**Exhibit 12.1****CERTIFICATIONS**I, Gearóid M. Faherty, certify that:1. I have reviewed this Annual Report on Form 20-F of Eurand N.V.;2. Based on my knowledge, this Annual Report does not contain any untrue statement of a materialfact or omit to state a material fact necessary to make the statements made, in light of thecircumstances under which such statements were made, not misleading with respect to the periodcovered by this Annual Report;3. Based on my knowledge, the consolidated financial statements, and other financial informationincluded in this Annual Report, fairly present in all material respects the financial condition,results of operations and cash flows of Eurand N.V. as of, and for, the periods presented in thisAnnual Report;4. Eurand N.V.’s other certifying officer and I are responsible for establishing and maintainingdisclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) andinternal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and15d-15(f)) for the company and have:     (a) designed such disclosure controls and procedures, or caused such disclosure controls andprocedures to be designed under our supervision, to ensure that material information relating toEurand N.V., including its consolidated subsidiaries, is made known to us by others within thoseentities, particularly during the period in which this Annual Report is being prepared;     (b) designed such internal control over financial reporting, or caused such internal controlover financial reporting to be designed under our supervision, to provide reasonable assuranceregarding the reliability of financial reporting and the preparation of the consolidated financialstatements for external purposes in accordance with generally accepted accounting principles;     (c) evaluated the effectiveness of Eurand N.V.’s disclosure controls and procedures andpresented in this report our conclusions about the effectiveness of the disclosure controls andprocedures, as of the end of the period covered by this report based on such evaluation; andpresented in this Annual Report our conclusions about the effectiveness of the disclosure controlsand procedures based on our evaluation as of the Evaluation Date;     (d) disclosed in this report any change in Eurand N.V.’s internal control over financialreporting that occurred during the period covered by the Annual Report that has materiallyaffected, or is reasonably likely to materially affect, the company’s internal control overfinancial reporting; and5. Eurand N.V.’s other certifying officer and I have disclosed, based on our most recentevaluation of internal control over financial reporting which are reasonably likely to adverselyaffect the company’s ability to record, process, summarize and report financial information; and     (a) all significant deficiencies and material weaknesses in the design or operation ofinternal control over financial reporting which are reasonably likely to adversely affect EurandN.V.’s ability to record, process, summarize and report financial information; and     (b) any fraud, whether or not material, that involves management or other employees who have asignificant role in Eurand N.V.’s internal control over financial reporting.Date: March 31, 2008   /s/ Gearóid M. Faherty Gearóid M. Faherty       Chief Executive Officer