# Patent

## Title
Scintillator crystals, method for making same, user thereof

## Abstract

The invention concerns an inorganic scintillator material of general composition M1-xCexBr3, wherein: M is selected among lanthanides or lanthanide mixtures of the group consisting of La, Gd, Y in particular among lanthanides or lanthanide mixtures of the group consisting of La, Gd; and x is the molar rate of substitution of M with cerium, x being not less that 0.01 mol % and strictly less than 100 mol %. The invention also concerns a method of growing such a monocrystalline scintillator material, and the use of same as component of a scintillating detector for industrial and medical purpose or in the oil industry.

## Background
The present invention relates to scintillator crystals, to a manufacturing method allowing them to be obtained and to the use of said crystals, especially in gamma-ray and/or X-ray detectors.
Scintillator crystals are widely used in detectors for gamma-rays, X-rays, cosmic rays and particles whose energy is of the order of 1 keV and also greater than this value.
A scintillator crystal is a crystal which is transparent in the scintillation wavelength range, which responds to incident radiation by emitting a light pulse.
From such crystals, generally single crystals, it is possible to manufacture detectors in which the light emitted by the crystal that the detector comprises is coupled to a light-detection means and produces an electrical signal proportional to the number of light pulses received and to their intensity. Such detectors are used especially in industry for thickness or weight measurements and in the fields of nuclear medicine, physics, chemistry and oil exploration.
A family of known scintillator crystals widely used is of the thallium-doped sodium iodide Tl:NaI type. This scintillating material, discovered in 1948 by Robert Hofstadter and which forms the basis of modern scintillators, still remains the predominant material in this field in spite of almost 50 years of research on other materials. However, these crystals have a scintillation decay which is not very fast.
A material which is also used is CsI which, depending on the applications, may be used pure, or doped either with thallium (Tl) or with sodium (Na).
One family of scintillator crystals which has undergone considerable development is of the bismuth germanate (BGO) type. The crystals of the BGO family have high decay time constants; which limit the use of these crystals to low count rates.
A more recent family of scintillator crystals was developed in the 1990s and is of the cerium-activated lutetium oxyorthosilicate Ce:LSO type. However these crystals are very heterogeneous and have very high melting points (about 2200° C.)
The development of new scintillating materials for improved performance is the subject of many studies.
One of the parameters that it is desired to improve is the energy resolution.
This is because in the majority of nuclear detector applications, good energy resolution is desired. The energy resolution of a nuclear radiation detector actually determines its ability to separate radiation energies which are very close. It is usually determined for a given detector at a given energy, such as the width at mid-height of the peak in question on an energy spectrum obtained from this detector, in relation to the energy at the centroid of the peak (see in particular: G. F. Knoll, “Radiation Detection and Measurement”, John Wiley and Sons, Inc., 2nd edition, p. 114). In the rest of the text, and for all measurements carried out, the resolution is determined at 662 keV, the energy of the main gamma emission of 137Cs.
The smaller the energy resolution, the better the quality of the detector. It is considered that energy resolutions of about 7% enable good results to be obtained. Nevertheless, lower values of resolution are of great benefit.
For example, in the case of a detector used to analyze various radioactive isotopes, improved energy resolution enables improved discrimination of these isotopes.
An increase in the energy resolution is particularly advantageous for a medical imaging device, for example of the Anger gamma-camera or positron emission tomography (PET) type, since it enables the contrast and the quality of the images to be considerably improved, thus allowing more accurate and earlier detection of tumors.
Another very important parameter is the scintillation decay time constant; this parameter is usually measured by the “Start Stop” or “Multi-hit” method”, (described by W. W. Moses (Nucl. Instr and Meth. A336 (1993)253).
The smallest possible decay time constant is desired, so as to be able to increase the operating frequency of the detectors. In the field of nuclear medical imaging, this makes it possible, for example, to considerably reduce the length of examinations. A decay time constant which is not very high also enables the temporal resolution of devices detecting events with temporal coincidence to be improved. This is the case for positron emission tomographs (PET), where the reduction in the scintillator decay time constant enables the images to be significantly improved by rejecting noncoincident events with more accuracy.
In general, the spectrum of scintillation decay as a function of time may be broken down into a sum of exponentials, each characterized by a decay time constant.
The quality of a scintillator is essentially determined by the properties of the contribution from the fastest emission component.
The standard scintillating materials do not allow both good energy resolutions and fast decay time constants to be obtained.
This is because materials such as Tl:NaI have good energy resolution under gamma excitation, of about 7%, but a high decay time constant of about 230 ns. Similarly, Tl:CsI and Na:CsI have high decay time constants, especially greater than 500 ns.
Decay time constants which are not very high can be obtained with Ce:LSO, especially of about 40 ns, but the energy resolution under gamma excitation at 662 keV of this material is generally greater than 10%.
Recently, scintillating materials have been disclosed by O. Guillot-Noël et al. (“Optical and scintillation properties of cerium doped LaCl3, LuBr3 and LuCl3” in Journal of Luminescence 85 (1999) 21–35). This article describes the scintillation properties of cerium-doped compounds such as LaCl3 doped with 0.57 mol % Ce; LuBr3 doped with 0.021 mol %, 0.46 mol % and 0.76 mol % Ce; LuCl3 doped with 0.45 mol % Ce. These scintillating materials have quite useful energy resolutions, of the order of 7%, and decay time constants of the fast scintillation component which are fairly low, especially between 25 and 50 ns. However, the intensity of the fast component of these materials is low, especially of the order of 1000 to 2000 photons per MeV, which means that they cannot be used as a component of a high-performance detector.


The object of the present application relates to a material capable of having a low decay time constant, especially at least equivalent to that of Ce:LSO, and where the intensity of the fast scintillation component is suitable for producing a high-performance detector, in particular is greater than 4000 ph/MeV (photons per MeV), or even greater than 8000 ph/MeV (photons per MeV) and, in a preferred manner, a good energy resolution, especially at least as good as that of Tl:NaI.
According to the invention, this aim is achieved by an inorganic scintillating material of general composition M1−xCexBr3,

    
    
        where M is chosen from the lanthanides or mixtures of lanthanides of the group: La, Gd, Y, especially chosen from the lanthanides or the mixtures of lanthanides of the group: La, Gd,
        and where x is the molar level of substitution of M by cerium, subsequently called “cerium content”, where x is greater than or equal to 0.01 mol % and strictly less than 100 mol %.
    
    


The term “lanthanide” refers to the transition elements of atomic numbers 57 to 71, and to yttrium (Y), as is standard in the technical field of the invention.
An inorganic scintillating material according to the invention substantially consists of M1−xCexBr3 and may also comprise impurities usual in the technical field of the invention. In general, the usual impurities are impurities coming from the raw materials whose content is in particular less than 0.1%, or even less than 0.01%, and/or the unwanted phases whose volume percentage is especially less than 1%.
In fact, the inventors have known how to show that the M1−xCexBr3 compounds defined above, comprising cerium, have remarkable properties. The scintillation emission of these materials has an intense fast component (of at least 10000 ph/MeV) and a low decay time constant, of the order of 20 to 40 ns.
A preferred material according to the invention has the formula La1−xCexBr3; in fact this material has simultaneously an excellent energy resolution at 662 keV, in particular less that 5%, and even than 4%.
According to one embodiment, the scintillating material according to the invention has an energy resolution of less than 5% at 662 keV.
According to another embodiment, the scintillating material according to the invention has a fast decay time constant of less than 40 ns, or even of less than 30 ns.
According to a preferred embodiment, the scintillating material according to the invention has both an energy resolution less than 5% at 662 keV and a fast decay time constant of less than 40 ns, or even less than 30 ns.
In a preferred manner, the cerium content x is at least 1 mol % and is in particular between 1 and 90 mol %, and even in particular greater than or equal to 2 mol %, or even greater than or equal to 4 mol % and/or preferably less than or equal to 50 mol %, or even less than or equal to 30 mol %.
According to another embodiment, the cerium content x is between 0.01 mol % and 1 mol %, in particular at least equal to 0.1 mol %, even at least equal to 0.2 mol %. In a preferred manner, the cerium content is substantially equal to 0.5 mol %.
According to one embodiment, the scintillating material according to the invention is a single crystal making it possible to obtain components of high transparency, the dimensions of which are enough to efficiently stop and detect the radiation to be detected, including at high energy. The volume of these single crystals is in particular of the order of 10 mm3, or even greater than 1 cm3 and even greater than 10 cm3. 
According to another embodiment, the scintillating material according to the invention is a powder or polycrystal, for example in the form of powders mixed with a binder or else in the form of a sol-gel.
The invention also relates to a method for obtaining the scintillating material M1−xCexBr3, defined above, in the form of a single crystal by the Bridgman growth method, for example in evacuated sealed quartz ampoules, in particular from a mixture of commercial MBr3 and CeBr3 powders.
The invention also relates to the use of the scintillating material above as a component of a detector for detecting radiation in particular by gamma rays and/or X-rays.
Such a detector especially comprises a photodetector optically coupled to the scintillator in order to produce an electrical signal in response to the emission of a light pulse produced by the scintillator.
The photodetector of the detector may in particular be a photomultiplier, or else a photodiode, or else a CCD sensor.
The preferred use of this type of detector relates to the measurement of gamma or X-ray radiation; such a system is also capable of detecting alpha and beta radiation and electrons. The invention also relates to the use of the above detector in nuclear medicine apparatuses, especially gamma cameras of the Anger type and positron emission tomography scanners (see for example C. W. E. Van Eijk, “Inorganic Scintillator for Medical Imaging”, International Seminar New types of Detectors, 15–19 May 1995—Archamp, France. Published in “Physica Medica”, Vol. XII, supplement 1, June 96).
According to another variant, the invention relates to the use of the above detector in detection apparatuses for oil drilling, (see for example “Applications of scintillation counting and analysis”, in “Photomultiplier tube, principle and application”, chapter 7, Philips).
Other details and characteristics will emerge from the description below of preferred nonlimiting embodiments and of data obtained on samples constituting single crystals according to the invention.
Table 1 shows the characteristic scintillation results for examples according to the invention (examples 1 to 5) and for comparative examples (examples A to G).
x is the cerium content, expressed in mol %, substituted into the atom M.
The measurements are carried out under γ-ray excitation at 662 keV. The measurement conditions are specified in the publication by O. Guillot-Noël, cited above.
The emission intensity is expressed in photons per MeV.
The emission intensity is recorded as a function of the integration time up to 0.5; 3 and 10 microseconds.
The fast scintillation component is characterized by its decay time constant, τ, in nanoseconds, and by its scintillation intensity (in photons/MeV), which represents the contribution of this component to the total number of photons emitted by the scintillator.
The samples used in the measurements of examples are small single crystals of about 10 mm3.
From table 1, it is noticed that the compounds according to the invention of the M1−xCexBr3 type comprising cerium (ex1 to ex5) all have very advantageous decay time constants of fast fluorescence component, between 20 and 40 ns and the scintillation intensity of this fast component is remarkable and is very much greater than 10000 ph/MeV: in fact it reaches about 40000 ph/MeV.
In addition, the resolution, R%, of the examples according to the invention (ex1 to ex4) where M=La, is excellent and has an unexpected nature, with values between 3 and 4%, which is a considerable improvement with respect to Tl:NaI.
This is because the known lanthanide bromide compounds (examples A, B and C) do not have as remarkable a set of scintillation characteristics. For example, the cerium-doped lutetium bromides (examples B and C) have a good resolution, R%, but the intensity of the fast component is low, very substantially less that 4000 ph/MeV. As for the known lanthanide fluorides (examples D, E, F, G), they have a very low emission intensity.
In a particularly surprising manner, the inventors noticed a considerable increase in the intensity of the fast emission component for the La and Gd bromides containing cerium.
The scintillating materials according to the invention, in particular the materials of general composition La1−xCexBr3 have a performance which is particularly suitable for increasing the performance of detectors, both in terms of energy resolution, temporal resolution and count rate.












TABLE 1









x:
Emission Intensity

Fast Component













mol %
(photons/MeV)
Resolution:

Intensity















Example
Matrix
Ce3+
0.5 μs
3 μs
10 μs
(R %)
τ (ns)
(ph/MeV)


















ex1
LaBr3
0.5
63000
63000
63000
3
35
56700


ex2
LaBr3
2
48000
48000
48000
4
23
43700


ex3
LaBr3
4
48000
48000
48000
3.7
21
44200


ex4
LaBr3
10
45000
45000
45000
3.9
24
41400


ex5
GdBr3
2
28000
38000
44000
>20
20
11400


A
LaBr3
0
13000
17000
17000
15
365
11200


B
LuBr3
0.46
9000
14000
18000
7.8
32
1800


C
LuBr3
0.76
10000
17000
24000
6.5
32
2400


D
LaF3
1
≈440
≈440
440
>20
3
>100


E
LaF3
10
≈2200
≈2200
2200
>20
3
>300


F
LaF3
50
≈1900
≈1900
1900
>20
3
>200


G
CeF3
100
≈4400
≈4400
4400
>20
3
>200

## Claims

1. An inorganic scintillating material comprising a compound of the formula M1−xCexBr3,
where M is selected from the group consisting of La, Gd, Y, and mixtures thereof
and where x is the molar level of substitution of M by cerium, where x is greater than 1 mol % and less than 100 mol %.

2. The scintillating material as claimed in claim 1, wherein M is lanthanum (La).

3. The scintillating material as claimed in claim 2, wherein x is greater than 2 mol %.

4. The scintillating material as claimed in claim 3, wherein x is less than 90 mol %.

5. The scintillating material as claimed in claim 3, wherein x is less than 50 mol %.

6. The scintillating material as claimed in claim 3, wherein x is less than 30 mol %.

7. The scintillating material as claimed in claim 2, wherein x is greater than 4 mol %.

8. The scintillating material as claimed in claim 7, wherein x is less than 90 mol %.

9. The scintillating material as claimed in claim 7, wherein x is less than 50 mol %.

10. The scintillating material as claimed in claim 7, wherein x is less than 30 mol %.

11. The scintillating material as claimed in claim 2, wherein said inorganic scintillating material consists of La1−xCexBr3.

12. The scintillating material as claimed in claim 1, wherein 2 mol %≦x≦30 mol %.

13. The scintillating material as claimed in claim 1, wherein the scintillating material is a single crystal having a volume greater than 10 mm3.

14. A method of growing the single crystal scintillating material as claimed in claim 13, wherein the single crystal is obtained by the Bridgman growth method in evacuated sealed quartz ampoules from a mixture of MBr3 and CeBr3 powders.

15. The scintillating material as claimed in claim 1, wherein the scintillating material is a powder or a polycrystal.

16. A scintillation detector comprising the scintillating material as claimed in claim 1.

17. A positron emission tomography scanner or a gamma camera of the Anger type comprising the scintillating material as claimed in claim 1.

18. The inorganic scintillating material as claimed in claim 1, wherein M is selected from the group consisting of La, Gd, and mixtures thereof.

19. The scintillating material as claimed in claim 1, wherein x is less than or equal to 90 mol %.

20. The scintillating material as claimed in claim 1, wherein x is less than or equal to 50 mol %.

21. The scintillating material as claimed in claim 1, wherein x is less than or equal to 30 mol %.

22. The scintillating material as claimed in claim 1, wherein the scintillating material is a single crystal having a volume greater than 1 cm3.

23. The scintillating material as claimed in claim 1, wherein said inorganic scintillating material consists of M1−xCexBr3.

24. The inorganic scintillating material of claim 1, wherein a scintillation emission of said inorganic scintillating material has a fast scintillation component having an emission intensity of at least 10000 photons per MeV.

25. The inorganic scintillating material of claim 24, wherein said fast scintillation component has a decay time constant of at most 30 ns.

26. The inorganic scintillating material of claim 25, wherein the inorganic scintillating material has an energy resolution of at most 4% at 662 keV.

27. The inorganic scintillating material of claim 24, wherein the inorganic scintillating material has an energy resolution of at most 4% at 662 keV.

28. The inorganic scintillating material of claim 1, wherein a scintillation emission of said inorganic scintillating material has a fast scintillation component having an emission intensity of at least 40000 photons per MeV.

29. The inorganic scintillating material of claim 28, wherein said fast scintillation component has a decay time constant of at most 30 ns.

30. The inorganic scintillating material of claim 29, wherein the inorganic scintillating material has an energy resolution of at most 4% at 662 keV.

31. The inorganic scintillating material of claim 28, wherein the inorganic scintillating material has an energy resolution of at most 4% at 662 keV.

32. The inorganic scintillating material of claim 1, wherein a scintillation emission of said inorganic scintillating material has a fast scintillation component having a decay time constant of at most 30 ns.

33. The inorganic scintillating material of claim 32, wherein the inorganic scintillating material has an energy resolution of at most 4% at 662 keV.

34. The inorganic scintillating material of claim 1, wherein the inorganic scintillating material has an energy resolution of at most 4% at 662 keV.

35. An inorganic scintillating material consisting essentially of a compound of the formula M1−xCexBr3,
where M is selected from the group consisting of La, Gd, Y, and mixtures thereof and where x is the molar level of substitution of M by cerium, where x is greater than 1 mol % and less than 100 mol %.

36. The scintillating material as claimed in claim 35, wherein M is lanthanum (La).

37. The scintillating material as claimed in claim 35, wherein 2 mol %≦x≦30 mol %.

38. The scintillating material as claimed in claim 35, wherein the scintillating material is a single crystal greater than 10 mm3.

39. A method of growing the single crystal scintillating material as claimed in claim 38, wherein the single crystal is obtained by the Bridgman growth method in evacuated sealed quartz ampoules from a mixture of MBr3 and CeBr3 powders.

40. The scintillating material as claimed in claim 35, wherein the scintillating material is a powder or a polycrystal.

41. A scintillation detector comprising the scintillating material as claimed in claim 35.

42. A positron emission tomography scanner or a gamma camera of the Anger type comprising the scintillating material as claimed in claim 35.

43. The inorganic scintillating material as claimed in claim 35, wherein M is selected from the group consisting of La, Gd, and mixtures thereof.

44. The scintillating material as claimed in claim 35, wherein x is less than or equal to 90 mol %.

45. The scintillating material as claimed in claim 35, wherein x is less than or equal to 50 mol %.

46. The scintillating material as claimed in claim 35, wherein x is less than or equal to 30 mol %.

47. The scintillating material as claimed in claim 35, wherein the scintillating material is a single crystal having a volume greater than 1 cm3.