Exhibit 10.3
 FOURTH AND VINE
OFFICE LEASE
  DESCRIPTION
     TERM
 RENT
 12/18/11  12/17/12
    
    $
    31.5012/18/12  12/17/13
    
    $
    32.0012/18/13
 12/17/14
    
    $
    32.5012/18/14  12/17/15
    
    $
    33.0012/18/15  12/17/16
    
    $
    33.5012/18/16  12/17/17
    
    $
    34.0012/18/17  12/17/18
    
    $
    34.50
  CONSIDERATION




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USES
 RULES AND REGULATIONS
 CARE AND SURRENDER OF PREMISES
 ALTERATIONS
 -2-




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RESTRICTIONS
 WEIGHT RESTRICTIONS
 SIGN RESTRICTION
 LOCKS
 KEY
 -3-




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TELEPHONE SERVICE
 SERVICES
   -4-




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SOLICITORS
 FLOOR PLAN
 ASSIGNMENT
 OPERATING SERVICES AND REAL ESTATE TAXES
  Base Year
 -5-




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Comparison Year
  Operating Services
         -6-




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-7-




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Real Estate Taxes
  Proportionate Basis
  Computation of Adjustments to Base Year Costs
  -8-




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ADDITIONAL TAXES OR ASSESSMENTS
 LATE PAYMENTS
  RISK
 INDEMNIFICATION
 -9-




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WAIVER OF SUBROGATION
 SUBORDINATION
 CASUALTY
 -10-




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INSOLVENCY
 DEFAULT
 -11-




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EXCESS UTILITIES AND SERVICES/ACTUAL COSTS
 TENANT IMPROVEMENT ALLOWANCE
 -12-




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SPACE PLANNING ALLOWANCE
 RENEWAL OPTION
   -13-




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TERMINATION OPTION
 EXPANSION RIGHTS
  PARKING
 -14-




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BINDING EFFECT
  HOLDING OVER
 ATTORNEYS FEES
 NO REPRESENTATIONS
 QUIET ENJOYMENT
 RECORDATION
 MUTUAL PREPARATION OF LEASE
 GOVERNING LAW
 NOTICES
 -15-




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ENVIRONMENTAL
 APPROVALS
 REASONABLE EXPENDITURES
 LESSORS DEFAULT
 PRIOR SUBLEASE
 -16-




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BROKER COMMISSION
 SELIG HOLDINGS COMPANY,
    
    ONCOTHYREON INC.,a Washington limited liability company
    
    a Delaware corporation/s/ Martin Selig
    
    /s/ Robert Kirkman, M.D.By: Martin Selig
    
    By: Robert Kirkman, M.D.Its: Managing Member
    
    Its: CEOLessor
    
    Lessee
 -17-




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STATE OF WASHINGTON
    
    
    ))
    
    
    ss.COUNTY OF KING
    
    
    )
 th
 /s/ Jill M. HayesNotary Public in and for the State of WashingtonResiding at: Issaquah
My commission expires: June 1, 2010 (Individual)STATE OF
    
    
    ))
    
    
    ss.COUNTY OF
    
    
    )
 
 Notary Public in and for the State ofResiding at:My commission expires:




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(Partnership)STATE OF
    
    
    ))
    
    
    ss.COUNTY OF
    
    
    )
 
 Notary Public in and for the State ofResiding at:My commission expires:
 (Corporation)STATE OF WASHINGTON
    
    
    ))
    
    
    ss.COUNTY OF KING
    
    
    )
 th
 /s/ Marcia K. NewlunNotary Public in and for the State of WashingtonResiding at: Redmond
My commission expires: March 9, 2009 -2-




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Exhibit A




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Exhibit B
 EXAMPLE
      HYPOTHETICAL FACTS
 Building Occupancy:
    
    
    80%Actual Base Year Costs:
    
    
    $375,000Grossed Base Year Costs to 95%:
    
    
    $440,000Actual Comparison Year Costs: (see below)
    
    
    $405,440Grossed Comparison Year Costs to 95%: (see below)
    
    
    $463,080Tenant Premises:
    
    
    10,000 RSFBuilding RSF:
    
    
    125,000 RSFTenant Proportionate Basis:
    
    
    10,000 + 125,000 8
    %




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EXAMPLE
 Actual
    
    
    GrossedDescription
    
    Expenses
    
    
    ExpensesPercent Occupied
    
    
    80.00
    %
    
    
    95.00
    %
    
    MethodologyReal Estate Taxes
    
    $
    54,854
    
    
    $
    54,854
    
    
    Actual CostOperating ExpensesInsurance
    
    $
    26,595
    
    
    $
    26,595
    
    
    Actual CostElectricity
    
    $
    69,358
    
    
    $
    82,363
    
    
    Adjusts with occupancyWater & Sewer
    
    $
    4,945
    
    
    $
    5,872
    
    
    Adjusts with occupancySecurity
    
    $
    5,000
    
    
    $
    5,000
    
    
    Actual CostElevator
    
    $
    7,526
    
    
    $
    7,526
    
    
    Actual CostSuperintendent
    
    $
    82,869
    
    
    $
    98,407
    
    
    Adjusts with occupancyLandscaping
    
    $
    2,912
    
    
    $
    2,912
    
    
    Actual CostDisposal
    
    $
    15,502
    
    
    $
    18,409
    
    
    Adjusts with occupancyManagement
    
    $
    41,680
    
    
    $
    49,495
    
    
    Adjusts with occupancySupplies
    
    $
    4,339
    
    
    $
    5,153
    
    
    Adjusts with occupancyWindow Washing
    
    $
    1,527
    
    
    $
    1,813
    
    
    Adjusts with occupancyRepairs & Maintenance
    
    $
    24,333
    
    
    $
    28,895
    
    
    Adjusts with occupancyTelephone
    
    $
    1,144
    
    
    $
    1,144
    
    
    Actual CostHVAC Maintenance
    
    $
    6,208
    
    
    $
    7,372
    
    
    Adjusts with occupancyJanitorial
    
    $
    56,648
    
    
    $
    67,270
    
    
    Adjusts with occupancyTOTALS:
    
    $
    405,440
    
    
    $
    463,080
 -2-




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Exhibit C
 WORK LETTER




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Schedule 1 to Work Letter
Description of Tenant Improvements