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                                                                    EXHIBIT 10.2



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                              AMENDED AND RESTATED
                          REGISTRATION RIGHTS AGREEMENT


                                      among


                   INTEGRA LIFESCIENCES HOLDINGS CORPORATION,


                        QUANTUM INDUSTRIAL PARTNERS LDC,


                                       and


                          SFM DOMESTIC INVESTMENTS LLC



                           ---------------------------

                              Dated: March 29, 2000

                           ---------------------------





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                                TABLE OF CONTENTS

                                                                     Page

1.    Definitions......................................................1

2.    General; Securities Subject to this Agreement....................4
      (a)   Grant of Rights............................................4
      (b)   Registrable Securities.....................................4
      (c)   Holders of Registrable Securities..........................4

3.    Demand Registration..............................................4
      (a)   Request for Demand Registration............................4
      (b)   Effective Demand Registration..............................5
      (c)   Expenses...................................................5
      (d)   Underwriting Procedures....................................5
      (e)   Selection of Underwriters..................................6

4.    Piggy-Back Registration..........................................6
      (a)   Piggy-Back Rights..........................................6
      (b)   Expenses...................................................7

5.    Holdback Agreements..............................................7
      (a)   Restrictions on Public Sale by Designated Holders..........7
      (b)   Restrictions on Public Sale by the Company.................8

6.    Registration Procedures..........................................8
      (a)   Obligations of the Company.................................8
      (b)   Obligations of Each Designated Holder of Registrable
            Securities................................................11
      (c)   Notice to Discontinue.....................................12
      (d)   Registration Expenses.....................................13

7.    Indemnification; Contribution...................................13
      (a)   Indemnification by the Company............................13
      (b)   Indemnification by Designated Holders.....................14
      (c)   Conduct of Indemnification Proceedings....................14
      (d)   Contribution..............................................15

8.    Rule 144........................................................16

9.    Miscellaneous...................................................16
      (a)   Recapitalizations, Exchanges, etc.........................16
      (b)   No Inconsistent Agreements................................16
      (c)   Remedies..................................................16
      (d)   Amendments and Waivers....................................16


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      (e)   Notices...................................................17
      (f)   Successors and Assigns; Third Party Beneficiaries.........18
      (g)   Counterparts..............................................18
      (h)   Headings..................................................19
      (i)   GOVERNING LAW.............................................19
      (j)   Severability..............................................19
      (k)   Entire Agreement..........................................19
      (l)   Further Assurances........................................19



<PAGE>


               AMENDED AND RESTATED REGISTRATION RIGHTS AGREEMENT


            AMENDED AND RESTATED REGISTRATION RIGHTS AGREEMENT, dated March 29,
2000 (this "Agreement"), among INTEGRA LIFESCIENCES HOLDINGS CORPORATION, a
Delaware corporation (the "Company"), QUANTUM INDUSTRIAL PARTNERS LDC, a Cayman
Islands limited duration company ("QIP"), and SFM DOMESTIC INVESTMENTS LLC, a
Delaware limited liability company ("SFM DI" and together with QIP, the
"Stockholders").

            WHEREAS, in connection with the Series B Convertible Preferred Stock
and Warrant Purchase Agreement, dated March 29, 1999, among the Company and the
Stockholders (the "Series B Agreement"), the Company and the Stockholders
entered into a Registration Rights Agreement, dated March 29, 1999 (the
"Original Agreement"), granting the Stockholders certain registration rights;
and

            WHEREAS, in order to induce the Stockholders to enter into the
Series C Convertible Preferred Stock and Warrant Purchase Agreement, dated
February 16, 2000 (the "Series C Agreement"), among the Company and the
Stockholders, pursuant to which the Company has agreed to issue and sell to the
Stockholders, and the Stockholders have agreed to purchase from the Company, (i)
an aggregate of 54,000 shares of Series C Convertible Preferred Stock, par value
$.01 per share, of the Company (the Series C Preferred Stock"), and (ii)
warrants (the "Warrants") to purchase, subject to the terms and conditions
thereof, an aggregate of 300,000 shares of Common Stock, the parties hereto have
agreed to amend and restate the Original Agreement as provided herein;

            NOW, THEREFORE, in consideration of the mutual covenants and
agreements set forth herein and for good and valuable consideration, the receipt
and adequacy of which is hereby acknowledged, the parties hereto agree as
follows:

            1.    Definitions.  As used in this Agreement the following terms
have the meanings indicated:

            "Act" means the Securities Act of 1933, as amended.

            "Affiliate" shall mean any Person who is an "affiliate" as defined
in Rule 12b-2 of the General Rules and Regulations under the Exchange Act, and
any Person controlling, controlled by, or under common control with any
Stockholder. For the purposes of this Agreement, "control" includes the ability
to have investment discretion through contractual means or by operation of law.

            "Agreement" has the meaning set forth in the recitals to this
Agreement.


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                                                                               5


            "Approved Underwriter" has the meaning assigned such term in Section
3(e).

            "Common Stock" means the Common Stock, par value $.01 per share, of
the Company or any other equity securities of the Company into which such
securities are converted, reclassified, reconstituted or exchanged.

            "Company" has the meaning set forth in the recitals to this
Agreement.

            "Company Underwriter" has the meaning assigned such term in Section
4(a).

            "Demand Registration" has the meaning assigned such term in Section
3(a).

            "Designated Holder" means each of the Stockholders, and any
transferee of any of them to whom Registrable Securities have been transferred
in accordance with the provisions of this Agreement, other than a transferee to
whom such securities have been transferred pursuant to a registration statement
under the Securities Act or Rule 144 or Regulation S under the Securities Act.

            "Exchange Act" means the Securities Exchange Act of 1934, as
amended, and the rules and regulations promulgated thereunder.

            "Existing Rightholders" means the stockholders of the Company, if
any, who have obtained registration rights pursuant to agreements existing on
the date hereof.

            "Initiating Holders" has the meaning assigned such term in Section
3(a).

            "Inspector" has the meaning assigned such term in Section
6(a)(viii).

            "NASD" has the meaning assigned such term in Section 6(a)(xiv).

            "Original Agreement" has the meaning assigned such term in the
recitals to this Agreement.

            "Person" means any individual, firm, corporation, partnership,
trust, incorporated or unincorporated association, joint venture, joint stock
company, limited liability company, government (or an agency or political
subdivision thereof) or other entity of any kind, and shall include any
successor (by merger or otherwise) of such entity.

            "QIP" means Quantum Industrial Partners LDC.


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                                                                               6


            "Records" has the meaning assigned such term in Section 6(a)(viii).

            "Registrable Securities" means each of the following: (a) any shares
of Common Stock owned by the Designated Holders issued or issuable upon
conversion of shares of Series B Preferred Stock or shares of Series C Preferred
Stock, or upon exercise of the Series B Warrants or the Warrants, (b) any shares
of Common Stock issued or issuable by the Company to any or all of the
Designated Holders during the time that any of such Designated Holders are
holders of shares of Common Stock, shares of Series B Preferred Stock or shares
of Series C Preferred Stock, (c) any other shares of Common Stock acquired or
owned by any of the Designated Holders and (d) any shares of Common Stock issued
or issuable with respect to shares of Common Stock, shares of Series B Preferred
Stock and shares of Series C Preferred Stock by way of stock dividend or stock
split or in connection with a combination of shares, recapitalization, merger,
consolidation or other reorganization or otherwise and shares of Common Stock
issuable upon conversion, exercise or exchange thereof.

            "Registration Expenses" has the meaning set forth in Section 6(d).

            "SEC" means the Securities and Exchange Commission or any similar
agency then having jurisdiction to enforce the Securities Act.

            "Securities Act" means the Securities Act of 1933, as amended, and
the rules and regulations promulgated thereunder.

            "Series B Agreement" has the meaning set forth in the recitals to
this Agreement.

            "Series B Preferred Stock" means the Series B Convertible Preferred
Stock, par value $.01, of the Company.

            "Series B Warrants" means the warrant, dated March 29, 1999, issued
by the Company to QIP to purchase 180,000 shares of Common Stock, together with
the warrant, dated March 29, 1999, issued by the Company to SFM DI to purchase
60,000 shares of Common Stock.

            "Series C Agreement" has the meaning assigned such term in the
recital to this Agreement.

            "Series C Preferred Stock" has the meaning assigned such term in the
recital to this Agreement.

            "SFM DI" has the meaning set forth in the recitals to this
Agreement.
            "Stockholders" means Quantum Industrial Partners LDC and SFM
Domestic Investments LLC.


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                                                                               7


            "Warrants" has the meaning set forth in the recitals to this
Agreement.

            2.    General; Securities Subject to this Agreement.

                  (a) Grant of Rights. The Company hereby grants registration
rights to the Stockholders upon the terms and conditions set forth in this
Agreement.

                  (b) Registrable Securities. For the purposes of this
Agreement, (i) Registrable Securities will cease to be Registrable Securities
when a registration statement covering such Registrable Securities has been
declared effective under the Securities Act by the SEC and such Registrable
Securities have been disposed of pursuant to such effective registration
statement and (ii) the securities of a Designated Holder shall be deemed not to
be Registrable Securities at any time when the Company is registered pursuant to
Section 12 of the Exchange Act and the entire amount of such Designated Holder's
Registrable Securities proposed to be sold in a single sale, in the opinion of
counsel satisfactory to the Company and the Designated Holder, each in their
reasonable judgment, may be distributed to the public pursuant to Rule 144 (or
any successor provision then in effect) under the Securities Act.

                  (c) Holders of Registrable Securities. A Person is deemed to
be a holder of Registrable Securities whenever such Person owns of record
Registrable Securities, or holds an option to purchase, or a security
convertible into or exercisable or exchangeable for, Registrable Securities,
whether or not such acquisition or conversion has actually been effected and
disregarding any legal restrictions upon the exercise of such rights. If the
Company receives conflicting instructions, notices or elections from two or more
Persons with respect to the same Registrable Securities, the Company may act
upon the basis of the instructions, notice or election received from the
registered owner of such Registrable Securities. Registrable Securities issuable
upon exercise of an option or upon conversion of another security shall be
deemed outstanding for the purposes of this Agreement.

            3.    Demand Registration.

                  (a) Request for Demand Registration. At any time on or after
the date hereof, the holders of more than 50% of the Registrable Securities
outstanding may make a written request for registration (such Designated Holders
making such request being deemed to be "Initiating Holders") of Registrable
Securities under the Securities Act, and under the securities or "blue sky" laws
of a reasonable number of jurisdictions designated by such holder or holders (a
"Demand Registration"); provided, however, that the Company shall not be
required to effect more than three Demand Registrations pursuant to this Section
3. If at the time of any request to register Registrable Securities pursuant to
this Section 3(a), the Company is engaged in, or has fixed plans to engage in
within ninety (90) days of the time of such request, a registered public
offering or is engaged in any other activity which, in the good faith
determination of the Board of Directors of the Company, would be required to be


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                                                                               8


disclosed under applicable law as a result of such request or would be adversely
affected by the requested registration, then the Company may at its option
direct that such request be delayed for a reasonable period not in excess of
three (3) months from the effective date of such offering or the date of
completion of such other activity, as the case may be, such right to delay a
request to be exercised by the Company not more than once in any one-year
period. In addition, the Company shall not be required to effect any
registration within three (3) months after the effective date of any other
Registration Statement of the Company. Each such request for a Demand
Registration by the Initiating Holders shall state the amount of the Registrable
Securities proposed to be sold, the intended method of disposition thereof and
the jurisdictions in which registration is desired. Upon a request for a Demand
Registration, the Company shall promptly take such steps as are necessary or
appropriate to prepare for the registration of the Registrable Securities to be
registered.

                  (b) Effective Demand Registration. The Company shall use
commercially reasonable efforts to cause any such Demand Registration to become
effective not later than forty-five (45) days after it receives a request under
Section 3(a) hereof and to remain effective for the lesser of (i) the period
during which all Registrable Securities registered in the Demand Registration
are sold and (ii) ninety (90) days; provided, however, that if the Initiating
Holders request the Company to withdraw such registration, it shall constitute a
Demand Registration unless the Initiating Holders promptly pay all of the costs
and expenses incurred by the Company in connection with such registration.

                  (c) Expenses. In any registration initiated as a Demand
Registration, the Company shall pay all Registration Expenses (other than
underwriting discounts and commissions and brokerage commissions), including the
reasonable fees and expenses of one counsel selected by the Designated Holders
holding a majority of the Registrable Securities being registered in such
registration ("Holders' Counsel") in connection therewith (not to exceed
$15,000), whether or not such Demand Registration becomes effective.

                  (d) Underwriting Procedures. If the Initiating Holders holding
a majority of the Registrable Securities held by all of the Initiating Holders
to which the requested Demand Registration relates so elect, the offering of
such Registrable Securities pursuant to such Demand Registration shall be in the
form of a firm commitment underwritten offering and the managing underwriter or
underwriters selected for such offering shall be the Approved Underwriter (as
hereinafter defined) selected in accordance with Section 3(e). In such event, if
the Approved Underwriter advises the Company in writing that in its opinion the
aggregate amount of such Registrable Securities requested to be included in such
offering is sufficiently large to have a material adverse effect on the success
of such offering, subject to the rights of the Existing Rightholders, the
Company shall include in such registration only the aggregate amount of
Registrable Securities that in the opinion of the Approved Underwriter may be
sold without any such material adverse effect and shall reduce,


<PAGE>
                                                                               9


first as to the Company and any stockholders who are not Designated Holders as a
group, if any, and then as to the Designated Holders as a group, pro rata within
each group based on the number of Registrable Securities included in the request
for Demand Registration, the amount of Registrable Securities to be included by
each Designated Holder in such registration.

                  (e) Selection of Underwriters. If any Demand Registration of
Registrable Securities is in the form of an underwritten offering, the
Initiating Holders holding a majority of the Registrable Securities held by all
such Initiating Holders shall select and obtain an investment banking firm of
national reputation to act as the managing underwriter of the offering (the
"Approved Underwriter"); provided, however, that the Approved Underwriter shall,
in any case, be acceptable to the Company in its reasonable judgment.

            4.    Piggy-Back Registration.

                  (a) Piggy-Back Rights. If the Company proposes to file a
registration statement under the Securities Act with respect to an offering by
the Company for its own account or for the account of an Initiating Holder
pursuant to Section 3 of any class of security (other than a registration
statement on Form S-4 or S-8 or any successor forms thereto), then the Company
shall give written notice of such proposed filing to each of the Designated
Holders of Registrable Securities (other than any Initiating Holders), and such
notice shall describe in detail the proposed registration and distribution and
shall offer such Designated Holders (other than any Initiating Holders) the
opportunity to register the number of Registrable Securities as each such holder
may request. The Company shall, and shall use commercially reasonable efforts
(within ten (10) days of the notice provided for in the preceding sentence) to
cause the managing underwriter or underwriters of a proposed underwritten
offering (the "Company Underwriter") to, permit the Designated Holders of
Registrable Securities who have requested in writing (within ten (10) days of
the giving of the notice of the proposed filing by the Company) to participate
in the registration for such offering to include such Registrable Securities in
such offering on the same terms and conditions as the securities of the Company
included therein. In connection with any offering under this Section 4(a)
involving an underwriting, the Company shall not be required to include any
Registrable Securities in such underwriting unless (i) the holders thereof
accept the terms of the underwriting as agreed upon between the Company and the
underwriters selected by it, (ii) if such underwriting has been initiated by the
Company or requested by another party that has contractual registration rights,
all of the shares of Common Stock held by the parties making such request or
entitled to include shares of Common Stock pursuant to the same rights as the
requesting parties have been included in such registration and (iii) all of the
shares of Common Stock held by Existing Rightholders for which such registration
has been requested by such Existing Rightholders have been included in such
registration, and then only in such quantity as will not, in the opinion of the
underwriters, jeopardize the success of the offering by the Company. If in the
opinion


<PAGE>
                                                                              10


of the Company Underwriter the registration of all, or part, of the Registrable
Securities which the Designated Holders have requested to be included would
materially and adversely affect such public offering, then the Company shall be
required to include in the underwriting only that number of Registrable
Securities, if any, which the Company Underwriter believes may be sold without
causing such adverse effect, and the amount of securities to be offered in the
underwriting shall be allocated first, to the Company based on the number of
shares it desires to sell in the underwritten offering for its own account; and
thereafter pro rata among the Initiating Holders and all other selling
stockholders, if any, based on the number of shares otherwise proposed to be
included therein by the Initiating Holders and such other selling stockholders.
If the number of Registrable Securities to be included in the underwriting in
accordance with the foregoing is less than the total number of shares which the
Designated Holders of Registrable Securities have requested to be included, then
the Designated Holders of Registrable Securities who have requested registration
shall participate in the underwriting pro rata based upon their total ownership
of the Registrable Securities. If any Designated Holder would thus be entitled
to include more shares than such holder requested to be registered, the excess
shall be allocated among other requesting Designated Holders pro rata based upon
their total ownership of Registrable Securities.

                  (b) Expenses. The Company shall bear all Registration Expenses
(other than underwriting discounts and commissions and brokerage commissions),
including the reasonable fees and expenses of the Holders' Counsel (not to
exceed $15,000), in connection with any registration pursuant to this Section 4.

            5.    Holdback Agreements.

                  (a) Restrictions on Public Sale by Designated Holders. Each
Designated Holder of Registrable Securities agrees not to effect any public sale
or distribution of any Registrable Securities being registered or of any
securities convertible into or exchangeable or exercisable for such Registrable
Securities, including a sale pursuant to Rule 144 under the Securities Act,
during the ninety (90) day period beginning on the effective date of such
registration statement (except as part of such registration), if and to the
extent requested by the Company in the case of a non-underwritten public
offering or if and to the extent requested by the Company Underwriter or the
Approved Underwriter in the case of an underwritten public offering, except to
the extent that such Designated Holder is prohibited by applicable law or
exercise of fiduciary duties from agreeing to withhold Registrable Securities
from sale or is acting in its capacity as a fiduciary or investment adviser. If
requested by the Company Underwriter, each Designated Holder will execute and
deliver a lock-up agreement in a form acceptable to such Underwriter and the
Company for purposes of its obligations under this Section 5. Without limiting
the scope of the term "fiduciary," a Designated Holder shall be deemed to be
acting as a fiduciary or an investment adviser if its actions or the Registrable
Securities proposed to be sold are subject to the Employee Retirement Income
Security Act of 1974, as amended, or the


<PAGE>
                                                                              11


Investment Company Act of 1940, as amended, or if such Registrable Securities
are held in a separate account under applicable insurance law or regulation.

                  (b) Restrictions on Public Sale by the Company. The Company
agrees not to effect any public sale or distribution of any of its securities
for its own account, or any securities convertible into or exchangeable or
exercisable for such securities (except pursuant to registrations on Form S-4 or
S-8 or any successor forms thereto), during the period beginning on the
effective date of any Demand Registration in which the Designated Holders of
Registrable Securities are participating and ending on the earlier of (i) the
date on which all shares of Common Stock registered on such registration
statement are sold and (ii) the date thirty (30) days after the effective date
of such registration statement.

            6.    Registration Procedures.

                  (a) Obligations of the Company. Whenever registration of
Registrable Securities has been requested pursuant to Section 3 or 4 of this
Agreement, the Company shall use commercially reasonable efforts to effect the
registration and sale of such Registrable Securities in accordance with the
intended method of distribution thereof as promptly as reasonably practicable,
and in connection with any such request, the Company shall, as promptly as
reasonably possible:

                        (i)   use commercially reasonable efforts to
prepare and file with the SEC a registration statement on any form for which the
Company then qualifies or which counsel for the Company shall deem appropriate
and which form shall be available for the sale of such Registrable Securities in
accordance with the intended method of distribution thereof, and use
commercially reasonable efforts to cause such registration statement to become
effective; provided, however, that (x) before filing a registration statement or
prospectus or any amendments or supplements thereto, the Company shall provide
Holders' Counsel and any other Inspector (as hereinafter defined) with an
adequate and appropriate opportunity to participate in the preparation of such
registration statement and each prospectus included therein (and each amendment
or supplement thereto) to be filed with the SEC, which documents shall be
subject to the review of Holders' Counsel, and (y) the Company shall notify the
Holders' Counsel and each seller of Registrable Securities of any stop order
issued or threatened by the SEC and take all reasonable action required to
prevent the entry of such stop order or to remove it if entered;

                        (ii)  prepare and file with the SEC such
amendments and supplements to such registration statement and the prospectus
used in connection therewith as may be necessary to keep such registration
statement effective for the lesser of (x) ninety (90) days and (y) such shorter
period which will terminate when all Registrable Securities covered by such
registration statement have been sold, and comply with the provisions of the
Securities Act with respect to the disposition of all securities covered by such
registration statement during such period in accordance with


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                                                                              12


the intended methods of disposition by the sellers thereof set forth in such
registration statement;

                        (iii) as soon as reasonably possible, furnish
to each seller of Registrable Securities, prior to filing a registration
statement, copies of such registration statement as is proposed to be filed, and
thereafter such number of copies of such registration statement, each amendment
and supplement thereto (in each case including all exhibits thereto), the
prospectus included in such registration statement (including each preliminary
prospectus) and such other documents as each such seller may reasonably request
in order to facilitate the disposition of the Registrable Securities owned by
such seller;

                        (iv)  use its best efforts to register or
qualify such Registrable Securities under such other securities or "blue sky"
laws of such jurisdictions as any seller of Registrable Securities may
reasonably request, and to continue such qualification in effect in such
jurisdiction for as long as permissible pursuant to the laws of such
jurisdiction, or for as long as any such seller requests or until all of such
Registrable Securities are sold, whichever is shortest, and do any and all other
acts and things which may be reasonably necessary or advisable to enable any
such seller to consummate the disposition in such jurisdictions of the
Registrable Securities owned by such seller; provided, however, that the Company
shall not be required to (x) qualify generally to do business in any
jurisdiction where it would not otherwise be required to qualify but for this
Section 6(a)(iv), (y) subject itself to taxation in any such jurisdiction or (z)
consent to general service of process in any such jurisdiction;

                        (v)   use its best efforts to cause the
Registrable Securities covered by such registration statement to be registered
with or approved by such other governmental agencies or authorities as may be
necessary by virtue of the business and operations of the Company to enable the
seller or sellers of Registrable Securities to consummate the disposition of
such Registrable Securities;

                        (vi) notify each seller of Registrable Securities, at
any time when a prospectus relating thereto is required to be delivered under
the Securities Act, upon discovery that, or upon the happening of any event as a
result of which, the prospectus included in such registration statement contains
an untrue statement of a material fact or omits to state any material fact
required to be stated therein or necessary to make the statements therein not
misleading in light of the circumstances under which they were made, and the
Company shall promptly prepare a supplement or amendment to such prospectus
(except that the Company may avoid supplementing or amending such prospectus for
up to 90 days when, in the good faith determination of the Board of Directors of
the Company, supplementing or amending such prospectus would require disclosure
under applicable law of any material activity in which the Company is then
engaged, the disclosure of which would adversely affect the Company) and furnish
to each seller a reasonable number of copies of a supplement to


<PAGE>
                                                                              13


or an amendment of such prospectus as may be necessary so that, after delivery
to the purchasers of such Registrable Securities, such prospectus shall not
contain an untrue statement of a material fact or omit to state any material
fact required to be stated therein or necessary to make the statements therein
not misleading in light of the circumstances under which they were made;

                        (vii) enter into and perform customary
agreements (including an underwriting agreement in customary form with the
Approved Underwriter or Company Underwriter, if any, selected as provided in
Sections 3 or 4) and take such other actions as are prudent and reasonably
required in order to expedite or facilitate the disposition of such Registrable
Securities;

                        (viii) make available for inspection by any seller of
Registrable Securities, any managing underwriter participating in any
disposition pursuant to such registration statement, Holders' Counsel and any
attorney, accountant or other agent retained by any such seller or any managing
underwriter (each, an "Inspector" and collectively, the "Inspectors"), all
financial and other records, pertinent corporate documents and properties of the
Company and its subsidiaries (collectively, the "Records") as shall be
reasonably necessary to enable them to exercise their due diligence
responsibility, and cause the Company's and its subsidiaries' officers,
directors and employees, and the independent public accountants of the Company,
to supply all information reasonably requested by any such Inspector in
connection with such registration statement. Records that the Company
determines, in good faith, to be confidential and which it notifies the
Inspectors are confidential shall not be disclosed by the Inspectors unless (x)
the disclosure of such Records is necessary to avoid or correct a misstatement
or omission in the registration statement, (y) the release of such Records is
ordered pursuant to a subpoena or other order from a court of competent
jurisdiction or is requested by any regulatory body (including the National
Association of Insurance Commissioners) or (z) the information in such Records
was known to the Inspectors on a non-confidential basis prior to its disclosure
by the Company or has been made generally available to the public. Each seller
of Registrable Securities agrees that it shall, upon learning that disclosure of
such Records is sought in a court of competent jurisdiction, give notice to the
Company and allow the Company, at the Company's expense, to undertake
appropriate action to prevent disclosure of the Records deemed confidential;

                        (ix)  if such sale is pursuant to an
underwritten offering, use its best efforts to obtain a "cold comfort" letter
from the Company's independent public accountants in customary form and covering
such matters of the type customarily covered by "cold comfort" letters as
Holders' Counsel or the managing underwriter reasonably request; provided,
however, that the Company shall not be required to obtain such a letter from its
former independent public accountants;

                        (x) use its best efforts to furnish, at the request of
any seller of Registrable Securities on the date such securities are delivered
to the


<PAGE>
                                                                              14


underwriters for sale pursuant to such registration or, if such securities are
not being sold through underwriters, on the date the registration statement with
respect to such securities becomes effective, an opinion, dated such date, of
counsel representing the Company for the purposes of such registration,
addressed to the underwriters, if any, and to the seller making such request,
covering such legal matters with respect to the registration in respect of which
such opinion is being given as such seller may reasonably request and are
customarily included in such opinions;

                        (xi)  otherwise use its best efforts to comply
with all applicable rules and regulations of the SEC, and make available to its
security holders, as soon as reasonably practicable but no later than fifteen
(15) months after the effective date of the registration statement, an earnings
statement covering a period of twelve (12) months beginning after the effective
date of the registration statement, in a manner which satisfies the provisions
of Section 11(a) of the Securities Act and Rule 158 thereunder;

                        (xii) cause all such Registrable Securities to
be listed on each securities exchange on which similar securities issued by the
Company are then listed, provided, that the applicable listing requirements are
satisfied;

                        (xiii) keep Holders' Counsel advised in writing as to
the initiation of any registration under Section 3 or 4 hereunder and provide
Holders' Counsel with copies of any SEC filings made in connection therewith;

                        (xiv) cooperate with each seller of Registrable
Securities and each underwriter participating in the disposition of such
Registrable Securities and their respective counsel in connection with any
filings required to be made with the National Association of Securities Dealers,
Inc. (the "NASD"); and

                        (xv) use commercially reasonable efforts to take all
other steps necessary to effect the registration of the Registrable Securities
contemplated hereby.

                  (b) Obligations of Each Designated Holder of Registrable
Securities. Following the filing of a registration statement registering the
Eligible Securities of any Designated Holder and during any period that the
registration statement is effective, each such Designated Holder shall:

                        (i)   not effect any stabilization transactions
or engage in any stabilization activity in connection with any securities of the
Company in contravention of Regulation M under the Securities Exchange Act of
1934, as amended (the "Exchange Act");

                        (ii)  furnish each broker or dealer through
whom such Designated Holder offers Eligible Securities such number of copies of
the prospectus as


<PAGE>
                                                                              15


the broker may require and otherwise comply with the prospectus delivery
requirements under the Securities Act;

                        (iii) report to the Company each month all sales and
other dispositions of Eligible Securities made by such Designated Holder during
said month;

                        (iv) not, and shall not permit any Affiliated Purchaser
(as that term is defined in Regulation M under the Exchange Act) to, bid for or
purchase for any account in which such Designated Holder has a beneficial
interest, or attempt to induce any other person to purchase, any securities of
the Company in contravention of Regulation M under the Exchange Act;

                        (v) not offer or agree to pay, directly or indirectly,
to anyone any compensation for soliciting another to purchase, or for purchasing
(other than for such Designated Holder's own account), any securities of the
Company on a national securities exchange in contravention of Regulation M under
the Exchange Act;

                        (vi) cooperate in all reasonable respects with the
Company as it fulfills its obligations under this Agreement;

                        (vii) furnish such information concerning such
Designated Holder and the distribution of the Eligible Securities as the Company
may from time to time request to the extent required by federal securities laws;
and

                        (viii) sell Eligible Securities only in the manner
described in the Registration Statement or as otherwise permitted by federal
securities laws.

                  (c) Notice to Discontinue. Each Designated Holder of
Registrable Securities agrees that, upon receipt of any notice from the Company
of the happening of any event of the kind described in Section 6(a)(vi), such
Designated Holder shall forthwith discontinue disposition of Registrable
Securities pursuant to the registration statement covering such Registrable
Securities until such Designated Holder's receipt of the copies of the
supplemented or amended prospectus contemplated by Section 6(a)(vi). If the
Company shall give any such notice, the Company shall extend the period during
which such registration statement shall be maintained effective pursuant to this
Agreement (including, without limitation, the period referred to in Section
6(a)(ii)) by the number of days during the period from and including the date of
the giving of such notice pursuant to Section 6(a)(vi) to and including the date
when the Designated Holder shall have received the copies of the supplemented or
amended prospectus contemplated by and meeting the requirements of Section
6(a)(vi).

                  (d) Registration Expenses. The Company shall pay all expenses
(other than as set forth in Sections 3(c) and 4(b)) arising from or incident to
the performance of, or compliance with, this Agreement, including, without
limitation,


<PAGE>
                                                                              16


(i) SEC, stock exchange and NASD registration and filing fees, (ii) all fees and
expenses incurred in complying with securities or "blue sky" laws (including
reasonable fees, charges and disbursements of Holders' Counsel in connection
with "blue sky" qualifications of the Registrable Securities), (iii) all
printing, messenger and delivery expenses, (iv) the fees, charges and
disbursements of counsel to the Company and of its independent public
accountants and any other accounting and legal fees, charges and expenses
incurred by the Company (including, without limitation, any expenses arising
from any special audits incident to or required by any registration or
qualification) and (v) any liability insurance or other premiums for insurance
obtained in connection with any Demand Registration or piggy-back registration
pursuant to the terms of this Agreement, regardless of whether such registration
statement is declared effective; provided, however, that, in connection with the
registration or qualification of the Eligible Securities under state securities
laws, nothing herein shall be deemed to require the Company to make any payments
to third parties in order to obtain "lock-up," escrow or other extraordinary
agreements. All of the expenses described in this Section 6 are referred to
herein as "Registration Expenses."

            7.    Indemnification; Contribution.

                  (a) Indemnification by the Company. The Company agrees to
indemnify and hold harmless, to the fullest extent permitted by law, each
Designated Holder, its officers, directors, trustees, partners, employees,
advisors and agents and each Person who controls (within the meaning of the
Securities Act or the Exchange Act) such Designated Holder from and against any
and all losses, claims, damages, liabilities and expenses (including reasonable
costs of investigation) caused by any untrue statement of a material fact
contained in any registration statement, prospectus or notification or offering
circular (as amended or supplemented if the Company shall have furnished any
amendments or supplements thereto) or caused by any omission or alleged omission
to state therein a material fact required to be stated therein or necessary to
make the statements therein (in the case of a prospectus, in light of the
circumstances under which they were made) not misleading, except insofar as the
same are caused by or contained in any information concerning such Designated
Holder furnished in writing to the Company by such Designated Holder expressly
for use therein or caused by such Designated Holder's failure to deliver a copy
of the prospectus or any amendments or supplements thereto in accordance with
the requirements of the Securities Act after the Company has furnished such
Designated Holder with a copy of the same. The Company shall also provide
customary indemnities to any underwriters of the Registrable Securities, their
officers, directors and employees and each Person who controls such underwriters
(within the meaning of the Securities Act and the Exchange Act) to the same
extent as provided above with respect to the indemnification of the Designated
Holders of Registrable Securities.

                  (b) Indemnification by Designated Holders. In connection with
any registration statement in which a Designated Holder is participating
pursuant to Section 3 or 4 hereof, each such Designated Holder shall furnish to
the Company in


<PAGE>
                                                                              17


writing such information with respect to such Designated Holder as the Company
may reasonably request or as may be required by law for use in connection with
any such registration statement or prospectus and each Designated Holder agrees
to indemnify and hold harmless, to the fullest extent permitted by law, the
Company, any underwriter retained by the Company and their respective directors,
officers, employees and each Person who controls the Company or such underwriter
(within the meaning of the Securities Act and the Exchange Act) to the same
extent as the foregoing indemnity from the Company to the Designated Holders,
but only with respect to any such information with respect to such Designated
Holder furnished in writing to the Company by such Designated Holder expressly
for use therein, or with respect to such Designated Holder's failure to deliver
a copy of the prospectus or any amendments or supplements thereto in accordance
with the requirements of the Securities Act after the Company has furnished such
Designated Holder with a copy of the same; provided, however, that the total
amount to be indemnified by such Designated Holder pursuant to this Section 7(b)
shall be limited to the net proceeds received by such Designated Holder in the
offering to which the registration statement or prospectus relates.

                  (c) Conduct of Indemnification Proceedings. Any Person
entitled to indemnification hereunder (the "Indemnified Party") agrees to give
prompt written notice to the indemnifying party (the "Indemnifying Party") after
the receipt by the Indemnified Party of any written notice of the commencement
of any action, suit, proceeding or investigation or threat thereof made in
writing for which the Indemnified Party intends to claim indemnification or
contribution pursuant to this Agreement; provided, however, that the failure so
to notify the Indemnifying Party shall not relieve the Indemnifying Party of any
liability that it may have to the Indemnified Party hereunder except to the
extent that the delay or failure to give such notice materially prejudices the
ability of the Indemnifying Party to defend such action. If notice of
commencement of any such action is given to the Indemnifying Party as above
provided, the Indemnifying Party shall be entitled to participate in and, to the
extent it may wish, jointly with any other Indemnifying Party similarly
notified, to assume the defense of such action at its own expense, with counsel
chosen by it and satisfactory to such Indemnified Party. The Indemnified Party
shall have the right to employ separate counsel in any such action and
participate in the defense thereof, but the fees and expenses of such counsel
shall be paid by the Indemnified Party unless (i) the Indemnifying Party agrees
to pay the same, (ii) the Indemnifying Party fails to assume the defense of such
action with counsel satisfactory to the Indemnified Party in its reasonable
judgment or (iii) the named parties to any such action (including any impleaded
parties) have been advised by such counsel that representation of such
Indemnified Party and the Indemnifying Party by the same counsel would be
inappropriate under applicable standards of professional conduct, in which case
the Indemnifying Party shall not have the right to assume the defense of such
action on behalf of such Indemnified Party. No Indemnifying Party shall be
liable for any settlement entered into without its written consent, which
consent shall not be unreasonably withheld.


<PAGE>
                                                                              18


                  (d) Contribution. If the indemnification provided for in this
Section 7 from the Indemnifying Party is unavailable to an Indemnified Party
hereunder in respect of any losses, claims, damages, liabilities or expenses
referred to therein, then the Indemnifying Party, in lieu of indemnifying such
Indemnified Party, shall contribute to the amount paid or payable by such
Indemnified Party as a result of such losses, claims, damages, liabilities or
expenses in such proportion as is appropriate to reflect the relative fault of
the Indemnifying Party and Indemnified Party in connection with the actions
which resulted in such losses, claims, damages, liabilities or expenses, as well
as any other relevant equitable considerations. The relative faults of such
Indemnifying Party and Indemnified Party shall be determined by reference to,
among other things, whether any action in question, including any untrue or
alleged untrue statement of a material fact or omission or alleged omission to
state a material fact, has been made by, or relates to information supplied by,
such Indemnifying Party or Indemnified Party, and the parties' relative intent,
knowledge, access to information and opportunity to correct or prevent such
action. The amount paid or payable by a party as a result of the losses, claims,
damages, liabilities and expenses referred to above shall be deemed to include,
subject to the limitations set forth in Sections 7(a), 7(b) and 7(c), any
reasonable legal or other fees, charges or expenses reasonably incurred by such
party in connection with any investigation or proceeding; provided that the
total amount to be indemnified by such Designated Holder shall be limited to the
net proceeds received by such Designated Holder in the offering.

            The parties hereto agree that it would not be just and equitable if
contribution pursuant to this Section 7(d) were determined by pro rata
allocation or by any other method of allocation which does not take account of
the equitable considerations referred to in the immediately preceding paragraph.
No person guilty of fraudulent misrepresentation (within the meaning of Section
11(f) of the Securities Act) shall be entitled to contribution from any person.

            8.    Rule 144.

            The Company covenants that it shall file any reports required to be
filed by it under the Exchange Act; and that it shall take such further action
as each Designated Holder of Registrable Securities may reasonably request
(including providing any information necessary to comply with Rules 144 and 144A
under the Securities Act), all to the extent required from time to time to
enable such Designated Holder to sell Registrable Securities without
registration under the Securities Act within the limitation of the exemptions
provided by (a) Rule 144 under the Securities Act, as such rules may be amended
from time to time, or (b) any similar rules or regulations hereafter adopted by
the SEC. The Company shall, upon the request of any Designated Holder of
Registrable Securities, deliver to such Designated Holder a written statement as
to whether it has complied with such requirements.

            9.    Miscellaneous.


<PAGE>
                                                                              19


                  (a) Recapitalizations, Exchanges, etc. The provisions of this
Agreement shall apply, to the full extent set forth herein, with respect to (i)
the shares of Common Stock and (ii) to any and all equity securities of the
Company or any successor or assign of the Company (whether by merger,
consolidation, sale of assets or otherwise) which may be issued in respect of,
in conversion of, in exchange for or in substitution of, the shares of Common
Stock and shall be appropriately adjusted for any stock dividends, splits,
reverse splits, combinations, recapitalizations and the like occurring after the
date hereof.

                  (b) No Inconsistent Agreements. The Company shall not enter
into any agreement with respect to its securities that is inconsistent with the
rights granted to the Designated Holders in this Agreement or grant any
additional registration rights to any Person or with respect to any securities
which are not Registrable Securities which are prior in right to or inconsistent
with the rights granted in this Agreement.

                  (c) Remedies. The Designated Holders, in addition to being
entitled to exercise all rights granted by law, including recovery of damages,
shall be entitled to specific performance of their rights under this Agreement.
The Company agrees that monetary damages would not be adequate compensation for
any loss incurred by reason of a breach by it of the provisions of this
Agreement and hereby agrees to waive in any action for specific performance the
defense that a remedy at law would be adequate.

                  (d) Amendments and Waivers. Except as otherwise provided
herein, the provisions of this Agreement may not be amended, modified or
supplemented, and waivers or consents to departures from the provisions hereof
may not be given unless consented to in writing by all of the parties hereto.

                  (e) Notices. All notices, demands and other communications
provided for or permitted hereunder shall be made in writing and shall be made
by registered or certified first-class mail, return receipt requested,
telecopier, overnight courier service or personal delivery:

                        (i)   if to QIP:

                              Quantum Industrial Partners LDC
                              Kaya Flamboyan 9,
                              Villemstad
                              Curacao
                              Netherlands-Antilles


<PAGE>
                                                                              20


                              with a copy to:

                              Soros Fund Management LLC
                              888 Seventh Avenue
                              New York, NY 10016
                              Telecopy:  (212) 664-0544
                              Attn: Michael Neus, Esq.

                              and a copy to:

                              Paul, Weiss, Rifkind, Wharton & Garrison
                              1285 Avenue of the Americas
                              New York, New York 10019-6064
                              Telecopy: (212) 757-3990
                              Attention: Richard S. Borisoff, Esq.

                        (ii)  If to SFM DI:

                              Soros Fund Management LLC
                              888 Seventh Avenue
                              New York, NY 10016
                              Telecopy:  (212) 664-0544
                              Attn: Michael Neus, Esq.

                              with a copy to:

                              Paul, Weiss, Rifkind, Wharton & Garrison
                              1285 Avenue of the Americas
                              New York, New York 10019-6064
                              Telecopy: (212) 757-3990
                              Attention: Richard S. Borisoff, Esq.

                        (iii) if to the Company:

                              Integra LifeSciences Holdings Corporation
                              105 Morgan Lane
                              Plainsboro, NJ 08536
                              Telecopy: (609) 799-3297
                              Attention: Stuart M. Essig,
                                         President and CEO

                              with a copy to:

                              Drinker Biddle & Shanley LLP
                              105 College Road East


<PAGE>
                                                                              21


                              Princeton, NJ 08542-0627
                              Telecopy: (609) 799-7000
                              Attention: John E. Stoddard III, Esq.

                        (iv)  if to any other Designated Holder, at its
                              address as it appears on the transfer
                              books of the Company

            All such notices and communications shall be deemed to have been
duly given when delivered by hand, if personally delivered; when delivered by
courier, if delivered by commercial courier service; five (5) Business Days
after being deposited in the mail, postage prepaid, if mailed; and when receipt
is acknowledged, if telecopied.

                  (f) Successors and Assigns; Third Party Beneficiaries. This
Agreement shall inure to the benefit of and be binding upon the successors and
assigns of each of the parties hereto. The registration rights and the other
rights of the Designated Holders contained in this Agreement shall be, with
respect to any Registrable Security, (i) automatically transferred from QIP or
SFM DI, as the case may be, to any Affiliate thereof, and (ii) in all other
cases, transferred by the Designated Holders only with the consent of the
Company. All of the obligations of the Company hereunder shall survive any such
transfer. No Person other than the parties hereto and their successors and
permitted assigns is intended to be a beneficiary of any of the rights granted
hereunder.

                  (g) Counterparts. This Agreement may be executed in any number
of counterparts and by the parties hereto in separate counterparts, each of
which when so executed shall be deemed to be an original and all of which taken
together shall constitute one and the same agreement.

                  (h) Headings. The headings in this Agreement are for
convenience of reference only and shall not limit or otherwise affect the
meaning hereof.

                  (i) GOVERNING LAW. THIS AGREEMENT SHALL BE GOVERNED BY AND
CONSTRUED IN ACCORDANCE WITH THE LAWS OF THE STATE OF NEW JERSEY, WITHOUT REGARD
TO THE PRINCIPLES OF CONFLICTS OF LAW THEREOF.

                  (j) Severability. If any one or more of the provisions
contained herein, or the application thereof in any circumstances, is held
invalid, illegal or unenforceable in any respect for any reason, the validity,
legality and enforceability of any such provision in every other respect and of
the remaining provisions hereof shall not be in any way impaired, it being
intended that all of the rights and privileges of the Designated Holders shall
be enforceable to the fullest extent permitted by law.


<PAGE>
                                                                              22


                  (k) Entire Agreement. This Agreement is intended by the
parties as a final expression of their agreement and intended to be a complete
and exclusive statement of the agreement and understanding of the parties hereto
in respect of the subject matter contained herein. There are no restrictions,
promises, warranties or undertakings, other than those set forth or referred to
herein and in the Series B Agreement and the Series C Agreement. This Agreement
supersedes all prior agreements and understandings between the parties with
respect to such subject matter, including the Original Agreement.

                  (l) Further Assurances. Each of the parties shall execute such
documents and perform such further acts as may be reasonably required or
desirable to carry out or to perform the provisions of this Agreement.


<PAGE>


                                                                           Page

            IN WITNESS WHEREOF, the undersigned have executed, or have caused to
be executed, this Agreement on the date first written above.

                              INTEGRA LIFESCIENCES HOLDINGS
                         CORPORATION

                              By: /s/ Stuart M. Essig
                                 -----------------------------------------
                                  Name:   Stuart M. Essig
                                  Title:  President and Chief
                                          Executive Officer


                              QUANTUM INDUSTRIAL PARTNERS LDC



                              By: /s/ Michael C. Neus
                                 -----------------------------------------
                                  Name:   Michael C. Neus
                                  Title:  Attorney-in-Fact


                              SFM DOMESTIC INVESTMENTS LLC



                              By: /s/ Michael C. Neus
                                 -----------------------------------------
                                  Name:   Michael C. Neus
                                  Title:  Attorney-in-Fact