|     |   |                                                                                   |
|----------|--------|----------------------------------------------------------------------------------------|
| ☑ |   | QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIESEXCHANGE ACT OF 1934 |

|     |   |                                                                                    |
|----------|--------|-----------------------------------------------------------------------------------------|
| ☐ |   | TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIESEXCHANGE ACT OF 1934 |

|                                                          |   |                                |
|---------------------------------------------------------------|--------|-------------------------------------|
|                                                          |   |
| Nevada                                                        |   | 20-5093315                          |
| (State or other jurisdiction ofincorporation or organization) |   | (I.R.S. EmployerIdentification No.) |

|                                          |            |
|-----------------------------------------------|-----------------|
| Large accelerated filer                       |  [  ] | Accelerated filer | [  ] |
| Non-Accelerated filer                         |  [  ] | Smaller reporting company | [X] |
| (do not check if a smaller reporting company) |  [  ] | Emerging growth company | [ ] |

| Exhibit   |   |                                                                                                                                                                                                                                                  |
|-----------|--------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| Number    |   | Description                                                                                                                                                                                                                                           |
|      |   |                                                                                                                                                                                                                                                  |
| 10.1 +    |   | Exclusive License and Sublicense Agreement by and between VistaGenTherapeutics. Inc and Apollo Biologics LP, effective December 9,2016, filed herewith.                                                                                               |
|      |   |                                                                                                                                                                                                                                                  |
| 10.2 +*   |   | Patent License Amendment Agreement between VistaGen TherapeuticsInc. and University Health Network effective December 9,2016.                                                                                                                         |
|      |   |                                                                                                                                                                                                                                                  |
| 31.1**    |   | Certification of the Principal Executive Officer required byRule 13a-14(a) under the Securities Exchange Act of 1934, asamended, as adopted pursuant to Section 302 of theSarbanes-Oxley Act of 2002                                        |
|      |   |                                                                                                                                                                                                                                                  |
| 31.2**    |   | Certification of the Principal Financial Officer required byRule 13a-14(a) under the Securities Exchange Act of 1934, asamended, as adopted pursuant to Section 302 of theSarbanes-Oxley Act of 2002                                        |
|      |   |                                                                                                                                                                                                                                                  |
| 32**      |   | Certification of the Principal Executive and Financial Officersrequired by Rule 13a-14(b) and Section 1350 ofChapter 63 of Title 18 of the United States Code, as adoptedpursuant to Section 906 of the Sarbanes-Oxley Act of2002 |
|      |   |                                                                                                                                                                                                                                                  |
| 101.INS** |   | XBRL Instance Document                                                                                                                                                                                                                                |
| 101.SCH** |   | XBRL Taxonomy Extension Schema                                                                                                                                                                                                                        |
| 101.CAL** |   | XBRL Taxonomy Extension Calculation Linkbase                                                                                                                                                                                                          |
| 101.DEF** |   | XBRL Taxonomy Extension Definition Linkbase                                                                                                                                                                                                           |
| 101.LAB** |   | XBRL Taxonomy Extension Label Linkbase                                                                                                                                                                                                                |
| 101.PRE** |   | XBRL Taxonomy Extension Presentation Linkbase                                                                                                                                                                                                         |

|   |                                                                                                                              |   |   |   |
|--------|-----------------------------------------------------------------------------------------------------------------------------------|--------|--------|--------|
|   | VISTAGEN THERAPEUTICS, INC.  /s/ Shawn K.SinghShawn K. SinghChief Executive Officer (Principal Executive Officer)  |   |
|   | /s/ Jerrold D.Dotson                                                                                                              |   |
|   | Jerrold D. Dotson                                                                                                                 |   |
|   | Chief Financial Officer (Principal Financial and AccountingOfficer                                                                |   |
|   |