21004 Federal Register / Vol. 65, No. 76 / Wednesday, April 19, 2000 / Notices

No. 60/089,842, filing date 06/19/1998,

‘‘Novel Thiolesters and Uses Thereof’’,

PCT International Patent Application

No. PCT/US99/13856, International

Filing Date 06/18/1999.

The zinc finger has been found in

many proteins and in a great variety of

species (e.g., the zinc finger structure

can be found in the human

immunodeficiency virus (HIV)). In

viruses, the zinc-binding domains of

nucleocapsid proteins have been

identified as being involved in both

early and late phases of viral

replication, thus making them

potentially attractive targets for antiviral

agents.

The present invention provides for a

novel family of thiolesters and uses

thereof. These thiolesters are capable of

inactivating viruses and other agents by

a variety of mechanisms, particularly by

complexing with metal ion-complexing

zinc fingers. The invention further

provides for methods for inactivating a

virus, such as HIV, using these

compounds, and thereby also inhibiting

transmission of the virus.

The prospective exclusive license will

be royalty-bearing and will comply with

the terms and conditions of 35 U.S.C.

209 and 37 CFR 404.7. The prospective

exclusive license may be granted unless,

within 60 days from the date of this

published Notice, NIH receives written

evidence and argument that establishes

that the grant of the license would not

be consistent with the requirements of

35 U.S.C. 209 and 37 CFR 404.7.

The field of use may be limited to the

use of novel thiolesters of the invention

for therapeutic and diagnostic uses for

anti-viral and anti-retroviral (including

anti-HIV/AIDS), anti-tumor, antiparasitic (e.g., malaria), anti-bacterial,

and anti-fungal applications, as well as

for agricultural uses (e.g., insecticidal

use).

Properly filed competing applications

for a license filed in response to this

notice will be treated as objections to

the contemplated license. Comments

and objections submitted in response to

this notice will not be made available

for public inspection, and, to the extent

permitted by law, will not be released

under the Freedom of Information Act

(FOIA), 5 U.S.C. 552.

Dated: April 13, 2000.

Jack Spiegel,

Director, Division of Technology Development

and Transfer, Office of Technology Transfer.

[FR Doc. 00–9809 Filed 4–18–00; 8:45 am]

BILLING CODE 4140–01–P]

DEPARTMENT OF HEALTH AND

HUMAN SERVICES

Public Health Service

National Toxicology Program; National

Toxicology Program (NTP) Board of

Scientific Counselors Technical

Reports Review Subcommittee

Meeting; Review of Draft NTP

Technical Reports

Pursuant to Public Law 92–463,

notice is hereby given of the next

meeting of the NTP Board of Scientific

Counselors Technical Reports Review

Subcommittee on May 18, 2000 in the

Rodbell Auditorium, Building 101,

South Campus, National Institute of

Environmental Health Sciences

(NIEHS), 111 Alexander Drive, Research

Triangle Park, North Carolina. The

meeting will begin at 8:30 a.m. on May

18 and is open to the public. The

primary agenda topic is the peer review

of draft Technical Reports of long-term

toxicology and carcinogenesis studies

from the NTP. There will also be a

presentation about the beneficial effects

of the NIH2000 diet in chronic studies.

Tentatively scheduled for peer review

on May 18 are draft Technical Reports

of six two-year studies, listed

alphabetically in the attached table,

along with supporting material. Studies

were conducted using Fischer 344 rats

and/or B6C3F1 mice. The tentative order

of review is given in the far right

column of the table.

Draft Reports Available for Public

Review and Comment

Approximately one month prior to the

meeting, the draft reports will be

available for public review and

comment on the Internet free of charge

through the Environmental Health

Information Service (EHIS) at http://

ehis.niehs.nih.gov. Printed copies can

be obtained, as available, from: Central

Data Management, NIEHS, PO Box

12233 MD E1–02, Research Triangle

Park, NC 27709, T: 919–541–3419, FAX:

919–541–3687, or email:

CDM@niehs.nih.gov.

The NTP Board of Scientific

Counselors Technical Reports Review

Subcommittee meeting is open to the

public and public comment on any of

the Technical Reports is welcome. Time

will be provided for public comment on

each of the reports under review. In

order to facilitate planning for the

meeting, persons requesting time for an

oral presentation on a particular

Technical Report are asked to notify the

Executive Secretary, Dr. Mary S. Wolfe

(PO Box 12233, MD A3–07, Research

Triangle Park, NC 27709; telephone 919/

541–3971; FAX 919/541–0295; email

wolfe@niehs.nih.gov). Persons

registering to make comments are asked

to provide, if possible, a written copy of

their statement by May 12th to enable

review by the Subcommittee and staff

prior to the meeting. Written statements

can supplement and may expand the

oral presentation, and each speaker is

asked to provide his/her name,

affiliation, mailing address, phone, fax,

e-mail and supporting organization (if

any). At least seven minutes will be

allotted to each speaker, and if time

permits, may be extended to 10 minutes.

Registration for making public

comments will also be available on-site.

If registering on-site to speak and

reading oral comments from printed

copy, the speaker is asked to bring 25

copies of the text. These copies will be

distributed to the Chair and

Subcommittee members and

supplement the record.

Written comments, in lieu of making

oral comments, are also welcome. The

comments should include name,

affiliation, mailing address, phone, fax,

e-mail and sponsoring organization (if

any) and preferably be received by May

12th to enable review by the

Subcommittee and staff prior to the

meeting.

Request for Additional Information

The NTP would welcome receiving

toxicology and carcinogenesis

information from completed, ongoing,

or planned studies as well as current

production data, human exposure

information, and use patterns for any of

the chemicals listed in this

announcement. Please forward this

information to Central Data

Management at the address given above

who will relay it to the appropriate staff

scientist.

The agenda and a roster of

Subcommittee members will be

available prior to the meeting on the

NTP web homepage at http://ntpserver.niehs.nih.gov and upon request

from the Executive Secretary. Following

the meeting, summary minutes will be

available on the NTP web homepage

and upon request to Dr. Wolfe.

Attachment

Dated: April 11, 2000.

Samuel H. Wilson,

Deputy Director, National Institute of

Environmental Health Sciences.

Federal Register / Vol. 65, No. 76 / Wednesday, April 19, 2000 / Notices 21005

TECHNICAL REPORTS TENTATIVELY SCHEDULED FOR REVIEW BY THE NTP BOARD OF SCIENTIFIC COUNSELORS

TECHNICAL REPORTS REVIEW SUBCOMMITTEE ON MAY 18, 2000

Chemical CAS No. Report

No. Primary uses Route and exposure levels Revieworder

Chloral Hydrate 302–17–0 ............. TR–502 The primary sedative used in children.Gavage (water vehicle) Mice: 0,

25, 50, or 100 mg/kg.

4

Chloral Hydrate (feed restricted)

302–17–0.

TR–503 The primary sedative used in children.Gavage (water vehicle; feed restriction study) Male Mice: 0, 25,

50, or 100 mg/kg.

5

p,p′-Dichlorodiphenyl Sulfone 80–

07–9.

TR–501 Starting product in production of

polysulfones and polyethersulfones; by-product of pesticide

production.

Feed Male Rats: 0, 10, 30, or 100

ppm; Female Rats & Mice: 0, 30,

100, or 300 ppm.

6

Indium Phosphide 22398–80–7 ...... TR–499 Used in making semiconductors,

lasers, solar cells, and

photodiodes.

Inhalation Rats & Mice: 0, 0.03,

0.1, or 0.3 mg/m 3.

1

Naphthalene 91–20–3 .................... TR–500 Ingredient in moth repellants and

toilet bowl deodorants and as an

intermediate in a variety of

chemical synthesis processes.

Inhalation Rats: 0, 10, 30, or 60

ppm.

2

Sodium Nitrite 7632–00–0 .............. TR–495 Color fixative and preservative in

meats and fish; also used in a

variety of industrial processes.

Drinking water Rats & Mice: 0,

750, 1500, or 3000 ppm.

3

[FR Doc. 00–9810 Filed 4–18–00; 8:45 am]

BILLING CODE 4140–01–P

DEPARTMENT OF HOUSING AND

URBAN DEVELOPMENT

[Docket No. FR–4561–N–29]

Notice of Submission of Proposed

Information Collection to OMB;

Manufactured Home Construction and

Safety Standards Program

AGENCY: Office of the Chief Information

Officer, HUD.

ACTION: Notice.

SUMMARY: The proposed information

collection requirement described below

has been submitted to the Office of

Management and Budget (OMB) for

review, as required by the Paperwork

Reduction Act. The Department is

soliciting public comments on the

subject proposal.

DATES: Comments Due Date: May 19,

2000.

ADDRESSES: Interested persons are

invited to submit comments regarding

this proposal. Comments should refer to

the proposal by name and/or OMB

approval number (2502–0233) and

should be sent to: Joseph F. Lackey, Jr.,

OMB Desk Officer, Office of

Management and Budget, Room 10235,

New Executive Office Building,

Washington, DC 20503.

FOR FURTHER INFORMATION CONTACT:

Wayne Eddins, Reports Management

Officer, Q, Department of Housing and

Urban Development, 451 Seventh Street,

Southwest, Washington, DC 20410; email Wayne Eddin@HUD.gov;

telephone (202) 708–2374. This is not a

toll-free number. Copies of the proposed

forms and other available documents

submitted to OMB may be obtained

from Mr. Eddins.

SUPPLEMENTARY INFORMATION: The

Department has submitted the proposal

for the collection of information, as

described below, to OMB for review, as

required by the Paperwork Reduction

Act (44 U.S.C. Chapter 35). The Notice

lists the following information: (1) The

title of the information collection

proposal; (2) the office of the agency to

collect the information; (3) the OMB

approval number, if applicable; (4) the

description of the need for the

information and its proposed use; (5)

the agency form number, if applicable;

(6) what members of the public will be

affected by the proposal; (7) how

frequently information submissions will

be required; (8) an estimate of the total

number of hours needed to prepare the

information submission including

number of respondents, frequency of

response, and hours of response; (9)

whether the proposal is new, an

extension, reinstatement, or revision of

an information collection,

reinstatement, or revision of an

information collection requirement; and

(10) the name and telephone number of

an agency official familiar with the

proposal and of the OMB Desk Officer

for the Department.

This Notice also lists the following

information:

Title of Proposal: Manufactured Home

Construction and Safety Standards

Program.

OMB Approval Number: 2502–0233.

Form Numbers: HUD–101, –203,

–203–B, –301, –302, –303, –304.

Description of the Need for the

Information and Its Proposed Use: The

Manufactured Home Construction and

Safety Standards Act authorizes HUD to

promulgate and enforce reporting

standards for the production of

manufactured housing. HUD uses the

information collected to support an

inspection program and to facilitate

recalls as necessary.

Respondents: Business or other forprofit entities.

Frequency of Submission: On

occasion.

Reporting Burden Number of

Respondents × Frequencyof response × Hours perresponse = Burdenhours

283 24 1.2 8,032