Exhibit 4.1

  

  

  

  
    CONTINGENT VALUE RIGHTS AGREEMENT

     

    by and between

     

    BRISTOL-MYERS SQUIBB COMPANY

     

    and

     

    EQUINITI TRUST COMPANY

     

    Dated as of [______], [____]

     

    
      
        


    

    
    TABLE OF CONTENTS

     

    	
            ARTICLE 1 DEFINITIONS AND OTHER PROVISIONS OF GENERAL APPLICATION

          	
            1

          
	 	
            Section 1.1

          	
            Definitions

          	
            1

          
	 	
            Section 1.2

          	
            Compliance and Opinions

          	
            8

          
	 	
            Section 1.3

          	
            Form of Documents Delivered to Trustee

          	
            9

          
	 	
            Section 1.4

          	
            Acts of Holders

          	
            9

          
	 	
            Section 1.5

          	
            Notices, etc., to Trustee and Company

          	
            10

          
	 	
            Section 1.6

          	
            Notice to Holders; Waiver.

          	
            11

          
	 	
            Section 1.7

          	
            Conflict with Trust Indenture Act

          	
            11

          
	 	
            Section 1.8

          	
            Effect of Headings and Table of Contents

          	
            11

          
	 	
            Section 1.9

          	
            Benefits of Agreement

          	12
	 	
            Section 1.10

          	
            Governing Law

          	
            12

          
	 	
            Section 1.11

          	
            Legal Holidays

          	
            12

          
	 	
            Section 1.12

          	
            Separability Clause

          	
            12

          
	 	
            Section 1.13

          	
            No Recourse Against Others

          	
            12

          
	 	
            Section 1.14

          	
            Counterparts

          	
            13

          
	 	
            Section 1.15

          	
            Acceptance of Trust

          	
            13

          
	 	
            Section 1.16

          	
            Termination

          	
            13

          
	 	 	 	 
	
            ARTICLE 2 SECURITY FORMS

          	
            13

          
	 	
            Section 2.1

          	
            Forms Generally

          	
            13

          
	 	 	 	 
	
            ARTICLE 3 THE SECURITIES

          	
            14

          
	 	
            Section 3.1

          	
            Title and Terms

          	
            14

          
	 	
            Section 3.2

          	
            Registrable Form

          	
            15

          
	 	
            Section 3.3

          	
            Execution, Authentication, Delivery and Dating

          	
            15

          
	 	
            Section 3.4

          	
            [Intentionally Omitted]

          	
            16

          
	 	
            Section 3.5

          	
            Registration, Registration of Transfer and Exchange

          	
            16

          
	 	
            Section 3.6

          	
            Mutilated, Destroyed, Lost and Stolen Securities

          	
            19

          
	 	
            Section 3.7

          	
            Payments with Respect to CVRs

          	
            19

          
	 	
            Section 3.8

          	
            Persons Deemed Owners

          	
            20

          
	 	
            Section 3.9

          	
            Cancellation

          	
            20

          
	 	
            Section 3.10

          	
            CUSIP Numbers

          	
            20

          
	 	 	 	 
	
            ARTICLE 4 THE TRUSTEE

          	
            20

          
	 	
            Section 4.1

          	
            Certain Duties and Responsibilities

          	
            20

          
	 	
            Section 4.2

          	
            Certain Rights of Trustee

          	
            21

          
	 	
            Section 4.3

          	
            Notice of Default

          	
            23

          
	 	
            Section 4.4

          	
            Not Responsible for Recitals or Issuance of Securities

          	
            23

          
	 	
            Section 4.5

          	
            May Hold Securities

          	
            23

          
	 	
            Section 4.6

          	
            Money Held in Trust

          	
            23

          
	 	
            Section 4.7

          	
            Compensation and Reimbursement

          	
            23

          
	 	
            Section 4.8

          	
            Disqualification; Conflicting Interests

          	
            24

          
	 	
            Section 4.9

          	
            Corporate Trustee Required; Eligibility

          	
            24

          
	 	
            Section 4.10

          	
            Resignation and Removal; Appointment of Successor

          	
            25

          


    

    

    
      i

      
        


    

    	 	
            Section 4.11

          	
            Acceptance of Appointment of Successor

          	
            26

          
	 	
            Section 4.12

          	
            Merger, Conversion, Consolidation or Succession to Business

          	
            26

          
	 	
            Section 4.13

          	
            Preferential Collection of Claims Against Company

          	
            26

          
	 	 	 	 
	
            ARTICLE 5 HOLDERS’ LISTS AND REPORTS BY THE TRUSTEE AND COMPANY

          	
            27

          
	 	
            Section 5.1

          	
            Company to Furnish Trustee Names and Addresses of Holders

          	
            27

          
	 	
            Section 5.2

          	
            Preservation of Information; Communications to Holders

          	
            27

          
	 	
            Section 5.3

          	
            Reports by Trustee

          	
            27

          
	 	
            Section 5.4

          	
            Reports by Company

          	
            28

          
	 	 	 	 
	
            ARTICLE 6 AMENDMENTS

          	
            28

          
	 	
            Section 6.1

          	
            Amendments Without Consent of Holders

          	
            28

          
	 	
            Section 6.2

          	
            Amendments with Consent of Holders

          	
            29

          
	 	
            Section 6.3

          	
            Execution of Amendments

          	
            29

          
	 	
            Section 6.4

          	
            Effect of Amendments; Notice to Holders

          	
            30

          
	 	
            Section 6.5

          	
            Conformity with Trust Indenture Act

          	
            30

          
	 	
            Section 6.6

          	
            Reference in Securities to Amendments

          	
            30

          
	 	 	 	 
	
            ARTICLE 7 COVENANTS

          	
            30

          
	 	
            Section 7.1

          	
            Payment of Amounts, if any, to Holders

          	
            30

          
	 	
            Section 7.2

          	
            Maintenance of Office or Agency

          	
            31

          
	 	
            Section 7.3

          	
            Money for Security Payments to Be Held in Trust

          	
            31

          
	 	
            Section 7.4

          	
            Certain Purchases and Sales

          	
            32

          
	 	
            Section 7.5

          	
            Books and Records

          	
            32

          
	 	
            Section 7.6

          	
            Listing of CVRs

          	
            32

          
	 	
            Section 7.7

          	
            Product Transfer

          	
            32

          
	 	
            Section 7.8

          	
            Diligent Efforts

          	
            33

          
	 	
            Section 7.9

          	
            Confidentiality

          	
            33

          
	 	
            Section 7.10

          	
            Non-Use of Name

          	
            34

          
	 	
            Section 7.11

          	
            Notice of Default

          	
            34

          
	 	 	 	 
	
            ARTICLE 8 REMEDIES OF THE TRUSTEE AND HOLDERS ON EVENT OF DEFAULT

          	
            34

          
	 	
            Section 8.1

          	
            Event of Default Defined; Waiver of Default

          	
            34

          
	 	
            Section 8.2

          	
            Collection by the Trustee; the Trustee May Prove Payment Obligations

          	
            35

          
	 	
            Section 8.3

          	
            Application of Proceeds

          	
            37

          
	 	
            Section 8.4

          	
            Suits for Enforcement

          	
            37

          
	 	
            Section 8.5

          	
            Restoration of Rights on Abandonment of Proceedings

          	
            37

          
	 	
            Section 8.6

          	
            Limitations on Suits by Holders

          	
            38

          
	 	
            Section 8.7

          	
            Unconditional Right of Holders to Institute Certain Suits

          	
            38

          
	 	
            Section 8.8

          	
            Powers and Remedies Cumulative; Delay or Omission Not Waiver of Default

          	
            38

          
	 	
            Section 8.9

          	
            Control by Holders

          	
            39

          
	 	
            Section 8.10

          	
            Waiver of Past Defaults

          	
            39

          


    

    

    
      ii

      
        


    

    	 	
            Section 8.11

          	
            The Trustee to Give Notice of Default, But May Withhold in Certain Circumstances

          	
            39

          
	 	
            Section 8.12

          	
            Right of Court to Require Filing of Undertaking to Pay Costs

          	
            40

          
	 	 	 	 
	
            ARTICLE 9 CONSOLIDATION, MERGER, SALE OR CONVEYANCE

          	
            40

          
	 	
            Section 9.1

          	
            Company May Consolidate, etc., on Certain Terms

          	
            40

          
	 	
            Section 9.2

          	
            Successor Person Substituted

          	
            40

          
	 	
            Section 9.3

          	
            Opinion of Counsel to the Trustee

          	
            41

          
	 	
            Section 9.4

          	
            Successors

          	
            41

          
	 	 	 	 
	
            ARTICLE 10 SUBORDINATION

          	
            41

          
	 	
            Section 10.1

          	
            Agreement to Subordinate

          	
            41

          
	 	
            Section 10.2

          	
            Liquidation; Dissolution; Bankruptcy

          	
            41

          
	 	
            Section 10.3

          	
            Default on Senior Obligations

          	
            42

          
	 	
            Section 10.4

          	
            When Distribution Must Be Paid Over

          	
            42

          
	 	
            Section 10.5

          	
            Notice by Company

          	
            43

          
	 	
            Section 10.6

          	
            Subordination Effective Notwithstanding Deficiencies with Respect to Senior Obligations: Waiver of Right to Contest Senior Obligation: Reinstatement of Subordination Provisions

          	
            43

          
	 	
            Section 10.7

          	
            Subrogation

          	
            44

          
	 	
            Section 10.8

          	
            Relative Rights

          	
            44

          
	 	
            Section 10.9

          	
            Subordination May Not Be Impaired by Company

          	
            44

          
	 	
            Section 10.10

          	
            Distribution or Notice to Representative

          	
            45

          
	 	
            Section 10.11

          	
            Rights of the Trustee

          	
            45

          
	 	
            Section 10.12

          	
            Authorization to Effect Subordination

          	
            45

          
	 	
            Section 10.13

          	
            Amendments

          	45


    

    

    Annex A — Form of Global Security

     

    Annex B — Form of Assignment and Assumption Agreement

     

    Note: This table of contents shall not, for any purpose, be deemed to be a part of this CVR Agreement.

     

    
      iii

      
        


    

    Reconciliation and tie between Trust Indenture Act of 1939 and Contingent Value Rights Agreement, dated as of [____], [___].

     

    	
            
              Trust Indenture Act Section

            

          	 	
            
              Agreement Section

            

          
	
            Section 310

          	
            (a)(1)

          	 	
            4.9

          
	 	
            (a)(2)

          	 	
            4.9

          
	 	
            (a)(3)

          	 	
            Not Applicable

          
	 	
            (a)(4)

          	 	
            Not Applicable

          
	 	
            (a)(5)

          	 	
            4.9

          
	 	
            (b)

          	 	
            4.8, 4.10

          
	 	
            (c)

          	 	
            Not Applicable

          
	 	 	 	 
	
            Section 311

          	
            (a)

          	 	
            4.13

          
	 	
            (b)

          	 	
            4.13

          
	 	
            (c)

          	 	
            Not Applicable

          
	 	 	 	 
	
            Section 312

          	
            (a)

          	 	
            5.1, 5.2(a)

          
	 	
            (b)

          	 	
            5.2(b)

          
	 	
            (c)

          	 	
            5.2(c)

          
	 	 	 	 
	
            Section 313

          	
            (a)

          	 	
            5.3(a)

          
	 	
            (b)

          	 	
            5.3(a)

          
	 	
            (c)

          	 	
            5.3(a), 8.11

          
	 	
            (d)

          	 	
            5.3(b)

          
	 	 	 	 
	
            Section 314

          	
            (a)

          	 	
            5.4, 7.11

          
	 	
            (b)

          	 	
            Not Applicable

          
	 	
            (c)(1)

          	 	
            1.2(a)

          
	 	
            (c)(2)

          	 	
            1.2(a)

          
	 	
            (c)(3)

          	 	
            Not Applicable

          
	 	
            (d)

          	 	
            Not Applicable

          
	 	
            (e)

          	 	
            1.2(b)

          
	 	
            (f)

          	 	
            Not Applicable

          
	 	 	 	 
	
            Section 315

          	
            (a)

          	 	
            4.1(a), 4.1(b)

          
	 	
            (b)

          	 	
            8.11

          
	 	
            (c)

          	 	
            4.1(a)

          
	 	
            (d)

          	 	
            4.1(c)

          
	 	
            (d)(1)

          	 	
            4.1(a), 4.1(b)

          
	 	
            (d)(2)

          	 	
            4.1(c)(ii)

          
	 	
            (d)(3)

          	 	
            4.1(c)(iii)

          
	 	
            (e)

          	 	
            8.12

          
	 	 	 	 
	
            Section 316

          	
            (a)(last sentence)

          	 	
            Not Applicable

          
	 	
            (a)(1)(A)

          	 	
            8.9

          
	 	
            (a)(1)(B)

          	 	
            8.10

          


    

    

    
      iv

      
        


    

    	
            Trust Indenture Act Section

          	 	
            Agreement Section

          
	 	
            (a)(2)

          	 	
            Not Applicable

          
	 	
            (b)

          	 	
            8.7

          
	 	
            (c)

          	 	
            Not Applicable

          
	 	 	 	 
	
            Section 317

          	
            (a)(1)

          	 	
            8.2

          
	 	
            (a)(2)

          	 	
            8.2

          
	 	
            (b)

          	 	
            7.3

          
	 	 	 	 
	
            Section 318

          	
            (a)

          	 	
            1.7

          


    

    

    Note: This reconciliation and tie shall not, for any purpose, be deemed to be a part of this CVR Agreement.

     

    
      v

      
        


    

    THIS CONTINGENT VALUE RIGHTS AGREEMENT, dated as of [_____], [____] (this “CVR Agreement”), by and between Bristol-Myers Squibb Company, a Delaware corporation (the “Company”), and
      Equiniti Trust Company, a limited trust company organized under the laws of the state of New York, as trustee (the “Trustee”), in favor of each person who from time to time holds one or more Contingent Value Rights (the “Securities” or
      “CVRs”) to receive cash payments in the amounts and subject to the terms and conditions set forth herein.

     

    WITNESSETH:

     

    WHEREAS, this CVR Agreement is entered into pursuant to the Agreement and Plan of Merger, dated as of January 2, 2019 (as amended, supplemented or otherwise modified in accordance with its terms, the
      “Merger Agreement”), by and among the Company, Burgundy Merger Sub, Inc., a Delaware corporation and wholly owned Subsidiary of the Company (“Merger Sub”), and Celgene Corporation, a Delaware corporation (“Celgene”);

     

    WHEREAS, pursuant to the Merger Agreement, Merger Sub will merge with and into Celgene (the “Merger”), with Celgene being the surviving corporation in the Merger and becoming a wholly-owned
      Subsidiary of the Company;

     

    WHEREAS, the CVRs shall be issued in accordance with and pursuant to the terms of the Merger Agreement; and

     

    WHEREAS, a registration statement on Form S-4 (No. 333-229464) with respect to the CVRs has been prepared and filed by the Company with the Commission (as defined below) and has become effective in
      accordance with the Securities Act of 1933, as amended.

     

    NOW, THEREFORE, in consideration of the foregoing premises and the consummation of the transactions contemplated by the Merger Agreement, it is covenanted and agreed, for the equal and proportionate
      benefit of all Holders of the Securities, as follows:

     

    ARTICLE 1

    DEFINITIONS AND OTHER PROVISIONS OF GENERAL APPLICATION

     

    Section 1.1          Definitions.  For all purposes of this CVR Agreement, except as otherwise expressly provided or unless the context otherwise requires:

     

    (a)         the terms defined in this Article 1 have the meanings assigned to them in this Article 1, and include the plural as well as the
      singular;

     

    (b)         all capitalized terms used in this CVR Agreement without definition shall have the respective meanings ascribed to them in the
      Merger Agreement;

     

    (c)         all other terms used herein which are defined in the Trust Indenture Act (as defined herein), either directly or by reference
      therein, have the respective meanings assigned to them therein;

     

    
      
        


    

    
    (d)         the words “herein,” “hereof” and “hereunder” and other words of similar import refer to this CVR Agreement as
      a whole and not to any particular Article, Section or other subdivision; and

     

    (e)         whenever the words “include”, “includes” or “including” are used in this CVR Agreement, they shall be deemed
      to be followed by the words “without limitation”, whether or not they are in fact followed by those words or words of like import.

     

    “Affiliate” of any specified Person means any other Person directly or indirectly controlling or controlled by or under direct or indirect common control with such specified Person.  For the
      purposes of this definition, “control” when used with respect to any specified Person means the power to direct the management and policies of such Person, directly or indirectly, whether through the ownership of voting securities, by contract or
      otherwise; and the terms “controlling” and “controlled” have meanings correlative to the foregoing.

     

    “Aggregate Milestone Payment” shall have the meaning set forth in Section 3.1(c) of this CVR Agreement.

     

    “Applicable Procedures” means, with respect to any transfer or exchange of or for beneficial interests in any Global Security, the rules and procedures of the Depositary that apply to such
      transfer or exchange.

     

    “BB2121” means a chimeric antigen receptor (“CAR”) T cell therapy targeting B-cell maturation antigen (BCMA).

     

    “BB2121 Milestone” means the first approval by the FDA of a biologic license application (BLA) that grants Celgene, the Company or any of their respective Affiliates (or their respective
      successors and assigns) the right to commercially manufacture, market and sell BB2121 in the United States in accordance with applicable Law for the treatment of relapsed/refractory multiple myeloma in humans.

     

    “BB2121 Milestone Target Date” means March 31, 2021.

     

    “Board of Directors” means the board of directors of the Company or any other body performing similar functions, or any duly authorized committee of that board.

     

    “Board Resolution” means a copy of a resolution certified by the chairman of the Board of Directors, the chief executive officer, the secretary or any assistant secretary of the Company, to
      have been duly adopted by the Board of Directors and to be in full force and effect on the date of such certification, and delivered to the Trustee.

     

    “Business Day” means any day (other than a Saturday or a Sunday) on which banking institutions in The City of New York, New York or any city in which the Corporate Trust Office of the Trustee
      is located are not authorized or obligated by Law or executive order to close and, if the CVRs are listed on a national securities exchange, electronic trading network or other suitable trading platform, such exchange, electronic network or other
      trading platform is open for trading.

     

    “Celgene” shall have the meaning set forth in the Recitals of this CVR Agreement.

     

    
      2

      
        


    

    “Code” means the U.S. Internal Revenue Code of 1986, as amended.

     

    “Commission” means the Securities and Exchange Commission, as from time to time constituted, created under the Exchange Act (as defined herein), or if at any time after the execution of this
      instrument such Commission is not existing and performing the duties now assigned to it under the Trust Indenture Act, then the body performing such duties at such time.

     

    “Common Stock” shall have the meaning set forth in the Recitals of this CVR Agreement.

     

    “Company” means the Person (as defined herein) named as the “Company” in the first paragraph of this CVR Agreement, until a successor Person shall have become such pursuant to the applicable
      provisions of this CVR Agreement, and thereafter “Company” shall mean such successor Person.  To the extent necessary to comply with the requirements of the provisions of Trust Indenture Act Sections 310 through 317, inclusive, to the extent that
      they are applicable to the Company, the term “Company” shall include any other obligor with respect to the Securities for the purposes of complying with such provisions.

     

    “Company Request” or “Company Order” mean, respectively, a written request or order signed in the name of the Company by the chairman of the Board of Directors, the chief executive
      officer, any President or Vice President, the secretary or any assistant secretary or any other individual duly authorized to act on behalf of the Company for such purpose or for any general purpose, and delivered to the Trustee.

     

    “Confidential Information” shall have the meaning set forth in Section 7.9 of this CVR Agreement.

     

    “Corporate Trust Office” means the office of the Trustee at which at any particular time its corporate trust business shall be principally administered, which office at the date of execution
      of this CVR Agreement is located at 1110 Centre Pointe Curve, Suite 101 Mendota Heights, Minnesota 55120-4101 or such other address as the Trustee may designate from time to time by notice to the Company.

     

    “CVRs” shall have the meaning set forth in the Preamble of this CVR Agreement.

     

    “CVR Agreement” means this instrument as originally executed and as it may from time to time be supplemented or amended pursuant to the applicable provisions hereof.

     

    “Default Interest Rate” means a rate equal to the sum of three percent (3%) plus the prime rate of interest quoted in the Money Rates section of The Wall
        Street Journal (New York Edition), or similar reputable data source, calculated daily on the basis of a three hundred sixty-five (365) day year or, if lower, the highest rate permitted under applicable Law.

     

    “Depositary” shall have the meaning set forth in Section 3.2 of this CVR Agreement.

     

    

    
      3

      
        


    

    “Diligent Efforts” means, with respect to any Product, efforts of a Person to carry out its obligations in a diligent manner using such effort and employing such resources normally used by
      such Person in the exercise of its reasonable business discretion relating to the research, development or commercialization of a product, that is of similar market potential at a similar stage in its development or product life, taking into account
      issues of market exclusivity (including patent coverage, regulatory and other exclusivity), safety and efficacy, product profile (including tolerability and convenience), the competitiveness of alternate products in the marketplace or under
      development, the launch or sales of one or more generic or biosimilar products, actual or likely pricing/reimbursement for the product, the likely timing of the product’s entry into the market, the likelihood of regulatory approval of the product and applicable labeling, and the profitability of the applicable product, and other relevant factors, including technical, commercial, legal, scientific, and/or medical
        factors, based on conditions then prevailing.

     

    “Direct Registration Securities” means Securities, the ownership of which is recorded on the Direct Registration System.  The terms “deliver,” “execute,” “issue,” “register,” “surrender,”
      “transfer” or “cancel,” when used with respect to Direct Registration Securities, shall refer to an entry or entries or an electronic transfer or transfers in the Direct Registration System.

     

    “Direct Registration System” means the system for the uncertificated registration of ownership of securities established by the Security Registrar and utilized by the Security Registrar
      pursuant to which the Security Registrar may record the ownership of CVRs without the issuance of a certificate, which ownership shall be evidenced by periodic statements issued by the Security Registrar to the Holders entitled thereto.

     

    “Event of Default” shall have the meaning set forth in Section 8.1 of this CVR Agreement.

     

    “Exchange Act” means the Securities Exchange Act of 1934, as amended.

     

    “Exchange Act Documents” shall have the meaning set forth in Section 5.4(a) of this CVR Agreement.

     

    “FDA” means the United States Food and Drug Administration or any successor agency.

     

    “Global Securities” means one or more securities in registered form, substantially in the form set forth in Annex A, and held by, or on behalf of, a Depositary.

     

    “Governmental Entity” means any domestic (federal or state), or foreign court, commission, governmental body, regulatory or administrative agency or other political subdivision thereof.

     

    “Holder” means a Person in whose name a Security is registered in the Security Register.

     

    “Indirect Participant” means a Person who holds a beneficial interest in a Global Security through a Participant.

     

    “Initial Milestone Target Date” means December 31, 2020.

     

    “JCAR017” means a CAR T cell therapy targeting CD-19.

     

    
      4

      
        


    

    “JCAR017 Milestone” means the first approval by the FDA of a biologic license application (BLA) that grants Celgene, the Company or any of their respective Affiliates (or their respective
      successors and assigns) the right to commercially manufacture, market and sell JCAR017 in the United States in accordance with applicable Law for the treatment of any relapsed-refractory diffuse large B cell lymphoma in humans.

     

    “Junior Obligations” has the meaning set forth in Section 10.1.

     

    “Law” means any foreign, federal, state, local or municipal laws, rules, judgments orders, regulations, statutes, ordinances, codes, decisions, injunctions, orders, decrees or requirements of any Governmental
      Entity.

     

    “Majority Holders” means, at the time of determination, Holders of at least a majority of the Outstanding CVRs.

     

    “Merger” shall have the meaning set forth in the Recitals of this CVR Agreement.

     

    “Merger Agreement” shall have the meaning set forth in the Recitals of this CVR Agreement.

     

    “Merger Sub” shall have the meaning set forth in the Recitals of this CVR Agreement.

     

    “Milestone” means the satisfaction of all (but not less than all) of the following: (i) the BB2121 Milestone has occurred on or prior to the BB2121 Milestone Target Date; (ii) the JCAR017
      Milestone has occurred on or prior to the Initial Milestone Target Date; and (iii) the Ozanimod Milestone has occurred on or prior to the Initial Milestone Target Date.

     

    “Milestone Payment” means nine dollars ($9.00) per CVR.

     

    “Milestone Payment Date” means, with respect to the Milestone, the date that is selected by the Company that is no later twenty (20) Business Days following the first date on which the
      Milestone is achieved.

     

    “Milestone Payment Record Date” shall have the meaning set forth in Section 3.1(c) of this CVR Agreement.

     

    “Officer’s Certificate” when used with respect to the Company means a certificate signed by the chairman of the Board of Directors, the chief executive officer, any President or Vice
      President, the secretary or any assistant secretary or any other individual authorized to act on behalf of the Company, and delivered to the Trustee.

     

    “Opinion of Counsel” means a written opinion of counsel, who may be counsel for the Company.

     

    
      5

      
        


    

    “Outstanding” when used with respect to Securities means, as of the date of determination, all Securities theretofore authenticated, as applicable, and delivered under this CVR Agreement,
      except: (i) Securities theretofore cancelled by the Trustee or delivered to the Trustee for cancellation and (ii) Securities in exchange for or in lieu of which other Securities have been authenticated, as applicable, and delivered pursuant to this
      CVR Agreement, other than any such Securities in respect of which there shall have been presented to the Trustee proof satisfactory to it that such Securities are held by a bona fide purchaser in whose hands the Securities are valid obligations of
      the Company; provided, however, that in determining whether the Holders of the requisite Outstanding Securities have given any request, demand, direction, consent or waiver hereunder, Securities owned by the Company or any Affiliate
      of the Company, whether held as treasury securities or otherwise, shall be disregarded and deemed not to be Outstanding.

     

    “Ozanimod” means a small molecule sphingosine 1-phosphate receptor modulator, which binds to sphingosine 1-phosphate receptors 1 and 5.

     

    “Ozanimod Milestone” means the first approval by the FDA of a new drug application (NDA) that grants Celgene, the Company or any of their respective Affiliates (or their respective successors
      and assigns) the right to commercially manufacture, market and sell Ozanimod in the United States in accordance with applicable Law for the treatment of relapsing multiple sclerosis in humans.

     

    “Participant” means, with respect to the Depositary, a Person who has an account with the Depositary.

     

    “Party” shall mean the Trustee, the Company and/or Holder(s), as applicable.

     

    “Paying Agent” means any Person authorized by the Company to pay the amount determined pursuant to Section 3.1, if any, on any Securities on behalf of the Company.

     

    “Person” means any individual, corporation, partnership, joint venture, association, joint-stock company, trust, limited liability company, unincorporated organization or Governmental Entity.

     

    “President” when used with respect to the Company, means any president, whether or not designated by a number or a word or words added before or after the title of “president.”

     

    “Products” means each of (a) BB2121, (b) JCAR017 and (c) Ozanimod.

     

    “Representatives” shall have the meaning set forth in Section 7.9 of this CVR Agreement.

     

    “Responsible Officer” when used with respect to the Trustee means any officer assigned to the Corporate Trust Office who shall have direct responsibility for the administration of this CVR
      Agreement or any other officer of the Trustee to whom any corporate trust matter is referred because of such Person’s knowledge of and familiarity with the particular subject.

     

    “Securities” shall have the meaning set forth in the Preamble of this CVR Agreement.

     

    “Security Register” shall have the meaning set forth in Section 3.5(a) of this CVR Agreement.

     

    “Security Registrar” shall have the meaning set forth in Section 3.5(a) of this CVR Agreement.

     

    
      6

      
        


    

    “Senior Obligations” means any existing or future obligations of the Company, including the principal of, premium (if any), interest (including any interest accruing subsequent to the filing
      of a petition of bankruptcy at the rate provided for in the documentation with respect thereto, whether or not such interest is an allowed claim under applicable Law) on, and all other amounts owing thereon, (i) with respect to borrowed money, (ii)
      evidenced by notes, debentures, bonds or other similar debt instruments, (iii) with respect to the net obligations owed under interest rate swaps or similar agreements or currency exchange transactions, (iv) reimbursement obligations in respect of
      letters of credit and similar obligations, (v) in respect of capital leases, or (vi) guarantees in respect of obligations referred to in clauses (i) through (v) above; unless, in any case, the instrument creating or evidencing the same or pursuant to
      which the same is outstanding provides that such obligations are pari passu to or subordinate in right of payment to the Securities.

     

    Notwithstanding the foregoing, “Senior Obligations” shall not include:

     

    
      
        	

              	(A)	
                Junior Obligations;

              


      

    

     

    
      
        	

              	(B)	
                trade debt incurred in the ordinary course of business;

              


      

    

     

    
      
        	

              	(C)	
                any intercompany indebtedness between the Company and any of its Subsidiaries or Affiliates;

              


      

    

     

    
      
        	

              	(D)	
                indebtedness of the Company that is expressly subordinated in right of payment to Senior Obligations;

              


      

    

     

    
      
        	

              	(E)	
                indebtedness or other obligations of the Company that by its terms ranks equal or junior in right of payment to the Junior Obligations;

              


      

    

     

    
      
        	

              	(F)	
                indebtedness of the Company that, by operation of Law, is subordinate to any general unsecured obligations of the Company; or

              


      

    

     

    
      
        	

              	(G)	
                indebtedness evidenced by any guarantee of indebtedness ranking equal or junior in right of payment to the Junior Obligations.

              


      

    

     

    “Subsidiary” means, with respect to any Person, any corporation, limited liability company, association, partnership or other business entity of which more than fifty percent (50%) of the
      total voting power of shares of Voting Securities is at the time owned or controlled, directly or indirectly, by: (i) such Person; (ii) such Person and one or more Subsidiaries of such Person; or (iii) one or more Subsidiaries of such Person.

     

    “Tax” means any federal, state, local or foreign income, profits, gross receipts, license, payroll, employment, severance, stamp, occupation, premium, windfall profits, environmental, customs
      duty, capital stock, franchise, sales, social security, unemployment, disability, use, property, withholding, excise, transfer, registration, production, value added, alternative minimum, occupancy, estimated or any other tax of any kind whatsoever,
      together with any interest, penalty or addition thereto, imposed by any Governmental Entity responsible for the imposition of any such tax, whether disputed or not.

     

    
      7

      
        


    

    “Tax Return” means any return, report, declaration, claim or other statement (including attached schedules) relating to Taxes.

     

    “Termination Date” shall have the meaning set forth in Section 1.16 of this CVR Agreement.

     

    “Trust Indenture Act” means the Trust Indenture Act of 1939, as amended from time to time.

     

    “Trustee” means the Person named as the “Trustee” in the first paragraph of this CVR Agreement, until a successor Trustee shall have become such pursuant to the applicable provisions of this
      CVR Agreement, and thereafter “Trustee” shall mean such successor Trustee.

     

    “Vice President” when used with respect to the Company, means any vice president, whether or not designated by a number or a word or words added before or after the title of “vice president.”

     

    “Voting Securities” means securities or other interests having voting power, or the right, to elect or appoint a majority of the directors, or any Persons performing similar functions,
      irrespective of whether or not stock or other interests of any other class or classes shall have or might have voting power or any right by reason of the happening of any contingency.

     

    Section 1.2          Compliance and Opinions.

     

    (a)          Upon any application or request by the Company to the Trustee to take any action under any provision of this CVR Agreement, the
      Company shall furnish to the Trustee an Officers’ Certificate stating that, in the opinion of the signor, all conditions precedent, if any, provided for in this CVR Agreement relating to the proposed action have been complied with and an Opinion of
      Counsel stating, subject to customary exceptions, that in the opinion of such counsel all such conditions precedent, if any, have been complied with, except that, in the case of any such application or request as to which the furnishing of such
      documents is specifically required by any provision of this CVR Agreement relating to such particular application or request, no additional certificate or opinion need be furnished.

     

    (b)          Every certificate or opinion with respect to compliance with a condition or covenant provided for in this CVR Agreement shall
      include: (i) a statement that each individual signing such certificate or opinion has read such covenant or condition and the definitions herein relating thereto; (ii) a brief statement as to the nature and scope of the examination or investigation
      upon which the statements or opinions contained in such certificate or opinion are based; (iii) a statement that, in the opinion of each such individual, he or she has made such examination or investigation as is necessary to enable him or her to
      express an informed opinion as to whether or not such covenant or condition has been complied with; and (iv) a statement as to whether, in the opinion of each such individual, such condition or covenant has been complied with.

     

    
      8

      
        


    

    Section 1.3           Form of Documents Delivered to Trustee.

     

    (a)         In any case where several matters are required to be certified by, or covered by an opinion of, any specified Person, it is not
      necessary that all such matters be certified by, or covered by the opinion of, only one such Person, or that they be so certified or covered by only one document, but one such Person may certify or give an opinion with respect to some matters and one
      or more other such Persons as to other matters, and any such Person may certify or give an opinion as to such matters in one or several documents.

     

    (b)         Any certificate or opinion of an officer of the Company may be based, insofar as it relates to legal matters, upon a certificate or
      opinion of, or representations by, counsel.  Any such certificate or Opinion of Counsel may be based, insofar as it relates to factual matters, upon a certificate or opinion of, or representations by, an officer or officers of the Company stating
      that the information with respect to such factual matters is in the possession of the Company.

     

    (c)         Any certificate, statement or opinion of an officer of the Company or of counsel may be based, insofar as it relates to accounting
      matters, upon a certificate or opinion of or representations by an accountant or firm of accountants in the employ of the Company.  Any certificate or opinion of any independent firm of public accountants filed with the
        Trustee shall contain a statement that such firm is independent.

     

    (d)         Where any Person is required to make, give or execute two or more applications, requests, consents, certificates, statements,
      opinions or other instruments under this CVR Agreement, they may, but need not, be consolidated and form one instrument.

     

    Section 1.4           Acts of Holders.

     

    (a)          Any request, demand, authorization, direction, notice, consent, waiver or other action provided by this CVR Agreement to be given
      or taken by Holders may be embodied in and evidenced by one or more instruments of substantially similar tenor signed by such Holders in person or by an agent duly appointed in writing; and, except as herein otherwise expressly provided, such action
      shall become effective when such instrument or instruments are delivered to the Trustee and, where it is hereby expressly required, to the Company.  Such instrument or instruments (and the action embodied therein and evidenced thereby) are herein
      sometimes referred to as the “Act” of the Holders signing such instrument or instruments.  Proof of execution of any such instrument or of a writing appointing any such agent shall be sufficient for any purpose of this CVR Agreement and
      (subject to Section 4.1) conclusive in favor of the Trustee and the Company, if made in the manner provided in this Section 1.4.  The Company may set a record date for purposes of determining the identity of Holders entitled to vote
      or consent to any action by vote or consent authorized or permitted under this CVR Agreement.  If not previously set by the Company, (i) the record date for determining the Holders entitled to vote at a meeting of the Holders shall be the date
      preceding the date notice of such meeting is mailed to the Holders, or if notice is not given, on the day next preceding the day such meeting is held, and (ii) the record date for determining the Holders entitled to consent to any action in writing
      without a meeting shall be the first date on which a signed written consent setting forth the action taken or proposed to be taken is delivered to the Company.  If a record date is fixed, those Persons who were Holders of Securities at such record
      date (or their duly designated proxies), and only those Persons, shall be entitled to take such action by vote or consent or, except with respect to clause (d) below, to revoke any vote or consent previously given, whether or not such Persons
      continue to be Holders after such record date.  No such vote or consent shall be valid or effective for more than one hundred twenty (120) days after such record date.

     

    
      9

      
        


    

    (b)         The fact and date of the execution by any Person of any such instrument or writing may be proved in any reasonable manner which the
      Trustee deems sufficient.

     

    (c)          The ownership of Securities shall be proved by the Security Register.  Neither the Company nor the Trustee nor any agent of the
      Company or the Trustee shall be affected by any notice to the contrary.

     

    (d)         At any time prior to (but not after) the evidencing to the Trustee, as provided in this Section 1.4, of the taking of any
      action by the Holders of the Securities specified in this CVR Agreement in connection with such action, any Holder of a Security the serial number of which is shown by the evidence to be included among the serial numbers of the Securities the Holders
      of which have consented to such action may, by filing written notice at the Corporate Trust Office and upon proof of holding as provided in this Section 1.4, revoke such action so far as concerns such Security. 
        Any request, demand, authorization, direction, notice, consent, waiver or other action by the Holder of any Security shall bind every future Holder of the same Security or the Holder of every Security issued upon the registration of transfer
        thereof or in exchange therefor or in lieu thereof, in respect of anything done, suffered or omitted to be done by the Trustee, any Paying Agent or the Company in reliance thereon, whether or not notation of such action is made upon such Security.

     

    Section 1.5           Notices, etc., to Trustee and Company.  Any request, demand, authorization, direction, notice, consent, waiver or Act of Holders or
      other document provided or permitted by this CVR Agreement to be made upon, given or furnished to, or filed with:

     

    (a)          the Trustee by any Holder or by the Company shall be sufficient for every purpose hereunder if made, given, furnished or filed, in
      writing, to or with the Trustee at its Corporate Trust Office; or

     

    (b)          the Company by the Trustee or by any Holder shall be sufficient for every purpose hereunder if in writing and mailed, first-class
      postage prepaid, to the Company addressed to it at:

     

    Bristol-Myers Squibb Company

    430 E. 29th Street, 14th Floor

    New York, New York 10016

    Attn:  Executive Vice President, General Counsel

    

    

    
      10

      
        


    

    
      with copies to (which shall not constitute notice):

       

      

    

    Bristol-Myers Squibb Company

    Route 206 & Province Line Road

    Princeton, New Jersey  08540

    Attn:   Senior Vice President and Deputy General Counsel, Transactional Practice Group

     

    and

     

    Kirkland & Ellis LLP

    601 Lexington Avenue

    New York, New York 10022

    
      	 	
              Attn:

            	
              David Fox, P.C.

            


    

    Daniel Wolf, P.C.

    Jonathan Davis, P.C.

     

    or at any other address previously furnished in writing to the Trustee by the Company.

     

    Section 1.6            Notice to Holders; Waiver.

     

    (a)         Where this CVR Agreement provides for notice to Holders of any event, such notice shall be sufficiently given (unless
      otherwise herein expressly provided) if in writing and mailed, first-class postage prepaid, to each Holder affected by such event, at the Holder’s address as it appears in the Security Register, not later than the latest date, and not earlier than
      the earliest date, prescribed for the giving of such notice.  In any case where notice to Holders is given by mail, neither the failure to mail such notice, nor any defect in any notice so mailed, to any particular Holder shall affect the sufficiency
      of such notice with respect to other Holders.  Where this CVR Agreement provides for notice in any manner, such notice may be waived in writing by the Person entitled to receive such notice, either before or after the event, and such waiver shall be
      the equivalent of such notice.  Waivers of notice by Holders shall be filed with the Trustee, but such filing shall not be a condition precedent to the validity of any action taken in reliance upon such waiver.

     

    (b)          In case by reason of the suspension of regular mail service or by reason of any other cause, it shall be impracticable to mail
      notice of any event as required by any provision of this CVR Agreement, then any method of giving such notice as shall be satisfactory to the Trustee shall be deemed to be a sufficient giving of such notice.

     

    Section 1.7         Conflict with Trust Indenture Act.  If any provision hereof limits, qualifies or conflicts with another provision which is required or
      deemed to be included in this CVR Agreement by any of the provisions of the Trust Indenture Act, such required or deemed provision shall control.

     

    Section 1.8          Effect of Headings and Table of Contents.  The Article and Section headings herein and the Table of Contents are for convenience only
      and shall not affect the construction hereof.

     

    
      11

      
        


    

    Section 1.9           Benefits of Agreement.  Nothing in this CVR Agreement or in the Securities, express or implied, shall give to any Person (other than
      the Parties hereto and their successors hereunder, any Paying Agent and the Holders) any benefit or any legal or equitable right, remedy or claim under this CVR Agreement or under any covenant or provision herein contained, all such covenants and
      provisions being for sole benefit of the Parties hereto and their successors, any Paying Agent and of the Holders.

     

    Section 1.10      Governing Law.  THIS CVR AGREEMENT AND ALL SUITS, ACTIONS, PROCEEDINGS, CLAIMS AND CAUSES OF ACTION (WHETHER IN CONTRACT OR TORT) BASED
      UPON, ARISING OUT OF OR RELATING TO THIS CVR AGREEMENT, THE NEGOTIATION, EXECUTION OR PERFORMANCE OF THIS CVR AGREEMENT OR THE SECURITIES, SHALL BE GOVERNED BY AND CONSTRUED IN ACCORDANCE WITH THE LAWS OF THE STATE OF NEW YORK INCLUDING SECTIONS
      5-1401 AND 5-1402 OF THE NEW YORK GENERAL OBLIGATIONS LAW WITHOUT REGARD TO THE CONFLICT OF LAWS PRINCIPLES THEREOF.  EACH OF THE COMPANY, THE TRUSTEE AND EACH OF THE HOLDERS BY THEIR ACCEPTANCE OF THE SECURITIES, HEREBY IRREVOCABLY SUBMITS TO THE
      EXCLUSIVE JURISDICTION OF ANY NEW YORK STATE COURT SITTING IN THE BOROUGH OF MANHATTAN IN THE CITY OF NEW YORK OR ANY FEDERAL COURT SITTING IN THE BOROUGH OF MANHATTAN IN THE CITY OF NEW YORK IN RESPECT OF ANY SUIT, ACTION, PROCEEDING, CLAIM OR CAUSE
      OF ACTION (WHETHER IN CONTRACT OR TORT) BASED UPON, ARISING OUT OF OR RELATING TO THIS CVR AGREEMENT, THE NEGOTIATION, EXECUTION OR PERFORMANCE OF THIS CVR AGREEMENT OR THE SECURITIES, AND IRREVOCABLY ACCEPTS FOR ITSELF AND IN RESPECT OF ITS
      PROPERTY, GENERALLY AND UNCONDITIONALLY, JURISDICTION OF THE AFORESAID COURTS.  EACH OF THE COMPANY AND THE TRUSTEE AGREES THAT PROCESS MAY BE SERVED UPON THEM IN ANY MANNER AUTHORIZED BY THE LAWS OF THE STATE OF NEW YORK FOR SUCH PERSONS AND
      IRREVOCABLY WAIVES, TO THE FULLEST EXTENT IT MAY EFFECTIVELY DO SO UNDER APPLICABLE LAW, ANY OBJECTION IT MAY NOW OR HEREAFTER HAVE TO SUCH SERVICE OF PROCESS, THE LAYING OF THE VENUE OF ANY SUCH SUIT, ACTION OR PROCEEDING BROUGHT IN ANY SUCH COURT
      AND ANY CLAIM THAT ANY SUCH SUIT, ACTION OR PROCEEDING BROUGHT IN ANY SUCH COURT HAS BEEN BROUGHT IN AN INCONVENIENT FORUM.

     

    Section 1.11         Legal Holidays.  In the event that the Milestone Payment Date shall not be a Business Day, then (notwithstanding any provision of
      this CVR Agreement or the Securities to the contrary) payment on the Securities need not be made on such date, but may be made, without the accrual of any interest thereon, on the next succeeding Business Day with the same force and effect as if made
      on the Milestone Payment Date.

     

    Section 1.12        Separability Clause.  In case any provision in this CVR Agreement or in the CVRs shall be invalid, illegal or unenforceable, the
      validity, legality and enforceability of the remaining provisions shall not in any way be affected or impaired thereby.

     

    Section 1.13       No Recourse Against Others.  A director, officer, employee, agent or representative of the Company or any Affiliate of the Company or
      the Trustee shall not have any liability for any obligations of the Company or the Trustee under the Securities or this CVR Agreement or for any claim based on, in respect of or by reason of such obligations or their
        creation.  By accepting a Security each Holder waives and releases all such liability and all such claims.  The waiver and release are part of the consideration for the issue of the Securities.

     

    
      12

      
        


    

    Section 1.14         Counterparts.  This CVR Agreement shall be signed in any number of counterparts with the same effect as if the signatures to each
      counterpart were upon a single instrument, and all such counterparts together shall be deemed an original of this CVR Agreement.

     

    Section 1.15         Acceptance of Trust.  Equiniti Trust Company, a limited trust company organized under the laws of the state of New York, the Trustee
      named herein, hereby accepts the trusts in this CVR Agreement declared and provided, upon the terms and conditions set forth herein.

     

    Section 1.16         Termination.  This CVR Agreement will, automatically and without any further action of any Party, terminate and be of no force or
      effect, and the Parties hereto shall have no liability or obligations hereunder, at the following time (the “Termination Date”): (a) if as of the end of the day on the Initial Milestone Target Date, either the JCAR017 Milestone or the Ozanimod
      Milestone has not occurred, 12:01 a.m. New York City time on the calendar day following the Initial Milestone Target Date, (b) if both the JCAR017 Milestone and the Ozanimod Milestone have occurred on or prior to the Initial Milestone Target Date
      but, as of the end of the day on the BB2121 Milestone Target Date, the BB2121 Milestone has not occurred, 12:01 a.m. New York City time on the calendar day following the BB2121 Milestone Target Date or (c) if the Milestone has been achieved, the
      calendar day following the date on which the Trustee has paid the Milestone Payment to the Holders in accordance with Section 3.1(c); provided, however, that (A) Sections 1.5, 1.6, 1.7, 1.8, 1.9,
      1.10, 1.12, 1.13, 4.7, 7.5, 7.9, 7.10, Article 8, this Section 1.16 and Section 1.1 (to the extent related to the foregoing) shall survive termination of this CVR
      Agreement in accordance with their terms; and (B) the termination of this CVR Agreement shall not relieve any Party of any liability arising from any material breach of its obligations under this CVR Agreement occurring prior to the Termination Date.
      The Company shall provide the Trustee and Paying Agent written notice (email being sufficient) of the non-occurrence of the Milestone as promptly as practicable thereafter and, if the Milestone has not occurred prior to the BB2121 Milestone Target
      Date, at least seven (7) Business Days following the BB2121 Milestone Target Date (unless the Trustee consents to a shorter notice period).

     

    ARTICLE 2

    SECURITY FORMS

     

    Section 2.1           Forms Generally.

     

    
      (a)        (i) The Global Securities and the Trustee’s certificate of authentication shall be in substantially the forms set forth in
        Annex A, attached hereto and incorporated herein by this reference, with such appropriate insertions, omissions, substitutions and other variations as are required or permitted by this CVR Agreement and may have such letters, numbers or
        other marks of identification and such legends or endorsements placed thereon as may be required to comply with the rules of any securities exchange or as may be required by Law or any rule or regulation pursuant thereto, all as may be determined
        by the officers executing such Global Securities, as evidenced by their execution of the Global Securities.  Any portion of the text of any Global Security may be set forth on the reverse thereof, with an appropriate reference thereto on the face
        of the Global Security.

    

     

    
      13

      
        


    

    (ii) The Global Securities shall be typewritten, printed,
      lithographed or engraved on steel engraved borders or produced by any combination of these methods or may be produced in any other manner permitted by the rules of any securities exchange on which the Securities may be listed, all as determined by
      the officers executing such Global Securities, as evidenced by their execution of such Global Securities.

     

    (b)           The Direct Registration Securities shall be uncertificated and shall be evidenced by the Direct Registration System maintained by
      the Security Registrar.

     

    ARTICLE 3

    THE SECURITIES

     

    Section 3.1          Title and Terms.

     

    (a)         The aggregate number of CVRs which may be authenticated, as applicable, and delivered under this CVR Agreement is limited to a
      number equal to [_____], except for Securities authenticated, as applicable, and delivered upon registration of transfer of, or in exchange for, or in lieu of, other Securities pursuant to Section 3.5, 3.6 or 6.6.  From and after the Merger Effective Time, the Company shall not be permitted to issue any CVRs that have the right to receive any portion of the Milestone Payment, except as provided and in
        accordance with the terms and conditions of the Merger Agreement.

     

    (b)           The Securities shall be known and designated as the “Series B Contingent Value Rights” of the Company.

     

    (c)          If the Milestone is achieved, then, on or prior to the Milestone Payment Date, the Company shall pay, or cause to be paid, to the
      Trustee, by wire transfer to the account designated in writing by the Trustee, an amount equal to the product of (A) the Milestone Payment, multiplied by (B) the number of Securities Outstanding as of such time (the “Aggregate Milestone
        Payment”), and the Trustee shall promptly (and in any event within two (2) Business Days of the receipt of the Aggregate Milestone Payment from the Company) pay to each Holder of record of the Securities as of 5:00 p.m. New York City time,
      three (3) Business Days prior to the Milestone Payment Date (the “Milestone Payment Record Date”) an amount equal to the product of (x) the Milestone Payment, multiplied by (y) the number of Securities held of record by such Holder as
      of the Milestone Payment Record Date.  Subject to Section 1.16, the Company’s obligations to pay the Milestone Payment shall terminate in its entirety on the Termination Date. If the Milestone is achieved, the Company shall notify the Trustee
      and Paying Agent of the Milestone Payment Date in writing (email being sufficient) at least ten (10) Business Days prior to the Milestone Payment Date (unless the Trustee consents to a shorter notice period).  Such notice shall be accompanied by an
      Officer’s Certificate which sets forth, in reasonable detail, the calculation of the Aggregate Milestone Payment to be made to the Holders.

     

    
      14

      
        


    

    (d)          The Holders of the CVRs, by acceptance thereof, agree that no joint venture, partnership or other fiduciary relationship is
      created hereby or by the Securities.

     

    (e)          Other than in the case of interest on amounts due and payable after the occurrence of an Event of Default, no interest or
      dividends shall accrue on any amounts payable in respect of the CVRs.

     

    (f)          The Parties hereto agree to treat the CVRs for all Tax purposes as additional consideration for the shares of Common Stock, the
      Company Stock Options, the Company RSU Awards, the Company PSU Awards and Company RSAs, as applicable, pursuant to the Merger Agreement, and none of the Parties hereto will take any position to the contrary on any Tax Return or for other Tax purposes
      except as otherwise required by applicable Law.  The Company shall report imputed interest on the CVRs pursuant to Section 483 of the Code, except as otherwise required by applicable Law.

     

    

    (g)         The CVRs and any interest thereon may be sold, assigned, pledged encumbered or in any manner transferred or disposed of, in whole
      or in part, only in compliance with applicable United States federal and state securities Laws and, to the extent applicable, in accordance with Section 3.5.

     

    (h)         The Holder of any CVR is not, and shall not, by virtue thereof, be entitled to any rights of a holder of any Voting Securities or
      other equity security or other ownership interest of the Company, in any constituent company to the Merger or in any of their respective Affiliates, either at Law or in equity, and the rights of the Holders are limited to those contractual rights
      expressed in this CVR Agreement.

     

    (i)          Except as provided in this CVR Agreement, none of the Company or any of its Affiliates shall have any right to set-off any amounts
      owed or claimed to be owed by any Holder to any of them against such Holder’s Securities or the Milestone Payment or other amount payable to such Holder in respect of such Securities.

     

    Section 3.2          Registrable Form.  The Securities shall be issuable only in registered form.  The CVRs shall be issued initially in the form of (a)
      one or more permanent Global Securities, deposited with the Trustee, as the custodian for The Depository Trust Company, its nominees and successors (the “Depositary”), or (b) one or more Direct Registration Securities.  Each Global Security
      will represent such of the outstanding CVRs as will be specified therein and each shall provide that it represents the aggregate number of outstanding CVRs from time to time endorsed thereon and that the aggregate number of outstanding CVRs
      represented thereby may from time to time be reduced or increased, as appropriate, to reflect exchanges and/or issuances as provided and in accordance with the terms and conditions of the Merger Agreement. 

     

    Section 3.3           Execution, Authentication, Delivery and Dating.

     

    (a)          The Global Securities shall be executed on behalf of the Company by its chairman of the Board of Directors, its chief executive
      officer, any President or Vice President or any other individual duly authorized to act on behalf of the Company for such purpose or any general purpose, but need not be attested.  The signature of any of these individuals on the Global Securities
      may be manual or facsimile.

     

    
      15

      
        


    

    (b)         Global Securities bearing the manual or facsimile signatures of individuals who were, at the time of execution, the proper officers
      of the Company shall bind the Company, notwithstanding that such individuals or any of them have ceased to hold such offices prior to the authentication and delivery of such Global Securities or did not hold such offices at the date of such Global
      Securities.

     

    (c)          At any time and from time to time after the execution and delivery of this CVR Agreement, the Company may deliver a Company Order
      for the authentication, as applicable, and delivery of Securities, and the Trustee, in accordance with such Company Order, shall authenticate, as applicable, and deliver such Securities as provided in this CVR Agreement and not otherwise.  In the
      case of Global Securities, such Company Order shall be accompanied by Global Securities executed by the Company and delivered to the Trustee for authentication in accordance with such Company Order.

     

    (d)          Each Global Security shall be dated the date of its authentication.

     

    (e)         No Global Security shall be entitled to any benefit under this CVR Agreement or be valid or obligatory for any purpose
      unless there appears on such Security a certificate of authentication substantially in the form provided for herein duly executed by the Trustee, by manual or facsimile signature of an authorized officer, and such certificate upon any Security shall
      be conclusive evidence, and the only evidence, that such Global Security has been duly authenticated and delivered hereunder and that the Holder is entitled to the benefits of this CVR Agreement.

     

    (f)           Direct Registration Securities need not be authenticated, and shall be valid and obligatory for all purposes and shall entitle
      each Holder thereof to all benefits of this CVR Agreement.

     

    Section 3.4            [Intentionally Omitted].

     

    Section 3.5            Registration, Registration of Transfer and Exchange.

     

    (a)           The Company shall cause to be kept at the office of the Trustee a register (the register maintained in such office and in any
      other office or agency designated pursuant to Section 7.2 being herein sometimes referred to as the “Security Register”) in which, subject to such reasonable regulations as it may prescribe, the Company shall provide for the
      registration of Securities and of transfers of Securities.  The Trustee is hereby initially appointed “Security Registrar” for the purpose of registering Securities and transfers of Securities as herein provided.

     

    
      16

      
        


    

    (b)          (i)          A Global Security may not be transferred except as a whole by the Depositary to a nominee of the Depositary, by a
      nominee of the Depositary to the Depositary or to another nominee of the Depositary, or by the Depositary or any such nominee to a successor Depositary or a nominee of such successor Depositary.  All Global Securities will be exchanged by the Company
      for Direct Registration Securities if (1) the Company delivers to the Security Registrar notice from the Depositary that it is unwilling or unable to continue to act as Depositary or that it is no longer a clearing agency registered under the
      Exchange Act and, in either case, a successor Depositary is not appointed by the Company within 120 days after the date of such notice from the Depositary, (2) the Company in its sole discretion determines that the Global Securities (in whole but not
      in part) should be exchanged for Direct Registration Securities and delivers a written notice to such effect to the Security Registrar or (3) an Event of Default has occurred and is continuing and the Security Registrar has received a request from
      the Depositary to issue Direct Registration Securities.  Upon the occurrence of either of the preceding events in (1) or (2) above, Direct Registration Securities shall be issued in such names as the Depositary shall instruct the Trustee.  Global
      Securities also may be exchanged or replaced, in whole or in part, as provided in Section 3.6 hereof.  Every Global Security authenticated and delivered in exchange for, or in lieu of, a Global Security or any portion thereof, pursuant to
      this Sections 3.5 or 3.6 hereof, shall be authenticated and delivered in the form of, and shall be, a Global Security.  A Global Security may not be exchanged for another Global Security other than as provided in this Section
        3.5(b)(i), however, beneficial interests in a Global Security may be transferred and exchanged as provided in Section 3.5(b)(ii) or (iii) hereof.

     

    (ii)         The transfer and exchange of beneficial interests
      in the Global Securities will be effected through the Depositary, in accordance with the provisions of this CVR Agreement and the Applicable Procedures.  Beneficial interests in any Global Security may be transferred to
        Persons who take delivery thereof in the form of a beneficial interest in Global Security.  No written orders or instructions shall be required to be delivered to the Security Registrar to effect the transfers described in this Section 3.5(b)(ii).

     

    (iii)       If any holder of a beneficial interest in a Global
      Security proposes to exchange such beneficial interest for a Direct Registration Security or to transfer such beneficial interest to a Person who takes delivery thereof in the form of a Direct Registration Security, then the Security Registrar will
      cause the aggregate number of CVRs represented by the applicable Global Security to be reduced accordingly pursuant to Section 3.5(b)(vi) hereof, and the Security Registrar will deliver to the Person designated in the instructions a Direct
      Registration Security in the appropriate number of CVRs.  Any Direct Registration Security issued in exchange for a beneficial interest pursuant to this Section 3.5(b)(iii) will be registered in such name or names and in such authorized
      denomination or denominations as the holder of such beneficial interest requests through instructions to the Security Registrar from or through the Depositary and the Participant or Indirect Participant.

     

    (iv)        A Holder of a Direct Registration Security may
      exchange such Direct Registration Security for a beneficial interest in a Global Security or transfer such Direct Registration Security to a Person who takes delivery thereof in the form of a beneficial interest in a Global Security at any time. 
      Upon receipt of a request for such an exchange or transfer together with, in case of a transfer, a duly endorsed or properly executed instrument of transfer in form reasonably satisfactory to the Company and the Security Registrar duly executed by
      the Holder (or by his or her attorney duly authorized in writing and with appropriate evidence of authority), the Security Registrar will cancel the applicable Direct Registration Security and increase or cause to be increased the aggregate number of
      CVRs represented by one of the Global Securities.

     

    
      17

      
        


    

    (v)         Upon request by a Holder of Direct Registration Securities and such Holder’s compliance with the provisions of this Section




        3.5(b)(v), the Security Registrar will register the transfer or exchange of Direct Registration Securities.  Prior to such registration of transfer or exchange, the requesting Holder must present to the Security Registrar a written instruction
      of transfer in form satisfactory to the Company and the Security Registrar duly executed by such Holder (or by his or her attorney, duly authorized in writing and with appropriate evidence of authority), together with a duly endorsed or properly
      executed instrument of transfer.  A Holder of Direct Registration Securities may transfer such Direct Registration Securities to a Person who takes delivery thereof in the form of Direct Registration Securities.  Upon receipt of a request to register
      such a transfer, together with a properly executed instrument of transfer or endorsement and appropriate evidence of authority, which shall include a signature guarantee from an eligible guarantor institution participating in a signature guarantee
      program approved by the Securities Transfer Association, and any other reasonable evidence of authority that may be required by the Security Registrar, the Security Registrar shall register the Direct Registration Securities pursuant to the
      instructions from the Holder thereof.

     

    (vi)        At such time as all beneficial interests in a
      particular Global Security have been exchanged for Direct Registration Securities or a particular Global Security has been repurchased or canceled in whole and not in part, each such Global Security will be returned to or retained and canceled by the
      Security Registrar in accordance with Section 3.9 hereof.  At any time prior to such cancellation, if any beneficial interest in a Global Security is exchanged for or transferred to a Person who will take delivery thereof in the form of a
      beneficial interest in another Global Security or for Direct Registration Securities, the aggregate number of CVRs represented by such Global Security will be reduced accordingly and an endorsement will be made on such Global Security by the Security
      Registrar or by the Depositary at the direction of the Security Registrar to reflect such reduction; and if the beneficial interest is being exchanged for or transferred to a Person who will take delivery thereof in the form of a beneficial interest
      in another Global Security, such other Global Security will be increased accordingly and an endorsement will be made on such Global Security by the Security Registrar or by the Depositary at the direction of the
        Security Registrar to reflect such increase.

     

    (vii)       (A)     To permit registrations of transfers and
      exchanges, the Company will execute and the Trustee will authenticate Global Securities upon receipt of a Company Order in accordance with Section 3.3 hereof or at the Security Registrar’s request.

     

    (B)      No service charge will be made to a Holder of a beneficial interest in a Global Security or to a Holder of a Direct
      Registration Security for any registration of transfer or exchange, but the Company may require payment of a sum sufficient to cover any transfer tax or similar governmental charge payable in connection therewith.

     

    
      18

      
        


    

    (C)     All Global Securities and Direct Registration Securities issued upon any registration of transfer or exchange of Global
      Securities or Direct Registration Securities will be the valid obligations of the Company, evidencing the same rights, and entitled to the same benefits under this CVR Agreement, as the Global Securities or Direct Registration Securities surrendered
      upon such registration of transfer or exchange.

     

    (D)      The Trustee will authenticate Global Securities in accordance with the provisions of Section 3.3 hereof.

     

    Section 3.6            Mutilated, Destroyed, Lost and Stolen Securities.

     

    (a)          If (i) any mutilated Global Security is surrendered to the Trustee, or (ii) the Company and the Trustee receive evidence to their
      satisfaction of the destruction, loss or theft of any Global Security, and there is delivered to the Company and the Trustee such security or indemnity as may be required by them to save each of them harmless, then, in the absence of notice to the
      Company or the Trustee that such Global Security has been acquired by a bona fide purchaser, the Company shall execute and, upon delivery of a Company Order, the Trustee shall authenticate, as applicable, and deliver, in exchange for any such
      mutilated Global Security or in lieu of any such destroyed, lost or stolen Global Security, a new CVR, in the form of either a Global Security or a Direct Registration Security, of like tenor and amount of CVRs, bearing a number not contemporaneously
      outstanding.

     

    (b)         In case any such mutilated, destroyed, lost or stolen Global Security has become or is to become finally due and payable within
      fifteen (15) days, the Company in its discretion may, instead of issuing a new CVR, pay to the Holder of such Security on the Milestone Payment Date all amounts due and payable with respect thereto.

     

    (c)           Every new Security issued pursuant to this Section 3.6 in lieu of any destroyed, lost or stolen Global Security shall
      constitute an original additional contractual obligation of the Company, whether or not the destroyed, lost or stolen Global Security shall be at any time enforceable by anyone, and shall be entitled to all benefits of this CVR Agreement equally and
      proportionately with any and all other Securities duly issued hereunder.

     

    (d)          The provisions of this Section 3.6 are exclusive and shall preclude (to the extent lawful) all other rights and remedies
      with respect to the replacement or payment of mutilated, destroyed, lost or stolen Global Securities.

     

    Section 3.7           Payments with Respect to CVRs.  Payment of any amounts pursuant to the CVRs shall be made in such coin or currency of the United
      States of America as at the time is legal tender for the payment of public and private debts.  The Company may, at its option, pay such amounts by wire transfer or check payable in such money.

     

    
      19

      
        


    

    Section 3.8          Persons Deemed Owners.  The Company, the Trustee and any agent of the Company or the Trustee may treat the Person in whose name any
      Security is registered as the owner of such Security for the purpose of receiving payment on such Security and for all other purposes whatsoever, whether or not such Security be overdue, and neither the Company, the Trustee nor any agent of the
      Company or the Trustee shall be affected by notice to the contrary.

     

    Section 3.9           Cancellation.  All Securities surrendered for payment, registration of transfer or exchange shall, if surrendered to any Person
      other than the Trustee, be delivered to the Trustee and shall be promptly canceled by it.  The Company may at any time deliver to the Trustee for cancellation any Global Securities previously authenticated and delivered hereunder which the Company
      may have acquired in any manner whatsoever, and all Global Securities so delivered shall be promptly canceled by the Trustee.  No Securities shall be authenticated in lieu of or in exchange for any Securities canceled as provided in this Section,
      except as expressly permitted by this CVR Agreement.  All cancelled Global Securities held by the Trustee shall be destroyed and a certificate of destruction shall be issued by the Trustee to the Company, unless otherwise directed by a Company Order.

     

    Section 3.10         CUSIP Numbers.  The Company in issuing the CVRs may use “CUSIP” numbers (if then generally in use), and, if so, the Trustee shall use
      “CUSIP” numbers in notices to the Holders as a convenience to the Holders; provided that any such notice may state that no representation is made as to the correctness of such numbers either as printed on the CVRs or as contained in any notices and
      that reliance may be placed only on the other identification numbers printed on the CVRs, and any such notice shall not be affected by any defect in or omission of such numbers.  The Company will promptly notify the Trustee of any change in the
      “CUSIP” numbers.

     

    ARTICLE 4

    THE TRUSTEE

     

    Section 4.1           Certain Duties and Responsibilities.

     

    (a)          The Trustee, prior to the occurrence of an Event of Default (as defined in Section 8.1) with respect to the Securities and
      after the curing or waiving of all Events of Default which may have occurred, undertakes to perform such duties and only such duties as are specifically set forth in this CVR Agreement and no implied covenants shall be read into this CVR Agreement
      against the Trustee.  In case an Event of Default with respect to the Securities has occurred (which has not been cured or waived), the Trustee shall exercise such of the rights and powers vested in it by this CVR Agreement, and use the same degree
      of care and skill in their exercise, as a reasonably prudent person would exercise or use under the circumstances in the conduct of his or her own affairs.

     

    (b)          In the absence of bad faith on its part, prior to the occurrence of an Event of Default and after the curing or waiving of all
      such Events of Default which may have occurred, the Trustee may conclusively rely, as to the truth of the statements and the correctness of the opinions expressed therein, upon certificates or opinions furnished to the Trustee which conform to the
      requirements of this CVR Agreement; but in the case of any such certificates or opinions which by any provision hereof are specifically required to be furnished to the Trustee, the Trustee shall be under a duty to examine the same to determine
      whether or not they conform to the requirements of this CVR Agreement (but need not confirm or investigate the accuracy of mathematical calculations or the other facts stated therein).

     

    
      20

      
        


    

    (c)           No provision of this CVR Agreement shall be construed to relieve the Trustee from liability for its own negligent action, its own
      negligent failure to act, or its own willful misconduct, except that (i) this Subsection (c) shall not be construed to limit the effect of Subsections (a) and (b) of this Section 4.1; (ii) the Trustee shall not be liable for any error of
      judgment made in good faith by a Responsible Officer, unless it shall be proved that the Trustee was negligent in ascertaining the pertinent facts; and (iii) the Trustee shall not be liable with respect to any action taken or omitted to be taken by
      it in good faith in accordance with the direction of the Holders pursuant to Section 8.9 relating to the time, method and place of conducting any proceeding for any remedy available to the Trustee, or exercising any trust or power conferred
      upon the Trustee, under this CVR Agreement; and (iv) no provision of this CVR Agreement shall require the Trustee to expend its own funds or otherwise incur any financial liability in the performance of any of its duties hereunder or in the exercise
      of any of its rights and powers, to the extent that the Trustee has reasonable grounds, after consultation with outside counsel, for believing that repayment of such funds or adequate indemnity against such liability is not reasonably assured to it.

     

    (d)           Whether or not therein expressly so provided, every provision of this CVR Agreement relating to the conduct or affecting the
      liability of or affording protection to the Trustee shall be subject to the provisions of this Section 4.1.

     

    Section 4.2            Certain Rights of Trustee.  Subject to the provisions of Section 4.1, including the duty of care that the Trustee is
      required to exercise upon the occurrence of an Event of Default:

     

    (a)          the Trustee may rely and shall be protected in acting or refraining from acting upon any resolution, certificate, statement,
      instrument, opinion, report, notice, request, direction, consent, order, bond, debenture, note, other evidence of indebtedness or other paper or document reasonably believed by it to be genuine and to have been signed or presented by the proper party
      or parties and the Trustee need not investigate any fact or matter stated in the document;

     

    (b)          any request or direction or order of the Company mentioned herein shall be sufficiently evidenced by a Company Request or Company
      Order and any resolution of the Board of Directors may be sufficiently evidenced by a Board Resolution;

     

    (c)          whenever in the administration of this CVR Agreement the Trustee shall deem it desirable that a matter be proved or established
      prior to taking, suffering or omitting any action hereunder, the Trustee (unless other evidence be herein specifically prescribed) may, in the absence of bad faith on its part, rely upon an Officers’ Certificate or an Opinion of Counsel;

     

    
      21

      
        


    

    (d)          the Trustee may consult with counsel and the written advice of such counsel or any Opinion of Counsel shall be full and complete
      authorization and protection in respect of any action taken, suffered or omitted by it hereunder in good faith and in accordance with such advice or Opinion of Counsel;

     

    (e)          the Trustee shall be under no obligation to exercise any of the rights or powers vested in it by this CVR Agreement at the request
      or direction of any of the Holders pursuant to this CVR Agreement, unless such Holders shall have offered to the Trustee reasonable security or indemnity against the costs, expenses and liabilities which might be incurred by it in compliance with
      such request or direction;

     

    (f)          the Trustee shall not be bound to make any investigation into the facts or matters stated in any resolution, certificate,
      statement, instrument, opinion, report, notice, request, consent, order, approval, appraisal, bond, debenture, note, coupon, security, or other paper or document, but the Trustee in its discretion may make such further inquiry or investigation into
      such facts or matters as it may see fit, and if the Trustee shall determine to make such further inquiry or investigation, it shall be entitled to examine the pertinent books and records of the Company, personally or by agent or attorney, as may be
      reasonably necessary for such inquiry or investigation and in a manner so as to not unreasonably interfere with the normal business operations of the Company or any of its Affiliates; provided, however, that Company shall not be
      required to provide any books or records to the extent that the provision thereof (i) would, as reasonably determined based on the advice of outside counsel, jeopardize any attorney-client privilege or (ii) would contravene any Law or any contract or
      agreement to which the Company or any of its Affiliates is subject or bound;

     

    (g)         the Trustee may execute any of the trusts or powers hereunder or perform any duties hereunder either directly or by or through
      agents or attorneys and the Trustee shall not be responsible for any misconduct or negligence on the part of any agent or attorney appointed with due care by it hereunder;

     

    (h)          the Trustee shall not be liable for any action taken, suffered or omitted to be taken by it in good faith and reasonably believed
      by it to be authorized or within the discretion or rights or powers conferred upon it by this CVR Agreement; and

     

    (i)           the Trustee shall not be deemed to have notice of any default or Event of Default unless a Responsible Officer of the Trustee has
      actual knowledge thereof or unless written notice thereof has been received by such Responsible Officer at the offices of the Trustee and such notice references the CVRs and this CVR Agreement and the fact that such notice constitutes notification of
      default.

     

    (j)          Subject to Section 4.1, in no event shall the Trustee be responsible or liable for special, incidental, indirect, punitive
      or consequential loss or damage of any kind whatsoever (including, but not limited to, loss of profit) irrespective of whether the Trustee has been advised of the likelihood of such loss or damage and regardless of the form of action; and

     

    
      22

      
        


    

    (k)          the rights, privileges, protections, immunities and benefits given to the Trustee, including, without limitation, its right to be
      indemnified, are extended to, and shall be enforceable by, the Trustee in each of its capacities hereunder, and each Person employed by the Trustee to act hereunder.

     

    Section 4.3           Notice of Default.  If a default occurs hereunder with respect to the Securities, the Trustee shall give the Holders notice of any
      such default actually known to it as and to the extent applicable and provided by the Trust Indenture Act; provided, however, that in the case of any default of the character specified in Section 8.1(b) with respect to the
      Securities, no notice to Holders shall be given until at least thirty (30) days after the occurrence thereof.  For the purpose of this Section 4.3, the term “default” means any event that is, or after notice or lapse of time or both would
      become, an Event of Default with respect to the Securities.

     

    Section 4.4           Not Responsible for Recitals or Issuance of Securities.  The Trustee shall not be accountable for the Company’s use of the
      Securities or the Merger Agreement.  The recitals contained herein and in the Securities, except the Trustee’s certificates of authentication, shall be taken as the statements of the Company, and the Trustee assumes no responsibility




        for their correctness.  The Trustee makes no representations as to the validity or sufficiency of this CVR Agreement or of the Securities or the Merger Agreement. The Trustee is not a party to, is not bound by, and has no duties or obligations
        under, the Merger Agreement unless specifically stated herein.

     

    Section 4.5           May Hold Securities.  The Trustee, any Paying Agent, Security Registrar or any other agent of the Company, in its individual or any
      other capacity, may become the owner or pledgee of Securities, and, subject to Sections 4.8 and 4.13, may otherwise deal with the Company with the same rights it would have if it were not Trustee, Paying Agent, Security Registrar or
      such other agent.

     

    Section 4.6           Money Held in Trust.  Money held by the Trustee in trust hereunder need not be segregated from other funds except to the extent
      required by Law. The Trustee shall be under no liability for interest on any money received by it hereunder, except as otherwise agreed by the Trustee in writing with the Company.

     

    Section 4.7            Compensation and Reimbursement.  The Company agrees:

     

    (a)          to pay to the Trustee from time to time reasonable compensation for all services rendered by it hereunder in such amount as the
      Company and the Trustee shall agree from time to time (which compensation shall not be limited by any provision of Law in regard to the compensation of a trustee of an express trust);

     

    (b)        except as otherwise expressly provided herein, to reimburse the Trustee upon its request for all reasonable and out-of-pocket
      expenses, disbursements and advances incurred or made by the Trustee in accordance with any provision of this CVR Agreement (including the reasonable compensation and the reasonable expenses and disbursements of its agents and counsel), except any
      such expense, disbursement or advance as may be attributable to the Trustee’s negligence, bad faith or willful misconduct; and

     

    
      23

      
        


    

    (c)          to indemnify the Trustee and each of its agents, officers, directors and employees (each an “indemnitee”) for, and to hold
      it harmless against, any loss, liability or reasonable and out-of-pocket expense (including reasonable and out-of-pocket attorneys’ fees and expenses) incurred without negligence, bad faith or willful misconduct on its part, arising out of or in
      connection with the acceptance or administration of this trust and the performance of its duties hereunder, including the reasonable and out-of-pocket costs and expenses of defending itself against any claim or liability in connection with the
      exercise or performance of any of its powers or duties hereunder.  The Company’s payment obligations pursuant to this Section 4.7 shall survive the termination of this CVR Agreement.  When the Trustee incurs reasonable and out-of-pocket
      expenses after the occurrence of an Event of Default specified in Section 8.1(c) or 8.1(d) with respect to the Company, the expenses will constitute expenses of administration under bankruptcy Laws.

     

    Section 4.8          Disqualification; Conflicting Interests.

     

    (a)         If applicable, to the extent that the Trustee or the Company determines that the Trustee has a conflicting interest within the
      meaning of the Trust Indenture Act, the Trustee shall immediately notify the Company of such conflict and, within ninety (90) days after ascertaining that it has such conflicting interest, either eliminate such conflicting interest or resign to the
      extent and in the manner provided by, and subject to the provisions of, the Trust Indenture Act and this CVR Agreement.  The Company shall take prompt steps to have a successor appointed in the manner provided in this CVR Agreement.

     

    (b)          If the Trustee fails to comply with Section 4.8(a), the Trustee shall, within ten (10) days of the expiration of such
      ninety (90) day period, transmit a notice of such failure to the Holders in the manner and to the extent provided in the Trust Indenture Act and this CVR Agreement.

     

    (c)          If the Trustee fails to comply with Section 4.8(a) after written request therefore by the Company or any Holder, then any
      Holder of any Security who has been a bona fide Holder for at least six (6) months may on behalf of himself and all others similarly situated, petition any court of competent jurisdiction for the removal of such Trustee and the appointment of a
      successor Trustee.

     

    Section 4.9           Corporate Trustee Required; Eligibility.  There shall at all times be a Trustee hereunder which satisfies the applicable
      requirements of Sections 310(a)(1) and (5) of the Trust Indenture Act and which, along with its Affiliates, has a combined capital and surplus of at least one hundred fifty million dollars ($150,000,000).  If the Trustee publishes reports of
      condition at least annually, pursuant to Law or to the requirements of a supervising or examining authority, then for the purposes of this Section 4.9, the combined capital and surplus of the Trustee shall be deemed to be its combined capital
      and surplus as set forth in its most recent report of condition so published.  If at any time the Trustee shall cease to be eligible in accordance with the provisions of this Section 4.9, it shall resign immediately in the manner and with the
      effect hereinafter specified in this Article 4.

     

    

    
      24

      
        


    

    
      Section 4.10         Resignation and Removal; Appointment of Successor.

       

      (a)          No resignation or removal of the Trustee and no appointment of a successor Trustee pursuant to this Article 4 shall
        become effective until the acceptance of appointment by the successor Trustee under Section 4.11.

       

      (b)          The Trustee, or any trustee or trustees hereafter appointed, may resign at any time by giving written notice thereof to the
        Company.  If an instrument of acceptance by a successor Trustee shall not have been delivered to the Trustee within thirty (30) days after the giving of such notice of resignation, the resigning Trustee may petition any court of competent
        jurisdiction for the appointment of a successor Trustee.

       

      (c)          The Trustee may be removed at any time by an act of the Majority Holders, delivered to the Trustee and to the Company.

       

      (d)          If at any time:

       

      (i)          the Trustee shall fail to comply with Section 4.8 after written request therefor by the Company or by any Holder
        who has been a bona fide Holder of a Security for at least six (6) months, or

       

      (ii)         the Trustee shall cease to be eligible under Section 4.9 and shall fail to resign after written request therefor by
        the Company or by any such Holder, or

       

      (iii)       the Trustee shall become incapable of acting or shall be adjudged a bankrupt or insolvent, or a receiver of the Trustee or
        of its property shall be appointed, or any public officer shall take charge or control of the Trustee or of its property or affairs for the purpose of rehabilitation, conservation or liquidation,

       

      then, in any case, (A) the Company, by a Board Resolution or an action of the chief executive officer of the Company, may remove the Trustee, or (B) the Holder of any Security who has been a bona fide Holder of a
        Security for at least six (6) months may, on behalf of himself and all others similarly situated, petition any court of competent jurisdiction for the removal of the Trustee and the appointment of a successor Trustee.

       

      (e)         If the Trustee shall resign, be removed or become incapable of acting, or if a vacancy shall occur in the office of Trustee
        for any cause, the Company, by a Board Resolution or an action of the chief executive officer of the Company, shall promptly appoint a successor Trustee.  If, within one year after any resignation, removal or incapacity, or the occurrence of such
        vacancy, a successor Trustee shall be appointed by act of the Majority Holders delivered to the Company and the retiring Trustee, then the successor Trustee so appointed shall, forthwith upon its acceptance of such appointment in accordance with Section




          4.11, become the successor Trustee and supersede the successor Trustee appointed by the Company.  If no successor Trustee shall have been so appointed by the Company or the Majority Holders and accepted appointment within sixty (60) days
        after the retiring Trustee tenders its resignation or is removed, the retiring Trustee may, or, the Holder of any Security who has been a bona fide Holder for at least six (6) months may on behalf of himself and all others similarly situated,
        petition any court of competent jurisdiction for the appointment of a successor Trustee.

       

      
        25

        
          


      

      (f)          The Company shall give notice of each resignation and each removal of the Trustee and each appointment of a successor
        Trustee by mailing written notice of such event by first-class mail, postage prepaid, to the Holders of Securities as their names and addresses appear in the Security Register.  Each notice shall include the name of the successor Trustee and the
        address of its Corporate Trust Office.  If the Company fails to send such notice within ten (10) days after acceptance of appointment by a successor Trustee, it shall not be a default hereunder but the successor Trustee shall cause the notice to be
        mailed at the expense of the Company.

       

      Section 4.11         Acceptance of Appointment of Successor.

       

      (a)         Every successor Trustee appointed hereunder shall execute, acknowledge and deliver to the Company and to the retiring
        Trustee an instrument accepting such appointment, and thereupon the resignation or removal of the retiring Trustee shall become effective and such successor Trustee, without any further act, deed or conveyance, shall become vested with all the
        rights, powers, trusts and duties of the retiring Trustee; but, upon request of the Company or the successor Trustee, such retiring Trustee shall, upon payment of its charges, execute and deliver an instrument transferring to such successor Trustee
        all the rights, powers and trusts of the retiring Trustee, and shall duly assign, transfer and deliver to such successor Trustee all property and money held by such retiring Trustee hereunder.  Upon request of any such successor Trustee, the
        Company shall execute any and all instruments for more fully and certainly vesting in and confirming to such successor Trustee all such rights, powers and trusts.

       

      (b)          No successor Trustee shall accept its appointment unless at the time of such acceptance such successor Trustee shall be
        qualified and eligible under this Article 4.

       

      Section 4.12         Merger, Conversion, Consolidation or Succession to Business.  Any
        Person into which the Trustee may be merged or converted or with which it may be consolidated, or any Person resulting from any merger, conversion or consolidation to which the Trustee shall be a party, or any Person succeeding to all or
        substantially all of the corporate trust business of the Trustee, by sale or otherwise shall be the successor of the Trustee hereunder, provided such Person shall be otherwise qualified and eligible under this Article 4, without the
        execution or filing of any paper or any further act on the part of any of the Parties hereto.  In case any Securities shall have been authenticated, but not delivered, by the Trustee then in office, any successor by merger, conversion, sale or
        consolidation to such authenticating Trustee may adopt such authentication and deliver the Securities so authenticated with the same effect as if such successor Trustee had itself authenticated such Securities; provided that the right to
        adopt the certificate of authentication of any predecessor Trustee shall apply only to its successor or successors by merger, conversion or consolidation.

       

      Section 4.13         Preferential Collection of Claims Against Company.  If and when the
        Trustee shall be or shall become a creditor, directly or indirectly, secured or unsecured, of the Company (or any other obligor upon the Securities), excluding any creditor relationship set forth in Section 311(b) of the Trust Indenture Act, if
        applicable, the Trustee shall be subject to the applicable provisions of the Trust Indenture Act regarding the collection of claims against the Company (or any such other obligor).

       

      
        26

        
          


      

      ARTICLE 5

        HOLDERS’ LISTS AND REPORTS BY THE TRUSTEE AND COMPANY

       

      Section 5.1          Company to Furnish Trustee Names and Addresses of Holders.  The
        Company will furnish or cause to be furnished to the Trustee (a) promptly after the issuance of the Securities, and semi-annually thereafter, a list, in such form as the Trustee may reasonably require, of the names and addresses of the Holders as
        of a recent date, and (b) at such times as the Trustee may request in writing, within thirty (30) days after receipt by the Company of any such request, a list, in such form as the Trustee may reasonably require, of the names and addresses of the
        Holders as of a date not more than fifteen (15) days prior to the time such list is furnished; provided, however, that if and so long as the Trustee shall be the Security Registrar, no such list need be furnished.

       

      Section 5.2           Preservation of Information; Communications to Holders.

       

      (a)         The Trustee shall preserve, in as current a form as is reasonably practicable, the names and addresses of the Holders
        contained in the most recent list furnished to the Trustee as provided in Section 5.1 and the names and addresses of Holders received by the Trustee in its capacity as Security Registrar.  The Trustee may
          destroy any list furnished to it as provided in Section 5.1 upon receipt of a new list so furnished.

       

      (b)          The rights of the Holders to communicate with other Holders with respect to their rights under
        this CVR Agreement and the corresponding rights and privileges of the Trustee shall be as provided by Section 312(b)(2) of the Trust Indenture Act, if applicable.

       

      (c)          Every Holder of Securities, by receiving and holding the same, agrees with the Company and the Trustee that neither the
        Company nor the Trustee shall be deemed to be in violation of Law or held accountable by reason of the disclosure of any such information as to the names and addresses of the Holders made in accordance with Section 5.2(b) regardless of the
        source from which such information was derived, and that the Trustee shall not be held accountable by reason of providing any information pursuant to a request made under Section 5.2(b).

       

      Section 5.3           Reports by Trustee.

       

      (a)          Within sixty (60) days after December 31 of each year commencing with the December 31 following the date of this CVR
        Agreement, the Trustee shall transmit to all Holders such reports concerning the Trustee and its actions under this CVR Agreement as may be required pursuant to Section 313 of the Trust Indenture Act to the extent and in the manner provided
        pursuant thereto.  The Trustee shall also comply with Section 313(b)(2) of the Trust Indenture Act, if applicable.  The Trustee shall also transmit by mail all reports as required by Section 313(c) of the Trust Indenture Act, if applicable.

       

      
        27

        
          


      

      (b)          A copy of each such report shall, at the time of such transmission to the Holders, be filed by the Trustee with each stock
        exchange, if any, upon which the Securities are listed, with the Commission and also with the Company.  The Company will promptly notify the Trustee when the Securities are listed on any stock exchange.

       

      Section 5.4        




          Reports by Company.

       

      (a)          The Company shall file with the Trustee, within fifteen (15) days after the Company files or
        furnishes the same with the Commission, copies of an annual report filed on Form 10-K or a quarterly reports filed on Form 10-Q and of the information, documents and other reports (or copies of such portions of any of the foregoing as the
        Commission may from time to time by rules and regulations prescribe) which the Company is required to file with the Commission pursuant to Section 13 or Section 15(d) of the Exchange Act (such annual and quarterly reports and required information,
        documents and other reports, together the “Exchange Act Documents”).

       

      (b)        Delivery of the reports, information and documents described in Section 5.4(a) shall not constitute constructive
        notice of any information contained therein or determinable there from, including the Company’s compliance with any of its covenants or other obligations hereunder as to which the Trustee is entitled to rely exclusively on Officer’s Certificates.

       

      ARTICLE 6

        AMENDMENTS

       

      Section 6.1           Amendments Without Consent of Holders.  Without the consent of any
        Holders, the Company and the Trustee, at any time and from time to time, may enter into one or more amendments hereto or to the Securities, for any of the following purposes:

       

      (a)          to convey, transfer, assign, mortgage or pledge to the Trustee as security for the Securities any property or assets;

       

      (b)          to evidence the succession of another Person to the Company, and the assumption by any such successor of the covenants of
        the Company herein and in the Securities;

       

      (c)        to add to the covenants of the Company such further covenants, restrictions, conditions or provisions as the Company and the
        Trustee shall consider to be for the protection of the Holders of Securities, and to make the occurrence, or the occurrence and continuance, of a default in any such additional covenants, restrictions, conditions or provisions an Event of Default
        permitting the enforcement of all or any of the several remedies provided in this CVR Agreement as herein set forth; provided, that in respect of any such additional covenant, restriction, condition or provision, such amendment may provide
        for a particular period of grace after default (which period may be shorter or longer than that allowed in the case of other defaults) or may provide for an immediate enforcement upon such an Event of Default or may limit the remedies available to
        the Trustee upon such an Event of Default or may limit the right of the Majority Holders to waive such an Event of Default;

       

      
        28

        
          


      

      (d)          to cure any ambiguity, or to correct or supplement any provision herein or in the Securities which may be defective or
        inconsistent with any other provision herein; provided, that such provisions shall not materially reduce the benefits of this CVR Agreement or the Securities to the Holders;

       

      (e)          to make any other provisions with respect to matters or questions arising under this CVR Agreement; provided, that
        such provisions shall not adversely affect the interests of the Holders;

       

      (f)          to make any amendments or changes necessary to comply or maintain compliance with the Trust Indenture Act, if applicable;
        or

       

      (g)          make any other change that does not adversely affect the interests of the Holders.

       

      Promptly following any amendment of this CVR Agreement or the Securities in accordance with this Section 6.1, the Trustee shall notify the Holders of the Securities of such amendment; provided that
        any failure so to notify the Holders shall not affect the validity of such amendment.

       

      Section 6.2          Amendments with Consent of Holders.  With the consent of the Majority
        Holders, by Act of said Holders delivered to the Company and the Trustee, the Company (when authorized by a Board Resolution or the chief executive officer of the Company) and the Trustee may enter into one or more amendments hereto or to the
        Securities for the purpose of adding any provisions to or changing in any manner or eliminating any of the provisions of this CVR Agreement or to the Securities or of modifying in any manner the rights of the Holders under this CVR Agreement or to
        the Securities; provided, however, that no such amendment shall, without the consent of the Holder of each Outstanding Security affected thereby:

       

      (a)          modify in a manner adverse to the Holders (i) any provision contained herein with respect to the termination of this CVR
        Agreement or the Securities, (ii) the time for payment and amount of the Milestone Payment, or otherwise extend the time for payment of the Securities or reduce the amounts payable in respect of the Securities or modify any other payment term or
        payment date;

       

      (b)          reduce the number of CVRs, the consent of whose Holders is required for any such amendment; or

       

      (c)          modify any of the provisions of this Section 6.2, except to increase the percentage of Holders from whom consent or
        approval is required or to provide that certain other provisions of this CVR Agreement cannot be modified or waived without the consent of the Holder of each Security affected thereby.

       

      It shall not be necessary for any Act of Holders under this Section 6.2 to approve the particular form of any proposed amendment, but it shall be sufficient if such Act shall approve the
        substance thereof.

       

      Section 6.3           Execution of Amendments.  In executing any amendment permitted by
        this Article 6, the Trustee shall be entitled to receive, and (subject to Section 4.1) shall be fully protected in relying upon, an Opinion of Counsel stating that the execution of such amendment is authorized or permitted by this
        CVR Agreement.  The Trustee shall execute any amendment authorized pursuant to this Article 6 if the amendment does not adversely affect the Trustee’s own rights, duties or immunities under this CVR Agreement or otherwise.  Otherwise, the
        Trustee may, but need not, execute such amendment.

       

      
        29

        
          


      

      Section 6.4           Effect of Amendments; Notice to Holders.

       

      (a)          Upon the execution of any amendment under this Article, this CVR Agreement and the Securities shall be modified in
        accordance therewith, and such amendment shall form a part of this CVR Agreement and the Securities for all purposes; and every Holder of Securities theretofore or thereafter authenticated, as applicable, and delivered hereunder shall be bound
        thereby.

       

      (b)         Promptly after the execution by the Company and the Trustee of any amendment pursuant to the provisions of this Article
          6, the Company shall mail a notice thereof by first class mail to the Holders of Securities at their addresses as they shall appear on the Security Register, setting forth in general terms the substance of such amendment.  Any failure of the
        Company to mail such notice, or any defect therein, shall not, however, in any way impair or affect the validity of any such amendment.

       

      Section 6.5           Conformity with Trust Indenture Act.  Every amendment executed
        pursuant to this Article 6 shall conform to the applicable requirements of the Trust Indenture Act, if any.

       

      Section 6.6          Reference in Securities to Amendments.  If an amendment changes the
        terms of a Security, the Trustee may require the Holder of the Security to deliver it to the Trustee.  Global Securities authenticated and delivered after the execution of any amendment pursuant to this Article 6 may, and shall if required
        by the Trustee, bear a notation in form approved by the Trustee as to any matter provided for in such amendment.  If the Company shall so determine, new Securities so modified as to conform, in the opinion of the Trustee, on the on hand, and the
        Board of Directors or the chief executive officer of the Company, on the other hand, to any such amendment may be prepared and executed by the Company, as applicable, and authenticated, as applicable, and delivered by the Trustee in exchange for Outstanding Securities.  Failure to make the appropriate notation or to issue a new Security shall not affect the validity of such amendment.

       

      ARTICLE 7

        COVENANTS

       

      Section 7.1           Payment of Amounts, if any,
          to Holders.  The Company will duly and punctually pay the amounts due, if any, on the Securities in accordance with the terms of this CVR Agreement.  Such amounts shall be considered paid on the Milestone Payment Date if on or prior to such
        date the Company makes, or causes to be made, the payment required pursuant to Section 3.1(c) of this CVR Agreement.  Notwithstanding any other provision of this CVR Agreement, the Company or any of its Affiliates, the Trustee or the Paying Agent, shall be entitled to deduct and withhold, or cause to be deducted and withheld, from any amounts payable or otherwise deliverable pursuant to this CVR Agreement to any Person, such amounts as are
          required to be deducted and withheld therefrom under the Code, or any provision of state, local or foreign Tax Law. To the extent that amounts are so deducted and
          withheld by the Company or any of its Affiliates, the Trustee or the Paying Agent, such withheld amounts shall be (a) paid over to the applicable Governmental Entity in accordance with applicable Law and (b) treated for all purposes of this CVR
          Agreement as having been paid to the Person in respect of which such deduction and withholding was made by the Company or any of its Affiliates, the Trustee or the Paying Agent, as the case may be.  The consent of Holder shall not be required for
          any such withholding.

       

        

      
        30

        
          


      

      Section 7.2           Maintenance of Office or Agency.

       

      (a)         As long as any of the Securities remain Outstanding, the Company will maintain an office or agency (i) where Securities may
        be presented or surrendered for payment, (ii) where Securities may be surrendered for registration of transfer or exchange and (iii) where notices and demands to or upon the Company in respect of the Securities and this CVR Agreement may be
        served.  The office or agency of the Trustee at [1110 Centre Pointe Curve, Suite 101 Mendota Heights, Minnesota 55120-4101] shall be such office or agency of the Company, unless the Company shall designate and maintain some other office or agency
        for one or more of such purposes.  The Company or any of its Subsidiaries may act as Paying Agent, registrar or transfer agent; provided that such Person shall take appropriate actions to avoid the commingling of funds.  The Company will give
        prompt written notice to the Trustee of any change in the location of any such office or agency.  If at any time the Company shall fail to furnish the Trustee with the address thereof, such presentations, surrenders, notices and demands may be made
        or served at the Corporate Trust Office of the Trustee, and the Company hereby appoints the Trustee as its agent to receive all such presentations, surrenders, notices and demands.

       

      (b)         The Company may from time to time designate one or more other offices or agencies where the Securities may be presented or
        surrendered for any or all such purposes, and may from time to time rescind such designation; provided, however, that no such designation or rescission shall in any manner relieve the Company of its obligation to maintain an office or agency for
        such purposes.  The Company will give prompt written notice to the Trustee of any such designation or rescission and any change in the location of any such office or agency.

       

      Section 7.3           Money for Security Payments to Be Held in Trust.

       

      (a)          If the Company or any of its Subsidiaries shall at any time act as the Paying Agent, it will, on or before the Milestone
        Payment Date segregate and hold in trust for the benefit of the Holders all sums held by such Paying Agent for payment on the Securities until such sums shall be paid to the Holders as herein provided, and will
          promptly notify the Trustee of such action or any failure to so act.

       

      (b)          Whenever the Company shall have one or more Paying Agents for the Securities, it will, on or before the Milestone Payment
        Date deposit with a Paying Agent a sum in same day funds sufficient to pay the amount, if any, so becoming due; such sum to be held in trust for the benefit of the Persons entitled to such amount, and (unless such Paying Agent is the Trustee) the
        Company will promptly notify the Trustee of such action or any failure so to act.

       

      

      
        31

        
          


      

      (c)          The Company will cause each Paying Agent other than the Trustee to execute and deliver to the Trustee an instrument in
        which such Paying Agent shall agree with the Trustee, subject to the provisions of this Section 7.3, that such Paying Agent will (i) hold all sums held by it for the payment of any amount payable on Securities in trust for the benefit of
        the Persons entitled thereto until such sums shall be paid to such Persons or otherwise disposed of as herein provided and will notify the Trustee of the sums so held, and (ii) give the Trustee notice of any failure by the Company (or by any other
        obligor on the Securities) to make any payment on the Securities when the same shall be due and payable.

       

      (d)          Any money deposited with the Trustee or any Paying Agent, or then held by the Company, in trust for the payment on any
        Security and remaining unclaimed for one year after the Milestone Payment Date shall be paid to the Company on Company Request, or (if then held by the Company) shall be discharged from such trust; and the Holder of such Security shall thereafter,
        as an unsecured general creditor, look only to the Company for payment thereof, and all liability of the Trustee or such Paying Agent with respect to such trust money shall thereupon cease.

       

      Section 7.4           Certain Purchases and Sales.  Nothing contained herein shall
        prohibit the Company or any of its Subsidiaries or Affiliates from acquiring in open market transactions, private transactions or otherwise, any Securities.

       

      Section 7.5           Books and Records.  During the term of this CVR Agreement and for a
        period of three (3) years after the Termination Date, the Company shall use commercially reasonable efforts to keep, and shall cause its Subsidiaries to use commercially reasonable efforts to keep, true, complete and accurate records in reasonably
        sufficient detail to enable the Holders to determine if the Company has complied with its obligations under this CVR Agreement.

       

      Section 7.6           Listing of CVRs.  The Company hereby covenants and agrees to use
        reasonable best efforts to cause the Securities to be approved for listing (subject to notice of issuance) for trading on the New York Stock Exchange or other national securities exchange and will use its reasonable best efforts to maintain such
        listing for so long as any CVRs remain Outstanding.

       

      Section 7.7          Product Transfer. 




        If the Company or its Affiliates, directly or indirectly, by a sale or swap of assets, merger, reorganization, joint venture, lease, license or any other transaction or arrangement, sells, transfers, conveys or otherwise disposes of its respective
        rights in and to any Product to a third party (other than the Company or any of its Subsidiaries), then the applicable Milestone for such Product (e.g., if the Product is BB2121, then the BB2121 Milestone) shall be deemed to have been satisfied for
        all purposes under this CVR Agreement as of the earlier of the entry into a definitive agreement with respect to, and the consummation of, the transaction or arrangement involving such sale, transfer, conveyance or other disposition; provided,
        that if such sale, transfer, conveyance or other disposition is permitted by Section 9.1, then Section 9.1 shall govern.  For the purposes of clarification, and subject to Section 7.8, the Company may use contract research
        organizations, contract manufacturing organizations, contract sales organizations, subcontractors and distributors in the ordinary course of business to perform research, development, manufacturing and commercialization activities (including
        granting an appropriate sublicense to the extent necessary), without triggering the applicable Milestone.

       

      

      
        32

        
          


      

      Section 7.8           Diligent Efforts.  The Company shall use Diligent Efforts to achieve
        the Milestone.

       

      Section 7.9          Confidentiality.  The Trustee and the Holders hereby agree that any confidential or non-public information they receive from or on behalf of the Company or any Affiliate of the Company, which receipt arises
        out of the transactions contemplated by this CVR Agreement (the “Confidential Information”), shall: (a) not be used for any purpose other than for purposes permitted under this CVR Agreement; (b) not be used directly or indirectly in any way
        that is for competitive purposes; and (c) not be disclosed by, and be kept confidential by, such Trustee and the Holders and its directors, officers, members, managers, employees, affiliates and agents (collectively, “Representatives”); provided,
        however, that any such Confidential Information may be disclosed only to their Representatives who (i) need to know such Confidential Information and (ii) are bound in writing to a non-disclosure agreement no less restrictive than this Section




          7.9.  It is understood that such Representatives shall be informed by the Trustee or the applicable Holder of the confidential nature of such Confidential Information, and that the Trustee or such Holder, as applicable, shall be responsible
        for any disclosure or use made by its Representatives in breach of obligations under this CVR Agreement to the same extent as if such disclosure or use had been made directly by the Trustee or such Holder, as applicable.  Each of the Trustee and
        the Holders will as soon as practicable notify the Company of any breach of this CVR Agreement of which they become aware, and will use commercially reasonable efforts to assist and cooperate with the Company in minimizing the consequences of such
        breach.  “Confidential Information” shall not include any information that is (A) publicly available other than because of or related to any disclosure by the Trustee or the Holders or any of their respective Representatives
        or (B) is lawfully disclosed to the Trustee or Holders by sources (other than the Company or its Affiliates) rightfully in possession of the Confidential Information on a non-confidential basis.  If the Trustee, Holders or their respective
        Representatives are legally required or requested to disclose any Confidential Information, they will in advance of such disclosure, unless otherwise prohibited by Law, promptly notify the Company in writing of such request or requirement so that
        the Company may seek to avoid or minimize the required disclosure and/or obtain an appropriate protective order or other appropriate relief to ensure that any Confidential Information so disclosed is maintained in confidence to the maximum extent
        possible by the person receiving the disclosure, or, in the Company’s discretion, to waive compliance with the provisions of this CVR Agreement.  In any such case, the Trustee and the Holders agree to cooperate
          and use reasonable efforts to avoid or minimize the required disclosure and/or obtain such protective order or other relief.  If, in the absence of a protective order or the receipt of a waiver hereunder, the Trustee, Holders or their respective
          Representatives are legally obligated to disclose any Confidential Information, they will disclose only so much thereof to the party compelling disclosure as they believe in good faith, on the basis of advice of counsel, is required by Law. The
          Trustee and Holders shall, unless otherwise prohibited by Law, give the Company prior written notice of the specific Confidential Information that they believe they are required to disclose under such circumstances.  All Confidential Information
          disclosed by or on behalf of the Company or any of its Affiliates shall be, and shall remain, the property of the Company or such Affiliate.

       

        

      

      
        33

        
          


      

      Section 7.10         Non-Use of Name.  Neither the Trustee nor the Holders shall use the
        name, trademark, trade name, or logo of the Company, its Affiliates or their respective employees, agents or representatives in any publicity or news release relating to this CVR Agreement or its subject matter, without the prior express written
        permission of the Company.

       

      Section 7.11         Notice of Default.  The Company shall file with the Trustee written notice of the occurrence of any
        Event of Default or other default under this CVR Agreement within five (5) Business Days of its becoming aware of such Event of Default or other default.

       

      ARTICLE 8

        REMEDIES OF THE TRUSTEE AND HOLDERS ON EVENT OF DEFAULT

       

      Section 8.1          Event of Default
          Defined; Waiver of Default.  “Event of Default” with respect to the Securities, means each one of the following events which shall have occurred and be continuing (whatever the reason for such Event of Default and whether it shall be
        voluntary or involuntary or be effected by operation of Law or pursuant to any judgment, decree or order of any court or any order, rule or regulation of any administrative or governmental body):

       

      (a)          default in the payment by the Company pursuant to the terms of this CVR Agreement of all or any part of the Milestone
        Payment after a period of ten (10) Business Days after the Milestone Payment shall become due and payable on the Milestone Payment Date; or

       

      (b)         material default in the performance, or breach in any material respect, of any covenant or warranty of the Company in
        respect of the Securities (other than a covenant or warranty in respect of the Securities, a default in whose performance or whose breach is elsewhere in this Section 8.1 specifically dealt with), and continuance of such default or breach
        for a period of ninety (90) days after there has been given, by registered or certified mail, to the Company by the Trustee or to the Company and the Trustee by the Majority Holders, a written notice specifying such default or breach and requiring
        it to be remedied and stating that such notice is a “Notice of Default” hereunder; or

       

      (c)         a court having jurisdiction in the premises shall enter a decree or order for relief in respect of the Company in an
        involuntary case under any applicable bankruptcy, insolvency or other similar Law now or hereafter in effect, or appointing a receiver, liquidator, assignee, custodian, trustee or sequestrator (or similar official) of the Company or for any
        substantial part of its property or ordering the winding up or liquidation of its affairs, and such decree or order shall remain unstayed and in effect for a period of ninety (90) consecutive days; or

       

      (d)          the Company shall commence a voluntary case under any applicable bankruptcy, insolvency or other similar Law now or
        hereafter in effect, or consent to the entry of an order for relief in an involuntary case under any such Law, or consent to the appointment of or taking possession by a receiver, liquidator, assignee, custodian, trustee or sequestrator (or similar
        official) of the Company or for any substantial part of its property, or make any general assignment for the benefit of creditors.

       

      
        34

        
          


      

      If an Event of Default described above occurs and is continuing, then, and in each and every such case, either the Trustee by notice in writing to the Company or the Trustee upon the written
        request of the Majority Holders by notice in writing to the Company (and to the Trustee if given by the Majority Holders), shall bring suit to protect the rights of the Holders, including to obtain payment for any amounts then due and payable,
        which amounts shall bear interest at the Default Interest Rate from the date such amounts were due and payable hereunder until payment is made to the Trustee.

       

      The foregoing provisions of this Section 8.1, however, are subject to the condition that if, at any time after the Trustee shall have begun such suit, and before any judgment or decree for
        the payment of the moneys due shall have been obtained or entered as hereinafter provided, the Company shall pay or shall deposit with the Trustee a sum sufficient to pay all amounts which shall have become due (with interest upon such overdue
        amount at the Default Interest Rate to the date of such payment or deposit) and such amount as shall be sufficient to cover reasonable compensation to the Trustee, its agents, attorneys and counsel, and all other expenses and liabilities incurred
        and all advances made, by the Trustee, and if any and all Events of Default under this CVR Agreement shall have been cured, waived or otherwise remedied as provided herein, then and in every such case the Majority Holders, by written notice to the
        Company and to the Trustee, may waive all defaults with respect to the Securities, but no such waiver or rescission and annulment shall extend to or shall affect any subsequent default or shall impair any right consequent thereof.

       

      Section 8.2          Collection by the Trustee; the Trustee May Prove Payment Obligations. 
        The Company covenants that in case default shall be made in the payment of all or any part of the Securities when the same shall have become due and payable, whether at the Milestone Payment Date or otherwise, then upon demand of the Trustee, the
        Company will pay to the Trustee for the benefit of the Holders of the Securities the whole amount that then shall have become due and payable on all Securities (with interest from the date due and payable to the date of such payment upon the
        overdue amount at the Default Interest Rate); and in addition thereto, such further amount as shall be sufficient to cover the costs and expenses of collection, including reasonable compensation to the Trustee and each predecessor Trustee, their
        respective agents, attorneys and counsel, and any expenses and liabilities incurred, and all advances made, by the Trustee and each predecessor Trustee, except as a result of its negligence, bad faith or willful misconduct.

       

      In case the Company shall fail forthwith to pay such amounts upon such demand, the Trustee, in its own name and as trustee of an express trust, shall be entitled and empowered to institute any
        action or proceedings at Law or in equity for the collection of the sums so due and unpaid, and may prosecute any such action or proceedings to judgment or final decree, and may enforce any such judgment or final decree against the Company or other
        obligor upon such Securities and collect in the manner provided by Law out of the property of the Company or other obligor upon such Securities, wherever situated, the moneys adjudged or decreed to be payable.

       

      
        35

        
          


      

      In any judicial proceedings relative to the Company or other obligor upon the Securities, irrespective of whether any amount is then due and payable with respect to the Securities, the Trustee is
        authorized:

       

      (a)         to file and prove a claim or claims for the whole amount owing and unpaid in respect of the Securities, and to file such
        other papers or documents as may be necessary or advisable in order to have the claims of the Trustee (including any claim for reasonable compensation to the Trustee and each predecessor Trustee, and their respective agents, attorneys and counsel,
        and for reimbursement of all expenses and liabilities incurred, and all advances made, by the Trustee and each predecessor Trustee, except as a result of negligence, bad faith or willful misconduct) and of the Holders allowed in any judicial
        proceedings relative to the Company or other obligor upon the Securities, or to their respective property;

       

      (b)         unless prohibited by and only to the extent required by applicable Law, to vote on behalf of the Holders in any election of
        a trustee or a standby trustee in arrangement, reorganization, liquidation or other bankruptcy or insolvency proceedings or person performing similar functions in comparable proceedings; and

       

      (c)          to collect and receive any moneys or other property payable or deliverable on any such claims, and to distribute all
        amounts received with respect to the claims of the Holders and of the Trustee on their behalf; and any trustee, receiver, or liquidator, custodian or other similar official is hereby authorized by each of the Holders to make payments to the
        Trustee, and, in the event that the Trustee shall consent to the making of payments directly to the Holders, to pay to the Trustee such amounts as shall be sufficient to cover reasonable compensation to the Trustee, each predecessor Trustee and
        their respective agents, attorneys and counsel, and all other expenses and liabilities incurred, and all advances made, by the Trustee and each predecessor Trustee, except as a result of its negligence, bad faith or willful misconduct, and all
        other amounts due to the Trustee or any predecessor Trustee pursuant to Section 4.7.  To the extent that such payment of reasonable compensation, expenses, disbursements, advances and other amounts out of the estate in any such proceedings shall be
        denied for any reason, payment of the same shall be secured by a lien on, and shall be paid out of, any and all distributions, dividends, moneys, securities and other property which the Holders may be entitled to receive in such proceedings,
        whether in liquidation or under any plan of reorganization or arrangement or otherwise.

       

      Nothing herein contained shall be deemed to authorize the Trustee to authorize or consent to or vote for or accept or adopt on behalf of any Holder any plan of reorganization, arrangement,
        adjustment or composition affecting the Securities, or the rights of any Holder thereof, or to authorize the Trustee to vote in respect of the claim of any Holder in any such proceeding except, as aforesaid, to vote for the election of a trustee in
        bankruptcy or similar person.

       

      All rights of action and of asserting claims under this CVR Agreement, or under any of the Securities, may be enforced by the Trustee without the possession of any of the Securities or the
        production thereof and any trial or other proceedings instituted by the Trustee shall be brought in its own name as trustee of an express trust, and any recovery of judgment, subject to the payment of the expenses, disbursements and compensation of
        the Trustee, each predecessor Trustee and their respective agents and attorneys, shall be for the ratable benefit of the Holders.

       

      

      
        36

        
          


      

      In any proceedings brought by the Trustee (and also any proceedings involving the interpretation of any provision of this CVR Agreement to which the Trustee shall be a party) the Trustee shall be
        held to represent all the Holders, and it shall not be necessary to make any Holders of such Securities parties to any such proceedings.

       

      Section 8.3          Application of Proceeds.  Any monies collected by the Trustee pursuant
        to this Article 8 in respect of any Securities shall be applied in the following order at the date or dates fixed by the Trustee upon presentation of the several Securities in respect of which monies have been collected and stamping (or
        otherwise noting) thereon the payment in exchange for the presented Securities if only partially paid or upon surrender thereof if fully paid:

       

      FIRST: To the payment of costs and expenses in respect of which monies have been collected, including reasonable compensation to the Trustee and each predecessor Trustee and their respective agents
        and attorneys and of all expenses and liabilities incurred, and all advances made, by the Trustee and each predecessor Trustee, except as a result of its negligence, bad faith or willful misconduct, and all other amounts due to the Trustee or any
        predecessor Trustee pursuant to Section 4.7;

       

      SECOND: To the payment of the whole amount then owing and unpaid upon all the Securities, with interest at the Default Interest Rate on all such amounts, and in case such monies shall be
        insufficient to pay in full the whole amount so due and unpaid upon the Securities, then to the payment of such amounts without preference or priority of any security over any other Security, ratably to the aggregate of such amounts due and
        payable; and

       

      THIRD: To the payment of the remainder, if any, to the Company or any other person lawfully entitled thereto.

       

      Section 8.4          Suits for Enforcement.  In case an Event of Default has occurred, has
        not been waived and is continuing, the Trustee may in its discretion proceed to protect and enforce its rights and the rights of the Holders under this CVR Agreement by such appropriate judicial proceedings as the Trustee shall deem most effectual
        to protect and enforce any of such rights, either at Law or in equity or in bankruptcy or otherwise, whether for the specific enforcement of any covenant or agreement contained in this CVR Agreement or in aid of the exercise of any power granted in
        this CVR Agreement or to enforce any other legal or equitable right vested in the Trustee by this CVR Agreement or by Law.

       

      Section 8.5          Restoration of Rights on Abandonment of Proceedings.  In case the
        Trustee or any Holder shall have proceeded to enforce any right under this CVR Agreement and such proceedings shall, subject to any determination in such proceeding, have been discontinued or abandoned for any reason, or shall have been determined
        adversely to the Trustee or to such Holder, then and in every such case the Company and the Trustee and the Holders shall be restored respectively to their former positions and rights hereunder, and all rights, remedies and powers of the Company,
        the Trustee and the Holders shall continue as though no such proceedings had been taken.

       

      

      
        37

        
          


      

      Section 8.6          Limitations on Suits by Holders.  Subject to the rights of the Holders
        under Section 8.7, no Holder of any Security shall have any right by virtue or by availing of any provision of this CVR Agreement to institute any action or proceeding at Law or in equity or in bankruptcy or otherwise upon or under or with
        respect to this CVR Agreement, or for the appointment of a trustee, receiver, liquidator, custodian or other similar official or for any other remedy hereunder, unless such Holder previously shall have given to the Trustee written notice of default
        and of the continuance thereof, as hereinbefore provided, and unless the Majority Holders shall also have made written request upon the Trustee to institute such action or proceedings in its own name as trustee hereunder and shall have offered to
        the Trustee such reasonable indemnity as it may require against the costs, expenses and liabilities to be incurred therein or thereby and the Trustee for fifteen (15) days after its receipt of such notice, request and offer of indemnity shall have
        failed to institute any such action or proceeding and no direction inconsistent with such written request shall have been given to the Trustee pursuant to Section 8.9; it being understood and intended that no one or more of such Holders may
        obtain or seek to obtain priority or preference over any other of such Holders or to enforce any right under this CVR Agreement, except for the equal and ratable benefit of all such Holders.  For the protection and enforcement of the provisions of
        this Section 8.6, each and every Holder and the Trustee shall be entitled to such relief as can be given either at Law or in equity.

       

      Section 8.7         Unconditional Right of Holders to Institute Certain Suits. 
        Notwithstanding any other provision in this CVR Agreement and any provision of any Security, the right of any Holder of any Security to receive payment of the amounts payable in respect of such Security on or after the respective due dates
        expressed in such Security, or to institute suit for the enforcement of any such payment on or after such respective dates, shall not be impaired or affected without the consent of such Holder.

       

      Section 8.8          Powers and Remedies Cumulative; Delay or Omission Not Waiver of Default.

       

      (a)          Except as provided in Section 8.6, no right or remedy herein conferred upon or reserved to the Trustee or to the
        Holders is intended to be exclusive of any other right or remedy, and every right and remedy shall, to the extent permitted by Law, be cumulative and in addition to every other right and remedy given hereunder or now or hereafter existing at Law or
        in equity or otherwise.  The assertion or employment of any right or remedy hereunder, or otherwise, shall not prevent the concurrent assertion or employment of any other appropriate right or remedy.

       

      (b)          No delay or omission of the Trustee or of any Holder to exercise any right or power accruing upon any Event of Default
        occurring and continuing as aforesaid shall impair any such right or power or shall be construed to be a waiver of any such Event of Default or an acquiescence therein; and, subject to Section 8.6, every power and remedy given by this CVR Agreement or by Law to the Trustee or to the Holders may be exercised from time to time, and as often as shall be deemed
          expedient, by the Trustee or by the Holders.

       

        

      
        38

        
          


      

      Section 8.9          Control by Holders.

       

      (a)         The Majority Holders shall have the right to direct the time, method and place of conducting any proceeding for any remedy
        available to the Trustee, or exercising any power conferred on the Trustee with respect to the Securities by this CVR Agreement; provided that such direction shall not be otherwise than in accordance with Law and the provisions of this CVR
        Agreement; and provided further that (subject to the provisions of Section 4.1) the Trustee shall have the right to decline to follow any such direction if the Trustee, being advised by counsel, shall determine that the
        action or proceeding so directed may not lawfully be taken or if the Trustee in good faith by its board of directors, the executive committee, or a committee of directors or Responsible Officers of the Trustee shall determine that the action or
        proceedings so directed would involve the Trustee in personal liability or if the Trustee in good faith shall so determine that the actions or forbearances specified in or pursuant to such direction would be unduly prejudicial to the interests of
        Holders of the Securities not joining in the giving of said direction.

       

      (b)          Nothing in this CVR Agreement shall impair the right of the Trustee in its discretion to take any action deemed proper by
        the Trustee and which is not inconsistent with such direction or directions by Holders.

       

      

      Section 8.10         Waiver of Past Defaults.

       

      (a)          In the case of a default or an Event of Default specified in clause (b), (c) or (d) of Section 8.1, the Majority
        Holders may waive any such default or Event of Default, and its consequences except a default in respect of a covenant or provisions hereof which cannot be modified or amended without the consent of the Holder of each Security affected.  In the
        case of any such waiver, the Company, the Trustee and the Holders of the Securities shall be restored to their former positions and rights hereunder, respectively; but no such waiver shall extend to any subsequent or other default or impair any
        right consequent thereon.

       

      (b)        Upon any such waiver, such default shall cease to exist and be deemed to have been cured and not to have occurred, and any
        Event of Default arising therefrom shall be deemed to have been cured, and not to have occurred for every purpose of this CVR Agreement; but no such waiver shall extend to any subsequent or other default or Event of Default or impair any right
        consequent thereon.

       

      Section 8.11         The Trustee to Give Notice of Default, But May Withhold in Certain
          Circumstances.  The Trustee shall transmit to the Holders, as the names and addresses of such Holders appear on the Security Register (as provided under Section 313(c) of the Trust Indenture Act, if applicable), notice by mail of all defaults
        which have occurred and are known to the Trustee, such notice to be transmitted within ninety (90) days after the occurrence thereof, unless such defaults shall have been cured before the giving of such notice (the term “default”





        for the purposes of this Section being hereby defined to mean any event or condition which is, or with notice or lapse of time or both would become, an Event of Default); provided that, except in the case of
          default in the payment of the amounts payable in respect of any of the Securities, the Trustee shall be protected in withholding such notice if and so long as the board of directors, the executive committee, or a trust committee of directors or
          trustees and/or Responsible Officers of the Trustee in good faith determines that the withholding of such notice is in the interests of the Holders.

       

      
        39

        
          


      

      Section 8.12        Right of Court to Require Filing of Undertaking to Pay Costs.  All
        Parties to this CVR Agreement agree, and each Holder of any Security by his acceptance thereof shall be deemed to have agreed, that any court may in its discretion require, in any suit for the enforcement of any right or remedy under this CVR
        Agreement or in any suit against the Trustee for any action taken, suffered or omitted by it as the Trustee, the filing by any party litigant in such suit of an undertaking to pay the reasonable out-of-pocket costs of such suit, and that such court
        may in its discretion assess reasonable out-of-pocket costs, including reasonable out-of-pocket attorneys’ fees, against any party litigant in such suit, having due regard to the merits and good faith of the claims or defenses made by such party
        litigant; but the provisions of this Section 8.12 shall not apply to any suit instituted by the Trustee, to any suit instituted by any Holder or group of Holders holding in the aggregate more than ten percent (10%) of the Securities Outstanding or to any suit instituted by any Holder for the enforcement of the payment of any Security on or after the due date expressed in such Security.

       

      ARTICLE 9

        CONSOLIDATION, MERGER, SALE OR CONVEYANCE

       

      Section 9.1         Company May Consolidate, etc., on Certain Terms.  The Company covenants that it will not merge or consolidate with or into any other Person or sell or
        convey all or substantially all of its assets to any Person, unless (a) either (i) the Company shall be the continuing Person or (ii) the successor Person, or the Person that acquires by sale or conveyance substantially all the assets of the
        Company shall be a Person organized under the Laws of the United States of America or any State thereof, any member of the European Union or the United Kingdom and shall expressly assume, by an assignment and assumption agreement, executed and
        delivered to the Trustee, in substantially the form attached hereto as Annex B, the due and punctual payment of the Milestone Payment and the due and punctual performance and observance of all covenants and conditions of this CVR Agreement
        to be performed or observed by the Company, and (b) immediately after such merger or consolidation, or such sale or conveyance, no default or Event of Default shall have occurred and be continuing.

       

      Section 9.2           Successor Person Substituted.

       

      (a)          In case of an assumption pursuant to Section 9.1(a)(ii), such assuming Person shall succeed to and be substituted
        for the Company with the same effect as if it had been named herein.  Such assuming Person may cause to be signed, and may issue either in its own name (or, if it is the successor to the Company or substantially all assets of the Company, in the
        name of the Company prior to such succession) any or all of the Securities issuable hereunder, in the case of Global Securities, which theretofore shall not have been signed by the Company and delivered to the Trustee; and, upon the order of such
        successor corporation instead of the Company and subject to all the terms, conditions and limitations in this CVR Agreement prescribed, the Trustee shall authenticate and shall deliver any Securities which
          previously shall have been signed and delivered to the Trustee for authentication, and any Securities which such assuming Person thereafter shall cause to be signed and delivered to the Trustee for that purpose.  All of the Securities so issued
          shall in all respects have the same legal rank and benefit under this CVR Agreement as the Securities theretofore or thereafter issued in accordance with the terms of this CVR Agreement as though all of such Securities had been issued at the date
          of the execution hereof.

       

      
        40

        
          


      

      (b)          In case of any such assumption, such changes in phraseology and form (but not in substance) may be made in the Securities
        thereafter to be issued as may be appropriate.

       

      (c)          In the event of any such assumption, the assigning Person shall be discharged from all obligations and covenants under this
        CVR Agreement and the Securities and may be liquidated and dissolved.

       

      Section 9.3         Opinion of Counsel to the Trustee.  The Trustee, subject to the
        provisions of Sections 4.1 and 4.2, shall receive an Officer’s Certificate and Opinion of Counsel, prepared in accordance with Section 1.2 and Section 1.3, as conclusive evidence that any such consolidation, merger,
        sale or conveyance, and any such assumption, and any such liquidation or dissolution, complies with the applicable provisions of this CVR Agreement, and if a supplemental agreement is required in connection with such transaction, such supplemental
        agreement complies with this Article and that there has been compliance with all conditions precedent herein provided for or relating to such transaction.

       

      Section 9.4          Successors.  All covenants, provisions and agreements in this CVR
        Agreement by or for the benefit of the Company, the Trustee or the Holders shall bind and inure to the benefit of their respective successors, assigns, heirs and personal representatives, whether so expressed or not.  The Company may assign this
        CVR Agreement without the prior written consent of the other Parties to this CVR Agreement to one or more of its direct or indirect Subsidiaries, provided, however, that, subject to Section 9.2(a) and (b), in the
        event of any such assignment the Company shall remain subject to its obligations and covenants hereunder, including but not limited to its obligation to make the Milestone Payment.

       

      ARTICLE 10

        SUBORDINATION

       

      Section 10.1        Agreement to Subordinate.  The Company
        agrees, and each Holder by accepting a Security hereunder agrees, that the Milestone Payment, all other obligations under this CVR Agreement and the Securities and any rights or claims relating thereto (collectively, the “Junior Obligations”)




        are subordinated in right of payment, to the extent and in the manner provided in this Article 10, to the prior payment in full in cash or cash equivalents of all Senior Obligations of the Company (whether outstanding on the date hereof or
        hereafter created, incurred, assumed or guaranteed), and that the subordination is for the benefit of the holders of such Senior Obligations.

       

      Section 10.2         Liquidation; Dissolution; Bankruptcy.  Upon any distribution to
        creditors of the Company in a liquidation or dissolution of the Company or in a bankruptcy, reorganization, insolvency, receivership or similar proceeding relating to the Company or its property, in an assignment for the benefit of creditors or any
        marshaling of the Company’s assets and liabilities:

       

      
        41

        
          


      

      (a)          holders of Senior Obligations will be entitled to receive payment in full in cash or cash equivalents of all Senior
        Obligations of the Company (including interest after the commencement of any bankruptcy proceeding at the rate specified in the applicable Senior Obligation, whether or not permitted under such bankruptcy proceedings) before the Holders will be
        entitled to receive any payment of any kind with respect to the Junior Obligations; and

       

      (b)          until all Senior Obligations of the Company (as provided in clause (a) above) are paid in full in cash or cash equivalents,
        any distribution to which Holders would be entitled but for this Article 10 will be made to holders of Senior Obligations of the Company, as their interests may appear.

       

      Section 10.3         Default on Senior Obligations.  The Company may not make any payment
        or distribution to any Holder in respect of Junior Obligations or acquire from any Holder for cash or property any Junior Obligations:

       

      (a)          if any default on any Senior Obligations exceeding twenty-five million dollars ($25,000,000) in aggregate principal amount
        would occur as a result of such payment, distribution or acquisition;

       

      (b)          during the continuance of any payment default in respect of any Senior Obligations (after expiration of any applicable
        grace period) exceeding twenty-five million dollars ($25,000,000) in aggregate principal amount;

       

      (c)          if the maturity of any Senior Obligations representing more than twenty-five million dollars ($25,000,000) in aggregate
        principal amount is accelerated in accordance with its terms and such acceleration has not been rescinded; or

       

      (d)         following the occurrence of any default (other than a payment default, and after the expiration of any applicable grace
        period) with respect to any Senior Obligations with an aggregate principal amount of more than twenty-five million dollars ($25,000,000), the effect of which is to permit the holders of such Senior Obligations (or a trustee or agent acting on their
        behalf) to cause, with the giving of notice if required, the maturity of such Senior Obligations to be accelerated, for a period commencing upon the receipt by the Trustee (with a copy to the Company) of a written notice of such default from the
        representative of the holders of such Senior Obligations and ending when such Senior Obligations are paid in full in cash or cash equivalents or, if earlier, when such default is cured or waived.

       

      Section 10.4         When Distribution Must Be Paid Over.

       

      (a)          In the event that the Trustee or any Holder receives any payment of any Junior Obligations at a time when such payment is
        prohibited by this Article 10, and is notified as such by the Company, such payment will be held by the Trustee or such Holder, in trust for the benefit of, and will be paid forthwith over and delivered, upon written request, to, the
        representative of the holders of Senior Obligations under the agreement, indenture or other document (if any) pursuant to which such Senior Obligations may have been issued, as their respective interests may appear, for application to the payment
        of all such Senior Obligations remaining unpaid to the extent necessary to pay such Senior Obligations in full in accordance with their terms, after giving effect to any concurrent payment or distribution to or for the holders of Senior
        Obligations.

       

      
        42

        
          


      

      (b)         Any amount received by any Holder as a result of direct or indirect credit support for the Junior Obligations from any
        Affiliate of the Company shall be treated as payments received by such Holder from the Company that are subject to the provisions of this Article 10.

       

      (c)         With respect to the holders of Senior Obligations, the Trustee undertakes to perform only those obligations on the part of
        the Trustee as are specifically set forth in this Article 10, and no implied covenants or obligations with respect to the holders of Senior Obligations will be read into this CVR Agreement against the Trustee.  The Trustee will not be
        deemed to owe any fiduciary duty to the holders of Senior Obligations, and will not be liable to any such holders if the Trustee pays over or distributes to or on behalf of Holders or the Company or any other Person money or assets to which any
        holders of Senior Obligations are then entitled by virtue of this Article 10, except if such payment is made as a result of the willful misconduct or gross negligence of the Trustee.

       

      Section 10.5         Notice by Company.  The Company will promptly notify the Trustee of
        any facts known to the Company that would cause a payment of any Junior Obligations to violate this Article 10, but failure to give such notice will not affect the subordination of the Junior Obligations to the Senior Obligations as
        provided in this Article 10.

       

      Section 10.6         Subordination Effective Notwithstanding Deficiencies with Respect to
          Senior Obligations: Waiver of Right to Contest Senior Obligation: Reinstatement of Subordination Provisions.

       

      (a)          The Holders hereby agree that subordination provisions contained in this Article 10 are unconditional, irrespective
        of the validity, regularity or enforceability of the Senior Obligations, the absence of any action to enforce the same, any waiver or consent by any holder of Senior Obligations with respect to any provisions thereof, the recovery of any judgment
        against the Company, any action to enforce the same or any other circumstance which might otherwise constitute a legal or equitable discharge or defense.  Without limiting the foregoing, and notwithstanding anything to the contrary contained
        elsewhere in this CVR Agreement, in the event that the amount of Senior Obligations are reduced or diminished for any reason (other than as a result of the payment in cash or cash equivalents thereof), whether because of the applicability of
        fraudulent conveyance or other applicable Laws, or any other invalidity or limitation on the amount of Senior Obligations, the subordination provisions thereof shall apply to the full amount of Senior Obligations
          (without giving effect to any reduction, invalidity or diminution thereof), and the turnover provisions hereunder shall be fully enforceable with respect to the full amount of Senior Obligations (without giving effect to any such reduction,
          invalidity or diminution thereof), even if the effect thereof is that there will be no (or a limited amount of) Senior Obligations to which the Junior Obligations are subrogated after the payment in full in cash of any of the remaining Senior
          Obligations (without giving effect to any reductions, invalidity or diminution thereof, except for reductions as a result of payments thereof in cash or cash equivalents).

       

      
        43

        
          


      

      (b)         The Trustee and the Holders agree that they shall not (and hereby waive any right to) take any action to contest or
        challenge (or assist or support any other Person in contesting or challenging), directly or indirectly, whether or not in any proceeding (including in any proceeding commenced by or against any Person under any provision of Title 11 of the United
        States Code, as now and hereinafter in effect, or any successor statute or under any other state or federal bankruptcy or insolvency Law, assignments for the benefit of creditors, formal or informal moratoria, compositions, extensions generally
        with creditors, or proceedings seeking reorganization, arrangement, or other similar relief), the validity or enforceability of the Senior Obligations.

       

      (c)          If any payment made or in respect to the Senior Obligations must be disgorged or returned for any reason, the Senior
        Obligations shall be reinstated hereunder and for all purposes of this Article 10 (including the turnover provisions hereof) such payment shall be deemed to have never been made with respect to the Senior Obligations.

       

      Section 10.7        Subrogation.  After all Senior Obligations are paid in full in cash or
        cash equivalents and until the Junior Obligations are paid in full, Holders will be subrogated to the rights of holders of Senior Obligations to receive distributions applicable to Senior Obligations to the extent that distributions otherwise
        payable to the Holders have been applied to the payment of Senior Obligations.  The Holders by accepting the Securities acknowledge that to the extent that the Senior Obligations are determined to be unenforceable, or the Senior Obligations are
        subordinated to other obligations of the Company, such subrogation rights may be impaired.

       

      Section 10.8        Relative Rights.  This Article 10 defines the relative rights
        of Holders and holders of Senior Obligations.  Nothing in this CVR Agreement will:

       

      (a)          impair, as between the Company and Holders, the obligations of the Company under this CVR Agreement and the Securities; or

       

      (b)          affect the relative rights of Holders and creditors of the Company other than their rights in relation to holders of Senior
        Obligations.

       

      (c)          prevent the Trustee or Holder of any Security from exercising all remedies otherwise permitted under this CVR Agreement
        upon default under this CVR Agreement, subject to the rights, if any, under this Article 10 of the holders of Senior Obligations to receive cash, property and securities otherwise payable or deliverable to the Trustee or such Holder of CVR

       

      If the Company fails because of this Article 10 to pay any amounts due in respect of the Securities on a due date in violation of Section 8.1, the failure is still an Event of
        Default. Unless prohibited by this Article 10, nothing contained in this Article 10 shall prevent the Company from making regularly scheduled payments under this CVR Agreement.

       

      Section 10.9        Subordination May Not Be Impaired by Company.  No right of any holder
        of Senior Obligations to enforce the subordination of the Junior Obligations may be impaired by any act or failure to act by the Company or any Holder or by the failure of the Company or any Holder to comply with this CVR Agreement.

       

      
        44

        
          


      

      Section 10.10      Distribution or Notice to Representative.  Whenever a distribution is to
        be made or a notice given to holders of Senior Obligations, the distribution may be made and the notice given to their representative in accordance with the terms of the instrument or other agreement governing such Senior Obligations.  Upon any
        payment or distribution of assets of the Company referred to in this Article 10, the Trustee and the Holders will be entitled to rely upon any order or decree made by any court of competent jurisdiction or upon any certificate of such
        representative or of the liquidating trustee or agent or other Person making any distribution to the Trustee or to the Holders for the purpose of ascertaining the Persons entitled to participate in such distribution, the holders of the Senior
        Obligations and other obligations of the Company, the amount thereof or payable thereon, the amount or amounts paid or distributed thereon and all other facts pertinent thereto or to this Article 10.

       

      Section 10.11      Rights of the Trustee.  Notwithstanding the provisions of this Article




          10 or any other provision of this CVR Agreement, the Trustee will not be charged with knowledge of the existence of any facts that would prohibit the making of any payment or distribution by the Trustee, and the Trustee may continue to make
        payments on the Securities, unless the Trustee has received at its address for notice specified in Section 1.5 at least five (5) Business Days prior to the date of such payment written notice of facts that would cause the payment of any
        Junior Obligations to violate this Article 10.  Only the Company or a representative of Senior Obligations may give the notice and the Trustee shall be fully protected and shall incur no liability prior to receiving said notice.  In the
        event that the Trustee determines in good faith that further evidence is required with respect to the right of any Person as a holder of Senior Obligations to participate in any payment or distribution pursuant to this Article 10, the Trustee may
        request such person to furnish evidence to the reasonable satisfaction of the Trustee as to the amount of Senior Obligations held by such Person, the extent to which such Person is entitled to participate in such payment or distribution and any
        other facts pertinent to the rights of such Person as it relates to this Article 10, and if such evidence is not furnished, the Trustee may defer any payment to such Person pending judicial determination as to the right of such Person to
        receive such payment. Nothing in this Article 10 will impair or subordinate the claims of, or payments to, the Trustee under or pursuant to Section 4.7. The Trustee in its individual or any other capacity may hold Senior Obligations
        with the same rights it would have if it were not the Trustee.

       

      Section 10.12       Authorization to Effect Subordination.  Each Holder, by the Holder’s
        acceptance of the Securities, authorizes and directs the Trustee on such Holder’s behalf to take such action as may be necessary or appropriate to effectuate the subordination as provided in this Article 10, and appoints the Trustee to act
        as such Holder’s attorney-in-fact for any and all such purposes.  If the Trustee (or any other Person acting on behalf of and at the direction of the Majority Holders) does not file a proper proof of claim or proof of debt in the form required in
        any proceeding referred to in Section 8.2 hereof at least thirty (30) days before the expiration of the time to file such claim, the representatives of the Senior Obligations are hereby authorized to file an appropriate claim for and on
        behalf of the Holders of the Securities.

       

      Section 10.13      Amendments.  The provisions of this Article 10 are expressly
        made for the benefit of the holders from time to time of the Senior Obligations, and may not be amended or modified without the written consent of the representatives of the holders of all Senior Obligations.

       

      [Signature Page Follows]

       

      
        45

        
          


      

      IN WITNESS WHEREOF, the Parties hereto have caused this CVR Agreement to be duly executed, all as of the day and year first above written.

       

      
        	
                 

              	
                BRISTOL-MYERS SQUIBB COMPANY

              
	
                 

              	
                 

              	
                 

              
	 	By:	 
	
                 

              	
                 

              	
                Name:

              
	 	 	Title:
	 	 	 
	 	
                
                  Equiniti Trust Company, as the Trustee 

                

              
	 	 	 
	 	By:	 
	 	 	Name:
	 	 	Title:


      

       

      

      
        [Signature Page to CVR Agreement]

         

        

      

      
        
          


      

      ANNEX A

       

      THIS SECURITY IS A GLOBAL SECURITY WITHIN THE MEANING OF THE CONTINGENT VALUE RIGHTS AGREEMENT (THE “CVR AGREEMENT”) HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME OF A DEPOSITARY OR
        A NOMINEE OF A DEPOSITARY OR A SUCCESSOR DEPOSITARY FOR THE BENEFIT OF THE BENEFICIAL OWNERS HEREOF.  THIS SECURITY IS NOT EXCHANGEABLE FOR SECURITIES REGISTERED IN THE NAME OF A PERSON OTHER THAN THE DEPOSITARY OR ITS NOMINEE EXCEPT IN THE LIMITED
        CIRCUMSTANCES DESCRIBED IN THE CVR AGREEMENT, AND NO TRANSFER OF THIS SECURITY (OTHER THAN A TRANSFER OF THIS SECURITY AS A WHOLE BY THE DEPOSITARY TO A NOMINEE OF THE DEPOSITARY OR BY A NOMINEE OF THE DEPOSITARY TO THE DEPOSITARY OR ANOTHER
        NOMINEE OF THE DEPOSITARY) MAY BE REGISTERED EXCEPT IN THE LIMITED CIRCUMSTANCES DESCRIBED IN THE CVR AGREEMENT.

       

      UNLESS AND UNTIL IT IS EXCHANGED IN WHOLE OR IN PART FOR SECURITIES IN DIRECT REGISTRATION FORM, THIS SECURITY MAY NOT BE TRANSFERRED EXCEPT AS A WHOLE BY THE DEPOSITARY TO A NOMINEE OF THE
        DEPOSITARY OR BY A NOMINEE OF THE DEPOSITARY TO THE DEPOSITARY OR ANOTHER NOMINEE OF THE DEPOSITARY OR BY THE DEPOSITARY OR ANY SUCH NOMINEE TO A SUCCESSOR DEPOSITARY OR A NOMINEE OF SUCH SUCCESSOR DEPOSITARY.  UNLESS THIS SECURITY IS PRESENTED BY
        AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY, A NEW YORK CORPORATION (“DTC”) TO THE ISSUER OR ITS AGENT FOR REGISTRATION OF TRANSFER, EXCHANGE, OR PAYMENT, AND ANY CERTIFICATE ISSUED IS REGISTERED IN THE NAME OF CEDE &
        CO. OR IN SUCH OTHER NAME AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC (AND ANY PAYMENT IS MADE TO CEDE & CO. OR TO SUCH OTHER ENTITY AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC), ANY TRANSFER, PLEDGE OR OTHER USE HEREOF
        FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL INASMUCH AS THE REGISTERED OWNER HEREOF, CEDE & CO., HAS AN INTEREST HEREIN.

       

      BRISTOL-MYERS SQUIBB COMPANY

       

      
        	
                No. 

              	
                Certificate for 

              	
                Contingent Value Rights

              
	
                CUSIP

              	
                [________]

              	
                 

              


      

       

      

      This certifies that __________, or registered assigns (the “Holder”), is the registered holder of the number of Contingent Value Rights (“CVRs”
        or “Securities”) set forth above.  Each CVR entitles the Holder, subject to the provisions contained herein and in the CVR Agreement referred to on the reverse hereof, to payments from Bristol-Myers Squibb Company, a Delaware corporation
        (the “Company”), in the amounts and in the forms determined pursuant to the provisions set forth on the reverse hereof and as more fully described in the CVR Agreement referred to on the reverse hereof.  Such payments shall be made by the Company on the Milestone Payment Date, as defined in the CVR Agreement referred to on the reverse hereof, in accordance with the terms of the CVR Agreement.

       

      

      
        A-1

        
          


      

      Payment of any amounts pursuant to this CVR certificate shall be made only to the registered Holder (as defined in the CVR Agreement) of this CVR certificate.  Such payment shall be made at an
        office or agency maintained by the Company for such purpose, in such coin or currency of the United States of America as at the time is legal tender for the payment of public and private debts; provided, however, the Company may pay such amounts by
        wire transfer or check payable in such money.  Equiniti Trust Company has been initially appointed as Paying Agent at its office or agency in [1110 Centre Pointe Curve, Suite 101 Mendota Heights, Minnesota 55120-4101].

       

      Reference is hereby made to the further provisions of this CVR certificate set forth on the reverse hereof, which further provisions shall for all purposes have the same effect as if set forth at this place.

       

      Unless the certificate of authentication hereon has been duly executed by the Trustee referred to on the reverse hereof, this CVR certificate shall not be entitled to any benefit under the CVR Agreement, or be valid or
        obligatory for any purpose.

       

      IN WITNESS WHEREOF, the Company has caused this instrument to be duly executed.

       

      Dated:    [•]

       
        	
                 

              	
                By:

              	
                 

              
	
                 

              	
                 

              	
                Name:

                

              
	 	 	Title:


      

       

      

       

      [Form of Reverse of CVR certificate]

       

      1.            This CVR certificate is issued under and in accordance with the Contingent Value Rights Agreement, dated as of [______], [____] (the “CVR Agreement”), between the Company and
        Equiniti Trust Company, a limited trust company organized under the laws of the State of New York, as trustee (the “Trustee,” which term includes any successor Trustee under the CVR Agreement), and is subject to the
        terms and provisions contained in the CVR Agreement, to all of which terms and provisions the Holder of this CVR certificate consents by acceptance hereof.  The CVR Agreement is hereby incorporated herein by reference and made a part hereof. 
        Reference is hereby made to the CVR Agreement for a full statement of the respective rights, limitations of rights, duties, obligations and immunities thereunder of the Company, the Trustee and the Holders of the CVRs.  All capitalized terms used
        in this CVR certificate without definition shall have the respective meanings ascribed to them in the CVR Agreement.  Copies of the CVR Agreement can be obtained by contacting the Trustee.

       

      2.            On the Milestone Payment Date, the Company shall make the payments required by Section 3.1(c) of the CVR Agreement to the Trustee, for further distribution by the Trustee to
        the Holders in accordance with Section 3.1(c) of the CVR Agreement.

       

      
        A-2

        
          


      

      3.           In the event of any conflict between this CVR certificate and the CVR Agreement, the CVR Agreement shall govern and prevail.

       

      4.           The Milestone Payment, if any, and interest thereon, if any, shall be payable by the Company in such coin or currency of the United States of America as at the time is legal tender for
        the payment of public and private debts; provided, however, that such amounts may be paid check or wire transfer payable in such money.  Equiniti Trust Company has been initially appointed as Paying Agent at its office or agency in
        [1110 Centre Pointe Curve, Suite 101 Mendota Heights, Minnesota 55120-4101].

       

      5.           If an Event of Default occurs and is continuing, either the Trustee by notice in writing to the Company or the Trustee upon the written request of the Majority Holders (by notice in
        writing to the Company (and to the Trustee if given by the Majority Holders), shall bring suit in accordance with the terms and conditions of the CVR Agreement to protect the rights of the Holders, including to obtain payment of all amounts then
        due and payable, with interest at the Default Interest Rate from the date of the Event of Default through the date payment is made or duly provided for.

       

      6.           No reference herein to the CVR Agreement and no provision of this CVR certificate or of the CVR Agreement shall alter or impair the obligation of the Company, which is absolute and
        unconditional, to pay any amounts determined pursuant to the terms hereof and of the CVR Agreement at the times, place and amount, and in the manner, herein prescribed.

       

      7.           The Milestone Payment or any other right, claim or payment of any kind under this CVR certificate, if any, shall be subordinated in right of payment, as set forth in Article 10 of the
        CVR Agreement, to the prior payment in full in cash or cash equivalents of all Senior Obligations whether outstanding on the date of the CVR Agreement or thereafter incurred.

       

      8.           As provided in the CVR Agreement and subject to certain limitations therein set forth, the transfer of the CVRs represented by this CVR certificate is registrable on the Security
        Register, upon surrender of this CVR certificate for registration of transfer at the office or agency of the Company maintained for such purpose, duly endorsed by, or accompanied by a written instrument of transfer in form satisfactory to the
        Company and the Security Registrar duly executed by, the Holder hereof or his attorney duly authorized in writing, and thereupon one or more new CVR certificates or Direct Registration Securities, for the same amount of CVRs, will be issued to the
        designated transferee or transferees.  The Company hereby initially designates the office of Trustee at [1110 Centre Pointe Curve, Suite 101 Mendota Heights, Minnesota 55120-4101] as the office for registration of transfer of this CVR certificate.

       

      9.           As provided in the CVR Agreement and subject to certain limitations therein set forth, this CVR certificate is exchangeable for one or more CVR certificates or Direct Registration Securities representing the same number of CVRs as represented by this CVR certificate as requested by the Holder surrendering the same.

       

      10.         No service charge will be made for any registration of transfer or exchange of CVRs, but the Company may require payment of a sum sufficient to cover all documentary, stamp or similar
        issue or transfer taxes or other governmental charges payable in connection with any registration of transfer or exchange.

       

      
        A-3

        
          


      

      11.          Prior to the time of due presentment of this CVR certificate for registration of transfer, the Company, the Trustee and any agent of the Company or the Trustee may treat the Person in
        whose name this CVR certificate is registered as the owner hereof for all purposes, and neither the Company, the Trustee nor any agent shall be affected by notice to the contrary.

       

      12.          Neither the Company nor the Trustee has any duty or obligation to the holder of this CVR certificate, except as expressly set forth herein or in the CVR Agreement.

       

      
        A-4

        
          


      

      TRUSTEE’S CERTIFICATE OF AUTHENTICATION

       

      This is one of the Global Securities referred to in the within-mentioned CVR Agreement.

       

      
        	
                 

              	
                [__________], as the Trustee

              
	 	 	 
	
                Dated:   [•]

              	 	 
	 	 	 
	 	By:	 
	
                 

              	
                 

              	
                Authorized Signatory

              


      

       

      

      
        A-5

        
          


      

      Annex B

       

      Form of Assignment and Assumption Agreement

       

      ASSIGNMENT AND ASSUMPTION AGREEMENT, made as of [_____], [_____] (this “Agreement”), between Bristol-Myers Squibb Company, a Delaware corporation (“Assignor”), and [_____], a [___] (“Assignee”). 
        Unless otherwise defined herein, capitalized terms used in this Agreement shall have the meanings given to them in the CVR Agreement referred to below.

       

      W I T N E S S E T H:

       

      WHEREAS, Assignor and [Trustee], as trustee (the “Trustee”) are parties to a Contingent Value Rights Agreement dated as of [____], [_____] (the “CVR Agreement”); and

       

      WHEREAS, Assignor and Assignee desire to execute and deliver this Agreement evidencing the assignment to Assignee of due and punctual payment of the Milestone Payment and the performance and observance of every term,
        covenant, obligation and condition of the CVR Agreement of Assignor to be performed and observed and the assumption thereof by Assignee.

       

      NOW, THEREFORE, in consideration of the premises and for other good and valuable consideration, the receipt and sufficiency of which is hereby acknowledged, Assignor and Assignee hereby agree as follows:

       

      
        
          	1.	
                  Assignment.  Effective as of [______] (the “Assignment Date”), Assignor hereby assigns to Assignee, and Assignee hereby
                      accepts the assignment of, the due and punctual payment of the Milestone Payment and the performance and observance of all terms, covenants, obligations and conditions of the CVR Agreement on the part of Assignor to be performed or
                      observed.

                


        

      

       

      
        
          	2.	
                  Assumption.  Effective as of the Assignment Date, Assignee hereby assumes the due and punctual payment of the Milestone Payment and
                      the performance and observance of all terms, covenants, obligations and conditions of the CVR Agreement on the part of Assignor to be performed or observed.

                


        

      

       

      
        
          	3.	
                  Successors and Assigns.  This Agreement shall be binding upon and shall inure to the benefit of the respective parties hereto and
                      their respective successors and assigns.

                


        

      

       

      
        
          	4.	
                  Governing Law.  This Agreement shall be governed by, construed and enforced in accordance with the laws of New York, without giving
                      effect to the principles of conflicts of laws thereof.

                


        

      

       

      
        
          	5.	
                  Counterparts.  This Agreement may be executed in one or more counterparts, each of which shall be deemed an original but all of
                      which together will constitute one and the same instrument.

                


        

      

       

      
        B-1

        
          


      

      IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be duly executed, all as of the day and year first above written.

       

      
        
          	
                   

                	
                  BRISTOL-MYERS SQUIBB COMPANY

                
	
                   

                	
                   

                	
                   

                
	 	By:	 
	
                   

                	
                   

                	
                  Name:

                
	 	 	Title:
	 	 	 
	 	[ASSIGNEE]
	 	 	 
	 	By:	 
	 	 	Name:
	 	 	Title:


           

          

           

          

           B-2