SEC Exhibit



EXHIBIT 10.2
[***] indicates material has been omitted pursuant to a request for confidential treatment filed with the Securities and Exchange Commission. A complete copy of this agreement, including redacted portions so indicated, has been separately filed with the Securities and Exchange Commission. 	
		
	12th January  2016    
	

	 

	 

	LDR Medical SAS

	Hotel de Bureaux 1,

	4 rue Gustave Eiffel,

	10430 Rosieres-Pres-Troyes

	France




Dear Sirs,


Letter of Amendment in respect of the Supply Agreement between Invibio Ltd and dated LDR Medical SAS dated 1st October 2014 (the “Agreement”.)


Following our discussions we are writing to confirm that pursuant to clause 9.1 of the Agreement we have agreed to make the following amendment to the Agreement from the date of this Letter of amendment:


1.    Schedule 2 shall be amended to include the following additional Buyer Products as follows:
	
			
	Range
	Commercial reference
	Commercial designation

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	Invibio Ltd.     
Victrex Technology Centre, Hillhouse International  
Thornton-Cleveleys, Lancashire, UK FY5 4QD                                                                 
	Tel     +44 (0) 1253 898000
Fax     +44 (0) 1253 898001
Email   info@invibio.com
	Invibio.com

	Invibio® is a registered trademark of Invibio Ltd. Registered in England and Wales No. 4088050 at the above address
















	
			
	 
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	Invibio Ltd.     
Victrex Technology Centre, Hillhouse International  
Thornton-Cleveleys, Lancashire, UK FY5 4QD                                                                 
	Tel     +44 (0) 1253 898000
Fax     +44 (0) 1253 898001
Email   info@invibio.com
	Invibio.com

	Invibio® is a registered trademark of Invibio Ltd. Registered in England and Wales No. 4088050 at the above address




[***] Portions of this page have been omitted pursuant to a request for confidential treatment and filed separately with the Securities and Exchange Commission.







	
			
	 
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	Invibio Ltd.     
Victrex Technology Centre, Hillhouse International  
Thornton-Cleveleys, Lancashire, UK FY5 4QD                                                                 
	Tel     +44 (0) 1253 898000
Fax     +44 (0) 1253 898001
Email   info@invibio.com
	Invibio.com

	Invibio® is a registered trademark of Invibio Ltd. Registered in England and Wales No. 4088050 at the above address




[***] Portions of this page have been omitted pursuant to a request for confidential treatment and filed separately with the Securities and Exchange Commission.







	
			
	 
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	Invibio Ltd.     
Victrex Technology Centre, Hillhouse International  
Thornton-Cleveleys, Lancashire, UK FY5 4QD                                                                 
	Tel     +44 (0) 1253 898000
Fax     +44 (0) 1253 898001
Email   info@invibio.com
	Invibio.com

	Invibio® is a registered trademark of Invibio Ltd. Registered in England and Wales No. 4088050 at the above address




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	Invibio Ltd.     
Victrex Technology Centre, Hillhouse International  
Thornton-Cleveleys, Lancashire, UK FY5 4QD                                                                 
	Tel     +44 (0) 1253 898000
Fax     +44 (0) 1253 898001
Email   info@invibio.com
	Invibio.com

	Invibio® is a registered trademark of Invibio Ltd. Registered in England and Wales No. 4088050 at the above address




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	Invibio Ltd.     
Victrex Technology Centre, Hillhouse International  
Thornton-Cleveleys, Lancashire, UK FY5 4QD                                                                 
	Tel     +44 (0) 1253 898000
Fax     +44 (0) 1253 898001
Email   info@invibio.com
	Invibio.com

	Invibio® is a registered trademark of Invibio Ltd. Registered in England and Wales No. 4088050 at the above address




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	Invibio Ltd.     
Victrex Technology Centre, Hillhouse International  
Thornton-Cleveleys, Lancashire, UK FY5 4QD                                                                 
	Tel     +44 (0) 1253 898000
Fax     +44 (0) 1253 898001
Email   info@invibio.com
	Invibio.com

	Invibio® is a registered trademark of Invibio Ltd. Registered in England and Wales No. 4088050 at the above address




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	Invibio Ltd.     
Victrex Technology Centre, Hillhouse International  
Thornton-Cleveleys, Lancashire, UK FY5 4QD                                                                 
	Tel     +44 (0) 1253 898000
Fax     +44 (0) 1253 898001
Email   info@invibio.com
	Invibio.com

	Invibio® is a registered trademark of Invibio Ltd. Registered in England and Wales No. 4088050 at the above address




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	Invibio Ltd.     
Victrex Technology Centre, Hillhouse International  
Thornton-Cleveleys, Lancashire, UK FY5 4QD                                                                 
	Tel     +44 (0) 1253 898000
Fax     +44 (0) 1253 898001
Email   info@invibio.com
	Invibio.com

	Invibio® is a registered trademark of Invibio Ltd. Registered in England and Wales No. 4088050 at the above address




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	Invibio Ltd.     
Victrex Technology Centre, Hillhouse International  
Thornton-Cleveleys, Lancashire, UK FY5 4QD                                                                 
	Tel     +44 (0) 1253 898000
Fax     +44 (0) 1253 898001
Email   info@invibio.com
	Invibio.com

	Invibio® is a registered trademark of Invibio Ltd. Registered in England and Wales No. 4088050 at the above address




[***] Portions of this page have been omitted pursuant to a request for confidential treatment and filed separately with the Securities and Exchange Commission.







	
			
	 
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	Invibio Ltd.     
Victrex Technology Centre, Hillhouse International  
Thornton-Cleveleys, Lancashire, UK FY5 4QD                                                                 
	Tel     +44 (0) 1253 898000
Fax     +44 (0) 1253 898001
Email   info@invibio.com
	Invibio.com

	Invibio® is a registered trademark of Invibio Ltd. Registered in England and Wales No. 4088050 at the above address




[***] Portions of this page have been omitted pursuant to a request for confidential treatment and filed separately with the Securities and Exchange Commission.







	
			
	 
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	Invibio Ltd.     
Victrex Technology Centre, Hillhouse International  
Thornton-Cleveleys, Lancashire, UK FY5 4QD                                                                 
	Tel     +44 (0) 1253 898000
Fax     +44 (0) 1253 898001
Email   info@invibio.com
	Invibio.com

	Invibio® is a registered trademark of Invibio Ltd. Registered in England and Wales No. 4088050 at the above address




[***] Portions of this page have been omitted pursuant to a request for confidential treatment and filed separately with the Securities and Exchange Commission.







	
			
	 
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	Invibio Ltd.     
Victrex Technology Centre, Hillhouse International  
Thornton-Cleveleys, Lancashire, UK FY5 4QD                                                                 
	Tel     +44 (0) 1253 898000
Fax     +44 (0) 1253 898001
Email   info@invibio.com
	Invibio.com

	Invibio® is a registered trademark of Invibio Ltd. Registered in England and Wales No. 4088050 at the above address




[***] Portions of this page have been omitted pursuant to a request for confidential treatment and filed separately with the Securities and Exchange Commission.







	
			
	 
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	Invibio Ltd.     
Victrex Technology Centre, Hillhouse International  
Thornton-Cleveleys, Lancashire, UK FY5 4QD                                                                 
	Tel     +44 (0) 1253 898000
Fax     +44 (0) 1253 898001
Email   info@invibio.com
	Invibio.com

	Invibio® is a registered trademark of Invibio Ltd. Registered in England and Wales No. 4088050 at the above address




[***] Portions of this page have been omitted pursuant to a request for confidential treatment and filed separately with the Securities and Exchange Commission.







	
			
	 
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	Invibio Ltd.     
Victrex Technology Centre, Hillhouse International  
Thornton-Cleveleys, Lancashire, UK FY5 4QD                                                                 
	Tel     +44 (0) 1253 898000
Fax     +44 (0) 1253 898001
Email   info@invibio.com
	Invibio.com

	Invibio® is a registered trademark of Invibio Ltd. Registered in England and Wales No. 4088050 at the above address




[***] Portions of this page have been omitted pursuant to a request for confidential treatment and filed separately with the Securities and Exchange Commission.







	
			
	 
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	Invibio Ltd.     
Victrex Technology Centre, Hillhouse International  
Thornton-Cleveleys, Lancashire, UK FY5 4QD                                                                 
	Tel     +44 (0) 1253 898000
Fax     +44 (0) 1253 898001
Email   info@invibio.com
	Invibio.com

	Invibio® is a registered trademark of Invibio Ltd. Registered in England and Wales No. 4088050 at the above address




[***] Portions of this page have been omitted pursuant to a request for confidential treatment and filed separately with the Securities and Exchange Commission.







	
			
	 
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	Invibio Ltd.     
Victrex Technology Centre, Hillhouse International  
Thornton-Cleveleys, Lancashire, UK FY5 4QD                                                                 
	Tel     +44 (0) 1253 898000
Fax     +44 (0) 1253 898001
Email   info@invibio.com
	Invibio.com

	Invibio® is a registered trademark of Invibio Ltd. Registered in England and Wales No. 4088050 at the above address




[***] Portions of this page have been omitted pursuant to a request for confidential treatment and filed separately with the Securities and Exchange Commission.







	
			
	 
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	Invibio Ltd.     
Victrex Technology Centre, Hillhouse International  
Thornton-Cleveleys, Lancashire, UK FY5 4QD                                                                 
	Tel     +44 (0) 1253 898000
Fax     +44 (0) 1253 898001
Email   info@invibio.com
	Invibio.com

	Invibio® is a registered trademark of Invibio Ltd. Registered in England and Wales No. 4088050 at the above address




[***] Portions of this page have been omitted pursuant to a request for confidential treatment and filed separately with the Securities and Exchange Commission.







	
			
	 
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	Invibio Ltd.     
Victrex Technology Centre, Hillhouse International  
Thornton-Cleveleys, Lancashire, UK FY5 4QD                                                                 
	Tel     +44 (0) 1253 898000
Fax     +44 (0) 1253 898001
Email   info@invibio.com
	Invibio.com

	Invibio® is a registered trademark of Invibio Ltd. Registered in England and Wales No. 4088050 at the above address




[***] Portions of this page have been omitted pursuant to a request for confidential treatment and filed separately with the Securities and Exchange Commission.







	
			
	 
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	Invibio Ltd.     
Victrex Technology Centre, Hillhouse International  
Thornton-Cleveleys, Lancashire, UK FY5 4QD                                                                 
	Tel     +44 (0) 1253 898000
Fax     +44 (0) 1253 898001
Email   info@invibio.com
	Invibio.com

	Invibio® is a registered trademark of Invibio Ltd. Registered in England and Wales No. 4088050 at the above address




[***] Portions of this page have been omitted pursuant to a request for confidential treatment and filed separately with the Securities and Exchange Commission.







	
			
	 
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	Invibio Ltd.     
Victrex Technology Centre, Hillhouse International  
Thornton-Cleveleys, Lancashire, UK FY5 4QD                                                                 
	Tel     +44 (0) 1253 898000
Fax     +44 (0) 1253 898001
Email   info@invibio.com
	Invibio.com

	Invibio® is a registered trademark of Invibio Ltd. Registered in England and Wales No. 4088050 at the above address




[***] Portions of this page have been omitted pursuant to a request for confidential treatment and filed separately with the Securities and Exchange Commission.







	
			
	 
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	Invibio Ltd.     
Victrex Technology Centre, Hillhouse International  
Thornton-Cleveleys, Lancashire, UK FY5 4QD                                                                 
	Tel     +44 (0) 1253 898000
Fax     +44 (0) 1253 898001
Email   info@invibio.com
	Invibio.com

	Invibio® is a registered trademark of Invibio Ltd. Registered in England and Wales No. 4088050 at the above address




[***] Portions of this page have been omitted pursuant to a request for confidential treatment and filed separately with the Securities and Exchange Commission.







	
			
	 
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	Invibio Ltd.     
Victrex Technology Centre, Hillhouse International  
Thornton-Cleveleys, Lancashire, UK FY5 4QD                                                                 
	Tel     +44 (0) 1253 898000
Fax     +44 (0) 1253 898001
Email   info@invibio.com
	Invibio.com

	Invibio® is a registered trademark of Invibio Ltd. Registered in England and Wales No. 4088050 at the above address




[***] Portions of this page have been omitted pursuant to a request for confidential treatment and filed separately with the Securities and Exchange Commission.







	
			
	 
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	Invibio Ltd.     
Victrex Technology Centre, Hillhouse International  
Thornton-Cleveleys, Lancashire, UK FY5 4QD                                                                 
	Tel     +44 (0) 1253 898000
Fax     +44 (0) 1253 898001
Email   info@invibio.com
	Invibio.com

	Invibio® is a registered trademark of Invibio Ltd. Registered in England and Wales No. 4088050 at the above address




[***] Portions of this page have been omitted pursuant to a request for confidential treatment and filed separately with the Securities and Exchange Commission.







	
			
	 
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	Invibio Ltd.     
Victrex Technology Centre, Hillhouse International  
Thornton-Cleveleys, Lancashire, UK FY5 4QD                                                                 
	Tel     +44 (0) 1253 898000
Fax     +44 (0) 1253 898001
Email   info@invibio.com
	Invibio.com

	Invibio® is a registered trademark of Invibio Ltd. Registered in England and Wales No. 4088050 at the above address




[***] Portions of this page have been omitted pursuant to a request for confidential treatment and filed separately with the Securities and Exchange Commission.







	
			
	 
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	Invibio Ltd.     
Victrex Technology Centre, Hillhouse International  
Thornton-Cleveleys, Lancashire, UK FY5 4QD                                                                 
	Tel     +44 (0) 1253 898000
Fax     +44 (0) 1253 898001
Email   info@invibio.com
	Invibio.com

	Invibio® is a registered trademark of Invibio Ltd. Registered in England and Wales No. 4088050 at the above address




[***] Portions of this page have been omitted pursuant to a request for confidential treatment and filed separately with the Securities and Exchange Commission.







	
			
	 
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	Invibio Ltd.     
Victrex Technology Centre, Hillhouse International  
Thornton-Cleveleys, Lancashire, UK FY5 4QD                                                                 
	Tel     +44 (0) 1253 898000
Fax     +44 (0) 1253 898001
Email   info@invibio.com
	Invibio.com

	Invibio® is a registered trademark of Invibio Ltd. Registered in England and Wales No. 4088050 at the above address




[***] Portions of this page have been omitted pursuant to a request for confidential treatment and filed separately with the Securities and Exchange Commission.







	
			
	 
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	Invibio Ltd.     
Victrex Technology Centre, Hillhouse International  
Thornton-Cleveleys, Lancashire, UK FY5 4QD                                                                 
	Tel     +44 (0) 1253 898000
Fax     +44 (0) 1253 898001
Email   info@invibio.com
	Invibio.com

	Invibio® is a registered trademark of Invibio Ltd. Registered in England and Wales No. 4088050 at the above address




[***] Portions of this page have been omitted pursuant to a request for confidential treatment and filed separately with the Securities and Exchange Commission.







	
			
	 
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	Invibio Ltd.     
Victrex Technology Centre, Hillhouse International  
Thornton-Cleveleys, Lancashire, UK FY5 4QD                                                                 
	Tel     +44 (0) 1253 898000
Fax     +44 (0) 1253 898001
Email   info@invibio.com
	Invibio.com

	Invibio® is a registered trademark of Invibio Ltd. Registered in England and Wales No. 4088050 at the above address




[***] Portions of this page have been omitted pursuant to a request for confidential treatment and filed separately with the Securities and Exchange Commission.







	
			
	 
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	Invibio Ltd.     
Victrex Technology Centre, Hillhouse International  
Thornton-Cleveleys, Lancashire, UK FY5 4QD                                                                 
	Tel     +44 (0) 1253 898000
Fax     +44 (0) 1253 898001
Email   info@invibio.com
	Invibio.com

	Invibio® is a registered trademark of Invibio Ltd. Registered in England and Wales No. 4088050 at the above address




[***] Portions of this page have been omitted pursuant to a request for confidential treatment and filed separately with the Securities and Exchange Commission.







	
			
	 
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	Invibio Ltd.     
Victrex Technology Centre, Hillhouse International  
Thornton-Cleveleys, Lancashire, UK FY5 4QD                                                                 
	Tel     +44 (0) 1253 898000
Fax     +44 (0) 1253 898001
Email   info@invibio.com
	Invibio.com

	Invibio® is a registered trademark of Invibio Ltd. Registered in England and Wales No. 4088050 at the above address




[***] Portions of this page have been omitted pursuant to a request for confidential treatment and filed separately with the Securities and Exchange Commission.







	
			
	 
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	Invibio Ltd.     
Victrex Technology Centre, Hillhouse International  
Thornton-Cleveleys, Lancashire, UK FY5 4QD                                                                 
	Tel     +44 (0) 1253 898000
Fax     +44 (0) 1253 898001
Email   info@invibio.com
	Invibio.com

	Invibio® is a registered trademark of Invibio Ltd. Registered in England and Wales No. 4088050 at the above address




[***] Portions of this page have been omitted pursuant to a request for confidential treatment and filed separately with the Securities and Exchange Commission.







	
			
	 
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	Invibio Ltd.     
Victrex Technology Centre, Hillhouse International  
Thornton-Cleveleys, Lancashire, UK FY5 4QD                                                                 
	Tel     +44 (0) 1253 898000
Fax     +44 (0) 1253 898001
Email   info@invibio.com
	Invibio.com

	Invibio® is a registered trademark of Invibio Ltd. Registered in England and Wales No. 4088050 at the above address




[***] Portions of this page have been omitted pursuant to a request for confidential treatment and filed separately with the Securities and Exchange Commission.







	
			
	 
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	Invibio Ltd.     
Victrex Technology Centre, Hillhouse International  
Thornton-Cleveleys, Lancashire, UK FY5 4QD                                                                 
	Tel     +44 (0) 1253 898000
Fax     +44 (0) 1253 898001
Email   info@invibio.com
	Invibio.com

	Invibio® is a registered trademark of Invibio Ltd. Registered in England and Wales No. 4088050 at the above address




[***] Portions of this page have been omitted pursuant to a request for confidential treatment and filed separately with the Securities and Exchange Commission.







	
			
	 
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	Invibio Ltd.     
Victrex Technology Centre, Hillhouse International  
Thornton-Cleveleys, Lancashire, UK FY5 4QD                                                                 
	Tel     +44 (0) 1253 898000
Fax     +44 (0) 1253 898001
Email   info@invibio.com
	Invibio.com

	Invibio® is a registered trademark of Invibio Ltd. Registered in England and Wales No. 4088050 at the above address




[***] Portions of this page have been omitted pursuant to a request for confidential treatment and filed separately with the Securities and Exchange Commission.







	
			
	 
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	Invibio Ltd.     
Victrex Technology Centre, Hillhouse International  
Thornton-Cleveleys, Lancashire, UK FY5 4QD                                                                 
	Tel     +44 (0) 1253 898000
Fax     +44 (0) 1253 898001
Email   info@invibio.com
	Invibio.com

	Invibio® is a registered trademark of Invibio Ltd. Registered in England and Wales No. 4088050 at the above address




[***] Portions of this page have been omitted pursuant to a request for confidential treatment and filed separately with the Securities and Exchange Commission.












All capitalised terms used in this Letter shall have the same meaning as when used in the Agreement.


Except as expressly provided in this Letter all terms, conditions and provisions of the 
Agreement and subsequent amendments shall remain in full force and effect.


This Letter and all matters arising from or connected with it are governed by English law.


In WITESS WHEREOF, the parties have confirmed their acceptance of the contents of this Letter.


	
							
	Signature:
	 
	 
	 
	Signature:
	 
	 

	 
	 
	 
	 
	 
	 
	 

	 
	 
	 
	 
	 
	 
	 

	/s/ Nicola Shilton
	 
	/s/ Patrick Richard

	A duly authorized representative
	 
	A duly authorized representative

	for and on behalf of Invibio Ltd
	 
	for and on behalf of Medical SAS

	 
	 
	 
	 
	 
	 
	 

	 
	 
	 
	 
	 
	 
	 

	Name:
	 
	Nicola Shilton
	 
	Name:
	 
	Patrick Richard

	 
	 
	 
	 
	 
	 
	 

	Position:
	 
	Contracts Manager
	 
	Position:
	 
	Vice-President & Managing Director

	 
	 
	 
	 
	 
	 
	 

	Date:
	 
	February 16, 2016
	 
	Date:
	 
	February 8, 2016










	
			
	Invibio Ltd.     
Victrex Technology Centre, Hillhouse International  
Thornton-Cleveleys, Lancashire, UK FY5 4QD                                                                 
	Tel     +44 (0) 1253 898000
Fax     +44 (0) 1253 898001
Email   info@invibio.com
	Invibio.com

	Invibio® is a registered trademark of Invibio Ltd. Registered in England and Wales No. 4088050 at the above address