##### Table of Contents

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549



FORM 20-F



(Mark One)



| ̈ | REGISTRATION STATEMENT PURSUANT TO SECTION 12(b) OR (g) OF THE
|- | --------------------------------------------------------------

SECURITIES EXCHANGE ACT OF 1934



OR



|x | ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
|- | ------------------------------------------------------------------------------------



For the fiscal year ended December 31, 2007



OR



| ̈ | TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
|- | ----------------------------------------------------------------------------------------



OR



| ̈ | SHELL COMPANY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE
|- | -----------------------------------------------------------

|SECURITIES | EXCHANGE ACT OF 1934
|---------- | --------------------



Date of event requiring this shell company report



For the transition period from              to



Commission file number: 001-1176629



GPC Biotech AG

(Exact name of Registrant as specified in its charter)

Not Applicable

(Translation of Registrants name into English)

Federal Republic of Germany

(Jurisdiction of incorporation or organization)



Fraunhoferstrasse 20, D-82152 Planegg (Martinsried)/Munich, Germany

(Address of principal executive offices)



Securities registered or to be registered pursuant to Section 12(b) of the Act.





Title of each class

Ordinary Bearer Shares, without par value

American Depositary
Shares (as evidenced

by American Depositary Receipts), each

representing one, Ordinary Bearer Share.



Name of each
exchange on which registered

The Nasdaq Stock Market LLC





Securities registered or to be registered pursuant to Section 12(g) of the Act:

None





(Title of class)





(Title of class)



| |  |                                                                                                                                                                       
| |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------
| |  | Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.



Securities for which there is a
reporting obligation pursuant to Section 15(d) of the Act:

None





(Title of class)



Indicate the number of outstanding shares of each of the issuers classes of
capital or common stock as of the close of the period covered by the annual report. 36,836,853



Indicate by check mark if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act.



x Yes     ̈ No



If this report is an annual or transition report, indicate by check mark if the registrant is not required to file reports pursuant to
Section 13 or 15(d) of the Securities Exchange Act of 1934.



 ̈ Yes    x No



Note  Checking the box above will not
relieve any registrant required to file reports pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 from their obligations under those Sections.



Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities
Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days.



x Yes     ̈ No



Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, or a non-accelerated filer. See
definition of accelerated filer and large accelerated filer in Rule 12b-2 of the Exchange Act. (Check one):



Large accelerated filer x Accelerated filer  ̈ Non-accelerated filer  ̈



Indicate by check mark which basis of accounting the registrant has
used to prepare the financial statements included in this filing:



|            |  |                                                                                                         |  |        
|----------- |  | ------------------------------------------------------------------------------------------------------- |  | -------
|U.S. GAAP x |  | International Financial Reporting Standards as issued by the International Accounting Standards Board  ̈ |  | Other  ̈



If Other has been
checked in response to the previous question, indicate by check mark which financial statement item the registrant has elected to follow.



Item 17  ̈    Item 18  ̈



If this is an annual report, indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the
Exchange Act).



 ̈ Yes    x No



(APPLICABLE ONLY TO ISSUERS INVOLVED IN BANKRUPTCY PROCEEDINGS DURING THE PAST FIVE
YEARS)



Indicate by check mark whether the registrant has filed all
documents and reports required to be filed by Sections 12, 13 or 15(d) of the Securities Exchange Act of 1934 subsequent to the distribution of securities under a plan confirmed by a court.



 ̈ Yes     ̈ No



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##### Table of Contents

TABLE OF CONTENTS



|                                                                                      |  |     
|------------------------------------------------------------------------------------- |  | ----
|                                                                                      | 
|PART I                                                                                |  | Page
|                                                                                      | 
|Item 1: Identity of Directors, Senior Management and Advisers                         |  | 2   
|                                                                                      | 
|Item 2: Offer Statistics and Expected Timetable                                       |  | 2   
|                                                                                      | 
|Item 3: Key Information                                                               |  | 2   
|                                                                                      | 
|Selected Consolidated Financial Data                                                  |  | 3   
|                                                                                      | 
|Item 3B: Capitalization and Indebtedness                                              |  | 4   
|                                                                                      | 
|Item 3C: Reasons for the Offer and Use of Proceeds                                    |  | 4   
|                                                                                      | 
|Item 3D: Risk Factors                                                                 |  | 5   
|                                                                                      | 
|Item 4: Information on the Company                                                    |  | 23  
|                                                                                      | 
|Item 4A: Unresolved Staff Comments                                                    |  | 46  
|                                                                                      | 
|Item 5: Operating and Financial Review and Prospects                                  |  | 47  
|                                                                                      | 
|Item 6: Directors, Senior Management and Employees                                    |  | 67  
|                                                                                      | 
|Item 7: Major Shareholders and Related Party Transactions                             |  | 86  
|                                                                                      | 
|Item 8: Financial Information                                                         |  | 90  
|                                                                                      | 
|Item 9: The Offer and Listing                                                         |  | 92  
|                                                                                      | 
|Item 10: Additional Information                                                       |  | 93  
|                                                                                      | 
|Item 11: Quantitative and Qualitative Disclosures About Market Risk                   |  | 115 
|                                                                                      | 
|Item 12: Description of Securities Other Than Equity Securities                       |  | 116 
|                                                                                      | 
|PART II                                                                               |  |     
|                                                                                      | 
|Item 13: Defaults, Dividend Arrearages and Delinquencies                              |  | 116 
|                                                                                      | 
|Item 14: Material Modifications to the Rights of Security Holders and Use of Proceeds |  | 116 
|                                                                                      | 
|Item 15: Controls and Procedures                                                      |  | 116 
|                                                                                      | 
|Item 16A: Audit Committee Financial Expert                                            |  | 118 
|                                                                                      | 
|Item 16B: Code of Ethics                                                              |  | 118 
|                                                                                      | 
|Item 16C: Principal Accountant Fees and Services                                      |  | 118 
|                                                                                      | 
|Item 16D: Exemptions from the Listing Standards for Audit Committees                  |  | 119 
|                                                                                      | 
|Item 16E: Purchases of Equity Securities by the Issuer and Affiliated Purchasers      |  | 119 
|                                                                                      | 
|PART III                                                                              |  |     
|                                                                                      | 
|Item 17: Financial Statements                                                         |  | 119 
|                                                                                      | 
|Item 18: Financial Statements                                                         |  | 119 
|                                                                                      | 
|Item 19: Exhibits                                                                     |  | 120 



i



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Certain Definitions



In this annual report, references to  are to euro and references
to USD, U.S. $, $, dollars and U.S. dollars are to United States dollars. We publish our financial statements in euro.



In this annual report, unless otherwise provided, references to GPC Biotech, the company, we,
us and our refer to GPC Biotech AG and its wholly owned subsidiary, GPC Biotech Inc.



Forward-looking Statements



This annual
report includes forward-looking statements. Forward-looking statements may be, but are not necessarily, identified by words like believe, anticipate, intend, expect, target,
goal, estimate, plan, assume, may, will, could and similar expressions. Forward-looking statements include, but are not limited to, statements about:



| |  | the timing and ultimate success in obtaining regulatory approval in the U.S., Europe or any other jurisdiction for our lead product candidate, satraplatin, or any of our other product
candidates;
| | - | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  | our estimates regarding anticipated operating losses, future revenues, capital requirements and our needs for additional financing;
| | - | -----------------------------------------------------------------------------------------------------------------------------------



| |  | our ability to execute M&A or in-licensing transactions to successfully expand our pipeline;
| | - | --------------------------------------------------------------------------------------------



| |  | the progress, timing and completion of our research, development and preclinical studies and clinical trials for our product candidates;
| | - | ----------------------------------------------------------------------------------------------------------------------------------------



| |  | our ability to market, commercialize, achieve market acceptance for and sell satraplatin and our other product candidates; and
| | - | ------------------------------------------------------------------------------------------------------------------------------



| |  | our ability to adequately protect our intellectual property and operate our business without infringing upon the intellectual property rights of others;
| | - | --------------------------------------------------------------------------------------------------------------------------------------------------------



We have based these forward-looking statements on our current expectations and
projections about future events. These forward-looking statements are subject to risks, uncertainties and assumptions about us, including those listed in Item 3 of this annual report, Key InformationRisk Factors, starting on
page 6 of this annual report, various sections of Item 4, Information on the Company, Item 5, Operating and Financial Review and Prospects, and elsewhere in this annual report. Other factors, besides those listed
here, could also adversely affect us.



In light of these risks,
uncertainties and assumptions, the forward-looking events discussed in this annual report might not occur. Except as required by law, we do not undertake any obligation to publicly update or revise any forward-looking statements, whether as a result
of new information, future events or otherwise. You are advised, however, to consult any additional disclosures we make in our 6-K reports to the SEC. This discussion is provided as permitted by Section 27A of the Securities Act of 1933, as
amended and Section 21E of the Securities Exchange Act of 1934, as amended.



1



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##### Table of Contents

PART I



Item 1. Identity of Directors, Senior Management and Advisers.



Not applicable.



Item 2. Offer Statistics and Expected Timetable.



Not applicable.



Item 3. Key Information.



2



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##### Table of Contents

SELECTED CONSOLIDATED FINANCIAL DATA



We have derived the selected consolidated financial data presented in the table below
from our audited consolidated financial statements for the years presented.



The following table presents a summary of consolidated financial information of GPC Biotech. We prepare our consolidated financial statements in accordance with accounting principles generally accepted in the United States of America, or
U.S. GAAP. You should read the following summary of consolidated financial information in conjunction with the section of this annual report entitled Operating and Financial Review and Prospects in Item 5 and our consolidated
financial statements and the related notes contained in Item 18 of this annual report.



|                                                                                         |  |                                                                 |            |   |      |   |            |      |  |   |            |   |  |      |            |   |  |   |            |  
|---------------------------------------------------------------------------------------- |  | --------------------------------------------------------------- | ---------- | - | ---- | - | ---------- | ---- |  | - | ---------- | - |  | ---- | ---------- | - |  | - | ---------- | -
|                                                                                         |  | Year ended December 31,                                         |           
|                                                                                         |  | 2007                                                            |            |   | 2006 |   |            | 2005 |  |   | 2004       |   |  | 2003 |           
|                                                                                         |  | (amounts in thousands of euro, except share and per share data) |           
|Statement of operations data:(1)                                                         |  |                                                                 |            |   |      |   |            |      |  |   |            |   |  |      |            |   |  |   |            |  
|Revenues                                                                                 |  |                                                                 | 18,315     |   |      |   | 22,674     |      |  |   | 9,341      |   |  |      | 12,649     |   |  |   | 21,594     |  
|Research and development expenses                                                        |  |                                                                 | 51,437     |   |      |   | 64,707     |      |  |   | 55,684     |   |  |      | 39,955     |   |  |   | 37,535     |  
|Acquired in-process research and development                                             |  |                                                                 |           |   |      |   |           |      |  |   | 683        |   |  |      |           |   |  |   |           |  
|Total operating expenses                                                                 |  |                                                                 | 90,854     |   |      |   | 88,866     |      |  |   | 77,374     |   |  |      | 53,541     |   |  |   | 51,068     |  
|Operating loss                                                                           |  |                                                                 | (72,539    | ) |      |   | (66,192    | )    |  |   | (68,033    | ) |  |      | (40,892    | ) |  |   | (29,474    | )
|Net loss before cumulative effect of change in accounting principle                      |  |                                                                 | (69,245    | ) |      |   | (64,446    | )    |  |   | (62,207    | ) |  |      | (39,927    | ) |  |   | (26,831    | )
|Cumulative effect of change in accounting principle                                      |  |                                                                 |           |   |      |   | 433        |      |  |   |           |   |  |      |           |   |  |   |           |  
|Net loss                                                                                 |  |                                                                 | (69,245    | ) |      |   | (64,013    | )    |  |   | (62,207    | ) |  |      | (39,927    | ) |  |   | (26,831    | )
|Per share data:                                                                          |  |                                                                 |            |   |      |   |            |      |  |   |            |   |  |      |            |   |  |   |            |  
|Basic and diluted loss per share                                                         |  |                                                                | (1.91      | ) |      |  | (1.95      | )    |  |  | (2.08      | ) |  |     | (1.60      | ) |  |  | (1.29      | )
|Shares used in computing basic and diluted loss per share                                |  |                                                                 | 36,181,956 |   |      |   | 32,840,480 |      |  |   | 29,877,348 |   |  |      | 24,950,638 |   |  |   | 20,731,535 |  
|                                                                                         | 
|                                                                                         |  | At December 31,                                                 |           
|                                                                                         |  | 2007                                                            |            |   | 2006 |   |            | 2005 |  |   | 2004       |   |  | 2003 |           
|                                                                                         |  | (amounts in thousands of euro except share data)                |           
|Balance sheet data:                                                                      |  |                                                                 |            |   |      |   |            |      |  |   |            |   |  |      |            |   |  |   |            |  
|Cash and cash equivalents(2)                                                             |  |                                                                 | 49,681     |   |      |   | 38,336     |      |  |   | 30,559     |   |  |      | 59,421     |   |  |   | 34,947     |  
|Marketable securities and short-term investments                                         |  |                                                                 | 14,077     |   |      |   | 57,186     |      |  |   | 63,061     |   |  |      | 69,248     |   |  |   | 54,221     |  
|Total assets                                                                             |  |                                                                 | 73,386     |   |      |   | 107,519    |      |  |   | 139,263    |   |  |      | 141,893    |   |  |   | 101,564    |  
|Long-term debt, including capital lease obligations(3)                                   |  |                                                                 |           |   |      |   |           |      |  |   |           |   |  |      |           |   |  |   | 959        |  
|Ordinary shares                                                                          |  |                                                                 | 36,837     |   |      |   | 33,895     |      |  |   | 30,152     |   |  |      | 28,741     |   |  |   | 20,754     |  
|Subscribed shares                                                                        |  |                                                                 |           |   |      |   | 334        |      |  |   |           |   |  |      |           |   |  |   | 215        |  
|Total shareholders equity                                                               |  |                                                                 | 38,603     |   |      |   | 67,175     |      |  |   | 83,533     |   |  |      | 124,833    |   |  |   | 81,879     |  
|Total shares issued and outstanding                                                      |  |                                                                 | 36,836,853 |   |      |   | 33,895,444 |      |  |   | 30,151,757 |   |  |      | 28,741,194 |   |  |   | 20,754,075 |  
|                                                                                         | 
|                                                                                         |  | Year ended December 31,                                         |           
|                                                                                         |  | 2007                                                            |            |   | 2006 |   |            | 2005 |  |   | 2004       |   |  | 2003 |           
|                                                                                         |  | (amounts in thousands of euro)                                  |           
|Other financial data:                                                                    |  |                                                                 |            |   |      |   |            |      |  |   |            |   |  |      |            |   |  |   |            |  
|Net cash used in operating activities                                                    |  |                                                                 | (66,719    | ) |      |   | (36,622    | )    |  |   | (42,787    | ) |  |      | (37,816    | ) |  |   | (22,974    | )
|Net cash provided by (used in) investing activities                                      |  |                                                                 | 40,847     |   |      |   | 3,706      |      |  |   | 33         |   |  |      | (17,049    | ) |  |   | 18,723     |  
|Net cash provided by financing activities                                                |  |                                                                 | 40,415     |   |      |   | 41,593     |      |  |   | 11,501     |   |  |      | 79,672     |   |  |   | 42         |  
|Depreciation, amortization and impairment of tangible and intangible assets and goodwill |  |                                                                 | 2,722      |   |      |   | 1,857      |      |  |   | 3,895      |   |  |      | 1,981      |   |  |   | 3,827      |  



|(1) | During 2006, the Company adopted SFAS 123R. See accompanying footnotes to the financial statements.
|--- | ---------------------------------------------------------------------------------------------------

|(2) | Does not include restricted cash of 1.4 million, 1.5 million, 1.6 million, 2.3 million and 2.5 million at December 31, 2007, 2006, 2005, 2004,
and 2003, respectively.
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(3) | Does not include obligations under compensation arrangements.
|--- | -------------------------------------------------------------



3



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Exchange Rate Information



The following table shows, for the years and dates indicated, certain information concerning the rate of exchange of euro per U.S. dollar based on the Noon Buying
Rates quoted by the Federal Reserve Bank of New York for euro expressed in U.S. dollars for one euro. No representation is made that the euro or the U.S. dollar amounts referred to herein could have been or could be converted into U.S. dollars or
euro, as the case may be, at any particular rate.



|     |  |                           |  |        |  |                  |  |          
|---- |  | ------------------------- |  | ------ |  | ---------------- |  | ---------
|     |  | U.S. dollars for one euro
|Year |  | High                      |  | Low    |  | PeriodAverage(1) |  | PeriodEnd
|2007 |  | 1.4862                    |  | 1.2904 |  | 1.3797           |  | 1.4603   
|2006 |  | 1.3327                    |  | 1.1860 |  | 1.2661           |  | 1.3197   
|2005 |  | 1.3476                    |  | 1.1667 |  | 1.2401           |  | 1.1842   
|2004 |  | 1.3625                    |  | 1.1801 |  | 1.2478           |  | 1.3538   
|2003 |  | 1.2597                    |  | 1.0361 |  | 1.1411           |  | 1.2597   



|(1) | The average of the Noon Buying Rates on the last business day of each full month during the relevant period.
|--- | ------------------------------------------------------------------------------------------------------------



The high and low exchange rates for the euro for the
periods indicated are set forth below:



|              |  |                          |  |       
|------------- |  | ------------------------ |  | ------
|              |  | U.S. dollars forone euro
|Month         |  | High                     |  | Low   
|December 2007 |  | 1.4759                   |  | 1.4344
|January 2008  |  | 1.4877                   |  | 1.4574
|February 2008 |  | 1.5187                   |  | 1.4495
|March 2008    |  | 1.5805                   |  | 1.5195
|April 2008    |  | 1.6010                   |  | 1.5568
|May 2008      |  | 1.5784                   |  | 1.5370



The Noon Buying Rate for the
euro on June 26, 2008, was quoted by the Federal Reserve Bank of New York at 1.5738 dollars for one euro.



Item 3B. Capitalization and Indebtedness.



Not applicable.



Item 3C. Reasons for the offer and use of proceeds.



Not applicable.



4



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Item 3D. RISK FACTORS



An investment in our shares or American Depository Shares, or ADSs, involves a high degree of risk. You should consider carefully
the specific risk factors described below, together with all of the other information in this annual report. The trading price of our shares and ADSs could decline as a result of any of these risks, and you may lose part or all of your investment.



Risks Related to Our Business



Satraplatin may never receive regulatory approval in the United States or Europe and
may never be successfully commercialized and you may lose all or a substantial part of your investment.



We have expended significant time, money and effort developing satraplatin, our most advanced product candidate. Before we or our partners can market and sell
satraplatin, we will need to obtain necessary approvals from the Food and Drug Administration, or FDA, in the United States, the European Medicines Agency, or EMEA, in Europe and similar regulatory agencies elsewhere.



In July 2007, satraplatin was reviewed by the FDA Oncologic Drugs Advisory Committee,
or ODAC, at a public meeting. At the meeting, the Food and Drug Administration, or FDA, raised certain issues regarding the progression-free survival results of the satraplatin Phase 3 registrational trial in second-line hormone-refractory prostate
cancer, called SPARC, for which it was seeking the advice of ODAC, including whether the FDA should wait for the final overall survival results before taking action on the New Drug Application, or NDA. In its only vote, ODAC recommended that the FDA
should wait for the final overall survival analysis of the SPARC trial before deciding whether the satraplatin NDA was approvable. At the end of July 2007, following the ODAC vote, we withdrew the NDA for satraplatin. In October 2007, we received
disappointing final overall survival results from the SPARC trial. Following these events, we have been exploring different potential registrational pathways for satraplatin based upon additional analyses from the SPARC trial. However, in light of
the disappointing final overall survival results from the SPARC trial and the issues regarding the trial results raised by FDA at the ODAC meeting, achieving marketing approval in the United States will be very challenging, and, even if successful,
will likely require additional post-marketing commitments which are often costly and time consuming Our other ongoing studies with satraplatin are in much earlier stages of development and will continue to require significant funding. Moreover, we
cannot assure you that these studies will be successful or justify further development of satraplatin. We therefore may never successfully commercialize satraplatin in the United States.



In Europe, a Marketing Authorization Application, or MAA, for satraplatin submitted by our partner, Pharmion, now Celgene Corporation
was accepted for filing in mid-2007 and is still under review. The submission was based on the progression-free survival results from the SPARC trial with the understanding that overall survival data would need to be supportive. While the results
from the SPARC trial demonstrated a statistically significant improvement in progression-free-survival, satraplatin did not improve overall survival in the intent-to-treat population in the SPARC trial. In light of the disappointing overall survival
results from the SPARC trial and the issues raised by the ODAC review panel, which issues may also be of concern to the EMEA, approval of the satraplatin MAA will be challenging. If the EMEA does not approve the satraplatin MAA our stock price will
likely decline. A decision on the filing is expected in the second half of 2008.



5



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##### Table of Contents

If we do not receive regulatory approval for satraplatin, or if satraplatin does not achieve market acceptance even
if approved, we will not become profitable in the foreseeable future. If we fail to become or remain profitable, or if we are unable to fund our continuing expenses, we may be unable to continue our development programs, and you could lose all or
part of your investment.



We have a history of losses and expect to
continue to have losses for the next several years. We will never be profitable unless we develop, and obtain regulatory approval and market acceptance of, our product candidates.



We have incurred losses in each year since our inception in 1997 because our research and development and general and administrative
expenses exceeded our revenues. Our net loss for the years ended December 31, 2007, 2006 and 2005 was  69.2 million,  64.0 million and  62.2 million, respectively. As of December 31, 2007, we had an
accumulated deficit of  362.7 million.



To attain profitability, we will need to develop and bring products to market. We have never generated revenue from product sales in the market, and there is no
guarantee that we will be able to do so in the future.



We have expended
significant funds in the development and the preparation for a commercialization of satraplatin. We expect to make substantial additional expenditures and incur substantial losses in the future as we explore various options for satraplatin and in
order to bring our earlier stage kinase inhibitor compounds into the clinic and develop them further. As our product candidates advance, we will continue to need resources for research and development activities, for regulatory approval filings and
for commercialization of any approved drugs.



Our medium to long-term
success will depend largely on our ability to expand our pipeline through M&A activities or in-licensing of promising product candidates. If we are unable to enter into a transaction within the next 12 months, we may be unable to fund our
operations going forward and you could lose all or a significant part of your investment.



We are actively seeking to expand our pipeline through M&A activities or in-licensing of promising product candidates. Our medium to long-term success will largely depend on the success of these activities. We may not be
able to enter into or ultimately execute a transaction due to a variety of factors, including competition from other market participants, especially in the pharmaceutical industry, the volatility of our share price, lack of shareholder approval or
limitations on available cash to fund a transaction. If we are unable to enter into a transaction within the next 12 months or execute a transaction thereafter, our ability to raise funds based on our existing programs will likely be extremely
limited and we may be unable to fund our operations going forward and you could lose all or a significant part of your investment.



We may need substantial additional funding and may be unable to raise capital when needed, which could force us to delay, reduce or eliminate our drug
development activities.



We may need to raise additional capital to
fund our operations and clinical trials and to continue our drug development activities.



We believe our cash, cash equivalents, marketable securities, and short-term investments on hand and interest earned on our investments are sufficient to fund our anticipated operating requirements until approximately the end
of 2010. However, we may need to raise additional funds in the future. Our ability to raise additional funds will largely depend on the strength of our portfolio and the timing and likelihood of developmental milestones, as well as general
financial, economic, market conditions and other factors, many of which are beyond our control. If necessary funds are not



6



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##### Table of Contents

available to us on satisfactory terms, or at all, we may have to reduce expenditures for development and clinical trials, which could delay, reduce or eliminate our
drug development activities.



We are currently engaged in shareholder
litigation. A negative outcome could adversely impact our financial situation.



In July 2007, the Company and certain of its current and former officers were sued in the United States District Court for the Southern District of New York in three separate securities fraud class action lawsuits on behalf of
all persons who purchased the securities of GPC Biotech between December 5, 2005 and July 24, 2007, inclusive. The suits have since been consolidated and a lead plaintiff has been appointed. The consolidated complaint alleges that GPC
Biotech violated U.S. federal securities laws by making misleading public statements relating to the prospects of its most advanced product candidate, satraplatin, and thereby artificially inflating the price of GPC Biotech securities. The
consolidated complaint also names Bernd R. Seizinger, our CEO and three former members of the Companys Management Board, Mirko Scherer, Elmar Maier, and Sebastian Meier-Ewert, as defendants. See also Item 8 Financial
InformationLegal Proceedings.



Even though we believe that
the lawsuits have no merit; we cannot assure you that the outcome of the litigation will be in our favor. We believe our existing D&O insurance will cover lawsuits of this kind; however, if the sum of the litigations cost and a potential
settlement or damages amount exceeds the amount of our coverage, or if the insurers deny coverage, the litigation could adversely impact our financial situation.



In addition to the lawsuits in the United States, we may face lawsuits with similar allegations in Germany in the future, even though,
to our knowledge, none have been filed as of the date of this report.



The primary patents covering satraplatin in the United States will expire in December 2008 and September 2010, and during the first quarter of 2009 in most other countries. If we and the owner of the patents are unable to extend the
protection of these patents beyond such dates, we may be subject to competition from third parties with products with the same active pharmaceutical ingredient as satraplatin.



Even if our product candidates are covered by valid and enforceable patents, the patents will provide protection only for a limited
amount of time. For example, the primary patents covering the active pharmaceutical ingredient and anticancer use of satraplatin will expire in December 2008 and September 2010 in the United States, respectively, and during the first quarter of 2009
in most other countries. Thereafter, we will have no direct means to prevent third parties from making, selling, using or importing satraplatin in the United States, Europe or Japan. Instead, we and Johnson Matthey Plc. as the owner of the primary
patents [and Spectrum Pharmaceuticals, Inc., from whom we sublicense the patent, expect to rely upon the U.S. Drug Price Competition and Patent Term Restoration Act of 1984, commonly known as the Hatch-Waxman Act, and comparable foreign legislation,
to seek additional product exclusivity for satraplatin. If we cannot file a new NDA for satraplatin based on data from the SPARC trial, it would likely prevent us obtaining a timely patent extension of these patents in the US or the EU, and in other
territories including Japan. In addition, even if it is appropriate or possible for us or Johnson Matthey to make an application for patent extension in a timely manner, there can be no assurance that we will ultimately be granted this type of
extension or an analogous extension for satraplatin in any specific country, or at all. See also Item 4 Information about the CompanyIntellectual Property. Should an application for patent extension of a primary patent for
satraplatin be applicable, we plan on supporting the owner of the patent, Johnson Matthey, in their application for such extended protection, if possible, for the fullest term and extent appropriate. The terms of the Hatch-Waxman Act, or similar
foreign statutes, could be amended to our disadvantage.



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If we do not qualify or timely apply for such patent extension for satraplatin, the competition we will face upon expiration of the primary patents would increase
significantly, reducing our potential revenues and harming our ability to achieve profitability.



In addition, we have to rely on Johnson Matthey to make the formal applications for the extension covering satraplatin, should such an application be appropriate.
Whereas they are under an obligation to maximize patent protection for satraplatin and we will provide any support needed for the application, our possibilities to enforce timely and appropriate actions by the owner of the patent are limited.



Under the provisions of applicable law, including the Hatch-Waxman Act,
we and/or the owner of the patent may also have to defend one or more of our patents, if challenged. Although we are currently not involved in any litigation concerning our intellectual property related to satraplatin and we are not currently aware
of any threats or challenges with respect to our product candidates, the risk of a challenge increases as our product candidates progress toward commercialization. Information about the patents covering drug products in the United States is
published by the FDA in a publicly available database, Approved Drug Products with Therapeutic Equivalence Evaluations, also known as the Orange Book. A competitor (usually a generic drug company) seeking to market a proposed competing or generic
version of our drug products in the United States may notify us and/or the owner of the patent that its competing drug product would not infringe one or more patents listed in the Orange Book covering our product, or may challenge the validity or
enforceability of one or more of our listed patents covering our product. Once so notified, the owner of the patent has 45 days in which to file a lawsuit claiming patent infringement based on the competitors assertion about the
characteristics of its proposed product. If a lawsuit is filed within 45 days, the FDA is required to delay, or stay, final approval of the competing product for up to thirty months. If a court determines that the patent would be infringed by the
product proposed in the competitors drug application, the FDA will not approve the application until the patent expires. If, however, the court decides that the patent would not be infringed, is invalid or is unenforceable, the FDA may approve
the competitors drug application when that decision occurs. The FDA may approve the application at the thirty-month date, even if the litigation is ongoing. If litigation is pending and the FDA approves the application at the end of the
thirty-month period, the competitor may launch a competing product. Under the provisions of the Medicare Prescription Drug Improvement and Modernization Act of 2003, we are limited to only a single thirty-month stay per competing or generic drug
application.



We have depended and will continue to depend on our
collaboration with Celgene for a significant portion of our revenues. If this collaboration terminates early or Celgene does not meet all or a significant portion of its obligations, it would materially impact our revenues and harm our business.



Under our co-development and license agreement for satraplatin with
Celgene, we received an upfront payment of $37.1 million, which includes an $18 million reimbursement for past satraplatin clinical development costs and a $19.1 million payment for the funding of certain ongoing clinical development activities.
Furthermore, Celgene has an additional obligation to fund $22.2 million for shared costs incurred in connection with global development activities. We are also entitled to receive up to $105.5 million upon the achievement of regulatory filing and
approval milestones, up to $105 million for achievement of significant annual sales milestones in the Celgene territories and royalties on sales of satraplatin by Celgene in its territories at rates of 26% to 30% on net annual sales up to $500
million, and 34% on net annual sales over $500 million.



These
cost-sharing, milestone and royalty payments from Celgene will represent a significant portion of our revenues for the foreseeable future. If the EMEA does not grant approval of the MAA for satraplatin and/or Celgene is unable to successfully
commercialize satraplatin in its territories or is otherwise unable to meet its contractual obligations, it would have a significant impact on our revenues and financial results.



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Our operating results may fluctuate considerably on a quarterly basis. These fluctuations could have an adverse
effect on the price of our shares and ADSs.



Our results of
operations may fluctuate significantly in the future on a quarterly basis as a result of a number of factors, many of which are beyond our control. Although many companies may encounter this problem, it is particularly relevant to us because of our
relatively small size, the fact that we do not have any marketed products and the dynamics of the biotechnology industry in which we operate. Factors that could cause our results of operations to fluctuate include, among others:



| |  | timing of clinical trial expenses;
| | - | ----------------------------------



| |  | failure to achieve milestones under collaborative arrangements;
| | - | ---------------------------------------------------------------



| |  | regulatory events;
| | - | ------------------



| |  | new product introductions by us or our competitors;
| | - | ---------------------------------------------------



| |  | variations in the demand for products we may introduce;
| | - | -------------------------------------------------------



| |  | litigation involving patents, licenses or other intellectual property; and
| | - | --------------------------------------------------------------------------



| |  | product failures or product liability lawsuits.
| | - | -----------------------------------------------



Any of the foregoing factors could cause us to fail to meet the expectations of securities analysts or investors, which could cause the trading price of our shares
and ADSs to decline.



Currency fluctuations may expose us to increased
costs or revenue decreases.



Our business is affected by fluctuations
in foreign exchange rates between the U.S. dollar and the euro. A significant portion of our revenues and costs are denominated in U.S. dollars. As a result, changes in exchange rates of the U.S dollar to the euro will affect our revenues and costs
and could result in exchange losses. The impact of future exchange rate fluctuations on our results of operations can not be accurately predicted. In addition, the majority of our cash and cash equivalents are denominated in euro.



Our success depends on retaining and recruiting key personnel and, if we fail to do
so, it may be more difficult for us to execute our business strategy.



We depend on key members of our management team and scientific personnel. After our recent restructurings and the related lay-offs, we depend heavily on the personnel we have retained. The implementation of our business strategy and our
future success will depend in large part on our continued ability to retain our existing, and, in the future, potentially attract other highly qualified scientific, technical and management personnel.



The fact that we recently underwent substantial lay-offs and significantly shrunk the
company in size may make it more difficult to retain personnel. We also face competition for personnel from other companies, universities, public and private research institutions and other organizations. The process of hiring suitably qualified
personnel is often lengthy. If our recruitment and retention efforts are unsuccessful in the future, it may be more difficult for us to execute our business strategy.



The members of the Management Board and of the management team identified in Item 6 entitled Directors, Senior Management
and Employees comprise our key employees. Dr. Seizinger, our CEO, has a service agreement for a term of five years. In the United States only Gregory Hamm, our Senior Vice President, Human Resources & Corporate Integration, has
an employment contract; the employment relationships of all other US-based members of our management team are terminable at will.



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If our competitors develop and market products that are more effective, safer or more affordable than ours, or
obtain marketing approval before we do, our commercial opportunities will be more limited.



Competition in the biotechnology and pharmaceutical industries is intense and continues to increase, particularly in the area of cancer treatment. Our competitors include other biotechnology companies, pharmaceutical companies,
as well as academic institutions and other research institutions engaged in the discovery and development of anticancer drugs and therapies. Many of our competitors have significantly greater research and development capabilities, greater experience
in obtaining regulatory approvals, manufacturing and marketing, or greater financial and management resources than we have. Our competitors may succeed in developing products that are more effective, safer or more affordable than the ones we have
under development or that render our product candidates or technologies noncompetitive or obsolete. Moreover, competitors that are able to achieve patent protection obtain regulatory approvals and commence commercial sales of their products before
we do, and competitors that have already done so, may enjoy a significant competitive advantage.



If satraplatin receives marketing approval, it may face significant competition from other drugs that are either marketed or that may be developed for treating
prostate cancer, as well as from other platinum-based compounds and other chemotherapy drugs.



In the prostate cancer market, currently approved drugs include Emcyt® (Pfizer, Inc.), Novantrone® (OSI Pharmaceuticals Inc./Serono S.A.), Quadramet® (Schering AG/EUSA Pharma),
Metastron® (GE Healthcare/Medi-Physics, Inc.) and Taxotere® (Sanofi-Aventis S.A.). Novantrone and Quadramet are injectable pharmaceuticals approved
for use in treating bone pain in cancer patients, and Emcyt is an oral drug used to relieve symptoms of advanced prostate cancer. The most recently approved of these prostate cancer drugs, Taxotere, is an injectable pharmaceutical that is approved
in the United States and Europe, in combination with prednisone (a commonly used synthetic steroid), for the treatment of patients with advanced prostate cancer. Taxotere has been shown to prolong survival of patients with hormone refractory
prostate cancer, or HRPC.



There are currently three marketed platinum-based drugs in the United States and in Europe. These are cisplatin, carboplatin and Eloxatin® (oxaliplatin). All three agents are administered
intravenously and are not approved for the treatment of prostate cancer. In addition to these, there are other platinum-based compounds approved and/or marketed in Asian markets such as lobaplatin (China), nedaplatin (Japan) and eptaplatin (South
Korea). These drugs are not approved, however, for the treatment of prostate cancer and are not approved for any use in the U.S. or Europe. All three of these are also administered intravenously.



Another platinum-based drug, which is not currently on the market, is picoplatin
(Poniard Pharmaceuticals). Picoplatin is administered intravenously. A Phase 3 trial of picoplatin is currently underway in patients with small cell lung cancer whose disease has progressed within six months of completing treatment with first-line
platinum-containing chemotherapy (cisplatin or carboplatin). The primary efficacy endpoint is overall survival. If picoplatin does show efficacy in the clinic against disease that is resistant/refractory to cisplatin or carboplatin and if it is
eventually approved for marketing, it could be a significant competitor to satraplatin. Poniard also is conducting a Phase 2 study evaluating picoplatin in combination with Taxotere and prednisone in the treatment of patients with metastatic HRPC. A
randomized Phase 2 trial to evaluate the efficacy and safety, including neuropathy, of intravenous picoplatin in combination with 5-FU and leucovorin for the first-line treatment of metastatic colorectal cancer is also underway. In addition, a Phase
1 trial is underway evaluating an oral formulation of picoplatin compared to the IV formulation in solid tumors.



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Even if our product candidates are approved for marketing, they may not be competitive with established drugs and
therapies or may not be able to supplant established products and therapies in the disease settings that we target, thereby reducing the commercial value of our products.



We depend on intellectual property licensed from third parties, and termination of any of these licenses could result in the loss of significant
rights, which would harm our business.



We hold licenses granted by
Spectrum Pharmaceuticals, Inc. for satraplatin and by other parties related to certain of our other product candidates. We also hold licenses to third party patents important for our research technologies. Any termination of these licenses could
result in the loss of significant rights and could harm our ability to commercialize our drug candidates. Our ownership of patents relating to some or all of our products will not reduce our reliance on these and other third party patents.



Our agreement with Spectrum Pharmaceuticals is a sublicense under a
license agreement between Spectrum Pharmaceuticals and Johnson Matthey. We must therefore rely on Spectrum Pharmaceuticals to enforce its rights and Johnson Mattheys obligations under their license agreement. If Spectrum Pharmaceuticals were
to become insolvent or go into receivership, we would have limited access to assets related to satraplatin and limited ability to enforce directly any of Spectrum Pharmaceuticals rights or Johnson Mattheys obligations under such
agreement. As a result, our development and commercialization of satraplatin could be significantly delayed or prevented.



When we license intellectual property from third parties, those parties generally retain most or all of the obligations to maintain, extend as well as the rights to
assert, prosecute and defend that intellectual property. We generally have no rights to require our licensors to apply for new patents, except to the extent that we actually assist in the creation or development of patentable intellectual property.
With respect to intellectual property that we license, we are generally also subject to all of the same risks with respect to its protection as we are for intellectual property that we own, which are described below.



We rely on third parties to supply the active pharmaceutical ingredients in our
product candidates. If they do not supply materials of satisfactory quality, in a timely manner, in sufficient quantities or at an acceptable cost, clinical development and commercialization of our product candidates could be delayed.



We depend and will depend on supply, quality and other agreements
for compounds that are essential for the development and commercialization of our product candidates, including satraplatin. Our supply of the active ingredient for satraplatin and other product candidates may become limited, be interrupted or
become restricted in certain geographic regions, and our suppliers may not perform their contractual obligations, for reasons including a shortage of raw materials or adverse regulatory actions. In this event, if we have not yet completed
negotiations with alternate suppliers, we may not be able to obtain materials of acceptable quality from other manufacturers, or at prices, on terms or in quantities acceptable to us or in a timeframe consistent with project plans. Any inability to
obtain alternate suppliers, including an inability to obtain approval of an alternate supplier from the FDA and other regulatory agencies, would delay or prevent the clinical development and commercialization of satraplatin and our other product
candidates.



In 2005, we entered into an exclusive commercial supply
agreement with Johnson Matthey for additional supplies of the active pharmaceutical ingredient (API) for satraplatin for future clinical trials, as well as for commercial amounts of satraplatin. Johnson Matthey has been our sole supplier of
satraplatin to date and has also been selected as our back-up supplier, using different facilities to minimize disruption risks. If supply from Johnson Matthey were to be interrupted or our relationship



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with Johnson Matthey were to terminate, we could face delays with respect to our ongoing clinical trials and potential future sales of satraplatin. We estimate that
replacing Johnson Matthey with an alternative supplier could take up to one year.



We rely on third parties to manufacture the finished form of our product candidates. If they do not manufacture our product candidates in finished form of satisfactory quality, in a timely manner, in sufficient quantities or at an
acceptable cost, clinical development and commercialization of our product candidates could be delayed.



We do not currently own or operate manufacturing, distribution, warehousing or finishing facilities and rely and expect to continue to rely on third parties for the
production of clinical and commercial quantities of the finished form of our product candidates. To date, our product candidates have been manufactured at the scale required for preclinical studies or clinical trials. If satraplatin or any of our
other product candidates is approved by the FDA or other regulatory agencies for commercial sale, we will need to have it manufactured in commercial quantities. We have selected a commercial vendor for satraplatin finished product and have
manufactured the supplies necessary for a commercial launch of satraplatin. Our current and anticipated future dependence upon others for the manufacture of the finished form of our product candidates may adversely affect our ability to develop and
commercialize any product candidates on a timely and competitive basis. We may also not be able to maintain or renew our existing manufacturing arrangements on acceptable terms, if at all.



We rely on third parties to conduct clinical trials and assist with preclinical
activities. If they do not perform as contractually required or expected, we may not be able to obtain regulatory approval for or commercialize our product candidates.



We do not have the ability to independently conduct clinical trials for our product candidates, and we rely on third parties, such as contract
research organizations, medical institutions, clinical investigators and contract laboratories to conduct our clinical trials for satraplatin and our other product candidates. In the event that our contract research organizations were to terminate
their agreements with us and, as a result, we needed to transfer responsibilities to a new contract research organization, we believe we could engage one or more new contract research organizations with sufficient qualifications and international
capabilities. Any of the foregoing events could, however, cause significant delays, disruptions and cost increases in our trials.



In addition, we rely on third parties to assist us with our preclinical development of product candidates. Our preclinical development activities or clinical trials
may be extended, delayed, suspended or terminated, if:



| |  | these third parties do not successfully carry out their contractual duties or regulatory obligations or meet expected deadlines;
| | - | --------------------------------------------------------------------------------------------------------------------------------



| |  | these third parties need to be replaced; or
| | - | -------------------------------------------



| |  | the quality or accuracy of the data they obtain is compromised due to the failure to adhere to our clinical protocols or regulatory requirements or for other reasons.
| | - | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------



If any of these events occur, we may not be able to obtain
regulatory approval for, or successfully commercialize our product candidates.



We depend in part on the continued availability of outside scientific collaborators, including researchers at clinical research organizations and universities, in areas relevant to our research and product development. The competition for
these relationships is intense, and we cannot assure you that we will be able to maintain such relationships on acceptable terms, if at all. In addition, these outside relationships may be terminated by the collaborator at any time. Our scientific
collaborators are



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not employees of GPC Biotech. As a result, we have limited control, if any, over their activities and can expect that only limited amounts of their time will be
dedicated to GPC Biotech activities. In addition, we may not control any intellectual property resulting from their activities.



Risks Related to Our Industry



Our product candidates must undergo rigorous clinical testing, the results of which are uncertain and could substantially delay or prevent us from bringing these
products to market.



Before we can obtain regulatory approval for a
product candidate, we must undertake extensive clinical testing in humans to demonstrate the products safety and effectiveness. These clinical trials are expensive, time-consuming and often take years to complete. According to pharmaceutical
industry statistics published in 2001 by the Pharmaceutical Research and Manufacturers of America, an average drug candidate receiving approval for marketing as a prescription drug required 6.5 years of clinical testing prior to submission of a
request to the FDA for marketing approval.



In connection with clinical
trials, we face risks that:



| |  | the product candidate may not be efficacious;
| | - | ---------------------------------------------



| |  | the product candidate may cause harmful side effects or patients may die;
| | - | -------------------------------------------------------------------------



| |  | the results may not confirm the results of earlier trials; or
| | - | -------------------------------------------------------------



| |  | the results may not meet the level of statistical significance or clinical benefit required by the FDA or other regulatory agencies.
| | - | ------------------------------------------------------------------------------------------------------------------------------------



Any of these events could cause a trial to fail and may significantly delay or prevent
us from obtaining regulatory approval for a product candidate.



Difficulties in enrolling patients in our clinical trials may increase costs and negatively affect the timing and outcome of our trials.



Completion of clinical trials depends, among other things, on our ability to enroll a sufficient number of patients, which is a function of many factors, including:



| |  | the nature of the clinical protocol;
| | - | ------------------------------------



| |  | the therapeutic endpoints chosen for evaluation;
| | - | ------------------------------------------------



| |  | the eligibility criteria for the trial that is related to the protocol;
| | - | -----------------------------------------------------------------------



| |  | the size of the patient population required for analysis of the trials therapeutic endpoints;
| | - | ----------------------------------------------------------------------------------------------



| |  | our ability to recruit clinical trial investigators with the appropriate competencies and experience;
| | - | -----------------------------------------------------------------------------------------------------



| |  | competition for patients by clinical trial programs for other treatments;
| | - | -------------------------------------------------------------------------



| |  | the proportion of patients leaving the study before reaching an endpoint; and
| | - | -----------------------------------------------------------------------------



| |  | the availability of adequate insurance.
| | - | ---------------------------------------



We may experience difficulties in enrolling patients in our clinical trials, which could increase the costs or affect the timing or outcome of these trials.



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We are subject to significant regulatory approval requirements, which could delay, prevent or limit our ability
to market our product candidates.



Our research and development
activities, preclinical studies, clinical trials and the anticipated manufacturing and marketing of our product candidates are subject to extensive regulation by the FDA and other regulatory agencies in the United States and by comparable
authorities in Europe and elsewhere. We require the approval of the relevant regulatory authorities before we may commence commercial sales of our product candidates in a given market. The regulatory approval process is expensive and time-consuming,
and the timing of receipt of regulatory approval is difficult to predict.



Our product candidates could require a significantly longer time to gain regulatory approval than expected, or may never gain approval. A delay or denial of regulatory approval could delay our ability to generate product revenues and to
achieve profitability.



Changes in the regulatory approval policy during
the development period of any of our product candidates, changes in, or the enactment of, additional regulations or statutes, or changes in regulatory review practices for a submitted product application may cause a delay in obtaining approval or
result in the rejection of an application for regulatory approval.



Regulatory approval, if obtained, may be made subject to limitations on the indicated uses for which we may market a product. These limitations could adversely affect our potential product revenues and our ability to achieve profitability.
Regulatory approval may also require costly post-marketing follow-up studies. In addition, the labeling, packaging, adverse event reporting, storage, advertising, promotion and record-keeping related to the product will be subject to extensive
ongoing regulatory requirements. Furthermore, for any marketed product, its manufacturer and its manufacturing facilities will be subject to continual review and periodic inspections by the FDA and other regulatory authorities. Failure to comply
with applicable regulatory requirements may, among other things, result in fines, suspensions of regulatory approvals, product recalls, product seizures, operating restrictions and criminal prosecution.



We have no control over our key manufacturers and suppliers compliance
with manufacturing regulations and their failure to comply could result in an interruption in the supply of our product candidates.



The manufacturing process of pharmaceutical products is highly regulated. Our present or future manufacturers and suppliers may not be able to comply with FDA
mandated current Good Manufacturing Practices, or cGMP, other FDA regulatory requirements or similar regulatory requirements outside the United States. Any failure by our third-party manufacturers or suppliers to comply with applicable regulations
could result in sanctions being imposed on them (including fines, injunctions and civil penalties), the failure of regulatory authorities to grant marketing approval of our product candidates, delays, suspension or withdrawal of approvals, license
revocation, seizures or recalls of product candidates or products, operating restrictions and criminal prosecution. Any of these events would likely cause an interruption in the supply of our product candidate and cost increases.



We are dependent on patents and proprietary technology, both our own and those
licensed from others. If we or our licensors fail to adequately protect this intellectual property or if we do not have exclusivity for the marketing of our products, our ability to commercialize products could suffer.



Our success depends in part on our ability, and the ability of our licensors, to obtain
patent protection for technologies, products and processes, to preserve trade secrets, to defend and enforce rights against infringement and to operate without infringing the proprietary rights of third parties, in the



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United States, Europe and elsewhere. The validity and breadth of claims in medical or pharmaceutical technology and biotechnology or life science patents involve
complex legal and factual questions and, therefore, may be highly uncertain. For example, the value of our intellectual property rights depends on whether:



| |  | the inventors of our patents, or those we co-own or license were the first to make the inventions or the first to file patent applications covering the intellectual property important for our
business;
| | - | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  | the applicants of our patents obtained the appropriate rights, including that of ownership, from the inventors of such patents;
| | - | -------------------------------------------------------------------------------------------------------------------------------



| |  | we will develop, co-develop, acquire or license additional technologies or product candidates that are patentable;
| | - | ------------------------------------------------------------------------------------------------------------------



| |  | the scope of any patent protection we, the co-owners of our intellectual property rights or our licensors receive will exclude competitors or provide us with competitive advantages;
| | - | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  | any of the patents that have been or may be issued to us, the co-owners of our intellectual property rights or our licensors will provide protection for commercially viable products, or be
held valid if subsequently challenged;
| | - | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  | we or our licensors effectively prosecute, maintain, defend, extend and enforce the patents and patent applications we have licensed;
| | - | -------------------------------------------------------------------------------------------------------------------------------------



| |  | patent authorities will grant patents to our competitors or others that restrict our business based on applications they have filed or may file;
| | - | ------------------------------------------------------------------------------------------------------------------------------------------------



| |  | we will be able to detect, or, if detected, defend in an effective manner against infringement of any patent we, the co-owners of our intellectual property rights or our licensors receive;
| | - | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  | others claim rights in, or ownership of, the patents and other proprietary rights that we hold or license;
| | - | ----------------------------------------------------------------------------------------------------------



| |  | any patent that we, the co-owners of our intellectual property rights or our licensors receive will be eligible under, and benefit from, any laws or regulations governing patent term
extension;
| | - | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  | the patents of others have an adverse effect on our business; or
| | - | ----------------------------------------------------------------



| |  | others have developed or will develop similar technologies, product candidates, products or processes, duplicate any of those, or design around any patents that have been or may be issued to
us, the co-owners of our intellectual property rights or our licensors, particularly in relation to satraplatin or our other product candidates.
| | - | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



We try to protect our proprietary position by generally filing U.S. and foreign patent applications related to those of our proprietary developments, inventions
and improvements that are important to our business, including those related to the development of our product candidates. Our ability to obtain patents is, however, highly uncertain because, to date, some legal principles remain unresolved and
there has not been a consistent policy regarding the breadth or interpretation of claims allowed in patents in the United States and elsewhere. Moreover, the specific content of patents and patent applications that are necessary to support and
interpret patent claims is highly uncertain due to the complex nature of the relevant legal, scientific and factual issues. The policies and legal-precedent governing biotechnology and pharmaceutical patents outside the United States, especially in
Germany, are even more uncertain. Changes in either patent laws or in interpretations of patent laws in the United States and other countries may diminish the value of our intellectual property or narrow the scope of our patent protection. For
example, we are aware that certain changes to the rules governing



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patent prosecution in the United States have been proposed by the United States Patent and Trademark Office, or USPTO. These proposed rules, if implemented, could
significantly limit the scope of patent protection we are able to achieve in the United States for a given invention, and could increase our liability for litigation and challenges related to the validity or enforceability of any patents granted
under such rules. It is still uncertain if these rules or rules similar to them will be enacted in the United States, as these proposed rules have been challenged in court by certain third parties. The USPTO has appealed the decision made by the
court of first instance.



Patents, if issued, may be challenged,
invalidated or circumvented. United States patents and patent applications may also be subject to interference proceedings, and U.S. patents may be subject to reexamination proceedings. Foreign patents may be subject to opposition or comparable
proceedings. Moreover, the Federal Food, Drug, and Cosmetic Act and FDA regulations and policies provide incentives to manufacturers to challenge patent validity or create modified, non-infringing versions of a drug in order to facilitate the
approval of abbreviated new drug applications for generic substitutes. Such proceedings could result in either loss of the patent or denial of the patent application or loss or reduction in the scope of one or more of the claims of the patent or
patent application. In addition, such interference, reexamination and opposition proceedings may be costly and time-consuming, and even if we were to prevail, would distract management. Although we are not currently facing any threats of these types
of legal actions with respect to our product candidates, the risk of these legal actions increases as our product candidates progress toward commercialization and should they ultimately be approved and commercialized.



Any patents or patent applications that we own, co-own or license from others may not
provide any protection against competitors. Our pending patent applications, those we may file in the future, or those we have licensed or may license from third parties, may not result in patents being issued. If issued, the patents may not provide
us with proprietary protection or competitive advantages against competitors with similar technology, products or processes. Furthermore, others may independently develop similar technologies, products or processes or duplicate any of those that we
have developed.



We depend on third parties, such as patent-annuity
payment companies, to pay the annuity, renewal and other fees required to maintain our patents and patent applications. Non-payment or delay in the payment of these fees is likely to result in irrevocable loss of patents or patent rights important
to our business.



We, the co-owners of our intellectual property
rights or our licensors may face difficulties in protecting intellectual property in countries other than the United States, which may diminish the value of our intellectual property in those countries.



The laws of some foreign jurisdictions do not protect intellectual property rights to
the same extent as in the United States and Europe, and many companies have encountered significant difficulties in protecting and defending such rights in foreign jurisdictions. If we, the co-owners of our intellectual property rights or licensors
encounter such difficulties in protecting, or are otherwise precluded from effectively protecting, in foreign jurisdictions the intellectual property rights important for our business, the value of these rights may be diminished and we may face
additional competition from others in these jurisdictions.



Many
countries, including certain countries in Europe, have compulsory licensing laws under which a patent owner may be compelled to grant licenses to third parties (if, for example, the patent owner has failed to work the invention in that
country, or the third party has patented improvements). In addition, many countries limit the enforceability of patents against government agencies or government contractors. In these countries, the patent owner may have limited remedies, which
could materially diminish the value of the patent.



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Some of our and our collaborators research and development employees and/or consultants work in Germany or other
European countries and are subject to German employment law or comparable rules in other European jurisdictions. Ideas, developments, discoveries and inventions made by such employees and consultants are subject to the provisions of the German Act
on Employees Inventions (Gesetz über Arbeitnehmererfindungen) or similar European legislation, which regulates the ownership of, and compensation for, inventions made by employees. For such inventions, we face the risk that
disputes can occur between employer and employee, ex-employee, or employers of our consultants pertaining to alleged non-adherence to the provisions of this act. Even if we, the co-owners of our intellectual property rights or licensors prevailed in
any such dispute, such action could result in substantial costs and be a distraction to management. If we fail in such dispute, in addition to paying substantial money damages, we may lose valuable intellectual property rights.



Claims that we infringe a third partys intellectual property may give rise to
burdensome litigation, result in potential liability for damages or stop our development and commercialization efforts.



The pharmaceutical, biotechnology and other life sciences industries are characterized by the existence of a large number of patents and frequent litigation based
upon allegations of patent infringement. The owners or licensees of these and other patents may file one or more injunctive or infringement actions against us or our collaborators or licensees. Patent litigation can involve complex factual and legal
questions, and its outcome is uncertain. Any claim relating to infringement of patents that is successfully asserted against us may result in us paying substantial money damages. Even if we were to prevail, any litigation could be costly and
time-consuming and would divert the attention of our management and key personnel from our business operations. Furthermore, as a result of a patent infringement suit brought against us or our collaborators or licensees, we or our partners or
licensees may be forced to stop or delay developing, manufacturing or selling products that are claimed to infringe a third partys intellectual property unless that party grants us or our collaborators or licensees rights to use its
intellectual property. In these cases, we or our collaborators or licensees may be required to obtain licenses to patents or proprietary rights of others in order to continue to commercialize our products. However, we or our collaborators or
licensees may not be able to obtain any licenses required under any patents or proprietary rights of third parties on acceptable terms, or at all. Even if our collaborators, licensees or we were able to obtain rights to the third partys
intellectual property, these rights may be non-exclusive, thereby giving our competitors access to the same intellectual property. Ultimately, we or our collaborators or licensees may be unable to commercialize some of our products or may have to
discontinue development or use of a technology or product candidate or cease some of our or their business operations as a result of patent infringement claims, which could severely harm our business.



United States and foreign patents have been issued to third parties in the same fields
as some of our technologies and product candidates and in fields that relate to the development, manufacture and use of our product candidates. For example, there are numerous patent filings claiming various genetic sequences, such as protein coding
sequences and regulatory sequences, and those that claim other research tools that may have been used in our research programs and technologies. We have not attempted to obtain licenses to any of these patents. If we decide to obtain licenses to
these patents, we cannot guarantee that we would be able to obtain such licenses on commercially reasonable terms, or at all. Should we not obtain one or more appropriate licenses and infringement claims be brought against us, we may be unable to
convince a court that the allegedly infringed patent was invalid or otherwise unenforceable against our product candidates, research programs or technologies, and we may be prevented from practicing or marketing our product candidates, research
programs or technologies, or may incur costs related to any retroactive infringement, in countries in which the patent is in force.



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While our product candidates are in clinical trials, and prior to commercialization, we believe our activities in
the U.S. fall within the scope of the exemptions from patent infringement provided by 35 U.S.C. Section 271(e)(1) in the United States, which covers activities related to developing information for submission to the FDA. As our product
candidates progress toward commercialization, the possibility of an infringement claim against us increases. Analogous provisions have been implemented in a number of European countries following recent EU directives related to pharmaceutical
development, but such provisions have been implemented differently in the different states and the scope and effectiveness of such provisions are not yet certain. Analogous provisions may not exist or may not exempt from patent infringement those
clinical trials we conduct in other countries.



Our or our
partners ability to successfully launch and market satraplatin as a drug product may depend on obtaining, using, protecting and defending a proprietary brand name. If we or our partners are unable to use or defend a proprietary brand name, we
and our partners may loose certain marketing advantages and/or delay market introduction of any approved drug product.



If we were to market satraplatin in the United States under a proprietary brand name, we are required to use a name that is acceptable to the FDA, to the EMEA and
also to regulatory authorities in other territories where we may wish to market satraplatin under such name. We therefore may still be unable to receive such acceptance for our desired brand name from one or more regulatory authorities, including
the FDA. This can lead to a delay in launch or first commercial sale of satraplatin, or the need to use a different brand name, or use of the non-proprietary name, in one or more territories or markets. Furthermore, although we conduct trademark
availability and clearance analysis for our potential brand names in a number of key jurisdictions, we may be ultimately unable to register our desired brand name as a trademark or third parties may believe our brand name infringes their own
trademark rights. Such situations or actions by third parties could lead to a delay, change or an injunction preventing the sale of satraplatin under our desired brand name in one or more territories or markets, including the United States. We
believe that these risks are higher in the European market, since the European Union usually requires a single brand name for the entire European Union. With 25 separate Member States and approximately 20 different languages comprising the EU, the
challenges to obtaining an acceptable brand name and trademark for all such states are substantial, and we or our marketing partner, Celgene, may have to delay or make changes to our marketing plans in the European market, or other markets, because
of such risks.



Our competitive position also depends on trade secrets
and other forms of non-patented intellectual property protection. If we are unable to protect our trade secrets, other companies may be able to compete more effectively against us, and our business could suffer.



We also rely on trade secrets, know-how and technology, which are not protected by
patents, to maintain our competitive position. We try to protect this information by entering into confidentiality agreements with parties that have access to it, such as our collaborators, licensees, employees and consultants. Any of these parties
may breach these agreements and disclose our confidential information, or our competitors might learn of the information in some other way. If any trade secret, know-how or other technology not protected by a patent were to be disclosed to or
independently developed by a competitor, our ability to generate revenues from our product candidates could be severely damaged.



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We may be required to pay substantial money damages resulting from claims that we or our employees have
wrongfully used or disclosed alleged trade secrets of their former employers or other third parties.



Many of our employees were previously employed at other biotechnology or pharmaceutical companies, including our competitors or potential competitors, or at
universities. We and our employees have received information from third parties that such third parties may believe was received or should be treated under an obligation of confidentiality. Although no claims against us are currently pending, we may
in the future be subject to claims that these employees or we have inadvertently or otherwise used or disclosed trade secrets or other proprietary information of their former employers or other third parties. Litigation may be necessary to defend
against these claims. Even if we are successful in defending against these claims, litigation could result in substantial costs and be a distraction to management. If we fail in defending such claims, in addition to paying substantial money damages,
we may lose valuable intellectual property rights or personnel. A loss of key research personnel or their work product could delay or prevent our ability to commercialize one or more of our product candidates.



We are subject to significant environmental, health and safety regulation,
compliance with which can be expensive.



We are subject to a variety
of health, safety and environmental laws and regulations in the United States, Germany and other countries. These laws and regulations govern, among other things, waste water discharge, air emissions and waste management. We have incurred, and will
continue to incur, capital and operating expenditures and other costs in the ordinary course of our business in complying with these laws and regulations. Because we produce small amounts of experimental compounds and operate laboratory facilities,
some risk of environmental liability is inherent in our business. Additionally, material costs of environmental compliance may arise in the future, increasing the overall costs of regulatory compliance.



We may become exposed to costly and damaging product liability claims and may not be
able to maintain sufficient product liability insurance to cover claims against us. Even in the absence of product liability lawsuits, unforeseen adverse side effects could harm sales of our products.



We face the risk of substantial liability for damages in the event a patient
experiences adverse side effects during clinical trials or after any drugs we may develop are marketed. If any of our products were to cause adverse side effects, substantial losses in excess of our insurance coverage could result, which could
negatively impact our financial condition, results of operations and cash flows. Our products are intended to be used to treat cancer cases, in which the patient and physician may conclude that the therapeutic benefits of the drug outweigh the
potential risk of adverse side effects. Nevertheless, patients who suffer complications may attribute these complications to the drug and, as a consequence, bring product liability actions against us.



Although the clinical trial process is designed to identify and assess potential side
effects, it is always possible that a drug, even after approval, may exhibit unforeseen adverse side effects. Such side effects could affect the safety profile of the product. Even if these side effects are not so serious as to warrant withdrawing
the product from use, they could reduce the products competitive advantage, especially if alternative products offer comparable therapeutic benefits with less severe potential side effects.



We maintain limited product liability insurance for our product candidates when used in
clinical trials. In several countries that have legally mandated amounts of coverage, we have purchased insurance to meet these requirements, which varies widely from 1.0 million per study in Hungary to



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50.0 million in Germany. For other countries, such as the United States,
where there is no such legal mandate, our insurance coverage is limited to $20 million per occurrence and in the aggregate. We expect to obtain more extensive product liability insurance for any products that we may eventually commercialize when it
is economical and appropriate to do so, given the level of premiums and the risk and magnitude of potential liability. We may not be able to obtain insurance on acceptable terms or at all or the amount of insurance we have may not be adequate to
cover potential claims or losses. Uninsured losses would adversely affect our profitability.



We may not be able to conduct, or contract others to conduct, animal testing in the future, which could harm our research and development activities.



Certain laws and regulations relating to drug development require us to test our product candidates on animals before initiating
clinical trials involving humans. Animal testing activities have been the subject of controversy and adverse publicity. Animal rights groups and other organizations and individuals have attempted to stop animal testing activities by pressing for
legislation and regulation in these areas and by disrupting these activities through protests and other means. To the extent the activities of these groups are successful, our research and development activities may be interrupted or delayed.



Risks Related to an Investment in Our Company



The price of our shares and ADSs is highly volatile and could decline significantly.



The market price of our ordinary shares and our ADSs historically
has been, and we expect will continue to be, subject to significant fluctuations over short periods of time. These fluctuations may be due to factors specific to us, to changes in analysts recommendations and earnings estimates, or to factors
affecting the biopharmaceutical industry or the securities markets in general. For example, during the period from January 1, 2007 to December 31, 2007, the price per share of our ordinary shares on XETRA ranged from 24.93 to 2.62. During the period from January 1, 2007 to December 31,
2007, the price per ADS on the Nasdaq Global Market, or Nasdaq, ranged from $32.85 to $3.60. We may experience a material decline in the market price of our shares or ADSs, regardless of our operating performance.



Price declines in our shares could result from a variety of factors, including many
outside our control. These factors include:



| |  | EMEA, FDA or other regulatory actions, especially in connection with the MAA filing for satraplatin;
| | - | ----------------------------------------------------------------------------------------------------



| |  | adverse results or delays in our clinical trial programs failure of any of our product candidates, if approved, to achieve commercial success;
| | - | ----------------------------------------------------------------------------------------------------------------------------------------------



| |  | announcements of the introduction of new products by us or our competitors;
| | - | ---------------------------------------------------------------------------



| |  | market conditions in the pharmaceutical and biotechnology sectors;
| | - | ------------------------------------------------------------------



| |  | adverse developments in existing or the commencement of new litigation;
| | - | -----------------------------------------------------------------------



| |  | litigation or public concern about the safety of our potential products;
| | - | ------------------------------------------------------------------------



| |  | changes in recommendations or earnings estimates by securities analysts;
| | - | ------------------------------------------------------------------------



| |  | actual and anticipated fluctuations in our quarterly operating results;
| | - | -----------------------------------------------------------------------



| |  | deviations in our operating results from the estimates of securities analysts;
| | - | ------------------------------------------------------------------------------



| |  | rumors relating to us or our competitors;
| | - | -----------------------------------------



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| |  | departures of key personnel;
| | - | ----------------------------



| |  | changes in third party reimbursement policies; and
| | - | --------------------------------------------------



| |  | developments concerning current or future strategic alliances or acquisitions.
| | - | ------------------------------------------------------------------------------



We have never paid dividends on our shares, and we do not anticipate paying dividends in the foreseeable future.



We have never paid dividends on our shares. Under German corporate law, we currently
have no ability to pay dividends because of our past losses. We do not expect to have any annual net income for the foreseeable future. We currently plan to retain our future annual net income, if any, to fund our product development activities and
internal growth. As a result, capital appreciation, if any, of our shares will be your sole potential source of gain for the foreseeable future.



The price of our ADSs and the U.S. dollar value of any dividends will be affected by fluctuations in the U.S. dollar/euro exchange rate.



Our ADSs trade in U.S. dollars. Fluctuations in the exchange rate between the euro and
the U.S. dollar may affect the market price of the ADSs. This could adversely affect the price at which the ADSs trade on the U.S. securities markets. Additionally, any dividend we might pay in the future would be denominated in euro. A decline in
the value of the euro against the U.S. dollar would reduce the dollar equivalent of any such dividend.



Future sales of our shares in the public market could adversely affect the price of our shares and ADSs.



The market price of our shares and ADSs could drop due to sales of a large number of
our shares in the market or the perception that such sales could occur. These sales could also make it more difficult for us to sell equity securities in the future at a time and at a price that we deem appropriate.



As of December 31, 2007, members of our Supervisory Board and Management Board
together held approximately 1.7% of our outstanding shares. Subject to company policies and applicable law, we and members of our Supervisory Board and our Management Board are free to issue, offer, sell or otherwise dispose of shares.



Rights as a shareholder in a German corporation may differ from rights customary
for a shareholder in a U.S. corporation.



We are organized as a stock
corporation (Aktiengesellschaft) under the laws of Germany. Our shareholders should be aware that the rights of shareholders under German law differ in important respects from those of shareholders in a U.S. corporation. These differences are
described in greater detail in Item 4 of this Annual Report under German Corporate Law.



In addition, as a non-U.S. corporation, we are not subject to some of the provisions of U.S. securities laws that apply to U.S. issuers. We are not subject to the
proxy rules promulgated under Section 14 of the U.S. Securities Exchange Act of 1934, or Exchange Act. Additionally, short-swing profit and recovery provisions under Section 16 of the Exchange Act do not apply to us or the members of our
Management Board and Supervisory Board. Furthermore, as a foreign private issuer, we are not required to file quarterly reports on Form 10-Q or current reports on Form 8-K with the U.S. Securities and Exchange Commission. In accordance with German
law and the rules and regulations promulgated by the Frankfurt Stock Exchange, GPC Biotechs historical practice, however, has been to



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publish its three-, six- and nine-month interim financial information. We expect to continue this practice, and to furnish this information to the U.S. Securities and
Exchange Commission in the United States on Form 6-K.



We may become a
passive foreign investment company, which could result in adverse U.S. tax consequences to U.S. investors.



Depending on various factors, we could be classified, for United States income tax purposes, as a passive foreign investment company, or PFIC. This
characterization could result in adverse U.S. federal income consequences for any U.S. holder of our shares or ADSs. We could be classified as a PFIC for U.S. federal income tax purposes in any taxable year in which, after taking into account the
income and assets of our subsidiary, either:



| |  | at least 75% of our gross income is passive income, or
| | - | ------------------------------------------------------



| |  | at least 50% of the average value of our assets is attributable to assets that produce or are held to produce passive income.
| | - | -----------------------------------------------------------------------------------------------------------------------------



We currently believe that we will not be treated as a PFIC for the taxable year ended
December 31, 2007. We note, however, that the decline in the trading prices of our shares in the last year, to the extent suggestive of a lower fair market value for our assets, may increase the likelihood that we will be treated as a PFIC for
the taxable year ending December 31, 2008, or for subsequent years.



The determination of whether we are a PFIC is made on an annual basis and will depend on factors such as the composition of our income and assets from time to time as well as our share price, and there are uncertainties in the application
of the relevant rules. In addition, the U.S. Internal Revenue Service, or IRS, is not bound by our determinations regarding PFIC status, which are based on various assumptions and factual determinations, and may successfully assert that we are or
have been a PFIC for any particular year. Therefore, it is possible that we could be classified as a PFIC for any particular year.



If we are treated as a PFIC for any taxable year, U.S. investors in our shares or ADSs may be able to make an election to mark-to-market our shares or
ADSs each taxable year and recognize ordinary income pursuant to such election based upon increases in the value of our shares or ADSs.



Absent an election described above, were we classified as a PFIC, a U.S. holder of our shares or ADSs would be subject to adverse tax consequences, including:



| |  | U.S. federal income tax at ordinary income tax rates in respect of gain derived from a disposition of our shares or ADSs, as well as some distributions by us;
| | - | --------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  | interest charges on taxes allocable to prior periods; and
| | - | ---------------------------------------------------------



| |  | no increase in the tax basis for our shares or ADSs to fair market value upon the death of an individual shareholder.
| | - | ---------------------------------------------------------------------------------------------------------------------



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Item 4. Information on the Company



INTRODUCTION



History and Development



The legal and commercial name of our company is GPC Biotech AG. We were originally formed as a limited liability company (Gesellschaft mit beschränkter
HaftungorGmbH) under German law in January 1997. In February 1998, we transformed into a stock corporation (Aktiengesellschaft or AG) under German law and changed our name to GPC Aktiengesellschaft Genome Pharmaceuticals
Corporation. On March 3, 2000, we changed our name to GPC Biotech AG.



Our principal executive offices are located at Fraunhoferstrasse 20, D-82152 Planegg (Martinsried)/Munich, Germany and our telephone number is 011 49 89 8565 2600. Our corporate website is located at www.gpc-biotech.com. Our authorized
representative in the United States is Brent Hatzis-Schoch, Senior Vice President & General Counsel, and our agent for service in the United States is our U.S. subsidiary, GPC Biotech Inc., located at 101 College Road East, Princeton,
NJ 08540. Our ordinary shares are traded on the Frankfurt Stock Exchange under the symbol GPC and our ADSs are traded on Nasdaq under the symbol GPCB. We are a biotechnology company with a main focus on developing
anticancer drugs.



Capital Expenditures



See Item 5 Operating and Financial Review and Prospects for a
description of our capital expenditures.



Business Overview



GPC Biotech is a biopharmaceutical company focused on anticancer drugs. Our lead
product candidate is satraplatin, an oral platinum compound. We have various anti-cancer programs in research and development that leverage our expertise in kinase inhibitors. GPC Biotech AG is headquartered in Martinsried/Munich (Germany) and has a
wholly owned U.S. subsidiary in Princeton, New Jersey.



The year 2007 was
a challenging year for GPC Biotech, with a major setback involving the results of the Phase 3 trial for satraplatin discussed below. In late 2007, however, we implemented a revised strategic plan and are currently seeking to rebuild the Company by
moving what we believe are our most promising development programs forward and pursuing opportunities to combine with or acquire other companies that could complement our own programs and expand our asset portfolio.



Satraplatin



In February 2007, we completed an NDA submission for satraplatin based on the results of a Phase 3 trial, called the SPARC trial, in
second-line hormone refractory prostate cancer. The results showed a statistically significant improvement in progression-free survival. Based on these results, we requested accelerated approval in the U.S. for satraplatin. That submission was
accepted by the FDA and granted priority review status. In July 2007, an FDA advisory panel recommended that the agency await the final overall survival results from the trial before determining if the satraplatin NDA submission was approvable.
Based on this recommendation, we withdrew the satraplatin NDA. In late October 2007, we announced that satraplatin did not demonstrate an improvement in overall survival in the total intent-to-treat patient population in the SPARC trial.



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In Europe, our partner Pharmion GmbH (now Celgene Corporation), submitted a MAA for satraplatin in mid-2007. That
submission was accepted by the EMEA and a decision on the filing is expected in the second half of 2008. See also: Item 3D Risk FactorsSatraplatin may never receive regulatory approval in the United States or Europe and may never be
successfully commercialized and you may lose all or a substantial part of your investment.



In June 2007, we announced a partnership for satraplatin in Japan with Yakult Honsha Co. Ltd. (Yakult). Under the terms of the agreement, we granted Yakult an
exclusive commercialization rights to satraplatin for Japan and Yakult took the lead in developing the drug in that country.



Following the disappointing overall survival results from the SPARC trial, we conducted extensive analyses of the data to gain a better understanding of the overall
survival results. We also evaluated all ongoing and planned trials with satraplatin and decided to stop some trials and continue others. In addition, we have been exploring potential alternative registrational paths for satraplatin with our partners
and cooperative oncology groups who might be interested in leading studies.



Other development programs



We have two kinase
inhibitor compounds in pre-clinical development. Pre-clinical work for the most advanced of these compounds, RGB-286638, has been completed, and we expect to begin Phase 1 clinical testing in the second half of 2008. Testing in cancer cells has
shown that RGB-286638 leads to cell cycle inhibition and induces apoptosis (programmed cell death), key elements in stopping the spread of cancer cells. Data in animal tumor models show that use of RGB-286638 results in tumor regression and
increases survival time.



A second drug candidate, RGB-344064, is
undergoing the necessary pre-clinical testing to move this compound into the clinic. RGB-344064, has been shown to selectively inhibit all key Cdks.



In February 2008, we announced that we had decided to discontinue internal development of our monoclonal antibody, 1D09C3, which was in Phase 1 clinical testing for
relapsed/refractory B-cell lymphomas.



Corporate



In May 2007, we announced our decision to consolidate our drug
discovery efforts to one location. This consolidation involved closing our facility in Waltham, Massachusetts.



In August 2007, following the withdrawal of the NDA for satraplatin, we implemented a corporate restructuring that included staff reductions in the U.S. We
implemented another restructuring in November 2007 after we learned of the overall survival results from the SPARC trial that involved significant staff reductions in both the U.S. and Germany, as well as a re-evaluation of our programs.



Effective January 1, 2008, GPC Biotech appointed Torsten Hombeck, Ph.D. to
Chief Financial Officer. Dr. Hombeck joined GPC Biotech in 1999 and was previously Vice President, Finance. He replaced Mirko Scherer, Ph.D., who left the Company at the end of 2007.



In February 2008, we announced an additional corporate restructuring to sharpen our
focus on oncology clinical development efforts and to further reduce costs. The restructuring was mainly focused on our early-stage research activities in Munich. The combined restructuring activities in 2007 and February 2008 resulted in a
reduction of approximately 71% of the total workforce consisting of approximately 336 employees.



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As part of the February 2008 restructuring, we announced that, by mutual consent, Elmar Maier, Ph.D., Chief
Operating Officer/Martinsried and Senior Vice President, Business Development, and Sebastian Meier-Ewert, Ph.D., Senior Vice President and Chief Scientific Officer had retired from their positions on the Management Board of the Company to allow for
an appropriate resizing of the Management Board, given the reduced size of the Company. Both Dr. Maier and Dr. Meier-Ewert remain dedicated to the Company as advisors.



We are actively exploring potential mergers and acquisitions (M&A), as well as possible in-licensing opportunities in part to fill
our oncology development pipeline.



In past years, we have funded our
operations primarily through the issuance of equity securities, payments received under our collaboration and license agreements with other pharmaceutical companies, interest earned on investments and other sources of funding. Management expects to
continue to fund the Companys operations over the next several years primarily through our existing cash resources and marketable securities, sales of equity and debt securities, potential future payments from its co-development and licensing
partners as well as interest earned on investments.



At December 31,
2007, we held  49.7 million in cash and cash equivalents and 
14.1 million in short-term investments and marketable securities. In addition, we also had  1.4 million in restricted cash at that date. We expect these
cash reserves to be sufficient to fund currently planned business operations until approximately the end of 2010.



Our Strategy



We are focused on oncology because this is an area in which, despite progress in understanding cancer and the resulting development of new therapies, there is still a lack of effective treatments. Also, due to the relatively
short timeframe and low number of patients needed for oncology clinical trials, the costs of clinical development of anticancer drugs are significantly lower than those for many other diseases. Our management and drug development teams have
extensive experience in the field of oncology. We believe that the oncology markets rapid growth and substantial unmet medical need, combined with our focused expertise, position us to compete effectively in oncology drug development.



To decrease our risk profile and secure the long-term viability of our
company, we seek to build a strong portfolio of oncology drugs. We seek to do this by:



| |  | Advancing our most promising internal product candidates.We are focusing our resources and internal efforts on developing those product candidates that we feel
have the greatest likelihood of ultimately making it onto the market. These candidates currently include satraplatin and two kinase inhibitors in pre-clinical development.
| | - | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  | Expanding our development pipeline by bringing in external compounds.    To achieve the goal of filling the development pipeline, we are primarily focusing on
M&A activities, in particular involving firms that have clinical-stage programs in oncology. We believe that we bring important assets and attractive qualities to M&A opportunities. These include an internationally experienced management
team; a solid cash position; a transatlantic presence that includes stock market listings in the U.S. and Germany; and development-stage drug programs.
| | - | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



We have a drug development team that has extensive experience in designing and conducting successful clinical trial programs. With our
internal expertise, we seek to design clinical (registrational) programs for our product candidates that will minimize the time to market and maximize the likelihood of approval.



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Our Product Pipeline



Cancer is the second leading cause of death in the United States after cardiovascular disease. The American Cancer Society estimates that in 2008 there will be over
1,437,000 new cases of cancer diagnosed and over 565,000 deaths attributable to cancer in the United States. According to GLOBOCAN 2002, in the year 2002, there were a total of over 2.8 million new cases of cancer and 1.7 million deaths
attributable to cancer throughout Europe.



Many different approaches are
used in treating cancer, including surgery, radiation therapy, drugs or a combination of these approaches. Drugs used to treat cancer include chemotherapeutics, antibodies, hormones and immune-based therapies. According to IntrinsiQ, over
1 million cancer patients were treated with anticancer agents in 2007 in the United States. According to IMS estimates, the worldwide sales of anticancer drugs totaled over $24 billion in 2004 and are forecast to reach $55 billion in 2009.



We currently have one product candidate in clinical development and two
in pre-clinical development as follows:



|                                                       |  |                                                                                                                                                             
|------------------------------------------------------ |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------
|Product Candidate                                      |  | Development Status                                                                                                                                          
|                                                       | 
|Satraplatin                                            |  | Marketing authorization application under review in Europe for treatment of hormone-refractory prostate cancer patients whose prior chemotherapy has failed;
|                                                       | 
|                                                       |  | Phase 1 and 2 trials underway and planned in several cancer types and combinations                                                                          
|                                                       | 
|RGB-286638 broad-spectrum kinase inhibitor             |  | Pre-clinical testing; expected to enter Phase 1 clinical testing in the second half of 2008                                                                 
|                                                       | 
|RGB-344064 selective cyclin-dependent kinase inhibitor |  | Pre-clinical testing                                                                                                                                        



Satraplatin



Our lead product candidate is satraplatin, a member of the
platinum family of drugs. Platinum-based drugs represent one of the mainstays of modern chemotherapy and are used to treat a wide variety of cancers. We withdrew our NDA with the FDA for satraplatin in July 2007; an MAA with the EMEA is still
pending. We licensed the exclusive commercial rights to satraplatin, including the right to sublicense, in the field of treating cancer in humans, from Spectrum Pharmaceuticals at the end of the third quarter of 2002. In December 2005, we entered
into a co-development and license agreement for satraplatin with Pharmion, now Celgene, for Europe, the Middle East, including Turkey, Australia and New Zealand.



In June 2007, we entered into a partnership for satraplatin in Japan with Yakult Honsha Co. Ltd. Under the terms of the agreement, we
granted Yakult an exclusive commercialization rights to satraplatin for Japan and Yakult took the lead in developing the drug in that country. Yakults pharmaceutical business specializes in cancer and cancer-related ailments. They are the
inventor of irinotecan hydrochloride, which is a global standard drug for colorectal cancer, and have a track record of successfully commercializing another platinum-based drug, oxaliplatin, in Japan. While Yakult remains committed to satraplatin
and supportive of GPC Biotech, the setback in the United States has caused a major delay in seeking approval for satraplatin in Japan. We continue to work together with Yakult to determine the next steps forward for satraplatin in that country.



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Market Opportunity



Three platinum-based drugs are currently marketed in the United States and Europe: carboplatin, cisplatin and Eloxatin. These
platinum-based drugs, which are administered intravenously, are used to treat more than 34 different cancers; in many cases regimens containing a platinum-based drug represent the current standard of care. Satraplatin is administered orally in the
form of capsules. Satraplatin has been studied in a variety of adult cancers in clinical trials conducted by us and by others. Despite the setback in advancing satraplatin onto the market in 2007, we continue to believe that satraplatin holds the
potential to be an active anticancer agent, and we are seeking to develop this product candidate for the treatment of various cancers. In randomized clinical trials, satraplatin has shown anticancer activity in HRPC and is believed to be the only
platinum-based compound for which such clinical data have been generated.



History and Prior Clinical Trials of Satraplatin



Satraplatin was invented and synthesized by scientists at Johnson Matthey as part of a collaboration with Bristol-Myers Squibb to find new platinum-based chemotherapy drugs. Unlike any of the marketed platinum-based drugs, satraplatin
showed anticancer activity when administered orally. A number of clinical trials involving satraplatin were conducted by Bristol-Myers Squibb, and the drug candidate showed activity in several cancer types, including HRPC, ovarian and lung cancer.



An important clinical trial initiated during this period was a
randomized Phase 3 trial comparing outcomes in a group of HRPC patients who received satraplatin plus prednisone to outcomes in another group that received prednisone alone. Bristol-Myers Squibb initiated this clinical trial in 1998 with the
intention of enrolling 380 patients. The trial was conducted by the European Organization for the Research and Treatment of Cancer (EORTC). In 1999, Bristol-Myers Squibb terminated its satraplatin program. At that time the EORTC had entered 50
patients into the trial. The EORTC investigators continued to treat these 50 patients until either their cancer progressed or they died. The EORTC investigators reported the results at the 2003 Annual Meeting of the American Society of Clinical
Oncology (ASCO) and the results were published in the peer-reviewed medical journal Oncology in February 2005. The major finding from the trial was a significant prolongation of time during which patients lived without their cancer
progressing (progression-free survival) in the group treated with satraplatin plus prednisone.



The SPARC Trial



Chemotherapy is
increasingly being used in the treatment of HRPC, and this has created a greater need for additional effective therapeutic options for HRPC patients, especially for second-line chemotherapy treatments because a cure is not expected in HRPC with
currently approved first-line chemotherapy treatments, including Taxotere regimens. Thus, with the data from the above study conducted by the EORTC in HRPC and the need for new treatments, we decided to initiate a registrational Phase 3 trial with
satraplatin in second-line hormone refractory prostate cancer.



In
September 2003, we initiated the SPARC trial, a multinational, multicenter, randomized, double-blind Phase 3 registrational trial to test satraplatin plus prednisone versus a placebo plus prednisone in patients with HRPC whose prior chemotherapy had
failed. Randomized means that patients are randomly assigned to receive the drug candidate or a placebo. Double-blind means that neither the physician nor the patient knows whether the patient has received the drug candidate
or a placebo. Progressed on first-line chemotherapy means that a patient with HRPC has shown further advancement of their cancer while being treated with a regimen that includes a chemotherapy drug. The SPARC trial was designed to
determine the efficacy and evaluate the safety of satraplatin plus prednisone in this patient population. A total of 950 patients were enrolled in the trial at approximately 170 clinical centers in sixteen countries on four continents.



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During the first half of 2007, data from the SPARC trial were presented at major medical conferences in the U.S.
and Europe. The data presented showed a statistically significant improvement in progression-free survival, time to pain progression, pain response and PSA (prostate specific antigen) response.



Regulatory Update



Based on the above data, we moved forward to complete the submission of an NDA to the
FDA in February 2007. We requested accelerated approval for satraplatin for the treatment of HRPC patients whose prior chemotherapy had failed. The submission was based on the progression-free survival data from the SPARC study, the primary endpoint
for accelerated approval in the U.S. This submission was accepted for filing by the agency and granted priority review status in April 2007. Priority review designation is intended for those products that address significant unmet medical needs and
sets the target date for FDA action at six months from the date of submission, which was mid-August 2007 for the satraplatin NDA.



In July 2007, satraplatin was reviewed by the FDA Oncologic Drugs Advisory Committee (ODAC) at a public meeting. Advisory committees provide the FDA with
independent advice from outside experts on issues related to human drugs and other regulated areas. The ODAC recommended that the FDA should wait for the final overall survival analysis of the SPARC trial before deciding whether the satraplatin
application was approvable. Based on the ODAC recommendation, we decided to withdraw the NDA for satraplatin and to submit a new NDA that focused on the overall survival results when those data became available.



In late October 2007, we received the results of the final overall survival analysis
and announced that the SPARC trial did not achieve the overall survival endpoint, with patients receiving satraplatin doing no better than the control group (p=0.80, stratified log rank analysis). The median was 61.3 weeks for the satraplatin arm
compared to 61.4 weeks for the control group and the hazard ratio was 0.97 (95% CI: 0.83, 1.13).



Following the announcement of these topline overall survival results, we conducted pre-specified analyses on
the overall survival of subsets of patients to gain additional insight into the data and to try to better understand why the trial had the results it did. An exploratory analysis adjusting for the three pre-specified prognostic factors which
exhibited statistically significant imbalances between the two treatment arms showed a positive trend in those patients who had progressed after receiving Taxotere. This is important because Taxotere is now the standard of care for first-line
chemotherapy in HRPC patients in many countries, including the U.S. These results were presented at the ASCO Annual Meeting in June 2008. The significance of these results for the satraplatin program has not yet been determined. Additional analyses
of the SPARC trial overall survival data are ongoing.



A Marketing
Authorization Application for satraplatin in Europe, submitted by our partner, Pharmion, now Celgene, was accepted for filing in 2007 and is still under review. The submission was based on the progression-free survival results from the SPARC trial
with the original understanding that overall survival data would need to be supportive. While the results from the SPARC trial demonstrated a statistically significant improvement in progression-free-survival, satraplatin did not improve overall
survival in the intent-to-treat population in the SPARC trial. In light of the disappointing overall survival results from the SPARC trial and the issues raised by the ODAC review panel, which issues may also be of concern to the EMEA, approval of
the satraplatin MAA will be very challenging. A decision on the filing is expected in the second half of 2008.



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Revised Development Plan



Following the receipt of the overall survival results from the SPARC trial, we carefully evaluated all of the ongoing and planned studies with
satraplatin. Decisions were made to continue some trials and stop others. We are also planning the initiation of new studies. Decisions made and plans under evaluation include:



| | 1) | Two Phase 1 trials evaluating satraplatin in combination with Taxotere are being completed. Following analysis of safety results
from these combination studies, we may consider pathways for further development in prostate cancer. Data from these studies were presented or published at the 2008 ASCO Annual Meeting.
| | -- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | 2) | Two Phase 1 trials in combination with Xeloda, an oral chemotherapy that is used to treat a variety of cancers, including
metastatic breast and colorectal cancers, are being completed. A regimen composed of all-oral drug treatments, if safe and effective, offers the potential to be a convenient and flexible treatment for patients. Data from one of these studies were
presented at the 2008 ASCO Annual Meeting.
| | -- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | 3) | The ongoing Phase 1 trial evaluating satraplatin in combination with radiation therapy in non-small cell lung cancer is being completed. Data from this study were presented at the 2008 ASCO
Annual Meeting.
| | -- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | 4) | Several clinical trials have been stopped. This includes a randomized Phase 2 trial evaluating satraplatin in combination with Tarceva in elderly patients with non-small cell lung cancer. The
trial data to date did not show sufficient efficacy signals to warrant continuing the Tarceva combination study.
| | -- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | 5) | We also stopped enrollment in the U.S. Satraplatin Expanded Rapid Access protocol (SPERA) in late 2007. Expanded Access Programs are intended to give patients access to investigational drugs
to treat serious or life-threatening diseases or conditions for which there are no adequate therapies available. Patients in the trial have hormone-refractory prostate cancer and have been treated with at least one other chemotherapy regimen prior
to entering SPERA.
| | -- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | 6) | We are currently considering several registrational paths for satraplatin and are discussing potential plans with our partners, as well as with cooperative oncology groups, which are clinical
cancer research organizations. Any decision to pursue a particular path will be driven by the likelihood of registrational success, the commercial potential for a given indication, and necessary investments and timelines of such
trials.
| | -- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



Manufacturing



We do not currently own or operate manufacturing facilities for the production of
clinical or commercial quantities of satraplatin. Johnson Matthey manufactured the material that we are using in our clinical trials of satraplatin. We also have a supply agreement with Johnson Matthey for additional supplies of the active
pharmaceutical ingredient, or API, for commercial amounts of satraplatin as well as for our future clinical trials. Our arrangements with Johnson Matthey include that they will also serve as a back-up supplier, using a different facility. Johnson
Matthey has been a major manufacturer of platinum-based pharmaceuticals for many years.



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Kinase inhibitors



During 2007, we advanced two pre-clinical kinase inhibitors, RGB-286638 and RGB-344064. Protein kinases play an important role in
signaling between and within cells. There are more than 500 human protein kinases, many of which have been implicated in tumor growth and spread. One reason a cell can become cancerous is an uncontrolled growth signal that is sent to the nucleus on
a pathway of kinases. By inhibiting selected kinases in such pathways, the uncontrolled division of tumor cells can be slowed or even halted. Several kinase inhibitors have been approved for marketing as anticancer drugs in recent years, and
research and development in this area holds a great potential for future treatment options for cancer patients.



For several years, we have been studying kinase inhibitors that act as cell cycle inhibitors. The cell cycle is a vital process in the body, controlling cell
division and ensuring accurate duplication of genetic material. In cancer cells, this process fails to function normally, resulting in uncontrolled cell proliferation. Studies on a wide range of human cancers have shown that mutations in genes that
regulate the cell cycle are found in almost all cases. Thus, drugs that inhibit the cell cycle could be useful in treating a large number of different cancers.



Cyclin-dependent kinases (Cdks) are proteins that are involved in the regulation of the cell cycle. At least four different Cdks control various key events
during this process, and inhibiting these Cdks may be useful in stopping the spread of tumor cells.



RGB-286638 broad-spectrum kinase inhibitor.    RGB-286638 has been shown in vitro to lead to the inhibition of the cell
cycle, targeting all relevant Cdks, and to the induction of apoptosis (programmed cell death). RGB-286638 also inhibits other major kinases that are important in controlling the proliferation of cancer cells. In a range of pre-clinical models in
both solid and liquid tumors, this small molecule resulted in tumor regression and increased survival. Pre-clinical work has been completed in the areas of safety, pharmacology, toxicology and chemistry, manufacturing and controls. A starting dose
and intravenous schedule for the compound for Phase 1 clinical testing has been determined, and the program is expected to enter the clinic during the second half of 2008. Clinical trials are planned in both solid and hematological tumors in Europe
and the U.S.



RGB-344064 selective Cdk
inhibitor.A second drug candidate, RGB-344064, has been shown to selectively inhibit all key Cdks. In vivo testing has demonstrated that this compound can be dosed at levels that should be suitable for clinical
testing, and the remaining toxicology and other pre-clinical testing needed to advance this compound into the clinic is currently underway.



1D09C3 monoclonal antibody.In February 2008, we announced that we had decided to discontinue internal development of our
1D09C3 monoclonal antibody that was in Phase 1 clinical testing for relapsed/refractory B-cell lymphomas. Initial clinical testing with 1D09C3 did not raise any unexpected or unacceptable safety concerns and the maximum tolerated dose was not
reached. However, independent data published on other human IgG4 antibodies in the second half of 2007 raised general concerns about the family of IgG4 antibodies, to which 1D09C3 belongs. These data indicate that an IgG4 antibody may swap one half
of its Y-shaped structure with the half of a different antibody, resulting in a new molecule whose properties are unknown. We conducted testing and determined that 1D09C3 has this swapping characteristic. While these results are not
definitive, we decided not to put further internal resources into developing 1D09C3. However, we will seek a partner for the intellectual property relating to this program.



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Commercialization



In December 2005, we signed a major co-development and license agreement with Pharmion, now Celgene, for satraplatin. Under this collaboration, Celgene gained
exclusive commercialization rights to satraplatin for Europe, the Middle East, Turkey, Australia and New Zealand. Additionally, this partner is assisting us in funding satraplatins development.



In June 2007, we entered into a partnership for satraplatin in Japan with Yakult Honsha
Co. Ltd. Under the terms of the agreement, Yakult gained exclusive commercialization rights to satraplatin for Japan and took the lead in developing the drug in that country. While Yakult remains committed to satraplatin and supportive of GPC
Biotech, the setback in the United States has caused a major delay in seeking approval for satraplatin in Japan. We continue to work together with Yakult to determine the next steps forward for satraplatin in that country.



We have retained the rights to satraplatin in the U.S. and some other markets outside
of Europe and Japan.



We have retained all commercial rights to all of
our other development programs.



Intellectual Property



We actively seek, when appropriate, intellectual property protection for our
developments, product candidates and proprietary information that are important to the commercial development of our business. We do this through filing for, prosecuting, maintaining or licensing relevant United States, European and/or other foreign
patents and or trademarks. In addition, we rely upon trade secrets and contractual arrangements to protect proprietary information that may be important to the development of our business.



We aim to file for, prosecute, maintain or license those patents, patent applications
and trademarks that we believe are relevant to the strategic needs of our business, and hence the exact number and scope of issued patents, pending patent applications and/or trademarks to which we have rights at any given time may increase,
decrease or otherwise change in the future.



For example, under our
exclusive sub-license from Spectrum Pharmaceuticals, Inc., we have access to intellectual property, including the primary patents to satraplatin, owned by Johnson Matthey that is important to our ability to develop and commercialize our product
candidate, satraplatin.



Under our Collaborative Research, Development
and Marketing Agreement with Bristol-Myers Squibb, we have certain co-exclusive rights to intellectual property owned by certain third parties relevant to our ability to develop and commercialize certain of our pre-clinical product candidates, in
particular our kinase inhibitors.



We also have certain exclusive or
co-exclusive rights to other patents and patent applications relevant to the technologies used in our business, other research & development programs, certain of our pre-clinical product candidates and other areas.



These rights have been licensed or sub-licensed from various academic institutions and
pharmaceutical and biopharmaceutical companies.



Generally, patents
expire 20 years after their earliest nonprovisional filing date. However, U.S. patents issuing from patent applications filed before June 8, 1995 will expire after the longer of 17 years after issuance or 20 years after the earliest
nonprovisional filing date. U.S. patents may also



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be extended in limited circumstances by a period representing delay by the United States Patent and Trademark Office, or USPTO, and hence the exact expiry date of
currently pending U.S. applications cannot be predicted. The protection of certain patents to the extent they cover approved pharmaceutical products may be extended by up to five years under provisions of the Hatch-Waxman Act in the United States
and analogous provisions in other countries. See Government RegulationRegulation in the United StatesDrug Price Competition and Patent Term Restoration Act of 1984. Patents and patent applications also will expire early
if appropriate renewal or annuity fees are not paid in a timely manner to the appropriate patent office or if prosecution actions or responses are not filed with the relevant patent office according to applicable regulations.



Satraplatin.    Satraplatin is protected by two issued U.S. patents, a patent issued under the European Patent Convention, or EPC, and a number of patents issued in other national jurisdictions including
other EU countries, Japan, Canada and Australia. These patents are owned by Johnson Matthey, and we hold an exclusive sublicense, with the right to sublicense, under these patents through our Co-development and License Agreement with Spectrum
Pharmaceuticals, Inc. in the field of treating cancer in humans. In most jurisdictions, these patents cover the composition of matter and anticancer uses of various platinum-based compounds, including satraplatin. The two U.S. patents expire in
December 2008 and September 2010, respectively, and during the first quarter of 2009 in most other countries. Under provisions such as the Hatch-Waxman Act in the United States and analogous regulations in Europe, there are opportunities to extend
the patent life of a patent to cover any approved drug product in a given jurisdiction. These regulations provide for the possibility of a patent term extension of up to five years to only one of the U.S. patents related to satraplatin and a
Supplementary Protection Certificate in European countries to extend the patent term in countries of the European Union and certain other European countries, and any appropriate national equivalents in the European Union, by up to five years. See
Item 3D Risk FactorsThe primary patents covering satraplatin in the United States will expire in December 2008 and September 2010, and during the first quarter of 2009 in most other countries. If we and the owner of the patents are
unable to extend the protection of these patents beyond such dates, we may be subject to competition from third parties with products with the same active pharmaceutical ingredient as satraplatin. Separately, we own certain published patent
applications, currently in prosecution in the US and elsewhere, that relate to certain possible therapeutic uses of satraplatin. Recently, we announced the granting of a European Patent (EP 1 720 540 B1) related to the treatment of a cancer or tumor
resistant or refractory to a taxane, including docetaxel (Taxotere) and paclitaxel (Taxol). With an active filing for satraplatin under review in Europe, we believe this patent would be relevant, should satraplatin be approved in Europe for HRPC
patients whose prior docetaxel therapy has failed. The basic term of this patent extends up to 2025.



Kinase Inhibitors.    Our two kinase inhibitors in advanced pre-clinical development are structurally distinct compounds. These
two compounds are covered by separate families of patent applications that, if issued and maintained, would be expected to expire in 2024 in most major markets for RGB-286638, and later for RGB-344064. As a result of an earlier collaboration with
Bristol-Myers Squibb (BMS), we license other issued patents and patent applications that are important to these kinase inhibitors.



We intend to continue using our experience to pursue and seek patent protection for new developments with respect to compositions, methods of use and other aspects
of such developments that may enhance our position with respect to our product candidates.



Patents, if issued, may be challenged, invalidated or circumvented. Thus, any patent that we own, co-own or license from third parties may not provide adequate protection against competitors. Our pending patent applications,
those we may file in the future, or those we may license from third parties may not result in issued patents. Also, patents may not provide us with adequate proprietary



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protection or advantages against competitors with similar or competing technologies. We are aware that numerous patent applications owned by third parties have been
filed and are currently pending and expect that others may be filed in the future in fields similar to our technologies or product candidates. For example, there are numerous patent filings claiming various genetic sequences, such as protein coding
sequences and regulatory sequences, and those that claim other research tools that may have been used in our research programs and technologies. We have not attempted to obtain licenses to any of these patents. Due to these factors and the inherent
uncertainty in conducting patent searches, we may violate third-party patent rights that we have not yet identified, or fully or correctly investigated. As a result of potential conflicts with the proprietary rights of others, we or our
collaborators or licensees may in the future have to prove that we or our collaborators or licensees are not infringing the patent rights of others or be required to obtain one or more licenses to third-party patents. We do not know whether such a
license would be available on commercially reasonable terms, or at all. If we or our collaborators or licensees are unable to secure such licenses, we or our collaborators or licensees may be required by a court to cease further development, use or
commercialization of one or more of our technologies or product candidates, including satraplatin.



The technologies used in our business comprise a complicated set of individual components or techniques, some of which are protected by intellectual property owned
by third parties. We have entered into certain licenses to intellectual property covering particular enabling components or techniques that comprise parts of our technologies. Under the terms of certain of these licenses we will owe milestone and
royalty payments to the licensors for the development and commercialization of the licensed intellectual property or products derived therefrom. Under such licenses, we are also obliged to grant back rights to improvements and certain other
intellectual property to the licensor. In the future, we may be required to take additional licenses to other intellectual property that is necessary to some of our technologies, product candidates or products at additional cost to us.



Much of our technology and many of our processes depend upon the knowledge,
experience and skills of our scientific and technical personnel. To protect rights to our trade secrets, proprietary know-how and technology, we require our employees, contractors, consultants, advisors and collaborators, as well as potential
collaborators, to enter into confidentiality agreements or other obligations of confidentiality that prohibit the disclosure of confidential information and require disclosure of all ideas, developments, discoveries and inventions related to our
proprietary know-how, trade secrets or technology. Under these agreements, our employees and most of our consultants are generally obligated to assign to us all rights to such ideas, developments, discoveries and inventions, and to reasonably assist
us in any further prosecution of patent applications filed to cover such inventions. Many of our and our collaborators research and development employees and/or consultants work in Germany or other European countries and are subject to the
provisions of the German Act on Employees Inventions (Gesetz über ArbeitnehmererfindungenArbNErfG) (or similar regulation in other European countries), which regulates the ownership of, and compensation for, inventions made
by employees and under which their employer, which is not in all cases GPC Biotech, has first rights to inventions made by them. It is possible, however, that these parties may breach those agreements, and we may not have adequate remedies for any
breach. It is also possible that our trade secrets or unpatentable know-how will otherwise become known or be independently developed by competitors, for which there most likely will be no remedy available to us. Additionally, we or our co-owners or
licensors may not have complied, or may not in the future comply, with the provisions of the ArbNErfG,or similar regulation, and may become subject to disputes relating to alleged non-adherence to the provisions of the ArbNErfG or
such similar regulation.



Some of our advisors and consultants are
currently employed by universities or other commercial entities. Most of these individuals are parties to agreements pursuant to which some of the work product created by these individuals belongs to their respective employers. While we and these
individuals try to maintain records that make it clear that the work these individuals do for us is not



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subject to their agreements with their employer, it is always possible that an employer such as a university will assert an ownership claim to the work of one or more
of these individuals.



Trademarks



We own rights in the following trademarks: GPC Biotech, the GPC Biotech design, the
globe design, and a number of other trademarks related to our current and past technologies or business areas. All other trademarks or trade names referred to in this annual report are the property of their respective owners. We also have rights to
a number of trademarks and trademark applications in a variety of jurisdictions, including the United States and the European Union, that represent potential brand names for our future commercial drug-products including satraplatin. If we wish to
market satraplatin in the United States under a proprietary brand name, we are required to use a name that is acceptable to the FDA, to the EMEA and also to regulatory authorities in other territories where we may wish to market satraplatin under
such name. Celgene, our commercial partner for satraplatin in Europe submitted to the EMEA three potential brand names for which they have received clearance. We have submitted two such names to the FDA for clearance and have received unfavorable
feedback from the FDA for one such name, but have not received comment on the other name. We therefore may still be unable to receive such acceptance for our desired brand name from one or more regulatory authorities, including the FDA. This can
lead to a delay in launch or first commercial sale of satraplatin, or the need to use a different brand name, or use of the generic name, in one or more territories or markets. Furthermore, although we conduct trademark availability and clearance
analysis for our potential brand names in a number of key jurisdictions, we may be ultimately unable to register our desired brand name as a trademark or third parties may believe our brand name infringes their own trademark rights. Such situations
or actions by third parties could lead to a delay, change or an injunction preventing the sale of satraplatin under our desired brand name in one or more territories or markets, including the United States. We believe that these risks are higher in
the European market, since the European Union usually requires a single brand name for the entire European Union. With 25 separate Member States and approximately 20 different languages comprising the EU, the challenges to obtaining an
acceptable brand name and trademark for all such states are substantial, and we or our marketing partner, Celgene, may have to delay or make changes to our marketing plans in the European market, or other markets, because of such risks.



Competition



We operate in the highly competitive segment of the pharmaceutical market composed of pharmaceutical and biotechnology companies that research,
develop and commercialize products designed to treat cancer. Many of our competitors have significantly greater financial, manufacturing, marketing and product development resources than we do. Large pharmaceutical companies in particular have
extensive experience in clinical testing, obtaining regulatory approval for and commercializing drugs. These companies also have significantly greater research capabilities than we do. In addition, many universities and private and public research
institutes are active in cancer research, some in direct competition with us. We also must compete with these organizations to recruit personnel.



Satraplatin.    If satraplatin is approved and commercialized, it will face significant competition. Competition for satraplatin
may include other drugs either marketed or being developed for the cancer indications for which we seek to develop satraplatin, as well as other platinum-based compounds and other drugs for other cancers.



There are currently three marketed platinum-based drugs in the United States and in
Europe. These are cisplatin, carboplatin and Eloxatin. All three agents are administered intravenously and are not indicated for the treatment of prostate cancer. In addition to these, there are other platinum-based



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compounds approved and/or marketed in Asian markets such as lobaplatin (China), nedaplatin (Japan) and eptaplatin (South Korea). These drugs are not approved, however,
for any use in the U.S. or Europe. All three of these are also administered intravenously.



Another platinum-based drug, which is not currently on the market, is picoplatin. Picoplatin is administered intravenously. A Phase 3 trial of picoplatin is currently underway in patients with small cell lung cancer whose
disease has progressed within six months of completing treatment with first-line platinum-containing chemotherapy (cisplatin or carboplatin). The primary efficacy endpoint is overall survival. If picoplatin does show efficacy in the clinic against
disease that is resistant/refractory to cisplatin or carboplatin and if it is eventually approved for marketing, it could be a significant competitor to satraplatin. Poniard also is conducting a Phase 2 study evaluating picoplatin in combination
with Taxotere and prednisone in the treatment of patients with metastatic HRPC. A randomized Phase 2 trial to evaluate the efficacy and safety, including neuropathy, of intravenous picoplatin in combination with 5-FU and leucovorin for the
first-line treatment of metastatic colorectal cancer is also underway. In addition, a Phase 1 trial is underway evaluating an oral formulation of picoplatin compared to the IV formulation in solid tumors.



In the prostate cancer market, currently approved drugs include Emcyt (Pfizer, Inc.),
Novantrone (OSI Pharmaceuticals, Inc./Serono S.A.), Quadramet (Schering AG/EUSA Pharma), Metastron (GE Healthcare/Medi-Physics, Inc.) and Taxotere (Sanofi-Aventis S.A.). Novantrone and Quadramet are injectable pharmaceuticals approved for use in
treating bone pain in cancer patients, and Emcyt is an oral drug used to relieve symptoms of advanced prostate cancer. The most recently approved of these prostate cancer drugs, Taxotere, is an injectable pharmaceutical that is approved in the
United States and Europe, in combination with prednisone, for the treatment of patients with advanced prostate cancer. Taxotere has been shown to prolong survival of patients with HRPC.



Government Regulation



Regulation by governmental authorities in the United States and other countries is a significant factor in the development, manufacture and marketing of
pharmaceutical products and in ongoing research and development activities. All of our products will require regulatory approval by governmental agencies prior to commercialization. In particular, pharmaceuticals are subject to rigorous preclinical
testing and clinical trials and other pre-marketing approval requirements by the FDA and regulatory authorities in other countries.



Regulation in the United States



In the United States, drugs are subject to regulation by the FDA. The Federal Food, Drug, and Cosmetic Act and other federal and state statutes and regulations
govern, among other things, the research, development, testing, safety, effectiveness, manufacture, quality control, storage, record keeping, labeling, promotion, marketing and distribution of pharmaceutical products. The failure to comply with the
applicable regulatory requirements may subject a company to a variety of administrative or judicially imposed sanctions and/or the inability to obtain or maintain required approvals or to market approved drug products.



In addition, the lengthy process of seeking required approvals and the continuing need
for compliance with applicable statutes and regulations require the expenditure of substantial resources. Regulatory approval, when and if obtained for any of our products, may be limited in scope, which may significantly limit the indicated uses
for which our products may be marketed. Furthermore, approved drugs and manufacturers are subject to ongoing review. The emergence of previously unknown problems, including new safety signals related to marketed products, may result in restrictions
on the products manufacture, sale or use or in their withdrawal from the market.



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The steps ordinarily required before a new drug product may be marketed in the United States include preclinical
laboratory tests, animal tests and formulation studies; the submission to the FDA of a notice of claimed exemption for an investigational new drug, or IND, which must become effective before clinical testing may commence; and adequate and
well-controlled clinical trials to establish the safety and effectiveness of the drug for each indication for which FDA approval is sought. The following paragraphs provide a general overview of the approval process for a new drug.



Preclinical Testing



Preclinical tests include laboratory evaluation of product chemistry, formulation and
stability, as well as studies to evaluate toxicity in animals. The results of preclinical tests, together with manufacturing information and analytical data, are submitted as part of an IND application to the FDA.



Investigational new drug application



If a company wants to test a new drug in human patients, an IND must be prepared and
filed with the FDA to request FDA authorization to begin human testing of the drug. The IND application automatically becomes effective 30 days after receipt by the FDA, unless the FDA, within the 30-day time period, raises concerns or questions
about adequacy of the preclinical studies, the preclinical product characterization and/or the proposed conduct of the clinical trial, including concerns that human research subjects will be exposed to unreasonable health risks. In such a case, the
IND sponsor and the FDA must resolve any outstanding concerns before the clinical trial can begin. The submission of an IND may not result in FDA authorization to commence a clinical trial. A separate supplemental submission to an existing IND must
also be made for each successive clinical trial conducted during product development. Furthermore, an independent institutional review board, or IRB, for each medical center proposing to conduct the clinical trial must review and approve the plan
for any clinical trial before it commences at that center, and the IRB must monitor the trial until completed. The FDA, the IRB, or the sponsor may suspend a clinical trial at any time on various grounds, including a finding that the subjects or
patients are being exposed to an unacceptable health risk. Clinical testing also must satisfy extensive Good Clinical Practice, or GCP, regulations and regulations for obtaining informed consent from the trial subjects.



Clinical Trials



Clinical trials to support NDAs for marketing approval are typically conducted in three
sequential phases, Phases 1, 2 and 3, with Phase 4 studies conducted after marketing approval. Phase 4 trials are generally required for products that receive accelerated approval. These phases may be compressed, may overlap or may be omitted in
some circumstances.



| |  | Phase 1 Clinical Trials:    After an IND becomes effective, Phase 1 human clinical trials can begin. These studies are initially conducted in a limited
population to evaluate a drug candidates safety profile, and the range of safe dosages that can be administered to the patient, including the maximum tolerated dose that can be given to a patient with the target disease. Phase 1 studies also
determine how a drug candidate is absorbed, distributed, metabolized and excreted by the body, and its duration of action. In some cases, particularly in cancer trials, a sponsor may decide to run what is referred to as a Phase 1b
evaluation, which is a second safety-focused Phase 1 clinical trial typically designed to evaluate the impact of the drug candidate in combination with currently approved drugs.
| | - | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  | Phase 2 Clinical Trials:    Studies are generally conducted in a limited patient population to identify possible adverse effects and safety
risks, to determine the efficacy of the drug candidate for specific targeted indications and to determine dose tolerance and optimal dosage. Phase 2 clinical trials of cancer drugs typically are designed to evaluate the
| | - | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



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| | potential effectiveness of the drug on patients with specific types and stages of cancer and to further ascertain the safety of the drug at the dosage given in a
larger patient population. Multiple Phase 2 clinical trials may be conducted by the sponsor to obtain information prior to beginning larger and more expensive Phase 3 clinical trials. In some cases, a sponsor may decide to run what is referred to as
a Phase 2b evaluation, which is a second, confirmatory Phase 2 clinical trial that could, if positive and accepted by the FDA, serve as a registrational clinical trial in the approval of a drug candidate.
| | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  | Phase 3 Clinical Trials:    These are commonly referred to as registrational (or pivotal) studies, and are undertaken when Phase 2 clinical trials suggest
that a dose range of the drug candidate is effective and has an acceptable safety profile. In Phase 3 clinical trials, the drug is usually tested in a controlled randomized trial comparing the investigational new drug to an approved form of therapy
in an expanded and well defined patient population and at multiple clinical sites. The goal of these studies is to obtain definitive statistical evidence of safety and efficacy of the investigational new drug regimen as compared to an approved
standard treatment in defined patient populations with a given disease and stage of illness.
| | - | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



In the case of products for life-threatening diseases such as cancer, the initial human testing is often conducted in patients with the target disease rather than
in healthy volunteers. These studies may provide initial evidence of efficacy traditionally obtained in Phase 2 clinical trials, and so these trials are frequently referred to as Phase 1/2 trials.



In addition, a company may hold an End-of-Phase 2 Meeting with the FDA to
assess the safety of the drug regimen to be tested in the Phase 3 clinical trial, in part to evaluate the Phase 3 plan, and identifying any additional information that will be needed to support a new drug application. If the Phase 3 clinical trials
have been the subject of discussion at an End-of-Phase 2 Meeting, or in some cases if FDA is otherwise familiar with the drugs development program, the company is eligible for a Special Protocol Assessment, or SPA. The SPA is a
process by which the FDA must evaluate within 45 days the proposed Phase 3 protocols and any issues identified by the sponsor to assess whether the protocols are adequate to meet the agencys scientific and regulatory requirements.



Success in early stage clinical trials does not necessarily assure success in later
stage clinical trials. Data obtained from clinical activities is not always conclusive and may be subject to alternative interpretations that could delay, limit or even prevent regulatory approval.



New Drug Application



After successful completion of the required clinical testing of a drug candidate, an
NDA is prepared and submitted to the FDA. FDA approval of the NDA is required before marketing of the product may begin in the United States. The NDA must include the results of extensive clinical and other testing and a compilation of data relating
to the products pharmacology, chemistry, manufacture, and controls. The cost of preparing and submitting an NDA is substantial. Under federal law, the submission of NDAs is additionally subject to substantial application user fees, currently
$896,200 (for an application requiring clinical data), and the manufacturer and/or sponsor under an approved NDA are also subject to annual product and establishment user fees, currently $49,750 per product and $313,100 per establishment. These fees
are typically increased annually and the current fee structure will remain in place until September 30, 2007.



The FDA has 60 days from its receipt of a complete NDA to determine whether the application will be accepted for filing based on the agencys threshold
determination that the NDA is sufficiently complete to permit substantive review. Once the submission is accepted for filing, the FDA begins an in-depth review of the NDA. Under the Prescription Drug User Fee Act, or PDUFA, the FDA has agreed



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to specific performance goals in the review of NDAs. Most such applications for non-priority drug products are reviewed within ten months. The review process is often
significantly extended by FDA requests for additional information or clarification regarding information already provided in the submission. The FDA may also refer applications for novel drug products or drug products which present difficult
questions of safety or efficacy to an advisory committee, typically a panel that includes clinicians and other experts, for review, evaluation and a recommendation as to whether the application should be approved. The FDA is not bound by the
recommendation of an advisory committee.



If FDA evaluations of the NDA
and the manufacturing facilities are favorable, the FDA may issue an approval letter, or, in some cases, an approvable letter followed by an approval letter. An approvable letter generally contains a statement of specific conditions that must be met
in order to secure final approval of the NDA. If and when those conditions have been met to the FDAs satisfaction, the FDA will typically issue an approval letter. An approval letter authorizes commercial marketing of the drug with specific
prescribing information for specific indications. As a condition of NDA approval, the FDA may require post-approval testing and surveillance to monitor the drugs safety or efficacy and may impose other conditions, including labeling
restrictions which can materially impact the potential market and profitability of the drug. Once granted, product approvals may be withdrawn if compliance with regulatory standards is not maintained or problems are identified following initial
marketing.



If the FDAs evaluation of the NDA submission or
manufacturing facilities is not favorable, the FDA may refuse to approve the NDA or issue a not approvable letter. A not approvable letter outlines the deficiencies in the submission and often requires additional testing or information
in order for the FDA to reconsider the application. Even with submission of this additional information, the FDA ultimately may decide that the application does not satisfy the regulatory criteria for approval. With limited exceptions, the FDA may
withhold approval of an NDA regardless of prior advice it may have provided or commitments it may have made to the sponsor.



Fast Track Designation



The FDAs fast track program is intended to facilitate the development and to expedite the review of drugs that are intended for the treatment of a serious or
life- threatening condition for which there is no effective treatment and that demonstrate the potential to address unmet medical needs for the condition. Under the fast track program, the sponsor of a new drug candidate may request that FDA
designate the drug candidate for a specific indication as a fast track drug concurrent with or after the filing of the IND for the drug candidate. The FDA must determine whether the drug candidate qualifies for fast track designation within 60 days
of receipt of the sponsors request.



If fast track designation is
obtained, the FDA may initiate review of sections of an NDA before the application is complete. This rolling review is available if the applicant provides and the FDA approves a schedule for the submission of the remaining information and the
applicant pays applicable user fees. However, the time period specified in the PDUFA, which governs the time period goals the FDA has committed to reviewing an application, does not begin until the complete application is submitted. Additionally,
the fast track designation may be withdrawn by the FDA if the FDA believes that the designation is no longer supported by data emerging in the clinical trial process.



In some cases, a fast track designated drug candidate may also qualify for one or more of the following programs:



| |  | Priority Review.    Under FDA policies, a drug candidate is eligible for priority review, or review within a six-month time frame from the
time a complete NDA is accepted for filing, if the drug candidate provides a significant improvement compared to marketed drugs in the treatment, diagnosis or prevention of a disease. A fast track designated drug candidate would ordinarily meet the
FDAs criteria for priority review. We cannot guarantee any of our drug candidates will receive a priority review designation or, if a
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| | priority designation is received, that review or approval will be faster than conventional FDA procedures, or that the FDA will ultimately grant drug approval.
| | ---------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  | Accelerated Approval.    Under the FDAs accelerated approval regulations, the FDA is authorized to approve drug candidates that have been studied for
their safety and effectiveness in treating serious or life-threatening illnesses and that provide meaningful therapeutic benefit to patients over existing treatments based upon either a surrogate endpoint that is reasonably likely to predict
clinical benefit or on the basis of an effect on a clinical endpoint other than patient survival. In clinical trials, surrogate endpoints are alternative measurements of the symptoms of a disease or condition that are substituted for measurements of
observable clinical symptoms. A drug candidate approved on this basis is subject to rigorous post-marketing compliance requirements, including the completion of Phase 4 or post-approval clinical trials to validate the surrogate endpoint or confirm
the effect on the clinical endpoint. Failure to conduct required post-approval studies, or to validate a surrogate endpoint or confirm a clinical benefit during post- marketing studies, will allow the FDA to withdraw the drug from the market on
an expedited basis. All promotional materials for drug candidates approved under accelerated regulations are subject to prior review by the FDA.
| | - | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



Orphan Drug Designation



Orphan drug designation is designed to encourage manufacturers to develop drugs intended for a rare disease or condition. A rare disease or condition is statutorily
defined as one affecting fewer than 200,000 individuals in the United States, or one that affects more than 200,000 individuals in the United States and for which there is no reasonable expectation that the cost of developing and making available
the drug for the disease or condition will be recovered from sales of the drug in the United States. An application for designation as an orphan product can be made any time prior to the filing of an application for approval to market the
product.A drug becomes an orphan when it receives orphan designation from the Office of Orphan Products Development, or OOPD, at the FDA based on acceptable confidential requests made under the regulatory provisions. The drug
must then go through the new drug approval process like any other drug. Orphan drug designations are decided solely by the OOPD staff, but the OOPD occasionally will request opinions from the Center for Drug Evaluation and Research, especially when
dealing with issues such as the appropriateness of the requested indication or the scientific rationale described by the sponsor. More than one sponsor may receive orphan drug designation for the same drug for the same rare disease or condition, but
each sponsor seeking orphan drug designation must file a complete request for designation.



Orphan drug designation qualifies a company for incentives including tax credits and marketing exclusivity. A designated orphan product will have marketing exclusivity for seven years following the date of the drugs
marketing approval, provided the product is the first designated orphan to be approved for the designated indication.



A sponsor may request orphan drug designation of a previously unapproved drug, or of a new orphan indication for an already marketed drug. In addition, a drug that
is otherwise the same drug as an already approved orphan drug may be approved for marketing during the first products exclusivity period if the sponsor can show that its drug is clinically superior to the first drug.



The period of exclusivity begins on the date that the marketing application is approved
by the FDA and applies only to the indication for which the drug has been designated. During the orphan exclusivity period, the FDA can approve a second application for the same drug for a different use. The FDA cannot, however, approve the same
drug made by another manufacturer for the same indication during the marketing exclusivity period unless it has the consent of the sponsor or the sponsor is unable to provide sufficient quantities.



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Drug Price Competition and Patent Term Restoration Act of 1984



The Drug Price Competition and Patent Term Restoration Act of 1984, also known as the
Hatch-Waxman Act, established a regulatory framework designed to balance the incentives for innovative drug research with the opportunities for market entry of generic manufacturers. In order to achieve this balance, the Hatch-Waxman Act provided
for the restoration of patent terms based on the regulatory review period of a drug product, and data exclusivity periods following the FDA approval of an NDA, while allowing for the submission of simplified drug applications by generic
manufacturers. The simplified drug applications created by the Hatch-Waxman Act include two kinds of applications: (1) an abbreviated new drug application, or ANDA, which can rely on FDAs previous finding of safety and effectiveness for
the referenced innovator drug product, and (2) a new drug application for which the sponsor must submit full reports of clinical studies, some of which the sponsor does not own or have a legal right of reference. The latter type of application
is known as a Section 505(b)(2) application after its authorizing statutory provision. The patent and exclusivity status of the innovator drug product has implications for the review and approval of both ANDAs and Section 505(b)(2)
applications.



A key element of the Hatch-Waxman Act is the extension of
the life of a patent to compensate the innovator drug company for marketing time lost while developing the product and awaiting regulatory approval. The Act added Section 156 to the Patent Act permitting patent term extensions for patents on
products (or processes for making or using the same) including, but not limited to, drug products used to treat humans. The Hatch-Waxman Act allows only partial recovery of the patent term lost to regulatory approval requirements. In addition, the
statute imposes caps on term extension. The term of the patent eligible for extension equals one half of the IND testing phase and the full NDA review phase of testing required under the Federal Food, Drug, and Cosmetic Act. The IND testing phase is
measured as the time between the effective date of an IND and the date the FDA receives the NDA; the NDA review phase is the time between FDAs receipt of the NDA and approval of the NDA. However, any testing conducted prior to patent issuance
is not considered for patent extension. The maximum total patent term remaining after term extension is capped at fourteen years. Similarly, absolute caps limit the duration of term extension to five years. Furthermore, a patent is only eligible for
one term extension. This patent term extension is only available for the first commercial marketing of a given active ingredient. In addition, the product must have been subject to regulatory review before its commercial marketing or use, and the
resulting permission for commercial marketing or use must be the first granted. As a practical consequence, generally, only one patent may be extended per approved product. Also, the original patent must still be in force when the application for
term extension is filed, and the application must be filed by the patent owner of record or its agent. The application for patent term extension is subject to approval by the USPTO. The FDA, however, determines the length of the products
regulatory review period at the request of the USPTO. In some instances, the term of the patent for which a patent term extension is being requested may expire before such an extension is granted.



The Hatch-Waxman Act also provides for data exclusivity for the data demonstrating
safety and efficacy of a drug product as submitted in an NDA: five-year new chemical entity, or NCE, exclusivity and three-year new clinical trial exclusivity. Five-year NCE data exclusivity is granted to those drugs for which the active ingredient
is an active moiety (i.e., the molecule or ion responsible for physiological or pharmacological action, excluding appended portions that would cause the drug to be an ester, salt, or other noncovalent derivative of the molecule) not
previously approved by the FDA. Five-year NCE data exclusivity prohibits the FDA from accepting an ANDA or Section 505(b)(2) application for a drug product containing the same active moiety for a five-year period beginning from the date of
approval of the NDA. The only exception to this prohibition is if a generic competitor challenges patents listed in the Orange Book for the drug product at the end of four years. The five-year exclusivity provision, however, does not prohibit the
FDA from accepting another full NDA, for example from a competitor, if the sponsor of the second application has done all the work itself. The



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FDA can accept the second application, review it, and approve it; NCE exclusivity only prohibits the agency from accepting a Section 505(b)(2) application or an
ANDA.



Three-year clinical trial data exclusivity is granted for certain
changes in a drug product, for which the NDA or supplement contains reports of new clinical studies in humans conducted by the sponsor that are essential to approval. This data exclusivity covers only the change in the product supported by the new
clinical studies. If there are other indications not covered by any patent or exclusivity, and available for competition, generic drugs can be approved for those indications. A grant of three years of data exclusivity to a drug product means the FDA
cannot approve a Section 505(b)(2) application or an ANDA for the same product for three years. Unlike the five-year data exclusivity, the agency can accept such an application and review it during this time period. Like NCE data exclusivity,
this data exclusivity will not bar approval of a full NDA where the applicant has done the work to support the same change for the drug product. Data exclusivities are also published in the Orange Book.



The Hatch-Waxman Act requires an applicant for an ANDA to submit a certification for
each patent listed in the Orange Book. This certification requirement also extends to Section 505(b)(2) applications. One of four certifications must be made: 1) that the drug has not been patented; 2) that the patent has already expired; 3)
the date on which the patent will expire, and that the generic drug will not go on the market until that date passes; and 4) that the patent is not infringed or is invalid. Those certifications are now referred to as paragraph I, II, III, or IV
certifications. Whereas the first three certifications are relatively straightforward, the paragraph IV certification presents added requirements.



When an ANDA contains a paragraph IV certification, the applicant is required to notify the innovator company that it has filed the ANDA with the FDA, and describe
the reasons it believes the patent will not be infringed, is invalid, or is unenforceable. The only exception to this rule is if a company is not seeking approval for one of the drugs uses. In that case, an applicant may submit a Section
8 statement that the company is not seeking approval for a particular use. Once the innovator company receives notice that a generic application has been filed and its patent is being challenged, the innovator drug company has 45 days in which
to file a lawsuit claiming patent infringement based on the generic drug companys assertion about the characteristics of its proposed product. The filing of a lawsuit as a result of the paragraph IV notice has a substantial effect on the time
of approval of the ANDA or 505(b)(2) application. If a lawsuit is brought by the innovator drug company, the FDAs final approval is stayed for 30 months. If the patent court determines that the patent would be infringed by the product proposed
in the ANDA or 505(b)(2) application, the FDA will not approve the application until the patent expires. If the court decides that the patent will not be infringed, or is invalid, the FDA may approve the generic application when that decision
occurs. The FDA may approve the application at the thirty-month date, even if the litigation is ongoing. If litigation is pending and the agency approves an ANDA at the end of the 30-month period, most generic drug companies seem unwilling to risk
liability for damages by bringing a generic drug product onto the market before the patent litigation is resolved. A generic applicant who is the first to challenge a listed patent using a paragraph IV certification is granted a 180-day exclusivity
period with respect to other generic applicants. This exclusivity period provides generic applicants with an incentive by which to challenge listed patents for the innovator drug product.



Under the provisions of the Medicare Prescription Drug Improvement and Modernization Act of 2003, the patent owner and the NDA holder
have the opportunity to trigger only a single 30-month stay per abbreviated new drug application or Section 505(b)(2) application.



Post-Marketing Studies



As a condition of NDA approval, the FDA may require post-marketing Phase 4 clinical trials to confirm that the drug is safe and effective for its
intended uses. Where drugs are approved under



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accelerated approval regulations or are otherwise approved for a life-threatening condition, additional studies will likely be required to document a clinical benefit
and monitor the long-term effects of the therapy. Under the provisions of the FDA Amendments Act of 2007, these post marketing requirements may be mandatory



Other Regulatory Requirements



Any products we manufacture or distribute under FDA approvals are subject to pervasive and continuing regulation by the FDA, including record-keeping requirements
and reporting of adverse experiences with the products. Drug manufacturers and their subcontractors are required to register with the FDA and, where appropriate, state agencies, and are subject to periodic unannounced inspections by the FDA and
state agencies for cGMPs, which impose procedural and documentation requirements upon us and any third-party manufacturers we utilize. Failure to comply with the statutory and regulatory requirements can subject a manufacturer to possible legal or
regulatory action, such as warning letters, suspension of manufacturing, seizure of product, injunctive action or possible civil penalties. We cannot be certain that we or our present or future third-party manufacturers or suppliers will be able to
comply with the cGMP regulations and other ongoing FDA regulatory requirements. If our present or future third-party manufacturers or suppliers are not able to comply with these requirements, the FDA may halt our clinical trials, require us to
recall a drug from distribution, or withdraw approval of the NDA for that drug.



FDA Regulation of Post-Approval Marketing and Promotion



The FDA closely regulates the post-approval marketing and promotion of drugs, including standards and regulations for direct-to-consumer advertising, off-label promotion, industry-sponsored scientific and educational activities and
promotional activities involving the internet. A companys claims relating to safety and efficacy must be consistent with the FDA-approved labeling. Failure to comply with these requirements can result in adverse publicity, warning letters,
corrective advertising and potential civil and criminal penalties. Physicians may prescribe legally available drugs for uses that are not described in the drugs labeling and that differ from those tested by us and approved by the FDA. Such
off-label uses are common across medical specialties. Physicians may believe that such off-label uses are the best treatment for many patients in varied circumstances. The FDA does not regulate the behavior of physicians in their choice of
treatments. The FDA does, however, impose stringent restrictions on manufacturers communications regarding off-label uses.



From time to time, including presently, legislation is drafted and introduced in Congress that could significantly change the statutory provisions governing the
approval, manufacturing and marketing of drug products. In addition, FDA regulations and guidance are often revised or reinterpreted by the agency in ways that may significantly affect our business and our products. It is impossible to predict
whether legislative changes will be enacted, or FDA regulations, guidance or interpretations changed, or what the impact of such changes, if any, may be.



Regulation in the European Union



Clinical trials in Europe proceed in much the same manner as they do in the United States, requiring Phase 1, 2, and 3 trials, as well as Phase 4 trials that take
place after market approval in order to gather data on an approved product.



The Clinical Trials Directive establishes a system for the approval of clinical trials in the EU. Similar to the IND system in the United States, under this new system, approval must be obtained from the national regulatory agency of an EU
Member State in which the trial is planned to be conducted. For this clinical trial application, an Investigational Medicinal Product Dossier must be submitted. While the Clinical Trial Directive permits a maximum review period of 60 days, this
period is shorter in some



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Member States. In Germany for example, for most drugs, the national agency has 30 days to raise questions about the application. Approval is deemed to be given if
notice of objection is not given within the relevant time limit, but for certain products, including biotechnology compounds such as monoclonal antibodies, written approval may be required under the national rules, and for other types of products,
such as gene and cell therapy, written approval is always needed. In addition, approval must also be obtained from the responsible ethics committees (equivalent to the IRB in the United States).



Drug approval in the Member States of the European Union generally proceeds under one
of three approval procedures: a centralized approval procedure, a decentralized procedure, and a so-called mutual recognition procedure. The centralized approval procedure is mandatory for biotechnology products and certain other high-technology
products, such as new cancer drugs. Celgene seeks approval for satraplain in the European Union under this centralized procedure. The London-based EMEA and the European Commission in Brussels govern the centralized drug registration and approval
process. Under this centralized procedure, an approval of a new drug application by the European Commission allows a company to market its drug product in all Member States of the European Union, without having to obtain separate approvals from each
Member State. However, marketing remains subject to national pricing and reimbursement rules from each Member State that often delay marketing and can sometimes effectively prevent it.



In contrast, a company may pursue a decentralized procedure or a mutual recognition procedure to obtain mutual recognition of a new
drug assessment by the Member States. Under the mutual recognition procedure, an applicant can go directly to a national marketing authority to obtain permission to market its product in the Member State and then seek to have other Member States
accept the marketing approval of the first Member State. Under the decentralized procedure, which is very similar to the mutual recognition procedure, an applicant can go simultaneously to several national marketing authorities to obtain permission
to market its product in the Member State and select the national authority that will take the lead for the scientific assessment of the product. National pricing and reimbursement rules will also apply to companies following the decentralized or
mutual recognition procedure, and therefore marketing delays may occur.



Under the centralized approval procedure, the EMEAs Committee for Medicinal Products for Human Use, composed primarily of experts nominated by each Member States national marketing authority, serves as the scientific committee
that renders opinions about the safety, efficacy, and quality of human drug products. Each Member State of the European Union has two members on the committee.



Once an application is submitted to the EMEA, the EMEA ensures that the application is complete, and then selects two of its members, known as rapporteurs, to
perform independent scientific evaluations of the safety, efficacy, and quality of the drug product candidate. The rapporteurs can draw on two sources of European Union-wide scientific expertise in forming their review teamsexperts from the
national marketing authorities of Member States and any of over 1,000 outside experts located at universities and institutions throughout Europe. Once the rapporteurs have completed their respective evaluations, they present the case to the EMEA
Committee, which then must render an opinion within 210 days after the application was submitted (subject to certain administrative delays). However, for drugs that are of major interest for public health, the applicant may request an accelerated
assessment. If granted, such request reduces the deadline from 210 to 150 days. The 210-day deadline may also be postponed when the reviewers request additional information from the applicant and under new rules, further extensions are possible. If
the EMEA Committee opinion is favorable, it is transferred to the applicant, all Member States, and the European Commission. The European Commission uses the EMEA Committees opinion to prepare a draft decision. This draft decision is then
finalized in cooperation with the Standing Committee (composed of



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representatives of the Member States), which generally agrees to the draft. The rules also allow for a conditional approval of products for treatment of very serious
conditions when there is an unmet medical need. The approval can be granted without full pre-clinical and clinical data being available and is subject to specific obligations. It needs to be renewed annually until it is converted into a standard
approval, when all the obligations are fulfilled.



Products approved via
the centralized authorization procedure in the past received a regulatory data protection of ten years. For products approved via the decentralized or mutual recognition procedure, data exclusivity ranged from six to ten years (or six years but
limited to patent life) in individual Member States. However, new, harmonized data exclusivity periods have been adopted, which apply to products for which applications for approval have been filed on and after November 20, 2005, for products
to be approved under the centralized procedure, and on and after October 30, 2005, for products to be approved under the decentralized or mutual recognition procedure. These products benefit from a two-tier regulatory protection. A third party
may only reference the preclinical and clinical data of the originator after eight years (eight years data exclusivity), and can only market a generic version after ten years have lapsed (two years of marketing protection). The protection period of
eight plus two years can be extended by another year in case of a new therapeutic indication that is of significant benefit. If satraplatin is approved in the European Union, it will be covered by the new rules.



A drug may also qualify for an orphan medicinal product, or OMP, designation in the
European Union. An application for designation as an OMP must be submitted prior to submission of an application for marketing approval. OMP designation qualifies a drug for up to ten years of market exclusivity (against approval of products with
the same or a very similar active substance for the relevant indication) once the drug is approved. OMP designations are issued by the European Commission, acting on the advice of an expert committee, with representatives of the Member States,
patient organizations, and other interests. OMP designation will be granted if the product meets either of two tests: one based on prevalence criteria (the disease or condition must affect no more than five per 10,000 persons in the European Union);
and the other based on a determination that it would be infeasible economically to develop the product without orphan drug incentives. The second condition allows the OMP designation to be given to products for diseases for which treatments are not
likely to be commercially viable. In addition, it must be shown that there is no satisfactory authorized method for diagnosis, prevention or treatment of the respective disease in the European Union. However, if a medicinal product is deemed orphan
and if there is a satisfactory alternative already approved in a European Member State, then the product is eligible for an OMP designation if it is of significant benefit to patients. During the development and regulatory review phase, the orphan
drug status can be lost if the designation criteria are not met anymore, for instance because a new treatment for the disease in question is approved.



Although orphan drug exclusivity in the EU is initially granted for ten years, at the end of the fifth year, any Member State can initiate proceedings to restrict
that period to six years if it believes that the criteria for orphan designation no longer apply (e.g., because the prevalence of the disease has increased or the manufacturer is earning a sufficient profit not to maintain the exclusivity). This
provision has not yet been applied. In addition, competitive products can be approved during the marketing exclusivity period, for example, if they are not similar to the original product or are safer, more effective, or otherwise
clinically superior to it.



A new pediatric regime was established in
December 2006 and started taking effect in July 2007. It imposes an obligation to develop pediatric data for new products (mandatory for filings from July 26, 2008) and for most line extensions for patented products (mandatory for filings from
January 26, 2009) unless specific exemptions are granted. In return, a reward of six months of additional patent extension (through an extension of the supplementary protection certificate) or, for orphan drugs, two years of market exclusivity,
may be available.



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Regulation in Other Countries



Approval of a product by comparable regulatory authorities may be necessary in foreign countries prior to the commencement of marketing of the product in those
countries, whether or not FDA or EMEA approval has been obtained. The approval procedure varies among countries and can involve requirements for additional testing. The time required may differ from that required for FDA or EMEA approval. Although
there are some procedures for unified filings for some European countries with the sponsorship of the country that first granted marketing approval, in general each country has its own procedures and requirements, many of which are time consuming
and expensive. Thus, there can be substantial delays in obtaining required approvals from foreign regulatory authorities after the relevant applications are filed. Several years ago, representatives of the regulators in the United States, the
European Union and Japan launched the International Conference on Harmonization (ICH), a collaborative effort with the goal of streamlining the development and registration of medicinal products by harmonizing the applicable procedures
in the three regions. For the foreseeable future, however, we will have to seek separate approval in each region.



German Corporate Law



We are a German stock corporation and subject to German law, which may differ from the law governing U.S. public companies in certain key areas described below:



All public offers for the acquisition of shares, securities comparable
to shares and certificates representing shares, such as ADSs, as well as bids for other types of securities representing the right to acquire shares, securities comparable to shares and certificates representing shares are subject to the provisions
of German takeover laws. In particular, the creation or transfer, directly or indirectly, of 30% or more of the voting rights in a public German stock corporation generally triggers the obligation to launch a mandatory bid for all outstanding shares
in that German stock corporation.



Under German law, certain important
resolutions, such as resolutions relating to changes in the articles of association of a German stock corporation, any increases or decreases in a German stock corporations share capital, the issuance of convertible bonds or bonds with
warrants attached and the dissolution of the German stock corporation apart from insolvency and certain other proceedings, require a 75% majority of the votes present or represented at the shareholders meeting. Therefore, the holder or holders
of a blocking minority of 25% or, depending on the attendance level at the shareholders meeting, the holder or holders of a smaller percentage of the shares in a German stock corporation may be able to block any such votes, possibly to the
detriment of the German stock corporation and the other shareholders.



As
a general rule under German corporate law, until the amendments to, among others, the German Stock Corporation Act came into effect on November 1, 2005 as a result of the Law on Enterprise Integrity and the Modernization of Avoidance Rules
(Gesetz zur Unternehmensintegrität und Modernisierung des Anfechtungsrechts), shareholders had no direct recourse against the members of the management board or supervisory board of a German stock corporation in the event that it is
alleged they have breached their duty of loyalty and care to the German stock corporation. Effective November 1, 2005, however, shareholders holding at least 1% of the share capital or a portion of the share capital of at least 100,000 in a German stock corporation may now petition the competent district court (Landgericht) to admit damages claims directly against the members of the
management board or supervisory board of a German stock corporation to be brought by the shareholders in the event of any alleged breaches of duty. As part of this claim admission process (Klagezulassungsverfahren), shareholders wishing to
bring claims directly against the board members of a German stock corporation must submit proof to the competent court that (1) they have acquired their shares before they were deemed to have learned, due to public disclosure, of the alleged
breach



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of duty of loyalty and care, (2) the shareholders had requested the German stock corporation in vain to file the relevant claim itself, (3) there are facts
that justify the suspicion that the German stock corporation has suffered damages as a result of dishonesty (Unredlichkeit) or gross violations (grober Verstoß) of the law or the stock corporations articles of association
and (4) there are no predominant interests of the stock corporation that would prohibit the bringing of any damages claim. In addition, once the competent court has admitted the claim to be brought by shareholders, any such claim may only be
brought within three months of the relevant court decision and only if the shareholders have again requested the German stock corporation in vain to file the relevant claim. Also, note that the German stock corporation may, at any time, not only
file the relevant claim itself (thus making the shareholders claim (retroactively) impermissible) but may also assume a pending claim initially brought by shareholders at its then current stage.



Our Subsidiary



The following table presents selected information relating to our sole subsidiary as of December 31, 2007 (in thousands of , except for share of capital).



|                                                                             |  |                        |  |             |  |                |   |  |        |  |                 |   |  |                         
|---------------------------------------------------------------------------- |  | ---------------------- |  | ----------- |  | -------------- | - |  | ------ |  | --------------- | - |  | ------------------------
|Name and location of the entity                                              |  | PrimaryActivity        |  | CommonStock |  | ShareofCapital |   |  | Equity |  | Netincome(loss) |   |  | Liabilitiesowed byparent
|GPC Biotech Inc., Waltham, Massachusetts, USA and Princeton, New Jersey, USA |  | researchanddevelopment |  | 20,684      |  | 100            | % |  | 14,134 |  | (29,130         | ) |  | 2,175                   



Hazardous Materials



Our research and development processes involve the controlled use of hazardous
materials, chemicals and radioactive materials and produce waste products. We are subject to federal, state and local laws and regulations governing the use, manufacture, storage, handling and disposal of hazardous materials and waste products. We
do not expect the cost of complying with these laws and regulations to be material.



Facilities



After our recent reductions in head-count, we
were able to down-size our leased space in both Martinsried/Planegg in Germany and in Princeton, NJ, USA. Our headquarters are located in Martinsried/Planegg, Germany. We lease approximately 4132 square meters (16,867 square feet) in this facility,
in which we house our corporate offices under an operating lease expiring May 31, 2015. This lease extends automatically on May 31st of each year thereafter for one additional year unless terminated by either party with twelve months
notice. Additionally, beginning as of November 30, 2009, we may terminate the lease on six months notice.



As of the date of this report, we lease approximately 15,784 square feet of office space in a facility in Princeton, New Jersey under an operating lease expiring on
July 1, 2013, with an option to terminate (upon 6 months written notice) on July 1, 2011.



Item 4A. Unresolved Staff Comments



Not applicable.



46



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##### Table of Contents

Item 5. Operating and Financial Review and Prospects



You should read the following discussion of our financial condition and results of
operations in conjunction with the consolidated financial statements and the notes to our financial statements included elsewhere in this annual report. This discussion contains forward-looking statements that involve risks, uncertainties and
assumptions and you should refer to our description of the treatment of such statements and how to identify them in Forward-Looking Statements in the beginning of this annual report. As a result of many factors, including those set forth
under the section entitled Risk Factors and elsewhere in this annual report, our actual results may differ materially from those anticipated in these forward-looking statements.



Where necessary, certain prior year amounts in this section have been reclassified to
conform with the current year presentation.



Overview of Business



GPC Biotech is a biopharmaceutical company focused on anticancer drugs. Our lead
product candidate is satraplatin, an oral platinum compound. We have various anti-cancer programs in research and development that leverage our expertise in kinase inhibitors. GPC Biotech AG is headquartered in Martinsried/Munich (Germany) and has a
wholly owned U.S. subsidiary in Princeton, New Jersey.



The year 2007 was
a challenging year for GPC Biotech, with a major setback involving the results of the Phase 3 trial for satraplatin discussed below. In late 2007, however, we implemented a revised strategic plan and are currently seeking to rebuild the Company by
moving what we believe are our most promising development programs forward and pursuing opportunities to combine with or acquire other companies that could complement our own programs and expand our asset portfolio.



Satraplatin



In February 2007, we completed a New Drug Application (NDA) submission for satraplatin based on the results of a Phase 3 trial, called
the SPARC trial, in second-line hormone refractory prostate cancer. The results showed a statistically significant improvement in progression-free survival. Based on these results, we requested accelerated approval in the U.S. for satraplatin. That
submission was accepted by the FDA and granted priority review status. In July 2007, an FDA advisory panel recommended that the agency await the final overall survival results from the trial before determining if the satraplatin NDA submission was
approvable. Based on this recommendation, we withdrew the satraplatin NDA. In late October 2007, we announced that satraplatin did not demonstrate an improvement in overall survival in the intent-to-treat patient population in the SPARC trial.



In Europe, our partner Pharmion GmbH (now Celgene Corporation),
submitted a Marketing Authorization Application (MAA) for satraplatin in mid-2007. That submission was accepted by the European Medicines Agency (EMEA) and a decision on the filing is expected in the second half of 2008. See also: Item 3D
Risk FactorsSatraplatin may never receive regulatory approval in the United States or Europe and may never be successfully commercialized and you may lose all or a substantial part of your investment.



In June 2007, we announced a partnership for satraplatin in Japan with Yakult Honsha
Co. Ltd. (Yakult). Under the terms of the agreement, Yakult gained exclusive commercialization rights to satraplatin for Japan and took the lead in developing the drug in that country.



47



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##### Table of Contents

Following the disappointing overall survival results from the SPARC trial, we conducted extensive analyses of the
data to gain a better understanding of the overall survival results. We also evaluated all ongoing and planned trials with satraplatin and decided to stop some trials and continue others. In addition, we have been exploring potential alternative
registrational paths for satraplatin with our partners and cooperative oncology groups who might be interested in leading studies.



Other development programs



We have two kinase inhibitor compounds in pre-clinical development. Pre-clinical work for the most advanced of these compounds, RGB-286638, has been completed, and
we expect to begin Phase 1 clinical testing in the second half of 2008. Testing in cancer cells has shown that RGB-286638 leads to cell cycle inhibition and induces apoptosis (programmed cell death), key elements in stopping the spread of cancer
cells. Data in animal tumor models show that use of RGB-286638 results in tumor regression and increases survival time.



A second drug candidate, RGB-344064, is undergoing the necessary pre-clinical testing to move this compound into the clinic. RGB-344064, has been shown to
selectively inhibit all key Cdks.



In February 2008, we announced
that we had decided to discontinue internal development of our monoclonal antibody, 1D09C3, which was in Phase 1 clinical testing for relapsed/refractory B-cell lymphomas.



Corporate



In May 2007, we announced our decision to consolidate our drug discovery efforts to one location. This consolidation involved closing our facility in Waltham,
Massachusetts.



In August 2007, following the withdrawal of the NDA for
satraplatin, we implemented a corporate restructuring that included staff reductions in the U.S. We implemented another restructuring in November 2007 after we learned of the overall survival results from the SPARC trial that involved significant
staff reductions in both the U.S. and Munich, as well as a re-evaluation of our programs.



Effective January 1, 2008, GPC Biotech appointed Torsten Hombeck, Ph.D. to Chief Financial Officer. Dr. Hombeck joined GPC Biotech in 1999 and was previously Vice President, Finance. He replaced Mirko Scherer,
Ph.D., who left the Company at the end of 2007.



In February 2008, we
announced an additional corporate restructuring to sharpen our focus on oncology clinical development efforts and to further reduce costs. The restructuring was mainly focused on our early-stage research activities in Munich. The combined
restructuring activities in 2007 and February 2008 resulted in a reduction of approximately 71% of the total workforce which consisted of approximately 336 employees in the first half of 2007. For more information about the financial impact of the
restructurings please refer to Footnote 10 of our financial statements on page F-25.



As part of the February 2008 restructuring, we announced that, by mutual consent, Elmar Maier, Ph.D., Chief Operating Officer/Martinsried and Senior Vice President, Business Development, and Sebastian Meier-Ewert, Ph.D., Senior
Vice President and Chief Scientific Officer left the Management Board of the Company. Both Dr. Maier and Dr. Meier-Ewert remain available to the Company as advisors.



We are actively exploring potential mergers and acquisitions (M&A), as well as possible in-licensing opportunities in part to fill
our oncology development pipeline.



48



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##### Table of Contents

In past years, we have funded our operations primarily through the issuance of equity securities, payments received
under our collaboration and license agreements with other pharmaceutical companies, interest earned on investments and other sources of funding. Management expects to continue to fund the Companys operations over the next several years
primarily through our existing cash resources and marketable securities, sales of equity and debt securities, potential future payments from co-development and licensing partners as well as interest earned on investments.



At December 31, 2007, we held  49.7 million in cash and cash equivalents and  14.1 million in short-term investments and
marketable securities. In addition, we also had  1.4 million in restricted cash at that date. We expect these cash reserves to be sufficient to fund currently
planned business operations until approximately the end of 2010.



Overview of 2007
Results



During 2007, the Company completed an NDA submission for
satraplatin, and began developing the infrastructure for the commercialization of the product. Following the disappointing overall survival results from the SPARC trial, GPC Biotech began the process of implementing a new strategic plan. During
2007, approximately  4.2 million of restructuring charges were expensed to general and administrative expenses, or G&A, and research and development, or
R&D, as a result of this process.



| |  |  | Revenue decreased 19%.
| | - |  | ----------------------



| |  |  | Revenues decreased in 2007 primarily due to a decrease in payments from Pharmion (now Celgene Corporation) relating to the co-development and license agreement for
satraplatin as the SPARC Phase 3 trial was mostly completed in 2007.
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | Research and development expense decreased 21%.
| | - |  | -----------------------------------------------



| |  |  | Drug development activities decreased, mostly related to the SPARC trial, which was near completion in 2007.
| | - |  | ------------------------------------------------------------------------------------------------------------



| |  |  | Cash and cash equivalents increased  11.3 million.
| | - |  | ---------------------------------------------------



| |  |  |  66.7 million used in operations and  1.6 million invested in property and equipment were offset by net proceeds of  40.4 million from the issuance
of shares and the exercise of employee stock options and convertible bonds.
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | Other offsetting items include  42.3 million of additional cash from the net
proceeds on the sale of marketable securities and short term investments.
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------



Capital Expenditures



The following table sets forth our
capital expenditures in fiscal years 2007, 2006 and 2005 (in thousand )



|                                 |  |                               |  |       |  |      
|-------------------------------- |  | ----------------------------- |  | ----- |  | -----
|                                 |  | Fiscal Year endedDecember 31,
|                                 |  | 2007                          |  | 2006  |  | 2005 
|Property, equipment and licenses |  | 1,581                         |  | 1,878 |  | 4,549
|                                 |  |                              
|Total                            |  | 1,581                         |  | 1,878 |  | 4,549
|                                 |  |                              



We finance our current capital
expenditures out of our cash resources. Of our total capital expenditures in fiscal years 2007, 2006 and 2005, 47.0%, 50.0% and 17.2%, respectively, were invested in the United States, with the remaining balance invested in Germany. There are
currently no significant capital expenditures in progress.



49



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##### Table of Contents

Results of Operations and Related Information



This section contains a discussion and analysis of revenue, research and development, general and administrative expenses and other information
relevant to an understanding of 2007 results of operations. This discussion and analysis compares 2007 results to 2006 and 2006 results to 2005. Each of those discussions focuses on consolidated results. The Company operates in only one business
segment.



Analysis of Revenues



All of our product candidates are currently in development. With respect to our most
advanced product candidate, satraplatin, our partner Pharmion (now Celgene) submitted an MAA for satraplatin in mid-2007. That submission was accepted by the EMEA and a decision on the filing is expected in the second half of 2008. If approved, the
Company may begin to receive royalty and certain milestone payments. However, for the reasons stated in Risk Factors, marketing approval in Europe may be delayed or may not be achieved at all.



Any delay in obtaining or failure to obtain regulatory approval for satraplatin may
materially adversely affect our ability to generate revenues from milestone payments and royalties in the next several years (see also the information in Risk Factors.)



With respect to our other product candidates, we are currently unable to determine when, if ever, we might be able to generate revenue
from them, given the early stage of their development and the uncertainties associated with drug development in general.



A substantial portion of our historical revenue was generated from Pharmion and, earlier, from our alliance with ALTANA Pharma. In accordance with our agreements
with ALTANA Pharma, the revenue generated decreased in 2007 as all of our contracts terminated as planned. We expect no future revenues from this alliance.



During 2007, we recognized co-development revenues from the agreement with Pharmion in the form of payments of shared development costs and amortization of certain
upfront payments received.



Pharmion and ALTANA Pharma accounted for 89%
and 9%, respectively, of our 2007 revenues. In 2006, Pharmion and ALTANA Pharma accounted for 66% and 31% of the Companys revenues, respectively.



2007 vs. 2006



Revenues for the year ended December 31, 2007, decreased by approximately 19% to  18.3 million, from  22.7 million for the year ended December 31, 2006. The following table summarizes our revenues for the years
ended December 31, 2007 and 2006 (in millions of , except % change):



|                                                                                             |  |      |  |      |  |        |   |  |          |   
|-------------------------------------------------------------------------------------------- |  | ---- |  | ---- |  | ------ | - |  | -------- | --
|                                                                                             |  | 2007 |  | 2006 |  | Change |   |  | % Change |   
|Co-development revenue and amortization of deferred upfront payments and annual license fees |  | 11.6 |  | 20.3 |  | (8.7   | ) |  | (42.9    | )%
|FTE Services                                                                                 |  |     |  | 0.6  |  | (0.6   | ) |  | (100.0   | )%
|Milestones                                                                                   |  | 6.4  |  | 1.4  |  | 5.0    |   |  | 357.1    | % 
|Grants                                                                                       |  | 0.3  |  | 0.4  |  | (0.1   | ) |  | (25.0    | )%
|                                                                                             |  |      | 
|Total                                                                                        |  | 18.3 |  | 22.7 |  | (4.4   | ) |  | (19.4    | )%
|                                                                                             |  |      | 



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##### Table of Contents

Co-development revenue and amortization of deferred upfront payments and annual license fees decreased 43% from
2006. This decrease is primarily due to a decrease in payments from Pharmion relating to the co-development and license agreement for satraplatin as the SPARC Phase 3 trial was mostly completed in 2007.



Milestone revenues increased 357% during 2007. This increase is due to the timing of
the achievement of certain milestones relating to our co-development and license agreement with Pharmion.



2006 vs. 2005



Revenues for the year ended December 31, 2006, increased by approximately 144% to  22.7 million, from  9.3 million for the year ended December 31, 2005. The following table summarizes our revenues for the years
ended December 31, 2006 and 2005 (in millions of , except % change):



|                                                                                             |  |      |  |      |  |        |   |  |          |   
|-------------------------------------------------------------------------------------------- |  | ---- |  | ---- |  | ------ | - |  | -------- | --
|                                                                                             |  | 2006 |  | 2005 |  | Change |   |  | % Change |   
|Co-development revenue and amortization of deferred upfront payments and annual license fees |  | 20.3 |  | 6.2  |  | 14.1   |   |  | 227.4    | % 
|FTE Services                                                                                 |  | 0.6  |  | 1.1  |  | (0.5   | ) |  | (45.5    | )%
|Milestones                                                                                   |  | 1.4  |  | 2.0  |  | (0.6   | ) |  | (30.0    | )%
|Grants                                                                                       |  | 0.4  |  |     |  | 0.4    |   |  | 100      | % 
|                                                                                             |  |      | 
|Total                                                                                        |  | 22.7 |  | 9.3  |  | 13.4   |   |  | 144.1    | % 
|                                                                                             |  |      | 



Co-development revenue and
amortization of deferred upfront payments and annual license fees increased 227% from 2005. This increase is primarily the result of monies received under our co-development and license agreement with Pharmion.



Full Time Equivalent, or FTE, services decreased 45.5% as fewer resources were utilized
in the research collaboration with ALTANA Pharma in 2006. This decrease is in accordance with the research plan set forth at the initiation of the research collaboration. The term of the agreement expired in June 2007.



Milestone revenues decreased 30.0% during 2006. This decrease is due to the timing of
the achievement of milestones under our ALTANA Pharma agreements.



Grant
revenues increased from  0 to  0.4 million during 2006 as we received
government grants for certain research and development projects.



Analysis of Operating Loss



Research and Development
Expenses



We incur development expenses related to our clinical and
preclinical drug development programs. We also incur research expenses associated with both partnered and unpartnered research and discovery activities, as well as the development and maintenance of our drug discovery technologies. We have incurred
approximately 3000 hours of time annually on sponsored research R&D activities in each of 2007, 2006 and 2005.



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##### Table of Contents

The following table summarizes the costs of significant projects and other costs comprising to arrive at total
research and development expenses for the periods shown (in thousands of ):



|                                                                  |  |                         |  |        |  |        |  |           |  |               
|----------------------------------------------------------------- |  | ----------------------- |  | ------ |  | ------ |  | --------- |  | --------------
|                                                                  |  | Year ended December 31,
|                                                                  |  | 2007                    |  | 2006   |  | 2005   |  | 2002-2004 |  | Total2002-2007
|Project Costs:                                                    |  |                         |  |        |  |        |  |           |  |               
|Satraplatin                                                       |  | 20,783                  |  | 29,817 |  | 23,087 |  | 27,307    |  | 100,994       
|1D09C3                                                            |  | 2,808                   |  | 1,374  |  | 1,660  |  | 8,641     |  | 14,483        
|Cell Cycle Inhibitors                                             |  | 1,709                   |  | 2,478  |  | 1,512  |  | 1,677     |  | 7,376         
|Cost of performing research and development for others            |  |                        |  | 249    |  | 910    |  | 8,660     |  | 9,819         
|Other projects                                                    |  | 4,537                   |  | 7,507  |  | 6,963  |  | 19,076    |  | 38,083        
|                                                                  |  |                        
|Total project cost                                                |  | 29,837                  |  | 41,425 |  | 34,132 |  | 65,361    |  | 170,755       
|Other costs to arrive at total research and development expenses: |  |                         |  |        |  |        |  |           |  |               
|Benefits and other salaries                                       |  | 10,016                  |  | 11,071 |  | 7,419  |  | 19,145    |  | 47,651        
|Stock-based compensation                                          |  | 1,354                   |  | 2,876  |  | 3,259  |  | 5,947     |  | 13,436        
|Building and facilities                                           |  | 3,505                   |  | 3,098  |  | 3,468  |  | 10,673    |  | 20,744        
|Depreciation                                                      |  | 1,111                   |  | 1,323  |  | 3,350  |  | 4,518     |  | 10,302        
|Intellectual property expenses                                    |  |                        |  | 518    |  | 593    |  | 3,356     |  | 4,467         
|Other expenses                                                    |  | 5,614                   |  | 4,396  |  | 3,463  |  | 6,543     |  | 20,016        
|                                                                  |  |                        
|Total research and development expenses                           |  | 51,437                  |  | 64,707 |  | 55,684 |  | 115,543   |  | 287,371       
|                                                                  |  |                        



Project costs shown in the table
above include direct project costs plus the salaries of the employees who directly charged time to the project and do not include overhead and other unallocated costs.



Satraplatin project expenses accounted for the largest portion of research and development expenses during 2007, 2006 and 2005. Under our
co-development and license agreement with Pharmion (now Celgene) for satraplatin, future development costs continue to be partially shared. In 2006, we deemed the acceptance of the NDA and MAA filings for satraplatin to be probable and therefore
accrued a total of $6.0 million in the third quarter of 2006 related to milestone payments we owed Spectrum Pharmaceuticals, Inc. upon occurrence of these milestone events. The FDA accepted the NDA filing in April of 2007 and this resulted in the
payment of $4.0 million in May 2007 out of the total amount accrued. In July 2007, the EMEA accepted for filing the MAA for satraplatin. As a result, we received a  5.9 million milestone payment from Pharmion. Also, the acceptance of the MAA by the EMEA triggered payments by us to Spectrum in the total amount of approximately  2.4 million, representing a direct milestone payment plus Spectrums portion of $ 2.0 million of the  5.9 million
milestone payment from Pharmion.



The first approval of satraplatin in
the United States and in Europe would trigger additional milestone payments of $9.0 million to Spectrum, as well as payments under certain compensation arrangements with our employees and members of our Supervisory Board as disclosed in footnote 12
to the accompanying consolidated financial statements, both of which have not been accrued due to the uncertainty of the regulatory approval process. Spectrum is also entitled to receive a share of sublicense fees and royalties, if any, received
from us under any marketing agreements for satraplatin that we enter into with other parties, such as those with Celgene and with Yakult.



There were no costs related to satraplatin in 2001 and/or prior years. Other project costs in 2001 and prior years cannot be presented in a meaningful manner on a
project basis because we did not have our project system fully implemented at all of our sites in these years.



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##### Table of Contents

As of December 31, 2007, we estimated that during 2008 we will incur approximately  5.2 million in costs, primarily related to patient follow up, for our on-going SPARC Phase 3 trial and other satraplatin-related trials; about  3.2 million related to cell cycle inhibitors, and about  1.2 related to other
projects. We are unable to reliably estimate the costs to complete our drug development projects, as well as anticipated completion dates, due to uncertainties associated with clinical trials. Therefore, any estimates to complete research and
development projects are highly speculative and may differ materially from actual expenses incurred for such projects. There are many factors outside our control that could delay or possibly prevent successful completion of our research and
development projects.



Furthermore, all estimates, including the estimate
provided in the previous paragraph, are forward looking, subjective and may be subject to change due to numerous risks and uncertainties associated with developing and commercializing biopharmaceutical products, including but not limited to
significant changes in government regulations, the uncertainty of future pre-clinical and clinical study results and uncertainties and the unpredictability associated with product development, regulatory approvals, manufacturing, and marketing.



2007 vs. 2006



Research and development expenses were  51.4 million for the year ended December 31, 2007, compared with  64.7 million for the year ended
December 31, 2006, a decrease of  13.3 million or 21%. Significant reductions were made to the research and development group during the second half of
2007, after the overall survival results of the SPARC trial were announced. Included in personnel expenses for 2007 above is  1.8 million of restructuring
costs. Also included in research and development expenses are satraplatin project costs of  20.8 million and  29.8 million for the years ended December 31, 2007 and 2006, respectively. The following table summarizes the changes in research and development expenses for the years ending
December 31, 2007 and 2006 (in millions of , except % change):



|                                                     |  |      |  |      |  |        |   |  |          |   
|---------------------------------------------------- |  | ---- |  | ---- |  | ------ | - |  | -------- | --
|                                                     |  | 2007 |  | 2006 |  | Change |   |  | % Change |   
|Personnel expense including stock-based compensation |  | 20.7 |  | 20.0 |  | 0.7    |   |  | 3.5      | % 
|Travel and entertainment                             |  | 1.0  |  | 1.1  |  | (0.1   | ) |  | (9.1     | )%
|Clinical trial costs                                 |  | 10.6 |  | 17.1 |  | (6.5   | ) |  | (38.0    | )%
|Raw materials and clinical supplies                  |  | 5.8  |  | 7.0  |  | (1.2   | ) |  | (17.1    | )%
|External research and development                    |  | 3.3  |  | 5.3  |  | (2.0   | ) |  | (37.7    | )%
|Consulting                                           |  | 2.5  |  | 1.7  |  | 0.8    |   |  | 47.1     | % 
|Licensing                                            |  | 1.3  |  | 5.3  |  | (4.0   | ) |  | (75.5    | )%
|Facilities and communications                        |  | 3.5  |  | 3.6  |  | (0.1   | ) |  | (2.8     | )%
|Depreciation                                         |  | 1.2  |  | 1.3  |  | (0.1   | ) |  | (7.7     | )%
|Other                                                |  | 1.5  |  | 2.3  |  | (0.8   | ) |  | (34.8    | )%
|                                                     |  |      | 
|Total research and development                       |  | 51.4 |  | 64.7 |  | (13.3  | ) |  | (20.6    | )%
|                                                     |  |      | 



Several research and development
expense categories decreased during 2007 as the SPARC trial neared completion. For example, clinical trial costs decreased  6.5 million or 38% in 2007
compared to 2006. These costs are expected to continue to decrease.



Raw
materials and clinical supplies expenses decreased  1.2 million or 17.1% in 2007 compared to 2006. This decrease is mainly due to the closure of the Waltham,
MA facility as well as decreased purchases of satraplatin in 2007 as the SPARC trial neared completion.



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##### Table of Contents

External research and development expenses decreased  2.0 million or 37.7% in 2007 compared to 2006. We conducted pre-clinical toxicology studies for the kinase inhibitor RGB-286638 during 2006 which are necessary prior to advancing a compound [[into the clinic]].



Consulting expenses increased  0.8 million or 47.1% in 2007 compared to 2006. This increase was due to the Company incurring certain fees during 2007 relating to the satraplatin NDA submission with the FDA.



Licensing decreased  4.0 million or 75.5% in 2007 compared to 2006. This decrease was due to the accrual of milestone payments that were deemed probable in 2006 and were paid to Spectrum in 2007, when the
NDA and MAA were accepted for filing. An additional milestone representing Spectrums share of the Pharmion milestone payment to us relating to the MAA acceptance was accrued and paid in 2007.



2006 vs. 2005



Research and development expenses were  64.7 million for the year ended December 31, 2006, compared with  55.7 million for the year ended December 31, 2005, an
increase of  9.0 million or 16.2%. Included in research and development expenses are satraplatin project costs of  29.8 million and  23.1 million for the years ended December 31, 2006 and 2005, respectively. The
following table summarizes the changes in research and development expenses for the years ending December 31, 2006 and 2005 (in millions of , except %
change):



|                                                     |  |      |  |      |  |        |   |  |          |   
|---------------------------------------------------- |  | ---- |  | ---- |  | ------ | - |  | -------- | --
|                                                     |  | 2006 |  | 2005 |  | Change |   |  | % Change |   
|Personnel expense including stock-based compensation |  | 20.0 |  | 18.4 |  | 1.6    |   |  | 8.7      | % 
|Travel and entertainment                             |  | 1.1  |  | 1.0  |  | 0.1    |   |  | 10.0     | % 
|Clinical trial costs                                 |  | 17.1 |  | 15.8 |  | 1.3    |   |  | 8.2      | % 
|Raw materials and clinical supplies                  |  | 7.0  |  | 3.3  |  | 3.7    |   |  | 112.1    | % 
|External research and development                    |  | 5.3  |  | 5.9  |  | (0.6   | ) |  | (10.2    | )%
|Consulting                                           |  | 1.7  |  | 1.3  |  | 0.4    |   |  | 30.8     | % 
|Licensing                                            |  | 5.3  |  | 1.2  |  | 4.1    |   |  | 341.7    | % 
|Facilities and communications                        |  | 3.6  |  | 3.9  |  | (0.3   | ) |  | (7.7     | )%
|Depreciation                                         |  | 1.3  |  | 3.3  |  | (2.0   | ) |  | (60.6    | )%
|Other                                                |  | 2.3  |  | 1.6  |  | 0.7    |   |  | 43.8     | % 
|                                                     |  |      |  |      |  |        |   |  |          |   
|Total research and development                       |  | 64.7 |  | 55.7 |  | 9.0    |   |  | 16.2     | % 
|                                                     |  |      |  |      |  |        |   |  |          |   



Personnel expense, including
stock-based compensation costs allocated to research and development, increased 8.7% or  1.6 million in 2006 compared to 2005. Additional R&D personnel
were hired in 2006 in response to increased work loads associated with the execution of clinical trials and the preparation and submission of parts of the rolling NDA for satraplatin.



Clinical trial costs increased  1.3 million
or 8.2%. This increase was due to the progression of the SPARC trial and includes clinical research organization expenses. We maintain contracts with clinical research organizations who conduct clinical trials for satraplatin.



Raw materials and clinical supplies expenses increased  3.7 million or 112.1%, in 2006 compared to 2005. This increase was due to the purchase of increased supplies of satraplatin related to the SPARC trial and other studies.



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Licensing expenses increased  4.1 or 341.7% in 2006 compared to 2005. This increase was due to the accrual of milestone payments that were deemed probable in 2006 and were paid to Spectrum in 2007, when the NDA and MAA were accepted for filing.



Depreciation expense decreased  2.0 million in 2006 compared to 2005. This decrease was primarily due to the acquisition of substantially all of the assets from Axxima Pharmaceuticals AG in the first quarter of 2005.
Many of the assets identified in the acquisition were laboratory leasehold improvements and were fully depreciated by the end of 2005 when the lease was terminated.



General and Administrative Expenses



General and administrative expenses consist primarily of compensation for employees in executive and operational functions, including finance, business development,
marketing, investor relations, legal, information technology, human resources, and sales. Other significant costs in this category include facilities costs and professional fees for accounting and legal services, travel, insurance premiums and
depreciation.



2007 vs. 2006



The following table summarizes the changes in general and administrative expenses for
the years ended December 31, 2007 and 2006 (in millions of , except % change):



|                                                     |  |      |  |      |  |        |   |  |          |   
|---------------------------------------------------- |  | ---- |  | ---- |  | ------ | - |  | -------- | --
|                                                     |  | 2007 |  | 2006 |  | Change |   |  | % Change |   
|Personnel expense including stock-based compensation |  | 19.3 |  | 12.5 |  | 6.8    |   |  | 54.4     | % 
|Travel and entertainment                             |  | 2.1  |  | 1.2  |  | 0.9    |   |  | 75.0     | % 
|IP and legal costs                                   |  | 6.8  |  | 0.9  |  | 5.9    |   |  | 655.6    | % 
|Commercialization                                    |  | 2.8  |  | 0.4  |  | 2.4    |   |  | 600.0    | % 
|Consulting                                           |  | 2.5  |  | 1.4  |  | 1.1    |   |  | 78.6     | % 
|Facilities and communications                        |  | 2.5  |  | 4.0  |  | (1.5   | ) |  | (37.5    | )%
|Depreciation                                         |  | 0.5  |  | 0.3  |  | 0.2    |   |  | 66.7     | % 
|Other                                                |  | 2.7  |  | 3.1  |  | (0.4   | ) |  | (12.9    | )%
|                                                     |  |      |  |      |  |        |   |  |          |   
|Total general and administrative expenses            |  | 39.2 |  | 23.8 |  | 15.4   |   |  | 64.7     | % 
|                                                     |  |      |  |      |  |        |   |  |          |   



General and administrative
salaries and personnel expense increased  6.8 million or 54.4% in 2007 compared to 2006. The increase in personnel expenses was primarily due to the
establishment of a sales and marketing infrastructure in the first half of 2007, in anticipation of the potential satraplatin product launch in the U.S. However, significant reductions were made to the sales and marketing group during the second
half of 2007, after the overall survival results of the SPARC trial were announced. Included in personnel expenses for 2007 above is  2.3 million of
restructuring costs. We expect personnel expense to decrease significantly as our restructuring plans announced in 2007 and the first quarter of 2008 are expected to be completed by December 31, 2008.



Travel and entertainment expenses increased  0.9 million or 75.0% in 2007 compared to 2006. This increase is primarily due to increased headcount year-over-year combined with an increase in employees attending various meetings and
conventions throughout 2007.



IP (Intellectual Property) and legal
expenses increased  5.9 million or 655.6% in 2007 compared to 2006 primarily due to expenses associated with the arbitration between us and Spectrum. As
disclosed in footnote 12 to the accompanying consolidated financial statements, we are not currently able to estimate the possible cost from the shareholder litigation.



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Commercialization expenses increased  2.4 million or 600.0% in 2007 compared to 2006. This increase was primarily due to medical education costs relating to the potential satraplatin product launch in the U.S. We expect these costs to decrease in 2008 due to cost
cutting measures implemented in 2007 and the first half of 2008.



Consulting expenses increased  1.1 million or 78.6% in 2007 compared to 2006. This increase was primarily due to the increase in projects relating to
the anticipated approval of satraplatin in the U.S. We expect these costs to decrease significantly in 2008.



Facilities and communications expenses decreased  1.5 million or 37.5% in
2007 compared to 2006. This decrease was primarily related to the closure of our Waltham, MA facility. We expect these costs to continue to decrease in 2008 due to the cost cutting measures implemented in 2007 and the first half of 2008.



2006 vs. 2005



The following table summarizes the changes in general and administrative expenses for the years ended December 31, 2006 and 2005
(in millions of , except % change):



|                                                     |  |      |  |      |  |        |   |  |          |   
|---------------------------------------------------- |  | ---- |  | ---- |  | ------ | - |  | -------- | --
|                                                     |  | 2006 |  | 2005 |  | Change |   |  | % Change |   
|Personnel expense including stock-based compensation |  | 12.5 |  | 10.5 |  | 2.0    |   |  | 19.0     | % 
|Travel and entertainment                             |  | 1.2  |  | 0.8  |  | 0.4    |   |  | 50.0     | % 
|IP and legal costs                                   |  | 0.9  |  | 0.7  |  | 0.2    |   |  | 28.6     | % 
|Commercialization                                    |  | 0.4  |  | 0.6  |  | (0.2   | ) |  | (33.3    | )%
|Consulting                                           |  | 1.4  |  | 0.4  |  | 1.0    |   |  | 250.0    | % 
|Facilities and communications                        |  | 4.0  |  | 4.4  |  | (0.4   | ) |  | (9.1     | )%
|Depreciation                                         |  | 0.3  |  | 0.3  |  |       |   |  |         |   
|Other                                                |  | 3.1  |  | 2.9  |  | 0.2    |   |  | 6.9      | % 
|                                                     |  |      |  |      |  |        |   |  |          |   
|Total general and administrative expenses            |  | 23.8 |  | 20.6 |  | 3.2    |   |  | 15.5     | % 
|                                                     |  |      |  |      |  |        |   |  |          |   



General and administrative
personnel expense increased  2.0 million or 19.0% in 2006 compared to 2005. The increase in personnel expenses was primarily due to the hiring of certain
senior level positions in marketing, sales and drug development during 2006.



Consulting expense increased  1.0 million or 250% to 
1.4 million in 2006 compared to 2005. This increase resulted mainly from increases in recruiting costs and consulting fees as we began to increase staff in key areas, including marketing and sales during 2006.



Long Term Liabilities



In June 2007, we entered into a license agreement with Yakult for development and commercialization of satraplatin in Japan. The
non-refundable upfront license payment of  7.4 million was included in deferred revenue, non-current, as of December 31, 2007, as the Company was not
able to estimate the period of substantial involvement. The Company will continue to defer the revenue until the timing of the satraplatin development plan, which approximates the period of substantial involvement, can be reliably determined. The
increase of non-current portion of deferred revenue in 2007 was offset with the amortization of Pharmion-related deferred payments received under the co-development and license agreement. As a result, non-current portion of deferred revenue
increased by  4.9 million or 53.7% to  14.0 million as of
December 31, 2007.



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In May of 2005, we established an accrual for loss on sub-lease contract at the Waltham, MA facility. In 2007, we
reached an agreement with the landlord to terminate the lease and vacated this space effective December 31, 2007, at which point the accrual was then reclassed to other current liabilities. This remaining liability represents contract
termination costs that will be paid over the first nine months of 2008 as of December 31, 2007. Please refer to footnotes 10 and 11 to the accompanying consolidated financial statements.



Stock-based Compensation



Stock Options and Convertible Bonds



Prior to January 1, 2006, we accounted for stock-based compensation under
Statement of Financial Accounting Standards No. 123, Accounting for Stock-Based Compensation, (SFAS 123). Effective January 1, 2006, we adopted Statement of Financial Accounting Standards No. 123 (revised 2004),
Share-Based Payment, (SFAS 123(R)), which requires all share-based payments to employees to be recognized in the financial statements based on their fair values. All of the Companys share compensation plans impose on
the beneficiary a holding period, a four-year vesting schedule and certain market-related performance hurdles, all of which have to be met prior to exercising any options. Under SFAS 123(R), a company whose share based compensation plans feature
both a service and a market condition is required to use a requisite service period for recognizing stock based compensation over time. This requisite service period is determined by identifying the longer of an estimated derived service
period and the explicit service period (the contractual vesting period). The derived service period is an estimated period that assesses when a beneficiary would actually exercise the instrument, using a Monte Carlo simulation.



The detailed calculations and requirements of SFAS 123(R) are complex.
In the fourth quarter of 2007, we determined that based on SFAS 123(R), we were not able to use the explicit service period but that we were required to use the longer derived service period to amortize the fair value of the awards. Based on this
determination, we were required to adjust previously reported quarterly share-based compensation expense to reduce the amounts previously charged to expense. Please refer to footnote 2 to the accompanying consolidated financial statements for
further details. The related fair value of the awards was properly recognized over the derived service period in the annual consolidated financial statements for 2007. Share-based compensation expense is a non-cash item and this expense adjustment
had no net impact on our equity. Please refer to Item 15 for the impact of the adjustment on the internal control assessment.



The following table summarizes the allocation of stock-based compensation expense in the statement of operations during 2007, 2006 and 2005 (in million ):



|                                       |  |      |  |      |  |     
|-------------------------------------- |  | ---- |  | ---- |  | ----
|                                       |  | 2007 |  | 2006 |  | 2005
|Research and development expense       |  | 1.4  |  | 2.9  |  | 3.3 
|General and administrative expense     |  | 2.1  |  | 4.0  |  | 3.4 
|                                       |  |      |  |      |  |     
|Total stock-based compensation expense |  | 3.5  |  | 6.9  |  | 6.7 
|                                       |  |      |  |      |  |     



The fair value of stock-based
compensation is amortized to expense using the derived service period. The decrease in stock-based compensation expense in 2007 is due to the reversal of previously recognized cost related to unvested shares that were forfeited during the year. As
of December 31, 2007, there was  2,866,000 and  15,586,000 of total
unrecognized compensation cost related to unvested share-based compensation arrangements granted under the plans for stock options and convertible bonds respectively. The weighted average period over which the compensation cost for stock options and
convertible bonds will be recognized is approximately 57 and 59 months respectively.



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Stock Appreciation Rights



Since 2004, we have issued stock appreciation rights, or SARs, to members of the Supervisory Board and to certain members of the
senior management team. These SARs vest upon certain performance trigger events such as (but not limited to) the marketing approval of satraplatin in the United States or the European Union (or both) and will be settled in cash. Therefore, SARs are
accounted for as liability awards under SFAS 123(R).



Compensation
expense for SARs, if any, will be accrued and recognized based on the fair value at each balance sheet date. Compensation expense recorded will be equal to the amount of cash ultimately paid to settle the SARs. At December 31, 2007 and 2006, we
deemed the dosing of the first patient in a second registrational trial for satraplatin probable. Therefore, 151,000 was recognized as compensation expense for
128,750 SARs relating to this performance condition in 2006. In the same period, an additional  18,000 was recognized for SARs without performance conditions which
were already fully vested. The majority of the cost was charged to research and development expense. However, in 2007 the fair value of the underlying shares experienced a significant decrease, which required us to reverse all but  33,000 of the amount recorded in the prior year.



As of December 31, 2007, there was  273,000 of total unrecognized
compensation cost related to unvested, non-probable, SARs granted. That cost was not yet recognized since the vesting of the underlying liability instruments was not deemed probable at December 31, 2007.



Other Income (Expense), net



A significant portion of other income and expense relates to foreign currency gains and
losses on accounts receivable, accounts payable and cash. In 2007 and 2006, the U.S. dollar weakened against the euro, thus resulting in foreign currency gains (losses) of  0.2 and (2.1) million, respectively.



Liquidity and Capital
Resources



Our cash, cash equivalents, marketable securities and
short-term investments totaled  63.8 million, and our restricted cash totaled  1.4 million, at December 31, 2007. We invest our cash in investments that have relatively short maturities and that are placed with highly rated issuers. Marketable securities and short-term investments include bonds from
corporate issuers. As a general policy, we do not invest in equity securities for cash management purposes. Any equity securities we own were acquired as part of licensing agreements in prior years. As of December 31, 2007, our marketable
securities and short-term investments amounted to  14.1 million and mostly consisted of variable- and fixed-rate corporate bonds which were sold at cost upon
maturity, subsequent to year-end.



We have historically financed our
operations primarily through the issuance of equity securities, cash payments (including licensing fees) from several collaboration partners, interest earned on investments, government grants, and convertible bonds.



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The following table summarizes our sources of funding over the last five years (in thousands of ):



|     |  |                                          |  |                                                                 |  |                            |  |                              |  |                             |  |       
|---- |  | ---------------------------------------- |  | --------------------------------------------------------------- |  | -------------------------- |  | ---------------------------- |  | --------------------------- |  | ------
|Year |  | From the issuance ofequitysecurities,net |  | From cashpaymentsfromcollaborationpartners
andlicenseagreements |  | From interestoninvestments |  | Fromconvertiblebondissuances |  | Othersources offinancing(1) |  | Total 
|2007 |  | 39,894                                   |  | 18,787                                                          |  | 1,926                      |  | 521                          |  | 212                         |  | 61,340
|2006 |  | 40,623                                   |  | 34,816                                                          |  | 4,446                      |  | 970                          |  | 1,661                       |  | 82,516
|2005 |  | 10,929                                   |  | 7,501                                                           |  | 3,558                      |  | 580                          |  |                            |  | 22,568
|2004 |  | 80,014                                   |  | 9,348                                                           |  | 1,966                      |  | 935                          |  |                            |  | 92,263
|2003 |  | 292                                      |  | 16,383                                                          |  | 3,276                      |  | 517                          |  | 807                         |  | 21,275



|(1) | Other sources of financing include mostly funds received from governmental grants and others.
|--- | ---------------------------------------------------------------------------------------------



Capital resources from collaboration partners declined in 2004 and further in 2005 as
our work on technology platform collaborations decreased. We increased our focus during this time on drug development and focused less on entering into new technology collaborations. During 2006, resources from collaboration partners increased
significantly as a result of the upfront development-related payments we received from Pharmion for the co-development and license agreement for satraplatin in Europe. Capital resources from collaboration partners declined in 2007 compared to 2006,
although this was partially offset by an upfront payment as reimbursement for past development expenses related to satraplatin that we received from Yakult. We expect monies from current collaboration partners to decline in 2008. However, if
satraplatin were to receive marketing approval in Europe in 2008, monies would increase, as we would then receive a net milestone payment from Celgene in the amount of  11.3 million. We cannot predict if we will receive marketing approval for satraplatin in Europe in 2008 or at all See Item 3D Risk FactorsSatraplatin may never receive regulatory approval in the United States or Europe and
may never be successfully commercialized and you may lose all or a substantial part of your investment.



A large portion of the capital resources used to fund operations has been derived from the issuance of shares in various significant equity transactions, as well as
upon exercise of stock options and convertible bonds. As of December 31, 2007, our shareholders have authorized the future issuance of 33,546,297 ordinary shares for specific purposes.



In January 2007, we sold 1.56 million newly issued ordinary shares in a private
placement with net proceeds of  32.6 million.



In February 2006, we sold 2.9 million newly issued ordinary shares in a private placement with net proceeds of  36.1 million.



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The following table summarizes selected information from our consolidated statements of cash flows and balance
sheets for 2007, 2006 and 2005 (in million ):



|                                                                               |  |       |   |  |       |   |  |       |  
|------------------------------------------------------------------------------ |  | ----- | - |  | ----- | - |  | ----- | -
|Selected Cash Flow Information                                                 |  | 2007  |   |  | 2006  |   |  | 2005  |  
|Operating activities                                                           |  |       |   |  |       |   |  |       |  
|Net Loss                                                                       |  | (69.2 | ) |  | (64.0 | ) |  | (62.2 | )
|Adjustments to net loss, including changes in working capital                  |  | 2.5   |   |  | 27.4  |   |  | 19.4  |  
|                                                                               |  |       |   |  |       |   |  |       |  
|Net cash used in operating activities                                          |  | (66.7 | ) |  | (36.6 | ) |  | (42.8 | )
|Investing activities                                                           |  |       |   |  |       |   |  |       |  
|Purchases of property, equipment and licenses                                  |  | (1.6  | ) |  | (1.9  | ) |  | (4.5  | )
|Proceeds from sale of property and equipment                                   |  | 0.1   |   |  |      |   |  | 0.2   |  
|Net proceeds marketable securities and short-term investments                  |  | 42.3  |   |  | 5.6   |   |  | 4.3   |  
|                                                                               |  |       |   |  |       |   |  |       |  
|Net cash provided by investing activities                                      |  | 40.8  |   |  | 3.7   |   |  |      |  
|Financing activities                                                           |  |       |   |  |       |   |  |       |  
|Proceeds from shares issued upon:                                              |  |       |   |  |       |   |  |       |  
|Asset acquisition                                                              |  |      |   |  |      |   |  | 10.4  |  
|Equity offering                                                                |  | 32.6  |   |  | 36.1  |   |  |      |  
|Exercises of stock-based compensation                                          |  | 7.3   |   |  | 4.2   |   |  | 0.5   |  
|Subscribed shares                                                              |  |      |   |  | 0.3   |   |  |      |  
|Other financing activities                                                     |  | 0.5   |   |  | 1.0   |   |  | 0.6   |  
|                                                                               |  |       |   |  |       |   |  |       |  
|Net cash provided by financing activities                                      |  | 40.4  |   |  | 41.6  |   |  | 11.5  |  
|Net increase (decrease) in cash                                                |  | 11.3  |   |  | 7.8   |   |  | (28.9 | )
|Cash and cash equivalents at end of year                                       |  | 49.7  |   |  | 38.3  |   |  | 30.6  |  
|Marketable securities and short-term investments at end of year                |  | 14.1  |   |  | 57.2  |   |  | 63.1  |  
|                                                                               |  |       |   |  |       |   |  |       |  
|Total cash, cash equivalents, marketable securities and short-term investments |  | 63.8  |   |  | 95.5  |   |  | 93.7  |  
|                                                                               |  |       |   |  |       |   |  |       |  



The increase of cash used in
operating activities is primarily attributable to the timing of the payment received from Pharmion during 2006, as well as a decrease of revenues described in details above.



During the year 2007, net proceeds from the sale of marketable securities and short-term investments were  42 million. The net proceeds were placed in money market funds for higher return on investments.



As of December 31, 2007, we believe our cash, cash equivalents, marketable securities, short-term investments on hand, anticipated interest earned on our
investments, and future payments we expect to receive from our co-development and license agreement with Celgene and others, to be sufficient to fund currently planned business operations until approximately the end of 2010. If, at anytime, our
ability to internally finance our research programs changes, we may decide to reduce research and development expenses by delaying, discontinuing or reducing our funding of development of one or more product candidates. Alternatively, we might raise
funds through public or private financings, collaborations or other arrangements. There can be no assurance that the funding, if needed, will be available on attractive terms, or at all. Furthermore, any additional equity financing may be dilutive
to stockholders, and debt financing, if available, may involve restrictive covenants. Similarly, financing obtained through future co-development or co-marketing arrangements may require us to forego certain commercial rights to, and revenues from,
current or potential product candidates. Our failure to raise capital, if and when needed, could have a negative impact on our business, financial condition, operating results, and ability to pursue our business strategy.



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Contractual Obligations



Set forth below is a description of our contractual obligations as of December 31, 2007 (in thousand ):



|                           |  |                        |  |                |  |            |  |            |  |                
|-------------------------- |  | ---------------------- |  | -------------- |  | ---------- |  | ---------- |  | ---------------
|                           |  | Payments due by period
|Contractual Obligations    |  | Total                  |  | Lessthan 1year |  | 1  3years |  | 3  5years |  | Morethan 5years
|Operating leases           |  | 1,725                  |  | 1,092          |  | 633        |  |           |  |               
|Convertible bonds          |  | 3,365                  |  | 174            |  |           |  |           |  | 3,191          
|Contract termination costs |  | 2,094                  |  | 2,094          |  |           |  |           |  |               
|                           |  |                        |  |                |  |            |  |            |  |                
|Total                      |  | 7,184                  |  | 3,360          |  | 633        |  |           |  | 3,191          
|                           |  |                        |  |                |  |            |  |            |  |                



Our long-term commitments under
operating leases shown above consist of payments relating to our facility lease in Munich, Germany and Princeton New Jersey, USA. Contract termination costs relate the facility located in Waltham, Massachusetts, USA.



The contractual obligations table does not include amounts for milestone payments. We
have entered, and from time to time we may enter, into agreements under which we are or may be obligated to make payments which are contingent upon the occurrence of certain events. As of December 31, 2007, the total maximum amount of milestone
payments we may be obligated to make under these agreements was approximately  40.2 million. However, this amount includes obligations related to pre-clinical and
earlier stage projects, as well as projects that may be discontinued and, therefore, it is unlikely that all of these milestones will be achieved. In 2005 and 2007, we made actual payments of approximately  0.4 million and  5.2 million, respectively, under these agreements, all of which were in
connection with milestones relating to regulatory filings. We made no such payments in 2006.



The actual amounts and the timing of these contingent payments depend on numerous factors, some of which are outside of our control. Some factors include the success of our preclinical and clinical development efforts with
respect to the products being developed under these agreements, the substance and timing of determinations of the U.S. Food and Drug Administration, the United States Patent and Trademark Office and other regulatory authorities, and the volume of
sales or gross margin of a product in a specified territory, as well as certain other factors. These events are subject to numerous risks and uncertainties, including those discussed under Risk Factors in Item 3 and, therefore we
cannot accurately predict the timing, probability and amounts of these payments. Accordingly, costs related to these payments are only reflected in our consolidated financial statements when the achievement of the underlying milestone is deemed
probable.



Off-Balance Sheet Transactions



We have not had any relationships with unconsolidated entities or financial
partnerships, such as entities often referred to as structured finance or special purpose entities, which would have been established for the purpose of facilitating off-balance sheet arrangements or other contractually narrow or limited purposes.
In addition, we are not engaged in trading activities involving non-exchange traded contracts. Therefore, we are not materially exposed to any financing, liquidity, market or credit risk that could arise if we had been engaged in these
relationships.



German Tax Treatment of Loss Carry-Forwards



We have significant tax loss carry-forwards. Please refer to footnote 16 in our
consolidated financial statements included in this annual report for a detailed description of income taxes. Under



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current German tax law, a corporation is generally permitted to set-off loss carry-forwards (Verlustvorträge) against annual taxable income up to  1.0 million. The remaining loss carry-forwards can be set-off against up to 60% of the taxable income of the individual tax assessment period exceeding  1.0 million.



The use of such loss carry-forwards is, however, subject to special limitations which were amended by the Tax Reform Act 2008 (Unternehmenssteuerreform 2008). The new limitation provision (Sec. 8c German Corporate Income
Tax Act (Körperschaftsteuergesetz, KStG) applies from January 1, 2008, onwards and with respect to relevant transfers after December 31, 2007. The previous limitation provision (Sec. 8 para 4 KStG) is still
applicable if (i) more than 50% of the shares in a corporation are transferred within a time period of five years beginning before January 1, 2008, and (ii) the loss of the economic identity occurs before January 1, 2013.
Accordingly, both regimes are described below:



Sec 8 para 4 KStG
(previous law):Pursuant to Sec 8 para 4 KStG any set-off against loss carry-forwards requires that the offsetting entity is economically identical to the loss-incurring entity. The offsetting entity is, in
particular, not economically identical to the loss-incurring entity if



| |  | more than 50 % (in aggregate) of the shares in a corporation are transferred within five years, which, according to the German tax authorities, includes the subscription of new shares
issued in the course of a capital increase to new shareholders, and
| | - | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  | predominantly new business assets are injected into such corporation.
| | - | ---------------------------------------------------------------------



In this case, any loss carry-forwards existing at the time of the fulfillment of these two conditions are no longer be available for set-off against any of the
corporations current and future taxable income. This applies to corporate income tax as well as to trade tax.



Sec 8c KStG (current law):Pursuant to Sec. 8c KStG, in particular the transfer of more than 25% of the shares or voting rights in a
corporation to one purchaser or related parties or to a group of purchasers with similar interests (gleichgerichteten Interessen) within a period of five years results in a partial loss of existing tax loss carry-forwards (including, but not limited
to an interest carry forward) and annual losses suffered prior to the detrimental transfer. Such detrimental transfer of more than 25% (but not 50% or more) of the shares or voting rights leads to a pro-rata diminution of the existing loss carry
forwards and of annual losses suffered prior to the detrimental transfer. The use of such loss carry-forwards and annual losses suffered prior to the detrimental transfer is inter alia denied entirely in the event that more than 50% of the
shares or voting rights are transferred within five years. This applies to corporate income tax as well as to trade tax.



As of December 31, 2007, the statue of limitations for income tax audits in Germany remains open for the tax years ended on or after December 31, 2004.



At December 31, 2007, 2006, and 2005, we had deferred tax assets
representing the benefit of accumulated tax net operating loss carry-forwards. We have provided a full valuation allowance on our deferred tax assets because we believe it is more likely than not that our deferred tax assets will not be realized.



Critical Accounting Policies



The discussion and analysis of our financial condition and results of operations are
based on our consolidated financial statements, which have been prepared in accordance with U.S. GAAP. The preparation of these financial statements requires us to make estimates and judgments that affect the reported amounts of assets, liabilities
and expenses and related disclosure of contingent assets and



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liabilities. We review our estimates on an ongoing basis. We base our estimates on historical experience and on various other assumptions that we believe to be
reasonable under the circumstances. Actual results may differ from these estimates under different assumptions or conditions. While our significant accounting policies are described in more detail in the notes to our consolidated financial
statements included elsewhere in this annual report, we believe the following accounting policies to be critical to the judgments and estimates used in the preparation of our consolidated financial statements.



Revenue Recognition



Our revenues consist of fees earned from co-development and licensing arrangements,
research and development collaboration agreements, and grant revenues. Revenues from co-development and licensing agreements and from research and development collaborations agreements generally consist of licensing fees and/or technology access
fees, reimbursement fees, payments from a partner for shared development costs, fees for research and development support, as well as milestone and royalty payments. Revenues from grants generally consist of reimbursements of a portion of expenses
incurred in performing research in specified projects.



We recognize
revenue in accordance with SEC Staff Accounting Bulletin No. 104, Revenue Recognition, (SAB 104), Emerging Issues Task Force Issue No. 00-21, Revenue Arrangements with Multiple Deliverables, (EITF 00-21)
and EITF Issue No. 99-19, Reporting Revenue Gross as a Principal Versus Net as an Agent, (EITF 99-19). In accordance with SAB 104, we recognize revenue when there is persuasive evidence that an arrangement exists, the fee is
fixed or determinable, and collection of the related receivable is probable. The terms of GPC Biotechs revenue arrangements may contain multiple elements which can include non-refundable upfront payments such as reimbursement fees or license
fees, payments based upon certain milestones, payments to co-fund the development of a product and royalties on product sales. We evaluate these arrangements to determine if the deliverables are separate units of accounting in accordance with EITF
00-21, allocate total consideration based on the relevant method and then apply the appropriate revenue recognition criteria for each unit of accounting. We also evaluate the arrangement to determine if revenue should be recognized at gross or net
in accordance with EITF 99-19.



Applying SAB 104, EITF 00-21 and EITF
99-19 requires significant management judgments and facts and circumstances can change as the research and development activities proceed. Circumstances and conditions can change and may cause the amount of revenue recognized in future period to
increase or decrease.



Licensing Arrangements



We generally receive non-refundable upfront fees upon signing of a licensing agreement.
These fees generally include licensing fees, technology access fees and initiation fees. All non-refundable upfront fees received or to be received under these arrangements are recognized when SAB 104 revenue recognition criteria are met, ratably
over the period over which the license is granted or we are substantially and continually involved, which in many cases coincides with the term of the agreement or the license period or other appropriate period when this period can be reliably
estimated.



Co-Development Arrangements



Revenue recognized from partners in co-development arrangements is generally based on a
fixed percentage of agreed upon research, development and commercialization costs incurred by the Company. Revenue from these co-development arrangements are recognized on a gross basis as



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collaboration revenue in the consolidated statement of operations as the related costs are incurred. If payments are received prior to the activity having been
performed, these amounts are deferred and recognized in future periods when the co-development costs are incurred.



Milestone Payments



Milestone payments are recognized as revenue when the performance obligations, as defined in the contracts, are achieved. Performance obligations typically consist
of significant milestones in the life cycle of the related technology or product candidate, such as initiation of clinical trials, filing for approval with regulatory agencies and approvals by regulatory agencies. These milestone payments are
generally tied to a specific performance condition and are recognized in full when the performance obligation is met. The reaching of a milestone is evidenced by a milestone confirmation letter that is signed and dated by both parties. In the
absence of such milestone confirmation, no milestone revenue is recognized, unless there is other persuasive evidence that the milestone event has been reached and the milestone fee has been earned.



Grant Revenues



Grant revenues from governmental agencies for the support of specific research and development projects are recorded as revenue to the
extent the related expenses have been incurred and billed in accordance with the terms of the grant.



Research and Development



Research and development (R&D) expenses include salaries, benefits, and other headcount related costs; clinical trial and related clinical manufacturing costs;
contract and other outside service fees; employee stock-based compensation expense; and facilities and overhead costs. R&D expenses consist of independent R&D costs and costs associated with collaborative R&D and in-licensing
arrangements. In addition, we acquire R&D services from other companies and fund research institutions under agreements which we can generally terminate at will. R&D costs, including upfront fees and milestones paid to collaborators, are
expensed as incurred, if the underlying assets are determined to have no alternative future use.



Accrued Expenses



As part of the process of preparing our financial statements, we are required to estimate certain expenses as of each balance sheet date and make appropriate
accruals based on these estimates. Our accrued expenses include:



| |  |  | contract service fees, such as amounts due to contract research organizations;
| | - |  | ------------------------------------------------------------------------------



| |  |  | professional service fees, such as amounts due to attorneys, accountants and investigators in conjunction with preclinical and clinical trials, and other activities;
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | fees paid to contract manufacturers in conjunction with the production of materials related to our product candidates;
| | - |  | ----------------------------------------------------------------------------------------------------------------------



| |  |  | development milestone accruals and other accruals.
| | - |  | --------------------------------------------------



In connection with these accruals, our estimates are affected by our understanding of the status and timing of services provided relative to the actual level of
services performed by the service providers. In the event that we under-or over-estimate the level of services or the costs of such services, our reported expenses for a reporting period could be overstated or understated. The date on which certain
services commence, the level of services performed on or before a given date, and the



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cost of services are often subject to our judgment. We make these judgments based upon the facts and circumstances known to us at the date of the financial statements.
For the periods presented in our consolidated financial statements, we have made no material adjustments to our estimates of contract research and development and professional services fees.



In connection with our research and development programs, we may incur milestone
payments to other parties. In accordance with Statement of Financial Accounting Standards No. 5, Accounting for Contingencies, (SFAS 5), we expense milestone payments when we incur the liability, which is when the milestones
are deemed probable.



Stock-Based Compensation



We grant stock options to our Management Board, senior management, and to employees.
Under the terms of our stock option plans, options are exercisable within ten years of the date of grant, subject to an initial two-year waiting period as required by German law. The exercise price equals the average of the market price of our
ordinary bearer shares over a five-day period prior to the date of grant.



Prior to January 1, 2006, we accounted for stock-based compensation under SFAS 123, however, effective January 1, 2006, we adopted SFAS 123(R) which requires all share-based payments to employees to be recognized in the
financial statements based on their fair values. SFAS 123(R) requires that we apply a forfeiture rate to existing awards and apply the standards fair value recognition provisions. The fair value of stock options is estimated on the date
of grant using the Monte Carlo valuation model for options granted from January 1, 2006. The Company recognizes compensation expense over the employee requisite service period which is the longer of the explicit service period stipulated in the
contract or the derived service period. The derived service period is inferred from valuation techniques used by the Company to estimate fair value. Awards are considered vested when the requisite service period has been rendered.



We also grant convertible bonds to Management Board, senior management, and certain
employees. In the past, we have also granted convertible bonds to our Supervisory Board. The fair value of our convertible bonds is calculated using the same assumptions as those used for our stock options, and is recognized as compensation expense
over the employee requisite service period.



Significant assumptions used
in determining the fair value of the awards are disclosed in footnote 15 to the accompanying consolidated financial statements. We estimate the fair value of our stock options and convertible bonds using multiple variables, including share price
volatility, risk-free interest rate, future dividends to be paid by us, the life of the option or convertible bond and the expected forfeiture rate. We estimate share price volatility based on actual historical share prices over the estimated life
of the option starting with the grant date for all options and convertible bonds issued during the year. The risk-free interest rate used in the calculation is the interest on debt issued by the German government with a maturity similar to the
estimated life of the stock options or convertible bonds. We estimate that we will not pay dividends in the foreseeable future. Any changes in estimates of volatility, risk-free interest rate, future dividends, the life of the options and
convertible bonds and forfeitures would result in increases or decreases in the amount of compensation expense recognized in any given period.



We also grant stock-based compensation with performance conditions in the form of SARs and convertible bonds. The vesting on SARs is contingent upon various
performance conditions relating to satraplatin and will be settled in cash. As such, they are accounted for as liability instruments. Compensation expense for SARs, if any, will be accrued and recognized based on the fair value at each balance sheet
date estimated using the Black-Scholes valuation model. Compensation expense



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will be recorded when the performance conditions are probable and will be equal to the amount of cash ultimately paid to settle the SARs. In 2006, we recognized
approximately  0.2 million as compensation expense for certain SARs which performance conditions were deemed to be probable. However, the fair value of the
underlying shares experienced a significant decrease in 2007 which required us to significantly reduce the liability.



Impairment of Long-Lived Assets



In accordance with Statement of Financial Accounting Standards No. 144, Accounting for the Impairment or Disposal of Long-Lived Assets, (SFAS
144), we review long-lived assets for impairment when impairment indicators exist and, if necessary, recognize an impairment charge equal to the difference between the carrying amount of the asset and the fair value which is estimated based on
either appraised value or measured by discounted estimated future cash flows.



Indicators that result in reviewing our long-lived assets for impairment are, among others, termination of research programs, restructuring programs, equipment obsolescence, idle equipment, or vacating of facilities. The Company recognized
an impairment charge of approximately  0.9 million in 2007 which represented the difference between the fair value of the assets no longer in use and
available for sale, and their net carrying value. These fixed assets are no longer in use as a result of the restructurings at the Waltham, Princeton and Munich facilities. No impairment expense was recognized for the years ended December 31,
2006 or 2005.



Income Tax



We provide for income taxes in accordance with Statement of Financial Accounting
Standards No. 109, Accounting for Income Taxes, (SFAS 109). SFAS 109 requires the use of the asset and liability method of accounting for deferred income taxes. Under this method, deferred tax assets and liabilities are
determined based on differences between financial reporting and tax bases of assets and liabilities and are measured using the enacted tax rates and laws that will be in effect when the differences are expected to reverse. Deferred tax assets are
reduced by a valuation allowance to reflect the uncertainty associated with their ultimate realization.



As of January 1, 2007, we adopted FASB Interpretation No. 48, Accounting for Uncertainty in Income Taxes an interpretation of FASB Statement
No. 109, (FIN 48). FIN 48 creates a single model to address accounting for uncertainty in tax positions taken or expected to be taken in a tax return. Under FIN 48, the tax benefit from an uncertain tax position may be
recognized only if it is more likely than not that the tax position will be sustained, based solely on its technical merits. We have certain deferred tax assets as a result of several years of losses from operations and currently have a full
valuation allowance for those deferred tax assets and have not recognized any benefits from uncertain tax positions in earnings. Accordingly, the adoption of the provisions of FIN 48 did not have material impact on our financial statements.



Recent Accounting Pronouncements



In footnote 3 of the consolidated financial statements, we disclose other new
accounting standards, however we do not consider them to have a material impact on our financial statements upon adoption.



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Item 6. Directors, Senior Management and Employees



Overview



In accordance with the German Stock Corporation Act (Aktiengesetz), we have two separate boards of directors. These are the
Vorstand, or Management Board, and the Aufsichtsrat, or Supervisory Board. The two boards are separate, and generally no individual may simultaneously be a member of both boards. For a more detailed description of the relative powers,
responsibilities and practices of the Management Board and the Supervisory Board as well as other material information about our governance, please refer to Item 10 Additional InformationGovernance.



Supervisory Board



The following table shows the current members of the Supervisory Board, the years in which they were first elected, the end of their current terms
and their principal occupations.



|                                     |  |     |  |                   |  |               |  |                                                                                                
|------------------------------------ |  | --- |  | ----------------- |  | ------------- |  | -----------------------------------------------------------------------------------------------
|Name                                 |  | Age |  | Year firstelected |  | End ofterm(1) |  | Principal occupation                                                                           
|Jürgen Drews, M.D. (Chairman)        |  | 73  |  | 1998              |  | 2009          |  | n/a                                                                                            
|Michael Lytton, J.D. (Vice Chairman) |  | 50  |  | 2001              |  | 2007          |  | General partner of Oxford Bioscience Partners                                                  
|Metin Colpan, Ph.D.                  |  | 51  |  | 1998              |  | 2009          |  | Founder and member of the supervisory board of Qiagen N.V.                                     
|Don Soltysiak                        |  | 63  |  | 2007              |  | 2009          |  | Consultant                                                                                     
|Peter Preuss                         |  | 63  |  | 2001              |  | 2007          |  | President of Preuss Foundation for Brain Tumor Research; Regent of the University of California
|James M. Frates                      |  | 40  |  | 2004              |  | 2007          |  | Chief Financial Officer, Senior Vice President and Treasurer of Alkermes, Inc.                 



|(1) | Term ends upon the end of the annual general meeting passing a resolution on discharge from liability for actions during the
fiscal year indicated.
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------



The members of our Supervisory
Board may be contacted at the German address of GPC Biotech. The Supervisory Board has determined that, with the exception of Mr. Soltysiak, who has an existing consulting arrangement with the Company (described under Item 7 Major
Shareholders and Related Party TransactionsRelated Party Transactions below) all of its current members are independent pursuant to the criteria contained in Nasdaq Marketplace Rules.



Jürgen Drews.    Chairman of the Supervisory
Board since 2001. Dr. Drews was a Managing Partner at Bear Stearns Health Innoventures until September 2004. Previously, he was the President of Global Research at Hoffmann-La Roche and a former member of the Board of Directors and a Partner of
BIOMEDICINE, International Biomedicine Management Partners. He previously served as the Chairman of EuropaBio, the European Association for Bioindustries, which has more than 500 individual member companies. Dr. Drews was Chairman of the Board
of Genaissance Pharmaceuticals, New Haven, CT until October 2005 and served on the boards of several biotech companies worldwide. Currently he is a board member at Human Genome Sciences, Rockville, MD and MorphoSys AG, Munich, Germany.



Michael Lytton.    Vice Chairman of the
Supervisory Board since January 2004. Mr. Lytton has been a General Partner at Oxford Bioscience Partners since January 2001. Previously, he was Partner, Chairman of the Technology Group and member of the Executive Committee of
Palmer & Dodge LLP. In this capacity, he advised GPC Biotech for several years. Mr. Lytton is a graduate of



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Princeton University and recipient of a Fulbright Scholarship for study at the University of London. He received an M.Sc. in Epidemiology and Medical Statistics from
the London School of Hygiene and Tropical Medicine and his J.D. from Harvard Law School. Mr. Lytton also serves on the boards of several companies worldwide, including Acambis, Cambridge, UK, (until summer 2006); Alantos Pharmaceuticals,
Cambridge, MA, Santhera Pharmaceuticals, Basel, Switzerland, Rib-X Pharmaceuticals, New Haven, CT, VaxInnate Corporation, Cranbury, NJ, Enanta Pharmaceuticals, Watertown, MA, Decision Biomarkers, Waltham, MA, Claros Diagnostics, Woburn, MA and,
Radius Health, Cambridge, MA.



Metin
Colpan.    Dr. Colpan is co-founder of Qiagen N.V. and served as Qiagen N.V.s Chief Executive Officer and President from 1985 through 2003. Qiagen N.V. has been listed on Nasdaq since 1996 and on the Frankfurt
Stock Exchange since 1997. He obtained his Ph.D. and M.Sc. in Organic Chemistry and Chemical Engineering from the Darmstadt Institute of Technology, Darmstadt, Germany, in 1983. Prior to founding Qiagen N.V., Dr. Colpan was an Assistant
Investigator at the Institute for Biophysics at the University of Düsseldorf, Germany. Dr. Colpan has a wide range of experience in separation techniques, particularly in the separation and purification of nucleic acids, and has filed many
patents in the field. Dr. Colpan serves on the boards of several biotechnology companies worldwide, including GenPat77 Pharmacogenetics AG, Berlin and MorphoSys AG, Munich, Germany. He is also a member of the board of Qiagen N.V., Venlo, The
Netherlands. In addition, he is a consultant for the federal and state governments of Germany.



Don Soltysiak.    Mr. Soltysiak worked 34 years for Bristol Myers Squibb predominantly in numerous sales management positions and most recently for 16 years as Senior Vice President of Sales
for the U.S. Oncology Division. He retired from Bristol Myers Squibb in 2003 and has since served as a consultant for a variety of pharmaceutical and biotech companies, including OSI Pharmaceuticals, Imclone Systems and Celgene (where he currently
serves on the oncology advisory board). He also currently has a consulting agreement with GPC Biotech, described in greater detail below under Item 7 Major Shareholders and Related Party TransactionsRelated Party Transactions
below. Mr. Soltysiak holds a B.A. from Moravian College, Bethlehem, PA, USA.



James M. Frates.    James Frates is the Chief Financial Officer and directs the Finance and Corporate Communications departments at Alkermes, Inc., a pharmaceutical company based in Cambridge,
Massachusetts. He was previously a Vice President in charge of the East Coast Life Sciences Practice at Robertson Stephens & Company, Inc. He has also worked in health care investment banking at Morgan Stanley & Company, Inc.
Mr. Frates serves as a national chairperson of the Association of Bioscience Financial Officers. Mr. Frates received a B.A. in government from Harvard College and an M.B.A. from Harvard Graduate School of Business Administration.



Peter Preuss.    Peter Preuss is
President and founder of the Preuss Foundation for Brain Tumor Research, and is currently serving a twelve-year term as a Regent of the University of California. He is a former member of the Advisory Committee to the Director of the National
Institutes of Health. Mr. Preuss was founder and Chief Executive Officer of Integrated Software Systems Corporation, one of the worlds first software companies. His extensive business expertise and experience has been recognized by
numerous awards, honors and memberships in Honorary Societies. In 2004, Mr. Preuss received the Woodrow Wilson award for public service. He has been on the boards of various biotech and high-tech companies, both public and private.
Mr. Preuss holds an advanced degree in mathematics from the University of California, San Diego, CA.



Management Board



Our Management Board
currently consists of two members. Since January 1, 2007, three of our Management Board Members retired from their positions: Dr. Mirko Scherer, Ph.D. former Chief Financial Officer left the Company in December 2007; Elmar Maier, Ph.D.,
Chief Operating Officer/Martinsried and



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Senior Vice President, Business Development and Sebastian Meier-Ewert, Ph.D., Senior Vice President and Chief Scientific Officer left the Company in February 2008. All
former Management Board Members currently remain available to the Company as advisors.



The Supervisory Board determines the size of the Management Board. Members of the Management Board are appointed by the Supervisory Board for a maximum term of five years and are eligible for reappointment or extension after
the completion of their term in office. Under certain circumstances, such as a serious breach of duty or a vote of no confidence by the shareholders in an annual meeting, a member of the Management Board may be removed from office by the Supervisory
Board prior to the expiration of his or her term.



The following table
shows the members of the Management Board, their ages, current areas of responsibility, the years in which they were initially appointed, the end of their current terms and membership in statutory supervisory boards in Germany or abroad.



|                                |  |     |  |                     |  |            |  |                         |  |                                         
|------------------------------- |  | --- |  | ------------------- |  | ---------- |  | ----------------------- |  | ----------------------------------------
|Name (age)                      |  | Age |  | Year firstappointed |  | End ofterm |  | Responsibility          |  | Other boardmemberships                  
|Bernd R. Seizinger, M.D., Ph.D. |  | 50  |  | 1998                |  | 3/2012     |  | Chief Executive Officer |  | BioXell SpA andSantheraPharmaceuticalsAG
|                                |  |     |  |                     | 
|Torsten Hombeck, Ph.D.          |  | 38  |  | 2008                |  | 1/2010     |  | Chief Financial Officer |  | FlakeboardAmerica                       



The members of our Management
Board may be contacted at the German address of GPC Biotech.



Bernd
R. Seizinger, M.D., Ph.D.    Chief Executive Officer. Bernd R. Seizinger, M.D., Ph.D., has been Chief Executive Officer of GPC Biotech since 1998. He joined GPC Biotech from Genome Therapeutics Corporation (now Oscient
Pharmaceuticals Corporation) of Waltham, Massachusetts, where he was Executive Vice President and Chief Scientific Officer (19961998). From 1992 to 1996, Dr. Seizinger was at Bristol-Myers Squibb Pharmaceutical Research Institute in
Princeton, New Jersey, where he held the posts of Vice President of Oncology Drug Discovery and, in parallel, Vice President of Corporate and Academic Alliances. From 1984 to 1992, Dr. Seizinger was at Harvard Medical School and Massachusetts
General Hospital, where he served both as Associate Professor of Neuroscience at Harvard Medical School and Associate Geneticist and Director of the Molecular Neuro-Oncology Laboratory at Massachusetts General Hospital. Dr. Seizinger was a
faculty member at the Department of Molecular Biology at Princeton University. He was awarded his M.D. from the Ludwig Maximilians University and his Ph.D. from the Max Planck Institute of Psychiatry, both in Munich. He is the recipient of a
number of scientific awards and has authored over 100 scientific publications. He is a member of the Supervisory Boards of BioXell SpA and Santhera Pharmaceuticals AG.



Torsten Hombeck, Ph.D.    Chief Financial Officer. Dr. Hombeck was promoted to Chief
Financial Officer in January 2008. After joining GPC Biotech in 1999 as Director Finance, Dr. Hombeck most recently served as the Companys Vice President Finance. Prior to his tenure at GPC Biotech, Dr. Hombeck held positions in the
area of Corporate Finance and Controlling at Beiersdorf AG, Hamburg, Germany, where he was responsible for South America. Dr. Hombeck graduated with a Degree in Business Administration from the European Business School in Oestrich-Winkel,
Germany, where he also received his Ph.D. in Finance. Dr. Hombeck is a board member of Flakeboard America Ltd., a North American producer of composite wood products.



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Management Team



Our Management Board is supported by a highly qualified and internationally experienced management team. Certain of the members of the
management team, Messrs. Hamm, Hatzis-Schoch, Freund as well as Dr. George, together with the Management Board form our Executive Committee, which assists the Management Board in key management decisions.



|                               |  |     |  |                                                                  
|------------------------------ |  | --- |  | -----------------------------------------------------------------
|Name (age)                     |  | Age |  | Position                                                         
|David R. Bancroft, Ph.D.       |  | 40  |  | Vice President Intellectual Property                             
|Colin Freund                   |  | 38  |  | Senior Vice President, Business Development & Corporate Planning 
|Martine George, M.D.           |  | 59  |  | Senior Vice President, Drug Development, Chief Medical Officer   
|Bruce Goldsmith, Ph.D.         |  | 42  |  | Vice President, Strategic Marketing                              
|Gregory H. Hamm                |  | 58  |  | Senior Vice President, Human Resources & Corporate Integration   
|Brent Hatzis-Schoch, J.D.      |  | 43  |  | Senior Vice President and General Counsel                        
|Ramona Lloyd, Ph.D.            |  | 44  |  | Vice President World Wide Regulatory Affairs & Quality Compliance
|Thomas J. McKearn, M.D., Ph.D. |  | 60  |  | Vice President Strategic Clinical Affairs                        
|Edward F. McNiff, Ph.D.        |  | 55  |  | Vice President Pharmaceutical Development                        
|Michael E. Petrone, M.D.       |  | 57  |  | Vice President Clinical Operations                               
|Benno Rattel, Ph.D.            |  | 49  |  | Vice President Non-Clinical Development & Toxicology             
|John P. Richard                |  | 50  |  | Senior Business Advisor                                          



David R.
Bancroft.    Co-founder of GPC Biotech and Vice President Intellectual Property. Prior to co-founding GPC Biotech in 1997, Dr. Bancroft was responsible for development and implementation of new automated technologies
at the Max Planck Institute for Molecular Genetics in Berlin, Germany. His previous research positions include those at the Imperial Cancer Research Fund, London, UK, and at Trinity College, Dublin, Ireland, as a Royal Society European Visiting
Fellow. Dr. Bancroft was awarded a Ph.D. in Molecular Population Genetics from the University of Cambridge, UK, for his research within a large-scale and multidisciplinary project. Dr. Bancroft is an inventor on several patents and patent
applications in the fields of molecular biology and automation.



Colin Freund.    Senior Vice President, Business Development & Corporate Planning. Prior to joining GPC Biotech in 2002, he held the position of Vice President Business Development at Double Twist,
Inc., Oakland, CA, where he was responsible for creating alliances with a variety of genomics and proteomics companies. Prior to joining Double Twist, Mr. Freund was a project manager at the Boston Consulting Group, San Francisco, CA, and
London, UK, where he managed assignments in the healthcare and high technology practice areas. Mr. Freund received his BA in Economics and Management Studies from the University of Cambridge, UK, and his MBA from Stanford University, CA.



Martine George.    Senior Vice
President, Drug Development, Chief Medical Officer. Martine George, M.D. joined GPC Biotech in 2006 as Senior Vice President Clinical Development and assumed her present role as Senior Vice President Drug Development and Chief Medical Officer in
2007. Dr. George is an internationally well-known oncology expert with over fifteen years of experience at major pharmaceutical companies, as well as several years in an academic position at the Institute G. Roussy, Villejuif, France.
Prior to joining GPC Biotech, Dr. George was Senior Vice President, Head of Oncology at Johnson & Johnson Pharmaceutical Research and Development. Before that she held a number of executive positions in the areas of clinical and
medical affairs, including at Johnson & Johnson, Rhone-Poulenc Rorer (now part of Sanofi-Aventis), Sandoz Pharmaceuticals Corporation (now Novartis) and American Cyanamid. Dr. George serves as a board member of Cytomics
Pharmaceuticals.



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Bruce Goldsmith.    Vice President, Strategic Marketing. Prior to joining
GPC Biotech in 2007, Dr. Goldsmith held the position of Group Product Director Virology at Tibotec Therapeutics, a subsidiary of Johnson & Johnson. While at Johnson & Johnson, Dr. Goldsmith held various positions of
increasing responsibility in oncology global strategic marketing, business development and licensing and acquisition finance. Prior to joining Johnson & Johnson, Dr. Goldsmith was a research fellow at Novartis Pharma, K.K., where
he conducted scientific research in a neurodegeneration drug discovery group. Dr, Goldsmith received has BA in Biology from Colgate University, NY, his PhD in Neuroscience from University of Pennsylvania, PA and his MBA from Columbia University, NY.



Gregory H. Hamm.    Senior Vice
President, Human Resources & Corporate Integration. Gregory H. Hamm joined GPC Biotech in 1999 as Vice President, Bioinformatics and Information Technology, as well as Site Head of the Princeton facility. In 2001, Mr. Hamm was also
appointed Vice President, Corporate Integration, which includes responsibility for Human Resources worldwide. Mr. Hamm was previously Vice President, Bioinformatics, at Genome Therapeutics Corporation (now Oscient Pharmaceuticals Corporation),
where he was responsible for all computational aspects of the companys scientific programs, including its work on the Human Genome Project. Before 1995, Mr. Hamm was Director of the Molecular Biology Computing Laboratory at Rutgers
University (U.S.). Earlier he was the founder and manager of the EMBL Data Library and Head of Computing at the European Molecular Biology Laboratory (EMBL) in Heidelberg (Germany).



Brent Hatzis-Schoch.    Senior Vice President and General Counsel. Mr. Hatzis-Schoch joined GPC
Biotech in 2003. Prior to joining GPC Biotech, Mr. Hatzis-Schoch was Associate General Counsel for Global Research & Development at Pharmacia Corporation, where he earlier held various senior legal positions in the transactional and
international areas. Previously, he had been European legal counsel to Baxter Healthcare, based in Brussels, Belgium. He also spent several years in private practice in the United States and Germany. Mr. Hatzis-Schoch received his law degree
from George Washington University, Washington D.C.



Ramona
Lloyd.    Vice President World Wide Regulatory Affairs & Quality Compliance. Dr. Lloyd has fifteen years of pharmaceutical regulatory experience and has held senior regulatory positions at major
pharmaceutical companies. She joined GPC Biotech from Bristol-Myers Squibb, where she was Vice President, Global Regulatory Operations. At GPC Biotech she will have worldwide responsibility for Responsibility for Regulatory Affairs, Quality
Compliance and Document Management.



Thomas J.
McKearn.    Vice President Strategic Clinical Affairs. Dr. McKearn is responsible for the design and implementation of our clinical and regulatory development strategy for new lead candidates as they enter
development through eventual registration and commercialization. His responsibilities include oversight of all clinical study protocols, selection of investigators, and the review and analysis of study results. His position also serves as the
primary point of contact with worldwide regulatory agencies and health authorities. Furthermore, Dr. McKearn plays a key role in our compound in-licensing strategy. Prior to joining GPC Biotech in 2002, Dr. McKearn held several executive
positions both in biotech and in the pharmaceutical industry. He was a founder and Chief Executive Officer of Cytogen (now EUSA Pharma). His most recent position was Executive Director Strategic Science & Medicine at Bristol-Myers Squibb
Company, Pharmaceutical Research Institute.



Edward F.
McNiff.    Vice President Pharmaceutical Development. Prior to joining GPC Biotech in 2002, Dr. McNiff held several positions at Bristol-Myers Squibb Company. His most recent position was Vice President Analytical
Research and Development at Bristol-Myers Squibb Company, Pharmaceutical Research Institute, supporting pharmaceutical development activities spanning the identification of new drug candidates through registration, launch and life-cycle activities.
Dr. McNiff is responsible for the design and implementation of our pharmaceuticals development strategy for new



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lead candidates as they enter development through eventual registration and commercialization. These responsibilities include analytical and process chemistry, dosage
form development, quality assurance, metabolism and pharmacokinetics.



Michael E. Petrone.    Vice President Clinical Operations. Dr. Petrone is responsible for overall management of investigational clinical trial operations, including Phase 1 through Phase 3 trials
through to eventual trial completion and registration. These responsibilities include clinical trial outsourcing. He has more than 15 years of experience in the pharmaceutical and biotechnology industry in the areas of clinical trials management and
outsourcing, strategic planning, product development, and clinical research from the initiation of clinical trials to marketing approval. Prior to joining GPC Biotech in 2002, Dr. Petrone held several executive positions both in the
pharmaceutical industry and biotech. He most recent positions were with Roberts Pharmaceutical Corporation and Principia Pharmaceuticals.



Benno Rattel.    Vice President Nonclinical Development. Prior to joining GPC Biotech in 2001, he held the position of Director of
Nonclinical Drug Development at Fujisawa Germany, where he was responsible for the departments of pharmacology, safety pharmacology, toxicology as well as the steering of scientific contract research. Prior to that, Dr. Rattel was Head of
Toxicology at Klinge Pharma and supported Fujisawa/Osaka as a toxicological consultant. Dr. Rattel has more than 20 years of working experience in the pharmaceutical industry, is a veterinarian by training, received his PhD at the
Ludwig-Maximilian-University Munich, is board certified as a pharmacologist and toxicologist as well as a specialist in animal welfare and has received a training in toxicological pathology. He is a member of the government-appointed regional animal
welfare commission.



John P.
Richard.    Senior Business Advisor. John Richard joined GPC Biotech in 1999. Previously, he was Executive Vice President, Business Development at SEQUUS Pharmaceuticals, where he was responsible for negotiating the
acquisition of SEQUUS by ALZA Corporation in 1999. Prior to SEQUUS, Mr. Richard headed business development for Vivus and Genome Therapeutics Corporation (now Oscient Pharmaceuticals Corporation), where he was responsible for establishing
numerous pharmaceutical alliances. He was also co-founder and original Chief Executive Officer of IMPATH Inc. Mr. Richard currently serves on the Board of Directors of Altus Pharmaceuticals Inc., Targacept, Inc., Zygogen, LLC, Zosano Pharma,
Inc., Stheno Corporation, and Abeome Corporation. He is also a partner with Georgia Venture Partners. Mr. Richard received his MBA from Harvard Business School and his B.S. from Stanford University.



None of the above members of our Management Board, Supervisory Board or management team
have any family relationship with any other member of the Management Board, Supervisory Board or management team. None of the above members of the Management Board, Supervisory Board or management team were appointed pursuant to an agreement or
understanding between such member of the Management Board, Supervisory Board or management team and any third party.



Compensation of Management Board and Supervisory Board Members



Compensation of Members of the Management Board



We have entered into service agreements with both members of our Management Board. These agreements generally provide for a base salary and an annual
performance-based bonus, although no cash bonuses were paid during 2007. For a discussion of the stock option and similar plans in which the members of our Management Board participate, see Equity-Based Plans. In addition to these
fixed and variable remuneration components, under the terms of their service agreements, the members of our Management Board are entitled to specific insurance benefits (including accident and D&O insurance) and reimbursement of necessary and
reasonable disbursements.



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We believe that the service agreements between GPC Biotech and the members of our Management Board provide for
payments and benefits (including upon termination of employment) that are in line with customary market practices.



In the event of a change in control and termination of employment within a specified period thereafter Dr. Seizinger is entitled to 300 % of the sum of
his respective highest annual salary on or after the date of the change in control and the average of his last two annual bonuses, if any, received prior to the change in control. In the event of a change in control and termination of employment
within a specified period thereafter Dr. Hombeck is entitled to 225 % of the sum of his respective highest annual salary on or after the date of the change in control. In addition, subject to the term of the stock options and convertible
bonds under the terms and conditions of the relevant plan or program (see Equity Based Plans), stock options and convertible bonds granted to the members of our Management Board are fully vested and may no longer be terminated upon
a change in control. A change in control will have occurred (pursuant to applicable German corporate law) if, as a result of any takeover, exchange or other transfer, a single shareholder or a group of shareholders acting in concert acquires more
than 50 % of the outstanding voting rights in GPC Biotech or, if as a result of a merger or reverse merger the shareholders of GPC Biotech prior to the effective date of such transaction cease to own more than 50 % of the outstanding
voting shares in the merged entity. Furthermore, Dr. Seizinger, the Chairman of our Management Board, is entitled to severance benefits in the amount of 200 % of the sum of his last annual salary and the average of his last two annual
bonuses in the event that our Supervisory Board determines to terminate his appointment as Chairman of the Management Board and not to extend his service agreement beyond March 2012. Dr. Hombeck is entitled to severance benefits in the amount
of 100 % of his respective last annual salary in the event that our Supervisory Board determines not to renew his service agreements beyond its current term.



2007 Summary Compensation Table (in ):



|                                |  |                     |     |  |           |  |                                 |  |                       |     |  |                  
|------------------------------- |  | ------------------- | --- |  | --------- |  | ------------------------------- |  | --------------------- | --- |  | -----------------
|                                |  | Annual Compensation
|                                |  | Salary              |     |  | CashBonus |  | Fair ValueofConvertibleBonds(1) |  | All OtherCompensation |     |  | TotalCompensation
|Bernd R. Seizinger, M.D., Ph.D. |  | 467,215             | (2) |  |          |  | 6,123,150                       |  | 36,662                | (3) |  | 6,627,027        
|Elmar Maier, Ph.D.              |  | 293,429             |     |  |          |  | 1,026,710                       |  |                      |     |  | 1,320,139        
|Sebastian Meier-Ewert, Ph.D.    |  | 320,989             |     |  |          |  | 1,026,710                       |  |                      |     |  | 1,347,699        
|Mirko Scherer, Ph.D.(4)         |  | 291,404             |     |  |          |  | 1,026,710                       |  |                      |     |  | 1,318,114        
|                                |  |                     |     |  |           |  |                                 |  |                       |     |  |                  
|Total                           |  | 1,373,037           |     |  |          |  | 9,203,280                       |  | 36,662                |     |  | 10,612,979       
|                                |  |                     |     |  |           |  |                                 |  |                       |     |  |                  



|(1) | Granted in 2007.
|--- | ----------------

|(2) | Includes $ 278,320 which has been converted into euro at the US$/euro exchange rate of $ 1.00 = 0.7308 (average exchange rate during the year).
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------

|(3) | This amount represents a double household allowance.
|--- | ----------------------------------------------------

|(4) | Dr. Scherer resigned on December 4, 2007, and as compensation for the termination of his Service Agreement by mutual
consent, Dr. Scherer is entitled to receive a severance payment in the gross amount of  312,000 payable in twelve equal monthly installments, starting on
January 1, 2008; provided, however, that if and when Dr. Scherer enters into full-time employment or a management position with a third party, he shall only be entitled to receive a pro-rata portion of the severance payment up to and
excluding the new employment date. In addition, the exercise period for 50,000 of his vested options was extended to three years, effective December 4, 2007, which was accounted for as a modification of share-based payment awards in the
accompanying consolidated financial statements.
|--- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



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Compensation of Members of the Supervisory Board



Our Articles of Association provide that the Chairman of our Supervisory Board receive
an annual fixed remuneration of  35,000 in cash, that the Vice Chairman receive an annual fixed remuneration of  25,000 in cash and that all other members of our Supervisory Board receive an annual fixed remuneration of  15,000 in cash. In addition, members of our Supervisory Board who serve on Supervisory Board committees receive cash-based remuneration in addition to their annual fixed remuneration as follows: for activity as chairman of one or
more committees (other than the Audit Committee), a member of the Supervisory Board receives an additional  5,000 (plus any value added tax on such amount)
annually, and, for activity as a member of a committee (other than the Audit Committee), a member of the Supervisory Board receives an additional  2,500 (plus any
value added tax on such amount) annually. The chairman of the Audit Committee receives an additional  10,000 (plus any value added tax on such amount) annually and
the other members of the Audit Committee each receive an additional  5,000 (plus any value added tax on such amount) annually. The members of the Audit Committee
do not receive any additional cash-based remuneration for their service on any other committee.



Our Articles of Association also provide that each Supervisory Board member receives an annual compensation of 7,500 in the form of stock appreciation rights, or
SARs, that vest upon certain performance conditions. The stock appreciation rights are granted annually on the first day of the first month after our annual shareholders meeting or on June 1, 2007 for the past year. Dr. Drews, as the
Chairman of the Supervisory Board, and Mr. Lytton, as the Vice Chairman of the Supervisory Board, received grants of 15,000 and 11,250 stock appreciation rights, respectively. Each member of the Supervisory Board received grants of 7,500 stock
appreciation rights. In addition, each member of the Supervisory Board (including the Chairman of the Supervisory Board) who serves as the chairman of one or more Supervisory Board committees (other than the Audit Committee) received a grant of
5,000 stock appreciation rights. Furthermore, each member of the Supervisory Board, but excluding those members who are members of the Audit Committee, received grants of 2,500 stock appreciation rights in compensation for their service on one or
more committees. The chairman and members of the Audit Committee received grants of 7,500 and 3,750 stock appreciation rights, respectively. The members of the Audit Committee do not receive any additional stock appreciation rights for their service
on any other committee.



Each stock appreciation right represents the
right to receive an amount in cash equal to the difference (if any) between the basic price of the stock appreciation right and the exercise price of the stock appreciation right after the completion of a specified holding period. The basic price of
each stock appreciation right is  21.03 for the SARs issued in 2007, which is equal to the average closing price of our ordinary bearer shares at the XETRA closing
auction of the Frankfurt stock exchange for the five trading days preceding, and the five trading days after, the issue date. The exercise price will be the average closing price of our ordinary bearer shares at the XETRA closing auction of the
Frankfurt stock exchange for the 60 trading days following the end of the holding period. The holding period of the stock appreciation rights began on the issue date and will end with the acceptance by the FDA of an NDA filing for satraplatin in an
indication other than second-line hormone refractory prostate cancer. Any payments with respect to the stock appreciation rights are due within 100 calendar days after the end of the holding period.



The members of the Supervisory Board will receive the full cash payment with respect to
their stock appreciation rights only if they are still members of the Supervisory Board and/or the respective committee at the end of the holding period. If a member leaves the Supervisory Board and/or the respective committee before the end of the
holding period, the member will receive only a pro-rated cash payment, based on the length of the term of service on the Supervisory Board and/or membership on the committee, with respect to his or her stock appreciation rights. In the case of a
change in control of GPC Biotech, as defined in the German Securities Acquisition and Takeover Act



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(Wertpapiererwerbs- und Übernahmegesetz), the holding period will end on the acquisition date. In this case, the 60 trading days directly preceding the
acquisition date will be used to determine the exercise price. Transfer of the stock appreciation rights, including assignment, sale, pledge, grant of sub-rights or the foundation of a trust, is not permissible and will result in a forfeiture of the
stock appreciation rights. Any transaction that bears financial comparison with a sale of the stock appreciation rights is not permissible and will also lead to a forfeiture of the stock appreciation rights.



Furthermore, we reimburse our Supervisory Board members for out-of-pocket expenses
incurred in connection with their services and, to the extent applicable, any value added tax on this compensation.



We have no contracts with any of our Supervisory Board members that would provide for benefits upon termination of service on the Supervisory Board.



2007 Summary Compensation Table



|                                      |  |            |  |                                
|------------------------------------- |  | ---------- |  | -------------------------------
|Name                                  |  | Salary () |  | Stockappreciationrights(number)
|Jürgen Drews, M.D., Ph.D.(1)(5)       |  | 40,000     |  | 20,000                         
|Michael Lytton, J.D.(2)(4)(6)         |  | 30,000     |  | 15,000                         
|Metin Colpan, Ph.D.(4)(8)             |  | 20,000     |  | 11,250                         
|Prabhavathi B. Fernandes, Ph.D.(8)(9) |  | 6,952      |  |                               
|Donald Soltysiak.(8)(10)              |  | 10,548     |  | 10,000                         
|James M. Frates(3)(8)                 |  | 25,000     |  | 15,000                         
|Peter Preuss(6)(7)                    |  | 22,500     |  | 12,500                         
|                                      |  |            |  |                                
|Total                                 |  | 155,000    |  | 83,750                         



|(1) | Chairman of the Supervisory Board.
|--- | ----------------------------------

|(2) | Vice Chairman of the Supervisory Board.
|--- | ---------------------------------------

|(3) | Chairman of the Audit Committee.
|--- | --------------------------------

|(4) | Member of the Audit Committee.
|--- | ------------------------------

|(5) | Chairman of the Compensation Committee.
|--- | ---------------------------------------

|(6) | Member of the Compensation Committee.
|--- | -------------------------------------

|(7) | Chairman of the Corporate Governance & Nominations Committee.
|--- | -------------------------------------------------------------

|(8) | Member of the Corporate Governance & Nominations Committee.
|--- | -----------------------------------------------------------

|(9) | Membership terminated on May 24, 2007.
|--- | --------------------------------------

|(10) | Elected to Supervisory Board on May 246, 2007.
|---- | ----------------------------------------------



Equity-Based Plans



As of December 31, 2007, a total of 3,616,376 stock options and convertible bonds were issued and outstanding to purchase our ordinary bearer shares to members
of our Management Board and a total of 116,500 stock options and convertible bonds to the members of our Supervisory Board. In 2000, we granted 20,000 options and convertible bonds to our Supervisory Board members at exercise prices of 17.89 euros
and in 2001, we granted 10,000 options and convertible bonds to our supervisory board members at exercise prices of 16.38 euros, each with a term of 10 years. In 2003, we granted 86,500 options and convertible bonds to our supervisory board members
at exercise prices of 5.77 euros, which only had a five year term and expired on May 31, 2008. No other options or convertible bonds were issued to members of the supervisory board.



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Management Board Members:



|           |  |                                                          |  |                 |  |                    |  |                  
|---------- |  | -------------------------------------------------------- |  | --------------- |  | ------------------ |  | -----------------
|Grant year |  | Options/convertible bonds issued and outstanding(number) |  | Conversion rate |  | Exercise price () |  | Term life (years)
|2000       |  | 168,000                                                  |  | 1:1             |  | 6.62               |  | 10               
|           |  | 440,000                                                  |  | 1:1             |  | 17.89              |  | 10               
|2001       |  | 90,000                                                   |  | 1:1             |  | 9.69               |  | 10               
|           |  | 50,000                                                   |  | 1:1             |  | 13.34              |  | 10               
|2002       |  | 32,250                                                   |  | 1:1             |  | 4.36               |  | 10               
|2003       |  | 17,064                                                   |  | 1:1             |  | 4.87               |  | 10               
|           |  | 50,562                                                   |  | 1:1             |  | 4.96               |  | 10               
|2004       |  | 500,000                                                  |  | 1.1             |  | 9.33               |  | 10               
|           |  | 545,000                                                  |  | 1:1             |  | 10.90              |  | 10               
|2005       |  | 420,000                                                  |  | 1:1             |  | 10.38              |  | 10               
|2006       |  | 552,500                                                  |  | 1:1             |  | 16.03              |  | 10               
|2007       |  | 661,000                                                  |  | 1:1             |  | 21.30              |  | 10               
|           |  |                                                          |  |                 |  |                    |  |                  
|Total      |  | 3,616,376                                                |  |                 |  |                    |  |                  



We have established the
following equity compensation plans for members of our Management Board, executives of our U.S. subsidiary and selected employees of GPC Biotech as well as consultants and members of our Supervisory Board:



German Equity-Based Plans



2007 through 2000 Stock Option Plans



We have established a new stock option plan each year from 2000 through 2007, with the
exception of 2003. Under the 2007 through 2005 Stock Option Plans, employees of GPC Biotech and affiliated subsidiary companies (nachgeordnete verbundene Unternehmen) in Germany and abroad are eligible to acquire our ordinary shares pursuant
to stock options. Under the 2004 Stock Option Plan, the members of the management bodies and executives (Führungskräfte) of GPC Biotech and its affiliated subsidiary companies in Germany and abroad are eligible to acquire our
ordinary shares pursuant to stock options. Under the 2002 Stock Option Plan, the members of our Management Board and selected employees of GPC Biotech are eligible to acquire our ordinary shares pursuant to stock options. Under the 2001 Stock Option
Plan, selected employees of GPC Biotech, members of our Management Board and members of the management bodies of our affiliates (verbundene Unternehmen) are eligible to acquire our ordinary shares pursuant to stock options. Under the 2000
Stock Option Plan, selected employees of GPC Biotech, members of our Management Board, members of the management bodies of our affiliates as well as members of the Supervisory Board and consultants are eligible to acquire our ordinary shares
pursuant to stock options.



Stock options may be granted under the plans
at an exercise price determined on the basis of the average closing price for our ordinary shares as quoted in the XETRA closing auction on the Frankfurt Stock Exchange during the last five stock exchange trading days prior to the date of grant. In
addition, under the 2000 Stock Option Plan, the exercise price for the stock options granted to optionees under this plan prior to our initial public offering in 2000, was determined on the basis of the fair market value of our shares. The exercise
price is subject to adjustment upon changes in our capitalization and must at all times be at least equal to the notional nominal value (the amount attributable to each of our ordinary shares) of our ordinary shares (currently 1.00 per ordinary share). The Management Board, and, to the extent that our Management Board is concerned, the Supervisory Board, selects the eligible persons to
whom options will be granted and determines the grant date,



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amounts, exercise price, vesting periods and other relevant terms of the stock option grants (including acceleration provisions) in accordance with the provisions of
the respective plans. The details of any grants of stock options to members of our Supervisory Board under the terms of the 2000 Stock Option Plan were approved by our shareholders.



A stock option granted under any of the 2007 through 2000 Stock Option Plans may not be exercised until the occurrence of each of the
following events: (i) the stock option satisfies a two-year waiting requirement (measured from the date of grant) and (ii) the stock option vests. In addition, a stock option granted under the 2002 Stock Option Plan, the 2001 Stock Option
Plan or the 2000 Stock Option Plan may not be exercised until the price of our ordinary bearer shares exceeds the exercise price of the stock option on five successive stock exchange trading days (10 days in the case of the 2000 Stock Option Plan)
within one month prior to exercise by a certain percentage (which percentage is ten % for the first year after the expiration of the two-year waiting period and is increased by five % for each year thereafter). Further, a stock option granted under
the 2007 through 2004 Stock Option Plans may not be exercised until the price of our shares develops better than a reference index, which is the Prime IG Biotechnology Index of the Frankfurt Stock Exchange for the 2004 and 2005 Stock Option Plans
and the TecDax Index of the Frankfurt Stock Exchange for the 2006 and 2007 Stock Option Plans. In addition, pursuant to the 2007 through 2001 Stock Option Plans, a stock option may only be exercised within a period of six weeks after publication of
our quarterly reports or annual financial statements, and may not be exercised during a subscription rights offering by GPC Biotech prior to the commencement of ex subscription rights trading on the Frankfurt Stock Exchange and during
the period from December 24 to December 31 of each calendar year. Furthermore, pursuant to the 2000 Stock Option Plan, a stock option may only be exercised during four designated exercise periods lasting one month each that begin on the
third bank working day after publication of our quarterly reports; and stock options may not be exercised during a subscription rights offering by GPC Biotech prior to the commencement of ex subscription rights trading on the Frankfurt
Stock Exchange.



In the event of the termination of service of an
optionee, the unvested portion of any stock option grant is generally forfeited, and the vested and exercisable portion is terminated (i) six months after a termination of service due to the death of the optionee in the case of the 2007 through
2004 Stock Option Plans and 130 business days in case of the 2002 through 2000 Stock Option Plans or (ii) three months after termination of employment for any other reason in the case of the 2007 through 2004 Stock Option Plans (90 business
days in the case of the 2002 Stock Option Plan and 30 business days in the case of the 2001 Stock Option Plan and the 2000 Stock Option Plan). In extraordinary circumstances (such as maternity leave, permanent disability or early retirement and
similar circumstances), our Management Board, and, to the extent that our Management Board is concerned, the Supervisory Board, may abstain from terminating the stock option grants.



Notwithstanding the foregoing, a stock option may not be exercised following the expiration of its term, which under the plans cannot
exceed ten years from the date of grant. A stock option is generally not transferable during the life of the optionee, but is inheritable upon the death of the optionee.



In the event of a merger with or into another entity (Verschmelzung), a change in our legal form (Umwandlung), a change in the notional
nominal value of our ordinary shares and similar measures leading to the cancellation or conversion of the shares underlying the stock options, each outstanding stock option will be substituted by the right to purchase at the exercise price a
specific number of shares or other interests (calculated on the basis of the fair market value of our ordinary bearer shares at the time of any such change) substituting our ordinary shares. In addition, our 2002 through 2000 Stock Plans provide
that in the case of an issuance of new shares, stock options or convertible bonds with subscription rights for existing shareholders, the exercise prices of stock options issued under those plans will be reduced in the same ratio as the average
trading price of the



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subscription rights of existing shareholders on all trading days in the XETRA auction at the Frankfurt Stock Exchange relates to the price of one share of GPC Biotech
in XETRAs final auction on the last trading day before the end of the subscription period.



Our Management Board, together with our Supervisory Board, and, to the extent that our Management Board is concerned, the Supervisory Board alone, may determine
that, in lieu of the issuance of new shares out of the specifically created conditional capital, shares acquired by GPC Biotech through market purchases or otherwise in accordance with applicable German stock corporation law may be issued to
optionees upon exercise of the stock options. In respect of the 2000 Stock Option Plan, our Management Board, together with our Supervisory Board, and, to the extent that our Management Board is concerned, the Supervisory Board alone, may
additionally determine that, in lieu of the issuance of new ordinary shares out of the specifically created authorized and conditional capitals, new ordinary shares issued out of additional authorized or conditional capitals may be issued to
optionees upon exercise of the stock options or that stock options may be settled in cash, at the Companys discretion.



1999 and 1997 Stock Option Plans



Under the 1999 and 1997 Stock Option Plans, the members of our Management Board and Supervisory Board as well as selected employees and consultants are eligible to
acquire our ordinary shares pursuant to stock options.



The terms of the
1999 and 1997 Stock Option Plans are substantially similar to the terms of the stock option plans discussed in 2007 through 2000 Stock Option Plans above, with the following exceptions:



| |  | the exercise price for the stock options granted to optionees under the 1999 and 1997 Stock Option Plans was determined on the basis of the fair market value of our ordinary shares;
| | - | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  | a stock option granted under the 1999 and 1997 Stock Option Plans may only be exercised if the price of our ordinary bearer shares exceeds the exercise price of the stock option on five
successive bank working days within one month prior to exercise by a certain percentage (which percentage is 15 % for the first year after the expiration of the two-year waiting period and is increased by five % for each year thereafter);
| | - | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  | a stock option granted under the 1999 and 1997 Stock Option Plans is generally transferable during the life of the optionee;
| | - | ----------------------------------------------------------------------------------------------------------------------------



| |  | the periods during which stock options may be exercised deviate slightly from those under the 2002 Stock Option Plan and the 2001 Stock Option Plan;
| | - | ----------------------------------------------------------------------------------------------------------------------------------------------------



| |  | in the event of a termination of the stock options granted under the 1999 and 1997 Stock Option Plans, the optionees have to be compensated in an amount equal to the lower of (1) the
fair value of the terminated stock options and (2) the amount of income tax paid at the time of grant; and
| | - | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  | stock options issued under the 1999 Stock Option Plan may be settled in cash at the Companys discretion.
| | - | ---------------------------------------------------------------------------------------------------------



U.S. Equity-Based Plans



Under the 2007 through 2004 Stock Option Plans, selected employees of GPC Biotech and directors of our U.S. subsidiary are eligible to acquire our ordinary shares
pursuant to stock options. Under the 2002 Incentive Stock Option Plan and the 2001 Incentive Stock Option Plan, selected employees of GPC Biotech and employee directors of our U.S. subsidiary and members of our Management Board are eligible to
acquire our ordinary shares pursuant to stock options. Under the



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2000 Incentive Stock Option Plan and the 1999 Incentive Stock Option Plan, selected employees and employee directors of our U.S. subsidiary, members of our Management
Board and consultants of GPC Biotech, as well as members of the Supervisory Board residing in the United States, are eligible to acquire our ordinary shares pursuant to stock options.



Until 2007, stock options granted under these plans may be incentive stock options, or ISOs, which are intended to qualify for
favorable U.S. federal income tax treatment under the provisions of Section 422 of the U.S. Internal Revenue Code of 1986, as amended, or U.S. Internal Revenue Code, or non-qualified stock options, or NSOs, which do not so qualify. The
aggregate fair market value of the ordinary shares represented by any given optionees ISOs that become exercisable for the first time in any calendar year may not exceed US $100,000. Stock options in excess of this limit are treated as NSOs.
We ceased to offer options intended to qualify as ISOs in 2007; accordingly all options granted from January 1, 2007 are non-qualified stock options.



The Management Board, and, to the extent that our Management Board is concerned, the Supervisory Board, selects the eligible persons to whom stock option, will be
granted and determines the grant date, amounts, exercise price, vesting periods and other relevant terms of the stock option grants (including acceleration provisions) in accordance with the provisions of the respective plans, including whether the
options are intended to be ISOs or NSOs. Under the plans, employees are eligible to receive grants of ISOs and NSOs, while directors of our U.S. subsidiary and members of our Management Board and consultants are eligible to receive grants of NSOs
only. Stock option grants to members of the Management Board require the approval of the Supervisory Board. The details of any grants of stock options to members of our Supervisory Board under the terms of the 2000 Incentive Stock Option Plan and
the 1999 Incentive Stock Option Plan were approved by our shareholders. The exercise price of options granted under the plans can be determined by the Management Board, and, to the extent that our Management Board is concerned, the Supervisory Board
within specific parameters fixed by our shareholders in the respective resolutions relating to the several plans.



A stock option granted under any of our U.S. stock option plans may not be exercised until the occurrence of each of the following events: (i) the stock option
satisfies a two-year waiting requirement (measured from the date of grant) and (ii) the stock option vests. Furthermore, a stock option granted under the 2002 Stock Option Plan, the 2001 Stock Option Plan, the 2000 Stock Option Plan, or the
1999 Incentive Stock Option Plan may not be exercised until the price of our ordinary shares exceeds the exercise price of the stock option on five successive stock exchange trading days, or bank working days in the case of the 2000 Incentive Stock
Option Plan and the 1999 Incentive Stock Option Plan, during the one month prior to exercise by a certain percentage (which percentage is ten percent, 15% in the case of stock options granted under the 1999 Stock Option Plan, for the first year
after the expiration of the two-year waiting period and is in each case increased by five percent for each year thereafter). Likewise, a stock option granted under the 2007 Stock Option Plan, the 2006 Incentive Stock Options Plan and 2005 Incentive
Stock Option Plan may not be exercised unless the price of our shares develops better than a reference index (which is the TecDax Index of the Frankfurt Stock Exchange in the case of the 2007 Stock Option Plan, the 2006 Incentive Stock Option Plan
and the Prime IG Biotechnology Index of the Frankfurt Stock Exchange in the case of the 2005 Incentive Stock Option Plan), during the four weeks prior to the date of exercise and a stock option granted under the 2004 Stock Option Plan may not be
exercised unless the price of our shares develops better than the weighted average of the Prime IG Biotechnology Index of the Frankfurt Stock Exchange and the Nasdaq Biotech Index during the four weeks prior to the date of exercise. In addition,
pursuant to the 2005 Incentive Stock Option Plan, the 2004 Incentive Stock Option Plan, the 2002 Incentive Stock Option Plan and the 2001 Incentive Stock Option Plan, a stock option may only be exercised within a period of six weeks after
publication of our quarterly reports or annual financial statements, and may not be exercised during a subscription rights offering by GPC Biotech and during the period from December 24 to December 31 of each calendar year. Furthermore,
pursuant to the 2000 Incentive



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Stock Option Plan and the 1999 Incentive Stock Option Plan, a stock option may only be exercised during four designated exercise periods lasting one month each that
begin on the third bank working day after publication of our annual report and our quarterly reports; and stock options may not be exercised during a subscription rights offering by GPC Biotech.



In the event of the termination of service of an optionee, the unvested portion of a
stock option is generally forfeited, and the vested and exercisable portion generally terminates six months (eighteen months in the case of the 2002 Stock Option Plan, the 2001 Stock Option Plan, the 2000 Stock Option Plan, or the 1999 Incentive
Stock Option Plan) after a termination of service due to the death of the optionee, three months (twelve months in the case of the 2002 Stock Option Plan, the 2001 Stock Option Plan, the 2000 Stock Option Plan, or the 1999 Incentive Stock Option
Plan) after a termination of service due to the permanent disability of the optionee or three months after termination of employment for any other reason. Notwithstanding the foregoing, a stock option may not be exercised following the expiration of
its term, which under the plans cannot exceed ten years from the date of grant. A stock option is generally not transferable during the life of the optionee, but is inheritable upon the death of the optionee.



In the event of a merger with or into another entity (Verschmelzung), a change
in our legal form (Umwandlung), a change in the notional nominal value of our ordinary shares and similar measures leading to the cancellation or conversion of the shares underlying the stock options, each outstanding stock option will be
substituted by the right to purchase at the exercise price a specific number of shares or other interests (calculated on the basis of the fair market value of our ordinary bearer shares at the time of any such change) substituting our ordinary
shares.



In addition, our 2002 and 2001 Incentive Stock Option Plans
provide that in the case of an issuance of new shares, stock options or convertible bonds with subscription rights for existing shareholders, the exercise prices of stock options issued under those plans will be reduced in the same ratio as the
average trading price of the subscription rights of existing shareholders on all trading days in the XETRA auction at the Frankfurt Stock Exchange relates to the price of one share of GPC Biotech in XETRAs final auction on the last trading day
before the end of the subscription period.



Other statutory adjustment
events may apply to all our stock options and convertible bonds in accordance with mandatory German law.



Mitotix, Inc. 1996 Equity Incentive Plan



In connection with the acquisition of Mitotix, we assumed the outstanding stock options under the Mitotix, Inc. 1996 Equity Incentive Plan. The former employees,
officers, directors and consultants of Mitotix were eligible to participate in the plan. The plan was terminated as of February 24, 2000, and the optionees are now eligible to participate in our equity plans.



Convertible Bond Programs



On May 25, 2007, May 24, 2006, June 8,
2005, August 31, 2004, on May 21, 2003, and on June 11, 2002, respectively, our shareholders approved the implementation of the 2007 Convertible Bond Program, 2006 Convertible Bond Program, the 2005 Convertible Bond Program, 2004
Convertible Bond Program, the 2003 Convertible Bond Program and the 2002 Convertible Bond Program. Under these programs, members of the Management Board, members of the management bodies and other employees of GPC Biotech and its affiliated
subsidiary companies and, with the exception of the 2004 and the 2007 Convertible Bond Programs, consultants are eligible to acquire our ordinary shares pursuant to convertible bonds, with a nominal value 1.00 per convertible bond.



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The Management Board, together with the Supervisory Board, and, to the extent that our Management Board is
concerned, the Supervisory Board alone, determines whether the ordinary shares underlying the convertible bonds will be made available from these conditional capitals or from a program to repurchase our ordinary shares.



The Management Board, and to the extent that our Management Board is concerned, the
Supervisory Board, selects the eligible persons to whom convertible bonds will be offered and determines the amounts, vesting periods and other relevant terms (including acceleration provisions) of the convertible bonds.



Convertible bonds issued pursuant to our convertible bond programs may be exercised by
the bondholder, after expiry of the two-year waiting period from the date of issuance, to obtain one ordinary share for each convertible bond upon payment of the conversion price and bear interest at 3.5% per annum starting from the date of
issuance. The convertible bonds may be offered to the eligible persons for subscription within the last 15 working days of each calendar month. The time to maturity of the convertible bonds is ten years from the date of issuance, after which the
convertible bonds lapse without compensation to the bondholder (other than repayment of the nominal amount of the convertible bond plus accrued interest). Convertible bonds are generally not transferable during the life of the bondholder, except to
a credit institution specified by GPC Biotech following the expiration of the two-year waiting period or of the cancellation period described below.



Under any of our convertible bond programs, ordinary shares issued upon exercise of a convertible bondprovided that they are issued before the beginning of
our annual general meeting that resolves on the allocation of retained earningsare entitled to dividends from the beginning of the previous fiscal year. In the event that the ordinary shares are issued after our general meeting, such ordinary
shares are entitled to dividends in the fiscal year in which they were issued.



Convertible bonds issued under our convertible bond programs generally vest and become uncancellable in one-quarter installments on each of the first four anniversaries of the date of issuance. A convertible bond may not be exercised until
the occurrence of each of the following events: (i) satisfaction of a two-year waiting requirement (measured from the date of issuance); (ii) vesting; and (iii) the achievement of a share price performance goal on the date of
exercise. Convertible bonds issued pursuant to the 2007 Convertible Bond Program, the 2006 Convertible Bond Program, the 2005 Convertible Bond Program and the 2004 Convertible Bond Program, however, may not be exercised unless the price of our
shares develops better than a reference index, which is the TecDax Index of the Frankfurt Stock Exchange in the case of the 2007 and 2006 Convertible Bond Programs and the Prime IG Biotechnology Index of the Frankfurt Stock Exchange in the case of
the 2005 and 2004 Convertible Bond Programs, in each case during the four weeks prior to the date of exercise. With respect to convertible bonds issued pursuant to the 2003 Convertible Bond Program, the price of our ordinary shares on the Frankfurt
Stock Exchange on the date of exercise exceeds the share price on May 21, 2003 by 100%. With respect to convertible bonds issued pursuant to the 2002 Convertible Bond Program, the price of our ordinary shares on the Frankfurt Stock Exchange
must exceed the exercise price of the convertible bonds on five successive trading days within one month prior to exercise by a certain percentage (which percentage is ten percent for the first year after the expiration of the two-year waiting
period and is increased by five percent for each year thereafter). In addition, pursuant to any of our convertible bond programs, a convertible bond may only be exercised within a period of six weeks after publication of our quarterly reports or
annual financial statement, and may not be exercised during a subscription rights offering by GPC Biotech and during the period from December 24 to December 31 of each calendar year. Notwithstanding the foregoing, convertible bonds may not
be exercised following the expiration of their respective terms, which under the plans cannot exceed ten years from the date of grant. The convertible bonds are generally not transferable during the life of the bondholder, but are inheritable upon
the death of the bondholder.



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In the event of the termination of service of a bondholder, the unvested portion of a convertible bond may be
cancelled without compensation (other than repayment of the nominal amount of the convertible bond plus accrued interest), and the vested portion is generally cancelled 12 months after the termination of service. In addition, GPC Biotech has the
right to cancel a bondholders convertible bonds in the event insolvency proceedings are instituted against the assets of such bondholder or the convertible bonds are attached by a creditor of such bondholder for more than six months. A
bondholder may cancel his or her convertible bonds with three months notice at the end of a quarter.



In addition, our 2004, 2003 and 2002 Convertible Bond Programs provide that in the case of an issuance of new shares, stock options or convertible bonds with
subscription rights for existing shareholders, the conversion prices of convertible bonds issued under those plans will be reduced in the same ratio as the average trading price of the subscription rights of existing shareholders on all trading days
in the XETRA auction at the Frankfurt Stock Exchange relates to the price of one share of GPC Biotech in XETRAs final auction on the last trading day before the end of the subscription period.



Shares Reserved and Securities Issued and Outstanding Under Our
Equity-Based Plans and Convertible Bond Programs



Our
shareholders at annual general meetings approved the implementation of our German and U.S. equity-based stock option plans and convertible bond programs and the creation of several specific authorized and conditional capitals in amounts sufficient
to service these plans and programs, as follows:



The
shareholders at our annual general meetings may authorize our Management Board to increase our share capital with the consent of our Supervisory Board, within a period of five years by issuing shares for a certain total amount (genehmigtes
Kapitalor authorized capital). Our shareholders may also resolve to create conditional capital; however, they may do so only to issue conversion or subscription rights to holders of convertible bonds, in preparation for a merger
with another company or to issue options to employees and members of the management of our company or of an affiliated company by way of a consent or authorization resolution (bedingtes Kapitalor conditional capital). Any
resolution pertaining to the creation of authorized or conditional capital requires a majority of three-quarters of the share capital represented at the relevant shareholders meeting.



The aggregate nominal amount of the authorized capital created by the
shareholders may not exceed one-half of the share capital existing at the time of registration of the authorized capital with the commercial register. The aggregate nominal amount of the conditional capital created by the shareholders may not exceed
one half of the share capital existing at the time of the annual general meeting adopting such resolution. The aggregate nominal amount of the conditional capital created for the purpose of granting options to employees and members of the management
of our company or of an affiliated company may not exceed ten percent of the share capital existing at the time of the annual general meeting adopting the resolution.



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The following table shows the number of our ordinary shares reserved for issuance under our various
German and U.S. equity-based stock option plans and convertible bond programs out of various authorized and conditional capitals, as well as the number of options and convertible bonds granted and outstanding:



|                         |  |                |  |            |  |           |  |                    |  |                             |  |                 
|------------------------ |  | -------------- |  | ---------- |  | --------- |  | ------------------ |  | --------------------------- |  | ----------------
|                         |  | SharesReserved |  | Granted(1) |  | Exercised |  | OutstandingOptions |  | OutstandingConvertibleBonds |  | TotalOutstanding
|Conditional Capital 1997 |  | 1,888,000      |  | 1,887,810  |  | 1,754,107 |  | 133,703            |  |                            |  | 133,703         
|Conditional Capital 2000 |  | 49,000         |  | 44,600     |  | 900       |  | 43,700             |  |                            |  | 43,700          
|Authorized Capital 1999  |  | 785,200        |  | 708,330    |  | 465,830   |  | 242,500            |  |                            |  | 242,500         
|Authorized Capital 2000  |  | 1,880,245      |  | 1,583,217  |  | 773,542   |  | 809,675            |  |                            |  | 809,675         
|Conditional Capital 2001 |  | 740,000        |  | 713,071    |  | 403,061   |  | 310,010            |  |                            |  | 310,010         
|Conditional Capital 2002 |  | 1,310,000      |  | 1,269,475  |  | 983,710   |  | 200,650            |  | 85,115                      |  | 285,765         
|Conditional Capital 2003 |  | 321,500        |  | 292,973    |  | 129,743   |  |                   |  | 163,230                     |  | 163,230         
|Conditional Capital 2004 |  | 1,800,000      |  | 1,646,350  |  | 142,625   |  | 672,475            |  | 831,250                     |  | 1,503,725       
|Conditional Capital 2005 |  | 1,125,000      |  | 1,049,325  |  |          |  | 219,575            |  | 829,750                     |  | 1,049,325       
|Conditional Capital 2006 |  | 1,315,000      |  | 1,019,400  |  |          |  | 224,400            |  | 795,000                     |  | 1,019,400       
|Conditional Capital 2007 |  | 2,850,000      |  | 661,000    |  |          |  |                   |  | 661,000                     |  | 661,000         
|                         |  |                |  |            |  |           |  |                    |  |                             |  |                 
|                         |  | 14,063,945     |  | 10,875,551 |  | 4,653,518 |  | 2,856,688          |  | 3,365,345                   |  | 6,222,033       
|                         |  |                |  |            |  |           |  |                    |  |                             |  |                 



|(1) | Net of cancellations.
|--- | ---------------------



We may continue to issue stock options under each of the 2007, 2006, 2005, 2004, 2002, and 2001 German and U.S. Equity-Based Plans. No additional grants will be
made under the 1999 Incentive Stock Option Plan and the 1999 and 1997 Stock Option Plans. Furthermore, no additional grants will be made under the 2001 and 2002 convertible bond programs.



Employees



As of December 31, 2007, we had 158 employees worldwide, compared to 245 as of December 31, 2006, a decrease of 35.5%. As of December 31, 2007, 62%
of our employees were based in Munich, Germany and 38% were based in our Princeton, New Jersey facility. Of our 158 employees at December 31, 2007, 97 were engaged in research and development activities and 61 were involved in general
administration. We implemented various rounds of restructurings, which involved staff reduction in May 2007, August and November 2007. The numbers above reflect the actual number of people employed with GPC Biotech AG and GPC Biotech Inc. as at
December 31, 2007 and therefore does contain those employees who have been provided notice but whose actual date of termination is after December 31, 2007.



We announced an additional corporate restructuring in February 2008, to sharpen our focus on oncology clinical development efforts and
to further reduce costs. The restructuring was mainly focused on our early-stage research activities in Munich. The combined restructuring activities in 2007 and February 2008 resulted in a reduction of approximately 71% of the total workforce
consisting of approximately 336 employees.



The following tables show the
breakdown of the total year-end and average numbers of our workforce by main category of activity and geographic area for the past three years.



None of our employees are covered by labor unions or covered by a collective bargaining agreement, nor have we experienced any work stoppages at our sites in the
past. We believe that we have good relations with our employees. We draw on a pool of consultants from time to time for advice on certain matters in which we have not developed internal expertise.



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|                                                |  |                       |  |                         |  |      
|----------------------------------------------- |  | --------------------- |  | ----------------------- |  | -----
|As of December 31, 2007                         |  | Research &Development |  | General &Administrative |  | Total
|Germany                                         |  | 71                    |  | 27                      |  | 98   
|United States                                   |  | 26                    |  | 34                      |  | 60   
|                                                |  |                       | 
|As of December 31, 2006                         |  |                       |  |                         |  |      
|Germany                                         |  | 94                    |  | 27                      |  | 121  
|United States                                   |  | 84                    |  | 40                      |  | 124  
|                                                |  |                       | 
|As of December 31, 2005                         |  |                       |  |                         |  |      
|Germany                                         |  | 92                    |  | 24                      |  | 116  
|United States                                   |  | 78                    |  | 28                      |  | 106  
|                                                |  |                       | 
|Average during the year ended December 31, 2007 |  |                       |  |                         |  |      
|Germany                                         |  | 88                    |  | 28                      |  | 116  
|United States                                   |  | 61                    |  | 62                      |  | 123  
|                                                |  |                       | 
|Average during the year ended December 31, 2006 |  |                       |  |                         |  |      
|Germany                                         |  | 92                    |  | 27                      |  | 119  
|United States                                   |  | 80                    |  | 33                      |  | 113  
|                                                |  |                       | 
|Average during the year ended December 31, 2005 |  |                       |  |                         |  |      
|Germany                                         |  | 92                    |  | 25                      |  | 117  
|United States                                   |  | 75                    |  | 26                      |  | 101  



Share Ownership by Members of Our Supervisory
Board and Management Board



Supervisory Board



The following table provides information with respect to
ownership of our ordinary bearer shares, options and convertible bonds for each of our members of the Supervisory Board as of December 31, 2007, based on an aggregate of 36,836,853 shares outstanding.



|                          |  |         |  |                       |  |                               |  |                   |  |               
|------------------------- |  | ------- |  | --------------------- |  | ----------------------------- |  | ----------------- |  | --------------
|Name                      |  | Shares  |  | % ofOutstandingShares |  | Options orConvertible Bonds** |  | ExercisePrice () |  | ExpirationDate
|Jürgen Drews, M.D., Ph.D. |  | 26,900  |  | *                     |  | 12,500 convertible bonds      |  | 5.77              |  | 05/30/2008    
|                          |  |         |  |                       |  | 10,000 options                |  | 17.89             |  | 05/04/2010    
|Michael Lytton, J.D.      |  | 7,500   |  | *                     |  | 31,500 convertible bonds      |  | 5.77              |  | 05/30/2008    
|                          |  |         |  |                       |  | 10,000 options                |  | 16.38             |  | 03/13/2011    
|Metin Colpan, Ph.D.       |  | 19,400  |  | *                     |  | 10,000 convertible bonds      |  | 5.77              |  | 05/30/2008    
|                          |  |         |  |                       |  | 10,000 options                |  | 17.89             |  | 05/04/2010    
|James Frates              |  | 1,000   |  | *                     |  |                              |  |                  |  |              
|Peter Preuss              |  | 87,500  |  | *                     |  | 22,500 convertible bonds      |  | 5.77              |  | 05/30/2008    
|Donald Soltysiak          |  |        |  |                      |  |                               |  |                   |  |               
|                          |  |         |  |                       |  |                               |  |                   |  |               
|Total                     |  | 142,300 |  | *                     |  | 76,500 convertible bonds      |  |                   |  |               
|                          |  |         |  |                       |  | 30,000 options                |  |                   |  |               



|* | Less than one percent of class.
|- | -------------------------------

|** | Each option and bond is exercisable for one ordinary bearer share.
|-- | ------------------------------------------------------------------



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Management Board



The following table provides information with respect to ownership of our ordinary bearer shares, options and convertible bonds for
each of our members of the Management Board as of December 31, 2007, based on an aggregate of 36,836,853 shares outstanding.



|                                   |  |         |  |                       |  |                              |  |                   |  |                   
|---------------------------------- |  | ------- |  | --------------------- |  | ---------------------------- |  | ----------------- |  | ------------------
|Name                               |  | Shares  |  | % ofOutstandingShares |  | Options or Convertible Bonds |  | ExercisePrice () |  | Final ExerciseDate
|Bernd R. Seizinger, M.D., Ph.D.(1) |  | 111,499 |  | *                     |  | 99,000 options               |  | 6.62              |  | 3/31/2010         
|                                   |  |         |  |                       |  | 300,000 options              |  | 17.89             |  | 5/04/2010         
|                                   |  |         |  |                       |  | 90,000 options               |  | 9.69              |  | 8/31/2011         
|                                   |  |         |  |                       |  | 32,250 convertible bonds     |  | 4.36              |  | 8/31/2012         
|                                   |  |         |  |                       |  | 14,194 convertible bonds     |  | 4.87              |  | 5/20/2013         
|                                   |  |         |  |                       |  | 42,057 convertible bonds     |  | 4.96              |  | 5/21/2013         
|                                   |  |         |  |                       |  | 400,000 convertible bonds    |  | 10.90             |  | 9/30/2014         
|                                   |  |         |  |                       |  | 300,000 options              |  | 9.33              |  | 8/31/2014         
|                                   |  |         |  |                       |  | 170,000 convertible bonds    |  | 10.38             |  | 9/30/2015         
|                                   |  |         |  |                       |  | 260,000 convertible bonds    |  | 16.03             |  | 10/31/2016        
|                                   |  |         |  |                       |  | 495,000 convertible bonds    |  | 21.30             |  | 5/31/2017         
|Elmar Maier, Ph.D.(2)              |  | 170,000 |  | *                     |  | 70,000 options               |  | 17.89             |  | 5/04/2010         
|                                   |  |         |  |                       |  | 45,000 convertible bonds     |  | 10.90             |  | 9/30/2014         
|                                   |  |         |  |                       |  | 25,000 options               |  | 9.33              |  | 8/31/2014         
|                                   |  |         |  |                       |  | 100,000 convertible bonds    |  | 10.38             |  | 9/30/2015         
|                                   |  |         |  |                       |  | 130,000 convertible bonds    |  | 16.03             |  | 10/31/2016        
|                                   |  |         |  |                       |  | 83,000 convertible bonds     |  | 21.30             |  | 5/31/2017         
|Sebastian Meier-Ewert, Ph.D.(3)    |  | 194,405 |  | *                     |  | 69,000 options               |  | 6.62              |  | 3/31/2010         
|                                   |  |         |  |                       |  | 70,000 options               |  | 17.89             |  | 5/04/2010         
|                                   |  |         |  |                       |  | 8,505 convertible bonds      |  | 4.96              |  | 5/21/2013         
|                                   |  |         |  |                       |  | 2,870 convertible bonds      |  | 4.87              |  | 5/20/2013         
|                                   |  |         |  |                       |  | 100,000 convertible bonds    |  | 10.90             |  | 9/30/2014         
|                                   |  |         |  |                       |  | 50,000 options               |  | 9.33              |  | 8/31/2014         
|                                   |  |         |  |                       |  | 100,000 convertible bonds    |  | 10.38             |  | 9/30/2015         
|                                   |  |         |  |                       |  | 130,000 convertible bonds    |  | 16.03             |  | 10/31/2016        
|                                   |  |         |  |                       |  | 83,000 convertible bonds     |  | 21.30             |  | 5/31/2017         
|Mirko Scherer, Ph.D.(4)            |  | 7,776   |  | *                     |  | 90,000 options               |  | 17.89             |  | 12/04/2010        
|                                   |  |         |  |                       |  | 50,000 options               |  | 13.34             |  | 12/04/2010        
|                                   |  |         |  |                       |  | 75,000 convertible bonds     |  | 9.33              |  | 3/31/2008         
|                                   |  |         |  |                       |  | 50,000 options               |  | 9.33              |  | 12/04/2010        
|                                   |  |         |  |                       |  | 50,000 convertible bonds     |  | 10.38             |  | 3/31/2008         
|                                   |  |         |  |                       |  | 32,500 convertible bonds     |  | 16.03             |  | 3/31/2008         
|                                   |  |         |  |                       |  |                              |  |                   |  |                   
|Total                              |  | 483,680 |  | 1.31                  |  | 1,263,000 options            |  |                   |  |                   
|                                   |  |         |  |                       |  | 2,353,376 convertible bonds  |  |                   |  |                   



|* | Less than one percent of class.
|- | -------------------------------

|(1) | During 2007, Dr. Seizinger exercised and sold a total of 159,840 options under his arrangements with a third-party financial
institution and exercised 49,999 convertible bonds.
|--- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(2) | During 2007, Dr. Maier exercised and sold 48,000 options and 146,000 convertible bonds.
|--- | ---------------------------------------------------------------------------------------

|(3) | During 2007, Dr. Meier-Ewert exercised and sold 12,500 options and 46,764 convertible bonds.
|--- | --------------------------------------------------------------------------------------------

|(4) | During 2007, Dr. Scherer exercised and sold 75,000 options and exercised and sold 71,000 convertible bonds. Dr. Scherer
resigned on December 4, 2007. The above status is in accordance with the severance agreement agreed upon his resignation.
|--- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



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Marketplace Rules Exemptions Granted by Nasdaq



In 2004, in connection with our listing of American Depository Shares representing our ordinary shares on Nasdaq, Nasdaq granted us two exemptions
with respect its Marketplace Rules.



Quorum



Nasdaq granted us an exemption with respect to Marketplace Rule 4350(f), which requires
issuers by-laws to establish a minimum quorum of 33 1/3 % for any meeting of the holders of common stock. Neither German law nor the rules and regulations promulgated by the Frankfurt Stock Exchange, the primary market for our shares,
require a specific quorum for annual general meetings; therefore, our Articles of Association do not provide for a quorum. The absence of a quorum requirement in the Companys Articles of Association is consistent with German law and such a
requirement would be contrary to generally accepted business practice in Germany.



Shareholder Approval of Stock Option Plans



Nasdaq
granted us an exemption with respect to Marketplace Rule 4350(i)(1)(A), which requires issuers to obtain shareholder approval prior to the establishment or material amendment to certain stock option or purchase plans. The exact terms and conditions
of our equity compensation plans are not the subject of a shareholder vote at the annual general meeting. Instead, our shareholders only vote on the creation of underlying capital to service the equity awards and certain other general terms
prescribed by German law and authorize the Management Board or, in respect of awards to be made to the members of our Management Board, the Supervisory Board, to determine the details of our equity compensation plans. It is intended that all such
plans be established within any policies and programs approved by the Compensation Committee.



Item 7. Major Shareholders and Related Party Transactions



Major Shareholders



The following table sets
forth certain information regarding the ownership of our share capital of our principal shareholders who hold more than five percent (5%) of our voting rights. Ownership of the stock and voting rights are disclosed as of December 31, 2007
or as of such later date indicated below, according to the information available to us on the basis of notifications according to the German Securities Trading Act (WertpapierhandelsgesetzWpHG), and, where indicated, based on Schedules
13G filed with the SEC.



As of December 31, 2007, a total 36,836,853
shares were outstanding, with 36,836,853 voting rights. The voting rights of our principal shareholders do not differ from the voting rights of any other shareholders.



|                |  |                 |  |                   |   |  |                  |  
|--------------- |  | --------------- |  | ----------------- | - |  | ---------------- | -
|Shareholder     |  | Numberof shares |  | % of sharecapital |   |  | % ofvotingrights |  
|Dietmar Hopp(1) |  | 6,300,561       |  | 17.10             | % |  | 17.10            | %
|DIT(2)          |  | 1,889,855       |  | 5.72              | % |  | 5.72             | %



|(1) | Information as of December 21, 2007 pursuant to a Schedule 13G filed with the SEC on that date. These shares attributed to
Dietmar Hopp are also beneficially owned by Golf-Club St. Leon-Rot Betriebsgesellschaft mbH & Co. KG and Verwaltungsgesellschaft des Golf-Club St. Leon-Rot mbH, in each case comprised of 3,440,561 voting shares (or 9.3%) registered in
the name of Golf-Club St. Leon-Rot Betriebsgesellschaft mbH & Co. KG and 2,860,000 voting shares (or 7.8%) registered in the name of dievini Hopp Biotech GmbH & Co. KG. The shares
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



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| | registered in the name of dievini Hopp Biotech GmbH & Co. KG are also beneficially owned by Oliver Hopp, DH-Capital GmbH & Co. KG, OH Beteiligungen
GmbH & Co. KG, OH-Capital GmbH & Co. KG, dievini Verwaltungs GmbH, Prof. Dr. Christof Hettich, Dr. Friedrich von Bohlen und Halbach, Berthold Wipfler and BW Verwaltungs GmbH.
| | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(2) | Information by Deutsche Investment-Trust Gesellschaft für Wertpapieranlagen mbH (DIT) as of September 29, 2006 according
to a notification received in accordance with Sec. 26 (1) WpHG. After such date, we have received no further notifications from DIT.
|--- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



To the knowledge of our management, no other shareholder owns directly or indirectly more than five percent of our equity or voting rights. As of December 31,
2007, the aggregate amount of our shares owned by current Management Board and Supervisory Board members amounts to approximately 1.7% of our outstanding share capital.



Under German law, shareholders in a public company are required to notify the company and the German Federal Financial Supervisory Authority
(Bundesanstalt für Finanzdienstleistungsaufsicht) of the number of shares they own when their percentage ownership reaches, exceed or falls below certain threshold levels, described in greater detail below in Item 10. Additional
InformationNotification and Disclosure Obligations . German law does not require a shareholder to update this information unless it again reaches, exceeds or falls below a notification threshold. As a result, we cannot be certain whether
the number of shares owned by the shareholders listed above is accurate.



In addition, our shares are bearer shares and as a result we cannot reliably estimate the portion of our ordinary shares held in Germany or the number of record holders in Germany.



Changes in Principal Shareholders During the Past Three Fiscal Years



On March 15, 2006, DWS Investment GmbH notified GPC Biotech that its shareholdings
amounted to 4.87% of GPC Biotechs voting shares as of March 7, 2006. DWS Investment GmbH is one of the subsidiaries of Deutsche Bank AG whose aggregate shareholdings as of December 31, 2005 (based on a Schedule 13G filed on
March 14, 2006) amounted to 8.45% of GPC Biotechs voting shares. Taking into consideration the reduction in DWS Investment GmbHs shareholdings, the total shareholdings attributed to Deutsche Bank AG as of March 7, 2006 amounted
to 5.53% of GPC Biotechs voting shares.



On April 3 and
April 21, 2007 Dietmar Hopp, Oliver Hopp, DH Capital GmbH & Co. KG, OH Beteiligungen GmbH & Co. KG, BW Verwaltungs GmbH and Bertold Wipfler each notified GPC Biotech that their respective shareholdings amounted to 8.66% of the
GPC Biotechs voting shares as of March 23, 2006. Each of the individuals and entities referenced is deemed to own the holdings of the others, so that the total share ownership does not exceed 8.66%.



On July 20, 2006, Deutsche Investment-Trust Gesellschaft für
Wertpapieranlagen mbH informed us that as of that date, its shareholdings fell below 5% of GPC Biotechs then-outstanding voting shares and amounted to 4.06%.



On October 4, 2006, Deutsche Investment-Trust Gesellschaft für Wertpapieranlagen mbH informed us that as of
September 29, 2006 their shareholdings exceeded the threshold of 5% and amounted to 5.72% in public funds (or 1,889,855 shares).



On October 20, 2006, Susanne Klatten and Altana AG informed us, that as of September 29, 2006 they no longer held shares in GPC Biotech.



On January 24, 2007, GPC Biotech raised gross proceeds of  33.6 million (approximately $43.7 million) in a private placement with institutional investors by selling 1,564,587 million shares at a price of  21.50 per share.



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In connection with the January 24, 2007 private placement, DH Capital GmbH & Co. KG and OH
Beteiligungen GmbH & Co. KG, the entities affiliated with Mr. Dietmar Hopp, provided a loan of GPC Biotech shares to the underwriters. As a result of the loan (pursuant to the disclosure requirements under the German Securities Trading
Act), Dietmar Hopp, notified GPC Biotech on January 24, 2007 that his shareholdings amounted to 6.67% as of January 24, 2007 and Oliver Hopp, DH Capital GmbH & Co. KG, OH Beteiligungen GmbH & Co. KG, BW Verwaltungs GmbH
and Bertold Wipfler each notified GPC Biotech that their respective shareholdings amounted to 3.79% of GPC Biotechs voting shares as of January 24, 2007. Each of the individuals and entities referenced in the immediately preceding
sentence is deemed to own the holdings of the others, so that the total share ownership does not exceed 3.79% and Mr. Dietmar Hopp is deemed to own the 3.79% held by these individuals and entities in addition to another 2.88% he directly owns.



On February 5, 2007, Roland Oetker and ROI Verwaltungsgesellschaft
mbH informed us that as of that date, their shareholdings fell below 5% of GPC Biotechs then-outstanding voting shares and amounted to 4.64% (or 1,660,645 shares).



On February 22, 2007, Allianz Global Investors Kapitalanlagegesellschaft informed us that as of that date, their shareholdings fell below 5% of
GPC Biotechs then-outstanding voting shares and amounted to 4.74% (or 1,622,966 shares).



On May 4, 2007, Deutsche Bank AG informed us that as of April 26, 2007, the shareholdings of their subsidiary, DWS Investment GmbH, exceeded 5% of GPC Biotechs then-outstanding voting shares and amounted to
5.01% (or 1.804.450 shares).



On May 21, 2007, Deutsche Bank AG
informed us that as of May 15, 2007, the shareholdings of their subsidiary, DWS Investment GmbH, fell below 5% of GPC Biotechs then-outstanding voting shares and amounted to 4.99% (or 1.799.710 shares).



On June 1, 2007, Deutsche Bank AG informed us that as of May 28, 2007, the
shareholdings of their subsidiary, DWS Investment GmbH, exceeded 5% of GPC Biotechs then-outstanding voting shares and amounted to 5.39% (or 1.947.850 shares).



On July 25, 2007, Mr. Roland Oetker informed us that as of that date, his and the shareholdings fell below 3% of GPC
Biotechs then-outstanding voting shares and amounted to 2.55% (or 924.531 shares). He also provided the same notification with respect to ROI Verwaltungsgesellschaft mbH, whose shares are attributed to him.



On July 26, 2007, Deutsche Bank AG informed us that as of July 24, 2007, the
shareholdings of their subsidiary, DWS Investment GmbH, fell below 5% of GPC Biotechs then-outstanding voting shares and amounted to 4.11% (or 1.491.600 shares).



On July 30, 2007 Deutsche Bank AG informed us that as of July 27, 2007, the shareholdings of their subsidiary, DWS Investment GmbH, fell
below 3% of GPC Biotechs then-outstanding voting shares and amounted to 2.66% (or 966.678 shares).



Related Party Transactions



We have, from
time to time, entered into agreements with our shareholders and affiliates. We describe the principal transactions entered into since 2005 below.



In November 2001, we formed a strategic alliance with ALTANA Pharma AG in connection with the establishment by ALTANA Pharma of the ALTANA Research Institute,
ALTANA Pharmas U.S. research operation based in Waltham, Massachusetts. This alliance encompasses a technology transfer component as well as research collaboration. Pursuant to the agreement with ALTANA



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Pharma, we were assisting ALTANA Pharma with the ALTANA Research Institute through the transfer of certain of our genomic and proteomic technologies to the ALTANA
Research Institute. Effective January 2003, we entered into another collaboration agreement with ALTANA Pharma pursuant to which we licensed LeadCode to ALTANA Pharma. We were entitled to receive a total of $60 million in payments from ALTANA
Pharma, including upfront payments, license and technology transfer fees, and research funding under these agreements. Under each of these agreements, ALTANA Pharma is also obligated to make certain milestone payments totaling approximately $15
million (subject to reduction in certain circumstances) to us in connection with the development and commercialization of each product resulting from the research collaborations. However, committed revenues from the collaboration and license
agreement and the LeadCode agreement with ALTANA Pharma decreased substantially as the collaboration terms of those agreements approach their expiration in mid-2007. In the past, ALTANA Pharma was our largest customer, accounting for approximately
97% of our total revenues in 2005, 99% of our total revenues in 2004, and 94% of our total revenues in 2003. In addition, Dr. Seizinger, our President and Chief Executive Officer, was a member of the Supervisory Board of ALTANA Pharma AG, which
is a subsidiary of ALTANA AG, until December 31, 2006.



Dr. Drews, the Chairman of our Supervisory Board, is also the Vice Chairman of the supervisory board of MorphoSys AG. Additionally, Dr. Metin Colpan, a member of our Supervisory Board, is also a member of the supervisory board of
MorphoSys AG. In April 1999, we entered into a collaboration and license agreement with MorphoSys. Since the initiation of the collaboration, MorphoSys has identified more than a dozen antibodies, from which we selected our product candidate known
as 1D09C3. MorphoSys is entitled to milestone payments upon the occurrence of specified events in the development and commercialization of antibody product candidates resulting from the collaboration. If all milestones were achieved, these milestone
payments would total approximately 10 million. MorphoSys is also entitled to receive royalties on net sales of any of these antibody products by us. If we enter
into an agreement with a partner for the commercialization of any of these antibody products, we would be obligated to pay MorphoSys a percentage of sublicense fees, milestone payments and royalties.



Mr. Preuss, a member of our Supervisory Board, is also a Regent of the University
of California. In February 2004, we entered into a research agreement with The Regents of the University of California as sponsor of a research project entitled Characterization of JM-118 Resistance.



Don Soltysiak, a member of our supervisory board entered into a consulting agreement
with GPC Biotech, Inc., the Companys wholly-owned subsidiary, according to which he provided consulting services for GPC Biotech, Inc. in the field of Sales in Oncology and was obligated to inform the company in the event any
information, results, technology or product opportunities arise in the field. Under the agreement, Mr. Soltysiak was entitled to receive $3,000 per day (excluding expenses) for his services which are generally expected to require about 20 days
per year and are not to exceed 25 days per year without written permission of the company. The consulting agreement expired in July 2007 in accordance with its term and has not been renewed. During his tenure as a Mr. Soltysiak primarily
assisted the company by suggesting and interviewing candidates for GPC Biotechs sales and marketing organization (primarily sales representatives) and has provided input and feedback on marketing strategies developed by GPC Biotech. Our
Supervisory Board reviewed and approved the terms of his consulting agreement, in accordance with the requirements of German law.



Loans Extended and Guarantees Provided



No loans or guarantees have been provided to the members of our Management Board or the members of the Supervisory Board for the last three years.



Item 7 C. Interests of Experts and Counsel.



Not applicable.



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Item 8. Financial Information



CONSOLIDATED FINANCIAL STATEMENTS



Please refer to Item 18. Financial Statements



Legal Proceedings



In December 2006, we were notified by Spectrum Pharmaceuticals that Spectrum had initiated an arbitration proceeding with the American Arbitration Association in the United States to resolve a dispute between Spectrum and GPC
Biotech under the co-development and license agreement for satraplatin. On November 9, 2007 a three-arbitrator panel of the American Arbitration Association issued its decision in favor of GPC Biotech and unanimously rejected all of
Spectrums claims and found no violations of the agreement by GPC Biotech.



In July 2007, we and certain of our current and former officers were sued in the United States District Court for the Southern District of New York in three separate securities fraud class action lawsuits on behalf of all persons who
purchased the securities of GPC Biotech between December 5, 2005 and July 24, 2007, inclusive. The suits have since been consolidated and a lead plaintiff has been appointed. The lead plaintiffs consolidated complaint was filed on
March 12, 2008. The consolidated complaint alleges that GPC Biotech violated U.S. federal securities laws by making misleading public statements relating to the prospects of its most advanced product candidate, satraplatin, and thereby
artificially inflating the price of GPC Biotech securities. The consolidated complaint also names Bernd R. Seizinger (CEO) and three former members of our Management Board, Mirko Scherer, Elmar Maier, and Sebastian Meier-Ewert, as defendants. We
filed a motion to dismiss the consolidated complaint on May 14, 2008. The plaintiff has the opportunity to file an opposition to the motion to dismiss on or before June 30, 2008. If the plaintiff files such an opposition, we will then have
the opportunity to reply thereto on or before August 8, 2008.



We
are not currently engaged in any other material legal proceedings.



Dividend Policy
and Liquidation Process



We have never paid any dividends on our
ordinary bearer shares. Under German corporate law, we currently have no ability to pay dividends because of our past losses. We do not expect to have any annual net income in the foreseeable future. If we were to earn annual net income, we
currently plan to retain such annual net income for the foreseeable future to finance business development and internal growth. We therefore do not anticipate paying dividends in the foreseeable future.



Under German law, GPC Biotech may pay dividends only from retained earnings(Bilanzgewinn)reflected in its unconsolidated financial statements (as opposed to the consolidated financial statements for GPC Biotech and its subsidiary) prepared in accordance with the principles set forth in the German Commercial Code
(Handelsgesetzbuch) and as adopted and approved by the Management Board and the Supervisory Board. In determining the retained earnings that may be distributed as dividends, under German law, the Management Board may allocate to earnings
reserves (Gewinnrücklagen) up to 50% of GPC Biotechs remaining net income for the fiscal year after deducting amounts to be allocated to legal and statutory reserves and losses carried forward. The Management Board may also
increase retained earnings when preparing the financial statements with funds withdrawn from earnings reserves.



Our shareholders, in their resolution on the appropriation of retained earnings, may carry forward distributable retained earnings in part or in full and may
allocate additional amounts to earnings reserves.



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Profits carried forward will be automatically incorporated in the retained earnings of the next fiscal year. Amounts allocated to the earnings reserves are available
for dividends only if and to the extent the earnings reserves have been dissolved by the Management Board when preparing the financial statements, thereby increasing the retained earnings.



Our shareholders may declare dividends at an ordinary general shareholders
meeting, which must be held within the first eight months of each fiscal year. Dividends approved at an ordinary general shareholders meeting are payable promptly after the meeting, unless otherwise decided at the meeting. Because all of our
shares are in book-entry form represented by one or more global certificates deposited with Clearstream Banking AG in Frankfurt am Main, Germany, shareholders would receive dividends through Clearstream Frankfurt for credit to their deposit
accounts.



Apart from liquidation as a result of insolvency proceedings,
GPC Biotech may be liquidated only with a majority of three-quarters of the share capital present or represented at a shareholders meeting at which the vote is taken. In accordance with the German Stock Corporation Act (Aktiengesetz),
upon a liquidation of GPC Biotech, any liquidation proceeds remaining after paying off all of GPC Biotechs liabilities would be distributed among the shareholders in proportion to the number of shares held by each shareholder. Dividends are
subject to German withholding tax. See German TaxationWithholding Tax.



Form, Certification and Transferability of the Shares



The form and contents of our share certificates, dividend and renewal coupons are determined by our Management Board with the consent of our Supervisory Board. We may combine individual shares into share certificates that represent multiple
shares (global shares, global certificates). Shareholders have no right to receive individual share certificates and all shares are represented by one or more global bearer share certificates.



All of our outstanding shares are bearer shares. If a resolution regarding a capital
increase does not specify whether such increase will be in bearer or registered form, the new shares resulting from such capital increase will be bearer shares by default. Any resolution regarding a capital increase may determine the profit
participation of the new shares resulting from such capital increase in deviation from § 60(2)(3) of the German Stock Corporation Act.



Our shares are freely transferable, with the transfer of ownership governed by the German Civil Code (Buergerliches Gesetzbuch) and the rules of the relevant
clearing system.



Significant Changes



Effective January 1, 2008, the Company appointed Torsten Hombeck, Ph.D. to Chief
Financial Officer. Dr. Hombeck joined GPC Biotech in 1999. He has worked out of the Companys U.S. offices as Vice President, Finance since 2002 and continues to be based in Princeton, New Jersey. Prior to joining GPC Biotech, he held
positions in corporate finance and controlling, including financial oversight responsibility for South America, at Beiersdorf AG, an international branded consumer products company. Dr. Hombeck holds a Masters degree in business administration
as well as a Ph.D. in Finance from the European Business School, Oestrich-Winkel, Germany.



In February 2008, the Company announced a corporate restructuring to sharpen the Companys focus on oncology clinical development efforts and to further reduce costs. The restructuring was mainly focused on the
Companys early-stage research activities in Munich and will result in a reduction in the total workforce of approximately 38% or 38 employees.



Also in February 2008, the Company announced that, by mutual consent, Elmar Maier, Ph.D., Chief Operating Officer/Martinsried and Senior Vice President, Business
Development, and Sebastian



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Meier-Ewert, Ph.D., Senior Vice President and Chief Scientific Officer left their positions on the Management Board of the Company. Both Dr. Maier and
Dr. Meier-Ewert received severance payments equal to their respective previous annual base salaries. However, in the event that they accept full-time employment or a full-time management position with a third party prior to March 31, 2009
they are only entitled to a pro-rata portion of the severance payment (based on a one-year period) and have to remit the remainder (net) to the Company. Both Dr. Maier and Dr. Meier-Ewert remain dedicated to the Company as advisors under
separate consulting agreements.



In February 2008, the Company also
reported that it had decided to discontinue internal development of its monoclonal antibody, 1D09C3.



Item 9. The Offer and Listing.



Not applicable.



Trading Markets



Our shares are currently traded on the Frankfurt Stock Exchange under the symbol
GPC. Our shares also are traded on Nasdaq under the symbol GPCB.



The table below sets forth, for the periods indicated, the high and low closing prices of our shares and ADSs as reported by the Frankfurt Stock Exchange Xetra trading system and Nasdaq, in euro and U.S. dollars, respectively:



|                         |  |        |  |       |  |       |  |       |  |   |  |      
|------------------------ |  | ------ |  | ----- |  | ----- |  | ----- |  | - |  | -----
|                         |  | NASDAQ |  | XETRA
|Year                     |  | High   |  | $     |  | Low   |  | High  |  |  |  | Low  
|2007                     |  |        |  |       |  |       |  |       |  |   |  |      
|January through March    |  | 32.85  |  |       |  | 24.84 |  | 24.93 |  |   |  | 19.00
|April through June       |  | 32.81  |  |       |  | 26.07 |  | 22.54 |  |   |  | 19.45
|July through September   |  | 31.99  |  |       |  | 10.35 |  | 22.96 |  |   |  | 7.57 
|October through December |  | 12.56  |  |       |  | 3.60  |  | 8.97  |  |   |  | 2.62 
|                         |  |        |  |       |  |      
|Year                     |  |        |  |       |  |       |  |       |  |   |  |      
|2008                     |  |        |  |       |  |       |  |       |  |   |  |      
|January through March    |  | 4.60   |  |       |  | 2.79  |  | 2.89  |  |   |  | 1.69 
|                         |  |        |  |       |  |      
|Month                    |  |        |  |       |  |       |  |       |  |   |  |      
|December 2007            |  | 5.12   |  |       |  | 3.60  |  | 3.59  |  |   |  | 2.71 
|January 2008             |  | 4.17   |  |       |  | 2.79  |  | 2.89  |  |   |  | 1.69 
|February 2008            |  | 4.19   |  |       |  | 3.48  |  | 2.83  |  |   |  | 1.83 
|March 2008               |  | 3.62   |  |       |  | 3.02  |  | 2.89  |  |   |  | 2.21 
|April 2007               |  | 3.38   |  |       |  | 2.55  |  | 2.40  |  |   |  | 2.00 
|May 2007                 |  | 4.60   |  |       |  | 2.67  |  | 2.09  |  |   |  | 1.69 
|                         |  |        |  |       |  |      
|Year                     |  |        |  |       |  |       |  |       |  |   |  |      
|2003                     |  |       |  |       |  |      |  | 9.25  |  |   |  | 2.57 
|2004                     |  | 16.00  |  |       |  | 10.32 |  | 16.36 |  |   |  | 8.07 
|2005                     |  | 15.11  |  |       |  | 10.56 |  | 11.90 |  |   |  | 7.99 
|2006                     |  | 25.50  |  |       |  | 12.95 |  | 19.30 |  |   |  | 10.27
|2007                     |  | 32.85  |  |       |  | 3.60  |  | 24.93 |  |   |  | 2.62 
|                         |  |        |  |       |  |      
|Year                     |  |        |  |       |  |       |  |       |  |   |  |      
|2006                     |  |        |  |       |  |       |  |       |  |   |  |      
|January through March    |  | 18.30  |  |       |  | 12.95 |  | 15.14 |  |   |  | 10.70
|April through June       |  | 16.90  |  |       |  | 13.25 |  | 13.58 |  |   |  | 10.25
|July through September   |  | 19.33  |  |       |  | 13.42 |  | 15.40 |  |   |  | 10.75
|October through December |  | 25.50  |  |       |  | 18.77 |  | 19.30 |  |   |  | 14.79



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On June 26, 2008, the closing price of our shares on the Frankfurt Stock Exchange Xetra trading system was
 2.53 and the closing price of our ADSs on Nasdaq was $ 4.02.



Item 10. Additional Information.



Description of Share Capital



The following description is a summary of certain information relating to our share capital as well as certain provisions of our Articles of Association and
German stock corporation law. This summary does not purport to be complete and speaks only as of the date hereof.



Organization



We are a stock corporation organized in the Federal Republic of Germany under the German Stock Corporation Act (Aktiengesetz). We are registered in the Commercial Register (Handelsregister) maintained by the local
court in Munich, Germany, under the entry number 119555. Copies of our Articles of Association are publicly available from the Commercial Register Munich, and an English translation can be found in Exhibit 1.1 to this Form 20-F.



Share Capital



As of December 31, 2007, our share capital amounted to  36,836,853 and was divided into 36,836,853 no par-value ordinary bearer shares (auf den Inhaber lautende Stückaktien ohne Nennbetrag), each with a notional nominal value (the proportional amount of the share capital
attributable to each share) of 1.



General Information on Capital Measures



Our capital stock may be increased in consideration of contributions in cash or in kind, or by establishing authorized capital or conditional capital or by an
increase of the companys capital reserves. Authorized capital provides our Management Board with the flexibility to issue new shares for a period of up to five years. The Management Board must obtain the approval of the Supervisory Board
before issuing new shares out of the authorized capital and must register the increase in the commercial register and amend its Articles of Association accordingly before the shares are validly issued. Conditional capital allows the issuance of new
shares for specified purposes, including employee stock option plans, convertible bond programs for compensation purposes and the issuance of shares upon conversion of convertible bonds and exercise of options or warrants for financing purposes. In
the case of conditional capital, the shares are validly issued as soon as all the relevant conditions of exercise or conversion are met; no further actions by the Management Board or the Supervisory Board are necessary. Because of the fact that no
immediate changes to the Companys Articles of Association are required in connection with exercises out of conditional capital, the numbers stated in our Articles may not at all times match the exact numbers of shares still available under any
given conditional capital. However, the Company is required under German law to true-up the numbers at least once a year (generally until January 31 for the preceding fiscal year) in the Companys commercial register. The Company also
reports changes to its issued and outstanding shares, if any, monthly on its website in accordance with German law.



By law, the Management Board may only issue new shares with regard to the contingent capital for the specified purposes. Apart from issuance out of Capital
increases require an approval by 75% of the issued shares present at the Annual General Shareholders Meeting at which the increase is proposed and require an amendment to the Articles of Incorporation.



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The aggregate nominal amount of the authorized capital created by the shareholders may not exceed one half of the
share capital existing at the time of registration of the authorized capital with the commercial register.



The aggregate nominal amount of the conditional capital created by the shareholders may not exceed one half of the share capital existing at the time of the annual
general meeting adopting such resolution. The aggregate nominal amount of the conditional capital created for the purpose of granting subscription rights to employees and members of the management of our company or of an affiliated company may not
exceed ten percent of the share capital existing at the time of the annual general meeting adopting the resolution.



Any resolution relating to a reduction of our share capital requires a majority of at least three quarters of the share capital represented at the relevant
shareholders meeting.



Authorizations for Capital Increases
out of Conditional Capital



As of December 31, 2007, our
Management Board was authorized to issue shares out of conditional capitals in connection with option rights pursuant to the Companys stock option and convertible bond programs, as follows:



|                                                       |  |          
|------------------------------------------------------ |  | ---------
|Stock Option Plan 1997                                 |  | 133,893  
|Stock Option Plan 2000                                 |  | 48,100   
|Stock Option Plan 2001                                 |  | 336,939  
|Convertible Bond Program 2001                          |  | 10,000   
|Stock Option Plan 2002                                 |  | 241,175  
|Convertible Bond Program 2002                          |  | 85,115   
|Convertible Bond Program 2003 (Supervisory Board only) |  | 115,027  
|Convertible Bond Program 2003                          |  | 76,730   
|Convertible Bond Program 2004                          |  | 887,500  
|Stock Option Plan 2004                                 |  | 796,875  
|Convertible Bond Program 2005                          |  | 900,000  
|Stock Option Plan 2005                                 |  | 225,000  
|Convertible Bond Program 2006                          |  | 900,000  
|Stock Option Plan 2006                                 |  | 415,000  
|Convertible Bond Program 2007 Management Board only    |  | 1,700,000
|Stock Option Plan 2007 Employees only                  |  | 1,150,000



In addition, out of a
conditional capital pursuant to Sec. 5(4e) of the Articles the Management Board is authorized to issue new shares in connection with conversion- or option rights available to holders of convertible bonds or options pursuant to the authorization
granted in the Annual Shareholder Meeting on June 8, 2005 or if the holders of convertible bonds issued by the Company or its direct or indirect majority-owned subsidiaries until May 31, 2010 fulfill their obligation to convert. 6,000,000
shares remain available under this conditional capital.



Also, out of a
conditional capital pursuant to Sec. 5(4p) of the Articles the Management Board is authorized to issue new shares in connection with conversion or option rights available to holders of convertible bonds or options pursuant to the authorization
granted in the Annual Shareholder Meeting on May 25, 2007. 3,400,000 shares remain available under this conditional capital. In connection therewith, the Management Board is authorized to exclude existing shareholders statutory
subscription rights, subject to the consent of the Supervisory Board, once or several times, in the case of a capital increase against cash contributions, if the issue price is not materially below the stock market price.



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However, such authorization shall only apply to the extent to which the shares issued with exclusion of subscription rights pursuant to Section 186(3)(4) AktG do
not exceed 10% of the share capital at the time when this authorization becomes effective or when it is utilized. The 10% limit shall take into account any shares of the Company issued or sold by the Company in direct or analogous application of
Section 186(3)(4) of the German Stock Corporation Act (AktG) during the duration of this authorization until its full utilization. The Management Board is also authorized to exclude existing shareholders statutory subscription
rights, subject to the consent of the Supervisory Board, once or several times or in order to exclude any fractional amounts from the subscription rights.



Authorizations for Capital Increases out of Authorized Capital



As of December 31, 2007, our Management Board, with the consent of the Supervisory Board, was authorized to issue shares out of
authorized capitals, as follows:



The Management Board is authorized to
increase the Companys share capital until April 30, 2012, with the consent of the Supervisory Board, once or several times, by up to a total of 
11,500,000 through issuance of up to 11,500,000 new no-par-value ordinary bearer shares against cash and/or non-cash contribution (Authorized Capital I/2007). In connection therewith, the Management Board is authorized to exclude
existing shareholders statutory subscription rights, with the consent of the Supervisory Board, once or several times, (i) if the new shares are issued against non-cash contributions; (ii) to use the new share to fulfill the
Companys obligations under warrants or convertible bonds issued or guaranteed pursuant to the authorization of the Management Board in Item 8 of the Annual Shareholders Meeting of May 25. 2007; (iii) for the purpose of
introducing the Companys stock on a foreign stock exchange or increasing its presence on foreign financial markets, and, in this context, also for covering any over-allotment option granted to the underwriting banks; and (iv) in order to
exclude any fractional amounts from the subscription rights.



The
Management Board is further authorized to increase the Companys share capital until April 30, 2012, with the consent of the Supervisory Board, once or several times, by up to a total of  3,500,000 through issuance of up to 3,500,000 new no-par-value ordinary bearer shares against cash contribution (Authorized Capital II/2007). In connection therewith, the
Management Board is authorized to exclude existing shareholders statutory subscription rights, subject to the consent of the Supervisory Board, once or several times, in the case of a capital increase against cash contributions, if the issue
price is not materially below the stock market price. However, such authorization shall only apply to the extent to which the shares issued with exclusion of subscription rights pursuant to Section 186(3)(4) AktG do not exceed 10% of the share
capital at the time when this authorization becomes effective or when it is utilized. The 10% limit shall take into account any shares of the Company issued or sold by the Company in direct or analogous application of Section 186(3)(4) of the
German Stock Corporation Act (AktG) during the duration of this authorization until its full utilization. The Management Board is also authorized to exclude existing shareholders statutory subscription rights, subject to the consent of
the Supervisory Board, once or several times or in order to exclude any fractional amounts from the subscription rights.



The Management Board is further authorized to increase the Companys share capital by up to  1,151,943 by August 31, 2009 though issuance, once or several times, of up to 1,151,943 new no-par-value ordinary bearer shares against cash contribution (Authorized Capital I/2004). In connection
therewith, the Management Board is authorized, subject to consent by the Supervisory Board, to exclude existing shareholders statutory subscription rights once or several times (i) if necessary to guarantee subscription rights to
beneficial owners of stock options that were issued on the basis of shareholders authorizations of the General Meetings of May 12, 1999 (Agenda Item 8) and May 3, 2000 (Agenda Item 10.1) to members of the Management Board,
members of the general management of subsidiaries, employees of the company and consultants; and (ii) if necessary to



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guarantee subscription rights to holders of options and warrants of the former Mitotix, Inc. as well as to former shareholders of Mitotix, Inc., on the basis of the
shareholders authorization of the Extraordinary General Meeting of March 3, 2000 (Agenda Item 3).



More information regarding our authorized and conditional capitals is included in
Note             in Item 18. Financial Statements.



Authorization to acquire Treasury Shares



At the Annual Shareholder Meeting on May 25, 2007, GPC Biotech was authorized to acquire treasury shares up to a total of 10% of the share capital existing at
the time when the resolution is passed. At no time shall the total of the acquired shares and the other treasury shares owned by the Company or allocable to it pursuant to Sections 71a et seq. of the German Stock Corporation Act constitute more than
10% of the share capital. The authorization may not be used by the Company for the purpose of trading in treasury shares.



The authorization may be utilized in full or in partial amounts by the Company or its affiliated subsidiary companies or by third parties for the Companys or
any group companys account, once or several times, in order to pursue one or several purposes. The authorization is valid until November 24, 2008. The Management Board has the right to choose whether treasury shares shall be acquired via
the stock market or by means of a public offer hereafter. In the case of acquisition of the shares via the stock exchange, the amount per share paid by the Company (excluding ancillary acquisition costs) may not exceed or be less than the price
determined in the XETRA opening auction (or that of a comparable successor system) on the trading day by more than 5%. In the case of acquisition through a public offer to all shareholders, (i) an offer submitted by the Company may be published
or (ii) the shareholders may be asked publicly to submit offers. The rules of the German Securities Acquisition and Takeover Act must be complied with only if and to the extent to which this law is applicable to such acquisitions by the
Company. In both cases, the purchase price offered or the limits of the purchase range offered per share (excluding ancillary acquisition costs) must not exceed or be less than the relevant price of a share of the Company by more than 10%. The
relevant price in scenario (i) is the price determined in the XETRA closing auction on the exchange trading day prior to announcement of the offer, and in scenario (ii) the price determined in the XETRA closing auction on the last exchange
trading day prior to the day on which the offers are accepted by the Company. If considerable variations in the relevant price arise in scenario (i) after publication of the formal offer, the offer may be adjusted; in this case, the
corresponding price on the last exchange trading day before publication of the adjustment shall be authoritative.



The offer or request for submission of offers may provide for further conditions and for the possibility of specifying the purchase price or purchase price range
during the offer period. If the offer or request for submission of offers is oversubscribedunder identical terms and conditionsacceptance must be proportional to the shares offered. Arrangements can be made to allow for privileged
acceptance of small batches up to 100 shares offered per shareholder. The Management Board is authorized to use the Companys shares acquired on the basis of this authorization as follows:



| | (1) | They may be cancelled, without such cancellation or its implementation requiring further resolutions by the Shareholders Meeting. Authorization of cancellation may be exercised in full or in
part. In deviation of the above, the Management Board may decide that the shares shall be cancelled in a simplified procedure without capital reduction through adjustment of the pro-rata imputed amount of the other no-par-value shares in the
Companys share capital. The authorization to cancel shares may be utilized repeatedly. In the event of cancellation on the basis of the simplified procedure, the Management Board shall be authorized to adjust the number of shares cited in the
articles of association.
| | --- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



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| | (2) | The shares may also be sold to shareholders other than via the stock exchange or an offer to shareholders, if they are sold against cash payment at a price not materially below the stock
exchange quotation for shares of the Company with the same rights and preferences at the time of their sale.
| | --- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (3) | They may be offered and transferred to third partiesalso against non-cash contributionwithin the context of mergers or acquisitions of businesses or equity participations in
companies.
| | --- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (4) | They may be offered to fulfill the Companys obligation under warrants or convertible bonds issued or guaranteed in accordance with the authorization of the Management Board under
Item 8 of the Annual Shareholder Meeting of May 25, 2007.
| | --- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (5) | They may be offered for purchase or transferred to third parties making substantial contributions to the realization of the Companys corporate goals in their capacity of strategic
partners of the Company or its affiliated subsidiary companies.
| | --- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



Authorizations may be utilized once or several times, individually or jointly. Shareholders subscription rights to such treasury shares shall be excluded to the extent to which these shares are used in accordance with the
authorizations described under 2, 3, 4 and 5 above.



To date, the
Management Board has not made use of this authorization to acquire our own shares. We do not currently hold any treasury shares.



For further details regarding these authorizations we refer you to the Companys articles of association.



Form, Certification and Transferability of the Shares



The form and contents of our share certificates, dividend and renewal coupons are
determined by our Management Board with the consent of our Supervisory Board. We may combine individual shares into share certificates that represent multiple shares (global shares, global certificates). Shareholders have no right to receive
individual share certificates and all shares are represented by one or more global bearer share certificate.



All of our outstanding shares are bearer shares. If a resolution regarding a capital increase does not specify whether such increase will be in bearer or registered
form, the new shares resulting from such capital increase will be bearer shares by default. Any resolution regarding a capital increase may determine the profit participation of the new shares resulting from such capital increase in deviation from
§ 60(2)(3) of the German Stock Corporation Act.



Our shares are
freely transferable, with the transfer of ownership governed by the rules of the relevant clearing system.



Changes in Our Share Capital During the Last Three Fiscal Years



Since January 1, 2005, our share capital has changed as follows (the dates listed refer to the dates of registration of the capital measure with the commercial register):



Fiscal Year 2005 (January 1 to December 31, 2005)



Increase out of authorized capital from 28,682,680 by 6,524 to 28,689,204,
registered on January 31, 2005;



Registration on February 10,
2005 of the increase out of conditional capital during 2004 from 28,689,204 by 58,514 to 28,747,718;



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Registration on March 9, 2005 of the increase out of conditional capital during 2004 from 28,747,718 by 16,836 to 28,764,554;



Increase out of authorized
capital from 28,764,554 by 1,311,098 to 30,075,652, registered on March 17, 2005;



Increase out of authorized capital from 30,075,652 by 5,285 to 30,080,937, registered on May 12, 2005;



Increase out of authorized capital from 30,080,937 by 5,312 to 30,086,249,
registered on December 13, 2005;



The capital increase out of
authorized capital in the amount of 1,311,098, registered on March 17, 2005, was subscribed by the shareholders of GPC Biotech Forschungsgesellschaft mbH. All
capital increases related to share issuances resulting from the exercise of stock options were covered by either authorized or conditional capital.



Fiscal Year 2006 (January 1 to December 31, 2006)



Registration on January 26, 2006 of the increase out of conditional capital during 2005 from 30,086,249 by 65,508 to 30,151,757;



Increase out of authorized capital from 30,151,757 by 2,860,000 to 33,011,757, registered on March 23, 2006;



Increase out of
authorized capital from 33,011,757 by 4,750 to 33,016,507, registered on May 2, 2006;



Increase out of authorized capital from 33,016,507 by 7,750 to 33,024,257, registered on July 25, 2006;



Increase out of authorized capital from 33,024,257 by 10,210 to 33,034,467,
registered on September 18, 2006;



Increase out of authorized
capital from 33,034,467 by 68,870 to 33,103,337, registered on December 12, 2006;



The capital increase out of authorized capital in the amount of 2,860,000,
registered on March 23, 2006, was subscribed by DH Capital GmbH & Co. KG and OH Beteiligungen GmbH & Co. KG. All capital increases related to share issuances resulting from the exercise of stock options were covered by either
authorized or conditional capital.



Fiscal Year 2007 (January 1 to
December 31, 2007)



Increase out of authorized capital from
33,103,337 by 1,564,587 to 34,667,924, registered on February 5, 2007;



Registration on April 19, 2007 of the increase out of conditional capital during 2006 from 34,667,924 by 1,129,066 to 35,796,990;



Increase out of authorized capital from 35,796,990 by 174,000 to 35,970,990, registered on July 30, 2007;



Registration on
September 27, 2007 of the increase out of conditional capital during 2007 from 35,970,990 by 297,633 to 36,268,623;



Increase out of authorized capital from 36,268,623 by 171,880 to 36,440,503, registered on October 29, 2007;



The shares resulting from the capital increase out of authorized capital in the amount
of 1,564,587, registered on February 5, 2007, was subscribed by Lehman Brothers International



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(Europe), London, UK, and subsequently placed with institutional investors. All capital increases related to share issuances resulting from the exercise of stock
options were covered by either authorized or conditional capital.



In
2007, another 396,350 conversion rights attached to convertible bonds and stock options covered by conditional capital have been exercised. Thus, our share capital currently amounts to 36,836,853. The exercise of these 396,350 conversion rights attached to convertible bonds and stock options rights has been registered with the commercial register on February 28, 2008.



Objects and Purposes



As described in Section 2 of our Articles of Association, our business purpose is the research, development, marketing,
production and distribution of pharmaceutical, diagnostic and biotechnological products, technologies and procedures and the provision of related services and granting of licenses, as well as the acquisition, sale, utilization and administration of
all kinds of intellectual property rights. We may perform actions and transactions which may serve our purpose directly or indirectly. We may also establish, take over, represent or acquire equity participations in other companies in Germany and
abroad and conclude business or cooperation agreements with other companies and may, fully or partially, pursue our purpose via subsidiaries, affiliates, offices and branches in Germany and abroad.



Governance



In accordance with the German Stock Corporation Act (Aktiengesetz), GPC Biotech has two separate boards of directors, the
so-called dual board system. These are the Vorstand, or Management Board, and the Aufsichtsrat, or Supervisory Board. The two boards are separate, and generally no individual may simultaneously be a member of both boards.



Management Board



The Management Board is responsible for the day-to-day management of the Companys
business in accordance with applicable law, the Articles of Association (Satzung) and the internal rules of procedure (Geschäftsordnung) adopted by the Supervisory Board.



According to our Articles of Association and the internal rules of procedure of the
Management Board, a quorum of the Management Board is present when all members were invited or requested to participate in a decision and three-quarters of its members participated. If not otherwise required by law, the Management Board makes
decisions by a simple majority of the votes cast. In case of deadlock, the resolution is not adopted.



The Management Board represents GPC Biotech in its dealings with third parties. The Management Board is required to ensure that adequate risk management and
internal monitoring systems exist within the Company to detect risks relating to business activities at the earliest stage possible.



The Management Board reports regularly to the Supervisory Board about the Companys operations and business strategies and prepares special reports upon
request. The Management Board and the Supervisory Board must cooperate closely for the benefit of the Company. Pursuant to our Articles of Incorporation, the Management Board can consist of only one (1) member members. However, currently, our
Management Board is composed of 2 members, Dr. Bernd Seizinger and Dr. Torsten Hombeck. The two members of the Management Board jointly or one member of the Management Board and the holder of a special power of attorney jointly may legally
represent the Company. Our CEO, Dr. Seizinger, is currently appointed for a term of five (5) years and our CFO, Dr. Hombeck, is currently appointed for a terms of two (2) years, in each case with the possibility of re-appointment
thereafter (See Item 6 Directors, Senior Management and EmployeesCompensation



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of Management Board and Supervisory Board MembersCompensation of Members of the Management Board for more details on the service contract of our Management
Board Members). A member of the Management Board may be removed by the Supervisory Board prior to the expiration of that members term only for cause (in accordance with the German Stock Corporation Act). A member of the Management Board may
not vote on matters relating to certain contractual agreements between such member and the Company, and may be liable to the Company if such member has a material interest in any contractual agreement between the Company and a third party which was
not disclosed to and approved by the Supervisory Board. Further, as the compensation of the Management Board members is set by the Supervisory Board, Management Board members are unable to vote on their own compensation.



Supervisory Board



The Supervisory Board has comprehensive monitoring functions. To ensure that these
functions are carried out properly, the Management Board must, among other requirements, regularly report to the Supervisory Board on current business operations and future business planning (including financial, investment and personnel planning).
The principal function of the Supervisory Board is to supervise and oversee the Management Board. It is also responsible for appointing and removing members of the Management Board and representing GPC Biotech in connection with transactions between
a member of the Management Board and the Company. The Supervisory Board may at any time request special reports regarding the affairs of GPC Biotech, the legal or business relations of GPC Biotech and its subsidiary or the affairs of its subsidiary
to the extent that the affairs of such subsidiary may have a significant impact on GPC Biotech.



The Supervisory Board is not permitted to make management decisions, but, in accordance with German law and in addition to its statutory responsibilities, the
Supervisory Board of GPC Biotech has determined that the following matters, among others, require its prior consent:



| |  | the conclusion, amendment and termination of license, know-how, patent and collaboration agreements above specified thresholds;
| | - | -------------------------------------------------------------------------------------------------------------------------------



| |  | the acquisition, sale and encumbrance of real estate property;
| | - | --------------------------------------------------------------



| |  | the commencement, acquisition, discontinuance or sale of businesses, business units or branch offices;
| | - | ------------------------------------------------------------------------------------------------------



| |  | the granting of guarantees, securities or other collateral (other than product warranties/guarantees) above a specified threshold;
| | - | ----------------------------------------------------------------------------------------------------------------------------------



| |  | fiscal and financial planning and budgeting;
| | - | --------------------------------------------



| |  | the granting or termination of profit participation rights;
| | - | -----------------------------------------------------------



| |  | the purchase or sale of equity interest.
| | - | ----------------------------------------



The Companys Supervisory Board currently consists of six (6) members (See Item 6 Directors, Senior Management and
EmployeesSupervisory Board). The Supervisory Board member are elected by the shareholders at the annual general shareholders meeting by three-quarters of the votes cast and may be removed only by the shareholders at a
shareholders meeting by three-quarters of the votes cast. The Supervisory Board elects a chairman and a deputy chairman among its members by a majority of vote of its members. Unless otherwise provided by law, the Supervisory Board acts
by simple majority. In the case of any deadlock the chairman has the deciding vote. The meeting agendas of the Supervisory Board are determined by the Chairman of the Supervisory Board. In advance of each meeting, the other members of the
Supervisory Board receive materials allowing them to prepare for the handling of the items on the agenda. The Supervisory Board holds meetings on a regular basis without the Management Board. The Supervisory Board also conducts an annual
self-evaluation of the effectiveness of its overall performance pursuant to the German Corporate Governance Codex.



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The members of the Supervisory Board are each elected for a fixed term of approximately 3 years. The terms
expires at the close of the Annual General Shareholders Meeting of third fiscal year following the year in which the Supervisory Board was elected unless the Annual General Shareholders Meeting specifies a shorter term of office when
electing individual members of the Supervisory Board. The compensation of the members of the Supervisory Board is determined by the Articles of Incorporation and is described in greater detail in Item 6 Directors, Senior Management and
EmployeesCompensation of Supervisory Board



Board Committees



To assist the Supervisory Board
in carrying out its duties, certain committees have been created in accordance with the Companys Articles of Association and the internal rules of procedure of the Supervisory Board. The Board Committees may, to the extent legally possible,
also be charged with decision-making powers. The Supervisory Board may, at its discretion, establish, permanently or temporarily, other committees and give them decision-making powers. Currently, the Supervisory Board has the committees described
below.



Audit Committee:    GPC Biotechs
Audit Committee is directly responsible for:



| |  | overseeing external accounting and risk management matters;
| | - | -----------------------------------------------------------



| |  | ensuring the independence of the external auditors;
| | - | ---------------------------------------------------



| |  | determining the scope of the external audit and engaging the external auditors as elected by the shareholders at Annual General Meetings;
| | - | -----------------------------------------------------------------------------------------------------------------------------------------



| |  | determining specific key aspects of the external audit and the compensation of the external auditors; and communicating with the external auditors on a regular basis.
| | - | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------



The current members of our Audit Committee are James
Frates (Chairman), Dr. Metin Colpan and Michael Lytton. The Supervisory Board has assured itself that the members of the Audit Committee have sufficient experience and ability in finance and matters of compliance to satisfy applicable legal and
listing requirements, including the requirements of Nasdaq and the U.S. Securities and Exchange Commission, and to enable them to adequately discharge their responsibilities. In addition, the Supervisory Board has determined that all current members
of the Audit Committee satisfy the independence requirements of NASDAQ Marketplace Rule 4350.



Compensation Committee:    The Compensation Committee reviews and approves the compensation policies and programs, including stock option programs and similar incentive-based compensation. It is
responsible for reviewing and approving the compensation paid to the members of the Management Board and oversees ongoing personnel matters of the members of the Management Board, including their membership on the boards of other companies. The
current members of the Compensation Committee are Dr. Jürgen Drews (Chairman), Michael Lytton and Peter Preuss.



Corporate Governance & Nominations Committee:    The Corporate Governance & Nominations Committee assists the
Supervisory Board in the identification and appointment of candidates for the Management Board and the Supervisory Board. In addition, this Committee monitors the Companys compliance with its Corporate Governance Principles and other
applicable rules, regulations and laws related to corporate governance. The current members of the Corporate Governance & Nominations Committee are Peter Preuss (Chairman), Donald Soltysiak, Dr. Metin Colpan and James Frates.



Notification and Disclosure Obligations



Our Articles of Association do not require our shareholders to advise us when their
holdings exceed specified thresholds. Under the German Securities Trading Act (Wertpapierhandelsgesetz),



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however, holders of the voting securities of an issuer whose home country is the Federal Republic of Germany and whose securities are admitted to trading on an
organized market are required to notify without undue delay and in writing the issuer in which they hold the securities and the German Federal Financial Supervisory Authority (Bundesanstalt für Finanzdienstleistungsaufsicht) of the level
of their holdings whenever such holdings reach, exceed or fall below certain thresholds. These thresholds are set at 3%, 5%, 10%, 15%, 20%, 25%, 30%, 50% and 75% of the issuers outstanding voting rights. In addition, anyone who holds, directly
or indirectly, financial instruments that result in an entitlement to acquire, on ones own initiative alone and under a legally binding agreement, shares in an issuer whose home country is the Federal Republic of Germany that carry voting
rights and have already been issued, must, without undue delay, notify this to us as the issuer and to the German Federal Financial Supervisory Authority if the thresholds mentioned above have been reached, exceeded or fallen below, with the
exception of the 3% threshold. We have to publish the notifications received without undue delay, but not later than three trading days following receipt of the notification. A domestic issuer shall also publish the total number of voting rights at
the end of each calendar month during which the number of voting rights has increased or decreased. The calculation of the percentage of voting rights shall be based on the latest publication of the total number of voting rights of the issuer. If a
shareholder fails to notify the issuer or the German Federal Financial Supervisory Authority as required, he or she cannot exercise any rights associated with the shares for as long as the default continues. Additionally, the German Takeover Act
(Wertpapiererwerbs- und Übernahmegesetz) requires the publication of the acquisition of control, which is defined as holding of at least 30% of the voting rights in a target company, within seven days.



German Foreign Exchange Controls



In accordance with UN and EU laws and regulations, Germany currently does not restrict capital movements between Germany and other
countries except for capital transactions with Iraq, Burma/Myanmar, Zimbabwe and institutions of the Taliban party in Afghanistan, Osama bin Laden and Al Qaida.



For statistical purposes, subject to certain exceptions, each corporation or person domiciled in Germany is required to report to the Deutsche Bundesbank each
payment received from or made to a corporation or person not domiciled in Germany in excess of 12,500 (or an equivalent amount in a foreign currency). Moreover,
all claims and liabilities of a corporation or person domiciled in Germany against or towards a corporation or person not domiciled in Germany in excess of 5 million (or an equivalent amount in a foreign currency), individually or in the aggregate, are required to be reported to the Deutsche Bundesbank.



General Meetings, Resolutions and Voting Rights



General meetings are held at our registered office or in a German city that is the seat of a stock exchange. In general, annual general meetings are convened by our
Management Board. The Supervisory Board is additionally required to convene a general meeting if this is in the best interest of GPC Biotech. Both our Management Board and our Supervisory Board may convene extraordinary general meetings. In
addition, shareholders who, individually or as a group, own at least five percent of our share capital may request our Management Board to convene a general meeting. If our Management Board does not convene a general meeting when so requested, the
shareholders may petition the competent German court to be authorized to convene a general meeting.



We must publish the invitation to a general meeting and the agenda thereof in the electronic version of the German Federal Gazette (elektronischer
Bundesanzeiger) at least one month before the last day on which shares may be deposited in order for shareholders to exercise their voting rights. Shareholders who, individually or as a group, own at least five percent or 500,000 of our share capital may require that modified or additional items be added to the agenda of the general meeting and that these items be published before the
general meeting takes place.



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Our annual general meeting must take place within the first eight months of each fiscal year. Among other things,
the annual general meeting is required to decide on the following issues:



| |  | appropriation and use of annual net income;
| | - | -------------------------------------------



| |  | discharge or ratification of the actions taken by the members of our Management Board and our Supervisory Board;
| | - | ----------------------------------------------------------------------------------------------------------------



| |  | the election of our statutory auditors;
| | - | ---------------------------------------



| |  | increases or decreases in our share capital;
| | - | --------------------------------------------



| |  | the election of Supervisory Board members; and
| | - | ----------------------------------------------



| |  | to the extent legally required, the approval of GPC Biotechs unconsolidated financial statements.
| | - | --------------------------------------------------------------------------------------------------



Unless otherwise prescribed by the German Stock Corporation Act, the resolutions of our general meeting are passed with a simple
majority of the votes cast. Where the German Stock Corporation Act requires a majority of the share capital present or represented at the meeting for adoption of a resolution, a simple majority of the share capital present or represented at the
meeting is sufficient. Neither the German Stock Corporation Act nor our Articles of Association provide for a minimum participation for a quorum for general meetings. Under the German Stock Corporation Act, resolutions of fundamental importance
require a simple majority of the votes cast and a majority of at least three quarters of the share capital present or represented at the meeting at the time of adoption of the resolution. Resolutions of fundamental importance include, in particular,
capital increases with exclusion of preemptive rights, capital decreases, the creation of authorized or conditional share capital, the dissolution of GPC Biotech, a merger into or with another company, split-offs and split-ups, the transfer of all
or substantially all of our assets, the conclusion of inter-company agreements (Unternehmensverträge) in particular control agreements (Beherrschungsverträge) and profit and loss transfer agreements
(Ergebnisabführungsverträge), and a change of the legal form of GPC Biotech.



Our Articles of Association provide that, to the extent permitted by applicable law, our general meetings may be transmitted audio-visually via electronic media by a method and in a scope determined by our Management Board,
with the consent of the Supervisory Board, provided that this possibility was announced in the invitation to the general meeting.



Each share entitles its holder to one vote. Shareholders are entitled to attend general meetings and to exercise their voting rights if, by the seventh day before
the day of the general meeting, they deposit their shares with a depositary designated in the invitation, a German notary or at a central depositary for securities until the end of the general meeting (the deposit deadline). The deposit
deadline for attending general meetings is published concurrently with the notice convening the general meeting in the electronic version of the German Federal Gazette. The depositing with a depositary shall also be in proper form if shares are kept
in a blocked securities account with a credit institution with the depositarys consent until the end of the general meeting. If the shares are deposited with a German notary, a central depositary for securities or with any depositary
designated in the invitation, the certificate to be issued by the notary, a central depositary for securities or the designated depositary must be submitted to us no later than the business day (other than a Saturday) following the deposit deadline.
Proxies require written authorization, which may be given electronically, as per further instructions determined by our Management Board. These instructions will be published concurrently with the notice convening the general meeting in the
electronic version of the German Federal Gazette. The Chairman of our Supervisory Board, or, in his absence, another member of our Supervisory Board appointed by the Chairman, will chair general meetings.



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No Limitation on the Right to Own Securities, including on Foreign Ownership.



With the exception of buying back treasury stock by a stock corporation, which is
limited to 10% of the share capital, there are no limitations under German law or in our Articles of Incorporation on the right to own securities, including on the right of persons who are not citizens or residents of Germany to hold or vote
ordinary shares.



Liquidation.



If GPC Biotech AG were to be liquidated, any liquidation proceeds remaining after all
of our liabilities were paid would be distributed to our shareholders in proportion to their shareholdings.



Change in Control.



There are no provisions in the Articles of Incorporation of GPC Biotech AG that would have an effect of delaying, deferring or preventing a change in control of GPC
Biotech AG and that would only operate with respect to a merger, acquisition or corporate restructuring involving it or any of its subsidiaries.



Material Contracts



Spectrum Pharmaceuticals



In September 2002, we entered into a Co-Development and License Agreement with Spectrum Pharmaceuticals, Inc. (formerly known as Neotherapeutics, Inc.), under which
we received an exclusive license, with the right to grant sublicenses, for the commercialization of satraplatin in the field of treating cancer in humans. This license includes a sublicense of all patent rights and other rights previously licensed
to Spectrum Pharmaceuticals by Johnson Matthey plc, the company that invented satraplatin. In the event that the license agreement between Spectrum Pharmaceuticals and Johnson Matthey is terminated, Johnson Matthey has agreed with Spectrum
Pharmaceuticals that our sublicense will be automatically assigned to Johnson Matthey, which will receive all rights and have all obligations currently held by Spectrum Pharmaceuticals. However, we have limited ability to enforce directly any
Spectrum Pharmaceuticals rights or Johnson Mattheys obligations in their agreement.



Under the agreement with Spectrum Pharmaceuticals, in addition to various smaller payments, we made an upfront payment to Spectrum Pharmaceuticals of $ 2.0 million in 2002, a further milestone payment of $ 2.0 million
in September 2003 upon the first dosing of the first patient in the first registrational clinical trial of satraplatin, a further milestone payment of $ 4.0 million in May 2007 after the FDA accepted our NDA filing for satraplatin and a further
milestone payment of $ 2.0 million after the EMEA accepted the satraplatin MAA. Of the 2003 payment, $ 1.0 million was made in the form of an equity investment by us in Spectrum Pharmaceuticals common stock. In addition, we are obligated
to make milestone payments to Spectrum Pharmaceuticals upon the occurrence of specific events in the development of satraplatin beginning with the acceptance by the FDA of an NDA for satraplatin. These milestone payments would total up to $18
million (including milestone payments already made) if all milestones were to be achieved. We also have established a joint development committee, comprised of three representatives from each company, responsible for the planning and oversight of
the development of satraplatin. The chairperson of the committee, a representative of GPC Biotech, has a tie-breaking vote in the event the committee cannot reach a unanimous decision.



If we market and sell satraplatin ourselves, Spectrum Pharmaceuticals will receive royalties on our net sales of products, commencing
on the date of first commercial sale and running until the expiration of the last-to-expire valid claim of a licensed patent or patent application. In the event we decide to market satraplatin without a partner in the United States, Spectrum
Pharmaceuticals will also



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have the right to elect to co-promote the product with us on terms to be negotiated. Spectrum Pharmaceuticals is also entitled to receive a share of sublicense fees
and royalties received by us from our co-development and license agreement with Pharmion and if we enter into a marketing arrangement with another company outside of the Pharmion territories. The term of the agreement ends with the expiration of our
obligation to pay Spectrum Pharmaceuticals royalties on sales of products although some obligations, such as provisions relating to confidentiality and indemnification, survive termination. In addition, the agreement may be terminated earlier by
either party, based upon material breach or the commencement of bankruptcy or insolvency proceedings involving the other, or by us upon six months notice to Spectrum Pharmaceuticals.



Celgene Corporation



On December 19, 2005, we entered into a Co-Development and License Agreement with
Pharmion GmbH, a wholly-owned indirect subsidiary of Pharmion Corporation, related to satraplatin. Pharmion Corporation has since merged with Celgene Corp., who became a successor to all of our agreements with Pharmion. Under the terms of the
agreement, Celgene gained exclusive commercialization rights for satraplatin for Europe, the Middle East, including Turkey, Australia and New Zealand, while we retained our current rights to the North American market and all other territories.
Celgene made an upfront payment of $37.1 million, including an $18 million reimbursement for satraplatin clinical development costs incurred prior to October 1, 2005 and $19.1 million for funding of clinical development costs incurred after
October 1, 2005 but prior to the effective date of the agreement and certain future clinical development to be conducted jointly. We also agreed to pursue a joint development plan to evaluate development activities for satraplatin in a variety
of tumor types and will share global development costs, for which Celgene has made an additional commitment of $22.2 million, in addition to the $37.1 million in initial payments. Celgene is also obligated to pay us an additional $30.5 million
based on the achievement of certain regulatory filing and approval milestones, and $15 million for each subsequent EMEA approval for certain additional indications up to a maximum of $75 million for such approvals. We also have the right to receive
royalties on net sales of satraplatin in Celgenes territories at rates of 26% to 30% on annual net sales up to $500 million, and 34% on annual net sales over $500 million. Finally, Celgene is obligated to pay sales milestones totaling up to
$105 million, based on the achievement of significant annual sales levels in the Celgene territories. The Agreement also provides for a joint executive committee to oversee and coordinate the parties activities, as well as a joint development
committee and a joint commercialization committee. We will each lead regulatory and commercial activities in our respective territories. The Co-Development and License Agreement terminates on a country by country basis with the expiration of
Celgenes obligation to pay us royalties on sales of satraplatin. Upon termination, Celgene will retain a non-exclusive, fully-paid, royalty-free license to continue the commercialization of satraplatin in the Celgene territories.



Contemporaneously with the Co-Development and License Agreement, we also entered
into a Supply Agreement. Pursuant to the terms of the Supply Agreement, Celgene has agreed to purchase 100% of its requirements for satraplatin from us, and we have agreed to manufacture and supply the requirements of Celgene for satraplatin.
Pricing is based upon 110% of the fully allocated costs of manufacture, subject to annual adjustment. The parties will form a joint manufacturing committee to, among other things, oversee activities with respect to the manufacture of satraplatin, to
coordinate regulatory activities relating to its manufacture and to establish work plans for analytical methods transfer.



Yakult



On June 25, 2007, the Company entered into a license agreement with Yakult Honsha Co. Ltd for satraplatin in Japan. Under the terms of the agreement, Yakult
gains exclusive commercialization rights to satraplatin for Japan and will take the lead in developing the drug in Japan. Yakult made an upfront payment of ¥1.2 billion (approximately 7.4 million) to the Company as reimbursement for past



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satraplatin clinical development expenses. Under the agreement, Yakult is also obligated to make additional payments to the Company, based on the achievement of
certain regulatory filing and approval milestones. In addition, the Company will receive a minimum of 21% royalties on net sales of satraplatin in Japan.



Under the license agreement, Yakult is obligated to use commercially reasonable efforts to develop and obtain regulatory approval for satraplatin in Japan, which
includes certain minimum financial commitments towards the development and commercialization of the product, as well as responsibility for the conduct of clinical trails in Japan and the filing of a drug approval application. The license agreement
also provides for a joint steering committee to monitor the development and commercialization of satraplatin in Japan.



The license agreement stays in effect until terminated by either or both parties. Upon termination, all licenses and sublicenses granted to Yakult under the license
agreement will terminate and the Company will receive, inter alia, a perpetual, irrevocable, exclusive, royalty-bearing license for Japan to the relevant Yakult intellectual property on terms and conditions to be negotiated between the
parties.



Bristol-Myers Squibb



Through our acquisition of Mitotix, Inc. in March 2000, we are party to a research,
development and marketing agreement with Bristol-Myers Squibb, as successor to DuPont Pharmaceuticals, in the field of cyclin-dependent kinase inhibitors. Pursuant to an amendment to the agreement in April 2000, the research collaboration was
terminated, although various provisions of the agreement including some sublicenses and milestone and royalty obligations remained in effect. We are entitled to milestone payments, totaling $16 million for the first product and totaling $8 million
for any subsequent product if all milestones are achieved, and royalties on net sales for any products developed and commercialized by Bristol-Myers Squibb based upon lead compounds identified during the collaboration. Both we and Bristol-Myers
Squibb also retain exclusive rights to develop and commercialize certain other selected compounds tested during the collaboration. Each party is obligated to make milestone and royalty payments to the other for any product incorporating any of these
selected compounds. Aggregate milestones payable by Bristol-Myers Squibb for any product that incorporates one of these selected compounds are the same as discussed above. For the first product developed and commercialized by us that incorporates
one of these selected compounds we would owe Bristol-Myers Squibb milestone payments totaling $19.5 million and totaling approximately $5 million for any subsequent product, in both cases if all milestones are achieved.



In addition, both we and Bristol-Myers Squibb have co-exclusive rights to utilize the
intellectual property resulting from the collaboration for the identification, research, development and commercialization of new cyclin-dependent kinase inhibitors. We are each obligated to make royalty payments to the other for any product
incorporating a compound independently identified during a specified time period through the use of this co-exclusive intellectual property. In addition, Bristol-Myers Squibb would owe us milestone payments as described above for any product
incorporating a compound identified through the use of this intellectual property during the same specified time period. The royalty term expires on a country-by-country basis on the later of the date of expiration of the last- to-expire licensed
patent having a valid claim covering a given product and the date that is ten years from the date of the first commercial sale. Either party may terminate the agreement based on material breach or the commencement of bankruptcy or insolvency
proceedings involving the other, and we may also terminate the license to Bristol-Myers Squibb upon six months notice for failure to diligently pursue the discovery and development of products. The obligations under certain provisions of the
agreement, including provisions relating to confidentiality and non-solicitation of employees, survive termination.



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Axxima Pharmaceuticals



On March 2, 2005, we entered into an Asset Purchase Agreement for the acquisition of substantially all of the assets of Axxima Pharmaceuticals
AG. Axxima, a kinase drug discovery firm based in Munich, Germany which filed for insolvency in December 2004. Axximas assets were transferred to a newly formed holding company. We purchased the holding company, which, in addition to
substantially all of the assets of Axxima, held a net 8.7 million cash infusion from investors and substantially all of Axximas patents, patent
applications and know-how as well as several early-stage drug discovery programs in the areas of cancer. In addition to the initial purchase price of 2 million, the Asset Purchase Agreement obligates us and any exclusive licensee or purchaser of relevant Axxima patents, to make milestone payments to the insolvency receiver of Axxima for the entry of three compounds protected
by Axximas patent estate at the time of entry, into Phase 1, 2 and 3 clinical trials, up to a maximum total amount of 9 million.



Taxation



German Taxation



Prospective purchasers of shares or ADSs are urged to consult their tax advisers about the tax consequences of the acquiring, holding, disposal, or other
transfer of shares or ADSs and the procedures for obtaining a possible refund of German withholding tax paid.



The following discussion gives a brief overview as regards the taxation of corporations in Germany and is a summary of certain material German tax consequences for
beneficial owners of GPC Biotechs ordinary shares or ADSs:



| | (i) | who are not a resident of Germany for German tax purposes; and
| | --- | --------------------------------------------------------------



| | (ii) | whose shares or ADSs do not form part of the business property of a permanent establishment or fixed base in Germany
| | ---- | --------------------------------------------------------------------------------------------------------------------



| | (such | owner is referred to as Non-German Holder in this section).
| | ----- | -------------------------------------------------------------



The discussion is based on tax laws of Germany as in effect on the date of this annual report, including the Convention between the United States of America and the
Federal Republic of Germany for the Avoidance if Double Taxation and the Prevention of Fiscal Evasion with Respect to Taxes on Income and Capital and to Certain Other Taxes (the Treaty). Such tax laws and the Treaty are subject to
change, possibly with retroactive effect.



The following overview does
not purport to be a comprehensive discussion of all German tax consequences relevant for an investment in GPC Biotechs ordinary shares or ADSs. Therefore, you should consult your tax advisor regarding the German tax consequences of the
purchase, ownership, disposition or transfer of GPC Biotechs shares or ADSs and the procedure to follow to obtain a refund of German taxes withheld from dividends. Only these advisors are in position to duly consider your specific tax
situation.



Taxation of Corporations in Germany



Corporations being resident in Germany for tax purposes (German resident
corporation) are generally subject to corporate income tax for the fiscal year 2007 at a rate of 25% plus 5.5% solidarity surcharge thereon, amounting to a total of 26.375%. This tax rate applies irrespectively of whether profits are
distributed or retained. Pursuant to the German Business Tax Reform Act 2008, from fiscal year 2008 onwards, the combined tax rate for corporate income tax and solidarity surcharge will be reduced to 15.825%.



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German resident corporations are also subject to profit-related trade tax (Gewerbesteuer), the exact amount
of which depends on the municipality in which the corporation maintains its business establishment(s). The trade tax rates range between 15% and 20% (between 7% and 17% from fiscal year 2008 onwards). Trade tax isfor the last time in the
fiscal year 2007a deductible item in computing the corporations tax base for corporate income and trade tax purposes. From fiscal year 2008 onwards, trade tax is no longer deductible as business expenses for corporate income and trade
tax purposes.



Dividend distributions received by German resident
corporations are generally 95% exempt from corporate income tax. Dividend distributions received by a German resident corporation are generally 95% exempt from trade income tax, if the corporation holds, as of the beginning of the relevant
assessment period, at least 10% (from calendar year 2008 onwards: 15%) of the share capital of the distributing corporation. There are further requirements for dividend distributions received from entities not resident in Germany for this trade tax
exemption.



The use of loss carry-forwards (i.e. the setting-off against
profits) is limited under German tax law. According to so-called minimum taxation, only 60% of the annual profits exceeding EURO 1 million can be set-off against existing loss carry forwards. This applies to corporate income tax as
to trade tax.



German Business Tax Reform Act 2008 (Unternehmensteuerreform
2008)



Inter alia the following important changes
have been introduced by the German Business Tax Reform Act 2008:



Germany introduced the so-called Interest Ceiling Rules (Zinsschranke), which disallowwith narrow exemptionsan immediate deduction of net interest expenses (i.e. the surplus of interest paid minus interest received)
exceeding 30% of the corporations taxable earnings before interest and ordinary depreciation/amortization (EBITDA). The interest expenses which cannot be deducted due to the aforementioned limitation by the Interest Ceiling Rules
can be carried forward.



The use of loss carry forwards and annual losses
will inter alia be limited if more than 25% of the shares or voting rights (Stimmrechte) of the company are transferred to one purchaser or related parties or to a group of purchasers with similar interests (gleichgerichteten
Interessen) within a period of five years. Detrimental transfers exceeding 25% (but not 50%) of the shares or voting rights result in a pro-rata diminution of the existing loss carry forwards (including, but not limited to interest carry
forwards under the Interest Ceiling Rules) and of annual losses suffered prior to the detrimental transfer of shares or voting rights. The use of such loss carry-forwards and annual losses suffered prior to the harmful transfer is denied entirely in
the event that inter alia more than 50% of the shares or voting rights are transferred within five years. This applies to corporate income tax as trade tax.



Taxation of Shareholders



Withholding Tax



Dividends paid by a German resident corporation are subject to withholding tax at a tax rate of 20% of the gross amount of the dividend. In addition, the solidarity
surcharge of 5.5% on the withholding tax will be retained, resulting in a total withholding tax rate of 21.1%. According to the German Business Tax Reform Act 2008 the withholding tax on dividends will increase to 25% for dividends paid after
31 December 2008 with the result of a total withholding tax rate of 26,375% of the gross amount of the dividends. However, in case that the Non-German Holder is a corporation being limited liable to tax in Germany two-fifth of the retained
withholding tax will, in principle, be reimbursed if the dividends are paid after 31 December 2008; this finally results in a withholding tax of 15% (plus a solidarity surcharge).



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The withholding tax rate may be reduced for Non-German Holders by an applicable double tax treaty. Under most
double tax treaties the withholding tax rate is reduced to 15%. The reduction is granted by way of a refund of the excess of the amount of tax withheld (including the solidarity surcharge) over the applicable treaty rate. The application for refund
must be filed with the German Federal Office for Taxes (Bundeszentralamt für Steuern), An der Küppe 1, D-53225 Bonn, Germany). The relevant forms can be obtained from the German Federal Office for Taxes or from German embassies and
consulates.



Special Tax Rules for U.S. Holders



Under the Treaty, the withholding tax rate is reduced to 15% of the gross amount of the
dividends for U.S. holders (as defined below in United States Federal Income Taxation) that are eligible for the benefits of the Treaty and that hold less than 10% of the voting shares in GPC Biotech. For eligible U.S. holders that hold
10% of the voting shares or more the withholding tax rate is reduced to 5%. Under further requirements the withholding tax may be reduced to zero. The reduction of withholding tax is granted by way of refund as discussed in the preceding paragraph.



Withholding Tax Refund Procedure for U.S. Holders



For shares and ADSs kept in custody with The Depositary Trust Company (DTC)
in New York or one of its participating banks, the German tax authorities have introduced a collective procedure for the refund of German withholding tax and the solidarity surcharge thereon. Under this procedure, DTC may submit claims for refunds
payable to eligible U.S. holders under the Treaty collectively to the German tax authorities on behalf of the holders. The German Federal Tax Office will pay the refund amounts on a preliminary basis to DTC, which will pay these amounts to the
eligible U.S. holders. The Federal Tax Office may review whether the refund was made in accordance with the law within four years after making the payment to DTC. Details of this collective procedure are available from DTC.



Alternatively, a newly introduced simplified collective refund procedure based on
electronic data exchange (Datenträgerverfahren) may be available. Financial institutions that deal with dividend distributions of GPC Biotech (for example, custodian banks or clearing offices) or GPC Biotech itself may, subject to
certain conditions, apply to participate in this procedure at the German Federal Tax Office. Upon acceptance, the participant may electronically file collective refund claims with the German Federal Tax Office.



Individual claims for refund may be made on a special German form, which must be filed
with the German Federal Office for Taxes (Bundeszentralamt für Steuern) An der Küppe 1, D-53225 Bonn, Germany. Copies of the required form may be obtained from the German Federal Tax Office at the same address or from the Embassy of
the Federal Republic of Germany, 4645 Reservoir Road, N.W., Washington, D.C. 20007-1998. The form can also be downloaded from the following website: www.bzst.bund.de. Claims must be filed within a four-year period from the end of the calendar year
in which the dividend was received.



As part of the individual refund
claim, an eligible U.S. holder must submit to the German tax authorities the original bank voucher (or certified copy thereof) issued by the paying entity documenting the tax withheld, and an official certification on IRS Form 6166 of its last
United States federal income tax return. IRS Form 6166 may be obtained by filing a request for certification (generally on an IRS Form 8802, together with a $35 user fee) with the Internal Revenue Service. (Additional information, including IRS Form
8802 and the instructions to that respective form, can be obtained from the International Revenue Service http//www.irs.gov). Requests for certifications must include the eligible U.S. holders name, Social Security Number or Employer
Identification Number, tax return form number, and tax period for which the certification is requested. Requests for certification can include a



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request to the Internal Revenue Service to send the certification directly to the German tax authorities. If no such request is made, the Internal Revenue Service will
send a certification on IRS Form 6166 to the eligible U.S. holder, who then must submit this document with its claim for refund.



Capital Gains



Under German tax law as currently applicable, half of the capital gains from a disposal of shares or ADSs held by an individual Non-German Holder may be subject to
German income tax, if (i) the individual Non-German Holder or, in case of (a) gratuitous transfer(s), a legal predecessor has held, directly or indirectly, at any time during the five years preceding the disposal at least 1% of the share
capital of GPC Biotech or (ii) the Non-German Holder has acquired the shares or ADSs no earlier than 12 months before the disposition.



Gains from the disposal of shares or ADSs held by a corporate Non-German Holder are generally exempt from trade income tax and corporate income tax. If the
shareholder or, in case of (a) gratuitous transfer(s), a legal predecessor has held, directly or indirectly, at any time during the five years preceding the disposal, at least 1% of the share capital of the corporation, only 95% of the gain
from the disposal of the shares or ADSs may be exempt from corporate income tax and the solidarity surcharge. Losses deriving from the disposal of shares or ADSs are not tax-deductible.



Many double tax treaties, including the Treaty, however, provide complete exemption from German taxation of capital gains derived from
the disposal of shares or ADSs if and to the extent the shares or ADSs are not held as assets attributable to (i) a permanent establishment or (ii) a fixed base in Germany.



After 31 December 2008, capital gains derived by a disposal of shares or ADS are also subject to tax in Germany for a Non-German
Holder if amongst other requirements the capital gains are paid or credited by the debtor or by a domestic (i.e. German) financial institution (Kreditinstitut) or by a domestic finance service institution
(Finanzdienstleistungsunternehmen). The respective capital gains may be subject to withholding tax if the investment income is disbursed by a German financial institution or by a German finance institution within the meaning of the German
Banking Act or a German security trading company (Wertpapierhandelsunternehmen) or German security trading bank (Wertpapierhandelsbank). By way of exemption withholding tax may not be retained if the obligor of the capital gains is a
Non-German corporation.



However, for U.S. holders that qualify for
benefits under the Treaty the capital gains derived from a disposal of shares or ADSs are, in principle, exempted from tax in Germany.



Inheritance and Gift Tax



The transfer of shares or ADSs to other persons by way of gift or inheritance is only subject to German inheritance and gift tax, if:



| | (1) | the testator, donor, heir, donee or any other beneficiary had his domicile, residence or habitual abode in Germany or has not been living abroad as a German citizen for more than five years
without having a domicile in Germany; or
| | --- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (2) | the shares or ADSs belonged to assets attributable to a permanent establishment or a permanent representative of the testator or of the donor in Germany; or
| | --- | ------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (3) | the testator or donor, either alone or with other closely related persons, held at the time of the inheritance or donation, directly or indirectly at least 10% of the share capital of GPC
Biotech.
| | --- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



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The few presently applicable inheritance and gift taxation treaties (e.g. Estate, Inheritance and Gift Tax Treaty
between U.S. and Germany) Germany is a party to generally provide that German inheritance or gift tax is levied in case (1) and, with certain restrictions, in case (2) above.



Other German Taxes



Upon the acquisition, sale or other disposal of shares or ADSs, no German stock exchange transfer tax, value added tax, stamp duty or other tax is levied. Under
special circumstances it is possible that entrepreneurs elect for a value added tax duty of otherwise value added tax exempt turnovers. Net wealth tax is, at present, not levied in Germany.



United States Federal Income Taxation



The following discussion is a summary of material U.S. federal income tax
considerations applicable to the ownership and disposition of shares or ADSs by you, if you are a U.S. holder. In general, you will be a U.S. holder if:



| |  | you are the beneficial owner of shares or ADSs;
| | - | -----------------------------------------------



| |  | you are either (i) an individual resident or citizen of the United States, (ii) a corporation or any other entity treated as a corporation for U.S. federal income tax purposes
created in or organized under the laws of the United States or any state thereof, (iii) an estate whose income is subject to U.S. federal income taxation regardless of its source, or (iv) a trust if a U.S. court can exercise primary
supervision over the administration of the trust and one or more U.S. persons are authorized to control all substantial decisions of the trust;
| | - | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  | you own our shares or ADSs as capital assets;
| | - | ---------------------------------------------



| |  | you own directly or indirectly less than 10% of our outstanding voting stock;
| | - | -----------------------------------------------------------------------------



| |  | you are fully eligible for benefits under the Limitations on Benefits article of the Income Tax Treaty between the United States of America and Germany, signed August 29, 1989 (the
Treaty); and
| | - | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  | you are not also a resident of Germany for German tax purposes.
| | - | ---------------------------------------------------------------



The Treaty benefits discussed below generally are not available to holders who hold shares or ADSs in connection with the conduct of business through a permanent
establishment, or the performance of personal services through a fixed base, in Germany.



If a partnership holds shares or ADSs, the tax treatment of a partner generally will depend upon the status of the partner and the activities of the partnership. If you are a partner in a partnership that holds shares or ADSs,
you are urged to consult your own tax advisor regarding the specific tax consequences of owning and disposing of your shares or ADSs.



The summary does not purport to be a comprehensive description of all of the tax considerations that may be relevant to any particular holder, including tax
considerations that arise from rules of general application or that are generally assumed to be known by U.S. holders. This summary is based on provisions of the Internal Revenue Code of 1986, as amended (the Code), existing and proposed
U.S. Treasury Regulations, rulings, administrative pronouncements and judicial decisions in effect as of the date of this annual report. All of the authorities are subject to change, possibly with retroactive effect, and to differing
interpretations. In addition, this summary does not discuss all aspects of U.S. federal income taxation that may be applicable to investors in light of their particular circumstances or to U.S. holders who are subject to special treatment under U.S.
federal income tax law, including insurance companies, dealers in stocks or securities, financial institutions, tax-exempt organizations, persons subject to the alternative minimum tax, and persons having a functional currency other than the U.S.
dollar.



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U.S. holders are urged to consult with their own tax advisors regarding the tax consequences of the ownership and
disposition of shares or ADSs, including the effects of federal, state, local, foreign and other tax laws with respect to their particular circumstances.



For U.S. federal income tax purposes, if you own ADSs represented by ADRs, you generally will be treated as the owner of the shares represented by such ADRs.



Dividends



Subject to the passive foreign investment company rules discussed below, if we make any
distributions of cash or other property to you, you generally will be required to include in gross income the amount of any distributions (including the amount of any German taxes withheld in respect of such distribution as described above in the
German Taxation section), to the extent that such distributions are paid out of our current or accumulated earnings and profits as determined for U.S. federal income tax purposes. Distributions in excess of our earnings and profits will be applied
against and will reduce your tax basis in your shares or ADSs and, to the extent in excess of such tax basis, will be treated as gain from a sale or exchange of such shares or ADSs. Dividends paid by us will not be eligible for the dividends
received deduction applicable in some cases to U.S. corporations.



Any
dividend paid in euro, including the amount of any German taxes withheld therefrom, is includible in your gross income in effect on the date the dividend is received by you, in the case of shares, or by the Depositary, in the case of ADSs, in an
amount equal to the U.S. dollar value of the euro calculated by reference to the spot rate of exchange on such date, regardless of whether the euro are converted into U.S. dollars. Any gain or loss resulting from currency exchange fluctuations
during the period from the date the dividend is includible in your gross income to the date such payment is converted into U.S. dollars will be treated as U.S. source ordinary income or loss.



Any dividends paid by us to you with respect to shares or ADSs will be treated as
foreign source income and will be characterized generally as passive category income or, in the case of some U.S. Holders, general category income for U.S. foreign tax credit purposes. Subject to limitations, you may elect to
claim a foreign tax credit against your U.S. federal income tax liability for German income tax withheld from dividends received in respect of shares or ADSs. The rules relating to the determination of the foreign tax credit are complex.
Accordingly, you should consult your own tax advisor to determine whether and to what extent you would be entitled to the credit. The United States Treasury has expressed concerns that parties to whom ADSs are pre-released may be taking actions that
are inconsistent with the claiming of foreign tax credits by U.S. holders of ADSs. Accordingly, the discussion above regarding the creditability of German withholding tax on dividends could be affected by future actions that may be taken by the
United States Treasury. If you do not elect to claim a foreign tax credit, you may instead claim a deduction for German income tax withheld, but only for a year in which you elect to do so with respect to all foreign income taxes.



Qualified dividend income received by non-corporate U.S. holders in taxable
years beginning before January 1, 2011 generally will be taxed at a maximum rate of 15% rather than at rates applicable to other items of ordinary income. For this purpose, qualified dividend income generally includes dividends paid
on shares of U.S. corporations as well as dividends paid on shares of certain non-U.S. corporations if, among other things, (i) the shares of the non-U.S. corporation (including ADSs backed by such shares) are readily tradable on an established
securities market in the United States, or (ii) the non-U.S. corporation is eligible with respect to substantially all of its income for the benefits of a comprehensive income tax treaty with the United States which contains an exchange of
information program (the Treaty has been identified by the U.S. Treasury Department as a qualifying treaty). Dividends paid by us with respect to the shares or ADSs should constitute qualified dividend income for U.S. federal income tax
purposes unless we qualify as a PFIC (as discussed below) in which case they would be taxed at the higher rates applicable to other items of ordinary income.



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Sale or Exchange of Shares or ADSs



Subject to the passive foreign investment company rules discussed below, upon the sale or other disposition of shares or ADSs, you
generally will recognize capital gain or loss equal to the difference between the amount realized on the disposition and your adjusted tax basis in your shares or ADSs. Gain or loss upon the disposition of shares or ADSs generally will be U.S.
source gain or loss, and will be treated as long-term capital gain or loss if, at the time of the disposition, your holding period for the shares or ADSs exceeds one year. If you are a non-corporate U.S. holder, any capital gains recognized before
January 1, 2011 generally will be subject to U.S. federal income tax at a maximum rate of 15% if you have a holding period greater than one year. The deductibility of capital losses is subject to significant limitations.



The surrender of ADSs in exchange for shares pursuant to the Deposit Agreement
governing the ADSs will not be a taxable event for U.S. federal income tax purposes. Accordingly, you will not recognize any gain or loss upon such surrender.



Passive Foreign Investment Company Status



We currently believe that we will not be treated as a passive foreign investment company, or PFIC, for the taxable year ended December 31, 2007. We note,
however, that the decline in the trading prices of our shares in the last year, to the extent suggestive of a lower fair market value for our assets, may increase the likelihood that we will be treated as a PFIC for the taxable year ending
December 31, 2008, or for subsequent years. The determination of whether we are a PFIC is made on an annual basis and will depend on factors such as the composition of our income and assets from time to time as well as our share price, and
there are uncertainties in the application of the relevant rules. In addition, the U.S. Internal Revenue Service, or IRS, is not bound by our determinations regarding PFIC status, which are based on various assumptions and factual determinations,
and may successfully assert that we are or have been a PFIC for any particular year. Therefore, it is possible that we could be classified as a PFIC for any particular year.



A non-U.S. corporation will be classified as a PFIC in any taxable year in which, after taking into account the income and assets of
certain subsidiaries, either (i) at least 75% of its gross income is passive income or (ii) at least 50% of the average value of its assets is attributable to assets that produce or are held to produce passive income.



If we are classified as a PFIC for any taxable year, the so-called interest
charge regime of Code section 1291 will apply to any U.S. holder of shares or ADSs that does not make a mark-to-market election (as described below). Under the interest charge regime, (i) any gain you realize on the sale or
other disposition of the shares or ADSs (possibly including a gift, exchange in a corporate reorganization, or grant as security for a loan) and any excess distribution that we make to you (generally, any distributions to you in respect
of the shares or ADSs during a single taxable year that are greater than 125% of the average annual distributions received by you in the three preceding years, or if shorter, your holding period for the shares or ADSs), will be treated as ordinary
income that was earned ratably over each day in your holding period for the shares or ADSs, (ii) the portion of such gain or distribution that is allocable to prior taxable years will, with certain exceptions, be subject to tax at the highest
rate applicable to ordinary income for the relevant taxable years, regardless of the tax rate otherwise applicable to you, and (iii) the interest charge generally applicable to underpayments of tax will be imposed in respect of the tax
attributable to each such year.



In addition, under the interest charge
regime, special rules apply with respect to the calculation of the amount of the foreign tax credit with respect to excess distributions by a PFIC. In general, these rules allocate creditable foreign taxes over the U.S. holders holding period
for shares or ADSs and otherwise coordinate the foreign tax credit limitation rules with the PFIC rules.



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The interest charge regime would not apply to you if you were eligible for and timely made a valid qualifying
electing fund election, in which case you would be required to include in income on a current basis your pro rata share of our ordinary income and net capital gains. We do not currently intend to complete the actions necessary for U.S. holders
to make a qualifying electing fund election in the event that we are considered a PFIC for any taxable year.



If we are a PFIC and our shares or ADSs are treated as marketable securities under applicable Treasury regulations, you may avoid the interest charge
regime by making a valid mark-to-market election with respect to the shares or ADSs. If a mark-to-market election is made, the electing U.S. holder generally (i) will be required to recognize as ordinary income an amount
equal to the difference, if any, between the fair market value of the shares or ADSs and the holders adjusted tax basis in such shares or ADSs at the close of each taxable year, and (ii) if the U.S. holders adjusted tax basis in the
shares or ADSs exceeds their fair market value, will be allowed to deduct the excess as an ordinary loss, but only to the extent of the net amount of income previously included as a result of the mark-to-market election. A U.S. holders
adjusted basis in the shares or ADSs will be adjusted to reflect the amounts included or deducted with respect to the mark-to-market election, and any gain or loss on the disposition of shares or ADSs will generally be ordinary income, or, to the
extent of previously included mark-to-market inclusions, ordinary loss. The mark-to-market election is made on a shareholder-by-shareholder basis and, once made, cannot be revoked without the consent of the United States Internal Revenue Service
unless the shares or ADSs cease to be marketable. Under applicable Treasury regulations, marketable stock includes stock of a PFIC that is regularly traded on a qualified exchange or other market. Because our shares are traded on the
Frankfurt Stock Exchange and our ADSs are on Nasdaq, we expect the shares and ADSs to be treated as regularly traded, and a U.S. Holder should be able to make a mark-to-market election, but no assurance can be given. If we are a PFIC
and, in a later year, cease to be a PFIC, a U.S. holder who has made a valid mark-to-market election would not be required to continue to include in income amounts determined under the mark-to-market regime, though the mark-to-market election would
remain in effect and would continue to apply if we were treated as a PFIC in a subsequent taxable year.



In addition to the special PFIC tax regime, dividends paid on shares of a PFIC are not eligible for the reduced (maximum 15%) rate of taxation of dividends received
by non-corporate U.S. holders on shares of qualifying corporations and would be taxed at the higher rates applicable to other items of ordinary income. If we are a PFIC for any taxable year, U.S. holders who acquire shares or ADSs from decedents
could be denied the step-up in the tax basis for such shares or ADSs, which would otherwise have been available.



If you own shares or ADSs during any year in which we are a PFIC, you must file IRS Form 8621 with your annual United States federal income tax return for each year
in which you own shares or ADSs, even if we subsequently would not be considered a PFIC.



U.S. holders should consult their own tax advisors regarding the application of the PFIC rules to the shares or ADSs and the availability and advisability of making an election to avoid the adverse U.S. federal income tax
consequences of the interest charge regime should we be classified as a PFIC for any taxable year.



U.S. Information Reporting and Backup Withholding



Dividend payments with respect to shares or ADSs and proceeds from the sale, exchange, redemption, or other disposition of shares or ADSs may be subject to
information reporting to the IRS and possible U.S. backup withholding. Certain exempt recipients (such as corporations) are not subject to these information reporting requirements. Backup withholding will also not apply to a holder who furnishes a
correct taxpayer identification number or certificate of foreign status and makes any other required certification. U.S. persons who are required to establish their exempt status generally must provide IRS Form W-9 (Request for Taxpayer
Identification Number and Certification).



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Backup withholding is not an additional tax. Amounts withheld as backup withholding may be credited against a
holders U.S. federal income tax liability, and a holder may obtain a refund of any excess amounts withheld by filing the appropriate claim for refund with the IRS and furnishing any required information.



Documents on Display



We are subject to the informational requirements of the Securities Exchange Act of 1934, as amended. In accordance with these
requirements, we file reports and other information with the Securities and Exchange Commission. However, as we are a foreign private issuer, we and our shareholders are exempt from some of the Exchange Act reporting requirements. The reporting
requirements that do not apply to us or our shareholders include the proxy solicitation rules and Section 16 short-swing profit reporting for our officers and directors and for holders of more than 10% of our shares. In addition, we are not
required to file annual, quarterly or current reports and financial statements with the SEC as frequently or as promptly as U.S. companies whose securities are registered under the Exchange Act. However, we will file with the SEC, as long as we are
required to do so, within 180 days after the end of each fiscal year, an annual report on Form 20-F containing financial statements audited by an independent registered public accounting firm. We also intend to file periodic reports on Form 6-K.
These materials, including this annual report and the exhibits thereto, may be inspected and copied at the Commissions Public Reference Room at 450 Fifth Street, N.W., Washington, D.C. 20549. Copies of the materials may be obtained from the
Public Reference Room of the Commission at 450 Fifth Street, N.W., Washington, D.C. 20549 at prescribed rates. The public may obtain information on the operation of the Commissions Public Reference Room by calling the Commission in the United
States at 1-800-SEC-0330. Our Securities and Exchange Commission filings are also available over the Internet at the Securities and Exchange Commissions website at http://www.sec.gov.



Item 11. Quantitative and Qualitative Disclosures About Market Risk.



Our main exposure to market risk is limited to interest rate and
currency exchange rate risks.



Interest Rate Risk



Our investment portfolio is subject to interest rate risk and its value will decrease
if market interest rates increase. The primary objective of our investment activities is to preserve capital. To minimize risk, we maintain a portfolio of cash, cash equivalents, and short-term, long-term and restricted investments in a variety of
interest-bearing instruments, including a bond fund, high-grade European and United States fixed and variable rate corporate bonds and money market funds. As a general policy, we do not invest in equity securities for cash management purposes. Any
equity securities in other companies that we own were acquired as part of licensing agreements. Since our investments are short term in duration (i.e. maturities of 3 years or less), we believe that an immediate 10% change in market interest rates
would not be material to our financial condition or results of operations.



Currency
Exchange Rate Risks



Our results of operations and financial
condition are also subject to exchange rate risks. Fluctuations between the euro and the U.S. dollar can affect our financial results. The U.S. dollar denominated proportion of our revenues and operating costs can vary from year to year. In 2007, a
significant amount of our revenues and expenses was denominated in U.S. dollars. Additionally, we hold cash in the form of U.S. dollars and our investment portfolio includes some marketable securities denominated in U.S. dollars to fund our U.S.
operations. Accordingly, any appreciation of the euro against the dollar would have the effect of reducing our reported revenues and reducing our reported expenses and vice versa. We do not, however, hold any derivative financial instruments to
protect us from the exchange rate risk associated with the U.S. dollar and the euro. A significant portion of other



115



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##### Table of Contents

income and expense relates to foreign currency gains and losses on accounts receivables, accounts payable and cash. Other income (expense), net was (0.5) million for the year ended December 31, 2007 compared with (2.3) million for the year ended December 31, 2006.



We estimated that it could be reasonably possible for there to be a 10% fluctuation in the currency exchange rate. If the value of the US dollar to Euro decreased 10% then our net loss before tax would increase by 349 thousand and 1,008 thousand for the years ended December 31, 2007 and 2006,
respectively.



Item 12. Description of Securities Other
than Equity Securities.



Not applicable.



PART II



Item 13. Defaults, Dividend Arrearages and Delinquencies.



None.



Item 14. Material Modifications to the Rights of Security Holders and Use of Proceeds.



None.



Item 15. Controls and Procedures.



(a) GPC Biotechs chief executive officer and chief financial officer, after evaluating the effectiveness of our disclosure controls and procedures (as defined
in Exchange Act Rule 13a-15(e)) as of the end of the period covered by this Form 20-F, have concluded that, as of such date, our disclosure controls and procedures were effective to ensure that information required to be disclosed by GPC Biotech in
the reports that it files or submits under the Exchange Act is recorded, processed, summarized and reported within the time periods specified in the Securities and Exchange Commissions rules and forms.



(b) Report of GPC Biotech Management on Internal Control Over Financial
Reporting:    GPC Biotechs Management Board are responsible for establishing and maintaining a system of internal control over financial reporting that provides reasonable assurance regarding the reliability of
financial reporting and the preparation and fair presentation of its consolidated financial statements for external purposes in accordance with U.S. generally accepted accounting principles.



Internal control over financial reporting cannot provide absolute assurance due to its
inherent limitations. Because of such limitations, internal control over financial reporting cannot prevent or detect all misstatements, whether unintentional errors or fraud. However, these inherent limitations are known features of the financial
reporting process, therefore, it is possible to design into the process safeguards to reduce, though not eliminate, this risk. Accordingly, the system of internal control over financial reporting is designed to provide reasonable assurance with
respect to financial statement preparation and presentation. Also, projections of any evaluation of effectiveness to future periods are subject to the risk that controls may become inadequate because of changes in conditions, or that the degree of
compliance with the policies or procedures may deteriorate.



GPC Biotech
management assessed the effectiveness of the Companys internal control over financial reporting as of December 31, 2007. In making this assessment, it used the criteria established in the Internal ControlIntegrated Framework issued
by the Committee of Sponsoring Organizations of the Treadway Commission (COSO). Based on this assessment, management has concluded that, as of December 31, 2007, GPC Biotechs internal control over financial reporting is effective based on
those criteria.



116



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##### Table of Contents

The Companys independed registered public accountants, Ernst & Young AG,
Wirtschaftsprüfungsgesellschaft Steuerberatungsgesellschaft, audited the consolidated financial statements included in this Annual Report on Form 20-F. In addition, the effectiveness of the Companys internal control over financial
reporting has been audited by Ernst & Young, as stated in their report appearing below, which expresses an unqualified opinion on the effectiveness of the Companys internal control over financial reporting as of December 31,
2007.



(c) See report of Ernst & Young AG,
Wirtschaftsprüfungsgesellschaft Steuerberatungsgesellschaft, an independent registered public accounting firm, included under Item 18. Financial Statements on page F-3.



(d) Discussion on significant or material changes in internal control over financial
reporting that occurred during the reported year.



Changes in Internal
Control over Financial Reporting and Remediation of Material Weakness in Internal Control over Financial Reporting during 2007.As described in Footnote 2 to consolidated financial statements beginning on page F-9, the
Company made an error in application of the requirements of SFAS 123 (R) during the first nine months of 2007 and in 2006 with regard to estimation of the requisite service period used to recognize share-based compensation expense over
time. Based on this determination, the Company was required to adjust previously reported share-based compensation expense. The net impact of the misapplication of this accounting standard was an overstatement of share-based compensation expense by
approximately (1) 2,018,000 for the 1st quarter 2007 (including a reduction of expense applicable to 2006 that was determined by management to be immaterial
to both 2006 and 2007 interim and annual periods); (2) 1,538,000 for the 2nd quarter 2007; and (3) 1,940,000 for the 3rd quarter 2007. The aggregate effect was considered material to the Companys 2007 interim financial statements.



Management concluded that this error in estimating the requisite service period
represented a material weakness in the Companys internal control over financial reporting during the first nine months of 2007. In the fourth quarter of 2007 and before December 31, 2007, management performed the following actions in
response to the identified material weakness:



| |  | Increased the expertise of its finance and accounting staff by training existing staff and supplementing that staff with others with relevant knowledge to ensure GAAP compliance as it relates
to accounting for stock-based compensation.
| |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  | Performed certain technical computations to estimate the requisite service period for the equity awards and conformed existing accounting policies with the relevant provisions of SFAS 123
(R).
| |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  | Recorded appropriate adjusting entries in the fourth quarter of 2007 to properly reduce the previously recorded stock-based compensation expense during the first three quarters of 2007, and
provided comprehensive disclosure of the adjustments to quarterly financial statements in the annual consolidated financial statements.
| |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



The effectiveness of these remediation actions was tested and validated by management as part of its annual assessment on the effectiveness of internal controls
over financial reporting for the fiscal year 2007. As a result of the remediation actions, the above material weakness did not exist as of December 31, 2007.



Due to the fact that the material weakness was remediated as part of the internal control process prior to the end of the fiscal year,
the Companys management concluded that its internal control over financial reporting was effective as of December 31, 2007.



117



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Going forward, the Company will continue to retain and utilize the services of third parties including valuation
professionals, as well as accounting consultants to assist the Company in performing quarterly calculations of its stock-based compensation expense and assist in supplementing the Companys finance team in applying the more complex aspects of
accounting for share-based payments. The results of calculations and accounting conclusions will be more timely and thoroughly detail reviewed and approved by management.



Except for the matter described above, there have been no other changes in the Companys internal controls over financial reporting that have
materially affected, or are reasonably likely to materially affect our internal control over financial reporting.



Item 16A. Audit Committee Financial Expert.



Our Supervisory Board has determined that Mr. James Frates, a member of our Supervisory Board and Chairman of our Audit Committee, meets the requirements of an
audit committee financial expert and the independence requirements as defined in the Nasdaq listing standards.



Item 16B. Code of Ethics.



The company has adopted a code of ethics applicable to the companys principal executive officer and principal financial officer. This code of ethics is contained within the companys code of conduct which can be
found at the companys website at www.gpc-biotech.com. Information found at this website is not incorporated by reference into this document.



Item 16C. Principal Accountant Fees and Services.



Audit Fees, Audit-Related Fees, Tax Fees and All Other Fees



Fees billed us for professional services by our principal accountant during the fiscal years 2007 and 2006 were as follows:



|                   |  |                     |  |     
|------------------ |  | ------------------- |  | ----
|Type of fees       |  | 2007                |  | 2006
|                   |  | (in thousands of )
|Audit fees         |  | 746                 |  | 217 
|Audit related fees |  | 106                 |  | 212 
|Tax fees           |  | 12                  |  | 19  
|All other fees     |  | 1                   |  | 1   
|                   |  |                    
|Total              |  | 865                 |  | 449 
|                   |  |                    



No services falling under the
de minimis exception of paragraph (c)(7)(i)(c) of Rule 2-01 of Regulation S-X were provided to us by Ernst & Young in 2005 and 2006.



Audit Fees



Audit Fees are defined as the fees for standard audit work that needs to be performed each year in order to issue opinions on our consolidated financial statements
and internal controls over financial reporting (the latter as of December 31, 2007), and to issue reports on local statutory financial statements. Also included are services that can only be provided by our auditor, such as auditing of
nonrecurring transactions and implementation of new accounting policies, pre-issuance reviews of quarterly financial results, consents and comfort letters and any other audit services required for US Securities and Exchange Commission or other
regulatory filings.



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Audit-Related Fees



Audit-Related Fees include fees for those other assurance services provided by the independent auditor but not restricted to those
that can only be provided by the auditor signing the audit report. They comprise amounts for the review of the effectiveness of certain of our internal controls over financial reporting (performed prior to 2007) and consultations regarding new
accounting pronouncements.



Tax
Fees



Tax Fees represent fees for tax compliance, tax
returns, assistance with historical tax matters and other services.



All Other Fees



All Other Fees
represent conference and seminar costs in the finance area.



Pre-approval policies and
procedures



Our Audit Committee has adopted rules of procedures,
which include policies and procedures for the pre-approval of audit and non-audit services rendered by our independent public accountants. Pre-approval may be given as part of the Audit Committees approval of the scope of the engagement of our
independent auditor or on an individual basis. The pre-approval of services may be delegated to one or more of the Audit Committees members, but the decision must be presented to the full Audit Committee at its next scheduled meeting. The
rules of procedure prohibit retention of the independent public accountants to perform the prohibited non-audit functions defined in Section 201 of the Sarbanes-Oxley Act or the rules of the SEC, and also consider whether proposed services are
compatible with the independence of the public accountants. All fees incurred described in this Item 16C have been approved in accordance with these policies and procedures.



Item 16D. Exemptions from the Listing Standards for Audit Committees.



None.



Item 16E. Purchases of Equity Securities by the Issuer and Affiliated Purchasers.



Not applicable.



PART III



Item 17. Financial Statements.



We have responded to Item 18 in lieu of responding to this item.



Item 18. Financial Statements.



See our consolidated financial statements beginning at page F-1.



Under a regulation adopted by the European and German Parliaments, our consolidated financial statements are also being prepared in accordance with International
Financial Reporting Standards (IFRS) in addition to U.S. GAAP.



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Item 19. Exhibits.



|              |  |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
|------------- |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|ExhibitNumber |  | Description                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
|1             |  | Articles of Association of GPC Biotech AG (English translation).                                                                                                                                                                                                                                                                                                                                                                                                                              
|              | 
|2.1           |  | Form of Deposit Agreement between GPC Biotech, The Bank of New York, as depositary, and all registered holders and beneficial owners from time to time of American Depositary Receipts issued thereunder,
including the form of American Depositary Receipt.*                                                                                                                                                                                                                                 
|              | 
|2.2           |  | The total amount of long-term debt securities GPC Biotech authorized under any instrument does not exceed 10% of the total assets of the Company and its subsidiaries on a consolidated basis. GPC
Biotech agrees to furnish to the Securities and Exchange Commission, upon its request, a copy of any instrument defining the rights of holders of long-term debt of GPC Biotech or its subsidiaries for which consolidated or unconsolidated financial
statements are required to be filed.
|              | 
|4.1           |  | Co-Development and License Agreement, dated September 30, 2002, by and between NeoTherapeutics, Inc. and GPC Biotech AG.*                                                                                                                                                                                                                                                                                                                                                                     
|              | 
|4.2           |  | Collaboration and License Agreement, dated April 15, 1999, by and between GPC AG-Genome Pharmaceuticals Corporation and MorphoSys AG.*                                                                                                                                                                                                                                                                                                                                                        
|              | 
|4.3           |  | Amendment to Collaboration and License Agreement, dated December 4, 2000, by and between GPC Biotech AG (formerly GPC AG-Genome Pharmaceuticals Corporation) and MorphoSys AG.*                                                                                                                                                                                                                                                                                                               
|              | 
|4.4           |  | Amendment to Collaboration and License Agreement, dated February 23, 2004, by and between GPC Biotech AG (formerly GPC AG-Genome Pharmaceuticals Corporation) and MorphoSys AG.*                                                                                                                                                                                                                                                                                                              
|              | 
|4.5           |  | License Agreement, effective as of June 25th, 2007 by and between GPC Biotech AG and Yakult Honsha Co. Ltd.(1)                                                                                                                                                                                                                                                                                                                                                                                
|              | 
|4.6           |  | Co-Development and License Agreement by and between GPC Biotech AG and Pharmion GmbH, dated December 19, 2005.(1)***                                                                                                                                                                                                                                                                                                                                                                          
|              | 
|4.7           |  | Supply Agreement by and between GPC Biotech AG and Pharmion GmbH, dated December 19, 2005.(1)***                                                                                                                                                                                                                                                                                                                                                                                              
|              | 
|4.8           |  | Asset Purchase Agreement between GPC Biotech AG (as successor to Blitz 05-001 GmbH) and Rechtsanwalt Dr. Joseph Füchsl as Insolvency Receiver of Axxima Pharmaceuticals AG, dated March 2, 2005.***                                                                                                                                                                                                                                                                                           
|              | 
|4.9           |  | Service Agreement (Vorstandsvertrag) with Dr. Bernd Seizinger dated March 1, 2007 (English translation).****                                                                                                                                                                                                                                                                                                                                                                                  
|              | 
|4.10          |  | Amendment to the Service Agreement with Dr. Bernd Seizinger, dated December 14, 2007.                                                                                                                                                                                                                                                                                                                                                                                                         
|              | 
|4.11          |  | Supplemental Agreement to the Service Agreement with Dr. Bernd Seizinger, dated April 16, 2008                                                                                                                                                                                                                                                                                                                                                                                                
|              | 
|4.12          |  | Service Agreement (Vorstandsvertrag) with Dr. Mirko Scherer dated March 1, 2007 (English translation).****                                                                                                                                                                                                                                                                                                                                                                                    
|              | 
|4.13          |  | Service Agreement (Vorstandsvertrag) with Dr. Sebastian Meier-Ewert dated May 1, 2007 (English translation).****                                                                                                                                                                                                                                                                                                                                                                              
|              | 
|4.14          |  | Service Agreement (Vorstandsvertrag) with Dr. Elmar Maier dated May 1, 2007 (English translation).****                                                                                                                                                                                                                                                                                                                                                                                        



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|     |  |                                                                                                                                                                                                                                                        
|---- |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|     | 
|4.15 |  | Service Agreement (Vorstandsvertrag) with Dr. Torsten Hombeck dated February 12, 2008 (English translation).                                                                                                                                           
|     | 
|4.16 |  | Stock Option Plan 2007 (English translation).****                                                                                                                                                                                                      
|     | 
|4.17 |  | Stock Option Plan 2006 (English translation).                                                                                                                                                                                                         
|     | 
|4.18 |  | Stock Option Plan 2005 (English translation).***                                                                                                                                                                                                       
|     | 
|4.19 |  | Stock Option Plan 2004 (English translation).**                                                                                                                                                                                                        
|     | 
|4.20 |  | Stock Option Plan 2002 (English translation).*                                                                                                                                                                                                         
|     | 
|4.21 |  | Stock Option Plan 2001 (English translation).*                                                                                                                                                                                                         
|     | 
|4.22 |  | Stock Option Plan 2000 (English translation).*                                                                                                                                                                                                         
|     | 
|4.23 |  | Option Terms dated September 1999 (English translation).*                                                                                                                                                                                              
|     | 
|4.24 |  | Option Terms for 1997 (English translation).*                                                                                                                                                                                                          
|     | 
|4.25 |  | 2007 Incentive Stock Option Plan.****                                                                                                                                                                                                                  
|     | 
|4.26 |  | 2006 Incentive Stock Option Plan.                                                                                                                                                                                                                     
|     | 
|4.27 |  | 2005 Incentive Stock Option Plan.***                                                                                                                                                                                                                   
|     | 
|4.28 |  | 2004 Incentive Stock Option Plan.***                                                                                                                                                                                                                   
|     | 
|4.29 |  | 2002 Incentive Stock Option Plan.*                                                                                                                                                                                                                     
|     | 
|4.30 |  | 2001 Incentive Stock Option Plan.*                                                                                                                                                                                                                     
|     | 
|4.31 |  | 2000 Incentive Stock Option Plan.*                                                                                                                                                                                                                     
|     | 
|4.32 |  | 1999 U.S. Incentive Stock Option Plan.*                                                                                                                                                                                                                
|     | 
|4.33 |  | Convertible Bonds Terms and Conditions for Members of Management Bodies of the Company and its affiliated subsidiary companies (nachgeordnete verbundene Unternehmen), dated May 25, 2007.****                                                         
|     | 
|4.34 |  | Convertible Bonds Terms and conditions for members of the management bodies of GPC Biotech and affiliated subsidiary companies in Germany and abroad, dated May 24, 2006.                                                                             
|     | 
|4.35 |  | Convertible Bonds Terms and Conditions for executives (Führungskräfte) as well as employees and consultants of the Company and its affiliated subsidiary companies (nachgeordnete
verbundene Unternehmen) in Germany and abroad, dated June 8, 2005.***
|     | 
|4.36 |  | Convertible Bonds Terms and Conditions for Managers of the Company and Management Bodies and Managers of Second-Tier Domestic and Foreign Affiliated Enterprises dated September 30,
2004.**                                                           
|     | 
|4.37 |  | Convertible Bonds Terms and Conditions for Managers of the Company and Management Bodies and Managers of Second-Tier Domestic and Foreign Affiliated Enterprises as well as for Consultants dated May 21,
2003.*                                       
|     | 
|4.38 |  | Convertible Bonds Terms and Conditions for Managers of the Company and Management Bodies and Managers of Second-Tier Domestic and Foreign Affiliated Enterprises as well as for Consultants dated May 20,
2003.*                                       
|     | 
|4.39 |  | Convertible Bonds Terms and Conditions for Members of the Supervisory Board dated October 9, 2001 (English translation).*                                                                                                                              
|     | 
|4.40 |  | Convertible Bonds Terms and Conditions for Members of the Supervisory Board dated May 26, 2003 (English translation).*                                                                                                                                 



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|     |  |                                                                                                                                                                                            
|---- |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|     | 
|4.41 |  | Terms and Conditions for Stock Appreciation Rights granted to members of the Supervisory Board in 2006.***                                                                                 
|     | 
|4.42 |  | Terms and Conditions for Stock Appreciation Rights granted to members of the Supervisory Board in 2005.***                                                                                 
|     | 
|4.43 |  | Terms and Conditions for Stock Appreciation Rights granted to members of the Supervisory Board in 2004.**                                                                                  
|     | 
|4.44 |  | Transfer Agreement between Credit Suisse First Boston International, Dr. Bernd Seizinger and GPC Biotech AG dated November 15, 2001.*                                                      
|     | 
|8    |  | Subsidiaries of the Registrant.*                                                                                                                                                           
|     | 
|12.1 |  | Certification of the Principal Executive Officer pursuant to Section 302 of the Sarbanes-Oxley Act of 2002.                                                                                
|     | 
|12.2 |  | Certification of the Principal Financial Officer pursuant to Section 302 of the Sarbanes-Oxley Act of 2002.                                                                                
|     | 
|13.1 |  | Certification of the Principal Executive Officer and the Principal Financial Officer in accordance with 18 U.S.C. Section 1350 as adopted by Section 906 of the Sarbanes-Oxley Act of
2002.
|     | 
|14.1 |  | Consent of Ernst & Young AG, Wirtschaftsprüfungsgesellschaft Steuerberatungsgesellschaft, independent registered public accounting firm.                                                   



|* | Incorporated by reference from the Registrants Form F-1 (No. 333-116303) filed June 9, 2004.
|- | ---------------------------------------------------------------------------------------------

|** | Incorporated by reference from the Registrants Form 20-F (No. 001-117629) filed March 31, 2005.
|-- | ------------------------------------------------------------------------------------------------

|*** | Incorporated by reference from the Registrants Form 20-F (No. 000-50825) filed April 3, 2006.
|--- | ----------------------------------------------------------------------------------------------

|**** | Incorporated by reference from the Registrants Form 20-F (No. 000-50825) filed June 21, 2007.
|---- | ----------------------------------------------------------------------------------------------

| | Incorporated by reference from the Registrants Form S-8 (No. 333-136932) filed on August 28, 2006).
|- | ----------------------------------------------------------------------------------------------------

|(1) | Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the
SEC pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended.
|--- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



122



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SIGNATURES



Pursuant to the requirements of the Securities Exchange Act, as amended, the registrant certifies that it meets all of the requirements for filing this annual report on Form 20-F
and has duly caused this annual report to be signed on its behalf by the undersigned, thereunto duly authorized.



GPC BIOTECH AGBy:

/s/ BERND R. SEIZINGERName:

Bernd R. SeizingerTitle:

Chief Executive OfficerBy:

/s/ TORSTEN HOMBECKName:

Torsten HombeckTitle:

Chief Financial Officer




Dated June 30, 2008



123



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##### Table of Contents

GPC Biotech AG



Consolidated Financial Statements



Contents



|                                                           |  |    
|---------------------------------------------------------- |  | ---
|Report of Independent Registered Public Accounting Firm    |  | F-2
|Consolidated Balance Sheet                                 |  | F-5
|Consolidated Statements of Operations                      |  | F-6
|Consolidated Statements of Cash Flows                      |  | F-7
|Consolidated Statements of Changes in Shareholders Equity |  | F-8
|Notes to Consolidated Financial Statements                 |  | F-9



F-1



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##### Table of Contents

Report of Independent Registered Public Accounting Firm



The Supervisory Board and Shareholders of GPC Biotech AG



We have audited the accompanying consolidated balance sheets of GPC Biotech AG as of
December 31, 2007 and 2006, and the related consolidated statements of operations, changes in shareholders equity, and cash flows for each of the three years in the period ended December 31, 2007. These financial statements are the
responsibility of the Companys management. Our responsibility is to express an opinion on these financial statements based on our audits.



We conducted our audits in accordance with the standards of the Public Company Accounting Oversight Board (United States). Those standards require that we plan and perform the
audit to obtain reasonable assurance about whether the financial statements are free of material misstatement. An audit includes examining, on a test basis, evidence supporting the amounts and disclosures in the financial statements. An audit also
includes assessing the accounting principles used and significant estimates made by management, as well as evaluating the overall financial statement presentation. We believe that our audits provide a reasonable basis for our opinion.



In our opinion, the financial statements referred to above present fairly, in all material respects,
the consolidated financial position of GPC Biotech AG at December 31, 2007 and 2006, and the consolidated results of its operations and its cash flows for each of the three years in the period ended December 31, 2007, in conformity with U.S.
generally accepted accounting principles.



We also have audited, in accordance with the
standards of the Public Company Accounting Oversight Board (United States), GPC Biotech AGs internal control over financial reporting as of December 31, 2007, based on criteria established in Internal ControlIntegrated Framework
issued by the Committee of Sponsoring Organizations of the Treadway Commission and our report dated March 26, 2008 expressed an unqualified opinion thereon.



Munich, March 26, 2008

Ernst
& Young AG

Wirtschaftsprufüngsgesellschaft

Steuerberatungsgesellschaft



|                        |  |                    |  | 
|----------------------- |  | ------------------ |  | 
|/s/ Julie Linn Teigland |  | /s/ Dirk Gallowsky |  | 
|Julie Linn Teigland     |  | Dirk Gallowsky     |  | 



Encl.



F-2



---

##### Table of Contents

Report of Independent Registered Public Accounting Firm



The Supervisory Board and Shareholders of GPC Biotech AG



We have audited GPC Biotech AGs internal control over financial reporting as of December 31,
2007, based on criteria established in Internal Control  Integrated Framework issued by the Committee of Sponsoring Organizations of the Treadway Commission (the COSO criteria). GPC Biotech AGs management is responsible for maintaining
effective internal control over financial reporting, and for its assessment of the effectiveness of internal control over financial reporting included in the accompanying Managements Report on Internal Control over Financial Reporting. Our
responsibility is to express an opinion on the companys internal control over financial reporting based on our audit.



We conducted our audit in accordance with the standards of the Public Company Accounting Oversight Board (United States). Those standards require that we plan and perform the audit
to obtain reasonable assurance about whether effective internal control over financial reporting was maintained in all material respects. Our audit included obtaining an understanding of internal control over financial reporting, assessing the risk
that a material weakness exists, testing and evaluating the design and operating effectiveness of internal control based on the assessed risk, and performing such other procedures as we considered necessary in the circumstances. We believe that our
audit provides a reasonable basis for our opinion.



A companys internal control
over financial reporting is a process designed to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting
principles. A companys internal control over financial reporting includes those policies and procedures that (1) pertain to the maintenance of records that, in reasonable detail, accurately and fairly reflect the transactions and dispositions
of the assets of the company, (2) provide reasonable assurance that transactions are recorded as necessary to permit preparation of financial statements in accordance with generally accepted accounting principles, and that receipts and expenditures
of the company are being made only in accordance with authorizations of management and directors of the company; and (3) provide reasonable assurance regarding prevention or timely detection of unauthorized acquisition, use, or disposition of the
companys assets that could have a material effect on the financial statements.



F-3



---

##### Table of Contents

|                                                                             |  |       
|---------------------------------------------------------------------------- |  | ------
|Ernst & Young AG Wirtschaftsprüfungsgesellschaft Steuerberatungsgesellschaft |  | Page 2



Because of its inherent limitations, internal
control over financial reporting may not prevent or detect misstatements. Also, projections of any evaluation of effectiveness to future periods are subject to the risk that controls may become inadequate because of changes in conditions, or that
the degree of compliance with the policies or procedures may deteriorate.



In our
opinion, GPC Biotech AG maintained, in all material respects, effective internal control over financial reporting as of December 31, 2007, based on the COSO criteria.



We also have audited, in accordance with the standards of the Public Company Accounting Oversight Board (United States), the consolidated balance
sheets of GPC Biotech AG as of December 31, 2007 and 2006, and the related consolidated statements of operations, changes in shareholders equity, and cash flows for each of the three years in the period ended December 31, 2007 and our report
dated March 26, 2008 expressed an unqualified opinion thereon.



Munich, March 26, 2008

Ernst & Young AG

Wirtschaftsprüfungsgesellschaft

Steuerberatungsgesellschaft



|                        |  |                    |  | 
|----------------------- |  | ------------------ |  | 
|/s/ Julie Linn Teigland |  | /s/ Dirk Gallowsky |  | 
|Julie Linn Teigland     |  | Dirk Gallowsky     |  | 



F-4



---

##### Table of Contents

GPC Biotech AG

Consolidated Balance Sheets



|                                                                                                                                 |  |                                                  |   |  |                   |  
|-------------------------------------------------------------------------------------------------------------------------------- |  | ------------------------------------------------ | - |  | ----------------- | -
|                                                                                                                                 |  | December 31, 2007                                |   |  | December 31, 2006 |  
|                                                                                                                                 |  | (in thousand , except share and per share data) |  
|Assets                                                                                                                           |  |                                                  |   |  |                   |  
|Current assets:                                                                                                                  |  |                                                  |   |  |                   |  
|Cash and cash equivalents                                                                                                        |  | 49,681                                           |   |  | 38,336            |  
|Marketable securities and short-term investments                                                                                 |  | 14,077                                           |   |  | 57,186            |  
|Accounts receivable                                                                                                              |  | 984                                              |   |  | 11                |  
|Accounts receivable, related party                                                                                               |  | -                                                |   |  | 395               |  
|Prepaid expenses                                                                                                                 |  | 874                                              |   |  | 1,299             |  
|Other current assets                                                                                                             |  | 2,229                                            |   |  | 2,970             |  
|Restricted Cash                                                                                                                  |  | 1,269                                            |   |  | -                 |  
|                                                                                                                                 |  |                                                  |   |  |                   |  
|Total current assets                                                                                                             |  | 69,114                                           |   |  | 100,197           |  
|Property and equipment, net                                                                                                      |  | 3,070                                            |   |  | 4,259             |  
|Intangible assets, net                                                                                                           |  | 164                                              |   |  | 405               |  
|Other assets, non-current                                                                                                        |  | 851                                              |   |  | 1,127             |  
|Restricted cash                                                                                                                  |  | 187                                              |   |  | 1,531             |  
|                                                                                                                                 |  |                                                  |   |  |                   |  
|Total assets                                                                                                                     |  | 73,386                                           |   |  | 107,519           |  
|                                                                                                                                 |  |                                                  |   |  |                   |  
|Liabilities and shareholders equity                                                                                             |  |                                                  |   |  |                   |  
|Current liabilities:                                                                                                             |  |                                                  |   |  |                   |  
|Accounts payable                                                                                                                 |  | 2,826                                            |   |  | 2,262             |  
|Accrued expenses and other current liabilities                                                                                   |  | 10,445                                           |   |  | 14,346            |  
|Current portion of deferred revenue, related party                                                                               |  | -                                                |   |  | 896               |  
|Current portion of deferred revenue                                                                                              |  | 4,332                                            |   |  | 7,240             |  
|                                                                                                                                 |  |                                                  |   |  |                   |  
|Total current liabilities                                                                                                        |  | 17,603                                           |   |  | 24,744            |  
|                                                                                                                                 |  |                                                 
|Deferred revenue, related party, net of current portion                                                                          |  | -                                                |   |  | -                 |  
|Deferred revenue, net of current portion                                                                                         |  | 13,989                                           |   |  | 9,103             |  
|Convertible bonds                                                                                                                |  | 3,191                                            |   |  | 3,108             |  
|Accrued loss on sublease contract                                                                                                |  | -                                                |   |  | 3,389             |  
|Shareholders equity:                                                                                                            |  |                                                  |   |  |                   |  
|Ordinary shares,  1 non-par,
notional value shares authorized: 70,383,150 at December 31, 2007 and 62,695,630 December 31,
2006 |  |                                                  |   |  |                   |  
|shares issued and outstanding: 36,836,853 at December 31, 2007 and 33,895,444 at December 31, 2006                               |  | 36,837                                           |   |  | 33,895            |  
|Subscribed Shares                                                                                                                |  | -                                                |   |  | 334               |  
|Additional paid-in capital                                                                                                       |  | 369,521                                          |   |  | 328,171           |  
|Accumulated other comprehensive loss                                                                                             |  | (5,040                                           | ) |  | (1,755            | )
|Accumulated deficit                                                                                                              |  | (362,715                                         | ) |  | (293,470          | )
|                                                                                                                                 |  |                                                  |   |  |                   |  
|Total shareholders equity                                                                                                       |  | 38,603                                           |   |  | 67,175            |  
|                                                                                                                                 |  |                                                  |   |  |                   |  
|Total liabilities and shareholders equity                                                                                       |  | 73,386                                           |   |  | 107,519           |  
|                                                                                                                                 |  |                                                  |   |  |                   |  



See accompanying notes to
consolidated financial statements



F-5



---

##### Table of Contents

GPC Biotech AG

Consolidated Statements of Operations



|                                                                    |  |                                                  |   |  |            |   |  |            |  
|------------------------------------------------------------------- |  | ------------------------------------------------ | - |  | ---------- | - |  | ---------- | -
|                                                                    |  | Year ended December 31,                          |  
|                                                                    |  | 2007                                             |   |  | 2006       |   |  | 2005       |  
|                                                                    |  | (in thousand , except share and per share data) |  
|Collaborative revenues (a)                                          |  | 18,022                                           |   |  | 22,252     |   |  | 9,341      |  
|Grant revenues                                                      |  | 293                                              |   |  | 422        |   |  | -          |  
|                                                                    |  |                                                  |   |  |            |   |  |            |  
|Total revenues                                                      |  | 18,315                                           |   |  | 22,674     |   |  | 9,341      |  
|Research and development expenses                                   |  | 51,437                                           |   |  | 64,707     |   |  | 55,684     |  
|General and administrative expenses                                 |  | 39,199                                           |   |  | 23,834     |   |  | 20,590     |  
|In process research and development                                 |  | -                                                |   |  | -          |   |  | 683        |  
|Amortization of intangible assets                                   |  | 218                                              |   |  | 325        |   |  | 417        |  
|                                                                    |  |                                                  |   |  |            |   |  |            |  
|Total operating expenses                                            |  | 90,854                                           |   |  | 88,866     |   |  | 77,374     |  
|                                                                    |  |                                                  |   |  |            |   |  |            |  
|Operating loss                                                      |  | (72,539                                          | ) |  | (66,192    | ) |  | (68,033    | )
|Other (expense) income, net                                         |  | (519                                             | ) |  | (2,316     | ) |  | 2,938      |  
|Interest income                                                     |  | 3,972                                            |   |  | 4,152      |   |  | 2,963      |  
|Interest expense                                                    |  | (159                                             | ) |  | (90        | ) |  | (75        | )
|                                                                    |  |                                                  |   |  |            |   |  |            |  
|                                                                    |  | 3,294                                            |   |  | 1,746      |   |  | 5,826      |  
|Net loss before cumulative effect of change in accounting principle |  | (69,245                                          | ) |  | (64,446    | ) |  | (62,207    | )
|Cumulative effect of change in accounting principle                 |  | -                                                |   |  | 433        |   |  | -          |  
|                                                                    |  |                                                  |   |  |            |   |  |            |  
|Net loss                                                            |  | (69,245                                          | ) |  | (64,013    | ) |  | (62,207    | )
|                                                                    |  |                                                  |   |  |            |   |  |            |  
|Basic and diluted loss per share, in euro                           |  | (1.91                                            | ) |  | (1.95      | ) |  | (2.08      | )
|                                                                    |  |                                                  |   |  |            |   |  |            |  
|Shares used in computing basic and diluted loss per share           |  | 36,181,956                                       |   |  | 32,840,480 |   |  | 29,877,348 |  
|                                                                    |  |                                                  |   |  |            |   |  |            |  
|(a)
Revenues from related party                                     |  |                                                  |   |  |            |   |  |            |  
|Collaborative revenues                                              |  | -                                                |   |  | 7,054      |   |  | 9,095      |  
|                                                                    |  |                                                  |   |  |            |   |  |            |  





See accompanying notes to consolidated financial statements



F-6



---

##### Table of Contents

GPC Biotech AG

Consolidated Statements of Cash Flows



|                                                                                    |  |                         |   |  |         |   |  |         |  
|----------------------------------------------------------------------------------- |  | ----------------------- | - |  | ------- | - |  | ------- | -
|                                                                                    |  | Year ended December 31, |  
|                                                                                    |  | 2007                    |   |  | 2006    |   |  | 2005    |  
|Cash flows from operating activities:                                               |  | (in thousand )         |  
|Net loss                                                                            |  | (69,245                 | ) |  | (64,013 | ) |  | (62,207 | )
|Adjustment to reconcile net loss to net cash used in operating activities:          |  |                         |   |  |         |   |  |         |  
|Depreciation                                                                        |  | 1,607                   |   |  | 1,532   |   |  | 3,478   |  
|Amortization                                                                        |  | 218                     |   |  | 325     |   |  | 417     |  
|Compensation cost for stock option plans, convertible bonds and SARs                |  | 3,491                   |   |  | 6,938   |   |  | 6,665   |  
|Loss accrual on sublease contract and contract termination fee                      |  | (1,571                  | ) |  | 2,161   |   |  | 2,988   |  
|Cumulative effect of change in accounting principle                                 |  | -                       |   |  | (433    | ) |  | -       |  
|Acquired in-process research and development                                        |  | -                       |   |  | -       |   |  | 683     |  
|Accrued interest income on marketable securities and short term investments         |  | -                       |   |  | 293     |   |  | 478     |  
|Other than temporary impairment on investments                                      |  | -                       |   |  | 390     |   |  | -       |  
|Bond premium amortization                                                           |  | 208                     |   |  | 562     |   |  | 629     |  
|(Gain)/loss on disposal of property and equipment                                   |  | 29                      |   |  | (24     | ) |  | (83     | )
|Impairment of property plant and equipment                                          |  | 897                     |   |  | -       |   |  | -       |  
|Changes in operating assets and liabilities:                                        |  |                         |   |  |         |   |  |         |  
|Accounts receivable, related party                                                  |  | 395                     |   |  | 1,041   |   |  | (430    | )
|Accounts receivable                                                                 |  | (973                    | ) |  | 31,313  |   |  | (31,325 | )
|Other assets, current and non-current                                               |  | 1,272                   |   |  | 548     |   |  | 1,550   |  
|Accounts payable                                                                    |  | 747                     |   |  | 271     |   |  | 1,552   |  
|Deferred revenue, related party                                                     |  | (896                    | ) |  | (5,307  | ) |  | (1,671  | )
|Deferred revenue                                                                    |  | 1,978                   |   |  | (15,259 | ) |  | 31,602  |  
|Other liabilities and accrued expenses                                              |  | (4,876                  | ) |  | 3,040   |   |  | 2,887   |  
|                                                                                    |  |                         |   |  |         |   |  |         |  
|Net cash used in operating activities                                               |  | (66,719                 | ) |  | (36,622 | ) |  | (42,787 | )
|                                                                                    |  |                         |  
|Cash flows from investing activities:                                               |  |                         |   |  |         |   |  |         |  
|Purchases of property, equipment and licenses                                       |  | (1,581                  | ) |  | (1,878  | ) |  | (4,549  | )
|Proceeds from the sale of property and equipment                                    |  | 117                     |   |  | 45      |   |  | 187     |  
|Proceeds from the sale of marketable securities and short-term investments          |  | 42,311                  |   |  | 25,445  |   |  | 35,803  |  
|Purchases of marketable securities and short-term investments                       |  | -                       |   |  | (19,906 | ) |  | (31,408 | )
|                                                                                    |  |                         |   |  |         |   |  |         |  
|Net cash provided by investing activities                                           |  | 40,847                  |   |  | 3,706   |   |  | 33      |  
|                                                                                    |  |                         |  
|Cash flows from financing activities:                                               |  |                         |   |  |         |   |  |         |  
|Proceeds from issuance of shares in asset acquisition                               |  | -                       |   |  | -       |   |  | 10,412  |  
|Proceeds from issuance of shares, net of payments for costs of transaction          |  | 32,633                  |   |  | 36,080  |   |  | -       |  
|Proceeds from issuance of convertible bonds                                         |  | 1,006                   |   |  | 970     |   |  | 580     |  
|Repayment of convertible bonds                                                      |  | (485                    | ) |  | -       |   |  | (8      | )
|Proceeds from subscribed shares and exercise of stock options and convertible bonds |  | 7,261                   |   |  | 4,543   |   |  | 517     |  
|                                                                                    |  |                         |   |  |         |   |  |         |  
|Net cash provided by financing activities                                           |  | 40,415                  |   |  | 41,593  |   |  | 11,501  |  
|Effect on exchange rate changes on cash and cash equivalents                        |  | (3,130                  | ) |  | (835    | ) |  | 1,393   |  
|Changes in restricted cash                                                          |  | (68                     | ) |  | (65     | ) |  | 998     |  
|                                                                                    |  |                         |   |  |         |   |  |         |  
|Net increase (decrease) in cash and cash equivalents                                |  | 11,345                  |   |  | 7,777   |   |  | (28,862 | )
|Cash and cash equivalents at beginning of year                                      |  | 38,336                  |   |  | 30,559  |   |  | 59,421  |  
|                                                                                    |  |                         |   |  |         |   |  |         |  
|Cash and cash equivalents at end of year                                            |  | 49,681                  |   |  | 38,336  |   |  | 30,559  |  
|                                                                                    |  |                         |   |  |         |   |  |         |  
|Supplemental Information:                                                           |  |                         |   |  |         |   |  |         |  
|Cash paid for interest                                                              |  | 159                     |   |  | 94      |   |  | 107     |  
|Non-cash investing and financing activities:                                        |  |                         |   |  |         |   |  |         |  
|Net assets acquired in exchange for shares in connection with asset acquisition     |  | -                       |   |  | -       |   |  | 2,667   |  



See accompanying notes to
consolidated financial statements



F-7



---

##### Table of Contents

GPC Biotech AG

Consolidated Statements of Changes in Shareholders Equity

(in thousand , except share data)



|                                                                  |  |                 |  |                  |  |      |                          |  |         |                                   |  |        |                    |  |          |                          |  |         |  
|----------------------------------------------------------------- |  | --------------- |  | ---------------- |  | ---- | ------------------------ |  | ------- | --------------------------------- |  | ------ | ------------------ |  | -------- | ------------------------ |  | ------- | -
|                                                                  |  | Ordinary shares |  | SubscribedShares |  |      | AdditionalPaid-inCapital |  |         | AccumulatedOtherComprehensiveLoss |  |        | AccumulatedDeficit |  |          | TotalShareholdersEquity | 
|                                                                  |  | Shares          |  | Amount           |  |      |                          |  |        
|Balance at January 1, 2005                                        |  | 28,741,194      |  | 28,741           |  | -    |                          |  | 266,074 |                                   |  | (2,732 | )                  |  | (167,250 | )                        |  | 124,833 |  
|                                                                  |  |                 |  |                  |  |      |                          |  |         |                                   |  |        |                    |  |          |                          |  |         |  
|Components of comprehensive loss:                                 |  |                 |  |                  |  |      |                          |  |         |                                   |  |        |                    |  |          |                          |  |         |  
|Net loss                                                          |  |                 |  |                  |  |      |                          |  |         |                                   |  |        |                    |  | (62,207  | )                        |  | (62,207 | )
|Change in unrealized gain/(loss) on available-for-sale securities |  |                 |  |                  |  |      |                          |  |         |                                   |  | (684   | )                  |  |          |                          |  | (684    | )
|Accumulated translation adjustments                               |  |                 |  |                  |  |      |                          |  |         |                                   |  | 1,323  |                    |  |          |                          |  | 1,323   |  
|                                                                  |  |                 |  |                  |  |      |                          |  |         |                                   |  |        |                    |  |          |                          |  |         |  
|Total comprehensive loss                                          |  |                 |  |                  |  |      |                          |  |         |                                   |  |        |                    |  |          |                          |  | (61,568 | )
|Issuance of shares in asset acquisition                           |  | 1,311,098       |  | 1,311            |  |      |                          |  | 11,768  |                                   |  |        |                    |  |          |                          |  | 13,079  |  
|Exercise of stock options and conversion of convertible bonds     |  | 99,465          |  | 100              |  | -    |                          |  | 424     |                                   |  |        |                    |  |          |                          |  | 524     |  
|Compensation cost for stock options and convertible bonds         |  |                 |  |                  |  |      |                          |  | 6,665   |                                   |  |        |                    |  |          |                          |  | 6,665   |  
|                                                                  |  |                 |  |                  |  |      |                          |  |         |                                   |  |        |                    |  |          |                          |  |         |  
|Balance at December 31, 2005                                      |  | 30,151,757      |  | 30,152           |  | -    |                          |  | 284,931 |                                   |  | (2,093 | )                  |  | (229,457 | )                        |  | 83,533  |  
|                                                                  |  |                 |  |                  |  |      |                          |  |         |                                   |  |        |                    |  |          |                          |  |         |  
|Components of comprehensive loss:                                 |  |                 |  |                  |  |      |                          |  |         |                                   |  |        |                    |  |          |                          |  |         |  
|Net loss                                                          |  |                 |  |                  |  |      |                          |  |         |                                   |  |        |                    |  | (64,013  | )                        |  | (64,013 | )
|Change in unrealized gain/(loss) on available-for-sale securities |  |                 |  |                  |  |      |                          |  |         |                                   |  | 615    |                    |  |          |                          |  | 615     |  
|Accumulated translation adjustments                               |  |                 |  |                  |  |      |                          |  |         |                                   |  | (277   | )                  |  |          |                          |  | (277    | )
|                                                                  |  |                 |  |                  |  |      |                          |  |         |                                   |  |        |                    |  |          |                          |  |         |  
|Total comprehensive loss                                          |  |                 |  |                  |  |      |                          |  |         |                                   |  |        |                    |  |          |                          |  | (63,675 | )
|Cumulative effect of change in accounting principle               |  |                 |  |                  |  |      |                          |  | (433    | )                                 |  |        |                    |  |          |                          |  | (433    | )
|Issuance of shares                                                |  | 2,860,000       |  | 2,860            |  |      |                          |  | 33,220  |                                   |  |        |                    |  |          |                          |  | 36,080  |  
|Exercise of stock options and convertible bonds                   |  | 883,687         |  | 883              |  | 334  |                          |  | 3,515   |                                   |  |        |                    |  |          |                          |  | 4,732   |  
|Compensation cost for stock options and convertible bonds         |  |                 |  |                  |  |      |                          |  | 6,938   |                                   |  |        |                    |  |          |                          |  | 6,938   |  
|                                                                  |  |                 |  |                  |  |      |                          |  |         |                                   |  |        |                    |  |          |                          |  |         |  
|Balance at December 31, 2006                                      |  | 33,895,444      |  | 33,895           |  | 334  |                          |  | 328,171 |                                   |  | (1,755 | )                  |  | (293,470 | )                        |  | 67,175  |  
|                                                                  |  |                 |  |                  |  |      |                          |  |         |                                   |  |        |                    |  |          |                          |  |         |  
|Components of comprehensive loss:                                 |  |                 |  |                  |  |      |                          |  |         |                                   |  |        |                    |  |          |                          |  |         |  
|Net loss                                                          |  |                 |  |                  |  |      |                          |  |         |                                   |  |        |                    |  | (69,245  | )                        |  | (69,245 | )
|Change in unrealized gain/(loss) on available-for-sale securities |  |                 |  |                  |  |      |                          |  |         |                                   |  | (590   | )                  |  |          |                          |  | (590    | )
|Accumulated translation adjustments                               |  |                 |  |                  |  |      |                          |  |         |                                   |  | (2,695 | )                  |  |          |                          |  | (2,695  | )
|                                                                  |  |                 |  |                  |  |      |                          |  |         |                                   |  |        |                    |  |          |                          |  |         |  
|Total comprehensive loss                                          |  |                 |  |                  |  |      |                          |  |         |                                   |  |        |                    |  |          |                          |  | (72,530 | )
|Issuance of shares                                                |  | 1,564,587       |  | 1,565            |  |      |                          |  | 31,068  |                                   |  |        |                    |  |          |                          |  | 32,633  |  
|Exercise of stock options and conversion of convertible bonds     |  | 1,376,822       |  | 1,377            |  | (334 | )                        |  | 6,656   |                                   |  |        |                    |  |          |                          |  | 7,699   |  
|Compensation cost for stock options and convertible bonds         |  |                 |  |                  |  |      |                          |  | 3,626   |                                   |  |        |                    |  |          |                          |  | 3,626   |  
|                                                                  |  |                 |  |                  |  |      |                          |  |         |                                   |  |        |                    |  |          |                          |  |         |  
|Balance at December 31, 2007                                      |  | 36,836,853      |  | 36,837           |  | -    |                          |  | 369,521 |                                   |  | (5,040 | )                  |  | (362,715 | )                        |  | 38,603  |  
|                                                                  |  |                 |  |                  |  |      |                          |  |         |                                   |  |        |                    |  |          |                          |  |         |  



See accompanying notes to
consolidated financial statements



F-8



---

##### Table of Contents

1. Nature of Business and Organization



GPC Biotech AG is a publicly traded biopharmaceutical company focused on discovering,
developing and commercializing new anticancer drugs. GPC Biotech AG (hereafter referred to as GPC Biotech or the Company) is incorporated in the Federal Republic of Germany and has its registered offices and corporate
headquarters in Martinsried/Munich (Germany). Its wholly owned U.S. subsidiary is located in Princeton, New Jersey.



The Companys lead product candidate is satraplatin, an oral platinum-based anticancer agent. In February 2007, the Company completed a New Drug Application
(NDA) submission for satraplatin based on the results of a Phase 3 trial, called the SPARC trial, in second-line hormone refractory prostate cancer. The results showed a statistically significant improvement in progression-free survival. Based on
these results, the Company requested accelerated approval in the U.S. for satraplatin. That submission was accepted by the U.S. Food and Drug Administration (FDA) and granted priority review status. In July 2007, an FDA advisory panel recommended
that the agency await the final overall survival results from the trial before determining if the satraplatin NDA submission was approvable. Based on this recommendation, GPC Biotech withdrew the satraplatin NDA. In late October 2007, the Company
announced that satraplatin did not demonstrate an improvement in overall survival in the total patient population in the SPARC trial.



In Europe, the Companys partner, Pharmion, submitted a Marketing Authorization Application (MAA) for satraplatin in mid-2007. That submission was accepted by
the European Medicines Agency (EMEA) and a decision on the filing is expected in the second half of 2008.



In June 2007, GPC Biotech announced a partnership for satraplatin in Japan with Yakult Honsha Co. Ltd. Under the terms of the agreement, Yakult gained exclusive
commercialization rights to satraplatin for Japan and took the lead in developing the drug in that country.



Following the disappointing overall survival results from the SPARC trial, GPC Biotech began the process of implementing a new strategic plan, which involved
drastically reducing costs and exploring opportunities to combine with or acquire other companies that could complement GPC Biotechs own programs and expand its asset portfolio. In addition, the Company undertook a detailed evaluation of all
existing research and development programs. This included conducting extensive analyses of the SPARC trial survival data to gain a better understanding of the overall survival results; evaluating all ongoing and planned trials with satraplatin to
determine the future development path for this compound; and reviewing all other ongoing research and development programs to determine which ones should be moved forward, partnered or stopped. The Company is continuing to implement this plan.



As a biopharmaceutical company, the Company is subject to risks common
to companies in the biotechnology industry including, but not limited to, product development risks, new technological innovations, protection of proprietary technology, compliance with government regulations, dependence on key personnel, the need
to obtain additional financing, uncertainty of market acceptance of products and product liability.



2. Adjustment of Quarterly Financial Statements



Beginning January 1, 2006, the Company adopted Statement of Financial Accounting Standards No.123(R), Share-Based Payment, (SFAS 123(R)) to account for the Companys share based compensation arrangements. All of
the Companys share compensation plans impose on the beneficiary a holding period, a four-year vesting schedule and certain market-related performance hurdles, all of which have to be met prior to exercising any options.



F-9



---

##### Table of Contents

Under SFAS 123(R), a company whose share based compensation plans feature both a service and a market condition is
required to use a requisite service period for recognizing stock based compensation over time. This requisite service period is determined by identifying the longer of an estimated derived service period and the explicit service period,
(the contractual vesting period). The derived service period is an estimated period that assesses when a beneficiary would actually exercise the instrument, using a Monte Carlo simulation described in greater detail below.



The detailed calculations and requirements of SFAS 123(R) are complex. In the fourth
quarter of 2007, the Company determined that based on SFAS 123(R) it was not able to use the explicit service period but that it had to use the longer derived service period. Based on this determination, the Company was required to adjust previously
reported share-based compensation expense to reduce the amount previously charged to expense and to recognize the related fair value of the awards over the derived service period.



Below is a summary of the adjustments and their impact on the relevant line items (in thousand , except for per share data) for the quarters ended March 31, June 30, September 30 and December 31, 2007:



|                        |  |         |   |  |         |   |  |         |   |  |         |   |  |         |  
|----------------------- |  | ------- | - |  | ------- | - |  | ------- | - |  | ------- | - |  | ------- | -
|                        |  | 2007    |   |  |         |  
|As previously reported  |  | Q1      |   |  | Q2      |   |  | Q3      |   |  | Q4      |   |  | Total   |  
|R&D expense             |  | 13,040  |   |  | 15,527  |   |  | 15,128  |   |  | 7,742   |   |  | 51,437  |  
|G&A expense             |  | 11,023  |   |  | 12,376  |   |  | 13,833  |   |  | 1,967   |   |  | 39,199  |  
|Total operating expense |  | 24,154  |   |  | 27,993  |   |  | 28,980  |   |  | 9,727   |   |  | 90,854  |  
|Operating loss          |  | (20,315 | ) |  | (24,606 | ) |  | (20,063 | ) |  | (7,555  | ) |  | (72,539 | )
|Net loss                |  | (19,157 | ) |  | (23,665 | ) |  | (19,973 | ) |  | (6,450  | ) |  | (69,245 | )
|Loss per share          |  | (0.54   | ) |  | (0.66   | ) |  | (0.55   | ) |  | (0.16   | ) |  | (1.91   | )
|                        |  |         |   |  |        
|As revised              |  | Q1      |   |  | Q2      |   |  | Q3      |   |  | Q4      |   |  | Total   |  
|R&D expense             |  | 12,238  |   |  | 14,976  |   |  | 14,568  |   |  | 9,655   |   |  | 51,437  |  
|G&A expense             |  | 9,807   |   |  | 11,389  |   |  | 12,453  |   |  | 5,550   |   |  | 39,199  |  
|Total operating expense |  | 22,136  |   |  | 26,455  |   |  | 27,040  |   |  | 15,223  |   |  | 90,854  |  
|Operating loss          |  | (18,297 | ) |  | (23,068 | ) |  | (18,123 | ) |  | (13,051 | ) |  | (72,539 | )
|Net loss                |  | (17,139 | ) |  | (22,127 | ) |  | (18,033 | ) |  | (11,946 | ) |  | (69,245 | )
|Loss per share          |  | (0.48   | ) |  | (0.61   | ) |  | (0.50   | ) |  | (0.32   | ) |  | (1.91   | )



Q1 2007 As revised
numbers in the table above include a reduction of share-based compensation expense applicable to 2006 financial statements and determined by management to be immaterial to both 2006 and 2007 interim and annual periods.



3. Summary of Significant Accounting Policies



Basis of Financial Statement Presentation



The accompanying Consolidated Financial Statements present the operations of GPC
Biotech AG and its subsidiary. The Consolidated Financial Statements have been prepared in accordance with accounting principles generally accepted in the United States (U. S. GAAP). Amounts are stated in thousands of Euro ( thousand) except as otherwise indicated.



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Use of Estimates



The preparation of financial statements in conformity with the U. S. GAAP requires the use of estimates and assumptions. These affect the reported amounts of assets
and liabilities and the contingent assets and contingent liabilities at the date of the consolidated financial statements and the reported amounts of revenues and expenses during the reporting period. The most significant assumptions are utilized in
determining values of accruals, tax assets and liabilities, provisions for litigation and restructuring charges. Estimates are also used in applying the revenue recognition policy and accounting for stock-based compensation costs. Actual values may
vary from the estimates. The estimates and assumptions are continually reviewed by management.



Principles of Consolidation



The consolidated
financial statements include the accounts of the Company and its wholly owned subsidiary, GPC Biotech Inc. All significant intercompany transactions and balances have been eliminated.



Cash and Cash Equivalents



In accordance with Statement of Financial Accounting Standards No. 95, Statement of Cash Flows, (SFAS 95), short-term, highly
liquid instruments with a maturity of three months or less that are readily convertible to known amounts of cash are considered cash and cash equivalents. Cash and cash equivalents are carried at cost which approximates their fair values.



Marketable Securities and Short-Term Investments



The Company classifies and accounts for its marketable securities as available-for-sale
in accordance with Statement of Financial Accounting Standards No. 115, Accounting for Certain Investments in Debt and Equity Securities, (SFAS 115). Available-for-sale securities are measured at fair value in the
consolidated balance sheets, with unrealized gains and losses included in accumulated other comprehensive income (loss). All available-for-sale securities are classified as current assets as the funds are highly liquid and are available to meet
working capital needs and to fund current operations.



Other-Than-Temporary
Impairment



In accordance with Financial Accounting Standards
Board (FASB) Staff Position 115-1, The Meaning of Other-Than-Temporary Impairment and Its Application to Certain Investments, (FSP 115-1), available-for-sale marketable securities and investments which incur a decline
in value below cost that is judged to be other than temporary are considered impaired. The Company considers all available evidence such as market conditions and prices, investee-specific factors, and the duration and extent to which fair value is
less than cost in evaluating potential impairment of its marketable securities and investments. Impairments are recognized in earnings in the period in which the decline in value is judged to be other than temporary and a new cost basis in the
marketable security or investment is established.



As a general policy,
the Company does not invest in equity securities for cash management purposes. Any equity securities owned by the Company were acquired as part of licensing agreements.



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Restricted Cash



Restricted cash represents amounts held in interest bearing escrow accounts as security deposits related to facility leases.



Concentration of Credit Risk



The Companys financial instruments that are potentially subject to credit risk
consist primarily of cash and cash equivalents and marketable securities and short-term investments. The Company invests cash not used in current operations in accordance with its investment policy which is limiting investments to those that have
relatively short maturities and that are placed with highly rated issuers. Marketable securities and short-term investments include bonds from corporate issuers. The Company believes its established guidelines for investment of excess cash maintain
preservation of capital and liquidity through its policy on diversification and investment maturity. The maximum loss that could occur if one single bond issuer defaults on its bond obligations would be 10 million as of December 31, 2007.



One collaboration partner, Pharmion, accounted for 16,315,000 of total revenues in 2007 representing 89%, 14,948,000 of total revenues in 2006 representing 66% and 0 (0%) of total revenues in 2005. Another
collaboration partner, ALTANA Pharma, accounted for 1,596,000 of total revenues in 2007 representing 9%, 7,054,000 of total revenues in 2006 representing 31% and 9,095,000 of total revenues in 2005 representing 97%. No other partners or
customers accounted for more than 10% of total revenues in 2007, 2006 or 2005.



Segment Information



Statement of Financial
Accounting Standards No. 131, Disclosures about the Segments of an Enterprise and Related Information, (SFAS 131), establishes standards for the way that public business enterprises report information about operating segments
in annual financial statements and requires that those enterprises report selected information about operating segments in interim financial reports. SFAS No. 131 also establishes standards for related disclosures about the products and
services, geographic areas and major customers.



The Company operates in
one business segment, which primarily focuses on discovery, development and commercialization of anticancer drugs. The Companys revenue is derived primarily from co-development and research collaborations with life science companies.
Additional revenue is derived from governmental grants for specific research and development programs. The results of operations are reported to the Companys chief operating decision-makers on an aggregate basis.



The total book value of long-lived assets located outside of the Companys home
location of Germany was 958,000 and 1,940,000 at December 31, 2007 and
2006, respectively. All of these assets were located in the United States of America.



Revenues from external customers attributed to the Companys home location of Germany were 18,266,000, 22,596,000, and 9,095,000 in the years ended December 31, 2007, 2006 and 2005, respectively. Revenues
from external customers attributed to locations outside of Germany were 49,000, 78,000 and 246,000 in the years ended December 31, 2007, 2006 and 2005, respectively. Revenues are attributed to countries based on the location of the
Companys legal entity that is party to the underlying contract.



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Property and Equipment



Property and equipment are stated at cost less accumulated depreciation and any impairment in value. Property and equipment are depreciated using the straight-line
method over the estimated useful lives of the assets as follows:



|                                        |  |                                       
|--------------------------------------- |  | --------------------------------------
|                                        |  | Estimated Useful Life                 
|Computer equipment and related software |  | 3 years                               
|Office equipment                        |  | 5-10 years                            
|Laboratory equipment                    |  | 5 years                               
|Furniture and fixtures                  |  | 5 years                               
|Leasehold improvements                  |  | Lesser of useful life or life of lease



Intangible Assets



Intangible assets primarily include specifically identified intangible assets acquired
in a business combination and in an asset acquisition and are stated at cost less accumulated amortization and any impairment in value. Amortization of intangible assets is computed using the straight-line method over the estimated useful lives of
the assets.



The estimated useful life of major intangible assets is as
follows:



|                        |  |                      
|----------------------- |  | ---------------------
|                        |  | Estimated Useful Life
|Patents and licenses    |  | 10 years             
|Other intangible assets |  | 5 years              



Impairment of Long-Lived Assets



In accordance with Statement of Financial Accounting Standards
No. 144, Accounting for the Impairment or Disposal of Long-Lived Assets, (SFAS 144), the Company reviews long-lived assets and certain identifiable intangible assets for impairment annually and whenever events or changes in
circumstances indicate that the carrying amount of an asset may not be recoverable. Indicators that result in reviewing our long-lived assets for impairment are, among others, termination of research programs, restructuring programs, equipment
obsolescence, idle equipment, or vacating of facilities. Recoverability of assets to be held and used is measured by a comparison of the carrying amount of an asset to undiscounted future cash flows expected to be generated by the asset. If such
assets are considered to be impaired, the impairment to be recognized is the amount by which the carrying amount of the assets exceeds the fair value of the assets. Estimated fair value is generally based on either appraised value or measured by
discounted estimated future cash flows.



Fair Value of Financial Instruments



The carrying amounts of financial instruments such as cash and
cash equivalents; trade receivable and payable and accrued expenses approximate their fair value due to their short-term nature. Available-for-sale marketable securities are carried at fair value based on quoted market prices. Fair values of
investments are disclosed in Footnote 6, Marketable Securities and Short Term Investments.



Revenue Recognition



The Companys revenues
consist of fees earned from co-development and licensing arrangements, research and development collaboration agreements, and grant revenues. Revenues



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from co-development and licensing agreements and from research and development collaborations agreements generally consist of licensing fees and/or technology access
fees, reimbursement fees, payments from a partner for shared development costs, fees for research and development support, as well as milestone and royalty payments. Revenues from grants generally consist of reimbursements of a portion of expenses
incurred in performing research in specified projects.



The Company
follows the provisions of the Securities and Exchange Commission (SEC) Staff Accounting Bulletin No. 104, Revenue Recognition, (SAB 104), Emerging Issues Task Force Issue No. 00-21,Revenue Arrangements with Multiple
Deliverables, (EITF 00-21), and EITF Issue No. 99-19, Reporting Revenue Gross as a Principal Versus Net as an Agent, (EITF 99-19), for revenue recognition. Applying SAB 104, EITF 00-21 and EITF 99-19 requires
significant management judgments. Circumstances and conditions can change and may cause the amount of revenue recognized in future periods to increase or decrease. The fluctuation of exchange rates will also impact the value of foreign currency
denominated collaborations.



SAB 104: Revenue Recognition



In accordance with SAB 104, revenue is recognized when it is realized or realizable and
earned:



| |  | Persuasive evidence of an arrangement exists
| | - | --------------------------------------------



| |  | Delivery has occurred
| | - | ---------------------



| |  | The monetary consideration is fixed or determinable and collectability is reasonably assured.
| | - | ---------------------------------------------------------------------------------------------



EITF 00-21: Revenue Arrangements with Multiple Deliverables



When evaluating multiple- element arrangements, the Company follows the provisions of EITF 00-21 which addresses when and how an
arrangement involving multiple deliverables should be divided into separate units of accounting. The Companys deliverables include items such as; the transfer of knowledge, transfer of product and involvement in joint steering committees. The
Company analyzes whether an obligation is considered a deliverable using the following criteria:



| |  | obligation is explicitly referred to in a contractual arrangement;
| | - | ------------------------------------------------------------------



| |  | requires distinct action by the Company;
| | - | ----------------------------------------



| |  | if not completed would result in a significant contractual penalty, or
| | - | ----------------------------------------------------------------------



| |  | if included or excluded from the arrangement would cause the arrangement fee to vary by more than an insignificant amount.
| | - | --------------------------------------------------------------------------------------------------------------------------



A multiple-element arrangement is separated into more than one unit of accounting if
all of the following criteria are met:



| |  | The delivered item(s) has value to the client on a stand-alone basis
| | - | --------------------------------------------------------------------



| |  | There is objective and reliable evidence of the fair value of the undelivered item(s); and If the arrangement includes a general right of return relative to the delivered item(s), delivery or
performance of the undelivered item(s) is considered probable and substantially in the control of the company.
| | - | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



If these criteria are not met, the Company accounts for the arrangement as single unit of accounting which would result in revenue being recognized ratably over the
period of the Companys



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substantial continuing involvement or being deferred until the earlier of when SAB104 criteria are met or when the last undelivered element is delivered. If these
criteria are met for each element and there is objective and reliable evidence of fair value for all units of accounting in an arrangement, the Company allocates the arrangement consideration to separate units of accounting based on each units
relative fair value. There may be cases, however, in which there is objective and reliable evidence of fair value of the undelivered item(s) but no such evidence for the delivered item(s). In those cases, the Company employs the residual method to
allocate the arrangement consideration. Under the residual method, the amount of consideration allocated to the delivered item(s) equals the total arrangement consideration less the aggregate fair value of the undelivered item(s).



EITF 99-19: Reporting Revenue Gross as a Principal Versus Net as an Agent



In accordance with the criteria of EITF 99-19, the Company recognizes revenue gross
when it acts as a principal, has discretion to choose suppliers, bears credit risk and performs part of the services required in the transaction. If the above criteria are not met, the Company recognizes revenue net of related costs.



Licensing Arrangements



The Company generally receives non-refundable upfront fees upon signing of a licensing agreement. These fees generally include
licensing fees, technology access fees and initiation fees. All non-refundable upfront fees received or to be received under these arrangements are recognized when SAB 104 revenue recognition criteria are met, ratably over the term of the
agreements, as this is the period over which the license is granted or the Company is substantially and continually involved.



Co-Development Arrangements



Revenue recognized from partners in co-development arrangements is generally based on a fixed-percentage of agreed upon research, development and commercialization
costs incurred by the Company. Revenue from these co-development arrangements are recognized on a gross basis as collaboration revenue in the consolidated statement of operations as the related costs are incurred. If payments are received prior to
the activity having been performed, these amounts are deferred and recognized in future periods when the co-development costs are incurred.



Milestone Payments



Milestone payments are recognized as revenue when the performance obligations, as defined in the contracts, are achieved. Performance obligations typically consist of significant milestones in the life cycle of the related
technology or product candidate, such as initiation of clinical trials, filing for approval with regulatory agencies and approvals by regulatory agencies. These milestone payments are generally tied to a specific performance condition and are
recognized in full when the performance obligation is met. The reaching of a milestone is evidenced by a milestone confirmation letter that is signed and dated by both parties. In the absence of such milestone confirmation, no milestone revenue is
recognized, unless there is other persuasive evidence that the milestone event has been reached and the milestone fee has been earned.



Grant Revenues



Grant revenues from governmental agencies for the support of specific research and development projects are recorded as revenue to the extent the related expenses have been incurred and billed in accordance with the terms of
the grant.



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Research and Development



Research and development (R&D) expenses include salaries, benefits, and other headcount related costs; clinical trial and related clinical manufacturing costs;
contract and other outside service fees; employee stock-based compensation expense; and facilities and overhead costs. R&D expenses consist of independent R&D costs and costs associated with collaborative R&D and in-licensing
arrangements. In addition, we acquire R&D services from other companies and fund research institutions under agreements which we can generally terminate at will. R&D costs, including upfront fees and milestones paid to collaborators, are
expensed as incurred, if the underlying assets are determined to have no alternative future use. The costs of the acquisition of technology are capitalized if they have alternative future uses in other R&D projects or otherwise.



Milestone payments to other parties are expensed when the liability is incurred, which
is when the milestones are deemed probable. Milestone payments are included in research and development expenses.



Fees paid to contract research organizations to conduct clinical trials are expensed as incurred.



Income Tax



The Company provides for income taxes in accordance with Statement of Financial Accounting Standards No. 109, Accounting for Income Taxes, (SFAS
109). SFAS 109 requires the use of the asset and liability method of accounting for deferred income taxes. Under this method, deferred tax assets and liabilities are determined based on differences between financial reporting and tax bases of
assets and liabilities and are measured using the enacted tax rates and laws that will be in effect when the differences are expected to reverse. Deferred tax assets are reduced by a valuation allowance to reflect the uncertainty associated with
their ultimate realization.



As of January 1, 2007, the Company
adopted FASB Interpretation No. 48,Accounting for Uncertainty in Income Taxes an interpretation of FASB Statement No. 109, (FIN 48). FIN 48 creates a single model to address accounting for uncertainty in tax positions
taken or expected to be taken in a tax return. Under FIN 48, the tax benefit from an uncertain tax position may be recognized only if it is more likely than not that the tax position will be sustained, based solely on its technical merits.



Foreign Currency



The functional currency of GPC Biotech AG is the Euro whereas the functional currency
of GPC Biotech Inc. is the U.S. dollar. All balance sheet items have been converted into Euros using the exchange rate at the balance sheet date and all items in the statement of operations have been converted into Euros at an average exchange rate
for the year. The effect of the translation is shown as a separate component of shareholders equity.



Gains and losses resulting from foreign currency transactions denominated in a currency other than the functional currency are recorded at the approximate rate of
exchange at the transaction date. For the years ended December 31, 2007 and 2005, the Company recorded net foreign currency gains of 221,000 and 2,416,000, respectively. For the year ended December 31, 2006, the Company recorded a net foreign currency loss of 2,141,000, which is recorded in other income (expense), net.



Stock-Based Compensation



Effective January 1, 2006, the Company adopted the fair value recognition provisions for stock-based awards granted to employees using the modified prospective
transition method provided



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by Statement of Financial Accounting Standards No.123(R), Share-Based Payment, (SFAS 123(R)). Compensation cost of equity awards are measured at
grant date, based on the fair value of the award, and is recognized as expense over the employee requisite service period which is the longer explicit service period stipulated in the contract or the derived service period. The derived service
period is inferred from valuation techniques used by the Company to estimate fair value. Awards are considered vested when the requisite service period has been rendered. Liability awards vest upon the achievement of certain performance conditions.
Compensation expense is recognized when these events are deemed probable. Compensation expense is recorded in research and development and general and administrative expense in the Consolidated Statement of Operations. See Footnote 15 for additional
information.



New Accounting Pronouncements



Accounting Pronouncements Adopted in 2007



As of January 1, 2007, the Company adopted FASB Interpretation No. 48,Accounting for Uncertainty in Income Taxes an interpretation of FASB Statement No. 109, (FIN 48). FIN 48 creates a single model to address accounting for uncertainty in tax positions taken or expected to be taken in a tax
return. Under FIN 48, the tax benefit from an uncertain tax position may be recognized only if it is more likely than not that the tax position will be sustained, based solely on its technical merits. The Company has certain deferred tax assets as a
result of several years of losses from operations and currently has a full valuation allowance for those deferred tax assets and has not recognized any benefits from tax positions in earnings. Accordingly, the adoption of the provisions of FIN 48
did not have a material impact on the Companys financial statements. In May 2007, the FASB issued Staff Position 48-1, Definition of Settlement in FASB Interpretation No. 48, (FIN 48-1). FIN 48-1 provides guidance on
how an enterprise should determine whether a tax position is effectively settled for the purpose of recognizing previously unrecognized tax benefits. The Company adopted FIN 48-1 retroactively to the adoption of FIN 48. The adoption of FIN 48-1 did
not have a material impact on the Companys financial statements.



New
Accounting Pronouncements Issued in 2007



On June 14, 2007,
the FASB ratified EITF 07-3, Accounting for Non-Refundable Advance Payments for Goods or Services to Be Used in Future Research and Development Activities, (EITF 07-3). EITF 07-3 requires that all non-refundable advance payments
for research and development activities that will be used in future periods be capitalized until used. In addition, the deferred research and development costs need to be assessed for recoverability. EITF 07-3 is applicable for fiscal years
beginning after December 15, 2007 and is to be applied prospectively without the option of early application. The Company does not expect this issue to have a material effect on its financial statements.



On December 4, 2007, the FASB issued Statement No. 141(R), Business
Combinations, (SFAS 141(R)). The objective of this statement is to improve the relevance, representational faithfulness, and comparability of the information that a reporting entity provides in its financial reports about a business
combination and its effects. SFAS 141 (R) requires the new acquiring entity to recognize all assets acquired and liabilities assumed in the transactions; establishes an acquisition-date fair value for said assets and liabilities; recognizes and
measures the goodwill acquired in the business combination or a gain from a bargain purchase and fully discloses to investors the financial effect the acquisition will have. This statement shall be effective for fiscal years, and interim periods
within those fiscal years, beginning on or after December 15, 2008 and applies prospectively to business combinations for which the acquisition date is on or after the beginning of the first annual



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reporting period beginning on or after December 15, 2008. Earlier adoption is prohibited. The Company does not expect this issue to have a material effect on its
financial statements.



On December 4, 2007, the FASB issued
Statement No.160, Noncontrolling Interest in Consolidated Financial Statements, an amendment of ARB No. 51, (SFAS 160). The objective of this statement is to improve the relevance, representational faithfulness, and comparability of
the information that a reporting entity provides in its consolidated financial statements. SFAS 160 requires all entities to report minority interests in subsidiaries as equity but separate from the parents equity in the consolidated financial
statements and the amount of consolidated net income attributable to the parent and to the noncontrolling interest be clearly identified and presented on the face of the consolidated statement of income. It also requires entities provide sufficient
disclosures that clearly identify and distinguish between the interests of the parent and the interests of the noncontrolling owners. This statement shall be effective for fiscal years, and interim periods within those fiscal years, beginning on or
after December 15, 2008. SFAS 160 requires retrospective adoption of the presentation and disclosure requirements for existing minority interests. All other requirements of SFAS 160 shall be applied prospectively. Early adoption is prohibited.
The Company does not expect this issue to have a material effect on its financial statements.



On December 12, 2007, the FASB ratified EITF 07-1, Accounting for Collaborative Arrangement, (EITF 07-1). EITF 07-1 requires participants in a collaborative arrangement to present the results of
activities for which they act as the principal on a gross basis and to report any payments received from (made to) other collaborators based on other applicable GAAP or, in the absence of other applicable GAAP, based on analogy to authoritative or a
reasonable, rational, and consistently applied accounting policy election. Significant disclosures of the collaborative agreements are also required. EITF 07-1 is effective for annual periods beginning after December 15, 2008 and to be applied
retrospectively for collaborative arrangements existing at December 15, 2008 as a change of accounting principle. The Company does not expect this issue to have a material effect on its financial statements.



In September 2006, the FASB issued Statement of Financial Accounting Standards
No. 157, Fair Value Measurements, (SFAS 157). SFAS 157 defines fair value, establishes a framework for measuring fair value in generally accepted accounting principles, and expands disclosures about fair value measurements.
This standard becomes effective on January 1, 2008, and early adoption is encouraged. Currently this statement only affects the Company to the extent its financial assets are carried at fair value. The adoption of SFAS 157 is not expected to
have a significant impact on the Companys financial position or results of operations.



In February 2007, the FASB issued Statement of Financial Accounting Standards No. 159, The Fair Value Option for Financial Assets and Financial Liabilities, (SFAS 159).SFAS 159 permits entities
to choose to measure many financial instruments and certain items at fair value that are not currently required to be measured at fair value. The effective date for SFAS 159 is January 1, 2008, and early adoption is permitted, provided early
adoption of SFAS 157 is employed. There will be no impact on the Companys financial position or results of operations as the result of the adoption of SFAS 159.



4. Product Candidate Development and Licensing Activities



2007



In June 2007, the Company entered into a license agreement with Yakult Honsha Co. Ltd. (Yakult) for satraplatin in Japan. Under the terms of the
agreement, Yakult gained exclusive



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commercialization rights to satraplatin for Japan and is taking the lead in developing the drug in that country. Under the agreement, Yakult was required to make
an upfront payment of ¥1.2 billion (7.4 million) to the Company as reimbursement for past satraplatin development expenses. Payment was received in July 2007,
net of a withholding tax payment to the Japanese government totalling 0.7 million. The tax payment was recorded in other expense in 2007.



This license agreement has been accounted for as one accounting unit, following the
guidance provided by EITF 00-21. The upfront payment of ¥1.2 billion (7.4 million) for the reimbursement of past satraplatin development expenses has been
deferred and will be recognized over the Companys period of substantial involvement which was initially not determinable. Due to the recent topline overall survival results of the SPARC Trial, announced in late October 2007, which showed that
satraplatin did not demonstrate an improvement in overall survival in the total patient population, the Company has not been able to estimate this period and will continue to defer the revenue until the impact of the overall survival results upon
the timing of the related product development plan can be reliably determined.



Also, according to the license agreement, Yakult is obligated to make additional payments to the Company based on the achievement of certain regulatory filing and approval milestones. These revenues, if any, will be recognized when the
milestone is achieved. In addition, the Company will receive a minimum of 21.1% royalties on net sales of satraplatin in Japan.



In March 2007, GPC Biotech entered into a development and supply agreement with a biologics supplier under which the biologics supplier agreed to: (1) develop
a high-productivity cell line and develop and scale-up a robust manufacturing process and (2) produce quantities of 1D09C3 bulk drug substance for clinical development and commercial supply. In February 2008, the Company announced that it had
decided to discontinue internal development of 1D09C3. Whereas the agreement remained in place as of December 31, 2007, no further payments were outstanding to the supplier as of that date. All prior payments related to this agreement were
charged to research and development expenses as services were rendered, all of which have been expensed as of December 31, 2007.



Prior to 2007



Effective December 19, 2005, the Company entered into a co-development and license agreement with Pharmion GmbH (Pharmion), a wholly owned subsidiary of
Pharmion Corporation, whereby Pharmion was granted exclusive commercialization rights in certain territories for satraplatin for the treatment of cancer in humans. Pharmions territories are Europe, Turkey, the Middle East, Australia and New
Zealand, while GPC Biotech retains rights to all other territories including North America, South America and parts of Asia, including Japan. Under the terms of the agreement, Pharmion made an upfront payment of $37.1 million to GPC Biotech,
including an $18 million reimbursement fee for costs previously incurred related to the development of satraplatin (a cost reimbursement) and $19.1 million to fund ongoing and certain future clinical development activities to be conducted jointly by
Pharmion and GPC Biotech. Under the terms of the agreement, the companies are to pursue a joint development plan for satraplatin in a variety of tumor types and to share global development costs for at least one additional registration trial, for
which Pharmion made an additional commitment of $22.2 million, in addition to the $37.1 million in initial payments received in January 2006. Pharmion will also pay GPC Biotech $30.5 million based on the achievement of certain regulatory filing and
approval milestones for the first indication, and up to an additional $75 million for up to five subsequent EMEA approvals for additional indications. GPC Biotech will also receive royalties on sales of satraplatin in Pharmions territories at
rates of 26.25 to 30 percent on annual sales up to $500 million, and 34 percent on annual sales over $500 million. Pharmion will pay GPC Biotech sales milestones totaling up to $105 million, based on the achievement of significant annual sales



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levels in the Pharmion territories. Pharmion and GPC Biotech will lead regulatory and commercial activities in their respective territories. The two companies also
signed a separate supply agreement.



Based on the guidance included in
EITF 00-21, the Company has used the residual method to assess the fair value of the multiple deliverable elements in this agreement. The $18 million upfront cost reimbursement is recognized as revenue ratably over the period of substantial
involvement of the Company in the development activities. The $19.1 million for shared development costs are treated as prepaid development costs and are recognized as shared development costs as incurred. Revenues resulting from the supply
agreement, royalties and milestone payments will be recognized when earned. Revenues, if any, from substantive milestones achieved under the agreement with Pharmion are recognized immediately when achieved.



In November 2007, Pharmion and Celgene Corporation announced the acquisition of
Pharmion by Celgene. That acquisition closed on March 7, 2008. GPC Biotech plans to discuss satraplatin development plans in more detail with Celgene now that this transaction has closed. GPC Biotech does not believe this acquisition
will have an impact on the co-development and license agreement for satraplatin between the Company and Pharmion.



On December 17, 2004, the Company licensed to Debiopharm S.A. (Debiopharm) the exclusive, worldwide rights to develop and commercialize the
Companys pre-clinical small molecule MHC class II antagonists program. On July 30, 2007, Debiopharm notified the Company that it was terminating this license agreement, which became effective in January 2008. Upon the effective
termination date, all rights, licenses and grants were returned to GPC Biotech.



On September 30, 2002, the Company signed an agreement with Spectrum Pharmaceuticals, Inc. (Spectrum), (formerly NeoTherapeutics, Inc.) granting GPC Biotech the exclusive worldwide license to satraplatin for the treatment
of cancer in humans. An initial licensing fee of $2 million was paid to Spectrum upon signing. In October 2003, another licensing fee was paid upon the dosing of the first patient in a registrational Phase 3 study in the amount of $2 million
(approximately 1.7 million), consisting of a $1 million cash payment and a $1 million equity investment. The equity investment in Spectrum represents 128,370
shares of Spectrum. Under the terms of the agreement, GPC Biotech will also pay milestones totaling up to $18 million. Subject to certain limitations, Spectrum is entitled to receive a share of sublicense fees received by GPC Biotech if the Company
enters into a licensing agreement with other companies. Under the terms of the agreement, GPC Biotech or its sublicensees will fully fund development and commercialization expenses for satraplatin.



During 2007, the U.S. FDA and the EMEA in Europe accepted the Companys filing of
the NDA and the MAA for satraplatin for patients with hormone-refractory prostate cancer (HRPC) whose prior chemotherapy has failed. In connection with these acceptances, the Company paid Spectrum approximately 2.9 million and 1.5 million, respectively. These payments were made in 2007 and charged to
research and development expense in 2006 when these events were deemed probable.



5.
Collaboration Agreements



The Company has entered into several
collaboration and license agreements with life science companies which are typically based on licensing technology platforms and funded research. These agreements include alliances based on the transfer and/or non-exclusive licenses of technology
platforms, alliances which combine a technology license with a focus on a specific disease or therapeutic approach, and disease-focused programs under which the Company conducts research funded by its partners. The Companys technology-based
alliances are generally structured as research collaborations. Under these arrangements, the Company performs research in a specific



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disease area aimed at discoveries leading to novel pharmaceutical products. These alliances generally provide research funding over an initial period, with renewal
provisions, varying by agreement. Under these agreements, the Companys partners may make up-front payments, license payments, ongoing research funding payments, and additional payments upon the achievement of specific research and product
development milestones and/or pay royalties or, in some cases, make profit-sharing payments to the Company based upon any product sales resulting from the collaboration.



Total revenue recognized under collaboration and license agreements amounted to 18,022,000, 22,252,000 and 9,341,000 for the years ended
December 31, 2007, 2006 and 2005, respectively. Total costs incurred under research collaborations and license agreements amounted to 6,712,000, 10,331,000 and 910,000 for the years ended December 31, 2007, 2006 and 2005,
respectively.



Effective January 31, 2003, the Company entered into
an agreement with ALTANA Pharma to license the Companys proprietary drug-protein interaction technology, LeadCode, to evaluate compounds in the public domain, as well as certain proprietary compounds of ALTANA Pharma. Under the terms of
this agreement, the Company received additional funding for the license, transfer and implementation of LeadCode for use at the ALTANA Research Institute. In addition, the Company was eligible to receive over $15 million in milestone payments,
in addition to royalties, for each product that was a direct result of the collaboration. This agreement expired June 30, 2007, and the Company did not receive any milestone payments.



Effective November 1, 2001, the Company entered into an alliance with ALTANA
Pharma to establish a U.S. Research Institute in Waltham, MA (USA) to use the Companys genomic and proteomic technologies. ALTANA Pharma and the Company entered into three agreements under which the Company receives funding under a
collaboration and license agreement in the form of an upfront payment, technology license and implementation fees, as well as research and technology transfer funding. Under this agreement, the Company non-exclusively licensed selected genomics,
proteomics, automation and bioinformatics technologies to ALTANA Pharma and was to collaborate with ALTANA Pharma on two drug discovery programs. The Company received further funding under a sublease agreement which expired on June 30, 2007. In
addition, the Company was eligible to receive implementation, research, preclinical and clinical milestone payments and royalty payments for each product resulting from the two collaborative drug discovery programs. The establishment term expired in
June 2007.



6. Marketable Securities and Short-Term Investments



The following is a summary of the balances of marketable securities and short-term
investments at December 31, 2007 and 2006 (in thousand ):



|                       |  |        |  |       
|---------------------- |  | ------ |  | ------
|                       |  | 2007   |  | 2006  
|Marketable securities  |  | 14,077 |  | 35,504
|Short-term investments |  | -      |  | 21,682
|                       |  |        |  |       
|Total                  |  | 14,077 |  | 57,186
|                       |  |        |  |       



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The following is a summary of marketable securities at December 31, 2007 and 2006 (in thousand ), all of which are available-for-sale:



|                              |  |        |  |                      |  |                       |   |  |                   
|----------------------------- |  | ------ |  | -------------------- |  | --------------------- | - |  | ------------------
|                              |  | 2007  
|                              |  | Cost   |  | GrossUnrealizedGains |  | GrossUnrealizedLosses |   |  | EstimatedFairValue
|Variable rate corporate bonds |  | 10,002 |  | -                    |  | (4                    | ) |  | 9,998             
|Fixed rate corporate bonds    |  | 3,847  |  | -                    |  | (13                   | ) |  | 3,834             
|Equity securities             |  | 390    |  | -                    |  | (145                  | ) |  | 245               
|                              |  |        |  |                      |  |                       |   |  |                   
|Total                         |  | 14,239 |  | -                    |  | (162                  | ) |  | 14,077            
|                              |  |        |  |                      |  |                       |   |  |                   
|                              | 
|                              |  | 2006  
|                              |  | Cost   |  | GrossUnrealizedGains |  | GrossUnrealizedLosses |   |  | EstimatedFairValue
|Variable rate corporate bonds |  | 20,978 |  | 24                   |  | (3                    | ) |  | 20,999            
|Fixed rate corporate bonds    |  | 14,054 |  | -                    |  | (87                   | ) |  | 13,967            
|Equity securities             |  | 390    |  | 148                  |  | -                     |   |  | 538               
|                              |  |        |  |                      |  |                       |   |  |                   
|Total                         |  | 35,422 |  | 172                  |  | (90                   | ) |  | 35,504            
|                              |  |        |  |                      |  |                       |   |  |                   



The fair market values of
marketable securities are based on quoted market prices. All bonds included in marketable securities have maturities of 3 years or less.



The marketable equity securities above represent 128,370 registered shares of Spectrum Pharmaceuticals, Inc. purchased in 2003 in accordance with a licensing
agreement (see Footnote 4).



In October of 2007 the Company sold all of
its short term investments and reinvested the proceeds in other interest bearing money market accounts.



The following is a summary of the short-term investments at December 31, 2006 (in thousand ), all of which were available-for-sale:



|          |  |        |  |                      |  |                   
|--------- |  | ------ |  | -------------------- |  | ------------------
|          |  | 2006  
|          |  | Cost   |  | GrossUnrealizedGains |  | EstimatedFairValue
|Bond Fund |  | 21,334 |  | 348                  |  | 21,682            
|          |  |        |  |                      |  |                   
|Total     |  | 21,334 |  | 348                  |  | 21,682            
|          |  |        |  |                      |  |                   



The gross unrealized losses and
accrued interest receivable were 0 in 2007 and 2006.



The realized gain on available-for-sale marketable securities and short-term investments in 2007, 2006 and 2005 was 381,000, 85,000 and 331,000,
respectively. The realized loss on available-for-sale marketable securities and short-term investments amounted to 0 in 2007, 2006 and 2005. Realized gains and
losses are calculated using specific identification to determine cost basis and are included in other income (expense), net.



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The aggregate unrealized losses on available-for-sale marketable securities and short-term investments at
December 31, 2007 were 17,000. The aggregate fair value of securities with unrealized losses at December 31, 2007 was 13,832,000 and consisted of the following (in thousand ):



|                              |  |                    |  |                |   |  |                    |  |                |  |        |  |                |  
|----------------------------- |  | ------------------ |  | -------------- | - |  | ------------------ |  | -------------- |  | ------ |  | -------------- | -
|                              |  | Less than12 Months |  |                |   |  | 12 Monthsor Longer |  |                |  | Total  |  |                |  
|                              |  | Cost               |  | UnrealizedLoss |   |  | Cost               |  | UnrealizedLoss |  | Cost   |  | UnrealizedLoss |  
|Variable rate corporate bonds |  | 10,002             |  | (4             | ) |  | -                  |  | -              |  | 10,002 |  | (4             | )
|Fixed rate corporate bonds    |  | 3,847              |  | (13            | ) |  | -                  |  | -              |  | 3,847  |  | (13            | )
|                              |  |                    |  |                |   |  |                    |  |                |  |        |  |                |  
|Total                         |  | 13,849             |  | (17            | ) |  | -                  |  | -              |  | 13,849 |  | (17            | )
|                              |  |                    |  |                |   |  |                    |  |                |  |        |  |                |  



Securities that are in loss
positions consist of debt securities only, which are corporate bonds from highly rated issuers. All unrealized losses are considered to be temporary in nature. Management believes that the impairments extend from increases in the current market
interest rates compared with the market rate at which time the bonds were purchased. Management further believes that the impairments do not extend from decreases in the quality ratings of the issuing companies. The bonds all have maturities of less
than three years. The Company has the ability and positive intent to hold these bonds until there has been a full recovery of their carrying values. The Company also believes that it will be able to collect both principal and interest amounts due to
the Company at maturity, given the high credit quality of these investments. Management has no intention to sell the financial instruments until maturity, at which point the Company expects the full value of the bonds to be recovered. Subsequent to
year-end, and upon the maturity of these investments, all of the Companys variable rate securities were sold at cost.



The aggregate unrealized losses on available-for-sale marketable securities and short-term investments at December 31, 2006 were 90,000. The aggregate fair value of securities with unrealized losses at December 31, 2006 was 23,965,000 and consisted of equity securities and fixed-rate corporate bonds with remaining maturities of less than three years. These securities were in a loss position for less than 12 months as of December 31, 2006.



During the year ended December 31, 2006, a loss was recognized in
the statement of operations for available-for-sale marketable equity securities which were deemed to be other-than-temporarily impaired based on the significance of the decline in fair value and the length of the impairment. Accordingly, a loss in
the amount of 390,000 was reclassified out of accumulated other comprehensive loss into other income (expense), net, on the statement of operations in 2006.
However, at year end 2006, the fair value of these equity instruments increased slightly, whereby the Company recorded unrealized gains in the amount of 148,000
which were included in other comprehensive income. No such charges were recorded in the statement of operations in 2007.



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7. Property and Equipment



Property and equipment consisted of the following at December 31, 2007 and 2006 (in thousand ):



|                                             |  |        |   |  |        |  
|-------------------------------------------- |  | ------ | - |  | ------ | -
|                                             |  | 2007   |   |  | 2006   |  
|Leasehold improvements                       |  | 1,538  |   |  | 1,912  |  
|Office and laboratory equipment              |  | 3,647  |   |  | 6,067  |  
|Computer equipment and related software      |  | 3,628  |   |  | 3,862  |  
|Furniture and fixtures                       |  | 1,071  |   |  | 876    |  
|                                             |  |        |   |  |        |  
|                                             |  | 9,884  |   |  | 12,717 |  
|Less accumulated depreciation and impairment |  | (6,814 | ) |  | (8,458 | )
|                                             |  |        |   |  |        |  
|Property and equipment, net                  |  | 3,070  |   |  | 4,259  |  
|                                             |  |        |   |  |        |  



Depreciation expense amounted to
1,607,000, 1,532,000, and 3,478,000 in 2007, 2006 and 2005, respectively, and is included in research and development expenses and general and administrative expenses. Refer to Footnote 10 for description of impairment
charge recognized in 2007. The Company did not record any impairment for the years ended December 31, 2006 and 2005.



8. Intangible Assets



The Company has recorded intangible assets acquired in a business combination and an asset acquisition based on their fair values, as determined by independent
valuations at the date of acquisition. Additionally, intangible assets have been recorded as a result of license purchases. The table below summarizes intangible assets, all of which are amortized, as of December 31 (in thousand ):



|                               |  |        |   |  |        |  
|------------------------------ |  | ------ | - |  | ------ | -
|                               |  | 2007   |   |  | 2006   |  
|Gross carrying amount          |  |        |   |  |        |  
|Patents and licenses           |  | 455    |   |  | 508    |  
|Other intangible assets        |  | 956    |   |  | 956    |  
|                               |  |        |   |  |        |  
|Total gross carrying amount    |  | 1,411  |   |  | 1,464  |  
|                               |  |        |   |  |        |  
|Accumulated amortization       |  |        |   |  |        |  
|Patents and licenses           |  | (291   | ) |  | (244   | )
|Other intangible assets        |  | (956   | ) |  | (815   | )
|                               |  |        |   |  |        |  
|Total accumulated amortization |  | (1,247 | ) |  | (1,059 | )
|                               |  |        |   |  |        |  
|Total intangible assets, net   |  | 164    |   |  | 405    |  
|                               |  |        |   |  |        |  



GPC Biotech reviews intangible
assets for impairment on an annual basis. The Company did not record any impairment for the years ended December 31, 2007, 2006 and 2005.



The amortization expense for intangible assets for the years ended December 31, 2007, 2006 and 2005 was 218,000, 325,000, and 417,000, respectively.



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The estimated amortization expense for intangibles for the next five years is as follows (in thousand ):



|                                |  |   
|------------------------------- |  | --
|For the year ended December 31, |  |   
|2008                            |  | 73
|2009                            |  | 73
|2010                            |  | 18
|Thereafter                      |  | 0 



9. Accrued Expenses and Other Current
Liabilities



The following is a summary of the balances of accrued
expenses at December 31, 2007 and 2006 (in thousand ):



|                                                   |  |        |  |       
|-------------------------------------------------- |  | ------ |  | ------
|                                                   |  | 2007   |  | 2006  
|Accrued restructuring                              |  | 4,541  |  | -     
|Accrued milestone payments                         |  | -      |  | 4,544 
|Accrued external research and development          |  | 2,340  |  | 2,779 
|Accrued personnel expenses and payroll liabilities |  | 1,899  |  | 3,042 
|Accrued legal and advisory                         |  | 295    |  | 741   
|Accrued outstanding invoices                       |  | 401    |  | 1,836 
|Accrued lease obligations                          |  | 38     |  | 330   
|Current portion of convertible bonds               |  | 174    |  | -     
|Amounts due on cancelled bonds                     |  | 268    |  | -     
|Current portion of loss on sublease contract       |  | -      |  | 578   
|Liability from stock appreciation rights           |  | 33     |  | 169   
|Other accruals and current liabilities             |  | 456    |  | 327   
|                                                   |  |        |  |       
|Total                                              |  | 10,445 |  | 14,346
|                                                   |  |        |  |       



During the year ended
December 31, 2006, the Company accrued two milestone obligations to a third party whereby an amount of $6 million (approximately 4.5 million) was charged to
research and development expenses. These contractual obligations became due and were paid in 2007 in connection with the acceptance of the filings of the NDA with the FDA and the MAA with the EMEA.



10. Restructuring Activities



During 2007 the Company had several restructuring activities and recorded the costs associated with these activities in accordance
with SFAS No. 146, Accounting for Costs Associated with Exit or Disposal Activities, (SFAS 146):



On May 3, 2007, the Company announced the consolidation of its drug discovery efforts to one location, resulting in the closing of the facility in Waltham,
Massachusetts, USA and a total workforce reduction of approximately 16%. The Company incurred a total restructuring charge of 1.0 million in 2007, primarily
relating to employee severance and termination costs. These charges are included in both research and development and general and administrative expenses. This restructuring was completed by the end of 2007.



In addition, the Company has incurred, and will continue to incur through 2008, certain
contract termination costs relating to the closing of the Waltham facility. Prior to the announcement of the reorganization, the Company had a remaining sublease loss liability relating to the same facility totaling



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4.0 million, which was charged to expense in prior years in accordance with
SFAS 146 (see Footnote 11 for details). Because this liability was deemed adequate to cover all contract termination costs and professional fees associated with this restructuring, no additional amounts have been charged to expense in the current
year. However, during the third quarter of 2007, the Company adjusted this liability down as the Companys facility closing costs were lower than originally anticipated. This reduction was recorded to general and administrative expense.



On August 23, 2007, the Company announced a restructuring plan that
involved a U.S. staff reduction of approximately 15% of the Companys total workforce. The Company recognized a total restructuring charge of 0.7 million in 2007, primarily relating to employee severance and termination costs. The charges are included in both research and development and general and administrative expenses. This restructuring was completed by the end
of 2007.



On November 15, 2007, the Company announced an additional
restructuring plan that involved staff reductions of approximately 44% of the total workforce and included both GPC Biotech AG and its subsidiary. The Company recognized a total restructuring charge of 2.5 million in 2007, primarily relating to employee severance and termination costs in both Germany and the U.S. These charges are included in both research and development and general and
administrative expenses. The Company expects this restructuring to be completed in the first quarter of 2008.



A summary of the significant components of the restructuring liability is as follows (in thousand ):



|                                                  |  |                             |   |  |                                                  |   |  |        |  
|------------------------------------------------- |  | --------------------------- | - |  | ------------------------------------------------ | - |  | ------ | -
|                                                  |  | EmployeeTerminationBenefits |   |  | Sublease LossAccrual andContractTerminationCosts |   |  | Total  |  
|January 1, 2007 Balance                           |  | -                           |   |  | 3,967                                            |   |  | 3,967  |  
|                                                  |  |                             |   |  |                                                  |   |  |        |  
|Amortization of Sublease Loss including Interest  |  | -                           |   |  | (1,051                                           | ) |  | (1,051 | )
|Restructuring Charges                             |  | 4,058                       |   |  | 110                                              |   |  | 4,168  |  
|Restructuring Payments                            |  | (1,509                      | ) |  | (116                                             | ) |  | (1,625 | )
|Reversal/change in estimate sublease loss accrual |  | -                           |   |  | (2,916                                           | ) |  | (2,916 | )
|Contract termination costs                        |  | -                           |   |  | 2,395                                            |   |  | 2,395  |  
|Exchange Differences                              |  | (222                        | ) |  | (175                                             | ) |  | (397   | )
|                                                  |  |                             |   |  |                                                  |   |  |        |  
|December 31, 2007 Balance                         |  | 2,327                       |   |  | 2,214                                            |   |  | 4,541  |  
|                                                  |  |                             |   |  |                                                  |   |  |        |  



In 2007, the Company recorded
impairment charges of approximately 0.9 million, which represented the difference between the fair value of the assets no longer used and available for sale,
and their net carrying value. These fixed assets are no longer in use as a result of the restructuring at the Waltham, Princeton and Munich facilities. These charges primarily related to laboratory equipment, computers and office furniture and were
recorded in general and administrative expense in accordance with Statement of Financial Accounting Standards No. 144, Accounting for the Impairment or Disposal of Long-Lived Assets, (SFAS 144).See Impairment of
Long-Lived Assets in Footnote 3.



In addition, the Company recorded a
loss on lease of approximately 0.1 million in 2007 relating to vacated space at the Munich facility.



Refer to Footnote 20 regarding details of an additional restructuring announced after
December 31, 2007.



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11. Accrued Loss on Sublease Contract, Non-Current



In the second quarter of 2006 the Company decided not to reoccupy certain office and laboratory space at its Waltham facility in
Massachusetts, USA, at the end of a sublease term as it had initially planned. In accordance with Financial Accounting Standards Board Technical Bulletin 79-15, Accounting for Loss on Sublease Not Involving the Disposal of a Segment, and
Statement of Financial Accounting Standards No. 146, Accounting for Costs Associated with Exit of Disposal Activities, the Company recorded a provision for this space for the period from the expiration of the current sublease through the
end of the Companys original lease term. The provision was calculated based on the current estimate of the fair value of potential sublease income during that period.



The total sublease loss incurred in 2006 relating to this space amounted to 1,980,000. The amount represents the discounted future estimated net cash disbursements over the remaining period of the lease agreement.



On May 1, 2005, the Company sublet to a third party excess office and laboratory space in the U.S. According to FASB Technical
Bulletin 79-15 and SFAS 146, the Company recorded an expense and a liability related to the projected shortfall between the rent obligation under the lease and the rental income to be received over the term of the sub-lease. The expense recorded at
sublease inception amounted to 2,849,000.



The total balance of the liability as of December 31, 2006 was 3,967,000
of which 3,389,000 was included in other liabilities, non-current and 578,000
was included in other current liabilities. During 2007, the Company agreed on a termination of this lease and recorded a contract termination fee (see Footnote 10). Amounts accrued as contract termination costs are included in current liabilities.



12. Commitments and Contingencies



Operating Lease Commitments



The Company has entered into several lease arrangements for office, laboratory and storage space as well as for laboratory and office
equipment. In total, the Company incurred lease expenses of 4,756,000, 4,804,000 and 7,306,000 in the years 2007, 2006 and 2005, respectively. Income from subleases of office and laboratory space amounted to 801,000, 1,353,000, and 1,311,000 in the years 2007, 2006 and 2005, respectively. Lease expenses and sublease income are included in research and development and general and administrative expenses.



The Company has entered into several lease agreements for office and laboratory space
as well as for office and laboratory equipment that expire at different times through 2015. However certain leases can be terminated earlier at the option of the Company. One agreement calls for future incremental increases in rental payments in
2008 and 2010. The escalation costs are expensed over the life of the lease. The balance of accrued rental payments at December 31, 2007 was 38,000.



The lease for the Waltham facility was terminated in 2007. As a result
of the termination, the Company is required to pay a lease termination fee of approximately 2.1 million. The Company will pay this amount over the first nine
months of 2008. This contract termination cost was accrued as of December 31, 2007 (see Footnote 10). The terminated facility lease also requires a deposit of $1.7 million (approximately 1.2 million) to be held in escrow as security for credit until the termination costs have been paid. This amount has been classified as short-term restricted cash as of December 31, 2007. The Company records its
rental expense and sublease rental income using the straight-line method in accordance with Statement of Financial Accounting Standards No. 13, Accounting for Leases, (SFAS 13).



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In certain leases the Company provided a customary indemnification to the lessor for certain claims that may arise
under the lease. These indemnification obligations are not capped at a specific amount. Accordingly, the maximum amount of potential future payments that might arise under these indemnification obligations cannot be reasonably estimated. However,
the Company has not experienced any claims under similar lease indemnification provisions in the past and management has determined that the associated estimated fair value of the liability is not material. Thus, the Company has not recorded any
liability for these indemnities in the consolidated financial statements. The Company does, however, accrue for losses for any known contingent liability, including those that may arise from indemnification provisions, when a future payment is both
reasonably estimable and probable. The Company carries specific and general liability insurance policies which the Company believes would provide, in most cases, some, if not total, recourse in the event of any claims arising under these lease
indemnification provisions.



Future minimum lease commitments for all
non-cancelable operating leases for the years ending December 31 are as follows (in thousand ):



|                                |  |      
|------------------------------- |  | -----
|Non-cancelable operating leases |  |      
|2008                            |  | 1,092
|2009                            |  | 622  
|2010                            |  | 9    
|2011                            |  | 2    
|Thereafter                      |  | -    



Contingencies



From time to time, the Company may be party to certain legal proceedings and claims
which arise during the ordinary course of business. Legal proceedings are subject to various uncertainties and the outcomes are difficult to predict. GPC Biotech may incur significant expense in defending these or future lawsuits. However, in the
opinion of management, the ultimate outcome of these matters will not have material adverse effects on the Companys financial position, results of operations or cash flows. In accordance with Statement of Financial Accounting Standards
No. 5, Accounting for Contingencies, (SFAS 5), the Company makes a provision for a liability when it is both probable that a liability has been incurred and when the amount of the loss is reasonably estimable.



GPC Biotech has entered into agreements under which it may be obligated to make
payments (milestone/sub-license payments) that are contingent upon the occurrence of certain events (milestones). As of December 31, 2007, the total maximum amount of milestone payments the Company may be obligated to
make under these agreements was approximately 40.2 million. However, this amount included obligations related to pre-clinical and earlier stage projects, as well
as projects that may be discontinued and, therefore, it is unlikely that all of these milestones will be achieved. In 2007 and 2006, the Company made actual milestone payments of 5.2 million and 0, respectively, under these arrangements.



The actual amounts and timing of these contingent payments depend on numerous factors some of which are outside of the Companys
control, including the success of our preclinical and clinical development efforts with respect to the products being developed under these agreements, the determination of the FDA and other regulatory authorities, the determination of the United
States Patent and Trademark Office, the volume of sales or gross margin of a product in a specified territory and other factors. Accordingly, costs related to these payments are only reflected in the consolidated financial statements when the
achievement of the underlying milestone is incurred, or when the related milestone is deemed probable.



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Arbitration Proceedings



On December 12, 2006, the Company was notified by Spectrum Pharmaceuticals Inc. (Spectrum), that Spectrum had initiated an arbitration proceeding
with the American Arbitration Association in the United States to resolve a dispute between the companies under the co-development and license agreement for satraplatin. In the course of the arbitration proceedings, Spectrum made several claims of
breach of contract, including (1) an assertion that it was entitled to a payment from GPC Biotech of approximately 9.0 million relating to payments
received by GPC Biotech under the co-development and license agreement between GPC Biotech and Pharmion GmbH entered on December 19, 2005, (2) a claim that GPC Biotech had not used commercially reasonable efforts to obtain regulatory
approval and to promote the distribution of satraplatin in Japan, and (3) a claim that GPC Biotech had not negotiated with Spectrum in good faith regarding the co-promotion of satraplatin in the United States. Spectrum also sought a declaration
that GPC Biotechs alleged breaches of contract provided a basis for termination of the co-development and license agreement. The hearing was completed on July 13, 2007. On November 5, 2007, the Company announced that a
three-arbitrator panel of the American Arbitration Association issued its decision in favor of GPC Biotech. The panel unanimously rejected all of Spectrums claims and found no violations of the agreement by GPC Biotech. The decision of
the panel included the following key rulings:



| |  | Spectrum is not entitled to any portion of the up-front payments that GPC Biotech received from Pharmion or from Yakult;
| | - | ------------------------------------------------------------------------------------------------------------------------



| |  | Spectrum does not have a contractual right to co-promote satraplatin in the United States and GPC Biotech did not violate any obligation to negotiate in good faith a co-promotion agreement;
and
| | - | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  | GPC Biotech did not violate its obligation to use commercially reasonable efforts to commercialize satraplatin in Japan.
| | - | ------------------------------------------------------------------------------------------------------------------------



Although the panel ruled for GPC Biotech on the merits, it did not award GPC Biotech
reimbursement of attorneys fees and costs.



Fees which the Company
paid to its external legal advisors and for other services associated with this arbitration process were expensed in the period when such legal and other services were rendered.



Shareholder Litigation



In July 2007, the Company and certain of its current and former officers were sued in the United States District Court for the Southern District of New York in
three separate securities fraud class action lawsuits on behalf of all persons who purchased the securities of GPC Biotech between December 5, 2005 and July 24, 2007, inclusive. The suits have since been consolidated and a lead
plaintiff has been appointed. The lead plaintiff's consolidated complaint was filed on March 12, 2008. The consolidated complaint alleges that GPC Biotech violated U.S. federal securities laws by making misleading public statements
relating to the prospects of its most advanced product candidate, satraplatin, and thereby artificially inflating the price of GPC Biotech securities. The consolidated complaint also names Bernd R. Seizinger (CEO) and three former members of
the Company's Management Board, Mirko Scherer, Elmar Maier, and Sebastian Meier-Ewert, as defendants. The Company's response to the consolidated complaint is due on May 14, 2008.



The plaintiffs seek monetary damages in an unspecified amount. GPC Biotech believes the
allegations to be without merit and intends to vigorously defend the Company. GPC Biotech cannot predict the outcome of the suit and is not currently able to estimate the possible cost to the Company from this suit, given the early stage of the
proceedings.



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##### Table of Contents

Stock Appreciation Rights



In 2004, the Company began issuing stock appreciation rights (SARs) to senior management and members of the Supervisory Board. These SARs are vested on
the achievement of certain performance conditions as described in Footnote 15.



Due to the uncertainties in the approval process of satraplatin in second-line HRPC, there were no liabilities and expenses recognized as of December 31, 2007 with respect to such contingent payments triggered by the approval of
satraplatin. The intrinsic value at December 31, 2007 of such stock appreciation rights was 0.



Contingencies related to the approval of the MAA for satraplatin in second-line HRPC by the EMEA



The Company has additional contingent commitments related to payments pending on the
marketing approval of satraplatin by the EMEA. As of December 31, 2007 the Company has assessed the probability of these contingent liabilities relating to the approval of satraplatin in second-line HRPC in Europe as less than probable for
accounting purposes.



Under the Companys agreement with Spectrum,
GPC Biotech is obligated to make a milestone payment in the amount of $3.0 million or approximately 2.0 million to Spectrum, which is contingent upon the
approval of the MAA by the EMEA.



In addition, the Company has a cash
bonus plan to retain the Companys employees and if EMEA approval is obtained, the total payout under this plan may lead to an increase in personnel expense of up to 239,000.



Contingent Gains



The Company is entitled to receive a milestone payment from Pharmion (net of licensing
fee paid to Spectrum) of approximately 11.3 million upon the approval of the MAA for satraplatin with the EMEA. Gross receipt will be recognized as revenue
upon milestone achievement.



Guarantees and Indemnification Obligations



The Company enters into agreements in the ordinary course of business
with, among others, vendors, service providers, contract manufacturers and collaboration, licensing and co-development partners. Pursuant to certain of these agreements it was agreed to indemnify the other party for certain matters, such as property
damage, personal injury, acts or omissions of the Company, or its employees, agents or representatives, or third party claims alleging that the activities of GPC Biotechs contractual partner pursuant to the contract infringe a patent,
trademark or copyright of such third party.



The Company has determined
the fair value of its liability on the above indemnities to be immaterial based on historical experience and information known at December 31, 2007.



13. Loans Receivable from Employees



At December 31, 2007 and 2006, loans receivable from employees of the Company amounted to 0 and 38,000, respectively, and are included in other current assets. The balance from 2006 was forgiven in 2007.



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Forgiveness of loans, if applicable, is included in compensation expense in the period the loans are forgiven and
is contingent upon continued employment of the employee. Loans made to employees bear interest at the rate of 5.5% to 6.0% per annum and were made for personal financial purposes.



14. Related Party Disclosures



In 2003 and 2001, the Company entered into collaboration agreements with ALTANA Pharma AG (ALTANA Pharma) as described in Footnote 5. ALTANA Pharma was
a related party, since the Companys Chief Executive Officer (Vorstandsvorsitzender), Dr. Bernd Seizinger, was a member of the Supervisory Board of ALTANA Pharma. The board membership of Dr. Seizinger ended
December 31, 2006.



At December 31, 2006, the Company had
accounts receivable from ALTANA Pharma arising out of the normal course of business in the amount of 395,000. All payments for accounts receivable from ALTANA
Pharma were settled for cash at amounts stipulated in the various contracts with ALTANA Pharma. Collaborative revenues and deferred revenues related to ALTANA Pharma have been classified as related party on the statements of operations and balance
sheets, respectively.



In addition, the Company had subleased part of its
facilities to ALTANA Pharma. Of the total sublease income disclosed in Footnote 12, 991,000 and 1,000,000 for the years ended December 31, 2006 and 2005, respectively, relates to the sublease with ALTANA Pharma. This sublease ended during 2007.



During 2006, the Company made a milestone payment totaling 436,000 to MorphoSys AG (MorphoSys), a related party to the Company. This payment was made under a collaboration and licensing agreement signed in April 1999. MorphoSys is a related party to the Company due to the fact
that two members of the Supervisory Board of the Company are also members of the Supervisory Board of MorphoSys. There were no payments to MorphoSys in 2007 or 2005.



15. Share Based Compensation



Effective January 1, 2006, the Company adopted SFAS 123(R) using the modified-prospective-transition method. Under that transition method, compensation cost
recognized includes: (a) compensation costs for all share-based payments granted prior to, but not yet vested as of January 1, 2006, based on the grant date fair value estimated in accordance with the original provisions of SFAS 123, and
(b) compensation cost for all share-based payments granted subsequent to January 1, 2006, based on the grant-date fair value estimated in accordance with the provisions of SFAS 123(R). Results for prior periods have not been restated.



Prior to the adoption of SFAS 123(R), the Company recorded all
forfeitures of share-based compensation in the statements of operations as they occurred. Upon adoption of SFAS 123(R), the Company estimated the forfeitures of unvested share-based compensation at January 1, 2006, and recorded a cumulative
effect of change in accounting principle in the statement of operations in the amount of 433,000.



Stock Options



The Company grants options to the employees and the members of the Management Board.



The respective strike prices for these stock options equal the five-day average of the closing price of the Companys ordinary shares prior to
the respective date of grants. The explicit service



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period is four years, with graded vesting of the options over the explicit service period. According to German law (§ 193 II, No. 3 AktG), the rights can be
exercised, at the earliest, two years after the grant. The maximum contractual term of stock options is ten years.



In addition to the aforementioned two-year waiting period, eligibility to exercise option rights is also subject to various stock performance hurdles (mostly, the
performance of GPC Biotechs stock relative to various indices as specified in each option plan) as required by German law. Accordingly, throughout these notes, exercisable refers to options that have satisfied both the explicit
service period and the two-year waiting requirements but still have to meet certain market conditions, whenever the options are exercised, within a specified period prior to the date of exercise.



The following is a summary of stock options activity for the year ended
December 31, 2007:



|                                    |  |           |   |  |                               |      
|----------------------------------- |  | --------- | - |  | ----------------------------- | -----
|                                    |  | 2007     
|                                    |  | Options   |   |  | Weighted-AverageExercisePrice
|Outstanding at January 1            |  | 3,847,345 |   |  |                              | 10.80
|Granted                             |  | 488,100   |   |  |                              | 16.58
|Exercised                           |  | (886,528  | ) |  |                              | 6.09 
|Forfeited                           |  | (467,375  | ) |  |                              | 16.72
|Expired                             |  | (124,854  | ) |  |                              | 12.97
|                                    |  |           |   |  |                               |      
|Outstanding at December 31          |  | 2,856,688 |   |  |                              | 12.18
|                                    |  |           |   |  |                               |      
|Vested & outstanding at December 31 |  | 2,237,189 |   |  |                              | 12.32
|                                    |  |           |   |  |                               |      
|Exercisable at December 31          |  | 2,164,814 |   |  |                              | 12.27
|                                    |  |           |   |  |                               |      



The total number of stock
options granted during the years 2007, 2006 and 2005 was 488,100, 317,500, and 308,301, respectively, and the related weighted-average grant date fair value was 8.97, 8.22, and 5.77, respectively.



The total number of stock options forfeited during the years 2007, 2006, and 2005 was
467,375, 61,330, and 50,864, respectively, and the related weighted-average fair value was 9.49, 5.99, and 7.40, respectively.



The total number and weighted-average grant date fair value of nonvested options at January 1, 2007 was 958,231 and 6.77, respectively, and at December 31, 2007 was 619,499 and 6.79, respectively.



The total number of options vested during the year ended December 31, 2007, 2006,
and 2005 was 352,857, 478,284, and 603,126, respectively, and the related weighted-average grant date fair value was 6.19, 4.80, and 5.31, respectively.



The total intrinsic value of stock options exercised during the years 2007, 2006 and 2005 respectively, was 10,595,000, 7,359,000 and 435,000 respectively.



Cash received from
the exercise of stock options as of December 31, 2007, 2006, and 2005 was 5,397,000, 3,866,000 and 486,000, respectively.



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As provided for by SFAS 123(R), the Company recognizes compensation cost on a straight-line basis over the
requisite service period determined for each tranche of the award as if the award was, in-substance, multiple awards. Derived service period approximates 5-7 years and represents an estimate of the period when market condition is expected to be
satisfied. The fair value of each option grant is estimated at grant date GPC Biotech used a Monte Carlo simulation to estimate fair values for all options granted since January 1, 2006.



The following weighted-average assumptions were used to value stock option grants:



|                         |  |               |  |               |  |       |  
|------------------------ |  | ------------- |  | ------------- |  | ----- | -
|                         |  | December 31,  | 
|                         |  | 2007          |  | 2006          |  | 2005  |  
|Expected dividend yield  |  | -             |  | -             |  | -     |  
|Risk-free interest rate  |  | 3.91%-4.47%   |  | 3.36%-4.01%   |  | 2.90  | %
|Expected volatility      |  | 54.56%-59.55% |  | 59.66%-70.44% |  | 77.81 | %
|Expected life (in years) |  | -             |  | -             |  | 4     |  



For 2007 and 2006, the Company
assumes early exercise behavior and estimates exercises after 100% performance increase of the stock.



The Company estimated expected volatility based on the historical realized volatility of the Companys stock and the historical correlation between the
Companys stock and the stock index over the past 5 years calculated individually at the date of grant. The Company uses historical data to estimate post vesting employment termination behavior within the valuation model. The risk-free rate for
periods within the contractual life of the option is based on the German government bond yield curve in effect at the time of grant.



For stock options issued during 2007, 2006 and 2005, total compensation cost was 4,376,000, 2,609,000 and 1,778,000, respectively, which is being
recognized over the requisite service period of those options. Compensation cost related to stock options included in the statements of operations was 589,000,
2,476,000 and 2,974,000 in 2007, 2006 and 2005, respectively. The decrease in
compensation cost for 2007 was mainly due to the increase in actual forfeitures. Upon forfeiture, compensation expense for awards which the requisite service period has not been rendered, is reversed.



As of December 31, 2007, there was 2,866,000 of total unrecognized compensation cost related to unvested share-based compensation arrangements granted under the plans. The weighted average period over which these compensation cost will be
recognized is approximately 57 months.



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##### Table of Contents

The following table represents weighted-average price and contractual life information regarding significant fully
vested stock options and stock options expected to vest at December 31, 2007:



|                                 |  |                                    |  |                                 |       |                                                      |     |        |           |                                 |   |                                                      |  |    
|-------------------------------- |  | ---------------------------------- |  | ------------------------------- | ----- | ---------------------------------------------------- | --- | ------ | --------- | ------------------------------- | - | ---------------------------------------------------- |  | ---
|                                 |  | Options Outstanding andExercisable |  | Options Outstanding and Vested 
|Range of Exercise Prices in Euro |  | Number                             |  | Weighted- Average ExercisePrice |       | Weighted- Average Remaining Contractual Life (Years) |     | Number |           | Weighted- Average ExercisePrice |   | Weighted- Average Remaining Contractual Life (Years)
|1.16 -   2.98                    |  | 18,910                             |  |                                | 2.50  |                                                      | 8.8 |        | 18,910    |                                 |  | 2.50                                                 |  | 8.8
|3.21 -   5.77                    |  | 179,743                            |  |                                | 4.10  |                                                      | 5.4 |        | 179,743   |                                 |  | 4.10                                                 |  | 5.4
|6.53 -   8.64                    |  | 246,267                            |  |                                | 6.75  |                                                      | 3.7 |        | 246,267   |                                 |  | 6.75                                                 |  | 3.7
|9.00 - 11.91                     |  | 848,644                            |  |                                | 9.73  |                                                      | 3.0 |        | 853,494   |                                 |  | 9.74                                                 |  | 3.0
|12.11 - 19.30                    |  | 817,275                            |  |                                | 17.18 |                                                      | 1.2 |        | 884,800   |                                 |  | 16.94                                                |  | 1.2
|19.67 - 59.74                    |  | 53,975                             |  |                                | 33.78 |                                                      | 0.5 |        | 53,975    |                                 |  | 33.78                                                |  | 0.5
|                                 |  |                                    |  |                                 |       |                                                      |     |        |           |                                 |   |                                                      |  |    
|                                 |  | 2,164,814                          |  |                                | 12.27 |                                                      | 2.6 |        | 2,237,189 |                                 |  | 12.32                                                |  | 2.5
|                                 |  |                                    |  |                                 |       |                                                      |     |        |           |                                 |   |                                                      |  |    



The aggregate intrinsic value
for fully vested stock options as of December 31, 2007, 2006, and 2005 was 4,000, 24,875,000 and 9,651,000, respectively. The aggregate intrinsic value for fully vested stock options exercisable as of December 31, 2007,
2006, and 2005 was 4,000, 24,230,000 and 9,415,000, respectively. The total fair value of shares vested during the year ended December 31, 2007, 2006, and 2005 was 2,216,000, 2,297,000 and 3,202,000,
respectively.



Upon the exercise of stock options, the Company issues new
shares by way of a capital increase.



Convertible Bonds



Convertible bonds are issued as compensation to members of the Management Board and
senior management and also in the past were issued to members of the Supervisory Board. Convertible bonds granted under the Companys convertible bonds plan have a four-year explicit service period with graded vesting schedule beginning on the
grant date and mature ten years after the date of grant. Eligibility to convert the bonds is subject to an initial two-year holding period and to various stock performance hurdles (the performance of GPC Biotechs stock relative to various
indices as specified in each convertible bond plan), each in accordance with German law. Holders are required to purchase the convertible bonds at a price of 1.00 per bond.



Each convertible bond entitles its
holder to convert such bond into one ordinary share of the Company at a fixed conversion price per share. The bonds will pay interest of 3.5% per annum. The convertible bonds do not specifically state a liquidation preference and therefore on
their face are pari-passu with the Companys general debt obligations, if any.



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The following is a summary of convertible bond activity for the year ended December 31, 2007:



|                                    |  |           |   |  |                                |      
|----------------------------------- |  | --------- | - |  | ------------------------------ | -----
|                                    |  | 2007     
|                                    |  | Shares    |   |  | Weighted-Average ExercisePrice
|Outstanding at January 1            |  | 3,369,139 |   |  |                               | 11.52
|Granted                             |  | 744,000   |   |  |                               | 21.30
|Exercised                           |  | (436,794  | ) |  |                               | 5.27 
|Forfeited                           |  | (298,500  | ) |  |                               | 15.93
|Expired                             |  | (12,500   | ) |  |                               | 10.90
|                                    |  |           |   |  |                                |      
|Outstanding at December 31          |  | 3,365,345 |   |  |                               | 14.10
|                                    |  |           |   |  |                                |      
|Thereof paid in                     |  | -         |   |  |                                | -    
|                                    |  |           |   |  |                                |      
|Vested & Outstanding at December 31 |  | 1,497,595 |   |  |                               | 10.81
|                                    |  |           |   |  |                                |      
|Exercisable at December 31          |  | 1,228,345 |   |  |                               | 9.50 
|                                    |  |           |   |  |                                |      



The total number of convertible
bonds granted during the years 2007, 2006 and 2005 was 744,000, 1,091,500, and 720,000, respectively, and the related weighted-average grant date fair value was 12.37, 9.57, and 6.13, respectively.



The total number of convertible bonds forfeited during the years 2007 and 2005 was
298,500 and 7,500, respectively, and the related weighted-average grant date fair value was 9.28 and 2.96, respectively. No convertible bonds were forfeited in 2006.



The total number and weighted-average grant date fair value of nonvested convertible bonds at January 1, 2007 was 2,203,995 and 7.84,
respectively, and at December 31, 2007 was 1,867,750 and 9.73, respectively.



The total number of convertible bonds vested during the year ended December 31, 2007, 2006, and 2005 was 781,745, 606,749 and 443,001,
respectively, and the related weighted-average grant date fair value was 6.90, 5.25 and 5.10, respectively.



The total intrinsic value of convertible bonds exercised during the years 2007, 2006 and 2005 was 6,747,000, 1,892,000 and 27,000, respectively.



Cash received from the conversion of convertible bonds as of
December 31, 2007, 2006, and 2005 was 1,864,000, 677,000 and 31,000, respectively.



The fair value of each convertible bond is estimated at grant date. GPC Biotech used a Monte Carlo simulation to estimate fair values for all awards granted since
January 1, 2006.



The fair value of the Companys convertible
bonds is calculated using the same assumptions as those used for our stock options. As provided for by SFAS 123(R), the Company recognizes compensation cost on a straight-line basis over the requisite service period for each tranche of the award as
if the award was, in-substance, multiple awards. Derived service period approximates 5-7 years and represents an estimate of the period when market condition is expected to be satisfied.



For convertible bonds issued during 2007, 2006 and 2005, total compensation cost was 8,177,000, 10,450,000 and 4,410,000, respectively, which is being recognized over the requisite



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service period of those instruments. Compensation cost related to convertible bonds included in the statements of operations was 3,037,000, 4,462,000 and 3,691,000 in 2007, 2006 and 2005, respectively. The decrease in compensation cost for 2007 was mainly due to the increase in actual forfeitures as discussed above.



As of December 31, 2007, there was 15,586,000 of total
unrecognized compensation cost related to non-vested share-based compensation arrangements granted under the Plans. The weighted average period over which these compensation cost will be recognized is approximately 59 months.



The following table represents weighted-average price and contractual life information
regarding significant fully vested convertible bonds and convertible bonds expected to vest at December 31, 2007:



|                                 |  |                                              |  |                                         |       |                                                     |     |        |           |                                  |   |                                                     |  |    
|-------------------------------- |  | -------------------------------------------- |  | --------------------------------------- | ----- | --------------------------------------------------- | --- | ------ | --------- | -------------------------------- | - | --------------------------------------------------- |  | ---
|                                 |  | Convertible Bonds Outstanding andExercisable |  | Convertible Bonds Outstanding andVested
|Range of Exercise Prices in Euro |  | Number                                       |  | Weighted- Average Exercise Price        |       | Weighted- Average Remaining Contractual Life(Years) |     | Number |           | Weighted- Average Exercise Price |   | Weighted- Average Remaining Contractual Life(Years)
|1.16 -   4.36                    |  | 49,125                                       |  |                                        | 4.36  |                                                     | 4.7 |        | 49,125    |                                  |  | 4.36                                                |  | 4.7
|4.87 -   5.77                    |  | 199,220                                      |  |                                        | 5.30  |                                                     | 5.4 |        | 199,220   |                                  |  | 5.30                                                |  | 5.4
|9.33 - 10.38                     |  | 365,000                                      |  |                                        | 10.16 |                                                     | 7.5 |        | 365,000   |                                  |  | 10.16                                               |  | 7.5
|10.67 - 10.90                    |  | 615,000                                      |  |                                        | 10.87 |                                                     | 6.9 |        | 615,000   |                                  |  | 10.87                                               |  | 6.9
|16.03 - 21.30                    |  | -                                            |  |                                         | -     |                                                     | -   |        | 269,250   |                                  |  | 16.78                                               |  | 8.9
|                                 |  |                                              |  |                                         |       |                                                     |     |        |           |                                  |   |                                                     |  |    
|                                 |  | 1,228,345                                    |  |                                        | 9.50  |                                                     | 6.8 |        | 1,497,595 |                                  |  | 10.81                                               |  | 7.1
|                                 |  |                                              |  |                                         |       |                                                     |     |        |           |                                  |   |                                                     |  |    



The aggregate intrinsic value
for fully vested convertible bonds as of December 31, 2007, 2006 and 2005 was 0, 6,242,000 and 3,029,000, respectively. The aggregate fair value of shares vested during the year ended December 31, 2007, 2006 and 2005 was
 5,083,000, 3,186,000 and 2,261,000, respectively.



The
aggregate intrinsic value for fully vested convertible bonds exercisable as of December 31, 2007, 2006 and 2005 was 0, 4,646,000 and 2,999,000, respectively.



Upon the conversion of convertible bonds, the Company issues new shares by way of a capital increase.



Stock Appreciation Rights



Starting in 2004, the Company issued SARs to members of the Supervisory Board and to certain members of the senior management team.
The SARs vest upon the achievement of certain performance conditions which are described below. In the case of the senior management, if the holders employment terminates before the actual vesting event of the rights, the SARs will be
cancelled without any compensation. Supervisory Board members, whose board membership ends prior to the vesting, will get compensated pro-rated, based on the length of the term of their office in proportion to the full holding period. The SARs vest
immediately upon the occurrence of the individual performance condition and the payment becomes due 100 calendar days after that date. In case of a change in control of the Company, each holding period will end on the date of effectiveness of the
change of control.



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As the SARs will be settled in cash, they are accounted for as liability awards when the achievement of the
performance condition becomes probable. The fair value of SARs is estimated on the grant date and revalued at each subsequent reporting date.



The following table summarizes the stock appreciation rights outstanding as of December 31, 2007:



|              |  |            |       |         |           |                   |                                                                                                 
|------------- |  | ---------- | ----- | ------- | --------- | ----------------- | ------------------------------------------------------------------------------------------------
|Grant Date    |  | GrantPrice |       | Number* |           | Vesting Condition
|Sept 1, 2004  |  |           | 10.22 |         | 86,250    |                   | First approval of satraplatin either by FDA or EMEA                                             
|Sept 30, 2004 |  |           | 10.97 |         | 125,000   |                   | EMEA approval of satraplatin                                                                    
|Sept 30, 2004 |  |           | 10.97 |         | 250,000   |                   | FDA approval of satraplatin                                                                     
|July 1, 2005  |  |           | 9.03  |         | 86,250    |                   | Approval of satraplatin by FDA and EMEA                                                         
|Sept 30, 2005 |  |           | 10.38 |         | 100,000   |                   | Approval of satraplatin by FDA and EMEA                                                         
|Aug 1, 2006   |  |           | 11.07 |         | 83,750    |                   | Acceptance of NDA for satraplatin by FDA other than for HRPC                                    
|Aug 28, 2006  |  |           | 10.94 |         | 25,000    |                   | FDA approval of satraplatin                                                                     
|Aug 28, 2006  |  |           | 10.94 |         | 25,000    |                   | Dosing of first patient in 2ndregistration trial for satraplatin                                
|Oct 31, 2006  |  |           | 16.03 |         | 103,750   |                   | Full (not-accelerated) FDA approval of satraplatin                                              
|Oct 31, 2006  |  |           | 16.03 |         | 103,750   |                   | Dosing of first patient in 2ndregistration trial for satraplatin                                
|Jun 08, 2007  |  |           | 21.03 |         | 83,750    |                   | Acceptance of NDA for satraplatin by FDA other than for HRPC (hormone resistant prostate cancer)
|              |  |            |       |         |           |                   |                                                                                                 
|Total**       |  |            |       |         | 1,072,500 |                   |                                                                                                 
|              |  |            |       |         |           |                   |                                                                                                 



|* | A member of the Supervisory Board, who holds 35,000 SARs, resigned in 2007. Future payout, if any, of these SARs will be pro-rated based on the length of the members office tenure in
proportion to the full holding period.
|- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|** | Amount excludes 4,000 SARs that do not have performance conditions.
|-- | -------------------------------------------------------------------



At December 31, 2007 and 2006, the Company has determined that only the dosing of the first patient in a second registrational trial for satraplatin was
probable and therefore the payout for a total of 128,750 SARs is deemed probable. The liability for the value of these SARs in 2007 was 33,000 compared to 151,000 in 2006, thus resulting in a decrease of 118,000 in compensation expense in
2007. The compensation cost is recognized over the implicit service period, which is the period from the date of grant until the estimated date of achievement of the performance condition. In addition, other expenses in the amount of 18,000 were recognized in 2006 for SARs without performance conditions which have been fully vested. The value of these SARs, however, was zero in 2007.



The amount of unrecognized compensation cost for those stock appreciation rights was
6,000 at December 31, 2007. There was no liability or expense recognized prior to 2006 for SARs, as none of the performance conditions were considered
probable at the time.



No payments have ever been made to any SAR holders
as their rights have not yet vested.



Under SFAS 123, liability
instruments had been measured at intrinsic value. However, SFAS 123(R), as adopted at the beginning of 2006, requires liability awards to be measured at fair value. The weighted-average grant date fair value of stock appreciation rights granted
during the year 2007 approximates to 0.55. The weighted average exercise price of stock appreciation rights outstanding at beginning of year was 11.87. The weighted average exercise price of stock appreciation rights outstanding at the end of the year was 12.58. The weighted average exercise price of stock appreciation rights deemed probable was 15.85.



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As of December 31, 2007, there was 273,000 of total unrecognized compensation cost related to unvested, non-probable, SARs granted. That cost was not yet recognized since the vesting of the underlying liability instruments was not deemed probable at December 31,
2007.



The aggregate intrinsic value for stock appreciation rights
expensed during the year ended December 31, 2007 was 0.



The Company uses the Black-Scholes model to value SARs. Management considers the Black-Scholes model to be appropriate due to the relatively short expected life of
these awards. Furthermore, SARs do not include market conditions. Significant assumptions used in the fair value model during the period with respect to the Companys SARs are summarized below:



|                            |  |              |  |             |  |     
|--------------------------- |  | ------------ |  | ----------- |  | ----
|                            |  | December 31,
|                            |  | 2007         |  | 2006        |  | 2005
|Expected dividend yield (%) |  | -            |  | -           |  | -   
|Risk-free interest rate (%) |  | 3.81-4.02    |  | 3.76-4.12   |  | -   
|Expected volatility (%)     |  | 56.98-105.01 |  | 41.48-68.04 |  | -   
|Expected life (in years)    |  | 0.75-5.92    |  | 0.63-6.92   |  | -   





The Company estimated expected volatility based on the historical realized volatility of the Companys stock over the individual estimated term of the SARs at
the date of grant. The risk-free rate for periods within the contractual life of the option is based on the German government bond yield curve in effect at the time of grant.



16. Income Taxes



The Companys loss before income taxes for the years ended December 31 arose in the following jurisdictions (in thousand ):



|                         |  |        |  |        |  |       
|------------------------ |  | ------ |  | ------ |  | ------
|                         |  | 2007   |  | 2006   |  | 2005  
|Germany                  |  | 40,113 |  | 42,543 |  | 46,716
|Other                    |  | 29,132 |  | 21,470 |  | 15,491
|                         |  |        |  |        |  |       
|Loss before income taxes |  | 69,245 |  | 64,013 |  | 62,207
|                         |  |        |  |        |  |       



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Deferred tax liabilities and assets are comprised of the following at December 31 (in thousand ):



|                                                 |  |          |   |  |          |  
|------------------------------------------------ |  | -------- | - |  | -------- | -
|                                                 |  | 2007     |   |  | 2006*    |  
|Deferred Tax Assets:                             |  |          |   |  |          |  
|Net operating loss carryforwards                 |  | 92,548   |   |  | 89,809   |  
|Research and development tax credits             |  | 9,582    |   |  | 9,321    |  
|Deferred revenue                                 |  | 4,375    |   |  | 4,663    |  
|Accrued expenses and losses                      |  | 4,718    |   |  | 4,802    |  
|Intangible Assets                                |  | 689      |   |  | 17       |  
|Property and Equipment                           |  | 397      |   |  | 202      |  
|Other                                            |  | 78       |   |  | 96       |  
|Valuation Allowance                              |  | (112,225 | ) |  | (108,760 | )
|                                                 |  |          |   |  |          |  
|                                                 |  | 162      |   |  | 150      |  
|                                                 |  |          |   |  |          |  
|Deferred Tax Liabilities:                        |  |          |   |  |          |  
|Intangible assets                                |  | (67      | ) |  | (102     | )
|Marketable securities and short-term investments |  | (14      | ) |  | (32      | )
|Accrued Compensation                             |  | -        |   |  | -        |  
|Property and Equipment                           |  | (81      | ) |  | -        |  
|Other                                            |  | -        |   |  | (16      | )
|                                                 |  |          |   |  |          |  
|Net deferred taxes                               |  | -        |   |  | -        |  
|                                                 |  |          |   |  |          |  



|* | The 2006 amounts in this table have been adjusted to reflect the Federal benefit of State taxes.
|- | ------------------------------------------------------------------------------------------------



The reconciliation of income tax computed at the statutory rate applicable to the Companys income tax expense for the years ended
December 31 is as follows (in thousands of , except percent):



|                                                        |  |         |   |  |         |    |  |         |   |  |         |    |  |         |   |  |         |   
|------------------------------------------------------- |  | ------- | - |  | ------- | -- |  | ------- | - |  | ------- | -- |  | ------- | - |  | ------- | --
|                                                        |  | 2007    |   |  | 2006    |    |  | 2005    |  
|                                                        |  | Amount  |   |  | Percent |    |  | Amount  |   |  | Percent |    |  | Amount  |   |  | Percent |   
|German tax benefit                                      |  | (24,855 | ) |  | 35.9    | %  |  | (22,981 | ) |  | 35.9    | %  |  | (24,497 | ) |  | 39.4    | % 
|Costs associated with equity offering                   |  | 1,006   |   |  | (1.5    | )% |  | -       |   |  | -       | %  |  | -       |   |  | -       | % 
|Non-deductible expenses and others                      |  | 670     |   |  | (1.0    | )% |  | 2,283   |   |  | (3.6    | )% |  | (4,170  | ) |  | 6.7     | % 
|Deductibility of federal tax and local German trade tax |  | -       |   |  | -       | %  |  | 7,539   |   |  | (11.8   | )% |  | -       |   |  | -       | % 
|Research and development tax credit                     |  | (1,320  | ) |  | 1.9     | %  |  | (1,633  | ) |  | 2.6     | %  |  | (1,284  | ) |  | 2.0     | % 
|Post tax audit adjustment of NOL                        |  | -       |   |  | -       | %  |  | 8,210   |   |  | (12.8   | )% |  | -       |   |  | -       | % 
|Tax based adjustment accrued expenses                   |  | -       |   |  | -       | %  |  | (1,959  | ) |  | 3.1     | %  |  | -       |   |  | -       | % 
|Different tax rate in other countries                   |  | 262     |   |  | (0.4    | )% |  | (1,795  | ) |  | 2.8     | %  |  | (1,132  | ) |  | 1.8     | % 
|Change in valuation allowance                           |  | 24,237  |   |  | (35.0   | )% |  | 10,336  |   |  | (16.2   | )% |  | 31,083  |   |  | (49.9   | )%
|                                                        |  |         |  
|Income tax expense                                      |  | -       |   |  | -       | %  |  | -       |   |  | -       | %  |  | -       |   |  | -       | % 
|                                                        |  |         |  



The Company has certain deferred
tax assets as a result of several years of losses from operations. Realization of deferred tax assets is dependent upon future taxable income, if any, the timing and amount of which is uncertain. As a result, the Company has a full valuation
allowance for those deferred tax assets and has not recognized any benefits from tax positions in earnings. Accordingly, the adoption of the provisions of FIN 48 did not have a material impact on the Companys financial statements.



For fiscal years ending in 2004 and beyond, a new law is in effect restricting the
use of net operating loss (NOL) carryforwards for German corporation tax and trade tax purposes. The



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Companys maximum NOL carryforward that may be utilized in any one year is restricted to 60% of the annual taxable income above 1.0 million. For fiscal years ending before 2004, a NOL carryforward could be utilized without any restrictions to reduce the annual corporate income and trade tax taxable income to 0. The amount of NOL carryforwards for German corporation and trade tax purposes is 172,691,000 and 171,868,000, respectively. In general, these NOLs do not expire.



As a result of an ownership change in the U.S. subsidiary in 2000, the Company has a
limitation of 1,189,000 per year for the losses incurred prior to the change in ownership, on the amount of income that is available to be offset by federal
NOL carryforwards generated in the U.S. The Company has 29,553,000 of net operating losses carried forward that are subject to this limitation. Generally, federal
net operating losses generated in the U.S. can be carried back two years and forward twenty years. For net operating losses in tax years beginning before August 6, 1997, taxpayers can carry back a net operating loss three years and forward
fifteen years. The Company has 107,081,000 of federal NOL carryforwards subject to a twenty year carryforward and 17,844,000 subject to a fifteen year carryforward. Federal NOL carryforwards generated in the U.S. expire at various times between the years 2008 and 2027.



The Company has 167,355,000 of state net operating losses that expire at various times between the years of 2008 and 2014. The Company has 83,677,000 of state NOL
carryforwards subject to a five-year carryforward and 83,678,000 subject to a seven-year carryforward.



The Companys U.S. subsidiary had federal research and development credits of
5,590,000 and state research and development credits of 3,929,000 at
December 31, 2007.



Because the Company has historically incurred
net operating losses, current and deferred tax expense for the years ending December 31, 2007 and 2006 was  0.



No income taxes are provided for on undistributed earnings of the foreign subsidiary
where those earning are considered to be permanently invested. Total undistributed earnings in such foreign subsidiaries amounted to approximately  0.



As stated in Footnote 3, effective January 1, 2007, the Company adopted FIN 48,
Accounting for Uncertainty in Income Taxes  an interpretation of FAS 109, which was issued in July 2006. FIN 48 clarifies the accounting for uncertainty in income taxes and prescribes a recognition threshold and measurement attributes
for the financial statement recognition and measurement of a tax position taken or expected to be taken in a tax return. Also, as stated in Footnote 3, in 2007 the Company adopted FIN 48-1, Definition of Settlement in FASB Interpretation
No. 48, retroactive to the adoption of FIN 48. FIN 48-1 provides guidance on how an enterprise should determine whether a tax position is effectively settled for the purpose of recognizing previously unrecognized tax benefits.



Unrecognized tax benefits amounted to 0 at December 31, 2007. We do not expect unrecognized tax benefits to change significantly over the next 12 months.



The Company accounts for penalties or interest related to uncertain tax positions as part of its provision for income taxes. Due
to the Companys net operating loss carry-forwards the adjustment related to the FIN 48 liability would not expect to result in a cash tax liability. Accordingly, the Company has not accrued for penalties or interest for both the U.S. (both
Federal and State) and Germany as of December 31, 2007 and 2006. Also, due to the Companys net operating loss carry-forwards, the Company does not believe any of its unrecognized tax benefits would have an impact on the effective tax
rate.



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We file income tax returns in various jurisdictions with varying statutes of limitations. As of December 31,
2007, the statute of limitations for income tax audits in Germany remains open for the tax years ended on or after December 31, 2004. The statute of limitations for income tax audits in the US and the Commonwealth of Massachusetts remains open
for the tax years ended on or after December 31, 2001, and the statute of limitations for income tax audits in the State of New Jersey remains open for the tax years ended on or after December 31, 2005.



During 2007, the State of New Jersey conducted an examination of the Company relating
to tax years ended December 31, 2002 through 2005. Upon completion of this examination, the Company did not pay any amounts relating to income taxes, including penalties or interest. No other tax jurisdictions were under examination as of
December 31, 2007.



The Company accounts for penalties and interest
in the period in which the item(s) occur and records the expense to general and administrative expenses.



17. Loss per Share



Basic loss per ordinary
share is based on the weighted-average number of ordinary shares outstanding. For the years ended December 31, 2007, 2006 and 2005, diluted net loss per ordinary share was the same as basic net loss per ordinary share as the inclusion of
weighted-average ordinary shares issuable upon exercise of stock options and convertible bonds would be antidilutive. The number of potentially dilutive shares excluded from the loss per share calculation due to their antidilutive effect was
2,626,585, 3,371,567 and 2,305,008 for the years ended December 31, 2007, 2006 and 2005, respectively.



The following table sets forth the computation of basic and diluted loss per share (in thousand , except share and per share data):



|                                                                                         |  |            |   |  |            |   |  |            |  
|---------------------------------------------------------------------------------------- |  | ---------- | - |  | ---------- | - |  | ---------- | -
|                                                                                         |  | 2007       |   |  | 2006       |   |  | 2005       |  
|Numerator:                                                                               |  |            |   |  |            |   |  |            |  
|Net loss                                                                                 |  | (69,245    | ) |  | (64,013    | ) |  | (62,207    | )
|                                                                                         |  |            |  
|Denominator:                                                                             |  |            |   |  |            |   |  |            |  
|Denominator for basic and diluted earnings per share  weighted-average number of shares |  | 36,181,956 |   |  | 32,840,480 |   |  | 29,877,348 |  
|                                                                                         |  |            |  
|Basic and diluted loss per share                                                         |  | (1.91      | ) |  | (1.95      | ) |  | (2.08      | )
|                                                                                         |  |            |  



18. Shareholders Equity



Ordinary Shares



The holders of the Companys ordinary shares are entitled to one vote for each share held at all meetings of shareholders.
Dividends and distribution of assets of the Company in the event of liquidation are subject to the rights of any then-outstanding ordinary shares. The Company has never declared or paid dividends on any of its ordinary shares and does not expect to
do so in the foreseeable future.



Authorized Shares



To assist management in undertaking strategic activities and/or capital increases and
to service the stock option plans and convertible bonds, the shareholders of the Company have authorized the



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future issuance of ordinary shares in specific circumstances with the permission of the Supervisory Board. At December 31, 2007, the total number of ordinary
shares potentially issuable was 33,546,297. The number of ordinary shares authorized for exercise of stock options and convertible bonds was 4,471,925 and 4,674,372, respectively. The number of ordinary shares authorized for the purpose of potential
merger and acquisition activities, in-licensing activities and future capital increases is 15,000,000. The number of ordinary shares authorized for the purposes of potential warrants, options, or convertible debt issuances for financing purposes is
9,400,000. Issuances may be subject to statutory subscription rights of existing shareholders.



Exercise of Stock Options and Convertible Bonds



During 2007, 2006 and 2005, several holders of stock options and convertible bonds exercised some of their fully vested options and convertible bonds receiving 1,376,822, 883,687 and 99,465 ordinary shares, respectively.



At December 31, 2006, members of the Management Board and employees of the Company
had subscribed to 53,500 ordinary shares with a total value of 334,370, which has been included in shareholders equity. The subscribed shares represent
amounts paid for exercises of stock options for which ordinary shares have not been issued at December 31, 2006. During 2007, all of the subscribed shares from 2006 were issued, and at December 31, 2007, the Company did not have any
subscribed shares.



Issuance of Shares in a Private Placement



On January 24, 2007, the Company issued 1,564,587 new ordinary shares at 21.50 per share for a total gross amount of 33.6 million through a
private placement. GPC Biotech received the proceeds upon registration of the corresponding capital increase in the German commercial register in February 2007.



On February 23, 2006 GPC Biotech issued 2,860,000 new ordinary shares at 12.67 per share in a private placement involving two family investment companies. The total investment amounted to 36,236,000 and was recorded in
shareholders equity net of costs of transaction of 156,000.



Accumulated Other Comprehensive Loss



The balances of the components of accumulated other comprehensive loss as of December 31, 2007, 2006 and 2005 were as follows (in thousand ):



|                                                        |  |              |   |  |        |   |  |        |  
|------------------------------------------------------- |  | ------------ | - |  | ------ | - |  | ------ | -
|                                                        |  | December 31, |  
|                                                        |  | 2007         |   |  | 2006   |   |  | 2005   |  
|Unrealized (loss)/gain on available-for-sale securities |  | (162         | ) |  | 428    |   |  | (187   | )
|Accumulated translation adjustments                     |  | (4,878       | ) |  | (2,183 | ) |  | (1,906 | )
|                                                        |  |              |  
|Total accumulated other comprehensive loss              |  | (5,040       | ) |  | (1,755 | ) |  | (2,093 | )
|                                                        |  |              |  



19. Employee Benefit Plan



GPC Biotech Inc., the Companys US subsidiary, has a defined contribution plan
qualified under the provisions of the Internal Revenue Code section 401(k). All individuals who are employed on a full time permanent basis by GPC Biotech Inc. are immediately eligible for enrollment in the plan. GPC Biotech Inc. increased the
Companys contribution to the plan to 100% from 50%, which was in place in prior years, of the first 4% of annual compensation contributed by each participant.



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Contributions are fully vested immediately. Costs of the plan, including the matching contribution, charged to operating expenses amounted to 478,000, 169,000, and 144,000 in 2007, 2006 and 2005, respectively.



20.
Subsequent event



In February 2008, the Company announced a corporate
restructuring to sharpen the Companys focus on oncology clinical development efforts and to further reduce costs. The restructuring was mainly focused on the Companys early-stage research activities in Munich and will result in a
reduction in the total workforce of approximately 38% or 38 employees. The Company currently estimates the cost of the restructuring to total approximately 1.2 million, which is primarily related to employee severance and termination benefits and other closing costs. The Company expects such costs to continue through December 2008, a majority of which will be recognized in the
statement of operations in accordance with SFAS 146 during the first quarter of 2008.



In addition, the Company announced that, by mutual consent, Elmar Maier, Ph.D., Chief Operating Officer/Martinsried and Senior Vice President, Business Development, and Sebastian Meier-Ewert, Ph.D., Senior Vice President and
Chief Scientific Officer retired from their positions on the Management Board of the Company to allow for an appropriate resizing of the Board, given the reduced size of the Company. Both Dr. Maier and Dr. Meier-Ewert remain dedicated
to the Company as advisors.



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