EX-4.4





 Exhibit 4.4 

BY-LAW NO. 3 

ADVANCE NOTICE BY-LAW 

(Adopted by the Board of Directors of the Corporation with immediate effect on March 23, 2016)  

A by-law relating to the advance notice of nominations of directors of 

LIMINAL BIOSCIENCES INC. 

(hereinafter referred to as the “Corporation”)  

 
  

INTRODUCTION 
 The purpose of this Advance Notice By-Law (the “By-Law”) is to provide shareholders, directors and management of the Corporation with a clear framework for nominating directors. This By-Law fixes a deadline by which registered or beneficial owners of the common shares of the Corporation must submit director nominations to the Corporation prior to any annual or special meeting of shareholders
called for any purpose of which the election of directors is a matter specified in the notice of meeting, and sets forth the information to be provided and other procedures to be followed, in respect of such nomination. 

It is the position of the Corporation that this By-Law is in the best interests of the Corporation. This policy will
be subject to periodic review, and subject to the Act (as defined below), will reflect changes as required by securities regulatory authorities or stock exchanges and, at the discretion of the Board, amendments necessary to meet evolving industry
standards. 
 Article 1 

NOMINATION OF DIRECTORS 

Section 1.1    Subject only to the Canada Business Corporations Act (the “Act”), applicable securities laws
and the articles of the Corporation, only persons who are nominated in accordance with the procedures set out in this By-Law shall be eligible for election as directors to the board of directors (the
“Board”) of the Corporation. Nominations of persons for election to the Board may only be made at an annual meeting of shareholders, or at a special meeting of shareholders called for any purpose at which the election of directors
is a matter specified in the notice of meeting, as follows: 
  

	 	(a)	 by or at the direction of the Board or an authorized officer of the Corporation, including pursuant to a notice
of meeting; 


  

	 	(b)	 by or at the direction or request of one or more shareholders pursuant to a proposal made in accordance with
Section 137 of the Act or a requisition of shareholders made in accordance with Section 143 of the Act, as such provisions may be amended from time to time; or 



 

	 	(c)	 by any person entitled to vote at such meeting (a “Nominating Shareholder”), who: (A) is,
at the close of business on the date of giving notice provided for in Section 1.3 below and on the record date for notice of such meeting, either entered in the securities register of the Corporation as a holder of one or more shares carrying
the right to vote at such meeting or who beneficially owns shares that are entitled to be voted at such meeting; and (B) has given timely notice in proper written form as set forth in this By-Law.



 Section 1.2    For the avoidance of doubt, the foregoing Section 1.1 shall be the exclusive means for any
person to bring nominations for election to the Board before any annual or special meeting of shareholders of the Corporation. 












 Section 1.3    In addition to any other applicable requirement, for a nomination
made by a Nominating Shareholder to be timely notice (a “Timely Notice”), the Nominating Shareholder’s notice must be received by the corporate secretary of the Corporation at the principal executive offices of the
Corporation: 
  

	 	(a)	 in the case of an annual meeting of shareholders (including an annual and special meeting), not later than the
close of business on the thirtieth 30th day; provided, however, if the date (the “Notice Date”) on which the first public announcement made by the Corporation of the date of the
annual meeting is less than 50 days prior to the meeting date, not later than the close of business on the 10th day following the Notice Date; 



 

	 	(b)	 in the case of a special meeting (which is not also an annual meeting) of shareholders called for any purpose
which includes the election of directors to the Board, not later than the close of business on the 15th day following the day on which the first public announcement of the date of the special
meeting is made by the Corporation; 


 Section 1.4    To be in proper written form, a Nominating
Shareholder’s notice to the corporate secretary must comply with this Section and disclose or include, as applicable: 
  

	 	(a)	 as to each person whom the Nominating Shareholder proposes to nominate for election as a director (a
“Proposed Nominee”): 


  

	 	(i)	 their name, age, business and residential address; 



 

	 	(ii)	 the principal occupation, business or employment both presently and for the past five years;



  

	 	(iii)	 whether the Proposed Nominee is a “resident Canadian” within the meaning of the Act;



  

	 	(iv)	 the number of securities of each class of voting securities of the Corporation or any of its subsidiaries
beneficially owned, or controlled or directed, directly or indirectly, by the Proposed Nominee, as of the record date for the meeting of shareholders (if such date shall then have been made publicly available and shall have occurred) and as of the
date of such notice; 


  

	 	(v)	 a description of any relationships, agreements, arrangements, or understandings (including financial,
compensation or indemnity related) between the Proposed Nominee or any affiliates or associates of, or any person or entity acting jointly or in concert with, the Proposed Nominee or the Nominating Shareholder, in connection with the Proposed
Nominee’s nomination and election as director; and 


  

	 	(vi)	 any other information that would be required to be disclosed in a dissident proxy circular or other filings
required to be made in connection with the solicitation of proxies for election of directors pursuant to the Act or applicable securities law; 


  

	 	(b)	 as to each Nominating Shareholder giving the notice and each beneficial owner, if any, on whose behalf the
nomination is made: 


  

	 	(i)	 their name, business and residential address; 















	 	(ii)	 the number of securities of each class of voting securities of the Corporation or any of its subsidiaries
beneficially owned, or controlled or directed, directly or indirectly, by the Nominating Shareholder or any other person with whom the Nominating Shareholder is acting jointly or in concert with respect to the Corporation or any of its securities,
as of the record date for the meeting of shareholders (if such date shall then have been made publicly available and shall have occurred) and as of the date of such notice; 



 

	 	(iii)	 their interests in, or rights or obligations associated with, any agreement, arrangement or understanding, the
purpose or effect of which is to alter, directly or indirectly, the person’s economic interest in a security of the Corporation or the person’s economic exposure to the Corporation; 



 

	 	(iv)	 full particulars of any proxy, contract, arrangement, agreement or understanding pursuant to which such person,
or any of its affiliates or associates, or any person acting jointly or in concert with such person, has any interests, rights or obligations relating to the voting of any securities of the Corporation or the nomination of directors to the Board;



  

	 	(v)	 a representation and evidence that the Nominating Shareholder is a holder of record of securities of the
Corporation, or a beneficial owner, entitled to vote at such meeting, and intends to appear in person or by proxy at the meeting to propose such nomination; and 



 

	 	(vi)	 any other information relating to such person that would be required to be included in a dissident proxy
circular or other filings required to be made in connection with solicitations of proxies for election of directors pursuant to the Act or as required by applicable securities law; 



Reference to “Nominating Shareholder” in this Section 1.4 shall be deemed to refer to each shareholder that nominated or seeks to nominate a
person for election as director in the case of a nomination proposal where more than one shareholder is involved in making the nomination proposal. 

Section 1.5    If requested by the Corporation, the Nominating Shareholder shall update such information forthwith so that it is true
and correct as of the date that is ten (10) business days prior to the date of the meeting, or any adjournment or postponement thereof. 

Section 1.6    Any notice, or other document or information required to be given to the corporate secretary pursuant to this By-Law may only be given by personal delivery, facsimile transmission or by email (at such email address as may be stipulated from time to time by the corporate secretary for purposes of this notice), and shall be
deemed to have been received only at the time it is served by personal delivery to the corporate secretary at the address of the principal executive offices of the Corporation, email (at the address as aforesaid) or sent by facsimile transmission
(provided that receipt of confirmation of such transmission has been received); provided that if such delivery or electronic communication is made on a day which is a not a business day or later than 5:00 p.m. (Toronto time) on a day which is a
business day, then such delivery or electronic communication shall be deemed to have been made on the next following day that is a business day. 

Section 1.7    Additional Matters 
  

	(1)	 The chair of any meeting of shareholders of the Corporation shall have the power to determine whether any
proposed nomination is made in accordance with the provisions of this By-Law, and if any proposed nomination is not in compliance with such provisions, must declare that such defective nomination shall not be
considered at any meeting of shareholders. 















	(2)	 The Board may, in its sole discretion, waive any requirement of this
By-Law. 


  

	(3)	 For the purposes of this By-Law, “public announcement” means
disclosure in a press release disseminated by the Corporation through a national news service in Canada, or in a document filed by the Corporation for public access under its profile on the System of Electronic Document Analysis and Retrieval
(SEDAR) at www.sedar.com. 


  

	(4)	 This By-Law is subject to, and should be read in conjunction with, the
Act and the articles. If there is any conflict or inconsistency between any provision of the Act or the articles and any provision of this By-Law, the provision of the Act or the articles will govern.



 Article 2 

ANNUAL OR SPECIAL MEETINGS OF SHAREHOLDERS 

Section 2.1    No business may be transacted at an annual or special meeting of shareholders other than business that
is either (i) specified in the Corporation’s notice of meeting (or any supplement thereto) given by or at the direction of the Board, (ii) otherwise properly brought before the meeting by or at the direction of the Board, or
(iii) otherwise properly brought before the meeting by any shareholder of the Corporation who complies with the proposal procedures set forth in Section 2.2 below. 

Section 2.2    For business to be properly brought before a meeting by a shareholder of the Corporation, such shareholder must submit
a proposal to the Corporation for inclusion in the Corporation’s management proxy circular in accordance with the requirements of the Act; provided that any proposal that includes nominations for the election of directors shall also comply with
the requirements of Article 1.