NH
—CH2CH═CMe2


I-2305
—NH2
H
F
H
H
Me
H
Me
OH
H
H
H
OMe
NH
—(CH2)2CHMe2


I-2306
—NH2
H
F
H
H
Me
H
Me
OH
H
H
H
OMe
NMe
Me


I-237
—NH2
H
F
H
H
Me
H
Me
OH
H
H
H
OMe
O
—CH2CH═CMe2


I-2308
—NH2
H
F
H
H
Me
H
Me
OH
H
H
H
OMe
O
—CH2CH═CCl2


I-2309
—NH2
H
F
H
H
Me
H
Me
OH
H
H
F
H
NH
—CH2CH═CMe2


I-2310
—NH2
H
F
H
H
Me
H
Me
OH
H
H
F
H
NH
—(CH2)2CHMe2


I-2311
—NH2
H
F
H
H
Me
H
Me
OH
H
H
F
H
NMe
Me


I-2312
—NH2
H
F
H
H
Me
He
Me
OH
H
H
F
H
O
—CH2CH═CMe2


I-2313
—NH2
H
F
H
H
Me
H
Me
OH
H
H
F
H
O
—CH2CH═CCl2


I-2314
—NH2
H
F
H
H
Me
H
Me
OH
H
H
H
OEt
NH
—CH2CH═CMe2


I-2315
—NH2
H
F
H
H
Me
H
Me
OH
H
H
H
OEt
NH
—(CH2)2CHMe2


I-236
—NH2
H
F
H
H
Me
H
Me
OH
H
H
H
OEt
NMe
Me


I-237
—NH2
H
F
H
H
Me
H
Me
OH
H
H
H
OEt
O
—CH2CH═CMe2































TABLE 319







I-2318
—NH2
H
F
H
H
Me
H
Me
OH
H
H
H
OEt
O
—CH2CH═CCl2


I-2319
—NH2
H
F
H
H
H
Me
Me
Me
H
H
H
OMe
NH
—CH2CH═CMe2


I-230
—NH2
H
F
H
H
H
Me
Me
Me
H
H
H
OMe
NH
—(CH2)2CHMe2


I-2321
—NH2
H
F
H
H
H
Me
Me
Me
H
H
H
OMe
NMe
Me


I-2322
—NH2
H
F
H
H
H
Me
Me
Me
H
H
H
OMe
O
—CH2CH═CMe2


I-2323
—NH2
H
F
H
H
H
Me
Me
Me
H
H
H
OMe
O
—CH2CH═CCl2


I-2324
—NH2
H
F
H
H
H
Me
Me
Me
H
H
F
H
NH
—CH2CH═CMe2


I-2325
—NH2
H
F
H
H
H
Me
Me
Me
H
H
F
H
NH
—(CH2)2CHMe2


I-236
—NH2
H
F
H
H
H
Me
Me
Me
H
H
F
H
NMe
Me


I-2327
—NH2
H
F
H
H
H
Me
Me
Me
H
H
F
H
O
—CH2CH═CMe2


I-2328
—NH2
H
F
H
H
H
Me
Me
Me
H
H
F
H
O
—CH2CH═CCl2


I-2329
—NH2
H
F
H
H
H
Me
Me
Me
H
H
H
OEt
NH
—CH2CH═CMe2


I-2330
—NH2
H
F
H
H
H
Me
Me
Me
H
H
H
OEt
NH
—(CH2)2CHMe2


I-2331
—NH2
H
F
H
H
H
Me
Me
Me
H
H
H
OEt
NMe
Me


I-2332
—NH2
H
F
H
H
H
Me
Me
Me
H
H
H
OEt
O
—CH2CH═CMe2


I-2333
—NH2
H
F
H
H
H
Me
Me
Me
H
H
H
OEt
O
—CH2CH═CCl2


I-2334
—NH2
H
F
H
H
H
OMe
OEt
OH
H
H
H
OMe
NH
—CH2CH═CMe2


I-2335
—NH2
H
F
H
H
H
OMe
OEt
OH
H
H
H
OMe
NH
—(CH2)2CHMe2


I-2336
—NH2
H
F
H
H
H
OMe
OEt
OH
H
H
H
OMe
NMe
Me


I-2337
—NH2
H
F
H
H
H
OMe
OEt
OH
H
H
H
OMe
O
—CH2CH═CMe2


I-2338
—NH2
H
F
H
H
H
OMe
OEt
OH
H
H
H
OMe
O
—CH2CH═CCl2































TABLE 320







I-2339
—NH2
H
F
H
H
H
OMe
OEt
OH
H
H
F
H
NH
—CH2CH═CMe2


I-2340
—NH2
H
F
H
H
H
OMe
OEt
OH
H
H
F
H
NH
—(CH2)2CHMe2


I-2341
—NH2
H
F
H
H
H
OMe
OEt
OH
H
H
F
H
NMe
Me


I-2342
—NH2
H
F
H
H
H
OMe
OEt
OH
H
H
F
H
O
—CH2CH═CMe2


I-2343
—NH2
H
F
H
H
H
OMe
OEt
OH
H
H
F
H
O
—CH2CH═CCl2


I-2344
—NH2
H
F
H
H
H
OMe
OEt
OH
H
H
H
OEt
NH
—CH2CH═CMe2


I-2345
—NH2
H
F
H
H
H
OMe
OEt
OH
H
H
H
OEt
NH
—(CH2)2CHMe2


I-2346
—NH2
H
F
H
H
H
OMe
OEt
OH
H
H
H
OEt
NMe
Me


I-2347
—NH2
H
F
H
H
H
OMe
OEt
OH
H
H
H
OEt
O
—CH2CH═CMe2


I-2348
—NH2
H
F
H
H
H
OMe
OEt
OH
H
H
H
OEt
O
—CH2CH═CCl2


I-2349
—NHCH2CH═CMe2
H
H
H
H
Me
Me
Me
H
H
H
H
OMe
NH
—CH2CH═CMe2


I-2350
—NHCH2CH═CMe2
H
H
H
H
Me
Me
Me
H
H
H
H
OMe
NH
—(CH2)2CHMe2


I-2351
—NHCH2CH═CMe2
H
H
H
H
Me
Me
Me
H
H
H
H
OMe
NMe
Me


I-2352
—NHCH2CH═CMe2
H
H
H
H
Me
Me
Me
H
H
H
H
OMe
O
—CH2CH═CMe2


I-2353
—NHCH2CH═CMe2
H
H
H
H
Me
Me
Me
H
H
H
H
OMe
O
—CH2CH═CCl2


I-2354
—NHCH2CH═CMe2
H
H
H
H
Me
Me
Me
H
H
H
F
H
NH
—CH2CH═CMe2


I-2355
—NHCH2CH═CMe2
H
H
H
H
Me
Me
Me
H
H
H
F
H
NH
—(CH2)2CHMe2


I-2356
—NHCH2CH═CMe2
H
H
H
H
Me
Me
Me
H
H
H
F
H
NMe
Me


I-2357
—NHCH2CH═CMe2
H
H
H
H
Me
Me
Me
H
H
H
F
H
O
—CH2CH═CMe2


I-238
—NHCH2CH═CMe2
H
H
H
H
Me
Me
Me
H
H
H
F
H
O
—CH2CH═CCl2


I-2359
—NHCH2CH═CMe2
H
H
H
H
Me
Me
Me
H
H
H
H
OEt
NH
—CH2CH═CMe2































TABLE 321







I-2360
—NHCH2CH═CMe2
H
H
H
H
Me
Me
Me
H
H
H
H
OEt
NH
—(CH2)2CHMe2


I-2361
—NHCH2CH═CMe2
H
H
H
H
Me
Me
Me
H
H
H
H
OEt
NMe
Me


I-2362
—NHCH2CH═CMe2
H
H
H
H
Me
Me
Me
H
H
H
H
OEt
O
—CH2CH═CMe2


I-2363
—NHCH2CH═CMe2
H
H
H
H
Me
Me
Me
H
H
H
H
OEt
O
—CH2CH═CCl2


I-2364
—NHCH2CH═CMe2
H
H
H
H
H
Me
OMe
OH
H
H
H
OMe
NH
—CH2CH═CMe2


I-2365
—NHCH2CH═CMe2
H
H
H
H
H
Me
OMe
OH
H
H
H
OMe
NH
—(CH2)2CHMe2


I-2366
—NHCH2CH═CMe2
H
H
H
H
H
Me
OMe
OH
H
H
H
OMe
NMe
Me


I-2367
—NHCH2CH═CMe2
H
H
H
H
H
Me
OMe
OH
H
H
H
OMe
O
—CH2CH═CMe2


I-2368
—NHCH2CH═CMe2
H
H
H
H
H
Me
OMe
OH
H
H
H
OMe
O
—CH2CH═CCl2


I-2369
—NHCH2CH═CMe2
H
H
H
H
H
Me
OMe
OH
H
H
F
H
NH
—CH2CH═CMe2


I-2370
—NHCH2CH═CMe2
H
H
H
H
H
Me
OMe
OH
H
H
F
H
NH
—(CH2)2CHMe2


I-2371
—NHCH2CH═CMe2
H
H
H
H
H
Me
OMe
OH
H
H
F
H
NMe
Me


I-2372
—NHCH2CH═CMe2
H
H
H
H
H
Me
OMe
OH
H
H
F
H
O
—CH2CH═CMe2


I-2373
—NHCH2CH═CMe2
H
H
H
H
H
Me
OMe
OH
H
H
F
H
O
—CH2CH═CCl2


I-2374
—NHCH2CH═CMe2
H
H
H
H
H
Me
OMe
OH
H
H
H
OEt
NH
—CH2CH═CMe2


I-2375
—NHCH2CH═CMe2
H
H
H
H
H
Me
OMe
OH
H
H
H
OEt
NH
—(CH2)2CHMe2


I-2376
—NHCH2CH═CMe2
H
H
H
H
H
Me
OMe
OH
H
H
H
OEt
NMe
Me


I-2377
—NHCH2CH═CMe2
H
H
H
H
H
Me
OMe
OH
H
H
H
OEt
O
—CH2CH═CMe2


I-2378
—NHCH2CH═CMe2
H
H
H
H
H
Me
OMe
OH
H
H
H
OEt
O
—CH2CH═CCl2


I-2379
—NHCH2CH═CMe2
H
H
H
H
Me
H
Me
OH
H
H
H
OMe
NH
—CH2CH═CMe2


I-2380
—NHCH2CH═CMe2
H
H
H
H
Me
H
Me
OH
H
H
H
OMe
NH
—(CH2)2CHMe2































TABLE 322







I-2381
—NHCH2CH═CMe2
H
H
H
H
Me
H
Me
OH
H
H
H
OMe
NMe
Me


I-2382
—NHCH2CH═CMe2
H
H
H
H
Me
H
Me
OH
H
H
H
OMe
O
—CH2CH═CMe2


I-2383
—NHCH2CH═CMe2
H
H
H
H
Me
H
Me
OH
H
H
H
OMe
O
—CH2CH═CCl2


I-2384
—NHCH2CH═CMe2
H
H
H
H
Me
H
Me
OH
H
H
F
H
NH
—CH2CH═CMe2


I-2385
—NHCH2CH═CMe2
H
H
H
H
Me
H
Me
OH
H
H
F
H
NH
—(CH2)2CHMe2


I-236
—NHCH2CH═CMe2
H
H
H
H
Me
H
Me
OH
H
H
F
H
NMe
Me


I-2387
—NHCH2CH═CMe2
H
H
H
H
Me
H
Me
OH
H
H
F
H
O
—CH2CH═CMe2


I-2388
—NHCH2CH═CMe2
H
H
H
H
Me
H
Me
OH
H
H
F
H
O
—CH2CH═CCl2


I-2389
—NHCH2CH═CMe2
H
H
H
H
Me
H
Me
OH
H
H
H
OEt
NH
—CH2CH═CMe2


I-2390
—NHCH2CH═CMe2
H
H
H
H
Me
H
Me
OH
H
H
H
OEt
NH
—(CH2)2CHMe2


I-2391
—NHCH2CH═CMe2
H
H
H
H
Me
H
Me
OH
H
H
H
OEt
NMe
Me


I-2392
—NHCH2CH═CMe2
H
H
H
H
Me
H
Me
OH
H
H
H
OEt
O
—CH2CH═CMe2


I-2393
—NHCH2CH═CMe2
H
H
H
H
Me
H
Me
OH
H
H
H
OEt
O
—CH2CH═CCl2


I-2394
—NHCH2CH═CMe2
H
H
H
H
H
Me
Me
Me
H
H
H
OMe
NH
—CH2CH═CMe2


I-2395
—NHCH2CH═CMe2
H
H
H
H
H
Me
Me
Me
H
H
H
OMe
NH
—(CH2)2CHMe2


I-2396
—NHCH2CH═CMe2
H
H
H
H
H
Me
Me
Me
H
H
H
OMe
NMe
Me


I-2397
—NHCH2CH═CMe2
H
H
H
H
H
Me
Me
Me
H
H
H
OMe
O
—CH2CH═CMe2


I-2398
—NHCH2CH═CMe2
H
H
H
H
H
Me
Me
Me
H
H
H
OMe
O
—CH2CH═CCl2


I-2399
—NHCH2CH═CMe2
H
H
H
H
H
Me
Me
Me
H
H
F
H
NH
—CH2CH═CMe2


I-2400
—NHCH2CH═CMe2
H
H
H
H
H
Me
Me
Me
H
H
F
H
NH
—(CH2)2CHMe2


I-2401
—NHCH2CH═CMe2
H
H
H
H
H
Me
Me
Me
H
H
F
H
NMe
Me































TABLE 323







I-2402
—NHCH2CH═CMe2
H
H
H
H
H
Me
Me
Me
H
H
F
H
O
—CH2CH═CMe2


I-2403
—NHCH2CH═CMe2
H
H
H
H
H
Me
Me
Me
H
H
F
H
O
—CH2CH═CCl2


I-2404
—NHCH2CH═CMe2
H
H
H
H
H
Me
Me
Me
H
H
H
OEt
NH
—CH2CH═CMe2


I-2405
—NHCH2CH═CMe2
H
H
H
H
H
Me
Me
Me
H
H
H
OEt
NH
—(CH2)2CHMe2


I-2406
—NHCH2CH═CMe2
H
H
H
H
H
Me
Me
Me
H
H
H
OEt
NMe
Me


I-2407
—NHCH2CH═CMe2
H
H
H
H
H
Me
Me
Me
H
H
H
OEt
O
—CH2CH═CMe2


I-2408
—NHCH2CH═CMe2
H
H
H
H
H
Me
Me
Me
H
H
H
OEt
O
—CH2CH═CCl2


I-2409
—NHCH2CH═CMe2
H
H
H
H
H
OMe
OEt
OH
H
H
H
OMe
NH
—CH2CH═CMe2


I-2410
—NHCH2CH═CMe2
H
H
H
H
H
OMe
OEt
OH
H
H
H
OMe
NH
—(CH2)2CHMe2


1-2411
—NHCH2CH═CMe2
H
H
H
H
H
OMe
OEt
OH
H
H
H
OMe
NMe
Me


I-2412
—NHCH2CH═CMe2
H
H
H
H
H
OMe
OEt
OH
H
H
H
OMe
O
—CH2CH═CMe2


I-2413
—NHCH2CH═CMe2
H
H
H
H
H
OMe
OEt
OH
H
H
H
OMe
O
—CH2CH═CCl2


I-2414
—NHCH2CH═CMe2
H
H
H
H
H
OMe
OEt
OH
H
H
F
H
NH
—CH2CH═CMe2


I-2415
—NHCH2CH═CMe2
H
H
H
H
H
OMe
OEt
OH
H
H
F
H
NH
—(CH2)2CHMe2


I-2416
—NHCH2CH═CMe2
H
H
H
H
H
OMe
OEt
OH
H
H
F
H
NMe
Me


I-2417
—NHCH2CH═CMe2
H
H
H
H
H
OMe
OEt
OH
H
H
F
H
O
—CH2CH═CMe2


I-2418
—NHCH2CH═CMe2
H
H
H
H
H
OMe
OEt
OH
H
H
F
H
O
—CH2CH═CCl2


I-2419
—NHCH2CH═CMe2
H
H
H
H
H
OMe
OEt
OH
H
H
H
OEt
NH
—CH2CH═CMe2


I-2420
—NHCH2CH═CMe2
H
H
H
H
H
OMe
OEt
OH
H
H
H
OEt
NH
—(CH2)2CHMe2


I-2421
—NHCH2CH═CMe2
H
H
H
H
H
OMe
OEt
OH
H
H
H
OEt
NMe
Me


I-2422
—NHCH2CH═CMe2
H
H
H
H
H
OMe
OEt
OH
H
H
H
OEt
O
—CH2CH═CMe2































TABLE 324







I-2423
—NHCH2CH═CMe2
H
H
H
H
H
OMe
OEt
OH
H
H
H
OEt
O
—CH2CH═CCl2


I-2424
—OMe
H
H
H
H
Me
Me
Me
H
H
H
H
OMe
NH
—CH2CH═CMe2


I-2425
—OMe
H
H
H
H
Me
Me
Me
H
H
H
H
OMe
NH
—(CH2)2CHMe2


I-2426
—OMe
H
H
H
H
Me
Me
Me
H
H
H
H
OMe
NMe
Me


I-2427
—OMe
H
H
H
H
Me
Me
Me
H
H
H
H
OMe
O
—CH2CH═CMe2


I-2428
—OMe
H
H
H
H
Me
Me
Me
H
H
H
H
OMe
O
—CH2CH═CCl2


I-2429
—OMe
H
H
H
H
Me
Me
Me
H
H
H
F
H
NH
—CH2CH═CMe2


I-2430
—OMe
H
H
H
H
Me
Me
Me
H
H
H
F
H
NH
—(CH2)2CHMe2


I-2431
—OMe
H
H
H
H
Me
Me
Me
H
H
H
F
H
NMe
Me


I-2432
—OMe
H
H
H
H
Me
Me
Me
H
H
H
F
H
O
—CH2CH═CMe2


I-2433
—OMe
H
H
H
H
Me
Me
Me
H
H
H
F
H
O
—CH2CH═CCl2


I-2434
—OMe
H
H
H
H
Me
Me
Me
H
H
H
H
OEt
NH
—CH2CH═CMe2


I-2435
—OMe
H
H
H
H
Me
Me
Me
H
H
H
H
OEt
NH
—(CH2)2CHMe2


I-2436
—OMe
H
H
H
H
Me
Me
Me
H
H
H
H
OEt
NMe
Me


I-2437
—OMe
H
H
H
H
Me
Me
Me
H
H
H
H
OEt
O
—CH2CH═CMe2


I-2438
—OMe
H
H
H
H
Me
Me
Me
H
H
H
H
OEt
O
—CH2CH═CCl2


I-2439
—OMe
H
H
H
H
H
Me
OMe
OH
H
H
H
OMe
NH
—CH2CH═CMe2


I-2440
—OMe
H
H
H
H
H
Me
OMe
OH
H
H
H
OMe
NH
—(CH2)2CHMe2


I-2441
—OMe
H
H
H
H
H
Me
OMe
OH
H
H
H
OMe
NMe
Me


I-2442
—OMe
H
H
H
H
H
Me
OMe
OH
H
H
H
OMe
O
—CH2CH═CMe2


I-2443
—OMe
H
H
H
H
H
Me
OMe
OH
H
H
H
OMe
O
—CH2CH═CCl2































TABLE 325







I-2444
—OMe
H
H
H
H
H
Me
OMe
OH
H
H
F
H
NH
—CH2CH═CMe2


I-2445
—OMe
H
H
H
H
H
Me
OMe
OH
H
H
F
H
NH
—(CH2)2CHMe2


I-2446
—OMe
H
H
H
H
H
Me
OMe
OH
H
H
F
H
NMe
Me


I-2447
—OMe
H
H
H
H
H
Me
OMe
OH
H
H
F
H
O
—CH2CH═CMe2


I-2448
—OMe
H
H
H
H
H
Me
OMe
OH
H
H
F
H
O
—CH2CH═CCl2


I-2449
—OMe
H
H
H
H
H
Me
OMe
OH
H
H
H
OEt
NH
—CH2CH═CMe2


I-2450
—OMe
H
H
H
H
H
Me
OMe
OH
H
H
H
OEt
NH
—(CH2)2CHMe2


I-2451
—OMe
H
H
H
H
H
Me
OMe
OH
H
H
H
OEt
NMe
Me


I-2452
—OMe
H
H
H
H
H
Me
OMe
OH
H
H
H
OEt
O
—CH2CH═CMe2


I-2453
—OMe
H
H
H
H
H
Me
OMe
OH
H
H
H
OEt
NH
—CH2CH═CMe2


I-2454
—OMe
H
H
H
H
Me
H
Me
OH
H
H
H
OMe
NH
—CH2CH═CMe2


I-2455
—OMe
H
H
H
H
Me
H
Me
OH
H
H
H
OMe
NH
—(CH2)2CHMe2


I-2456
—OMe
H
H
H
H
Me
H
Me
OH
H
H
H
OMe
NMe
Me


I-2457
—OMe
H
H
H
H
Me
H
Me
OH
H
H
H
OMe
O
—CH2CH═CMe2


I-2458
—OMe
H
H
H
H
Me
H
Me
OH
H
H
H
OMe
O
—CH2CH═CCl2


I-2459
—OMe
H
H
H
H
Me
H
Me
OH
H
H
F
H
NH
—CH2CH═CMe2


I-2460
—OMe
H
H
H
H
Me
H
Me
OH
H
H
F
H
NH
—(CH2)2CHMe2


I-2461
—OMe
H
H
H
H
Me
H
Me
OH
H
H
F
H
NMe
Me


I-2462
—OMe
H
H
H
H
Me
H
Me
OH
H
H
F
H
O
—CH2CH═CMe2


I-2463
—OMe
H
H
H
H
Me
H
Me
OH
H
H
F
H
O
—CH2CH═CCl2


I-2464
—OMe
H
H
H
H
Me
H
Me
OH
H
H
H
OEt
NH
—CH2CH═CMe2































TABLE 326







I-2465
—OMe
H
H
H
H
Me
H
Me
OH
H
H
H
OEt
NH
—(CH2)2CHMe2


I-2466
—OMe
H
H
H
H
Me
H
Me
OH
H
H
H
OEt
NMe
Me


I-2467
—OMe
H
H
H
H
Me
H
Me
OH
H
H
H
OEt
O
—CH2CH═CMe2


I-2468
—OMe
H
H
H
H
Me
H
Me
OH
H
H
H
OEt
O
—CH2CH═CCl2


I-2469
—OMe
H
H
H
H
H
Me
Me
Me
H
H
H
OMe
NH
—CH2CH═CMe2


I-2470
—OMe
H
H
H
H
H
Me
Me
Me
H
H
H
OMe
NH
—(CH2)2CHMe2


I-2471
—OMe
H
H
H
H
H
Me
Me
Me
H
H
H
OMe
NMe
Me


I-2472
—OMe
H
H
H
H
H
Me
Me
Me
H
H
H
OMe
O
—CH2CH═CMe2


I-2473
—OMe
H
H
H
H
H
Me
Me
Me
H
H
H
OMe
O
—CH2CH═CCl2


I-2474
—OMe
H
H
H
H
H
Me
Me
Me
H
H
F
H
NH
—CH2CH═CMe2


I-2475
—OMe
H
H
H
H
H
Me
Me
Me
H
H
F
H
NH
—(CH2)2CHMe2


I-2476
—OMe
H
H
H
H
H
Me
Me
Me
H
H
F
H
NMe
Me


I-2477
—OMe
H
H
H
H
H
Me
Me
Me
H
H
F
H
O
—CH2CH═CMe2


I-2478
—OMe
H
H
H
H
H
Me
Me
Me
H
H
F
H
O
—CH2CH═CCl2


I-2479
—OMe
H
H
H
H
H
Me
Me
Me
H
H
H
OEt
NH
—CH2CH═CMe2


I-2480
—OMe
H
H
H
H
H
Me
Me
Me
H
H
H
OEt
NH
—(CH2)2CHMe2


I-2481
—OMe
H
H
H
H
H
Me
Me
Me
H
H
H
OEt
NMe
Me


I-2482
—OMe
H
H
H
H
H
Me
Me
Me
H
H
H
OEt
O
—CH2CH═CMe2


I-2483
—OMe
H
H
H
H
H
Me
Me
Me
H
H
H
OEt
O
—CH2CH═CCl2


I-2484
—OMe
H
H
H
H
H
OMe
OEt
OH
H
H
H
OMe
NH
—CH2CH═CMe2


I-2485
—OMe
H
H
H
H
H
OMe
OEt
OH
H
H
H
OMe
NH
—(CH2)2CHMe2































TABLE 327







I-2486
—OMe
H
H
H
H
H
OMe
OEt
OH
H
H
H
OMe
NMe
Me


I-2487
—OMe
H
H
H
H
H
OMe
OEt
OH
H
H
H
OMe
O
—CH2CH═CMe2


I-2488
—OMe
H
H
H
H
H
OMe
OEt
OH
H
H
H
OMe
O
—CH2CH═CCl2


I-2489
—OMe
H
H
H
H
H
OMe
OEt
OH
H
H
F
H
NH
—CH2CH═CMe2


I-2490
—OMe
H
H
H
H
H
OMe
OEt
OH
H
H
F
H
NH
—(CH2)2CHMe2


I-2491
—OMe
H
H
H
H
H
OMe
OEt
OH
H
H
F
H
NMe
Me


I-2492
—OMe
H
H
H
H
H
OMe
OEt
OH
H
H
F
H
O
—CH2CH═CMe2


I-2493
—OMe
H
H
H
H
H
OMe
OEt
OH
H
H
F
H
O
—CH2CH═CCl2


I-2494
—OMe
H
H
H
H
H
OMe
OEt
OH
H
H
H
OEt
NH
—CH2CH═CMe2


I-2495
—OMe
H
H
H
H
H
OMe
OEt
OH
H
H
H
OEt
NH
—(CH2)2CHMe2


I-2496
—OMe
H
H
H
H
H
OMe
OEt
OH
H
H
H
OEt
NMe
Me


I-2497
—OMe
H
H
H
H
H
OMe
OEt
OH
H
H
H
OEt
O
—CH2CH═CMe2


I-2498
—OMe
H
H
H
H
H
OMe
OEt
OH
H
H
H
OEt
O
—CH2CH═CCl2









In the above tables, “—OCH2O—*” and “*” mean that they taken together form a ring.
Experiment 1 Suppressive Effect on a Mitogenic Activity of Mouse Splenocytes In Vitro
In 96-well microtiter plate 5×105 C3H/HeN mouse splenocytes suspended in 0.1 ml of 10% fetal bovine serum-fortified RPMI 1640 medium containing 2 mM of sodium bicarbonate, 50 units/ml of penicillin, 50 μg/ml of streptomycin and 5×10−5 M of 2-mercaptoethanol were added. Then, 5 μg/ml of Concanavalin A (Con A) or 10 μg/ml of lipopolysaccharide (LPS) as a mitogen and the compound of a pre-determined concentration of the present invention were added to each well so that a final volume of each well reached 0.2 ml. Each compound of the present invention was dissolved in dimethylsulfoxide (DMSO) and diluted with the above RPMI 1640 medium to adjust the final concentration of 100 ng/ml or less. The splenocytes in the 96-well microtiter plate were cultivated at 37° C. for 3 days in an incubator keeping the humidity 100%, carbon dioxide 5% and air 95%. Then, 25 μl of 6 mg/ml MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] (Sigma) was added to the each well and cultivated at 37° C. for 4 hours under the same conditions. After the cultivation, 50 μl of 0.02 N hydrochloric acid in 20% sodium dodecyl sulfate (SDS) was added to formazan generated and left at 37° C. for 24 hours for dissolving formazan. An absorption intensity (OD) of formazan generated in proportion to the number of living cells was measured with an immunoreader (InterMed) equipped with a 570 nm filter (The Journal of Immunological Method, 65, 55–63, 1983). The 50% inhibitory concentration of a cell proliferation (IC 50) was calculated from a correlation between the concentration of the compound of the present invention and the absorption intensity.
Experiment 2 Anti-Proliferative Activity on EL4 Cells
In 96-well microtiter plate 4×104/0.1 ml of mouse thymoma strain EL4 cells were added and 0.1 ml of the compound of the present invention was added to the mixture so that the concentration was in the range of 0–5,000 ng/ml. After the cultivation for 3 days, the IC50 was calculated by the MTT method as described in Experiment 1.
The results are shown in Tables 328–329.












TABLE 328








ConA
LPS
EL-4




IC50
IC50
IC50



Compound
(ng/ml)
(ng/ml)
(ng/ml)





















I-1
0.86
1.92
8.56



I-9
<20
<20
<20



I-12
1.3
2.8
46.2



I-22
5.62
4.26
6.2



I-35
19.5
39.4
140



I-40
6.1
16.5
37.4



I-41
0.73
1.74
4.89



I-46
10.6
23.9
67.5



I-49
8.89
16.2
31.7



I-50
3.83
9.2
11.9



I-51
6.6
14.7
70.0



I-59
8.5
22.4
140



I-62
29.2
25
23.4



I-63
13
27
16



I-66
0.22
0.35
0.48



I-71
4.56
14.2
31.2



I-101
0.8
0.5
1.8



I-103
3.4
3.7
4.6



I-104
3.0
3.1
4.8



I-106
0.6
0.4
2.7



I-107
0.6
0.7
12



I-121
0.8
1.2
0.8



I-163
<20
<20
<20



I-173
<20
<20
<20



I-175
<20
29.4
<20



I-187
12.0
25.1
36.2



I-211
<20
<20
<20



I-248
<10
<10
312



I-250
<10
<10
88.3



I-251
<10
<10
97.4



I-255
<20
<20
<20



I-256
<20
28.7
310



I-275
6.34
13.5
100



I-276
1.8
3.1
200



I-299
5.53
7.85
13.6



I-301
7.06
11.0
15.8



I-360
<20
<20
99.8



I-361
<20
<20
124



I-418
255
497
>10000



I-427
255
497
>10000



I-457
<20
<20
205



I-466
<20
<20
46



I-484
14.7
32.2
91.4



I-513
6.89
11.1
61.8



I-525
0.76
1.11
5.0



I-639
4.59
6.25
50



I-661
0.67
1.28
50



I-739
18.8
20.7
430



I-742
10
20
45.2



I-758
6.78
9.63
55.1



I-773
8.45
12.6
92.9



I-797
1.75
3.71
26.5



I-834
36
46
226



I-839
1.48
1.87
20.7



I-840
5.31
6.94
31.9



I-878
14.1
27.4
194



I-880
23.0
41.1
105



I-892
<0.2
<0.2
1.41



I-893
0.49
1.05
7.06






















TABLE 329








ConA
LPS
EL-4




IC50
IC50
IC50



Compound
(ng/ml)
(ng/ml)
(ng/ml)





















I-907
23.4
44.5
82.7



I-908
0.45
0.86
3.50



I-909
<20
<20
20



I-931
2.93
5.76
4.37



I-934
16.1
22.2
52.7



I-943
2.97
4.89
46.8



I-962
12.1
16.3
20.4



I-970
<20
<20
50.3



I-976
17.7
34.2
330



I-981
14.9
27.1
>100



I-982
2.0
3.75
55.3



I-988
0.2
0.31
1.23



I-993
5.10
7.54
13.8



I-995
20.9
25.2
49.2



I-1006
8.66
12.3
33.0



I-1007
8.05
10.4
13.1



I-1017
9.74
16.7
72.9



I-1031
<20
21. 2
41.7



I-1040
1.80
5.31
1.85



I-1043
2.19
3.27
9.70



I-1058
21.2
30.2
48.8



I-1066
3.91
4.87
20.6



I-1095
6.90
9.57
34.2



I-1103
4.7
6.9
31.4



I-1107
5.8
9.1
34.1



I-1115
<20
<20
<20



I-1121
3.12
9.0
18.6



I-1123
0.80
2.00
3.9



I-1124
94
272
>10000



I-1126
79
234
>10000



I-1127
44
111
412



I-1128
5.00
11.4
26.0



I-1135
1.00
2.70
11.7



I-1160
10.6
14.1
97.4



I-1161
2.4
4.2
33.2



I-1162
0.65
1.95
30.9



I-1167
0.08
0.23
8.1



I-1168
0.26
0.54
12.5



I-1171
0.63
0.64
27.5



I-1172
13.1
19.4
>100



I-1173
16.4
31.1
>100



I-1177
12.2
20.8
47.2



I-1191
0.16
0.66
22.8



I-1193
1.46
5.3
50



I-1203
14.1
>100
43.5



I-1212
12.87
24.2
85.0



I-1217
<20
<20
<20



I-1227
197
423
>10000



I-1229
5.95
8.05
20.4



I-1230
12.0
15.3
5.22



I-1232
3.77
4.93
15.1



I-1240
2.50
3.34
11.8



I-1248
25.9
36.8
118



I-1250
0.68
1.35
2.90



I-1251
6.30
10.7
27.8



I-1263
<20
<20
29.8



I-1271
0.10
0.32
1.66



I-1274
0.33
1.38
1.44



I-1276
<20
31.3
105



I-1277
<20
<20
<20



I-1278
<20
<20
41.7



I-1284
<20
<20
<20



I-1286
<20
<20
<20



I-1289
<20
<20
<20



I-1290
<20
<20
27.3



I-1295
<20
<20
<20



I-1296
<20
<20
39.7










As shown in the above, the compound of the present invention has immunosuppressive and anti-allergic effects.
Experiment 3 Suppressive Effect on the Antibody Production Against Bovine γ Globulin (BGG)
On an immunizing day and 7 days after, 50 μg of BGG was subcutaneously inoculated to backs of BALB/c mice (male, 6–8 weeks old) for inducing an immune reaction. After the compound of the present invention was dissolved or suspended in N, N-dimethylacetoamide, the mixture was diluted with miglyol 812 neutral oil. A proper volume of the compound was orally administered (p.o.) to mice every day from the next day of the immunizing. A two hundredth weight to body weight of miglyol was administered to mice in a control group. After 21 days, blood was drawn from each mouse and a serum was separated. BGG-specific IgE in a serum was measured by the sandwich ELISA method using a BGG-coating plate. The suppressive rate of IgE production was calculated from the dilution rate of the serum which has the same absorption intensity as that of the control group for judging the effect of the compound of the present invention. The results are shown in Table 330.











TABLE 330









Suppressive rate of




Dose
antigen-specific IgE



Compound
(mg/kg)
(%)




















I-525
100
>95



I-915
100
>99



I-892
5
>99



I-963
50
>99



I-1031
100
>99



I-1093
100
>99










Experiment 4 Suppressive Effect on the IgE Production Against Ovalbumin (OVA)
1) Animals
BALB/c mice (female, 8–10 weeks old) and Wistar rats (female, 8–10 weeks old) which were bought from Japan SLC, Inc. (Shizuoka) were used.
2) Immunizing Method
BALB/c mice were immunized by an intraperitoneal administration of 0.2 ml suspension of 2 μg of ovalbumin (OVA) and 2 mg of aluminium hydroxide gel in physiological saline. After 10 days, blood was drawn from hearts, sera were separated and stocked at −40° C. till the measurement of an IgE antibody titer.
3) Compounds
After the compound of the present invention was dissolved or suspended in N,N-dimethylacetoamide, the mixture was diluted 20 times with miglyol 812 neutral oil. The obtained solution was orally administered to mice at 0.1 ml per mouse. The administration was continued for 10 days from the immunizing day to the day before drawing blood. IPD-1151-T (a compound described in Jpn. Pharmacol. (1993) 61, 3139) and a compound No. 36 (a compound 36 described in J. Med. Chem. (1997) 40: 395–407) were examined as controls by the same method.
4) Measurement of Anti-OVA IgE Antibody Titer (PCA Titer)
The samples 2-fold diluted with physiological saline were prepared from the obtained mouse serum and each 50 μl of the solution was intradermally injected to backs of Wistar rats which previously hair cut. After 24 hours, a passive cutaneous anaphylaxis reaction (PCA) was induced by an intravenous injection of 0.5 ml of physiological saline containing 1 mg of OVA and 5 mg of Evans' blue dye. After 30 minutes, the rats were sacrified and the highest dilution rate of the serum giving bluing with a diameter of more than 5 mm was recorded as the PCA titer. For example, when a serum is positive for the PCA reaction till 27 times dilution, the anti-OVA IgE antibody titer of the mouse is defined as 7. The results are shown in Table 331.









TABLE 331





Compound
Dose (mg/kg)
PCA Titer







I-484 
40
<0   


I-839 
40
2.4**


I-851 
40
1.8**


I-892 
40
<0   


I-893 
40
2.5**


I-908 
40
3.4**


I-915 
40
<0   


I-925 
40
1**  


I-928 
40
<0   


I-948 
40
2.6**


I-957 
40
4.5**


I-962 
40
<0   


I-963 
40
3.6**


I-988 
40
0.8**


I-1031
40
4.4**


I-1043
40
4.8**


I-1066
40
<0   


I-1072
40
0.8**


I-1095
40
<0   


I-1123
40
2.4**


I-1135
40
4.8**


I-1167
40
4.4**


I-1171
40
<0   


I-1177
40
3.6**


I-1229
40
<0   


I-1232
40
1.8**


I-1242
40
2.8**


I-1258
40
1.2**


I-1271
40
<0   


IPD-1151-T
50
9.8 


No. 36
10
10.4  





**P < 0.01 vs vehicle






The PCA titers of mice in a group to which any compound was not administered were 9–12.




As shown in the above, the compound of the present invention has a suppressive effect on the antibody production.
Experiment 5 Suppressive Effect on the Antibody Production of Human Lymphocytes
1. Experimental Method
1) Human Peripheral Blood
Human peripheral blood was drawn from healthy male adults by plastic syringes filled with heparin (final concentration 1.5%). Lymphocytes were collected immediately after blood was drawn.
2) Medium
RPMI medium (Nissui Pharmaceutical Co., Ltd.) containing 10% fetal bovine serum (HyClone Lab.) inactivated at 56° C. for 30 minutes, penicillin (100 units/ml) and streptomycin (100 μg/ml) (GIBCO) was used.
3) Compounds
After the compound (I-839) of the present invention was dissolved in dimethylsulfoxide (Nakaraitesk) at 2 μg/ml, the solution was diluted with the medium to adjust a final concentration to be 0.01 pg/ml–10 μg/ml. The compound No. 36 was examined as a control by the same method.
4) Human Lymphocytes
Human peripheral blood was stratified in a tube filled with Ficoll-Hypaque mixture solution (Dainippon Pharmaceutical Co., Ltd. (Osaka), Mono-poly resolving medium) at the same volume and centrifuged at 300×g at 15° C. for 30 minutes to obtain a lymphocytes layer. After the collected cell suspension was washed with sterile Hanks' solution (Nissui Pharmaceutical Co., Ltd.) by centrifugation, sterile distilled water was added to the suspension. After 30 seconds, twice-concentrated Hanks' solution of which amount is equal to the water was added for removal of contaminating erythrocytes. Lymphocytes which were filtered by a nylon mesh and washed by centrifugation were used for experiments as human lymphocytes.
5) Induction of the IgE Antibody Production by Stimulation of B Cells
In 96-well cultivating plate (Sumitomo bakelite) the lymphocytes were inoculated 2×105 cells per well, and the compound, anti-human CD 40 antigen (Pharmingen, 2 μg/ml), human recombinant interleukin-4 (IL-4) (Genzyme, 0.1 μg/ml) and human recombinant interleukin-10 (IL-10) (Genzyme, 0.2 μg/ml) were added and cultivated at 37° C. under 5% of CO2 (0.2 ml/well). After the cultivation for 10 days, the amount of antibody in a supernatant was quantified by ELISA method.
6) Quantification of the IgE Antibody
A commercial kit MESACUP IgE test (Medical & Biological Laboratories Co., Ltd.) was used for the quantification of the IgE. The experiment followed an instruction manual and was carried out in triplicate to calculate the average.
7) Quantification of the IgG and IgM Antibodies
ELISA method was used for the quantification. In 96-well plate (Nunc) 50 μl of 1 μg/ml F(ab′)2 Goat Anti-human IgG+A+M (H+ L) (ZYMED Laboratories) was added and the plate was coated at 4° C. overnight. The plate was washed twice with 0.05% Tween/PBS (PBST) solution and 10011 of 0.5% gelatin/PBST was added for blocking at room temperature for 2 hours. After washing three times with PBST, 100 μl of a sample diluted with PBS or 100 μl of human Plasma IgG standard solution or IgM standard solution (BioPur AG, Switzerland) of a pre-determined concentration was added and incubated at room temperature for 1 hour. After washing three times with PBST, 100 μl of a peroxydase-labeled anti-human IgG antibody or anti-human IgM antibody (Southern Biotechnology, Birmingham) which was diluted two thousandth with PBS was added and incubated at room temperature for 1 hour. After washing four times with PBST, 100 μl of a substrate, o-phenylenediamine dihydrochloride, was added for color development. After 30 minutes, the reaction was terminated by addition of 50 μL of 2 N HCl, and the absorption at 492 nm was measured with a microplate reader and the amount of the IgG and IgM was calculated from a standard curve of a standard solution.
2. Results
The results are shown in FIGS. 1 and 2. The compound (I-839) of the present invention has a selective suppressive effect on the IgE antibody production and the intensity was 2,000 times or more of that of the IgG production and 30,000 times or more of that of the IgM. The suppressive effects of the typical compounds on the antibody production are shown in Table 332.









TABLE 332









/IC50 (ng/ml)












Compound
IgE
IgG
IgM
















I-839
<0.00001
0.027
0.37



I-892
<0.00001
<0.00001
>1



I-121
<0.0001
<0.0001
>1



I-988
<0.00001
<0.00001
>1



I-893
<0.00001
<0.0001
>1










Experiment 6 Suppressive Effect on Antibody Production of Mouse Spleen Lymphocytes
1. Experimental Method
1) Animals
BALB/c (nu/nu) mice were bought from Japan SLC, Inc. (Shizuoka) and 7 weeks old-male mice were used.
2) Medium
RPMI medium (Nissui Pharmaceutical Co., Ltd.) containing 10% fetal bovine serum (HyClone Lab.) inactivated at 56° C. for 30 minutes, penicillin (100 units/ml) and streptomycin (100 μg/ml) (GIBCO) was used for experiments.
3) Compounds
Each of the compounds was dissolved in dimethylsulfoxide (Nakaraitesk) at 2 μg/ml and diluted with the medium to adjust a final concentration to 0.1 pg/ml–10 μg/ml.
4) Mouse Spleen Lymphocytes
A spleen of mouse was taken out and put in a cultivating schale which was filled with Hanks' solution. The spleen was crushed and the cells were pushed out from the organ and filtered through a metal mesh (200 mesh). After the collected cell suspension was washed by centrifugation with sterile Hanks' solution (Nissui Pharmaceutical Co., Ltd.), sterile distilled water was added. After 30 seconds, an equal amount of twice-concentrated Hanks' solution was added for removal of contaminating erythrocytes. The cell suspension, filtered by a nylon mesh and washed by centrifugation, were used as mouse spleen lymphocytes for experiments.
5) Induction of the IgE Antibody Production by the B Cell Stimulation
In 96-well cultivating plate (Sumitomo Bakelite Company Limited) mouse spleen lymphocytes were inoculated 2×105 cells per well. The compound of the present invention, lipopolysaccharide (DIFCO Lab., 2 μg/ml) and mouse recombinant interleukin-4 (IL-4) (Genzyme, 50 ng/ml) were added to the well and cultivated at 37° C. under 5% CO2 (0.2 ml/well). After the cultivation for 10 days, the amount of the antibody in a supernatant was quantified by ELISA method.
6) Quantification of the IgE Antibody
A commercial mouse IgE EIA kit (Yamasa Shoyu Co., Ltd.) was used for the quantification of the IgE. The experiment followed an instruction manual and was carried out in triplicate to calculate the average.
7) Quantification of the IgG1, IgG2a and IgM Antibodies
In 96-well plate 5011 of 10 μg/ml Goat Anti-Mouse Ig (IgM+G+A, H+ L) (Southern Biotechnology, Birmingham) was added and the plate was coated at 4° C. overnight. After the plate was washed twice with a PBST solution, 100 μl of 0.5% gelatin/PBST was added and the plate was blocked at room temperature for 2 hours. After washing three times with PBST, 100 μl of culture supernatant which was diluted with PBS or 100 μl of an antibody standard solution (Mouse IgG1 standard, Mouse IgG2a standard, Mouse IgM standard, BETHYL Laboratories) of a pre-determined concentration was added and incubated for 1 hour. After washing three times with PBST, 100 μl of diluted solution of alkalinephosphatase-labeled anti-mouse IgG1, IgG2a or IgM antibody (Southern Biotechnology, Birmingham) was added and incubated at room temperature for 1 hour. After washing four times with PBST, a substrate, p-nitrophenyl phosphate disodium, was added, and after 30 minutes-incubation period, after 5 N—NaOH was added to stop the reaction. The absorption at 405 nm was measured with a microplate reader, and the amount of the antibody was calculated from the standard curve. For the dilution of the mouse sample and the standard solution was used 10% FCS/PBS.
2. Results
The results are shown in FIG. 3. The figure shows that the compound (I-967) has a suppressive effect on the IgG1, IgG2a and IgM antibodies production only at 1000 ng/ml or more but has a dose-dependent suppressive effect on the IgE production at 0.01 ng/ml or more. In Table 333 the suppressive effects of the representative compounds on the IgE, IgM, IgG1 and IgG2a production are shown.










TABLE 333









IC50 (ng/ml)












Compound
IgE
IgG1
IgG2a
IgM














I-73
0.044
2600
4900
4200


I-963
0.00026
510
3600
3500


I-967
0.1
3500
3600
>10000









Experiment 7 Suppressive Effect on Bronchial Inflammatory Cell Infiltration by Inhalation of Antigen
1. Experimental Method
1) Animals
BALB/c mice bought from Japan SLC, Inc. (Shizuoka) (female, 8–11 weeks old) were used for experiments.
2) Sensitizing and Challenge of Antigen
For immunizing, 0.2 ml of a suspension of 2 μg of ovalbumin (OVA; Grade V, SIGMA) and 2 mg of aluminium hydroxide gel in physiological saline was intraperitoneally injected. After 2 weeks, 0.2 ml of a solution of 2 μg of OVA in physiological saline was intraperitoneally injected for a booster. After 1 week, each of mice was put in a nebulizing container (an airtight polycarbonate container, 24.5 cm in inner diameter and 20 cm in effective inner height, equipped with 12 cylindrical tubes of 4.8 cm in inner diameter and 12 cm in height) and made inhale a solution of 5% ovalbumin (Grade III, SIGMA) in physiological saline for 20 minutes with an ultrasonic neblizer (Omron Tateisi Elec-Tronics co., NE-U12) for the challenge of antigen.
3) Administration of the Compound of the Present Invention
The compound (I-963) of the present invention was dissolved in N,N-dimethylacetoamide (Nakaraitesk) and diluted one twentieth with miglyol 812 neutral oil (Mitsuba Trading Co., Ltd.) and the solution was orally administered to mice at 40 mg/kg. The administration was continued for 9 days from the booster day to the day before broncho-alveolar lavage.
4) Broncho-Alveolar Lavage (BAL)
After 48 hours of the challenge of antigen, the mice were exsanguinated from hearts under ether anesthetic, and the trachea was then cannulated. 0.3 ml of PBS were injected into the lungs and collected, and reinjected four times more (total 1.5 ml).
5) Measurement of the Total Cell Number in BAL Solution and Classification of Inflammatory Cells
After calculation of the total cell number by coloring of a part of BAL solution with Turk solution, cells in BAL solution were put on a slide glass with cytospin (SHANDON) for May-Grünwald-Giemsa (MERCK) staining. Under a microscope, 500 cells were classified to a macrophage, an eosinophil, a neutrophil and a lymphocyte and a proportion of each type of the cells was calculated. The number of each type of the cells was calculated by a multiplication of its proportion and the total cell number.
2. Results
The results are shown in FIG. 4. As shown in the figure, the compound (I-963) of the present invention significantly suppresses increasing number of eosinophils and neutrophils by the challenge of antigen.
Experiment 8 Suppressive Effect on the Cytokine Production of a Mouse T cell Strain EL-4
In 48-well plate were added 2×105 mouse T cell strain EL-4 which were suspended in 0.2 ml of 1% fetal bovine serum-added RPMI 1640 medium (2 mM of sodium bicarbonate, 50 units/ml of penicillin, 50 μg/ml of streptomycin and 5×10–5 M of 2mercaptoethanol were added) and the compound of the present invention of a pre-determined concentration. TPA was added as a cell stimulater at a final concentration of 10 ng/ml to adjust a final volume of each well to 0.4 ml. Each compound of the present invention was dissolved in DMSO and diluted with the above RPMI 1640 medium, and then for added at a final concentration of 100 ng/ml or less. The cells in the 48-well plate were cultivated in an incubator keeping the humidity 100%, carbon dioxide 5% and air 95% at 37° C. for 24 hours to collect a supernatant of each well. The amount of IL-2, IL-4 and IL-5 released in the medium of each well were measured with the ELISA kit (Amersham K. K.) to be taken as an index of the cytokine production of the cells. TPA free group (-TPA) was used as a control. The results are shown in Table 334.









TABLE 334









IC50 (ng/ml)












Compound
IL-2
IL-4
IL-5
















I-4
>500
14
120



I-37
>500
7
110



I-39
1300
7
130



I-70
>2000
0.2
1000



I-73
500
20
15



I-83
>10000
140
1000



I-128
>10000
140
450



I-148
>10000
100
11000



I-157
>10000
170
>10000



I-189
>10000
100
10000



I-190
>100
7
10



I-202
>2000
<20
<20



I-209
>200
14
12



I-213
>1000
25
23



I-218
>1000
4.8
30



I-220
>1000
150
720



I-223
1000
16
45



I-226
880
17
300



I-228
>1000
21
30



I-229
>1000
42
80



I-230
>1000
13
20



I-231
>500
9.6
9.2



I-233
>1000
12
3.8



I-237
>100
17
100



I-238
>1000
35
>1000



I-239
>1000
54
900



I-242
>1000
100
880



I-243
>500
63
>550



I-279
>1000
38
90



I-282
>500
<5
130



I-292
>1000
72
600



I-296
>1000
70
47



I-301
500
<10
120



I-302
>1000
25
280



I-305
>1000
10
340



I-307
>1000
52
23



I-309
>500
29
10



I-318
>1000
68
58



I-323
>1000
230
24



I-368
>1000
72
380



I-375
>1000
200
>1000



I-379
>1000
88
>1000



I-386
>1000
68
40



I-387
>1000
75
40



I-390
>1000
200
160



I-392
>1000
50
>1000



I-395
>1000
1–10
>1000



I-403
>1000
13
>1000



I-720
>500
6
110




















Formulation Example 1



















The compound of the present invention
15
mg



Starch
15
mg



Lactose
15
mg



Crystalline cellulose
19
mg



Polyvinyl alcohol
3
mg



Distilled water
30
ml



Calcium stearate
3
mg










After all of the above ingredients except for calcium stearate were uniformly mixed, the mixture was crushed and granulated, and dried to obtain a suitable size of granules. After calcium stearate was added to the granules, tablets were formed by compression molding.
INDUSTRIAL APPLICABILITY
As indicated in the above experiments, the compound of the present invention has a potent immunosuppressive and/or anti-allergic activity. The compound of the present invention and a substance which has the same activity as the compound of the present invention are very useful for a selective suppressor of the IgE production, an immunosuppressive agent and/or an anti-allergic agent.

## Claims

1. A selective suppressor of the IgE production comprising a compound of the formula (I′′):




wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12 and R13 are each independently hydrogen, hydroxy, halogen, carboxy, optionally substituted lower alkyl, optionally substituted lower alkoxy, optionally substituted lower alkenyl, optionally substituted lower alkenyloxy, optionally substituted lower alkylthio, optionally substituted lower alkoxycarbonyl, optionally substituted acyloxy, optionally substituted lower alkylsulfonyl, optionally substituted lower alkylsulfonyloxy, optionally substituted lower alkylsulfinyl, nitro, cyano, formyl, optionally substituted amino, optionally substituted carbamoyl, optionally substituted sulfamoyl or optionally substituted heterocyclyl,
X is —O—, —CH2—, —NR14— wherein R14 is hydrogen, optionally substituted lower alkyl, optionally substituted lower alkenyl or acetyl, or —S(O)p-wherein p is an integer of 0 to 2,
Y is optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl, optionally substituted acyl, optionally substituted cycloalkyl, optionally substituted cycloalkenyl, optionally substituted aryl or optionally substituted heterocyclyl, and Y may optionally be substituted lower alkoxy when X is —CH2— and may optionally be substituted lower alkoxycarbonyl, optionally substituted lower alkylsulfonyl or optionally substituted arylsulfonyl when X is —O— or —NR14—,
R1 and R4, R1 and R2, R2 and R3, R4 and R5, R6 and R7, R8 and R9, R10 and R11, R12 and R13, R11 and —X—Y, or R13 and —X—Y taken together may form a 5- or 6-membered ring which may contain one or more of O, S or NR15 wherein R15 is hydrogen, optionally substituted lower alkyl, optionally substituted lower alkenyl or optionally substituted arylsulfonyl and which may optionally be substituted, excluding a compound of the formula (I′):





wherein R1′ is hydrogen or hydroxy and R13′ is hydroxy or methoxy; or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.