[Federal Register Volume 65, Number 76 (Wednesday, April 19, 2000)]
[Notices]
[Pages 21004-21005]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 00-9810]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

Public Health Service


National Toxicology Program; National Toxicology Program (NTP) 
Board of Scientific Counselors Technical Reports Review Subcommittee 
Meeting; Review of Draft NTP Technical Reports

    Pursuant to Public Law 92-463, notice is hereby given of the next 
meeting of the NTP Board of Scientific Counselors Technical Reports 
Review Subcommittee on May 18, 2000 in the Rodbell Auditorium, Building 
101, South Campus, National Institute of Environmental Health Sciences 
(NIEHS), 111 Alexander Drive, Research Triangle Park, North Carolina. 
The meeting will begin at 8:30 a.m. on May 18 and is open to the 
public. The primary agenda topic is the peer review of draft Technical 
Reports of long-term toxicology and carcinogenesis studies from the 
NTP. There will also be a presentation about the beneficial effects of 
the NIH2000 diet in chronic studies.
    Tentatively scheduled for peer review on May 18 are draft Technical 
Reports of six two-year studies, listed alphabetically in the attached 
table, along with supporting material. Studies were conducted using 
Fischer 344 rats and/or B6C3F<INF>1</INF> mice. The tentative order of 
review is given in the far right column of the table.

Draft Reports Available for Public Review and Comment

    Approximately one month prior to the meeting, the draft reports 
will be available for public review and comment on the Internet free of 
charge through the Environmental Health Information Service (EHIS) at 
http://ehis.niehs.nih.gov. Printed copies can be obtained, as 
available, from: Central Data Management, NIEHS, PO Box 12233 MD E1-02, 
Research Triangle Park, NC 27709, T: 919-541-3419, FAX: 919-541-3687, 
or email: <a href="/cdn-cgi/l/email-protection#5a191e171a34333f322974343332743d352c"><span class="__cf_email__" data-cfemail="eba8afa6ab85828e8398c5858283c58c849d">[email protected]</span></a>.
    The NTP Board of Scientific Counselors Technical Reports Review 
Subcommittee meeting is open to the public and public comment on any of 
the Technical Reports is welcome. Time will be provided for public 
comment on each of the reports under review. In order to facilitate 
planning for the meeting, persons requesting time for an oral 
presentation on a particular Technical Report are asked to notify the 
Executive Secretary, Dr. Mary S. Wolfe (PO Box 12233, MD A3-07, 
Research Triangle Park, NC 27709; telephone 919/541-3971; FAX 919/541-
0295; email <a href="/cdn-cgi/l/email-protection#2651494a404366484f434e5508484f4e08414950"><span class="__cf_email__" data-cfemail="2e594142484b6e40474b465d0040474600494158">[email protected]</span></a>). Persons registering to make comments 
are asked to provide, if possible, a written copy of their statement by 
May 12th to enable review by the Subcommittee and staff prior to the 
meeting. Written statements can supplement and may expand the oral 
presentation, and each speaker is asked to provide his/her name, 
affiliation, mailing address, phone, fax, e-mail and supporting 
organization (if any). At least seven minutes will be allotted to each 
speaker, and if time permits, may be extended to 10 minutes. 
Registration for making public comments will also be available on-site. 
If registering on-site to speak and reading oral comments from printed 
copy, the speaker is asked to bring 25 copies of the text. These copies 
will be distributed to the Chair and Subcommittee members and 
supplement the record.
    Written comments, in lieu of making oral comments, are also 
welcome. The comments should include name, affiliation, mailing 
address, phone, fax, e-mail and sponsoring organization (if any) and 
preferably be received by May 12th to enable review by the Subcommittee 
and staff prior to the meeting.

Request for Additional Information

    The NTP would welcome receiving toxicology and carcinogenesis 
information from completed, ongoing, or planned studies as well as 
current production data, human exposure information, and use patterns 
for any of the chemicals listed in this announcement. Please forward 
this information to Central Data Management at the address given above 
who will relay it to the appropriate staff scientist.
    The agenda and a roster of Subcommittee members will be available 
prior to the meeting on the NTP web homepage at http://ntp-server.niehs.nih.gov and upon request from the Executive Secretary. 
Following the meeting, summary minutes will be available on the NTP web 
homepage and upon request to Dr. Wolfe.

Attachment

    Dated: April 11, 2000.
Samuel H. Wilson,
Deputy Director, National Institute of Environmental Health Sciences.

[[Page 21005]]



 Technical Reports Tentatively Scheduled for Review by the NTP Board of Scientific Counselors Technical Reports
                                       Review Subcommittee on May 18, 2000
----------------------------------------------------------------------------------------------------------------
                                                                                 Route and exposure     Review
        Chemical CAS No.                 Report  No.            Primary uses           levels           order
----------------------------------------------------------------------------------------------------------------
Chloral Hydrate 302-17-0........  TR-502                    The primary          Gavage (water                 4
                                                             sedative used in     vehicle) Mice: 0,
                                                             children.            25, 50, or 100 mg/
                                                                                  kg.
Chloral Hydrate (feed             TR-503                    The primary          Gavage (water                 5
 restricted) 302-17-0.                                       sedative used in     vehicle; feed
                                                             children.            restriction
                                                                                  study) Male Mice:
                                                                                  0, 25, 50, or 100
                                                                                  mg/kg.
p,p'-Dichlorodiphenyl Sulfone 80- TR-501                    Starting product in  Feed Male Rats: 0,            6
 07-9.                                                       production of        10, 30, or 100
                                                             polysulfones and     ppm; Female Rats
                                                             polyethersulfones;   & Mice: 0, 30,
                                                             by-product of        100, or 300 ppm.
                                                             pesticide
                                                             production.
Indium Phosphide 22398-80-7.....  TR-499                    Used in making       Inhalation Rats &             1
                                                             semiconductors,      Mice: 0, 0.03,
                                                             lasers, solar        0.1, or 0.3 mg/m
                                                             cells, and           \3\.
                                                             photodiodes.
Naphthalene 91-20-3.............  TR-500                    Ingredient in moth   Inhalation Rats:              2
                                                             repellants and       0, 10, 30, or 60
                                                             toilet bowl          ppm.
                                                             deodorants and as
                                                             an intermediate in
                                                             a variety of
                                                             chemical synthesis
                                                             processes.
Sodium Nitrite 7632-00-0........  TR-495                    Color fixative and   Drinking water                3
                                                             preservative in      Rats & Mice: 0,
                                                             meats and fish;      750, 1500, or
                                                             also used in a       3000 ppm.
                                                             variety of
                                                             industrial
                                                             processes.
----------------------------------------------------------------------------------------------------------------

[FR Doc. 00-9810 Filed 4-18-00; 8:45 am]
BILLING CODE 4140-01-P


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