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Exhibit 10.7

 

FIRST AMENDMENT TO

DARTMOUTH — PHYTOMEDICAL TECHNOLOGIES, INC. RESEARCH 

AGREEMENT

            THIS FIRST AMENDMENT AGREEMENT ("Amendment') is entered into as July 10th, 2007, by and between the TRUSTIES OF DARTMOUTH COLLEGE, a non-profit educational and research institution existing under the laws of the State of New Hampshire (-hereinafter "Dartmouth") and PHYTOMEDICAL TECHNOLOGIES, INC. a Corporation of the State of Nevada (hereinafter "Phytomedical").



WHEREAS, the parties previously entered into that certain Research Agreement dated June I, 2007, (the "Agreement"): and

WHEREAS, the parties desire to amend such Agreement as further set forth herein;

NOW, THEREFORE, in consideration of the premises and the covenants herein contained, the parties hereby agree. to amend the Agreement as follows:

In Section 9. Contract Period: The "Contract Period" shall mean the period commencing on the Effective Date and ending on October I, 2008.

In Section 10. Research Support, the following shall be added:

Phytomedical shall pay Dartmouth additional research support in the amount of 55,000 designated for payment to the. California Pacific Medical Center Research Institute (CPMCR1) to test the Bis(9-Aminoacridine) compounds, which are the subject of the aforementioned Research Agreement, in certain assays available through CPMCR1 and its investigator Dr. Lixi Yang_

In Section IS. Payments;

As of the effective date of this amendment, the remaining three (3) quarterly payments will he suspended until October 1, 2007 and will be paid quarterly from October 1, 2007 thereafter.

            All other terms and conditions shall remain the same.






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IN WITNESS WREHEOF, the parties have duly executed this Amendment as of the date written above:

 


	
PHYTOMEDICAL, INC

	
TRUSTEES OF DARTMOUTH COLLEGE


	
 

	
 

	
 

	
 


	
By:

Title:

	
/s/Greg Wujek

President, CEO

	
By:

Title

	




 

	
/s/Alla Kan

Alla Kan Director Technology Transfer Office

	
 


	
Date:

	
7-11-07

	
Date

	
7-11-07


						



 

                                                                                                                                              

 


 

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SECOND AMENDMENT TO 

DARTMOUTH — PHYTOMEDICAL TECHNOLOGIES, INC. RESEARCH 

AGREEMENT

THIS SECOND AMENDMENT AGREEMENT ("Amendment") is entered into as November 13, 2007, by and between the TRUSTEES OF DARTMOUTH COLLEGE, a non­profit educational and research institution existing under the laws of the State of New Hampshire (hereinafter "Dartmouth") and PHYTOMEDICAL TECHNOLOGIES, INC. a Corporation of the State of Nevada (hereinafter "Phytomedical").

WHEREAS, the parties previously entered into that certain Research Agreement dated June 1, 2007, (the "Agreement"); and a First Amendment dated July 10, 2007.

WHEREAS, the parties desire to amend such Agreement as further set forth herein;

NOW, THEREFORE, in consideration of the premises and the covenants herein contained, the parties hereby agree to amend the Agreement as follows:

In Section 10. Research Support, the following shall be added:

Phytomedical shall pay Dartmouth additional research support in the amount of $12,000 designated for payment to the California Pacific Medical Center Research Institute (CPMCRI) to test the Bis(9-Aminoacridine) compounds, which are the subject of the aforementioned Research Agreement, in certain assays available through CPMCRI and its investigator Dr. Lixi Yang.

All other terms and conditions shall remain the same.

IN WITNESS WHEREOF, the parties have duly executed this Amendment as of the date first written above:

                                                                                                                                                                                                     

 


	
PHYTOMEDICAL, INC

	
TRUSTEES OF DARTMOUTH COLLEGE


	
 

	
 

	
 

	
 


	
By:

Title:

	
/s/Greg Wujek

Greg Wujek

President, CEO

	
By:

Title

	






	
______________

______________

	
 


	
Date:

	
11-13-07

	
Date

	
______________


						



 


 

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THIRD AMENDMENT TO

DARTMOUTH — PHYTOMEDICAL TECHNOLOGIES, INC. RESEARCH

AGREEMENT

THIS THIRD AMENDMENT AGREEMENT ("Amendment") is entered into as of November 26, 2007, by and between the TRUSTEES OF DARTMOUTH COLLEGE, a non­profit educational and research institution existing under the laws of the State of New Hampshire (hereinafter "Dartmouth") and PHYTOMEDICAL TECHNOLOGIES, INC. a Corporation of the State of Nevada (hereinafter "Phytomedical").

WHEREAS, the parties previously entered into that certain Research Agreement dated June 1, 2007, (the "Agreement"); a First Amendment dated July 10, 2007; and a Second Amendment dated November 13, 2007.

WHEREAS, the parties desire to amend such Agreement as further set forth herein;

NOW, THEREFORE, in consideration of the premises and the covenants herein contained, the parties hereby agree to amend the Agreement as follows:

In Section 10. Research Support, the following shall be added:

Phytomedical shall pay Dartmouth additional research support in the amount of $6,000 designated for payment to the California Pacific Medical Center Research Institute (CPMCRI) to test the Bis(9-Aminoacridine) compounds, which are the subject of the aforementioned Research Agreement, in certain assays available through CPMCRI and its investigator Dr. Lixi Yang.

All other terms and conditions shall remain the same.

IN WITNESS WHEREOF, the parties have duly executed this Amendment as of the date first written above:





	
PHYTOMEDICAL, INC

	
TRUSTEES OF DARTMOUTH COLLEGE


	
 

	
 

	
 

	
 


	
By:

Title:

	
/s/Greg Wujek

President, CEO

	
By:

Title

	




 

	
/s/Alla Kan

Alla Kan Director Technology Transfer Office

	
 


	
Date:

	
12-5-7

	
Date

	
12-4-07


						


 


 

Page 1 of 1






FOURTH AMENDMENT TO

DARTMOUTH — PHYTOMEDICAL TECHNOLOGIES, INC. RESEARCH

AGREEMENT

THIS FOURTH AMENDMENT AGREEMENT ("Amendment") is entered into as of March 14, 2008, by and between the TRUSTEES OF DARTMOUTH COLLEGE, a non­profit educational and research institution existing under the laws of the State of New Hampshire (hereinafter "Dartmouth") and PHYTOMEDICAL TECHNOLOGIES, INC. a Corporation of the State of Nevada (hereinafter "Phytomedical").

WHEREAS, the parties previously entered into that certain Research Agreement dated June 1, 2007, (the "Agreement"); a First Amendment dated July 10, 2007; and a Second Amendment dated November 13, 2007; and a Third Amendment dated November 26, 2007.

WHEREAS, the parties desire to amend such Agreement as further set forth herein;

NOW, THEREFORE, in consideration of the premises and the covenants herein contained, the parties hereby agree to amend the Agreement as follows:

In Section 10. Research Support, the following shall be added:

Phytomedical shall pay Dartmouth additional research support in the amount of $80,800 designated for payment to the California Pacific Medical Center Research Institute (CPMCRI) to test the Bis(9-Aminoacridine) compounds, which are the subject of the aforementioned Research Agreement, in certain assays available through CPMCRI and its investigator Dr. Lixi Yang.

All other terms and conditions shall remain the same.

IN WITNESS WHEREOF, the parties have duly executed this Amendment as of the date first written above:





	
PHYTOMEDICAL, INC

	
TRUSTEES OF DARTMOUTH COLLEGE


	
 

	
 

	
 

	
 


	
By:

Title:

	
/s/Greg Wujek

President, CEO

	
By:

Title

	




 

	
/s/Alla Kan

Alla Kan Director Technology Transfer Office

	
 


	
Date:

	
3-14-08

	
Date

	
March 17, 2008


						


 

 


 

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FIFTH AMENDMENT TO 

DARTMOUTH — PHYTOMEDICAL TECHNOLOGIES, INC. RESEARCH 

AGREEMENT

THIS FIFTH AMENDMENT AGREEMENT ("Amendment") is entered into as of March 20, 2008, by and between the TRUSTEES OF DARTMOUTH COLLEGE, a non­profit educational and research institution existing under the laws of the State of New Hampshire (hereinafter "Dartmouth") and PHYTOMEDICAL TECHNOLOGIES, INC. a Corporation of the State of Nevada (hereinafter "Phytomedical").

WHEREAS, the parties previously entered into that certain Research Agreement dated June 1, 2007, (the "Agreement"); a First Amendment dated July 10, 2007; a Second Amendment dated November 13, 2007; a Third Amendment dated November 26, 2007, and a Fourth Amendment dated March 14, 2008.

WHEREAS, the parties desire to amend such Agreement as further set forth herein;

NOW, THEREFORE, in consideration of the premises and the covenants herein contained, the parties hereby agree to amend the Agreement as follows:

In Section 10. Research Support, shall be amended to read as follows:

Phytomedical shall pay Dartmouth additional research support in the amount of $80,800 designated for payment to the California Pacific Medical Center Research Institute (CPMCRI) to test the Bis(9-Aminoacridine), Bis-Pyridocarbazole and Bis-Carbazole compounds, which are the subject of the aforementioned Research Agreement, in certain assays available through CPMCRI and its investigator Dr. Lixi Yang.

All other terms and conditions shall remain the same.

IN WITNESS WHEREOF, the parties have duly executed this Amendment as of the date first written above:

 

	
PHYTOMEDICAL, INC

	
TRUSTEES OF DARTMOUTH COLLEGE


	
 

	
 

	
 

	
 


	
By:

Title:

	
                              

                             

 

	
By:

Title

	




 

	
/s/Alla Kan

Alla Kan Director Technology Transfer Office

	
 


	
Date:

	
                            

	
Date

	
March 20, 2009


						


 


 

Page 1 of 1






SIXTH AMENDMENT TO

DARTMOUTH — PHYTOMEDICAL TECHNOLOGIES, INC. RESEARCH

AGREEMENT

THIS SIXTH AMENDMENT AGREEMENT ("Amendment") is entered into as of October 1, 2008, by and between the TRUSTEES OF DARTMOUTH COLLEGE, a non­profit educational and research institution existing under the laws of the State of New Hampshire (hereinafter "Daitinouth") and PHYTOMEDICAL TECHNOLOGIES, INC. a Corporation of the State of Nevada (hereinafter "Phytomedical").

WHEREAS, the parties previously entered into that certain Research Agreement dated June 1, 2007, (the "Agreement"); a First Amendment dated July 10, 2007; a Second Amendment dated November 13, 2007; a Third Amendment dated November 26, 2007; a Fourth Amendment dated March 14, 2008; and A Fifth Amendment dated March 20, 2008.

WHEREAS, the parties desire to amend such Agreement as further set forth herein;

NOW, THEREFORE, in consideration of the premises and the covenants herein contained, the parties hereby agree to amend the Agreement as follows:

In Section 9. Contract Period, shall be amended to read:

The "Contract Period" shall mean the period commencing on the Effective Date and ending on September 30, 2009.

In Section 10. Research Support, the following shall be added:

PHYTOMEDICAL shall provide additional research support to Dartmouth for laboratory research at a level of $47,000 for the Contract Period in accordance with the attached budget, which makes up Attachment C, and the attached Research Plan which makes up Attachment D.

In Section 18. Payments, the following shall be added:

As per this Sixth Amendment, the additional $47,000, as defined in the amended Section 10, will be paid quarterly from October 1, 2008, the first to be due on October 1, 2008 and every three months thereafter. Subsequent payments after the initial payment will be due within 30 days of PHYTOMEDICAL's receipt of Dartmouth's invoice.





All other terms and conditions shall remain the same.


Page 1 of 2






IN WITNESS WHEREOF, the parties have duly executed this Amendment as of the date first written above:

	
PHYTOMEDICAL, INC

	
TRUSTEES OF DARTMOUTH COLLEGE


	
 

	
 

	
 

	
 


	
By:

Title:

	
/s/Greg Wujek

President, CEO

	
By:

Title

	




 

	
/s/Alla Kan

Alla Kan Director Technology Transfer Office

	
 


	
Date:

	
10-1-08

	
Date

	
Sept. 24, 2008


						


 


 

Page 2 of 2






SEVENTH AMENDMENT TO 

DARTMOUTH — PHYTOMEDICAL TECHNOLOGIES, INC. RESEARCH 

AGREEMENT

THIS SEVENTH AMENDMENT AGREEMENT ("Amendment") is entered into as of February 26, 2009, by and between the TRUSTEES OF DARTMOUTH COLLEGE, a non­profit educational and research institution existing under the laws of the State of New Hampshire (hereinafter "Dartmouth") and PHYTOMEDICAL TECHNOLOGIES, INC. a Corporation of the State of Nevada (hereinafter "Phytomedical").

WHEREAS, the parties previously entered into that certain Research Agreement dated June 1, 2007, (the "Agreement"); Amended on July 10, 2007, November 13, 2007, November 26, 2007, March 14, 2008, March 20, 2008, and October 1, 2008.

WHEREAS, the parties desire to amend such Agreement as further set forth herein;

NOW, THEREFORE, in consideration of the premises and the covenants herein contained, the parties hereby agree to amend the Agreement as follows:

In Section 10. Research Support, the following shall be added:

Phytomedical shall pay Dartmouth additional research support in the amount of $18,960 designated for payment to the California Pacific Medical Center Research Institute (CPMCRI) to test the Bis-Acridine, Bis-pyridocarbazole and Bis-carbazole Antitumor Compounds, which are the subject of the aforementioned Research Agreement, in certain assays available through CPMCRI and its investigator Dr. Lixi Yang.

All other terms and conditions shall remain the same.

IN WITNESS WHEREOF, the parties have duly executed this Amendment as of the date first written above:

 

	
PHYTOMEDICAL, INC

	
TRUSTEES OF DARTMOUTH COLLEGE


	
 

	
 

	
 

	
 


	
By:

Title:

	
/s/Greg Wujek

Greg Wujek President, CEO

	
By:

Title

	




 

	
/s/Alla Kan

Alla Kan Director Technology Transfer Office

	
 


	
Date:

	
3-2-09

	
Date

	
2-26-09


						


 


 

Page 1 of 1






EIGHTH AMENDMENT TO 

DARTMOUTH — PHYTOMEDICAL TECHNOLOGIES, INC. RESEARCH 

AGREEMENT

THIS EIGHTH AMENDMENT AGREEMENT ("Amendment") is entered into as of May 26, 2009, by and between the TRUSTEES OF DARTMOUTH COLLEGE, a non-profit educational and research institution existing under the laws of the State of New Hampshire (hereinafter "Dartmouth") and PHYTOMEDICAL TECHNOLOGIES, INC. a Corporation of the State of Nevada (hereinafter "Phytomedical").

WHEREAS, the parties previously entered into that certain Research Agreement dated June 1, 2007, (the "Agreement"); Amended on July 10, 2007, November 13, 2007, November 26, 2007, March 14, 2008, March 20, 2008, October 1, 2008, and February 26, 2009.

WHEREAS, the parties desire to amend such Agreement as further set forth herein;

NOW, THEREFORE, in consideration of the premises and the covenants herein contained, the parties hereby agree to amend the Agreement as follows:

In Section 10. Research Support, the following shall be added:

Phytomedical shall pay Dartmouth additional research support in the amount of $5,000 designated for payment to the California Pacific Medical Center Research Institute (CPMCRI) to test the Bis-Acridine, Bis-pyridocarbazole and Bis-carbazole Antitumor Compounds, which are the subject of the aforementioned Research Agreement, in certain assays available through CPMCRI and its investigator Dr. Lixi Yang.

All other terms and conditions shall remain the same.

IN WITNESS WHEREOF, the parties have duly executed this Amendment as of the date first written above:

	
PHYTOMEDICAL, INC

	
TRUSTEES OF DARTMOUTH COLLEGE


	
 

	
 

	
 

	
 


	
By:

Title:

	
/s/Greg Wujek

Greg Wujek President, CEO

	
By:

Title

	




 

	
/s/Alla Kan

Alla Kan Director Technology Transfer Office

	
 


	
Date:

	
5-27-09

	
Date

	
5-27-09


						


 

 

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