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Exhibit 12.1

Certification
of Principal Executive Officer and Principal Financial Officer pursuant to 17 CFR 240.13a-14(a), as
adopted pursuant to §302 of the Sarbanes-Oxley Act

I, Eric Paneth, certify that:

| | 1. | I
have reviewed this annual report on Form 20-F of Tikcro Technologies Ltd.;
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| | 2. | Based
on my knowledge, this report does not contain any untrue statement of a
               material fact or omit to state a material fact necessary to make the
statements                made, in light of the circumstances under which such statements
were made, not                misleading with respect to the period covered by this
report;
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| | 3. | Based
on my knowledge, the financial statements, and other financial information
               included in this report, fairly present in all material respects the
financial                condition, results of operations and cash flows of the company
as of, and for,                the periods presented in this report;
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| | 4. | I
am responsible for establishing and maintaining disclosure controls and
               procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and
               internal control over financial reporting (as defined in Exchange Act
Rules                13a-15(f) and 15d  15(f)) for the company and have:
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| | (a) | Designed
such disclosure controls and procedures, or caused such disclosure
                    controls and procedures to be designed under my supervision, to
ensure that                     material information relating to the company is made
known to me, particularly                     during the period in which this report is
being prepared;
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| | (b) | Designed
such internal control over financial reporting, or caused such internal
                    control over financial reporting to be designed under my supervision,
to provide                     reasonable assurance regarding the reliability of
financial reporting and the                     preparation of financial statements for
external purposes in accordance with                     generally accepted accounting
principles;
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| | (c) | Evaluated
the effectiveness of the companys disclosure controls and
                    procedures and presented in this report my conclusions about the
effectiveness                     of the disclosure controls and procedures, as of the
end of the period covered                     by this report based on such evaluation;
and
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| | (d) | Disclosed
in this report any change in the companys internal control over
                    financial reporting that occurred during the period covered by the
annual report                     that has materially affected, or is reasonably likely
to materially affect, the                     companys internal control over
financial reporting; and
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| | 5. | I
have disclosed, based on my most recent evaluation of internal control over
               financial reporting, to the companys auditors and the audit
committee of                the companys board of directors (or persons performing
the equivalent                functions):
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| | (a) | All
significant deficiencies and material weaknesses in the design or operation
                    of internal control over financial reporting which are reasonably
likely to                     adversely affect the companys ability to record,
process, summarize and                     report financial information; and
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| | (b) | Any
fraud, whether or not material, that involves management or other employees
                    who have a significant role in the companys internal control
over                     financial reporting.
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Date: June 29, 2009

| |  | By: /s/ Eric Paneth
Eric Paneth Principal Executive Officer andPrincipal Financial Officer
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