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Exhibit 12.1

Certification of Principal Executive Officer pursuant to 17 CFR 240.13a-14(a),
as adopted pursuant to §302 of the Sarbanes-Oxley Act

I, Aviv Boim, certify
that:

| | 1. | I have reviewed this annual report on Form 20-F of Tikcro Technologies Ltd.;
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| | 2. | Based on my knowledge, this report does not contain any untrue statement of a
               material fact or omit to state a material fact necessary to make the statements
               made, in light of the circumstances under which such statements were made, not
               misleading with respect to the period covered by this report;
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| | 3. | Based on my knowledge, the financial statements, and other financial information
               included in this report, fairly present in all material respects the financial
               condition, results of operations and cash flows of the company as of, and for,
               the periods presented in this report;
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| | 4. | I am responsible for establishing and maintaining disclosure controls and
               procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and
               internal control over financial reporting (as defined in Exchange Act Rules
               13a-15(f) and 15d  15(f)) for the company and have:
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| | (a) | Designed such disclosure controls and procedures, or caused such disclosure
                    controls and procedures to be designed under my supervision, to ensure that
                    material information relating to the company is made known to me, particularly
                    during the period in which this report is being prepared;
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| | (b) | Designed such internal control over financial reporting, or caused such internal
                    control over financial reporting to be designed under my supervision, to provide
                    reasonable assurance regarding the reliability of financial reporting and the
                    preparation of financial statements for external purposes in accordance with
                    generally accepted accounting principles;
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| | (c) | Evaluated the effectiveness of the companys disclosure controls and
                    procedures and presented in this report my conclusions about the effectiveness
                    of the disclosure controls and procedures, as of the end of the period covered
                    by this report based on such evaluation; and
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| | (d) | Disclosed in this report any change in the companys internal control over
                    financial reporting that occurred during the period covered by the annual report
                    that has materially affected, or is reasonably likely to materially affect, the
                    companys internal control over financial reporting; and
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| | 5. | I have disclosed, based on my most recent evaluation of internal control over
               financial reporting, to the companys auditors and the audit committee of
               the companys board of directors (or persons performing the equivalent
               functions):
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| | (a) | All significant deficiencies and material weaknesses in the design or operation
                    of internal control over financial reporting which are reasonably likely to
                    adversely affect the companys ability to record, process, summarize and
                    report financial information; and
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| | (b) | Any fraud, whether or not material, that involves management or other employees
                    who have a significant role in the companys internal control over
                    financial reporting.
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Date: June 26, 2008

| |  | By: /s/ Aviv Boim
Aviv BoimPrincipal Executive Officer andPrincipal Financial Officer
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