Sales Agreement



 Exhibit 10.1 

CARDIUM THERAPEUTICS, INC. 

DOCS®
 financing facility 
 Shares of Common Stock, 

$0.0001 par value 

SALES AGREEMENT 

September 28, 2010 







 THIS SALES AGREEMENT (the “Agreement”) dated as of
September 28, 2010 is made and entered into by and between Brinson Patrick Securities Corporation, having its principal office at 1515 Broadway,
11th Floor, New York, New York 10036 (the “Sales
Manager”) and Cardium Therapeutics, Inc., a corporation organized and existing under the laws of the State of Delaware (the “Company”). 

WHEREAS, the Company desires to issue and sell through the Sales Manager, as agent, shares of its Common Stock, $0.0001 par value (the
“Stock”), on the terms set forth in Article II below. 
 IN CONSIDERATION of the mutual covenants contained in this
Agreement, the Company and the Sales Manager agree as follows: 
 ARTICLE I 

REPRESENTATIONS AND WARRANTIES 

OF THE COMPANY 

1.1 For purposes of this Agreement, unless the context requires to the contrary, the term “Company” shall also include all
significant subsidiaries (as defined by Section 1-02 of Regulation S-X) of the Company. The Company represents and warrants to, and agrees with, the Sales Manager that: 

(a) The Company meets the requirements for use of Form S-3 under the Securities Act of 1933, as amended (the “Act”), and the
rules and regulations thereunder (“Rules and Regulations”), and the Company is eligible to use Form S-3 for the transactions contemplated by this Agreement. A registration statement on Form S-3 (Registration No. 333-168693) with
respect to, among other securities, the Stock, including a form of prospectus, has been prepared by the Company in conformity with the requirements of the Act and the Rules and Regulations, has been filed with the Securities and Exchange Commission
(the “Commission”) and has been declared effective by the Commission. No stop order suspending the effectiveness of such registration statement has been issued, and no proceeding for that purpose has been instituted or, to the knowledge of
the Company, threatened by the Commission. Such registration statement, as it may have heretofore been or may hereafter be amended, is referred to herein as the “Registration Statement,” and the final form of prospectus included in the
Registration Statement for purposes of offers and sales of the Stock contemplated herein, as amended or supplemented from time to time, is referred to herein as the “Prospectus.” Any reference herein to the Registration Statement, the
Prospectus, or any amendment or supplement thereto shall be deemed to refer to and include the documents incorporated (or deemed to be incorporated) by reference therein, and any reference herein to the terms “amend,” “amendment”
or “supplement” with respect to the Registration Statement or Prospectus shall be deemed to refer to and include the filing after the execution hereof of any document with the Commission deemed to be incorporated by reference therein.

 (b) Each part of the Registration Statement, when such part became or becomes effective, and the Prospectus and any amendment
or supplement thereto, on the date of filing thereof with the Commission and at each Settlement Date (as hereinafter defined), conformed or will conform in all material respects with the requirements of the Act and the Rules and Regulations; each
part of the Registration Statement, when such part became or becomes effective, did not or will not contain an untrue statement of a material fact or omit to state a material fact required to be stated therein or necessary to make the statements
therein not misleading; and the Prospectus and any amendment or supplement thereto, on the date of filing thereof with the Commission and at each Settlement Date, did not or will not include an untrue statement of a material fact or omit to state a
material fact necessary to make the statements therein, in the light of the circumstances under which they were made, not misleading; except that the foregoing shall not apply to statements in or omissions from any such document in reliance upon,
and in conformity with, written information furnished to the Company by or on behalf of the Sales Manager, specifically for use in the Registration Statement, the Prospectus or any amendment or supplement thereto. There are no Commission comments to
any part of the Registration Statement, Prospectus or any amendment or supplement thereto, that have not been resolved as of the date hereof. 
  

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 (c) The documents incorporated by reference in the Registration Statement or the Prospectus,
or any amendment or supplement thereto, when they were or are filed with the Commission under the Securities Exchange Act of 1934, as amended (the “Exchange Act”), conformed or will conform in all material respects with the requirements of
the Act or the Exchange Act, as applicable, and the rules and regulations of the Commission thereunder. 
 (d) The financial
statements of the Company, together with the related schedules and notes thereto, set forth or included in the Registration Statement and Prospectus, fairly present the financial condition of the Company as of the dates indicated and the results of
operations, changes in financial position, stockholders’ equity, and cash flows for the periods therein specified, in conformity with United States generally accepted accounting principles consistently applied throughout the periods involved
(except as otherwise stated therein). The summary and selected financial and statistical data, if any, included in the Registration Statement and the Prospectus present fairly the information shown therein and, to the extent based upon or derived
from the financial statements, have been compiled on a basis consistent with the financial statements presented therein. As of the date hereof, there are no comments pending from the Commission that, if not resolved favourably to the Company, could
have the effect of requiring a restatement of financial statements of the Company. 
 (e) The accountants who certified the
financial statements and the supporting schedules included in the Registration Statement are and, during the periods covered by their reports, were qualified and independent public accountants as required by Rule 2-01 of Regulation S-X and by the
rules of the Public Company Accounting Oversight Board. 
 (f) The Company has been duly organized and is validly existing as a
corporation in good standing under the laws of the State of Delaware. The Company is duly qualified and in good standing as a foreign corporation in each jurisdiction in which the character or location of its assets or properties (owned, leased or
licensed) or the nature of its business makes such qualification necessary (including every jurisdiction in which it owns or leases real property), except for such jurisdictions where the failure to so qualify would not have a Material Adverse
Effect on the Company. For purposes of this Agreement, “Material Adverse Effect” means (i) any adverse effect on the assets or properties, business, results of operations, financial condition of the Company that is material to the
Company, and/or (ii) any material adverse effect on the transactions contemplated under this Agreement or any other agreement or document contemplated hereby or thereby. Each of the Company’s significant subsidiaries is validly existing
and in good standing as a corporation, limited liability company or partnership, as applicable, in its respective jurisdiction of formation. Schedule 1.1(f) hereto identifies each of the Company’s subsidiaries that is a significant subsidiary
(as defined in Section 1-02 of Regulation S-X) of the Company. Except as otherwise disclosed in the Registration Statement and the Prospectus, all of the issued and outstanding capital stock, limited liability company interests or partnership
interests, as applicable, of each significant subsidiary has been duly authorized and validly issued, is fully paid and nonassessable and is owned by the Company, directly or indirectly, free and clear of any security interest, mortgage, pledge,
lien, encumbrance, claim or equity. The Company has all requisite corporate power and authority and all necessary authorizations, approvals, consents, orders, licenses, certificates and permits of and from all governmental orders or regulatory
bodies or any other person or entity, to own, lease, license and operate its assets and properties and conduct its business as now being conducted and as described in the Registration Statement and the Prospectus; except for such authorizations,
approvals, consents, orders, licenses, certificates and permits the absence of which would not have a Material Adverse Effect. 
  

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 (g) The Company has good and marketable title to, or leasehold interests in, all properties
and assets as described in the Registration Statement and the Prospectus as owned by the Company, free and clear of all liens, charges, encumbrances or restrictions, except such as are described in the Registration Statement and the Prospectus and
except such as would not have a Material Adverse Effect on the Company. 
 (h) The Company has been subject to the requirements
of Section 12 of the Exchange Act during the period commencing 12 months preceding the filing of the Registration Statement and ending on the date hereof (the “Reporting Period”) and during such Reporting Period the Company has timely
filed all material and reports required under Sections 13(a), 14 and/or 15(d) of the Exchange Act, except that the pro forma financial statements for the disposition of assets reported in the Company’s current report on Form 8-K filed
July 29, 2009 were filed by amendment on Form 8-K/A on August 25, 2009. All such materials and reports conformed in form and substance to the requirements of the Exchange Act and the rules and regulations thereunder. As of the date hereof,
either (A) the aggregate market value of all securities sold by or on behalf of the Company pursuant to General Instruction I.B.6. of Form S-3 under the Act during the period of twelve calendar months immediately prior to, and including, the
date hereof (including without limitation any Stock sold prior to the date hereof or to be sold on the date hereof pursuant to this Agreement, if applicable), in each case calculated in accordance with Instruction 2 to General Instruction I.B.6. of
Form S-3, is not more than one-third of the aggregate market value of the voting and non-voting “common equity” (as such term is defined in Rule 405 under the Act) held by non-affiliates of the Company calculated in accordance with
Instruction 1 to General Instruction I.B.6. of Form S-3 (the “Public Float”) or (B) the Public Float is at least $75 million. The Company is not, and has not previously been in the last 12 months, a “shell company” (as such
term is defined in Rule 405 under the Act). 
 (i) There is no litigation or governmental or other proceeding or investigation
before any court or before or by any public body or board pending or, to the knowledge of the Company, threatened against, or involving the assets, properties or businesses of the Company which, if resolved against the Company, would have a Material
Adverse Effect on the Company or the offering contemplated by this Agreement, except as described in the Registration Statement. 
  

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 (j) The Company maintains insurance (issued by insurers of recognized financial
responsibility) of the types and in the amounts generally deemed adequate for its businesses and, to the knowledge of the Company, consistent with insurance coverage maintained by similar companies in similar businesses, including, but not limited
to, product liability insurance covering the Company’s products, insurance covering real and personal property owned or leased by the Company against theft, damage, destruction, acts of vandalism and all other risks customarily insured against,
all of which insurance is in full force and effect. 
 (k) Subsequent to the respective dates as of which information is given
in the Registration Statement and the Prospectus, except as described therein, (i) there has not been any material adverse change in the assets or properties, business, results of operations, or financial condition of the Company, whether or
not arising from transactions in the ordinary course of business; (ii) the Company has not sustained any material loss or interference with its assets, businesses or properties (whether owned or leased) from fire, explosion, earthquake, flood
or other calamity, whether or not covered by insurance, or from any labor dispute or any court or legislative or other governmental action, order or decree; (iii) the Company has not undertaken any liability or obligation, direct or contingent,
except such liabilities or obligations undertaken in the ordinary course of business; and (iv) there has not been any transaction that is material to the Company, except transactions in the ordinary course of business or as otherwise disclosed
in the Registration Statement and the Prospectus. 
 (l) There is no document or contract of a character required to be
described in the Registration Statement or the Prospectus or to be filed as an exhibit to the Registration Statement that is not described or filed in the manner and within the time periods required under the Exchange Act. Each document, instrument,
contract and agreement of the Company described in the Registration Statement or the Prospectus or incorporated by reference therein or listed as exhibits to the Registration Statement is in full force and effect and is valid and enforceable by and
against the Company in accordance with their terms, assuming the due authorization, execution and delivery thereof by each of the other parties thereto, except as otherwise disclosed in the Registration Statement or Prospectus. The Company is not,
nor to the knowledge of the Company is any other party, in default in the observance or performance of any term or obligation to be performed by it under any such agreement, and no event has occurred which with notice or lapse of time or both would
constitute such a default, which default or event would have a Material Adverse Effect. No default exists, and no event has occurred which with notice or lapse of time or both would constitute a default, in the due performance and observance of any
term, covenant or condition, by the Company of any other agreement or instrument to which the Company is a party or by which it or its properties or business may be bound or affected, which default or event would have a Material Adverse Effect.

 (m) The Company is not in violation of any term or provision of its charter, by-laws or operating agreement, as applicable.
The Company is not in violation of any franchise, license, permit, judgment, decree, order, statute, rule or regulation, where the consequences of such violation would have a Material Adverse Effect. The Company’s common stock is duly listed
and registered on the Trading Market (as defined below) and the Company is not in breach or violation of, or in default under, any of the rules and regulations of the Trading Market. The Company has not received any notice from the Trading Market
regarding the delisting or the potential delisting of the Company’s common stock from the Trading Market except as disclosed in the Registration Statement. 
  


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 (n) Except as described in the Prospectus, neither the execution, delivery and performance
of this Agreement by the Company nor the consummation of any of the transactions contemplated hereby (including, without limitation, the issuance and sale by the Company of the Stock) will give rise to a right to terminate or accelerate the due date
of any payment due under, or conflict with or result in the breach of any term or provision of, or constitute a default (or an event which with notice or lapse of time or both would constitute a default) under, or require any consent or waiver
under, or result in the execution or imposition of any lien, charge, encumbrance, claim, security interest, restriction or defect upon any properties or assets of the Company pursuant to the terms of, any indenture, mortgage, deed of trust or other
agreement or instrument to which the Company is a party or by which the Company is bound, or any of its properties are bound, or any franchise, license, permit, judgment, decree, order, statute, rule or regulation applicable to the Company or
violate any provision of the charter or by-laws of the Company, except for such consents or waivers which have already been obtained and are in full force and effect. 

(o) All of the outstanding shares of common stock of the Company have been duly authorized and validly issued and are fully paid and
nonassessable and none of such shares were issued in violation of any pre-emptive or other similar right. The Stock, when issued and sold pursuant to this Agreement, will be duly authorized and validly issued, fully paid and nonassessable and will
not be issued in violation of any pre-emptive or other similar right. Except as disclosed in the Registration Statement and the Prospectus, there is no outstanding option, warrant or other right calling for the issuance of, and there is no
commitment or arrangement to issue, any capital stock of the Company or any security convertible into or exercisable or exchangeable for such capital stock, except for standard dividend reinvestment plans. The Stock conforms in all material respects
to all statements relating thereto contained in the Registration Statement and the Prospectus. All stock options issued by the Company have been issued in compliance with law; and the terms and provision of such stock options were established in
compliance with law. 
 (p) Subsequent to the respective dates as of which information is given in the Registration Statement
and the Prospectus, except as (x) described or referred to therein, or (y) are not material (as to clauses (i) and (ii) only), are consistent with past practice (as to clauses (i) and (ii) only), and are publicly
disclosed, the Company has not (i) issued any securities (except as would have been permitted pursuant to the proviso contained in Section 3.1(k) of this Agreement) or incurred any liability or obligation, direct or contingent, except such
liabilities or obligations incurred in the ordinary course of business including, without limitation, debt financing to acquire and develop properties, (ii) entered into any transaction not in the ordinary course of business or
(iii) declared or paid any dividend or made any distribution on any shares of its capital stock or redeemed, purchased or otherwise acquired or agreed to redeem, purchase or otherwise acquire any shares of its capital stock. 

 

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 (q) Except as disclosed in the Registration Statement and Prospectus, no holder of any
security of the Company has the right, which has not been waived, to have any security owned by such holder included in the Registration Statement. 

(r) All necessary corporate action has been duly and validly taken by the Company to authorize the execution, delivery and performance of
this Agreement and the issuance and sale of the Stock by the Company. This Agreement has been duly and validly authorized, executed and delivered by the Company and constitutes and will constitute the legal, valid and binding obligation of the
Company, enforceable against the Company in accordance with its terms, except insofar as enforceability may be limited by (i) applicable bankruptcy, insolvency, reorganization, moratorium or other similar laws affecting the rights of creditors
generally or (ii) principles or rules of law governing specific performance, injunctive relief or the availability of other equitable remedies. Except for any “blue sky” filings or Trading Market (as defined below) listing
applications to be filed pursuant hereto), each approval, consent, order, authorization, designation, declaration or filing by or with any regulatory, administrative or other governmental body necessary in connection with the execution and delivery
by the Company of this Agreement and the consummation of the transactions contemplated hereby and the issuance and sale of the Stock by the Company has been obtained or made and is in full force and effect. The Company will use commercially
reasonable efforts to cause the Stock to be listed for trading on the Trading Market. For purposes of this Agreement, the “Trading Market” is (i) the NYSE Amex, and (ii) each other national securities exchange or market on which
the common stock of the Company trades or is admitted for trading. 
 (s) The Company has not incurred any liability for a fee,
commission or other compensation on account of the employment of a broker or finder in connection with the transactions contemplated by this Agreement other than as contemplated hereby or as described in the Registration Statement. 

(t) The Company is conducting its business in compliance with all applicable laws, rules and regulations of the jurisdictions in which it
is conducting business, except where the failure to be so in compliance would not have a Material Adverse Effect. 
 (u) No
transaction has occurred between or among the Company and any of its officers or directors or any affiliate or affiliates of any such officer or director that is required to be described in and is not described in the Registration Statement and the
Prospectus. 
 (v) The Company has not taken, nor will it take, directly or indirectly, any action designed to or which might
reasonably be expected to cause or result in, or which has constituted or which might reasonably be expected to constitute, the stabilization or manipulation of the price of the common stock of the Company to facilitate the sale or resale of any of
the Stock. 
 (w) The Company has filed all federal, state, local and foreign tax returns that are required to be filed through
the date hereof (and will file all such tax returns when and as required to be filed after the date hereof), or has received extensions thereof, and has paid all taxes shown on such returns to be due on or prior to the date hereof (and will pay all
taxes shown on such returns to be due after the date hereof) and all assessments received by it to the extent that the same are material and have become due except where the failure to file such a return or pay such amount would not have a Material
Adverse Effect. 
  

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 (x) The Company owns or has valid, binding and enforceable licenses or other rights to use
the patents and patent applications, inventions, copyrights, trademarks, service marks, trade names, service names, technology and know-how (including without limitation trade secrets and other unpatented and/or unpatentable proprietary rights but
excluding generally commercially available “off the shelf” software programs licensed pursuant to shrink wrap or “click and accept” licenses) necessary to conduct the business of the Company in the manner described in the
Registration Statement and the Prospectus (collectively, the “Company Intellectual Property”), except for any Company Intellectual Property the absence of which, individually or in the aggregate, would not have a Material Adverse Effect.
Except as described in the Prospectus, the Company Intellectual Property is free and clear of any pledge, lien, security interest, encumbrance, claim or equitable interest, whether imposed by agreement, contract, understanding, law, equity or
otherwise, except for (i) liens for taxes not yet due, (ii) mechanics liens and similar liens for labor, materials or supplies incurred in the ordinary course of business for amounts that are not delinquent and (iii) any liens that
individually or in the aggregate are not material (a “Permitted Liens”) or where any failure to have such adequate licenses or other rights of use to such Intellectual Property, individually or in the aggregate, would not reasonably be
expected to have, individually or in the aggregate, a Material Adverse Effect. The Company is not obligated to pay a royalty, grant a license or provide other consideration to any third party in connection with the Company Intellectual Property
other than as disclosed in the Registration Statement and the Prospectus. Except as disclosed in the Registration Statement and the Prospectus or as would not have a Material Adverse Effect, (i) the Company has not received any notice of
infringement or conflict with asserted rights of others with respect to any Company Intellectual Property, (ii) the conduct of the business of the Company in the manner described in the Registration Statement and the Prospectus does not and, to
the knowledge of the Company, will not, infringe, interfere or conflict with any valid issued patent claim or other Intellectual Property right of any third party and (iii) no third party, including without limitation any academic or
governmental organization, possesses or could obtain rights to the Company Intellectual Property which, if exercised, could enable such party to develop products competitive to those of the Company, other than rights arising under applicable law in
connection with government sponsorship of Company research activities. Except as disclosed in the Registration Statement and the Prospectus, the Company has not received any notice or has any knowledge of (i) any potential infringement or
misappropriation by others of the Company Intellectual Property or (ii) any Intellectual Property of others that potentially conflicts or interferes with the Company Intellectual Property, that might reasonably be expected to have, individually
or in the aggregate, a Material Adverse Effect. To the Company’s knowledge, no claim of any patent or patent application (assuming the claims of patent applications issue as currently pending) included in the Company Intellectual Property is
unenforceable or invalid, except for such unenforceability or invalidity that would not reasonably be expected to result, individually or in the aggregate, in a Material Adverse Effect. Each former and current key employee and key independent
contractor of the Company has signed and delivered one or more written contracts with the Company pursuant to which such employee or independent contractor assigns to the Company all of his, her or its rights in and to any inventions, discoveries,
improvements, works of authorship, know-how or information made, conceived, reduced to practice, authored or discovered in the course of employment by or performance of services for the Company and any and all patent rights, copyrights, trademark
and other intellectual property rights therein or thereto. 
  

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 (y) Except as described in the Registration Statement and the Prospectus, the Company
possesses all certificates, authorizations and permits issued by the appropriate federal, state or foreign regulatory authorities necessary to conduct their respective businesses as currently conducted, including without limitation all such
certificates, authorizations and permits required by the United States Food and Drug Administration (the “FDA”) or any other federal, state or foreign agencies or bodies engaged in the regulation of medical devices, pharmaceuticals or
biohazardous materials, except where the failure to so possess such certificates, authorizations and permits, individually or in the aggregate, would not result in a Material Adverse Effect. Except as described in the Registration Statement and the
Prospectus, the Company has not received any notice of proceedings relating to the revocation or modification of any such certificate, authorization or permit which, individually or in the aggregate, if the subject of an unfavorable decision, ruling
or finding, would have a Material Adverse Effect. 
 (z) Except as described in the Registration Statement and the Prospectus,
the Company and the Subsidiaries and, to the Company’s knowledge, any third party manufacturer of Company products are, and at all times have been, in material compliance with all regulatory requirements applicable to the business, including
the registration and listing requirements set forth in 21 C.F.R. part 807. Except as described in the Registration Statement and the Prospectus, the Company and the Subsidiaries are, and at all times have been, in compliance with the written
procedures, record-keeping, and FDA reporting requirements for Medical Device Reporting set forth in 21 C.F.R. part 803 and similar adverse event reporting requirements outside of the United States. 

(aa) Except to the extent disclosed in the Registration Statement and the Prospectus, the Company has not received any written notices or
statements from the FDA, the European Medicines Agency (“EMEA”) or any other governmental agency, and otherwise has no knowledge or reason to believe, that (i) any marketing authorization application for any medical device, drug
candidate or combination therapy of the Company described in the Registration Statement or Prospectus (each a “Potential Product”) may or will be rejected or determined to be non-approvable; (ii) a delay in time for review and/or
approval of a marketing authorization application or marketing approval application in any jurisdiction for Potential Product is or may be required, requested or being implemented; (iii) one or more clinical studies for Potential Product shall
or may be requested or required in addition to the clinical studies submitted to the FDA prior to the date hereof as a precondition to or condition of issuance or maintenance of a marketing approval for Potential Product; (iv) any license,
approval, permit or authorization to conduct any clinical trial of or market any product or potential product of the Company has been, will be or may be suspended, revoked, modified or limited, except in the cases of clauses (i), (ii),
(iii) and (iv) where such rejections, determinations, delays, requests, suspensions, revocations, modifications or limitations might not reasonably be expected to have, individually or in the aggregate, a Material Adverse Effect.

 (bb) Except to the extent disclosed in the Registration Statement and the Prospectus, to the Company’s knowledge, the
preclinical and clinical testing, application for marketing approval of, manufacture, distribution, promotion and sale of the products and Potential Products of the Company is in compliance, in all material respects, with all laws, rules and
regulations applicable to such activities, except for such non-compliance as would not, individually or in the aggregate, have a Material Adverse Effect. The descriptions of the results of such tests and trials contained in the Registration
Statement and the Prospectus are complete and accurate in all material respects such that there would be no untrue statement of a material fact or an omission of a material fact necessary to make the statements in the Registration Statement and
Prospectus, in light of the circumstances under which they are made, not misleading. The Company is not aware of any studies, tests or trials the results of which reasonably call into question the results of the tests and trials conducted by or on
behalf of the Company that are described or referred to in the Registration Statement or the Prospectus. Except to the extent disclosed in the Registration Statement and the Prospectus, the Company has not received notice of adverse finding, warning
letter or clinical hold notice from the FDA or any non-U.S. counterpart of any of the foregoing, or any untitled letter or other correspondence or notice from the FDA or any other governmental authority or agency or any institutional or ethical
review board alleging or asserting noncompliance with any law, rule or regulation applicable in any jurisdiction, except notices, letters, and correspondences and non-U.S. counterparts thereof alleging or asserting such noncompliance as would not,
individually or in the aggregate, have a Material Adverse Effect. Except to the extent disclosed in the Registration Statement and the Prospectus, the Company has not, either voluntarily or involuntarily, initiated, conducted or issued, or caused to
be initiated, conducted or issued, any recall, field correction, market withdrawal or replacement, safety alert, warning, “dear doctor” letter, investigator notice, or other notice or action relating to an alleged or potential lack of
safety or efficacy of any product or potential product of the Company, any alleged product defect of any product or potential product of the Company, or any violation of any material applicable law, rule, regulation or any clinical trial or
marketing license, approval, permit or authorization for any product or potential product of the Company, and the Company is not aware of any facts or information that would cause it to initiate any such notice or action and has no knowledge or
reason to believe that the FDA, the EMEA or any other governmental agency or authority or any institutional or ethical review board or other non-governmental authority intends to impose, require, request or suggest such notice or action. 

 

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 (cc) The Company is not an “investment company” within the meaning of the
Investment Company Act of 1940, as amended. 
 (dd) The Company’s systems of internal accounting controls taken as a whole
are sufficient to meet the broad objectives of internal accounting control insofar as those objectives pertain to the prevention or detection of errors or irregularities in amounts that would be material in relation to the Company’s financial
statements; and, to the best of the Company’s knowledge, neither the Company nor any employee or agent thereof has made any payment of funds of the Company or received or retained any funds, and no funds of the Company have been set aside to be
used for any payment, in each case in violation of any law, rule or regulation. 
 (ee) The Company is not involved in any labor
dispute and, to the knowledge of the Company, no such dispute has been threatened, except for such disputes as would not have a Material Adverse Effect on the Company, or subject the Company or its shareholders to any material liability or
disability. 
  

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 (ff) Except as disclosed in the Registration Statement or the Prospectus, (i) there has
been no storage, disposal, generation, manufacture, refinement, transportation, handling or treatment of toxic wastes, hazardous wastes or hazardous substances by the Company (or to the knowledge of the Company, any of their predecessors in
interest) at, upon or from any of the property now or previously owned or leased by the Company in violation of any applicable law, ordinance, rule, regulation, order, judgment, decree or permit or which would require remedial action under any
applicable law, ordinance, rule, regulation, order, judgment, decree or permit, except for any violation or remedial action which would not have a Material Adverse Effect; (ii) there has been no material spill, discharge, leak, emission,
injection, escape, dumping or release of any kind onto such property or into the environment surrounding such property of any toxic wastes, solid wastes, hazardous wastes or hazardous substances due to or caused by the Company, except for any such
spill, discharge, leak emission, injection, escape, dumping or release which would not have a Material Adverse Effect; and (iii) the terms “hazardous wastes,” “toxic wastes” and “hazardous substances” shall have
the meanings specified in any applicable local, state, federal and foreign laws or regulations with respect to environmental protection. 

(gg) There is and has been no failure on the part of the Company or any of the Company’s directors or officers, in their capacities
as such, to comply with any provision of the Sarbanes-Oxley Act of 2002 and the rules and regulations promulgated in connection therewith (the “Sarbanes-Oxley Act”), including without limitation Section 402 related to loans and
Sections 302 and 906 related to certifications. 
 ARTICLE II 

SALE AND DELIVERY OF SECURITIES 

2.1 Sale and Delivery of Securities. 

(a) On the basis of the representations, warranties and agreements herein contained, but subject to the terms and conditions herein set
forth, the Company agrees to issue and sell through the Sales Manager, as agent, and the Sales Manager agrees to sell, as agent for the Company, on a best efforts basis, shares of the Stock during the term of this Agreement on the terms set forth
herein. The Stock will be sold from time to time, pursuant to the Registration Statement and Prospectus and/or in any other manner permitted by law (including, without limitation, privately negotiated transactions) at prices prevailing at the time
of sale and in such amounts as directed by the Company and as agreed to by the Sales Manager. 
 (b) The Company or the Sales
Manager may, upon notice to the other party hereto by telephone (confirmed promptly by facsimile), at any time and from time to time suspend the offering of shares of the Stock; provided, however, that such suspension shall not affect
or impair the parties’ respective obligations with respect to the Stock sold hereunder prior to the giving of such notice. 

(c) The compensation to the Sales Manager for sales of shares of the Stock shall be at a fixed commission rate of four and one-half
percent (4.5%) of the gross sales price per share for the Stock sold under this Agreement, up to the first Seven Million Dollars ($7,000,000) of aggregate gross offering proceeds, and thereafter at a rate of three and one-half percent
(3.5%) of the gross sales price per share for all other sales of shares of the Stock sold under this Agreement. The remaining proceeds, after further deduction for any transaction fees imposed by any governmental or self-regulatory organization
in respect to such sale shall constitute the net proceeds to the Company for such Stock (the “Net Proceeds”). 
  

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 (d) The Company shall open and maintain a trading account (the “Trading Account”)
at a clearing agent designated by the Sales Manager to facilitate the transactions contemplated by this Agreement. The Company shall, with respect to each sale of shares of the Stock, effect delivery of the applicable number of shares of Stock to
the Trading Account, on or before the third business day (or such other day as is industry practice for regular-way trading) following each sale of the Stock (each, a “Settlement Date”). The Net Proceeds from the sale of the Stock shall be
available in the Trading Account following the settlement of the sale on the Settlement Date. The Sales Manager’s compensation shall be withheld from the sales proceeds on each Settlement Date and shall be paid to the Sales Manager. 

(e) At each Settlement Date, the Company shall be deemed to have affirmed each representation, warranty, covenant and other agreement
contained in this Agreement. Any obligation of the Sales Manager under this Agreement shall be subject to the continuing accuracy of the representations and warranties of the Company herein, to the performance by the Company of its obligations
hereunder and to the continuing satisfaction of the additional conditions specified in Article IV below. 
 (f) If the Company
shall default on its obligation to deliver Stock on any Settlement Date, the Company shall (i) hold the Sales Manager harmless against any loss, claim or damage arising from or as a result of such default by the Company and (ii) pay the
Sales Manager any commission to which it would otherwise be entitled absent such default. 
 ARTICLE III 

COVENANTS OF THE COMPANY 

3.1 The Company covenants and agrees with the Sales Manager that: 

(a) As promptly as practicable after the date of this Agreement, the Company will file a supplement to the Prospectus under Rule 424(b)
of the Act naming the Sales Manager, as an underwriter, to permit sales of the Stock under the Act. 
 (b) During the period in
which the Sales Agent has been requested to offer and sell Stock, the Company will notify the Sales Manager promptly of the time when any subsequent amendment to the Registration Statement has become effective or any subsequent supplement to the
Prospectus has been filed and of any request by the Commission for any amendment or supplement to the Registration Statement or the Prospectus or for additional information. The Company will prepare and file with the Commission, promptly upon the
Sales Manager’s reasonable request, any amendments or supplements to the Registration Statement or Prospectus that, in the Sales Manager’s reasonable opinion, may be necessary or advisable in connection with the sale of the Stock pursuant
to this Agreement. The Company will not file any amendment or supplement to the Registration Statement or Prospectus (other than a supplement to the Prospectus that (i) relates solely to the issuance of securities other than the Stock of the
Company pursuant to this Agreement and (ii) does not materially change the information about the Company or its business, operations, properties or financial condition disclosed in the Registration Statement or Prospectus previously thereto (an
“Excluded Supplement”)) unless a copy thereof has been submitted to the Sales Manager a reasonable period of time before the filing and the Sales Manager has not reasonably objected thereto; and it will notify the Sales Manager at the time
of filing thereof of any document that, upon filing, is deemed to be incorporated by reference in the Registration Statement or Prospectus (unless such document is available on the SEC’s EDGAR database, in which case no notification shall be
required). The Company will cause each amendment to the Registration Statement or supplement to the Prospectus, and each filing or report incorporated therein, to be prepared in form and substance as required by the Act, the Rules and Regulations,
the Exchange Act and the rules and regulations thereunder, and to be timely filed with the Commission. Any press releases or similar publicity by the Company related to this offering that is not covered by the preceding provisions of this
Section 3(b) must be reasonably acceptable to the Sales Manager. 
  

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 (c) The Company will advise the Sales Manager, promptly after it shall receive notice or
obtain knowledge thereof, of the issuance by the Commission of any stop order suspending the effectiveness of the Registration Statement, of the suspension of the qualification of the Stock for offering or sale in any jurisdiction, or of the
initiation or threatening of any proceeding for any such purpose; and it will promptly use its commercially reasonable efforts to prevent the issuance of any stop order or to obtain its withdrawal if such a stop order should be issued. 

(d) Within the time during which a prospectus relating to the Stock is required to be delivered under the Act, the Company will comply
with all requirements imposed upon it by the Act and by the Rules and Regulations, as from time to time in force, so far as necessary to permit the continuance of sales of or dealings in the Stock as contemplated by the provisions hereof and the
Prospectus, including compliance with the requirement that the Company has not sold within the twelve calendar months immediately prior to, and including, each sale of shares of the Stock, securities with an aggregate market value in excess of the
amount allowed under General Instruction I.B.6. of Form S-3 under the Act. If during such period any event occurs as a result of which the Prospectus, as then amended or supplemented, would include an untrue statement of a material fact or omit to
state a material fact necessary to make the statements therein, in the light of the circumstances then existing, not misleading, or if during such period it is necessary to amend or supplement the Registration Statement or Prospectus to comply with
the Act, the Company will promptly notify the Sales Manager to suspend the offering of shares of the Stock during such period and the Company will amend or supplement the Registration Statement or Prospectus (at the expense of the Company) so as to
correct such statement or omission or effect such compliance and will use commercially reasonable efforts to have any amendment or supplement to the Registration Statement or Prospectus declared effective as soon as possible, unless the Company has
reasonable business reasons to defer public disclosure of the relevant information. 
 (e) The Company will use commercially
reasonable efforts to qualify the Stock for sale under the securities laws of such jurisdictions as the Sales Manager designates in writing and to continue such qualifications in effect so long as required for the sale of the Stock, except that the
Company shall not be required in connection therewith to qualify as a foreign corporation or to execute a general consent to service of process in any jurisdiction. 

 

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 (f) The Company will furnish to the Sales Manager and its legal counsel (at the expense of
the Company) copies of the Registration Statement and the Prospectus during the period in which a prospectus relating to the Stock is required to be delivered under the Act, in each case as soon as available and in such quantities as the Sales
Manager may from time to time reasonably request, and in the case when the Trading Market is a national securities exchange, the Company will also furnish copies of the Prospectus to such exchange in accordance with Rule 153 under the Act.

 (g) The Company will make generally available to its security holders as soon as practicable, but in any event not later than
15 months after the end of the Company’s current fiscal quarter, an earnings statement (which need not be audited) covering a 12-month period that satisfies the provisions of Section 11(a) of the Act and Rule 158 of the Rules and
Regulations. 
 (h) The Company, whether or not the transactions contemplated hereunder are consummated or this Agreement is
terminated, will pay all of its expenses incident to the performance of its obligations hereunder (including, but not limited to, any transaction fees imposed by any governmental or self-regulatory organization with respect to transactions
contemplated by this Agreement and any blue sky fees) and will pay the expenses of printing all documents relating to the offering. The Company will reimburse the Sales Manager for its reasonable out-of-pocket costs and expenses incurred in
connection with entering into this Agreement, including, without limitation, reasonable travel, reproduction, printing and similar expenses, initial and ongoing due diligence, and reasonable fees and disbursements of its legal counsel, up to an
aggregate amount of $50,000. In addition, without limiting the foregoing, the Company will pay, or reimburse the Sales Manager for, any filing fees incurred by the Sales Manager in connection with filings (if any) required to be made by the Sales
Manager with FINRA. 
 (i) The Company will use commercially reasonable efforts to maintain the quotation of the Stock on the
Trading Market and to file with the Trading Market all documents and notices required by the Trading Market of companies quotations for which are reported by the Trading Market. 

(j) The Company will apply the Net Proceeds from the sale of the Stock as set forth in the Prospectus. 

(k) The Company will not, directly or indirectly, offer or sell any shares of common stock (other than the Stock) or securities
convertible into or exchangeable for, or any rights to purchase or acquire, common stock, during the period from the date of this Agreement through the final Settlement Date for the sale of shares of the Stock hereunder without (i) giving the
Sales Manager at least eight hours prior written notice specifying the nature of the proposed sale and the date of such proposed sale and (ii) suspending activity under this program for such period of time as may reasonably be determined by
agreement of the Company and the Sales Manager; provided, however, that no such notice and suspension shall be required in connection with the Company’s issuance or sale of (i) shares of common stock pursuant to any employee
or director stock option or benefits plan, stock ownership plan, dividend reinvestment plan, as such plans may be amended from time to time, (ii) common stock, options and equity-based awards issued pursuant to the exception contained in
Section 711(a) of the NYSE Amex Company Guide, and (iii) common stock issuable upon conversion of securities or the exercise of warrants, options or other rights in effect or outstanding on the date hereof. Notwithstanding the foregoing,
this paragraph (k) shall not apply during periods that the Company is neither selling Stock through the Sales Manager nor has requested the Sales Manager to sell Stock. 

 

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 (l) The Company will, at any time during the term of this Agreement, as supplemented from
time to time, advise the Sales Manager immediately after it shall have received notice or obtained knowledge thereof, of any information or fact that would materially alter or affect any opinion, certificate, letter and other document provided to
the Sales Manager pursuant to Article IV below. 
 (m) Each time that the Registration Statement or the Prospectus shall be
amended or supplemented (other than an Excluded Supplement) and on the dates specified in Section 4.1(f) below, the Company shall (unless the Company is not then selling Stock through the Sales Manager and has not requested the Sales Manager to
sell Stock) furnish or cause to be furnished to the Sales Manager forthwith a certificate, in form and substance satisfactory to the Sales Manager, to the effect that the statements contained in the certificates referred to in Section 4.1(f)
below that were last furnished to the Sales Manager are true and correct at the time of such amendment, supplement, filing, as the case may be, as though made at and as of such time (except that such statements shall be deemed to relate to the
Registration Statement and the Prospectus as amended and supplemented to such time) or, in lieu of such certificates, certificates of the same tenor as the certificates referred to in said Section 4.1(f) below, modified as necessary to relate
to the Registration Statement and the Prospectus as amended and supplemented to the time of delivery of such certificate. 
 (n)
Each time that a post-effective amendment to the Registration Statement is declared effective or the Company files an Annual Report on Form 10-K, and at such other times as may be reasonably requested by the Sales Manager, the Company shall (unless
the Company is not then selling Stock through the Sales Manager and has not requested the Sales Manager to sell Stock) furnish or cause to be furnished forthwith to the Sales Manager and to its legal counsel, a written opinion of Sheppard, Mullin,
Richter & Hamilton LLP (“Company Counsel”), or other counsel reasonably satisfactory to the Sales Manager, dated the date of effectiveness of such amendment or the date of filing with the Commission of such document, as the case
may be, in form and substance satisfactory to the Sales Manager, of the same tenor as the opinion referred to in Section 4.1(d) below, but modified as necessary to relate to the Registration Statement and the Prospectus as amended and
supplemented to the time of delivery of such opinion. In addition, at each such time, the Company shall cause to be forwarded to the Sales Manager such opinions of special counsel to the Company as may be reasonably requested by the Sales Manager.

 (o) Each time that a post-effective amendment to the Registration Statement is declared effective or the Company files an
Annual Report on Form 10-K, and at such other times as may be reasonably requested by the Sales Manager, the Company shall (unless the Company is not then selling Stock through the Sales Manager and has not requested the Sales Manager to sell Stock)
cause Marcum LLP, or other independent accountants then retained by the Company, forthwith to furnish to the Sales Manager a letter, dated the date of effectiveness of such amendment, or the date of filing of such supplement or other document with
the Commission, as the case may be, in form and substance satisfactory to the Sales Manager, of the same tenor as the letter referred to in Section 4.1(e) below but modified to relate to the Registration Statement and the Prospectus, as amended
and supplemented to the date of such letter. 
  

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 (p) The Company represents and agrees that, unless it obtains the prior consent of the Sales
Manager, and the Sales Manager represents and agrees that, unless it obtains the prior consent of the Company, it has not made and will not make any offer relating to shares of the Stock to be sold pursuant to this Agreement that would constitute an
Issuer Free Writing Prospectus, or that would otherwise constitute a “free writing prospectus” as defined in Rule 405, required to be filed with the Commission. Any such free writing prospectus consented to by the Company and the Sales
Manager is hereinafter referred to as a “Permitted Free Writing Prospectus.” The Company represents that it has treated and agrees that it will treat each Permitted Free Writing Prospectus as an “issuer free writing prospectus,”
as defined in Rule 433 (“Rule 433”), and has complied and will comply with the requirements of Rules 164 and 433, as applicable to any Permitted Free Writing Prospectus, including timely Commission filings where required, legending and
record keeping. 
 For the purposes of this Section, “Issuer Free Writing Prospectus” means any
“issuer free writing prospectus,” as defined in Rule 433 under the Act, relating to the Stock in the form filed or required to be filed with the Commission or, if not required to be filed, in the form retained in the Company’s records
pursuant to Rule 433(g). 
 ARTICLE IV 

CONDITIONS OF THE SALES MANAGER’S OBLIGATIONS 

4.1 The obligations of the Sales Manager to sell the Stock as provided in this Agreement shall be subject to the accuracy, as of the date
hereof, and as of each Settlement Date contemplated under this Agreement, of the representations and warranties of the Company in this Agreement, to the performance by the Company of its obligations in this Agreement and to the following additional
conditions: 
 (a) The Registration Statement has been declared effective. No stop order suspending the effectiveness of the
Registration Statement shall have been issued and no proceeding for that purpose shall have been instituted or, to the knowledge of the Company or the Sales Manager, threatened by the Commission, and any request of the Commission for additional
information (to be included in the Registration Statement or the Prospectus or otherwise) shall have been complied with to the Sales Manager’s reasonable satisfaction. The supplement to the Prospectus contemplated by Section 3.1(a) above
has been filed. 
 (b) The Sales Manager shall not have advised the Company that the disclosures in the Registration Statement
or the Prospectus are not reasonably acceptable to the Sales Manager. 
 (c) Except as contemplated in the Prospectus,
subsequent to the respective dates as of which information is given in the Registration Statement and the Prospectus, there shall not have been any material adverse change in the capital stock of the Company, or any material adverse change, or any
development that may reasonably be expected to cause a material adverse change, in the condition (financial or other), business, prospects, net worth or results of operations of the Company, or any adverse change in the rating assigned to any debt
securities of the Company, if any. 
  

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 (d) The Sales Manager shall have received at the date of the first sale of shares of the
Stock hereunder (the “Commencement Date”) and at every other date specified in Section 3.1(n) above, opinions of Company Counsel and special counsel, dated as of the Commencement Date and dated as of such other date, in form and
substance reasonably acceptable to the Sales Manager. 
 (e) At the Commencement Date and at such other dates specified in
Section 3.1(o) above, the Sales Manager shall have received a “comfort letter” from Marcum LLP, independent public accountants for the Company, or other independent accountants then retained by the Company, dated the date of delivery
thereof, in form and substance satisfactory to the Sales Manager. 
 (f) The Sales Manager shall have received from the Company
a certificate, or certificates, signed by (i) the Chief Financial Officer and (ii) the President and Chief Executive Officer or any Vice President of the Company, dated as of the Commencement Date and (unless the Company is not then
selling Stock through the Sales Manager and has not requested the Sales Manager to sell Stock) dated as of the first business day of each calendar month thereafter (each, a “Certificate Date”), to the effect that, to the best of their
knowledge based upon reasonable investigation: 
 (i) The representations and warranties of the Company in this
Agreement are true and correct, as if made at and as of the Commencement Date or the Certificate Date (as the case may be), and the Company has complied with all the agreements and satisfied all the conditions on its part to be performed or
satisfied at or prior to the Commencement Date and each such Certificate Date (as the case may be); 
 (ii) No
stop order suspending the effectiveness of the Registration Statement has been issued, and no proceeding for that purpose has been instituted or, to the knowledge of such officer after due inquiry, is threatened, by the Commission; 

(iii) Since the date of this Agreement there has occurred no event required to be set forth in an amendment or supplement
to the Registration Statement or Prospectus that has not been so set forth and there has been no document required to be filed under the Exchange Act and the rules and regulations of the Commission thereunder that upon such filing would be deemed to
be incorporated by reference in the Prospectus that has not been so filed; and 
 (iv) Since the date of this
Agreement, there has not been any material adverse change in the assets or properties, business, prospects, results of operations, or condition (financial or otherwise) of the Company, which has not been described in an amendment or supplement to
the Registration Statement or Prospectus (directly or by incorporation). 
  

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 (g) At the Commencement Date and on each Settlement Date, the Company shall have furnished
to the Sales Manager such appropriate further information, officers’ certificates and similar documents as the Sales Manager may reasonably request. 

(h) At the Commencement Date and on each Settlement Date, the Company shall have listed for quotation the Stock on the Trading Market.

 All such opinions, certificates, letters and other documents will be in compliance with the provisions hereof only if they
are satisfactory in form and substance to the Sales Manager. The Company will furnish the Sales Manager with such conformed copies of such opinions, certificates, letters and other documents, as the Sales Manager shall reasonably request.

 ARTICLE V 

INDEMNIFICATION AND CONTRIBUTION 

5.1 The Company agrees to indemnify and hold harmless the Sales Manager and each person, if any, who controls the Sales Manager within
the meaning of Section 15 of the Act or Section 20 of the Exchange Act (collectively, the “Sales Manager Indemnitees”), as follows: 

(a) against any and all loss, liability, claim, damage and expense whatsoever, as incurred, arising out of any untrue statement or
alleged untrue statement of a material fact contained in the Registration Statement (or any amendment thereto), or the omission or alleged omission therefrom of a material fact required to be stated therein or necessary to make the statements
therein not misleading or arising out of any untrue statement or alleged untrue statement of a material fact contained in any preliminary prospectus or the Prospectus (or any amendment or supplement thereto) or the omission or alleged omission
therefrom of a material fact necessary in order to make the statements therein, in the light of the circumstances under which they were made, not misleading; 

(b) against any and all loss, liability, claim, damage and expense whatsoever, as incurred, to the extent of the aggregate amount paid in
settlement of any litigation, or any investigation or proceeding by any governmental agency or body, commenced or threatened, or of any claim whatsoever based upon any such untrue statement or omission, or any such alleged untrue statement or
omission, if such settlement is effected with the written consent of the Company; and 
 (c) against any and all expense
whatsoever, as incurred (including, subject to Section 5.3 below, the reasonable fees and disbursements of legal counsel chosen by the Sales Manager), reasonably incurred in investigating, preparing or defending against any litigation, or any
investigation or proceeding by any governmental agency or body, commenced or threatened, or any claim whatsoever based upon any such untrue statement or omission, or any such alleged untrue statement or omission, to the extent that any such expense
is not paid under (i) or (ii) above; 
 provided, however, that this indemnity agreement shall not apply to any loss,
liability, claim, damage or expense to the extent arising out of any untrue statement or omission or alleged untrue statement or omission made in reliance upon and in conformity with written information furnished to the Company by the Sales Manager
expressly for use in the Registration Statement (or any amendment thereto) or any preliminary prospectus or the Prospectus (or any amendment or supplement thereto). 

 

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 5.2 The Sales Manager agrees to indemnify and hold harmless the Company and its directors
and each officer of the Company who signed the Registration Statement, and each person, if any, who controls the Company within the meaning of Section 15 of the Act or Section 20 of the Exchange Act against any and all loss, liability,
claim, damage and expense described in the indemnity contained in Section 5.1 above, as incurred, but only with respect to untrue statements or omissions, or alleged untrue statements or omissions, made in the Registration Statement (or any
amendments thereto) or any preliminary prospectus or the Prospectus (or any amendment or supplement thereto) in reliance upon and in conformity with written information furnished to the Company by the Sales Manager expressly for use in the
Registration Statement (or any amendment thereto) or such preliminary prospectus or the Prospectus (or any amendment or supplement thereto). The total liability of the Sales Manager under this Section 5.2 shall not exceed the Net Proceeds in
respect of the Stock sold by the Sales Manager that is the subject of the dispute. 
 5.3 Any indemnified party that proposes to
assert the right to be indemnified under this Article V will, promptly after receipt of notice of commencement of any action against such party in respect of which a claim is to be made against an indemnifying party or parties under this Article V,
notify each such indemnifying party of the commencement of such action, enclosing a copy of all papers served, but the omission so to notify such indemnifying party will not relieve the indemnifying party from any liability that it might have to any
indemnified party to the extent it is not materially prejudiced as a result thereof. If any such action is brought against any indemnified party and it notifies the indemnifying party of its commencement, the indemnifying party will be entitled to
participate in and, to the extent that it elects by delivering written notice to the indemnified party promptly after receiving notice of the commencement of the action from the indemnified party, jointly with any other indemnifying party similarly
notified, to assume the defense of the action, with legal counsel reasonably satisfactory to the indemnified party, and after notice from the indemnifying party to the indemnified party of its election to assume the defense, the indemnifying party
will not be liable to the indemnified party for any legal or other expenses except as provided below. The indemnified party will have the right to employ its own legal counsel in any such action, but the fees, expenses and other charges of such
legal counsel will be at the expense of such indemnified party unless (1) the employment of legal counsel by the indemnified party has been authorized in writing by the indemnifying party, (2) the indemnified party has reasonably concluded
(based on the written advice of legal counsel) that there may be legal defenses available to it or other indemnified parties that are different from or in addition to those available to the indemnifying party, (3) a conflict or potential
conflict exists (based on the written advice of legal counsel to the indemnified party) between the indemnified party and the indemnifying party (in which case the indemnifying party will not have the right to direct the defense of such action on
behalf of the indemnified party) or (4) the indemnifying party has not in fact employed legal counsel to assume the defense of such action within a reasonable time after receiving notice of the commencement of the action, in each of which cases
the reasonable fees, disbursements and other charges of legal counsel will be at the expense of the indemnifying party or parties. It is understood that the indemnifying party or parties shall not, in connection with any proceeding or related
proceedings in the same jurisdiction, be liable for the reasonable fees, disbursements and other charges of more than one separate firm (together with associated local counsel, if any) at any one time for all such indemnified party or parties. All
such fees, disbursements and other charges will be reimbursed by the indemnifying party promptly as they are incurred. An indemnifying party will not be liable for any settlement of any action or claim effected without its written consent (which
consent will not be unreasonably withheld). 
  

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 5.4 In order to provide for just and equitable contribution in circumstances in which the
indemnification provided for in the foregoing paragraphs of this Article V is applicable in accordance with its terms but for any reason is held to be unavailable from the Company or the Sales Manager, the Company and the Sales Manager will
contribute to the total losses, claims, liabilities, expenses and damages (including any investigative, legal and other expenses reasonably incurred in connection with, and any amount paid in settlement of, any action, suit or proceeding or any
claim asserted, but after deducting any contribution received by the Company from persons other than the Sales Manager, such as persons who control the Company within the meaning of the Act, officers of the Company who signed the Registration
Statement and directors of the Company, who also may be liable for contribution) to which the Company and the Sales Manager may be subject in such proportion as shall be appropriate to reflect the relative benefits received by the Company on the one
hand and the Sales Manager on the other. The relative benefits received by the Company on the one hand and the Sales Manager on the other hand shall be deemed to be in the same proportion as the total net proceeds from the offering (before deducting
expenses) received by the Company bear to the total compensation (before deducting expenses) received by the Sales Manager from the sale of shares of the Stock on behalf of the Company. If, but only if, the allocation provided by the foregoing
sentence is not permitted by applicable law, the allocation of contribution shall be made in such proportion as is appropriate to reflect not only the relative benefits referred to in the foregoing sentence but also the relative fault of the
Company, on the one hand, and the Sales Manager, on the other, with respect to the statements or omission which resulted in such loss, claim, liability, expense or damage, or action in respect thereof, as well as any other relevant equitable
considerations with respect to such offering. Such relative fault shall be determined by reference to whether the untrue or alleged untrue statement of a material fact or omission or alleged omission to state a material fact relates to information
supplied by the Company or the Sales Manager, the intent of the parties and their relative knowledge, access to information and opportunity to correct or prevent such statement or omission. The Company and the Sales Manager agree that it would not
be just and equitable if contributions pursuant to this Section 5.4 were to be determined by pro rata allocation or by any other method of allocation, which does not take into account, the equitable considerations referred to herein. The amount
paid or payable by an indemnified party as a result of the loss, claim, liability, expense or damage, or action in respect thereof, referred to above in this Section 5.4 shall be deemed to include, for the purpose of this Section 5.4, any
legal or other expenses reasonably incurred by such indemnified party in connection with investigating or defending any such action or claim. Notwithstanding the foregoing provisions of this Section 5.4, the Sales Manager shall not be required
to contribute any amount in excess of the amount by which the total actual sales price at which Stock sold by the Sales Manager exceeds the amount of any damages that the Sales Manager has otherwise been required to pay by reason of such untrue or
alleged untrue statement or omission or alleged omission and no person found guilty of fraudulent misrepresentation (within the meaning of Section 11(f) of the Act) will be entitled to contribution from any person who was not guilty of such
fraudulent misrepresentation. For purposes of this Section 5.4, any person who controls a party to this Agreement within the meaning of the Act will have the same rights to contribution as that party, and each officer and director of the
Company who signed the Registration Statement will have the same rights to contribution as the Company, subject in each case to the provisions hereof. Any party entitled to contribution, promptly after receipt of notice of commencement of any action
against such party in respect of which a claim for contribution may be made under this Section 5.4, will notify any such party or parties from whom contribution may be sought, but the omission so to notify will not relieve that party or parties
from whom contribution may be sought from any other obligation it or they may have under this Section 5.4. No party will be liable for contribution with respect to any action or claim settled without its written consent (which consent will not
be unreasonably withheld). 
  

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 5.5 The indemnity and contribution provided by this Article V shall not relieve the Company
and the Sales Manager from any liability the Company and the Sales Manager may otherwise have (including, without limitation, any liability the Sales Manager may have for a breach of its obligations under Article II above). 

ARTICLE VI 

REPRESENTATIONS AND AGREEMENTS TO SURVIVE DELIVERY 

6.1 All representations, warranties and agreements of the Company herein or in certificates delivered pursuant hereto, and the agreements
of the Sales Manager contained in Article V above, shall remain operative and in full force and effect regardless of any investigation made by or on behalf of the Sales Manager or any controlling persons, or the Company (or any of their officers,
directors or controlling persons), and shall survive delivery of and payment for the Stock. 
 ARTICLE VII 

TERMINATION 

7.1 The Company shall have the right, by giving notice as hereinafter specified, to terminate this Agreement in its sole discretion at
any time. Any such termination shall be without liability of any party to any other party except that the provisions of Section 3.1(h), Article V and Article VI above shall remain in full force and effect notwithstanding such termination.

 7.2 The Sales Manager shall have the right, by giving notice as hereinafter specified, to terminate this Agreement in its
sole discretion at any time. Any such termination shall be without liability of any party to any other party except that the provisions of Section 3.1(h), Article V and Article VI above shall remain in full force and effect notwithstanding such
termination. 
 7.3 This Agreement shall remain in full force and effect unless terminated pursuant to Sections 7.1 or 7.2 above
or otherwise by mutual agreement of the parties; provided that any such termination by mutual agreement shall in all cases be deemed to provide that Section 3.1(h), Article V and Article VI above shall remain in full force and effect.

  

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 7.4 Any termination of this Agreement shall be effective on the date specified in such
notice of termination; provided that such termination shall not be effective until the close of business on the date of receipt of such notice by the Sales Manager or the Company, as the case may be. If such termination shall occur during a period
when sales of shares of the Stock are being made pursuant to this Agreement, any sales of shares of the Stock made prior to the termination of this Agreement shall settle in accordance with the provisions of this Agreement. 

ARTICLE VIII 

NOTICES 

8.1 All notices or communications hereunder shall be in writing and if sent to the Sales Manager shall be mailed,
delivered or facsimiled and confirmed to the Sales Manager at Brinson Patrick Securities Corporation, 1515 Broadway,
11th Floor, New York, New York 10036, facsimile number
(212) 453-5555, Attention: Corporate Finance, or if sent to the Company, shall be mailed, delivered or telecopied and confirmed to the Company at 12255 El Camino Real, Suite 250, San Diego, California 92130, Attention: Tyler M. Dylan; facsimile
number (858) 436-1011. Each party to this Agreement may change such address for notices by sending to the parties to this Agreement written notice of a new address for such purpose. 

ARTICLE IX 

MISCELLANEOUS 

9.1 This Agreement shall inure to the benefit of and be binding upon the Company and the Sales Manager and their respective successors
and the controlling persons, officers and directors referred to in Article V above, and no other person will have any right or obligation hereunder. 

9.2 Indemnification pursuant to Section 5.1 hereof will not constitute the exclusive remedy available to the Sales Manager
Indemnitees for any breach or alleged breach by the Company of any representation, warranty, covenant or agreement contained in this Agreement. 

9.3 This Agreement constitutes the entire agreement and supersedes all other prior and contemporaneous agreements and undertakings, both
written and oral, between the parties hereto with regard to the subject matter hereof. 
 9.4 THIS AGREEMENT SHALL BE GOVERNED
BY, AND CONSTRUED IN ACCORDANCE WITH, THE INTERNAL LAWS OF THE STATE OF NEW YORK WITHOUT REGARD TO THE PRINCIPLES OF CONFLICTS OF LAWS. 

9.5 This Agreement may be executed in two or more counterparts, each of which shall be deemed an original, but all of which together
shall constitute one and the same instrument. The parties agree that this Agreement will be considered signed when the signature of a party is delivered by facsimile transmission. Such facsimile transmission shall be treated in all respects as
having the same effect as an original signature. 
 [Remainder of this page intentionally left blank.] 

 

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 IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be duly executed by
their respective authorized officers as of the date hereof. 
  

			
	CARDIUM THERAPEUTICS, INC.
		
	By:	 	 /s/ Tyler Dylan-Hyde

		 	Name: Tyler Dylan-Hyde
		 	Title: Chief Business Officer
	
	BRINSON PATRICK SECURITIES CORPORATION
		
	By:	 	 /s/ Todd Wyche

		 	Name: Todd Wyche
		 	Title: Managing Director


  

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 SCHEDULE 1.1(f) 

List of Significant Subsidiaries 

Tissue Repair Company 
  

 -1-