Exhibit 4.11



MASTER SECURITY AGREEMENT

No. 4081047

Dated as of February 26, 2004 (Agreement)





THIS AGREEMENT is between Oxford Finance Corporation (together with its successors and assigns, if any, Secured Party) and Renovis, Inc.(Debtor). Secured Party has an office at 133
N. Fairfax Street, Alexandria, VA 22314. Debtor is a corporation organized and existing under the laws of the state of Delaware. Debtors mailing address and chief place of business is Two Corporate Drive, South San Francisco, CA 94080.





|1. | CREATION OF SECURITY INTEREST.
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Debtor grants to Secured Party, its successors and assigns, a security interest in and against all property listed on any collateral schedule now or in
the future annexed to or made a part of this Agreement (Collateral Schedule), and in and against all additions, attachments, accessories and accessions to such property, all substitutions, replacements or exchanges therefor, and
all insurance and/or other proceeds thereof (all such property is individually and collectively called the Collateral). This security interest is given to secure the payment and performance of all debts, obligations and
liabilities, now existing or arising in the future, under the Promissory Notes from time to time identified on any Collateral Schedule (collectively Notes and each a Note), and any renewals, extensions and
modifications of such debts, obligations and liabilities (such Notes, debts, obligations and liabilities are called the Indebtedness). Unless otherwise provided by applicable law, notwithstanding anything to the contrary contained
in this Agreement, to the extent that Secured Party asserts a purchase money security interest in any items of Collateral (PMSI Collateral): (i) the PMSI Collateral shall secure only that portion of the Indebtedness which has been
advanced by Secured Party to enable Debtor to purchase, or acquire rights in or the use of such PMSI Collateral (the PMSI Indebtedness), and (ii) no other Collateral shall secure the PMSI Indebtedness.





|2. | REPRESENTATIONS, WARRANTIES AND COVENANTS OF DEBTOR.
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Debtor represents, warrants and covenants as of the date of this Agreement and as of the date of each Collateral Schedule that:



| | (a) | Debtors exact legal name is as set forth in the preamble of this Agreement (or as set forth in the most recent notice delivered to Secured Party pursuant to Section 5.(a)(i))
and Debtor is, and will remain, duly organized, existing and in good standing under the laws of the State set forth in the preamble of this Agreement (or as set forth in the most recent notice delivered to Secured Party pursuant to Section
5.(a)(ii)), has its chief executive offices at the location specified in the preamble (or as set forth in the most recent notice delivered to Secured Party pursuant to Section 5.(a)(iii)), and is, and will remain, duly qualified and licensed in
every jurisdiction wherever necessary to carry on its business and operations (except where a failure to be so qualified would not have a material adverse effect on the Debtors financial condition or operations);
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| | (b) | Debtor has adequate power and capacity to enter into, and to perform its obligations under this Agreement, each Note and any other documents evidencing, or given in connection with,
any of the Indebtedness (all of the foregoing are called the Debt Documents);
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| | (c) | This Agreement and the other Debt Documents have been duly authorized, executed and delivered by Debtor and constitute legal, valid and binding agreements enforceable in accordance
with their terms, except to the extent that the enforcement of remedies may be limited under applicable bankruptcy and insolvency laws;
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| | (d) | No approval, consent or withholding of objections is required from any governmental authority or instrumentality with respect to the entry into, or performance by Debtor of any of
the Debt Documents, except any already obtained;
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| | (e) | The entry into, and performance by, Debtor of the Debt Documents will not (i) violate any of the organizational documents of Debtor or any judgment, order, law or regulation
applicable to Debtor, or (ii) result in any breach of or constitute a default under any material contract to which Debtor is a party, or result in the creation of any lien, claim or encumbrance on any material portion of Debtors property
(except for liens in favor of Secured Party) pursuant to any material indenture, mortgage, deed of trust, bank loan, credit agreement, or other agreement or instrument to which Debtor is a party;
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| | (f) | There are no suits or proceedings pending in court or before any commission, board or other administrative agency against or affecting Debtor which could, in the aggregate, have a
material adverse effect on Debtor, its business or operations, or its ability to perform its obligations under the Debt Documents, nor does Debtor have reason to believe that any such suits or proceedings are threatened;
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| | (g) | All financial statements delivered to Secured Party in connection with the Indebtedness have been prepared in accordance with generally accepted accounting principles (subject to
normal quarterly adjustments and the absence of footnotes), and since the date of the most recent financial statement, there has been no material adverse change in Debtors financial condition;
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| | (h) | The Collateral is not, and will not be, used by Debtor for personal, family or household purposes;
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| | (i) | The Collateral is, and will remain, in good condition and repair (reasonable wear and tear excepted) and Debtor will not be negligent in its care and use;
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| | (j) | All of the tangible Collateral is located at the locations set forth on each Collateral Schedule. Debtor shall give the Secured Party 30 days prior written notice of any relocation
of any Collateral;
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| | (k) | Debtor is, and will remain, the sole and lawful owner, and in possession of, the Collateral, and has the sole right and lawful authority to grant the security interest described in
this Agreement;
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| | (l) | The Collateral is, and will remain, free and clear of all liens, claims and encumbrances of any kind whatsoever, except for (i) liens in favor of Secured Party, (ii) liens for taxes
not yet due or for taxes being contested in good faith and which do not involve, in the judgment of Secured Party, any risk of the sale, forfeiture or loss of any of the Collateral, and (iii) inchoate material mens, mechanics,
repairmens and similar liens arising by operation of law in the normal course of business for amounts which are not delinquent (all of such liens are called Permitted Liens).
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| | (m) | All federal, state and local tax returns required to be filed by Debtor have been filed with the appropriate governmental agencies and all taxes due and payable by Debtor have been
timely paid. Debtor will pay when due all taxes, assessments and other liabilities except as contested in good faith and by appropriate proceedings and for which adequate reserves have been established;
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| | (n) | No event or condition exists under any material agreement, instrument or document to which Debtor is a party or may be subject, or by which Debtor or any of its properties are
bound, which constitutes a default or an event of default thereunder, or will, with the giving of notice, passage of time, or both, would constitute a default or event of default thereunder except to the extent contested in good faith and by
appropriate proceedings and for which adequate reserves have been established
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| | (o) | All reports, certificates, schedules, notices and financial information submitted by Debtor to the Secured Party pursuant to this Agreement shall be certified as true and correct in
all material respects by the president or chief financial officer of Debtor;
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| | (p) | Debtor shall give the Secured Party prompt written notice of any event, occurrence or other matter which has resulted or may result in a material adverse change in its financial
condition, business operations, product development, technology, or business or contractual relations with third parties of Debtor which would impair the ability of Debtor to perform its obligations hereunder or of Secured Party to enforce the
Indebtedness or realize upon the Collateral;
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| | (q) | Debtor has previously delivered to the Secured Party a certificate signed by the Debtor and entitled Perfection Certificate (the Perfection
Certificate). The Debtor represents and warrants to the Secured Party as follows: (a) the Debtors exact legal name is that indicated on the Perfection Certificate and on the signature page hereof, (b) the Debtor is an organization of
the type, and is organized in the jurisdiction set forth in the Perfection Certificate, (c) the Perfection Certificate accurately sets forth the Debtors organizational identification number or accurately states that the Debtor has none, (d)
the Perfection Certificate accurately sets forth the Debtors place of business or, if more than one, its chief executive office, as well as the Debtors mailing address, if different, (e) all other information set forth on the Perfection
Certificate pertaining to the Debtor is accurate and complete in all material respects, and (f) that there has been no change in any information provided in the Perfection Certificate since the date on which it was executed by the Debtor which would
result in a material adverse effect on the Secured Partys security interest in any material portion of the Collateral and priority thereof unless notice has been provided by Debtor to Secured Party.
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|3. | COLLATERAL.
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| | (a) | Until the declaration and during the continuance of any Event of Default, Debtor shall remain in possession of the Collateral; except that Secured Party shall have the right to
possess (i) any chattel paper or instrument that constitutes a part of the Collateral, and (ii) any other Collateral in which Secured Partys security interest may be perfected only by possession. Secured Party may inspect any of the Collateral
during normal business hours after giving Debtor reasonable prior notice.
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| | (b) | Debtor shall (i) use the Collateral only in its trade or business, (ii) maintain all of the Collateral in good operating order and repair, normal wear and tear excepted, (iii) use
and maintain the Collateral only in compliance in all material respects with manufacturers recommendations and all applicable laws, and (iv) keep all of the Collateral free and clear of all liens, claims and encumbrances (except for Permitted
Liens).
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| | (c) | Secured Party does not authorize and Debtor agrees it shall not (i) part with possession of any of the Collateral (except to Secured Party or for maintenance and repair), (ii)
remove any of the Collateral from the continental United States, or (iii) sell, rent, lease, mortgage, license, grant a security interest in or otherwise transfer or encumber (except for Permitted Liens) any of the Collateral; provided,
however, the Debtor, with the consent of the Secured Party, is entitled to sell any portion of the Collateral which constitutes equipment that is either obsolete or worn-out, a determination to be made in the Secured Partys reasonable
discretion, provided, that with respect to any equipment purchased with monies made available to Debtor through an Advance, Debtor shall remit a portion of the such proceeds to the Secured Party in an amount equal to the balance of any unpaid
principal associated with such equipment.
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| | (d) | Debtor shall pay promptly when due all taxes, license fees, assessments and public and private charges levied or assessed on any of the Collateral, on its use, or on this Agreement
or any of the other Debt Documents. At its option, Secured Party may discharge taxes, liens, security interests or other encumbrances at any time levied or placed on the Collateral and may pay for the maintenance, insurance and preservation of the
Collateral and effect compliance with the terms of this Agreement or any of the other Debt Documents. Debtor agrees to reimburse Secured Party, on demand, all costs and expenses incurred by Secured Party in connection with such payment or
performance and agrees that such reimbursement obligation shall constitute Indebtedness.
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| | (e) | Debtor shall, at all times, keep accurate and complete records of the Collateral, and Secured Party shall have the right to inspect and make copies of all of Debtors books and
records relating to the Collateral during normal business hours, after giving Debtor reasonable prior notice.
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| | (f) | Debtor agrees and acknowledges that any third person who may at any time possess all or any material portion of the Collateral shall be deemed to hold, and shall hold, the
Collateral as the agent of, and as pledge holder for, Secured Party. Secured Party may at any time give notice to any third person described in the preceding sentence that such third person is holding the Collateral as the agent of, and as pledge
holder for, the Secured Party.
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|4. | INSURANCE.
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| | (a) | As between the Debtor and Secured Party, Debtor shall at all times bear the entire risk of any loss, theft, damage to, or destruction of, any of the Collateral from any cause
whatsoever.
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| | (b) | Debtor agrees to keep the Collateral insured against loss or damage by fire and extended coverage perils, theft, burglary, and for any or all Collateral, which are vehicles, for
risk of loss by collision, and if requested by Secured Party, against such other risks as Secured Party may reasonably require. The insurance coverage shall be in an amount no less than the full replacement value of the Collateral, and deductible
amounts, insurers and policies shall be reasonably acceptable to Secured Party. Debtor shall deliver to Secured Party policies or certificates of insurance evidencing such coverage. Each policy shall name Secured Party as a loss payee, shall provide
for coverage to Secured Party regardless of the breach by Debtor of any warranty or representation made therein, shall not be subject to co-insurance, and shall provide that coverage may not be canceled or altered by the insurer except upon thirty
(30) days prior written notice to Secured Party. Debtor appoints Secured Party as its attorney-in-fact to make proof of loss, claim for insurance and adjustments with insurers, and to receive payment of and execute or endorse all documents, checks
or drafts in connection with insurance payments. Secured Party shall not act as Debtors attorney-in-fact unless an Event of Default is then continuing. Proceeds of insurance shall be applied, at the option of Secured Party, to repair or
replace the Collateral or to reduce any of the Indebtedness.
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|5. | REPORTS.
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| | (a) | Debtor shall promptly notify Secured Party of (i) any change in the name of Debtor, (ii) any change in the state of its incorporation or registration, (iii) any relocation of its
chief executive offices, (iv) any material portion of the Collateral being lost, stolen, missing, destroyed, materially damaged or worn out, or (v) any lien, claim or encumbrance other than Permitted Liens attaching to or being made against any
material portion of the Collateral.
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| | (b) | Debtor will deliver to Secured Party within ninety (90) days of the close of each fiscal year of Debtor, Debtors complete financial statements including a balance sheet,
income statement, statement of shareholders equity and statement of cash flows, each prepared in accordance with generally accepted accounting principles consistently applied, certified by a recognized firm of certified public accountants
satisfactory to Secured Party. Debtor will deliver to Secured Party copies of Debtors quarterly financial statements including a balance sheet, income statement and
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statement of cash flows, each prepared by Debtor in accordance with generally accepted accounting
principles (subject to normal quarterly adjustments and the absence of footnotes) consistently applied by Debtor and certified by Debtors chief financial officer, within ninety (90) days after the close of each of Debtors fiscal quarter.
In the event the Debtors corporate website does not include copies or access to its 10-Q and 10-K filings within 20 days after they are filed with the Securities and Exchange Commission (the SEC), the Debtor shall deliver to
Secured Party copies of such filings within 30 days after the dates on which they are filed with the Securities and Exchange Commission. Debtor will deliver to Secured Party promptly upon request of Secured Party, in form satisfactory to Secured
Party, such other and additional information as Secured Party may reasonably request from time to time.





|6. | FURTHER ASSURANCES.
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| | (a) | Debtor shall, upon reasonable request of Secured Party, furnish to Secured Party such further information, execute and deliver to Secured Party such documents and instruments
(including, without limitation, Uniform Commercial Code financing statements) and shall do such other acts and things as Secured Party may at any time reasonably request relating to the perfection or protection of the security interest created by
this Agreement or for the purpose of carrying out the intent of this Agreement. Without limiting the foregoing, Debtor shall cooperate and do all acts reasonably deemed necessary or advisable by Secured Party to continue in Secured Party a perfected
first security interest in the Collateral (subject to the Permitted Liens), and shall obtain and furnish to Secured Party any subordinations, releases, mortgagee waivers, or control agreements, and similar documents as may be from time to time
reasonably requested by, and in form and substance reasonably satisfactory to, Secured Party.
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| | (b) | Debtor shall perform any and all acts reasonably requested by the Secured Party to establish, maintain and continue the Secured Partys security interest and liens in the
Collateral, including but not limited to, executing or authenticating financing statements and such other instruments and documents when and as reasonably requested by the Secured Party. Debtor hereby authorizes Secured Party through any of Secured
Partys employees, agents or attorneys to file any and all financing statements, including, without limitation, any original filings, continuations, transfers or amendments thereof required to perfect Secured Partys security interest and
liens in the Collateral under the UCC without authentication or execution by Debtor. Debtor hereby irrevocably authorizes the Secured Party at any time and from time to time to file in any filing office in any Uniform Commercial Code jurisdiction
any initial financing statement(s) and amendments thereto that (a) indicate the Collateral (i) is subject to the Secured Partys security interest, regardless of whether any particular asset comprised in the Collateral falls within the scope of
Article 9 of the Uniform Commercial Code of the State or such jurisdiction, or (ii) as being of an equal or lesser scope or with greater detail, and (b) provide any other information required by part 5 of Article 9 of the Uniform Commercial Code of
the State or such other jurisdiction for the sufficiency or filing office acceptance of any financing statement or amendment, including whether the Debtor is an organization, the type of organization and any organization identification number issued
to the Debtor. The Debtor agrees to furnish any such information to the Secured Party promptly upon the Secured Partys reasonable request.
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| | (c) | Debtor shall indemnify and defend the Secured Party, its successors and assigns, and their respective directors, officers and employees, from and against all claims, actions and
suits (including, without limitation, related and reasonable attorneys fees) of any kind whatsoever arising, directly or indirectly, in connection with any of the Collateral except to the extent arising from the gross negligence or willful
misconduct of such Indemnified Party.
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|7. | DEFAULT AND REMEDIES.
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| | (a) | An Event of Default shall exist under this Agreement and each of the other Debt Documents if:
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| | (i) | Debtor breaches its obligation to pay within 3 days of when due any installment or other amount due or coming due under any of the Debt Documents;
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| | (ii) | Debtor, without the prior written consent of Secured Party or except where it is expressly authorized to do so hereunder, attempts to or does sell, rent, lease, license, mortgage,
grant a security interest in, or otherwise transfer or encumber (except for Permitted Liens) any of the Collateral and does not cure within 10 days;
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| | (iii) | Debtor breaches any of its insurance obligations under Section 4 and does not cure within 7 days;
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| | (iv) | Debtor breaches any material non-payment obligations under any of the Debt Documents and fails to cure that breach within thirty (30) days after written notice from Secured Party;
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| | (v) | Any warranty, representation or statement made by Debtor in any of the Debt Documents shall be false or misleading in any material respect;
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| | (vi) | Any material portion of the Collateral is subjected to attachment, execution, levy, seizure or confiscation in any legal proceeding or otherwise, or if any legal or administrative
proceeding is commenced against Debtor or any material portion of the Collateral, which in the good faith judgment of Secured Party subjects any material portion of the Collateral to a material risk of attachment, execution, levy, seizure or
confiscation and no bond is posted or protective order obtained to negate such risk;
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| | (vii) | Debtor has defaulted on a payment obligation to Secured Party under any agreement entered into by Debtor and Secured Party for which the applicable period for curing such default,
if any, has lapsed and Debtor is still in default;
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| | (viii) | Debtor dissolves, terminates its existence, becomes insolvent or ceases to do business as a going concern;
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| | (ix) | A receiver is appointed for all or of any part of the property of Debtor, or Debtor makes any assignment for the benefit of creditors;
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| | (x) | Debtor files a petition under any bankruptcy, insolvency or similar law, or any such petition is filed against Debtor and is not dismissed within sixty (60) days;
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| | (xi) | Debtors improper filing of an amendment or termination statement relating to a filed financing statement describing the Collateral.
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| | (xii) | Debtor shall merge with or consolidate into any other entity or sell all or substantially all of its assets or in any manner terminate its existence unless such successor entity
assumes the obligations of the Debtor under this Agreement and the Debt Documents;
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| | (xiii) | Without the prior written consent of Secured Party which consent shall not be unreasonably withheld or delayed, there shall be a change in the ownership of Debtors stock such
that Debtor is no longer subject to the reporting requirements of the Securities Exchange Act of 1934 or no longer has a class of equity securities registered under Section 12 of the Securities Act of 1933;
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| | (xiv) | Debtor defaults any applicable cure opportunity has lapsed and Debtor is still in default under any material financing arrangement between Debtor and a third party and such default
is reasonably expected to have a material adverse effect on the Debtors financial condition or operations; and
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| | (xv) | Secured Party shall have determined in its good faith, sole and reasonable judgment that there has been a material adverse change in the financial condition of Debtor which would
materially impair the ability of Debtor to perform its obligations hereunder or of Secured Party to enforce the Indebtedness or realize upon the Collateral.
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| | (b) | Upon the occurrence and during the continuance of an Event of Default the Secured Party, at its option, may declare any or all of the Indebtedness to be immediately due and payable,
without demand or notice to Debtor or any Guarantor. The accelerated obligations and liabilities shall bear interest (both before and after any judgment) until paid in full at the lower of twelve percent (12%) per annum or the maximum rate not
prohibited by applicable law.
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| | (c) | Secured Party shall have all of the rights and remedies of a Secured Party under the Uniform Commercial Code, and under any other applicable law. Without limiting the foregoing,
upon the occurrence and during the continuance of an Event of Default, Secured Party shall have the right to (i) notify any account debtor of Debtor or any obligor on any instrument which constitutes part of the Collateral to make payment to the
Secured Party, (ii) with or without legal process (to the extent permitted under applicable law), enter any premises where the Collateral may be and take possession of and remove the Collateral from the premises or store it on the premises, (iii)
sell the Collateral at public or private sale, in whole or in part, and have the right to bid and purchase at said sale, or (iv) lease or otherwise dispose of all or part of the Collateral, applying proceeds from such disposition to the obligations
then in default. Upon the occurrence and during the continuance of an Event of Default, if requested by Secured Party, Debtor shall promptly assemble the Collateral and make it available to Secured Party at a place to be designated by Secured Party,
which is reasonably convenient to both parties. Upon the occurrence and during the continuance of an Event of Default, Secured Party may also render any or all of the Collateral unusable at the Debtors premises and may dispose of such
Collateral on such premises without liability for rent or costs. Any notice that Secured Party is required to give to Debtor under the Uniform Commercial Code of the time and place of any public sale or the time after which any private sale or other
intended disposition of the Collateral is to be made shall be deemed to constitute reasonable notice if such notice is given to the last known address of Debtor at least five (5) days prior to such action. Upon the occurrence and during the
continuation of an Event of Default, Debtor hereby appoints Secured Party as Debtors attorney-in-fact, with full authority in Debtors place and stead and in Debtors name or otherwise, from time to time in Secured Partys sole
discretion, to take any action and to execute any instrument which Secured Party may deem necessary or advisable to accomplish the purpose of this Agreement.
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| | (d) | Proceeds from any sale or lease or other disposition shall be applied: first, to all reasonable costs of repossession, storage, and disposition including without limitation
reasonable attorneys, appraisers, and auctioneers fees; second, to discharge the obligations then in default; third, to discharge any other Indebtedness of Debtor to Secured Party, whether as obligor, endorser, guarantor, surety or
indemnitor; fourth, to expenses incurred in paying or settling liens and claims against the Collateral; and lastly, to Debtor, if there exists any surplus. Debtor shall remain fully liable for any deficiency.
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| | (e) | Debtor agrees to pay all reasonable attorneys fees and other costs incurred by Secured Party in connection with the enforcement, assertion, defense or preservation of Secured
Partys rights and remedies under this Agreement, or if prohibited by law, such lesser sum as may be permitted. Debtor further agrees that such fees and costs shall constitute Indebtedness.
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| | (f) | Secured Partys rights and remedies under this Agreement or otherwise arising are cumulative and may be exercised singularly or concurrently. Neither the failure nor any delay
on the part of the Secured Party to exercise any right, power or privilege under this Agreement shall operate as a waiver, nor shall any single or partial exercise of any right, power or privilege preclude any other or further exercise of that or
any other right, power or privilege. SECURED PARTY SHALL NOT BE DEEMED TO HAVE WAIVED ANY OF ITS RIGHTS UNDER THIS AGREEMENT OR UNDER ANY OTHER AGREEMENT, INSTRUMENT OR PAPER SIGNED BY DEBTOR UNLESS SUCH WAIVER IS EXPRESSED IN WRITING AND SIGNED BY
SECURED PARTY. A waiver on any one occasion shall not be construed as a bar to or waiver of any right or remedy on any future occasion.
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| | (g) | DEBTOR AND SECURED PARTY UNCONDITIONALLY WAIVE THEIR RIGHTS TO A JURY TRIAL OF ANY CLAIM OR CAUSE OF ACTION BASED UPON OR ARISING OUT OF THIS AGREEMENT, ANY OF THE OTHER DEBT
DOCUMENTS, ANY OF THE INDEBTEDNESS SECURED HEREBY, ANY DEALINGS BETWEEN DEBTOR AND SECURED PARTY RELATING TO THE SUBJECT MATTER OF THIS TRANSACTION OR ANY RELATED TRANSACTIONS. THIS WAIVER IS IRREVOCABLE. THIS WAIVER MAY NOT BE MODIFIED EITHER
ORALLY OR IN WRITING. THE WAIVER ALSO SHALL APPLY TO ANY SUBSEQUENT AMENDMENTS, RENEWALS, SUPPLEMENTS OR MODIFICATIONS TO THIS AGREEMENT, ANY OTHER DEBT DOCUMENTS, OR TO ANY OTHER DOCUMENTS OR AGREEMENTS RELATING TO THIS TRANSACTION OR ANY RELATED
TRANSACTION. THIS AGREEMENT MAY BE FILED AS A WRITTEN CONSENT TO A TRIAL BY THE COURT.
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|8. | MISCELLANEOUS.
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| | (a) | This Agreement, any Note and/or any of the other Debt Documents may be assigned in whole or in part, by Secured Party without notice to Debtor, and Debtor agrees not to assert
against any such assignee, or assignees assigns, any defense (other than the defense of payment), set-off, recoupment claim or counterclaim which Debtor has or may at any time have against Secured Party for any reason whatsoever.Debtor
agrees that if Debtor receives written notice of an assignment from Secured Party, Debtor will pay all amounts payable under any assigned Debt Documents to such assignee or as instructed by Secured Party. Debtor also agrees to confirm in writing
receipt of the notice of assignment as may be reasonably requested by Secured Party or assignee.
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| | (b) | All notices to be given in connection with this Agreement shall be in writing, shall be addressed to the parties at their respective addresses set forth in this Agreement (unless
and until a different address may be specified in a written notice to the other party), and shall be deemed given (i) on the date of receipt if delivered in hand or by facsimile transmission, (ii) on the next business day after being sent by express
mail, and (iii) on the fourth business day after being sent by regular, registered or certified mail. As used herein, the term business day shall mean and include any day other than Saturdays, Sundays, or other days on which commercial
banks in New York, New York are required or authorized to be closed.
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| | (c) | Secured Party may, with written consent either in original, electronic or facsimile form, correct patent errors and fill in all blanks in this Agreement or in any Collateral
Schedule consistent with the agreement of the parties.
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| | (d) | Time is of the essence of this Agreement. This Agreement shall be binding, jointly and severally, upon all parties described as the Debtor and their respective heirs,
executors, representatives, successors and assigns, and shall inure to the benefit of Secured Party, its successors and assigns.
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| | (e) | This Agreement and its Collateral Schedules constitute the entire agreement between the parties with respect to the subject matter of this Agreement and supersede all prior
understandings (whether written, verbal or implied) with respect to such subject matter. THIS AGREEMENT AND ITS COLLATERAL SCHEDULES SHALL NOT BE CHANGED OR TERMINATED ORALLY OR BY COURSE OF CONDUCT, BUT ONLY BY A WRITING SIGNED BY BOTH PARTIES.
Section headings contained in this Agreement have been included for convenience only, and shall not affect the construction or interpretation of this Agreement.
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| | (f) | This Agreement shall continue in full force and effect until all of the Indebtedness has been indefeasibly paid in full to Secured Party or its assignee. The surrender, upon payment
or otherwise, of any Note or any of the other documents evidencing any of the Indebtedness shall not affect the right of Secured Party to retain the Collateral for such other Indebtedness as may then exist or as it may be reasonably contemplated
will exist in the future. This Agreement shall automatically be reinstated if Secured Party is ever required to return or restore the payment of all or any portion of the Indebtedness (all as though such payment had never been made).
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| | (g) | DEBTOR AGREES THAT SECURED PARTY AND/OR ITS SUCCESSORS AND ASSIGNS SHALL HAVE THE OPTION BY WHICH STATE LAWS THIS AGREEMENT SHALL BE GOVERNED AND CONSTRUED: (A) THE LAWS OF THE
COMMONWEALTH OF VIRGINIA; OR (B) IF COLLATERAL HAS BEEN PLEDGED TO SECURE THE LIABILITIES, THEN BY THE LAWS OF THE STATE OR STATES WHERE THE COLLATERAL IS LOCATED, AT SECURED PARTYS OPTION. THIS CHOICE OF STATE LAWS IS EXCLUSIVE TO THE SECURED
PARTY. DEBTOR SHALL NOT HAVE ANY OPTION TO CHOOSE THE LAWS BY WHICH THIS AGREEMENT SHALL BE GOVERNED. DEBTOR
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---

ACKNOWLEDGES THAT THIS AGREEMENT IS BEING SIGNED BY THE SECURED PARTY IN PARTIAL CONSIDERATION OF SECURED
PARTYS RIGHT TO ENFORCE IN THE JURISDICTION STATED ABOVE. DEBTOR CONSENTS TO JURISDICTION IN THE COMMONWEALTH OF VIRGINIA OR THE STATE IN WHICH ANY COLLATERAL IS LOCATED AND VENUE IN ANY FEDERAL OR STATE COURT IN THE COMMONWEALTH OF VIRGINIA
OR THE STATE IN WHICH COLLATERAL IS LOCATED FOR SUCH PURPOSES AND WAIVES ANY AND ALL RIGHTS TO CONTEST SAID JURISDICTION AND VENUE AND ANY OBJECTION THAT SAID COUNTY IS NOT CONVENIENT. DEBTOR WAIVES ANY RIGHTS TO COMMENCE ANY ACTION AGAINST SECURED
PARTY IN ANY JURISDICTION EXCEPT VIRGINIA, OR IF SECURED PARTY CHOOSES TO LITIGATE IN A STATE WHERE COLLATERAL IS LOCTAED THEN IN SUCH COUNTY AND STATE. SECURED PARTY AND DEBTOR HEREBY EACH EXPRESSLY WAIVE ANY AND ALL RIGHTS TO A TRIAL BY JURY IN
ANY ACTION, PROCEEDING OR COUNTERCLAIM BROUGHT BY ANY OF THE PARTIES AGAINST ANY OTHER PARTY WITH RESPECT TO ANY MATTER WHATSOEVER RELATING TO, ARISING OUT OF OR IN ANY WAY CONNECTED WITH THE LOAN, THE DOCUMENTS AND/OR THE TRANSACTIONS WHICH ARE THE
SUBJECT OF THE DOCUMENTS.





IN WITNESS WHEREOF, Debtor and Secured Party, intending to be legally bound hereby, have duly executed this Agreement in one or more counterparts,
each of which shall be deemed to be an original, as of the day and year first aforesaid.





|                           |  |                            |  |        |  |                  
|-------------------------- |  | -------------------------- |  | ------ |  | -----------------
|SECURED PARTY:             |  | DEBTOR:                   
|                           | 
|Oxford Finance Corporation |  | Renovis, Inc.             
|                           |  |                            | 
|By:                        |  | /S/    MICHAEL ALTENBURGER |  | By:    |  | JOHN C. DOYLE    
|                           |  |                            |  |        |  |                  
|Name:                      |  |                            |  | Name:  |  |                  
|                           |  |                            |  |        |  |                  
|Title:                     |  | CFO                        |  | Title: |  | V.P. Finance, CFO
|                           |  |                            |  |        |  |                  



---

|Promissory Note | Schedule 01
|--------------- | -----------





PROMISSORY NOTE

To Master Security Agreement No. 4081047





---

(Date)





FOR VALUE RECEIVED, Renovis, Inc., a Delaware
corporation, located at the address stated below (Maker) promises, jointly and severally if more than one, to pay to the order of Oxford Finance Corporation or any subsequent holder hereof (each, a Payee)
at its office located at 133 N. Fairfax Street, Alexandria, VA 22314 or at such other place as Payee or the holder hereof may designate, the principal sum of Eight Hundred Eighty Two Thousand Eight Hundred Fifty Two AND 46/100 Dollars
($882,852.46), with interest on the unpaid principal balance, from the date hereof through and including the dates of payment, at a fixed interest rate of eight and eighty hundredths percent (8.80%) per annum, in forty eight (48) consecutive
monthly installments of principal and interest as follows:



|                     |  |            |  |  |  |  |  | 
|-------------------- |  | ---------- |  |  |  |  |  | 
|Periodic Installment |  | Amount     |  |  |  |  |  | 
|                     |  |            |  |  |  | 
|1-48                 |  | $21,726.12 |  |  |  |  |  | 



each (Periodic
Installment) and a final installment which shall be in the amount of the total outstanding principal and interest. The first Periodic Installment shall be due and payable on or around February 27, 2004 and the following Periodic
Installments and the final installment shall be due and payable on the same day of each succeeding April 1, 2004 (each, a Payment Date). Maker agrees to pay any initial partial month interest payment from the actual day of Note
disbursement to the first day of the succeeding month following Note disbursement. Such installments have been calculated on the basis of a 360-day year of twelve 30-day months. Each payment may, at the option of the Payee, be calculated and applied
on an assumption that such payment would be made on its due date.



The
acceptance by Payee of any payment which is less than payment in full of all amounts due and owing at such time shall not constitute a waiver of Payees right to receive payment in full at such time or at any prior or subsequent time.



The Maker hereby expressly authorizes the Payee to insert the date value is
actually given in the blank space on the face hereof and on all related documents pertaining hereto.



This Note may be secured by a security agreement, chattel mortgage, pledge agreement or like instrument (each of which is hereinafter called a Security Agreement and any Security Agreement, this Note
and any other document evidencing or securing this loan is hereinafter called a Debt Document).



Time is of the essence hereof. If any Periodic Installment or any other sum due under this Note or any Security Agreement is not received when due, the Maker agrees to
pay, in addition to the amount of each such Periodic Installment or other sum, a late payment charge of five percent (5%) of the amount of said installment or other sum, but not exceeding any lawful maximum. If (i) Maker fails to make payment of any
amount due hereunder; or (ii) Maker is in default under, or fails to perform under any term or condition contained in any Security Agreement, then the entire principal sum remaining unpaid, together with all accrued interest thereon and any other
sum payable under this Note or any Security Agreement, at the election of Payee, shall immediately become due and payable, with interest thereon at the lesser of twelve percent (12%) per annum or the highest rate not prohibited by applicable law
from the date of such accelerated maturity until paid (both before and after any judgment).



Notwithstanding anything to the contrary herein Maker may prepay in full any indebtedness hereunder upon five (5) days notice to the Payee. A principal prepayment shall be accompanied by payment of (i) all accrued and
unpaid interest and the outstanding principal balance of the Note and (ii) a premium of 5% of the principal prepaid if such prepayment shall occur in Year 1, a premium of 4% of the principal prepaid if such prepayment shall occur in Year 2 and a
premium of 3% of the principal prepaid if such prepayment shall occur in Year 3 and thereafter. Year 1 will mean the period consisting of the 1st through the 12th installments under this Note and subsequent years will refer to the subsequent twelve
monthly payment periods. A partial prepayment shall be applied to the principal components of the Periodic Installments in the inverse order of maturity.



The Maker and all sureties, endorsers, guarantors or any others (each such person, other than the Maker, an Obligor) who may at any time become liable
for the payment hereof jointly and severally consent hereby to any and all extensions of time, renewals, waivers or modifications of, and all substitutions or releases of, security or of any party primarily or secondarily liable on this Note or any
Security Agreement or any term and provision of either, which may be made, granted or consented to by Payee, and agree that suit may be brought and maintained against any one or more of them, at the election of Payee without joinder of any other as
a party thereto, and that Payee shall not be required first to foreclose, proceed against, or exhaust any security hereof in order to enforce payment of





Page 1 of 3



---

|Promissory Note | Schedule 01
|--------------- | -----------





this Note. The Maker and each Obligor hereby waives presentment, demand for payment, notice
of nonpayment, protest, notice of protest, notice of dishonor, and all other notices in connection herewith, as well as filing of suit (if permitted by law) and diligence in collecting this Note or enforcing any of the security hereof, and agrees to
pay (if and to the extent permitted by law) all reasonable expenses incurred in collection, including Payees actual and reasonable attorneys fees.



Maker and Payee intend to strictly comply with all applicable federal and Virginia laws, including applicable usury laws (or the usury laws of any jurisdiction whose
usury laws are deemed to apply to the Note or any other Debt Document despite the intention and desire of the parties to apply the usury laws of the Commonwealth of Virginia). Accordingly, the provisions of this paragraph shall govern and control
over every other provision of this Note or any other Debt Document which conflicts or is inconsistent with this Section, even if such provision declares that it controls. As used in this paragraph, the term interest includes the
aggregate of all charges, fees, benefits or other compensation which constitute interest under applicable law, provided that, to the maximum extent permitted by applicable law, (a) any non-principal payment shall be characterized as an
expense or as compensation for something other than the use, forbearance or detention of money and not as interest, and (b) all interest at any time contracted for, reserved, or charged shall be amortized, prorated, allocated and spread, in equal
parts during the full term of the obligations. In no event shall Maker or any other person be obligated to pay, or Payee have any right or privilege to reserve, receive or retain, (a) any interest in excess of the maximum amount of non-usurious
interest permitted under the laws of the Commonwealth of Virginia or the applicable laws (if any) of the United States or of any other state, or (b) total interest in excess of the amount which Payee could lawfully have contracted for, reserved,
received, retained or charged had the interest been calculated for the full term of the obligations. On each day, if any, that the interest rate (the Stated Rate) called for under this Note or any other Debt Document exceeds the
maximum non-usurious rate, the rate at which interest shall accrue shall automatically be fixed by operation of this sentence at the maximum non-usurious rate for that day. Thereafter, interest shall accrue at the Stated Rate unless and until the
Stated Rate again exceeds the maximum non-usurious rate, in which case, the provisions of the immediately preceding sentence shall again automatically operate to limit the interest accrual rate to the maximum non-usurious rate. The daily interest
rates to be used in calculating interest at the maximum non-usurious rate shall be determined by dividing the applicable maximum non-usurious rate by the number of days in the calendar year for which such calculation is being made. None of the terms
and provisions contained in this Note or in any other Debt Document which directly or indirectly relate to interest shall ever be construed without reference to this paragraph, or be construed to create a contract to pay for the use, forbearance or
detention of money at an interest rate in excess of the maximum non-usurious rate. If the term of any obligation is shortened by reason of acceleration of maturity as a result of any Event of Default or by any other cause, or by reason of any
required or permitted prepayment, and if for that (or any other) reason Payee at any time, including but not limited to, the stated maturity, is owed or receives (and/or has received) interest in excess of interest calculated at the maximum
non-usurious rate, then and in any such event all of any such excess interest shall be canceled automatically as of the date of such acceleration, prepayment or other event which produces the excess, and, if such excess interest has been paid to
Payee, it shall be credited pro tanto against the then-outstanding principal balance of Makers obligations to Payee, effective as of the date or dates when the event occurs which causes it to be excess interest, until such excess is
exhausted or all of such principal has been fully paid and satisfied, whichever occurs first, and any remaining balance of such excess shall be promptly refunded to its payor.



THE MAKER HEREBY UNCONDITIONALLY WAIVES ITS RIGHTS TO A JURY TRIAL OF ANY CLAIM OR CAUSE OF ACTION BASED UPON OR ARISING OUT OF, DIRECTLY
OR INDIRECTLY, THIS NOTE, ANY OF THE RELATED DOCUMENTS, ANY DEALINGS BETWEEN MAKER AND PAYEE RELATING TO THE SUBJECT MATTER OF THIS TRANSACTION OR ANY RELATED TRANSACTIONS. THE SCOPE OF THIS WAIVER IS INTENDED TO BE ALL ENCOMPASSING OF ANY AND ALL
DISPUTES THAT MAY BE FILED IN ANY COURT (INCLUDING, WITHOUT LIMITATION, CONTRACT CLAIMS, TORT CLAIMS, BREACH OF DUTY CLAIMS, AND ALL OTHER COMMON LAW AND STATUTORY CLAIMS.) THIS WAIVER IS IRREVOCABLE, MEANING THAT IT MAY NOT BE MODIFIED EITHER
ORALLY OR IN WRITING, AND THE WAIVER SHALL APPLY TO ANY SUBSEQUENT AMENDMENTS, RENEWALS, SUPPLEMENTS OR MODIFICATIONS TO THIS NOTE, ANY RELATED DOCUMENTS, OR TO ANY OTHER DOCUMENTS OR AGREEMENTS RELATING TO THIS TRANSACTION OR ANY RELATED
TRANSACTION. IN THE EVENT OF LITIGATION, THIS NOTE MAY BE FILED AS A WRITTEN CONSENT TO A TRIAL BY THE COURT.



The Note constitutes the entire agreement of the Maker and Payee with respect to the subject matter hereof and supercedes all prior understandings, agreements and
representations, express or implied.



No variation or modification of this
Note, or any waiver of any of its provisions or conditions, shall be valid unless in writing and signed by an authorized representative of Maker and Payee. Any such waiver, consent, modification or change shall be effective only in the specific
instance and for the specific purpose given.



Any provision in this Note, any
Security Agreement or any other Debt Document which is in conflict with any statute, law or applicable rule shall be deemed omitted, modified or altered to conform thereto.





Page 2 of 3



---

|Promissory Note | Schedule 01
|--------------- | -----------





Upon receipt of an affidavit of an officer of Payee as to the loss, theft, destruction or
mutilation of this Note or any Debt Document which is not of public record, and, in the case of any such loss, theft, destruction or mutilation, upon surrender and cancellation of such Note or other Debt Document, Maker will issue, in lieu thereof,
a replacement Note or other Debt Document in the principal amount then outstanding and otherwise of like tenor.



It is understood and agreed that this Note and all of the Debt Documents were negotiated and have been or will be delivered to Payee in the Commonwealth of Virginia,
which State the parties agree has a substantial relationship to the parties and to the underlying transactions embodied by this Note and the Debt Documents. Maker agrees to furnish to Payee at Payees office in Alexandria, VA, all further
instruments, certifications and documents to be furnished hereunder. The parties also agree that if collateral is pledged to secure the debt evidenced by this Note, that the state or states in which such collateral is located each have a substantial
relationship to the parties and to the underlying transaction embodied by this Note and the Debt Documents.



MAKER AGREES THAT THE PAYEE OF THIS NOTE SHALL HAVE THE OPTION BY WHICH STATE LAWS THIS NOTE SHALL BE GOVERNED AND CONSTRUED: (A) THE LAWS OF THE COMMONWEALTH OF
VIRGINIA; OR (B) IF COLLATERAL HAS BEEN PLEDGED TO SECURE THE DEBT EVIDENCED BY THIS NOTE, THEN BY THE LAWS OF THE STATE OR STATES WHERE THE COLLATERAL IS LOCATED, AT PAYEES OPTION. THIS CHOICE OF STATE LAWS IS EXCLUSIVE TO THE PAYEE OF THIS
NOTE. MAKER SHALL NOT HAVE ANY OPTION TO CHOOSE THE LAWS BY WHICH THIS NOTE SHALL BE GOVERNED. MAKER AND GUARANTORS HEREBY CONSENT TO THE EXERCISE OF JURISDICTION OVER IT BY ANY FEDERAL COURT SITTING IN VIRGINIA OR ANY VIRGINIA COURT SELECTED BY
PAYEE, FOR THE PURPOSES OF ANY AND ALL LEGAL PROCEEDINGS ARISING OUT OF OR RELATING TO THE NOTE, THE LOAN AGREEMENT AND ALL OTHER DOCUMENTS. MAKER IRREVOCABLY WAIVES, TO THE FULLEST EXTENT PERMITTED BY LAW, ANY OBJECTION WHICH IT MAY NOW OR
HEREAFTER HAVE TO THE LAYING OF VENUE OF ANY SUCH PROCEEDING BROUGHT IN ANY SUCH COURT, ANY CLAIM BASED ON THE CONSOLIDATION OF PROCEEDINGS IN SUCH COURTS IN WHICH PROPER VENUE MAY LIE IN DIVERGENT JURISDICTIONS, AND ANY CLAIM THAT ANY SUCH
PROCEEDING BROUGHT IN ANY SUCH COURT HAS BEEN BROUGHT IN AN INCONVENIENT FORUM. MAKER HEREBY IRREVOCABLY WAIVES, TO THE FULLEST EXTENT PERMITTED BY LAW, ANY AND ALL RIGHT TO TRIAL BY JURY IN ANY LEGAL PROCEEDING ARISING OUT OF OR RELATING TO THIS
NOTE, THE OTHER DOCUMENTS OR THE TRANSACTIONS CONTEMPLATED THEREBY.





|                    |  |                              |  |                              
|------------------- |  | ---------------------------- |  | -----------------------------
|                    |  | Renovis, Inc.               
|                    |  |                             
|/S/     JEFF FARROW |  | By:                          |  | /S/    JOHN C. DOYLE         
|                    |  |                              |  |                              
|(Witness)           |  |                              |  |                              
|                    |  | Name:                        |  |                              
|                    |  |                              |  |                              
|(Print name)        |  |                              |  |                              
|                    |  | Title:                       |  | V.P. Finance and CFO         
|                    |  |                              |  |                              
|(Address)           |  |                              |  |                              
|                    |  | Federal Tax ID #: 94-3353740
|                    |  |                             
|                    |  | Address:                     |  | Two Corporate Drive          
|                    |  |                              |  | South San Francisco, CA 94080



Page 3 of 3



---

|Promissory Note | Schedule 02
|--------------- | -----------





PROMISSORY NOTE

To Master Security Agreement No. 4081047







---

(Date)





FOR VALUE RECEIVED, Renovis, Inc., a Delaware corporation, located at the address stated below (Maker) promises, jointly and severally if more than one, to pay to the order of
Oxford Finance Corporation or any subsequent holder hereof (each, a Payee) at its office located at 133 N. Fairfax Street, Alexandria, VA 22314 or at such other place as Payee or the holder hereof may designate, the
principal sum of Six Hundred Eighty Thousand Six Hundred Forty One AND 05/100 Dollars ($680,641.05), with interest on the unpaid principal balance, from the date hereof through and including the dates of payment, at a fixed interest rate of
eight and eighty hundredths percent (8.80%) per annum, in forty two (42) consecutive monthly installments of principal and interest as follows:



|                     |  |            |  |  |  |  |  | 
|-------------------- |  | ---------- |  |  |  |  |  | 
|Periodic Installment |  | Amount     |  |  |  |  |  | 
|                     |  |            |  |  |  | 
|1-42                 |  | $18,750.30 |  |  |  |  |  | 



each (Periodic
Installment) and a final installment which shall be in the amount of the total outstanding principal and interest. The first Periodic Installment shall be due and payable on or around February 27, 2004 and the following Periodic
Installments and the final installment shall be due and payable on the same day of each succeeding April 1, 2004 (each, a Payment Date). Maker agrees to pay any initial partial month interest payment from the actual day of Note
disbursement to the first day of the succeeding month following Note disbursement. Such installments have been calculated on the basis of a 360-day year of twelve 30-day months. Each payment may, at the option of the Payee, be calculated and applied
on an assumption that such payment would be made on its due date.



The
acceptance by Payee of any payment which is less than payment in full of all amounts due and owing at such time shall not constitute a waiver of Payees right to receive payment in full at such time or at any prior or subsequent time.



The Maker hereby expressly authorizes the Payee to insert the date value is
actually given in the blank space on the face hereof and on all related documents pertaining hereto.



This Note may be secured by a security agreement, chattel mortgage, pledge agreement or like instrument (each of which is hereinafter called a Security Agreement and any Security Agreement, this Note
and any other document evidencing or securing this loan is hereinafter called a Debt Document).



Time is of the essence hereof. If any Periodic Installment or any other sum due under this Note or any Security Agreement is not received when due, the Maker agrees to
pay, in addition to the amount of each such Periodic Installment or other sum, a late payment charge of five percent (5%) of the amount of said installment or other sum, but not exceeding any lawful maximum. If (i) Maker fails to make payment of any
amount due hereunder; or (ii) Maker is in default under, or fails to perform under any term or condition contained in any Security Agreement, then the entire principal sum remaining unpaid, together with all accrued interest thereon and any other
sum payable under this Note or any Security Agreement, at the election of Payee, shall immediately become due and payable, with interest thereon at the lesser of twelve percent (12%) per annum or the highest rate not prohibited by applicable law
from the date of such accelerated maturity until paid (both before and after any judgment).



Notwithstanding anything to the contrary herein Maker may prepay in full any indebtedness hereunder upon five (5) days notice to the Payee. A principal prepayment shall be accompanied by payment of (i) all
accrued and unpaid interest and the outstanding principal balance of the Note and (ii) a premium of 5% of the principal prepaid if such prepayment shall occur in Year 1, a premium of 4% of the principal prepaid if such prepayment shall occur in Year
2 and a premium of 3% of the principal prepaid if such prepayment shall occur in Year 3 and thereafter. Year 1 will mean the period consisting of the 1st through the 12th installments under this Note and subsequent years will refer to the subsequent
twelve monthly payment periods. A partial prepayment shall be applied to the principal components of the Periodic Installments in the inverse order of maturity.



The Maker and all sureties, endorsers, guarantors or any others (each such person, other than the Maker, an Obligor) who may at any time become
liable for the payment hereof jointly and severally consent hereby to any and all extensions of time, renewals, waivers or modifications of, and all substitutions or releases of, security or of any party primarily or secondarily liable on this Note
or any Security Agreement or any term and provision of either, which may be made, granted or consented to by Payee, and agree that suit may be brought and maintained against any one or more of them, at the election of Payee without joinder of any
other as a party thereto, and that Payee shall not be required first to foreclose, proceed against, or exhaust any security hereof in order to enforce payment of





Page 1 of 3



---

|Promissory Note | Schedule 02
|--------------- | -----------





this Note. The Maker and each Obligor hereby waives presentment, demand for payment, notice
of nonpayment, protest, notice of protest, notice of dishonor, and all other notices in connection herewith, as well as filing of suit (if permitted by law) and diligence in collecting this Note or enforcing any of the security hereof, and agrees to
pay (if and to the extent permitted by law) all reasonable expenses incurred in collection, including Payees actual and reasonable attorneys fees.



Maker and Payee intend to strictly comply with all applicable federal and Virginia laws, including applicable usury laws (or the usury laws of any jurisdiction whose
usury laws are deemed to apply to the Note or any other Debt Document despite the intention and desire of the parties to apply the usury laws of the Commonwealth of Virginia). Accordingly, the provisions of this paragraph shall govern and control
over every other provision of this Note or any other Debt Document which conflicts or is inconsistent with this Section, even if such provision declares that it controls. As used in this paragraph, the term interest includes the
aggregate of all charges, fees, benefits or other compensation which constitute interest under applicable law, provided that, to the maximum extent permitted by applicable law, (a) any non-principal payment shall be characterized as an
expense or as compensation for something other than the use, forbearance or detention of money and not as interest, and (b) all interest at any time contracted for, reserved, or charged shall be amortized, prorated, allocated and spread, in equal
parts during the full term of the obligations. In no event shall Maker or any other person be obligated to pay, or Payee have any right or privilege to reserve, receive or retain, (a) any interest in excess of the maximum amount of non-usurious
interest permitted under the laws of the Commonwealth of Virginia or the applicable laws (if any) of the United States or of any other state, or (b) total interest in excess of the amount which Payee could lawfully have contracted for, reserved,
received, retained or charged had the interest been calculated for the full term of the obligations. On each day, if any, that the interest rate (the Stated Rate) called for under this Note or any other Debt Document exceeds the
maximum non-usurious rate, the rate at which interest shall accrue shall automatically be fixed by operation of this sentence at the maximum non-usurious rate for that day. Thereafter, interest shall accrue at the Stated Rate unless and until the
Stated Rate again exceeds the maximum non-usurious rate, in which case, the provisions of the immediately preceding sentence shall again automatically operate to limit the interest accrual rate to the maximum non-usurious rate. The daily interest
rates to be used in calculating interest at the maximum non-usurious rate shall be determined by dividing the applicable maximum non-usurious rate by the number of days in the calendar year for which such calculation is being made. None of the terms
and provisions contained in this Note or in any other Debt Document which directly or indirectly relate to interest shall ever be construed without reference to this paragraph, or be construed to create a contract to pay for the use, forbearance or
detention of money at an interest rate in excess of the maximum non-usurious rate. If the term of any obligation is shortened by reason of acceleration of maturity as a result of any Event of Default or by any other cause, or by reason of any
required or permitted prepayment, and if for that (or any other) reason Payee at any time, including but not limited to, the stated maturity, is owed or receives (and/or has received) interest in excess of interest calculated at the maximum
non-usurious rate, then and in any such event all of any such excess interest shall be canceled automatically as of the date of such acceleration, prepayment or other event which produces the excess, and, if such excess interest has been paid to
Payee, it shall be credited pro tanto against the then-outstanding principal balance of Makers obligations to Payee, effective as of the date or dates when the event occurs which causes it to be excess interest, until such excess is
exhausted or all of such principal has been fully paid and satisfied, whichever occurs first, and any remaining balance of such excess shall be promptly refunded to its payor.



THE MAKER HEREBY UNCONDITIONALLY WAIVES ITS RIGHTS TO A JURY TRIAL OF ANY CLAIM OR CAUSE OF ACTION BASED UPON OR ARISING OUT OF, DIRECTLY
OR INDIRECTLY, THIS NOTE, ANY OF THE RELATED DOCUMENTS, ANY DEALINGS BETWEEN MAKER AND PAYEE RELATING TO THE SUBJECT MATTER OF THIS TRANSACTION OR ANY RELATED TRANSACTIONS. THE SCOPE OF THIS WAIVER IS INTENDED TO BE ALL ENCOMPASSING OF ANY AND ALL
DISPUTES THAT MAY BE FILED IN ANY COURT (INCLUDING, WITHOUT LIMITATION, CONTRACT CLAIMS, TORT CLAIMS, BREACH OF DUTY CLAIMS, AND ALL OTHER COMMON LAW AND STATUTORY CLAIMS.) THIS WAIVER IS IRREVOCABLE, MEANING THAT IT MAY NOT BE MODIFIED EITHER
ORALLY OR IN WRITING, AND THE WAIVER SHALL APPLY TO ANY SUBSEQUENT AMENDMENTS, RENEWALS, SUPPLEMENTS OR MODIFICATIONS TO THIS NOTE, ANY RELATED DOCUMENTS, OR TO ANY OTHER DOCUMENTS OR AGREEMENTS RELATING TO THIS TRANSACTION OR ANY RELATED
TRANSACTION. IN THE EVENT OF LITIGATION, THIS NOTE MAY BE FILED AS A WRITTEN CONSENT TO A TRIAL BY THE COURT.



The Note constitutes the entire agreement of the Maker and Payee with respect to the subject matter hereof and supercedes all prior understandings, agreements and
representations, express or implied.



No variation or modification of this
Note, or any waiver of any of its provisions or conditions, shall be valid unless in writing and signed by an authorized representative of Maker and Payee. Any such waiver, consent, modification or change shall be effective only in the specific
instance and for the specific purpose given.



Any provision in this Note, any
Security Agreement or any other Debt Document which is in conflict with any statute, law or applicable rule shall be deemed omitted, modified or altered to conform thereto.





Page 2 of 3



---

|Promissory Note | Schedule 02
|--------------- | -----------





Upon receipt of an affidavit of an officer of Payee as to the loss, theft, destruction or
mutilation of this Note or any Debt Document which is not of public record, and, in the case of any such loss, theft, destruction or mutilation, upon surrender and cancellation of such Note or other Debt Document, Maker will issue, in lieu thereof,
a replacement Note or other Debt Document in the principal amount then outstanding and otherwise of like tenor.



It is understood and agreed that this Note and all of the Debt Documents were negotiated and have been or will be delivered to Payee in the Commonwealth of Virginia,
which State the parties agree has a substantial relationship to the parties and to the underlying transactions embodied by this Note and the Debt Documents. Maker agrees to furnish to Payee at Payees office in Alexandria, VA, all further
instruments, certifications and documents to be furnished hereunder. The parties also agree that if collateral is pledged to secure the debt evidenced by this Note, that the state or states in which such collateral is located each have a substantial
relationship to the parties and to the underlying transaction embodied by this Note and the Debt Documents.



MAKER AGREES THAT THE PAYEE OF THIS NOTE SHALL HAVE THE OPTION BY WHICH STATE LAWS THIS NOTE SHALL BE GOVERNED AND CONSTRUED: (A) THE LAWS OF THE COMMONWEALTH OF
VIRGINIA; OR (B) IF COLLATERAL HAS BEEN PLEDGED TO SECURE THE DEBT EVIDENCED BY THIS NOTE, THEN BY THE LAWS OF THE STATE OR STATES WHERE THE COLLATERAL IS LOCATED, AT PAYEES OPTION. THIS CHOICE OF STATE LAWS IS EXCLUSIVE TO THE PAYEE OF THIS
NOTE. MAKER SHALL NOT HAVE ANY OPTION TO CHOOSE THE LAWS BY WHICH THIS NOTE SHALL BE GOVERNED. MAKER AND GUARANTORS HEREBY CONSENT TO THE EXERCISE OF JURISDICTION OVER IT BY ANY FEDERAL COURT SITTING IN VIRGINIA OR ANY VIRGINIA COURT SELECTED BY
PAYEE, FOR THE PURPOSES OF ANY AND ALL LEGAL PROCEEDINGS ARISING OUT OF OR RELATING TO THE NOTE, THE LOAN AGREEMENT AND ALL OTHER DOCUMENTS. MAKER IRREVOCABLY WAIVES, TO THE FULLEST EXTENT PERMITTED BY LAW, ANY OBJECTION WHICH IT MAY NOW OR
HEREAFTER HAVE TO THE LAYING OF VENUE OF ANY SUCH PROCEEDING BROUGHT IN ANY SUCH COURT, ANY CLAIM BASED ON THE CONSOLIDATION OF PROCEEDINGS IN SUCH COURTS IN WHICH PROPER VENUE MAY LIE IN DIVERGENT JURISDICTIONS, AND ANY CLAIM THAT ANY SUCH
PROCEEDING BROUGHT IN ANY SUCH COURT HAS BEEN BROUGHT IN AN INCONVENIENT FORUM. MAKER HEREBY IRREVOCABLY WAIVES, TO THE FULLEST EXTENT PERMITTED BY LAW, ANY AND ALL RIGHT TO TRIAL BY JURY IN ANY LEGAL PROCEEDING ARISING OUT OF OR RELATING TO THIS
NOTE, THE OTHER DOCUMENTS OR THE TRANSACTIONS CONTEMPLATED THEREBY.





|                    |  |                              |  |                              
|------------------- |  | ---------------------------- |  | -----------------------------
|                    |  | Renovis, Inc.               
|                    |  |                             
|/S/     JEFF FARROW |  | By:                          |  | /S/    JOHN C. DOYLE         
|                    |  |                              |  |                              
|(Witness)           |  |                              |  |                              
|                    |  | Name:                        |  |                              
|                    |  |                              |  |                              
|(Print name)        |  |                              |  |                              
|                    |  | Title:                       |  | V.P. Finance and CFO         
|                    |  |                              |  |                              
|(Address)           |  |                              |  |                              
|                    |  | Federal Tax ID #: 94-3353740
|                    |  |                             
|                    |  | Address:                     |  | Two Corporate Drive          
|                    |  |                              |  | South San Francisco, CA 94080



Page 3 of 3