EXHIBIT 12.1

                                  CERTIFICATION

I, Izhak Tamir certify that:

     1.   I have reviewed this annual report on Form 20-F of Tikcro Technologies
          Ltd.:

     2.   Based on my knowledge, this report does not contain any untrue
          statement of a material fact or omit to state a material fact
          necessary to make the statements made, in light of the circumstances
          under which such statements were made, not misleading with respect to
          the period covered by this report;

     3.   Based on my knowledge, the financial statements, and other financial
          information included in this report, fairly present in all material
          respects the financial condition, results of operations and cash flows
          of the company as of, and for, the periods presented in this report;

     4.   I am responsible for establishing and maintaining disclosure controls
          and procedures (as defined in Exchange Act Rules 13a-15(e) and
          15d-15(e)) for the company and have:

               a.   designed such disclosure controls and procedures, or caused
                    such disclosure controls and procedures to be designed under
                    my supervision, to ensure that material information relating
                    to the company, including its consolidated subsidiaries, is
                    made known to me by others within those entities,
                    particularly during the period in which this report is being
                    prepared;

               b.   evaluated the effectiveness of the company's disclosure
                    controls and procedures and presented in this report my
                    conclusions about the effectiveness of the disclosure
                    controls and procedures, as of the end of the period covered
                    by this report based on such evaluation; and

               c.   disclosed in this report any change in the company's
                    internal control over financial reporting that occurred
                    during the period covered by the annual report that has
                    materially affected, or is reasonably likely to materially
                    affect, the company's internal control over financial
                    reporting; and

     5.   I have disclosed, based on our most recent evaluation of internal
          control over financial reporting, to the company's auditors and the
          audit committee of the company's board of directors (or persons
          performing the equivalent functions):

               a.   all significant deficiencies and material weaknesses in the
                    design or operation of internal control over financial
                    reporting which are reasonably likely to adversely affect
                    the company's ability to record, process, summarize and
                    report financial information; and

<Page>

               b.   any fraud, whether or not material, that involves management
                    or other employees who have a significant role in the
                    company's internal control over financial reporting.


Dated: June 21, 2004                            /s/ Izhak Tamir
                                                ---------------
                                                Izhak Tamir
                                                Principal Executive Officer and
                                                Principal Financial Officer