# Patent

## Title
(P-amino-hydroxyphenyl)-acrylamide derivatives and dyes containing said compounds

## Abstract

The object of the invention are (p-aminohydroxyphenyl)acrylamide derivatives of general formula (I) or the physiologically tolerated, water-soluble salts thereof 




and oxidative coloring agents for keratin fibers, containing these compounds.

## Background
BACKGROUND OF THE INVENTION
1. Field of the Invention
The invention relates to new (p-aminohydroxyphenyl)acrylamide derivatives and dyeing agents containing these compounds for dyeing keratin fibers, particularly human hair.
2. Description of the Related Art
In the area of keratin fiber dyeing, particularly hair dyeing, oxidation dyes have attained substantial importance. In this case, the coloration is produced by reaction of certain developers with certain couplers in the presence of an appropriate oxidant. Suitable developers are, in particular, 2,5-diaminotroluene, 2,5-diaminophenylethyl alcohol, p-aminophenol, 1,4-diaminobenzene and 4,5-diaminopyrazole-1-(2′-hydroxyethyl)-pyrazole, and suitable couplers are, for example, resorcinol, 2-methylresorcinol, 1-naphthol, 3-aminophenol, m-phenylenediamine, 2-amino-4-(2′-hydroxyethyl)aminoanisole, 1,3-diamino-4-(2′-hydroxyethoxy)benzene and 2,4-diamino-5-fluorotoluene.
The oxidation dyes used for dyeing human hair must meet numerous requirements in addition to that of being able to produce colorations of the desired intensity. For example, these dyes must be harmless from a toxicological and dermatological standpoint, and the hair colorations obtained must have good light fastness, resistance to permanent waving, acid fastness and rubbing fastness. In any case, however, in the absence of exposure to light, rubbing and chemicals, such colorations must remain stable over a period of at least 4 to 6 weeks. Moreover, by combining appropriate developers and couplers, it must be possible to create a wide range of different color shades.
To attain natural and, in particular, fashionable color shades in the red region, p-aminophenol, alone or in admixture with other developers, in combination with suitable couplers, is primarily used. Attempts have already been made to improve the properties of p-aminophenols by the introduction of substituents. In this regards, the reader is referred to German Unexamined Patent Application DE 196 07 751 which describes colorants containing as developers special substituted p-aminophenol derivatives, for example 5-amino-2-hydroxycinnamic acid.
With the currently known colorants, it is not possible, however, to meet the requirements placed on colorants in all respects. Hence, the need continued to exist for new developers capable of meeting the aforesaid requirements to a particularly high degree.
SUMMARY OF THE INVENTION
Surprisingly, in this respect we have now found that new (p-aminohydroxyphenyl)acrylamide derivatives of general formula (I) meet said requirements placed on developers to a particularly high degree. In fact, when these developers are used with most known couplers, they give intense color shades that are unusually light-fast and wash-fast.
The object of the present invention therefore are (p-aminohydroxyphenyl)acrylamide derivatives of general formula (I) or physiologically tolerated, water-soluble salts thereof 




wherein

    
    
        R1 denotes hydrogen, a halogen atom (F, Cl, Br, I), a C1-C4-alkyl group, a C1-C4-hydroxyalkyl group or a C1-C4-alkoxy group;
        R2 and R3 independently of each other denote hydrogen or a C1-C6-alkyl group;
        R4 and R5 independently of each other denote hydrogen, a C1-C2-alkoxy group, a C1-C6-alkyl group, an unsaturated C3-C6-alkyl group, a C2-C4-hydroxyalkyl group, a C3-C4-dihydroxyalkyl group, a C2-C4-aminoalkyl group, a C2-C4-dimethylaminoalkyl group, a C2-C4-acetylaminoalkyl group, a C2-C4-methoxyalkyl group, C2-C4-ethoxyalkyl group, a C1-C4-cyanoalkyl group, a C1-C4-carboxyalkyl group, a C1-C4-aminocarbonylalkyl group, a pyridylmethyl group, a furfuryl group, a thienylmethyl group, a hydrogenated furfuryl group a substituted pyridyl group, a group of formula (II) 




        a group of formula (III) 




        or a group of formula (IV) 




        or R4 and R5 together with the nitrogen atom form a ring of the following formula 




        R6 denotes hydrogen, a carboxy group or an aminocarbonyl group;
        R7 and R8 independently of each other denote hydrogen, a hydroxyl group, an aminocarbonyl group, a methylthiomethyl group, a phenyl-substituted or hydroxyl-substituted phenyl group or a group of formula 




        R9, R10, R11, R12 and R13 independently of each other denote hydrogen, a halogen atom (F, Cl, Br, I), a cyano group, a hydroxyl group, a C1-C4-alkoxy group, a C1-C4-hydroxyalkoxy group, a C1-C6-alkyl group, a C1-C4-alkyl thioether group, a mercapto group, a nitro group, an amino group, an alkylamino group, a C1-C4-hydroxyalkylamino group, a dialkylamino group, a di(C1-C4-hydroxyalkyl)amino group, a (C3-C4-dihydroxyalkyl)amino group, a (C1-C4-hydroxyalkyl)-C1-C4-alkylamino group, a trifluoromethyl group, a —C(O)H group, a —C(O)CH3— group, a —C(O)CF3 group, an —Si(CH3)3 group, a C1-C4-hydroxyalkyl group or a C3-C4 dihydroxyalkyl group, or two adjacent R9 to R13 groups form an —O—CH2—O— bridge;
        R14 denotes a C1-C4-alkyl group, a benzyl group or a C2-C4-hydroxyalkyl group;
        R15 denotes hydrogen or a C1-C6-alkyl group;
        R16 denotes hydrogen, a hydroxyl group, a carboxy group, an aminocarbonyl group or a hydroxymethyl group; and
        R17 denotes hydrogen or a C1-C6-alkyl group.
    
    


Suitable compounds of formula (I) are, for example, the following: 3-(5-amino-2-hydroxyphenyl)-N-cyclopropylacrylamide, 3-(5-amino-2-hydroxyphenyl)-N-propylacrylamide, 3-(5-amino-2-hydroxyphenyl)-1-pyrrolidin-1-ylpropenone, 3-(5-amino-2-hydroxyphenyl)-N-(2-methoxyethyl)acrylamide, 3-(5-amino-2-hydroxyphenyl)-1-morpholin-4-ylpropenone, 3-(5-amino-2-hydroxyphenyl)-N-(1-hydroxymethylpropyl)acrylamide, 3-(5-amino-2-hydroxyphenyl)-N-furan-2-ylmethylacrylamide, 3-(5-amino-2-hydroxyphenyl)-N-methoxy-N-methylacrylamide, 3-(5-amino-2-hydroxyphenyl)-1-(4-methylpiperazin-1-yl)propenone, 3-(5-amino-2-hydroxyphenyl)-1-(4-hydroxypiperidin-1-yl)-propenone, N-(2-acetylaminoethyl)-3-(5-amino-2-hydroxyphenyl)acrylamide, 3-(5-amino-2-hydroxyphenyl)-N-(2-morpholin-4-ylethyl)acrylamide, 3-(5-amino-2-hydroxyphenyl)-N-[3-(2-ketopyrrolidin-1-yl)propyl]acrylamide, N-allyl-3-(5-amino-2-hydroxyphenyl)acrylamide, 3-(5-amino-2-hydroxyphenyl)-N-(2-hydroxy-1-methylethyl)acryl-amide, 3-(5-amino-2-hydroxyphenyl)-N-[2-(5-nitropyridin-2-yl-amino)ethyl]acrylamide, N-(2-aminoethyl)-3-(5-amino-2-hydroxyphenyl)acrylamide, 3-(5-amino-2-hydroxyphenyl)-N-(3-imidazol-1-ylpropyl)acrylamide, 3-(5-amino-2-hydroxyphenyl)-N-(tetrahydrofuran-2-ylmethyl)acrylamide, 3-(5-amino-2-hydroxyphenyl)-N-(4-aminophenyl)acrylamide, N-[4-amino-2(3)-(2-hydroxyethyl)phenyl]-3-(5-amino-2-hydroxyphenyl)acrylamide, 3-(5-amino-2-hydroxyphenyl)-N-{4-[bis-(2-hydroxyethyl)amino]phenyl}acrylamide, 3-(5-amino-2-hydroxyphenyl)-N-(3-aminophenyl)acrylamide, N-[5-amino-2(4)-(2-hydroxyethoxy)phenyl]-3-(5-amino-2-hydroxyphenyl)acrylamide, 3-(5-amino-2-hydroxyphenyl)-N-[2-chloro-4-(2-hydroxyethylamino)-5-nitrophenyl]acrylamide, N-[4-amino-2-(2-hydroxyethyl)-2H-pyrazol-3-yl]-3-(5-amino-2-hydroxyphenyl)acrylamide, 3-(5-amino-2-hydroxyphenyl)-N-benzo[1,3]dioxol-5-ylacrylamide, 3-(5-amino-2-hydroxyphenyl)-N-(2-hydroxyethyl)-N-methylacrylamide, 3-(5-amino-2-hydroxyphenyl)-N-ethyl-N-(2-hydroxyethyl)acrylamide, 3-(5-amino-2-hydroxyphenyl)-1-(2-hydroxymethylpyrrolidin-1-yl)propenone, 1-[3-(5-amino-2-hydroxyphenyl)acryloyl]pyrrolidin-2-carboxamide, 3-(5-amino-2-hydroxyphenyl)-1-(3-hydroxypiperidin-1-yl)propenone, 3-(5-amino-2-hydroxyphenyl)-N-(2-hydroxy-1-hydroxymethylethyl)acrylamide, 3-(5-amino-2-hydroxyphenyl)-N-ethylacrylamide, 2-[3-(5-amino-2-hydroxyphenyl)acryloylamino]-3-methylbutyric acid, 3-(5-amino-2-hydroxyphenyl)-N-(4-hydroxyphenyl)acrylamide, 3-(5-amino-2-hydroxyphenyl)-N-(1-carbamoyl-2-hydroxyethyl)acrylamide, 3-(5-amino-2-hydroxyphenyl)-N-(4-amino-2(3)-methylphenyl)acrylamide, 3-(5-amino-2-hydroxyphenyl)-N-(3-hydroxy-4-methylphenyl)acrylamide, 3-(5-amino-2-hydroxyphenyl)-N-(2-hydroxy-5-nitrophenyl)acrylamide, 3-(5-amino-2-hydroxyphenyl)acrylic acid, 3-(2-amino-5-hydroxyphenyl)-N-cyclopropylacrylamide, 3-(2-amino-5-hydroxyphenyl)-N-propylacrylamide, 3-(2-amino-5-hydroxyphenyl)-1-pyrrolidin-1-ylpropenone, 3-(2-amino-5-hydroxyphenyl)-N-(2-methoxyethyl)acrylamide, 3-(2-amino-5-hydroxyphenyl)-1-morpholin-4-ylpropenone, 3-(2-amino-5-hydroxyphenyl)-N-(1-hydroxymethylpropyl)acrylamide, 3-(2-amino-5-hydroxyphenyl)-N-furan-2-ylmethylacrylamide, 3-(2-amino-5-hydroxyphenyl)-N-methoxy-N-methylacrylamide, 3-(2-amino-5-hydroxyphenyl)-1-(4-methylpiperazin-1-yl)-propenone, 3-(2-amino-5-hydroxyphenyl)-1-(4-hydroxypiperidin-1-yl)propenone, N-(2-acetylaminoethyl)-3-(2-amino-5-hydroxyphenyl)acrylamide, 3-(2-amino-5-hydroxyphenyl)-N-(2-morpholin-4-ylethyl)acrylamide, 3-(2-amino-5-hydroxyphenyl)-N-[3-(2-ketopyrrolidin-1-yl)propyl]acrylamide, N-allyl-3-(2-amino-5-hydroxyphenyl)acrylamide, 3-(2-amino-5-hydroxyphenyl)-N-(2-hydroxy-1-methylethyl)acrylamide, 3-(2-amino-5-hydroxyphenyl)-N-[2-(5-nitropyridin-2-ylamino)ethyl]acrylamide, N-(2-aminoethyl)-3-(2-amino-5-hydroxyphenyl)acrylamide, 3-(2-amino-5-hydroxyphenyl)-N-(3-imidazol-1-ylpropl)acrylamide, 3-(2-amino-5-hydroxyphenyl)-N-(tetrahydrofuran-2-ylmethyl)acrylamide, 3-(2-amino-5-hydroxyphenyl)-N-aminophenyl)acrylamide, N-[4-amino-2(3)-(2-hydroxyethyl)phenyl]-3-(2-amino-5-hydroxyphenyl)acrylamide, 3-(2-amino-5-hydroxyphenyl)-N-{4-[bis-(2-hydroxyethyl)amino]phenyl}acrylamide, 3-(2-amino-5-hydroxyphenyl)-N-(3-aminophenyl)acrylamide, N-[5-amino-2-(4)-(2-hydroxyethoxy)phenyl]-3-(2-amino-5-hydroxyphenyl)acrylamide, 3-(2-amino-5-hydroxyphenyl)-N-[2-chloro-4-(2-hydroxyethylamino)-5-nitrophenyl]-acrylamide, N-[4-amino-2-(2-hydroxyethyl)-2H-pyrazol-3-yl]-3-(2-amino-5-hydroxyphenyl)acrylamide, 3-(2-amino-5-hydroxyphenyl)-N-benzo[1,3]dioxol-5-ylacrylamide, 3-(2-amino-5-hydroxyphenyl)-N-(2-hydroxyethyl)-N-methylacrylamide, 3-(2-amino-5-hydroxyphenyl)-N-ethyl-N-(2-hydroxyethyl)acrylamide, 3-(2-amino-5-hydroxyphenyl)-1-(2-hydroxymethylpyrrolidin-1-yl)propenone, 1-[3-(2-amino-5-hydroxyphenyl)acryloyl]pyrrolidin-2-carboxamide, 3-(2-amino-5-hydroxyphenyl)-1-(3-hydroxypiperidin-1-yl)propenone, 3-(2-amino-5-hydroxyphenyl)-N-(2-hydroxy-1-hydroxymethylethyl)acrylamide, 3-(2-amino-5-hydroxyphenyl)-N-ethylacrylamide, 2-[3-(2-amino-5-hydroxyphenyl)acryloylamino]-3-methylbutyric acid, 3-(2-amino-5-hydroxyphenyl)-N-(4-hydroxyphenyl)acrylamide, 3-(2-amino-5-hydroxyphenyl)-N-(1-carbamoyl-2-hydroxyethyl)acrylamide, 3-(2-amino-5-hydroxyphenyl)-N-(4-amino-2(3)-methylphenyl)acrylamide, 3-(2-amino-5-hydroxyphenyl)-N-(3-hydroxy-4-methylphenyl)acrylamide, 3-(2-amino-5-hydroxyphenyl)-N-(2-hydroxy-5-nitrophenyl)acrylamide and 3-(2-amino-5-hydroxyphenyl)acrylic acid and the physiologically tolerated salts thereof.
Preferred compounds of formula (I) are those wherein (i) one, several or all R1, R2 and R3 groups denote hydrogen and/or (ii) R4 denotes a C1-C2-alkyl group, a methoxy group or a C2-C4-hydroxyalkyl group and R5 denotes a C2-C4-hydroxyalkyl group and/or (iii) R4 and R5 independently of each other denote hydrogen, a C1-C4-alkyl group, an unsaturated C1-C6-alkyl group, a C2-C4-hydroxyalkyl group, a C3-C4-dihydroxyalkyl group, a furfuryl group a substituted phenyl group of formula (III) or a substituted pyrazolyl group of formula (IV) and/or (iv) R4 denotes hydrogen and R5 denotes a C1-C4-alkyl group, an unsaturated C3-C6-alkyl group, a C2-C4-hydroxyalkyl group, a C3-C4-dihydroxyalkyl group, a furfuryl group, a substituted phenyl group of formula (III) or a substituted pyrazolyl group of formula (IV).
Particularly preferred are the following compounds of formula (I): 3-(5-amino-2-hydroxyphenyl)-N-ethylacrylamide, 3-(2-amino-5-hydroxyphenyl)-N-ethylacrylamide, 3-(5-amino-2-hydroxyphenyl)-N-(4-hydroxyphenyl)acrylamide, 3-(2-amino-5-hydroxyphenyl)-N-(4-hydroxyphenyl)acrylamide, 3-(5-amino-2-hydroxyphenyl)-N-(4-aminophenyl)acrylamide, 3-(2-amino-5-hydroxyphenyl)-N-(4-aminophenyl)acrylamide, N-[4-amino-2-(2-hydroxyethyl)-2H-pyrazol-3-yl]-3-(5-amino-2-hydroxyphenyl)acrylamide and N-[4-amino-2-(2-hydroxyethyl)-2H-pyrazol-3-yl]-3-(2-amino-5-hydroxyphenyl)acrylamide and the physiologically tolerated salts thereof.
The compounds of formula (I) can be used as the free bases as well as in the form of their physiologically tolerated salts with inorganic or organic acids, for example hydrochloric acid, sulfuric acid, phosphoric acid, acetic acid, propionic acid, lactic acid or citric acid.
The aminophenol derivatives of formula (I) of the invention can be prepared by methods of synthesis known from the literature. For example, the synthesis of the compounds of the invention can be carried out as follows:

by aminolysis of a substituted benzene of formula (V) 




with an amine of formula NHR4R5 followed by elimination of the protective group and/or reduction of the nitro group,

wherein Ra stands for an appropriate protective group as described, for example, in Organic Synthesis, Chapter 3, “Protection for Phenols”, p, 143 ff, Wiley Interscience, 1991; Rb stands for NHRa or NO2, R18 denotes a carboxylic acid group, a carboxylic acid chloride group, a carboxylate ester group or a carboxylic anhydride group, and the R1, R2, R3, R4 and R5 group have the same meaning as in formula (I).
The compounds of formula (I) of the invention can be used, in particular, as developers in oxidative colorants for keratin fibers. They make it possible to produce a wide range of different color shades going from blond to brown to purple and all the way to violet shades.
Another object of the invention are therefore agents for oxidative dyeing of keratin fibers, for example hair, furs, feathers or wool, particularly human hair, based on a developer-coupler combination, which as developer contain at least one (p-aminohydroxyphenyl)acrylamide derivative of formula (I).
The colorant of the invention contains the aminophenol derivative of formula (I) in an amount from about 0.005 to 20 weight percent, an amount of about 0.01 to 5.0 weight percent and particularly 0.1 to 2.5 weight percent being preferred.
Preferred couplers are N-(3-dimethylaminophenyl)urea, 2,6-diaminopyridine, 2-amino-4-[(2-hydroxyethyl)amino]anisole, 2,4-diamino-1-fluoro-5-methylbenzene, 2,4-diamino-1-methoxy-5-methylbenzene, 2,4-diamino-1-ethoxy-5-methylbenzene, 2,4-diamino-1-(2-hydroxyethoxy)-5-methylbenzene, 2,4-di[(2-hydroxyethyl)amino]-1,5-dimethoxybenzene, 2,3-diamino-6-methoxypyridine, 3-amino-6-methoxy-2-(methylamino)pyridine, 2,6-diamino-3,5-dimethoxypyridine, 3,5-diamino-2,6-dimethoxypyridine, 1,3-diaminobenzene, 2,4-diamino-1-(2-hydroxyethoxy)benzene, 1,3-diamino-4-(2,3-dihydroxypropoxy)benzene, 1,3-diamino-4-(3-hydroxypropoxy)benzene, 1,3-diamino-4-(2-methoxyethoxy)benzene, 2,4-diamino-1,5-di(2-hydroxyethoxy)benzene, 1-(2-aminoethoxy)-2,4-diaminobenzene, 2-amino-1-(2-hydroxyethoxy)-4-methylaminobenzene, 2,4-diaminophenoxyacetic acid, 3-[di(2-hydroxyethyl)amino]aniline, 4-amino-2-di[(2-hydroxyethyl)amino]-1-ethoxybenzene, 5-methyl-2-1-methylethyl)phenol, 3-[(2-hydroxyethyl)amino]aniline, 3-[(2-aminoethyl)amino]aniline, 1,3-di(2,4-diaminophenoxy)propane, di(2,4-diaminophenoxy)methane, 1,3-diamino-2,4-dimethoxybenzene, 2,6-bis-(2-hydroxyethyl)aminotoluene, 4-hydroxyindole, 3-dimethylaminophenol, 3-diethylaminophenol, 5-amino-2-methylphenol, 5-amino-4-fluoro-2-methylphenol, 5-amino-4-methoxy-2-methylphenol, 5-amino-4-ethoxy-2-methylphenol, 3-amino-2,4-dichlorophenol, 5-amino-2,4-dichlorophenol, 3-amino-2-methylphenol, 3-amino-2-chloro-6-methylphenol, 3-aminophenol, 2-[(3-hydroxyphenyl)amino]acetamide, 5-[(2-hydroxyethyl)amino]-4-methoxy-2-methylphenol, 5-[(2-hydroxyethyl)amino]-2-methylphenol, 3-[(2-hydroxyethyl)amino]phenol, 3-[(2-methoxyethyl)amino]phenol, 5-amino-2-ethylphenol, 5-amino-2-methoxyphenol, 2-(4-amino-2-hydroxyphenoxy)ethanol, 5-[(3-hydroxypropyl)amino]-2-methylphenol, 3-[(2,3-dihydroxypropyl)amino]-2-methylphenol, 3-[(2-hydroxyethyl)amino]-2-methylphenol, 2-amino-3-hydroxypyridine, 2,6-dihydroxy-3,4-dimethylpyridine, 5-amino-4-chloro-2-methylphenol, 1-naphthol, 2-methyl-1-naphthol, 1,5-dihydroxynaphthalene, 1,7-dihydroxynaphthalene, 2,3-dihydroxynaphthalene, 2,7-dihydroxynaphthalene, 2-methyl-1-naphthol acetate, 1,3-dihydroxybenzene, 1-chloro-2,4-dihydroxybenzene, 2-chloro-1,3-dihydroxybenzene, 1,2-dichloro-3,5-dihydroxy-4-methylbenzene, 1,5-dichloro-2,4-dihydroxybenzene, 1,3-dihydroxy-2-methylbenzene, 3,4-methylenedioxyphenol, 3,4-methylenedioxyaniline, 5-[(2-hydroxyethyl)amino]-1,3-benzodioxole, 6-bromo-1-hydroxy-3,4-methylenedioxybenzene, 3,4-diaminobenzoic acid, 3,4-dihydro-6-hydroxy-1,4(2H)benzoxazine, 6-amino-3,4-dihydro-1,4[2H]benzoxazine, 3-methyl-1-phenyl-5-pyrazolone, 5,6-dihydroxyindole, 5,6-dihydroxyindoline, 5-hydroxyindole, 6-hydroxyindole, 7-hydroxyindole and 2,3-indolinedione.
Although the advantageous properties of the aminophenol derivatives of formula (I) described herein suggest that they alone be used as developers, it is, of course, also possible to use the p-aminophenol derivatives of formula (I) together with other known developers, for example with 1,4-diaminobenzene, 2,5-diaminotoluene, 2-(2,5-diaminophenyl)ethyl alcohol, 1-(2,5-diaminophenyl)ethyl alcohol, N,N-bis-(2′-hydroxyethyl)-1,4-diaminobenzene, 4-aminophenol and the derivatives thereof, for example 4-amino-3-methylphenol, pyrazole derivatives, for example 4,5-diamino-1-(2-hydroxyethyl)pyrazole, 4,5-diamino-1-benzylpyrazole and 4,5-diamino-1-(4-methylbenzyl)pyrazole, or tetraaminopyrimidines.
The couplers and developers can be present in the colorant of the invention either individually or in admixture with one another, the total amount of each of the couplers and developers in the colorant of the invention being about 0.005 to 20 wt. % preferably about 0.01 to 5 wt. % and particularly 0.1 to 2.5 wt. % (based on the total amount of colorant).
The total amount of the developer-coupler combination contained in the colorant described herein is preferably about 0.01 to 20 wt. %, an amount of about 0.02 to 10 wt. % and especially 0.2 to 6.0 wt. % being particularly preferred. In general, the developers and couplers are used in approximately equimolar amounts. In this respect, it is not disadvantageous, however, if the developers are present in a certain excess or deficiency.
Moreover, the colorant of the invention can also contain other dye components, for example 6-amino-2-methylphenol and 2-amino-5-methylphenol, as well as common direct dyes, for example triphenylmethane dyes such as 4-[(4′-aminophenyl)-(4′-imino-2′′,5′′-cyclohexadien-1′′-ylidene)methyl]-2-methylaminobenzene monohydrochloride (Color Index [C.I.] 42 510) and 4-[(4′-amino-3′-methylphenyl)-(4′′-imino-3′′-methyl-2′′,5′′-cyclohexadien-1′′-ylidene)methyl]-2-methylaminobenzene monohydrochloride (C.I. 42 520), aromatic nitro dyes such as 4-(2′-hydroxyethyl)aminonitrotoluene, 2-amino-4,6-dinitrophenol, 2-amino-5-(2′-hydroxyethyl)aminonitrobenzene, 2-chloro-6-(ethylamino)-4-nitrophenol, 4-chloro-N-(2-hydroxyethyl)-2-nitroaniline, 5-chloro-2-hydroxy-4-nitroaniline, 2-amino-4-chloro-6-nitrophenol and 1-(2′-ureidoethyl)amino-4-nitrobenzene, azo dyes such as sodium 6-[(4′-aminophenyl)azo]-5-hydroxynaphthalene-1-sulfonate (C.I. 14 805) and disperse dyes, for example 1,4-diaminoanthraquinone and 1,4,5,8-tetraaminoanthraquinone. The colorants of the invention can contain the aforesaid dye components in an amount from about 0.1 to 4 wt. %.
The couplers and developers as well as the other dye components, provided they are bases, can, of course, also be used in the form of their physiologically tolerated salts with organic or inorganic acids, for example hydrochloric acid or sulfuric acid, or—if they contain aromatic OH groups—in the form of their salts with bases, for example as alkali metal phenoxides.
Moreover, if the colorants are to be used for coloring hair, they can also contain other common cosmetic additives, for example antioxidants such as ascorbic acid, thioglycolic acid or sodium sulfite, as well as perfume oils, complexing agents, wetting agents, emulsifiers, thickeners and hair-care agents.
The colorant of the invention can be in the form of, for example, a solution, particularly an aqueous or aqueous-alcoholic solution. A particularly preferred formulation form, however, is a cream, gel or emulsion. Such a composition consists of a mixture of the dye components and the usual additives employed for such compositions.
Common additives to solutions, creams, emulsions or gels are, for example solvents such as water, lower aliphatic alcohols, for example ethanol, propanol or isopropanol, glycerol or glycols such as 1,2-propylene glycol, moreover wetting agents or emulsifiers from the classes of anionic, cationic, amphoteric or nonionic surface-active agents, for example fatty alcohol sulfates, ethoxylated fatty alcohol sulfates, alkylsulfonates, alkylbenzenesulfonates, alkyltrimethylammonium salts, alkylbetaines, ethoxylated fatty alcohols, ethoxylated nonylphenols, fatty acid alkanolamides and ethoxylated fatty esters, furthermore thickeners such as the higher fatty alcohols, starch, cellulose derivatives, petrolatum, paraffin oil and fatty acids, also hair-care agents such as cationic resins, lanolin derivatives, cholesterol, pantothenic acid and betaine. The said constituents are used in amounts commonly employed for such purposes, for example the wetting agents and emulsifiers at a concentration of about 0.5 to 30 wt. %, the thickeners in an amount from about 0.1 to 30 wt. % and the hair-care agents at a concentration from about 0.1 to 5 wt. %.
Depending on the composition, the colorant of the invention can be weakly acidic, neutral or alkaline. In particular, it can have a pH of about 6.5 to 11.5. The adjustment to a basic pH is preferably made with ammonia, but it can also be made with an organic amine, for example with monoethanolamine and triethanolamine, or with an inorganic base such as sodium hydroxide and potassium hydroxide. The adjustment to an acidic pH can be made with an inorganic or organic acid, for example phosphoric, acetic, citric or tartaric acid.
For oxidative dyeing of hair, the afore-described colorant is mixed with an oxidant just before use, and an amount sufficient for hair treatment, generally about 60 to 200 grams, of this mixture, depending on the hair fullness, is applied to the hair.
Suitable oxidants for developing the hair coloration are primarily hydrogen peroxide or its products of addition to urea, melamine, sodium borate or sodium carbonate in the form of a 3 to 12% and preferably 6% aqueous solution, atmospheric oxygen also being suitable. When a 6% hydrogen peroxide solution is used as oxidant, the weight ratio of hair colorant to oxidant is from 5:1 to 1:2 and preferably 1:1. Higher amounts of oxidant are used especially with higher dye concentrations in the hair colorant or when stronger bleaching of the hair is wanted at the same time. The mixture is allowed to act on the hair at 15 to 50° C. for about 10 to 45 minutes, preferably 30 minutes. The hair is then rinsed with water and dried. Optionally, following this rinsing, the hair is washed with a shampoo and optionally post-rinsed with a weak organic acid such as citric acid or tartaric acid. The hair is then dried.
The colorants of the invention containing a p-aminophenol derivative of formula (I) as developer give hair colorations of excellent color stability, particularly in terms of light fastness, wash fastness and rubbing fastness. As far as the dyeing properties are concerned, the hair colorants of the invention provide a wide range of different color shades from blond to brown to purple, violet and even blue and black, depending on the kind and composition of the dye components used. The shades stand out by their unusual color intensity and good color balancing between damaged and un-damaged hair. The very good coloring properties of the hair colorants of the present patent application also manifest themselves in that these colorants make it possible to dye gray hair, previously not damaged chemically, without any problems and with good covering power.
The following examples illustrate the object of the invention in greater detail without limiting its scope.


EXAMPLES
Example 1
Synthesis of (p-Aminohydroxyphenyl)acrylamide Derivatives of Formula (I) (General Method of Synthesis)
A. Synthesis of tert.butyl N-(3-bromo-4-hydroxyphenyl)carbamate
A solution of 9.4 g (52.8 mmol) of N-bromosuccinimide in 450 mL of chloroform was added dropwise at 0° C. over a period of 2 hours to a suspension of 10 g (47.8 mmol) of tert.butyl N-(4-hydroxyphenyl)carbamate in 100 mL of chloroform. The reaction mixture was allowed to agitate for an additional 15 min after which it was washed twice with water (first with 400 ml, then with 200 mL), dried with magnesium sulfate and filtered, and the filtrate was partly evaporated. Hexane was then added to the residue with agitation, which caused a precipitate to form. The precipitate was filtered off and washed with hexane.
This gave 9.7 g (70% of the theoretical) of tert.butyl N-(3-bromo-4-hydroxyphenyl)carbamate.
B. Synthesis of tert.butyl N-(3-bromo-4-ethoxymethoxyphenyl)carbamate
0.76 g (17.4 mmol) of a sodium hydride dispersion (55% in oil) was added portionwise at 0° C. to a solution of 5 g (17.4 mmol) of tert.butyl N-(3-bromo-4-hydroxyphenyl)carbamate in 60 mL of tetrahydrofuran. The mixture was allowed to agitate 50 min at 0° C. after which 1.83 g (19.4 mmol) of chloromethyl ethyl ether was added. The mixture was allowed to agitate at 0° C. for an additional hour. It was then poured onto ice and extracted with ethyl acetate, and the organic phase was washed with a saturated aqueous sodium chloride solution, dried over Na2SO4 and filtered, and the filtrate was evaporated. The residue was purified on silica gel with petroleum ether/ethyl acetate (9:1).
This gave 4.8 g (80% of the theoretical) of tert.butyl N-(3-bromo-4-ethoxymethoxyphenyl)carbamate.
1H-NMR (300 MHz, CDCl3): δ=7.67 (d, 1H); 7.16 (dd, 1H); 7.07 (d, 1H); 5.23 (s, 2H); 3.77 (q, 2H); 1.51 (s, 9H); 1.22 (t, 3H).
C. Synthesis of tert.butyl N-(4-ethoxymethoxy-3-formylphenyl)carbamate
3.3 g (0.01 mol) of tert.butyl (3-bromo-4-ethoxy-methoxyphenyl)-carbamate from step B was dissolved under argon in 100 mL of anhydrous tetrahydrofuran. Then, 17 mL (=0.03 mol) of a 1.6-molar solution of methyllithium in ether was added stepwise. The reaction mixture was then cooled to −20° C., and to it was added stepwise 7 mL (=0.01 mol) of a 1.5-molar solution of tert.butyl-lithium. At the end of the addition, the solution was allowed to agitate for an additional 30 min at the indicated temperature. Then, 1.2 g (0.02 mol) of dimethylformamide was added, and the reaction mixture was allowed to agitate at −20° C. for 1 hour. It was then heated slowly to 0° C. and hydrolyzed with a 10% phosphate buffer solution and poured onto ethyl acetate. The aqueous phase was extracted with ethyl acetate, and the organic phase was dried with magnesium sulfate. The solvent was distilled off in a rotary evaporator, and hexane was added to the residue. The resulting yellow precipitate was then filtered off, washed with hexane and dried.
This gave 2.0 g (70% of the theoretical) of tert.butyl N-(4-ethoxymethoxy-3-formylphenyl)carbamate.
1H-NMR (300 MHz, CDCl3): δ=10.43 (s, 1H); 7.73 (d 1H); 7.61 (d, 1H); 7.20 (d, 1H); 6.45 (br, 1H); 5.31 (s, 2H); 3.75 (q, 2H); 1.51 (s, 9H); 1.23 (t, 3H).
D. Synthesis of methyl 3-(5-tert.butoxycarbonylamino-2-ethoxymethoxyphenyl)acrylate
8.9 g (0.03 mol) of tert.butyl N-(ethoxymethoxy-2-formylphenyl)carbamate from step C was dissolved in 70 mL of tetrahydrofuran and to the resulting solution was added 11.9 g (0.036 mol) of methoxycarbonylmethylene triphenylphosphorane. The reaction mixture was allowed to agitate 3 hours at room temperature. The mixture was then poured into water and extracted with ethyl acetate, and the organic phase was washed with saturated aqueous sodium chloride solution, dried over sodium sulfate and filtered, and the filtrate was evaporated.
Flash chromatography of the crude product on silica gel with hexane/ethyl acetate gave 10.5 g (95% of the theoretical) of product. The product was suspended in hexane/diethyl ether (10:1), and the pure E-isomer was obtained by crystallization from ethyl acetate/hexane.
1H-NMR (300 MHz, CDCl3): δ=7.99 (d, 1H); 7.60 (br s, 1H); 7.26 (dd, 1H); 7.12 (d, 1H); 6.50 (d, 1H); 6.42 (br s, 1H); 5.25 (s, 2H); 3.79 (s, 3H); 3.73 (q, 2H); 1.51 (s, 9H); 1.21 (t, 3H).
E. Synthesis of 3-(5-tert.butoxycarbonylamino-2-ethoxymethoxyphenyl)acrylic acid
2.53 g (0.06 mol) of lithium hydroxide monohydrate was added at 0° C. to a solution of 6.3 g (0.018 mol) of methyl 3-(5-tert.butoxycarbonylamino-2-ethoxymethoxyphenyl)acrylate from step D in 50 mL of tetrahydrofuran, 15 mL of methanol and 30 mL of water. The mixture was allowed to agitate 24 hours at 60° C. The reaction mixture was then poured onto a phosphate buffer solution (pH 7.0) and extracted with ethyl acetate, and the organic phase was washed with a saturated aqueous sodium chloride solution and then dried over sodium sulfate. The organic phase was partially evaporated to incipient formation of a precipitate, and hexane was then added. The precipitate was filtered off and washed with 50 mL of hexane. This gave 5.4 g (89% of the theoretical) of 3-(5-tert.butoxycarbonylamino-2-ethoxymethoxyphenyl)acrylic acid.
1H-NMR (300 MHz, DMSO-D6): δ=12.4 (br, 1H); 9.22 (br s, 1H); 7.81 (d, 1H); 7.73 (d, 1H); 7.42 (dd, 1H); 7.10 (d, 1H); 6.33 (d, 1H); 5.27 (s, 2H); 3.67 (q, 2H); 1.48 (s, 9H); 1.13 (t, 3H).
F. Synthesis of 3-(5-amino-2-hydroxyphenyl)acrylamide derivatives
A mixture of 0.07 g (0.185 mmol) of 3-(5-tert.butoxycarbonylamino-2-ethoxymethoxyphenyl)acrylic acid, 0.037 g (0.24 mmol) of N-hydroxybenzotriazole hydrate and 0.043 g (0.22 mmol) of N-(3-dimethylaminopropyl-N′-ethylcarbodiimide hydrochloride in dichloromethane was charged to a reactor. To it were added the appropriate amine (0.22 mol) and 0.047 g of N-ethyldiisopropylamine, and the mixture was allowed to shake for 12 hours at room temperature. At the end of the reaction, the reaction mixture was poured into 10 mL of ethyl acetate. The organic phase was then ex-tracted with sodium hydrogen carbonate and dried with magnesium sulfate. The sol-vent was distilled off in a rotary evaporator and the residue was purified on silica gel with an appropriate eluent (for example, petroleum ether/ethyl acetate or dichloro-methane/methanol). The resulting product in 4 mL of ethanol was heated to 50° C. To prepare the hydrochloride, 1.5 mL of a 2.9-molar ethanolic hydrochloric acid solution was added dropwise. The solution was evaporated, and the residue was dried.
a. 3-(5-Amino-2-hydroxyphenyl)-N-ethylacrylamide hydrochloride
Amine used: ethylamine
Mass spectrum: MH+ 207 (100)
b. 3-(5-Amino-2-hydroxyphenyl)-N-(4-aminophenyl)acrylamide hydrochloride
Amine used: 4-hydroxy-1-aminobenzene
Mass spectrum: MH+ 271 (100)
c. 3-(5-Amino-2-hydroxyphenyl)-N-(4-aminophenyl)acrylamide hydrochloride
Amine used: tert.butyl 4-aminophenylcarbamate
Mass spectrum: MH+ 270 (100)
d. N-[4-Amino-2-(2-hydroxyethyl)-2H-pyrazol-3-yl]-3-(5-amino-2-hydroxyphenylyacrylamide hydrochloride
Amine used: 4,5-diamino-1-(2-hydroxyethyl)pyrazole
Mass spectrum: MH+ 269 (100)
e. N-Allyl-3-(5-amino-2-hydroxyhenyl)acrylamide hydrochloride
Amine used: allylamine
Mass spectrum: MH+ 304 (100)
f. 3-(5-Amino-2-hydroxyphenyl)-N-cylopropylacrylamide hydrochloride
Amine used: cyclopropylamine
Mass spectrum: MH+ 219 (100)
g. N-(2-Aminoethyl)-3-(5-amino-2-hydroxyphenyl)acrylamide hydrochloride
Amine used: ethylenediamine
Mass spectrum: MH+ 222 (100)
h. 3-(5-Amino-2-hydroxyphenyl)-N-[4-amino-2(3)-methylphenyl]acrylamide hydrochloride
Amine used: tert.butyl (4-amino-2-methylphenyl)carbamate and tert.butyl (4-amino-3-methylphenyl)carbamate
Mass spectrum: MH+ 284 (100)
i. 3-(5-Amino-2-hydroxyphenyl)-N-isopropylacrylamide hydrochloride
Amine used: isopropylamine
Mass spectrum: MH+ 221 (100)
j. 3-(5-Amino-2-hydroxyphenyl)-N-propylacrylamide hydrochloride
Amine used: propylamine
Mass spectrum: MH+ 221 (100)
k. 3-(5-Amino-2-hydroxyphenyl)-1-pyrrolidin-1-ylpropenone hydrochloride
Amine used: pyrrolidine
Mass spectrum: MH+ 233 (100)
l. 3-(5-Amino-2-hydroxyphenyl)-N-(2-methoxyethyl)acrylamide hydrochloride
Amine used: 2-methoxyethylamine
Mass spectrum: MH+ 237 (100)
m. 3-(5-Amino-2-hydroxyphenyl)-1-morpholin-4-ylpropenone hydrochloride
Amine used: morpholine
Mass spectrum: MH+ 249 (100)
n. 3-(5-Amino-2-hydroxyphenyl)-N-(1-hydroxymethylpropyl)acrylamide hydrochloride
Amine used: 2-amino-1-butanol
Mass spectrum: MH+ 251 (100)
o. 3-(5-Amino-2-hydroxyphenyl)-N-furan-2-ylmethylacrylamide hydrochloride
Amine used: furfurylamine
Mass spectrum: MH+ 259 (100)
p. 3-(5-Amino-2-hydroxyphenyl)-N-methoxy-N-methylacrylamide hydrochloride
Amine used: N,O-dimethylhydroxylamine hydrochloride
Mass spectrum: MH+ 223 (100)
q. 3-(5-Amino-2-hydroxyphenyl)-1-(4-methylpiperazin-1-yl)propenone hydrochloride
Amine used: 4-methylpiperazine
Mass spectrum: MH+ 262 (100)
r. 3-(5-Amino-2-hydroxyphenyl)-1-(4-hydroxypiperidin-1-yl)propenone hydrochloride
Amine used: 4-hydroxypiperidine
Mass spectrum: MH+ 263 (100)
s. N-(2-Acetylaminoethyl)-3-(5-amino-2-hydroxyphenyl)acrylamide hydrochloride
Amine used: N-acetylethylenediamine
Mass spectrum: MH+ 264 (100)
t. 3-(5-Amino-2-hydroxyphenyl)-N-(2-morpholin-4-ylethyl)acrylamide hydrochloride
Amine used: 4-(2-ethylamino)morpholine
Mass spectrum: MH+ 292 (100)
u. 3-(5-Amino-2-hydroxyphenyl)-N-[3-(2-ketopyrrolidin-1-yl)propyl]acrylamide hydrochloride
Amine used: 1-(3-aminopropyl)-2-pyrrolidone
Mass spectrum: MH+ 304 (100)
v. 3-(5-Amino-2-hydroxyphenyl)-N-(2-hydroxy-1-methylethyl)acrylamide hydrochloride
Amine used: 2-aminopropanol
Mass spectrum: MH+ 237 (100)
w. 3-(5-Amino-2-hydroxyphenyl)-N-[2-(5-nitropyridin-2-ylamino)ethyl]acrylamide hydrochloride
Amine used: 2-amino-5-nitropyridine
Mass spectrum: MH+ 344 (100)
x. 3-(5-Amino-2-hydroxyphenyl)-N-(3-imidazol-1-ylpropyl)acrylamide hydrochloride
Amine used: 1-(3-aminopropyl)imidazole
Mass spectrum: MH+ 287 (100)
y. 3-(5-Amino-2-hydroxyphenyl)-N-(tetrahydrofuran-2-ylmethyl)acrylamide hydrochloride
Amine used: tetrahydrofurfurylamine
Mass spectrum: MH+ 263 (100)
z. N-[4-Amino-2(3)-(2-hydroxyethyl)phenyl]-3-(5-amino-2-hydroxyphenyl)acrylamide hydrochloride
Amine used: tert.butyl [4-amino-2-(2-hydroxyethyl)phenyl]carbamate and tert.butyl [4-amino-3-(2-hydroxyethyl)phenyl]carbamate
Mass spectrum: MH+ 314 (100)
aa. 3-(5-Amino-2-hydroxyphenyl)-N-{4-[bis-(2-hydroxyethyl)amino]phenyl}acrylamide hydrochloride
Amine used: 4-bis-(2-hydroxyethyl)aminoaniline
Mass spectrum: MH+ 358 (100)
ab. 3-(5-Amino-2-hydroxyphenyl)-N-(3-aminophenyl)acrylamide hydrochloride
Amine used: tert.butyl (3-aminophenyl)carbamate
Mass spectrum: MH+ 270 (100)
ac. N-[5-Amino-2(4)-(2-hydroxyethoxy)phenyl]-3-(5-amino-2-hydroxyphenyl)acrylamide hydrochloride
Amine used: tert.butyl [3-amino-4-(2-hydroxyethoxy)phenyl]carbamate and tert.butyl [3-amino-6-(2-hydroxyethoxy)phenyl]carbamate
Mass spectrum: MH+ 330 (100)
ad. 3-(5-Amino-2-hydroxyphenyl)-N-[2-chloro-4-(2-hydroxyethylamino)-5-nitrophenyl]acrylamide hydrochloride
Amine used: 2-chloro-4-(2-hydroxyethyl)amino-5-nitroaniline
Mass spectrum: MH+ 393 (100)
ae. 3-(5-Amino-2-hydroxyphenyl)-N-benzo[1,3]dioxol-5-ylacrylamide hydrochloride
Amine used: benzo[1,3]dioxol-5-ylamine
Mass spectrum: MH+ 299 (100)
af. 3-(5-Amino-2-hydroxyphenyl)-N-(2-hydroxyethyl)-N-methylacrylamide hydrochloride
Amine used: 2-methylaminoethanol
Mass spectrum: MH+ 237 (100)
ag. 3-(5-Amino-2-hydroxyphenyl)-N-ethyl-N-(2-hydroxyethyl)acrylamide hydrochloride
Amine used: 2-ethylaminoethanol
Mass spectrum: MH+ 251 (80)
ah. 3-(5-Amino-2-hydroxyphenyl)-1-(2-hydroxymethylpyrrolidin-1-yl)propenone hydrochloride
Amine used: prolinol
Mass spectrum: MH+ 263 (100)
ai. 1-[3-(5-Amino-2-hydroxyphenyl)acryloyl]pyrrolidine-2-carboxamide hydrochloride
Amine used: prolinamide
Mass spectrum: MH+ 276 (100)
aj. 3-(5-Amino-2-hydroxyphenyl)-1-(3-hydroxypiperidin-1yl)propenone hydrochloride
Amine used: 3-hydroxypiperidine
Mass spectrum: MH+ 263 (100)
ak. 3-(5-Amino-2-hydroxyphenyl)-N-(2-hydroxy-1-hydroxymethylethyl)acrylamide hydrochloride
Amine used: 3-amino-1,2-propanediol
Mass spectrum: MH+ 253 (100)
al. 2-[3-(5-Amino-2-hydroxyphenyl)acryloylamino]-3-methylbutyric acid hydrochloride
Amine used: α-aminoisovaleric acid
Mass spectrum: MH+ 279 (100)
am. 3-(5-Amino-2-hydroxyphenyl)-N-(1-carbamoyl-2-hydroxyethyl)acrylamide hydrochloride
Amine used: 2-amino-3-hydroxypropionamide
Mass spectrum: MH+ 266 (100)
an. 3-(5-Amino-2-hydroxyphenyl)-N-(3-hydroxy-4-methylphenyl)acrylamide hydrochloride
Amine used: 5-amino-2-methylphenol
Mass spectrum: MH+ 285 (100)
ao. 3-(5-Amino-2-hydroxyphenyl)-N-(2-hydroxy-5-nitrophenyl)acrylamide hydrochloride
Amine used: 2-amino-4-nitrophenol
Mass spectrum: MH+ 316 (100)
Examples 2 to 39
Hair Colorants
Hair colorant solutions having the following composition were prepared:














1.25
mmol
of developer of formula (I) as per Table 1


1.25
mmol
of coupler according to Table 1


1.0
g
of potassium oleate (8% aqueous solution)


1.0
g
of ammonia (22% aqueous solution)


1.0
g
of ethanol


0.3
g
of ascorbic acid


to 100.0
g
water









Just before use, 30 g of the foregoing coloring solution was mixed with 30 g of a 6% aqueous hydrogen peroxide solution. The mixture was then applied to bleached hair. After an exposure time of 30 min at 40° C., the hair was rinsed with water, washed with a commercial shampoo and dried. The resulting color shades are presented in Table 1.









TABLE 1









Coupler













II.






1,3-Diamino-
III.




Developer
4-(2-hydroxy-
5-Amino-



Example
of formula
ethoxy)ben-
2-methyl-
IV


No.
(I)
zene sulfate
phenol
1-Naphthol














2
As per Ex. 1a
red-brown
red-orange
violet


3
As per Ex. 1b
red-brown
red-orange
violet


4
As per Ex. 1c
red-brown
red-orange
violet


5
As per Ex. 1d
red-brown
red-orange
bright violet


6
As per Ex. 1e
red-brown
red-orange
bright violet


7
As per Ex. 1f
red-brown
red-orange
bright violet


8
As per Ex. 1g
red-brown
red-orange
bright violet


9
As per Ex. 1h
red-brown
red-orange
bright violet


10
As per Ex. 1i
red-brown
red-orange
bright violet


11
As per Ex. 1j
red-brown
red-orange
bright violet


12
As per Ex. 1k
red-brown
red-orange
bright violet


13
As per Ex. 1l
red-brown
red-orange
bright violet


14
As per Ex. 1m
red-brown
red-orange
bright violet


15
As per Ex. 1n
red-brown
red-orange
bright violet


16
As per Ex. 1o
red-brown
red-orange
bright violet


17
As per Ex. 1p
red-brown
red-orange
bright violet


18
As per Ex. 1q
red-brown
red-orange
bright violet


19
As per Ex. 1r
red-brown
brown
bright violet


20
As per Ex. 1s
red-brown
red-brown
bright violet


21
As per Ex. 1t
red-brown
red-orange
bright violet


22
As per Ex. 1u
red-brown
red-orange
bright violet


23
As per Ex. 1v
red-brown
red-orange
bright violet


24
As per Ex. 1x
red-brown
bright
bright violet





red-orange


25
As per Ex. 1y
red-brown
bright
bright violet





red-orange


26
As per Ex. 1z
red-brown
bright
bright violet





red-orange


27
As per Ex. 1aa
red-brown
red
bright violet


28
As per Ex. 1ab
red-brown
bright
bright violet





red-orange


29
As per Ex. 1ac
red-brown
bright
bright violet





red-orange


30
As per Ex. 1ae
red-brown
bright
bright violet





red-orange


31
As per Ex. 1af
red-brown
bright
bright violet





red-orange


32
As per Ex. 1ag
red-brown
bright
bright violet





red-orange


33
As per Ex. 1ah
red-brown
bright
bright violet





red-orange


34
As per Ex. 1ai
red-brown
bright
bright violet





red-orange


35
As per Ex. 1aj
red-brown
bright
bright violet





red-orange


36
As per Ex. 1ak
red-brown
bright
bright violet





red-orange


37
As per Ex. 1al
red-brown
bright
bright violet





red-orange


38
As per Ex. 1m
red-brown
bright
bright violet





red-orange


39
As per Ex. 1n
red-brown
bright
bright violet





red-orange









Examples 40 to 71
Hair Colorants
Hair colorant solutions of the following composition were prepared:














X
g
of developer E1 or E2 of formula (I), as per Table 3


U
g
of developer E3 to E10 as per Table 3


Y
g
of coupler K11 to K36 as per Table 4


Z
g
of direct dye D1 to D3 as per Table 2


10.0
g
of potassium oleate (8% aqueous solution)


10.0
g
of ammonia (22% aqueous solution)


10.0
g
of ethanol


0.3
g
of ascorbic acid


to 100.0
g
water









Just before use, 30 g of the foregoing coloring solution was mixed with 30 g of a 6% aqueous solution of hydrogen peroxide. The mixture was then applied to bleached hair. After an exposure time of 30 min at 40° C., the hair was rinsed with water, washed with a commercial shampoo and dried. Table 5 shows the coloring results.
Examples 72 to 77
Hair Colorants
Dye carriers in cream form and having the following composition were prepared:














X
g
of developer E1 of formula (I) as per Table 3


U
g
of developer E3 to E10 as per Table 3


Y
g
of coupler K11 to K36 as per Table 4


Z
g
of direct dye D1 to D3 as per Table 2


15.0
g
of cetyl alcohol


0.3
g
of ascorbic acid


3.5
g
of sodium lauryl alcohol diethylene glycol




ether sulfate, 28% aqueous solution


3.0
g
of ammonia, 22% aqueous solution


0.3
g
of sodium sulfite, anhydrous


to 100
g
water









Just before use, 30 g of the foregoing coloring cream was mixed with 30 g of a 6% solution of hydrogen peroxide. The mixture was then applied to the hair. After an exposure time of 30 min, the hair was rinsed with water, washed with a commercial shampoo and dried. The coloring results are presented in Table 6 hereinbelow.







TABLE 2





Direct Dyes


















D1
2,6-diamino-3-[(pyridin-3-yl)azo]pyridine



D2
6-chloro-2-ethylamino-4-nitrophenol



D3
2-amino-6-chloro-4-nitrophenol

















TABLE 3





Developers


















E1
3-(5-amino-2-hydroxyphenyl)-N-ethyl-




acrylamide hydrochloride



E2
3-(5-amino-2-hydroxyphenyl)-N-(4-aminophenyl)-




acrylamide hydrochloride



E3
2,5-diaminophenylethanol sulfate



E4
3-methyl-4-aminophenol



E5
4-amino-2-aminomethylphenol dihydrochloride



E6
4-aminophenol



E7
N,N-bis-(2′-hydroxyethyl)-p-phenylenediamine sulfate



E8
4,5-diamino-1-(2′-hydroxyethyl)pyrazole sulfate



E9
2,5-diaminotoluene sulfate



E10
1,4-diaminobenzene

















TABLE 4





Couplers


















K11
1,3-diaminobenzene



K12
2-amino-4-(2′-hydroxyethyl)aminoanisole sulfate



K13
1,3-diamino-4-(2′-hydroxyethoxy)benzene sulfate



K14
2,4-diamino-5-fluorotoluene sulfate



K16
3,5-diamino-2,6-dimethoxypyridine dihydrochloride



K17
2,4-diamino-5-ethoxytoluene sulfate



K18
N-(3-dimethylamino)phenylurea



K19
1,3-bis-(2,4-diaminophenoxy)propane tetrahydrochloride



K21
3-aminophenol



K22
5-amino-2-methylphenol



K23
3-amino-2-chloro-6-methylphenol



K24
5-amino-4-fluoro-2-methylphenol sulfate



K25
1-naphthol



K26
1-acetoxy-2-methylnaphthalene



K31
1,3-dihydroxybenzene



K32
2-methyl-1,3-dihydroxybenzene



K33
1-chloro-2,4-dihydroxybenzene



K34
4-(2′-hydroxyethyl)amino-1,2-methylenedioxy-




benzene hydrochloride



K35
3,4-methylenedioxyphenol



K36
2-amino-5-methylphenol

















TABLE 5





Hair Colorants





















Example
40
41
42
43
44
45











Dyes
(Quantity of dyes in grams)













E1
0.096
0.24
0.30
0.04
0.01
0.70


E9




0.096
1.80


E10



0.90


K11





0.05


K12




0.01


K18





0.03


K21




0.02
0.06


K22
0.08
0.20
0.25
0.056

0.42


K24



0.05

0.11


K25




0.03


K31



0.20

0.80


K32

0.03
0.05
0.316


K35
0.018


K36

0.03
0.05
0.01


K26


D1



0.01


D3
0.04
0.06
0.025


Color
bright-
copper-
bright
purple-
silver-
dark


shade
blond to
gold
copper
brown
blond
mahogany



copper-

color



gold
















Example
46
47
48
49
50
51











Dyes
(Quantity of dyes in grams)













E1
0.01
0.60
1.00
0.20
0.80
0.60


E10
2.00


1.90


E3

0.05


E7


0.06


E8


1.00


E9




1.00
0.70


K12


1.10


K13
0.07




0.80


K16





1.00


K17


1.10


K18



1.25


K21
0.40


0.28


K22
0.08
0.40


K24

0.10


K25




0.80


K31
0.80


K32

0.03


K33




0.75


K36

0.03


D1

0.25


D3

0.15


Color
black-
orange
blue-
blue-red
pink
Bordeaux


shade
brown

violet

colors
colors














Example
52
53
54
55











Dyes
(Quantity of dyes in grams)











E1
0.01
0.01
0.05
0.60


E3
1.40
4.50


E5



0.25


E6


0.10


E8

0.80
0.50
0.01


E9
2.50


K12
0.60


K13
0.20


0.80


K14

0.25


K16
0.01


K18



1.25


K19
0.80


K21
0.30


0.28


K22

5.00


K25

0.40


K23


0.60


K31
1.10


K32



0.33


K36


0.19


D2


0.50


Shade
black
red-violet
red-orange
warm yellow
















Example
56
57
58
59
60
61











Dyes
(Quantity of dyes in grams)













E2
0.096
0.24
0.30
0.04
0.01
0.70


E10



0.90


E9




0.096
1.80


K12




0.01


K18





0.03


K21




0.02
0.06


K22
0.08
0.20
0.25
0.056

0.58


K25




0.03


K31



0.20

0.80


K32

0.03
0.05
0.316


K35
0.018


K36

0.03
0.05
0.01


K26


D1



0.01


D3
0.04
0.06
0.025


Color
bright-
copper-
bright
purple-
silver-
dark


shade
blond to
gold
copper
brown
blond
mahogany



copper-

colors



gold
















Example
62
63
64
65
66
67











Dyes
(Quantity of dyes in grams)













E2
0.01
0.60
1.00
0.20
0.80
0.60


E10
2.00


1.90


E3

0.05


E8


1.00


E9




1.00
0.70


K12


1.10


K13
0.07




0.80


K16





1.00


K17


1.10


K18



1.25


K21
0.40


0.28


K22
0.08
0.50


K25




0.80


K31
0.80


K32

0.03


K33




0.75


K36

0.03


D1

0.25


D3

0.15


Color
black-
orange
blue-
blue-red
pink
Bordeaux


shade
brown

violet

colors
colors














Example
68
69
70
71











Dyes
(Quantity of dyes in grams)











E2
0.01
0.01
0.05
0.60


E3
1.40
4.50


E5



0.25


E6


0.10


E8

0.80
0.50
0.01


E9
2.70


K12
0.60


K13
0.20


0.80


K14

0.25


K16
0.01


K18



1.25


K19
0.80


K21
0.30


0.28


K22

5.00


K25

0.40


K23


0.60


K31
1.10


K32



0.33


K34
0.20


K36


0.19


D2


0.50


Shade
black
red-violet
red-orange
warm yellow
















TABLE 6







Hair Colorants









Example














72
73
74
75
76
77








Dyes
(Quantity of dyes in grams)
















E1
0.10
0.20
0.01
2.00
0.50
0.70


E4





1.60


E8



0.25
0.80
0.20


E9
3.20
1.71
0.02


1.80


K13
0.23
0.10


1.30


K14
0.20


K16


0.015


K21
0.40
0.80


0.02


K22
0.08

0.25
1.80

4.50


K23

0.20


0.03


K31
1.05
0.135
0.02
0.25

0.80


K25





0.55


K26


0.03


K19




1.70


K36

0.27


D2

0.01


Color
dark
choco-
silver
orange
blue-
red-


shade
brown
late
blond
colors
violet
violet




brown









Unless otherwise indicated, all percentages in the present patent application are by weight.

## Claims

1. A (p-aminohydroxyphenyl)acrylamide derivative of formula (I), or a physiologically tolerated, water-soluble salt thereof: 




wherein
R1 denotes hydrogen, a halogen atom, a C1-C4-alkyl group, a C1-C4-hydroxyalkyl group or a C1-C4-alkoxy group; 
R2 and R3 independently of each other denote hydrogen or a C1-C6-alkyl group; 
R4 denotes a C1-C2-alkyl group, a methoxy group or a C2-C4-hydroxyalkyl group; 
R5 denotes a C2-C4-hydroxyalkyl group; 
R6 denotes hydrogen, a carboxy group or an aminocarbonyl group; 
R7 and R8, independently of each other, denote hydrogen, a hydroxyl group, an aminocarbonyl group, a methylthiomethyl group, a phenyl-substituted or hydroxyl-substituted phenyl group or a group of formula 




R9, R10, R11, R12 and R13, independently of each other, denote hydrogen, a halogen atom, a cyano group, a hydroxyl group, a C1-C4-alkoxy group, a C1-C4-hydroxyalkoxy group, a C1-C6-alkyl group, a C1-C4-alkyl thioether group, a mercapto group, a nitro group, an amino group, an alkylamino group, a C1-C4-hydroxyalkylamino group, a dialkylamino group, a di(C1-C4-hydroxyalkyl)amino group, a (C3-C4-dihydroxyalkyl)-amino group, a (C1-C4-hydroxyalkyl)-C1-C4-alkylamino group, a trifluoromethyl group, a —C(O)H group, a —C(O)CH3— group, a —C(O)CF3 group, an —Si(CH3)3 group, a C1-C4-hydroxyalkyl group or a C3-C4-dihydroxyalkyl group, or two adjacent R9 to R13 groups form an —O—CH2—O— bridge; 
R14 denotes a C1-C4-alkyl group, a benzyl group or a C2-C4-hydroxyalkyl group; 
R15 denotes hydrogen or a C1-C6-alkyl group; 
R16 denotes hydrogen, a hydroxyl group, a carboxy group, an aminocarbonyl group or a hydroxymethyl group; and 
R17 denotes hydrogen or a C1-C6-alkyl group.

2. A (p-aminohydroxyphenyl)acrylamide derivative selected from the group consisting of 3-(5-amino-2-hydroxyphenyl)-N-ethylacrylamide, 3-(2-amino-5-hydroxyphenyl)-N-ethylacrylamide, 3-(5-amino-2-hydroxyphenyl)-N-(4-hydroxyphenyl)acrylamide, 3-(2-amino-5-hydroxyphenyl)-N-(4-hydroxy-phenyl)-acrylamide, 3-(5-amino-2-hydroxyphenyl)-N-(4-aminophenyl)acrylamide, 3-(2-amino-5-hydroxyphenyl)-N-(4-aminophenyl)acrylamide, or a physiologically tolerated salt thereof.

3. An agent for oxidative dyeing of keratin fibers, wherein said agent comprises at least one developer and at least one coupler, said at least one developer comprising at least one (p-aminohydroxyphenyl)acrylamide derivative of formula (I), or a physiologically-tolerated, water-soluble salt thereof: 




wherein
R1 denotes hydrogen, a halogen atom, a C1-C4-alkyl group, a C1-C4-hydroxyalkyl group or a C1-C4-alkoxy group; 
R2 and R3, independently of each other, denote hydrogen or a C1-C6-alkyl group; 
R4 and R5, independently of each other, denote hydrogen, a C1-C2-alkoxy group, a C1-C6-alkyl group, an unsaturated a C3-C6-alkyl group, a C2-C4-hydroxyalkyl group, a C3-C4-dihydroxyalkyl group, a C2-C4-aminoalkyl group, a C2-C4-dimethylaminoalkyl group, a C2-C4-acetylaminoalkyl group, a C2-C4-methoxyalkyl group, a C2-C4-ethoxyalkyl group, a C1-C4-cyanoalkyl group, a C1-C4-carboxyalkyl group, a C1-C4-aminocarbonylalkyl group, a pyridylmethyl group, a furfuryl group, a thienylmethyl group, a hydrogenated furfuryl group, a substituted pyridyl group, a group of formula (II) 




a group of formula (III) 




or a group of formula (IV) 




or R4 and R5 together with N form a ring of the following formula: 




R6 denotes hydrogen, a carboxy group or an aminocarbonyl group; 
R7 and R8, independently of each other, denote hydrogen, a hydroxyl group, an aminocarbonyl group, a methylthiomethyl group, a phenyl-substituted or hydroxyl-substituted phenyl group or a group of formula 




R9, R10, R11, R12 and R13, independently of each other, denote hydrogen, a halogen atom, a cyano group, a hydroxyl group, a C1-C4-alkoxy group, a C1-C4-hydroxyalkoxy group, a C1-C6-alkyl group, a C1-C4-alkyl thioether group, a mercapto group, a nitro group, an amino group, an alkylamino group, a C1-C4-hydroxyalkylamino group, a dialkylamino group, a di(C1-C4-hydroxyalkyl)amino group, a (C3-C4-dihydroxyalkyl)-amino group, a (C1-C4-hydroxyalkyl)-C1-C4-alkylamino group, a trifluoromethyl group, a —C(O)H group, a —C(O)CH3— group, a —C(O)CF3 group, an —Si(CH3)3 group, a C1-C4-hydroxyalkyl group or a C3-C4-dihydroxyalkyl group, or two adjacent R9 to R13 groups form an —O—CH2—O— bridge; 
R14 denotes a C1-C4-alkyl group, a benzyl group or a C2-C4-hydroxyalkyl group; 
R15 denotes hydrogen or a C1-C6-alkyl group; 
R16 denotes hydrogen, a hydroxyl group, a carboxy group, an aminocarbonyl group or a hydroxymethyl group; and 
R17 denotes hydrogen or a C1-C6-alkyl group.

4. The agent as defined in claim 3, containing from 0.005 to 20 percent by weight of said at least one (p-aminohydroxyphenyl)acrylamide derivative.

5. The agent as defined in claim 3, wherein the at least one coupler is selected from the group consisting of N-(3-dimethylaminophenyl)urea, 2,6-diamino-pyridine, 2-amino-4-[(2-hydroxyethyl)amino]anisole, 2,4-diamino-1-fluoro-5-methylbenzene, 2,4-diamino-1-methoxy-5-methylbenzene, 2,4-diamino-1-ethoxy-5-methylbenzene, 2,4-diamino-1-(2-hydroxyethoxy)-5-methylbenzene, 2,4-di[(2-hydroxyethyl)amino]-1,5-dimethoxybenzene, 2,3-diamino-6-methoxy-pyridine, 3-amino-6-methoxy-2-(methylamino)pyridine, 2,6-diamino-3,5-dimethoxypyridine, 3,5-diamino-2,6-dimethoxypyridine, 1,3-diaminobenzene, 2,4-diamino-1-(2-hydroxyethoxy)benzene, 1,3-diamino-4-(2,3-dihydroxy-propoxy)benzene, 1,3-diamino-4-(3-hydroxypropoxy)benzene, 1,3-diamino-4-(2-methoxyethoxy)benzene, 2,4-diamino-1,5-di(2-hydroxyethoxy)benzene, 1-(2-aminoethoxy)-2,4-diaminobenzene, 2-amino-1-(2-hydroxyethoxy)-4-methyl-aminobenzene, 2,4-diaminophenoxyacetic acid, 3-[di(2-hydroxyethyl)amino]-aniline, 4-amino-2-di[(2-hydroxyethyl)amino]-1-ethoxybenzene, 5-methyl-2-(1-methylethyl)phenol, 3-[(2-hydroxyethyl)amino]aniline, 3-[(2-aminoethyl)amino]aniline, 1,3-di(2,4-diaminophenoxy)propane, di(2,4-diaminophenoxy)methane, 1,3-diamino-2,4-dimethoxybenzene, 2,6-bis(2-hydroxyethyl)aminotoluene, 4-hydroxyindole, 3-dimethylaminophenol, 3-diethylaminophenol, 5-amino-2-methylphenol, 5-amino-4-fluoro-2-methylphenol, 5-amino-4-methoxy-2-methylphenol, 5-amino-4-ethoxy-2-methylphenol, 3-amino-2,4-dichlorophenol, 5-amino-2,4-dichlorophenol, 3-amino-2-methylphenol, 3-amino-2-chloro-6-methylphenol, 3-aminophenol, 2-[(3-hydroxyphenyl)-amino]acetamide, 5-[(2-hydroxyethyl)amino]-4-methoxy-2-methylphenol, 5-[(2-hydroxyethyl)amino]-2-methylphenol, 3-[(2-hydroxyethyl)amino]phenol, 3-[(2-methoxyethyl)amino]-phenol, 5-amino-2-ethylphenol, 5-amino-2-methoxyphenol, 2-(4-amino-2-hydroxyphenoxy)ethanol, 5-[(3-hydroxypropyl)amino]-2-methylphenol, 3-[(2,3-dihydroxypropyl)amino]-2-methylphenol, 3-[(2-hydroxyethyl)amino]-2-methyl-phenol, 2-amino-3-hydroxypyridine, 2,6-dihydroxy-3,4-dimethylpyridine, 5-amino-4-chloro-2-methylphenol, 1-naphthol, 2-methyl-1-naphthol, 1,5-dihydroxynaphthalene, 1,7-dihydroxynaphthalene, 2,3-dihydroxynaphthalene, 2,7-dihydroxynaphthalene, 2-methyl-1-naphthol acetate, 1,3-dihydroxybenzene, 1-chloro-2,4-dihydroxybenzene, 2-chloro-1,3-dihydroxybenzene, 1,2-dichloro-3,5-dihydroxy-4-methylbenzene, 1,5-dichloro-2,4-dihydroxybenzene, 1,3-dihydroxy-2-methylbenzene, 3,4-methylenedioxyphenol, 3,4-methylenedioxyaniline, 5-[(2-hydroxyethyl)amino]-1,3-benzodioxole, 6-bromo-1-hydroxy-3,4-methylenedioxybenzene, 3,4-diaminobenzoic acid, 3,4-dihydro-6-hydroxy-1,4-(2H)benzoxazine, 6-amino-3,4-dihydro-1,4[2H]benzoxazine, 3-methyl-1-phenyl-5-pyrazolone, 5,6-dihydroxyindole, 5,6-dihydroxyindoline, 5-hydroxyindole, 6-hydroxyindole, 7-hydroxyindole and 2,3-indolinedione.

6. The agent as defined in claim 3, further comprising at least one compound selected from the group consisting of 1,4-diaminobenzene, 1,4-diamino-2-methylbenzene, 1,4-diamino-2,6-dimethylbenzene, 1,4-diamino-3,5-diethylbenzene, 1,4-diamino-2,5-dimethylbenzene, 1,4-diamino-2,3-dimethylbenzene, 2-chloro-1,4-diaminobenzene, 1,4-diamino-2-(thiophen-2-yl)benzene, 1,4-diamino-2-(thiophen-3-yl)benzene, 1,4-diamino-2-(pyridin-3-yl)benzene, 2,5-diaminobiphenyl, 1,4-diamino-2-methoxymethylbenzene, 1,4-diamino-2-aminomethylbenzene, 1,4-diamino-2-hydroxymethylbenzene, 1,4-diamino-2-(2-hydroxyethoxy)benzene, 2-[2-(acetylamino)ethoxy]-1,4-diaminobenzene, 4-phenyl-aminoaniline, 4-dimethylaminoaniline, 4-diethylaminoaniline, 4-dipropylaminoaniline, 4-[ethyl(2-hydroxyethyl)amino]-aniline, 4-[di(2-hydroxyethyl)amino]aniline, 4-[di(2-hydroxyethyl)amino]-2-methylaniline, 4-[(2-methoxyethyl)-amino]aniline, 4-[(3-hydroxy-propyl)amino]aniline, 4-[(2,3-dihydroxypropyl)-amino]aniline, 1,4-diamino-2-(1-hydroxyethyl)benzene, 1,4-diamino-2-(2-hydroxyethyl)benzene, 1,4-diamino-2-(1-methylethyl)benzene, 1,3-bis-[(4-aminophenyl)(2-hydroxyethyl)amino]-2-propanol, 1,4-bis-[1-(4-aminophenyl)amino]butane, 1,8-bis-(2,5-diaminophenoxy)-3,6-dioxaoctane, 4-aminophenol, 4-amino-3-methylphenol, 4-amino-3-(hydroxymethyl)phenol, 4-amino-3-fluorophenol, 4-methylaminophenol, 4-amino-2-(aminomethyl)phenol, 4-amino-2-(hydroxymethyl)phenol, 4-amino-2-fluorophenol, 4-amino-2-[2-hydroxyethyl)amino]methylphenol, 4-amino-2-methylphenol, 4-amino-2-(methoxymethyl)-phenol, 4-amino-2-(2-hydroxyethyl)phenol, 5-aminosalicylic acid, 2,5-diaminopyridine, 2,4,5,6-tetraaminopyrimidine, 2,5,6-triamino-4-(1H)-pyrimidone, 4,5-diamino-1-(2-hydroxyethyl)-1H-pyrazole, 4,5-diamino-1-(1-methylethyl)-1H-pyrazole, 4,5-diamino-1-[(4-methylphenyl)methyl]-1H-pyrazole, 1-[(4-chlorophenyl)methyl]-4,5-diamino-1H-pyrazole, 4,5-diamino-1-methyl-1H-pyrazole, 2-aminophenol, 2-amino-6-methylphenol, 2-amino-5-methylphenol and 1,2,4-trihydroxybenzene.

7. The agent as defined in claim 3, containing from 0.005 to 20 percent by weight of each of said at least one coupler and said at least one developer, based on a total amount of the agent.

8. The agent as defined in claim 3, further comprising at least one direct dye.

9. The agent as defined in claim 3, consisting of a hair colorant.