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# EXHIBIT 12.1

# CERTIFICATION

I, Izhak Tamir certify
that:

| | 1. | I have reviewed this annual report on Form 20-F of Tikcro Technologies Ltd.:
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| | 2. | Based on my knowledge, this report does not contain any untrue statement of a
               material fact or omit to state a material fact necessary to make the statements
               made, in light of the circumstances under which such statements were made, not
               misleading with respect to the period covered by this report;
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| | 3. | Based on my knowledge, the financial statements, and other financial information
               included in this report, fairly present in all material respects the financial
               condition, results of operations and cash flows of the company as of, and for,
               the periods presented in this report;
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| | 4. | I am responsible for establishing and maintaining disclosure controls and
               procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) for the
               company and have:
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| | a. | designed such disclosure controls and procedures, or caused such disclosure
          controls and procedures to be designed under my supervision, to ensure that
          material information relating to the company, including its consolidated
          subsidiaries, is made known to me by others within those entities, particularly
          during the period in which this report is being prepared;
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| | b. | evaluated the effectiveness of the companys disclosure controls and
          procedures and presented in this report my conclusions about the effectiveness
          of the disclosure controls and procedures, as of the end of the period covered
          by this report based on such evaluation; and
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| | c. | disclosed in this report any change in the companys internal control over
          financial reporting that occurred during the period covered by the annual report
          that has materially affected, or is reasonably likely to materially affect, the
          companys internal control over financial reporting; and
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| | 5. | I have disclosed, based on our most recent evaluation of internal control over
               financial reporting, to the companys auditors and the audit committee of
               the companys board of directors (or persons performing the equivalent
               functions):
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| | a. | all significant deficiencies and material weaknesses in the design or operation
          of internal control over financial reporting which are reasonably likely to
          adversely affect the companys ability to record, process, summarize and
          report financial information; and
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| | b. | any fraud, whether or not material, that involves management or other employees
          who have a significant role in the companys internal control over
          financial reporting.
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|Dated: June 27, 2005 |  | /S/ Izhak Tamir
Izhak TamirPrincipal Executive Officer andPrincipal Financial Officer
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