Exhibit 21

ST. JUDE MEDICAL, INC. 
SUBSIDIARIES OF THE REGISTRANT
as of January 3, 2009

|                                                   |                                                                                                                                                            |                                                                            |                                                                                      |                                                                                                  
|-------------------------------------------------- | ---------------------------------------------------------------------------------------------------------------------------------------------------------- | -------------------------------------------------------------------------- | ------------------------------------------------------------------------------------ | -------------------------------------------------------------------------------------------------
|St. Jude
 Medical, Inc. Wholly Owned Subsidiaries:
|                                                  | MediGuide,
 Inc. (Delaware corporation)                                                                                                                   
|                                                   | -                                                                                                                                                          | MediGuide
 Ltd. (Israeli corporation)                                     
|                                                  | Pacesetter,
 Inc. - Sylmar, California, Scottsdale, Arizona, and Maven, South Carolina                                                                    
|                                                   | (Delaware
 corporation) (dba St. Jude Medical Cardiac Rhythm Management Division)                                                                         
|                                                  | St. Jude
 Medical S.C., Inc.  Austin, Texas (Minnesota corporation)                                                                                      
|                                                   | -                                                                                                                                                          | San Diego
 Pace, Inc. (California corporation)                            
|                                                  | St. Jude
 Medical Europe, Inc. - St. Paul, Minnesota (Delaware corporation)                                                                               
|                                                   | -                                                                                                                                                          | Brussels,
 Belgium branch                                                 
|                                                  | St. Jude
 Medical Canada, Inc. - Mississauga, Ontario and St. Hyacinthe, Quebec                                                                           
|                                                   | (Ontario,
 Canada corporation)                                                                                                                            
|                                                  | St. Jude
 Medical (Shanghai) Co., Ltd.  Shanghai, China (Chinese corporation)                                                                            
|                                                   | -                                                                                                                                                          | Beijing,
 Shanghai and Guangzhou representative offices                   
|                                                  | St. Jude
 Medical Australia Pty., Ltd.  Sydney, Australia (Australian corporation)                                                                       
|                                                  | St. Jude
 Medical Brasil, Ltda. - Sao Paulo and Belo Horizonte, Brazil (Brazilian
 corporation)                                                           
|                                                  | St. Jude
 Medical, Atrial Fibrillation Division, Inc. (Formerly St. Jude Medical, Daig
 Division, Inc.) - Minnesota and California (Minnesota corporation)
|                                                   | -                                                                                                                                                          | Endocardial
 Solutions NV/SA (Belgian Corporation)                        
|                                                   | -                                                                                                                                                          | EP
 MedSystems LLC (Minnesota Limited Liability Company)                  
|                                                   |                                                                                                                                                            | -                                                                          | ProCath
 Corporation (New Jersey corporation)                                       
|                                                   |                                                                                                                                                            | -                                                                          | EP
 MedSystems U.K. Ltd., (New Jersey corporation) (dba EP MedSystems, Europe
 Ltd.)
|                                                   |                                                                                                                                                            |                                                                            | -                                                                                    | EP
 MedSystems France. (French corporation) (wholly owned subsidiary of EP
 MedSystems U.K. Ltd.)
|                                                  | St. Jude Medical Colombia, Ltda. - Bogota, Colombia (Colombian
 corporation)                                                                              
|                                                  | St. Jude
 Medical ATG, Inc. - Maple Grove, Minnesota (Minnesota corporation) (Shell)                                                                      
|                                                  | St. Jude
 Medical (Thailand) Co., Ltd.  Bangkok, Thailand (Thai corporation)                                                                             
|                                                  | Irvine
 Biomedical, Inc.  Irvine, California (California corporation)                                                                                    
|                                                  | St. Jude
 Medical, Cardiology Division, Inc. (Formerly Velocimed, Inc.) - Minnesota
 (Delaware corporation) (dba St. Jude Medical Cardiovascular Division)
|                                                  | SJ Medical Mexico, S. de R.L. de C.V. (Mexican corporation)                                                                                               
|                                                  | St. Jude
 Medical Argentina S.A.  Buenos Aires, Argentina (Argentinean corporation)                                                                      
|                                                  | Advanced
 Neuromodulation Systems, Inc.  Plano, Texas (Texas Corporation) (dba St.
 Jude Medical Neuromodulation Division)                               
|                                                   | -                                                                                                                                                          | Hi-Tronics
 Designs, Inc.  Budd Lake, New Jersey (New Jersey Corporation)
|                                                   | -                                                                                                                                                          | Advanced
 Neuromodulation Systems, UK Limited (United Kingdom corporation)
|                                                  | SJM
 International, Inc. - St. Paul, Minnesota (Delaware corporation)                                                                                     
|                                                   | -                                                                                                                                                          | Tokyo, Japan
 branch                                                      

|                                                                                |                                                                                                                                                            |                                                                        |                                                                                                                                         |                                                |                                                        
|------------------------------------------------------------------------------- | ---------------------------------------------------------------------------------------------------------------------------------------------------------- | ---------------------------------------------------------------------- | --------------------------------------------------------------------------------------------------------------------------------------- | ---------------------------------------------- | -------------------------------------------------------
|SJM
 International, Inc. Wholly Owned Legal Entities (Directly and Indirectly):
|                                                                               | SJM Delaware
 Holding, LLC - St. Paul, Minnesota (Delaware Limited Liability Company)                                                                     
|                                                                               | St. Jude
 Medical Bermuda GP (Bermuda partnership) (SJM International, Inc. is the
 majority partner and SJM Delaware Holding LLC is the minority partner)
|                                                                                | -                                                                                                                                                          | St. Jude
 Medical Luxembourg Holding S.à r.l. (Luxembourg corporation)
|                                                                                |                                                                                                                                                            | -                                                                      | St. Jude
 Medical Nederland B.V. (Netherlands corporation) (wholly owned subsidiary of
 St. Jude Medical Luxembourg Holding S.à r.l.)  
|                                                                                |                                                                                                                                                            | -                                                                      | St. Jude
 Medical Puerto Rico LLC (Puerto Rican corporation) (wholly owned subsidiary
 of St. Jude Medical Luxembourg Holding S.à r.l.)
|                                                                                |                                                                                                                                                            | -                                                                      | St. Jude
 Medical AB (Swedish corporation) (wholly owned subsidiary of St. Jude Medical
 Luxembourg Holding S.à r.l.)                  
|                                                                                |                                                                                                                                                            |                                                                        | -                                                                                                                                       | Radi Medical
 Systems AB (Swedish corporation)
|                                                                                |                                                                                                                                                            |                                                                        |                                                                                                                                         | -                                              | Radi Medical
 Systems, Inc. (US corporation)           
|                                                                                |                                                                                                                                                            |                                                                        |                                                                                                                                         | -                                              | Radi Medical
 Systems GmbH (German corporation)        
|                                                                                |                                                                                                                                                            |                                                                        |                                                                                                                                         | -                                              | Radi Medical
 Systems Ltd. (United Kingdom corporation)
|                                                                                |                                                                                                                                                            |                                                                        |                                                                                                                                         | -                                              | Radi Medical
 Systems B.V. (Dutch corporation)         

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|  |                                                                                                |   |                                                                                                                                                      |                                                                                                                                   |                                                                          
|- | ---------------------------------------------------------------------------------------------- | - | ---------------------------------------------------------------------------------------------------------------------------------------------------- | --------------------------------------------------------------------------------------------------------------------------------- | -------------------------------------------------------------------------
|  |                                                                                                |   |                                                                                                                                                      | -                                                                                                                                 | Radi Medical
 Systems Pty. Ltd. (Australian corporation)                 
|  |                                                                                                |   |                                                                                                                                                      | -                                                                                                                                 | Radi Medical
 Systems KK (Japanese corporation)                          
|  |                                                                                                |   |                                                                                                                                                      | -                                                                                                                                 | Radi Medical
 Systems Co., Ltd. (Thai corporation)                       
|  |                                                                                                |   |                                                                                                                                                      | -                                                                                                                                 | Radi Medical
 Systems s.a.s. (French corporation)                        
|  |                                                                                                |   |                                                                                                                                                      | -                                                                                                                                 | Radi Medical
 Systems Pte., Ltd. (Singaporean corporation)               
|  |                                                                                                |   |                                                                                                                                                      | -                                                                                                                                 | Beijing,
 China representative office                                    
|  |                                                                                                |   | -                                                                                                                                                    | HB
 Betakonsult (Swedish partnership) (St. Jude Medical AB holds a 99% interest
 and Radi Medical Systems AB holds a 1% interest)
|  |                                                                                                | - | SJM
 Coordination Center BVBA (Belgian corporation) (wholly owned subsidiary of
 St. Jude Medical Luxembourg S.à r.l.)                              
|  |                                                                                                |   | -                                                                                                                                                    | Cardio Life
 Research S.A. (Belgian corporation)                                                                                 
|  |                                                                                                | - | St. Jude
 Medical Operations (Malaysia) Sdn. Bhd. (Malaysian corporation) (wholly owned
 subsidiary of St. Jude Medical Luxembourg Holding S.à r.l.)
|  |                                                                                                | - | St. Jude
 Medical Costa Rica Limitada (Costa Rica corporation) (wholly owned subsidiary
 of St. Jude Medical Luxembourg Holding S.à r.l.)           
|  |                                                                                                | - | St. Jude
 Medical Holdings B.V. (Netherlands corporation) (wholly owned subsidiary of
 St. Jude Medical Luxembourg Holding S.à r.l.)                
|  |                                                                                                |   | -                                                                                                                                                    | St. Jude
 Medical Japan Co., Ltd. (Japanese corporation) (wholly owned subsidiary of
 St. Jude Medical Holdings B.V.)            
|  |                                                                                                |   | -                                                                                                                                                    | St. Jude
 Medical India Private Limited (Indian corporation) (wholly owned subsidiary
 of St. Jude Medical Holdings B.V.)        
|  |                                                                                                |   | -                                                                                                                                                    | St. Jude
 Medical (Singapore) Pte. Ltd. (Singaporean corporation) (wholly owned
 subsidiary of St. Jude Medical Holdings B.V.)   
|  |                                                                                                |   | -                                                                                                                                                    | St. Jude
 Medical (Malaysia) Sdn Bhd (Malaysian corporation) (wholly owned subsidiary
 of St. Jude Medical Holdings B.V.)        
|  |                                                                                                |   | -                                                                                                                                                    | St. Jude
 Medical Taiwan Co. (Taiwan corporation) (wholly owned subsidiary of St. Jude
 Medical Holdings B.V.)                   
|  |                                                                                                |   | -                                                                                                                                                    | St. Jude
 Medical Korea YH (Korean corporation) (wholly owned subsidiary of St. Jude
 Medical Holdings B.V.                      
|  |                                                                                                |   | -                                                                                                                                                    | St. Jude
 Medical (Hong Kong) Limited - Central, Hong Kong (Hong Kong corporation)                                               
|  |                                                                                                |   |                                                                                                                                                      | -                                                                                                                                 | Mumbai, New
 Delhi, Calcutta, Chennai and Bangalore, India branch offices
| | St. Jude
 Medical Sweden AB (Swedish corporation)                                             
| | St. Jude
 Medical Danmark A/S (Danish corporation)                                            
| | St. Jude Medical (Portugal) - Distribuição de Produtos Médicos, Lda. (Portuguese
 corporation)
| | St. Jude
 Medical Export Ges.m.b.H. (Austrian corporation)                                    
| | St. Jude
 Medical Medizintechnik Ges.m.b.H. (Austrian corporation)                            
| | St. Jude Medical
 Italia S.p.A. (Italian corporation)                                         
| | St. Jude
 Medical Belgium (Belgian corporation)                                               
| | St. Jude
 Medical España S.A. (Spanish corporation)                                           
| | St. Jude
 Medical France S.A.S. (French corporation)                                          
| | St. Jude
 Medical Finland O/y (Finnish corporation)                                           
| | St. Jude
 Medical Sp.zo.o. (Polish corporation)                                               
| | St. Jude
 Medical GmbH (German corporation)                                                   
| | St. Jude
 Medical Kft (Hungarian corporation)                                                 
| | St. Jude
 Medical UK Limited (United Kingdom corporation)                                     
| | St. Jude
 Medical (Schweiz) AG (Swiss corporation)                                            
| | UAB St.
 Jude Medical Baltic (Lithuanian corporation)                                       
| | St. Jude
 Medical Norway AS (Norwegian corporation)                                           

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