<PAGE>

EXHIBIT 4.2

  THIS NOTE AND THE SHARES OF COMMON STOCK ISSUABLE UPON CONVERSION OF THE NOTE
  HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED, OR ANY
  APPLICABLE STATE SECURITIES LAWS. NEITHER THE NOTE NOR SUCH SHARES OF COMMON
   STOCK MAY BE OFFERED FOR SALE, SOLD, TRANSFERRED, PLEDGED OR HYPOTHECATED
    WITHOUT AN EFFECTIVE REGISTRATION STATEMENT UNDER THE SECURITIES ACT AND
      UNDER ANY APPLICABLE STATE SECURITIES LAWS, OR AN OPINION OF COUNSEL,
     SATISFACTORY TO THE COMPANY, THAT AN EXEMPTION FROM SUCH REGISTRATION
                                 IS AVAILABLE.


                              AETHLON MEDICAL, INC.

                          10% SERIES A CONVERTIBLE NOTE



No. 1                                                                   $580,000


         FOR VALUE RECEIVED, Aethlon Medical, Inc., a Nevada corporation (the
"Company"), promises to pay to Ellen R. Weiner Family Revocable Trust, whose
address is 4004 East Lupine Avenue, Phoenix, Arizona 85028, or registered
assigns (the "Holder"), the sum of Five Hundred and Eighty Thousand Dollars
($580,000) in lawful money of the United States of America on or before the
Maturity Date as defined herein, with all Interest thereon as defined and
specified herein. This Note includes various advances (the "Advances") that the
Holder has made to the Company since July 2005. This Note replaces promissory
notes previously issued by the Company to the Holder prior to the Issue Date
respecting certain of those Advances and provides documentation for other
Advances for which no notes have yet been issued.

         1. INTEREST. This Note shall bear interest ("Interest") equal to ten
percent (10%) per annum on the unpaid principal balance, computed on a three
hundred sixty (360)-day year, during the term of the Note. Interest will accrue
on each Advance commencing on the date of the Advance, as set forth on Exhibit A
to this Note. The Company shall pay all Interest on or before the Maturity Date.
In no event shall the rate of Interest payable on this Note exceed the maximum
rate of Interest permitted to be charged under applicable law.

         2. PAYMENTS. All payments under this Note shall first be credited
against costs and expenses provided for in this Note, second to the payment of
any penalties, third to the payment of accrued and unpaid Interest, if any, and
the remainder shall be credited against principal. All payments due hereunder
shall be payable in legal tender of the United States of America, and in same
day funds delivered to Holder by cashier's check, certified check, bank wire
transfer or any other means of guaranteed funds to the mailing address provided
below, or at such other place as the Holder shall designate in writing for such
purpose from time to time. If a payment under this Note otherwise would become
due and payable on a Saturday, Sunday or legal holiday (any other day being a
"Business Day"), the due date of the payment shall be extended to the next
succeeding Business Day, and Interest, if any, shall be payable thereon during
such extension.

                                       1
<PAGE>

         3. PRE-PAYMENTS AND MATURITY DATE. This Note shall be due and payable
in full, including all accrued Interest thereon, on January 2, 2007 (the
"Maturity Date"). At any time on or prior to the Maturity Date, the Company
shall have the right to prepay this Note, in whole or in part, on ten (10) days'
advance notice to the Holder and subject to the right of the Holder to convert
in advance of such prepayment date and provided that on such prepayment date,
the Company will pay in respect of the redeemed Note cash equal to the face
amount plus accrued Interest on the Note (or portion thereof) redeemed. At any
time after the Maturity Date, the Company shall have the right to repay this
Note, in whole or in part, on ten (10) days' advance notice to the Holder and
subject to the right of the Holder to convert in advance of such repayment date.
The Company may prepay this Note at any time after issuance without penalty.

         4. EQUAL RANK. This Note represents one of a series of up to One
Million Dollars ($1,000,000) principal amount of 10% Series A Convertible Notes
(the "Notes") issued or to be issued by the Company. All Notes rank equally and
ratably without priority over one another.

         5. CONVERSION OF NOTE AND ISSUANCE OF WARRANTS.

                  5.1 CONVERSION OF NOTE/CONVERSION PRICE. This Note is
convertible, at the option of the Holder, into shares of the Company's Common
Stock (the "Common Stock") at any time after the Issue Date prior to the close
of business on the Business Day prior to the Maturity Date at the rate of $.20
per share (the "Conversion Price"), subject to adjustment as hereinafter
provided. No fractional shares will be issued. In lieu thereof, the Company will
pay cash for fractional share amounts equal to the fair market value of the
Common Stock as quoted as the closing bid price of the Common Stock on the date
of conversion.

                  5.2 ISSUANCE OF WARRANTS. Upon the conversion of this Note,
the Company will issue to the Holder a Common Stock Purchase Warrant (the
"Warrant") exercisable to purchase the same number of shares of Common Stock
into which this Note would be convertible on the Issue Date. The Warrant is
exercisable to purchase shares of Common Stock at the price of $.20 per share
and as otherwise specified in the Warrant.

                  5.3 LIMITATION ON CONVERSION RIGHTS. Notwithstanding any other
provision of Paragraph 5 to the contrary, the Holder shall not be entitled to
convert this Note, and any other outstanding Notes of this Series A issued to
the Holder that is convertible into Common Stock (the "Related Notes") in excess
of that number of shares of Common Stock which, upon giving effect to such
conversion, would cause the aggregate number of shares of Common Stock
beneficially owned by the Holder and its Affiliates to exceed 9.9% of the
outstanding shares of the Common Stock following such conversion. For purposes
of the foregoing provision, the aggregate number of shares of Common Stock
beneficially owned by the Holder and its Affiliates shall include the number of
shares of Common Stock beneficially owned and those shares issuable upon
conversion of this Note and all Related Notes with respect to which the
determination of such proviso is being made, but shall exclude the number of
shares of Common Stock that would be issuable upon (i) conversion of the
remaining principal amount of this Note and the Related Notes beneficially owned
by the Holder and its Affiliates and (ii) exercise or conversion of the
unexercised or unconverted portion of any other securities of the Company into
Common Stock beneficially owned by the Holder and its Affiliates that are
subject to a limitation on conversion or exercise analogous to the limitation
contained in this Note. For purposes of this Paragraph, in determining the
number of outstanding shares of Common Stock the Holder may rely on the number
of outstanding shares of Common Stock as reflected in (a) the Company's most


                                       2
<PAGE>

recent Form 10-Q or Form 10-K, as the case may be, or (b) more recent public
announcement by the Company or (c) any other written communication by the
Company or its Transfer Agent setting forth the number of shares of Common Stock
outstanding. Upon the reasonable written or oral request of the Holder, the
Company shall promptly confirm orally and in writing to the Holder the number of
shares of Common Stock then outstanding. In any case, the number of outstanding
shares of Common Stock shall be determined after giving effect to any
conversions, exercises or purchases by the Holder since the date as of which
such number of outstanding shares of Common Stock was reported. Except as
otherwise set forth herein, beneficial ownership shall be determined in
accordance with Section 13(d) of the Securities Exchange Act of 1934, as
amended. If the foregoing 9.9% limitation is ever reached and the Holder desires
to convert this Note or part thereof into equity, the Company will acknowledge
the conversion in writing, but not issue the Holder any additional shares of
Common Stock at that point. Under such circumstances the Holder will have the
right to receive additional shares of Common Stock as a result of the conversion
only at such point and to the extent that its beneficial ownership subsequently
becomes less than 9.9% and such issuance will not cause the Holder's beneficial
ownership to exceed 9.9%. Upon written notice to this effect given by the
Holder, the Company will issue such additional shares in accordance with
Paragraph 5.8, "Issuance of Certificate."

                  5.4 ADJUSTMENT BASED UPON STOCK DIVIDENDS, COMBINATION OF
SHARES OR RECAPITALIZATION. The Conversion Price shall be adjusted in the event
that the Company shall at any time (i) pay a stock dividend on the Common Stock;
(ii) subdivide its outstanding Common Stock into a greater number of shares;
(iii) combine its outstanding Common Stock into a smaller number of shares; (iv)
issue by reclassification of its Common Stock any other special capital stock of
the Company; or (v) distribute to all holders of Common Stock evidences of
indebtedness or assets (excluding cash dividends) or rights or warrants to
subscribe for Common Stock (other than those mentioned above). No adjustment of
the Conversion Price will be required until cumulative adjustments amount to One
Dollar ($1.00) per Note or more. Upon the occurrence of an event requiring
adjustment of the Conversion Price, and thereafter, the Holder, upon surrender
of this Note for conversion, shall be entitled to receive the number of shares
of Common Stock or other capital stock of the Company that the Holder would have
owned or have been entitled to receive after the happening of any of the events
described above had this Note been converted immediately prior to the happening
of such event.

                  5.5 ADJUSTMENT BASED UPON MERGER OR CONSOLIDATION. In case of
any consolidation or merger to which the Company is a party (other than a merger
in which the Company is the surviving entity and which does not result in any
reclassification of or change in the outstanding Common Stock of the Company),
or in case of any sale or conveyance to another person, firm, or corporation of
the property of the Company as an entirety or substantially as an entirety, the
Holder shall have the right to convert this Note into the kind and amount of
securities and property (including cash) receivable upon such consolidation,
merger, sale or conveyance by the Holder of the number of shares of Common Stock
into which such Note might have been converted immediately prior thereto.


                                       3
<PAGE>

                  5.6 EXERCISE OF CONVERSION PRIVILEGE.

                           5.6.1 The Conversion Privilege provided for in this
Note shall be exercisable by the Holder by written notice to the Company or its
successor and the surrender of this Note in exchange for the number of shares
(or other securities and property, including cash, in the event of an adjustment
of the Conversion Price) into which this Note is convertible based upon the
Conversion Price.

                           5.6.2 The Holder's conversion right set forth in this
Paragraph 5.5 may be exercised at any time and from time to time but prior to
payment in full of the principal amount of the accrued interest on this Note.
Conversion rights will expire at the close of business on the Business Day prior
to the Maturity Date or redemption date of this Note.

                           5.6.3 The Holder may exercise the right to convert
all or any portion of the principal amount and accrued Interest on this Note by
delivery of (i) this Note and (ii) a completed Conversion Notice in the form
attached as Exhibit B on a Business Day to the Company's principal executive
offices. Such conversion shall be deemed to have been made immediately prior to
the close of business on the Business Day of such delivery a conversion notice
(the "Conversion Date"), and the Holder shall be treated for all purposes as the
record holder of the shares of Common Stock into which this Note is converted as
of such date.

                           5.6.4 Upon conversion of the entire principal amount
and accrued Interest of this Note and the delivery of shares of Common Stock
upon conversion of this Note, except as otherwise provided in Paragraph 22,
"Representations and Warranties to Survive Closing," the Company shall be
forever released from all of its obligations and liabilities under this Note.

                  5.7 CORPORATE STATUS OF COMMON STOCK TO BE ISSUED. All Common
Stock (or other securities in the event of an adjustment of the Conversion
Price) which may be issued upon the conversion of this Note shall, upon
issuance, be fully paid and nonassessable.

                  5.8 ISSUANCE OF CERTIFICATE. Upon the conversion of this Note,
the Company shall, within five (5) Business Days of such conversion, issue to
the Holder a certificate or certificates representing the number of shares of
the Common Stock (or other securities in the event of an adjustment of the
Conversion Price) to which the conversion relates.

         6. STATUS OF HOLDER OF NOTE. This Note shall not entitle the Holder to
any voting rights or other rights as a shareholder of the Company or to any
rights whatsoever except the rights herein expressed, and no dividends shall be
payable or accrue in respect of this Note or the securities issuable upon the
conversion hereof unless and until this Note shall be converted. Upon the
conversion of this Note, the Holder shall, to the extent permitted by law, be
deemed to be the holder of record of the shares of Common Stock and Warrants
issuable upon such conversion, notwithstanding that the stock transfer books of
the Company shall then be closed or that the certificates representing such
shares of Common Stock and Warrants shall not then be actually delivered.

         7. RESERVE OF SHARES OF COMMON STOCK. The Company shall reserve out of
its authorized shares of Common Stock, and other securities in the event of an
adjustment of the Conversion Price, a number of shares sufficient to enable it
to comply with its obligation to issue shares of Common Stock, and other
securities in the event of an adjustment of the Conversion Price, upon the
conversion of this Note.

                                       4
<PAGE>

         8. TRANSFER RESTRICTIONS; EXEMPTION FROM REGISTRATION.

                  8.1 The Holder agrees that (i) this Note and the shares of
Common Stock issuable upon conversion have not been registered under the Act and
may not be sold or transferred without registration under the Act or unless an
exemption from such registration is available; (ii) the Holder has acquired this
Note and will acquire the Common Stock for its own account for investment
purposes only and not with a view toward resale or distribution; and (iii) if a
registration statement that includes the Common Stock is not effective at the
time Common Stock is issued to Holder upon conversion under this Note, and the
Common Stock is not exempt from registration under Rule 144, then the Common
Stock shall be inscribed with the following legend:

         THE SECURITIES REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED
UNDER THE SECURITIES ACT OF 1933, AS AMENDED, OR APPLICABLE STATE SECURITIES
LAWS. THE SECURITIES HAVE BEEN ACQUIRED FOR INVESTMENT AND MAY NOT BE OFFERED
FOR SALE, SOLD, TRANSFERRED OR ASSIGNED IN THE ABSENCE OF AN EFFECTIVE
REGISTRATION STATEMENT FOR THE SECURITIES UNDER THE SECURITIES ACT OF 1933, AS
AMENDED, OR APPLICABLE STATE SECURITIES LAWS, OR AN OPINION OF HOLDER'S COUNSEL,
IN A CUSTOMARY FORM, THAT REGISTRATION IS NOT REQUIRED UNDER SAID ACT OR
APPLICABLE STATE SECURITIES LAWS OR UNLESS SOLD PURSUANT TO RULE 144 UNDER SAID
ACT.

                  8.2 If an opinion of counsel of Holder provides that
registration is not required for the proposed conversion or transfer of this
Note or the proposed transfer of the shares of Common Stock issuable upon
conversion and that the proposed conversion or transfer in the absence of
registration would require the Company to take any action including executing
and filing forms or other documents with the Securities and Exchange Commission
(the "SEC") or any state securities agency, or delivering to the Holder any form
or document in order to establish the right of the Holder to effectuate the
proposed conversion or transfer, the Company agrees promptly, at its expense, to
take any such action; and provided, further, that the Company will reimburse the
Holder in full for any expenses (including but not limited to the fees and
disbursements of such counsel, but excluding brokers' commissions) incurred by
the Holder or owner of shares of Common Stock on his, her or its behalf in
connection with such conversion or transfer of the Note or transfer of the
shares of Common Stock.

         9. REGISTRATION RIGHTS.

                  The Holders of the Notes and Warrants or Common Stock issued
to the Holder without an effective Registration Statement under the Act (the
"Restricted Shares") shall have the right, under the terms of a Registration
Rights Agreement between the Holder and the Company, to cause the Company
register the Common Stock underlying the Notes and Warrants (the "Underlying
Common Stock") or Restricted Shares in a Registration Statement under the
Securities Act 1993, as amended ("Act"), filed by the Company with the SEC.

                                       5
<PAGE>

         10. RULE 144

                  If the Company (a) has or registers a class of securities
under Section 12 of the Securities Exchange Act of 1934, as amended (the
"Exchange Act") or (b) has or commences to file reports under Section 13 or
15(d) of the Exchange Act, then, at the request of any Holder who proposes to
sell securities in compliance with Rule 144 of the SEC, the Company will (i)
forthwith furnish to such holder a written statement of compliance with the
filing requirements of the SEC as set forth in Rule 144, as such rules may be
amended from time to time and (ii) make available to the public and such Holder
such information and take such other action as is requested by the Holder to
enable the Holder to make sales pursuant to Rule 144.

         11. DEFAULT. The Company shall perform its obligations and covenants
hereunder and in each and every other agreement between the Company and Holder
pertaining to the Indebtedness evidenced hereby. The following provisions shall
apply upon failure of the Company so to perform.

                  11.1 EVENT OF DEFAULT. Any of the following events shall
constitute an "Event of Default" hereunder:

                           11.1.1 Failure by the Company to pay principal of any
of the Notes when due and payable on the Maturity Date;

                           11.1.2 Failure of the Company to pay Interest when
due hereunder, which failure continues for a period of thirty (30) days after
the due date of the amount involved; or

                           11.1.3 Failure of the Company to perform any of the
covenants, conditions, provisions or agreements contained herein, or in any
other agreement between the Company and Holder, which failure continues for a
period of thirty (30) days after notice of default has been given to the Company
by the Holders of not less than twenty-five percent (25%) of the principal
amount of the Notes then outstanding; provided, however, that if the nature of
the Company's obligation is such that more than thirty (30) days are required
for performance, then an Event of Default shall not occur if the Company
commences performance within such thirty (30) day period and thereafter
diligently prosecutes the same to completion; or

                           11.1.4 The entry of an order for relief under Federal
Bankruptcy Code as to the Company or entry of any order appointing a receiver or
trustee for the Company or approving a petition in reorganization or other
similar relief under bankruptcy or similar laws in the United States of America
or any other competent jurisdiction, and if such order, if involuntary, is not
satisfied or withdrawn within sixty (60) days after entry thereof; or the filing
of a petition by the Company seeking any of the foregoing, or consenting
thereto; or the filing of a petition to take advantage of any debtor's act; or
making a general assignment for the benefit of creditors; or admitting in
writing inability to pay debts as they mature.

                  11.2 ACCELERATION. Upon any Event of Default (in addition to
any other rights or remedies provided for under this Note), at the option of the
Holders of not less than twenty-five percent (25%) of the principal amount of
the Notes then outstanding, all sums evidenced hereby, including all principal,
Interest, fees and all other amounts due hereunder, shall become immediately due
and payable. If an Event of Default in the payment of principal or Interest
should occur and be continuing with respect to the Note, any one or more holders
of the Notes then outstanding may declare the principal of the Notes to be
immediately due and payable. In the Event of a Default due to a breach of any
other covenant or term, Holders representing twenty-five percent (25%) of the
principal amount of the Notes may take action to accelerate the Notes.

                                       6
<PAGE>

                  11.3 NOTICE BY COMPANY. Upon the happening of any Event of
Default specified in this paragraph that is not cured within the respective
periods prescribed above, the Company will give prompt written notice thereof to
the Holder of this Note.

                  11.4 NO WAIVER. Failure of the Holder to exercise any option
hereunder shall not constitute a waiver of the right to exercise the same in the
event of any subsequent Event of Default, or in the event of continuance of any
existing Event of Default after demand or performance thereof.

                  11.5 DEFAULT INTEREST. Default Interest will accrue on an
unpaid principal or Interest due hereunder at the rate of fifteen percent (15%)
per annum upon the occurrence of any Event of Default until the Event of Default
is cured.

                  11.6 PURSUIT OF ANY REMEDY. No Holder of a Note may pursue any
remedy under the Notes unless (i) the Company shall have received written notice
of a continuing Event of Default from the Holder and (ii) the Company shall have
received a request from Holders of at least twenty-five percent (25%) of
principal amount of the Notes to pursue such remedy. The Holders of fifty-one
percent (51%) of principal amount of the Notes then outstanding have the right
to direct the time, method and place of conducting any proceeding for exercising
any remedy available to the Noteholders under the Notes.

         12. ASSIGNMENT, TRANSFER OR LOSS OF THE NOTE.

                  12.1 No Holder of this Note may assign, transfer, hypothecate
or sell all or any part of this Note or in any way alienate or encumber the Note
without the express written consent of the Company, the granting or denial of
which shall be within the absolute discretion of the Company. Any attempt to
effect such transfer without the consent of the Company shall be null and void.
The Company has not registered this Note under the Act or the applicable
securities laws of any state in reliance on exemptions from registration. Such
exemptions depend upon the investment intent of the Holder at the time he
acquires his Note. The Holder is acquiring this Note for his own account for
investment purposes only and not with a view toward distribution or resale of
such Note within the meaning of the Act and the applicable securities laws of
any state. The Company shall be under no duty to register the Note or to comply
with an exemption in connection with the sale, transfer or other disposition
under the applicable laws and regulations of the Act or the applicable
securities laws of any state. The Company may require the Holder to provide, at
his expense, an opinion of counsel satisfactory to the Company to the effect
that any proposed transfer or other assignment of the Note will not result in a
violation of the applicable federal or state securities laws or any other
applicable federal or state laws or regulations.

                                       7
<PAGE>

                  12.2 All expenses, including reasonable legal fees incurred by
the Company in connection with any permitted transfer, assignment or pledge of
this Note will be paid by the Holder requesting such transfer, assignment or
pledge.

                  12.3 Upon receipt of evidence reasonably satisfactory to the
Company of the loss, theft, destruction or mutilation of any Note and, in the
case of any such loss, theft or destruction of any Note, upon delivery of an
indemnity bond in such reasonable amount as the Company may determine (or, in
the case of any Note held by the original Noteholder, of an indemnity agreement
reasonably satisfactory to the Company), or, in the case of any such mutilation,
upon the surrender of such Note to the Company at is principal office for
cancellation, the Company at its expense will execute and deliver, in lieu
thereof, a new Note of like tenor, dated the date to which interest hereunder
shall have been paid on such lost, stolen, destroyed or mutilated Note.

                  12.4 Subject to Subparagraph 12.1 above, the Holder may, at
his option, either in person or by duly authorized attorney, surrender this Note
for registration of transfer at the principal office of the Company and, upon
payment of any expenses associated with the transfer, receive in exchange
therefor a Note or Notes, dated as of the date to which interest has been paid
on the Note so surrendered, each in the principal amount of $1,000 or any
multiple thereof, for the same aggregate unpaid principal amount as the Note so
surrendered and registered as payable to such person or persons as may be
designated by the Holder. Every Note surrendered for registration of transfer
shall be duly endorsed or shall be accompanied by a written instrument of
transfer duly executed by the Holder or his attorney duly authorized in writing.
Every Note, so made and delivered by the Company in exchange for any Note
surrendered, shall in all other respects be in the same form and have the same
terms as the Note surrendered. No transfer of any Note shall be valid unless
made in such manner at the principal office of the Company.

                  12.5 The Company may treat the person in whose name this Note
is registered as the owner and Holder of this Note for the purpose of receiving
payment of all principal of and all Interest on this Note, and for all other
purposes whatsoever, whether or not such Note shall be overdue and, except for
transfers effected in accordance with this subparagraph, the Company shall not
be affected by notice to the contrary.

         13. MODIFICATIONS AND AMENDMENTS. After notice given by the Company to
the Holders of all Notes at the time outstanding, the Company may from time to
time and at any time enter into an agreement or agreements supplemental to the
provisions of this Note for the purpose of adding any provisions to or changing
in any manner or eliminating any of the provisions of the Notes or of modifying
in any manner the rights of the Holders of the Notes; PROVIDED, HOWEVER, that no
such supplemental agreement, modification or amendment may, without the consent
of the holder of each Note then outstanding affected thereby, (i) reduce the
percentage of principal amount of Notes whose Holders may consent to an
amendment, supplement or waiver; (ii) reduce the rate or change the time for
payment of interest, including Default Interest, on any Note; (iii) reduce the
principal amount of any Note or change the Maturity Date of the Notes; (iv) make


                                       8
<PAGE>

any Note payable in money other than that stated in the Note; (v) impair the
right to institute suit for the enforcement of any payment of principal of, or
premium, if any, or interest on, any Note; (vi) make any change in the
percentage of principal amount of Notes necessary to waive compliance with
certain provisions of the Note; or (vii) waive a continuing default or Event of
Default in the payment of principal of, premium, if any, or Interest on the
Notes. The modifications and amendments of the Notes may be made by the Company
without the consent of any Holders of Notes in certain limited circumstances,
including (a) to cure any ambiguity, omission, defect or inconsistency, (b) to
provide for the assumption of the obligations of the Company under the Notes
upon the merger, consolidation or sale or other disposition of all or
substantially all of the assets of the Company, or (c) to make any change that
does not adversely affect the rights of any holder of Notes. The Holders of a
majority in aggregate principal amount of the Notes then outstanding may waive
any past default under the Notes, except a default in the payment of principal,
premium, if any, or Interest. Promptly after execution by the Company and
Holders of the Notes of a supplemental agreement pursuant to the provisions of
this paragraph, the Company shall deliver a copy of such supplemental agreement
to all Holders of the Notes at the time outstanding.

         14. NOTICES. All notices provided for herein shall be validly given if
in writing and delivered personally or sent by certified mail, postage prepaid,
to the office of the Company or such other address as the Company may from time
to time designate in writing sent by certified mail, postage prepaid, to the
Holder at his address set forth below or such other address as the Holder may
from time to time designate in writing to the Company by certified mail, postage
prepaid.

         15. USURY. All Interest, Default Interest, fees, charges, goods, things
in action or any other sums or things of value, or other contractual obligations
(collectively, the "Additional Sums") paid by the Company hereunder, whether
pursuant to this Note or otherwise, with respect to the Indebtedness evidenced
hereby, or any other document or instrument in any way pertaining to the
Indebtedness, which, under the laws of the State of California may be deemed to
be Interest with respect to such loan or Indebtedness, shall, for the purpose of
any laws of the State of California, which may limit the maximum amount of
Interest to be charged with respect to such loan or Indebtedness, be payable by
the Company as, and shall be deemed to be, Interest and for such purposes only,
the agreed upon and contracted rate of Interest shall be deemed to be increased
by the Additional Sums. Notwithstanding any provision of this Note to the
contrary, the total liability for payments in the nature of Interest under this
Note shall not exceed the limits imposed by applicable law. The Company shall
not assert a claim, and shall actively resist any attempts to compel it to
assert a claim, respecting a benefit under any present or future usury laws
against any Holder of this Note.

         16. BINDING EFFECT. This Note shall be binding upon the parties hereto
and their respective heirs, executors, administrators, representatives,
successors and permitted assigns.

         17. COLLECTION FEES. Except as otherwise provided herein, the Company
shall pay all costs of collection, including reasonable attorneys' fees and all
costs of suit and preparation for such suit (and whether at trial or appellate
level), in the event the unpaid principal amount of this Note, or any payment of
Interest is not paid when due, or in the event Holder is made party to any
litigation because of the existence of the Indebtedness evidenced by this Note,
or if at any time Holder should incur any attorneys' fees in any proceeding
under the Federal Bankruptcy Code (or other similar laws for the protection of
debtors generally) in order to collect any Indebtedness hereunder or to
preserve, protect or realize upon any security for, or guarantee or surety of,
such Indebtedness whether suit be brought or not, and whether through courts of
original jurisdiction, as well as in courts of appellate jurisdiction, or
through a bankruptcy court or other legal proceedings.

                                       9
<PAGE>

         18. CONSTRUCTION. This Note shall be governed as to its validity,
interpretation, construction, effect and in all other respects by and in
accordance with the laws and interpretations thereof of the State of California.
Unless the context otherwise requires, the use of terms in singular and
masculine form shall include in all instances singular and plural number and
masculine, feminine and neuter gender.

         19. SEVERABILITY. In the event any one or more of the provisions
contained in this Note or any future amendment hereto shall for any reason be
held to be invalid, illegal or unenforceable in any respect, such invalidity,
illegality or unenforceability shall not affect any other provision of this Note
or such other agreement, and in lieu of each such invalid, illegal or
unenforceable provision there shall be added automatically as a part of this
Note a provision as similar in terms to such invalid, illegal or unenforceable
provision as may be possible and be valid, legal and enforceable.

         20. ENTIRE AGREEMENT. This Note Agreement represents the entire
agreement and understanding between the parties concerning the subject matter
hereof and supersede all prior and contemporaneous agreements, understandings,
representations and warranties with respect thereto.

         21. GOVERNING LAW; JURISDICTION; JURY TRIAL. The corporate laws of the
State of Nevada shall govern all issues concerning the relative rights of the
Company and its shareholders. All other questions concerning the construction,
validity, enforcement and interpretation of this Note shall be governed by the
internal laws of the State of California, without giving effect to any choice of
law or conflict of law provision or rule (whether of the State of California or
any other jurisdictions) that would cause the application of the laws of any
jurisdictions other than the State of California. Each party hereby irrevocably
submits to the exclusive jurisdiction of the state and federal courts sitting in
the City of San Diego for the adjudication of any dispute hereunder or in
connection herewith or therewith, or with any transaction contemplated hereby or
discussed herein, or in any manner arising in connection with or related to the
transactions contemplated hereby or involving the parties hereto whether at law
or equity and under any contract, tort or any other claim whatsoever and hereby
irrevocably waives, and agrees not to assert in any suit, action or proceeding,
any claim that it is not personally subject to the jurisdiction of any such
court, that such suit, action or proceeding is brought in an inconvenient forum
or that the venue of such suit, action or proceeding is improper. Each party
hereby irrevocably waives personal service of process and consents to process
being served in any such suit, action or proceeding by mailing or faxing a copy
thereof to such party at the address for such notices as listed in this Note and
agrees that such service shall constitute good and sufficient service of process
and notice thereof. Nothing contained herein shall be deemed to limit in any way
any right to serve process in any manner permitted by law. EACH PARTY HEREBY
IRREVOCABLY WAIVES ANY RIGHT IT MAY HAVE, AND AGREES NOT TO REQUEST, A JURY
TRIAL FOR THE ADJUDICATION OF ANY DISPUTE HEREUNDER OR IN CONNECTION HEREWITH OR
ARISING OUT OF THIS NOTE OR ANY TRANSACTION CONTEMPLATED HEREBY.

                                       10
<PAGE>

         22. REPRESENTATIONS AND WARRANTIES TO SURVIVE CLOSING. All
representations, warranties and covenants contained herein shall survive the
execution and delivery of this Note and the issuance of any Conversion Shares
upon the conversion hereof.

         23. HEADINGS. The headings used in this Note are used for convenience
only and are not to be considered in construing or interpreting this Note.

         24. Definitions.

         "AFFILIATE" of any specified Person means any other Person directly or
indirectly controlling or controlled by or under direct or indirect common
control with such specified Person. For the purposes of this definition,
"control" when used with respect to any specified Person means the power to
direct the management and policies of such Person directly or indirectly,
whether through the ownership of Voting Stock, by contract or otherwise; and the
terms "controlling" and "controlled" have meanings correlative to the foregoing.

         "BOARD OF DIRECTORS" means, with respect to any Person, the Board of
Directors of such Person or any committee of the Board of Directors of such
Person duly authorized to act on behalf of the Board of Directors of such
Person.

         "CAPITAL STOCK" means, with respect to any Person, any and all shares,
interests, equity participations or other equivalents (however designated) of
corporate stock or partnership interests and any and all warrants, options and
rights with respect thereto (whether or not currently exercisable), including
each class of common stock and preferred stock of such Person.

         "GAAP" means generally accepted accounting principles as in effect in
the United States of America as of the Issue Date.

         "HOLDER" means a Person in whose name a Note is registered on the
Company's books.

         "INDEBTEDNESS" means, without duplication, with respect to any Person,
(a) all obligations of such Person (i) in respect of borrowed money (whether or
not the recourse of the lender is to the whole of the assets of such person or
only to a portion thereof); (ii) evidenced by bonds, notes, debentures or
similar instruments; (iii) representing the balance deferred and unpaid of the
purchase price of any property or services (other than accounts payable or other
obligations arising in the ordinary course of business); (iv) evidenced by
bankers' acceptances or similar instruments issued or accepted by banks, (v) for
the payment of money relating to a capitalized lease obligation under GAAP; or
(vi) evidenced by a letter of credit or a reimbursement obligation of such
Person with respect to any letter of credit; (b) all net obligations of such
Person under interest rate swap obligations and foreign currency hedges; (c) all
liabilities of others of the kind described in the preceding clauses (a) or (b)
that such Person has guaranteed or that are otherwise its legal liability; (d)
Indebtedness (as otherwise defined in this definition) of another Person secured
by lien on any asset of such Person, whether or not such Indebtedness is assumed
by such Person, the amount of such obligations being deemed to be the lesser of


                                       11
<PAGE>

(1) the full amount of such obligations so secured, and (2) the fair market
value of such asset, as determined in good faith by the Board of Directors of
such Person, which determination shall be evidenced by a board resolution; and
(e) any and all deferrals, renewals, extensions, refinancings and refundings
(whether direct or indirect) of, or amendments, modifications or supplements to,
any liability of the kind described in any of the preceding clauses (a), (b),
(c), (d) or this clause (e), whether or not between or among the same parties.

         "ISSUE DATE" means the date on which the Note is originally issued.

         "MATURITY DATE" means January 2, 2007.

         "PERSON" means any individual, corporation, partnership, joint venture,
trust, estate, unincorporated organization or government or any agency or
political subdivision thereof.

         A "SUBSIDIARY" of any Person means (i) a corporation a majority of
whose Voting Stock is at the time, directly or indirectly, owned by such Person,
by one or more subsidiaries of such Person or by such Person and one or more
subsidiaries of such Person, (ii) a partnership in which such Person or a
subsidiary of such Person is, at the date of determination, a general or limited
partner of such partnership, but only if such Person or its subsidiary is
entitled to receive more than fifty percent (50%) of the assets of such
partnership upon its dissolution, or (iii) any other Person (other than a
corporation or partnership) in which such Person, directly or indirectly, at the
date of determination thereof, has (x) at least a majority ownership interest or
(y) the power to elect or direct the election of a majority of directors or
other governing body of such Person.

         "SUBSIDIARY" means any subsidiary of the Company.

         "VOTING STOCK" means, with respect to any Person, securities of any
class or classes of Capital Stock in such Person entitling the holders thereof,
whether at all times or only so long as no senior class of stock has voting
power by reason of any contingency to vote in the election of members of the
Board of Directors or other governing body of such Person.

         25. MISCELLANEOUS. Except as otherwise provided herein, the Company
waives demand, diligence, presentment for payment and protest, notice of
extension, dishonor, maturity and protest. Time is of the essence with respect
to the performance of each and every covenant, condition, term and provision
hereof.

         IN WITNESS WHEREOF, this Note has been issued on the 2nd day of
November, 2005.

                                       AETHLON MEDICAL, INC.


                                       By ______________________________________
                                          James A. Joyce
                                          Its Chairman and CEO


                                       12
<PAGE>


Mailing Address of Holder:
ELLEN R WEINER FAMILY REVOCABLE TRUST
-------------------------------------
4004 EAST LUPINE AVENUE
------------------------------------
PHOENIX, ARIZONA  85028
------------------------------------


Mailing Address of Company:
3030 Bunker Hill Street
Suite 4000
San Diego, CA 92109


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<PAGE>

                                    EXHIBIT A

                              SCHEDULE OF ADVANCES


                        DATE                                 AMOUNT
                        ----                                 ------
                      07/11/05                              $105,000
                      08/02/05                              $ 25,000
                      08/19/05                              $ 50,000
                      08/31/05                              $100,000
                      09/14/05                              $ 75,000
                      09/30/05                              $100,000
                      10/07/05                              $ 50,000
                      10/14/05                              $ 50,000
                      10/19/05                              $ 25,000


                                       14
<PAGE>

                                    EXHIBIT B

                                CONVERSION NOTICE


                (To be signed only upon conversion of this Note)


TO:   AETHLON MEDICAL, INC.

The undersigned, the registered holder of the 10 % Series A Convertible Note
(the "Note") of AETHLON MEDICAL, INC. (the "Company"), hereby surrenders the
Note for conversion into shares of Common Stock of the Company (the "Common
Stock") to the extent of $_______ unpaid principal amount of the Note and
$_______ unpaid accrued Interest due under the Note, all in accordance with the
provisions of such Note. The undersigned requests (i) that a certificate
representing shares of Common Stock, bearing the appropriate legends, be issued
to the undersigned, and (ii) if the unpaid principal amount so converted is less
than the entire unpaid principal amount of the Note, that a new substitute note
representing the portion of said unpaid principal amount that is not so
converted be issued in accordance with the provisions of the Note.



________________________________________
(Signature and name of the registered holder)

________________________________________
Print Name

Dated:___________________________________


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