|   | 1. | Paragraph      4.A(1) shall be amended to read: "University shall be responsible for the      filing, preparation, registration, prosecution and maintenance of the      Licensed Patents; provided, however, University and Licensee shall      mutually agree to the selection of patent counsel for such filing,      prosecution and maintenance of all patent applications and patents within      the Licensed Patents." |
|--------|----|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | 2. | Paragraph      11.E shall be amended to read: |
|--------|----|-----------------------------------------------|

| If      to University: | UCTech                                              |
|------------------------|-----------------------------------------------------|
|                   | Office      of Technology and Intellectual Property |
|                   | The      University of Chicago                      |
|                   | 5555      South Woodlawn Avenue                     |
|                   | Suite      300                                      |
|                   | Chicago,      Illinois 60637                        |
|                   | Facsimile      Number: 773-702-0741                 |
|                   |                                                |
|                   | Attention:      Director of TechnologyTransfer      |

| If      to Licensee: | GenVec,      Inc.                   |
|----------------------|-------------------------------------|
|                 | 65      West Watkins Mill Road      |
|                 | Gaithersburg,      MD 20878         |
|                 | Facsimile      Number: 240-632-0735 |
|                 |                                |
|                 | Attention:      President           |

----

|   | With      a copy to: Vice President, CorporateDevelopment |
|--------|-----------------------------------------------------------|

|   | 3. | Schedule      A shall be amended to include: |
|--------|----|----------------------------------------------|

| Title:                     | Transcriptional      Targeting of an Adenoviral Delivered Tumor Necrosis Factor Alpha by      Temozolamide in Experimental Glioblastoma |
|----------------------------|-----------------------------------------------------------------------------------------------------------------------------------------|
| Inventors:                 | Weichselbaum      and Kufe                                                                                                              |
| Application      Number:   | 60/604,251                                                                                                                              |
| File      Date:            | 8-25-04                                                                                                                                 |
| University      Reference: | 1250                                                                                                                                    |
| DFCI      Reference:       | 1021                                                                                                                                    |

|   | 4. | Schedule      A shall be amended todelete:  "*" |
|--------|----|-----------------------------------------------------------|

|   | 5. | Schedule      A, 24. shall be replaced with:  "*" |
|--------|----|-------------------------------------------------------------|

| University |                    | GenVec,      inc. |
|------------|-------------------------|-------------------|
|       |                    |              |   |   |
| By:        |                    |              | By: |   |
|       |                    |              |   |   |
| Title:     |   Director, UCTech |              | Title: |   SVP |
|       |                    |              |   |   |
| Date:      |   4/26/05          |              | Date: | 4/20/05 |

| DFCI   |                                  |   |
|--------|---------------------------------------|--------|
|   |                                  |   |
| By:    |                                  |   |
|   | Anthony      A. delCampo, M.B.A.      |   |
| Title: | Vice      President                   |   |
|   | Research      and Technology Ventures |   |
|   | Dana      Farber Cancer Institute     |   |
|   |                                  |   |
| Date:  | 5/5/05                                |   |

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