| 1.   | Purpose:    Ore      is in the business of pharmaceutical product development and financing      (the “Business”) and Consultant has special expertise in that      field.  Ore wishes to obtain advisory services from Consultant      and Consultant is willing to provide services to Ore.  The      purpose of this Agreement is to establish the terms upon which such      services will be provided. |
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| 2.   | Services. |
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| a.   | Subject      to the terms and conditions of this Agreement, Ore hereby appoints      Consultant as a consultant and Consultant hereby accepts such      appointment.  Consultant agrees that, during the term of this      Agreement and any subsequent extension thereto, he will provide his      services as requested by Ore’s Chief Executive Officer (“CEO”) or any      other executive at Ore designated by theCEO. |
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| b.   | As      requested with respect to the Business,      Consultant will, |
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|   | i.   |   | Evaluate      product development strategies;                                            |
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|   | ii.  |   | Recommend      product development strategies;                                           |
|   | iii. |   | Critique      proposed product development initiatives;                                  |
|   | iv.  |   | Refer      Ore to potential new business opportunities appropriate to the      Business; |
|   | v.   |   | Advise      on scientific data interpretation and  presentation;                         |
|   | vi.  |   | Otherwise      advise Ore with respect to the Business; and                              |
|   | vii. |   | Provide      such other services as may be mutually agreed by the      parties           |

| c.   | The      services may be provided by meetings or by telephone, e-mail or other      written communication. If requested, Consultant will meet or communicate      with Ore representatives at times and places to be mutually      agreed. |
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| d.   | Consultant      shall provide services to Ore based on the proprietary and/or confidential      information provided by Ore and/or developed by Consultant in the course      of providing services hereunder and shall devote such time as reasonably      necessary to provide the requested services.  Subject to the      provisions of Section 10, Consultant agrees to perform the services in a      timely and professional manner consistent with industry      standards. |
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| 3.   | Compensation. |
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| a.   |  In      consideration for the services during the term of this Agreement and while      this Agreement is in force, Consultant shall  receive: |
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| i.   | a      retainer at a rate of $30,000 per year payable in arrears in quarterly      installments, and |
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| ii.   | payment      for specific services at a rate of one thousand dollars ($1000.00) per      day. |
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| b.   | The      Board of Directors has agreed that, at such time as the shareholders of      Ore have approved the adoption by the Company of an equity plan allowing      for the issuance of options to consultants of the Company, the Company      will grant to Consultant pursuant to the terms of such plan and on the      date of the meeting at which such shareholder approval occurs, an option      to purchase 40,000 shares of Common Stock of Ore, with an exercise price      equal to the fair market value of the Ore Common Stock on the date of the      grant, exercisable in full on the first anniversary of the date of grant      and exercisable for 90 days from the date of the termination of this      Consulting Agreement.. |
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| c.   | Consultant      will also be reimbursed for all reasonable and necessary out-of-pocket      expenses (including travel, lodging, and the like), which are incurred at      the request of and approved in writing in  advance by      Ore,  provided any travel expenses comply with Ore’s travel      policy, a copy of which is available upon  request. |
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| 4.   | Confidentiality.   In      view of Ore's proprietary rights and interests concerning its Business,      Consultant agrees that during the term of this Agreement and any      subsequent extension(s) thereto and for a period of five (5) years      thereafter, Consultant agrees to keep strictly confidential and not use      for his own benefit or for the benefit of any third party any information      which he may acquire relating to Ore’s business, whether such information      is disclosed or made known by Ore to Consultant or is generated by      Consultant in the course of performing the services      hereunder.   By way of illustration and not limitation,      such shall include all information, communicated by any means, relating to      the business of Ore that is not available to the general public, including      its technical and business information, assets, inventions, know-how,      research programs, biological materials, processes, drug compound      hypotheses, designs, trade secrets, contracts, improvements, discoveries,      databases, software programs, development tools, budgets and unpublished      financial information, licenses, and other data, both technical and      non-technical, prospects, protocols, and other information associated with      this Agreement. |
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| a.   | is      or later becomes generally available to the public by use publication or      the like, through no fault ofConsultant; |
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| b.   | is      obtained from a third party who had the legal right to disclose the same      to Consultant and who is not under an obligation of confidentiality to      Ore; or |
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| c.   | Consultant      already possesses, as evidenced by written records, predating receipt      thereof from Ore provided that this exception shall not apply to any      information received or developed by Consultant during his prior      employment by Ore or as a Director of ore to the extent that such      information subsequently became the property of Ore and was confidential      at the time it became the property ofOre. |
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| 5.   | New      Developments.   Consultant agrees that any      information, including but not limited to discoveries, inventions,      innovations, suggestions, know-how, ideas and reports made by Consultant      which either results from information disclosed by Ore, or is developed as      a result of Consultant's services under this Agreement (“New      Developments”), shall become the sole property of Ore without further      compensation to Consultant and shall be promptly disclosed to      Ore.  Consultant will treat such new developments as information      which is subject to the confidentiality provisions of Paragraph 3      herein.  Ore shall own all right, title and interest in and to      all New Developments under thisAgreement. |
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| 6.   | Patent      Rights and Licenses.   If patentable subject matter      results from services provided hereunder, Consultant shall assist Ore in      the preparation and prosecution of appropriate patent applications and      shall without further compensation execute appropriate documents      acknowledging the assignment of his rights in such subject matter and      applications to Ore.   All expenses incidental to the      filing and prosecution of any such patent applications shall be borne by      Ore.  The disclosure of proprietary information by Ore to      Consultant shall not result in any obligation to grant Consultant any      rights in and to said proprietary subject  matter. |
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| 7.   | Third-Party      Confidential Information.   Consultant agrees that      during the term of this Agreement, he will not disclose to Ore any      information that is confidential or proprietary to any third      party. |
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| 8.   | Non-Compete/Non-Solicitation.   While      this Agreement is in effect and for one year after this Agreement ends,      Consultant agrees that he will not assist third parties to develop, market      or sell products which would compete in the marketplace with Ore’s      products of which Consultant is made aware in the course of his      consulting.  Consultant further agrees that, during the term of      this Agreement and for one (1) year after the date of termination of the      Agreement regardless of the reason for termination, Consultant will not      induce or solicit any employee of Ore to leave the employ of Ore or assist      any third party to do so. |
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| 9.   | Term      and Termination.   This Agreement shall be effective      for a twelve-month period beginning as of the date hereof , and may be      extended in writing by mutual consent of the parties.  However,      either party may terminate this Agreement at any time upon sixty (60)      days' prior written notice, but in no event may this agreement be      terminated prior to the date that is one year from the date of this      Agreement .  Any rights or obligations set forth herein which      are accrued prior to the termination of this Agreement as well as any      sections intended by their nature to survive, including but not limited to      Sections 4, 5, 6 and 8, shall survive termination or expiration of this      Agreement.   Upon termination or expiration of this      Agreement, Consultant shall promptly return to Ore all Ore documentation,      property, data and related information, along with any copies      thereof. |
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| 10.   | Other      Employment.              Consultant is a Managing Director with Pearl Street Venture Funds (“Pearl      Street”), and has and will continue to have substantial duties to Pearl      Street (including its portfolio companies).  Consultant confirms      that he has determined that Pearl Street will not object to the services      to be provided hereunder. |
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| 11.   | Miscellaneous: |
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| a.   | Independent      Contractor.   For the purposes of this Agreement,      Consultant shall be an independent contractor without the authority to      bind or act as agent for Ore or its employees for any      purpose.  All taxes and social security payments due with      respect to any compensation paid pursuant to this Agreement shall be the      sole responsibility of Consultant. |
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| b.   | Assignment.   This      Agreement is a contract for personal services by Consultant in recognition      of his special expertise and experience; the performance of such personal      services may not be assigned ordelegated. |
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| c.   | Governing Law. This Agreement      shall be construed in accordance with the laws of the State of      Maryland.  Consultant hereby expressly consents to the personal      jurisdiction of the state and federal courts located in Maryland for any      lawsuit filed there against him/her by Ore arising from or relating to      this Agreement |
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| d.   | Warranties.   The      parties warrant and represent that they have the right to enter into this      Agreement.   Consultant further warrants and represents      that the terms of this Agreement are not inconsistent with other      contractual obligations, express or implied, which he may      have. |
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| e.   | Amendments.   No      modification to this Agreement shall be effective unless made in writing      and duly executed by or on behalf of eachparty. |
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| f.   | Entire      Agreement.   This Agreement constitutes the entire      agreement between the parties with respect to the services to be provided      by Consultant hereunder superseding all prior agreements and      understandings between the parties (whether written or oral) relating to      said subject matter. However, this Agreement does not modify, waive or      alter any of the obligations of the parties under prior agreements      relating to the previous employment of Consultant by  Ore. |
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| g.   | Counterparts.   This      Agreement may be executed in two or more counterparts, including by      facsimile transmission, each of which shall be deemed an original, but all      of which together shall constitute one and the same      instrument. |
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| Ore      Pharmaceuticals Inc. |                               | Michael      J. Brennan |
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| By:                           | /s/      Mark J. Gabrielson        |                    |   | /s/      Michael J. Brennan |
|                          | Mark      J. Gabrielson, President |                    |   |   |
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