Exhibit
4.1


 


REGISTRATION
RIGHTS AGREEMENT


 


THIS
REGISTRATION RIGHTS AGREEMENT (this “Agreement”), dated as of December 5, 2019, is entered into by and
between POLARITYTE, INC., a Delaware corporation (the “Company”), and KEYSTONE CAPITAL PARTNERS,
LLC, a Delaware limited liability company (together with its permitted assigns, the “Investor”). Capitalized
terms used herein and not otherwise defined herein shall have the respective meanings set forth in the Purchase Agreement by and
between the parties hereto, dated as of the date hereof (as amended, restated, supplemented or otherwise modified from time to
time, the “Purchase Agreement”).


 


W
H E R E A S:


 


A.
Upon the terms and subject to the conditions of the Purchase Agreement, the Company has agreed to issue to the Investor, and the
Investor has agreed to purchase, up to Twenty-Five Million Dollars ($25,000,000) of the Company’s common stock, par value
$0.001 per share (the “Common Stock”), pursuant to Section 2 of the Purchase Agreement (such shares, the “Purchase
Shares”).


 


B.
To induce the Investor to enter into the Purchase Agreement, the Company has agreed to provide certain registration rights under
the Securities Act of 1933, as amended, and the rules and regulations thereunder, or any similar successor statute (collectively,
the “Securities Act”), and applicable state securities laws.


 


NOW,
THEREFORE, in consideration of the promises and the mutual covenants contained herein and other good and valuable consideration,
the receipt and sufficiency of which are hereby acknowledged, the Company and the Investor hereby agree as follows:


 


1.
DEFINITIONS.


 


For
purposes of this Agreement, the following terms shall have the following meanings:


 


(a)
“Register,” “Registered,” and “Registration” refer to a registration
effected by preparing and filing one or more registration statements of the Company in compliance with the Securities Act and
pursuant to Rule 415 under the Securities Act or any successor rule providing for offering securities on a continuous basis (“Rule
415”), and the declaration or ordering of effectiveness of such registration statement(s) by the U.S. Securities and
Exchange Commission (the “SEC”).


 


(b)
“Registrable Securities” means, without regard to any limitation on purchases under the Purchase Agreement,
such number of Purchase Shares as reasonably determined by the Company, which may from time to time be, issued or issuable to
the Investor upon purchases of the Available Amount under the Purchase Agreement, and any Common Stock issued or issuable with
respect to the Purchase Shares or the Purchase Agreement as a result of any stock split, stock dividend, recapitalization, exchange
or similar event; provided, however, that with respect to any particular Registrable Security, such security shall
cease to be a Registrable Security when it has been effectively registered under the Securities Act and disposed of pursuant thereto.


 


(c)
“Registration Statement” means the Shelf Registration Statement and any other registration statement of the
Company that Registers Registrable Securities, including a New Registration Statement, as amended when each became effective,
including all documents filed as part thereof or incorporated by reference therein, and including any information contained in
a Prospectus subsequently filed with the SEC in relation to Registrable Securities.


 






    	 



    	 



    

 


(d)
“Shelf Registration Statement” means the Company’s existing Registration Statement on Form S-3 (File
No. 333-229584).


 


2.
REGISTRATION.


 


(a)
Mandatory Registration. The Company agrees that it shall, within the time required under Rule 424(b) under the Securities
Act, file with the SEC the Initial Prospectus Supplement pursuant to Rule 424(b) under the Securities Act specifically relating
to the transactions contemplated by, and describing the material terms and conditions of, the Transaction Documents, containing
information previously omitted at the time of effectiveness of the Registration Statement in reliance on Rule 430B under the Securities
Act, and disclosing all information relating to the transactions contemplated hereby required to be disclosed in the Registration
Statement and the Prospectus as of the date of the Initial Prospectus Supplement, including, without limitation, information required
to be disclosed in the section captioned “Plan of Distribution” in the Prospectus. The Investor acknowledges
that it will be identified in the Initial Prospectus Supplement as an underwriter within the meaning of Section 2(a)(11) of the
Securities Act. The Company shall permit the Investor to review and comment upon the Initial Prospectus Supplement at least two
(2) Business Days prior to its filing with the SEC, the Company shall give due consideration to all such comments, and the Company
shall not file the Initial Prospectus Supplement with the SEC in a form to which the Investor reasonably objects. The Investor
shall use its reasonable best efforts to comment upon the Initial Prospectus Supplement within one (1) Business Day from the date
the Investor receives the final pre-filing draft version thereof from the Company. The Investor shall furnish to the Company such
information regarding itself, the Securities held by it and the intended method of distribution thereof, including any arrangement
between the Investor and any other Person relating to the sale or distribution of the Securities, as shall be reasonably requested
by the Company in connection with the preparation and filing of the Initial Prospectus Supplement, and shall otherwise cooperate
with the Company as reasonably requested by the Company in connection with the preparation and filing of the Initial Prospectus
Supplement with the SEC.


 


(b)
Effectiveness. The Company shall use its reasonable best efforts to keep the Registration Statement effective under the
Securities Act (including through any necessary renewals), and to keep the Registration Statement and the Prospectus current and
available (including through any necessary renewals) for issuances and sales of all possible Registrable Securities by the Company
to the Investor, at all times until the earlier of (i) the date on which no Available Amount remains and, if applicable, all Registrable
Securities covered by the Registration Statement may be sold without volume restrictions pursuant to Rule 144 promulgated under
the Securities Act; and (ii) 180 days following the earlier of (A) the Maturity Date and (B) the date of termination of the Purchase
Agreement (the “Registration Period”). Without limiting the generality of the foregoing, during the Registration
Period, the Company shall (a) take all action necessary to cause the Common Stock to continue to be Registered as a class of securities
under Section 12(b) of the Exchange Act and shall not take any action or file any document (whether or not permitted by the Exchange
Act) to terminate or suspend such registration and (b) file or furnish on or before their respective due dates all reports and
other documents required to be filed or furnished by the Company pursuant to Sections 13(a), 13(c), 14, 15(d) or any other provision
of or under the Exchange Act, and shall not take any action or file any document (whether or not permitted by the Exchange Act)
to terminate or suspend its reporting and filing obligations under the Exchange Act. The Registration Statement (including any
amendments or supplements thereto and prospectuses contained therein) shall not contain any untrue statement of a material fact
or omit to state a material fact necessary to make the statements therein, in the light of the circumstances then existing, not
misleading.


 






    	2



    	 



    

 


(c)
Prospectus Amendments or Supplements. Except as provided in this Agreement and other than periodic and current reports
required to be filed pursuant to the Exchange Act, the Company shall not file with the SEC any amendment to the Registration Statement
or any supplement to the Base Prospectus that refers to the Investor, the Transaction Documents or the transactions contemplated
thereby (including, without limitation, any Prospectus Supplement filed in connection with the transactions contemplated by the
Transaction Documents), until (a) the Company affords the Investor the opportunity to review and comment thereon at least two
(2) Business Days prior to filing with the SEC, (b) the Company gives due consideration to any comments thereon received from
the Investor or its counsel, and (c) the Investor has not reasonably objected to such filing within one (1) Business Day of receiving
a copy of the same, unless the Company reasonably has determined that it is necessary to amend the Registration Statement or make
any supplement to the Prospectus to comply with the Securities Act or any other applicable law or regulation, in which case the
Company shall promptly (but in no event later than 24 hours prior to filing) so inform the Investor, the Investor shall be provided
with a reasonable opportunity to review and comment upon any disclosure referring to the Investor, the Transaction Documents or
the transactions contemplated thereby, as applicable, and the Company shall expeditiously furnish to the Investor a copy thereof.
In addition, for so long as, in the reasonable opinion of counsel for the Investor, the Prospectus is required to be delivered
in connection with any acquisition or sale of Securities by the Investor, the Company shall not file any Prospectus Supplement
with respect to the Securities without furnishing to the Investor as many copies of such Prospectus Supplement, together with
the Prospectus, as the Investor may reasonably request.


 


(d)
Sufficient Number of Shares Registered. In the event the number of shares available under the Shelf Registration Statement
is insufficient to cover the Registrable Securities, the Company shall, to the extent necessary and permissible, amend the Shelf
Registration Statement or file a new registration statement (together with any prospectuses or prospectus supplements thereunder,
a “New Registration Statement”), so as to cover all of such Registrable Securities as soon as reasonably practicable,
but in any event not later than ten (10) Business Days after the necessity therefor arises. The Company shall use its reasonable
best efforts to have such amendment or New Registration Statement become effective as soon as reasonably practicable following
the filing thereof.


 


(e)
Offering. If the SEC seeks to characterize any offering pursuant to a Registration Statement filed pursuant to this Agreement
as constituting an offering of securities that does not permit such Registration Statement to become effective and to be used
by the Investor under Rule 415 at then-prevailing market prices (and not fixed prices), or if after the filing of the Initial
Prospectus Supplement with the SEC pursuant to Section 2(a), the Company is otherwise required by the Staff or the SEC to reduce
the number of Registrable Securities included in such initial Registration Statement, then the Company shall reduce the number
of Registrable Securities to be included in such initial Registration Statement (with the prior consent, which shall not be unreasonably
withheld, of the Investor and its legal counsel as to the specific Registrable Securities to be removed therefrom) until such
time as the SEC shall so permit such Registration Statement to become effective and be used as aforesaid. In the event of any
reduction in Registrable Securities pursuant to this paragraph, the Company shall file one or more New Registration Statements
in accordance with Section 2(d) until such time as all Registrable Securities have been included in Registration Statements that
have been declared effective and the prospectuses contained therein is available for use by the Investor. Notwithstanding any
provision herein or in the Purchase Agreement to the contrary, the Company’s obligations to register Registrable Securities
(and any related condition to the Investor’s obligations) shall be qualified as necessary to comport with any requirement
of the SEC as addressed in this Section 2(e).


 






    	3



    	 



    

 


3.
RELATED OBLIGATIONS.


 


With
respect to the Registration Statement and whenever any Registrable Securities are to be Registered pursuant to Section 2, including
on the Shelf Registration Statement or on any New Registration Statement, the Company shall use its reasonable best efforts to
effect the registration of the Registrable Securities in accordance with the intended method of disposition thereof and, pursuant
thereto, the Company shall have the following obligations:


 


(a)
Notifications. The Company will notify the Investor promptly of the time when any subsequent amendment to the Shelf Registration
Statement or any New Registration Statement, other than documents incorporated by reference, has been filed with the SEC and/or
has become effective or where a receipt has been issued therefor or any subsequent supplement to a Prospectus has been filed and
of any request by the SEC for any amendment or supplement to the Registration Statement, any New Registration Statement or any
Prospectus or for additional information.


 


(b)
Amendments. The Company will prepare and file with the SEC, promptly upon the Investor’s request, any amendments
or supplements to the Shelf Registration Statement, any New Registration Statement or any Prospectus, as applicable, that, in
the reasonable opinion of the Investor and the Company, may be necessary or advisable in connection with any acquisition or sale
of Registrable Securities by the Investor (provided, however, that the failure of the Investor to make such request
shall not relieve the Company of any obligation or liability hereunder).


 


(c)
Investor Review. The Company will not file any amendment or supplement to the Registration Statement, any New Registration
Statement or any Prospectus, other than documents incorporated by reference, relating to the Investor, the Registrable Securities
or the transactions contemplated hereby unless (A) the Investor shall have been advised and afforded the opportunity to review
and comment thereon at least two (2) Business Days prior to filing with the SEC, (B) the Company shall have given due consideration
to any comments thereon received from the Investor or its counsel and (C) the Investor has not reasonably objected thereto (provided,
however, that the failure of the Investor to make such objection shall not relieve the Company of any obligation or liability
hereunder), and the Company will furnish to the Investor at the time of filing thereof a copy of any document that upon filing
is deemed to be incorporated by reference into the Registration Statement or any Prospectus, except for those documents available
via EDGAR.


 


(d)
Form S-3. The Company will cause each amendment or supplement to the Prospectus, other than documents incorporated by reference,
to be filed with the SEC as required pursuant to the rules of Form S-3.


 


(e)
Copies Available. The Company will furnish to the Investor and its counsel (at the expense of the Company) copies of the
Registration Statement, the Prospectus (including all documents incorporated by reference therein), any Prospectus Supplement,
any New Registration Statement and all amendments and supplements to the Registration Statement, the Prospectus or any New Registration
Statement that are filed with the SEC during the Registration Period (including all documents filed with or furnished to the SEC
during such period that are deemed to be incorporated by reference therein), in each case as soon as reasonably practicable and
in such quantities as the Investor may from time to time reasonably request and, at the Investor’s request, will also furnish
copies of the Prospectus to each exchange or market on which sales of the Registrable Securities may be made; provided,
however, that the Company shall not be required to furnish any document (other than the Prospectus) to the Investor to
the extent such document is available on EDGAR.


 


(f)
Qualification. The Company shall take all such action, if any, as is reasonably necessary in order to obtain an exemption
for or to qualify the sale of the Purchase Shares to the Investor under this Agreement and any subsequent resale of any Purchase
Shares by the Investor, in each case, under applicable securities or “Blue Sky” laws of the states of the United
States in such states as is reasonably requested by the Investor during the Registration Period, and shall provide evidence of
any such action so taken to the Investor. During the Registration Period, the Company shall promptly notify the Investor of the
receipt by the Company of any notification with respect to the suspension of the registration or qualification of any of the Registrable
Securities for sale under the securities or “blue sky” laws of any jurisdiction in the United States or its
receipt of actual notice of the initiation or threat of any proceeding for such purpose.


 






    	4



    	 



    

 


(g)
Notification of Stop Orders; Material Changes. The Company shall advise the Investor promptly (but in no event later than
24 hours) and shall confirm such advice in writing, in each case: (i) of the Company’s receipt of notice of any request
by the SEC or any other federal or state governmental authority for amendment of or a supplement to the Registration Statement
or any Prospectus or for any additional information; (ii) of the Company’s receipt of notice of the issuance by the SEC
or any other federal or state governmental authority of any stop order suspending the effectiveness of the Registration Statement
or prohibiting or suspending the use of the Prospectus or Prospectus Supplement, or any New Registration Statement, or of the
Company’s receipt of any notification of the suspension of qualification of the Registrable Securities for offering or sale
in any jurisdiction or the initiation or contemplated initiation of any proceeding for such purpose; and (iii) of the Company
becoming aware of the happening of any event, which makes any statement of a material fact made in the Registration Statement
or any Prospectus untrue or which requires the making of any additions to or changes to the statements then made in the Registration
Statement or any Prospectus in order to state a material fact required by the Securities Act to be stated therein or necessary
in order to make the statements then made therein (in the case of any Prospectus, in light of the circumstances under which they
were made) not misleading, or of the necessity to amend the Registration Statement or any Prospectus to comply with the Securities
Act or any other law. The Company shall not be required to disclose to the Investor the substance or specific reasons of any of
the events set forth in clauses (i) through (iii) of the immediately preceding sentence, but rather, shall only be required to
disclose that the event has occurred. If at any time the SEC, or any other federal or state governmental authority shall issue
any stop order suspending the effectiveness of the Registration Statement or prohibiting or suspending the use of the Prospectus
or Prospectus Supplement, the Company shall use commercially reasonable efforts to obtain the withdrawal of such order at the
earliest possible time. The Company shall furnish to the Investor, without charge, a copy of any correspondence from the SEC or
the staff of the SEC, or any other federal or state governmental authority to the Company or its representatives relating to the
Shelf Registration Statement, any New Registration Statement or any Prospectus, or Prospectus Supplement as the case may be. The
Company shall not deliver to the Investor any Purchase Notice, and the Investor shall not be obligated to purchase any shares
of Common Stock under this Agreement, during the continuation or pendency of any of the foregoing events. If at any time the SEC
shall issue any stop order suspending the effectiveness of the Registration Statement or prohibiting or suspending the use of
the Prospectus or any Prospectus Supplement, the Company shall use its commercially reasonable efforts to obtain the withdrawal
of such order at the earliest possible time. The Company shall furnish to the Investor, without charge, a copy of any correspondence
from the SEC or the staff of the SEC to the Company or its representatives relating to the Registration Statement or the Prospectus,
as the case may be.


 


(h)
Listing on the Principal Market. The Company shall promptly secure the listing, or conditional listing as applicable, of
all of the Purchase Shares issued or issuable to the Investor hereunder on the Principal Market (subject to standard listing conditions,
if any, for transactions of this nature, official notice of issuance and the Exchange Cap) and upon each other national securities
exchange or automated quotation system, if any, upon which the Common Stock are then listed, and shall use commercially reasonable
efforts to maintain, so long as any Common Stock shall be so listed, such listing of all such Registrable Securities from time
to time issuable hereunder. The Company shall use commercially reasonable efforts to maintain the listing of the Common Stock
on the Principal Market and shall comply in all material respects with the Company’s reporting, filing and other obligations
under the bylaws or rules and regulations of the Principal Market. Neither the Company nor any of its Subsidiaries shall take
any action that would reasonably be expected to result in the delisting or suspension of the Common Stock on the Principal Market.
The Company shall promptly, and in no event later than the following Business Day, provide to the Investor copies of any notices
it receives from the Principal Market regarding the continued eligibility of the Common Stock for listing on the Principal Market;
provided, however, that the Company shall not provide the Investor copies of any such notice that the Company reasonably
believes constitutes material non-public information and the Company would not be required to publicly disclose such notice in
any report or statement filed with the SEC and under the Exchange Act or the Securities Act. The Company shall pay all fees and
expenses in connection with satisfying its obligations under this Section 3(h).


 






    	5



    	 



    

 


(i)
Delivery of Shares. The Company shall cooperate with the Investor to facilitate the timely preparation and delivery of
DWAC Shares (not bearing any restrictive legend) representing the Registrable Securities to be offered pursuant to the Shelf Registration
Statement or any New Registration Statement and enable such DWAC Shares to be in such denominations or amounts as the Investor
may reasonably request and registered in such names as the Investor may request.


 


(j)
Transfer Agent. The Company shall at all times maintain the services of the Transfer Agent with respect to its Common Stock.


 


(k)
Approvals. The Company shall use commercially reasonable efforts to cause the Registrable Securities covered by any Registration
Statement to be registered with or approved by such other governmental agencies or authorities in the United States as may be
necessary to consummate the disposition of such Registrable Securities.


 


(l)
Confirmation of Effectiveness. If reasonably requested by the Investor at any time, the Company shall deliver to the Investor
a written confirmation from the Company’s counsel of whether or not the effectiveness of such Registration Statement has
lapsed at any time for any reason (including, without limitation, the issuance of a stop order) and whether or not the Registration
Statement is currently effective and available to the Company for sale of all of the Registrable Securities.


 


(m)
Further Assurances. The Company agrees to take all other reasonable actions as necessary and reasonably requested by the
Investor to expedite and facilitate disposition by the Investor of Registrable Securities pursuant to any Registration Statement.


 


(n)
Suspension of Sales. The Investor agrees that, upon receipt of any notice from the Company of the existence of any suspension
or stop order as set forth in Sections 3(f) or 3(g), the Investor will immediately discontinue disposition of Registrable Securities
pursuant to any Registration Statement covering such Registrable Securities until the Investor’s receipt of the copies of
a notice regarding the resolution or withdrawal of the suspension or stop order as contemplated by Section 3(f) or 3(g).


 


4.
OBLIGATIONS OF THE INVESTOR.


 


(a)
Investor Information. The Investor has furnished to the Company in Exhibit A hereto such information regarding itself,
the Registrable Securities held by it, the Registrable Securities held by it and the intended method of disposition thereof, including
any arrangement between the Investor and any other Person relating to the sale or distribution of the Securities, as required
to effect the registration of such Registrable Securities and shall execute such documents in connection with such registration
as the Company may reasonably request. The Company shall notify the Investor in writing of any other information the Company reasonably
requires from the Investor in connection with any Registration Statement hereunder. The Investor will as promptly as practicable
notify the Company of any material change in the information set forth in Exhibit A, other than changes in its ownership
of Common Stock.


 


(b)
Investor Cooperation. The Investor agrees to cooperate with the Company as reasonably requested by the Company in connection
with the preparation and filing of any amendments and supplements to any Registration Statement or New Registration Statement
hereunder.


 






    	6



    	 



    

 


5.
EXPENSES OF REGISTRATION.


 


All
reasonable expenses of the Company, other than sales or brokerage commissions and fees and disbursements of counsel for the Investor,
incurred in connection with registrations, filings or qualifications pursuant to Sections 2 and 3, including, without limitation,
all registration, listing and qualifications fees, printers and accounting fees, and fees and disbursements of counsel for the
Company, shall be paid by the Company.


 


6.
INDEMNIFICATION.


 


(a)
To the fullest extent permitted by law, the Company will, and hereby does, indemnify, hold harmless and defend the Investor, each
Person, if any, who controls the Investor, the members, the directors, officers, partners, employees, members, managers, agents,
representatives of the Investor and each Person, if any, who controls the Investor within the meaning of the Securities Act or
the Exchange Act (each, an “Indemnified Person”), against any third party losses, claims, damages, liabilities,
judgments, fines, penalties, charges, costs, reasonable attorneys’ fees, amounts paid in settlement (with the prior consent
of the Company, such consent not to be unreasonably withheld) or reasonable expenses, (collectively, “Claims”)
reasonably incurred in investigating, preparing or defending any action, claim, suit, inquiry, proceeding, investigation or appeal
taken from the foregoing by or before any court or governmental, administrative or other regulatory agency or body or the SEC,
whether pending or threatened, whether or not an indemnified party is or may be a party thereto (“Indemnified Damages”),
to which any of them may become subject insofar as such Claims (or actions or proceedings, whether commenced or threatened, in
respect thereof) arise out of or are based upon: (i) any untrue statement or alleged untrue statement of a material fact in the
Shelf Registration Statement, any New Registration Statement or any post-effective amendment thereto or in any filing made in
connection with the qualification of the offering under the securities or other “blue sky” laws of any jurisdiction
in which Registrable Securities are offered (“Blue Sky Filing”), or the omission or alleged omission to state
a material fact required to be stated therein or necessary to make the statements therein not misleading, (ii) any untrue statement
or alleged untrue statement of a material fact contained in the final Prospectus (as amended or supplemented, if the Company files
any amendment thereof or supplement thereto with the SEC) or the omission or alleged omission to state therein any material fact
necessary to make the statements made therein, in light of the circumstances under which the statements therein were made, not
misleading, or (iii) any violation or alleged violation by the Company of the Securities Act, the Exchange Act, any other law,
including, without limitation, any state securities law, or any rule or regulation thereunder relating to the offer or sale of
the Registrable Securities pursuant to the Shelf Registration Statement or any New Registration Statement (the matters in the
foregoing clauses (i) through (iii) being, collectively, “Violations”). The Company shall reimburse each Indemnified
Person promptly as such expenses are incurred and are due and payable, for any reasonable out-of-pocket legal fees or other reasonable
expenses incurred by them in connection with investigating or defending any such Claim. Notwithstanding anything to the contrary
contained herein, the indemnification agreement contained in this Section 6(a): (A) shall not apply to a Claim by an Indemnified
Person arising out of or based upon a Violation which occurs in reliance upon and in conformity with information furnished in
writing to the Company by the Investor or such Indemnified Person expressly for use in connection with the preparation of the
Registration Statement, any New Registration Statement, the Prospectus or any such amendment thereof or supplement thereto, if
such in each case if the foregoing was timely made available by the Company; (B) with respect to any superseded prospectus, shall
not inure to the benefit of any such Person from whom the Person asserting any such Claim purchased the Registrable Securities
that are the subject thereof (or to the benefit of any other Indemnified Person) if the untrue statement or omission of material
fact contained in the superseded prospectus was corrected in the revised prospectus, as then amended or supplemented, if such
revised prospectus was timely made available by the Company pursuant to Section 3(c) or Section 3(e), and the Indemnified Person
was promptly advised in writing not to use the incorrect prospectus prior to the use giving rise to a violation; (C) shall not
be available to the extent such Claim is based on a failure of the Investor to deliver, or to cause to be delivered, the prospectus
made available by the Company, if such prospectus was theretofore made available by the Company pursuant to Section 3(c) or Section
3(e); (D) shall not apply to amounts paid in settlement of any Claim if such settlement is effected without the prior written
consent of the Company, which consent shall not be unreasonably withheld; and (E) shall not apply to any Claims which directly
and primarily result from the fraud, gross negligence or willful misconduct of an Indemnified Person. Such indemnity shall remain
in full force and effect regardless of any investigation made by or on behalf of the Indemnified Person and shall survive the
transfer of the Registrable Securities by the Investor pursuant to Section 8.


 






    	7



    	 



    

 


(b)
In connection with the Shelf Registration Statement, any New Registration Statement or Prospectus, the Investor agrees to indemnify,
hold harmless and defend, to the same extent and in the same manner as is set forth in Section 6(a), the Company, each of its
directors, each of its officers who signed the Shelf Registration Statement or signs any New Registration Statement, each Person,
if any, who controls the Company within the meaning of the Securities Act or the Exchange Act (collectively and together with
an Indemnified Person, an “Indemnified Party”), against any Claim or Indemnified Damages to which any of them
may become subject, under the Securities Act, the Exchange Act or otherwise, insofar as such Claim or Indemnified Damages arise
out of or are based upon any Violation, in each case to the extent, and only to the extent, that such Violation occurs in reliance
upon and in conformity with written information about the Investor set forth on Exhibit A attached hereto or updated from time
to time in writing by the Investor and furnished to the Company by the Investor expressly for inclusion in the Shelf Registration
Statement or Prospectus or any New Registration Statement or from the failure of the Investor to deliver or to cause to be delivered
the prospectus made available by the Company, if such prospectus was timely made available by the Company pursuant to Section
3(c) or Section 3(e); and, subject to Section 6(d), the Investor will reimburse any reasonable out-of-pocket legal or other expenses
reasonably incurred by them in connection with investigating or defending any such Claim; provided, however, that
the indemnity agreement contained in this Section 6(b) and the agreement with respect to contribution contained in Section 7 shall
not apply to amounts paid in settlement of any Claim if such settlement is effected without the prior written consent of the Investor,
which consent shall not be unreasonably withheld; provided, further, however, that the Investor shall be
liable under this Section 6(b) for only that amount of a Claim or Indemnified Damages as does not exceed the net proceeds to the
Investor as a result of the sale of Registrable Securities pursuant to such Registration Statement. Such indemnity shall remain
in full force and effect regardless of any investigation made by or on behalf of such Indemnified Party and shall survive the
transfer of the Registrable Securities by the Investor pursuant to Section 8.


 


(c)
Promptly after receipt by an Indemnified Person or Indemnified Party under this Section 6 of notice of the commencement of any
action or proceeding (including any governmental action or proceeding) involving a Claim, such Indemnified Person or Indemnified
Party shall, if a Claim in respect thereof is to be made against any indemnifying party under this Section 6, deliver to the indemnifying
party a written notice of the commencement thereof, and the indemnifying party shall have the right to participate in, and, to
the extent the indemnifying party so desires, jointly with any other indemnifying party similarly noticed, to assume control of
the defense thereof with counsel mutually satisfactory to the indemnifying party and the Indemnified Person or the Indemnified
Party, as the case may be, and upon such notice, the indemnifying party shall not be liable to the Indemnified Person or Indemnified
Party for any legal or other expenses subsequently incurred by the Indemnified Person or Indemnified Party in connection with
the defense thereof; provided, however, that an Indemnified Person or Indemnified Party (together with all other
Indemnified Persons and Indemnified Parties that may be represented without conflict by one counsel) shall have the right to retain
its own counsel with the fees and expenses to be paid by the indemnifying party, if, in the reasonable opinion of counsel retained
by the indemnifying party, the representation by such counsel of the Indemnified Person or Indemnified Party and the indemnifying
party would be inappropriate due to actual or potential differing interests between such Indemnified Person or Indemnified Party
and any other party represented by such counsel in such proceeding. The Indemnified Party or Indemnified Person shall cooperate
with the indemnifying party in connection with any negotiation or defense of any such action or claim by the indemnifying party
and shall furnish to the indemnifying party all information reasonably available to the Indemnified Party or Indemnified Person
which relates to such action or claim. The indemnifying party shall keep the Indemnified Party or Indemnified Person fully apprised
as to the status of the defense or any settlement negotiations with respect thereto. No indemnifying party shall be liable for
any settlement of any action, claim or proceeding effected without its written consent, provided, however, that
the indemnifying party shall not unreasonably withhold, delay or condition its consent. No indemnifying party shall, without the
consent of the Indemnified Party or Indemnified Person, consent to entry of any judgment or enter into any settlement or other
compromise which does not include as an unconditional term thereof the giving by the claimant or plaintiff to such Indemnified
Party or Indemnified Person of a release from all liability in respect to such claim or litigation. Following indemnification
as provided for hereunder, the indemnifying party shall be subrogated to all rights of the Indemnified Party or Indemnified Person
with respect to all third parties, firms or corporations relating to the matter for which indemnification has been made. The failure
to deliver written notice to the indemnifying party within a reasonable time of the commencement of any such action shall not
relieve such indemnifying party of any liability to the Indemnified Person or Indemnified Party under this Section 6, except to
the extent that the indemnifying party is prejudiced in its ability to defend such action.


 






    	8



    	 



    

 


(d)
The indemnification required by this Section 6 shall be made by periodic payments of the amount thereof during the course of the
investigation or defense, as and when bills are received or Indemnified Damages are incurred. Any Person receiving a payment pursuant
to this Section 6 that is later determined not to be entitled to such payment shall return such payment (including reimbursement
of expenses) to the person making it.


 


(e)
The indemnity agreements contained herein shall be in addition to (i) any cause of action or similar right of the Indemnified
Party or Indemnified Person against the indemnifying party or others, and (ii) any liabilities the indemnifying party may be subject
to pursuant to the law.


 


7.
CONTRIBUTION.


 


To
the extent any indemnification by an indemnifying party is prohibited or limited by law, the indemnifying party agrees to make
the maximum contribution with respect to any amounts for which it would otherwise be liable under Section 6 to the fullest extent
permitted by law; provided, however, that: (i) no seller of Registrable Securities guilty of fraudulent misrepresentation
(within the meaning of Section 11(f) of the Securities Act) shall be entitled to contribution from any party who was not guilty
of fraudulent misrepresentation; and (ii) contribution by any seller of Registrable Securities shall be limited in amount to the
net amount of proceeds received by such seller from the sale of such Registrable Securities.


 


8.
ASSIGNMENT OF REGISTRATION RIGHTS.


 


The
Company shall not assign this Agreement or any rights or obligations hereunder without the prior written consent of the Investor;
provided, however, that any transaction, whether by merger, reorganization, restructuring, consolidation, financing
or otherwise, whereby the Company remains the surviving entity immediately after such transaction shall not be deemed an assignment.
The Investor may not assign its rights under this Agreement without the prior written consent of the Company, other than to an
affiliate of the Investor controlled by Fredric Zaino that becomes party to the Purchase Agreement, in which case the assignee
must agree in writing to be bound by the terms and conditions of this Agreement.


 






    	9



    	 



    

 


9.
AMENDMENT OF REGISTRATION RIGHTS.


 


No
provision of this Agreement may be (i) amended other than by a written instrument signed by both parties hereto or (ii) waived
other than in a written instrument signed by the party against whom enforcement of such waiver is sought. Failure of any party
to exercise any right or remedy under this Agreement or otherwise, or delay by a party in exercising such right or remedy, shall
not operate as a waiver thereof.


 


10.
MISCELLANEOUS.


 


(a)
Notices. Any notices, consents or other communications required or permitted to be given under the terms of this Agreement
must be in writing and will be deemed to have been delivered: (i) upon receipt, when delivered personally; (ii) upon receipt,
when sent by facsimile (provided confirmation of transmission is mechanically or electronically generated and kept on file by
the sending party); (iii) upon receipt, when sent by electronic message (provided the recipient responds to the message and confirmation
of both electronic messages are kept on file by the sending party); or (iv) one (1) Business Day after timely deposit with a nationally
recognized overnight delivery service, in each case properly addressed to the party to receive the same. The addresses and facsimile
numbers for such communications shall be:


 


If
to the Company:


 


PolarityTE,
Inc.

123 Wright Brothers Drive

Salt Lake City, UT 84116

Telephone: (800) 560-3983

E-mail: davidseaburg@polarityte.com

Attention: Mr. David Seaburg, President


 


With
a copy to (which shall not constitute notice or service of process):


 


King
& Spalding LLP

601 South California Avenue

Palo Alto, CA 94304

Telephone: (650) 422-6713

E-mail: lbushnell@kslaw.com

Attention: Laura I. Bushnell, Esq.


 


If
to the Investor:


 


Keystone
Capital Partners, LLC

139 Fulton Street, Suite 412

New York, NY 10038

Telephone: (646) 349-0916

E-mail: fz@keystone-cp.com

Attention: Mr. Fredric G. Zaino


 






    	10



    	 



    

 


With
a copy to (which shall not constitute notice or service of process):


 


Olshan
Frome Wolosky LLP

1325 Avenue of the Americas, 15th Floor

New York, New York 10019

Telephone: (212) 451-2300

Facsimile: (212) 451-2222

E-mail: sfeldman@olshanlaw.com

Attention: Spencer G. Feldman, Esq.


 


or
at such other address, e-mail address and/or facsimile number and/or to the attention of such other person as the recipient party
has specified by written notice given to each other party at least one (1) Business Day prior to the effectiveness of such change.
Written confirmation of receipt (A) given by the recipient of such notice, consent or other communication, (B) mechanically or
electronically generated by the sender’s facsimile machine containing the time, date, and recipient facsimile number, (C)
electronically generated by the sender’s electronic mail containing the time, date and recipient email address or (D) provided
by a nationally recognized overnight delivery service, shall be rebuttable evidence of receipt in accordance with clause (i),
(ii), (iii) or (iv) above, respectively. Any party to this Agreement may give any notice or other communication hereunder using
any other means (including messenger service, ordinary mail or electronic mail), but no such notice or other communication shall
be deemed to have been duly given unless it actually is received by the party for whom it is intended.


 


(b)
No Waiver. No failure or delay in the exercise of any power, right or privilege hereunder shall operate as a waiver thereof,
nor shall any single or partial exercise of any such power, right or privilege preclude other or further exercise thereof or of
any other right, power or privilege.


 


(c)
Governing Law. All questions concerning the construction, validity, enforcement and interpretation of this Agreement shall
be governed by the internal laws of the State of New York, without giving effect to any choice of law or conflict of law provision
or rule (whether of the State of New York or any other jurisdictions) that would cause the application of the laws of any jurisdictions
other than the State of New York. Each party hereby irrevocably submits to the exclusive jurisdiction of and venue in the U.S.
District Court for the Southern District of New York or, if that court does not have subject matter jurisdiction, in any state
court located in The City and County of New York, for the adjudication of any dispute hereunder or in connection herewith or with
any transaction contemplated hereby or discussed herein, and hereby irrevocably waives, and agrees not to assert in any suit,
action or proceeding, any claim that it is not personally subject to the jurisdiction of any such court, that such suit, action
or proceeding is brought in an inconvenient forum or that the venue of such suit, action or proceeding is improper. Each party
hereby irrevocably waives personal service of process and consents to process being served in any such suit, action or proceeding
by mailing a copy thereof to such party at the address for such notices to it under this Agreement and agrees that such service
shall constitute good and sufficient service of process and notice thereof. Nothing contained herein shall be deemed to limit
in any way any right to serve process in any manner permitted by law. If any provision of this Agreement shall be invalid or unenforceable
in any jurisdiction, such invalidity or unenforceability shall not affect the validity or enforceability of the remainder of this
Agreement in that jurisdiction or the validity or enforceability of any provision of this Agreement in any other jurisdiction.
EACH PARTY HEREBY IRREVOCABLY WAIVES ANY RIGHT IT MAY HAVE, AND AGREES NOT TO REQUEST, A JURY TRIAL FOR THE ADJUDICATION OF
ANY DISPUTE HEREUNDER OR IN CONNECTION HEREWITH OR ARISING OUT OF THIS AGREEMENT OR ANY TRANSACTION CONTEMPLATED HEREBY.


 


(d)
Integration. This Agreement, the Purchase Agreement and the other Transaction Documents constitute the entire understanding
among the parties hereto with respect to the subject matter hereof and thereof. There are no restrictions, promises, warranties
or undertakings, other than those set forth or referred to herein and therein. This Agreement, the Purchase Agreement and the
other Transaction Documents supersede all other prior oral or written agreements between the Investor, the Company, their affiliates
and persons acting on their behalf with respect to the subject matter hereof and thereof.


 






    	11



    	 



    

 


(e)
No Third-Party Benefits. Subject to the requirements of Section 8, this Agreement shall inure to the benefit of and be
binding upon the permitted successors and assigns of each of the parties hereto.


 


(f)
Headings. The headings in this Agreement are for convenience of reference and shall not form part of, or affect the interpretation
of, this Agreement.


 


(g)
Counterparts. This Agreement may be executed in two or more identical counterparts, all of which shall be considered one
and the same agreement and shall become effective when counterparts have been signed by each party and delivered to the other
party; provided that a facsimile or pdf (or other electronic reproduction of a) signature shall be considered due execution
and shall be binding upon the signatory thereto with the same force and effect as if the signature were an original, not a facsimile
or pdf (or other electronic reproduction of a) signature.


 


(h)
Each party shall do and perform, or cause to be done and performed, all such further acts and things, and shall execute and deliver
all such other agreements, certificates, instruments and documents as the other party may reasonably request in order to carry
out the intent and accomplish the purposes of this Agreement and the consummation of the transactions contemplated hereby.


 


(i)
The language used in this Agreement will be deemed to be the language chosen by the parties to express their mutual intent and
no rules of strict construction will be applied against any party.


 


(j)
This Agreement is intended for the benefit of the parties hereto and their respective permitted successors and assigns, and is
not for the benefit of, nor may any provision hereof be enforced by, any other Person.


 


(k)
Termination. The obligations of the Company contained in Sections 2, 3, 5 and 8 of this Agreement shall terminate in their
entirety upon the expiration of the Registration Period.


 


* 
*  *  *  *


 









    	12



    	 



    

 


IN
WITNESS WHEREOF, the parties have caused this Registration Rights Agreement to be duly executed as of day and year first above
written.


 


	THE
    COMPANY:	 
	 	 
	POLARITYTE,
    INC.	 
	 	 
	By:	/s/
    David Seaburg	 
	Name:	David
    Seaburg	 
	Title:	President	 


 


	INVESTOR:	 
	 	 
	KEYSTONE
    CAPITAL PARTNERS, LLC	 
	By:
    RANZ Group, LLC, Manager	 
	 	 
	By:	/s/
    Fredric G. Zaino	 
	Name:	Fredric
    G. Zaino 	 
	Title:	Managing
    Member	 


 


[Signature
Page to Registration Rights Agreement]







 






    	13



    	 



    

 


EXHIBIT
A


 


Information
about the Investor furnished to the Company by the Investor

expressly for use in connection with prospectus


 


Information
with respect to Keystone Capital Partners, LLC


 


Immediately
prior to the date of the Purchase Agreement, Keystone Capital Partners, LLC (“Keystone Capital”) beneficially owned
no shares of Common Stock. Frederic G. Zaino, the Managing Member of RANZ Group, LLC (“RANZ”), the manager of Keystone
Capital, is deemed to be the beneficial owner of all of the Common Stock owned by Keystone Capital. Mr. Zaino, through RANZ, has
sole voting and investment power over the shares being offered under the prospectus supplement filed with the SEC in connection
with the transactions contemplated under the Purchase Agreement. Keystone Capital is not a licensed broker-dealer or an affiliate
of a licensed broker-dealer.


 


Plan
of Distribution


 


Keystone
is an “underwriter” within the meaning of Section 2(a)(11) of the Securities Act. Keystone has informed us that it
will use an unaffiliated broker-dealer to effectuate all sales, if any, of the common stock that it may purchase from us pursuant
to the Purchase Agreement. Such sales will be made on The Nasdaq Capital Market at prices and at terms then prevailing or at prices
related to the then current market price. Each such unaffiliated broker-dealer will be an underwriter within the meaning of Section
2(a)(11) of the Securities Act. Keystone has informed us that each such broker-dealer will receive commissions from Keystone that
will not exceed customary brokerage commissions.


 


Keystone
represented to us that at no time prior to the date of the Purchase Agreement has Keystone or its agents, representatives or affiliates
engaged in or effected, in any manner whatsoever, directly or indirectly, any short sale (as such term is defined in Rule 200
of Regulation SHO of the Exchange Act) of our common stock or any hedging transaction that establishes a net short position in
our common stock. Keystone agreed that during the term of the Purchase Agreement, it, its agents, representatives or affiliates
will not enter into or effect, directly or indirectly, any of the foregoing transactions.


 






    	14