Exhibit 10.38

Customer No. 1544

MASTER LOAN AND SECURITY AGREEMENT

THIS AGREEMENTdated as of October 23, 2000, is made by Ostex International, Inc. (the
"Borrower"), a Washington corporation having its principal place of business and chief executive office at 2203 Airport Way South, Suite 400, Seattle, WA 98134, in favor of Transamerica Business
Credit Corporation, a Delaware corporation (the "Lender"), having its principal office at Riverway II, West Office Tower, 9399 West Higgins Road, Rosemont, Illinois 60018.

WHEREAS, the Borrower has requested that the Lender make Loans to it from time to time; and

WHEREAS, the Lender has agreed to make such Loans on the terms and conditions of this Agreement.

NOW, THEREFORE, in consideration of the premises and to induce the Lender to extend credit, the Borrower hereby agrees with the Lender
as follows:



As
used herein, the following terms shall have the following meanings, and shall be equally applicable to both the singular and plural forms of the terms defined:

Agreementshall mean this Master Loan and Security Agreement together with all schedules and exhibits hereto, as amended, supplemented,
or otherwise modified from time to time.

Applicable Lawshall mean the laws of the State of Illinois (or any other jurisdiction whose laws are mandatorily applicable
notwithstanding the parties' choice of Illinois law) or the laws of the United States of America, whichever laws allow the greater interest, as such laws now exist or may be changed or amended or come
into effect in the future.

Business Dayshall mean any day other than a Saturday, Sunday, or public holiday or the equivalent for banks in New York City.

Codeshall have the meaning specified in Section 8(d).

Collateralshall have the meaning specified in Section 2.

Collateral Access Agreementshall mean any landlord waiver, mortgagee waiver, bailee letter, or similar acknowledgement of any
warehouseman or processor in possession of any Equipment.

Effective Dateshall mean the date on which all of the conditions specified in Section 3.3 shall have been satisfied.

Equipmentshall have the meaning specified in Section 2.

Event of Defaultshall mean any event specified in Section 7.

Financial Statementsshall have the meaning specified in Section 6.1.

GAAPshall mean generally accepted accounting principles in the United States of America, as in effect from time to time.

Loansshall mean the loans and financial accommodations made by the Lender to the Borrower in accordance with the terms of this
Agreement and the Notes.

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Loan Documentsshall mean, collectively, this Agreement, the Notes, and all other present and future documents, agreements,
certificates, instruments, and opinions delivered by the Borrower under, in connection with or relating to this Agreement, or any other present or future instrument or agreement between Lender and
Borrower, as each of the same may be amended, modified, extended, restated or supplemented from time to time.

Material Adverse Changeshall mean, with respect to any Person, a material adverse change in the business, prospects, operations,
results of operations, assets, liabilities, or condition (financial or otherwise) of such Person taken as a whole.

Material Adverse Effectshall mean, with respect to any Person, a material adverse effect on the business, prospects, operations,
results of operations, assets, liabilities, or condition (financial or otherwise) of such Person taken as a whole.

Noteshall mean each Promissory Note made by the Borrower in favor of the Lender, as amended, supplemented, or otherwise modified from
time to time.

Obligationsshall mean and include all loans (including the Loans), advances, debts, liabilities, obligations, covenants and duties
owing by Borrower to Lender of any kind or nature, present or future, whether or not evidenced by the Note or any note, guaranty or other instrument, whether or not arising under or in connection
with, this Agreement, any other Loan Document or any other present or future instrument or agreement, whether or not for the payment of money, whether arising by reason of an extension of credit,
opening, guaranteeing or confirming of a letter of credit, loan, guaranty, indemnification or in any other manner, whether direct or indirect (including those acquired by assignment, purchase,
discount or otherwise), whether absolute or contingent, due or to become due, now due or hereafter arising and however acquired (including without limitation all loans previously
made by Lender to Borrower). The term includes, without limitation, all interest (including interest accruing on or after a bankruptcy, whether or not an allowed claim), charges, expenses, commitment,
facility, closing and collateral management fees, letter of credit fees, reasonable attorneys' fees, taxes and any other sum properly chargeable to Borrower under this Agreement, the other Loan
Documents or any other present or future agreement between Lender and Borrower.

Permitted Liensshall mean such of the following as to which no enforcement, collection, execution, levy, or foreclosure proceeding
shall have been commenced: (a) liens for taxes, assessments, and other governmental charges or levies or the claims or demands of landlords, carriers, warehousemen, mechanics, laborers,
materialmen, and other like Persons arising by operation of law in the ordinary course of business for sums which are not yet due and payable, or liens which are being contested in good faith by
appropriate proceedings diligently conducted and with respect to which adequate reserves are maintained to the extent required by GAAP; (b) deposits or pledges to secure the payment of worker's
compensation, unemployment insurance, or other social security benefits or obligations, public or statutory obligations, surety or appeal bonds, bid or performance bonds, or other obligations of a
like nature incurred in the ordinary course of business; (c) licenses, restrictions, or covenants for or on the use of the Equipment which do not materially impair either the use of the
Equipment in the operation of the business of the Borrower or the value of the Equipment; and (d) attachment or judgment liens that do not constitute an Event of Default.

Personshall mean any individual, sole proprietorship, partnership, limited liability partnership, joint venture, trust, unincorporated
organization, association, corporation, limited liability company, institution, entity, party, or government (including any division, agency, or department thereof), and the successors, heirs, and
assigns of each.

Scheduleshall mean each Schedule in the form ofSchedule Ahereto delivered by
the Borrower to the Lender from time to time.

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Solventmeans, with respect to any Person, that as of the date as to which such Person's solvency is measured:



Taxesshall have the meaning specified in Section 5.5.

SECTION 2. CREATION OF SECURITY INTEREST; COLLATERAL.The Borrower hereby assigns and grants to the Lender a continuing
general, first priority lien on, and security interest in, all the Borrower's right, title, and interest in and to the collateral described in the next sentence (the "Collateral") to secure the
payment and performance of all the Obligations. The Collateral consists of all equipment set forth on all the Schedules delivered from time to time under the terms of this Agreement (the "Equipment"),
together with all present and future additions, parts, accessories, attachments, substitutions, repairs, improvements, and replacements thereof or thereto, and any and all proceeds thereof, including,
without limitation, proceeds of insurance and all manuals, blueprints, know-how, warranties, and records in connection therewith, all rights against suppliers, warrantors, manufacturers,
sellers, or others in connection therewith, and together with all substitutes for any of the foregoing.



SECTION 3.1. Borrowings.Each Loan shall be in an amount not less than $100,000, and in no event shall the sum of the
aggregate Loans made exceed the amount of the Lender's written commitment to the Borrower in effect from time to time. Notwithstanding anything herein to the contrary, the Lender shall be obligated to
make the initial Loan and each other Loan only after the Lender, in its sole discretion, determines that the applicable conditions for borrowing contained in Sections 3.3 and 3.4 are satisfied. The
timing and financial scope of Lender's obligation to make Loans hereunder are limited as set forth in a commitment letter executed by Lender and Borrower, dated as of October 2, 2000 and
attached hereto asExhibit A(the "Commitment Letter").

SECTION 3.2. Application of Proceeds.The Borrower shall not directly or indirectly use any proceeds of the Loans, or
cause, assist, suffer, or permit the use of any proceeds of the Loans, for any purpose other than for the purchase, acquisition, installation, or upgrading of Equipment or the reimbursement of the
Borrower for its purchase, acquisition, installation, or upgrading of Equipment.



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SECTION 3.4. Conditions Precedent to Each Loan.The obligation of the Lender to make each Loan is subject to the
satisfaction of the following conditions precedent:

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SECTION 4.1. Good Standing; Qualified to do Business.The Borrower (a) is duly organized, validly existing, and
in good standing under the laws of the State of its organization, (b) has the power and authority to own its properties and assets and to transact the businesses in which it is presently, or
proposes to be, engaged, and (c) is duly qualified and authorized to do business and is in good standing in every jurisdiction in which the failure to be so qualified could have a Material
Adverse Effect on (i) the Borrower, (ii) the Borrower's ability to perform its obligations under the Loan Documents, or (iii) the rights of the Lender hereunder.

SECTION 4.2. Due Execution, etc.The execution, delivery, and performance by the Borrower of each of the Loan Documents
to which it is a party are within the powers of the Borrower, do not contravene the organizational documents, if any, of the Borrower, and do not (a) violate any law or regulation, or any order
or decree of any court or governmental authority, (b) conflict with or result in a breach of, or constitute a default under, any material indenture, mortgage, or deed of trust or any material
lease, agreement, or other instrument binding on the Borrower or any of its properties, or (c) require the consent, authorization by, or approval of or notice to or filing or registration with
any governmental authority or other Person. This Agreement is, and each of the other Loan Documents to which the Borrower is or will be a party, when delivered hereunder or thereunder, will be, the
legal, valid, and binding obligation of the Borrower enforceable against the Borrower in accordance with its terms, except as enforceability may be limited by bankruptcy, insolvency, or similar laws
affecting creditors' rights generally and by general principles of equity.

SECTION 4.3. Solvency; No Liens.The Borrower is Solvent and will be Solvent upon the completion of all transactions
contemplated to occur hereunder (including, without limitation, the Loan to be made on the Effective Date); the security interests granted herein constitute and shall at all times constitute the first
and only liens on the Collateral other than Permitted Liens; and the Borrower is, or will be at the time additional Collateral is acquired by it, the absolute owner of the Collateral with full right
to pledge, sell, consign, transfer, and create a security interest therein, free and clear of any and all claims or liens in favor of any other Person other than Permitted Liens.

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SECTION 4.4. No Judgments, Litigation.No judgments are outstanding against the Borrower nor is there now pending or,
to the best of the Borrower's knowledge after diligent inquiry, threatened any litigation, contested claim, or governmental proceeding by or against the Borrower except judgments and pending or
threatened litigation, contested claims, and governmental proceedings which would not, in the aggregate, have a Material Adverse Effect on the Borrower.

SECTION 4.5. No Defaults.The Borrower is not in default or has not received a notice of default under any material
contract, lease, or commitment to which it is a party or by which it is bound. The Borrower knows of no dispute regarding any contract, lease, or commitment which could have a Material Adverse Effect
on the Borrower.

SECTION 4.6. Collateral Locations.On the date hereof, each item of the Collateral is located at the place of business
specified in the applicable Schedule.

SECTION 4.7. No Events of Default.No Event of Default has occurred and is continuing nor has any event occurred which,
with the giving of notice or the passage of time, or both, would constitute an Event of Default.

SECTION 4.8. No Limitation on Lender's Rights.Except as permitted herein, none of the Collateral is subject to
contractual obligations that may restrict or inhibit the Lender's rights or abilities to sell or dispose of the Collateral or any part thereof after the occurrence of an Event of Default.

SECTION 4.9. Perfection and Priority of Security Interest.This Agreement creates a valid and, upon completion of all
required filings of financing statements, perfected first priority and exclusive security interest in the Collateral, securing the payment of all the Obligations.

SECTION 4.10. Model and Serial Numbers.The Schedules set forth the true and correct model number and serial number of
each item of Equipment that constitutes Collateral.

SECTION 4.11. Accuracy and Completeness of Information.All data, reports, and information heretofore,
contemporaneously, or hereafter furnished by or on behalf of the Borrower in writing to the Lender or for purposes of or in connection with this Agreement or any other Loan Document, or any
transaction contemplated hereby or thereby, are or will be true and accurate in all material respects on the date as of which such data, reports, and information are dated or certified and not
incomplete by omitting to state any material fact necessary to make such data, reports, and information not misleading at such time. There are no facts now known to the Borrower which individually or
in the aggregate would reasonably be expected to have a Material Adverse Effect and which have not been specified herein, in the Financial Statements, or in any certificate, opinion, or other written
statement previously furnished by the Borrower to the Lender.

SECTION 4.12. Price of Equipment.The cost of each item of Equipment does not exceed the fair and usual price for such
type of equipment purchased in like quantity and reflects all discounts, rebates and allowances for the Equipment (including, without limitation, discounts for advertising, prompt payment, testing, or
other services) given to the Borrower by the manufacturer, supplier, or any other person.



SECTION 5.1. Existence, etc.The Borrower shall: (a) retain its existence and its current yearly accounting
cycle, (b) maintain in full force and effect all licenses, bonds, franchises, leases, trademarks, patents, contracts, and other rights necessary or desirable to the profitable conduct of its
business unless the failure to do so could not reasonably be expected to have a Material Adverse Effect on the Borrower, (c) continue in, and limit its operations to, the same general lines of
business as those presently conducted by it, and (d) comply with all applicable laws and regulations of any federal, state,

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or local governmental authority, except for such laws and regulations the violations of which would not, in the aggregate, have a Material Adverse Effect on the Borrower.

SECTION 5.2. Notice to the Lender.As soon as possible, and in any event within five days after the Borrower learns of
the following, the Borrower will give written notice to the Lender of (a) any proceeding instituted or threatened to be instituted by or against the Borrower in any federal, state, local, or
foreign court or before any commission or other regulatory body (federal, state, local, or foreign) involving a sum, together with the sum involved in all other similar proceedings, in excess of
$50,000 in the aggregate, (b) any contract that is terminated or amended and which has had or could reasonably be expected to have a Material Adverse Effect on the Borrower, (c) the
occurrence of any Material Adverse Change with respect to the Borrower, and (d) the occurrence of any Event of Default
or event or condition which, with notice or lapse of time or both, would constitute an Event of Default, together with a statement of the action which the Borrower has taken or proposes to take with
respect thereto.

SECTION 5.3. Maintenance of Books and Records.The Borrower will maintain books and records pertaining to the
Collateral in such detail, form, and scope as the Lender shall require in its commercially reasonable judgment. The Borrower agrees that the Lender or its agents may enter upon the Borrower's premises
at any time and from time to time during normal business hours, and at any time upon the occurrence and continuance of an Event of Default, for the purpose of inspecting the Collateral and any and all
records pertaining thereto.

SECTION 5.4. Insurance.The Borrower will maintain insurance on the Collateral under such policies of insurance, with
such insurance companies, in such amounts, and covering such risks as are at all times satisfactory to the Lender. All such policies shall be made payable to the Lender, in case of loss, under a
standard non-contributory "lender" or "secured party" clause and are to contain such other provisions as the Lender may reasonably require to protect the Lender's interests in the
Collateral and to any payments to be made under such policies. Certificates of insurance policies are to be delivered to the Lender, premium prepaid, with the loss payable endorsement in the Lender's
favor, and shall provide for not less than thirty days' prior written notice to the Lender, of any alteration or cancellation of coverage. If the Borrower fails to maintain such insurance, the Lender
may arrange for (at the Borrower's expense and without any responsibility on the Lender's part for) obtaining the insurance. Unless the Lender shall otherwise agree with the Borrower in writing, the
Lender shall have the sole right, in the name of the Lender or the Borrower, to file claims under any insurance policies, to receive and give acquittance for any payments that may be payable
thereunder, and to execute any endorsements, receipts, releases, assignments, reassignments, or other documents that may be necessary to effect the collection, compromise, or settlement of any claims
under any such insurance policies.

SECTION 5.5. Taxes.The Borrower will pay, when due, all taxes, assessments, claims, and other charges ("Taxes")
lawfully levied or assessed against the Borrower or the Collateral other than taxes that are being diligently contested in good faith by the Borrower by appropriate proceedings promptly instituted and
for which an adequate reserve is being maintained by the Borrower in accordance with GAAP. If any Taxes remain unpaid after the date fixed for the payment thereof, or if any lien shall be claimed
therefor, then, without notice to the Borrower, but on the Borrower's behalf, the Lender may pay such Taxes, and the amount thereof shall be included in the Obligations.

SECTION 5.6. Borrower to Defend Collateral Against Claims; Fees on Collateral.The Borrower will defend the Collateral
against all claims and demands of all Persons at any time claiming the same or any interest therein. The Borrower will not permit any notice creating or otherwise relating to liens on the Collateral
or any portion thereof to exist or be on file in any public office other than Permitted Liens. The Borrower shall promptly pay, when payable, all transportation, storage, and warehousing
charges and license fees, registration fees, assessments, charges, permit fees, and taxes (municipal, state, and federal) which may now or hereafter be imposed upon the ownership, leasing, renting,
possession,

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sale, or use of the Collateral, other than taxes on or measured by the Lender's income and fees, assessments, charges, and taxes which are being contested in good faith by appropriate proceedings
diligently conducted and with respect to which adequate reserves are maintained to the extent required by GAAP.

SECTION 5.7. No Change of Location, Structure, or Identity.The Borrower will not (a) change the location of its
chief executive office or establish any place of business other than those specified herein or (b) move or permit the movement of any item of Collateral from the location specified in the
applicable Schedule, except that the Borrower may change its chief executive office and keep Collateral at other locations within the United States provided that the Borrower has delivered to the
Lender (i) prior written notice thereof and (ii) duly executed financing statements and other agreements and instruments (all in form and substance satisfactory to the Lender) necessary
or, in the opinion of the Lender, desirable to perfect and maintain in favor of the Lender a first priority security interest in the Collateral. Notwithstanding anything to the contrary in the
immediately preceding sentence, the Borrower may keep any Collateral consisting of motor vehicles or rolling stock at any location in the United States provided that the Lender's security interest in
any such Collateral is conspicuously marked on the certificate of title thereof and the Borrower has complied with the provisions of Section 5.9.

SECTION 5.8. Use of Collateral; Licenses; Repair.The Collateral shall be operated by competent, qualified personnel in
connection with the Borrower's business purposes, for the purpose for which the Collateral was designed and in accordance with applicable operating instructions, laws, and government regulations, and
the Borrower shall use every reasonable precaution to prevent loss or damage to the Collateral from fire and other hazards. The Collateral shall not be used or operated for personal, family, or
household purposes. The Borrower shall procure and maintain in effect all orders, licenses, certificates, permits, approvals, and consents required by federal, state, or local laws or by any
governmental body, agency, or authority in connection with the delivery, installation, use, and operation of the Collateral. The Borrower shall keep all of the Equipment in a satisfactory state of
repair and satisfactory operating condition in accordance with industry standards, and will make all repairs and replacements when and where necessary and practical. The Borrower will not waste or
destroy the Equipment or any part thereof, and will not be negligent in the care or use thereof. The Equipment shall not be annexed or affixed to or become part of any realty without the Lender's
prior written consent.

SECTION 5.9. Further Assurances.The Borrower will, promptly upon request by the Lender, execute and deliver or use its
best efforts to obtain any document required by the Lender (including, without limitation, warehouseman or processor disclaimers, mortgagee waivers, landlord disclaimers, or
subordination agreements with respect to the Obligations and the Collateral), give any notices, execute and file any financing statements, mortgages, or other documents (all in form and substance
satisfactory to the Lender), mark any chattel paper, deliver any chattel paper or instruments to the Lender, and take any other actions that are necessary or, in the opinion of the Lender, desirable
to perfect or continue the perfection and the first priority of the Lender's security interest in the Collateral, to protect the Collateral against the rights, claims, or interests of any Persons, or
to effect the purposes of this Agreement. The Borrower hereby authorizes the Lender to file one or more financing or continuation statements, and amendments thereto, relating to all or any part of the
Collateral without the signature of the Borrower where permitted by law. A carbon, photographic, or other reproduction of this Agreement or any financing statement covering the Collateral or any part
thereof shall be sufficient as a financing statement where permitted by law. To the extent required under this Agreement, the Borrower will pay all costs incurred in connection with any of the
foregoing.

SECTION 5.10. No Disposition of Collateral.The Borrower will not in any way hypothecate or create or permit to exist
any lien, security interest, charge, or encumbrance on or other interest in any

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of the Collateral, except for the lien and security interest granted hereby and Permitted Liens which are junior to the lien and security interest of the Lender, and the Borrower will not sell,
transfer, assign, pledge, collaterally assign, exchange, or otherwise dispose of any of the Collateral. In the event the Collateral, or any part thereof, is sold, transferred, assigned, exchanged, or
otherwise disposed of in violation of these provisions, the security interest of the Lender shall continue in such Collateral or part thereof notwithstanding such sale, transfer, assignment, exchange,
or other disposition, and the Borrower will hold the proceeds thereof in a separate account for the benefit of the Lender. Following such a sale, the Borrower will transfer such proceeds to the Lender
in kind.

SECTION 5.11. No Limitation on Lender's Rights.The Borrower will not enter into any contractual obligations which may
restrict or inhibit the Lender's rights or ability to sell or otherwise dispose of the Collateral or any part thereof.

SECTION 5.12. Protection of Collateral.Upon notice to the Borrower (provided that if an Event of Default has occurred
and is continuing the Lender need not give any notice), the Lender shall have the right at any time to make any payments and do any other acts the Lender may deem necessary to protect its security
interests in the Collateral, including, without limitation, the rights to satisfy, purchase, contest, or compromise any encumbrance, charge, or lien which, in the reasonable judgment of the Lender,
appears to be prior to or superior to the security interests granted hereunder, and appear in, and defend any action or proceeding purporting to affect its security interests in, or the value of, any
of the Collateral. The Borrower hereby agrees to reimburse the Lender for all payments made and expenses incurred under this Agreement including fees, expenses, and disbursements of attorneys and
paralegals (including the allocated costs of in-house counsel) acting for the Lender, including any of the foregoing payments under, or acts taken to protect its security interests in, any
of
the Collateral, which amounts shall be secured under this Agreement, and agrees it shall be bound by any payment made or act taken by the Lender hereunder absent the Lender's gross negligence or
willful misconduct. The Lender shall have no obligation to make any of the foregoing payments or perform any of the foregoing acts.

SECTION 5.13. Delivery of Items.The Borrower will (a) promptly (but in no event later than one Business Day)
after its receipt thereof, deliver to the Lender any documents or certificates of title issued with respect to any property included in the Collateral, and any promissory notes, letters of credit or
instruments related to or otherwise in connection with any property included in the Collateral, which in any such case come into the possession of the Borrower, or shall cause the issuer thereof to
deliver any of the same directly to the Lender, in each case with any necessary endorsements in favor of the Lender and (b) deliver to the Lender as soon as available copies of any and all
press releases and other similar communications issued by the Borrower.

SECTION 5.14. Solvency.The Borrower shall be and remain Solvent at all times.

SECTION 5.15. Fundamental Changes.The Borrower shall not (a) amend or modify its name, unless the Borrower
delivers to the Lender thirty days prior to any such proposed amendment or modification written notice of such amendment or modification and within ten days before such amendment or modification
delivers executed Uniform Commercial Code financing statements (in form and substance satisfactory to the Lender) or (b) merge or consolidate with any other entity or make any material change
in its capital structure, in each case without the Lender's prior written consent which shall not be unreasonably withheld.

SECTION 5.16. Additional Requirements.The Borrower shall take all such further actions and execute all such further
documents and instruments as the Lender may reasonably request.

SECTION 6. FINANCIAL STATEMENTS.Until the payment and satisfaction in full of all Obligations, the Borrower shall
deliver to the Lender the following financial information:

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SECTION 6.1. Annual Financial Statements.As soon as available, but not later than 120 days after the end of
each fiscal year of the Borrower and its consolidated subsidiaries, the consolidated balance sheet, income statement, and statements of cash flows and shareholders equity for the Borrower and its
consolidated subsidiaries (the "Financial Statements") for such year, reported on by independent certified public accountants without an adverse qualification; and

SECTION 6.2. Quarterly Financial Statements.As soon as available, but not later than 60 days after the end of
each of the first three fiscal quarters in any fiscal year of the Borrower and its consolidated subsidiaries, the Financial Statements for such fiscal quarter, together with a certification duly
executed by a responsible officer of the Borrower that such Financial Statements have been prepared in accordance with GAAP and are fairly stated in all material respects (subject to normal
year-end audit adjustments).

SECTION 7. EVENTS OF DEFAULT.The occurrence of any of the following events shall constitute an Event of Default
hereunder:



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SECTION 8. REMEDIES.If any Event of Default shall have occurred and be continuing:



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SECTION 9.1. Notices.Except as otherwise provided herein, all notices, approvals, consents, correspondence, or other
communications required or desired to be given hereunder shall be given in writing and shall be delivered by overnight courier, hand delivery, or certified or registered mail, postage prepaid, if to
the Lender, then to Transamerica Technology Finance Division, 76 Batterson Park Road, Farmington, Connecticut 06032, Attention: Legal Department, with a copy to the Lender at Riverway II, West Office
Tower, 9399 West Higgins Road, Rosemont, Illinois 60018, Attention: Legal Department, and if to the Borrower, then to 2203 Airport Way South, Suite 400, Seattle, WA 98134, Attention: Legal Department,
or such other address as shall be designated by the Borrower or the Lender to the other party in accordance herewith. All such notices and correspondence shall be effective when received.

SECTION 9.2. Headings.The headings in this Agreement are for purposes of reference only and shall not affect the
meaning or construction of any provision of this Agreement.

SECTION 9.3. Assignments.The Borrower shall not have the right to assign any Note or this Agreement or any interest
therein unless the Lender shall have given the Borrower prior written consent and the Borrower and its assignee shall have delivered assignment documentation in form and substance satisfactory to the
Lender in its sole discretion. The Lender may assign its rights and delegate its obligations under any Note or this Agreement.

SECTION 9.4. Amendments, Waivers, and Consents.Any amendment or waiver of any provision of this Agreement and any
consent to any departure by the Borrower from any provision of this Agreement shall be effective only by a writing signed by the Lender and shall bind and benefit the Borrower and the Lender and their
respective successors and assigns, subject, in the case of the Borrower, to the first sentence of Section 9.3.

SECTION 9.5. Interpretation of Agreement.Time is of the essence in each provision of this Agreement of which time is
an element. All terms not defined herein or in a Note shall have the meaning set forth in the applicable Code, except where the context otherwise requires. To the extent a term or provision of this
Agreement conflicts with any Note, or any term or provision thereof, and is not dealt with herein with more specificity, this Agreement shall control with respect to the subject matter of such term or
provision. Acceptance of or acquiescence in a course of performance rendered under this Agreement shall not be relevant in determining the meaning of this Agreement even though the accepting or
acquiescing party had knowledge of the nature of the performance and opportunity for objection.

SECTION 9.6. Continuing Security Interest.This Agreement shall create a continuing security interest in the Collateral
and shall (i) remain in full force and effect until the indefeasible payment in full of the Obligations, (ii) be binding upon the Borrower and its successors and assigns and
(iii) inure, together with the rights and remedies of the Lender hereunder, to the benefit of the Lender and its successors, transferees, and assigns.

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SECTION 9.7. Reinstatement.To the extent permitted by law, this Agreement and the rights and powers granted to the
Lender hereunder and under the Loan Documents shall continue to be effective or be reinstated if at any time any amount received by the Lender in respect of the Obligations is rescinded or must
otherwise be restored or returned by the Lender upon the insolvency, bankruptcy, dissolution, liquidation, or reorganization of the Borrower or upon the appointment of any receiver, intervenor,
conservator, trustee, or similar official for the Borrower or any substantial part of its assets, or otherwise, all as though such payments had not been made.

SECTION 9.8. Survival of Provisions.All representations, warranties, and covenants of the Borrower contained herein
shall survive the execution and delivery of this Agreement, and shall terminate only upon the full and final payment and performance by the Borrower of the Obligations secured hereby.

SECTION 9.9. Indemnification.The Borrower agrees to indemnify and hold harmless the Lender and its directors,
officers, agents, employees, and counsel from and against any and all costs, expenses,
claims, or liability incurred by the Lender or such Person hereunder and under any other Loan Document or in connection herewith or therewith, unless such claim or liability shall be due to willful
misconduct or gross negligence on the part of the Lender or such Person.

SECTION 9.10. Counterparts; Telecopied Signatures.This Agreement may be executed in counterparts, each of which when
so executed and delivered shall be an original, but both of which shall together constitute one and the same instrument. This Agreement and each of the other Loan Documents and any notices given in
connection herewith or therewith may be executed and delivered by telecopier or other facsimile transmission all with the same force and effect as if the same was a fully executed and delivered
original manual counterpart.

SECTION 9.11. Severability.In case any provision in or obligation under this Agreement or any Note or any other Loan
Document shall be invalid, illegal, or unenforceable in any jurisdiction, the validity, legality, and enforceability of the remaining provisions or obligations, or of such provision or obligation in
any other jurisdiction, shall not in any way be affected or impaired thereby.

SECTION 9.12. Delays; Partial Exercise of Remedies.No delay or omission of the Lender to exercise any right or remedy
hereunder, whether before or after the happening of any Event of Default, shall impair any such right or shall operate as a waiver thereof or as a waiver of any such Event of Default. No single or
partial exercise by the Lender of any right or remedy shall preclude any other or further exercise thereof, or preclude any other right or remedy.

SECTION 9.13. Entire Agreement.The Borrower and the Lender agree that this Agreement, the Schedule hereto, and the
Commitment Letter are the complete and exclusive statement and agreement between the parties with respect to the subject matter hereof, superseding all proposals and prior agreements, oral or written,
and all other communications between the parties with respect to the subject matter hereof. Should there exist any inconsistency between the terms of the Commitment Letter and this Agreement, the
terms of this Agreement shall prevail.

SECTION 9.14. Setoff.In addition to and not in limitation of all rights of offset that the Lender may have under
Applicable Law, and whether or not the Lender has made any demand or the Obligations of the Borrower have matured, the Lender shall have the right to appropriate and apply to the payment of the
Obligations of the Borrower all deposits and other obligations then or thereafter owing by the Lender to or for the credit or the account of the Borrower.

SECTION 9.15. WAIVER OF JURY TRIAL.THE BORROWER AND THE LENDER IRREVOCABLY WAIVE ALL RIGHT TO TRIAL BY JURY IN ANY
ACTION, PROCEEDING, OR COUNTERCLAIM ARISING OUT OF OR RELATING TO THIS AGREEMENT, ANY

13

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OTHER LOAN DOCUMENT, OR THE TRANSACTIONS CONTEMPLATED HEREBY OR THEREBY.

SECTION 9.16. GOVERNING LAW.THE VALIDITY, INTERPRETATION, AND ENFORCEMENT OF THIS AGREEMENT SHALL BE GOVERNED BY AND
CONSTRUED IN ACCORDANCE WITH THE LAWS OF THE STATE OF ILLINOIS WITHOUT GIVING EFFECT TO THE CONFLICT OF LAW PRINCIPLES THEREOF.

SECTION 9.17. Venue; Service of Process.ANY LEGAL ACTION OR PROCEEDING WITH RESPECT TO THIS AGREEMENT OR ANY OTHER
LOAN DOCUMENT MAY BE BROUGHT IN THE COURTS OF THE STATE OF ILLINOIS SITUATED IN COOK COUNTY, OR OF THE UNITED STATES OF AMERICA FOR THE NORTHERN DISTRICT OF ILLINOIS, AND, BY EXECUTION AND DELIVERY OF
THIS AGREEMENT, THE BORROWER HEREBY ACCEPTS FOR ITSELF AND IN RESPECT OF ITS PROPERTY, GENERALLY AND UNCONDITIONALLY, THE JURISDICTION OF THE AFORESAID COURTS. THE BORROWER HEREBY IRREVOCABLY WAIVES,
IN CONNECTION WITH ANY SUCH ACTION OR PROCEEDING, (a) ANY OBJECTION, INCLUDING, WITHOUT LIMITATION, ANY OBJECTION TO THE LAYING OF VENUE OR BASED ON THE GROUNDS OF FORUM NON CONVENIENS, THAT IT
MAY NOW OR HEREAFTER HAVE TO THE BRINGING OF ANY SUCH ACTION OR PROCEEDING IN SUCH RESPECTIVE JURISDICTIONS AND (b) THE RIGHT TO INTERPOSE ANY NONCOMPULSORY SETOFF, COUNTERCLAIM, OR
CROSS-CLAIM. THE BORROWER IRREVOCABLY CONSENTS TO THE SERVICE OF PROCESS OF ANY OF THE AFOREMENTIONED COURTS IN ANY SUCH ACTION OR PROCEEDING BY THE MAILING OF COPIES THEREOF BY REGISTERED OR
CERTIFIED MAIL, POSTAGE PREPAID, TO THE BORROWER AT THE ADDRESS FOR IT SPECIFIED IN SECTION 9.1 HEREOF. NOTHING HEREIN SHALL AFFECT THE RIGHT OF THE LENDER TO SERVE PROCESS IN ANY OTHER MANNER
PERMITTED BY LAW OR TO COMMENCE LEGAL PROCEEDINGS OR OTHERWISE PROCEED AGAINST THE BORROWER IN ANY OTHER JURISDICTION, SUBJECT IN EACH INSTANCE TO THE PROVISIONS HEREOF WITH RESPECT TO RIGHTS AND
REMEDIES.

14

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IN WITNESS WHEREOF, the undersigned Borrower has caused this Agreement to be duly executed and delivered by its proper and duly
authorized officer as of the date first set forth above.

| |  | OSTEX INTERNATIONAL, INC.            
| |  | -------------------------------------
| |  | By:                                  
| |  | Name:                                
| |  | Title: Federal Tax ID No.: 91-1450247

Accepted
as of the
23rd day of October, 2000

|TRANSAMERICA BUSINESS CREDIT CORPORATION
|----------------------------------------
|By:                                     
|Name:                                   
|Title:                                  

15

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SCHEDULE A

|To: |  |  |  | Master Loan and Security Agreement |  |  |  | Collateral Access Agreement
|--- |  |  |  | ---------------------------------- |  |  |  | ---------------------------
|    |  |  |  | UCC                                |  |  |  | Opinion of Counsel         

Dated  , 200

Between

TRANSAMERICA BUSINESS CREDIT CORPORATION

and

OSTEX INTERNATIONAL, INC.

|Equipment Location: |  | 5955 Airport Way South
Seattle, Washington 98134 |  | 
|------------------- |  | ------------------------------------------------ |  | 

|QTY. |  | EQUIPMENT
DESCRIPTION |  | INVOICE
NO. |  | SUPPLIER/
VENDOR |  | SERIAL
NO. |  | PURCHASE
DATE |  | EQUIPMENT
COST |  | CHECK
NO.
|---- |  | --------------------- |  | ----------- |  | ---------------- |  | ---------- |  | ------------- |  | -------------- |  | ---------
|     |  |                       |  |             |  |                  |  |            |  |               |  |                |  |          
|     |  |                       |  |             |  |                  |  |            |  |               |  |                |  |          
|     |  |                       |  |             |  |                  |  |            |  |               |  |                |  |          
|     |  |                       |  |             |  |                  |  |            |  |               |  |                |  |          
|     |  |                       |  |             |  |                  |  |            |  |               |  |                |  |          
|     |  |                       |  |             |  |                  |  |            |  |               |  |                |  |          
|     |  |                       |  |             |  |                  |  |            |  |               |  |                |  |          
|     |  |                       |  |             |  |                  |  |            |  |               |  |                |  |          
|     |  |                       |  |             |  |                  |  |            |  |               |  |                |  |          
|     |  |                       |  |             |  |                  |  |            |  |               |  |                |  |          

|TRANSAMERICA BUSINESS CREDIT CORPORATION |  | OSTEX INTERNATIONAL, INC.
|---------------------------------------- |  | -------------------------
|By:                                      |  |                          
|Title:                                   |  |                          

---

|[LOGO]TRANSAMERICA
BUSINESS CREDIT |  | EXHIBIT A |  | Technology Finance Division
76 Batterson Paris Road
Farmington, CT 06032-2571
860 677-6466
Fax: 860 677-6766
|---------------------------------- |  | --------- |  | ------------------------------------------------------------------------------------------------------------

October 2,
2000

Mr. Tad K.
Larsen
Director of Finance
Ostex International, Inc.
2203 Airport Way South, Suite 400
Seattle, WA 98134

Dear
Tad:

Transamerica
Business Credit CorporationTechnology Finance Division ("Lender") is pleased to offer financing for the Equipment described in this letter (this
"Commitment") to Ostex International, Inc. ("Borrower"). This Commitment supersedes all prior correspondence, proposals, and oral or other communications relating to financing arrangements between
Borrower and Lender.

The
outline of this offer is as follows:

|Lender:                      |  | Transamerica Business Credit CorporationTechnology Finance Division and/or its affiliates, successors or assigns.                                                                                                                                                                              
|---------------------------- |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|Borrower:                    |  | Ostex International, Inc.                                                                                                                                                                                                                                                                       
|Amount of Loans:             |  | Not to exceed $2,800,000 in the aggregate.                                                                                                                                                                                                                                                      
|Use of Proceeds:             |  | Manufacturing ($600,000), tooling ($550,000) and leasehold improvements ($1,650,000) (the "Equipment"). All Equipment subject to Lender approval prior to funding.                                                                                                                              
|Collateral:                  |  | Lender will require a perfected first priority security interest in all Equipment financed with the Loans, including but not limited to all additions, accessions, improvements, replacements and attachments thereto and proceeds (including insurance
proceeds) thereof (the "Collateral").   
|Location of Collateral:      |  | 5955 Airport Way South, Seattle, WA                                                                                                                                                                                                                                                             
|Expected Draw-Down Schedule: |  | A minimum of $500,000 will be drawn on or before December 31, 2000, and the remaining availability will be drawn on or before December 31, 2001.                                                                                                                                                
|Draw-Down Expiration:        |  | No Equipment Loans will be funded after December 31, 2001.                                                                                                                                                                                                                                      
|Loan Term:                   |  | Each Loan Term will commence upon delivery of the equipment or upon each delivery of items of equipment having an aggregate cost of not less than $100,000 and will continue through 36 months from the first day of the month next following or
coincident with commencement of that Loan Term.
|Payment Terms:               |  | Monthly Payments equal to 3.0365% of original principal amount of each Loan will be payable monthly in advance. The first and last Monthly Payments will be due and payable on or before commencement of each Loan Term.                                                                        
|                             |  |                                                                                                                                                                                                                                                                                                 

---

|Adjustment to Payment Terms:     |  | Lender reserves the right to increase the rate set forth above as of the date each Loan Term commences commensurate to the change in the weekly average of the interest rates of 3-year U.S. Treasury Securities (as published in theWall Street Journal) from the week ending July 14, 2000 (6.34%) to the week preceding the commencement of that Loan Term. As of the date each Loan Term commences, the Monthly Payment will be fixed for that
entire Loan Term. A schedule of the actual Monthly Payments will be provided by the Lender following commencement of each Loan Term.                                                                 
|-------------------------------- |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|Balloon Payment:                 |  | At the end of each Loan Term, the Borrower will be obligated to make one final Balloon Payment equal to 15% of the original principal amount of each Loan, plus any other amounts then due and owing to Lender.                                                                                                                                                                                                                                                                                                                                                                                                                                         
|Interim Payment:                 |  | An Interim Payment will accrue from the date each Loan Term commences until the next following first day of a month (unless the Loan Term commences on the first day of a month). The Interim Payment will be calculated at the daily equivalent of the
currently adjusted Monthly Payment.                                                                                                                                                                                                                                                                                                                                                             
|Warrants:                        |  | As an inducement to the Lender to provide this Commitment, Borrower will grant to Lender Warrants to purchase 33,600 shares of the unregistered common stock of the Borrower at an exercise price equal to $3.00 per share or fair market value as of the
date of this Commitment. The Warrants will be exercisable for a period of five (5) years. The Lender will have the option to exercise the Warrants without payment of the exercise price and receive only that number of shares which represents the
value of the difference between the fair market value of the shares and the exercise price (i.e., "net issuance" or "cashless exercise").
|Insurance:                       |  | Prior to any delivery of Equipment, the Borrower will furnish confirmation of insurance acceptable to the Lender covering the Collateral including primary, all risk, physical damage, property damage and bodily injury with appropriate loss payee and
additional insured endorsements in favor of the Lender.                                                                                                                                                                                                                                                                                                                                        
|Conditions Precedent to Lending: |  | Each Loan will be subject to the following:
1.  No material adverse change in the financial condition, operations or prospects of the Borrower prior to funding. The Lender reserves the right to rescind any unused portion of its commitment in the event of a material adverse change in
the financial condition, operation or prospects of the Borrower.                                                                                                                                                                                                                                                                                            
|                                 |  | 2.  Completion of the documentation and final terms of the proposed financing satisfactory to Lender and Lender's counsel.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
|                                 |  | 3.  Results of all due diligence, including lien, judgment and tax search and other matters Lender may request shall be satisfactory to Lender and Lender's counsel.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
|                                 |  | 4.  Receipt by Lender of duly executed loan documentation in form and substance satisfactory to Lender and its counsel.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
|                                 |  |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         

2

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|                      |  | 5.  Lender shall receive a valid and perfected first priority lien and security interest in the Collateral and Lender shall have received satisfactory evidence that there are no liens on the Collateral except as expressly permitted
herein.                                                                                                                                                                                                               
|--------------------- |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|Additional Covenants: |  | There will be no actual or threatened conflict with, or violation of, any regulatory statute, standard or rule relating to the Borrower, its present or future operations, or the Collateral.                                                                                                                                                                                                                                                                 
|                      |  | Borrower will be required to provide quarterly financial information. All information supplied by the Borrower will be correct and will not omit any statement necessary to make the information supplied not be misleading. There will be no material
breach of the representations and warranties of the Borrower in the loan.                                                                                                                              
|Expenses:             |  | All costs and expenses incurred by the Lender in connection with the underwriting and closing of the Loans will be paid by the Borrower whether or not any Loans are consummated and funds are advanced by the Lender. Expenses shall not exceed $5,000
without the prior consent of the Borrower.                                                                                                                                                            
|Law:                  |  | This letter and the proposed Loan are intended to be governed by and construed in accordance with Illinois law without regard to its conflict of law provisions.                                                                                                                                                                                                                                                                                              
|Indemnity:            |  | Borrower agrees to indemnify and to hold harmless Lender, and its officers, directors and employees against all claims, damages, liabilities and expenses which may be incurred by or asserted against any such person in connection with or arising out
of this letter and the transactions contemplated hereby, other than claims, damages, liability, and expense resulting from such person's gross negligence or willful misconduct.                     
|Confidentiality:      |  | This letter is delivered to you with the understanding that neither it nor its substance shall be disclosed publicly or privately to any third person except those who are in a confidential relationship to you (such as your legal counsel and
accountants), or where the same is required by law and then only on the basis that it not be further disclosed, which conditions Borrower and its agents agree to be bound by upon acceptance of this letter.
|                      |  | Without limiting the generality of the foregoing, none of such persons shall use or refer to Lender or to any affiliate name in any disclosures made in connection with any of the transactions without Lender's prior written consent.                                                                                                                                                                                                                       
|                      |  | Upon completion of the initial takedown by Borrower, the Borrower will no longer be required to obtain Lender's prior written consent to disclose the transaction contemplated hereby. In addition, the Borrower agrees to provide camera ready artwork of
typestyles and logos of the Borrower for use in promotional material by the Lender.                                                                                                                
|                      |  |                                                                                                                                                                                                                                                                                                                                                                                                                                                               

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|Conditions of Acceptance: |  | This Commitment Letter is intended to be a summary of the most important elements of the agreement to enter into a loan transaction with Borrower, and it is subject to all requirements and conditions contained in Loan documentation proposed by Lender
or its counsel in the course of closing the Loans described herein. Not every provision that imposes duties, obligations, burdens, or limitations on Borrower is contained herein, but shall be contained in the final Loan documentation satisfactory to
Lender and its counsel.
|------------------------- |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|                          |  | EACH OF THE PARTIES HERETO IRREVOCABLY AND UNCONDITIONALLY WAIVES ALL RIGHT TO TRIAL BY JURY IN ANY SUIT, ACTION, PROCEEDING OR COUNTERCLAIM ARISING OUT OF OR RELATED TO THIS LETTER OR THE TRANSACTION DESCRIBED IN THIS LETTER.                                                                                                                                                                                                                                                                                                          
|Application Fee:          |  | The $14,000 Application Fee previously paid by the Borrower will be applied to the Commitment Fee.                                                                                                                                                                                                                                                                                                                                                                                                                                          
|Commitment Fee:           |  | A non-refundable Commitment Fee equal to 1% ($28,000) of the maximum amount of the Commitment shall be due the Lender upon acceptance of the Commitment. The Commitment Fee, after being applied to costs and expenses of the Lender in closing the Loan,
shall be applied proportionately to the first payment of each draw-down under the Loan.                                                                                                                                                                                           
|Commitment Expiration:    |  | This Commitment shall expire on October 9, 2000 unless prior thereto either extended in writing by the Lender or accepted as provided below by the Borrower.                                                                                                                                                                                                                                                                                                                                                                                

Should
you have any questions, please call me. If you wish to accept this Commitment, please so indicate by signing and returning the enclosed duplicate copy of this letter to me by
October 9, 2000.

| |  | Yours truly,                                                 
| |  | -------------------------------------------------------------
| |  | TRANSAMERICA BUSINESS CREDIT CORPTECHNOLOGY FINANCE DIVISION
| |  | By:                                                          

|Accepted this 3rd day of October, 2000.
|---------------------------------------
|OSTEX INTERNATIONAL, INC.              
|By:                                    
|Name: Thomas A. Bologna                
|Title:Chairman, President & CEO        

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