Exhibit 4.2


 


EXECUTION VERSION


 


ABBVIE INC.


 


SUPPLEMENTAL INDENTURE NO. 7


 


$750,000,000 Senior Floating
Rate Notes due May 2021


$750,000,000 Senior Floating
Rate Notes due November 2021


$750,000,000 Senior Floating
Rate Notes due 2022


$1,750,000,000 2.150%
Senior Notes due 2021


$3,000,000,000 2.300%
Senior Notes due 2022


$3,750,000,000 2.600%
Senior Notes due 2024


$4,000,000,000 2.950%
Senior Notes due 2026


$5,500,000,000 3.200%
Senior Notes due 2029


$4,000,000,000 4.050%
Senior Notes due 2039


$5,750,000,000 4.250%
Senior Notes due 2049


 


THIS SUPPLEMENTAL INDENTURE NO. 7, dated
as of November 21, 2019 (the “Supplemental Indenture”), among ABBVIE INC., a Delaware corporation (the “Company”),
and U.S. BANK NATIONAL ASSOCIATION, a national banking association, as trustee (the “Trustee”).


 


RECITALS OF THE COMPANY:


 


WHEREAS, the Company has heretofore executed
and delivered to the Trustee an Indenture, dated as of November 8, 2012 (as heretofore supplemented or amended, the “Indenture”),
providing for the issuance from time to time of one or more series of Securities (as defined in the Indenture);


 


WHEREAS, the Company has entered into a
definitive transaction agreement, dated as of June 25, 2019, by and among the Company, Allergan plc, an Irish public limited company
(“Allergan”), and Venice Subsidiary LLC, a wholly owned subsidiary of the Company (“Acquiror Sub”),
as amended from time to time, which provides, among other things, that on the terms and subject to conditions set forth therein,
Acquiror Sub will acquire Allergan, with Allergan surviving as a wholly-owned subsidiary of the Company (the “Acquisition”);


 


WHEREAS, Article Nine of the Indenture
provides for various matters with respect to any series of Securities issued under the Indenture to be established in an indenture
supplemental to the Indenture;


 


WHEREAS, Section 9.1(7) of the
Indenture provides that the Company and the Trustee may enter into an indenture supplemental to the Indenture to establish the
form or terms of Securities of any series as permitted by Sections 2.1 and 3.1 of the Indenture;


 


WHEREAS, Section 9.1 of the Indenture provides
that the Company and the Trustee may modify certain terms of the Indenture and provide certain additional provisions with respect
to any series of Securities to be issued under the Indenture; and


 






     


     


    

 


WHEREAS, all the conditions and requirements
necessary to make this Supplemental Indenture, when duly executed and delivered, a valid and binding agreement in accordance with
its terms and for the purposes herein expressed, have been performed and fulfilled.


 


NOW THEREFORE, THIS SUPPLEMENTAL INDENTURE
WITNESSETH:


 


For and in consideration of the premises
and the issuance of the series of Securities provided for herein, the Company and the Trustee mutually covenant and agree for the
equal and proportionate benefit of the respective Holders of the Securities of each such series as follows:


 


Article 1


RELATION TO INDENTURE; DEFINITIONS; RULES OF CONSTRUCTION


 


Section 1.1.          
Relation to Indenture.  This Supplemental Indenture constitutes an integral part of the Indenture.


 


Section 1.2.          
Definitions.  For all purposes of this Supplemental Indenture, the following terms shall have the respective meanings
set forth in this Section.


 


“2021 Notes”
means the 2.150% Senior Notes due 2021.


 


“2022 Floating
Rate Notes” means the Senior Floating Rate Notes due 2022.


 


“2022 Notes”
means the 2.300% Senior Notes due 2022.


 


“2024 Notes”
means the 2.600% Senior Notes due 2024.


 


“2026 Notes”
means the 2.950% Senior Notes due 2026.


 


“2029 Notes”
means the 3.200% Senior Notes due 2029.


 


“2039 Notes”
means the 4.050% Senior Notes due 2039.


 


“2049 Notes”
means the 4.250% Senior Notes due 2049.


 


“Applicable Debt”
of any Person means, without duplication, (a) all indebtedness of such Person for borrowed money, (b) all obligations of such
Person for the deferred purchase price of property or services (other than trade payables incurred in the ordinary course of
such Person’s business and other than any earn-out obligation until after such obligation becomes due and payable), (c)
all obligations of such Person evidenced by notes, bonds, debentures or other similar instruments, (d) all obligations of
such Person created or arising under any conditional sale or other title retention agreement with respect to property
acquired by such Person (even though the rights and remedies of the seller or lender under such agreement in the event of
default are limited to repossession or sale of such property), (e) all obligations of such Person as lessee under leases that
are or should be, in accordance with GAAP, recorded as capital leases; provided, however, that, all obligations
of any Person that were or would be characterized as operating lease obligations in accordance with GAAP on August 31, 2018
(whether or not such operating lease obligations were in effect on such date) shall, if so elected by the Company, continue
to be accounted for as operating lease obligations (and not a capital lease) for purposes of the indenture regardless of any
change in GAAP following such date that would otherwise require such obligations to be characterized or recharacterized (or a
prospective or retroactive basis or otherwise) as capital leases, (f) all obligations, contingent or otherwise, of such
Person in respect of acceptances, letters of credit or similar extensions of credit, (g) all obligations of such Person in
respect of Hedge Agreements, (h) all Applicable Debt of others referred to in clauses (a) through (g) above or clause (i)
below directly guaranteed in any manner by such Person, or the payment of which is otherwise provided for by such Person, and
(i) all Applicable Debt referred to in clauses (a) through (h) above secured by any Lien on property (including, without
limitation, accounts and contract rights) owned by such Person, even though such Person has not assumed or become liable for
the payment of such Applicable Debt.


 






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“Applicable Procedures”
means, with respect to any transfer or transaction involving a Regulation S Global Note or beneficial interest therein, the
rules and procedures of the Depository for such Global Note, Euroclear and Clearstream, in each case to the extent applicable to
such transaction and as in effect from time to time.


 


“Borrowed Debt” means any Applicable Debt
for money borrowed, including loans, hybrid securities, debt convertible into Equity Interests and any Applicable Debt for money
borrowed represented by notes, bonds, debentures or other similar evidences of Applicable Debt for money borrowed.


 


“Clearstream”
means Clearstream Banking, S.A., Luxembourg.


 


“Consolidated
Group” means the Company and its Subsidiaries.


 


“Definitive Note” means
a certificated Note that does not include the Global Notes Legend.


 


“Depository” means The
Depository Trust Company, its nominees and their respective successors.


 


“Domestic Subsidiary Holding Company”
means any Subsidiary that is organized under the laws of the United States of America, any state thereof or the District of Columbia
substantially all the assets of which consist of Equity Interests (and/or debt) in one or more Subsidiaries that are controlled
foreign corporations, as defined under Section 957 of the Internal Revenue Code.


 


“Equity Interests” means
shares of capital stock, partnership interests, membership interests in a limited liability company, beneficial interests in a
trust or other equity ownership interests in a Person, and any warrants, options or other rights entitling the holder thereof to
purchase or acquire any such equity interest.


 


“Euroclear” means Euroclear
Bank S.A./N.V., as operator of the Euroclear System.


 


“Exchange Notes” has
the meaning specified in the Registration Rights Agreement.


 


“Existing AbbVie
Notes” means the Company’s 2.500% Senior Notes due 2020, 2.300% Senior Notes due 2021, 3.375% Senior Notes
due 2021, 2.900% Senior Notes due 2022, 3.200% Senior Notes due 2022, 2.850% Senior Notes due 2023, 3.750% Senior Notes due
2023, 1.375% Senior Notes due 2024, 3.600% Senior Notes due 2025, 3.200% Senior Notes due 2026, 0.750% Senior Notes due 2027,
2.125% Senior Notes due 2028, 4.250% Senior Notes due 2028, 1.250% Senior Notes due 2031, 4.500% Senior Notes due 2035,
4.300% Senior Notes due 2036, 4.400% Senior Notes due 2042, 4.700% Senior Notes due 2045, 4.450% Senior Notes due 2046 and
4.875% Senior Notes due 2048.


 






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“Existing Credit Agreement”
means the Company’s Amended and Restated Revolving Credit Agreement, dated as of August 27, 2019, among the Company, the
lenders from time to time party thereto and JPMorgan Chase Bank, N.A., as administrative agent, as amended or supplemented from
time to time.


 


“Fixed Rate Notes” means,
collectively, the 2021 Notes, the 2022 Notes, the 2024 notes, the 2026 Notes, the 2029 Notes, the 2039 Notes and the 2049 Notes.


 


“Floating Rate Notes”
means, collectively, the May 2021 Floating Rate Notes, the November 2021 Floating Rate Notes and the 2022 Floating Rate Notes.


 


“Foreign Subsidiary”
means any Subsidiary of the Company that is organized under the laws of a jurisdiction other than one of the fifty states of the
United States of America or the District of Columbia and any Domestic Subsidiary Holding Company.


 


“GAAP” means
generally accepted accounting principles as in effect in the United States of America from time to time.


 


“Global Notes Legend”
means the legend set forth in Exhibits A1 through A10 to this Supplemental Indenture.


 


“Hedge Agreements” means
(a) any and all rate swap transactions, basis swaps, credit derivative transactions, forward rate transactions, commodity swaps,
commodity options, forward commodity contracts, equity or equity index swaps or options, bond or bond price or bond index swaps
or options or forward bond or forward bond price or forward bond index transactions, interest rate options, forward foreign exchange
transactions, cap transactions, floor transactions, collar transactions, currency swap transactions, cross-currency rate swap transactions,
currency options, spot contracts, or any other similar transactions or any combination of any of the foregoing (including any options
to enter into any of the foregoing), whether or not any such transaction is governed by or subject to any master agreement, and
(b) any and all transactions of any kind, and the related confirmations, which are subject to the terms and conditions of, or governed
by, any form of master agreement published by the International Swaps and Derivatives Association, Inc., any International Foreign
Exchange Master Agreement, or any other master agreement (any such master agreement, together with any related schedules, a “Master
Agreement”), including any such obligations or liabilities under any Master Agreement.


 


“Initial Notes” means
the Notes issued pursuant to this Supplemental Indenture on the date hereof.


 






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“Internal Revenue Code”
means the U.S. Internal Revenue Code of 1986, as amended from time to time, and the regulations promulgated and the rulings issued
thereunder.


 


“Lien” means any lien,
security interest or other charge or encumbrance of any kind, or any other type of preferential arrangement, including, without
limitation, the lien or retained security title of a conditional vendor and any easement, right of way or other encumbrance on
title to real property.


 


“May 2021 Floating Rate Notes”
means the Senior Floating Rate Notes due May 2021.


 


“Notes” means, collectively,
the Fixed Rate Notes and the Floating Rate Notes.


 


“Notes Custodian” means
the custodian with respect to a Global Note (as appointed by the Depository) or any successor person thereto, who will initially
be the Trustee.


 


“November 2021 Floating Rate Notes”
means the Senior Floating Rate Notes due November 2021.


 


“Participant” means members
of, or participants in, the Depository.


 


“Purchase Agreement”
means the Purchase Agreement, dated as of November 12, 2019, by and among the Company and the Representatives.


 


“QIB” means qualified
institutional buyer as specified in Rule 144A promulgated under the Securities Act.


 


“Registered Exchange Offer”
means the offer by the Company, pursuant to the Registration Rights Agreement, to certain Holders of Initial Notes, to issue and
deliver to such Holders, in exchange for their Initial Notes, a like aggregate principal amount of Exchange Notes in an exchange
registered under the Securities Act.


 


“Registration Rights Agreement”
means the Registration Rights Agreement, dated as of November 21, 2019, by and among the Company and the Representatives.


 


“Regulation S” means
Regulation S promulgated under the Securities Act.


 


“Regulation S Notes”
means all Notes offered and sold in an offshore transaction in reliance on Regulation S.


 


“Representatives” means
Morgan Stanley & Co. LLC, BofA Securities, Inc. and Barclays Capital Inc., as representatives of the initial purchasers named
in Schedule I to the Purchase Agreement.


 


“Restricted Notes Legend”
means the legend set forth in Section 2.5(e)(i) hereof.


 


“Restricted
Period” means with respect to any Notes the period that is 40 consecutive days beginning on and including the
later of (i) the day on which such Notes are first offered to Persons other than distributors (as defined in
Regulation S under the Securities Act) in reliance on Regulation S and (ii) the date of original issuance with
respect to such Notes.


 






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“Rule 144” means
Rule 144 promulgated under the Securities Act.


 


“Rule 144A” means
Rule 144A promulgated under the Securities Act.


 


“Rule 144A Notes” means
all Notes offered and sold to purchasers reasonably believed to be QIBs in reliance on Rule 144A.


 


“Securities Act” means
the U.S. Securities Act of 1933, as amended.


 


“Specified Allergan Debt”
means the Floating Rate Notes due March 2020 in an aggregate principal amount of $500,000,000 and the 3.0% Senior Notes due March
2020 in an aggregate principal amount of $3,500,000,000, in each case issued by Allergan Funding SCS.


 


“Subsidiary” means, with
respect to any Person, any corporation, partnership, joint venture, limited liability company, trust or estate of which (or in
which) more than 50% of the issued and outstanding Voting Stock to elect a majority of the board of directors (or similar governing
body) of such entity (irrespective of whether at the time the Equity Interests of any other class or classes of such entity shall
or might have voting power upon the occurrence of any contingency) is at the time directly or indirectly owned or controlled by
such Person, by such Person and one or more of its other Subsidiaries or by one or more of such Person’s other Subsidiaries.


 


“Transfer Restricted Note”
means any Note that bears or is required to bear a Restricted Notes Legend.


 


“Voting Stock” means
shares of capital stock issued by a corporation, or equivalent interests in any other Person, the holders of which are ordinarily,
in the absence of contingencies, entitled to vote for the election of directors (or persons performing similar functions) of such
Person, even if the right so to vote has been suspended by the happening of such a contingency.


 


Section 1.3.           
Rules of Construction.  For all purposes of this Supplemental Indenture:


 


(a)           
capitalized terms used herein without definition shall have the meanings specified in the Indenture;


 


(b)        
    all references herein to Articles and Sections, unless otherwise specified, refer to the
corresponding Articles and Sections of this Supplemental Indenture;


 


(c)           
the terms “herein,” “hereof,” “hereunder” and other words of similar import refer to
this Supplemental Indenture; and


 


(d)           
in the event of a conflict with the definition of terms in the Indenture, the definitions in this Supplemental Indenture
shall control.


 






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Article 2



THE SECURITIES


 


Section 2.1.          
Title of the Notes.  There shall be (i) a series of Securities designated the Senior Floating Rate Notes due May
2021, (ii) a series of Securities designated the Senior Floating Rate Notes due November 2021, (iii) a series of Securities designated
the Senior Floating Rate Notes due 2022, (iv) a series of Securities designated the 2.150% Senior Notes due 2021, (v) a series
of Securities designated the 2.300% Senior Notes due 2022, (vi) a series of Securities designated the 2.600% Senior Notes
due 2024, (vii) a series of Securities designated the 2.950% Senior Notes due 2026, (viii) a series of Securities designated the
3.200% Senior Notes due 2029, (ix) a series of Securities designated the 4.050% Senior Notes due 2039 and (x) a series of Securities
designated the 4.250% Senior Notes due 2049.


 


Section 2.2.          
Initial Principal Amount. The May 2021 Floating Rate Notes will be initially issued in
an aggregate principal amount of $750,000,000. The November 2021 Floating Rate Notes will be initially issued in an aggregate principal
amount of $750,000,000. The 2022 Floating Rate Notes will be initially issued in an aggregate principal amount of $750,000,000.
The 2021 Notes will be initially issued in an aggregate principal amount of $1,750,000,000. The 2022 Notes will be initially issued
in an aggregate principal amount of $3,000,000,000. The 2024 Notes will be initially issued in an aggregate principal amount of
$3,750,000,000. The 2026 Notes will be initially issued in an aggregate principal amount of 4,000,000,000. The 2029 Notes will
be initially issued in an aggregate principal amount of $5,500,000,000. The 2039 Notes will be initially issued in an aggregate
principal amount of $4,000,000,000. The 2049 Notes will be initially issued in an aggregate principal amount of $5,750,000,000.


 


Section 2.3.          
[Reserved].


 


Section 2.4.          
Form and Dating.


 


(a)          
General.  The Notes and the Trustee’s certificate of authentication shall
be substantially in the forms set forth in the corresponding Exhibits A1-A10 attached hereto (other than, (i) with respect to any
additional Notes of any series of the Notes, changes related to issue date, issue price and first Interest Payment Date of such
additional Notes, and (ii) with respect to any Exchange Notes of any series of the Notes, changes related to legends, transfer
restrictions, CUSIP/ISIN numbers and other changes customary for registered notes). The Notes may have notations, legends or endorsements
required by law, stock exchange rule or usage. Each Note shall be dated the date of its authentication. The Notes shall be
in denominations of $2,000 and integral multiples of $1,000 in excess thereof. The Notes of each series and any additional Notes
of such series subsequently issued under the Indenture, together with any Exchange Notes issued with respect to the Notes of such
series in accordance with the Registration Rights Agreement, will be treated as a single series or class for all purposes under
the Indenture, including, without limitation, waivers, amendments and redemptions; provided that, if any such additional Notes
are not fungible with the existing Notes for Federal income tax purposes, such additional Notes will have a separate CUSIP number.


 






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		i. 	The Initial Notes shall be offered and sold by the Company
pursuant to the Purchase Agreement. The Notes shall be resold initially only (A) to persons reasonably believed to be QIBs
in reliance on Rule 144A or (B) outside the United States, to persons other than “U.S. persons” as defined
in Rule 902 under the Securities Act in compliance with Regulation S. Notes may thereafter be transferred to, among
others, purchasers reasonably believed to be QIBs, and purchasers in reliance on Regulation S, subject to the restrictions
on transfer set forth herein. Notes initially resold pursuant to Rule 144A shall be issued in the form of one or more permanent
Global Notes (as defined below) in fully registered form (collectively, the “Rule 144A Global Note”) and
Notes initially resold pursuant to Regulation S shall be issued in the form of one or more permanent global securities in
fully registered form (collectively, the “Regulation S Global Note”), in each case without interest coupons
and with the Global Notes Legend and the applicable Restricted Notes Legend set forth in Section 2.5(e)(i) hereof, which shall
be deposited on behalf of the purchasers of the Notes represented thereby with the Notes Custodian and registered in the name
of the Notes Custodian or a nominee of the Depository, duly executed by the Company and authenticated by the Trustee as provided
in this Supplemental Indenture.



		 	 



		ii.	Beneficial interests in Regulation S Global Notes
may be exchanged for interests in Rule 144A Global Notes of the same series if (1) such exchange occurs in connection
with a transfer of Notes in compliance with Rule 144A and (2) the transferor of the beneficial interest in the Regulation S
Global Note first delivers to the Trustee a written certificate (in the form of the Form of Exchange Certificate attached to the
applicable Exhibit hereto) to the effect that the beneficial interest in the Regulation S Global Note, is being transferred
to a Person (A) who the transferor reasonably believes to be a QIB, (B) purchasing for its own account or the account
of a QIB in a transaction meeting the requirements of Rule 144A, and (C) in accordance with all applicable securities
laws of the States of the United States and other jurisdictions.



		 	 



		iii.	Beneficial interests in Rule 144A Global Notes may
be transferred to a Person who takes delivery in the form of an interest in a Regulation S Global Note only if the transferor
first delivers to the Trustee a written certificate (in the form of Exhibit B hereto) to the effect that such transfer is
being made in accordance with Rule 903 or 904 of Regulation S (if applicable).



		 	 



		iv.	The Rule 144A Global Notes and the Regulation S
Global Notes are collectively referred to herein as “Global Notes.”



 


The
terms and provisions contained in the Notes shall constitute, and are hereby expressly made, a part of this Supplemental
Indenture, and the Company and the Trustee, by their execution and delivery of this Supplemental Indenture, expressly agree
to such terms and provisions and to be bound thereby. However, to the extent any provision of any Note conflicts with the
express provisions of this Supplemental Indenture, the provisions of this Supplemental Indenture shall govern and be
controlling.


 






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The
Company hereby designates The Depository Trust Company as the initial Depository for the Global Notes.


 


(b)           
Global Notes.  The Notes will be issued initially in the form of one or more Global Notes in definitive, fully
registered, book-entry form. The Global Notes will be delivered to the Notes Custodian and registered in the name of the Depository
or the nominee of such Depository. The aggregate principal amount of the Global Notes may from time to time be increased or decreased
by adjustments made on the records of the Trustee and the Depository or its nominee as hereinafter provided.


 


(c)           
Book-Entry Provisions.  This Section 2.4(c) shall apply only to a Global Note deposited with or on
behalf of the Depository. The Company shall execute and the Trustee shall, in accordance with this Section 2.4(c) and
pursuant to an order of the Company, authenticate and deliver initially one or more Global Notes that (A) shall be registered
in the name of the Depository for such Global Note or Global Notes or the nominee of such Depository and (B) shall be delivered
by the Trustee to such Depository or pursuant to such Depository’s instructions or held by the Trustee as Notes Custodian.


 


Payments in respect of the principal of,
premium, if any, and interest on a Global Note registered in the name of the Depository or its nominee will be payable to the Depository
in its capacity as the registered holder under the Indenture. Under the terms of the Indenture, the Company, the Trustee and any
agent of the Company or the Trustee will treat the persons in whose names the Notes, including the Global Notes, are registered
as the owners of the Notes for the purpose of receiving payments and for all other purposes, whether or not the Notes be overdue,
and neither the Company, the Trustee nor any such agent shall be affected by notice to the contrary. Notwithstanding the foregoing,
nothing herein shall prevent the Company, the Trustee or any agent of the Company or the Trustee from giving effect to any written
certification, proxy or other authorization furnished by the Depository or impair, as between the Depository and its Participants,
the operation of customary practices of such Depository governing the exercise of the rights of a holder of a beneficial interest
in any Global Note.


 


(d)           
Definitive Notes.  Except as provided in Section 2.6, owners of a beneficial interest in the Global Notes
will not have Notes registered in their names, will not receive physical delivery of Definitive Notes and will not be considered
the registered owners or “holders” thereof under the Indenture for any purpose.


 


Section 2.5.          
Transfer and Exchange.


 


(a)          
Transfer and Exchange of Definitive Notes.  When Definitive Notes are presented to the Security Registrar with
a request:


 


(i)           
to register the transfer of such Definitive Notes; or


 






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(ii)         
to exchange such Definitive Notes for an equal principal amount of Definitive Notes of other authorized denominations, the
Security Registrar shall register the transfer or make the exchange as requested if its reasonable requirements for such transaction
are met; provided, however, that the Definitive Notes surrendered for transfer or exchange:


 


(A)         
shall be duly endorsed or accompanied by a written instrument of transfer in form reasonably satisfactory to the
Company and the Security Registrar, duly executed by the Holder thereof or his attorney duly authorized in writing; and


 


(B)         
are accompanied by the following additional information and documents, as applicable:


 


(x)       certification
(in the form set forth on the reverse side of the Initial Note) that such definitive Note is being transferred (A) to a QIB in
accordance with Rule 144A or (B) outside the United States in an offshore transaction within the meaning of Regulation S and in
compliance with Rule 903 or Rule 904 under the Securities Act; and


 


(y)       (1)
if such Definitive Notes are being delivered to the Security Registrar by a Holder for registration in the name of such Holder,
without transfer, a certification from such Holder to that effect (in the form set forth on the reverse side of the Note); or (2)
if such Definitive Notes are being transferred to the Company, a certification to that effect (in the form satisfactory to the
Trustee).


 


(b)    
       Restrictions on Transfer of a Definitive Note for a Beneficial Interest in a Global
Note.  A Definitive Note may not be exchanged for a beneficial interest in a Global Note except upon satisfaction of
the requirement set forth below. Upon receipt by the Trustee of a Definitive Note, duly endorsed or accompanied by a written
instrument of transfer in form reasonably satisfactory to the Company and the Security Registrar, together with (i)
certification (in the form set forth on the reverse side of the Initial Note) that such definitive Note is being transferred
(A) to a QIB in accordance with Rule 144A or (B) outside the United States in an offshore transaction within
the meaning of Regulation S and in compliance with Rule 903 or Rule 904 under the Securities Act and (ii)
written instructions directing the Trustee to make, or to direct the Notes Custodian to make, an adjustment on its books and
records with respect to such Global Note to reflect an increase in the aggregate principal amount of the Notes represented by
the Global Note, such instructions to contain information regarding the Depository account to be credited with such increase,
then the Trustee shall cancel such Definitive Note and cause, or direct the Notes Custodian to cause, in accordance with the
standing instructions and procedures existing between the Depository and the Notes Custodian, the aggregate principal amount
of Notes represented by the Global Note to be increased by the aggregate principal amount of the Definitive Note to be
exchanged and shall credit or cause to be credited to the account of the Person specified in such instructions a beneficial
interest in the Global Note equal to the principal amount of the Definitive Note so canceled. If no Global Notes are then
outstanding and the Global Note has not been previously exchanged for certificated securities pursuant to Section 2.6,
the Company shall issue and the Trustee shall authenticate, upon receipt of a Company Order, a new Global Note in the
appropriate principal amount.


 






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(c)          
Transfer and Exchange of Global Notes.


 


(i)           
The transfer and exchange of Global Notes or beneficial interests therein shall be effected through the Depository, in accordance
with this Supplemental Indenture (including applicable restrictions on transfer set forth herein, if any) and the procedures of
the Depository therefor. A transferor of a beneficial interest in a Global Note shall deliver a written order given in accordance
with the Depository’s procedures containing information regarding the participant account of the Depository to be credited
with a beneficial interest in such Global Note or another Global Note and such account shall be credited in accordance with such
order with a beneficial interest in the applicable Global Note and the account of the Person making the transfer shall be debited
by an amount equal to the beneficial interest in the Global Note being transferred. Transfers by an owner of a beneficial interest
in a Rule 144A Global Note to a transferee who takes delivery of such interest through a Regulation S Global Note, whether
before or after the expiration of the Restricted Period, shall be made only upon receipt by the Trustee of a certification from
the transferor to the effect that such transfer is being made in accordance with Rule 903 or Rule 904 of Regulation S
or (if available) Rule 144 under the Securities Act and that, if such transfer is being made prior to the expiration of the
Restricted Period, the interest transferred shall be held immediately thereafter through Euroclear or Clearstream.


 


(ii)          
If the proposed transfer is a transfer of a beneficial interest in one Global Note to a beneficial interest in another Global
Note, the Security Registrar shall reflect on its books and records the date and an increase in the principal amount of the Global
Note to which such interest is being transferred in an amount equal to the principal amount of the interest to be so transferred,
and the Security Registrar shall reflect on its books and records the date and a corresponding decrease in the principal amount
of the Global Note from which such interest is being transferred.


 


(iii)         
Notwithstanding any other provisions of this Supplemental Indenture (other than the provisions set forth in Section 2.4),
a Global Note may not be transferred as a whole except by the Depository to a nominee of the Depository or by a nominee of the
Depository to the Depository or another nominee of the Depository or by the Depository or any such nominee to a successor Depository
or a nominee of such successor Depository.


 


(iv)         
In the event that a Global Note is exchanged for Notes in definitive form prior to the consummation of the Registered Exchange
Offer or the effectiveness of the shelf registration statement with respect to such Notes, such Notes may be exchanged only in
accordance with such procedures as are substantially consistent with the provisions of this section (including the certification
requirements set forth on the reverse of the Initial Notes intended to ensure that such transfers comply with Rule 144, Rule 144A,
Regulation S or such other applicable exemption from registration under the Securities Act, as the case may be) and such
other procedures as may from time to time be adopted by the Company.


 






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(d)         
Restrictions on Transfer of Regulation S Global Notes.


 


(i)            Prior to the expiration
of the Restricted Period, interests in a Regulation S Global Note may only be held through Euroclear or Clearstream. During
the Restricted Period, beneficial ownership interests in a Regulation S Global Note may only be sold, pledged or transferred
through Euroclear or Clearstream in accordance with the Applicable Procedures and only (A) to the Company, (B) so long
as such security is eligible for resale pursuant to Rule 144A, to a person whom the selling holder reasonably believes is
a QIB that purchases for its own account or for the account of a QIB to whom notice is given that the resale, pledge or transfer
is being made in reliance on Rule 144A, (C) in an offshore transaction in accordance with Regulation S, (D) pursuant
to an available exemption from registration under the Securities Act or (E) pursuant to an effective registration statement
under the Securities Act, in each case in accordance with any applicable securities laws of any state of the United States; provided,
however, that prior to the expiration of the Restricted Period, transfers of beneficial interests in a Regulation S
Global Note may not be made to a U.S. person or for the account or benefit of a U.S. person. Prior to the expiration of the Restricted
Period, transfers by an owner of a beneficial interest in a Regulation S Global Note to a transferee who takes delivery of
such interest through a Rule 144A Global Note shall be made only in accordance with the Applicable Procedures, pursuant to
Rule 144 or Rule 144A and upon receipt by the Trustee of a written certification from the transferor of the beneficial
interest in the form provided on the reverse of the Initial Note to the effect that such transfer is being made to a person whom
the transferor reasonably believes is a QIB within the meaning of Rule 144A in a transaction meeting the requirements of Rule 144A.
Such written certification shall no longer be required after the expiration of the Restricted Period. In the case of a transfer
of a beneficial interest in a Regulation S Global Note for an interest in a Rule 144A Global Note, the transferee must,
at the request of the Company, deliver an opinion of counsel reasonably acceptable to the Company stating that the proposed transfer
is being made pursuant to an exemption from, or in a transaction not subject to, the registration requirements of the Securities
Act.


 


(ii)            Upon
the expiration of the Restricted Period, beneficial ownership interests in a Regulation S Global Note shall be transferable
in accordance with applicable law and the other terms of the Indenture.


 


(e)           
Legends.


 






    12


     


    

 


(i)           Except
as permitted by the following paragraphs (ii), (iii), (iv) or (v) each Note certificate evidencing the Global Notes and the
Definitive Notes (and all Notes issued in exchange therefor or in substitution thereof) shall bear a legend in substantially the
following form (each defined term in the legend being defined as such for purposes of the legend only):


 


THIS SECURITY HAS NOT BEEN REGISTERED
UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), OR THE SECURITIES LAWS OF ANY STATE OR OTHER JURISDICTION.


 


NEITHER THIS SECURITY NOR
ANY INTEREST OR PARTICIPATION HEREIN MAY BE REOFFERED, SOLD, ASSIGNED, TRANSFERRED, PLEDGED, ENCUMBERED OR OTHERWISE DISPOSED
OF IN THE ABSENCE OF SUCH REGISTRATION OR UNLESS SUCH TRANSACTION IS EXEMPT FROM, OR NOT SUBJECT TO, SUCH REGISTRATION. THE
HOLDER OF THIS SECURITY, BY ITS ACCEPTANCE HEREOF, AGREES ON ITS OWN BEHALF AND ON BEHALF OF ANY INVESTOR ACCOUNT FOR WHICH
IT HAS PURCHASED SECURITIES, TO OFFER, SELL OR OTHERWISE TRANSFER SUCH SECURITY, PRIOR TO THE DATE (THE “RESALE
RESTRICTION TERMINATION DATE”) THAT IS [IN THE CASE OF RULE 144A NOTES: ONE YEAR] [IN THE CASE OF REGULATION S
NOTES: 40 DAYS] AFTER THE LATER OF THE ISSUE DATE HEREOF OR ANY OTHER ISSUE DATE IN RESPECT OF A FURTHER ISSUANCE OF
SECURITIES OF THE SAME SERIES AND THE LAST DATE ON WHICH ABBVIE INC. OR ANY AFFILIATE OF ABBVIE INC. WAS THE OWNER OF THIS
SECURITY (OR ANY PREDECESSOR OF SUCH SECURITY), ONLY (A) TO ABBVIE INC. OR ANY SUBSIDIARY THEREOF, (B) PURSUANT TO
A REGISTRATION STATEMENT THAT HAS BEEN DECLARED EFFECTIVE UNDER THE SECURITIES ACT, (C) FOR SO LONG AS THE SECURITIES
ARE ELIGIBLE FOR RESALE PURSUANT TO RULE 144A UNDER THE SECURITIES ACT (“RULE 144A”), TO A PERSON IT
REASONABLY BELIEVES IS A “QUALIFIED INSTITUTIONAL BUYER” AS DEFINED IN RULE 144A THAT PURCHASES FOR ITS OWN
ACCOUNT OR FOR THE ACCOUNT OF A QUALIFIED INSTITUTIONAL BUYER TO WHOM NOTICE IS GIVEN THAT THE TRANSFER IS BEING MADE IN
RELIANCE ON RULE 144A IN A TRANSACTION MEETING THE REQUIREMENTS OF RULE 144A, (D) PURSUANT TO OFFERS AND SALES
TO NON-U.S. PERSONS THAT OCCUR OUTSIDE THE UNITED STATES WITHIN THE MEANING OF REGULATION S UNDER THE SECURITIES ACT,
(E) TO AN INSTITUTIONAL “ACCREDITED INVESTOR” WITHIN THE MEANING OF RULE 501(a)(1), (2), (3) OR (7)
UNDER THE SECURITIES ACT THAT IS NOT A QUALIFIED INSTITUTIONAL BUYER AND THAT IS PURCHASING FOR ITS OWN ACCOUNT OR FOR THE
ACCOUNT OF ANOTHER INSTITUTIONAL ACCREDITED INVESTOR, IN EACH CASE IN A MINIMUM PRINCIPAL AMOUNT OF THE SECURITIES
OF $250,000, FOR INVESTMENT PURPOSES AND NOT WITH A VIEW TO OR FOR OFFER OR SALE IN CONNECTION WITH ANY DISTRIBUTION IN
VIOLATION OF THE SECURITIES ACT OR (F) PURSUANT TO ANOTHER AVAILABLE EXEMPTION FROM THE REGISTRATION REQUIREMENTS OF THE
SECURITIES ACT, SUBJECT TO ABBVIE INC.’S AND THE TRUSTEE’S RIGHT PRIOR TO ANY SUCH OFFER, SALE OR TRANSFER
PURSUANT TO CLAUSES (D), (E) OR (F) TO REQUIRE THE DELIVERY OF AN OPINION OF COUNSEL, CERTIFICATION AND/OR OTHER
INFORMATION SATISFACTORY TO EACH OF THEM.


 






    13


     


    

 


Each Note evidencing a Global Note
offered and sold to QIBs pursuant to Rule 144A shall bear a legend in substantially the following form:


 


EACH PURCHASER OF THIS SECURITY
IS HEREBY NOTIFIED THAT THE SELLER OF THIS SECURITY MAY BE RELYING ON THE EXEMPTION FROM THE PROVISIONS OF SECTION 5 OF THE
SECURITIES ACT PROVIDED BY RULE 144A THEREUNDER.


 


Each Note evidencing a Global Note
offered and sold to non-U.S. persons outside the United States in reliance on Regulation S shall bear a legend substantially in
the following form:


 


BY ITS ACQUISITION HEREOF, THE HOLDER
HEREOF REPRESENTS THAT IT IS NOT A U.S. PERSON NOR IS IT PURCHASING FOR THE ACCOUNT OF A U.S. PERSON AND IS ACQUIRING THIS SECURITY
IN AN OFFSHORE TRANSACTION IN ACCORDANCE WITH REGULATION S UNDER THE SECURITIES ACT.


 


Each Global Note shall bear a legend
substantially in the following form:


 


THIS SECURITY IS A GLOBAL SECURITY
WITHIN THE MEANING OF THE INDENTURE HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME OF A DEPOSITARY OR A NOMINEE OF A DEPOSITARY.
UNLESS AND UNTIL IT IS EXCHANGED IN WHOLE OR IN PART FOR SECURITIES IN DEFINITIVE FORM IN ACCORDANCE WITH THE PROVISIONS OF THE
INDENTURE AND THE TERMS OF THE SECURITIES, TRANSFERS OF THIS GLOBAL SECURITY SHALL BE LIMITED TO TRANSFERS IN WHOLE, BUT NOT IN
PART, TO THE DEPOSITORY TRUST COMPANY, A NEW YORK CORPORATION (“DTC”), TO NOMINEES OF DTC OR TO A SUCCESSOR THEREOF
OR SUCH SUCCESSOR’S NOMINEE AND TRANSFERS OF PORTIONS OF THIS GLOBAL SECURITY SHALL BE LIMITED TO TRANSFERS MADE IN ACCORDANCE
WITH THE RESTRICTIONS SET FORTH IN THE INDENTURE REFERRED TO ON THE REVERSE HEREOF.


 


UNLESS THIS CERTIFICATE IS
PRESENTED BY AN AUTHORIZED REPRESENTATIVE OF DTC, TO ABBVIE INC., OR ITS AGENT FOR REGISTRATION OF TRANSFER, EXCHANGE OR
PAYMENT, AND ANY CERTIFICATE ISSUED IS REGISTERED IN THE NAME OF CEDE & CO. OR IN SUCH OTHER NAME AS IS REQUESTED BY AN
AUTHORIZED REPRESENTATIVE OF DTC (AND ANY PAYMENT IS MADE TO CEDE & CO. OR TO SUCH OTHER ENTITY AS IS REQUESTED BY AN
AUTHORIZED REPRESENTATIVE OF DTC), ANY TRANSFER, PLEDGE OR OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS
WRONGFUL INASMUCH AS THE REGISTERED OWNER HEREOF, CEDE & CO., HAS AN INTEREST HEREIN.


 






    14


     


    

 


Each Note in definitive form shall
bear the following additional legend:


 


IN CONNECTION WITH ANY TRANSFER,
THE HOLDER WILL DELIVER TO THE REGISTRAR AND TRANSFER AGENT SUCH CERTIFICATES AND OTHER INFORMATION AS SUCH TRANSFER AGENT MAY
REASONABLY REQUIRE TO CONFIRM THAT THE TRANSFER COMPLIES WITH THE FOREGOING RESTRICTIONS.


 


(ii)           Upon
any sale or transfer of a Transfer Restricted Note that is a definitive Note, the Security Registrar shall permit the Holder thereof
to exchange such Transfer Restricted Note for a definitive Note that does not bear the legends set forth above and rescind any
restriction on the transfer of such Transfer Restricted Note if the Holder certifies in writing to the Security Registrar that
its request for such exchange was made in reliance on Rule 144 (such certification to be in the form set forth on the reverse
of the Initial Note).


 


(iii)          After
a transfer of any Initial Notes during the period of the effectiveness of a shelf registration statement with respect to such Initial
Notes, as the case may be, all requirements pertaining to the Restricted Notes Legend on such Initial Notes shall cease to apply
and the requirements that any such Initial Notes be issued in global form shall continue to apply.


 


(iv)          Upon
the consummation of a Registered Exchange Offer with respect to the Initial Notes pursuant to which Holders of such Initial Notes
are offered Exchange Notes in exchange for their Initial Notes, all requirements pertaining to Initial Notes that Initial Notes
be issued in global form shall continue to apply, and Exchange Notes in global form without the Restricted Notes Legend shall be
available to Holders that exchange such Initial Notes in such Registered Exchange Offer.


 


(v)           Upon
a sale or transfer after the expiration of the Restricted Period of any Initial Note acquired pursuant to Regulation S, all
requirements that such Initial Note bear the Restricted Notes Legend shall cease to apply and the requirements requiring any such
Initial Note be issued in global form shall continue to apply.


 


(f)           
By its acceptance of any Note bearing any legend in Section 2.5(e)(i) hereof, each Holder of such Note acknowledges
the restrictions on transfer of such Note set forth in this Supplemental Indenture and in such legend in Section 2.5(e)(i)
hereof and agrees that it shall transfer such Note only as provided in this Supplemental Indenture.


 






    15


     


    

 


(g)          
Cancellation or Adjustment of Global Note. At such time as all beneficial interests in a Global Note have either
been exchanged for Definitive Notes, transferred, redeemed, repurchased or canceled, such Global Note shall be returned by the
Depository to the Trustee for cancellation or retained and canceled by the Trustee. At any time prior to such cancellation, if
any beneficial interest in a Global Note is exchanged for Definitive Notes, transferred in exchange for an interest in another
Global Note, redeemed, repurchased or canceled, the principal amount of Notes represented by such Global Note shall be reduced
and an adjustment shall be made on the books and records of the Trustee (if it is then the Notes Custodian for such Global Note)
with respect to such Global Note, by the Trustee or the Notes Custodian, to reflect such reduction.


 


(h)          
Obligations with Respect to Transfers and Exchanges of Notes.


 


(i)           
To permit registrations of transfers and exchanges, the Company shall execute and the Trustee shall authenticate, Definitive
Notes and Global Notes at the Security Registrar’s request.


 


(ii)          
No service charge shall be made for any registration of transfer or exchange of the Notes, but the Company or the Security
Registrar may require payment of a sum sufficient to cover any transfer tax, assessments, or similar governmental charge payable
in connection therewith (other than any such transfer taxes, assessments or similar governmental charge payable upon exchange or
transfer pursuant to Sections 9.6 or 11.7 of the Indenture).


 


(i)           
Prior to the due presentation for registration of transfer of any Note, the Company, the Trustee, the Paying Agent or the
Security Registrar may deem and treat the person in whose name a Note is registered as the absolute owner of such Note for the
purpose of receiving payment of principal of and interest on such Note and for all other purposes whatsoever, whether or not such
Note is overdue, and none of the Company, the Trustee, the Paying Agent or the Security Registrar shall be affected by notice to
the contrary.


 


(j)           
The Company hereby appoints the Trustee as Security Registrar for the Notes. Neither the Company nor the Security Registrar
shall be required to register the transfer of or exchange Notes of any series (i) during a period beginning at the opening
of business 15 days before the day of the mailing of a notice of redemption of Notes of that series selected for redemption under
Section 11.3 of the Indenture and ending at the close of business on the day of such mailing, or (ii) so selected for
redemption in whole or in part, except the unredeemed portion of any Note being redeemed in part.


 


(k)          
All Notes issued upon any transfer or exchange pursuant to the terms of this Supplemental Indenture shall evidence the same
Debt and shall be entitled to the same benefits under the Indenture as the Notes surrendered upon such transfer or exchange.


 


(l)           
No Obligation of the Trustee.


 






    16


     


    

 


(i)           
The Trustee shall have no responsibility or obligation to any beneficial owner of a Global Note, a member of, or a participant
in, the Depository or any other Person with respect to the accuracy of the records of the Depository or its nominee or of any participant
or member thereof, with respect to any ownership interest in the Notes or with respect to the delivery to any participant, member,
beneficial owner or other Person (other than the Depository) of any notice (including any notice of redemption or repurchase) or
the payment of any amount, under or with respect to such Notes. All notices and communications to be given to the Holders and all
payments to be made to Holders under the Notes shall be given or made only to the registered Holders (which shall be the Depository
or its nominee in the case of a Global Note). The rights of beneficial owners in any Global Note shall be exercised only through
the Depository subject to the applicable rules and procedures of the Depository. The Trustee may rely and shall be fully protected
in relying upon information furnished by the Depository with respect to its members, participants and any beneficial owners.


 


(ii)          
The Trustee shall have no obligation or duty to monitor, determine or inquire as to compliance with any restrictions on
transfer imposed under this Supplemental Indenture or under applicable law with respect to any transfer of any interest in any
Note (including any transfers between or among Depository participants, members or beneficial owners in any Global Note) other
than to require delivery of such certificates and other documentation or evidence as are expressly required by, and to do so if
and when expressly required by, the terms of this Supplemental Indenture, and to examine the same to determine substantial compliance
as to form with the express requirements hereof.


 


Section 2.6.          
Definitive Notes.


 


(a)           
A Global Note deposited with the Depository or with the Trustee as Notes Custodian pursuant to Section 2.4 shall be
transferred to the beneficial owners thereof in the form of Definitive Notes in an aggregate principal amount equal to the principal
amount of such Global Note, in exchange for such Global Note, only if such transfer complies with Section 2.5 and (i) the
Depository (A) notifies the Company that the Depository is no longer willing or able to act as a depositary or clearing system
for the Notes or (B) ceases to be a “clearing agency” registered under the Securities Exchange Act of 1934, as
amended, and in either event, a successor depositary or clearing system is not appointed by the Company within 90 days of such
notice or cessation, (ii) upon the occurrence and continuation of an Event of Default and the Depository notifies the Trustee
of its decision to exchange the Global Note for Definitive Notes, or (iii) the Company determines not to have the Notes represented
by a Global Note.


 


(b)            Any
Global Note that is transferable to the beneficial owners thereof pursuant to this Section 2.6 shall be surrendered by
the Depository to the Trustee, to be so transferred, in whole or from time to time in part, without charge, and upon
Company Order the Trustee shall authenticate and deliver, upon such transfer of each portion of such Global Note, an equal
aggregate principal amount of Definitive Notes of authorized denominations. Any portion of a Global Note transferred pursuant
to this Section 2.6 shall be executed, authenticated and delivered only denominations of $2,000 of principal amount and
any integral multiple of $1,000 in excess thereof and registered in such names as requested by or on behalf of the Depository
(in accordance with its customary procedures).


 






    17


     


    

 


(c)           
The registered Holder of a Global Note may grant proxies and otherwise authorize any Person, including Participants and
Persons that may hold interests through Participants, to take any action which a Holder is entitled to take under the Indenture
or the Notes.


 


(d)           
In the event of the occurrence of any of the events specified in Section 2.6(a)(i), (ii) or (iii), the Company will
promptly make available to the Trustee a reasonable supply of Definitive Notes in fully registered form without interest coupons.


 


Article 3


GUARANTEES


 


Section 3.1.          
Future Guarantors.


 


On the date that is 90 days
after the closing date of the Acquisition, the punctual payment when due of all monetary obligations of the Company under the
Indenture (with respect to the Securities and the obligations to the Trustee under Section 6.7 of the Indenture) and the
Securities, whether for principal of or interest on the Securities, will be, jointly and severally, unconditionally
guaranteed (the “Guarantees”) on an unsubordinated unsecured basis by each direct or indirect existing or
future wholly-owned Subsidiary of the Company that guarantees (A) any Borrowed Debt of Allergan or any of its Subsidiaries
(other than the Specified Allergan Debt and other than any intercompany Borrowed Debt owed to another member of the
Consolidated Group), so long as the aggregate principal amount of such guaranteed Borrowed Debt issued by any such Person
exceeds $3,000,000,000, or (B) (x) the Company’s obligations under the Existing Credit Agreement, (y) the
Company’s obligations under the Existing AbbVie Notes and/or (z) the Company’s obligations under any other
Borrowed Debt (other than any intercompany Borrowed Debt owed to another member of the Consolidated Group), that is
outstanding for clauses (x) - (z) in an aggregate committed (with respect to clause (x) above) and principal (with respect to
clauses (y) and (z) above) amount of at least $2,000,000,000, in each case pursuant to a supplemental indenture provided for
by Section 3.2 hereof (each such Subsidiary executing and delivering a Guarantee, a “Guarantor” and,
collectively, the “Guarantors”); provided that no such Guarantee by a Foreign Subsidiary shall be
required to the extent the provision of such Guarantee would (1) give rise to a material adverse tax consequence to the
Company or any of its direct or indirect Subsidiaries or any of its shareholders (including any tax consequences resulting
from the application of Section 956 of the Internal Revenue Code) or (2) otherwise be prohibited by applicable law (or, with
respect to any temporary restrictions, including limitations imposed under financial assistance rules or similar local laws,
unless and until such temporary restrictions have been removed) or requires the approval or consent of any governmental
authority or any other Person that is not a member of the Consolidated Group or that would cause a default or event of
default (or similar events) under the Applicable Debt of such Subsidiary; provided, further that (i) the
relevant Guarantor shall use reasonable efforts to overcome any such prohibition or restriction and (ii) to the extent the
provision of any Guarantee would be limited (though not prohibited) under the laws of any applicable jurisdiction (for
example, under fraudulent conveyance or general statutory limitations, financial assistance, corporate benefit or “thin
capitalization” rules, or fiduciary duty or corporate law), such Guarantee shall only be provided subject to such
limitations (as determined in good faith by the Company in its sole discretion).


 






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Section 3.2            Execution
and Delivery of Guarantees.


 


Pursuant to Section 3.1 hereof,
the Company shall cause each Guarantor to execute and deliver to the Trustee a supplemental indenture substantially in the form
set forth in Exhibit C hereto, or otherwise in form reasonably satisfactory to the Trustee, evidencing its Guarantees on substantially
the terms set forth in this article.


 


Article 4


AMENDMENTS TO THE BASE INDENTURE


 


Section 4.1.      
     Amendment to Section 1.1 of the Indenture. Section 1.1 of the
Indenture is hereby amended by adding the following definitions thereto: 


 


“Guarantees”
means each Guarantor’s unconditional guarantee to each Holder of the Securities and to the Trustee and its successor and
assigns on an unsubordinated unsecured basis of the punctual payment when due of all monetary obligations of the Company under
the Indenture and the Securities, whether for principal of or interest on the Securities, if any.


 


“Guarantor”
means each of the Company’s direct or indirect existing or future wholly-owned subsidiaries, if any, that executes a supplemental
indenture guaranteeing the outstanding Securities from and after the date it executes such supplemental indenture until the date
that such subsidiary is released from its Guarantees.


 


Section 4.2.          
Amendment to Section 4.1 of the Indenture. Solely as it relates to the Notes, Section 4.1
of the Indenture shall be amended by replacing subsection (1)(B) with the following:


 


(B)          all
of the Securities of such series not theretofore delivered to the Trustee for cancellation


 


(i)           
have become due and payable,


 


(ii)          
will become due and payable at their Stated Maturity within one year, or


 


(iii)         
if redeemable at the Company’s option, are to be called for redemption within one year under arrangements satisfactory
to the Trustee for the giving of notice of redemption by the Trustee in the name, and at the expense, of the Company,


 






    19


     


    

 


and the Company, in the case of (i), (ii) or (iii) above,
has irrevocably deposited or caused to be deposited with the Trustee funds in an amount sufficient to pay and discharge the entire
indebtedness on the Securities of such series not theretofore delivered to the Trustee for cancellation, for principal of, premium,
if any, and interest on the Securities of such series to the date of such deposit (in the case of Securities which have become
due and payable), or to their Stated Maturity or the Redemption Date, as the case may be (provided that in connection with any
discharge relating to any redemption that requires the payment of a premium, the amount deposited shall be sufficient for purposes
of the Indenture to the extent that an amount is deposited with the Trustee equal to the premium calculated as of the date of the
notice of redemption, with any deficit as of the Redemption Date only required to be deposited with the Trustee on or prior to
the Redemption Date), together with irrevocable instructions from the Company directing the Trustee to apply such funds to the
payment thereof at Maturity or the Redemption Date, as the case may be;


 


Section 4.3.          
Amendment of Section 5.1 to the Indenture. Solely as it relates to the Notes, Section 5.1
of the Indenture shall be amended by: 


 


(a) replacing subsection (4) with
the following: “default in the performance, or breach, of any covenant or warranty of the Company in this Indenture (other
than a covenant or warranty a default in whose performance or whose breach is elsewhere in this Section specifically dealt
with or which has expressly been included in this Indenture solely for the benefit of series of Securities other than that series),
and continuance of such default or breach for a period of 90 days after the giving of written notice to the Company by the Trustee
or to the Company and the Trustee by the Holders of at least 25% in principal amount of the Outstanding Securities of that series
a written notice specifying such default or breach and requiring it to be remedied and stating that such notice is a “Notice
of Default” hereunder (provided that such notice may not be given with respect to any action taken, and reported publicly
or to holders of the Securities more than two years prior to such notice);”


 


(b) (i) deleting the “.”
and (ii) adding “; or” at the end of subsection (7) thereof;


 


(c)
adding a new subsection (8) that states the following: “any Guarantee with respect to the Securities is not issued as required
by Article 3 of the Supplemental Indenture No. 7, dated as of November 21, 2019, or ceases to be in full force and effect (except
as contemplated by the terms thereof) or the applicable Guarantor asserts in writing that its obligations under its Guarantee with
respect to such series of Securities has ceased to be or otherwise is not in full force and effect (except as contemplated by the
terms thereof);” and


 






    20


     


    

 


(d)
adding the following paragraph at the end of Section 5.1: “Any time period in this Indenture to cure any actual or alleged
default or Event of Default may be extended or stayed by a court of competent jurisdiction.”


 


Section 4.4.          
Amendment of Section 11.2 to the Indenture. Solely as it relates to the Notes, Section
11.2 of the Indenture shall be amended by replacing “45 days” with “30 days.”


 


Section 4.5.          
Amendment of Section 11.3 to the Indenture. Solely as it relates to the Notes, Section
11.2 of the Indenture shall be amended by replacing “45 days” with “30 days” in each instance it appears.



 


Section 4.6.          
Amendment of Section 11.4 to the Indenture. Solely as it relates to the Notes, Section
11.4 of the Indenture shall be amended by:


 


(a)           
replacing the first sentence with the following: “Notice of redemption shall be given electronically or by first-class
mail, postage prepaid, to each Holder of Securities to be redeemed, at his address appearing in the Security Register, or otherwise
in accordance with the applicable procedures of DTC, sent or mailed not less than 15 nor more than 60 days prior to the Redemption
Date.”; and


 


(b)           
adding the following sentence to the end of Section 11.4: “Any redemption or notice of redemption may, at the Company’s
discretion, be subject to one or more conditions precedent, and, at the Company’s discretion, the redemption date may be
delayed until such time as any or all such conditions shall be satisfied.”


 


Section 4.7.          
Amendment to Section 13.4 of the Indenture. Solely as it relates to the Notes, Section 13.4 of the Indenture
shall be amended by replacing subsections (5) and (6) with the following:


 


		(5)	In the case of an election under Section 13.2, the Company shall have delivered to the Trustee an Opinion of Counsel stating
that (x) the Company has received from, or there has been published by, the Internal Revenue Service a ruling, or (y) since
the date of this Indenture there has been a change in the applicable Federal income tax law, in either case to the effect that,
and based thereon such opinion shall confirm that, the beneficial owners of the Outstanding Securities of such series will not
recognize income, gain or loss for Federal income tax purposes as a result of such defeasance and will be subject to Federal income
tax in the same manner as would have been the case if such defeasance had not occurred.



 


		(6)	In the case of an election under Section 13.3, the Company shall have delivered to the Trustee an Opinion of Counsel to
the effect that the beneficial owners of the Outstanding Securities of such series will not recognize income, gain or loss for
Federal income tax purposes as a result of such covenant defeasance and will be subject to Federal income tax in the same manner
as would have been the case if such covenant defeasance had not occurred.



 






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Article 5


MISCELLANEOUS PROVISIONS


 


Section 5.1.          
Ratification.  The Indenture, as supplemented and amended by this Supplemental Indenture, is in all respects hereby
adopted, ratified and confirmed.


 


Section 5.2.          
Counterparts.  This Supplemental Indenture may be executed in any number of counterparts, each of which when so
executed shall be deemed an original, and all such counterparts shall together constitute but one and the same instrument.


 


Section 5.3.          
Governing Law.  THIS SUPPLEMENTAL INDENTURE AND EACH NOTE SHALL BE GOVERNED BY AND CONSTRUED IN ACCORDANCE WITH
THE LAWS OF THE STATE OF NEW YORK.


 


Section 5.4.          
Conflict with Trust Indenture Act.  If any provision hereof limits, qualifies or conflicts with a provision of
the Trust Indenture Act that is required under such Act to be a part of and govern this Supplemental Indenture, the latter provision
shall control.  If any provision of this Supplemental Indenture modifies or excludes any provision of the Trust Indenture
Act that may be so modified or excluded, the latter provision shall be deemed to apply to this Supplemental Indenture as so modified
or to be excluded, as the case may be.


 


Section 5.5.          
The Trustee.  The recitals contained herein and in the Securities, except the Trustee’s certificates of authentication,
shall be taken as the statements of the Company, and the Trustee assumes no responsibility for their correctness.  The Trustee
makes no representations as to the validity or sufficiency of this Supplemental Indenture or of the Securities.


 


[signature pages follow]


 






    22


     


    

 


IN WITNESS WHEREOF, the parties hereto
have caused this Supplemental Indenture No. 7 to be duly executed as of the day and year first above written.


 


	 	ABBVIE INC.
	 	 
		By:	/s/ Tabetha A. Skarbek 
	 	 	Name:	 Tabetha A. Skarbek
	 	 	Title:	Vice President and Treasurer


 


 





	 	U.S. BANK NATIONAL ASSOCIATION,
	 	as Trustee
	 	 
		By:	/s/ Linda E. Garcia
	 	 	Name:	 Linda E. Garcia
	 	 	Title:	Vice President 


 


[Signature Page to Supplemental Indenture No. 7]


 



    


     


    




 





EXHIBIT A1


 


(FORM OF FACE OF INITIAL NOTE)


 


[THIS SECURITY IS A GLOBAL SECURITY WITHIN THE MEANING OF THE
INDENTURE HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME OF A DEPOSITARY OR A NOMINEE OF A DEPOSITARY. UNLESS AND UNTIL
IT IS EXCHANGED IN WHOLE OR IN PART FOR SECURITIES IN DEFINITIVE FORM IN ACCORDANCE WITH THE PROVISIONS OF THE INDENTURE
AND THE TERMS OF THE SECURITIES, TRANSFERS OF THIS GLOBAL SECURITY SHALL BE LIMITED TO TRANSFERS IN WHOLE, BUT NOT IN PART, TO
THE DEPOSITORY TRUST COMPANY, A NEW YORK CORPORATION (“DTC”), TO NOMINEES OF DTC OR TO A SUCCESSOR THEREOF OR SUCH
SUCCESSOR’S NOMINEE AND TRANSFERS OF PORTIONS OF THIS GLOBAL SECURITY SHALL BE LIMITED TO TRANSFERS MADE IN ACCORDANCE WITH
THE RESTRICTIONS SET FORTH IN THE INDENTURE REFERRED TO ON THE REVERSE HEREOF.


 


UNLESS THIS CERTIFICATE IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE
OF DTC, TO ABBVIE INC., OR ITS AGENT FOR REGISTRATION OF TRANSFER, EXCHANGE OR PAYMENT, AND ANY CERTIFICATE ISSUED IS REGISTERED
IN THE NAME OF CEDE & CO. OR IN SUCH OTHER NAME AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC (AND ANY PAYMENT
IS MADE TO CEDE & CO. OR TO SUCH OTHER ENTITY AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC), ANY TRANSFER,
PLEDGE OR OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL INASMUCH AS THE REGISTERED OWNER HEREOF, CEDE &
CO., HAS AN INTEREST HEREIN.](1)


 


THIS SECURITY HAS NOT BEEN REGISTERED UNDER THE SECURITIES ACT
OF 1933, AS AMENDED (THE “SECURITIES ACT”), OR THE SECURITIES LAWS OF ANY STATE OR OTHER JURISDICTION.


 






    A-1-1


     


    




 


NEITHER THIS SECURITY NOR ANY INTEREST OR PARTICIPATION HEREIN
MAY BE REOFFERED, SOLD, ASSIGNED, TRANSFERRED, PLEDGED, ENCUMBERED OR OTHERWISE DISPOSED OF IN THE ABSENCE OF SUCH REGISTRATION
OR UNLESS SUCH TRANSACTION IS EXEMPT FROM, OR NOT SUBJECT TO, SUCH REGISTRATION. THE HOLDER OF THIS SECURITY, BY ITS ACCEPTANCE
HEREOF, AGREES ON ITS OWN BEHALF AND ON BEHALF OF ANY INVESTOR ACCOUNT FOR WHICH IT HAS PURCHASED SECURITIES, TO OFFER, SELL OR
OTHERWISE TRANSFER SUCH SECURITY, PRIOR TO THE DATE (THE “RESALE RESTRICTION TERMINATION DATE”) THAT IS [IN THE CASE
OF RULE 144A NOTES: ONE YEAR] [IN THE CASE OF REGULATION S NOTES: 40 DAYS] AFTER THE LATER OF THE ISSUE DATE HEREOF OR ANY OTHER
ISSUE DATE IN RESPECT OF A FURTHER ISSUANCE OF SECURITIES OF THE SAME SERIES AND THE LAST DATE ON WHICH ABBVIE INC. OR ANY AFFILIATE
OF ABBVIE INC. WAS THE OWNER OF THIS SECURITY (OR ANY PREDECESSOR OF SUCH SECURITY), ONLY (A) TO ABBVIE INC. OR ANY SUBSIDIARY
THEREOF, (B) PURSUANT TO A REGISTRATION STATEMENT THAT HAS BEEN DECLARED EFFECTIVE UNDER THE SECURITIES ACT, (C) FOR
SO LONG AS THE SECURITIES ARE ELIGIBLE FOR RESALE PURSUANT TO RULE 144A UNDER THE SECURITIES ACT (“RULE 144A”),
TO A PERSON IT REASONABLY BELIEVES IS A ‘‘QUALIFIED INSTITUTIONAL BUYER’’ AS DEFINED IN RULE 144A
THAT PURCHASES FOR ITS OWN ACCOUNT OR FOR THE ACCOUNT OF A QUALIFIED INSTITUTIONAL BUYER TO WHOM NOTICE IS GIVEN THAT THE TRANSFER
IS BEING MADE IN RELIANCE ON RULE 144A IN A TRANSACTION MEETING THE REQUIREMENTS OF RULE 144A, (D) PURSUANT TO OFFERS
AND SALES TO NON-U.S. PERSONS THAT OCCUR OUTSIDE THE UNITED STATES WITHIN THE MEANING OF REGULATION S UNDER THE SECURITIES
ACT, (E) TO AN INSTITUTIONAL “ACCREDITED INVESTOR” WITHIN THE MEANING OF RULE 501(a)(1), (2), (3) OR
(7) UNDER THE SECURITIES ACT THAT IS NOT A QUALIFIED INSTITUTIONAL BUYER AND THAT IS PURCHASING FOR ITS OWN ACCOUNT OR FOR
THE ACCOUNT OF ANOTHER INSTITUTIONAL ACCREDITED INVESTOR, IN EACH CASE IN A MINIMUM PRINCIPAL AMOUNT OF THE SECURITIES OF
$250,000, FOR INVESTMENT PURPOSES AND NOT WITH A VIEW TO OR FOR OFFER OR SALE IN CONNECTION WITH ANY DISTRIBUTION IN VIOLATION
OF THE SECURITIES ACT OR (F) PURSUANT TO ANOTHER AVAILABLE EXEMPTION FROM THE REGISTRATION REQUIREMENTS OF THE SECURITIES
ACT, SUBJECT TO ABBVIE INC.’S AND THE TRUSTEE’S RIGHT PRIOR TO ANY SUCH OFFER, SALE OR TRANSFER PURSUANT TO CLAUSES (D),
(E) OR (F) TO REQUIRE THE DELIVERY OF AN OPINION OF COUNSEL, CERTIFICATION AND/OR OTHER INFORMATION SATISFACTORY TO EACH
OF THEM.


 


[EACH PURCHASER OF THIS SECURITY IS HEREBY NOTIFIED THAT THE
SELLER OF THIS SECURITY MAY BE RELYING ON THE EXEMPTION FROM THE PROVISIONS OF SECTION 5 OF THE SECURITIES ACT PROVIDED
BY RULE 144A THEREUNDER.](2)


 


[BY ITS ACQUISITION HEREOF, THE HOLDER HEREOF REPRESENTS THAT
IT IS NOT A U.S. PERSON NOR IS IT PURCHASING FOR THE ACCOUNT OF A U.S. PERSON AND IS ACQUIRING THIS SECURITY IN AN OFFSHORE TRANSACTION
IN ACCORDANCE WITH REGULATION S UNDER THE SECURITIES ACT.](3)


 


[IN CONNECTION WITH ANY TRANSFER, THE HOLDER WILL DELIVER TO
THE REGISTRAR AND TRANSFER AGENT SUCH CERTIFICATES AND OTHER INFORMATION AS SUCH TRANSFER AGENT MAY REASONABLY REQUIRE TO
CONFIRM THAT THE TRANSFER COMPLIES WITH THE FOREGOING RESTRICTIONS.](4)


 





 








(1) Applies to Global Notes only


 


(2) Applies to Rule 144A Notes only


 


(3) Applies to Regulation S Notes only


 


(4) Applies to Notes in definitive form only


 






    A-1-2


     


    

 


ABBVIE INC.


 


Senior Floating Rate Notes due May 2021


 


	No. [●]	$[●]


 


CUSIP No: [●]


 


ISIN No: [●]


 


ABBVIE
INC., a corporation duly organized and existing under the laws of Delaware (herein called the “Company,” which
term includes any successor Person under the Indenture and Supplemental Indenture hereinafter referred to), for value received,
hereby promises to pay to Cede & Co., as nominee for The Depository Trust Company, or registered assigns, the principal
sum of [●] Dollars ($[●]), or such other principal sum as may be indicated on the Schedule of Exchanges attached hereto,
on May 21, 2021 (the “Maturity Date”), and to pay interest thereon from November 21, 2019 (the
 “Original Issue Date”) or from the most recent Interest Payment Date (as defined below) to which interest has
been paid or duly provided for, quarterly in arrears on February 21, May 21, August 21 and November 21 of each
year, commencing on February 21, 2020, subject to adjustment as provided below (each, an “Interest Payment Date”),
at a rate equal to the Benchmark (as defined on the reverse hereof), which will initially be three-month LIBOR (as defined on the
reverse hereof) plus 35 basis points and reset (as provided on the reverse hereof) on each February 21, May 21, August 21
and November 21 (each, an “Interest Reset Date”) after the Original Issue Date until the principal hereof
is paid or made available for payment. Interest payments on this Security will include interest accrued to but excluding the Interest
Payment Date or Maturity Date, as the case may be. The interest so payable, and punctually paid or duly provided for, on any Interest
Payment Date will, as provided in such Indenture, be paid to the Person in whose name this Security (or one or more Predecessor
Securities) is registered at the close of business on the Regular Record Date for such interest, which shall be the date that is
15 calendar days prior to the relevant Interest Payment Date (whether or not such record date is a Business Day); provided, however,
that interest payable at maturity of this Note shall be payable to the persons to whom principal shall be payable, subject to DTC’s
applicable procedures. Any such interest not so punctually paid or duly provided for will forthwith cease to be payable
to the Holder on such Regular Record Date and may either be paid to the Person in whose name this Security (or one or more Predecessor
Securities) is registered at the close of business on a Special Record Date for the payment of such Defaulted Interest to be fixed
by the Trustee, notice whereof shall be given to Holders of Securities of this series not less than 10 days prior to such Special
Record Date, or be paid at any time in any other lawful manner not inconsistent with the requirements of any securities exchange
on which the Securities of this series may be listed, and upon such notice as may be required by such exchange, all as more fully
provided in said Indenture.


 


If any Interest Reset Date for this Security
would otherwise be a day that is not a Business Day, such Interest Reset Date will be the next succeeding day that is a Business
Day, except that if the Business Day is in the next succeeding calendar month, the Interest Reset Date will be the immediately
preceding day that is a Business Day. “Business Day” means any calendar day that is not a Saturday, Sunday or
legal holiday in New York, New York and on which commercial banks are open for business in New York, New York. If any Interest
Payment Date (other than an interest payment date occurring on the Maturity Date) falls on a day that is not a Business Day, such
Interest Payment Date will be the following day that is a Business Day, except that, if the Business Day is in the next succeeding
calendar month, the Interest Payment Date shall be the immediately preceding day that is a Business Day (in each case, resulting
in a corresponding adjustment to the number of days in the applicable interest period). If the Maturity Date falls on a day that
is not a Business Day, the payment of principal and interest may be made on the next succeeding Business Day, and no interest on
that payment shall accrue for the period from and after such maturity.


 






    A-1-3


     


    

 


Accrued interest is calculated by multiplying
the face amount by an accrued interest factor. The accrued interest factor is computed by adding the interest factor calculated
for each day from the Original Issue Date, or from, and including, the last Interest Payment Date, to, but excluding, the date
for which accrued interest is being calculated. The “interest factor” for each day is computed by dividing the interest
rate applicable to that day by 360. All percentages resulting from any calculation will be rounded, if necessary, to the nearest
one hundred-thousandth of a percentage point, with five one-millionths of a percentage point rounded upward (e.g., 9.876545% (or
..09876545) will be rounded upward to 9.87655% (or .0987655)), and all amounts used in or resulting from the calculation will be
rounded to the nearest cent (with one-half cent being rounded upward).


 


The calculation of the interest rate on
this Security will be made by U.S. Bank National Association, as “calculation agent.” If at any time the Trustee (as
defined on the reverse hereof) is not also the calculation agent, the Company will notify (or cause the calculation agent to notify)
the Trustee of each determination of the interest rate promptly after the determination is made by any successor calculation agent.
All calculations made by the calculation agent shall in the absence of manifest error be conclusive for all purposes and binding
on the Company, the Trustee and the Holder. Upon the request of the Holder, the Trustee will provide the interest rate then in
effect and, if determined, the interest rate that will become effective as a result of a determination made for the next Interest
Reset Date. The interest rate on this Security will in no event be higher than the maximum rate permitted by New York law, as the
same may be modified by United States law of general application.


 


Payment of the principal of (and premium,
if any) and any such interest on this Security will be made at the office or agency of the Company maintained for that purpose
in St. Paul, Minnesota, in such coin or currency of the United States of America as at the time of payment is legal tender for
payment of public and private debts; provided, however, that at the option of the Company payment of interest may be made by (1) check
mailed to the address of the Person entitled thereto as such address shall appear in the Security Register or (2) wire transfer
as directed by the Holder, in immediately available funds to an account maintained by the Depository or its nominee with respect
to a Global Note, and to the Holder or its nominee with respect to a Definitive Note; provided further that in the case of a Definitive
Note (1) the Holder thereof shall have provided written wiring instructions to the Trustee on or before the related Regular
Record Date and (2) if appropriate instructions for any such wire transfer are not received by the related Regular Record
Date, then such payment shall be made by check mailed to the address of the Holder specified in the Security Register.








 






    A-1-4


     


    

 


Reference is hereby made to the further
provisions of this Security set forth on the reverse hereof, which further provisions shall for all purposes have the same effect
as if set forth at this place.


 


Unless the certificate of authentication
hereon has been executed by the Trustee referred to herein by manual signature, this Security shall not be entitled to any benefit
under the Indenture or be valid or obligatory for any purpose.



 






    	 	 A-1-5 	 



     


    

 


IN WITNESS WHEREOF, the Company has caused
this instrument to be duly executed.


 


Dated: November 21, 2019


 


	 	ABBVIE INC.
	 	 
	 	By:
	 	 	Name:
	 	 	Title:


 






    A-1-6


     


    

 


TRUSTEE’S CERTIFICATE OF AUTHENTICATION


 


This is one of the Securities of the series
designated therein referred to in the within-mentioned Indenture.


 


Dated: November 21, 2019


 


	 	U.S. BANK NATIONAL ASSOCIATION,
	 	as Trustee
	 	 
	 	By:
	 	Authorized Signatory


 






    A-1-7


     


    

 


[FORM OF REVERSE OF SECURITY]


 


This Security is one of a duly authorized
issue of securities of the Company (herein called the “Securities”), issued and to be issued in one or more
series under an Indenture, dated as of November 8, 2012, as it may be supplemented or amended from time to time (herein called
the “Indenture”), between the Company and U.S. Bank National Association, as Trustee (herein called the “Trustee,”
which term includes any successor trustee under the Indenture), and Supplemental Indenture No. 7, dated as of November 21,
2019 (herein called the “Supplemental Indenture”), between the Company and the Trustee, to which Indenture,
Supplemental Indenture and all indentures supplemental thereto reference is hereby made for a statement of the respective rights,
limitations of rights, duties and immunities thereunder of the Company, the Trustee and the Holders of the Securities of this series
and of the terms upon which the Securities of this series are, and are to be, authenticated and delivered. This Security is one
of the series designated on the face hereof, in an initial aggregate principal amount of $[●].


 


Interest


 


The interest rate in effect with respect
to the Securities of this series on each day that is not an Interest Reset Date will be the interest rate determined as of the
LIBOR Interest determination date (as defined below) pertaining to the immediately preceding Interest Reset Date and the interest
rate in effect on any day that is an Interest Reset Date will be the interest rate determined as of the LIBOR Interest determination
date pertaining to that Interest Reset Date, subject in either case to applicable provisions of law.


 


“LIBOR” means the rate determined
in accordance with the following provisions:


 


		(a)	With respect to a LIBOR Interest determination date, LIBOR will be the rate for deposits in U.S. dollars having a maturity
of three months, commencing on the first day of the applicable interest period immediately following that LIBOR Interest determination
date, that appears on the display on Reuters (or any successor service) on the LIBOR 01 page (or any other page as may
replace such page on such service or any such successor service, as the case may be) for the purpose of displaying the London
interbank rates of major banks for U.S. dollars (the “LIBOR Page”) as of 11:00 A.M., London time, on that LIBOR Interest
determination date.



 


		(b)	If the rate referred to in subparagraph (a) above does not appear on the LIBOR Page by 11:00 A.M., London time, on
such LIBOR Interest determination date, LIBOR will be determined as follows:



 


(i)       Except
as provided in clause (ii) below, the Company will select four major reference banks (which may include one or more of
the initial purchasers or their affiliates) in the London interbank market and will request the principal London office of
each of those four selected banks to provide the calculation agent with such bank’s quotation of the rate at which
three-month U.S. dollar deposits, commencing on the second London business day immediately following such LIBOR Interest
determination date, are offered to prime banks in the London interbank market at approximately 11:00 A.M., London time, on
such LIBOR Interest determination date and in a principal amount of not less than $1,000,000 that is representative for a
single transaction in such market at such time.


 






    A-1-8


     


    

 


A.       If
at least two such quotations are provided, then LIBOR for such LIBOR Interest determination date will be the arithmetic mean of
such quotations.


 


B.       If
fewer than two quotations are provided, then LIBOR for such LIBOR Interest determination date will be the arithmetic mean of the
rates quoted as of approximately 11:00 A.M. in the City of New York on such LIBOR Interest determination date by three major
banks (which may include one or more of the underwriters or their affiliates) in The City of New York selected by the Company for
three-month U.S. dollar loans, commencing on the second London business day immediately following such LIBOR Interest determination
date, and in a principal amount of not less than $1,000,000 that is representative for a single transaction in such market at such
time; provided, however, that if the banks selected as aforesaid by the Company are not quoting as mentioned in this sentence,
the rate of interest in effect for the applicable period will be the same as the interest rate in effect for the immediately preceding
interest period.


 


(ii)       Notwithstanding
clause (i) above, if the Company or the Designee (as defined below) determine on or prior to the relevant LIBOR Interest determination
date that a Benchmark Transition Event and its related Benchmark Replacement Date (each, as defined below) have occurred with respect
to LIBOR (or the then-current Benchmark, as applicable), then the provisions set forth below under “Effect of Benchmark Transition
Event,” which is referred to as the benchmark transition provisions, will thereafter apply to all determinations of the rate
of interest payable on the Securities. In accordance with the benchmark transition provisions, after a Benchmark Transition Event
and its related Benchmark Replacement Date have occurred, the amount of interest that will be payable for each interest period
will be an annual rate equal to the sum of the Benchmark Replacement (as defined herein) and the margin specified herein. However,
if the Company or the Designee determine that a Benchmark Transition Event and its related Benchmark Replacement Date have occurred
with respect to the then-current Benchmark, but for any reason the Benchmark Replacement has not been determined as of the relevant
LIBOR Interest determination date, the interest rate for the applicable interest period will be equal to the interest rate for
the immediately preceding interest period, as determined by the Company or the Designee.


 


“LIBOR Interest determination date”
means the second London business day preceding each interest reset date.


 






    A-1-9


     


    

 


Effect of Benchmark Transition Event


 


If
the Company (or its designee, which may be the calculation agent only if the calculation agent consents in writing to such
appointment in its sole discretion with no liability therefor, a successor calculation agent or such other designee of the Company
(any of such entities, the “Designee”)) determines that a Benchmark Transition Event and its related Benchmark Replacement
Date have occurred prior to the Reference Time in respect of any determination of the Benchmark on any date, the Benchmark Replacement
will replace the then-current Benchmark for all purposes relating to the Securities in respect of such determination on such date
and all determinations on all subsequent dates. If the Designee is not the calculation agent, the Company shall notify the Trustee
and the calculation agent in writing of the party that has been appointed by the Company as the Designee.


 


In connection with the implementation of
a Benchmark Replacement, the Company (or the Designee) will have the right to make Benchmark Replacement Conforming Changes from
time to time.


 


Any determination, decision or election
that may be made by the Company (or the Designee) pursuant to this Section titled “Effect of Benchmark Transition Event,”
including any determination with respect to tenor, rate or adjustment or of the occurrence or non-occurrence of an event,
circumstance or date and any decision to take or refrain from taking any action or any selection, will be conclusive and binding
absent manifest error, will be made in the Company’s (or the Designee’s) sole discretion, and, notwithstanding anything
to the contrary in the documentation relating to the Securities, shall become effective without consent from the holders of the
Securities or any other party.


 


For purposes of the foregoing discussion
of the effect of Benchmark Transition Events, the following definitions are applicable:


 


“Benchmark” means, initially,
three-month LIBOR; provided that if a Benchmark Transition Event and its related Benchmark Replacement Date have occurred with
respect to three-month LIBOR or the then-current Benchmark, then “Benchmark” means the applicable Benchmark Replacement.


 


“Benchmark
Replacement” means the Interpolated Benchmark with respect to the then-current Benchmark, plus the Benchmark Replacement
Adjustment for such Benchmark; provided that if the Company (or the Designee) cannot determine the Interpolated Benchmark
as of the Benchmark Replacement Date, then “Benchmark Replacement” means the first alternative set forth in the order
below that can be determined by the Company (or the Designee) as of the Benchmark Replacement Date: (1) the sum of: (a) Term
SOFR and (b) the Benchmark Replacement Adjustment; (2) the sum of: (a) Compounded SOFR and (b) the Benchmark
Replacement Adjustment; (3) the sum of: (a) the alternate rate of interest that has been selected or recommended by the
Relevant Governmental Body as the replacement for the then-current Benchmark for the applicable Corresponding Tenor and (b) the
Benchmark Replacement Adjustment; (4) the sum of: (a) the ISDA Fallback Rate and (b) the Benchmark Replacement Adjustment;
(5) the sum of: (a) the alternate rate of interest that has been selected by the Company (or the Designee) as the replacement
for the then-current Benchmark for the applicable Corresponding Tenor giving due consideration to any industry-accepted rate of
interest as a replacement for the then-current Benchmark for U.S. dollar denominated Securities at such time and (b) the Benchmark
Replacement Adjustment.


 






    A-1-10


     


    

 


“Benchmark
Replacement Adjustment” means the first alternative set forth in the order below that can be determined by the Company (or
the Designee) as of the Benchmark Replacement Date: (1) the spread adjustment, or method for calculating or determining
such spread adjustment (which may be a positive or negative value or zero), that has been selected or recommended by the Relevant
Governmental Body for the applicable Unadjusted Benchmark Replacement; (2) if the applicable Unadjusted Benchmark Replacement
is equivalent to the ISDA Fallback Rate, then the ISDA Fallback Adjustment; (3) the spread adjustment (which may be a positive
or negative value or zero) that has been selected by the Company (or the Designee) giving due consideration to any industry-accepted
spread adjustment, or method for calculating or determining such spread adjustment, for the replacement of the then-current Benchmark
with the applicable Unadjusted Benchmark Replacement for U.S. dollar denominated Securities at such time.


 


“Benchmark Replacement Conforming
Changes” means, with respect to any Benchmark Replacement, any technical, administrative or operational changes (including
changes to the definition of “interest period”, timing and frequency of determining rates and making payments of interest,
rounding of amounts or tenors, and other administrative matters) that the Company (or the Designee) decides may be appropriate
to reflect the adoption of such Benchmark Replacement in a manner substantially consistent with market practice (or, if the Company
(or the Designee) decides that adoption of any portion of such market practice is not administratively feasible or the Company
(or the Designee) determines that no market practice for use of the Benchmark Replacement exists, in such other manner as the Company
(or the Designee) determines is reasonably necessary).


 


“Benchmark Replacement Date”
means the earliest to occur of the following events with respect to the then-current Benchmark: (1) in the case of clause
(1) or (2) of the definition of “Benchmark Transition Event,” the later of (a) the date of the public
statement or publication of information referenced therein and (b) the date on which the administrator of the Benchmark permanently
or indefinitely ceases to provide the Benchmark; or (2) in the case of clause (3) of the definition of “Benchmark
Transition Event,” the date of the public statement or publication of information referenced therein. For the avoidance of
doubt, if the event giving rise to the Benchmark Replacement Date occurs on the same day as, but earlier than, the Reference Time
in respect of any determination, the Benchmark Replacement Date will be deemed to have occurred prior to the Reference Time for
such determination.


 


“Benchmark Transition Event”
means the occurrence of one or more of the following events with respect to the then-current Benchmark: (1) a public statement
or publication of information by or on behalf of the administrator of the Benchmark announcing that such administrator has ceased
or will cease to provide the Benchmark, permanently or indefinitely, provided that, at the time of such statement or publication,
there is no successor administrator that will continue to provide the Benchmark; (2) a public statement or publication of
information by the regulatory supervisor for the administrator of the Benchmark, the central bank for the currency of the Benchmark,
an insolvency official with jurisdiction over the administrator for the Benchmark, a resolution authority with jurisdiction over
the administrator for the Benchmark or a court or an entity with similar insolvency or resolution authority over the administrator
for the Benchmark, which states that the administrator of the Benchmark has ceased or will cease to provide the Benchmark permanently
or indefinitely, provided that, at the time of such statement or publication, there is no successor administrator that will continue
to provide the Benchmark; or (3) a public statement or publication of information by the regulatory supervisor for the administrator
of the Benchmark announcing that the Benchmark is no longer representative.


 






    A-1-11


     


    

 


“Compounded SOFR” means the
compounded average of SOFRs for the applicable Corresponding Tenor, with the rate, or methodology for this rate, and conventions
for this rate being established by the Company (or the Designee) in accordance with the rate, or methodology for this rate, and
conventions for this rate selected or recommended by the Relevant Governmental Body for determining compounded SOFR; provided that
if, and to the extent that, the Company (or the Designee) determines that Compounded SOFR cannot be determined in accordance with
clause (1) above, then the rate, or methodology for this rate, and conventions for this rate that have been selected by the
Company (or the Designee) giving due consideration to any industry-accepted market practice for U.S. dollar denominated Securities
at such time. For the avoidance of doubt, the calculation of Compounded SOFR shall exclude the Benchmark Replacement Adjustment
and the margin specified herein.


 


“Corresponding Tenor” with respect
to a Benchmark Replacement means a tenor (including overnight) having approximately the same length (disregarding business day
adjustment) as the applicable tenor for the then-current Benchmark.


 


“Federal Reserve Bank of New York’s
Website” means the website of the Federal Reserve Bank of New York at http://www.newyorkfed.org, or any successor source.


 


“Interpolated Benchmark” with
respect to the Benchmark means the rate determined for the Corresponding Tenor by interpolating on a linear basis between: (1) the
Benchmark for the longest period (for which the Benchmark is available) that is shorter than the Corresponding Tenor and (2) the
Benchmark for the shortest period (for which the Benchmark is available) that is longer than the Corresponding Tenor.


 


“ISDA Definitions” means the
2006 ISDA Definitions published by the International Swaps and Derivatives Association, Inc. or any successor thereto, as
amended or supplemented from time to time, or any successor definitional booklet for interest rate derivatives published from time
to time.


 


“ISDA Fallback Adjustment” means
the spread adjustment (which may be a positive or negative value or zero) that would apply for derivatives transactions referencing
the ISDA Definitions to be determined upon the occurrence of an index cessation event with respect to the Benchmark for the applicable
tenor.


 






    A-1-12


     


    

 


“ISDA Fallback Rate” means the
rate that would apply for derivatives transactions referencing the ISDA Definitions to be effective upon the occurrence of an index
cessation date with respect to the Benchmark for the applicable tenor excluding the applicable ISDA Fallback Adjustment.


 


“Reference Time” with respect
to any determination of the Benchmark means (1) if the Benchmark is three-month LIBOR, 11:00 A.M. (London time) on the
LIBOR Interest determination date, and (2) if the Benchmark is not three-month LIBOR, the time determined by the Company (or
the Designee) in accordance with the Benchmark Replacement Conforming Changes.


 


“Relevant Governmental Body”
means the Federal Reserve Board and/or the Federal Reserve Bank of New York, or a committee officially endorsed or convened by
the Federal Reserve Board and/or the Federal Reserve Bank of New York or any successor thereto.


 


“SOFR” with respect to any day
means the secured overnight financing rate published for such day by the Federal Reserve Bank of New York, as the administrator
of the benchmark (or a successor administrator), on the Federal Reserve Bank of New York’s Website.


 


“Term SOFR” means the forward-looking
term rate for the applicable Corresponding Tenor based on SOFR that has been selected or recommended by the Relevant Governmental
Body.


 


“Unadjusted Benchmark Replacement”
means the Benchmark Replacement excluding the Benchmark Replacement Adjustment.


 


Optional Redemption


 


The Securities of this series may not be
redeemed prior to maturity.


 


Special Mandatory Redemption


 


If (i) the consummation of the Acquisition
(as defined below) does not occur on or before January 30, 2021 or (ii) the Company notifies the Trustee that the Company
will not pursue the consummation of the Acquisition (each of (i) and (ii), a “Special Mandatory Redemption Trigger”),
the Company will be required to redeem the Securities of this series then outstanding (such redemption, the “Special Mandatory
Redemption”) at a redemption price equal to 101% of the principal amount of such Securities plus accrued and unpaid interest,
if any, to, but not including, the Special Mandatory Redemption Date (the “Special Mandatory Redemption Price”).
The “Acquisition” means the acquisition by the Company of Allergan plc and its subsidiaries pursuant to the
definitive transaction agreement, dated as of June 25, 2019, by and among the Company, Venice Subsidiary LLC, a Delaware limited
liability company and a direct wholly owned subsidiary of the Company, and Allergan plc, as amended from time to time.


 






    A-1-13


     


    

 


In the event that the Company becomes obligated
to redeem the Securities of this series pursuant to the Special Mandatory Redemption, the Company will promptly, and in any event
not more than five Business Days after the date on which a Special Mandatory Redemption Trigger occurred, deliver notice to the
Trustee of the Special Mandatory Redemption and the date upon which the Securities of this series will be redeemed (the “Special
Mandatory Redemption Date,” which date shall be no later than the third Business Day following the date of such notice)
together with a notice of Special Mandatory Redemption for the Trustee to deliver to each registered holder of the Securities of
this series to be redeemed. The Trustee will then promptly mail, or electronically deliver, according to the procedures of DTC,
such notice of Special Mandatory Redemption to each registered holder of the Securities of this series to be redeemed. Unless the
Company defaults in payment of the Special Mandatory Redemption Price, on and after such Special Mandatory Redemption Date, interest
will cease to accrue on the Securities of this series to be redeemed.


 


Failure to comply in any material respect
with any obligations in the provisions described under this caption “Special Mandatory Redemption” shall constitute
an “Event of Default” under Section 5.1(7) of the Indenture.


 


Notwithstanding the foregoing, installments
of interest on the Securities of this series that are due and payable on Interest Payment Dates falling on or prior to the Special
Mandatory Redemption Date will be payable on such Interest Payment Dates to the Holder as of the close of business on the relevant
Record Dates in accordance with the Securities of this series and the Indenture.


 


For the avoidance of doubt, Article Eleven
of the Indenture shall not apply to the Special Mandatory Redemption.


 


Sinking Fund


 


The Securities of this series do not provide
for a sinking fund.


 


Default


 


If an Event of Default with respect to Securities
of this series shall occur and be continuing, the principal of the Securities of this series may be declared due and payable in
the manner and with the effect provided in the Indenture.


 


Miscellaneous


 


The Indenture contains provisions for defeasance
at any time of the entire indebtedness of this Security or certain restrictive covenants and Events of Default with respect to
this Security, in each case upon compliance with certain conditions set forth therein. Sections 13.2 and 13.3 of the Indenture
apply to the Securities of this series.


 


The Indenture permits, with certain exceptions
as therein provided, the amendment thereof and the modification of the rights and obligations of the Company and the rights of
the Holders of the Securities of each series to be affected under the Indenture at any time by the Company and the Trustee with
the consent of the Holders of not less than a majority in principal amount of the Securities at the time Outstanding of each series
to be affected. The Indenture also contains provisions permitting the Holders of specified percentages in principal amount of the
Securities at the time Outstanding of any series, on behalf of the Holders of all Securities of such series, to waive compliance
by the Company with certain provisions of the Indenture and certain past defaults under the Indenture and their consequences. Any
such consent or waiver by the Holder of this Security shall be conclusive and binding upon such Holder and upon all future Holders
of this Security and of any Security issued upon the registration of transfer hereof or in exchange herefor or in lieu hereof,
whether or not notation of such consent or waiver is made upon this Security.


 






    A-1-14


     


    

 


No reference herein to the Indenture or
Supplemental Indenture and no provision of this Security or of the Indenture or Supplemental Indenture shall alter or impair the
obligation of the Company, which is absolute and unconditional, to pay the principal of and any premium and interest on this Security
at the times, place and rate, and in the coin or currency, herein prescribed.


 


As provided in the Indenture and subject
to certain limitations therein set forth, the transfer of this Security is registerable in the Security Register, upon surrender
of this Security for registration of transfer at the office or agency of the Company in any place where the principal of and any
premium and interest on this Security are payable, duly endorsed by, or accompanied by a written instrument of transfer in form
satisfactory to the Company and the Security Registrar duly executed by, the Holder hereof or his attorney duly authorized in writing,
and thereupon one or more new Securities of this series and of like tenor, of authorized denominations and for the same aggregate
principal amount, will be issued to the designated transferee or transferees.


 


The Securities of this series are issuable
only in registered form without coupons in denominations of $2,000 and any integral multiple of $1,000 in excess thereof. As provided
in the Indenture and subject to certain limitations therein set forth, Securities of this series are exchangeable for a like aggregate
principal amount of Securities of this series and of like tenor of a different authorized denomination, as requested by the Holder
surrendering the same.


 


No service charge shall be made for any
registration of transfer or exchange of the Notes, but the Company or the Security Registrar may require payment of a sum sufficient
to cover any transfer tax, assessments, or similar governmental charge payable in connection therewith (other than any such transfer
taxes, assessments or similar governmental charge payable upon exchange or transfer pursuant to Sections 9.6 or 11.7 of the Indenture).


 


Prior to due presentment of this Security
for registration of transfer, the Company, the Trustee and any agent of the Company or the Trustee will treat the Person in whose
name this Security is registered as the owner hereof for the purpose of receiving payments and for all other purposes, whether
or not this Security be overdue, and neither the Company, the Trustee nor any such agent shall be affected by notice to the contrary.


 


All terms used in this Security which are
defined in the Indenture and Supplemental Indenture shall have the meanings assigned to them in the Indenture and Supplemental
Indenture.


 


THIS SECURITY SHALL BE GOVERNED BY AND CONSTRUED
IN ACCORDANCE WITH THE LAWS OF THE STATE OF NEW YORK.


 


This Security is a Book-Entry Security within
the meaning of the Indenture hereinafter referred to and is registered in the name of a Depository or a nominee of a Depository.
This Security is exchangeable for Securities registered in the name of a person other than the Depository or its nominee only in
the limited circumstances described in the Indenture and may not be transferred except as a whole by the Depository to a nominee
of the Depository or by a nominee of the Depository to the Depository or another nominee of the Depository.


 


*                                        
*                                        
*


 






    A-1-15


     


    

 


SCHEDULE OF EXCHANGES


 


The following exchanges, redemptions or
purchases of a part of this Book-Entry Security have been made:


 



	Date of
 Exchange/
 Redemption/
 Repurchase	Amount of

    decrease in
 Principal Amount
 of this Book-Entry
 Security 	Amount of

    increase in
 Principal Amount
 of this Book-
 Entry Security	Principal Amount

    of this Book-Entry
 Security following
 such decrease (or
 increase)	Signature of

    authorized
 signatory of
 Trustee
	 	 	 	 	 
	 	 	 	 	 
	 	 	 	 	 








 






    A-1-16


     


    

 


ASSIGNMENT FORM


 


To assign this Security, fill in the form below:


 


I or we assign and transfer this Security to


 


 


 


(Print or type assignee’s name, address
and zip code)


 


 


(Insert assignee’s soc. sec. or tax
I.D. No.)


 


and irrevocably appoint                               
as agent to transfer this Security on the books of the Company. The agent may substitute another to act for him.


 


Date:


 


Your Signature*:


 


By:


 


Name:


 


Title:


 


Sign exactly as your name appears on the
other side of this Security.


 


 


*Signature Guaranteed:


 


 


*NOTICE: The signature to this assignment must correspond with
the name as it appears upon the face of the within Note in every particular, without alteration, enlargement or any change whatever.
Such signature must be guaranteed by an “eligible guarantor institution” meeting the requirements of the Security Registrar,
which requirements include membership or participation in Security Transfer Agents Medallion Program (“STAMP”) or such
other “signature guarantee program” as may be determined by the Security Registrar in addition to, or in substitution
for, STAMP, all in accordance with the Securities Exchange Act of 1934, as amended.





 



    A-1-17


     


    




 


FORM OF TRANSFER CERTIFICATE


 


In connection with any transfer of any of
the Securities evidenced by this certificate occurring prior to the expiration of the period referred to in Rule 144 under
the Securities Act (“Rule 144”) after the later of the date of original issuance of such Notes and the last date,
if any, on which such Notes were owned by the Company or any Affiliate (as such term is defined in Rule 144) of the Company,
the undersigned confirms that such Securities are being transferred in accordance with its terms:


 


CHECK ONE BOX BELOW


 


		(1)	 ̈to the Company; or



 


		(2)	 ̈pursuant to an effective registration statement under the Securities Act;
or



 


		(3)	 ̈inside the United States to a person reasonably believed to be a “qualified
institutional buyer” (as defined in Rule 144A under the Securities Act) that purchases for its own account or for the
account of a qualified institutional buyer to whom notice is given that such transfer is being made in reliance on Rule 144A,
in each case pursuant to and in compliance with Rule 144A under the Securities Act; or



 


		(4)	 ̈in an offshore transaction in compliance with Rule 903 or Rule 904
of Regulation S under the Securities Act; or



 


		(5)	 ̈pursuant to the exemption from registration provided by Rule 144
under the Securities Act or any other available exemption from the registration requirement of the Securities Act.



 


Unless one of the boxes is checked,
the Trustee shall refuse to register any of the Securities evidenced by this certificate in the name of any person other than the
registered holder thereof; provided, however, that if box (5) is checked, the Trustee shall be entitled to require, prior
to registering any such transfer of the Securities, such legal opinions, certifications and other information as the Company has
reasonably requested to confirm that such transfer is being made pursuant to an exemption from, or in a transaction not subject
to, the registration requirements of the Securities Act.


 


 


	 	 
	 	Signature


 






    A-1-18


     


    

 


TO BE COMPLETED BY PURCHASER IF (3) ABOVE
IS CHECKED.


 


The undersigned represents and warrants that it is purchasing
this Security for its own account or an account with respect to which it exercises sole investment discretion and that it and any
such account is a “qualified institutional buyer” within the meaning of Rule 144A under the Securities Act, and
is aware that the sale to it is being made in reliance on Rule 144A and acknowledges that it has received such information
regarding the Company as the undersigned has requested pursuant to Rule 144A or has determined not to request such information
and that it is aware that the transferor is relying upon the undersigned’s foregoing representations in order to claim the
exemption from registration provided by Rule 144A.


 


	Dated:	 	 	Notice: 	To be executed by an executive
officer


 






    A-1-19


     


    

  


FORM OF EXCHANGE CERTIFICATE


 


AbbVie Inc.


1 North Waukegan Road


North Chicago, Illinois
60064


 


U.S. Bank National Association


190 South LaSalle Street, 10th Floor


Chicago, IL 60603


Attention: Corporate Trust Services


 


Re: Senior Floating Rate Notes
due May 2021


 


Reference is hereby made to the Indenture,
dated as of November 8, 2012 (the “Base Indenture”), as supplemented by the First Supplemental Indenture, dated
as of November 8, 2012, the Second Supplemental Indenture, dated as of May 14, 2015, the Third Supplemental Indenture,
dated as of May 12, 2016, the Fourth Supplemental Indenture, dated as of November 17, 2016, the Fifth Supplemental Indenture,
dated as of September 18, 2018, the Sixth Supplemental Indenture, dated as of September 26, 2019 and the Seventh Supplemental
Indenture, dated as of November 21, 2019 (as so supplemented, the “Indenture”), between AbbVie Inc. (the “Company”)
and U.S. Bank National Association, a national banking association as trustee. Capitalized terms used but not defined herein shall
have the meanings given to them in the Indenture.


 


_____________(the “Owner”)
owns and proposes to exchange the Security[ies] or interest in such Security[ies] specified herein, in the principal amount
of $ __________ in such Security[ies] or interests (the “Exchange”). In connection with the Exchange, the Owner
hereby certifies that in connection with the Exchange of the Owner’s Regulation S Global Note for a beneficial interest
in the Rule 144A Global Note, with an equal principal amount, the Security[ies] or interest in such Security[ies]
specified herein [is][are] being transferred to a Person (A) who the transferor reasonably believes to be a QIB,
(B) purchasing for its own account or the account of a QIB in a transaction meeting the requirements of Rule 144A,
and (C) in accordance with all applicable securities laws of the States of the United States and other
jurisdictions.


 


This certificate and the statements contained
herein are made for your benefit and the benefit of the Company and are dated _________________.


 


	 	[Insert Name of Transferor]
	 	 
	 	By:	 
	 	 	Name:
	 	 	Title:
	 	 	 
	 	 	 
	 	 	 
	Dated:	 	 	 	 
	 	 	 	 	 


 






    A-1-20


     


    

 



EXHIBIT A2


 


(FORM OF FACE OF INITIAL NOTE)


 


[THIS SECURITY IS A GLOBAL SECURITY WITHIN THE MEANING OF THE
INDENTURE HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME OF A DEPOSITARY OR A NOMINEE OF A DEPOSITARY. UNLESS AND UNTIL
IT IS EXCHANGED IN WHOLE OR IN PART FOR SECURITIES IN DEFINITIVE FORM IN ACCORDANCE WITH THE PROVISIONS OF THE INDENTURE AND THE
TERMS OF THE SECURITIES, TRANSFERS OF THIS GLOBAL SECURITY SHALL BE LIMITED TO TRANSFERS IN WHOLE, BUT NOT IN PART, TO THE DEPOSITORY
TRUST COMPANY, A NEW YORK CORPORATION (“DTC”), TO NOMINEES OF DTC OR TO A SUCCESSOR THEREOF OR SUCH SUCCESSOR’S
NOMINEE AND TRANSFERS OF PORTIONS OF THIS GLOBAL SECURITY SHALL BE LIMITED TO TRANSFERS MADE IN ACCORDANCE WITH THE RESTRICTIONS
SET FORTH IN THE INDENTURE REFERRED TO ON THE REVERSE HEREOF.


 


UNLESS THIS CERTIFICATE IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE
OF DTC, TO ABBVIE INC., OR ITS AGENT FOR REGISTRATION OF TRANSFER, EXCHANGE OR PAYMENT, AND ANY CERTIFICATE ISSUED IS REGISTERED
IN THE NAME OF CEDE & CO. OR IN SUCH OTHER NAME AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC (AND ANY PAYMENT IS
MADE TO CEDE & CO. OR TO SUCH OTHER ENTITY AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC), ANY TRANSFER, PLEDGE OR
OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL INASMUCH AS THE REGISTERED OWNER HEREOF, CEDE & CO.,
HAS AN INTEREST HEREIN.](1)


 


THIS SECURITY HAS NOT BEEN REGISTERED UNDER THE SECURITIES ACT
OF 1933, AS AMENDED (THE “SECURITIES ACT”), OR THE SECURITIES LAWS OF ANY STATE OR OTHER JURISDICTION.


 


NEITHER THIS SECURITY NOR ANY INTEREST OR PARTICIPATION
HEREIN MAY BE REOFFERED, SOLD, ASSIGNED, TRANSFERRED, PLEDGED, ENCUMBERED OR OTHERWISE DISPOSED OF IN THE ABSENCE OF SUCH
REGISTRATION OR UNLESS SUCH TRANSACTION IS EXEMPT FROM, OR NOT SUBJECT TO, SUCH REGISTRATION. THE HOLDER OF THIS SECURITY, BY
ITS ACCEPTANCE HEREOF, AGREES ON ITS OWN BEHALF AND ON BEHALF OF ANY INVESTOR ACCOUNT FOR WHICH IT HAS PURCHASED SECURITIES,
TO OFFER, SELL OR OTHERWISE TRANSFER SUCH SECURITY, PRIOR TO THE DATE (THE “RESALE RESTRICTION TERMINATION DATE”)
THAT IS [IN THE CASE OF RULE 144A NOTES: ONE YEAR] [IN THE CASE OF REGULATION S NOTES: 40 DAYS] AFTER THE LATER OF THE ISSUE
DATE HEREOF OR ANY OTHER ISSUE DATE IN RESPECT OF A FURTHER ISSUANCE OF SECURITIES OF THE SAME SERIES AND THE LAST DATE ON
WHICH ABBVIE INC. OR ANY AFFILIATE OF ABBVIE INC. WAS THE OWNER OF THIS SECURITY (OR ANY PREDECESSOR OF SUCH SECURITY), ONLY
(A) TO ABBVIE INC. OR ANY SUBSIDIARY THEREOF, (B) PURSUANT TO A REGISTRATION STATEMENT THAT HAS BEEN DECLARED
EFFECTIVE UNDER THE SECURITIES ACT, (C) FOR SO LONG AS THE SECURITIES ARE ELIGIBLE FOR RESALE PURSUANT TO RULE 144A
UNDER THE SECURITIES ACT (“RULE 144A”), TO A PERSON IT REASONABLY BELIEVES IS A ‘‘QUALIFIED
INSTITUTIONAL BUYER’’ AS DEFINED IN RULE 144A THAT PURCHASES FOR ITS OWN ACCOUNT OR FOR THE ACCOUNT OF A
QUALIFIED INSTITUTIONAL BUYER TO WHOM NOTICE IS GIVEN THAT THE TRANSFER IS BEING MADE IN RELIANCE ON RULE 144A IN A
TRANSACTION MEETING THE REQUIREMENTS OF RULE 144A, (D) PURSUANT TO OFFERS AND SALES TO NON-U.S. PERSONS THAT OCCUR
OUTSIDE THE UNITED STATES WITHIN THE MEANING OF REGULATION S UNDER THE SECURITIES ACT, (E) TO AN INSTITUTIONAL
 “ACCREDITED INVESTOR” WITHIN THE MEANING OF RULE 501(a)(1), (2), (3) OR (7) UNDER THE SECURITIES ACT THAT IS
NOT A QUALIFIED INSTITUTIONAL BUYER AND THAT IS PURCHASING FOR ITS OWN ACCOUNT OR FOR THE ACCOUNT OF ANOTHER INSTITUTIONAL
ACCREDITED INVESTOR, IN EACH CASE IN A MINIMUM PRINCIPAL AMOUNT OF THE SECURITIES OF $250,000, FOR INVESTMENT PURPOSES AND
NOT WITH A VIEW TO OR FOR OFFER OR SALE IN CONNECTION WITH ANY DISTRIBUTION IN VIOLATION OF THE SECURITIES ACT
OR (F) PURSUANT TO ANOTHER AVAILABLE EXEMPTION FROM THE REGISTRATION REQUIREMENTS OF THE SECURITIES ACT, SUBJECT TO
ABBVIE INC.’S AND THE TRUSTEE’S RIGHT PRIOR TO ANY SUCH OFFER, SALE OR TRANSFER PURSUANT TO CLAUSES (D), (E)
OR (F) TO REQUIRE THE DELIVERY OF AN OPINION OF COUNSEL, CERTIFICATION AND/OR OTHER INFORMATION SATISFACTORY TO EACH OF
THEM.


 






    	 	 A-2-1 	 



     


    

 


[EACH PURCHASER OF THIS SECURITY IS HEREBY NOTIFIED THAT THE
SELLER OF THIS SECURITY MAY BE RELYING ON THE EXEMPTION FROM THE PROVISIONS OF SECTION 5 OF THE SECURITIES ACT PROVIDED BY
RULE 144A THEREUNDER.](2)


 


[BY ITS ACQUISITION HEREOF, THE HOLDER HEREOF REPRESENTS THAT
IT IS NOT A U.S. PERSON NOR IS IT PURCHASING FOR THE ACCOUNT OF A U.S. PERSON AND IS ACQUIRING THIS SECURITY IN AN OFFSHORE TRANSACTION
IN ACCORDANCE WITH REGULATION S UNDER THE SECURITIES ACT.](3)


 


[IN CONNECTION WITH ANY TRANSFER, THE HOLDER
WILL DELIVER TO THE REGISTRAR AND TRANSFER AGENT SUCH CERTIFICATES AND OTHER INFORMATION AS SUCH TRANSFER AGENT MAY REASONABLY
REQUIRE TO CONFIRM THAT THE TRANSFER COMPLIES WITH THE FOREGOING RESTRICTIONS.](4)


 





 



(1) Applies to Global Notes only


 


(2) Applies to Rule 144A Notes only


 


(3) Applies to Regulation S Notes only


 


(4) Applies to Notes in definitive form
only


 




    A-2-2


     


    


 


ABBVIE INC.


 


Senior Floating Rate Notes due November
2021


 


	No. [●]	$[●]
	 	 
	CUSIP No: [●]	 
	 	 
	ISIN No: [●]	 




 


ABBVIE INC., a corporation duly organized
and existing under the laws of Delaware (herein called the “Company,” which term includes any successor Person
under the Indenture and Supplemental Indenture hereinafter referred to), for value received, hereby promises to pay to Cede &
Co., as nominee for The Depository Trust Company, or registered assigns, the principal sum of [●] Dollars ($[●]), or
such other principal sum as may be indicated on the Schedule of Exchanges attached hereto, on November 19, 2021 (the “Maturity
Date”), and to pay interest thereon from November 21, 2019 (the “Original Issue Date”) or from the
most recent Interest Payment Date (as defined below) to which interest has been paid or duly provided for, quarterly in arrears
on February 19, May 19, August 19 and November 19 of each year, commencing on February 19, 2020, subject to adjustment as provided
below (each, an “Interest Payment Date”), at a rate equal to the Benchmark (as defined on the reverse hereof),
which will initially be three-month LIBOR (as defined on the reverse hereof) plus 46 basis points and reset (as provided on the
reverse hereof) on each February 19, May 19, August 19 and November 19 (each, an “Interest Reset Date”) after
the Original Issue Date until the principal hereof is paid or made available for payment. Interest payments on this Security will
include interest accrued to but excluding the Interest Payment Date or Maturity Date, as the case may be. The interest so payable,
and punctually paid or duly provided for, on any Interest Payment Date will, as provided in such Indenture, be paid to the Person
in whose name this Security (or one or more Predecessor Securities) is registered at the close of business on the Regular Record
Date for such interest, which shall be the date that is 15 calendar days prior to the relevant Interest Payment Date (whether or
not such record date is a Business Day); provided, however, that interest payable at maturity of this Note shall be payable to
the persons to whom principal shall be payable, subject to DTC’s applicable procedures. Any such interest not so punctually
paid or duly provided for will forthwith cease to be payable to the Holder on such Regular Record Date and may either be paid to
the Person in whose name this Security (or one or more Predecessor Securities) is registered at the close of business on a Special
Record Date for the payment of such Defaulted Interest to be fixed by the Trustee, notice whereof shall be given to Holders of
Securities of this series not less than 10 days prior to such Special Record Date, or be paid at any time in any other lawful manner
not inconsistent with the requirements of any securities exchange on which the Securities of this series may be listed, and upon
such notice as may be required by such exchange, all as more fully provided in said Indenture.


 


If any Interest Reset Date for this
Security would otherwise be a day that is not a Business Day, such Interest Reset Date will be the next succeeding day that
is a Business Day, except that if the Business Day is in the next succeeding calendar month, the Interest Reset Date will be
the immediately preceding day that is a Business Day. “Business Day” means any calendar day that is not a
Saturday, Sunday or legal holiday in New York, New York and on which commercial banks are open for business in New York, New
York. If any Interest Payment Date (other than an interest payment date occurring on the Maturity Date) falls on a day that
is not a Business Day, such Interest Payment Date will be the following day that is a Business Day, except that, if the
Business Day is in the next succeeding calendar month, the Interest Payment Date shall be the immediately preceding day that
is a Business Day (in each case, resulting in a corresponding adjustment to the number of days in the applicable interest
period). If the Maturity Date falls on a day that is not a Business Day, the payment of principal and interest may be made on
the next succeeding Business Day, and no interest on that payment shall accrue for the period from and after such
maturity.


 






    A-2-3


     


    

 


Accrued interest is calculated by multiplying
the face amount by an accrued interest factor. The accrued interest factor is computed by adding the interest factor calculated
for each day from the Original Issue Date, or from, and including, the last Interest Payment Date, to, but excluding, the date
for which accrued interest is being calculated. The “interest factor” for each day is computed by dividing the interest
rate applicable to that day by 360. All percentages resulting from any calculation will be rounded, if necessary, to the nearest
one hundred-thousandth of a percentage point, with five one-millionths of a percentage point rounded upward (e.g., 9.876545% (or
..09876545) will be rounded upward to 9.87655% (or .0987655)), and all amounts used in or resulting from the calculation will be
rounded to the nearest cent (with one-half cent being rounded upward).


 


The calculation of the interest rate on
this Security will be made by U.S. Bank National Association, as “calculation agent.” If at any time the Trustee (as
defined on the reverse hereof) is not also the calculation agent, the Company will notify (or cause the calculation agent to notify)
the Trustee of each determination of the interest rate promptly after the determination is made by any successor calculation agent.
All calculations made by the calculation agent shall in the absence of manifest error be conclusive for all purposes and binding
on the Company, the Trustee and the Holder. Upon the request of the Holder, the Trustee will provide the interest rate then in
effect and, if determined, the interest rate that will become effective as a result of a determination made for the next Interest
Reset Date. The interest rate on this Security will in no event be higher than the maximum rate permitted by New York law, as the
same may be modified by United States law of general application.


 


Payment of the principal of (and
premium, if any) and any such interest on this Security will be made at the office or agency of the Company maintained for
that purpose in St. Paul, Minnesota, in such coin or currency of the United States of America as at the time of payment is
legal tender for payment of public and private debts; provided, however, that at the option of the Company payment of
interest may be made by (1) check mailed to the address of the Person entitled thereto as such address shall appear in
the Security Register or (2) wire transfer as directed by the Holder, in immediately available funds to an account
maintained by the Depository or its nominee with respect to a Global Note, and to the Holder or its nominee with respect to a
Definitive Note; provided further that in the case of a Definitive Note (1) the Holder thereof shall have provided
written wiring instructions to the Trustee on or before the related Regular Record Date and (2) if appropriate
instructions for any such wire transfer are not received by the related Regular Record Date, then such payment shall be made
by check mailed to the address of the Holder specified in the Security Register.


 






    A-2-4


     


    

 


Reference is hereby made to the further
provisions of this Security set forth on the reverse hereof, which further provisions shall for all purposes have the same effect
as if set forth at this place.


 


Unless the certificate of authentication
hereon has been executed by the Trustee referred to herein by manual signature, this Security shall not be entitled to any benefit
under the Indenture or be valid or obligatory for any purpose.


 




    A-2-5


     


    


 


IN WITNESS WHEREOF, the Company has caused
this instrument to be duly executed.


 


Dated: November 21, 2019


 





	 	ABBVIE INC.
	 	 
	 	By:	 
	 	 	Name:	 
	 	 	Title:	 






 




    A-2-6


     


    


 


TRUSTEE’S CERTIFICATE OF AUTHENTICATION


 


This is one of the Securities of the series
designated therein referred to in the within-mentioned Indenture.


 


Dated: November 21, 2019


 


	 	U.S. BANK NATIONAL ASSOCIATION,
	 	as Trustee
	 	 
	 	By:
	 	Authorized Signatory





 












    A-2-7


     


    

 


[FORM OF REVERSE OF SECURITY]


 


This Security is one of a duly authorized
issue of securities of the Company (herein called the “Securities”), issued and to be issued in one or more
series under an Indenture, dated as of November 8, 2012, as it may be supplemented or amended from time to time (herein called
the “Indenture”), between the Company and U.S. Bank National Association, as Trustee (herein called the “Trustee,”
which term includes any successor trustee under the Indenture), and Supplemental Indenture No. 7, dated as of November 21,
2019 (herein called the “Supplemental Indenture”), between the Company and the Trustee, to which Indenture,
Supplemental Indenture and all indentures supplemental thereto reference is hereby made for a statement of the respective rights,
limitations of rights, duties and immunities thereunder of the Company, the Trustee and the Holders of the Securities of this series
and of the terms upon which the Securities of this series are, and are to be, authenticated and delivered. This Security is one
of the series designated on the face hereof, in an initial aggregate principal amount of $[●].


 


Interest


 


The interest rate in effect with respect
to the Securities of this series on each day that is not an Interest Reset Date will be the interest rate determined as of the
LIBOR Interest determination date (as defined below) pertaining to the immediately preceding Interest Reset Date and the interest
rate in effect on any day that is an Interest Reset Date will be the interest rate determined as of the LIBOR Interest determination
date pertaining to that Interest Reset Date, subject in either case to applicable provisions of law.


 


“LIBOR”
means the rate determined in accordance with the following provisions:


 


		(a)	With respect to a LIBOR Interest determination date, LIBOR will be the rate for deposits in
U.S. dollars having a maturity of three months, commencing on the first day of the applicable interest period immediately following
that LIBOR Interest determination date, that appears on the display on Reuters (or any successor service) on the LIBOR 01 page
(or any other page as may replace such page on such service or any such successor service, as the case may be) for the purpose
of displaying the London interbank rates of major banks for U.S. dollars (the “LIBOR Page”) as of 11:00 A.M., London
time, on that LIBOR Interest determination date.



 


		(b)	If the rate referred to in subparagraph (a) above does not appear on the LIBOR Page by 11:00
A.M., London time, on such LIBOR Interest determination date, LIBOR will be determined as follows:



 


(i)              Except
as provided in clause (ii) below, the Company will select four major reference banks (which may include one or more of the initial
purchasers or their affiliates) in the London interbank market and will request the principal London office of each of those four
selected banks to provide the calculation agent with such bank’s quotation of the rate at which three-month U.S. dollar
deposits, commencing on the second London business day immediately following such LIBOR Interest determination date, are offered
to prime banks in the London interbank market at approximately 11:00 A.M., London time, on such LIBOR Interest determination date
and in a principal amount of not less than $1,000,000 that is representative for a single transaction in such market at such time.


 






    A-2-8


     


    

 


A.            If
at least two such quotations are provided, then LIBOR for such LIBOR Interest determination date will be the arithmetic mean of
such quotations.


 


B.            If
fewer than two quotations are provided, then LIBOR for such LIBOR Interest determination date will be the arithmetic mean of the
rates quoted as of approximately 11:00 A.M. in the City of New York on such LIBOR Interest determination date by three major banks
(which may include one or more of the underwriters or their affiliates) in The City of New York selected by the Company for three-month
U.S. dollar loans, commencing on the second London business day immediately following such LIBOR Interest determination date,
and in a principal amount of not less than $1,000,000 that is representative for a single transaction in such market at such time;
provided, however, that if the banks selected as aforesaid by the Company are not quoting as mentioned in this sentence, the rate
of interest in effect for the applicable period will be the same as the interest rate in effect for the immediately preceding
interest period.


 


(ii)             Notwithstanding
clause (i) above, if the Company or the Designee (as defined below) determine on or prior to the relevant LIBOR Interest determination
date that a Benchmark Transition Event and its related Benchmark Replacement Date (each, as defined below) have occurred with
respect to LIBOR (or the then-current Benchmark, as applicable), then the provisions set forth below under “Effect of Benchmark
Transition Event,” which is referred to as the benchmark transition provisions, will thereafter apply to all determinations
of the rate of interest payable on the Securities. In accordance with the benchmark transition provisions, after a Benchmark Transition
Event and its related Benchmark Replacement Date have occurred, the amount of interest that will be payable for each interest
period will be an annual rate equal to the sum of the Benchmark Replacement (as defined herein) and the margin specified herein.
However, if the Company or the Designee determine that a Benchmark Transition Event and its related Benchmark Replacement Date
have occurred with respect to the then-current Benchmark, but for any reason the Benchmark Replacement has not been determined
as of the relevant LIBOR Interest determination date, the interest rate for the applicable interest period will be equal to the
interest rate for the immediately preceding interest period, as determined by the Company or the Designee.


 




    A-2-9


     


    


 


“LIBOR
Interest determination date” means the second London business day preceding each interest reset date.


 


Effect of Benchmark Transition Event


 


If the
Company (or its designee, which may be the calculation agent only if the calculation agent consents in writing to such appointment
in its sole discretion with no liability therefor, a successor calculation agent or such other designee of the Company (any of
such entities, the “Designee”)) determines that a Benchmark Transition Event and its related Benchmark Replacement
Date have occurred prior to the Reference Time in respect of any determination of the Benchmark on any date, the Benchmark Replacement
will replace the then-current Benchmark for all purposes relating to the Securities in respect of such determination on such date
and all determinations on all subsequent dates. If the Designee is not the calculation agent, the Company shall notify the Trustee
and the calculation agent in writing of the party that has been appointed by the Company as the Designee.


 


In connection
with the implementation of a Benchmark Replacement, the Company (or the Designee) will have the right to make Benchmark Replacement
Conforming Changes from time to time.


 


Any determination,
decision or election that may be made by the Company (or the Designee) pursuant to this Section titled “Effect of Benchmark
Transition Event,” including any determination with respect to tenor, rate or adjustment or of the occurrence or non-occurrence of
an event, circumstance or date and any decision to take or refrain from taking any action or any selection, will be conclusive
and binding absent manifest error, will be made in the Company’s (or the Designee’s) sole discretion, and, notwithstanding
anything to the contrary in the documentation relating to the Securities, shall become effective without consent from the holders
of the Securities or any other party. 


 


For purposes of the foregoing discussion
of the effect of Benchmark Transition Events, the following definitions are applicable:


 


“Benchmark”
means, initially, three-month LIBOR; provided that if a Benchmark Transition Event and its related Benchmark Replacement Date have
occurred with respect to three-month LIBOR or the then-current Benchmark, then “Benchmark” means the applicable Benchmark
Replacement.


 


“Benchmark
Replacement” means the Interpolated Benchmark with respect to the then-current Benchmark, plus the Benchmark Replacement
Adjustment for such Benchmark; provided that if the Company (or the Designee) cannot determine the Interpolated Benchmark as of
the Benchmark Replacement Date, then “Benchmark Replacement” means the first alternative set forth in the order below
that can be determined by the Company (or the Designee) as of the Benchmark Replacement Date: (1) the sum of: (a) Term SOFR and
(b) the Benchmark Replacement Adjustment; (2) the sum of: (a) Compounded SOFR and (b) the Benchmark Replacement Adjustment; (3)
the sum of: (a) the alternate rate of interest that has been selected or recommended by the Relevant Governmental Body as the
replacement for the then-current Benchmark for the applicable Corresponding Tenor and (b) the Benchmark Replacement Adjustment;
(4) the sum of: (a) the ISDA Fallback Rate and (b) the Benchmark Replacement Adjustment; (5) the sum of: (a) the alternate rate
of interest that has been selected by the Company (or the Designee) as the replacement for the then-current Benchmark for the
applicable Corresponding Tenor giving due consideration to any industry-accepted rate of interest as a replacement for the then-current
Benchmark for U.S. dollar denominated Securities at such time and (b) the Benchmark Replacement Adjustment.


 






    A-2-10


     


    

 


“Benchmark Replacement Adjustment”
means the first alternative set forth in the order below that can be determined by the Company (or the Designee) as of the Benchmark
Replacement Date: (1) the spread adjustment, or method for calculating or determining such spread adjustment (which may be a positive
or negative value or zero), that has been selected or recommended by the Relevant Governmental Body for the applicable Unadjusted
Benchmark Replacement; (2) if the applicable Unadjusted Benchmark Replacement is equivalent to the ISDA Fallback Rate, then the
ISDA Fallback Adjustment; (3) the spread adjustment (which may be a positive or negative value or zero) that has been selected
by the Company (or the Designee) giving due consideration to any industry-accepted spread adjustment, or method for calculating
or determining such spread adjustment, for the replacement of the then-current Benchmark with the applicable Unadjusted Benchmark
Replacement for U.S. dollar denominated Securities at such time.


 


“Benchmark Replacement Conforming
Changes” means, with respect to any Benchmark Replacement, any technical, administrative or operational changes (including
changes to the definition of “interest period”, timing and frequency of determining rates and making payments of interest,
rounding of amounts or tenors, and other administrative matters) that the Company (or the Designee) decides may be appropriate
to reflect the adoption of such Benchmark Replacement in a manner substantially consistent with market practice (or, if the Company
(or the Designee) decides that adoption of any portion of such market practice is not administratively feasible or the Company
(or the Designee) determines that no market practice for use of the Benchmark Replacement exists, in such other manner as the Company
(or the Designee) determines is reasonably necessary).


 


“Benchmark Replacement Date”
means the earliest to occur of the following events with respect to the then-current Benchmark: (1) in the case of clause (1) or
(2) of the definition of “Benchmark Transition Event,” the later of (a) the date of the public statement or publication
of information referenced therein and (b) the date on which the administrator of the Benchmark permanently or indefinitely ceases
to provide the Benchmark; or (2) in the case of clause (3) of the definition of “Benchmark Transition Event,” the date
of the public statement or publication of information referenced therein. For the avoidance of doubt, if the event giving rise
to the Benchmark Replacement Date occurs on the same day as, but earlier than, the Reference Time in respect of any determination,
the Benchmark Replacement Date will be deemed to have occurred prior to the Reference Time for such determination.


 


“Benchmark Transition Event”
means the occurrence of one or more of the following events with respect to the then-current Benchmark: (1) a public statement
or publication of information by or on behalf of the administrator of the Benchmark announcing that such administrator has ceased
or will cease to provide the Benchmark, permanently or indefinitely, provided that, at the time of such statement or publication,
there is no successor administrator that will continue to provide the Benchmark; (2) a public statement or publication of information
by the regulatory supervisor for the administrator of the Benchmark, the central bank for the currency of the Benchmark, an insolvency
official with jurisdiction over the administrator for the Benchmark, a resolution authority with jurisdiction over the administrator
for the Benchmark or a court or an entity with similar insolvency or resolution authority over the administrator for the Benchmark,
which states that the administrator of the Benchmark has ceased or will cease to provide the Benchmark permanently or indefinitely,
provided that, at the time of such statement or publication, there is no successor administrator that will continue to provide
the Benchmark; or (3) a public statement or publication of information by the regulatory supervisor for the administrator of the
Benchmark announcing that the Benchmark is no longer representative.


 






    A-2-11


     


    

 


“Compounded SOFR” means the
compounded average of SOFRs for the applicable Corresponding Tenor, with the rate, or methodology for this rate, and conventions
for this rate being established by the Company (or the Designee) in accordance with the rate, or methodology for this rate, and
conventions for this rate selected or recommended by the Relevant Governmental Body for determining compounded SOFR; provided that
if, and to the extent that, the Company (or the Designee) determines that Compounded SOFR cannot be determined in accordance with
clause (1) above, then the rate, or methodology for this rate, and conventions for this rate that have been selected by the Company
(or the Designee) giving due consideration to any industry-accepted market practice for U.S. dollar denominated Securities at such
time. For the avoidance of doubt, the calculation of Compounded SOFR shall exclude the Benchmark Replacement Adjustment and the
margin specified herein.


 


“Corresponding Tenor” with respect
to a Benchmark Replacement means a tenor (including overnight) having approximately the same length (disregarding business day
adjustment) as the applicable tenor for the then-current Benchmark.


 


“Federal Reserve Bank of New York’s
Website” means the website of the Federal Reserve Bank of New York at http://www.newyorkfed.org, or any successor source.


 


“Interpolated Benchmark” with
respect to the Benchmark means the rate determined for the Corresponding Tenor by interpolating on a linear basis between: (1)
the Benchmark for the longest period (for which the Benchmark is available) that is shorter than the Corresponding Tenor and (2)
the Benchmark for the shortest period (for which the Benchmark is available) that is longer than the Corresponding Tenor.


 


“ISDA Definitions” means the
2006 ISDA Definitions published by the International Swaps and Derivatives Association, Inc. or any successor thereto, as amended
or supplemented from time to time, or any successor definitional booklet for interest rate derivatives published from time to time.


 


“ISDA Fallback Adjustment” means
the spread adjustment (which may be a positive or negative value or zero) that would apply for derivatives transactions referencing
the ISDA Definitions to be determined upon the occurrence of an index cessation event with respect to the Benchmark for the applicable
tenor.


 




    A-2-12


     


    


 


“ISDA Fallback Rate” means the
rate that would apply for derivatives transactions referencing the ISDA Definitions to be effective upon the occurrence of an index
cessation date with respect to the Benchmark for the applicable tenor excluding the applicable ISDA Fallback Adjustment.


 


“Reference Time” with respect
to any determination of the Benchmark means (1) if the Benchmark is three-month LIBOR, 11:00 A.M. (London time) on the LIBOR Interest
determination date, and (2) if the Benchmark is not three-month LIBOR, the time determined by the Company (or the Designee) in
accordance with the Benchmark Replacement Conforming Changes.


 


“Relevant Governmental Body”
means the Federal Reserve Board and/or the Federal Reserve Bank of New York, or a committee officially endorsed or convened by
the Federal Reserve Board and/or the Federal Reserve Bank of New York or any successor thereto.


 


“SOFR” with respect to any day
means the secured overnight financing rate published for such day by the Federal Reserve Bank of New York, as the administrator
of the benchmark (or a successor administrator), on the Federal Reserve Bank of New York’s Website.


 


“Term SOFR” means the forward-looking
term rate for the applicable Corresponding Tenor based on SOFR that has been selected or recommended by the Relevant Governmental
Body.


 


“Unadjusted Benchmark Replacement”
means the Benchmark Replacement excluding the Benchmark Replacement Adjustment.


 


Optional Redemption 


 


The Securities of this series may not be
redeemed prior to maturity.


 


Special Mandatory Redemption 


 


If (i)
the consummation of the Acquisition (as defined below) does not occur on or before January 30, 2021 or (ii) the Company notifies
the Trustee that the Company will not pursue the consummation of the Acquisition (each of (i) and (ii), a “Special Mandatory
Redemption Trigger”), the Company will be required to redeem the Securities of this series then outstanding (such redemption,
the “Special Mandatory Redemption”) at a redemption price equal to 101% of the principal amount of such Securities
plus accrued and unpaid interest, if any, to, but not including, the Special Mandatory Redemption Date (the “Special Mandatory
Redemption Price”). The “Acquisition” means the acquisition by the Company of Allergan plc and its
subsidiaries pursuant to the definitive transaction agreement, dated as of June 25, 2019, by and among the Company, Venice Subsidiary
LLC, a Delaware limited liability company and a direct wholly owned subsidiary of the Company, and Allergan plc, as amended from
time to time.


 






    A-2-13


     


    

 


In
the event that the Company becomes obligated to redeem the Securities of this series pursuant to the Special Mandatory
Redemption, the Company will promptly, and in any event not more than five Business Days after the date on which a Special
Mandatory Redemption Trigger occurred, deliver notice to the Trustee of the Special Mandatory Redemption and the date upon
which the Securities of this series will be redeemed (the “Special Mandatory Redemption Date,” which date
shall be no later than the third Business Day following the date of such notice) together with a notice of Special Mandatory
Redemption for the Trustee to deliver to each registered holder of the Securities of this series to be redeemed. The Trustee
will then promptly mail, or electronically deliver, according to the procedures of DTC, such notice of Special Mandatory
Redemption to each registered holder of the Securities of this series to be redeemed. Unless the Company defaults in payment
of the Special Mandatory Redemption Price, on and after such Special Mandatory Redemption Date, interest will cease to accrue
on the Securities of this series to be redeemed.


 


Failure to comply in any material respect
with any obligations in the provisions described under this caption “Special Mandatory Redemption” shall constitute
an “Event of Default” under Section 5.1(7) of the Indenture.


 


Notwithstanding the foregoing, installments
of interest on the Securities of this series that are due and payable on Interest Payment Dates falling on or prior to the Special
Mandatory Redemption Date will be payable on such Interest Payment Dates to the Holder as of the close of business on the relevant
Record Dates in accordance with the Securities of this series and the Indenture.


 


For the avoidance of doubt, Article Eleven
of the Indenture shall not apply to the Special Mandatory Redemption.


 


Sinking Fund 


 


The Securities of this series do not provide
for a sinking fund.


 


Default


 


If an Event of Default with respect to Securities
of this series shall occur and be continuing, the principal of the Securities of this series may be declared due and payable in
the manner and with the effect provided in the Indenture.


 


Miscellaneous 


 


The Indenture contains provisions for defeasance
at any time of the entire indebtedness of this Security or certain restrictive covenants and Events of Default with respect to
this Security, in each case upon compliance with certain conditions set forth therein. Sections 13.2 and 13.3 of the Indenture
apply to the Securities of this series.


 


The Indenture permits, with certain
exceptions as therein provided, the amendment thereof and the modification of the rights and obligations of the Company and
the rights of the Holders of the Securities of each series to be affected under the Indenture at any time by the Company and
the Trustee with the consent of the Holders of not less than a majority in principal amount of the Securities at the time
Outstanding of each series to be affected. The Indenture also contains provisions permitting the Holders of specified
percentages in principal amount of the Securities at the time Outstanding of any series, on behalf of the Holders of all
Securities of such series, to waive compliance by the Company with certain provisions of the Indenture and certain past
defaults under the Indenture and their consequences. Any such consent or waiver by the Holder of this Security shall be
conclusive and binding upon such Holder and upon all future Holders of this Security and of any Security issued upon the
registration of transfer hereof or in exchange herefor or in lieu hereof, whether or not notation of such consent or waiver
is made upon this Security.


 






    A-2-14


     


    

 


No reference herein to the Indenture or
Supplemental Indenture and no provision of this Security or of the Indenture or Supplemental Indenture shall alter or impair the
obligation of the Company, which is absolute and unconditional, to pay the principal of and any premium and interest on this Security
at the times, place and rate, and in the coin or currency, herein prescribed.


 


As provided in the Indenture and subject
to certain limitations therein set forth, the transfer of this Security is registerable in the Security Register, upon surrender
of this Security for registration of transfer at the office or agency of the Company in any place where the principal of and any
premium and interest on this Security are payable, duly endorsed by, or accompanied by a written instrument of transfer in form
satisfactory to the Company and the Security Registrar duly executed by, the Holder hereof or his attorney duly authorized in writing,
and thereupon one or more new Securities of this series and of like tenor, of authorized denominations and for the same aggregate
principal amount, will be issued to the designated transferee or transferees.


 


The Securities of this series are issuable
only in registered form without coupons in denominations of $2,000 and any integral multiple of $1,000 in excess thereof. As provided
in the Indenture and subject to certain limitations therein set forth, Securities of this series are exchangeable for a like aggregate
principal amount of Securities of this series and of like tenor of a different authorized denomination, as requested by the Holder
surrendering the same.


 


No service charge shall be made for any
registration of transfer or exchange of the Notes, but the Company or the Security Registrar may require payment of a sum sufficient
to cover any transfer tax, assessments, or similar governmental charge payable in connection therewith (other than any such transfer
taxes, assessments or similar governmental charge payable upon exchange or transfer pursuant to Sections 9.6 or 11.7 of the Indenture).


 


Prior to due presentment of this Security
for registration of transfer, the Company, the Trustee and any agent of the Company or the Trustee will treat the Person in whose
name this Security is registered as the owner hereof for the purpose of receiving payments and for all other purposes, whether
or not this Security be overdue, and neither the Company, the Trustee nor any such agent shall be affected by notice to the contrary.


 


All terms used in this Security which are
defined in the Indenture and Supplemental Indenture shall have the meanings assigned to them in the Indenture and Supplemental
Indenture.


 


THIS SECURITY SHALL BE GOVERNED BY AND CONSTRUED
IN ACCORDANCE WITH THE LAWS OF THE STATE OF NEW YORK.


 






    A-2-15


     


    

 





 


This Security is a Book-Entry
Security within the meaning of the Indenture hereinafter referred to and is registered in the name of a Depository or a
nominee of a Depository. This Security is exchangeable for Securities registered in the name of a person other than the
Depository or its nominee only in the limited circumstances described in the Indenture and may not be transferred except as a
whole by the Depository to a nominee of the Depository or by a nominee of the Depository to the Depository or another nominee
of the Depository.


 


*                                        
*                                        
*


 




    A-2-16


     


    


 


SCHEDULE OF EXCHANGES


 


The following exchanges, redemptions or
purchases of a part of this Book-Entry Security have been made:


 


	Date of

Exchange/

Redemption/

Repurchase	

Amount of

decrease in

Principal Amount

of this Book-

Entry

Security	Amount of

increase in

Principal Amount

of this Book-

Entry Security	Principal Amount

of this Book-

Entry

Security following

such decrease (or

increase)	Signature of

authorized

signatory of

Trustee
	 	 	 	 	 
	 	 	 	 	 
	 	 	 	 	 





 




    A-2-17


     


    


 


ASSIGNMENT FORM


 


To assign this Security, fill in the form below:


 


I or we assign and transfer this Security to


 


(Print or type assignee’s
name, address and zip code)



 


 


(Insert assignee’s
soc. sec. or tax I.D. No.)


 



and irrevocably appoint                               
as agent to transfer this Security on the books of the Company. The agent may substitute another to act for him.


 


	Date:
	 
	Your Signature*:
	 
	By:
	 
	Name:
	 
	Title:




 


Sign exactly as your name appears on the
other side of this Security.


 


*Signature Guaranteed:


 


 


*NOTICE: The signature to this assignment must correspond with
the name as it appears upon the face of the within Note in every particular, without alteration, enlargement or any change whatever.
Such signature must be guaranteed by an “eligible guarantor institution” meeting the requirements of the Security Registrar,
which requirements include membership or participation in Security Transfer Agents Medallion Program (“STAMP”) or such
other “signature guarantee program” as may be determined by the Security Registrar in addition to, or in substitution
for, STAMP, all in accordance with the Securities Exchange Act of 1934, as amended.


 




    A-2-18


     


    


 


FORM
OF TRANSFER CERTIFICATE


 


In connection with any transfer of any of
the Securities evidenced by this certificate occurring prior to the expiration of the period referred to in Rule 144 under
the Securities Act (“Rule 144”) after the later of the date of original issuance of such Notes and the last date,
if any, on which such Notes were owned by the Company or any Affiliate (as such term is defined in Rule 144) of the Company,
the undersigned confirms that such Securities are being transferred in accordance with its terms:


 


CHECK
ONE BOX BELOW


 


	(1)	  ̈  to
the Company; or



 


	(2)	 ̈  pursuant
to an effective registration statement under the Securities Act; or



 


	(3)	 ̈  inside
the United States to a person reasonably believed to be a “qualified institutional buyer” (as defined in Rule 144A
under the Securities Act) that purchases for its own account or for the account of a qualified institutional buyer to whom notice
is given that such transfer is being made in reliance on Rule 144A, in each case pursuant to and in compliance with Rule 144A
under the Securities Act; or



 


	(4)	  ̈  in an offshore transaction in compliance with Rule 903 or Rule 904 of
                                                            Regulation S under the Securities Act; or



 


	(5)	 ̈  pursuant
to the exemption from registration provided by Rule 144 under the Securities Act or any other available exemption from the registration
requirement of the Securities Act.



 


Unless one of the boxes is checked,
the Trustee shall refuse to register any of the Securities evidenced by this certificate in the name of any person other than the
registered holder thereof; provided, however, that if box (5) is checked, the Trustee shall be entitled to require, prior
to registering any such transfer of the Securities, such legal opinions, certifications and other information as the Company has
reasonably requested to confirm that such transfer is being made pursuant to an exemption from, or in a transaction not subject
to, the registration requirements of the Securities Act.


 


____________________________________


Signature


 




    A-2-19


     


    


 


TO BE COMPLETED
BY PURCHASER IF (3) ABOVE IS CHECKED.


 


The undersigned represents and warrants that it is purchasing
this Security for its own account or an account with respect to which it exercises sole investment discretion and that it and any
such account is a “qualified institutional buyer” within the meaning of Rule 144A under the Securities Act, and is
aware that the sale to it is being made in reliance on Rule 144A and acknowledges that it has received such information regarding
the Company as the undersigned has requested pursuant to Rule 144A or has determined not to request such information and that it
is aware that the transferor is relying upon the undersigned’s foregoing representations in order to claim the exemption
from registration provided by Rule 144A.


 


	Dated:	 	 	Notice: To be executed by an executive officer



 




    A-2-20


     


    


 


FORM OF EXCHANGE CERTIFICATE


 


AbbVie Inc.


1 North Waukegan Road


North Chicago, Illinois 60064


 


U.S. Bank National Association


190 South LaSalle Street, 10th Floor


Chicago, IL 60603


Attention: Corporate Trust Services


 


Re: Senior Floating Rate Notes
due November 2021


 


Reference is hereby made to the Indenture,
dated as of November 8, 2012 (the “Base Indenture”), as supplemented by the First Supplemental Indenture, dated as
of November 8, 2012, the Second Supplemental Indenture, dated as of May 14, 2015, the Third Supplemental Indenture, dated as of
May 12, 2016, the Fourth Supplemental Indenture, dated as of November 17, 2016, the Fifth Supplemental Indenture, dated as of September
18, 2018, the Sixth Supplemental Indenture, dated as of September 26, 2019 and the Seventh Supplemental Indenture, dated as of
November 21, 2019 (as so supplemented, the “Indenture”), between AbbVie Inc. (the “Company”) and U.S. Bank
National Association, a national banking association as trustee. Capitalized terms used but not defined herein shall have the meanings
given to them in the Indenture.


 


___________ (the “Owner”) owns
and proposes to exchange the Security[ies] or interest in such Security[ies] specified herein, in the principal amount of $__________
in such Security[ies] or interests (the “Exchange”). In connection with the Exchange, the Owner hereby certifies that
in connection with the Exchange of the Owner’s Regulation S Global Note for a beneficial interest in the Rule 144A Global
Note, with an equal principal amount, the Security[ies] or interest in such Security[ies] specified herein [is][are] being transferred
to a Person (A) who the transferor reasonably believes to be a QIB, (B) purchasing for its own account or the account of a QIB
in a transaction meeting the requirements of Rule 144A, and (C) in accordance with all applicable securities laws of the States
of the United States and other jurisdictions.


 


This certificate and the statements contained
herein are made for your benefit and the benefit of the Company and are dated___________________.


 


	 	[Insert Name of Transferor]
	 	 
	 	By:	 
	 	 	Name:
	 	 	Title:
	 	 	 
	Dated:	 	 	 	 



 






    A-2-21


     


    

 






 


EXHIBIT A3


 


(FORM OF FACE OF INITIAL NOTE)


 


[THIS SECURITY IS A GLOBAL SECURITY WITHIN THE MEANING OF THE
INDENTURE HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME OF A DEPOSITARY OR A NOMINEE OF A DEPOSITARY. UNLESS AND UNTIL
IT IS EXCHANGED IN WHOLE OR IN PART FOR SECURITIES IN DEFINITIVE FORM IN ACCORDANCE WITH THE PROVISIONS OF THE INDENTURE AND THE
TERMS OF THE SECURITIES, TRANSFERS OF THIS GLOBAL SECURITY SHALL BE LIMITED TO TRANSFERS IN WHOLE, BUT NOT IN PART, TO THE DEPOSITORY
TRUST COMPANY, A NEW YORK CORPORATION (“DTC”), TO NOMINEES OF DTC OR TO A SUCCESSOR THEREOF OR SUCH SUCCESSOR’S
NOMINEE AND TRANSFERS OF PORTIONS OF THIS GLOBAL SECURITY SHALL BE LIMITED TO TRANSFERS MADE IN ACCORDANCE WITH THE RESTRICTIONS
SET FORTH IN THE INDENTURE REFERRED TO ON THE REVERSE HEREOF.


 


UNLESS THIS CERTIFICATE IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE
OF DTC, TO ABBVIE INC., OR ITS AGENT FOR REGISTRATION OF TRANSFER, EXCHANGE OR PAYMENT, AND ANY CERTIFICATE ISSUED IS REGISTERED
IN THE NAME OF CEDE & CO. OR IN SUCH OTHER NAME AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC (AND ANY PAYMENT IS
MADE TO CEDE & CO. OR TO SUCH OTHER ENTITY AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC), ANY TRANSFER, PLEDGE OR
OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL INASMUCH AS THE REGISTERED OWNER HEREOF, CEDE & CO.,
HAS AN INTEREST HEREIN.](1)


 


THIS SECURITY HAS NOT BEEN REGISTERED UNDER THE SECURITIES ACT
OF 1933, AS AMENDED (THE “SECURITIES ACT”), OR THE SECURITIES LAWS OF ANY STATE OR OTHER JURISDICTION.


 






    A-3-1


     


    

 


NEITHER THIS SECURITY NOR ANY INTEREST OR PARTICIPATION
HEREIN MAY BE REOFFERED, SOLD, ASSIGNED, TRANSFERRED, PLEDGED, ENCUMBERED OR OTHERWISE DISPOSED OF IN THE ABSENCE OF SUCH
REGISTRATION OR UNLESS SUCH TRANSACTION IS EXEMPT FROM, OR NOT SUBJECT TO, SUCH REGISTRATION. THE HOLDER OF THIS SECURITY, BY
ITS ACCEPTANCE HEREOF, AGREES ON ITS OWN BEHALF AND ON BEHALF OF ANY INVESTOR ACCOUNT FOR WHICH IT HAS PURCHASED SECURITIES,
TO OFFER, SELL OR OTHERWISE TRANSFER SUCH SECURITY, PRIOR TO THE DATE (THE “RESALE RESTRICTION TERMINATION DATE”)
THAT IS [IN THE CASE OF RULE 144A NOTES: ONE YEAR] [IN THE CASE OF REGULATION S NOTES: 40 DAYS] AFTER THE LATER OF THE ISSUE
DATE HEREOF OR ANY OTHER ISSUE DATE IN RESPECT OF A FURTHER ISSUANCE OF SECURITIES OF THE SAME SERIES AND THE LAST DATE ON
WHICH ABBVIE INC. OR ANY AFFILIATE OF ABBVIE INC. WAS THE OWNER OF THIS SECURITY (OR ANY PREDECESSOR OF SUCH SECURITY), ONLY
(A) TO ABBVIE INC. OR ANY SUBSIDIARY THEREOF, (B) PURSUANT TO A REGISTRATION STATEMENT THAT HAS BEEN DECLARED
EFFECTIVE UNDER THE SECURITIES ACT, (C) FOR SO LONG AS THE SECURITIES ARE ELIGIBLE FOR RESALE PURSUANT TO RULE 144A
UNDER THE SECURITIES ACT (“RULE 144A”), TO A PERSON IT REASONABLY BELIEVES IS A ‘‘QUALIFIED
INSTITUTIONAL BUYER’’ AS DEFINED IN RULE 144A THAT PURCHASES FOR ITS OWN ACCOUNT OR FOR THE ACCOUNT OF A
QUALIFIED INSTITUTIONAL BUYER TO WHOM NOTICE IS GIVEN THAT THE TRANSFER IS BEING MADE IN RELIANCE ON RULE 144A IN A
TRANSACTION MEETING THE REQUIREMENTS OF RULE 144A, (D) PURSUANT TO OFFERS AND SALES TO NON-U.S. PERSONS THAT OCCUR
OUTSIDE THE UNITED STATES WITHIN THE MEANING OF REGULATION S UNDER THE SECURITIES ACT, (E) TO AN INSTITUTIONAL
 “ACCREDITED INVESTOR” WITHIN THE MEANING OF RULE 501(a)(1), (2), (3) OR (7) UNDER THE SECURITIES ACT THAT IS
NOT A QUALIFIED INSTITUTIONAL BUYER AND THAT IS PURCHASING FOR ITS OWN ACCOUNT OR FOR THE ACCOUNT OF ANOTHER INSTITUTIONAL
ACCREDITED INVESTOR, IN EACH CASE IN A MINIMUM PRINCIPAL AMOUNT OF THE SECURITIES OF $250,000, FOR INVESTMENT PURPOSES AND
NOT WITH A VIEW TO OR FOR OFFER OR SALE IN CONNECTION WITH ANY DISTRIBUTION IN VIOLATION OF THE SECURITIES ACT
OR (F) PURSUANT TO ANOTHER AVAILABLE EXEMPTION FROM THE REGISTRATION REQUIREMENTS OF THE SECURITIES ACT, SUBJECT TO
ABBVIE INC.’S AND THE TRUSTEE’S RIGHT PRIOR TO ANY SUCH OFFER, SALE OR TRANSFER PURSUANT TO CLAUSES (D), (E)
OR (F) TO REQUIRE THE DELIVERY OF AN OPINION OF COUNSEL, CERTIFICATION AND/OR OTHER INFORMATION SATISFACTORY TO EACH OF
THEM.


 


[EACH PURCHASER OF THIS SECURITY IS HEREBY NOTIFIED THAT THE
SELLER OF THIS SECURITY MAY BE RELYING ON THE EXEMPTION FROM THE PROVISIONS OF SECTION 5 OF THE SECURITIES ACT PROVIDED BY
RULE 144A THEREUNDER.](2)


 


[BY ITS ACQUISITION HEREOF, THE HOLDER HEREOF REPRESENTS THAT
IT IS NOT A U.S. PERSON NOR IS IT PURCHASING FOR THE ACCOUNT OF A U.S. PERSON AND IS ACQUIRING THIS SECURITY IN AN OFFSHORE TRANSACTION
IN ACCORDANCE WITH REGULATION S UNDER THE SECURITIES ACT.](3)


 


[IN CONNECTION WITH ANY TRANSFER, THE
HOLDER WILL DELIVER TO THE REGISTRAR AND TRANSFER AGENT SUCH CERTIFICATES AND OTHER INFORMATION AS SUCH TRANSFER AGENT MAY REASONABLY
REQUIRE TO CONFIRM THAT THE TRANSFER COMPLIES WITH THE FOREGOING RESTRICTIONS.](4)


 





 



 (1) Applies to Global
Notes only


 


(2) Applies to Rule 144A Notes only


 


(3) Applies to Regulation S Notes only


 


(4) Applies to Notes in definitive form
only


 






    A-3-2


     


    

 


ABBVIE INC.


 


Senior Floating Rate Notes due 2022


 


	No. [●]	$[●]


 


CUSIP No: [●]


 


ISIN No: [●]


 


ABBVIE INC., a corporation duly organized
and existing under the laws of Delaware (herein called the “Company,” which term includes any successor Person
under the Indenture and Supplemental Indenture hereinafter referred to), for value received, hereby promises to pay to Cede &
Co., as nominee for The Depository Trust Company, or registered assigns, the principal sum of [●] Dollars ($[●]), or
such other principal sum as may be indicated on the Schedule of Exchanges attached hereto, on November 21, 2022 (the “Maturity
Date”), and to pay interest thereon from November 21, 2019 (the “Original Issue Date”) or from the
most recent Interest Payment Date (as defined below) to which interest has been paid or duly provided for, quarterly in arrears
on February 21, May 21, August 21 and November 21 of each year, commencing on February 21, 2020, subject to adjustment as provided
below (each, an “Interest Payment Date”), at a rate equal to the Benchmark (as defined on the reverse hereof),
which will initially be three-month LIBOR (as defined on the reverse hereof) plus 65 basis points and reset (as provided on the
reverse hereof) on each February 21, May 21, August 21 and November 21 (each, an “Interest Reset Date”) after
the Original Issue Date until the principal hereof is paid or made available for payment. Interest payments on this Security will
include interest accrued to but excluding the Interest Payment Date or Maturity Date, as the case may be. The interest so payable,
and punctually paid or duly provided for, on any Interest Payment Date will, as provided in such Indenture, be paid to the Person
in whose name this Security (or one or more Predecessor Securities) is registered at the close of business on the Regular Record
Date for such interest, which shall be the date that is 15 calendar days prior to the relevant Interest Payment Date (whether or
not such record date is a Business Day); provided, however, that interest payable at maturity of this Note shall be payable to
the persons to whom principal shall be payable, subject to DTC’s applicable procedures. Any such interest not so punctually
paid or duly provided for will forthwith cease to be payable to the Holder on such Regular Record Date and may either be paid to
the Person in whose name this Security (or one or more Predecessor Securities) is registered at the close of business on a Special
Record Date for the payment of such Defaulted Interest to be fixed by the Trustee, notice whereof shall be given to Holders of
Securities of this series not less than 10 days prior to such Special Record Date, or be paid at any time in any other lawful manner
not inconsistent with the requirements of any securities exchange on which the Securities of this series may be listed, and upon
such notice as may be required by such exchange, all as more fully provided in said Indenture.


 


If any Interest Reset Date for this
Security would otherwise be a day that is not a Business Day, such Interest Reset Date will be the next succeeding day that
is a Business Day, except that if the Business Day is in the next succeeding calendar month, the Interest Reset Date will be
the immediately preceding day that is a Business Day. “Business Day” means any calendar day that is not a
Saturday, Sunday or legal holiday in New York, New York and on which commercial banks are open for business in New York, New
York. If any Interest Payment Date (other than an interest payment date occurring on the Maturity Date) falls on a day that
is not a Business Day, such Interest Payment Date will be the following day that is a Business Day, except that, if the
Business Day is in the next succeeding calendar month, the Interest Payment Date shall be the immediately preceding day that
is a Business Day (in each case, resulting in a corresponding adjustment to the number of days in the applicable interest
period). If the Maturity Date falls on a day that is not a Business Day, the payment of principal and interest may be made on
the next succeeding Business Day, and no interest on that payment shall accrue for the period from and after such
maturity.


 






    A-3-3


     


    

 


Accrued interest is calculated by multiplying
the face amount by an accrued interest factor. The accrued interest factor is computed by adding the interest factor calculated
for each day from the Original Issue Date, or from, and including, the last Interest Payment Date, to, but excluding, the date
for which accrued interest is being calculated. The “interest factor” for each day is computed by dividing the interest
rate applicable to that day by 360. All percentages resulting from any calculation will be rounded, if necessary, to the nearest
one hundred-thousandth of a percentage point, with five one-millionths of a percentage point rounded upward (e.g., 9.876545% (or
..09876545) will be rounded upward to 9.87655% (or .0987655)), and all amounts used in or resulting from the calculation will be
rounded to the nearest cent (with one-half cent being rounded upward).


 


The calculation of the interest rate on
this Security will be made by U.S. Bank National Association, as “calculation agent.” If at any time the Trustee (as
defined on the reverse hereof) is not also the calculation agent, the Company will notify (or cause the calculation agent to notify)
the Trustee of each determination of the interest rate promptly after the determination is made by any successor calculation agent.
All calculations made by the calculation agent shall in the absence of manifest error be conclusive for all purposes and binding
on the Company, the Trustee and the Holder. Upon the request of the Holder, the Trustee will provide the interest rate then in
effect and, if determined, the interest rate that will become effective as a result of a determination made for the next Interest
Reset Date. The interest rate on this Security will in no event be higher than the maximum rate permitted by New York law, as the
same may be modified by United States law of general application.


 


Payment of the principal of (and
premium, if any) and any such interest on this Security will be made at the office or agency of the Company maintained for
that purpose in St. Paul, Minnesota, in such coin or currency of the United States of America as at the time of payment is
legal tender for payment of public and private debts; provided, however, that at the option of the Company payment of
interest may be made by (1) check mailed to the address of the Person entitled thereto as such address shall appear in
the Security Register or (2) wire transfer as directed by the Holder, in immediately available funds to an account
maintained by the Depository or its nominee with respect to a Global Note, and to the Holder or its nominee with respect to a
Definitive Note; provided further that in the case of a Definitive Note (1) the Holder thereof shall have provided
written wiring instructions to the Trustee on or before the related Regular Record Date and (2) if appropriate
instructions for any such wire transfer are not received by the related Regular Record Date, then such payment shall be made
by check mailed to the address of the Holder specified in the Security Register.


 






    A-3-4


     


    

 


Reference is hereby made to the further
provisions of this Security set forth on the reverse hereof, which further provisions shall for all purposes have the same effect
as if set forth at this place.


 


Unless the certificate of authentication
hereon has been executed by the Trustee referred to herein by manual signature, this Security shall not be entitled to any benefit
under the Indenture or be valid or obligatory for any purpose.


 






    A-3-5


     


    

 


IN WITNESS WHEREOF, the Company has caused
this instrument to be duly executed.


 


	Dated: November 21, 2019	
	 	 
	 	ABBVIE INC.
	 	 
	 	By:
	 	 	Name:
	 	 	Title:




 






    A-3-6


     


    

 


TRUSTEE’S CERTIFICATE OF AUTHENTICATION


 


This is one of the Securities of the series
designated therein referred to in the within-mentioned Indenture.


 


	Dated: November 21, 2019	 
	 
	 	U.S.
    BANK NATIONAL ASSOCIATION,

    as Trustee
	 	 
	 	By:
	 	 	Authorized Signatory



 






    A-3-7


     


    

 


[FORM OF REVERSE OF SECURITY]


 


This Security is one of a duly authorized
issue of securities of the Company (herein called the “Securities”), issued and to be issued in one or more
series under an Indenture, dated as of November 8, 2012, as it may be supplemented or amended from time to time (herein called
the “Indenture”), between the Company and U.S. Bank National Association, as Trustee (herein called the “Trustee,”
which term includes any successor trustee under the Indenture), and Supplemental Indenture No. 7, dated as of November 21,
2019 (herein called the “Supplemental Indenture”), between the Company and the Trustee, to which Indenture,
Supplemental Indenture and all indentures supplemental thereto reference is hereby made for a statement of the respective rights,
limitations of rights, duties and immunities thereunder of the Company, the Trustee and the Holders of the Securities of this series
and of the terms upon which the Securities of this series are, and are to be, authenticated and delivered. This Security is one
of the series designated on the face hereof, in an initial aggregate principal amount of $[●].


 


Interest


 


The interest rate in effect with respect
to the Securities of this series on each day that is not an Interest Reset Date will be the interest rate determined as of the
LIBOR Interest determination date (as defined below) pertaining to the immediately preceding Interest Reset Date and the interest
rate in effect on any day that is an Interest Reset Date will be the interest rate determined as of the LIBOR Interest determination
date pertaining to that Interest Reset Date, subject in either case to applicable provisions of law.


 


“LIBOR”
means the rate determined in accordance with the following provisions:


 


		(a)	With respect to a LIBOR Interest determination date, LIBOR will be the rate for deposits in
U.S. dollars having a maturity of three months, commencing on the first day of the applicable interest period immediately following
that LIBOR Interest determination date, that appears on the display on Reuters (or any successor service) on the LIBOR 01 page
(or any other page as may replace such page on such service or any such successor service, as the case may be) for the purpose
of displaying the London interbank rates of major banks for U.S. dollars (the “LIBOR Page”) as of 11:00 A.M., London
time, on that LIBOR Interest determination date.



 


		(b)	If the rate referred to in subparagraph (a) above does not appear on the LIBOR Page by 11:00
A.M., London time, on such LIBOR Interest determination date, LIBOR will be determined as follows:



 


(i)                 Except
as provided in clause (ii) below, the Company will select four major reference banks (which may include one or more of the
initial purchasers or their affiliates) in the London interbank market and will request the principal London office of each
of those four selected banks to provide the calculation agent with such bank’s quotation of the rate at which
three-month U.S. dollar deposits, commencing on the second London business day immediately following such LIBOR Interest
determination date, are offered to prime banks in the London interbank market at approximately 11:00 A.M., London time, on
such LIBOR Interest determination date and in a principal amount of not less than $1,000,000 that is representative for a
single transaction in such market at such time.


 






    A-3-8


     


    

 


A.            
If at least two such quotations are provided, then LIBOR for such LIBOR Interest determination date will be the arithmetic
mean of such quotations.


 


B.             
If fewer than two quotations are provided, then LIBOR for such LIBOR Interest determination date will be the arithmetic
mean of the rates quoted as of approximately 11:00 A.M. in the City of New York on such LIBOR Interest determination date by three
major banks (which may include one or more of the underwriters or their affiliates) in The City of New York selected by the Company
for three-month U.S. dollar loans, commencing on the second London business day immediately following such LIBOR Interest determination
date, and in a principal amount of not less than $1,000,000 that is representative for a single transaction in such market at such
time; provided, however, that if the banks selected as aforesaid by the Company are not quoting as mentioned in this sentence,
the rate of interest in effect for the applicable period will be the same as the interest rate in effect for the immediately preceding
interest period.


 


(ii)             
Notwithstanding clause (i) above, if the Company or the Designee (as defined below) determine on or prior to the relevant
LIBOR Interest determination date that a Benchmark Transition Event and its related Benchmark Replacement Date (each, as defined
below) have occurred with respect to LIBOR (or the then-current Benchmark, as applicable), then the provisions set forth below
under “Effect of Benchmark Transition Event,” which is referred to as the benchmark transition provisions, will thereafter
apply to all determinations of the rate of interest payable on the Securities. In accordance with the benchmark transition provisions,
after a Benchmark Transition Event and its related Benchmark Replacement Date have occurred, the amount of interest that will be
payable for each interest period will be an annual rate equal to the sum of the Benchmark Replacement (as defined herein) and the
margin specified herein. However, if the Company or the Designee determine that a Benchmark Transition Event and its related Benchmark
Replacement Date have occurred with respect to the then-current Benchmark, but for any reason the Benchmark Replacement has not
been determined as of the relevant LIBOR Interest determination date, the interest rate for the applicable interest period will
be equal to the interest rate for the immediately preceding interest period, as determined by the Company or the Designee.


 






    A-3-9


     


    

 


“LIBOR
Interest determination date” means the second London business day preceding each interest reset date.


 


Effect of Benchmark Transition Event


 


If the
Company (or its designee, which may be the calculation agent only if the calculation agent consents in writing to such appointment
in its sole discretion with no liability therefor, a successor calculation agent or such other designee of the Company (any of
such entities, the “Designee”)) determines that a Benchmark Transition Event and its related Benchmark Replacement
Date have occurred prior to the Reference Time in respect of any determination of the Benchmark on any date, the Benchmark Replacement
will replace the then-current Benchmark for all purposes relating to the Securities in respect of such determination on such date
and all determinations on all subsequent dates. If the Designee is not the calculation agent, the Company shall notify the Trustee
and the calculation agent in writing of the party that has been appointed by the Company as the Designee.


 


In connection
with the implementation of a Benchmark Replacement, the Company (or the Designee) will have the right to make Benchmark Replacement
Conforming Changes from time to time.


 


Any determination,
decision or election that may be made by the Company (or the Designee) pursuant to this Section titled “Effect of Benchmark
Transition Event,” including any determination with respect to tenor, rate or adjustment or of the occurrence or non-occurrence of
an event, circumstance or date and any decision to take or refrain from taking any action or any selection, will be conclusive
and binding absent manifest error, will be made in the Company’s (or the Designee’s) sole discretion, and, notwithstanding
anything to the contrary in the documentation relating to the Securities, shall become effective without consent from the holders
of the Securities or any other party. 


 


For purposes of the foregoing discussion
of the effect of Benchmark Transition Events, the following definitions are applicable:


 


“Benchmark”
means, initially, three-month LIBOR; provided that if a Benchmark Transition Event and its related Benchmark Replacement Date have
occurred with respect to three-month LIBOR or the then-current Benchmark, then “Benchmark” means the applicable Benchmark
Replacement.


 


“Benchmark
Replacement” means the Interpolated Benchmark with respect to the then-current Benchmark, plus the Benchmark
Replacement Adjustment for such Benchmark; provided that if the Company (or the Designee) cannot determine the Interpolated
Benchmark as of the Benchmark Replacement Date, then “Benchmark Replacement” means the first alternative set
forth in the order below that can be determined by the Company (or the Designee) as of the Benchmark Replacement Date: (1)
the sum of: (a) Term SOFR and (b) the Benchmark Replacement Adjustment; (2) the sum of: (a) Compounded SOFR and (b) the
Benchmark Replacement Adjustment; (3) the sum of: (a) the alternate rate of interest that has been selected or recommended by
the Relevant Governmental Body as the replacement for the then-current Benchmark for the applicable Corresponding Tenor and
(b) the Benchmark Replacement Adjustment; (4) the sum of: (a) the ISDA Fallback Rate
and (b) the Benchmark Replacement Adjustment; (5) the sum of: (a) the alternate rate of interest that has been selected by
the Company (or the Designee) as the replacement for the then-current Benchmark for the applicable Corresponding Tenor giving
due consideration to any industry-accepted rate of interest as a replacement for the then-current Benchmark for U.S. dollar
denominated Securities at such time and (b) the Benchmark Replacement Adjustment.


 






    A-3-10


     


    

 


“Benchmark Replacement Adjustment”
means the first alternative set forth in the order below that can be determined by the Company (or the Designee) as of the Benchmark
Replacement Date: (1) the spread adjustment, or method for calculating or determining such spread adjustment (which may be a positive
or negative value or zero), that has been selected or recommended by the Relevant Governmental Body for the applicable Unadjusted
Benchmark Replacement; (2) if the applicable Unadjusted Benchmark Replacement is equivalent to the ISDA Fallback Rate, then the
ISDA Fallback Adjustment; (3) the spread adjustment (which may be a positive or negative value or zero) that has been selected
by the Company (or the Designee) giving due consideration to any industry-accepted spread adjustment, or method for calculating
or determining such spread adjustment, for the replacement of the then-current Benchmark with the applicable Unadjusted Benchmark
Replacement for U.S. dollar denominated Securities at such time.


 


“Benchmark Replacement Conforming
Changes” means, with respect to any Benchmark Replacement, any technical, administrative or operational changes (including
changes to the definition of “interest period”, timing and frequency of determining rates and making payments of interest,
rounding of amounts or tenors, and other administrative matters) that the Company (or the Designee) decides may be appropriate
to reflect the adoption of such Benchmark Replacement in a manner substantially consistent with market practice (or, if the Company
(or the Designee) decides that adoption of any portion of such market practice is not administratively feasible or the Company
(or the Designee) determines that no market practice for use of the Benchmark Replacement exists, in such other manner as the Company
(or the Designee) determines is reasonably necessary).


 


“Benchmark Replacement Date”
means the earliest to occur of the following events with respect to the then-current Benchmark: (1) in the case of clause (1) or
(2) of the definition of “Benchmark Transition Event,” the later of (a) the date of the public statement or publication
of information referenced therein and (b) the date on which the administrator of the Benchmark permanently or indefinitely ceases
to provide the Benchmark; or (2) in the case of clause (3) of the definition of “Benchmark Transition Event,” the date
of the public statement or publication of information referenced therein. For the avoidance of doubt, if the event giving rise
to the Benchmark Replacement Date occurs on the same day as, but earlier than, the Reference Time in respect of any determination,
the Benchmark Replacement Date will be deemed to have occurred prior to the Reference Time for such determination.


 


“Benchmark Transition
Event” means the occurrence of one or more of the following events with respect to the then-current Benchmark: (1) a
public statement or publication of information by or on behalf of the administrator of the Benchmark announcing that such
administrator has ceased or will cease to provide the Benchmark, permanently or indefinitely, provided that, at the time of
such statement or publication, there is no successor administrator that will continue to provide the Benchmark; (2) a public
statement or publication of information by the regulatory supervisor for the administrator of the Benchmark, the central bank
for the currency of the Benchmark, an insolvency official with jurisdiction over the administrator for the Benchmark, a
resolution authority with jurisdiction over the administrator for the Benchmark or a court or an entity with similar
insolvency or resolution authority over the administrator for the Benchmark, which states that the administrator of the
Benchmark has ceased or will cease to provide the Benchmark permanently or indefinitely, provided that, at the time of such
statement or publication, there is no successor administrator that will continue to provide the Benchmark; or (3) a public
statement or publication of information by the regulatory supervisor for the administrator of the Benchmark announcing that
the Benchmark is no longer representative.


 






    A-3-11


     


    

 


“Compounded SOFR” means the
compounded average of SOFRs for the applicable Corresponding Tenor, with the rate, or methodology for this rate, and conventions
for this rate being established by the Company (or the Designee) in accordance with the rate, or methodology for this rate, and
conventions for this rate selected or recommended by the Relevant Governmental Body for determining compounded SOFR; provided that
if, and to the extent that, the Company (or the Designee) determines that Compounded SOFR cannot be determined in accordance with
clause (1) above, then the rate, or methodology for this rate, and conventions for this rate that have been selected by the Company
(or the Designee) giving due consideration to any industry-accepted market practice for U.S. dollar denominated Securities at such
time. For the avoidance of doubt, the calculation of Compounded SOFR shall exclude the Benchmark Replacement Adjustment and the
margin specified herein.


 


“Corresponding Tenor” with respect
to a Benchmark Replacement means a tenor (including overnight) having approximately the same length (disregarding business day
adjustment) as the applicable tenor for the then-current Benchmark.


 


“Federal Reserve Bank of New York’s
Website” means the website of the Federal Reserve Bank of New York at http://www.newyorkfed.org, or any successor source.


 


“Interpolated Benchmark” with
respect to the Benchmark means the rate determined for the Corresponding Tenor by interpolating on a linear basis between: (1)
the Benchmark for the longest period (for which the Benchmark is available) that is shorter than the Corresponding Tenor and (2)
the Benchmark for the shortest period (for which the Benchmark is available) that is longer than the Corresponding Tenor.


 


“ISDA Definitions” means the
2006 ISDA Definitions published by the International Swaps and Derivatives Association, Inc. or any successor thereto, as amended
or supplemented from time to time, or any successor definitional booklet for interest rate derivatives published from time to time.


 


“ISDA Fallback Adjustment” means
the spread adjustment (which may be a positive or negative value or zero) that would apply for derivatives transactions referencing
the ISDA Definitions to be determined upon the occurrence of an index cessation event with respect to the Benchmark for the applicable
tenor.


 






    A-3-12


     


    

 


“ISDA Fallback Rate” means the
rate that would apply for derivatives transactions referencing the ISDA Definitions to be effective upon the occurrence of an index
cessation date with respect to the Benchmark for the applicable tenor excluding the applicable ISDA Fallback Adjustment.


 


“Reference Time” with respect
to any determination of the Benchmark means (1) if the Benchmark is three-month LIBOR, 11:00 A.M. (London time) on the LIBOR Interest
determination date, and (2) if the Benchmark is not three-month LIBOR, the time determined by the Company (or the Designee) in
accordance with the Benchmark Replacement Conforming Changes.


 


“Relevant Governmental Body”
means the Federal Reserve Board and/or the Federal Reserve Bank of New York, or a committee officially endorsed or convened by
the Federal Reserve Board and/or the Federal Reserve Bank of New York or any successor thereto.


 


“SOFR” with respect to any day
means the secured overnight financing rate published for such day by the Federal Reserve Bank of New York, as the administrator
of the benchmark (or a successor administrator), on the Federal Reserve Bank of New York’s Website.


 


“Term SOFR” means the forward-looking
term rate for the applicable Corresponding Tenor based on SOFR that has been selected or recommended by the Relevant Governmental
Body.


 


“Unadjusted Benchmark Replacement”
means the Benchmark Replacement excluding the Benchmark Replacement Adjustment.


 


Optional Redemption 


 


The Securities of this series may not be
redeemed prior to maturity.


 


Special Mandatory Redemption 


 


If (i)
the consummation of the Acquisition (as defined below) does not occur on or before January 30, 2021 or (ii) the Company notifies
the Trustee that the Company will not pursue the consummation of the Acquisition (each of (i) and (ii), a “Special Mandatory
Redemption Trigger”), the Company will be required to redeem the Securities of this series then outstanding (such redemption,
the “Special Mandatory Redemption”) at a redemption price equal to 101% of the principal amount of such Securities
plus accrued and unpaid interest, if any, to, but not including, the Special Mandatory Redemption Date (the “Special Mandatory
Redemption Price”). The “Acquisition” means the acquisition by the Company of Allergan plc and its
subsidiaries pursuant to the definitive transaction agreement, dated as of June 25, 2019, by and among the Company, Venice Subsidiary
LLC, a Delaware limited liability company and a direct wholly owned subsidiary of the Company, and Allergan plc, as amended from
time to time.


 


In
the event that the Company becomes obligated to redeem the Securities of this series pursuant to the Special Mandatory
Redemption, the Company will promptly, and in any event not more than five Business Days after the date on which a Special
Mandatory Redemption Trigger occurred, deliver notice to the Trustee of the Special Mandatory Redemption and the date
upon which the Securities of this series will be redeemed (the “Special Mandatory Redemption Date,” which
date shall be no later than the third Business Day following the date of such notice) together with a notice of Special
Mandatory Redemption for the Trustee to deliver to each registered holder of the Securities of this series to be redeemed.
The Trustee will then promptly mail, or electronically deliver, according to the procedures of DTC, such notice of Special
Mandatory Redemption to each registered holder of the Securities of this series to be redeemed. Unless the Company defaults
in payment of the Special Mandatory Redemption Price, on and after such Special Mandatory Redemption Date, interest will
cease to accrue on the Securities of this series to be redeemed.


 






    A-3-13


     


    

 


Failure to comply in any material respect
with any obligations in the provisions described under this caption “Special Mandatory Redemption” shall constitute
an “Event of Default” under Section 5.1(7) of the Indenture.


 


Notwithstanding the foregoing, installments
of interest on the Securities of this series that are due and payable on Interest Payment Dates falling on or prior to the Special
Mandatory Redemption Date will be payable on such Interest Payment Dates to the Holder as of the close of business on the relevant
Record Dates in accordance with the Securities of this series and the Indenture.


 


For the avoidance of doubt, Article Eleven
of the Indenture shall not apply to the Special Mandatory Redemption.


 


Sinking Fund 


 


The Securities of this series do not provide
for a sinking fund.


 


Default


 


If an Event of Default with respect to Securities
of this series shall occur and be continuing, the principal of the Securities of this series may be declared due and payable in
the manner and with the effect provided in the Indenture.


 


Miscellaneous 


 


The Indenture contains provisions for defeasance
at any time of the entire indebtedness of this Security or certain restrictive covenants and Events of Default with respect to
this Security, in each case upon compliance with certain conditions set forth therein. Sections 13.2 and 13.3 of the Indenture
apply to the Securities of this series.


 


The Indenture permits, with certain
exceptions as therein provided, the amendment thereof and the modification of the rights and obligations of the Company and
the rights of the Holders of the Securities of each series to be affected under the Indenture at any time by the Company and
the Trustee with the consent of the Holders of not less than a majority in principal amount of the Securities at the time
Outstanding of each series to be affected. The Indenture also contains provisions permitting the Holders of specified
percentages in principal amount of the Securities at the time Outstanding of any series, on behalf of the Holders of all
Securities of such series, to waive compliance by the Company with certain provisions of the Indenture and certain past
defaults under the Indenture and their consequences. Any such consent or waiver by the Holder of this Security shall be
conclusive and binding upon such Holder and upon all future Holders of this Security and of any Security issued upon the
registration of transfer hereof or in exchange herefor or in lieu hereof, whether or not notation of such consent or waiver
is made upon this Security.


 






    A-3-14


     


    

 


No reference herein to the Indenture or
Supplemental Indenture and no provision of this Security or of the Indenture or Supplemental Indenture shall alter or impair the
obligation of the Company, which is absolute and unconditional, to pay the principal of and any premium and interest on this Security
at the times, place and rate, and in the coin or currency, herein prescribed.


 


As provided in the Indenture and subject
to certain limitations therein set forth, the transfer of this Security is registerable in the Security Register, upon surrender
of this Security for registration of transfer at the office or agency of the Company in any place where the principal of and any
premium and interest on this Security are payable, duly endorsed by, or accompanied by a written instrument of transfer in form
satisfactory to the Company and the Security Registrar duly executed by, the Holder hereof or his attorney duly authorized in writing,
and thereupon one or more new Securities of this series and of like tenor, of authorized denominations and for the same aggregate
principal amount, will be issued to the designated transferee or transferees.


 


The Securities of this series are issuable
only in registered form without coupons in denominations of $2,000 and any integral multiple of $1,000 in excess thereof. As provided
in the Indenture and subject to certain limitations therein set forth, Securities of this series are exchangeable for a like aggregate
principal amount of Securities of this series and of like tenor of a different authorized denomination, as requested by the Holder
surrendering the same.


 


No service charge shall be made for any
registration of transfer or exchange of the Notes, but the Company or the Security Registrar may require payment of a sum sufficient
to cover any transfer tax, assessments, or similar governmental charge payable in connection therewith (other than any such transfer
taxes, assessments or similar governmental charge payable upon exchange or transfer pursuant to Sections 9.6 or 11.7 of the Indenture).


 


Prior to due presentment of this Security
for registration of transfer, the Company, the Trustee and any agent of the Company or the Trustee will treat the Person in whose
name this Security is registered as the owner hereof for the purpose of receiving payments and for all other purposes, whether
or not this Security be overdue, and neither the Company, the Trustee nor any such agent shall be affected by notice to the contrary.


 


All terms used in this Security which are
defined in the Indenture and Supplemental Indenture shall have the meanings assigned to them in the Indenture and Supplemental
Indenture.


 


THIS SECURITY SHALL BE GOVERNED BY AND CONSTRUED
IN ACCORDANCE WITH THE LAWS OF THE STATE OF NEW YORK.


 


This Security is a Book-Entry
Security within the meaning of the Indenture hereinafter referred to and is registered in the name of a Depository or a
nominee of a Depository. This Security is exchangeable for Securities registered in the name of a person other than the
Depository or its nominee only in the limited circumstances described in the Indenture and may not be transferred except as a
whole by the Depository to a nominee of the Depository or by a nominee of the Depository to the Depository or another nominee
of the Depository.


 


*                                        
*                                        
*


 






    A-3-15


     


    

 


SCHEDULE OF EXCHANGES


 


The following exchanges, redemptions or
purchases of a part of this Book-Entry Security have been made:


 


	Date of

Exchange/

Redemption/

Repurchase	Amount of

decrease in

Principal Amount

of this Book-

Entry

Security	Amount of

increase in

Principal Amount

of this Book-

Entry Security	Principal Amount

of this Book-

Entry

Security following

such decrease (or

increase)	Signature of

authorized

signatory of

Trustee
	 	 	 	 	 
	 	 	 	 	 
	 	 	 	 	 


 






    A-3-16


     


    

 


ASSIGNMENT FORM


 


To assign this Security, fill in the form below:


 


I or we assign and transfer this Security to


 


 


	(Print or type assignee’s name, address and zip code)


 


 


	(Insert assignee’s soc. sec. or tax I.D. No.)


 


and irrevocably appoint                               
as agent to transfer this Security on the books of the Company. The agent may substitute another to act for him.


 


 


Date:


 


Your Signature*:


 


By:


 


Name:


 


Title:


 


 


Sign exactly as your name appears on the
other side of this Security.


 


 


 


*Signature Guaranteed:


 


 


*NOTICE: The signature to this assignment must correspond with
the name as it appears upon the face of the within Note in every particular, without alteration, enlargement or any change whatever.
Such signature must be guaranteed by an “eligible guarantor institution” meeting the requirements of the Security Registrar,
which requirements include membership or participation in Security Transfer Agents Medallion Program (“STAMP”) or such
other “signature guarantee program” as may be determined by the Security Registrar in addition to, or in substitution
for, STAMP, all in accordance with the Securities Exchange Act of 1934, as amended.


 






    A-3-17


     


    

 


FORM
OF TRANSFER CERTIFICATE


 


In connection with any transfer of any of
the Securities evidenced by this certificate occurring prior to the expiration of the period referred to in Rule 144 under
the Securities Act (“Rule 144”) after the later of the date of original issuance of such Notes and the last date,
if any, on which such Notes were owned by the Company or any Affiliate (as such term is defined in Rule 144) of the Company,
the undersigned confirms that such Securities are being transferred in accordance with its terms:


 


CHECK
ONE BOX BELOW


 


		(1)	 ̈ to the Company; or





 


		(2)	 ̈ pursuant to an effective registration statement under the Securities
                                                              Act; or



 


		(3)	 ̈ inside the United States to a person reasonably believed to be a
                                                              “qualified institutional buyer” (as defined in Rule 144A under the Securities Act) that purchases for its own
                                                              account or for the account of a qualified institutional buyer to whom notice is given that such transfer is being made in
                                                              reliance on Rule 144A, in each case pursuant to and in compliance with Rule 144A under the Securities Act; or



 


		(4)	 ̈ in an offshore transaction in compliance with Rule 903 or Rule 904 of
                                                              Regulation S under the Securities Act; or



 


		(5)	 ̈ pursuant to the exemption from registration provided by Rule 144 under
                                                              the Securities Act or any other available exemption from the registration requirement of the Securities Act.



 


Unless one of the boxes is checked,
the Trustee shall refuse to register any of the Securities evidenced by this certificate in the name of any person other than the
registered holder thereof; provided, however, that if box (5) is checked, the Trustee shall be entitled to require, prior
to registering any such transfer of the Securities, such legal opinions, certifications and other information as the Company has
reasonably requested to confirm that such transfer is being made pursuant to an exemption from, or in a transaction not subject
to, the registration requirements of the Securities Act.


 


	 	Signature



 






    A-3-18


     


    

 


TO BE COMPLETED
BY PURCHASER IF (3) ABOVE IS CHECKED.


 


The undersigned represents and warrants that it is purchasing
this Security for its own account or an account with respect to which it exercises sole investment discretion and that it and any
such account is a “qualified institutional buyer” within the meaning of Rule 144A under the Securities Act, and is
aware that the sale to it is being made in reliance on Rule 144A and acknowledges that it has received such information regarding
the Company as the undersigned has requested pursuant to Rule 144A or has determined not to request such information and that it
is aware that the transferor is relying upon the undersigned’s foregoing representations in order to claim the exemption
from registration provided by Rule 144A.


 


	Dated:____________________	Notice: To be executed by an executive officer



 






    A-3-19


     


    

 


FORM OF EXCHANGE CERTIFICATE


 


AbbVie Inc.


1 North Waukegan Road


North Chicago, Illinois 60064


 


U.S. Bank National Association


190 South LaSalle Street, 10th Floor


Chicago, IL 60603


Attention: Corporate Trust Services


 


Re: Senior Floating Rate Notes
due 2022


 


Reference is hereby made to the Indenture,
dated as of November 8, 2012 (the “Base Indenture”), as supplemented by the First Supplemental Indenture, dated as
of November 8, 2012, the Second Supplemental Indenture, dated as of May 14, 2015, the Third Supplemental Indenture, dated as of
May 12, 2016, the Fourth Supplemental Indenture, dated as of November 17, 2016, the Fifth Supplemental Indenture, dated as of September
18, 2018, the Sixth Supplemental Indenture, dated as of September 26, 2019 and the Seventh Supplemental Indenture, dated as of
November 21, 2019 (as so supplemented, the “Indenture”), between AbbVie Inc. (the “Company”) and U.S. Bank
National Association, a national banking association as trustee. Capitalized terms used but not defined herein shall have the meanings
given to them in the Indenture.


 


___________ (the “Owner”) owns
and proposes to exchange the Security[ies] or interest in such Security[ies] specified herein, in the principal amount of $__________
in such Security[ies] or interests (the “Exchange”). In connection with the Exchange, the Owner hereby certifies that
in connection with the Exchange of the Owner’s Regulation S Global Note for a beneficial interest in the Rule 144A Global
Note, with an equal principal amount, the Security[ies] or interest in such Security[ies] specified herein [is][are] being transferred
to a Person (A) who the transferor reasonably believes to be a QIB, (B) purchasing for its own account or the account of a QIB
in a transaction meeting the requirements of Rule 144A, and (C) in accordance with all applicable securities laws of the States
of the United States and other jurisdictions.


 


This certificate and the statements contained
herein are made for your benefit and the benefit of the Company and are dated ______________________.


 


	 	[Insert Name of Transferor]
	 	 
	 	By:	 
	 	 	Name:
	 	 	Title:
	 	 
	Dated: _________________________________	




 






    A-3-20


     


    

 



 


EXHIBIT A4


 


(FORM OF FACE OF INITIAL NOTE)


 


[THIS SECURITY IS A GLOBAL SECURITY WITHIN THE MEANING OF THE
INDENTURE HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME OF A DEPOSITARY OR A NOMINEE OF A DEPOSITARY. UNLESS AND UNTIL
IT IS EXCHANGED IN WHOLE OR IN PART FOR SECURITIES IN DEFINITIVE FORM IN ACCORDANCE WITH THE PROVISIONS OF THE INDENTURE AND THE
TERMS OF THE SECURITIES, TRANSFERS OF THIS GLOBAL SECURITY SHALL BE LIMITED TO TRANSFERS IN WHOLE, BUT NOT IN PART, TO THE DEPOSITORY
TRUST COMPANY, A NEW YORK CORPORATION (“DTC”), TO NOMINEES OF DTC OR TO A SUCCESSOR THEREOF OR SUCH SUCCESSOR’S
NOMINEE AND TRANSFERS OF PORTIONS OF THIS GLOBAL SECURITY SHALL BE LIMITED TO TRANSFERS MADE IN ACCORDANCE WITH THE RESTRICTIONS
SET FORTH IN THE INDENTURE REFERRED TO ON THE REVERSE HEREOF.


 


UNLESS THIS CERTIFICATE IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE
OF DTC, TO ABBVIE INC., OR ITS AGENT FOR REGISTRATION OF TRANSFER, EXCHANGE OR PAYMENT, AND ANY CERTIFICATE ISSUED IS REGISTERED
IN THE NAME OF CEDE & CO. OR IN SUCH OTHER NAME AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC (AND ANY PAYMENT IS
MADE TO CEDE & CO. OR TO SUCH OTHER ENTITY AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC), ANY TRANSFER, PLEDGE OR
OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL INASMUCH AS THE REGISTERED OWNER HEREOF, CEDE & CO.,
HAS AN INTEREST HEREIN.](1)


 


THIS SECURITY HAS NOT BEEN REGISTERED UNDER THE SECURITIES ACT
OF 1933, AS AMENDED (THE “SECURITIES ACT”), OR THE SECURITIES LAWS OF ANY STATE OR OTHER JURISDICTION.


 






    A-4-1


     


    

 


NEITHER THIS SECURITY NOR ANY INTEREST OR PARTICIPATION HEREIN
MAY BE REOFFERED, SOLD, ASSIGNED, TRANSFERRED, PLEDGED, ENCUMBERED OR OTHERWISE DISPOSED OF IN THE ABSENCE OF SUCH REGISTRATION
OR UNLESS SUCH TRANSACTION IS EXEMPT FROM, OR NOT SUBJECT TO, SUCH REGISTRATION. THE HOLDER OF THIS SECURITY, BY ITS ACCEPTANCE
HEREOF, AGREES ON ITS OWN BEHALF AND ON BEHALF OF ANY INVESTOR ACCOUNT FOR WHICH IT HAS PURCHASED SECURITIES, TO OFFER, SELL OR
OTHERWISE TRANSFER SUCH SECURITY, PRIOR TO THE DATE (THE “RESALE RESTRICTION TERMINATION DATE”) THAT IS [IN THE CASE
OF RULE 144A NOTES: ONE YEAR] [IN THE CASE OF REGULATION S NOTES: 40 DAYS] AFTER THE LATER OF THE ISSUE DATE HEREOF OR ANY OTHER
ISSUE DATE IN RESPECT OF A FURTHER ISSUANCE OF SECURITIES OF THE SAME SERIES AND THE LAST DATE ON WHICH ABBVIE INC. OR ANY AFFILIATE
OF ABBVIE INC. WAS THE OWNER OF THIS SECURITY (OR ANY PREDECESSOR OF SUCH SECURITY), ONLY (A) TO ABBVIE INC. OR ANY SUBSIDIARY
THEREOF, (B) PURSUANT TO A REGISTRATION STATEMENT THAT HAS BEEN DECLARED EFFECTIVE UNDER THE SECURITIES ACT, (C) FOR
SO LONG AS THE SECURITIES ARE ELIGIBLE FOR RESALE PURSUANT TO RULE 144A UNDER THE SECURITIES ACT (“RULE 144A”),
TO A PERSON IT REASONABLY BELIEVES IS A ‘‘QUALIFIED INSTITUTIONAL BUYER’’ AS DEFINED IN RULE 144A
THAT PURCHASES FOR ITS OWN ACCOUNT OR FOR THE ACCOUNT OF A QUALIFIED INSTITUTIONAL BUYER TO WHOM NOTICE IS GIVEN THAT THE TRANSFER
IS BEING MADE IN RELIANCE ON RULE 144A IN A TRANSACTION MEETING THE REQUIREMENTS OF RULE 144A, (D) PURSUANT TO OFFERS
AND SALES TO NON-U.S. PERSONS THAT OCCUR OUTSIDE THE UNITED STATES WITHIN THE MEANING OF REGULATION S UNDER THE SECURITIES
ACT, (E) TO AN INSTITUTIONAL “ACCREDITED INVESTOR” WITHIN THE MEANING OF RULE 501(a)(1), (2), (3) OR (7)
UNDER THE SECURITIES ACT THAT IS NOT A QUALIFIED INSTITUTIONAL BUYER AND THAT IS PURCHASING FOR ITS OWN ACCOUNT OR FOR THE ACCOUNT
OF ANOTHER INSTITUTIONAL ACCREDITED INVESTOR, IN EACH CASE IN A MINIMUM PRINCIPAL AMOUNT OF THE SECURITIES OF $250,000, FOR INVESTMENT
PURPOSES AND NOT WITH A VIEW TO OR FOR OFFER OR SALE IN CONNECTION WITH ANY DISTRIBUTION IN VIOLATION OF THE SECURITIES ACT OR
(F) PURSUANT TO ANOTHER AVAILABLE EXEMPTION FROM THE REGISTRATION REQUIREMENTS OF THE SECURITIES ACT, SUBJECT TO ABBVIE INC.’S
AND THE TRUSTEE’S RIGHT PRIOR TO ANY SUCH OFFER, SALE OR TRANSFER PURSUANT TO CLAUSES (D), (E) OR (F) TO REQUIRE THE
DELIVERY OF AN OPINION OF COUNSEL, CERTIFICATION AND/OR OTHER INFORMATION SATISFACTORY TO EACH OF THEM.


 


[EACH PURCHASER OF THIS SECURITY IS HEREBY NOTIFIED THAT THE
SELLER OF THIS SECURITY MAY BE RELYING ON THE EXEMPTION FROM THE PROVISIONS OF SECTION 5 OF THE SECURITIES ACT PROVIDED BY
RULE 144A THEREUNDER.](2)


 


[BY ITS ACQUISITION HEREOF, THE HOLDER HEREOF REPRESENTS THAT
IT IS NOT A U.S. PERSON NOR IS IT PURCHASING FOR THE ACCOUNT OF A U.S. PERSON AND IS ACQUIRING THIS SECURITY IN AN OFFSHORE TRANSACTION
IN ACCORDANCE WITH REGULATION S UNDER THE SECURITIES ACT.](3)


 


[IN CONNECTION WITH ANY TRANSFER, THE HOLDER WILL DELIVER TO
THE REGISTRAR AND TRANSFER AGENT SUCH CERTIFICATES AND OTHER INFORMATION AS SUCH TRANSFER AGENT MAY REASONABLY REQUIRE TO CONFIRM
THAT THE TRANSFER COMPLIES WITH THE FOREGOING RESTRICTIONS.](4)


 


(1) Applies to Global Notes only


 


(2) Applies to Rule 144A Notes only


 


(3) Applies to Regulation S Notes only


 


(4) Applies to Notes in definitive form
only


 






    A-4-2


     


    

 


ABBVIE INC.


 


2.150% Senior Notes due 2021


 


	No. [●]	$[●]


 


CUSIP No: [●]


 


ISIN No: [●]


 


ABBVIE INC., a corporation duly organized
and existing under the laws of Delaware (herein called the “Company,” which term includes any successor Person
under the Indenture and Supplemental Indenture hereinafter referred to), for value received, hereby promises to pay to Cede &
Co., as nominee for The Depository Trust Company, or registered assigns, the principal sum of [●] Dollars ($[●]), or
such other principal sum as may be indicated on the Schedule of Exchanges attached hereto, on November 19, 2021, and to pay interest
thereon from November 21, 2019 or from the most recent Interest Payment Date to which interest has been paid or duly provided for,
semi-annually in arrears on May 19 and November 19 of each year, commencing on May 19, 2020, at the rate of 2.150% per annum, until
the principal hereof is paid or made available for payment. The interest so payable, and punctually paid or duly provided for,
on any Interest Payment Date will, as provided in such Indenture, be paid to the Person in whose name this Security (or one or
more Predecessor Securities) is registered at the close of business on the Regular Record Date for such interest, which shall be
the date that is 15 calendar days prior to the relevant Interest Payment Date (whether or not a Business Day). Any such interest
not so punctually paid or duly provided for will forthwith cease to be payable to the Holder on such Regular Record Date and may
either be paid to the Person in whose name this Security (or one or more Predecessor Securities) is registered at the close of
business on a Special Record Date for the payment of such Defaulted Interest to be fixed by the Trustee, notice whereof shall be
given to Holders of Securities of this series not less than 10 days prior to such Special Record Date, or be paid at any time in
any other lawful manner not inconsistent with the requirements of any securities exchange on which the Securities of this series
may be listed, and upon such notice as may be required by such exchange, all as more fully provided in said Indenture.


 


Payment of the principal of (and premium,
if any) and any such interest on this Security will be made at the office or agency of the Company maintained for that purpose
in St. Paul, Minnesota, in such coin or currency of the United States of America as at the time of payment is legal tender for
payment of public and private debts; provided, however, that at the option of the Company payment of interest may be made by (1) check
mailed to the address of the Person entitled thereto as such address shall appear in the Security Register or (2) wire transfer
as directed by the Holder, in immediately available funds to an account maintained by the Depository or its nominee with respect
to a Global Note, and to the Holder or its nominee with respect to a Definitive Note; provided further that in the case of a Definitive
Note (1) the Holder thereof shall have provided written wiring instructions to the Trustee on or before the related Regular
Record Date and (2) if appropriate instructions for any such wire transfer are not received by the related Regular Record
Date, then such payment shall be made by check mailed to the address of the Holder specified in the Security Register.


 






    A-4-3


     


    

 


Reference is hereby made to the further
provisions of this Security set forth on the reverse hereof, which further provisions shall for all purposes have the same effect
as if set forth at this place.


 


Unless the certificate of authentication
hereon has been executed by the Trustee referred to herein by manual signature, this Security shall not be entitled to any benefit
under the Indenture or be valid or obligatory for any purpose.


 






    A-4-4


     


    

 


IN WITNESS WHEREOF, the Company has caused
this instrument to be duly executed.


 


Dated: November 21, 2019


 


 


	 	ABBVIE INC.
	 	 
	 	By: 
	 	 	Name: 
	 	 	Title: 




 






    A-4-5


     


    

 


TRUSTEE’S CERTIFICATE OF AUTHENTICATION


 


This is one of the Securities of the series
designated therein referred to in the within-mentioned Indenture.


 


Dated: November 21, 2019


 


 


	 

                                                                                
	U.S. BANK NATIONAL ASSOCIATION,
	 	 	as Trustee
	 	 	 
	 	By:
	 	 	Authorized Signatory




 






    A-4-6


     


    

 


[FORM OF REVERSE OF SECURITY]


 


This Security is one of a duly authorized
issue of securities of the Company (herein called the “Securities”), issued and to be issued in one or more
series under an Indenture, dated as of November 8, 2012, as it may be supplemented or amended from time to time (herein called
the “Indenture”), between the Company and U.S. Bank National Association, as Trustee (herein called the “Trustee,”
which term includes any successor trustee under the Indenture), and Supplemental Indenture No. 7, dated as of November 21,
2019 (herein called the “Supplemental Indenture”), between the Company and the Trustee, to which Indenture,
Supplemental Indenture and all indentures supplemental thereto reference is hereby made for a statement of the respective rights,
limitations of rights, duties and immunities thereunder of the Company, the Trustee and the Holders of the Securities of this series
and of the terms upon which the Securities of this series are, and are to be, authenticated and delivered. This Security is one
of the series designated on the face hereof, in an initial aggregate principal amount of $[●].


 


Optional Redemption


 


At any time prior to the Maturity Date (as
defined below), the Company may redeem some or all of the Securities of this series at its option, in each case at a redemption
price equal to the greater of (i) 100% of the principal amount of the Securities of this series to be redeemed; and (ii) the sum
of the present values of the remaining scheduled payments through the Maturity Date of principal and interest on the Securities
of this series to be redeemed (exclusive of interest accrued to the Redemption Date) discounted to the Redemption Date on a semiannual
basis (assuming a 360-day year consisting of twelve 30-day months) at the then current Treasury Rate, plus 10 basis points.


 


The Company will pay accrued and unpaid
interest on the principal amount of the Securities of this series being redeemed to, but excluding, the Redemption Date.


 


If the Company has given notice as provided
in the Indenture and funds for the redemption of any Securities of this series called for redemption have been made available on
the Redemption Date in accordance with the Indenture, such Securities will cease to bear interest on the date fixed for redemption.
Thereafter, the only right of the Holders of such Securities will be to receive payment of the redemption price.


 


The Company will give notice of any optional
redemption, electronically or by mail, to Holders at their addresses, as shown in the Security Register for such Securities, or
as otherwise in accordance with the applicable procedures of DTC, not more than 60 nor less than 15 days prior to the date fixed
for redemption. The notice of redemption will specify, among other items, the Redemption Date, redemption price, the principal
amount of the Securities of this series to be redeemed and the place or places that payment will be made upon surrender of the
Securities of this series to be redeemed. Any redemption or notice of redemption may, at the Company’s discretion, be subject
to one or more conditions precedent, and, at the Company’s discretion, the redemption date may be delayed until such time
as any or all such conditions shall be satisfied. The Company shall provide written notice to the Trustee prior to the close of
business two Business Days prior to the redemption date if any such redemption has been rescinded or delayed, and upon receipt
the Trustee shall provide such notice to each holder of the Securities in the same manner in which the notice of redemption was
given.


 






    A-4-7


     


    

 


The Company will notify the Trustee at least
30 days prior to the Redemption Date fixed by the Company (or such shorter period as is satisfactory to the Trustee) of the aggregate
principal amount of the Securities of this series to be redeemed and their Redemption Date. If less than all of the Securities
of this series are to be redeemed at any time, the Trustee shall select, not more than 30 days prior to the Redemption Date, which
Securities or the portion thereof, that are to be redeemed from the outstanding Securities of this series not previously redeemed
by random lot.


 


“Comparable Treasury Issue”
means the United States Treasury security selected by the Independent Investment Banker as having a maturity comparable to the
remaining term (“Remaining Life”) of the Securities of this series to be redeemed that would be utilized, at the time
of selection and in accordance with customary financial practice, in pricing new issues of corporate debt securities of comparable
maturity to the Remaining Life of such Securities.


 


“Comparable Treasury Price”
means, with respect to any Redemption Date, (1) if the Company obtains four or more Reference Treasury Dealer Quotations for
such Redemption Date, the average of such Reference Treasury Dealer Quotations, after excluding the highest and lowest Reference
Treasury Dealer Quotations, or (2) if the Company obtains fewer than four such Reference Treasury Dealer Quotations, the average
of all such quotations.


 


“Independent Investment Banker”
means one of the Reference Treasury Dealers that the Company appoints to act as the Independent Investment Banker from time to
time.


 


“Business Day” means
any calendar day that is not a Saturday, Sunday or legal holiday in New York, New York and on which commercial banks are open for
business in New York, New York.


 


“Maturity Date” means
November 19, 2021.


 


“Primary Treasury Dealer”
means a primary United States government securities dealer in the United States of America.


 


“Reference Treasury Dealer”
means (i) each of Morgan Stanley & Co. LLC, BofA Securities, Inc., Barclays Capital Inc. and any of their respective successors;
provided, however, that if any of them ceases to be a Primary Treasury Dealer, the Company will substitute therefor another Primary
Treasury Dealer and (ii) any other Primary Treasury Dealers the Company selects.


 


“Reference Treasury Dealer Quotations”
means, with respect to each Reference Treasury Dealer and any Redemption Date, the average, as determined by the Company, of the
bid and asked prices for the Comparable Treasury Issue (expressed in each case as a percentage of its principal amount) quoted
in writing to the Company by such Reference Treasury Dealer at 3:30 p.m., New York City time, on the third Business Day preceding
such Redemption Date.


 






    A-4-8


     


    

 


“Treasury Rate” means,
with respect to any Redemption Date, (1) the rate per annum equal to the yield, under the heading which represents the average
for the immediately preceding week, appearing in the most recently published statistical release designated “H.15(519)”
or any successor publication which is published weekly by the Board of Governors of the Federal Reserve System and which establishes
yields on actively traded United States Treasury securities adjusted to constant maturity under the caption “Treasury Constant
Maturities” for the maturity corresponding to the Comparable Treasury Issue; provided that, if no maturity is within three
months before or after the Remaining Life of the Securities of this series to be redeemed, yields for the two published maturities
most closely corresponding to the Comparable Treasury Issue shall be determined and the Treasury Rate shall be interpolated or
extrapolated from those yields on a straight line basis, rounding to the nearest month; or (2) if such release (or any successor
release) is not published during the week preceding the calculation date or does not contain such yields, the rate per year equal
to the semiannual equivalent yield to maturity of the Comparable Treasury Issue, calculated using a price for the Comparable Treasury
Issue (expressed as a percentage of its principal amount) equal to the Comparable Treasury Price for such Redemption Date. The
Treasury Rate shall be calculated on the third Business Day preceding the Redemption Date.


 


Special Mandatory Redemption 


 


If (i)
the consummation of the Acquisition (as defined below) does not occur on or before January 30, 2021 or (ii) the Company notifies
the Trustee that the Company will not pursue the consummation of the Acquisition (each of (i) and (ii), a “Special Mandatory
Redemption Trigger”), the Company will be required to redeem the Securities of this series then outstanding (such redemption,
the “Special Mandatory Redemption”) at a redemption price equal to 101% of the principal amount of such Securities
plus accrued and unpaid interest, if any, to, but not including, the Special Mandatory Redemption Date (the “Special Mandatory
Redemption Price”). The “Acquisition” means the acquisition by the Company of Allergan plc and its
subsidiaries pursuant to the definitive transaction agreement, dated as of June 25, 2019, by and among the Company, Venice Subsidiary
LLC, a Delaware limited liability company and a direct wholly owned subsidiary of the Company, and Allergan plc, as amended from
time to time.


 


In the
event that the Company becomes obligated to redeem the Securities of this series pursuant to the Special Mandatory Redemption,
the Company will promptly, and in any event not more than five Business Days after the date on which a Special Mandatory Redemption
Trigger occurred, deliver notice to the Trustee of the Special Mandatory Redemption and the date upon which the Securities of this
series will be redeemed (the “Special Mandatory Redemption Date,” which date shall be no later than the third
Business Day following the date of such notice) together with a notice of Special Mandatory Redemption for the Trustee to deliver
to each registered holder of the Securities of this series to be redeemed. The Trustee will then promptly mail, or electronically
deliver, according to the procedures of DTC, such notice of Special Mandatory Redemption to each registered holder of the Securities
of this series to be redeemed. Unless the Company defaults in payment of the Special Mandatory Redemption Price, on and after such
Special Mandatory Redemption Date, interest will cease to accrue on the Securities of this series to be redeemed.


 


Failure to comply in any material respect
with any obligations in the provisions described under this caption “Special Mandatory Redemption” shall constitute
an “Event of Default” under Section 5.1(7) of the Indenture.


 






    A-4-9


     


    

 


Notwithstanding the foregoing, installments
of interest on the Securities of this series that are due and payable on Interest Payment Dates falling on or prior to the Special
Mandatory Redemption Date will be payable on such Interest Payment Dates to the Holder as of the close of business on the relevant
Record Dates in accordance with the Securities of this series and the Indenture.


 


For the avoidance of doubt, Article Eleven
of the Indenture shall not apply to the Special Mandatory Redemption.


 


Sinking Fund 


 


The Securities of this series do not provide
for a sinking fund.


 


Default


 


If an Event of Default with respect to Securities
of this series shall occur and be continuing, the principal of the Securities of this series may be declared due and payable in
the manner and with the effect provided in the Indenture.


 


Miscellaneous


 


The Indenture contains provisions for defeasance
at any time of the entire indebtedness of this Security or certain restrictive covenants and Events of Default with respect to
this Security, in each case upon compliance with certain conditions set forth therein. Sections 13.2 and 13.3 of the Indenture
apply to the Securities of this series.


 


The Indenture permits, with certain exceptions
as therein provided, the amendment thereof and the modification of the rights and obligations of the Company and the rights of
the Holders of the Securities of each series to be affected under the Indenture at any time by the Company and the Trustee with
the consent of the Holders of not less than a majority in principal amount of the Securities at the time Outstanding of each series
to be affected. The Indenture also contains provisions permitting the Holders of specified percentages in principal amount of the
Securities at the time Outstanding of any series, on behalf of the Holders of all Securities of such series, to waive compliance
by the Company with certain provisions of the Indenture and certain past defaults under the Indenture and their consequences. Any
such consent or waiver by the Holder of this Security shall be conclusive and binding upon such Holder and upon all future Holders
of this Security and of any Security issued upon the registration of transfer hereof or in exchange herefor or in lieu hereof,
whether or not notation of such consent or waiver is made upon this Security.


 


No reference herein to the Indenture or
Supplemental Indenture and no provision of this Security or of the Indenture or Supplemental Indenture shall alter or impair the
obligation of the Company, which is absolute and unconditional, to pay the principal of and any premium and interest on this Security
at the times, place and rate, and in the coin or currency, herein prescribed.


 






    A-4-10


     


    

 


As provided in the Indenture and subject
to certain limitations therein set forth, the transfer of this Security is registerable in the Security Register, upon surrender
of this Security for registration of transfer at the office or agency of the Company in any place where the principal of and any
premium and interest on this Security are payable, duly endorsed by, or accompanied by a written instrument of transfer in form
satisfactory to the Company and the Security Registrar duly executed by, the Holder hereof or his attorney duly authorized in writing,
and thereupon one or more new Securities of this series and of like tenor, of authorized denominations and for the same aggregate
principal amount, will be issued to the designated transferee or transferees.


 


The Securities of this series are issuable
only in registered form without coupons in denominations of $2,000 and any integral multiple of $1,000 in excess thereof. As provided
in the Indenture and subject to certain limitations therein set forth, Securities of this series are exchangeable for a like aggregate
principal amount of Securities of this series and of like tenor of a different authorized denomination, as requested by the Holder
surrendering the same.


 


No service charge shall be made for any
registration of transfer or exchange of the Notes, but the Company or the Security Registrar may require payment of a sum sufficient
to cover any transfer tax, assessments, or similar governmental charge payable in connection therewith (other than any such transfer
taxes, assessments or similar governmental charge payable upon exchange or transfer pursuant to Sections 9.6 or 11.7 of the Indenture).


 


Prior to due presentment of this Security
for registration of transfer, the Company, the Trustee and any agent of the Company or the Trustee will treat the Person in whose
name this Security is registered as the owner hereof for the purpose of receiving payments and for all other purposes, whether
or not this Security be overdue, and neither the Company, the Trustee nor any such agent shall be affected by notice to the contrary.


 


All terms used in this Security which are
defined in the Indenture and Supplemental Indenture shall have the meanings assigned to them in the Indenture and Supplemental
Indenture.


 


THIS SECURITY SHALL BE GOVERNED BY AND CONSTRUED
IN ACCORDANCE WITH THE LAWS OF THE STATE OF NEW YORK.


 


This Security is a Book-Entry Security within
the meaning of the Indenture hereinafter referred to and is registered in the name of a Depository or a nominee of a Depository.
This Security is exchangeable for Securities registered in the name of a person other than the Depository or its nominee only in
the limited circumstances described in the Indenture and may not be transferred except as a whole by the Depository to a nominee
of the Depository or by a nominee of the Depository to the Depository or another nominee of the Depository.


 


*                                           *                                           *


 






    A-4-11


     


    

 


SCHEDULE OF EXCHANGES


 


The following exchanges, redemptions or
purchases of a part of this Book-Entry Security have been made:


 


	Date of

Exchange/

Redemption/

Repurchase	Amount of

decrease in

Principal Amount

of this Book-

Entry

Security	Amount of

increase in

Principal Amount

of this Book-

Entry Security	Principal Amount

of this Book-

Entry

Security following

such decrease (or

increase)	Signature of

authorized

signatory of

Trustee
	 	 	 	 	 
	 	 	 	 	 
	 	 	 	 	 



 






    A-4-12


     


    

 


ASSIGNMENT FORM


 


To assign this Security, fill in the form below:


 


I or we assign and transfer this Security to


 


 


	 
	(Print or type assignee’s name, address and zip code)


 


 


	 
	(Insert assignee’s soc. sec. or tax I.D. No.)


 


and irrevocably appoint                               
as agent to transfer this Security on the books of the Company. The agent may substitute another to act for him.


 


 


	Date:	 
	 	 
	Your Signature*:	 
	 	 
	By:	 
	 	 
	Name:	 
	 	 
	Title:	 




 


Sign exactly as your name appears on the
other side of this Security.


 


*Signature Guaranteed:


 


*NOTICE: The signature to this assignment must correspond with
the name as it appears upon the face of the within Note in every particular, without alteration, enlargement or any change whatever.
Such signature must be guaranteed by an “eligible guarantor institution” meeting the requirements of the Security Registrar,
which requirements include membership or participation in Security Transfer Agents Medallion Program (“STAMP”) or such
other “signature guarantee program” as may be determined by the Security Registrar in addition to, or in substitution
for, STAMP, all in accordance with the Securities Exchange Act of 1934, as amended.


 






    A-4-13


     


    

 


FORM OF TRANSFER CERTIFICATE


 


In connection with any transfer of any of
the Securities evidenced by this certificate occurring prior to the expiration of the period referred to in Rule 144 under
the Securities Act (“Rule 144”) after the later of the date of original issuance of such Notes and the last date,
if any, on which such Notes were owned by the Company or any Affiliate (as such term is defined in Rule 144) of the Company,
the undersigned confirms that such Securities are being transferred in accordance with its terms:


 


CHECK ONE BOX BELOW


 


	(1)	 ̈  to the Company; or



 


	(2)	 ̈  pursuant to an effective registration statement under the Securities
                                 Act; or



 


	(3)	 ̈  inside the United States to a person reasonably believed to be a “qualified institutional buyer”
                                 (as defined in Rule 144A under the Securities Act) that purchases for its own account or for the account of a qualified
                                 institutional buyer to whom notice is given that such transfer is being made in reliance on Rule 144A, in each case pursuant
                                 to and in compliance with Rule 144A under the Securities Act; or



 


	(4)	 ̈  in an offshore transaction in compliance with Rule 903 or Rule 904 of Regulation S under the Securities Act;
                                 or



 


	(5)	 ̈  pursuant to the exemption from registration provided by Rule 144 under the Securities Act or any other
                                 available exemption from the registration requirement of the Securities Act.



 


Unless one of the boxes is checked,
the Trustee shall refuse to register any of the Securities evidenced by this certificate in the name of any person other than the
registered holder thereof; provided, however, that if box (5) is checked, the Trustee shall be entitled to require, prior
to registering any such transfer of the Securities, such legal opinions, certifications and other information as the Company has
reasonably requested to confirm that such transfer is being made pursuant to an exemption from, or in a transaction not subject
to, the registration requirements of the Securities Act.


 


 


	 	 
	 	Signature




 






    A-4-14


     


    

 


TO BE COMPLETED
BY PURCHASER IF (3) ABOVE IS CHECKED.


 


The undersigned represents and warrants that it is purchasing
this Security for its own account or an account with respect to which it exercises sole investment discretion and that it and any
such account is a “qualified institutional buyer” within the meaning of Rule 144A under the Securities Act, and is
aware that the sale to it is being made in reliance on Rule 144A and acknowledges that it has received such information regarding
the Company as the undersigned has requested pursuant to Rule 144A or has determined not to request such information and that it
is aware that the transferor is relying upon the undersigned’s foregoing representations in order to claim the exemption
from registration provided by Rule 144A.


 


 


	Dated:	 	 	Notice: To be executed by an executive officer




 






    A-4-15


     


    

 


FORM OF EXCHANGE CERTIFICATE


 


AbbVie Inc.


1 North Waukegan Road


North Chicago, Illinois 60064


 


U.S. Bank National Association


190 South LaSalle Street, 10th Floor


Chicago, IL 60603


Attention: Corporate Trust Services


 


Re: 2.150% Senior Notes due
2021


 


Reference is hereby made to the Indenture,
dated as of November 8, 2012 (the “Base Indenture”), as supplemented by the First Supplemental Indenture, dated as
of November 8, 2012, the Second Supplemental Indenture, dated as of May 14, 2015, the Third Supplemental Indenture, dated as of
May 12, 2016, the Fourth Supplemental Indenture, dated as of November 17, 2016, the Fifth Supplemental Indenture, dated as of September
18, 2018, the Sixth Supplemental Indenture, dated as of September 26, 2019 and the Seventh Supplemental Indenture, dated as of
November 21, 2019 (as so supplemented, the “Indenture”), between AbbVie Inc. (the “Company”) and U.S. Bank
National Association, a national banking association as trustee. Capitalized terms used but not defined herein shall have the meanings
given to them in the Indenture.


 


                          
(the “Owner”) owns and proposes to exchange the Security[ies] or interest in such Security[ies] specified herein,
in the principal amount of $                    
in such Security[ies] or interests (the “Exchange”). In connection with the Exchange, the Owner hereby certifies
that in connection with the Exchange of the Owner’s Regulation S Global Note for a beneficial interest in the Rule 144A
Global Note, with an equal principal amount, the Security[ies] or interest in such Security[ies] specified herein [is][are] being
transferred to a Person (A) who the transferor reasonably believes to be a QIB, (B) purchasing for its own account or the account
of a QIB in a transaction meeting the requirements of Rule 144A, and (C) in accordance with all applicable securities laws of
the States of the United States and other jurisdictions.


 


This certificate and the statements contained
herein are made for your benefit and the benefit of the Company and are dated ___________.


 


	 	 	 	[Insert Name of Transferor]
	 	 	 	 
	 	 	 	By:	 
	 	 	 	 	Name:
	 	 	 	 	Title:
	Dated:	 	 	 	 











 






    A-4-16


     


    

 


 


EXHIBIT A5


 


(FORM OF FACE OF INITIAL NOTE)


 


[THIS SECURITY IS A GLOBAL SECURITY WITHIN THE MEANING OF THE
INDENTURE HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME OF A DEPOSITARY OR A NOMINEE OF A DEPOSITARY. UNLESS AND UNTIL
IT IS EXCHANGED IN WHOLE OR IN PART FOR SECURITIES IN DEFINITIVE FORM IN ACCORDANCE WITH THE PROVISIONS OF THE INDENTURE AND THE
TERMS OF THE SECURITIES, TRANSFERS OF THIS GLOBAL SECURITY SHALL BE LIMITED TO TRANSFERS IN WHOLE, BUT NOT IN PART, TO THE DEPOSITORY
TRUST COMPANY, A NEW YORK CORPORATION (“DTC”), TO NOMINEES OF DTC OR TO A SUCCESSOR THEREOF OR SUCH SUCCESSOR’S
NOMINEE AND TRANSFERS OF PORTIONS OF THIS GLOBAL SECURITY SHALL BE LIMITED TO TRANSFERS MADE IN ACCORDANCE WITH THE RESTRICTIONS
SET FORTH IN THE INDENTURE REFERRED TO ON THE REVERSE HEREOF.


 


UNLESS THIS CERTIFICATE IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE
OF DTC, TO ABBVIE INC., OR ITS AGENT FOR REGISTRATION OF TRANSFER, EXCHANGE OR PAYMENT, AND ANY CERTIFICATE ISSUED IS REGISTERED
IN THE NAME OF CEDE & CO. OR IN SUCH OTHER NAME AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC (AND ANY PAYMENT IS
MADE TO CEDE & CO. OR TO SUCH OTHER ENTITY AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC), ANY TRANSFER, PLEDGE OR
OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL INASMUCH AS THE REGISTERED OWNER HEREOF, CEDE & CO.,
HAS AN INTEREST HEREIN.](1)


 


THIS SECURITY HAS NOT BEEN REGISTERED UNDER THE SECURITIES ACT
OF 1933, AS AMENDED (THE “SECURITIES ACT”), OR THE SECURITIES LAWS OF ANY STATE OR OTHER JURISDICTION.


 


NEITHER THIS SECURITY NOR ANY INTEREST OR PARTICIPATION
HEREIN MAY BE REOFFERED, SOLD, ASSIGNED, TRANSFERRED, PLEDGED, ENCUMBERED OR OTHERWISE DISPOSED OF IN THE ABSENCE OF SUCH
REGISTRATION OR UNLESS SUCH TRANSACTION IS EXEMPT FROM, OR NOT SUBJECT TO, SUCH REGISTRATION. THE HOLDER OF THIS SECURITY, BY
ITS ACCEPTANCE HEREOF, AGREES ON ITS OWN BEHALF AND ON BEHALF OF ANY INVESTOR ACCOUNT FOR WHICH IT HAS PURCHASED SECURITIES,
TO OFFER, SELL OR OTHERWISE TRANSFER SUCH SECURITY, PRIOR TO THE DATE (THE “RESALE RESTRICTION TERMINATION DATE”)
THAT IS [IN THE CASE OF RULE 144A NOTES: ONE YEAR] [IN THE CASE OF REGULATION S NOTES: 40 DAYS] AFTER THE LATER OF THE ISSUE
DATE HEREOF OR ANY OTHER ISSUE DATE IN RESPECT OF A FURTHER ISSUANCE OF SECURITIES OF THE SAME SERIES AND THE LAST DATE ON
WHICH ABBVIE INC. OR ANY AFFILIATE OF ABBVIE INC. WAS THE OWNER OF THIS SECURITY (OR ANY PREDECESSOR OF SUCH SECURITY), ONLY
(A) TO ABBVIE INC. OR ANY SUBSIDIARY THEREOF, (B) PURSUANT TO A REGISTRATION STATEMENT THAT HAS BEEN DECLARED
EFFECTIVE UNDER THE SECURITIES ACT, (C) FOR SO LONG AS THE SECURITIES ARE ELIGIBLE FOR RESALE PURSUANT TO RULE 144A
UNDER THE SECURITIES ACT (“RULE 144A”), TO A PERSON IT REASONABLY BELIEVES IS A ‘‘QUALIFIED
INSTITUTIONAL BUYER’’ AS DEFINED IN RULE 144A THAT PURCHASES FOR ITS OWN ACCOUNT OR FOR THE ACCOUNT OF A
QUALIFIED INSTITUTIONAL BUYER TO WHOM NOTICE IS GIVEN THAT THE TRANSFER IS BEING MADE IN RELIANCE ON RULE 144A IN A
TRANSACTION MEETING THE REQUIREMENTS OF RULE 144A, (D) PURSUANT TO OFFERS AND SALES TO NON-U.S. PERSONS THAT OCCUR
OUTSIDE THE UNITED STATES WITHIN THE MEANING OF REGULATION S UNDER THE SECURITIES ACT, (E) TO AN INSTITUTIONAL
 “ACCREDITED INVESTOR” WITHIN THE MEANING OF RULE 501(a)(1), (2), (3) OR (7) UNDER THE SECURITIES ACT THAT IS
NOT A QUALIFIED INSTITUTIONAL BUYER AND THAT IS PURCHASING FOR ITS OWN ACCOUNT OR FOR THE ACCOUNT OF ANOTHER INSTITUTIONAL
ACCREDITED INVESTOR, IN EACH CASE IN A MINIMUM PRINCIPAL AMOUNT OF THE SECURITIES OF $250,000, FOR INVESTMENT PURPOSES AND
NOT WITH A VIEW TO OR FOR OFFER OR SALE IN CONNECTION WITH ANY DISTRIBUTION IN VIOLATION OF THE SECURITIES ACT
OR (F) PURSUANT TO ANOTHER AVAILABLE EXEMPTION FROM THE REGISTRATION REQUIREMENTS OF THE SECURITIES ACT, SUBJECT TO
ABBVIE INC.’S AND THE TRUSTEE’S RIGHT PRIOR TO ANY SUCH OFFER, SALE OR TRANSFER PURSUANT TO CLAUSES (D), (E)
OR (F) TO REQUIRE THE DELIVERY OF AN OPINION OF COUNSEL, CERTIFICATION AND/OR OTHER INFORMATION SATISFACTORY TO EACH OF
THEM.


 






    A-5-1


     


    

 


[EACH PURCHASER OF THIS SECURITY IS HEREBY NOTIFIED THAT THE
SELLER OF THIS SECURITY MAY BE RELYING ON THE EXEMPTION FROM THE PROVISIONS OF SECTION 5 OF THE SECURITIES ACT PROVIDED BY
RULE 144A THEREUNDER.](2)


 


[BY ITS ACQUISITION HEREOF, THE HOLDER HEREOF REPRESENTS THAT
IT IS NOT A U.S. PERSON NOR IS IT PURCHASING FOR THE ACCOUNT OF A U.S. PERSON AND IS ACQUIRING THIS SECURITY IN AN OFFSHORE TRANSACTION
IN ACCORDANCE WITH REGULATION S UNDER THE SECURITIES ACT.](3)


 


[IN CONNECTION WITH ANY TRANSFER, THE HOLDER WILL DELIVER TO
THE REGISTRAR AND TRANSFER AGENT SUCH CERTIFICATES AND OTHER INFORMATION AS SUCH TRANSFER AGENT MAY REASONABLY REQUIRE TO CONFIRM
THAT THE TRANSFER COMPLIES WITH THE FOREGOING RESTRICTIONS.](4)


 


(1) Applies to Global Notes only


 


(2) Applies to Rule 144A Notes only


 


(3) Applies to Regulation S Notes only


 


(4) Applies to Notes in definitive form
only


 






    A-5-2


     


    

 


ABBVIE INC.


 


2.300% Senior Notes due 2022


 


 


 


	No. [●]	$[●]


 


CUSIP No: [●]


 


ISIN No: [●]


 


ABBVIE INC., a corporation duly organized
and existing under the laws of Delaware (herein called the “Company,” which term includes any successor Person
under the Indenture and Supplemental Indenture hereinafter referred to), for value received, hereby promises to pay to Cede &
Co., as nominee for The Depository Trust Company, or registered assigns, the principal sum of [●] Dollars ($[●]), or
such other principal sum as may be indicated on the Schedule of Exchanges attached hereto, on November 21, 2022, and to pay interest
thereon from November 21, 2019 or from the most recent Interest Payment Date to which interest has been paid or duly provided for,
semi-annually in arrears on May 21 and November 21 of each year, commencing on May 21, 2020, at the rate of 2.300% per annum, until
the principal hereof is paid or made available for payment. The interest so payable, and punctually paid or duly provided for,
on any Interest Payment Date will, as provided in such Indenture, be paid to the Person in whose name this Security (or one or
more Predecessor Securities) is registered at the close of business on the Regular Record Date for such interest, which shall be
the date that is 15 calendar days prior to the relevant Interest Payment Date (whether or not a Business Day). Any such interest
not so punctually paid or duly provided for will forthwith cease to be payable to the Holder on such Regular Record Date and may
either be paid to the Person in whose name this Security (or one or more Predecessor Securities) is registered at the close of
business on a Special Record Date for the payment of such Defaulted Interest to be fixed by the Trustee, notice whereof shall be
given to Holders of Securities of this series not less than 10 days prior to such Special Record Date, or be paid at any time in
any other lawful manner not inconsistent with the requirements of any securities exchange on which the Securities of this series
may be listed, and upon such notice as may be required by such exchange, all as more fully provided in said Indenture.


 


Payment of the principal of (and
premium, if any) and any such interest on this Security will be made at the office or agency of the Company maintained for
that purpose in St. Paul, Minnesota, in such coin or currency of the United States of America as at the time of payment is
legal tender for payment of public and private debts; provided, however, that at the option of the Company payment of
interest may be made by (1) check mailed to the address of the Person entitled thereto as such address shall appear in
the Security Register or (2) wire transfer as directed by the Holder, in immediately available funds to an account
maintained by the Depository or its nominee with respect to a Global Note, and to the Holder or its nominee with respect to a
Definitive Note; provided further that in the case of a Definitive Note (1) the Holder thereof shall have provided
written wiring instructions to the Trustee on or before the related Regular Record Date and (2) if appropriate
instructions for any such wire transfer are not received by the related Regular Record Date, then such payment shall be made
by check mailed to the address of the Holder specified in the Security Register.


 






    A-5-3


     


    

 


Reference is hereby made to the further
provisions of this Security set forth on the reverse hereof, which further provisions shall for all purposes have the same effect
as if set forth at this place.


 


Unless the certificate of authentication
hereon has been executed by the Trustee referred to herein by manual signature, this Security shall not be entitled to any benefit
under the Indenture or be valid or obligatory for any purpose.


 



    A-5-4


     


    




 


IN WITNESS WHEREOF, the Company has caused
this instrument to be duly executed.


 


Dated: November 21, 2019


 


 


	 	ABBVIE INC.
	 	 
	 	By:	 
	 	 	Name:
	 	 	Title:




 



    A-5-5


     


    




 


TRUSTEE’S CERTIFICATE OF AUTHENTICATION


 


This is one of the Securities of the series
designated therein referred to in the within-mentioned Indenture.


 


Dated: November 21, 2019


 


 


	 	U.S. BANK NATIONAL ASSOCIATION,
	 	 	as Trustee
	 	 
	 	By:	 
	 	 	Authorized Signatory




 



    A-5-6


     


    




 


[FORM OF REVERSE OF SECURITY]


 


This Security is one of a duly authorized
issue of securities of the Company (herein called the “Securities”), issued and to be issued in one or more
series under an Indenture, dated as of November 8, 2012, as it may be supplemented or amended from time to time (herein called
the “Indenture”), between the Company and U.S. Bank National Association, as Trustee (herein called the “Trustee,”
which term includes any successor trustee under the Indenture), and Supplemental Indenture No. 7, dated as of November 21,
2019 (herein called the “Supplemental Indenture”), between the Company and the Trustee, to which Indenture,
Supplemental Indenture and all indentures supplemental thereto reference is hereby made for a statement of the respective rights,
limitations of rights, duties and immunities thereunder of the Company, the Trustee and the Holders of the Securities of this series
and of the terms upon which the Securities of this series are, and are to be, authenticated and delivered. This Security is one
of the series designated on the face hereof, in an initial aggregate principal amount of $[●].


 


Optional Redemption 


 


At any time prior to the Maturity Date (as
defined below), the Company may redeem some or all of the Securities of this series at its option, in each case at a redemption
price equal to the greater of (i) 100% of the principal amount of the Securities of this series to be redeemed; and (ii) the sum
of the present values of the remaining scheduled payments through the Maturity Date of principal and interest on the Securities
of this series to be redeemed (exclusive of interest accrued to the Redemption Date) discounted to the Redemption Date on a semiannual
basis (assuming a 360-day year consisting of twelve 30-day months) at the then current Treasury Rate, plus 10 basis points.


 


The Company will pay accrued and unpaid
interest on the principal amount of the Securities of this series being redeemed to, but excluding, the Redemption Date.


 


If the Company has given notice as provided
in the Indenture and funds for the redemption of any Securities of this series called for redemption have been made available on
the Redemption Date in accordance with the Indenture, such Securities will cease to bear interest on the date fixed for redemption.
Thereafter, the only right of the Holders of such Securities will be to receive payment of the redemption price.


 


The Company will give notice of any
optional redemption, electronically or by mail, to Holders at their addresses, as shown in the Security Register for such
Securities, or as otherwise in accordance with the applicable procedures of DTC, not more than 60 nor less than 15 days prior
to the date fixed for redemption. The notice of redemption will specify, among other items, the Redemption Date, redemption
price, the principal amount of the Securities of this series to be redeemed and the place or places that payment will be made
upon surrender of the Securities of this series to be redeemed. Any redemption or notice of redemption may, at the
Company’s discretion, be subject to one or more conditions precedent, and, at the Company’s discretion, the
redemption date may be delayed until such time as any or all such conditions shall be satisfied. The Company shall provide
written notice to the Trustee prior to the close of business two Business Days prior to the redemption date if any such
redemption has been rescinded or delayed, and upon receipt the Trustee shall provide such notice to each holder of the
Securities in the same manner in which the notice of redemption was given.


 






    A-5-7


     


    

 


The Company will notify the Trustee at least
30 days prior to the Redemption Date fixed by the Company (or such shorter period as is satisfactory to the Trustee) of the aggregate
principal amount of the Securities of this series to be redeemed and their Redemption Date. If less than all of the Securities
of this series are to be redeemed at any time, the Trustee shall select, not more than 30 days prior to the Redemption Date, which
Securities or the portion thereof, that are to be redeemed from the outstanding Securities of this series not previously redeemed
by random lot.


 


“Comparable Treasury Issue”
means the United States Treasury security selected by the Independent Investment Banker as having a maturity comparable to the
remaining term (“Remaining Life”) of the Securities of this series to be redeemed that would be utilized, at the time
of selection and in accordance with customary financial practice, in pricing new issues of corporate debt securities of comparable
maturity to the Remaining Life of such Securities.


 


“Comparable Treasury Price”
means, with respect to any Redemption Date, (1) if the Company obtains four or more Reference Treasury Dealer Quotations for
such Redemption Date, the average of such Reference Treasury Dealer Quotations, after excluding the highest and lowest Reference
Treasury Dealer Quotations, or (2) if the Company obtains fewer than four such Reference Treasury Dealer Quotations, the average
of all such quotations.


 


“Independent Investment Banker”
means one of the Reference Treasury Dealers that the Company appoints to act as the Independent Investment Banker from time to
time.


 


“Business Day” means
any calendar day that is not a Saturday, Sunday or legal holiday in New York, New York and on which commercial banks are open for
business in New York, New York.


 


“Maturity Date” means
November 21, 2022.


 


“Primary Treasury Dealer”
means a primary United States government securities dealer in the United States of America.


 


“Reference Treasury Dealer”
means (i) each of Morgan Stanley & Co. LLC, BofA Securities, Inc., Barclays Capital Inc. and any of their respective successors;
provided, however, that if any of them ceases to be a Primary Treasury Dealer, the Company will substitute therefor another Primary
Treasury Dealer and (ii) any other Primary Treasury Dealers the Company selects.


 


“Reference Treasury Dealer Quotations”
means, with respect to each Reference Treasury Dealer and any Redemption Date, the average, as determined by the Company, of the
bid and asked prices for the Comparable Treasury Issue (expressed in each case as a percentage of its principal amount) quoted
in writing to the Company by such Reference Treasury Dealer at 3:30 p.m., New York City time, on the third Business Day preceding
such Redemption Date.


 


“Treasury Rate”
means, with respect to any Redemption Date, (1) the rate per annum equal to the yield, under the heading which
represents the average for the immediately preceding week, appearing in the most recently published statistical release
designated “H.15(519)” or any successor publication which is published weekly by the Board of Governors of the
Federal Reserve System and which establishes yields on actively traded United States Treasury securities adjusted to constant
maturity under the caption “Treasury Constant Maturities” for the maturity corresponding to the Comparable
Treasury Issue; provided that, if no maturity is within three months before or after the Remaining Life of the Securities of
this series to be redeemed, yields for the two published maturities most closely corresponding to the Comparable Treasury
Issue shall be determined and the Treasury Rate shall be interpolated or extrapolated from those yields on a straight line
basis, rounding to the nearest month; or (2) if such release (or any successor release) is not published during the week
preceding the calculation date or does not contain such yields, the rate per year equal to the semiannual equivalent yield to
maturity of the Comparable Treasury Issue, calculated using a price for the Comparable Treasury Issue (expressed as a
percentage of its principal amount) equal to the Comparable Treasury Price for such Redemption Date. The Treasury Rate shall
be calculated on the third Business Day preceding the Redemption Date.


 






    A-5-8


     


    

 


Special Mandatory Redemption 


 


If (i)
the consummation of the Acquisition (as defined below) does not occur on or before January 30, 2021 or (ii) the Company notifies
the Trustee that the Company will not pursue the consummation of the Acquisition (each of (i) and (ii), a “Special Mandatory
Redemption Trigger”), the Company will be required to redeem the Securities of this series then outstanding (such redemption,
the “Special Mandatory Redemption”) at a redemption price equal to 101% of the principal amount of such Securities
plus accrued and unpaid interest, if any, to, but not including, the Special Mandatory Redemption Date (the “Special Mandatory
Redemption Price”). The “Acquisition” means the acquisition by the Company of Allergan plc and its
subsidiaries pursuant to the definitive transaction agreement, dated as of June 25, 2019, by and among the Company, Venice Subsidiary
LLC, a Delaware limited liability company and a direct wholly owned subsidiary of the Company, and Allergan plc, as amended from
time to time.


 


In the
event that the Company becomes obligated to redeem the Securities of this series pursuant to the Special Mandatory Redemption,
the Company will promptly, and in any event not more than five Business Days after the date on which a Special Mandatory Redemption
Trigger occurred, deliver notice to the Trustee of the Special Mandatory Redemption and the date upon which the Securities of this
series will be redeemed (the “Special Mandatory Redemption Date,” which date shall be no later than the third
Business Day following the date of such notice) together with a notice of Special Mandatory Redemption for the Trustee to deliver
to each registered holder of the Securities of this series to be redeemed. The Trustee will then promptly mail, or electronically
deliver, according to the procedures of DTC, such notice of Special Mandatory Redemption to each registered holder of the Securities
of this series to be redeemed. Unless the Company defaults in payment of the Special Mandatory Redemption Price, on and after such
Special Mandatory Redemption Date, interest will cease to accrue on the Securities of this series to be redeemed.


 


Failure to comply in any material respect
with any obligations in the provisions described under this caption “Special Mandatory Redemption” shall constitute
an “Event of Default” under Section 5.1(7) of the Indenture.


 






    A-5-9


     


    

 


Notwithstanding the foregoing, installments
of interest on the Securities of this series that are due and payable on Interest Payment Dates falling on or prior to the Special
Mandatory Redemption Date will be payable on such Interest Payment Dates to the Holder as of the close of business on the relevant
Record Dates in accordance with the Securities of this series and the Indenture.


 


For the avoidance of doubt, Article Eleven
of the Indenture shall not apply to the Special Mandatory Redemption.


 


Sinking Fund 


 


The Securities of this series do not provide
for a sinking fund.


 


Default


 


If an Event of Default with respect to Securities
of this series shall occur and be continuing, the principal of the Securities of this series may be declared due and payable in
the manner and with the effect provided in the Indenture.


 


Miscellaneous


 


The Indenture contains provisions for defeasance
at any time of the entire indebtedness of this Security or certain restrictive covenants and Events of Default with respect to
this Security, in each case upon compliance with certain conditions set forth therein. Sections 13.2 and 13.3 of the Indenture
apply to the Securities of this series.


 


The Indenture permits, with certain exceptions
as therein provided, the amendment thereof and the modification of the rights and obligations of the Company and the rights of
the Holders of the Securities of each series to be affected under the Indenture at any time by the Company and the Trustee with
the consent of the Holders of not less than a majority in principal amount of the Securities at the time Outstanding of each series
to be affected. The Indenture also contains provisions permitting the Holders of specified percentages in principal amount of the
Securities at the time Outstanding of any series, on behalf of the Holders of all Securities of such series, to waive compliance
by the Company with certain provisions of the Indenture and certain past defaults under the Indenture and their consequences. Any
such consent or waiver by the Holder of this Security shall be conclusive and binding upon such Holder and upon all future Holders
of this Security and of any Security issued upon the registration of transfer hereof or in exchange herefor or in lieu hereof,
whether or not notation of such consent or waiver is made upon this Security.


 


No reference herein to the Indenture or
Supplemental Indenture and no provision of this Security or of the Indenture or Supplemental Indenture shall alter or impair the
obligation of the Company, which is absolute and unconditional, to pay the principal of and any premium and interest on this Security
at the times, place and rate, and in the coin or currency, herein prescribed.


 






    A-5-10


     


    

 


As provided in the Indenture and subject
to certain limitations therein set forth, the transfer of this Security is registerable in the Security Register, upon surrender
of this Security for registration of transfer at the office or agency of the Company in any place where the principal of and any
premium and interest on this Security are payable, duly endorsed by, or accompanied by a written instrument of transfer in form
satisfactory to the Company and the Security Registrar duly executed by, the Holder hereof or his attorney duly authorized in writing,
and thereupon one or more new Securities of this series and of like tenor, of authorized denominations and for the same aggregate
principal amount, will be issued to the designated transferee or transferees.


 


The Securities of this series are issuable
only in registered form without coupons in denominations of $2,000 and any integral multiple of $1,000 in excess thereof. As provided
in the Indenture and subject to certain limitations therein set forth, Securities of this series are exchangeable for a like aggregate
principal amount of Securities of this series and of like tenor of a different authorized denomination, as requested by the Holder
surrendering the same.


 


No service charge shall be made for any
registration of transfer or exchange of the Notes, but the Company or the Security Registrar may require payment of a sum sufficient
to cover any transfer tax, assessments, or similar governmental charge payable in connection therewith (other than any such transfer
taxes, assessments or similar governmental charge payable upon exchange or transfer pursuant to Sections 9.6 or 11.7 of the Indenture).


 


Prior to due presentment of this Security
for registration of transfer, the Company, the Trustee and any agent of the Company or the Trustee will treat the Person in whose
name this Security is registered as the owner hereof for the purpose of receiving payments and for all other purposes, whether
or not this Security be overdue, and neither the Company, the Trustee nor any such agent shall be affected by notice to the contrary.


 


All terms used in this Security which are
defined in the Indenture and Supplemental Indenture shall have the meanings assigned to them in the Indenture and Supplemental
Indenture.


 


THIS SECURITY SHALL BE GOVERNED BY AND CONSTRUED
IN ACCORDANCE WITH THE LAWS OF THE STATE OF NEW YORK.


 


This Security is a Book-Entry Security within
the meaning of the Indenture hereinafter referred to and is registered in the name of a Depository or a nominee of a Depository.
This Security is exchangeable for Securities registered in the name of a person other than the Depository or its nominee only in
the limited circumstances described in the Indenture and may not be transferred except as a whole by the Depository to a nominee
of the Depository or by a nominee of the Depository to the Depository or another nominee of the Depository.


 


*                                     *                                     *




 






    A-5-11


     


    

 


SCHEDULE OF EXCHANGES


 


The following exchanges, redemptions or
purchases of a part of this Book-Entry Security have been made:


 


	Date of

Exchange/

Redemption/

Repurchase	Amount of

decrease in

Principal Amount

of this Book-

Entry

Security	Amount of

increase in

Principal Amount

of this Book-

Entry Security	Principal Amount

of this Book-

Entry

Security following

such decrease (or

increase)	Signature of

authorized

signatory of

Trustee
	 	 	 	 	 
	 	 	 	 	 
	 	 	 	 	 



 






    A-5-12


     


    

 


ASSIGNMENT FORM


 


To assign this Security, fill in the form below:


 


I or we assign and transfer this Security to


 


	 
	(Print or type assignee’s name, address and zip code)





	 
	(Insert assignee’s soc. sec. or tax I.D. No.)


and irrevocably appoint                               
as agent to transfer this Security on the books of the Company. The agent may substitute another to act for him.


 


	Date:	 
	 	 
	Your Signature*:	 
	 	 
	By:	 
	 	 
	Name:	 
	 	 
	Title:	 




 


Sign exactly as your name appears on the
other side of this Security.


  


*Signature Guaranteed:


 


*NOTICE: The signature to this assignment must correspond with
the name as it appears upon the face of the within Note in every particular, without alteration, enlargement or any change whatever.
Such signature must be guaranteed by an “eligible guarantor institution” meeting the requirements of the Security Registrar,
which requirements include membership or participation in Security Transfer Agents Medallion Program (“STAMP”) or such
other “signature guarantee program” as may be determined by the Security Registrar in addition to, or in substitution
for, STAMP, all in accordance with the Securities Exchange Act of 1934, as amended.



 






    A-5-13


     


    

 


FORM OF TRANSFER CERTIFICATE


 


In connection with any transfer of any of
the Securities evidenced by this certificate occurring prior to the expiration of the period referred to in Rule 144 under
the Securities Act (“Rule 144”) after the later of the date of original issuance of such Notes and the last date,
if any, on which such Notes were owned by the Company or any Affiliate (as such term is defined in Rule 144) of the Company,
the undersigned confirms that such Securities are being transferred in accordance with its terms:


 


CHECK ONE BOX BELOW


 


		(1)	 ̈to the Company; or



 


		(2)	 ̈pursuant to an effective registration statement under the Securities Act; or



 


		(3)	 ̈inside the United States to a person reasonably believed to be a “qualified institutional buyer” (as
defined in Rule 144A under the Securities Act) that purchases for its own account or for the account of a qualified institutional
buyer to whom notice is given that such transfer is being made in reliance on Rule 144A, in each case pursuant to and in compliance
with Rule 144A under the Securities Act; or



 


		(4)	 ̈in an offshore transaction in compliance with Rule 903 or Rule 904 of Regulation S under the Securities Act; or



 


		(5)	 ̈pursuant to the exemption from registration provided by Rule 144 under the Securities Act or any other available
exemption from the registration requirement of the Securities Act.



 


Unless one of the boxes is checked,
the Trustee shall refuse to register any of the Securities evidenced by this certificate in the name of any person other than the
registered holder thereof; provided, however, that if box (5) is checked, the Trustee shall be entitled to require, prior
to registering any such transfer of the Securities, such legal opinions, certifications and other information as the Company has
reasonably requested to confirm that such transfer is being made pursuant to an exemption from, or in a transaction not subject
to, the registration requirements of the Securities Act.


 


	 	 
	 	Signature




 



    A-5-14


     


    




 


TO BE COMPLETED
BY PURCHASER IF (3) ABOVE IS CHECKED.


 


The undersigned represents and warrants that it is purchasing
this Security for its own account or an account with respect to which it exercises sole investment discretion and that it and any
such account is a “qualified institutional buyer” within the meaning of Rule 144A under the Securities Act, and is
aware that the sale to it is being made in reliance on Rule 144A and acknowledges that it has received such information regarding
the Company as the undersigned has requested pursuant to Rule 144A or has determined not to request such information and that it
is aware that the transferor is relying upon the undersigned’s foregoing representations in order to claim the exemption
from registration provided by Rule 144A.


 


	Dated:		 	Notice: To be executed by an executive officer




 






    A-5-15


     


    

 


FORM OF EXCHANGE CERTIFICATE


 


AbbVie Inc.


1 North Waukegan Road


North Chicago, Illinois 60064


 


U.S. Bank National Association


190 South LaSalle Street, 10th Floor


Chicago, IL 60603


Attention: Corporate Trust Services


 


Re: 2.300% Senior Notes due
2022


 


Reference is hereby made to the Indenture,
dated as of November 8, 2012 (the “Base Indenture”), as supplemented by the First Supplemental Indenture, dated as
of November 8, 2012, the Second Supplemental Indenture, dated as of May 14, 2015, the Third Supplemental Indenture, dated as of
May 12, 2016, the Fourth Supplemental Indenture, dated as of November 17, 2016, the Fifth Supplemental Indenture, dated as of September
18, 2018, the Sixth Supplemental Indenture, dated as of September 26, 2019 and the Seventh Supplemental Indenture, dated as of
November 21, 2019 (as so supplemented, the “Indenture”), between AbbVie Inc. (the “Company”) and U.S. Bank
National Association, a national banking association as trustee. Capitalized terms used but not defined herein shall have the meanings
given to them in the Indenture.


 


                         (the
 “Owner”) owns and proposes to exchange the Security[ies] or interest in such Security[ies] specified herein, in the
principal amount of $                         
in such Security[ies] or interests (the “Exchange”). In connection with the Exchange, the Owner hereby certifies
that in connection with the Exchange of the Owner’s Regulation S Global Note for a beneficial interest in the Rule 144A
Global Note, with an equal principal amount, the Security[ies] or interest in such Security[ies] specified herein [is][are] being
transferred to a Person (A) who the transferor reasonably believes to be a QIB, (B) purchasing for its own account or the account
of a QIB in a transaction meeting the requirements of Rule 144A, and (C) in accordance with all applicable securities laws of
the States of the United States and other jurisdictions.


 


This certificate and the statements contained
herein are made for your benefit and the benefit of the Company and are dated ________________.


 


	 	 	[Insert Name of Transferor]
	 	 	 	 
	 	 	By:	 
	 	 	 	Name:
	 	 	 	Title:
	 	 	 	 
	Dated:		:	 	 	 




 



    A-5-16


     


    





 


EXHIBIT A6


 


(FORM OF FACE OF INITIAL NOTE)


 


[THIS SECURITY IS A GLOBAL SECURITY WITHIN THE MEANING OF THE
INDENTURE HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME OF A DEPOSITARY OR A NOMINEE OF A DEPOSITARY. UNLESS AND UNTIL
IT IS EXCHANGED IN WHOLE OR IN PART FOR SECURITIES IN DEFINITIVE FORM IN ACCORDANCE WITH THE PROVISIONS OF THE INDENTURE AND THE
TERMS OF THE SECURITIES, TRANSFERS OF THIS GLOBAL SECURITY SHALL BE LIMITED TO TRANSFERS IN WHOLE, BUT NOT IN PART, TO THE DEPOSITORY
TRUST COMPANY, A NEW YORK CORPORATION (“DTC”), TO NOMINEES OF DTC OR TO A SUCCESSOR THEREOF OR SUCH SUCCESSOR’S
NOMINEE AND TRANSFERS OF PORTIONS OF THIS GLOBAL SECURITY SHALL BE LIMITED TO TRANSFERS MADE IN ACCORDANCE WITH THE RESTRICTIONS
SET FORTH IN THE INDENTURE REFERRED TO ON THE REVERSE HEREOF.


 


UNLESS THIS CERTIFICATE IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE
OF DTC, TO ABBVIE INC., OR ITS AGENT FOR REGISTRATION OF TRANSFER, EXCHANGE OR PAYMENT, AND ANY CERTIFICATE ISSUED IS REGISTERED
IN THE NAME OF CEDE & CO. OR IN SUCH OTHER NAME AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC (AND ANY PAYMENT IS
MADE TO CEDE & CO. OR TO SUCH OTHER ENTITY AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC), ANY TRANSFER, PLEDGE OR
OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL INASMUCH AS THE REGISTERED OWNER HEREOF, CEDE & CO.,
HAS AN INTEREST HEREIN.](1)


 


THIS SECURITY HAS NOT BEEN REGISTERED UNDER THE SECURITIES ACT
OF 1933, AS AMENDED (THE “SECURITIES ACT”), OR THE SECURITIES LAWS OF ANY STATE OR OTHER JURISDICTION.


 


NEITHER THIS SECURITY NOR ANY INTEREST OR PARTICIPATION
HEREIN MAY BE REOFFERED, SOLD, ASSIGNED, TRANSFERRED, PLEDGED, ENCUMBERED OR OTHERWISE DISPOSED OF IN THE ABSENCE OF SUCH
REGISTRATION OR UNLESS SUCH TRANSACTION IS EXEMPT FROM, OR NOT SUBJECT TO, SUCH REGISTRATION. THE HOLDER OF THIS SECURITY, BY
ITS ACCEPTANCE HEREOF, AGREES ON ITS OWN BEHALF AND ON BEHALF OF ANY INVESTOR ACCOUNT FOR WHICH IT HAS PURCHASED SECURITIES,
TO OFFER, SELL OR OTHERWISE TRANSFER SUCH SECURITY, PRIOR TO THE DATE (THE “RESALE RESTRICTION TERMINATION DATE”)
THAT IS [IN THE CASE OF RULE 144A NOTES: ONE YEAR] [IN THE CASE OF REGULATION S NOTES: 40 DAYS] AFTER THE LATER OF THE ISSUE
DATE HEREOF OR ANY OTHER ISSUE DATE IN RESPECT OF A FURTHER ISSUANCE OF SECURITIES OF THE SAME SERIES AND THE LAST DATE ON
WHICH ABBVIE INC. OR ANY AFFILIATE OF ABBVIE INC. WAS THE OWNER OF THIS SECURITY (OR ANY PREDECESSOR OF SUCH SECURITY), ONLY
(A) TO ABBVIE INC. OR ANY SUBSIDIARY THEREOF, (B) PURSUANT TO A REGISTRATION STATEMENT THAT HAS BEEN DECLARED
EFFECTIVE UNDER THE SECURITIES ACT, (C) FOR SO LONG AS THE SECURITIES ARE ELIGIBLE FOR RESALE PURSUANT TO RULE 144A
UNDER THE SECURITIES ACT (“RULE 144A”), TO A PERSON IT REASONABLY BELIEVES IS A ‘‘QUALIFIED
INSTITUTIONAL BUYER’’ AS DEFINED IN RULE 144A THAT PURCHASES FOR ITS OWN ACCOUNT OR FOR THE ACCOUNT OF A
QUALIFIED INSTITUTIONAL BUYER TO WHOM NOTICE IS GIVEN THAT THE TRANSFER IS BEING MADE IN RELIANCE ON RULE 144A IN A
TRANSACTION MEETING THE REQUIREMENTS OF RULE 144A, (D) PURSUANT TO OFFERS AND SALES TO NON-U.S. PERSONS THAT OCCUR
OUTSIDE THE UNITED STATES WITHIN THE MEANING OF REGULATION S UNDER THE SECURITIES ACT, (E) TO AN INSTITUTIONAL
 “ACCREDITED INVESTOR” WITHIN THE MEANING OF RULE 501(a)(1), (2), (3) OR (7) UNDER THE SECURITIES ACT THAT IS
NOT A QUALIFIED INSTITUTIONAL BUYER AND THAT IS PURCHASING FOR ITS OWN ACCOUNT OR FOR THE ACCOUNT OF ANOTHER INSTITUTIONAL
ACCREDITED INVESTOR, IN EACH CASE IN A MINIMUM PRINCIPAL AMOUNT OF THE SECURITIES OF $250,000, FOR INVESTMENT PURPOSES AND
NOT WITH A VIEW TO OR FOR OFFER OR SALE IN CONNECTION WITH ANY DISTRIBUTION IN VIOLATION OF THE SECURITIES ACT
OR (F) PURSUANT TO ANOTHER AVAILABLE EXEMPTION FROM THE REGISTRATION REQUIREMENTS OF THE SECURITIES ACT, SUBJECT TO
ABBVIE INC.’S AND THE TRUSTEE’S RIGHT PRIOR TO ANY SUCH OFFER, SALE OR TRANSFER PURSUANT TO CLAUSES (D), (E)
OR (F) TO REQUIRE THE DELIVERY OF AN OPINION OF COUNSEL, CERTIFICATION AND/OR OTHER INFORMATION SATISFACTORY TO EACH OF
THEM.


 



    	 	 A-6-1 	 



     


    




 


[EACH PURCHASER OF THIS SECURITY IS HEREBY NOTIFIED THAT THE
SELLER OF THIS SECURITY MAY BE RELYING ON THE EXEMPTION FROM THE PROVISIONS OF SECTION 5 OF THE SECURITIES ACT PROVIDED BY
RULE 144A THEREUNDER.](2)


 


[BY ITS ACQUISITION HEREOF, THE HOLDER HEREOF REPRESENTS THAT
IT IS NOT A U.S. PERSON NOR IS IT PURCHASING FOR THE ACCOUNT OF A U.S. PERSON AND IS ACQUIRING THIS SECURITY IN AN OFFSHORE TRANSACTION
IN ACCORDANCE WITH REGULATION S UNDER THE SECURITIES ACT.](3)


 


[IN CONNECTION WITH ANY TRANSFER, THE HOLDER WILL DELIVER TO
THE REGISTRAR AND TRANSFER AGENT SUCH CERTIFICATES AND OTHER INFORMATION AS SUCH TRANSFER AGENT MAY REASONABLY REQUIRE TO CONFIRM
THAT THE TRANSFER COMPLIES WITH THE FOREGOING RESTRICTIONS.](4)


 


(1) Applies to Global Notes only


 


(2) Applies to Rule 144A Notes only


 


(3) Applies to Regulation S Notes only


 


(4) Applies to Notes in definitive form
only


 






    	 	 A-6-2 	 



     


    

 


ABBVIE INC.


 


2.600% Senior Notes due 2024


 


	No. [●]	$[●]


 


CUSIP No: [●]


 


ISIN No: [●]


 


ABBVIE INC., a corporation duly organized
and existing under the laws of Delaware (herein called the “Company,” which term includes any successor Person
under the Indenture and Supplemental Indenture hereinafter referred to), for value received, hereby promises to pay to Cede &
Co., as nominee for The Depository Trust Company, or registered assigns, the principal sum of [●] Dollars ($[●]), or
such other principal sum as may be indicated on the Schedule of Exchanges attached hereto, on November 21, 2024, and to pay interest
thereon from November 21, 2019 or from the most recent Interest Payment Date to which interest has been paid or duly provided for,
semi-annually in arrears on May 21 and November 21 of each year, commencing on May 21, 2020, at the rate of 2.600% per annum, until
the principal hereof is paid or made available for payment. The interest so payable, and punctually paid or duly provided for,
on any Interest Payment Date will, as provided in such Indenture, be paid to the Person in whose name this Security (or one or
more Predecessor Securities) is registered at the close of business on the Regular Record Date for such interest, which shall be
the date that is 15 calendar days prior to the relevant Interest Payment Date (whether or not a Business Day). Any such interest
not so punctually paid or duly provided for will forthwith cease to be payable to the Holder on such Regular Record Date and may
either be paid to the Person in whose name this Security (or one or more Predecessor Securities) is registered at the close of
business on a Special Record Date for the payment of such Defaulted Interest to be fixed by the Trustee, notice whereof shall be
given to Holders of Securities of this series not less than 10 days prior to such Special Record Date, or be paid at any time in
any other lawful manner not inconsistent with the requirements of any securities exchange on which the Securities of this series
may be listed, and upon such notice as may be required by such exchange, all as more fully provided in said Indenture.


 


Payment of the principal of (and premium,
if any) and any such interest on this Security will be made at the office or agency of the Company maintained for that purpose
in St. Paul, Minnesota, in such coin or currency of the United States of America as at the time of payment is legal tender for
payment of public and private debts; provided, however, that at the option of the Company payment of interest may be made by (1) check
mailed to the address of the Person entitled thereto as such address shall appear in the Security Register or (2) wire transfer
as directed by the Holder, in immediately available funds to an account maintained by the Depository or its nominee with respect
to a Global Note, and to the Holder or its nominee with respect to a Definitive Note; provided further that in the case of a Definitive
Note (1) the Holder thereof shall have provided written wiring instructions to the Trustee on or before the related Regular
Record Date and (2) if appropriate instructions for any such wire transfer are not received by the related Regular Record
Date, then such payment shall be made by check mailed to the address of the Holder specified in the Security Register.


 






    	 	 A-6-3 	 



     


    

 


Reference is hereby made to the further
provisions of this Security set forth on the reverse hereof, which further provisions shall for all purposes have the same effect
as if set forth at this place.


 


Unless the certificate of authentication
hereon has been executed by the Trustee referred to herein by manual signature, this Security shall not be entitled to any benefit
under the Indenture or be valid or obligatory for any purpose.


 



    	 	 A-6-4 	 



     


    




 


IN WITNESS WHEREOF, the Company has caused
this instrument to be duly executed.


 


Dated: November 21, 2019


 


 


	 	ABBVIE INC.
	 	 	 
	 	By:	
	 	 	Name:
	 	 	Title:




 






    	 	 A-6-5 	 



     


    

 


TRUSTEE’S CERTIFICATE OF AUTHENTICATION


 


This is one of the Securities of the series
designated therein referred to in the within-mentioned Indenture.


 


Dated: November 21, 2019


 


 


	 	U.S. BANK NATIONAL ASSOCIATION,
	 	as Trustee
	 	 
	 	By:
	 	Authorized Signatory




 



    	 	 A-6-6 	 



     


    




 


[FORM OF REVERSE OF SECURITY]


 


This Security is one of a duly authorized
issue of securities of the Company (herein called the “Securities”), issued and to be issued in one or more
series under an Indenture, dated as of November 8, 2012, as it may be supplemented or amended from time to time (herein called
the “Indenture”), between the Company and U.S. Bank National Association, as Trustee (herein called the “Trustee,”
which term includes any successor trustee under the Indenture), and Supplemental Indenture No. 7, dated as of November 21,
2019 (herein called the “Supplemental Indenture”), between the Company and the Trustee, to which Indenture,
Supplemental Indenture and all indentures supplemental thereto reference is hereby made for a statement of the respective rights,
limitations of rights, duties and immunities thereunder of the Company, the Trustee and the Holders of the Securities of this series
and of the terms upon which the Securities of this series are, and are to be, authenticated and delivered. This Security is one
of the series designated on the face hereof, in an initial aggregate principal amount of $[●].


 


Optional Redemption 


 


At any time prior to the Par Call Date (as
defined below), the Company may redeem some or all of the Securities of this series at its option, in each case at a redemption
price equal to the greater of: (i) 100% of the principal amount of the Securities of this series to be redeemed; and (ii) the sum
of the present values of the remaining scheduled payments (through the Par Call Date assuming for such purpose that such Securities
matured on the Par Call Date) of principal and interest on the Securities of this series to be redeemed (exclusive of interest
accrued to the Redemption Date) discounted to the Redemption Date on a semiannual basis (assuming a 360-day year consisting of
twelve 30-day months) at the then current Treasury Rate plus 15 basis points.


 


The Company will pay accrued and unpaid
interest on the principal amount of the Securities of this series being redeemed to, but excluding, the Redemption Date.


 


In addition, at any time on or after the
Par Call Date, the Company may redeem some or all of the Securities of this series at its option at a redemption price equal to
100% of the principal amount of the Securities of this series to be redeemed, plus accrued and unpaid interest on the principal
amount of Securities of this series being redeemed to, but excluding, the Redemption Date.


 


If the Company has given notice as provided
in the Indenture and funds for the redemption of any Securities of this series called for redemption have been made available on
the Redemption Date in accordance with the Indenture, such Securities will cease to bear interest on the date fixed for redemption.
Thereafter, the only right of the Holders of such Securities will be to receive payment of the redemption price.


 


The Company will give notice of any
optional redemption, electronically or by mail, to Holders at their addresses, as shown in the Security Register for such
Securities, or as otherwise in accordance with the applicable procedures of DTC, not more than 60 nor less than 15 days prior
to the date fixed for redemption. The notice of redemption will specify, among other items, the Redemption Date, redemption
price, the principal amount of the Securities of this series to be redeemed and the place or places that payment will be made
upon surrender of the Securities of this series to be redeemed. Any redemption or notice of redemption may, at the
Company’s discretion, be subject to one or more conditions precedent, and, at the Company’s discretion, the
redemption date may be delayed until such time as any or all such conditions shall be satisfied. The Company shall provide
written notice to the Trustee prior to the close of business two Business Days prior to the redemption date if any such
redemption has been rescinded or delayed, and upon receipt the Trustee shall provide such notice to each holder of the
Securities in the same manner in which the notice of redemption was given.


 






    	 	 A-6-7 	 



     


    

 


The Company will notify the Trustee at least
30 days prior to the Redemption Date fixed by the Company (or such shorter period as is satisfactory to the Trustee) of the aggregate
principal amount of the Securities of this series to be redeemed and their Redemption Date. If less than all of the Securities
of this series are to be redeemed at any time, the Trustee shall select, not more than 30 days prior to the Redemption Date, which
Securities or the portion thereof, that are to be redeemed from the outstanding Securities of this series not previously redeemed
by random lot.


 


“Comparable Treasury Issue”
means the United States Treasury security selected by the Independent Investment Banker as having a maturity comparable to the
remaining term (assuming, for this purpose, that the Securities matured on the Par Call Date) (“Remaining Life”) of
the Securities of this series to be redeemed that would be utilized, at the time of selection and in accordance with customary
financial practice, in pricing new issues of corporate debt securities of comparable maturity to the Remaining Life of such Securities
(assuming, for this purpose, that the Securities matured on the Par Call Date).


 


“Comparable Treasury Price”
means, with respect to any Redemption Date, (1) if the Company obtains four or more Reference Treasury Dealer Quotations for
such Redemption Date, the average of such Reference Treasury Dealer Quotations, after excluding the highest and lowest Reference
Treasury Dealer Quotations, or (2) if the Company obtains fewer than four such Reference Treasury Dealer Quotations, the average
of all such quotations.


 


“Independent Investment Banker”
means one of the Reference Treasury Dealers that the Company appoints to act as the Independent Investment Banker from time to
time.


 


“Business Day” means
any calendar day that is not a Saturday, Sunday or legal holiday in New York, New York and on which commercial banks are open for
business in New York, New York.


 


“Par Call Date” means
October 21, 2024 (one month prior to the maturity date of the Securities of this series).


 


“Primary Treasury Dealer”
means a primary United States government securities dealer in the United States of America.


 


“Reference Treasury
Dealer” means (i) each of Morgan Stanley & Co. LLC, BofA Securities, Inc., Barclays Capital Inc. and
any of their respective successors; provided, however, that if any of them ceases to be a Primary Treasury Dealer, the
Company will substitute therefor another Primary Treasury Dealer and (ii) any other Primary Treasury Dealers the Company
selects.


 






    	 	 A-6-8 	 



     


    

 


“Reference Treasury Dealer Quotations”
means, with respect to each Reference Treasury Dealer and any Redemption Date, the average, as determined by the Company, of the
bid and asked prices for the Comparable Treasury Issue (expressed in each case as a percentage of its principal amount) quoted
in writing to the Company by such Reference Treasury Dealer at 3:30 p.m., New York City time, on the third Business Day preceding
such Redemption Date.


 


“Treasury Rate” means,
with respect to any Redemption Date, (1) the rate per annum equal to the yield, under the heading which represents the average
for the immediately preceding week, appearing in the most recently published statistical release designated “H.15(519)”
or any successor publication which is published weekly by the Board of Governors of the Federal Reserve System and which establishes
yields on actively traded United States Treasury securities adjusted to constant maturity under the caption “Treasury Constant
Maturities” for the maturity corresponding to the Comparable Treasury Issue; provided that, if no maturity is within three
months before or after the Remaining Life of the Securities of this series to be redeemed, yields for the two published maturities
most closely corresponding to the Comparable Treasury Issue shall be determined and the Treasury Rate shall be interpolated or
extrapolated from those yields on a straight line basis, rounding to the nearest month; or (2) if such release (or any successor
release) is not published during the week preceding the calculation date or does not contain such yields, the rate per year equal
to the semiannual equivalent yield to maturity of the Comparable Treasury Issue, calculated using a price for the Comparable Treasury
Issue (expressed as a percentage of its principal amount) equal to the Comparable Treasury Price for such Redemption Date. The
Treasury Rate shall be calculated on the third Business Day preceding the Redemption Date.


 


Special Mandatory Redemption 


 


If (i)
the consummation of the Acquisition (as defined below) does not occur on or before January 30, 2021 or (ii) the Company notifies
the Trustee that the Company will not pursue the consummation of the Acquisition (each of (i) and (ii), a “Special Mandatory
Redemption Trigger”), the Company will be required to redeem the Securities of this series then outstanding (such redemption,
the “Special Mandatory Redemption”) at a redemption price equal to 101% of the principal amount of such Securities
plus accrued and unpaid interest, if any, to, but not including, the Special Mandatory Redemption Date (the “Special Mandatory
Redemption Price”). The “Acquisition” means the acquisition by the Company of Allergan plc and its
subsidiaries pursuant to the definitive transaction agreement, dated as of June 25, 2019, by and among the Company, Venice Subsidiary
LLC, a Delaware limited liability company and a direct wholly owned subsidiary of the Company, and Allergan plc, as amended from
time to time.


 


In
the event that the Company becomes obligated to redeem the Securities of this series pursuant to the Special Mandatory
Redemption, the Company will promptly, and in any event not more than five Business Days after the date on which a Special
Mandatory Redemption Trigger occurred, deliver notice to the Trustee of the Special Mandatory Redemption and the date upon
which the Securities of this series will be redeemed (the “Special Mandatory Redemption Date,” which date
shall be no later than the third Business Day following the date of such notice) together with a notice of Special Mandatory
Redemption for the Trustee to deliver to each registered holder of the Securities of this series to be redeemed. The Trustee
will then promptly mail, or electronically deliver, according to the procedures of DTC, such notice of Special Mandatory
Redemption to each registered holder of the Securities of this series to be redeemed. Unless the Company defaults in payment
of the Special Mandatory Redemption Price, on and after such Special Mandatory Redemption Date, interest will cease to accrue
on the Securities of this series to be redeemed.


 






    	 	 A-6-9 	 



     


    

 


Failure to comply in any material respect
with any obligations in the provisions described under this caption “Special Mandatory Redemption” shall constitute
an “Event of Default” under Section 5.1(7) of the Indenture.


 


Notwithstanding the foregoing, installments
of interest on the Securities of this series that are due and payable on Interest Payment Dates falling on or prior to the Special
Mandatory Redemption Date will be payable on such Interest Payment Dates to the Holder as of the close of business on the relevant
Record Dates in accordance with the Securities of this series and the Indenture.


 


For the avoidance of doubt, Article Eleven
of the Indenture shall not apply to the Special Mandatory Redemption.


 


Sinking Fund 


 


The Securities of this series do not provide
for a sinking fund.


 


Default 


 


If an Event of Default with respect to Securities
of this series shall occur and be continuing, the principal of the Securities of this series may be declared due and payable in
the manner and with the effect provided in the Indenture.


 


Miscellaneous


 


The Indenture contains provisions for defeasance
at any time of the entire indebtedness of this Security or certain restrictive covenants and Events of Default with respect to
this Security, in each case upon compliance with certain conditions set forth therein. Sections 13.2 and 13.3 of the Indenture
apply to the Securities of this series.


 


The Indenture permits, with certain
exceptions as therein provided, the amendment thereof and the modification of the rights and obligations of the Company and
the rights of the Holders of the Securities of each series to be affected under the Indenture at any time by the Company and
the Trustee with the consent of the Holders of not less than a majority in principal amount of the Securities at the time
Outstanding of each series to be affected. The Indenture also contains provisions permitting the Holders of specified
percentages in principal amount of the Securities at the time Outstanding of any series, on behalf of the Holders of all
Securities of such series, to waive compliance by the Company with certain provisions of the Indenture and certain past
defaults under the Indenture and their consequences. Any such consent or waiver by the Holder of this Security shall be
conclusive and binding upon such Holder and upon all future Holders of this Security and of any Security issued upon the
registration of transfer hereof or in exchange herefor or in lieu hereof, whether or not notation of such consent or waiver
is made upon this Security.


 






    	 	 A-6-10 	 



     


    

 


No reference herein to the Indenture or
Supplemental Indenture and no provision of this Security or of the Indenture or Supplemental Indenture shall alter or impair the
obligation of the Company, which is absolute and unconditional, to pay the principal of and any premium and interest on this Security
at the times, place and rate, and in the coin or currency, herein prescribed.


 


As provided in the Indenture and subject
to certain limitations therein set forth, the transfer of this Security is registerable in the Security Register, upon surrender
of this Security for registration of transfer at the office or agency of the Company in any place where the principal of and any
premium and interest on this Security are payable, duly endorsed by, or accompanied by a written instrument of transfer in form
satisfactory to the Company and the Security Registrar duly executed by, the Holder hereof or his attorney duly authorized in writing,
and thereupon one or more new Securities of this series and of like tenor, of authorized denominations and for the same aggregate
principal amount, will be issued to the designated transferee or transferees.


 


The Securities of this series are issuable
only in registered form without coupons in denominations of $2,000 and any integral multiple of $1,000 in excess thereof. As provided
in the Indenture and subject to certain limitations therein set forth, Securities of this series are exchangeable for a like aggregate
principal amount of Securities of this series and of like tenor of a different authorized denomination, as requested by the Holder
surrendering the same.


 


No service charge shall be made for any
registration of transfer or exchange of the Notes, but the Company or the Security Registrar may require payment of a sum sufficient
to cover any transfer tax, assessments, or similar governmental charge payable in connection therewith (other than any such transfer
taxes, assessments or similar governmental charge payable upon exchange or transfer pursuant to Sections 9.6 or 11.7 of the Indenture).


 


Prior to due presentment of this Security
for registration of transfer, the Company, the Trustee and any agent of the Company or the Trustee will treat the Person in whose
name this Security is registered as the owner hereof for the purpose of receiving payments and for all other purposes, whether
or not this Security be overdue, and neither the Company, the Trustee nor any such agent shall be affected by notice to the contrary.


 


All terms used in this Security which are
defined in the Indenture and Supplemental Indenture shall have the meanings assigned to them in the Indenture and Supplemental
Indenture.


 


THIS SECURITY SHALL BE GOVERNED BY AND CONSTRUED
IN ACCORDANCE WITH THE LAWS OF THE STATE OF NEW YORK.


 






    	 	 A-6-11 	 



     


    

  


This Security is a Book-Entry
Security within the meaning of the Indenture hereinafter referred to and is registered in the name of a Depository or a
nominee of a Depository. This Security is exchangeable for Securities registered in the name of a person other than the
Depository or its nominee only in the limited circumstances described in the Indenture and may not be transferred except as a
whole by the Depository to a nominee of the Depository or by a nominee of the Depository to the Depository or another nominee
of the Depository.


 


*                                        
*                                        
*



 






    	 	 A-6-12 	 



     


    

 


SCHEDULE OF EXCHANGES


 


The following exchanges, redemptions or
purchases of a part of this Book-Entry Security have been made:


 


	Date of

Exchange/

Redemption/

Repurchase	Amount of

decrease in

Principal Amount

of this Book-

Entry

Security	Amount of

increase in

Principal Amount

of this Book-

Entry Security	Principal Amount

of this Book-

Entry

Security following

such decrease (or

increase)	Signature of

authorized

signatory of

Trustee
	 	 	 	 	 
	 	 	 	 	 
	 	 	 	 	 



 






    	 	 A-6-13 	 



     


    

 


ASSIGNMENT FORM


 


To assign this Security, fill in the form below:


 


I or we assign and transfer this Security to


 


	 
	(Print or type assignee’s name, address and zip code)





	 
	(Insert assignee’s soc. sec. or tax I.D. No.)


and irrevocably appoint                               
as agent to transfer this Security on the books of the Company. The agent may substitute another to act for him.


 


 


	Date:	 
	 	 
	Your Signature*:	 
	 	 
	By:	 
	 	 
	Name:	 
	 	 
	Title:	 




 


Sign exactly as your name appears on the other side of this
Security.


 


 


*Signature Guaranteed:


 


*NOTICE: The signature to this assignment must correspond with
the name as it appears upon the face of the within Note in every particular, without alteration, enlargement or any change whatever.
Such signature must be guaranteed by an “eligible guarantor institution” meeting the requirements of the Security Registrar,
which requirements include membership or participation in Security Transfer Agents Medallion Program (“STAMP”) or such
other “signature guarantee program” as may be determined by the Security Registrar in addition to, or in substitution
for, STAMP, all in accordance with the Securities Exchange Act of 1934, as amended.


 






    	 	 A-6-14 	 



     


    

 


FORM OF TRANSFER CERTIFICATE


 


In connection with any transfer of any of
the Securities evidenced by this certificate occurring prior to the expiration of the period referred to in Rule 144 under
the Securities Act (“Rule 144”) after the later of the date of original issuance of such Notes and the last date,
if any, on which such Notes were owned by the Company or any Affiliate (as such term is defined in Rule 144) of the Company,
the undersigned confirms that such Securities are being transferred in accordance with its terms:


 


CHECK
ONE BOX BELOW


 


		(1)	 ̈to the Company; or



 


		(2)	 ̈pursuant to an effective registration statement under the Securities Act; or



 


		(3)	 ̈inside the United States to a person reasonably believed to be a “qualified institutional buyer” (as
defined in Rule 144A under the Securities Act) that purchases for its own account or for the account of a qualified institutional
buyer to whom notice is given that such transfer is being made in reliance on Rule 144A, in each case pursuant to and in compliance
with Rule 144A under the Securities Act; or



 


		(4)	 ̈in an offshore transaction in compliance with Rule 903 or Rule 904 of Regulation S under the Securities Act; or



 


		(5)	 ̈pursuant to the exemption from registration provided
by Rule 144 under the Securities Act or any other available exemption from the registration requirement of the Securities Act.



 


Unless one of the boxes is checked,
the Trustee shall refuse to register any of the Securities evidenced by this certificate in the name of any person other than the
registered holder thereof; provided, however, that if box (5) is checked, the Trustee shall be entitled to require, prior
to registering any such transfer of the Securities, such legal opinions, certifications and other information as the Company has
reasonably requested to confirm that such transfer is being made pursuant to an exemption from, or in a transaction not subject
to, the registration requirements of the Securities Act.


 


	 	 
	 	Signature




 






    	 	 A-6-15 	 



     


    

 


TO BE COMPLETED
BY PURCHASER IF (3) ABOVE IS CHECKED.


 


The undersigned represents and warrants that it is purchasing
this Security for its own account or an account with respect to which it exercises sole investment discretion and that it and any
such account is a “qualified institutional buyer” within the meaning of Rule 144A under the Securities Act, and is
aware that the sale to it is being made in reliance on Rule 144A and acknowledges that it has received such information regarding
the Company as the undersigned has requested pursuant to Rule 144A or has determined not to request such information and that it
is aware that the transferor is relying upon the undersigned’s foregoing representations in order to claim the exemption
from registration provided by Rule 144A.


 


	Dated:	 	 	Notice:
                                         To be executed by an executive officer



 






    	 	 A-6-16 	 



     


    

 


FORM OF EXCHANGE CERTIFICATE


 


AbbVie Inc.


1 North Waukegan Road


North Chicago, Illinois 60064


 


U.S. Bank National Association


190 South LaSalle Street, 10th Floor


Chicago, IL 60603


Attention: Corporate Trust Services


 


Re: 2.600% Senior Notes due
2024


 


Reference is hereby made to the Indenture,
dated as of November 8, 2012 (the “Base Indenture”), as supplemented by the First Supplemental Indenture, dated as
of November 8, 2012, the Second Supplemental Indenture, dated as of May 14, 2015, the Third Supplemental Indenture, dated as of
May 12, 2016, the Fourth Supplemental Indenture, dated as of November 17, 2016, the Fifth Supplemental Indenture, dated as of September
18, 2018, the Sixth Supplemental Indenture, dated as of September 26, 2019 and the Seventh Supplemental Indenture, dated as of
November 21, 2019 (as so supplemented, the “Indenture”), between AbbVie Inc. (the “Company”) and U.S. Bank
National Association, a national banking association as trustee. Capitalized terms used but not defined herein shall have the meanings
given to them in the Indenture.


 


                             (the
 “Owner”) owns and proposes to exchange the Security[ies] or interest in such Security[ies] specified herein, in the
principal amount of $                             in
such Security[ies] or interests (the “Exchange”). In connection with the Exchange, the Owner hereby certifies that
in connection with the Exchange of the Owner’s Regulation S Global Note for a beneficial interest in the Rule 144A Global
Note, with an equal principal amount, the Security[ies] or interest in such Security[ies] specified herein [is][are] being transferred
to a Person (A) who the transferor reasonably believes to be a QIB, (B) purchasing for its own account or the account of a QIB
in a transaction meeting the requirements of Rule 144A, and (C) in accordance with all applicable securities laws of the States
of the United States and other jurisdictions.


 


This certificate and the statements contained
herein are made for your benefit and the benefit of the Company and are dated ____________.


 


	 	 	 	[Insert Name of Transferor]
	 	 	 	 
	 	 	 	By:	 
	 	 	 	 	Name:
	 	 	 	 	Title:
	 	 	 	 
	Dated:	 	 	




 






    	 	 A-6-17 	 



     


    

 


 





EXHIBIT A7


 


(FORM OF FACE OF INITIAL NOTE)


 


[THIS SECURITY IS A GLOBAL SECURITY WITHIN THE MEANING OF THE
INDENTURE HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME OF A DEPOSITARY OR A NOMINEE OF A DEPOSITARY. UNLESS AND UNTIL
IT IS EXCHANGED IN WHOLE OR IN PART FOR SECURITIES IN DEFINITIVE FORM IN ACCORDANCE WITH THE PROVISIONS OF THE INDENTURE
AND THE TERMS OF THE SECURITIES, TRANSFERS OF THIS GLOBAL SECURITY SHALL BE LIMITED TO TRANSFERS IN WHOLE, BUT NOT IN PART, TO
THE DEPOSITORY TRUST COMPANY, A NEW YORK CORPORATION (“DTC”), TO NOMINEES OF DTC OR TO A SUCCESSOR THEREOF OR SUCH
SUCCESSOR’S NOMINEE AND TRANSFERS OF PORTIONS OF THIS GLOBAL SECURITY SHALL BE LIMITED TO TRANSFERS MADE IN ACCORDANCE WITH
THE RESTRICTIONS SET FORTH IN THE INDENTURE REFERRED TO ON THE REVERSE HEREOF.


 


UNLESS THIS CERTIFICATE IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE
OF DTC, TO ABBVIE INC., OR ITS AGENT FOR REGISTRATION OF TRANSFER, EXCHANGE OR PAYMENT, AND ANY CERTIFICATE ISSUED IS REGISTERED
IN THE NAME OF CEDE & CO. OR IN SUCH OTHER NAME AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC (AND ANY PAYMENT
IS MADE TO CEDE & CO. OR TO SUCH OTHER ENTITY AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC), ANY TRANSFER,
PLEDGE OR OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL INASMUCH AS THE REGISTERED OWNER HEREOF, CEDE &
CO., HAS AN INTEREST HEREIN.](1)


 


THIS SECURITY HAS NOT BEEN REGISTERED UNDER THE SECURITIES ACT
OF 1933, AS AMENDED (THE “SECURITIES ACT”), OR THE SECURITIES LAWS OF ANY STATE OR OTHER JURISDICTION.


 






    A-7-1


     


    

 





NEITHER THIS SECURITY NOR ANY INTEREST OR PARTICIPATION HEREIN
MAY BE REOFFERED, SOLD, ASSIGNED, TRANSFERRED, PLEDGED, ENCUMBERED OR OTHERWISE DISPOSED OF IN THE ABSENCE OF SUCH REGISTRATION
OR UNLESS SUCH TRANSACTION IS EXEMPT FROM, OR NOT SUBJECT TO, SUCH REGISTRATION. THE HOLDER OF THIS SECURITY, BY ITS ACCEPTANCE
HEREOF, AGREES ON ITS OWN BEHALF AND ON BEHALF OF ANY INVESTOR ACCOUNT FOR WHICH IT HAS PURCHASED SECURITIES, TO OFFER, SELL OR
OTHERWISE TRANSFER SUCH SECURITY, PRIOR TO THE DATE (THE “RESALE RESTRICTION TERMINATION DATE”) THAT IS [IN THE CASE
OF RULE 144A NOTES: ONE YEAR] [IN THE CASE OF REGULATION S NOTES: 40 DAYS] AFTER THE LATER OF THE ISSUE DATE HEREOF OR ANY OTHER
ISSUE DATE IN RESPECT OF A FURTHER ISSUANCE OF SECURITIES OF THE SAME SERIES AND THE LAST DATE ON WHICH ABBVIE INC. OR ANY AFFILIATE
OF ABBVIE INC. WAS THE OWNER OF THIS SECURITY (OR ANY PREDECESSOR OF SUCH SECURITY), ONLY (A) TO ABBVIE INC. OR ANY SUBSIDIARY
THEREOF, (B) PURSUANT TO A REGISTRATION STATEMENT THAT HAS BEEN DECLARED EFFECTIVE UNDER THE SECURITIES ACT, (C) FOR
SO LONG AS THE SECURITIES ARE ELIGIBLE FOR RESALE PURSUANT TO RULE 144A UNDER THE SECURITIES ACT (“RULE 144A”),
TO A PERSON IT REASONABLY BELIEVES IS A ‘‘QUALIFIED INSTITUTIONAL BUYER’’ AS DEFINED IN RULE 144A
THAT PURCHASES FOR ITS OWN ACCOUNT OR FOR THE ACCOUNT OF A QUALIFIED INSTITUTIONAL BUYER TO WHOM NOTICE IS GIVEN THAT THE TRANSFER
IS BEING MADE IN RELIANCE ON RULE 144A IN A TRANSACTION MEETING THE REQUIREMENTS OF RULE 144A, (D) PURSUANT TO OFFERS
AND SALES TO NON-U.S. PERSONS THAT OCCUR OUTSIDE THE UNITED STATES WITHIN THE MEANING OF REGULATION S UNDER THE SECURITIES
ACT, (E) TO AN INSTITUTIONAL “ACCREDITED INVESTOR” WITHIN THE MEANING OF RULE 501(a)(1), (2), (3) OR
(7) UNDER THE SECURITIES ACT THAT IS NOT A QUALIFIED INSTITUTIONAL BUYER AND THAT IS PURCHASING FOR ITS OWN ACCOUNT OR FOR
THE ACCOUNT OF ANOTHER INSTITUTIONAL ACCREDITED INVESTOR, IN EACH CASE IN A MINIMUM PRINCIPAL AMOUNT OF THE SECURITIES OF
$250,000, FOR INVESTMENT PURPOSES AND NOT WITH A VIEW TO OR FOR OFFER OR SALE IN CONNECTION WITH ANY DISTRIBUTION IN VIOLATION
OF THE SECURITIES ACT OR (F) PURSUANT TO ANOTHER AVAILABLE EXEMPTION FROM THE REGISTRATION REQUIREMENTS OF THE SECURITIES
ACT, SUBJECT TO ABBVIE INC.’S AND THE TRUSTEE’S RIGHT PRIOR TO ANY SUCH OFFER, SALE OR TRANSFER PURSUANT TO CLAUSES (D),
(E) OR (F) TO REQUIRE THE DELIVERY OF AN OPINION OF COUNSEL, CERTIFICATION AND/OR OTHER INFORMATION SATISFACTORY TO EACH
OF THEM.


 


[EACH PURCHASER OF THIS SECURITY IS HEREBY NOTIFIED THAT THE
SELLER OF THIS SECURITY MAY BE RELYING ON THE EXEMPTION FROM THE PROVISIONS OF SECTION 5 OF THE SECURITIES ACT PROVIDED
BY RULE 144A THEREUNDER.](2)


 


[BY ITS ACQUISITION HEREOF, THE HOLDER HEREOF REPRESENTS THAT
IT IS NOT A U.S. PERSON NOR IS IT PURCHASING FOR THE ACCOUNT OF A U.S. PERSON AND IS ACQUIRING THIS SECURITY IN AN OFFSHORE TRANSACTION
IN ACCORDANCE WITH REGULATION S UNDER THE SECURITIES ACT.](3)


 


[IN CONNECTION WITH ANY TRANSFER, THE HOLDER WILL DELIVER TO
THE REGISTRAR AND TRANSFER AGENT SUCH CERTIFICATES AND OTHER INFORMATION AS SUCH TRANSFER AGENT MAY REASONABLY REQUIRE TO
CONFIRM THAT THE TRANSFER COMPLIES WITH THE FOREGOING RESTRICTIONS.](4)


  


 








(1) Applies to Global Notes only


 


(2) Applies to Rule 144A Notes only


 


(3) Applies to Regulation S Notes only


 


(4) Applies to Notes in definitive form only


 






    A-7-2


     


    

 


ABBVIE INC.


 


2.950% Senior Notes due 2026


 


	No. [●]	$[●]


 


CUSIP No: [●]


 


ISIN No: [●]


 


ABBVIE INC., a corporation duly organized
and existing under the laws of Delaware (herein called the “Company,” which term includes any successor Person
under the Indenture and Supplemental Indenture hereinafter referred to), for value received, hereby promises to pay to Cede &
Co., as nominee for The Depository Trust Company, or registered assigns, the principal sum of [●] Dollars ($[●]), or
such other principal sum as may be indicated on the Schedule of Exchanges attached hereto, on November 21, 2026, and to pay
interest thereon from November 21, 2019 or from the most recent Interest Payment Date to which interest has been paid or duly
provided for, semi-annually in arrears on May 21 and November 21 of each year, commencing on May 21, 2020, at the
rate of 2.950% per annum, until the principal hereof is paid or made available for payment. The interest so payable, and punctually
paid or duly provided for, on any Interest Payment Date will, as provided in such Indenture, be paid to the Person in whose name
this Security (or one or more Predecessor Securities) is registered at the close of business on the Regular Record Date for such
interest, which shall be the date that is 15 calendar days prior to the relevant Interest Payment Date (whether or not a Business
Day). Any such interest not so punctually paid or duly provided for will forthwith cease to be payable to the Holder on such Regular
Record Date and may either be paid to the Person in whose name this Security (or one or more Predecessor Securities) is registered
at the close of business on a Special Record Date for the payment of such Defaulted Interest to be fixed by the Trustee, notice
whereof shall be given to Holders of Securities of this series not less than 10 days prior to such Special Record Date, or be paid
at any time in any other lawful manner not inconsistent with the requirements of any securities exchange on which the Securities
of this series may be listed, and upon such notice as may be required by such exchange, all as more fully provided in said Indenture.


 


Payment of the principal of (and premium,
if any) and any such interest on this Security will be made at the office or agency of the Company maintained for that purpose
in St. Paul, Minnesota, in such coin or currency of the United States of America as at the time of payment is legal tender for
payment of public and private debts; provided, however, that at the option of the Company payment of interest may be made by (1) check
mailed to the address of the Person entitled thereto as such address shall appear in the Security Register or (2) wire transfer
as directed by the Holder, in immediately available funds to an account maintained by the Depository or its nominee with respect
to a Global Note, and to the Holder or its nominee with respect to a Definitive Note; provided further that in the case of a Definitive
Note (1) the Holder thereof shall have provided written wiring instructions to the Trustee on or before the related Regular
Record Date and (2) if appropriate instructions for any such wire transfer are not received by the related Regular Record
Date, then such payment shall be made by check mailed to the address of the Holder specified in the Security Register.








 


Reference is hereby made to the further
provisions of this Security set forth on the reverse hereof, which further provisions shall for all purposes have the same effect
as if set forth at this place.


 


Unless the certificate of authentication
hereon has been executed by the Trustee referred to herein by manual signature, this Security shall not be entitled to any benefit
under the Indenture or be valid or obligatory for any purpose.


 






    A-7-3


     


    

 


IN WITNESS WHEREOF, the Company has caused
this instrument to be duly executed.


 


Dated: November 21, 2019


 


	 	ABBVIE INC.
	 	 
	 	By:
	 	 	Name:
	 	 	Title:


 






    A-7-4


     


    

 


TRUSTEE’S CERTIFICATE OF AUTHENTICATION


 


This is one of the Securities of the series
designated therein referred to in the within-mentioned Indenture.


 


Dated: November 21, 2019


 


	 	U.S. BANK NATIONAL ASSOCIATION,
	 	 	as Trustee
	 	 
	 	By:
	 	 
	 	 	Authorized Signatory


 






    A-7-5


     


    

 


[FORM OF REVERSE OF SECURITY]


 


This Security is one of a duly authorized
issue of securities of the Company (herein called the “Securities”), issued and to be issued in one or more
series under an Indenture, dated as of November 8, 2012, as it may be supplemented or amended from time to time (herein called
the “Indenture”), between the Company and U.S. Bank National Association, as Trustee (herein called the “Trustee,”
which term includes any successor trustee under the Indenture), and Supplemental Indenture No. 7, dated as of November 21,
2019 (herein called the “Supplemental Indenture”), between the Company and the Trustee, to which Indenture,
Supplemental Indenture and all indentures supplemental thereto reference is hereby made for a statement of the respective rights,
limitations of rights, duties and immunities thereunder of the Company, the Trustee and the Holders of the Securities of this series
and of the terms upon which the Securities of this series are, and are to be, authenticated and delivered. This Security is one
of the series designated on the face hereof, in an initial aggregate principal amount of $[●].


 


Optional Redemption


 


At any time prior to the Par Call Date (as
defined below), the Company may redeem some or all of the Securities of this series at its option, in each case at a redemption
price equal to the greater of: (i) 100% of the principal amount of the Securities of this series to be redeemed; and (ii) the
sum of the present values of the remaining scheduled payments (through the Par Call Date assuming for such purpose that such Securities
matured on the Par Call Date) of principal and interest on the Securities of this series to be redeemed (exclusive of interest
accrued to the Redemption Date) discounted to the Redemption Date on a semiannual basis (assuming a 360-day year consisting of
twelve 30-day months) at the then current Treasury Rate plus 20 basis points.


 


The Company will pay accrued and unpaid
interest on the principal amount of the Securities of this series being redeemed to, but excluding, the Redemption Date.


 


In addition, at any time on or after the
Par Call Date, the Company may redeem some or all of the Securities of this series at its option at a redemption price equal to
100% of the principal amount of the Securities of this series to be redeemed, plus accrued and unpaid interest on the principal
amount of Securities of this series being redeemed to, but excluding, the Redemption Date.


 


If the Company has given notice as provided
in the Indenture and funds for the redemption of any Securities of this series called for redemption have been made available on
the Redemption Date in accordance with the Indenture, such Securities will cease to bear interest on the date fixed for redemption.
Thereafter, the only right of the Holders of such Securities will be to receive payment of the redemption price.


 


The Company will give notice of any optional
redemption, electronically or by mail, to Holders at their addresses, as shown in the Security Register for such Securities, or
as otherwise in accordance with the applicable procedures of DTC, not more than 60 nor less than 15 days prior to the date fixed
for redemption. The notice of redemption will specify, among other items, the Redemption Date, redemption price, the principal
amount of the Securities of this series to be redeemed and the place or places that payment will be made upon surrender of the
Securities of this series to be redeemed. Any redemption or notice of redemption may, at the Company’s discretion, be subject
to one or more conditions precedent, and, at the Company’s discretion, the redemption date may be delayed until such time
as any or all such conditions shall be satisfied. The Company shall provide written notice to the Trustee prior to the close of
business two Business Days prior to the redemption date if any such redemption has been rescinded or delayed, and upon receipt
the Trustee shall provide such notice to each holder of the Securities in the same manner in which the notice of redemption was
given.


 






    A-7-6


     


    

 


The Company will notify the Trustee at least
30 days prior to the Redemption Date fixed by the Company (or such shorter period as is satisfactory to the Trustee) of the aggregate
principal amount of the Securities of this series to be redeemed and their Redemption Date. If less than all of the Securities
of this series are to be redeemed at any time, the Trustee shall select, not more than 30 days prior to the Redemption Date, which
Securities or the portion thereof, that are to be redeemed from the outstanding Securities of this series not previously redeemed
by random lot.


 


“Comparable Treasury Issue”
means the United States Treasury security selected by the Independent Investment Banker as having a maturity comparable to the
remaining term (assuming, for this purpose, that the Securities matured on the Par Call Date) (“Remaining Life”) of
the Securities of this series to be redeemed that would be utilized, at the time of selection and in accordance with customary
financial practice, in pricing new issues of corporate debt securities of comparable maturity to the Remaining Life of such Securities
(assuming, for this purpose, that the Securities matured on the Par Call Date).


 


“Comparable Treasury Price”
means, with respect to any Redemption Date, (1) if the Company obtains four or more Reference Treasury Dealer Quotations for
such Redemption Date, the average of such Reference Treasury Dealer Quotations, after excluding the highest and lowest Reference
Treasury Dealer Quotations, or (2) if the Company obtains fewer than four such Reference Treasury Dealer Quotations, the average
of all such quotations.


 


“Independent Investment Banker”
means one of the Reference Treasury Dealers that the Company appoints to act as the Independent Investment Banker from time to
time.


 


“Business Day” means
any calendar day that is not a Saturday, Sunday or legal holiday in New York, New York and on which commercial banks are open for
business in New York, New York.


 


“Par Call Date” means
September 21, 2026 (two months prior to the maturity date of the Securities of this series).


 


“Primary Treasury Dealer”
means a primary United States government securities dealer in the United States of America.


 


“Reference Treasury Dealer”
means (i) each of Morgan Stanley & Co. LLC, BofA Securities, Inc., Barclays Capital Inc. and any of their respective
successors; provided, however, that if any of them ceases to be a Primary Treasury Dealer, the Company will substitute therefor
another Primary Treasury Dealer and (ii) any other Primary Treasury Dealers the Company selects.


 






    A-7-7


     


    

 


“Reference Treasury Dealer Quotations”
means, with respect to each Reference Treasury Dealer and any Redemption Date, the average, as determined by the Company, of the
bid and asked prices for the Comparable Treasury Issue (expressed in each case as a percentage of its principal amount) quoted
in writing to the Company by such Reference Treasury Dealer at 3:30 p.m., New York City time, on the third Business Day preceding
such Redemption Date.


 


“Treasury Rate” means,
with respect to any Redemption Date, (1) the rate per annum equal to the yield, under the heading which represents the average
for the immediately preceding week, appearing in the most recently published statistical release designated “H.15(519)”
or any successor publication which is published weekly by the Board of Governors of the Federal Reserve System and which establishes
yields on actively traded United States Treasury securities adjusted to constant maturity under the caption “Treasury Constant
Maturities” for the maturity corresponding to the Comparable Treasury Issue; provided that, if no maturity is within three
months before or after the Remaining Life of the Securities of this series to be redeemed, yields for the two published maturities
most closely corresponding to the Comparable Treasury Issue shall be determined and the Treasury Rate shall be interpolated or
extrapolated from those yields on a straight line basis, rounding to the nearest month; or (2) if such release (or any successor
release) is not published during the week preceding the calculation date or does not contain such yields, the rate per year equal
to the semiannual equivalent yield to maturity of the Comparable Treasury Issue, calculated using a price for the Comparable Treasury
Issue (expressed as a percentage of its principal amount) equal to the Comparable Treasury Price for such Redemption Date. The
Treasury Rate shall be calculated on the third Business Day preceding the Redemption Date.


 


Special Mandatory Redemption


 


If (i) the consummation of the Acquisition
(as defined below) does not occur on or before January 30, 2021 or (ii) the Company notifies the Trustee that the Company
will not pursue the consummation of the Acquisition (each of (i) and (ii), a “Special Mandatory Redemption Trigger”),
the Company will be required to redeem the Securities of this series then outstanding (such redemption, the “Special Mandatory
Redemption”) at a redemption price equal to 101% of the principal amount of such Securities plus accrued and unpaid interest,
if any, to, but not including, the Special Mandatory Redemption Date (the “Special Mandatory Redemption Price”).
The “Acquisition” means the acquisition by the Company of Allergan plc and its subsidiaries pursuant to the
definitive transaction agreement, dated as of June 25, 2019, by and among the Company, Venice Subsidiary LLC, a Delaware limited
liability company and a direct wholly owned subsidiary of the Company, and Allergan plc, as amended from time to time.


 


In the event that the Company becomes obligated
to redeem the Securities of this series pursuant to the Special Mandatory Redemption, the Company will promptly, and in any event
not more than five Business Days after the date on which a Special Mandatory Redemption Trigger occurred, deliver notice to the
Trustee of the Special Mandatory Redemption and the date upon which the Securities of this series will be redeemed (the “Special
Mandatory Redemption Date,” which date shall be no later than the third Business Day following the date of such notice)
together with a notice of Special Mandatory Redemption for the Trustee to deliver to each registered holder of the Securities of
this series to be redeemed. The Trustee will then promptly mail, or electronically deliver, according to the procedures of DTC,
such notice of Special Mandatory Redemption to each registered holder of the Securities of this series to be redeemed. Unless the
Company defaults in payment of the Special Mandatory Redemption Price, on and after such Special Mandatory Redemption Date, interest
will cease to accrue on the Securities of this series to be redeemed.


 






    A-7-8


     


    

 


Failure to comply in any material respect
with any obligations in the provisions described under this caption “Special Mandatory Redemption” shall constitute
an “Event of Default” under Section 5.1(7) of the Indenture.


 


Notwithstanding the foregoing, installments
of interest on the Securities of this series that are due and payable on Interest Payment Dates falling on or prior to the Special
Mandatory Redemption Date will be payable on such Interest Payment Dates to the Holder as of the close of business on the relevant
Record Dates in accordance with the Securities of this series and the Indenture.


 


For the avoidance of doubt, Article Eleven
of the Indenture shall not apply to the Special Mandatory Redemption.


 


Sinking Fund


 


The Securities of this series do not provide
for a sinking fund.


 


Default


 


If an Event of Default with respect to Securities
of this series shall occur and be continuing, the principal of the Securities of this series may be declared due and payable in
the manner and with the effect provided in the Indenture.


 


Miscellaneous


 


The Indenture contains provisions for defeasance
at any time of the entire indebtedness of this Security or certain restrictive covenants and Events of Default with respect to
this Security, in each case upon compliance with certain conditions set forth therein. Sections 13.2 and 13.3 of the Indenture
apply to the Securities of this series.


 


The Indenture permits, with certain exceptions
as therein provided, the amendment thereof and the modification of the rights and obligations of the Company and the rights of
the Holders of the Securities of each series to be affected under the Indenture at any time by the Company and the Trustee with
the consent of the Holders of not less than a majority in principal amount of the Securities at the time Outstanding of each series
to be affected. The Indenture also contains provisions permitting the Holders of specified percentages in principal amount of the
Securities at the time Outstanding of any series, on behalf of the Holders of all Securities of such series, to waive compliance
by the Company with certain provisions of the Indenture and certain past defaults under the Indenture and their consequences. Any
such consent or waiver by the Holder of this Security shall be conclusive and binding upon such Holder and upon all future Holders
of this Security and of any Security issued upon the registration of transfer hereof or in exchange herefor or in lieu hereof,
whether or not notation of such consent or waiver is made upon this Security.


 






    A-7-9


     


    

 


No reference herein to the Indenture or
Supplemental Indenture and no provision of this Security or of the Indenture or Supplemental Indenture shall alter or impair the
obligation of the Company, which is absolute and unconditional, to pay the principal of and any premium and interest on this Security
at the times, place and rate, and in the coin or currency, herein prescribed.


 


As provided in the Indenture and subject
to certain limitations therein set forth, the transfer of this Security is registerable in the Security Register, upon surrender
of this Security for registration of transfer at the office or agency of the Company in any place where the principal of and any
premium and interest on this Security are payable, duly endorsed by, or accompanied by a written instrument of transfer in form
satisfactory to the Company and the Security Registrar duly executed by, the Holder hereof or his attorney duly authorized in writing,
and thereupon one or more new Securities of this series and of like tenor, of authorized denominations and for the same aggregate
principal amount, will be issued to the designated transferee or transferees.


 


The Securities of this series are issuable
only in registered form without coupons in denominations of $2,000 and any integral multiple of $1,000 in excess thereof. As provided
in the Indenture and subject to certain limitations therein set forth, Securities of this series are exchangeable for a like aggregate
principal amount of Securities of this series and of like tenor of a different authorized denomination, as requested by the Holder
surrendering the same.


 


No service charge shall be made for any
registration of transfer or exchange of the Notes, but the Company or the Security Registrar may require payment of a sum sufficient
to cover any transfer tax, assessments, or similar governmental charge payable in connection therewith (other than any such transfer
taxes, assessments or similar governmental charge payable upon exchange or transfer pursuant to Sections 9.6 or 11.7 of the Indenture).


 


Prior to due presentment of this Security
for registration of transfer, the Company, the Trustee and any agent of the Company or the Trustee will treat the Person in whose
name this Security is registered as the owner hereof for the purpose of receiving payments and for all other purposes, whether
or not this Security be overdue, and neither the Company, the Trustee nor any such agent shall be affected by notice to the contrary.


 


All terms used in this Security which are
defined in the Indenture and Supplemental Indenture shall have the meanings assigned to them in the Indenture and Supplemental
Indenture.


 


THIS SECURITY SHALL BE GOVERNED BY AND CONSTRUED
IN ACCORDANCE WITH THE LAWS OF THE STATE OF NEW YORK.


 


This Security is a Book-Entry Security within
the meaning of the Indenture hereinafter referred to and is registered in the name of a Depository or a nominee of a Depository.
This Security is exchangeable for Securities registered in the name of a person other than the Depository or its nominee only in
the limited circumstances described in the Indenture and may not be transferred except as a whole by the Depository to a nominee
of the Depository or by a nominee of the Depository to the Depository or another nominee of the Depository.


 


 


*                                        
*                                        
*


 






    A-7-10


     


    

 


SCHEDULE OF EXCHANGES


 


The following exchanges, redemptions or
purchases of a part of this Book-Entry Security have been made:


 


	Date of

Exchange/

Redemption/

Repurchase	Amount of

decrease in

Principal Amount

of this Book-

Entry

Security	Amount of

increase in

Principal Amount

of this Book-

Entry Security	Principal Amount

of this Book-

Entry

Security following

such decrease (or

increase)	Signature of

authorized

signatory of

Trustee
	 	 	 	 	 
	 	 	 	 	 
	 	 	 	 	 


 






    A-7-11


     


    

 


ASSIGNMENT FORM


 


To assign this Security, fill in the form below:


 


I or we assign and transfer this Security to


 


	 
	(Print or type assignee’s name, address and zip code)


 


	 
	(Insert assignee’s soc. sec. or tax I.D. No.)


 


and irrevocably appoint                               
as agent to transfer this Security on the books of the Company. The agent may substitute another to act for him.


 


Date:


 


Your Signature*:


 


By:


 


Name:


 


Title:


 


 


Sign exactly as your name appears on the
other side of this Security.


 


 


*Signature Guaranteed:


 


 


*NOTICE: The signature to this assignment must correspond with
the name as it appears upon the face of the within Note in every particular, without alteration, enlargement or any change whatever.
Such signature must be guaranteed by an “eligible guarantor institution” meeting the requirements of the Security Registrar,
which requirements include membership or participation in Security Transfer Agents Medallion Program (“STAMP”) or such
other “signature guarantee program” as may be determined by the Security Registrar in addition to, or in substitution
for, STAMP, all in accordance with the Securities Exchange Act of 1934, as amended.


 






    A-7-12


     


    

 


FORM OF TRANSFER CERTIFICATE


 


In connection with any transfer of any of
the Securities evidenced by this certificate occurring prior to the expiration of the period referred to in Rule 144 under
the Securities Act (“Rule 144”) after the later of the date of original issuance of such Notes and the last date,
if any, on which such Notes were owned by the Company or any Affiliate (as such term is defined in Rule 144) of the Company,
the undersigned confirms that such Securities are being transferred in accordance with its terms:


 


CHECK ONE BOX BELOW


 


		(1)	 ̈to the Company; or



 


		(2)	 ̈pursuant to an effective registration statement under the Securities Act; or



 


		(3)	 ̈inside the United States to a person reasonably believed to be a “qualified institutional buyer” (as
defined in Rule 144A under the Securities Act) that purchases for its own account or for the account of a qualified institutional
buyer to whom notice is given that such transfer is being made in reliance on Rule 144A, in each case pursuant to and in compliance
with Rule 144A under the Securities Act; or



 


		(4)	 ̈in an offshore transaction in compliance with Rule 903 or Rule 904 of Regulation S under the Securities
Act; or



 


		(5)	 ̈pursuant to the exemption from registration provided by Rule 144 under the Securities Act or any other available
exemption from the registration requirement of the Securities Act.



 


Unless one of the boxes is checked,
the Trustee shall refuse to register any of the Securities evidenced by this certificate in the name of any person other than the
registered holder thereof; provided, however, that if box (5) is checked, the Trustee shall be entitled to require, prior
to registering any such transfer of the Securities, such legal opinions, certifications and other information as the Company has
reasonably requested to confirm that such transfer is being made pursuant to an exemption from, or in a transaction not subject
to, the registration requirements of the Securities Act.


 


 


	 	 
	 	Signature


 






    A-7-13


     


    

 


TO BE COMPLETED BY PURCHASER IF (3) ABOVE
IS CHECKED.


 


The undersigned represents and warrants that it is purchasing
this Security for its own account or an account with respect to which it exercises sole investment discretion and that it and any
such account is a “qualified institutional buyer” within the meaning of Rule 144A under the Securities Act, and
is aware that the sale to it is being made in reliance on Rule 144A and acknowledges that it has received such information
regarding the Company as the undersigned has requested pursuant to Rule 144A or has determined not to request such information
and that it is aware that the transferor is relying upon the undersigned’s foregoing representations in order to claim the
exemption from registration provided by Rule 144A.


 


 


	Dated:	 	 	Notice: To be executed by an executive officer


 






    A-7-14


     


    

 


FORM OF EXCHANGE CERTIFICATE


 


AbbVie Inc.


1 North Waukegan Road


North Chicago, Illinois
60064


 


U.S. Bank National Association


190 South LaSalle Street, 10th Floor


Chicago, IL 60603


Attention: Corporate Trust Services


 


Re: 2.950% Senior Notes due
2026


 


Reference is hereby made to the Indenture,
dated as of November 8, 2012 (the “Base Indenture”), as supplemented by the First Supplemental Indenture, dated
as of November 8, 2012, the Second Supplemental Indenture, dated as of May 14, 2015, the Third Supplemental Indenture,
dated as of May 12, 2016, the Fourth Supplemental Indenture, dated as of November 17, 2016, the Fifth Supplemental Indenture,
dated as of September 18, 2018, the Sixth Supplemental Indenture, dated as of September 26, 2019 and the Seventh Supplemental
Indenture, dated as of November 21, 2019 (as so supplemented, the “Indenture”), between AbbVie Inc. (the “Company”)
and U.S. Bank National Association, a national banking association as trustee. Capitalized terms used but not defined herein shall
have the meanings given to them in the Indenture.


 


                   
 (the “Owner”) owns and proposes to exchange the Security[ies] or interest in such Security[ies]
specified herein, in the principal amount of $                     
in such Security[ies] or interests (the “Exchange”). In connection with the Exchange, the Owner hereby certifies that
in connection with the Exchange of the Owner’s Regulation S Global Note for a beneficial interest in the Rule 144A
Global Note, with an equal principal amount, the Security[ies] or interest in such Security[ies] specified herein [is][are] being
transferred to a Person (A) who the transferor reasonably believes to be a QIB, (B) purchasing for its own account or
the account of a QIB in a transaction meeting the requirements of Rule 144A, and (C) in accordance with all applicable
securities laws of the States of the United States and other jurisdictions.


 


This certificate and the statements contained
herein are made for your benefit and the benefit of the Company and are dated                       .


 


	 	[Insert Name of Transferor]
	 	 
	 	By:	 
	 	 	Name:
	 	 	Title:
	 
	 
	Dated: 	 	:
	 	 	 	 	 


 








    A-7-15


     


    





 


EXHIBIT A8


 


(FORM OF FACE OF INITIAL NOTE)


 


[THIS SECURITY IS A GLOBAL SECURITY WITHIN THE MEANING OF THE
INDENTURE HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME OF A DEPOSITARY OR A NOMINEE OF A DEPOSITARY. UNLESS AND UNTIL
IT IS EXCHANGED IN WHOLE OR IN PART FOR SECURITIES IN DEFINITIVE FORM IN ACCORDANCE WITH THE PROVISIONS OF THE INDENTURE AND THE
TERMS OF THE SECURITIES, TRANSFERS OF THIS GLOBAL SECURITY SHALL BE LIMITED TO TRANSFERS IN WHOLE, BUT NOT IN PART, TO THE DEPOSITORY
TRUST COMPANY, A NEW YORK CORPORATION (“DTC”), TO NOMINEES OF DTC OR TO A SUCCESSOR THEREOF OR SUCH SUCCESSOR’S
NOMINEE AND TRANSFERS OF PORTIONS OF THIS GLOBAL SECURITY SHALL BE LIMITED TO TRANSFERS MADE IN ACCORDANCE WITH THE RESTRICTIONS
SET FORTH IN THE INDENTURE REFERRED TO ON THE REVERSE HEREOF.


 


UNLESS THIS CERTIFICATE IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE
OF DTC, TO ABBVIE INC., OR ITS AGENT FOR REGISTRATION OF TRANSFER, EXCHANGE OR PAYMENT, AND ANY CERTIFICATE ISSUED IS REGISTERED
IN THE NAME OF CEDE & CO. OR IN SUCH OTHER NAME AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC (AND ANY PAYMENT IS
MADE TO CEDE & CO. OR TO SUCH OTHER ENTITY AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC), ANY TRANSFER, PLEDGE OR
OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL INASMUCH AS THE REGISTERED OWNER HEREOF, CEDE & CO.,
HAS AN INTEREST HEREIN.](1)


 


THIS SECURITY HAS NOT BEEN REGISTERED UNDER THE SECURITIES ACT
OF 1933, AS AMENDED (THE “SECURITIES ACT”), OR THE SECURITIES LAWS OF ANY STATE OR OTHER JURISDICTION.


 


NEITHER THIS SECURITY NOR ANY INTEREST OR PARTICIPATION HEREIN
MAY BE REOFFERED, SOLD, ASSIGNED, TRANSFERRED, PLEDGED, ENCUMBERED OR OTHERWISE DISPOSED OF IN THE ABSENCE OF SUCH REGISTRATION
OR UNLESS SUCH TRANSACTION IS EXEMPT FROM, OR NOT SUBJECT TO, SUCH REGISTRATION. THE HOLDER OF THIS SECURITY, BY ITS ACCEPTANCE
HEREOF, AGREES ON ITS OWN BEHALF AND ON BEHALF OF ANY INVESTOR ACCOUNT FOR WHICH IT HAS PURCHASED SECURITIES, TO OFFER, SELL OR
OTHERWISE TRANSFER SUCH SECURITY, PRIOR TO THE DATE (THE “RESALE RESTRICTION TERMINATION DATE”) THAT IS [IN THE CASE
OF RULE 144A NOTES: ONE YEAR] [IN THE CASE OF REGULATION S NOTES: 40 DAYS] AFTER THE LATER OF THE ISSUE DATE HEREOF OR ANY OTHER
ISSUE DATE IN RESPECT OF A FURTHER ISSUANCE OF SECURITIES OF THE SAME SERIES AND THE LAST DATE ON WHICH ABBVIE INC. OR ANY AFFILIATE
OF ABBVIE INC. WAS THE OWNER OF THIS SECURITY (OR ANY PREDECESSOR OF SUCH SECURITY), ONLY (A) TO ABBVIE INC. OR ANY SUBSIDIARY
THEREOF, (B) PURSUANT TO A REGISTRATION STATEMENT THAT HAS BEEN DECLARED EFFECTIVE UNDER THE SECURITIES ACT, (C) FOR SO LONG AS THE SECURITIES ARE ELIGIBLE FOR
RESALE PURSUANT TO RULE 144A UNDER THE SECURITIES ACT (“RULE 144A”), TO A PERSON IT REASONABLY BELIEVES IS
A ‘‘QUALIFIED INSTITUTIONAL BUYER’’ AS DEFINED IN RULE 144A THAT PURCHASES FOR ITS OWN ACCOUNT OR
FOR THE ACCOUNT OF A QUALIFIED INSTITUTIONAL BUYER TO WHOM NOTICE IS GIVEN THAT THE TRANSFER IS BEING MADE IN RELIANCE ON RULE
144A IN A TRANSACTION MEETING THE REQUIREMENTS OF RULE 144A, (D) PURSUANT TO OFFERS AND SALES TO NON-U.S. PERSONS THAT
OCCUR OUTSIDE THE UNITED STATES WITHIN THE MEANING OF REGULATION S UNDER THE SECURITIES ACT, (E) TO AN INSTITUTIONAL
 “ACCREDITED INVESTOR” WITHIN THE MEANING OF RULE 501(a)(1), (2), (3) OR (7) UNDER THE SECURITIES ACT THAT IS NOT
A QUALIFIED INSTITUTIONAL BUYER AND THAT IS PURCHASING FOR ITS OWN ACCOUNT OR FOR THE ACCOUNT OF ANOTHER INSTITUTIONAL ACCREDITED
INVESTOR, IN EACH CASE IN A MINIMUM PRINCIPAL AMOUNT OF THE SECURITIES OF $250,000, FOR INVESTMENT PURPOSES AND NOT WITH A VIEW
TO OR FOR OFFER OR SALE IN CONNECTION WITH ANY DISTRIBUTION IN VIOLATION OF THE SECURITIES ACT OR (F) PURSUANT TO ANOTHER
AVAILABLE EXEMPTION FROM THE REGISTRATION REQUIREMENTS OF THE SECURITIES ACT, SUBJECT TO ABBVIE INC.’S AND THE TRUSTEE’S
RIGHT PRIOR TO ANY SUCH OFFER, SALE OR TRANSFER PURSUANT TO CLAUSES (D), (E) OR (F) TO REQUIRE THE DELIVERY OF AN OPINION
OF COUNSEL, CERTIFICATION AND/OR OTHER INFORMATION SATISFACTORY TO EACH OF THEM.


 






    	 	 A-8-1 	 



     


    

  


[EACH PURCHASER OF THIS SECURITY IS HEREBY NOTIFIED THAT THE
SELLER OF THIS SECURITY MAY BE RELYING ON THE EXEMPTION FROM THE PROVISIONS OF SECTION 5 OF THE SECURITIES ACT PROVIDED BY
RULE 144A THEREUNDER.](2)


 


[BY ITS ACQUISITION HEREOF, THE HOLDER HEREOF REPRESENTS THAT
IT IS NOT A U.S. PERSON NOR IS IT PURCHASING FOR THE ACCOUNT OF A U.S. PERSON AND IS ACQUIRING THIS SECURITY IN AN OFFSHORE TRANSACTION
IN ACCORDANCE WITH REGULATION S UNDER THE SECURITIES ACT.](3)


 


[IN CONNECTION WITH ANY TRANSFER, THE HOLDER WILL DELIVER TO
THE REGISTRAR AND TRANSFER AGENT SUCH CERTIFICATES AND OTHER INFORMATION AS SUCH TRANSFER AGENT MAY REASONABLY REQUIRE TO CONFIRM
THAT THE TRANSFER COMPLIES WITH THE FOREGOING RESTRICTIONS.](4)


 


(1) Applies to Global Notes only


 


(2) Applies to Rule 144A Notes only


 


(3) Applies to Regulation S Notes only


 


(4) Applies to Notes in definitive form
only


 






    	 	 A-8-2 	 



     


    

 


ABBVIE INC.


 


3.200% Senior Notes due 2029


 


	No. [●]	 	$[●]



 


CUSIP No: [●]


 


ISIN No: [●]


 


ABBVIE INC., a corporation duly organized
and existing under the laws of Delaware (herein called the “Company,” which term includes any successor Person
under the Indenture and Supplemental Indenture hereinafter referred to), for value received, hereby promises to pay to Cede &
Co., as nominee for The Depository Trust Company, or registered assigns, the principal sum of [●] Dollars ($[●]), or
such other principal sum as may be indicated on the Schedule of Exchanges attached hereto, on November 21, 2029, and to pay interest
thereon from November 21, 2019 or from the most recent Interest Payment Date to which interest has been paid or duly provided for,
semi-annually in arrears on May 21 and November 21 of each year, commencing on May 21, 2020, at the rate of 3.200% per annum, until
the principal hereof is paid or made available for payment. The interest so payable, and punctually paid or duly provided for,
on any Interest Payment Date will, as provided in such Indenture, be paid to the Person in whose name this Security (or one or
more Predecessor Securities) is registered at the close of business on the Regular Record Date for such interest, which shall be
the date that is 15 calendar days prior to the relevant Interest Payment Date (whether or not a Business Day). Any such interest
not so punctually paid or duly provided for will forthwith cease to be payable to the Holder on such Regular Record Date and may
either be paid to the Person in whose name this Security (or one or more Predecessor Securities) is registered at the close of
business on a Special Record Date for the payment of such Defaulted Interest to be fixed by the Trustee, notice whereof shall be
given to Holders of Securities of this series not less than 10 days prior to such Special Record Date, or be paid at any time in
any other lawful manner not inconsistent with the requirements of any securities exchange on which the Securities of this series
may be listed, and upon such notice as may be required by such exchange, all as more fully provided in said Indenture.


 


Payment of the principal of (and premium,
if any) and any such interest on this Security will be made at the office or agency of the Company maintained for that purpose
in St. Paul, Minnesota, in such coin or currency of the United States of America as at the time of payment is legal tender for
payment of public and private debts; provided, however, that at the option of the Company payment of interest may be made by (1) check
mailed to the address of the Person entitled thereto as such address shall appear in the Security Register or (2) wire transfer
as directed by the Holder, in immediately available funds to an account maintained by the Depository or its nominee with respect
to a Global Note, and to the Holder or its nominee with respect to a Definitive Note; provided further that in the case of a Definitive
Note (1) the Holder thereof shall have provided written wiring instructions to the Trustee on or before the related Regular
Record Date and (2) if appropriate instructions for any such wire transfer are not received by the related Regular Record
Date, then such payment shall be made by check mailed to the address of the Holder specified in the Security Register.


 









    	 	 A-8-3 	 



     


    

   


Reference is hereby made to the further
provisions of this Security set forth on the reverse hereof, which further provisions shall for all purposes have the same effect
as if set forth at this place.


 


Unless the certificate of authentication
hereon has been executed by the Trustee referred to herein by manual signature, this Security shall not be entitled to any benefit
under the Indenture or be valid or obligatory for any purpose.



 






    	 	 A-8-4 	 



     


    

 



IN WITNESS WHEREOF, the Company has caused
this instrument to be duly executed.


 


Dated: November 21, 2019


 


 


	 	ABBVIE INC.
	 	 	 
	 	By:	 
	 	 	Name:
	 	 	Title:




 






    	 	 A-8-5 	 



     


    

 


TRUSTEE’S CERTIFICATE OF AUTHENTICATION


 


This is one of the Securities of the series
designated therein referred to in the within-mentioned Indenture.


 


Dated: November 21, 2019


 


  


	 	U.S. BANK NATIONAL ASSOCIATION, as Trustee
	 	 	 
	 	By:	 
	 	 	Authorized Signatory




 



    	 	 A-8-6 	 



     


    

 


[FORM OF REVERSE OF SECURITY]


 


This Security is one of a duly authorized
issue of securities of the Company (herein called the “Securities”), issued and to be issued in one or more
series under an Indenture, dated as of November 8, 2012, as it may be supplemented or amended from time to time (herein called
the “Indenture”), between the Company and U.S. Bank National Association, as Trustee (herein called the “Trustee,”
which term includes any successor trustee under the Indenture), and Supplemental Indenture No. 7, dated as of November 21,
2019 (herein called the “Supplemental Indenture”), between the Company and the Trustee, to which Indenture,
Supplemental Indenture and all indentures supplemental thereto reference is hereby made for a statement of the respective rights,
limitations of rights, duties and immunities thereunder of the Company, the Trustee and the Holders of the Securities of this series
and of the terms upon which the Securities of this series are, and are to be, authenticated and delivered. This Security is one
of the series designated on the face hereof, in an initial aggregate principal amount of $[●].


 


Optional Redemption 


 


At any time prior to the Par Call Date (as
defined below), the Company may redeem some or all of the Securities of this series at its option, in each case at a redemption
price equal to the greater of: (i) 100% of the principal amount of the Securities of this series to be redeemed; and (ii) the sum
of the present values of the remaining scheduled payments (through the Par Call Date assuming for such purpose that such Securities
matured on the Par Call Date) of principal and interest on the Securities of this series to be redeemed (exclusive of interest
accrued to the Redemption Date) discounted to the Redemption Date on a semiannual basis (assuming a 360-day year consisting of
twelve 30-day months) at the then current Treasury Rate plus 20 basis points.


 


The Company will pay accrued and unpaid
interest on the principal amount of the Securities of this series being redeemed to, but excluding, the Redemption Date.


 


In addition, at any time on or after the
Par Call Date, the Company may redeem some or all of the Securities of this series at its option at a redemption price equal to
100% of the principal amount of the Securities of this series to be redeemed, plus accrued and unpaid interest on the principal
amount of Securities of this series being redeemed to, but excluding, the Redemption Date.


 


If the Company has given notice as provided
in the Indenture and funds for the redemption of any Securities of this series called for redemption have been made available on
the Redemption Date in accordance with the Indenture, such Securities will cease to bear interest on the date fixed for redemption.
Thereafter, the only right of the Holders of such Securities will be to receive payment of the redemption price.


  






    	 	 A-8-7 	 



     


    

 


The Company will give notice of any optional
redemption, electronically or by mail, to Holders at their addresses, as shown in the Security Register for such Securities, or
as otherwise in accordance with the applicable procedures of DTC, not more than 60 nor less than 15 days prior to the date fixed
for redemption. The notice of redemption will specify, among other items, the Redemption Date, redemption price, the principal
amount of the Securities of this series to be redeemed and the place or places that payment will be made upon
surrender of the Securities of this series to be redeemed. Any redemption or notice of redemption may, at the Company’s discretion,
be subject to one or more conditions precedent, and, at the Company’s discretion, the redemption date may be delayed until
such time as any or all such conditions shall be satisfied. The Company shall provide written notice to the Trustee prior to the
close of business two Business Days prior to the redemption date if any such redemption has been rescinded or delayed, and upon
receipt the Trustee shall provide such notice to each holder of the Securities in the same manner in which the notice of redemption
was given.


 


The Company will notify the Trustee at least
30 days prior to the Redemption Date fixed by the Company (or such shorter period as is satisfactory to the Trustee) of the aggregate
principal amount of the Securities of this series to be redeemed and their Redemption Date. If less than all of the Securities
of this series are to be redeemed at any time, the Trustee shall select, not more than 30 days prior to the Redemption Date, which
Securities or the portion thereof, that are to be redeemed from the outstanding Securities of this series not previously redeemed
by random lot.


 


“Comparable Treasury Issue”
means the United States Treasury security selected by the Independent Investment Banker as having a maturity comparable to the
remaining term (assuming, for this purpose, that the Securities matured on the Par Call Date) (“Remaining Life”) of
the Securities of this series to be redeemed that would be utilized, at the time of selection and in accordance with customary
financial practice, in pricing new issues of corporate debt securities of comparable maturity to the Remaining Life of such Securities
(assuming, for this purpose, that the Securities matured on the Par Call Date).


 


“Comparable Treasury Price”
means, with respect to any Redemption Date, (1) if the Company obtains four or more Reference Treasury Dealer Quotations for
such Redemption Date, the average of such Reference Treasury Dealer Quotations, after excluding the highest and lowest Reference
Treasury Dealer Quotations, or (2) if the Company obtains fewer than four such Reference Treasury Dealer Quotations, the average
of all such quotations.


 


“Independent Investment Banker”
means one of the Reference Treasury Dealers that the Company appoints to act as the Independent Investment Banker from time to
time.


 


“Business Day” means
any calendar day that is not a Saturday, Sunday or legal holiday in New York, New York and on which commercial banks are open for
business in New York, New York.


 


“Par Call Date” means
August 21, 2029 (three months prior to the maturity date of the Securities of this series).


 


“Primary Treasury Dealer”
means a primary United States government securities dealer in the United States of America.


 


“Reference Treasury
Dealer” means (i) each of Morgan Stanley & Co. LLC, BofA Securities, Inc., Barclays Capital Inc. and
any of their respective successors; provided, however, that if any of them ceases to be a Primary Treasury Dealer, the
Company will substitute therefor another Primary Treasury Dealer and (ii) any other Primary
Treasury Dealers the Company selects.


 






    	 	 A-8-8 	 



     


    

  


“Reference Treasury Dealer Quotations”
means, with respect to each Reference Treasury Dealer and any Redemption Date, the average, as determined by the Company, of the
bid and asked prices for the Comparable Treasury Issue (expressed in each case as a percentage of its principal amount) quoted
in writing to the Company by such Reference Treasury Dealer at 3:30 p.m., New York City time, on the third Business Day preceding
such Redemption Date.


 


“Treasury Rate” means,
with respect to any Redemption Date, (1) the rate per annum equal to the yield, under the heading which represents the average
for the immediately preceding week, appearing in the most recently published statistical release designated “H.15(519)”
or any successor publication which is published weekly by the Board of Governors of the Federal Reserve System and which establishes
yields on actively traded United States Treasury securities adjusted to constant maturity under the caption “Treasury Constant
Maturities” for the maturity corresponding to the Comparable Treasury Issue; provided that, if no maturity is within three
months before or after the Remaining Life of the Securities of this series to be redeemed, yields for the two published maturities
most closely corresponding to the Comparable Treasury Issue shall be determined and the Treasury Rate shall be interpolated or
extrapolated from those yields on a straight line basis, rounding to the nearest month; or (2) if such release (or any successor
release) is not published during the week preceding the calculation date or does not contain such yields, the rate per year equal
to the semiannual equivalent yield to maturity of the Comparable Treasury Issue, calculated using a price for the Comparable Treasury
Issue (expressed as a percentage of its principal amount) equal to the Comparable Treasury Price for such Redemption Date. The
Treasury Rate shall be calculated on the third Business Day preceding the Redemption Date.


 


Special Mandatory Redemption 


 


If (i)
the consummation of the Acquisition (as defined below) does not occur on or before January 30, 2021 or (ii) the Company notifies
the Trustee that the Company will not pursue the consummation of the Acquisition (each of (i) and (ii), a “Special Mandatory
Redemption Trigger”), the Company will be required to redeem the Securities of this series then outstanding (such redemption,
the “Special Mandatory Redemption”) at a redemption price equal to 101% of the principal amount of such Securities
plus accrued and unpaid interest, if any, to, but not including, the Special Mandatory Redemption Date (the “Special Mandatory
Redemption Price”). The “Acquisition” means the acquisition by the Company of Allergan plc and its
subsidiaries pursuant to the definitive transaction agreement, dated as of June 25, 2019, by and among the Company, Venice Subsidiary
LLC, a Delaware limited liability company and a direct wholly owned subsidiary of the Company, and Allergan plc, as amended from
time to time.


 


In
the event that the Company becomes obligated to redeem the Securities of this series pursuant to the Special Mandatory
Redemption, the Company will promptly, and in any event not more than five Business Days after the date on which a Special
Mandatory Redemption Trigger occurred, deliver notice to the Trustee of the Special Mandatory Redemption and the date upon
which the Securities of this series will be redeemed (the “Special Mandatory Redemption Date,” which date
shall be no later than the third Business Day following the date of such notice) together with a notice of Special Mandatory
Redemption for the Trustee to deliver to each registered holder of the Securities of this series to be redeemed. The Trustee
will then promptly mail, or electronically deliver, according to the procedures of DTC, such notice of Special Mandatory
Redemption to each registered holder of the Securities of this series to be redeemed. Unless the Company defaults in payment
of the Special Mandatory Redemption Price, on and after such Special Mandatory Redemption Date, interest will cease to accrue
on the Securities of this series to be redeemed.


 






    	 	 A-8-9 	 



     


    

 


Failure to comply in any material respect
with any obligations in the provisions described under this caption “Special Mandatory Redemption” shall constitute
an “Event of Default” under Section 5.1(7) of the Indenture.


 


Notwithstanding the foregoing, installments
of interest on the Securities of this series that are due and payable on Interest Payment Dates falling on or prior to the Special
Mandatory Redemption Date will be payable on such Interest Payment Dates to the Holder as of the close of business on the relevant
Record Dates in accordance with the Securities of this series and the Indenture.


 


For the avoidance of doubt, Article Eleven
of the Indenture shall not apply to the Special Mandatory Redemption.


 


Sinking Fund 


 


The Securities of this series do not provide
for a sinking fund.


 


Default 


 


If an Event of Default with respect to Securities
of this series shall occur and be continuing, the principal of the Securities of this series may be declared due and payable in
the manner and with the effect provided in the Indenture.


 


Miscellaneous


 


The Indenture contains provisions for defeasance
at any time of the entire indebtedness of this Security or certain restrictive covenants and Events of Default with respect to
this Security, in each case upon compliance with certain conditions set forth therein. Sections 13.2 and 13.3 of the Indenture
apply to the Securities of this series.


 


The Indenture permits, with certain
exceptions as therein provided, the amendment thereof and the modification of the rights and obligations of the Company and
the rights of the Holders of the Securities of each series to be affected under the Indenture at any time by the Company and
the Trustee with the consent of the Holders of not less than a majority in principal amount of the Securities at the time
Outstanding of each series to be affected. The Indenture also contains provisions permitting the Holders of specified
percentages in principal amount of the Securities at the time Outstanding of any series, on behalf of the Holders of all
Securities of such series, to waive compliance by the Company with certain provisions of the Indenture and certain past
defaults under the Indenture and their consequences. Any such consent or waiver by the Holder of this Security shall be
conclusive and binding upon such Holder and upon all future Holders of this Security and of any Security issued upon the
registration of transfer hereof or in exchange herefor or in lieu hereof, whether or not notation of such consent or waiver
is made upon this Security.


 






    	 	 A-8-10 	 



     


    

 


No reference herein to the Indenture or
Supplemental Indenture and no provision of this Security or of the Indenture or Supplemental Indenture shall alter or impair the
obligation of the Company, which is absolute and unconditional, to pay the principal of and any premium and interest on this Security
at the times, place and rate, and in the coin or currency, herein prescribed.


 


As provided in the Indenture and subject
to certain limitations therein set forth, the transfer of this Security is registerable in the Security Register, upon surrender
of this Security for registration of transfer at the office or agency of the Company in any place where the principal of and any
premium and interest on this Security are payable, duly endorsed by, or accompanied by a written instrument of transfer in form
satisfactory to the Company and the Security Registrar duly executed by, the Holder hereof or his attorney duly authorized in writing,
and thereupon one or more new Securities of this series and of like tenor, of authorized denominations and for the same aggregate
principal amount, will be issued to the designated transferee or transferees.


 


The Securities of this series are issuable
only in registered form without coupons in denominations of $2,000 and any integral multiple of $1,000 in excess thereof. As provided
in the Indenture and subject to certain limitations therein set forth, Securities of this series are exchangeable for a like aggregate
principal amount of Securities of this series and of like tenor of a different authorized denomination, as requested by the Holder
surrendering the same.


 


No service charge shall be made for any
registration of transfer or exchange of the Notes, but the Company or the Security Registrar may require payment of a sum sufficient
to cover any transfer tax, assessments, or similar governmental charge payable in connection therewith (other than any such transfer
taxes, assessments or similar governmental charge payable upon exchange or transfer pursuant to Sections 9.6 or 11.7 of the Indenture).


 


Prior to due presentment of this Security
for registration of transfer, the Company, the Trustee and any agent of the Company or the Trustee will treat the Person in whose
name this Security is registered as the owner hereof for the purpose of receiving payments and for all other purposes, whether
or not this Security be overdue, and neither the Company, the Trustee nor any such agent shall be affected by notice to the contrary.


 


All terms used in this Security which are
defined in the Indenture and Supplemental Indenture shall have the meanings assigned to them in the Indenture and Supplemental
Indenture.


 


THIS SECURITY SHALL BE GOVERNED BY AND CONSTRUED
IN ACCORDANCE WITH THE LAWS OF THE STATE OF NEW YORK.


 


This Security is a Book-Entry
Security within the meaning of the Indenture hereinafter referred to and is registered in the name of a Depository or a
nominee of a Depository. This Security is exchangeable for Securities registered in the name of a person other than the
Depository or its nominee only in the limited circumstances described in the Indenture and may not be transferred except as a
whole by the Depository to a nominee of the Depository or by a nominee of the Depository to the Depository or another nominee
of the Depository.


 


*                                        
*                                        
*




 






    	 	 A-8-11 	 



     


    

 


SCHEDULE OF EXCHANGES


 


The following exchanges, redemptions or
purchases of a part of this Book-Entry Security have been made:


 


	Date of

Exchange/

Redemption/

Repurchase	Amount of

decrease in

Principal Amount

of this Book-Entry

Security	Amount of

increase in

Principal Amount

of this Book-

Entry Security	Principal Amount

of this Book-Entry

Security following

such decrease (or

increase)	Signature of

authorized

signatory of

Trustee
	 	 	 	 	 
	 	 	 	 	 
	 	 	 	 	 



 






    	 	 A-8-12 	 



     


    

 


ASSIGNMENT FORM


 


To assign this Security, fill in the form below:


 


I or we assign and transfer this Security to


  


	 
	(Print or type assignee’s name, address and zip code)


 


	 
	(Insert assignee’s soc. sec. or tax I.D. No.)


and irrevocably appoint                               
as agent to transfer this Security on the books of the Company. The agent may substitute another to act for him.


 


 


 


Date:


 


Your Signature*:


 


By:


 


Name:


 


Title:


   


Sign exactly as your name appears on the
other side of this Security.


  


 


*Signature Guaranteed:


 


  


*NOTICE: The signature to this assignment must correspond with
the name as it appears upon the face of the within Note in every particular, without alteration, enlargement or any change whatever.
Such signature must be guaranteed by an “eligible guarantor institution” meeting the requirements of the Security Registrar,
which requirements include membership or participation in Security Transfer Agents Medallion Program (“STAMP”) or such
other “signature guarantee program” as may be determined by the Security Registrar in addition to, or in substitution
for, STAMP, all in accordance with the Securities Exchange Act of 1934, as amended.


 






    	 	 A-8-13 	 



     


    

 


FORM OF TRANSFER CERTIFICATE


 


In connection with any transfer of any of
the Securities evidenced by this certificate occurring prior to the expiration of the period referred to in Rule 144 under
the Securities Act (“Rule 144”) after the later of the date of original issuance of such Notes and the last date,
if any, on which such Notes were owned by the Company or any Affiliate (as such term is defined in Rule 144) of the Company,
the undersigned confirms that such Securities are being transferred in accordance with its terms:


 


CHECK
ONE BOX BELOW


 


		(1)	 ̈  to the Company; or



 


		(2)	 ̈  pursuant to an effective registration statement under the Securities Act; or



 


		(3)	 ̈  inside the United States to a person reasonably believed to be a
                                                            “qualified institutional buyer” (as defined in Rule 144A under the Securities Act) that purchases for its own
                                                            account or for the account of a qualified institutional buyer to whom notice is given that such transfer is being made in
                                                            reliance on Rule 144A, in each case pursuant to and in compliance with Rule 144A under the Securities Act; or



 


		(4)	 ̈  in an offshore transaction in compliance with Rule 903 or Rule 904 of Regulation S under the Securities Act; or



 


		(5)	 ̈  pursuant to the exemption from registration provided by Rule 144 under the Securities Act or any other available
exemption from the registration requirement of the Securities Act.



 


Unless one of the boxes is checked,
the Trustee shall refuse to register any of the Securities evidenced by this certificate in the name of any person other than the
registered holder thereof; provided, however, that if box (5) is checked, the Trustee shall be entitled to require, prior
to registering any such transfer of the Securities, such legal opinions, certifications and other information as the Company has
reasonably requested to confirm that such transfer is being made pursuant to an exemption from, or in a transaction not subject
to, the registration requirements of the Securities Act.


 


	 	 
	 	Signature




 






    	 	 A-8-14 	 



     


    

  


TO BE COMPLETED
BY PURCHASER IF (3) ABOVE IS CHECKED.


 


The undersigned represents and warrants that it is purchasing
this Security for its own account or an account with respect to which it exercises sole investment discretion and that it and any
such account is a “qualified institutional buyer” within the meaning of Rule 144A under the Securities Act, and is
aware that the sale to it is being made in reliance on Rule 144A and acknowledges that it has received such information regarding
the Company as the undersigned has requested pursuant to Rule 144A or has determined not to request such information and that it
is aware that the transferor is relying upon the undersigned’s foregoing representations in order to claim the exemption
from registration provided by Rule 144A.


 


	Dated:	 	 	Notice: To be executed by an executive officer






 






    	 	 A-8-15 	 



     


    

  


FORM OF EXCHANGE CERTIFICATE


 


AbbVie Inc.


1 North Waukegan Road


North Chicago, Illinois 60064


 


U.S. Bank National Association


190 South LaSalle Street, 10th Floor


Chicago, IL 60603


Attention: Corporate Trust Services


 


Re: 3.200% Senior Notes due
2029


 


Reference is hereby made to the Indenture,
dated as of November 8, 2012 (the “Base Indenture”), as supplemented by the First Supplemental Indenture, dated as
of November 8, 2012, the Second Supplemental Indenture, dated as of May 14, 2015, the Third Supplemental Indenture, dated as of
May 12, 2016, the Fourth Supplemental Indenture, dated as of November 17, 2016, the Fifth Supplemental Indenture, dated as of September
18, 2018, the Sixth Supplemental Indenture, dated as of September 26, 2019 and the Seventh Supplemental Indenture, dated as of
November 21, 2019 (as so supplemented, the “Indenture”), between AbbVie Inc. (the “Company”) and U.S. Bank
National Association, a national banking association as trustee. Capitalized terms used but not defined herein shall have the meanings
given to them in the Indenture.


 


___________ (the “Owner”) owns
and proposes to exchange the Security[ies] or interest in such Security[ies] specified herein, in the principal amount of $__________
in such Security[ies] or interests (the “Exchange”). In connection with the Exchange, the Owner hereby certifies that
in connection with the Exchange of the Owner’s Regulation S Global Note for a beneficial interest in the Rule 144A Global
Note, with an equal principal amount, the Security[ies] or interest in such Security[ies] specified herein [is][are] being transferred
to a Person (A) who the transferor reasonably believes to be a QIB, (B) purchasing for its own account or the account of a QIB
in a transaction meeting the requirements of Rule 144A, and (C) in accordance with all applicable securities laws of the States
of the United States and other jurisdictions.


 


This certificate and the statements contained
herein are made for your benefit and the benefit of the Company and are dated ______________.


 


 


	 	[Insert Name of Transferor]
	 	 	 
	 	By:	 
	 	 	Name:
	 	 	Title:






 


	Dated: 	 	 	 


 






    	 	 A-8-16 	 



     


    

 



EXHIBIT A9


 


(FORM OF FACE OF INITIAL NOTE)


 


[THIS SECURITY IS A GLOBAL SECURITY WITHIN THE MEANING OF THE
INDENTURE HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME OF A DEPOSITARY OR A NOMINEE OF A DEPOSITARY. UNLESS AND UNTIL
IT IS EXCHANGED IN WHOLE OR IN PART FOR SECURITIES IN DEFINITIVE FORM IN ACCORDANCE WITH THE PROVISIONS OF THE INDENTURE AND THE
TERMS OF THE SECURITIES, TRANSFERS OF THIS GLOBAL SECURITY SHALL BE LIMITED TO TRANSFERS IN WHOLE, BUT NOT IN PART, TO THE DEPOSITORY
TRUST COMPANY, A NEW YORK CORPORATION (“DTC”), TO NOMINEES OF DTC OR TO A SUCCESSOR THEREOF OR SUCH SUCCESSOR’S
NOMINEE AND TRANSFERS OF PORTIONS OF THIS GLOBAL SECURITY SHALL BE LIMITED TO TRANSFERS MADE IN ACCORDANCE WITH THE RESTRICTIONS
SET FORTH IN THE INDENTURE REFERRED TO ON THE REVERSE HEREOF.


 


UNLESS THIS CERTIFICATE IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE
OF DTC, TO ABBVIE INC., OR ITS AGENT FOR REGISTRATION OF TRANSFER, EXCHANGE OR PAYMENT, AND ANY CERTIFICATE ISSUED IS REGISTERED
IN THE NAME OF CEDE & CO. OR IN SUCH OTHER NAME AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC (AND ANY PAYMENT IS
MADE TO CEDE & CO. OR TO SUCH OTHER ENTITY AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC), ANY TRANSFER, PLEDGE OR
OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL INASMUCH AS THE REGISTERED OWNER HEREOF, CEDE & CO.,
HAS AN INTEREST HEREIN.](1)


 


THIS SECURITY HAS NOT BEEN REGISTERED UNDER THE SECURITIES ACT
OF 1933, AS AMENDED (THE “SECURITIES ACT”), OR THE SECURITIES LAWS OF ANY STATE OR OTHER JURISDICTION.


 


NEITHER THIS SECURITY NOR ANY INTEREST OR PARTICIPATION HEREIN
MAY BE REOFFERED, SOLD, ASSIGNED, TRANSFERRED, PLEDGED, ENCUMBERED OR OTHERWISE DISPOSED OF IN THE ABSENCE OF SUCH REGISTRATION
OR UNLESS SUCH TRANSACTION IS EXEMPT FROM, OR NOT SUBJECT TO, SUCH REGISTRATION. THE HOLDER OF THIS SECURITY, BY ITS ACCEPTANCE
HEREOF, AGREES ON ITS OWN BEHALF AND ON BEHALF OF ANY INVESTOR ACCOUNT FOR WHICH IT HAS PURCHASED SECURITIES, TO OFFER, SELL OR
OTHERWISE TRANSFER SUCH SECURITY, PRIOR TO THE DATE (THE “RESALE RESTRICTION TERMINATION DATE”) THAT IS [IN THE CASE
OF RULE 144A NOTES: ONE YEAR] [IN THE CASE OF REGULATION S NOTES: 40 DAYS] AFTER THE LATER OF THE ISSUE DATE HEREOF OR ANY OTHER
ISSUE DATE IN RESPECT OF A FURTHER ISSUANCE OF SECURITIES OF THE SAME SERIES AND THE LAST DATE ON WHICH ABBVIE INC. OR ANY AFFILIATE
OF ABBVIE INC. WAS THE OWNER OF THIS SECURITY (OR ANY PREDECESSOR OF SUCH SECURITY), ONLY (A) TO ABBVIE INC. OR ANY SUBSIDIARY
THEREOF, (B) PURSUANT TO A REGISTRATION STATEMENT THAT HAS BEEN DECLARED EFFECTIVE UNDER THE SECURITIES ACT, (C) FOR SO LONG AS THE SECURITIES ARE ELIGIBLE FOR
RESALE PURSUANT TO RULE 144A UNDER THE SECURITIES ACT (“RULE 144A”), TO A PERSON IT REASONABLY BELIEVES IS
A ‘‘QUALIFIED INSTITUTIONAL BUYER’’ AS DEFINED IN RULE 144A THAT PURCHASES FOR ITS OWN ACCOUNT OR
FOR THE ACCOUNT OF A QUALIFIED INSTITUTIONAL BUYER TO WHOM NOTICE IS GIVEN THAT THE TRANSFER IS BEING MADE IN RELIANCE ON RULE
144A IN A TRANSACTION MEETING THE REQUIREMENTS OF RULE 144A, (D) PURSUANT TO OFFERS AND SALES TO NON-U.S. PERSONS THAT
OCCUR OUTSIDE THE UNITED STATES WITHIN THE MEANING OF REGULATION S UNDER THE SECURITIES ACT, (E) TO AN INSTITUTIONAL
 “ACCREDITED INVESTOR” WITHIN THE MEANING OF RULE 501(a)(1), (2), (3) OR (7) UNDER THE SECURITIES ACT THAT IS NOT
A QUALIFIED INSTITUTIONAL BUYER AND THAT IS PURCHASING FOR ITS OWN ACCOUNT OR FOR THE ACCOUNT OF ANOTHER INSTITUTIONAL ACCREDITED
INVESTOR, IN EACH CASE IN A MINIMUM PRINCIPAL AMOUNT OF THE SECURITIES OF $250,000, FOR INVESTMENT PURPOSES AND NOT WITH A VIEW
TO OR FOR OFFER OR SALE IN CONNECTION WITH ANY DISTRIBUTION IN VIOLATION OF THE SECURITIES ACT OR (F) PURSUANT TO ANOTHER
AVAILABLE EXEMPTION FROM THE REGISTRATION REQUIREMENTS OF THE SECURITIES ACT, SUBJECT TO ABBVIE INC.’S AND THE TRUSTEE’S
RIGHT PRIOR TO ANY SUCH OFFER, SALE OR TRANSFER PURSUANT TO CLAUSES (D), (E) OR (F) TO REQUIRE THE DELIVERY OF AN OPINION
OF COUNSEL, CERTIFICATION AND/OR OTHER INFORMATION SATISFACTORY TO EACH OF THEM.


 






    	 	 A-9-1 	 



     


    

  


[EACH PURCHASER OF THIS SECURITY IS HEREBY NOTIFIED THAT THE
SELLER OF THIS SECURITY MAY BE RELYING ON THE EXEMPTION FROM THE PROVISIONS OF SECTION 5 OF THE SECURITIES ACT PROVIDED BY
RULE 144A THEREUNDER.](2)


 


[BY ITS ACQUISITION HEREOF, THE HOLDER HEREOF REPRESENTS THAT
IT IS NOT A U.S. PERSON NOR IS IT PURCHASING FOR THE ACCOUNT OF A U.S. PERSON AND IS ACQUIRING THIS SECURITY IN AN OFFSHORE TRANSACTION
IN ACCORDANCE WITH REGULATION S UNDER THE SECURITIES ACT.](3)


 


[IN CONNECTION WITH ANY TRANSFER, THE HOLDER WILL DELIVER TO
THE REGISTRAR AND TRANSFER AGENT SUCH CERTIFICATES AND OTHER INFORMATION AS SUCH TRANSFER AGENT MAY REASONABLY REQUIRE TO CONFIRM
THAT THE TRANSFER COMPLIES WITH THE FOREGOING RESTRICTIONS.](4)


 


(1) Applies to Global Notes only


 


(2) Applies to Rule 144A Notes only


 


(3) Applies to Regulation S Notes only


 


(4) Applies to Notes in definitive form
only


 






    	 	 A-9-2 	 



     


    

 


ABBVIE INC.


 


4.050% Senior Notes due 2039


 


	No. [●]	 	$[●]



 


CUSIP No: [●]


 


ISIN No: [●]


 


ABBVIE INC., a corporation duly organized
and existing under the laws of Delaware (herein called the “Company,” which term includes any successor Person
under the Indenture and Supplemental Indenture hereinafter referred to), for value received, hereby promises to pay to Cede &
Co., as nominee for The Depository Trust Company, or registered assigns, the principal sum of [●] Dollars ($[●]), or
such other principal sum as may be indicated on the Schedule of Exchanges attached hereto, on November 21, 2039, and to pay interest
thereon from November 21, 2019 or from the most recent Interest Payment Date to which interest has been paid or duly provided for,
semi-annually in arrears on May 21 and November 21 of each year, commencing on May 21, 2020, at the rate of 4.050% per annum, until
the principal hereof is paid or made available for payment. The interest so payable, and punctually paid or duly provided for,
on any Interest Payment Date will, as provided in such Indenture, be paid to the Person in whose name this Security (or one or
more Predecessor Securities) is registered at the close of business on the Regular Record Date for such interest, which shall be
the date that is 15 calendar days prior to the relevant Interest Payment Date (whether or not a Business Day). Any such interest
not so punctually paid or duly provided for will forthwith cease to be payable to the Holder on such Regular Record Date and may
either be paid to the Person in whose name this Security (or one or more Predecessor Securities) is registered at the close of
business on a Special Record Date for the payment of such Defaulted Interest to be fixed by the Trustee, notice whereof shall be
given to Holders of Securities of this series not less than 10 days prior to such Special Record Date, or be paid at any time in
any other lawful manner not inconsistent with the requirements of any securities exchange on which the Securities of this series
may be listed, and upon such notice as may be required by such exchange, all as more fully provided in said Indenture.


 


Payment of the principal of (and premium,
if any) and any such interest on this Security will be made at the office or agency of the Company maintained for that purpose
in St. Paul, Minnesota, in such coin or currency of the United States of America as at the time of payment is legal tender for
payment of public and private debts; provided, however, that at the option of the Company payment of interest may be made by (1) check
mailed to the address of the Person entitled thereto as such address shall appear in the Security Register or (2) wire transfer
as directed by the Holder, in immediately available funds to an account maintained by the Depository or its nominee with respect
to a Global Note, and to the Holder or its nominee with respect to a Definitive Note; provided further that in the case of a Definitive
Note (1) the Holder thereof shall have provided written wiring instructions to the Trustee on or before the related Regular
Record Date and (2) if appropriate instructions for any such wire transfer are not received by the related Regular Record
Date, then such payment shall be made by check mailed to the address of the Holder specified in the Security Register.


 









    	 	 A-9-3 	 



     


    

   


Reference is hereby made to the further
provisions of this Security set forth on the reverse hereof, which further provisions shall for all purposes have the same effect
as if set forth at this place.


 


Unless the certificate of authentication
hereon has been executed by the Trustee referred to herein by manual signature, this Security shall not be entitled to any benefit
under the Indenture or be valid or obligatory for any purpose.



 






    	 	 A-9-4 	 



     


    

 



IN WITNESS WHEREOF, the Company has caused
this instrument to be duly executed.


 


Dated: November 21, 2019


 


 


	 	ABBVIE INC.
	 	 	 
	 	By:	 
	 	 	Name:
	 	 	Title:




 






    	 	 A-9-5 	 



     


    

 


TRUSTEE’S CERTIFICATE OF AUTHENTICATION


 


This is one of the Securities of the series
designated therein referred to in the within-mentioned Indenture.


 


Dated: November 21, 2019


 


  


	 	U.S. BANK NATIONAL ASSOCIATION, as Trustee
	 	 	 
	 	By:	 
	 	 	Authorized Signatory




 



    	 	 A-9-6 	 



     


    

 


[FORM OF REVERSE OF SECURITY]


 


This Security is one of a duly authorized
issue of securities of the Company (herein called the “Securities”), issued and to be issued in one or more
series under an Indenture, dated as of November 8, 2012, as it may be supplemented or amended from time to time (herein called
the “Indenture”), between the Company and U.S. Bank National Association, as Trustee (herein called the “Trustee,”
which term includes any successor trustee under the Indenture), and Supplemental Indenture No. 7, dated as of November 21,
2019 (herein called the “Supplemental Indenture”), between the Company and the Trustee, to which Indenture,
Supplemental Indenture and all indentures supplemental thereto reference is hereby made for a statement of the respective rights,
limitations of rights, duties and immunities thereunder of the Company, the Trustee and the Holders of the Securities of this series
and of the terms upon which the Securities of this series are, and are to be, authenticated and delivered. This Security is one
of the series designated on the face hereof, in an initial aggregate principal amount of $[●].


 


Optional Redemption 


 


At any time prior to the Par Call Date (as
defined below), the Company may redeem some or all of the Securities of this series at its option, in each case at a redemption
price equal to the greater of: (i) 100% of the principal amount of the Securities of this series to be redeemed; and (ii) the sum
of the present values of the remaining scheduled payments (through the Par Call Date assuming for such purpose that such Securities
matured on the Par Call Date) of principal and interest on the Securities of this series to be redeemed (exclusive of interest
accrued to the Redemption Date) discounted to the Redemption Date on a semiannual basis (assuming a 360-day year consisting of
twelve 30-day months) at the then current Treasury Rate plus 25 basis points.


 


The Company will pay accrued and unpaid
interest on the principal amount of the Securities of this series being redeemed to, but excluding, the Redemption Date.


 


In addition, at any time on or after the
Par Call Date, the Company may redeem some or all of the Securities of this series at its option at a redemption price equal to
100% of the principal amount of the Securities of this series to be redeemed, plus accrued and unpaid interest on the principal
amount of Securities of this series being redeemed to, but excluding, the Redemption Date.


 


If the Company has given notice as provided
in the Indenture and funds for the redemption of any Securities of this series called for redemption have been made available on
the Redemption Date in accordance with the Indenture, such Securities will cease to bear interest on the date fixed for redemption.
Thereafter, the only right of the Holders of such Securities will be to receive payment of the redemption price.


  






    	 	 A-9-7 	 



     


    

 


The Company will give notice of any optional
redemption, electronically or by mail, to Holders at their addresses, as shown in the Security Register for such Securities, or
as otherwise in accordance with the applicable procedures of DTC, not more than 60 nor less than 15 days prior to the date fixed
for redemption. The notice of redemption will specify, among other items, the Redemption Date, redemption price, the principal
amount of the Securities of this series to be redeemed and the place or places that payment will be made upon
surrender of the Securities of this series to be redeemed. Any redemption or notice of redemption may, at the Company’s discretion,
be subject to one or more conditions precedent, and, at the Company’s discretion, the redemption date may be delayed until
such time as any or all such conditions shall be satisfied. The Company shall provide written notice to the Trustee prior to the
close of business two Business Days prior to the redemption date if any such redemption has been rescinded or delayed, and upon
receipt the Trustee shall provide such notice to each holder of the Securities in the same manner in which the notice of redemption
was given.


 


The Company will notify the Trustee at least
30 days prior to the Redemption Date fixed by the Company (or such shorter period as is satisfactory to the Trustee) of the aggregate
principal amount of the Securities of this series to be redeemed and their Redemption Date. If less than all of the Securities
of this series are to be redeemed at any time, the Trustee shall select, not more than 30 days prior to the Redemption Date, which
Securities or the portion thereof, that are to be redeemed from the outstanding Securities of this series not previously redeemed
by random lot.


 


“Comparable Treasury Issue”
means the United States Treasury security selected by the Independent Investment Banker as having a maturity comparable to the
remaining term (assuming, for this purpose, that the Securities matured on the Par Call Date) (“Remaining Life”) of
the Securities of this series to be redeemed that would be utilized, at the time of selection and in accordance with customary
financial practice, in pricing new issues of corporate debt securities of comparable maturity to the Remaining Life of such Securities
(assuming, for this purpose, that the Securities matured on the Par Call Date).


 


“Comparable Treasury Price”
means, with respect to any Redemption Date, (1) if the Company obtains four or more Reference Treasury Dealer Quotations for
such Redemption Date, the average of such Reference Treasury Dealer Quotations, after excluding the highest and lowest Reference
Treasury Dealer Quotations, or (2) if the Company obtains fewer than four such Reference Treasury Dealer Quotations, the average
of all such quotations.


 


“Independent Investment Banker”
means one of the Reference Treasury Dealers that the Company appoints to act as the Independent Investment Banker from time to
time.


 


“Business Day” means
any calendar day that is not a Saturday, Sunday or legal holiday in New York, New York and on which commercial banks are open for
business in New York, New York.


 


“Par Call Date” means
May 21, 2039 (six months prior to the maturity date of the Securities of this series).


 


“Primary Treasury Dealer”
means a primary United States government securities dealer in the United States of America.


 


“Reference Treasury
Dealer” means (i) each of Morgan Stanley & Co. LLC, BofA Securities, Inc., Barclays Capital Inc. and
any of their respective successors; provided, however, that if any of them ceases to be a Primary Treasury Dealer, the
Company will substitute therefor another Primary Treasury Dealer and (ii) any other Primary
Treasury Dealers the Company selects.


 






    	 	 A-9-8 	 



     


    

  


“Reference Treasury Dealer Quotations”
means, with respect to each Reference Treasury Dealer and any Redemption Date, the average, as determined by the Company, of the
bid and asked prices for the Comparable Treasury Issue (expressed in each case as a percentage of its principal amount) quoted
in writing to the Company by such Reference Treasury Dealer at 3:30 p.m., New York City time, on the third Business Day preceding
such Redemption Date.


 


“Treasury Rate” means,
with respect to any Redemption Date, (1) the rate per annum equal to the yield, under the heading which represents the average
for the immediately preceding week, appearing in the most recently published statistical release designated “H.15(519)”
or any successor publication which is published weekly by the Board of Governors of the Federal Reserve System and which establishes
yields on actively traded United States Treasury securities adjusted to constant maturity under the caption “Treasury Constant
Maturities” for the maturity corresponding to the Comparable Treasury Issue; provided that, if no maturity is within three
months before or after the Remaining Life of the Securities of this series to be redeemed, yields for the two published maturities
most closely corresponding to the Comparable Treasury Issue shall be determined and the Treasury Rate shall be interpolated or
extrapolated from those yields on a straight line basis, rounding to the nearest month; or (2) if such release (or any successor
release) is not published during the week preceding the calculation date or does not contain such yields, the rate per year equal
to the semiannual equivalent yield to maturity of the Comparable Treasury Issue, calculated using a price for the Comparable Treasury
Issue (expressed as a percentage of its principal amount) equal to the Comparable Treasury Price for such Redemption Date. The
Treasury Rate shall be calculated on the third Business Day preceding the Redemption Date.


 


Special Mandatory Redemption 


 


If (i)
the consummation of the Acquisition (as defined below) does not occur on or before January 30, 2021 or (ii) the Company notifies
the Trustee that the Company will not pursue the consummation of the Acquisition (each of (i) and (ii), a “Special Mandatory
Redemption Trigger”), the Company will be required to redeem the Securities of this series then outstanding (such redemption,
the “Special Mandatory Redemption”) at a redemption price equal to 101% of the principal amount of such Securities
plus accrued and unpaid interest, if any, to, but not including, the Special Mandatory Redemption Date (the “Special Mandatory
Redemption Price”). The “Acquisition” means the acquisition by the Company of Allergan plc and its
subsidiaries pursuant to the definitive transaction agreement, dated as of June 25, 2019, by and among the Company, Venice Subsidiary
LLC, a Delaware limited liability company and a direct wholly owned subsidiary of the Company, and Allergan plc, as amended from
time to time.


 


In
the event that the Company becomes obligated to redeem the Securities of this series pursuant to the Special Mandatory
Redemption, the Company will promptly, and in any event not more than five Business Days after the date on which a Special
Mandatory Redemption Trigger occurred, deliver notice to the Trustee of the Special Mandatory Redemption and the date upon
which the Securities of this series will be redeemed (the “Special Mandatory Redemption Date,” which date
shall be no later than the third Business Day following the date of such notice) together with a notice of Special Mandatory
Redemption for the Trustee to deliver to each registered holder of the Securities of this series to be redeemed. The Trustee
will then promptly mail, or electronically deliver, according to the procedures of DTC, such notice of Special Mandatory
Redemption to each registered holder of the Securities of this series to be redeemed. Unless the Company defaults in payment
of the Special Mandatory Redemption Price, on and after such Special Mandatory Redemption Date, interest will cease to accrue
on the Securities of this series to be redeemed.


 






    	 	 A-9-9 	 



     


    

 


Failure to comply in any material respect
with any obligations in the provisions described under this caption “Special Mandatory Redemption” shall constitute
an “Event of Default” under Section 5.1(7) of the Indenture.


 


Notwithstanding the foregoing, installments
of interest on the Securities of this series that are due and payable on Interest Payment Dates falling on or prior to the Special
Mandatory Redemption Date will be payable on such Interest Payment Dates to the Holder as of the close of business on the relevant
Record Dates in accordance with the Securities of this series and the Indenture.


 


For the avoidance of doubt, Article Eleven
of the Indenture shall not apply to the Special Mandatory Redemption.


 


Sinking Fund 


 


The Securities of this series do not provide
for a sinking fund.


 


Default 


 


If an Event of Default with respect to Securities
of this series shall occur and be continuing, the principal of the Securities of this series may be declared due and payable in
the manner and with the effect provided in the Indenture.


 


Miscellaneous


 


The Indenture contains provisions for defeasance
at any time of the entire indebtedness of this Security or certain restrictive covenants and Events of Default with respect to
this Security, in each case upon compliance with certain conditions set forth therein. Sections 13.2 and 13.3 of the Indenture
apply to the Securities of this series.


 


The Indenture permits, with certain
exceptions as therein provided, the amendment thereof and the modification of the rights and obligations of the Company and
the rights of the Holders of the Securities of each series to be affected under the Indenture at any time by the Company and
the Trustee with the consent of the Holders of not less than a majority in principal amount of the Securities at the time
Outstanding of each series to be affected. The Indenture also contains provisions permitting the Holders of specified
percentages in principal amount of the Securities at the time Outstanding of any series, on behalf of the Holders of all
Securities of such series, to waive compliance by the Company with certain provisions of the Indenture and certain past
defaults under the Indenture and their consequences. Any such consent or waiver by the Holder of this Security shall be
conclusive and binding upon such Holder and upon all future Holders of this Security and of any Security issued upon the
registration of transfer hereof or in exchange herefor or in lieu hereof, whether or not notation of such consent or waiver
is made upon this Security.


 






    	 	 A-9-10 	 



     


    

 


No reference herein to the Indenture or
Supplemental Indenture and no provision of this Security or of the Indenture or Supplemental Indenture shall alter or impair the
obligation of the Company, which is absolute and unconditional, to pay the principal of and any premium and interest on this Security
at the times, place and rate, and in the coin or currency, herein prescribed.


 


As provided in the Indenture and subject
to certain limitations therein set forth, the transfer of this Security is registerable in the Security Register, upon surrender
of this Security for registration of transfer at the office or agency of the Company in any place where the principal of and any
premium and interest on this Security are payable, duly endorsed by, or accompanied by a written instrument of transfer in form
satisfactory to the Company and the Security Registrar duly executed by, the Holder hereof or his attorney duly authorized in writing,
and thereupon one or more new Securities of this series and of like tenor, of authorized denominations and for the same aggregate
principal amount, will be issued to the designated transferee or transferees.


 


The Securities of this series are issuable
only in registered form without coupons in denominations of $2,000 and any integral multiple of $1,000 in excess thereof. As provided
in the Indenture and subject to certain limitations therein set forth, Securities of this series are exchangeable for a like aggregate
principal amount of Securities of this series and of like tenor of a different authorized denomination, as requested by the Holder
surrendering the same.


 


No service charge shall be made for any
registration of transfer or exchange of the Notes, but the Company or the Security Registrar may require payment of a sum sufficient
to cover any transfer tax, assessments, or similar governmental charge payable in connection therewith (other than any such transfer
taxes, assessments or similar governmental charge payable upon exchange or transfer pursuant to Sections 9.6 or 11.7 of the Indenture).


 


Prior to due presentment of this Security
for registration of transfer, the Company, the Trustee and any agent of the Company or the Trustee will treat the Person in whose
name this Security is registered as the owner hereof for the purpose of receiving payments and for all other purposes, whether
or not this Security be overdue, and neither the Company, the Trustee nor any such agent shall be affected by notice to the contrary.


 


All terms used in this Security which are
defined in the Indenture and Supplemental Indenture shall have the meanings assigned to them in the Indenture and Supplemental
Indenture.


 


THIS SECURITY SHALL BE GOVERNED BY AND CONSTRUED
IN ACCORDANCE WITH THE LAWS OF THE STATE OF NEW YORK.


 


This Security is a Book-Entry
Security within the meaning of the Indenture hereinafter referred to and is registered in the name of a Depository or a
nominee of a Depository. This Security is exchangeable for Securities registered in the name of a person other than the
Depository or its nominee only in the limited circumstances described in the Indenture and may not be transferred except as a
whole by the Depository to a nominee of the Depository or by a nominee of the Depository to the Depository or another nominee
of the Depository.


 


*                                        
*                                        
*




 






    	 	 A-9-11 	 



     


    

 


SCHEDULE OF EXCHANGES


 


The following exchanges, redemptions or
purchases of a part of this Book-Entry Security have been made:


 


	Date of

Exchange/

Redemption/

Repurchase	Amount of

decrease in

Principal Amount

of this Book-Entry

Security	Amount of

increase in

Principal Amount

of this Book-

Entry Security	Principal Amount

of this Book-Entry

Security following

such decrease (or

increase)	Signature of

authorized

signatory of

Trustee
	 	 	 	 	 
	 	 	 	 	 
	 	 	 	 	 



 






    	 	 A-9-12 	 



     


    

 


ASSIGNMENT FORM


 


To assign this Security, fill in the form below:


 


I or we assign and transfer this Security to


  


	 
	(Print or type assignee’s name, address and zip code)


 


	 
	(Insert assignee’s soc. sec. or tax I.D. No.)


and irrevocably appoint                               
as agent to transfer this Security on the books of the Company. The agent may substitute another to act for him.


 


 


 


Date:


 


Your Signature*:


 


By:


 


Name:


 


Title:


   


Sign exactly as your name appears on the
other side of this Security.


  


 


*Signature Guaranteed:


 


  


*NOTICE: The signature to this assignment must correspond with
the name as it appears upon the face of the within Note in every particular, without alteration, enlargement or any change whatever.
Such signature must be guaranteed by an “eligible guarantor institution” meeting the requirements of the Security Registrar,
which requirements include membership or participation in Security Transfer Agents Medallion Program (“STAMP”) or such
other “signature guarantee program” as may be determined by the Security Registrar in addition to, or in substitution
for, STAMP, all in accordance with the Securities Exchange Act of 1934, as amended.


 






    	 	 A-9-13 	 



     


    

 


FORM OF TRANSFER CERTIFICATE


 


In connection with any transfer of any of
the Securities evidenced by this certificate occurring prior to the expiration of the period referred to in Rule 144 under
the Securities Act (“Rule 144”) after the later of the date of original issuance of such Notes and the last date,
if any, on which such Notes were owned by the Company or any Affiliate (as such term is defined in Rule 144) of the Company,
the undersigned confirms that such Securities are being transferred in accordance with its terms:


 


CHECK
ONE BOX BELOW


 


		(1)	 ̈  to the Company; or



 


		(2)	 ̈  pursuant to an effective registration statement under the Securities Act; or



 


		(3)	 ̈  inside the United States to a person reasonably believed to be a
                                                            “qualified institutional buyer” (as defined in Rule 144A under the Securities Act) that purchases for its own
                                                            account or for the account of a qualified institutional buyer to whom notice is given that such transfer is being made in
                                                            reliance on Rule 144A, in each case pursuant to and in compliance with Rule 144A under the Securities Act; or



 


		(4)	 ̈  in an offshore transaction in compliance with Rule 903 or Rule 904 of Regulation S under the Securities Act; or



 


		(5)	 ̈  pursuant to the exemption from registration provided by Rule 144 under the Securities Act or any other available
exemption from the registration requirement of the Securities Act.



 


Unless one of the boxes is checked,
the Trustee shall refuse to register any of the Securities evidenced by this certificate in the name of any person other than the
registered holder thereof; provided, however, that if box (5) is checked, the Trustee shall be entitled to require, prior
to registering any such transfer of the Securities, such legal opinions, certifications and other information as the Company has
reasonably requested to confirm that such transfer is being made pursuant to an exemption from, or in a transaction not subject
to, the registration requirements of the Securities Act.


 


	 	 
	 	Signature




 






    	 	 A-9-14 	 



     


    

  


TO BE COMPLETED
BY PURCHASER IF (3) ABOVE IS CHECKED.


 


The undersigned represents and warrants that it is purchasing
this Security for its own account or an account with respect to which it exercises sole investment discretion and that it and any
such account is a “qualified institutional buyer” within the meaning of Rule 144A under the Securities Act, and is
aware that the sale to it is being made in reliance on Rule 144A and acknowledges that it has received such information regarding
the Company as the undersigned has requested pursuant to Rule 144A or has determined not to request such information and that it
is aware that the transferor is relying upon the undersigned’s foregoing representations in order to claim the exemption
from registration provided by Rule 144A.


 


	Dated:	 	 	Notice: To be executed by an executive officer






 






    	 	 A-9-15 	 



     


    

  


FORM OF EXCHANGE CERTIFICATE


 


AbbVie Inc.


1 North Waukegan Road


North Chicago, Illinois 60064


 


U.S. Bank National Association


190 South LaSalle Street, 10th Floor


Chicago, IL 60603


Attention: Corporate Trust Services


 


Re: 4.050% Senior Notes due
2039


 


Reference is hereby made to the Indenture,
dated as of November 8, 2012 (the “Base Indenture”), as supplemented by the First Supplemental Indenture, dated as
of November 8, 2012, the Second Supplemental Indenture, dated as of May 14, 2015, the Third Supplemental Indenture, dated as of
May 12, 2016, the Fourth Supplemental Indenture, dated as of November 17, 2016, the Fifth Supplemental Indenture, dated as of September
18, 2018, the Sixth Supplemental Indenture, dated as of September 26, 2019 and the Seventh Supplemental Indenture, dated as of
November 21, 2019 (as so supplemented, the “Indenture”), between AbbVie Inc. (the “Company”) and U.S. Bank
National Association, a national banking association as trustee. Capitalized terms used but not defined herein shall have the meanings
given to them in the Indenture.


 


___________ (the “Owner”) owns
and proposes to exchange the Security[ies] or interest in such Security[ies] specified herein, in the principal amount of $__________
in such Security[ies] or interests (the “Exchange”). In connection with the Exchange, the Owner hereby certifies that
in connection with the Exchange of the Owner’s Regulation S Global Note for a beneficial interest in the Rule 144A Global
Note, with an equal principal amount, the Security[ies] or interest in such Security[ies] specified herein [is][are] being transferred
to a Person (A) who the transferor reasonably believes to be a QIB, (B) purchasing for its own account or the account of a QIB
in a transaction meeting the requirements of Rule 144A, and (C) in accordance with all applicable securities laws of the States
of the United States and other jurisdictions.


 


This certificate and the statements contained
herein are made for your benefit and the benefit of the Company and are dated _________.


 


 


	 	[Insert Name of Transferor]
	 	 	 
	 	By:	 
	 	 	Name:
	 	 	Title:






 


	Dated: 	 	 	 


 






    	 	 A-9-16 	 



     


    

 


 



 


EXHIBIT A10


 


(FORM OF FACE OF INITIAL NOTE)


 


[THIS SECURITY IS A GLOBAL SECURITY WITHIN THE MEANING OF THE
INDENTURE HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME OF A DEPOSITARY OR A NOMINEE OF A DEPOSITARY. UNLESS AND UNTIL
IT IS EXCHANGED IN WHOLE OR IN PART FOR SECURITIES IN DEFINITIVE FORM IN ACCORDANCE WITH THE PROVISIONS OF THE INDENTURE AND THE
TERMS OF THE SECURITIES, TRANSFERS OF THIS GLOBAL SECURITY SHALL BE LIMITED TO TRANSFERS IN WHOLE, BUT NOT IN PART, TO THE DEPOSITORY
TRUST COMPANY, A NEW YORK CORPORATION (“DTC”), TO NOMINEES OF DTC OR TO A SUCCESSOR THEREOF OR SUCH SUCCESSOR’S
NOMINEE AND TRANSFERS OF PORTIONS OF THIS GLOBAL SECURITY SHALL BE LIMITED TO TRANSFERS MADE IN ACCORDANCE WITH THE RESTRICTIONS
SET FORTH IN THE INDENTURE REFERRED TO ON THE REVERSE HEREOF.


 


UNLESS THIS CERTIFICATE IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE
OF DTC, TO ABBVIE INC., OR ITS AGENT FOR REGISTRATION OF TRANSFER, EXCHANGE OR PAYMENT, AND ANY CERTIFICATE ISSUED IS REGISTERED
IN THE NAME OF CEDE & CO. OR IN SUCH OTHER NAME AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC (AND ANY PAYMENT IS
MADE TO CEDE & CO. OR TO SUCH OTHER ENTITY AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC), ANY TRANSFER, PLEDGE OR
OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL INASMUCH AS THE REGISTERED OWNER HEREOF, CEDE & CO.,
HAS AN INTEREST HEREIN.](1)


 


THIS SECURITY HAS NOT BEEN REGISTERED UNDER THE SECURITIES ACT
OF 1933, AS AMENDED (THE “SECURITIES ACT”), OR THE SECURITIES LAWS OF ANY STATE OR OTHER JURISDICTION.


 






    A-10-1


     


    

 


NEITHER THIS SECURITY NOR ANY INTEREST OR PARTICIPATION
HEREIN MAY BE REOFFERED, SOLD, ASSIGNED, TRANSFERRED, PLEDGED, ENCUMBERED OR OTHERWISE DISPOSED OF IN THE ABSENCE OF SUCH
REGISTRATION OR UNLESS SUCH TRANSACTION IS EXEMPT FROM, OR NOT SUBJECT TO, SUCH REGISTRATION. THE HOLDER OF THIS SECURITY, BY
ITS ACCEPTANCE HEREOF, AGREES ON ITS OWN BEHALF AND ON BEHALF OF ANY INVESTOR ACCOUNT FOR WHICH IT HAS PURCHASED SECURITIES,
TO OFFER, SELL OR OTHERWISE TRANSFER SUCH SECURITY, PRIOR TO THE DATE (THE “RESALE RESTRICTION TERMINATION DATE”)
THAT IS [IN THE CASE OF RULE 144A NOTES: ONE YEAR] [IN THE CASE OF REGULATION S NOTES: 40 DAYS] AFTER THE LATER OF THE ISSUE
DATE HEREOF OR ANY OTHER ISSUE DATE IN RESPECT OF A FURTHER ISSUANCE OF SECURITIES OF THE SAME SERIES AND THE LAST DATE ON
WHICH ABBVIE INC. OR ANY AFFILIATE OF ABBVIE INC. WAS THE OWNER OF THIS SECURITY (OR ANY PREDECESSOR OF SUCH SECURITY), ONLY
(A) TO ABBVIE INC. OR ANY SUBSIDIARY THEREOF, (B) PURSUANT TO A REGISTRATION STATEMENT THAT HAS BEEN DECLARED
EFFECTIVE UNDER THE SECURITIES ACT, (C) FOR SO LONG AS THE SECURITIES ARE ELIGIBLE FOR RESALE PURSUANT TO RULE 144A
UNDER THE SECURITIES ACT (“RULE 144A”), TO A PERSON IT REASONABLY BELIEVES IS A ‘‘QUALIFIED
INSTITUTIONAL BUYER’’ AS DEFINED IN RULE 144A THAT PURCHASES FOR ITS OWN ACCOUNT OR FOR THE ACCOUNT OF A
QUALIFIED INSTITUTIONAL BUYER TO WHOM NOTICE IS GIVEN THAT THE TRANSFER IS BEING MADE IN RELIANCE ON RULE 144A IN A
TRANSACTION MEETING THE REQUIREMENTS OF RULE 144A, (D) PURSUANT TO OFFERS AND SALES TO NON-U.S. PERSONS THAT OCCUR
OUTSIDE THE UNITED STATES WITHIN THE MEANING OF REGULATION S UNDER THE SECURITIES ACT, (E) TO AN INSTITUTIONAL
 “ACCREDITED INVESTOR” WITHIN THE MEANING OF RULE 501(a)(1), (2), (3) OR (7) UNDER THE SECURITIES ACT THAT IS
NOT A QUALIFIED INSTITUTIONAL BUYER AND THAT IS PURCHASING FOR ITS OWN ACCOUNT OR FOR THE ACCOUNT OF ANOTHER INSTITUTIONAL
ACCREDITED INVESTOR, IN EACH CASE IN A MINIMUM PRINCIPAL AMOUNT OF THE SECURITIES OF $250,000, FOR INVESTMENT PURPOSES AND
NOT WITH A VIEW TO OR FOR OFFER OR SALE IN CONNECTION WITH ANY DISTRIBUTION IN VIOLATION OF THE SECURITIES ACT
OR (F) PURSUANT TO ANOTHER AVAILABLE EXEMPTION FROM THE REGISTRATION REQUIREMENTS OF THE SECURITIES ACT, SUBJECT TO
ABBVIE INC.’S AND THE TRUSTEE’S RIGHT PRIOR TO ANY SUCH OFFER, SALE OR TRANSFER PURSUANT TO CLAUSES (D), (E)
OR (F) TO REQUIRE THE DELIVERY OF AN OPINION OF COUNSEL, CERTIFICATION AND/OR OTHER INFORMATION SATISFACTORY TO EACH OF
THEM.


 


[EACH PURCHASER OF THIS SECURITY IS HEREBY NOTIFIED THAT THE
SELLER OF THIS SECURITY MAY BE RELYING ON THE EXEMPTION FROM THE PROVISIONS OF SECTION 5 OF THE SECURITIES ACT PROVIDED BY
RULE 144A THEREUNDER.](2)


 


[BY ITS ACQUISITION HEREOF, THE HOLDER HEREOF REPRESENTS THAT
IT IS NOT A U.S. PERSON NOR IS IT PURCHASING FOR THE ACCOUNT OF A U.S. PERSON AND IS ACQUIRING THIS SECURITY IN AN OFFSHORE TRANSACTION
IN ACCORDANCE WITH REGULATION S UNDER THE SECURITIES ACT.](3)


 


[IN CONNECTION WITH ANY TRANSFER, THE HOLDER WILL DELIVER TO
THE REGISTRAR AND TRANSFER AGENT SUCH CERTIFICATES AND OTHER INFORMATION AS SUCH TRANSFER AGENT MAY REASONABLY REQUIRE TO CONFIRM
THAT THE TRANSFER COMPLIES WITH THE FOREGOING RESTRICTIONS.](4)


 


(1) Applies to Global Notes only


 


(2) Applies to Rule 144A Notes only


 


(3) Applies to Regulation S Notes only


 


(4) Applies to Notes in definitive form
only


 






    A-10-2


     


    

 


ABBVIE INC.


 


4.250% Senior Notes due 2049


 


	No. [●]	$[●]


 


CUSIP No: [●]


 


ISIN No: [●]


 


ABBVIE INC., a corporation duly organized
and existing under the laws of Delaware (herein called the “Company,” which term includes any successor Person
under the Indenture and Supplemental Indenture hereinafter referred to), for value received, hereby promises to pay to Cede &
Co., as nominee for The Depository Trust Company, or registered assigns, the principal sum of [●] Dollars ($[●]), or
such other principal sum as may be indicated on the Schedule of Exchanges attached hereto, on November 21, 2049, and to pay interest
thereon from November 21, 2019 or from the most recent Interest Payment Date to which interest has been paid or duly provided for,
semi-annually in arrears on May 21 and November 21 of each year, commencing on May 21, 2020, at the rate of 4.250% per annum, until
the principal hereof is paid or made available for payment. The interest so payable, and punctually paid or duly provided for,
on any Interest Payment Date will, as provided in such Indenture, be paid to the Person in whose name this Security (or one or
more Predecessor Securities) is registered at the close of business on the Regular Record Date for such interest, which shall be
the date that is 15 calendar days prior to the relevant Interest Payment Date (whether or not a Business Day). Any such interest
not so punctually paid or duly provided for will forthwith cease to be payable to the Holder on such Regular Record Date and may
either be paid to the Person in whose name this Security (or one or more Predecessor Securities) is registered at the close of
business on a Special Record Date for the payment of such Defaulted Interest to be fixed by the Trustee, notice whereof shall be
given to Holders of Securities of this series not less than 10 days prior to such Special Record Date, or be paid at any time in
any other lawful manner not inconsistent with the requirements of any securities exchange on which the Securities of this series
may be listed, and upon such notice as may be required by such exchange, all as more fully provided in said Indenture.


 


Payment of the principal of (and premium,
if any) and any such interest on this Security will be made at the office or agency of the Company maintained for that purpose
in St. Paul, Minnesota, in such coin or currency of the United States of America as at the time of payment is legal tender for
payment of public and private debts; provided, however, that at the option of the Company payment of interest may be made by (1) check
mailed to the address of the Person entitled thereto as such address shall appear in the Security Register or (2) wire transfer
as directed by the Holder, in immediately available funds to an account maintained by the Depository or its nominee with respect
to a Global Note, and to the Holder or its nominee with respect to a Definitive Note; provided further that in the case of a Definitive
Note (1) the Holder thereof shall have provided written wiring instructions to the Trustee on or before the related Regular
Record Date and (2) if appropriate instructions for any such wire transfer are not received by the related Regular Record
Date, then such payment shall be made by check mailed to the address of the Holder specified in the Security Register.


 






    A-10-3


     


    

 


Reference is hereby made to the further
provisions of this Security set forth on the reverse hereof, which further provisions shall for all purposes have the same effect
as if set forth at this place.


 


Unless the certificate of authentication
hereon has been executed by the Trustee referred to herein by manual signature, this Security shall not be entitled to any benefit
under the Indenture or be valid or obligatory for any purpose.


 






    A-10-4


     


    

 


IN WITNESS WHEREOF, the Company has caused
this instrument to be duly executed.


 


	Dated: November 21, 2019	
	 	 
	 	ABBVIE INC.
	 	 
	 	By:	 
	 	 	Name:
	 	 	Title:




 






    A-10-5


     


    

 


TRUSTEE’S CERTIFICATE OF AUTHENTICATION


 


This is one of the Securities of the series
designated therein referred to in the within-mentioned Indenture.


 


	Dated: November 21, 2019	
	 	 
	 	U.S. BANK NATIONAL ASSOCIATION,

    as Trustee
	 	 
	 	By:	 
	 	 	Authorized Signatory



 






    A-10-6


     


    

 


[FORM OF REVERSE OF SECURITY]


 


This Security is one of a duly authorized
issue of securities of the Company (herein called the “Securities”), issued and to be issued in one or more
series under an Indenture, dated as of November 8, 2012, as it may be supplemented or amended from time to time (herein called
the “Indenture”), between the Company and U.S. Bank National Association, as Trustee (herein called the “Trustee,”
which term includes any successor trustee under the Indenture), and Supplemental Indenture No. 7, dated as of November 21,
2019 (herein called the “Supplemental Indenture”), between the Company and the Trustee, to which Indenture,
Supplemental Indenture and all indentures supplemental thereto reference is hereby made for a statement of the respective rights,
limitations of rights, duties and immunities thereunder of the Company, the Trustee and the Holders of the Securities of this series
and of the terms upon which the Securities of this series are, and are to be, authenticated and delivered. This Security is one
of the series designated on the face hereof, in an initial aggregate principal amount of $[●].


 


Optional Redemption 


 


At any time prior to the Par Call Date (as
defined below), the Company may redeem some or all of the Securities of this series at its option, in each case at a redemption
price equal to the greater of: (i) 100% of the principal amount of the Securities of this series to be redeemed; and (ii) the sum
of the present values of the remaining scheduled payments (through the Par Call Date assuming for such purpose that such Securities
matured on the Par Call Date) of principal and interest on the Securities of this series to be redeemed (exclusive of interest
accrued to the Redemption Date) discounted to the Redemption Date on a semiannual basis (assuming a 360-day year consisting of
twelve 30-day months) at the then current Treasury Rate plus 30 basis points.


 


The Company will pay accrued and unpaid
interest on the principal amount of the Securities of this series being redeemed to, but excluding, the Redemption Date.


 


In addition, at any time on or after the
Par Call Date, the Company may redeem some or all of the Securities of this series at its option at a redemption price equal to
100% of the principal amount of the Securities of this series to be redeemed, plus accrued and unpaid interest on the principal
amount of Securities of this series being redeemed to, but excluding, the Redemption Date.


 


If the Company has given notice as provided
in the Indenture and funds for the redemption of any Securities of this series called for redemption have been made available on
the Redemption Date in accordance with the Indenture, such Securities will cease to bear interest on the date fixed for redemption.
Thereafter, the only right of the Holders of such Securities will be to receive payment of the redemption price.


 


The Company will give notice of any
optional redemption, electronically or by mail, to Holders at their addresses, as shown in the Security Register for such
Securities, or as otherwise in accordance with the applicable procedures of DTC, not more than 60 nor less than 15 days prior
to the date fixed for redemption. The notice of redemption will specify, among other items, the Redemption Date, redemption
price, the principal amount of the Securities of this series to be redeemed and the place or places that payment will be made
upon surrender of the Securities of this series to be redeemed. Any redemption or notice of redemption may, at the
Company’s discretion, be subject to one or more conditions precedent, and, at the Company’s discretion, the
redemption date may be delayed until such time as any or all such conditions shall be satisfied. The Company shall provide
written notice to the Trustee prior to the close of business two Business Days prior to the redemption date if any such
redemption has been rescinded or delayed, and upon receipt the Trustee shall provide such notice to each holder of the
Securities in the same manner in which the notice of redemption was given.


 






    A-10-7


     


    

 


The Company will notify the Trustee at least
30 days prior to the Redemption Date fixed by the Company (or such shorter period as is satisfactory to the Trustee) of the aggregate
principal amount of the Securities of this series to be redeemed and their Redemption Date. If less than all of the Securities
of this series are to be redeemed at any time, the Trustee shall select, not more than 30 days prior to the Redemption Date, which
Securities or the portion thereof, that are to be redeemed from the outstanding Securities of this series not previously redeemed
by random lot.


 


“Comparable Treasury Issue”
means the United States Treasury security selected by the Independent Investment Banker as having a maturity comparable to the
remaining term (assuming, for this purpose, that the Securities matured on the Par Call Date) (“Remaining Life”) of
the Securities of this series to be redeemed that would be utilized, at the time of selection and in accordance with customary
financial practice, in pricing new issues of corporate debt securities of comparable maturity to the Remaining Life of such Securities
(assuming, for this purpose, that the Securities matured on the Par Call Date).


 


“Comparable Treasury Price”
means, with respect to any Redemption Date, (1) if the Company obtains four or more Reference Treasury Dealer Quotations for
such Redemption Date, the average of such Reference Treasury Dealer Quotations, after excluding the highest and lowest Reference
Treasury Dealer Quotations, or (2) if the Company obtains fewer than four such Reference Treasury Dealer Quotations, the average
of all such quotations.


 


“Independent Investment Banker”
means one of the Reference Treasury Dealers that the Company appoints to act as the Independent Investment Banker from time to
time.


 


“Business Day” means
any calendar day that is not a Saturday, Sunday or legal holiday in New York, New York and on which commercial banks are open for
business in New York, New York.


 


“Par Call Date” means
May 21, 2049 (six months prior to the maturity date of the Securities of this series).


 


“Primary Treasury Dealer”
means a primary United States government securities dealer in the United States of America.


 


“Reference Treasury
Dealer” means (i) each of Morgan Stanley & Co. LLC, BofA Securities, Inc., Barclays Capital Inc. and
any of their respective successors; provided, however, that if any of them ceases to be a Primary Treasury Dealer, the
Company will substitute therefor another Primary Treasury Dealer and (ii) any other Primary Treasury Dealers the Company
selects.


 


“Reference Treasury Dealer Quotations”
means, with respect to each Reference Treasury Dealer and any Redemption Date, the average, as determined by the Company, of the
bid and asked prices for the Comparable Treasury Issue (expressed in each case as a percentage of its principal amount) quoted
in writing to the Company by such Reference Treasury Dealer at 3:30 p.m., New York City time, on the third Business Day preceding
such Redemption Date.


 






    A-10-8


     


    

 


“Treasury Rate” means,
with respect to any Redemption Date, (1) the rate per annum equal to the yield, under the heading which represents the average
for the immediately preceding week, appearing in the most recently published statistical release designated “H.15(519)”
or any successor publication which is published weekly by the Board of Governors of the Federal Reserve System and which establishes
yields on actively traded United States Treasury securities adjusted to constant maturity under the caption “Treasury Constant
Maturities” for the maturity corresponding to the Comparable Treasury Issue; provided that, if no maturity is within three
months before or after the Remaining Life of the Securities of this series to be redeemed, yields for the two published maturities
most closely corresponding to the Comparable Treasury Issue shall be determined and the Treasury Rate shall be interpolated or
extrapolated from those yields on a straight line basis, rounding to the nearest month; or (2) if such release (or any successor
release) is not published during the week preceding the calculation date or does not contain such yields, the rate per year equal
to the semiannual equivalent yield to maturity of the Comparable Treasury Issue, calculated using a price for the Comparable Treasury
Issue (expressed as a percentage of its principal amount) equal to the Comparable Treasury Price for such Redemption Date. The
Treasury Rate shall be calculated on the third Business Day preceding the Redemption Date.


 


Special Mandatory Redemption 


 


If (i)
the consummation of the Acquisition (as defined below) does not occur on or before January 30, 2021 or (ii) the Company notifies
the Trustee that the Company will not pursue the consummation of the Acquisition (each of (i) and (ii), a “Special Mandatory
Redemption Trigger”), the Company will be required to redeem the Securities of this series then outstanding (such redemption,
the “Special Mandatory Redemption”) at a redemption price equal to 101% of the principal amount of such Securities
plus accrued and unpaid interest, if any, to, but not including, the Special Mandatory Redemption Date (the “Special Mandatory
Redemption Price”). The “Acquisition” means the acquisition by the Company of Allergan plc and its
subsidiaries pursuant to the definitive transaction agreement, dated as of June 25, 2019, by and among the Company, Venice Subsidiary
LLC, a Delaware limited liability company and a direct wholly owned subsidiary of the Company, and Allergan plc, as amended from
time to time.


 


In
the event that the Company becomes obligated to redeem the Securities of this series pursuant to the Special Mandatory
Redemption, the Company will promptly, and in any event not more than five Business Days after the date on which a Special
Mandatory Redemption Trigger occurred, deliver notice to the Trustee of the Special Mandatory Redemption and the date upon
which the Securities of this series will be redeemed (the “Special Mandatory Redemption Date,” which date
shall be no later than the third Business Day following the date of such notice) together with a notice of Special
Mandatory Redemption for the Trustee to deliver to each registered holder of the Securities of this series to be redeemed.
The Trustee will then promptly mail, or electronically deliver, according to the procedures of DTC, such notice of Special
Mandatory Redemption to each registered holder of the Securities of this series to be redeemed. Unless the Company defaults
in payment of the Special Mandatory Redemption Price, on and after such Special Mandatory Redemption Date, interest will
cease to accrue on the Securities of this series to be redeemed.


 






    A-10-9


     


    

 


Failure to comply in any material respect
with any obligations in the provisions described under this caption “Special Mandatory Redemption” shall constitute
an “Event of Default” under Section 5.1(7) of the Indenture.


 


Notwithstanding the foregoing, installments
of interest on the Securities of this series that are due and payable on Interest Payment Dates falling on or prior to the Special
Mandatory Redemption Date will be payable on such Interest Payment Dates to the Holder as of the close of business on the relevant
Record Dates in accordance with the Securities of this series and the Indenture.


 


For the avoidance of doubt, Article Eleven of the Indenture
shall not apply to the Special Mandatory Redemption.


 


Sinking Fund 


 


The Securities of this series do not provide
for a sinking fund.


 


Default 


 


If an Event of Default with respect to Securities
of this series shall occur and be continuing, the principal of the Securities of this series may be declared due and payable in
the manner and with the effect provided in the Indenture.


 


Miscellaneous


 


The Indenture contains provisions for defeasance
at any time of the entire indebtedness of this Security or certain restrictive covenants and Events of Default with respect to
this Security, in each case upon compliance with certain conditions set forth therein. Sections 13.2 and 13.3 of the Indenture
apply to the Securities of this series.


 


The Indenture permits, with certain
exceptions as therein provided, the amendment thereof and the modification of the rights and obligations of the Company and
the rights of the Holders of the Securities of each series to be affected under the Indenture at any time by the Company and
the Trustee with the consent of the Holders of not less than a majority in principal amount of the Securities at the time
Outstanding of each series to be affected. The Indenture also contains provisions permitting the Holders of specified
percentages in principal amount of the Securities at the time Outstanding of any series, on behalf of the Holders of all
Securities of such series, to waive compliance by the Company with certain provisions of the Indenture and certain past
defaults under the Indenture and their consequences. Any such consent or waiver by the Holder of this Security shall be
conclusive and binding upon such Holder and upon all future Holders of this Security and of any Security issued upon the
registration of transfer hereof or in exchange herefor or in lieu hereof, whether or not notation of such consent or waiver
is made upon this Security.


 






    A-10-10


     


    

 


No reference herein to the Indenture or
Supplemental Indenture and no provision of this Security or of the Indenture or Supplemental Indenture shall alter or impair the
obligation of the Company, which is absolute and unconditional, to pay the principal of and any premium and interest on this Security
at the times, place and rate, and in the coin or currency, herein prescribed.


 


As provided in the Indenture and subject
to certain limitations therein set forth, the transfer of this Security is registerable in the Security Register, upon surrender
of this Security for registration of transfer at the office or agency of the Company in any place where the principal of and any
premium and interest on this Security are payable, duly endorsed by, or accompanied by a written instrument of transfer in form
satisfactory to the Company and the Security Registrar duly executed by, the Holder hereof or his attorney duly authorized in writing,
and thereupon one or more new Securities of this series and of like tenor, of authorized denominations and for the same aggregate
principal amount, will be issued to the designated transferee or transferees.


 


The Securities of this series are issuable
only in registered form without coupons in denominations of $2,000 and any integral multiple of $1,000 in excess thereof. As provided
in the Indenture and subject to certain limitations therein set forth, Securities of this series are exchangeable for a like aggregate
principal amount of Securities of this series and of like tenor of a different authorized denomination, as requested by the Holder
surrendering the same.


 


No service charge shall be made for any
registration of transfer or exchange of the Notes, but the Company or the Security Registrar may require payment of a sum sufficient
to cover any transfer tax, assessments, or similar governmental charge payable in connection therewith (other than any such transfer
taxes, assessments or similar governmental charge payable upon exchange or transfer pursuant to Sections 9.6 or 11.7 of the Indenture).


 


Prior to due presentment of this Security
for registration of transfer, the Company, the Trustee and any agent of the Company or the Trustee will treat the Person in whose
name this Security is registered as the owner hereof for the purpose of receiving payments and for all other purposes, whether
or not this Security be overdue, and neither the Company, the Trustee nor any such agent shall be affected by notice to the contrary.


 


All terms used in this Security which are
defined in the Indenture and Supplemental Indenture shall have the meanings assigned to them in the Indenture and Supplemental
Indenture.


 


THIS SECURITY SHALL BE GOVERNED BY AND CONSTRUED
IN ACCORDANCE WITH THE LAWS OF THE STATE OF NEW YORK.


 


This Security is a Book-Entry
Security within the meaning of the Indenture hereinafter referred to and is registered in the name of a Depository or a
nominee of a Depository. This Security is exchangeable for Securities registered in the name of a person other than the
Depository or its nominee only in the limited circumstances described in the Indenture and may not be transferred except as a
whole by the Depository to a nominee of the Depository or by a nominee of the Depository to the Depository or another nominee
of the Depository.


 


*                                        
*                                        
*







    A-10-11


     


    

 


SCHEDULE OF EXCHANGES


 


The following exchanges, redemptions or
purchases of a part of this Book-Entry Security have been made:


 


	Date of

Exchange/

Redemption/

Repurchase	Amount of

decrease in

Principal Amount

of this Book-

Entry

Security	Amount of

increase in

Principal Amount

of this Book-

Entry Security	Principal Amount

of this Book-

Entry

Security following

such decrease (or

increase)	Signature of

authorized

signatory of

Trustee
	 	 	 	 	 
	 	 	 	 	 
	 	 	 	 	 



 






    A-10-12


     


    

 


ASSIGNMENT FORM


 


To assign this Security, fill in the form below:


 


I or we assign and transfer this Security to


 


 


	(Print or type assignee’s name, address and zip code)


 


 


	(Insert assignee’s soc. sec. or tax I.D. No.)


 


and irrevocably appoint                               
as agent to transfer this Security on the books of the Company. The agent may substitute another to act for him.


 


 


Date:


 


Your Signature*:


 


By:


 


Name:


 


Title:


 


 


Sign exactly as your name appears on the
other side of this Security.


 


 


 


*Signature Guaranteed:


 


 


*NOTICE: The signature to this assignment must correspond with
the name as it appears upon the face of the within Note in every particular, without alteration, enlargement or any change whatever.
Such signature must be guaranteed by an “eligible guarantor institution” meeting the requirements of the Security Registrar,
which requirements include membership or participation in Security Transfer Agents Medallion Program (“STAMP”) or such
other “signature guarantee program” as may be determined by the Security Registrar in addition to, or in substitution
for, STAMP, all in accordance with the Securities Exchange Act of 1934, as amended.







    A-10-13


     


    

 


FORM OF TRANSFER CERTIFICATE


 


In connection with any transfer of any of
the Securities evidenced by this certificate occurring prior to the expiration of the period referred to in Rule 144 under
the Securities Act (“Rule 144”) after the later of the date of original issuance of such Notes and the last date,
if any, on which such Notes were owned by the Company or any Affiliate (as such term is defined in Rule 144) of the Company,
the undersigned confirms that such Securities are being transferred in accordance with its terms:


 


CHECK
ONE BOX BELOW


 


		(1)	 ̈ to the Company; or



 


		(2)	 ̈ pursuant to an effective registration
                                                            statement under the Securities Act; or



 


		(3)	 ̈ inside the United States to a person reasonably believed to be a
                                                            “qualified institutional buyer” (as defined in Rule 144A under the Securities Act) that purchases for its own
                                                            account or for the account of a qualified institutional buyer to whom notice is given that such transfer is being made in
                                                            reliance on Rule 144A, in each case pursuant to and in compliance with Rule 144A under the Securities Act; or



 


		(4)	 ̈ in an offshore transaction in compliance with Rule 903 or Rule 904
                                                            of Regulation S under the Securities Act; or



 


		(5)	 ̈ pursuant to the exemption from registration provided by Rule 144
                                                            under the Securities Act or any other available exemption from the registration requirement of the Securities Act.



 


Unless one of the boxes is checked,
the Trustee shall refuse to register any of the Securities evidenced by this certificate in the name of any person other than the
registered holder thereof; provided, however, that if box (5) is checked, the Trustee shall be entitled to require, prior
to registering any such transfer of the Securities, such legal opinions, certifications and other information as the Company has
reasonably requested to confirm that such transfer is being made pursuant to an exemption from, or in a transaction not subject
to, the registration requirements of the Securities Act.


 


	 	Signature




 






    A-10-14


     


    

 


TO BE COMPLETED
BY PURCHASER IF (3) ABOVE IS CHECKED.


 


The undersigned represents and warrants that it is purchasing
this Security for its own account or an account with respect to which it exercises sole investment discretion and that it and any
such account is a “qualified institutional buyer” within the meaning of Rule 144A under the Securities Act, and is
aware that the sale to it is being made in reliance on Rule 144A and acknowledges that it has received such information regarding
the Company as the undersigned has requested pursuant to Rule 144A or has determined not to request such information and that it
is aware that the transferor is relying upon the undersigned’s foregoing representations in order to claim the exemption
from registration provided by Rule 144A.


 


		Dated:____________________	Notice: To be executed by an executive officer



 






    A-10-15


     


    

 


FORM OF EXCHANGE CERTIFICATE


 


AbbVie Inc.


1 North Waukegan Road


North Chicago, Illinois 60064


 


U.S. Bank National Association


190 South LaSalle Street, 10th Floor


Chicago, IL 60603


Attention: Corporate Trust Services


 


Re: 4.250% Senior Notes due
2049


 


Reference is hereby made to the Indenture,
dated as of November 8, 2012 (the “Base Indenture”), as supplemented by the First Supplemental Indenture, dated as
of November 8, 2012, the Second Supplemental Indenture, dated as of May 14, 2015, the Third Supplemental Indenture, dated as of
May 12, 2016, the Fourth Supplemental Indenture, dated as of November 17, 2016, the Fifth Supplemental Indenture, dated as of September
18, 2018, the Sixth Supplemental Indenture, dated as of September 26, 2019 and the Seventh Supplemental Indenture, dated as of
November 21, 2019 (as so supplemented, the “Indenture”), between AbbVie Inc. (the “Company”) and U.S. Bank
National Association, a national banking association as trustee. Capitalized terms used but not defined herein shall have the meanings
given to them in the Indenture.


 


___________ (the “Owner”) owns
and proposes to exchange the Security[ies] or interest in such Security[ies] specified herein, in the principal amount of $__________
in such Security[ies] or interests (the “Exchange”). In connection with the Exchange, the Owner hereby certifies that
in connection with the Exchange of the Owner’s Regulation S Global Note for a beneficial interest in the Rule 144A Global
Note, with an equal principal amount, the Security[ies] or interest in such Security[ies] specified herein [is][are] being transferred
to a Person (A) who the transferor reasonably believes to be a QIB, (B) purchasing for its own account or the account of a QIB
in a transaction meeting the requirements of Rule 144A, and (C) in accordance with all applicable securities laws of the States
of the United States and other jurisdictions.


 


This certificate and the statements contained
herein are made for your benefit and the benefit of the Company and are dated _________.


 


	 	[Insert Name of Transferor]
	 
	 	By:	 
	 	 	Name:
	 	 	Title:
	 
	Dated: _______________________:	 




 






    A-10-16


     


    

 





 



 


EXHIBIT B


 


FORM OF CERTIFICATE TO BE

DELIVERED IN CONNECTION WITH

TRANSFERS PURSUANT TO REGULATION S


 


[Date]


 


Attention:


 


		Re:	



 


AbbVie Inc. (the “Company”)

[applicable series of Notes] (the “Securities”)


 


Ladies and Gentlemen:


 


In connection with our proposed sale of
$                             aggregate
principal amount of the Securities, we confirm that such sale has been effected pursuant to and in accordance with
Regulation S under the U.S. Securities Act of 1933, as amended (the “Securities Act”), and, accordingly, we
represent that:


 


		(1)	the offer of the Securities was not made to a person in the United States;



 


		(2)	either (a) at the time the buy offer was originated, the transferee was outside the United States or we and any person acting
on our behalf reasonably believed that the transferee was outside the United States, or (b) the transaction was executed in, on
or through the facilities of a designated offshore securities market and neither we nor any person acting on our behalf knows that
the transaction has been prearranged with a buyer in the United States;



 


		(3)	no directed selling efforts have been made in the United States in contravention of the requirements of Rule 903 or Rule 904
of Regulation S, as applicable;



 


		(4)	the transaction is not part of a plan or scheme to evade the registration requirements of the Securities Act; and



 


		(5)	we have advised the transferee of the transfer restrictions applicable to the Securities.



 


You and the Company are entitled to rely upon this letter and
are irrevocably authorized to produce this letter or a copy hereof to any interested party in any administrative or legal proceedings
or official inquiry with respect to the matters covered hereby. Terms used in this certificate have the meanings set forth in Regulation S.


 






    B-1


     


    

 


	 	Very truly yours,
	 	 
	 	[Name of Transferor]
	 	 
	 	By:	 
	 	 
	 	Authorized Signature




 






    B-2


     


    

 


EXHIBIT C


 


FORM OF SUPPLEMENTAL INDENTURE

IN RESPECT OF THE GUARANTEES


 


THIS SUPPLEMENTAL INDENTURE NO.        ,
dated as of                           ,
20       (this “Supplemental Indenture”), among                            ,
a                                                       
(each, a “Guarantor”), AbbVie Inc. (the “Company”) and U.S. Bank National Association,
a national banking association, as trustee (the “Trustee”).


 


RECITALS


 


WHEREAS, the Company has heretofore executed
and delivered to the Trustee an Indenture, dated as of November 8, 2012 (the “Base Indenture” and, as heretofore
supplemented or amended, the “Indenture”), providing for the issuance from time to time of one or more series
of Securities (as defined in the Indenture);


 


WHEREAS, the Company has entered into a
definitive transaction agreement, dated as of June 25, 2019, by and among the Company, Allergan plc, an Irish public limited company
(“Allergan”), and Venice Subsidiary LLC, a wholly owned subsidiary of the Company (“Acquiror Sub”),
as amended from time to time, which provides, among other things, that on the terms and subject to the conditions set forth therein,
Acquiror Sub will acquire Allergan, with Allergan surviving as a wholly owned subsidiary of the Company (the “Acquisition”);


 


WHEREAS, Section 3.1 of Supplemental Indenture
No. 7, dated as of November 21, 2019 (“Supplemental Indenture No. 7”), provides that on the date that is 90
days after the closing date of the Acquisition, the punctual payment when due of all monetary obligations of the Company under
the Indenture (with respect to the Securities and the obligations to the Trustee under Section 6.7 of the Indenture) and the Securities,
whether for principal of or interest on the Securities, will be, jointly and severally, unconditionally guaranteed on an unsubordinated
unsecured basis by certain direct or indirect existing or future wholly-owned Subsidiaries of the Company;


 


WHEREAS, each Guarantor desires to enter
into such supplemental indenture for good and valuable consideration, including substantial economic benefit in that the financial
performance and condition of each Guarantor is dependent on the financial performance and condition of the Company, the obligations
hereunder each Guarantor is guaranteeing;


 


WHEREAS, the Company has expressed its intention
to fully and unconditionally guarantee the outstanding notes of, inter alia, certain indebtedness of Allergan and/or its
subsidiaries on an unsubordinated unsecured basis (the “AbbVie Guarantees”);


 


WHEREAS, pursuant to Section 9.1 of
the Base Indenture, the parties hereto are authorized to execute and deliver this Supplemental Indenture to amend the Indenture,
without the consent of any Holder of the Securities;


 


WHEREAS, each Guarantor and the Company
have requested that the Trustee execute and deliver this Supplemental Indenture; and


 






    C-1


     


    

 


WHEREAS, all the conditions and requirements
necessary to make this Supplemental Indenture, when duly executed an delivered, a valid and binding agreement in accordance with
its terms and for the purposes herein expressed, have been performed and fulfilled.


 


NOW, THEREFORE, THIS SUPPLEMENTAL INDENTURE
WITNESSETH:


 


For and in consideration of the premises
provided for herein, each Guarantor, the Company and the Trustee mutually covenant and agree for the equal and proportionate benefit
of the Holders of the Securities as follows:


 


		1.	Definitions and Rules of Construction. For all purposes of this Supplemental Indenture:



 


		(a)	capitalized terms used herein without definition shall have the meanings specified in the Indenture;



 


		(b)	all references herein to Articles and Sections, unless otherwise specified, refer to the corresponding Articles and Sections
of this Supplemental Indenture;



 


		(c)	the terms “herein,” “hereof,” “hereunder” and other words of similar import refer to this
Supplemental Indenture; and



 


		(d)	in the event of a conflict with the definition of terms in the Indenture, the definitions in this Supplemental Indenture shall
control.



 


		2.	Guarantees.



 


		(a)	Each Guarantor, as primary obligor and not merely as surety, hereby unconditionally guarantees to each Holder of the Securities
and to the Trustee and its successor and assigns (the “Guarantees”) on an unsubordinated unsecured basis the
punctual payment when due of all monetary obligations of the Company under the Indenture (with respect to the Securities and the
obligations to the Trustee under Section 6.1 of the Base Indenture) and the Securities, whether for principal of or interest on
the Securities, on the terms and subject to the conditions set forth in this Supplemental Indenture and agrees to be bound by (and
shall be entitled to the benefits of) all other applicable provisions of the Indenture as a Guarantor.



 


		(b)	The obligations of each Guarantor shall be limited to the maximum amount as shall, after giving effect to all other contingent
and fixed liabilities of such Guarantor, result in the obligations of such Guarantor under the Guarantees not constituting a fraudulent
conveyance or fraudulent transfer under applicable law, or being void or unenforceable under any law relating to insolvency of
debtors.



 


		(c)	Each Guarantor further agrees that (to the fullest extent permitted by law) its obligations hereunder shall be
                                                             unconditional, irrespective of the validity, regularity or enforceability of the Indenture, the Securities or the obligations
                                                             of the Company hereunder or thereunder, the absence of any action to enforce the same, any waiver or consent by any Holder
                                                             with respect to any provisions hereof or thereof, the recovery of any judgment against the Company, any action to enforce the
                                                             same, or any other circumstance that might otherwise constitute a legal
or equitable discharge or defense of such Guarantor.



 






    C-2


     


    

 


		(d)	Each Guarantor hereby waives (to the fullest extent permitted by law) the benefit of diligence, presentment, demand of payment,
filing of claims with a court in the event of insolvency or bankruptcy of the Company, any right to require a proceeding first
against the Company, protest, notice and all demands whatsoever and covenants that (except as otherwise provided in Section 3
hereof) its Guarantees shall not be discharged except by complete performance of the obligations contained in the Securities, the
Indenture and the Guarantees. The Guarantees are a guarantee of payment and not of collection.



 


		(e)	The Guarantees shall be continuing Guarantees and shall, subject to Section 3 hereof, (i) remain in full force and
effect until payment in full of the principal amount of all of the Notes (as defined in Supplemental Indenture No. 7) and the Existing
AbbVie Notes (whether by payment at maturity, purchase, redemption, defeasance, retirement or other acquisition), (ii) be
binding upon each Guarantor and (iii) inure to the benefit of and be enforceable by the Trustee, the Holders of Securities
and their permitted successors, transferees and assigns.



 


		(f)	The obligations of each Guarantor hereunder shall continue to be effective or shall be reinstated, as the case may be, if at
any time any payment which would otherwise have reduced or terminated the obligations of such Guarantor hereunder and under the
Guarantees (whether such payment shall have been made by or on behalf of the Company or by or on behalf of such Guarantor) is rescinded
or reclaimed from any of the Holders upon the insolvency, bankruptcy, liquidation or reorganization of the Company or such Guarantor
or otherwise, all as though such payment had not been made.



 


		3.	Termination, Release and Discharge.



 


		(a)	Each Guarantor will be automatically and unconditionally released from its obligations under the Indenture and with respect
to the Guarantees:



 


		(i)	with respect to any series of Securities, as applicable, if AbbVie exercises its legal defeasance option or covenant defeasance
option as described in Sections 13.1, 13.2 and 13.3 of the Indenture with respect to such series of Securities or if the Company’s
obligations under the Indenture are discharged in accordance with the terms of the Indenture in respect of such series of Securities;



 


		(ii)	with respect to all series of Securities, on the date upon which such Guarantor (or any successor entity thereto) ceases to
be a Subsidiary of the Company;



 






    C-3


     


    

 


		(iii)	with respect to all series of Securities, on the date
upon which such Guarantor (or any successor entity thereto) ceases to guarantee: (A) any Borrowed Debt of Allergan or any of its
Subsidiaries (other than the Specified Allergan Debt and other than any intercompany Borrowed Debt owed to another member of the
Consolidated Group) in an aggregate principal amount that exceeds $3,000,000,000; and (B) (x) AbbVie’s obligations
under the Existing Credit Agreement, (y) AbbVie’s obligations under the Existing AbbVie Notes and/or (z) AbbVie’s obligations
under any other Borrowed Debt (other than the Notes (as defined in Supplemental Indenture No. 7), the Exchange Notes and any other
intercompany Borrowed Debt owed to another member of the Consolidated Group) that is outstanding for clauses (x) - (z) in an aggregate
committed (with respect to clause (x) above) and principal (with respect to clauses (y) and (z) above) amount of at least $2,000,000,000;
or (iv) if the AbbVie Guarantees are released for any reason.



 


		(b)	At the request of the Company, and upon delivery to the Trustee of an Officers’ Certificate and an Opinion of Counsel,
each stating that all conditions precedent under the Indenture relating to such release have been complied with, the Trustee will
execute any documents reasonably requested by the Company evidencing such release.



 


		(c)	If a Guarantor is released from its obligations hereunder pursuant to this section, it shall cease to be a “Guarantor”
as defined in and for purposes hereof.



 


		4.	Notation Not Required. Neither the Company nor a Guarantor shall be required to make a notation on the Securities to
reflect the Guarantees or any release thereof.



 


		5.	Waiver of Subrogation. Each Guarantor hereby irrevocably waives any claim or other rights which it may now or hereafter
acquire against the Company that arise from the existence, payment, performance or enforcement of such Guarantor’s obligations
under the Guarantees and the Indenture, including, without limitation, any right of subrogation, reimbursement, exoneration, indemnification,
and any right to participate in any claim or remedy of any Holder of Securities against the Company, whether or not such claim,
remedy or right arises in equity, or under contract, statute or common law, including, without limitation, the right to take or
receive from the Company, directly or indirectly, in cash or other property or by set-off or in any other manner, payment or security
on account of such claim or other rights in relation to the Trustee until all monetary obligations of the Company under the Indenture
and the Securities, whether for principal of or interest on the Securities, are paid in full. If any amount shall be paid to a
Guarantor in violation of the preceding sentence and the Securities shall not have been paid in full, such amount shall have been
deemed to have been paid to a Guarantor for the benefit of, and held in trust for the benefit of, the Holders of the Securities,
and shall forthwith be paid to the Trustee for the benefit of such Holders to be credited and applied upon the Securities, whether
matured or unmatured, in accordance with the terms of the Indenture. Each Guarantor acknowledges that it will receive direct and
indirect benefits from the financing arrangements contemplated by this Supplemental Indenture and that the waiver set forth in
this section is knowingly made in contemplation of such benefits.



 


		6.	Parties. Nothing in this Supplemental Indenture is intended or shall be construed to give any Person, other than the
Holders of the Securities and the Trustee, any legal or equitable right, remedy or claim under or with respect to a Guarantor’s
Guarantee or any provision contained herein or in Article Three of the Supplemental Indenture No. 7.



 






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		7.	Governing Law. This Supplemental Indenture shall be governed by and construed in accordance with the laws of the State
of New York.



 


		8.	Adoption, Ratification and Confirmation. The Indenture, as supplemented and amended by this Supplemental Indenture,
is in all respects hereby adopted, ratified and confirmed, and this Supplemental Indenture shall be deemed part of the Indenture
in the manner and to the extent herein and therein provided.



 


		9.	Trustee Not Responsible for Recitals. The recitals contained herein and in the Securities, except the Trustee’s
certificates of authentication, shall be taken as the statements of the Company, and the Trustee assumes no responsibility for
their correctness.  The Trustee makes no representations as to the validity or sufficiency of this Supplemental Indenture
or of the Securities.



 


		10.	Counterparts. This Supplemental Indenture may be executed in any number of counterparts, each of which when so executed
shall be deemed an original, and all such counterparts shall together constitute but one and the same instrument.



 


		11.	Notices. Notice to a Guarantor shall be sufficient if addressed to such Guarantor care of the Company at the address,
place and manner provided in Section 1.5 of the Base Indenture.



 


		13.	Integral Part; Effect of Supplement on Indenture. This Supplemental Indenture constitutes an integral part of the Base
Indenture. Except for the amendments and supplements made by this Supplemental Indenture, the Base Indenture shall remain in full
force and effect as executed.



 


		14.	Separability. In case any one or more of the provisions contained in this Supplemental Indenture or in the Securities
shall for any reason be held to be invalid, illegal or unenforceable in any respect, such invalidity, illegality or unenforceability
shall not affect any other provisions of this Supplemental Indenture or of the Securities, but this Supplemental Indenture and
the Securities shall be construed as if such invalid or illegal or unenforceable provision had never been contained herein or therein.



 






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IN WITNESS WHEREOF,
the parties hereto have caused this Supplemental Indenture to be duly executed as of the date first above written.


 


 


	 	By:
	 	 	Name:
	 	 	Title:
	 	 
	 	 
	 	ABBVIE INC.
	 	 
	 	By:
	 	 	Name:
	 	 	Title:
	 	 
	 	 
	 	U.S.
                                         BANK NATIONAL ASSOCIATION

                                                                     as
                                         Trustee

	 	 
	 	By:
	 	 	Name:
	 	 	Title:




 






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