Exhibit 10.4
 AMENDMENT NUMBER 1
TO ADJUVANT LICENSE AGREEMENT
AND ADJUVANT SUPPLY AGREEMENT
 Amendment License
Agreement Supply Agreement Biomira
 WHEREAS
 AND WHEREAS
 NOW, THEREFORE
  Diligence




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Firm Forecast Forecast Date Firm Forecast
  Certain Purchase Obligations
    -2-




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Biomira Management Inc.
    
    GSK Corporation d/b/a/GlaxoSmithKline Biologicals N.A.By:
    
    /s/ Gary Christianson
    
    By:
    
    /s/ Jean StephenneName:
    
    Gary Christianson
    
    Name:
    
    Jean StephenneTitle:
    
    Chief Operating Officer
    
    Title:
    
    CEO, GSK BioDate:
    
    August 29, 2008
    
    Date:
    
    September 2, 2008
 -3-




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##### 



APPENDIX 3  Firm Forecast Mechanism (Example)
 Issued Quarterly
    
    1st year
    
    100% binding (no variation allowed)2nd year
    
    50% binding (max. 25%
increase allowed from one
revision to another one)Issued yearly in December
    
    3 > 10th year
    
    0% binding (for information only)
 2009
    
    2009
    
    
    2009
    
    
    2010
    
    
    2010
    
    
    2010
    
    
    2010
    
    
    2011
    
    
    2011
    
    
    2011
    
    
    2011
    
    
    2012
    
    
    2013
    
    
    2014
    
    
    2015
    
    
    2016
    
    
    2017
    
    
    2018Q2
    
    Q3
    
    
    Q4
    
    
    Q1
    
    
    Q2
    
    
    Q3
    
    
    Q4
    
    
    Q1
    
    
    Q2
    
    
    Q3
    
    
    Q4
    
    
    Q110g
    
    
    10g
    
    
    
    10g
    
    
    
    10g
    
    
    
    20g
    
    
    
    20g
    
    
    
    20g
    
    
    
    20g
    
    
    100g
    
    
    250g
    
    
    
    300g
    
    
    
    400g
    
    
    
    500g
    
    
    
    600g
    
    
    
    700gdone
    
    
    10g
    
    
    
    10g
    
    
    
    10g
    
    
    
    10g
    
    
    
    20g
    
    
    
    10g
    
    
    
    15g
    
    
    
    25g
    
    
    75g
    
    
    250g
    
    
    
    300g
    
    
    
    400g
    
    
    
    500g
    
    
    
    600g
    
    
    
    700gdone
    
    done
    
    
    10g
    
    
    
    10g
    
    
    
    10g
    
    
    
    25g
    
    
    
    10g
    
    
    
    18.75g
    
    
    
    25g
    
    
    
    25g
    
    
    50g
    
    
    250g
    
    
    
    300g
    
    
    
    400g
    
    
    
    500g
    
    
    
    600g
    
    
    
    700gdone
    
    done
    
    done
    
    
    10g
    
    
    
    10g
    
    
    
    25g
    
    
    
    12.5g
    
    
    
    20g
    
    
    
    25g
    
    
    
    25g
    
    
    
    25g
    
    
    
    25g
    
    
    
    250g
    
    
    
    300g
    
    
    
    400g
    
    
    
    500g
    
    
    
    600g
    
    
    
    700gdone
    
    done
    
    done
    
    done
    
    
    10g
    
    
    
    25g
    
    
    
    12.5g
    
    
    
    15g
    
    
    
    25g
    
    
    
    25g
    
    
    
    25g
    
    
    
    25g
    
    
    
    250g
    
    
    
    300g
    
    
    
    400g
    
    
    
    500g
    
    
    
    600g
    
    
    
    700g