Exhibit 10.1

    

    

    REGISTRATION RIGHTS AGREEMENT

    

    

    dated as of [●], 2021

    

    

    among

    

    

    GH RESEARCH PLC

    

    

    and

    

    

    THE HOLDERS NAMED HEREIN

    

    

    TABLE OF CONTENTS

    

    

    	 	 	
            Page

          
	
            Section 1.

          	
            Defined Terms; Rules of Construction

          	
            1

          
	 	
            1.1   Defined Terms

          	
            1

          
	 	
            1.2   Rules of Construction

          	
            8

          
	
            Section 2.

          	
            Demand Registration

          	
            8

          
	
            Section 3.

          	
            Registrations on Form S-3 or F-3

          	
            10

          
	
            Section 4.

          	
            Piggyback Registration

          	
            11

          
	
            Section 5.

          	
            Rule 144 Reporting

          	
            12

          
	
            Section 6.

          	
            Preparation and Filing

          	
            13

          
	
            Section 7.

          	
            Expenses

          	
            15

          
	
            Section 8.

          	
            Indemnification

          	
            15

          
	
            Section 9.

          	
            Underwriting Agreement

          	
            17

          
	
            Section 10.

          	
            Suspension

          	
            18

          
	
            Section 11.

          	
            Information by Holder

          	
            18

          
	
            Section 12.

          	
            Termination

          	
            19

          
	
            Section 13.

          	
            Limitation On Other Registration Rights

          	
            19

          
	
            Section 14.

          	
            Miscellaneous

          	
            19

          
	 	
            14.1  Notices

          	
            19

          
	 	
            14.2  Assignment

          	
            19

          
	 	
            14.3  Entire Agreement

          	
            20

          
	 	
            14.4  Modifications, Amendments and Waivers

          	
            20

          
	 	
            14.5  Counterparts

          	
            20

          
	 	
            14.6  Governing Law

          	
            20

          
	 	
            14.7  Submission to Jurisdiction; Waiver of Jury Trial

          	
            20

          
	 	
            14.8  Severability

          	
            21

          
	 	
            14.9  No Third Party Beneficiary

          	
            21

          
	 	
            14.10  Non-Recourse

          	
            21

          
	 	
            14.11  Specific Performance

          	
            22

          
	 	
            14.12  Business Days

          	
            22

          
	 	
            14.13  Electronic Execution

          	
            22

          
	 	
            14.14  Captions

          	
            22

          


    

    

    

    

    This Registration Rights Agreement dated as of [●], 2021 (this “Agreement”), is by and among GH Research PLC (the “Company”)

      and the Holders listed in Schedule A hereto. Capitalized terms used but not defined elsewhere herein have the meanings assigned to them in Section 1.1.

    

    

    WHEREAS, the Holders are currently party to that certain Shareholders’ Agreement relating to GH Research Ireland Limited, a wholly-owned subsidiary of the Company dated April 12, 2021 (the “Shareholders’ Agreement”) that provides for, among other things, the Company and the Holders to enter into a registration rights agreement, effective no later than the closing of an IPO (as defined in the
      Shareholders’ Agreement);

    

    

    
      

      
        


      

    

    
    

    

    WHEREAS, the Company will adopt a new Constitution (as defined below) in connection with an IPO; and

    

    

    WHEREAS, as part of the arrangements to enable the Company to consummate an IPO, the Holders and the Company desire to enter into this Agreement to set forth the registration rights of the
      Holders with respect to any Registrable Securities held by them.

    

    

    WHEREAS, the Holders acknowledge that the registration rights of the Holders shall not apply to the IPO.

    

    

    NOW, THEREFORE, in consideration of the premises and the mutual covenants and agreements contained herein, and for other good and valuable consideration, the receipt and sufficiency of which is
      hereby acknowledged, the parties agree as follows:

    

    

    Section 1. DEFINED TERMS; RULES OF CONSTRUCTION.

    

    

    1.1 DEFINED TERMS. Capitalized terms used and not otherwise defined in this Agreement have the meanings ascribed to them below:

    

    

    “Affiliate” means, in relation to one Person, any Person that is, directly or indirectly, (i) Controlled by, (ii) Controlling, or (iii) under common
      Control with such other Person, as of the date on which, or at any time during the period in which, such affiliate status is determined.

    

    

    “Agreement” has the meaning set forth in the preamble hereof.

    

    

    “Asset Sale” means the disposal (in one transaction or a series of connected transactions) by the Company of all or substantially all of its undertaking
      and assets (which shall include, without limitation, the grant by the Company of an exclusive license over all or substantially all of the commercially valuable intellectual property of the Company not entered into in the ordinary course of
      business);

    

    

    “Board” means the board of directors of the Company as constituted from time to time.

    

    

    “Business Day” means any day other than Saturday, Sunday or a day on which commercial banks are required or authorized by law to remain closed in Dublin,
      Ireland or New York, New York.

    

    

    “Company” has the meaning set forth in the preamble hereof.

    

    

    “Company Notice” has the meaning set forth in Section 2(a) hereof.

    

    

    “Constitution” means the constitution of the Company as amended or superseded from time to time.

    

    

    “Control” shall have the meaning ascribed in Rule 405 of the Securities Act. The terms “Controlled” and “Controlling” shall be construed accordingly with
      this definition.

    

    

    “Deemed Liquidation Event” means a merger or consolidation of the Company involving the cessation of the Company’s existence as an independent body
      corporate (other than a merger or consolidation in which the Company’s shareholders immediately prior to completion of the merger or consolidation continue to be entitled to exercise a majority of the voting rights attaching to the shares or
      securities of the merged or consolidated entity immediately following completion of the merger or consolidation and in substantially the same proportions between them as they were entitled to exercise those voting rights in the share capital of the
      Company immediately prior to such merger or consolidation).

    

    

    “Delay/Suspension Period” has the meaning set forth in Section 10 hereof.

    

    

    “Demand Notice” has the meaning set forth in Section 2(a) hereof.

    

    

    “Demand Registration” has the meaning set forth in Section 2(a) hereof.

    

    

    
      

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    “Eligible Holders” has the meaning set forth in Section 2(a) hereof.

    

    

    “Exchange Act” means the Securities Exchange Act of 1934, as amended.

    

    

    “F-3” means such form under the Securities Act as in effect on the date of this Agreement or any successor registration form under the Securities Act
      subsequently adopted by the SEC that permits inclusion or incorporation of substantial information by reference to other documents filed by the Company with the SEC in a similar or comparable manner.

    

    

    “Family Trust” means in relation to an individual, a trust (whether arising under a settlement, declaration of trust or other instrument by whomsoever or
      wheresoever made or under a testamentary disposition or on an intestacy) under which no immediate beneficial interest in any of the Ordinary Shares in question is for the time being vested in any person other than that individual and/or Privileged
      Relations of that individual; and so that for this purpose a person shall be considered to be beneficially interested in a share if such share or the income therefrom is or may become liable to be transferred or paid or applied or appointed to or for
      the benefit of such person or any voting or other rights attaching thereto are or may become liable to be exercisable by or as directed by such person pursuant to the terms of the relevant trusts or in consequence of an exercise of a power or
      discretion conferred thereby on any person or persons.

    

    

    “FINRA” means the Financial Industry Regulatory Authority, Inc.

    

    

    “Governmental Authority” means (i) the federal government, any state or municipal government or other national or foreign political subdivision with
      jurisdiction over the applicable Person; (ii) an executive, regulatory, legislative, judicial or administrative government entity or authority with jurisdiction over the applicable Person, whether national or foreign, which includes, with respect to
      items (i) and (ii) above, their respective bodies, autonomous government entities, self-regulatory entities, divisions, departments, boards, representation offices, agencies or commissions, including the SEC; (iii) a single court, tribunal or
      judicial, administrative or arbitration body; or (iv) any stock exchange or organized over-the-counter market to which the applicable Person is subject.

    

    

    “Holder” shall mean the Investors or any of their Affiliates, so long as such Person holds any Registrable Securities and any Person owning Registrable
      Securities who is a Permitted Transferee of rights under Section 14.2.

    

    

    “Holder Majority” means, (i) with respect to a particular Registration Statement, Holder(s) holding more than 70% of the Registrable Securities then-held
      by Holder(s) who are participating in such Registration Statement and (ii) for all other purposes, Holder(s) holding more than 70% of the Registrable Securities then-held by Holder(s);.

    

    

    “Initiating Holder” has the meaning set forth in Section 2(a) hereof.

    

    

    “Insolvency Proceedings” means any insolvency related proceedings, whether in or out of court, including proceedings or steps leading to any form of
      bankruptcy, liquidation, administration, receivership, arrangement or scheme with creditors, moratorium, stay or limitation of creditors’ rights, interim or provisional supervision by a court or court appointee, winding up or striking off, or any
      distress, execution, commercial rent arrears recovery or other process levied or exercised, or any event similar to any such events in any jurisdiction outside England and Wales.

    

    

     “Investors” means each Party listed in Schedule A hereto, and any other person who becomes a party to the Shareholders’ Agreement as an “Investor” by
      signing a Deed of Adherence in accordance with clause 7.7 of the Shareholders’ Agreement and is named in that Deed of Adherence as an “Investor”.

    

    

    “IPO” means the Company’s firm commitment underwritten initial public offering of Ordinary Shares representing Ordinary Shares of the Company under the
      Securities Act, consummated on or about the date hereof, for listing on Nasdaq.

    

    

    
      

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    “Material Adverse Change” means (1) in the opinion of a Holder Majority, there has been a material adverse change in the position or prospects of the
      Company; or (2) the Company has entered into any Insolvency Proceedings.

    

    

    “Material Transaction” means any material transaction in which the Company or any of its subsidiaries proposes to engage or is engaged, including a
      material purchase or sale of assets or securities, financing, merger, consolidation, reorganization, tender offer or any other material transaction that would require disclosure pursuant to the Exchange Act, and with respect to which the board of
      directors of the Company reasonably has determined in good faith that compliance with this Agreement may reasonably be expected to either materially interfere with the Company’s or such subsidiary’s ability to consummate such transaction in a timely
      fashion or require the Company to disclose material, non-public information prior to such time as it would otherwise be required to be disclosed.

    

    

    “Ordinary Shares” refer to the ordinary shares in the issued share capital of the Company following the closing of the IPO.

    

    

    “Original Shareholder” means in relation to a Permitted Transfer of Ordinary Shares, the transferor or (in the case of a series of Permitted Transfers)
      the first transferor in the series.

    

    

    “Other Securities” means with respect to a particular registration statement, any of the Ordinary Shares or Ordinary Shares that are to be included in
      such registration statement that are not Primary Securities or Registrable Securities.

    

    

    “Permitted Transfers” means an Affiliate, Family Trust or Privileged Relation of the relevant transferor.

    

    

    “Person” means an individual, company (whether incorporated or not), general or limited partnership, association, foundation, condominium, fund,
      consortia, joint venture, entity, trust, international or multilateral organization or other public, private or semi-public entity and any Governmental Authority as well as the successors thereof.

    

    

    “Primary Securities” means, with respect to a particular registration statement, any of the Ordinary Shares or Ordinary Shares, which may be sold by the
      Company in a registered offering pursuant to such registration statement.

    

    

    “Privileged Relation” means in relation to an individual, a spouse, civil partner, child or grandchild (including step or adopted children and their
      issue) of that individual.

    

    

    “Prospectus” means the prospectus included in a Registration Statement filed with the SEC, including any prospectus subject to completion, and any such
      prospectus as amended or supplemented by any prospectus supplement with respect to the terms of the offering of any portion of the Registrable Securities and, in each case, by all other amendments and supplements to such prospectus, including
      post-effective amendments, and in each case including all material incorporated by reference therein.

    

    

    “Registrable Securities” means, at any time, and with respect to any Holder, all Ordinary Shares without designation issued or issuable upon conversion
      or exchange of the series A preferred shares and the series B preferred shares of the Company previously held by such Holder; provided that “Registrable Securities” shall exclude (i) any Ordinary Shares without designation sold by a person to
      the public pursuant either to an effective registration statement under the Securities Act or Rule 144 under the Securities Act, and (ii) any Ordinary Shares without designation sold by a person in a transaction in which the applicable rights under
      clause 7 of the Shareholders’ Agreement are not assigned to a Permitted Transferee in accordance with the terms of this Agreement or for which registration rights have terminated.

    

    

    “Registration” means a registration with the SEC of the offer and sale to the public of Ordinary Shares under a Registration Statement. The terms “Register,” “Registered” and “Registering” shall have a correlative meaning.

    

    

    “Registration Statement” means any registration statement of the Company that registers any of the Registrable Securities under the Securities Act, and
      all amendments and supplements to any such Registration Statement, including post-effective amendments, in each case including the Prospectus contained therein, all exhibits thereto and all material incorporated by reference therein.

    

    

    
      

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    “Rule 144” means Rule 144 promulgated under the Securities Act or any successor rule thereto.

    

    

    “S-3” means such form under the Securities Act as in effect on the date of this Agreement or any successor registration form under the Securities Act
      subsequently adopted by the SEC that permits inclusion or incorporation of substantial information by reference to other documents filed by the Company with the SEC in a similar or comparable manner.

    

    

    “SEC” means the United States Securities and Exchange Commission.

    

    

    “Securities Act” the United States Securities Act of 1933, as amended.

    

    

    “Shareholders Agreement” means the Shareholders Agreement dated as of April 12, 2021, among the Company and the Holders.

    

    

    “Subsidiary”, “Subsidiary Undertaking” and “Parent Undertaking” have the
      respective meanings set out in sections 1159 and 1162 of the Act;

    

    

    “Holders’ Counsel” has the meaning set forth in Section 6(a)(ii) hereof.

    

    

    “Takedown Notice” has the meaning set forth in Section 3(a) hereof.

    

    

    “Transaction Documents” means this Agreement and the other agreements, instruments and documents contemplated hereby and thereby, including each exhibit
      hereto and thereto.

    

    

    “Trustees” in relation to a Holder means the trustee or the trustees of a Family Trust.

    

    

    “Underwritten Offering” means a Registration in which securities of the Company (including as may be represented by Ordinary Shares) are sold to an
      underwriter or underwriters on a firm commitment basis for reoffering to the public in a widely distributed offering.

    

    

    “$” means the lawful currency of the United States of America.

    

    

    1.2 RULES OF CONSTRUCTION. The term “this Agreement” means this registration rights agreement together with all schedules and exhibits hereto, as
      the same may from time to time be amended, modified, supplemented or restated in accordance with the terms hereof. The use in this Agreement of the term “including” means “including, without limitation.” The words “herein,” “hereof,” “hereunder” and
      other words of similar import refer to this Agreement as a whole, including the schedules and exhibits, as the same may from time to time be amended, modified, supplemented or restated, and not to any particular section, subsection, paragraph,
      subparagraph or clause contained in this Agreement. All references to sections, schedules and exhibits mean the sections of this Agreement and the schedules and exhibits attached to this Agreement, except where otherwise stated. The title of and the
      section and paragraph headings in this Agreement are for convenience of reference only and shall not govern or affect the interpretation of any of the terms or provisions of this Agreement. Where specific language is used to clarify by example a
      general statement contained herein, such specific language shall not be deemed to modify, limit or restrict in any manner the construction of the general statement to which it relates. Unless expressly provided otherwise, the measure of a period of
      one month or year for purposes of this Agreement shall be that date of the following month or year corresponding to the starting date, provided that if no corresponding date exists, the measure shall be that date of the following month or
      year corresponding to the next day following the starting date. For example, one month following February 18 is March 18, and one month following March 31 is May 1.

    

    

    Section 2. DEMAND REGISTRATION.

    

    

    (a) At any time after one hundred eighty (180) days following the consummation of the IPO, for so long as any Registrable Securities are then outstanding, a Holder or Holders holding in the
      aggregate at least ten percent (10%) of the Registrable Securities then outstanding shall have the right to request that the Company file and cause to become effective a Registration Statement on Form F-1 with the SEC on the appropriate registration
      form for all or part of the Registrable Securities held by such Holder(s) once such Holder(s) are no longer subject to the lock-up applicable to them entered into in connection with the IPO (which may be due to the expiration or waiver of such
      lock-up with respect to such Registrable Securities) (a “Demand Notice”) by delivering a written request to the Company specifying the number of Registrable Securities such Holder(s) wish to Register and the
      intended method of distribution thereof (a “Demand Registration” and the Holder(s) submitting such Demand Registration, the “Initiating Holder” or “Initiating Holders”, collectively). The Company shall (i) within twenty (20) days of the receipt of such request, give written notice of such Demand Registration (the “Company
        Notice”) to all Holders other than the Initiating Holder(s) (the “Eligible Holders”), (ii) as soon as practicable, and in any event within forty-five (45) days of receipt of such request, file a
      Registration Statement in respect of such Demand Registration, provided that all necessary documents for the registration can be obtained and prepared within such 45-day period; and (iii) use its reasonable best efforts to cause such
      Registration Statement to become effective as soon as practicable thereafter. The Company shall include in such Registration all Registrable Securities that the Eligible Holders request to be included within the twenty (20) days following their
      receipt of the Company Notice. If the method of distributing the offering is an Underwritten Offering, the Company shall include such information in the Company Notice, and the managing underwriter for such offering will be designated by the Board
      and shall reasonably acceptable to a majority in interest of the Initiating Holders.

    

    

    
      

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    (b) The Company shall not be obligated to file and use its reasonable best efforts to cause to become effective: (i) more than one Registration Statement initiated pursuant to Section 2(a);
      (ii) any Registration Statement pursuant to Section 2(a) (A) if the Company believes, in good faith, that it will file and cause to be effective a registration statement with respect to Primary Securities (other than on Form F-4 or Form S-8
      promulgated under the Securities Act or any successor forms thereto) within 60 days of such a demand or (B) if a registration statement with respect to Primary Securities (other than on Form F-4 or Form S-8 promulgated under the Securities Act or any
      successor forms thereto) has been declared effective in the prior 180 days; provided that in connection with any such registration statement that has not been declared effective, the Company is in good faith using commercially reasonable
      efforts to cause such registration statement to become effective. The Registrable Securities requested to be Registered pursuant to Section 2(a) (including, for the avoidance of doubt, the Registrable Securities of Eligible Holders requested to be
      registered) must represent an aggregate price to the public of Registrable Securities that is reasonably expected to equal at least $50,000,000; or (iii) a Registration Statement initiated pursuant to Section 2(a) if the Holders propose to dispose of
      Registrable Securities that may be immediately registered on Form F-3 pursuant to a request made pursuant to Section 3(a).

    

    

    (c) With respect to any registration pursuant to Section 2(a), the Company may include in such registration any Primary Securities or Other Securities; provided, however, that
      if the managing underwriter or underwriters formally advise(s) the Company in writing and with sufficient explanation that the inclusion of all Registrable Securities, Primary Securities and Other Securities proposed to be included in such
      registration would interfere with the successful marketing (including, but not limited to, pricing) of all such securities, then the number of Registrable Securities, Primary Securities and Other Securities proposed to be included in such
      registration shall be included in the following order:

    

    

    (i) first, the Registrable Securities held by the Holders requesting that their Registrable Securities be included in such registration pursuant to Section 2(a), pro rata
      based upon the number of Registrable Securities owned by each such Holder at the time of such registration; provided, however, that the number of Registrable Securities held by the Holders to be included in such underwriting shall not
      be reduced unless all Primary Securities and Other Securities are first entirely excluded from the underwriting, provided that for purposes of this Subsection 2(c) concerning apportionment, any selling Holder and all Affiliates of that selling Holder
      shall be deemed to be a single “selling Holder,” and any pro rata reduction with respect to such “selling Holder” shall be based upon the aggregate number of Registrable Securities owned by all persons included in such “selling Holder,” as defined in
      this sentence;

    

    

    (ii) second, the Primary Securities; and

    

    

    (iii) third, the Other Securities.

    

    

    To facilitate the allocation of Ordinary Shares in accordance with the above provisions, the Company or the underwriters may round the number of Shares allocated to any
      Holder to the nearest one hundred (100) shares.

    

    

    
      

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    (d) A requested registration under this Section 2 may be rescinded at any time prior to such registration being declared effective by the SEC by written notice to the Company from those Holders
      who initiated the request, at their discretion; provided, however, that such rescinded registration shall not count as a registration initiated pursuant to this Section 2 for purposes of Section 2(b)(i) above if (i) such request to
      rescind the registration is during a period the Company has deferred taking action pursuant to Section 2(b)(ii) above or Section 10 below or (ii) if the Company shall have been reimbursed (pro rata by the Holders requesting registration or in
      such other proportion as they may agree) for all reasonable and documented out-of-pocket expenses incurred by the Company in connection with such rescinded registration; provided, further, however, that if, at the time of such
      rescission, the Holders who initiated the request shall have learned of an event that is, or is reasonably likely to result in, a Material Adverse Change from that known to such Holders at the time of their request and have withdrawn the request with
      reasonable promptness after learning of such information then the Holders shall not be required to reimburse the Company for any out-of-pocket expenses incurred by the Company in connection with such rescinded registration and such rescinded
      registration shall not count as a registration initiated pursuant to this Section 2 for purposes of clause (i) of subsection (b).

    

    

    (e) The Company shall be deemed to have effected a Registration for purposes of Section 2(a) only if the applicable Registration Statement (i) is declared effective by the SEC or becomes
      effective upon filing with the SEC, or (ii) is withdrawn at the request of the requesting Holders (other than as a result of a Material Adverse Change to the Company).

    

    

    (f) In the event that the Company intends to effect a Registration for purposes of Section 2(a) by means of an Underwritten Offering, no Holder may include Registrable Securities in such
      Registration unless such Holder, subject to the limitations set forth in Section 9, (i) agrees to sell its Registrable Securities on the basis provided in the applicable underwriting arrangements; (ii) completes and executes all questionnaires,
      powers of attorney, indemnities, underwriting agreements and other documents reasonably required and in customary form under the terms of such underwriting arrangements and (iii) cooperates with the Company’s reasonable and customary requests in
      connection with such Registration (it being understood that the Company’s failure to perform its obligations hereunder, which failure is caused by such Holder’s failure to cooperate, will not constitute a breach by the Company of this Agreement).

    

    

    (f) For purposes of Section 2, a registration shall not be counted as “effected” if, as a result of an exercise of the underwriter’s cutback provisions in Section 2(c), fewer than fifty percent
      (50%) of the total number of Registrable Securities that Holders have requested to be included in such registration statement are actually included.

    

    

    Section 3. REGISTRATIONS ON FORM S-3 OR F-3.

    

    

    (a) Subject to Section 3(b), at any time after the date hereof when the Company is eligible to Register the applicable Registrable Securities on Form S-3 or Form F-3 (or a successor form), a
      Holder or Holders holding in the aggregate at least twenty percent (20%) of the Registrable Securities then outstanding is entitled to request a Demand Registration pursuant to which the Company shall, as soon as practicable and in any event within
      forty-five (45) days after the date such request is given, file and use its commercially reasonable efforts to cause to become effective as soon as practicable thereafter a registration statement on Form S-3 or Form F-3 (or a successor thereto) for
      all or part of the Registrable Securities on such Form S-3 or Form F-3 (or a successor thereto) pursuant to this Section 3 (a “Shelf Registration”). For the avoidance of doubt, the requirement that (i) the
      Company deliver a Company Notice within 10 days in connection with a Demand Registration and (ii) the right of Eligible Holders to request that their Registrable Securities be included in a Registration Statement filed in connection with a Demand
      Registration, each as set forth in Section 2(a), shall apply to a Demand Registration that is effected as a Shelf Registration. There shall be no limitations on the number of Shelf Registration or shelf takedowns pursuant to such Shelf Registrations;
      provided, however, that the Holders may not require the Company to effect more than two Shelf Registrations or cooperate in more than two shelf takedowns pursuant to this Section 3 in a 12-month period. If any Initiating Holder holds
      Registrable Securities included on a Shelf Registration, it shall have the right to request that the Company cooperate in a shelf takedown at any time, including an Underwritten Offering, by delivering a written request thereof to the Company
      specifying the kind and number of Registrable Securities such Initiating Holder wishes to include in the shelf takedown (“Takedown Notice”). The Company shall (i) within five (5) Business Days of the receipt of
      a Takedown Notice, give written notice of such Takedown Notice to all Holders of Registrable Securities included on such Shelf Registration (the “Company Takedown Notice”), and (ii) take all actions reasonably
      requested by the Initiating Holder who submitted the Takedown Notice, including the filing of a prospectus supplement and the other actions described in Section 6, in accordance with the intended method of distribution set forth in the Takedown
      Notice as expeditiously as practicable, and in any case, within 45 days of receipt of such Takedown Notice. If the shelf takedown is an Underwritten Offering, the Company shall include in such Underwritten Offering all Registrable Securities that the
      Holders of Registrable Securities included in the Registration Statement for such Shelf Registration request be included within the five Business Days following such Holders’ receipt of the Company Takedown Notice. If the method of distributing the
      offering is an Underwritten Offering, the Company shall include such information in the Company Takedown Notice, and the managing underwriter for such offering will be designated by the Board and shall reasonably acceptable to a majority in interest
      of the Initiating Holders. The Registrable Securities requested to be included in a Shelf Registration or in a Takedown Notice must represent a price to the public of Registrable Securities that is reasonably expected to equal at least $5,000,000.
      With respect to any Shelf Registration and subsequent shelf takedown pursuant to this Section 3(a), the Company may include in such Shelf Registration or shelf takedown any Primary Securities or Other Securities; provided, however,
      that if in connection with any shelf takedown the managing underwriter or underwriters formally advise(s) the Company in writing and with sufficient explanation that the inclusion of all Registrable Securities, Primary Securities and Other Securities
      proposed to be included in such shelf takedown would interfere with the successful marketing (including, but not limited to, pricing) of all such securities, then the number of Registrable Securities, Primary Securities and Other Securities proposed
      to be included in such shelf takedown shall be included in the following order:

    

    

    (i) first, the Registrable Securities held by the Holders requesting that their Registrable Securities be included in such shelf takedown pursuant to Section 3(a), pro rata
      based upon the number of Registrable Securities owned by each such Holder and included in the Shelf Registration at the time of such shelf takedown; provided, however, that the number of Registrable Securities held by the Holders to
      be included in such underwriting shall not be reduced unless all Primary Securities and Other Securities are first entirely excluded from the underwriting, provided that for purposes of this Subsection 3(a) concerning apportionment, any selling
      Holder and all Affiliates of that selling Holder shall be deemed to be a single “selling Holder,” and any pro rata reduction with respect to such “selling Holder” shall be based upon the aggregate number of Registrable Securities included in the
      Shelf Registration owned by all persons included in such “selling Holder,” as defined in this sentence;

    

    

    (ii) second, the Primary Securities; and

    

    

    (iii) third, the Other Securities.

    

    

    To facilitate the allocation of Ordinary Shares in accordance with the above provisions, the Company or the underwriters may round the number of Shares allocated to any
      Holder to the nearest one hundred (100) shares.

    

    

    
      

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    (b) The Company shall not be obligated file and use its commercially reasonable efforts to cause to become effective any Shelf Registration Statement or to cooperate in any shelf takedown
      pursuant to Section 3(a) (i) if the Company believes, in good faith, that it will file and cause to be effective a registration statement with respect to Primary Securities (other than on Form F-4 or Form S-8 promulgated under the Securities Act or
      any successor forms thereto) within 30 days of such a demand or (ii) if a registration statement with respect to Primary Securities (other than on Form F-4 or Form S-8 promulgated under the Securities Act or any successor forms thereto) has been
      declared effective and not withdrawn in the prior 90 days; provided that in connection with any such registration statement that has not been declared effective, the Company is in good faith using commercially reasonable efforts to cause such
      registration statement to become effective.

    

    

    (c) A requested registration under this Section 3 may be rescinded at any time prior to such registration being declared effective by the SEC by written notice to the Company from those Holders
      who initiated the request, at their discretion; provided, however, that such rescinded registration shall not count as a registration initiated pursuant to this Section 3 for purposes of this subsection (c) if (i) such request to
      rescind the registration is during a period the Company has deferred taking action pursuant to Section 3(b) above or Section 10 below or (ii) if the Company shall have been reimbursed (pro rata by the Holders requesting registration or in such
      other proportion as they may agree) for all reasonable and documented out-of-pocket expenses incurred by the Company in connection with such rescinded registration; provided, further, however, that if, at the time of such
      rescission, the Holders who initiated the request shall have learned of an event that is, or is reasonably likely to result in, a Material Adverse Change from that known to such Holders at the time of their request and have withdrawn the request with
      reasonable promptness after learning of such information then the Holders shall not be required to reimburse the Company for any out-of-pocket expenses incurred by the Company in connection with such rescinded registration and such rescinded
      registration shall not count as a registration initiated pursuant to this Section 3 for purposes of subsection (c).

    

    

    
      

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    (d) For purposes of Section 3, a registration shall not be counted as “effected” if, as a result of an exercise of the underwriter’s cutback provisions in Section 3(a), fewer than fifty percent
      (50%) of the total number of Registrable Securities that Holders have requested to be included in such registration statement are actually included.

    

    

    Section 4. PIGGYBACK REGISTRATION.

    

    

    (a) If the Company at any time proposes, for any reason, to file a Registration Statement on Form S-1, F-1, F-3 or S-3 promulgated under the Securities Act or any successor forms thereto, to
      register any Primary Securities or Other Securities under the Securities Act (other than (i) on Form F-4 or Form S-8 promulgated under the Securities Act or any successor forms thereto or (ii) to register any Primary Securities in connection with the
      IPO), it shall promptly give written notice to each holder of its intention so to register such Primary Securities or Other Securities and, upon the written request, given no later than twenty (20) days prior to such registration of Primary
      Securities or Other Securities, of any such Holder to include in such registration Registrable Securities owned by such Holder (which request shall specify the number of the Registrable Securities proposed to be included in such registration), the
      Company shall cause all such Registrable Securities to be included in such registration on the same terms and conditions as the securities otherwise being sold in such registration (such registration, a “Piggyback
        Registration”); provided, however, that if such registration is an Underwritten Offering and the managing underwriter formally advises the Company in writing and with sufficient explanation that the inclusion of all Primary
      Securities, Registrable Securities and Other Securities proposed to be included in such registration would interfere with the successful marketing (including pricing) of the Ordinary Shares proposed to be registered by the Company, then the number of
      Primary Securities, Registrable Securities and Other Securities proposed to be included in such registration shall be included in the following order:

    

    

    (i) first, Primary Securities;

    

    

    (ii) second, Registrable Securities held by the Holders requesting that Registrable Securities be included in such registration, pro rata based upon the number
      of Registrable Securities owned by each such Holder at the time of such registration, provided that for purposes of this Section 4(a) concerning apportionment, any selling Holder and all Affiliates of that selling Holder shall be deemed to be a
      single “selling Holder,” and any pro rata reduction with respect to such “selling Holder” shall be based upon the aggregate number of Registrable Securities owned by all persons included in such “selling Holder,” as defined in this sentence; provided,
      however that the Company and the underwriters in such a transaction may reduce the number of Registrable Securities proposed to be registered to a minimum of 20% of the total number of securities to be registered pursuant to any such Piggyback
      Registration; and

    

    

    (iii) third, the Other Securities held by shareholders requesting that Other Securities be included in such registration, pro rata based on the number of Other
      Securities owned by each such shareholder at the time of such registration of Other Securities (or among such shareholders in such other proportion as they shall otherwise agree).

    

    

    To facilitate the allocation of Ordinary Shares in accordance with the above provisions, the Company or the underwriters may round the number of Shares allocated to any
      Holder to the nearest one hundred (100) shares.

    

    

    provided, further, however, that if, at any time after giving written notice of its intention to Register any securities pursuant
      to this Section 4 and prior to the effective date of the Registration Statement filed in connection with such Registration, the Company shall determine for any reason not to Register or to delay Registration of such securities, the Company may, at
      its election, give written notice of such determination to each such Holder and, thereupon, (i) in the case of a determination not to Register, shall be relieved of its obligation to Register any Registrable Securities in connection with such
      Registration and shall have no liability to any Holder in connection with such termination, and (ii) in the case of a determination to delay Registration, shall be permitted to delay Registering any Registrable Securities for the same period as the
      delay in Registering such other Registrable Securities.

    

    

    
      

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    (b) For the avoidance of doubt, no Registration effected under this Section 4 shall relieve the Company of its obligations to effect any Demand Registration under Section 2 or 3 (for the
      avoidance of doubt, subject to the limitations on registration set forth in Sections 2(b), 3(b) and 10 hereof). If the offering pursuant to a Registration Statement pursuant to this Section 4 is to be an Underwritten Offering, then each Holder making
      a request for a Piggyback Registration pursuant to this Section 4 shall, and the Company shall use reasonable best efforts to coordinate arrangements with the underwriters so that each such Holder may, participate in such Underwritten Offering. If
      the offering pursuant to such Registration Statement is to be on any other basis, then each Holder making a request for a Piggyback Registration pursuant to this Section 4 shall, and the Company shall use reasonable best efforts to coordinate
      arrangements so that each such Holder may, participate in such offering on such basis. If the Company files a Shelf Registration for its own account and/or for the account of any other Persons, the Company agrees that it shall use its reasonable best
      efforts to include in such Registration Statement such disclosures as may be required by Rule 430B under the Securities Act in order to ensure that the Holders may be added to such Shelf Registration at a later time through the filing of a Prospectus
      supplement rather than a posteffective amendment. Any such Holder may withdraw its request for inclusion at any time prior to executing the underwriting agreement, or if none, prior to the applicable registration statement or prospectus supplement,
      as applicable, being filed publicly with the SEC. For certainty, any such Holder who has withdrawn its request for inclusion shall nevertheless continue to have the right to include any Registrable Securities in any subsequent registration statement
      or registration statements as may be filed by the Company with respect to offerings of its securities, all upon the terms and conditions set forth herein.

    

    

    Section 5. RULE 144 REPORTING.

    

    

    With a view to making available to the Holders the benefits of Rule 144 and any other rule or regulation of the SEC that may at any time permit a Holder to sell securities of the Company to the
      public without registration or pursuant to a registration on Form S-3 or Form F-3 (or a successor thereto), the Company shall use commercially reasonable efforts to:

    

    

    (a)          make and keep available adequate current public information, as those terms are understood and defined in
        Rule 144, at all times after the effective date of the registration statement filed by the Company for the IPO;

    

    

    (b)          use commercially reasonable efforts to file with the SEC in a timely manner all reports and other documents
        required of the Company under the Securities Act and the Exchange Act (at any time after the Company has become subject to such reporting requirements); and

    

    

    (c)          furnish to any Holder, so long as the Holder owns any Registrable Securities, forthwith upon request to the
        extent accurate, a written statement by the Company that it has complied with the reporting requirements of Rule 144 (at any time after ninety (90) days after the effective date of the registration statement filed by the Company for the IPO), the
        Securities Act, and the Exchange Act (at any time after the Company has become subject to such reporting requirements), or that it qualifies as a registrant whose securities may be resold pursuant to Form S-3 or Form F-3 (or a successor thereto)
        (at any time after the Company so qualifies).

    

    

    Section 6. PREPARATION AND FILING.

    

    

    (a) If and whenever the Company is under an obligation pursuant to the provisions of this Agreement to effect the registration of Registrable Securities, the Company shall, as expeditiously as
      practicable, and to the fullest extent permitted by applicable law:

    

    

    (i) prepare and file with the SEC a Registration Statement that registers such Registrable Securities and use its commercially reasonable efforts to cause such Registration
      Statement (or any post-effective amendment thereto) to become effective as promptly as practicable, and remain effective for a period of 120 days or until the distribution contemplated in such Registration Statement of all of such Registrable
      Securities have been completed (if earlier); provided, however, that: such 120 day period shall be extended for a period of time equal to the period a Holder refrains, at the request of an underwriter of the Company, from selling any
      securities included in such registration; provided, further, in the case of any registration of Registrable Securities on Form S-3 or Form F-3 that are intended to be offered on a continuous or delayed basis, subject to compliance
      with applicable SEC rules, such Registration Statement shall be kept effective until the earlier of such time as all such Registrable Securities are sold or such time as all Registrable Securities registered on such Registration Statement are
      eligible to be sold pursuant to Rule 144 without limitation thereunder as to volume or manner of sale;

    

    

    
      

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    (ii) prepare and file with the SEC such amendments and supplements to such Registration Statement and the Prospectus used in connection therewith as may be necessary to keep
      such Registration Statement effective for the lesser of the period required pursuant to clause (i) of this Section 6(a) or until all of the Registrable Securities have been disposed of (if earlier) and to comply with the provisions of the Securities
      Act with respect to the sale or other disposition of such Registrable Securities;

    

    

    (iii) furnish, in reasonable advance of any public filing, drafts of a Registration Statement that registers Registrable Securities, a Prospectus relating thereto and any
      amendments or supplements relating to such Registration Statement or Prospectus, to one special counsel selected by a Holder Majority (the “Holders’ Counsel”) copies of all such documents proposed to be filed
      and such other documents as the Holders may reasonably request, and consider in good faith any comments of any Holder selling Registrable Securities and their respective counsel on such documents;

    

    

    (iv) use its commercially reasonable efforts to register or qualify, or obtain exemption from the registration or qualification requirements for, Registrable Securities under
      such other securities or blue sky laws of such jurisdictions as any seller of the Registrable Securities reasonably requests and take any and all other measures and do all other things which may be reasonably necessary or advisable to enable such
      seller of the Registrable Securities to consummate the disposition thereof in such jurisdictions; provided, however, that the Company will not be required to qualify generally to do business, subject itself to general taxation or
      consent to general service of process in any jurisdiction where it would not otherwise be required so to do but for this clause (iv), unless the Company is already subject to service in such jurisdiction and except as may be required by the
      Securities Act;

    

    

    (v) in the event of any underwritten public offering, enter into and perform its obligations under an underwriting agreement, in usual and customary form, with the
      underwriter(s) of such offering

    

    

    (vi) use its commercially reasonable efforts to cause all Registrable Securities covered by such registration statement on any United States national securities exchange on
      which any Ordinary Shares are listed;

    

    

    (vii) provide a transfer agent and registrar for all Registrable Securities registered pursuant to this Agreement and request the registrar to provide a CUSIP number for all
      such Registrable Securities, in each case not later than the effective date of such registration;

    

    

    (viii) promptly make available for inspection by any seller of the Registrable Securities, any underwriter participating in any disposition pursuant to such Registration
      Statement and any attorney, accountant or other representative retained by any such seller or underwriter, all pertinent financial, business and other records and documents as shall be reasonably necessary to enable them to conduct appropriate due
      diligence, and cause the Company’s officers, directors and employees to supply all information reasonably requested by any such seller, underwriter, attorney, accountant or other representative in connection with such Registration Statement;

    

    

    (xi) notify the Holders’ Counsel promptly in writing (A) of any comments by the SEC with respect to such Registration Statement or Prospectus, or any request by the SEC for
      the amending or supplementing thereof or for additional information with respect thereto, (B) of the effectiveness of such Registration Statement or any amendment thereto or of the filing of such Prospectus or any supplement thereto and the issuance
      by the SEC of any stop order suspending the effectiveness of such Registration Statement or any amendment thereto or the initiation of any proceedings for that purpose and (C) of the receipt by the Company of any notification with respect to the
      suspension of the qualification of the Registrable Securities for sale in any jurisdiction or the initiation or threatening of any proceeding for such purposes;

    

    

    
      

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    (x) notify each Holder, promptly after the Company receives notice thereof, of the time when such Registration Statement has been declared effective or a supplement to any
      Prospectus forming a part of such Registration Statement has been filed;

    

    

    (xi) after such Registration Statement becomes effective, notify each Holder of any request by the SEC that the Company amend or supplement such registration statement or
      Prospectus;

    

    

    (xii) use its commercially reasonable efforts to prevent the issuance of any stop order or other suspension of effectiveness of a Registration Statement, or the suspension of
      the qualification of any of the Registrable Securities for sale in any jurisdiction and, if such an order or suspension is issued, use its commercially reasonable efforts to obtain the withdrawal of such order or suspension at the earliest possible
      moment and to notify the Holders of the issuance of any such order and the resolution thereof or its receipt of actual notice of the initiation or threat of any proceeding for such purpose;

    

    

    (xiii) furnish without charge to each seller of the Registrable Securities such number of copies of any Prospectus, including a preliminary Prospectus, in conformity with the
      requirements of the Securities Act, and such other documents as such seller of the Registrable Securities may reasonably request in order to facilitate the public sale or other disposition of the Registrable Securities;

    

    

    (xiv) prepare, file and/or make available to the public and/or Holders any documents that comply with all relevant applicable regulations and that do not have any material
      omissions or misstatements;

    

    

    (xv) notify on a timely basis each seller of the Registrable Securities at any time when a Prospectus relating to the Registrable Securities is required to be delivered under
      the Securities Act within the appropriate period mentioned in clause (i) of Section 6(a) of the happening of any event as a result of which the Prospectus included in such Registration Statement, as then in effect, includes an untrue statement of a
      material fact or omits to state a material fact required to be stated therein or necessary to make the statements therein not misleading in light of the circumstances then existing, promptly prepare and file a supplement or amendment to such
      Prospectus as may be necessary so that, as supplemented or amended, such Prospectus shall cease to include an untrue statement of a material fact or omit to state a material fact required to be stated therein or necessary to make the statements
      therein not misleading in light of the circumstances in which they were made;

    

    

    (xvi) use its commercially reasonable efforts to obtain from its independent certified public accountants a “comfort” letter in customary form and covering such matters of
      the type customarily covered by comfort letters;

    

    

    (xvii) use its commercially reasonable efforts to provide (A) a legal opinion of the Company’s outside counsel dated the effective date of such registration statement
      addressed to the Company and to each Holder selling Registrable Securities addressing the validity of the Registrable Securities being offered thereby, (B) on the date that such Registrable Securities are delivered to the underwriters for sale, if
      such Registrable Securities are being sold through underwriters, or, if such Registrable Securities are not being sold through underwriters, on the closing date of the applicable sale, (1) one or more legal opinions of the Company’s outside counsel,
      dated such date, in form and substance as customarily given to underwriters in an underwritten public offering or, in the case of a non-underwritten offering, to the broker, placement agent or other agent of the Holders assisting in the sale of the
      Registrable Securities and (2) one or more “negative assurances letters” of the Company’s outside counsel, dated such date, in form and substance as is customarily given to underwriters in an underwritten public offering or, in the case of a
      non-underwritten offering, to the broker, placement agent or other agent of the Holders assisting in the sale of the Registrable Securities, in each case, addressed to the underwriters, if any, or, if requested, in the case of a non-underwritten
      offering, to the broker, placement agent or other agent of the Holders assisting in the sale of the Registrable Securities and (C) customary certificates executed by authorized officers of the Company as may be requested by any Holder or any
      underwriter of such Registrable Securities;

    

    

    (xviii) obtain the approval of all Governmental Authorities and self-regulatory bodies as may be necessary to effect the registration of the Registrable Securities and
      consummate the disposition of such Registrable Securities pursuant to the Registration Statement;

    

    

    (xiv) make available one or more senior executives for participation in roadshows and other marketing activities in connection with any Underwritten Offering as the Company
      and the underwriters for such offering may reasonably agree, but in any event subject to the limitation that such officer’s or officers’ participation shall not negatively interfere with the Company’s normal course of business; and

    

    

    (xx) otherwise use its commercially reasonable efforts to take all other steps necessary to effect the registration of the Registrable Securities contemplated hereby.

    

    

    
      

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    (b) Each Holder of Registrable Securities that sells Registrable Securities pursuant to a registration under this Agreement agrees that during such time as such seller may be engaged in a
      distribution of the Registrable Securities, such seller shall comply with Regulation M promulgated under the Exchange Act and pursuant thereto it shall, among other things: (i) distribute the Registrable Securities under the Registration Statement
      solely in the manner described in the Registration Statement covering such Registrable Securities; and (ii) cease distribution of the Registrable Securities pursuant to such Registration Statement upon receipt of written notice from the Company that
      the Prospectus covering the Registrable Securities contains any untrue statement of a material fact or omits a material fact required to be stated therein or necessary to make the statements therein not misleading.

    

    

    Section 7. EXPENSES.

    

    

    All expenses incurred by the Company in complying with Section 5, including all registration and filing fees (including all expenses incident to filing with FINRA), fees and expenses of
      complying with securities and blue sky laws, printing expenses, fees and expenses of the Company’s counsel and accountants and fees, as well as the reasonable fees and expenses of Holders’ Counsel not to exceed $25,000 (the “Holders’ Counsel Reimbursement Cap”) shall be paid by the Company to the fullest extent permitted by applicable law, provided, however, that that the Company shall not be required to pay for any expenses of any
      registration pursuant to a Demand Registration pursuant to Section 2 if the Demand Notice is subsequently withdrawn at the request of the Holders of a majority of the Registrable Securities to be registered (in which case all selling Holders shall
      bear such expenses pro rata based upon the number of Registrable Securities that were to be included in the withdrawn registration), unless the Holders of a majority of the Registrable Securities agree to forfeit their right to one
      registration pursuant to Section 3 or Section 4, as the case may be. All expenses incurred by any Holder in connection with any sale of Registrable Securities under this Agreement, including share transfer taxes and the underwriting discounts and
      commissions and brokerage fees and expenses incurred in connection with the sale of Registrable Securities by any Holder, such Holder’s pro rata share of the fees and expenses of Holders’ Counsel in excess of the Holders’ Counsel
      Reimbursement Cap and the out-of-pocket expenses incurred by the Company for which the Holders are responsible, if any, pursuant to Sections 2(d) and 3(c), shall be paid by such Holder, except that the Company shall pay the reasonable fees and
      expenses of Company’s counsel in each relevant jurisdiction, to the extent required by the underwriters or the rules and regulations of the SEC to deliver an opinion or other documentation in connection with an offering, in any offerings pursuant to
      Section 2, 3 or 4.

    

    

    Section 8. INDEMNIFICATION.

    

    

    (a) In connection with any registration of Registrable Securities under the Securities Act pursuant to this Agreement, the Company will, and hereby agrees to, and hereby does, indemnify and
      hold harmless, to the fullest extent permitted by applicable law the seller of such Registrable Securities, and each other Person, if any, who controls such seller and each officer, director, partner, member and registered investment advisor or
      subadvisor of any of the foregoing Persons (each an “Indemnified Seller”), against any losses, claims, damages or liabilities, joint or several, to which any of the foregoing Persons become subject under the
      Securities Act or otherwise, insofar as such losses, claims, damages or liabilities (or actions in respect thereof) arise out of or are based upon an untrue statement or alleged untrue statement of a material fact contained in the Registration
      Statement under which Registrable Securities were registered, any preliminary Prospectus or final Prospectus contained therein, any amendment or supplement thereto, any free writing prospectus or any document incident to registration or qualification
      of Registrable Securities, including any marketing materials, or arise out of or are based upon the omission or alleged omission to state therein a material fact required to be stated therein or necessary to make the statements therein not misleading
      or, with respect to any Prospectus, necessary to make the statements therein in light of the circumstances under which they were made not misleading, and the Company shall promptly reimburse, to the fullest extent permitted by applicable law, such
      Indemnified Seller for any reasonable legal or other expenses actually incurred by any of them in connection with investigating or defending any such loss, claim, damage, liability or action; provided, however, that the Company shall
      not be liable to any such Indemnified Seller to the extent that any such loss, claim, damage or liability arises out of or is based upon an untrue statement or alleged untrue statement or omission or alleged omission made in said Registration
      Statement, preliminary Prospectus, amendment, supplement, free writing prospectus or document incident to registration or qualification of any Registrable Securities in reliance upon and in conformity with written information furnished to the Company
      by such Indemnified Seller, or a Person duly acting on its behalf, specifically for use in the preparation thereof, provided, further, that indemnification pursuant to this Section 8(a) shall not apply to amounts paid in settlement of
      any such claim or proceeding if such settlement is effected without the consent of the Company, which consent shall not be unreasonably withheld.

    

    

    
      

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    (b) In connection with any registration of Registrable Securities under the Securities Act pursuant to this Agreement, each seller of Registrable Securities shall, severally and not jointly,
      indemnify and hold harmless the Company, to the fullest extent permitted by applicable law, each other seller of Registrable Securities under such registration, each Person who controls any of the foregoing Persons within the meaning of the
      Securities Act and each officer, director, partner, and member of any of the foregoing Persons, against any losses, claims, damages or liabilities to which any of the foregoing Persons may become subject under the Securities Act or otherwise, insofar
      as such losses, claims, damages or liabilities (or actions in respect thereof) arise out of or are based upon an untrue statement or alleged untrue statement of a material fact contained in the Registration Statement under which Registrable
      Securities were registered, any preliminary Prospectus or final Prospectus contained therein, any amendment or supplement thereto, any free writing prospectus or any document incident to registration or qualification of any Registrable Securities, if
      such statement or omission was made in reliance upon and in conformity with written information furnished to the Company by such seller specifically for use in connection with the preparation of such Registration Statement, preliminary Prospectus,
      final Prospectus, amendment or supplement; provided, however, that the maximum amount of liability in respect of such indemnification shall be limited, in the case of each seller of Registrable Securities, to an amount equal, when
      combined with the amount of any contribution under Section 8(d) below, to the net proceeds (after the payment of underwriting discounts and commissions) actually received by such seller from the sale of Registrable Securities effected pursuant to
      such registration, provided, further, that indemnification pursuant to this Section 8(a) shall not apply to amounts paid in settlement of any such claim or proceeding if such settlement is effected without the consent of the sellers
      of Registrable Securities, which consent shall not be unreasonably withheld.

    

    

    (c) Promptly after receipt by an indemnified party of notice of the commencement of any action involving a claim referred to in the preceding paragraphs of this Section 8, such indemnified
      party will, if a claim in respect thereof is made against an indemnifying party, give written notice to the latter of the commencement of such action; provided, however, that an indemnified party’s failure to give such notice in a
      timely manner shall only relieve the indemnification obligations of an indemnifying party to the extent such indemnifying party is prejudiced or harmed by such failure. In case any such action is brought against an indemnified party, the indemnifying
      party will be entitled to participate in and to assume the defense thereof, jointly with any other indemnifying party similarly notified to the extent that it may wish, with counsel reasonably satisfactory to such indemnified party, and after notice
      from the indemnifying party to such indemnified party of its election so to assume the defense thereof, the indemnifying party shall not be responsible for any legal or other expenses subsequently incurred by the indemnified party in connection with
      the defense thereof; provided, however, that if any indemnified party shall have reasonably concluded that there may be one or more legal or equitable defenses available to such indemnified party that conflict with those available to
      the indemnifying party, the indemnifying party shall not have the right to assume the defense of such action on behalf of such indemnified party and such indemnifying party shall reimburse such indemnified party and any Person controlling such
      indemnified party for that portion of the reasonably incurred and documented fees and expenses of any one lead counsel retained by the indemnified party in connection with the matters covered by the indemnity agreement provided in this Section 8. If
      the defense is assumed by the indemnifying party, the indemnifying party shall not be liable for any settlement of any action, claim or proceeding effected by the indemnified party without its prior written consent; provided, however,
      that the indemnifying party shall not unreasonably withhold, delay or condition its consent. No indemnifying party shall, without the prior written consent of the indemnified party, consent to entry of any judgment or enter into any settlement or
      other compromise which does not include as an unconditional term thereof the giving by the claimant or plaintiff to such indemnified party of a release from all liability in respect to such action, claim or proceeding.

    

    

    (d) If, other than for the reason set forth in the proviso to the first sentence in Section 8(c), the indemnification provided for in this Section 8 is held by a court of competent jurisdiction
      to be unavailable to an indemnified party with respect to any loss, claim, damage or liability referred to herein, then the indemnifying party, in lieu of indemnifying such indemnified party hereunder, shall, to the fullest extent permitted by
      applicable law contribute to the amounts paid or payable by such indemnified party as a result of such loss, claim, damage or liability in such proportion as is appropriate to reflect the relative fault of the indemnifying party on the one hand and
      of the indemnified party on the other hand in connection with the statements or omissions which resulted in such loss, claim, damage or liability as well as any other relevant equitable considerations; provided, however, that the
      maximum amount of liability in respect of such contribution shall be limited, in the case of each seller of Registrable Securities, when combined with the amount of any indemnification pursuant to Section 8(b) above, to an amount equal to the net
      proceeds (after the payment of underwriting discounts and commissions) actually received by such seller from the sale of Registrable Securities effected pursuant to such registration, except in the case of willful misconduct or fraud by such Holder.
      The relative fault of the indemnifying party and of the indemnified party shall be determined by reference to, among other things, whether the untrue or alleged untrue statement of a material fact or the omission to state a material fact relates to
      information supplied by the indemnifying party or by the indemnified party and the parties’ relative intent, knowledge, access to information and opportunity to correct or prevent such statement or omission. The parties hereto agree that it would not
      be just and equitable if contribution pursuant to this Section 8(d) were determined by pro rata allocation or by any other method of allocation that does not take account of the equitable considerations referred to in this Section
      8(d). Further, no Person guilty of fraudulent misrepresentation (within the meaning of Section 10(f) of the Securities Act) will be entitled to contribution from any Person who was not guilty of such fraudulent misrepresentation.

    

    

    
      

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    (e) The indemnification and contribution provided for under this Agreement will be in addition to any other rights to indemnification or contribution that any indemnified party may have
      pursuant to law or contract (and the Company and its subsidiaries shall be considered the indemnitors of first resort in all such circumstances to which this Section 8 applies) and will remain in full force and effect regardless of any investigation
      made by or on behalf of the indemnified party or any officer, director or controlling Person of such indemnified party.

    

    

    Section 9. UNDERWRITING AGREEMENT.

    

    

    (a) Notwithstanding the provisions of Sections 7 and 8, to the extent that the Holders selling Registrable Securities in a proposed registration shall, to the fullest extent permitted by
      applicable law, enter into an underwriting or similar agreement, which agreement contains provisions covering one or more issues addressed in such Sections of this Agreement (it is understood and agreed that, for purposes of this clause (a), any
      indemnification provisions in any such underwriting or similar agreement that does not provide for the indemnification by the Company of a seller of Registrable Securities and other Persons or the indemnification by the seller of Registrable
      Securities of the Company and other Persons shall not supersede Section 8(a) or 8(b) above), the provisions contained in such Sections of this Agreement addressing such issue or issues shall be of no force or effect with respect to such registration,
      but this provision shall not apply to the Company if the Company is not a party to the underwriting or similar agreement.

    

    

    (b) If any registration pursuant to Sections 2 or 3 is requested to be an Underwritten Offering, the Company shall negotiate in good faith to enter into a reasonable and customary underwriting
      agreement with the underwriters thereof. The Company shall, to the fullest extent permitted by applicable law, be entitled to receive indemnities from lead institutions, underwriters, dealer managers and similar securities industry professionals
      participating in the distribution, to the same extent as provided above with respect to information so furnished in writing by such Persons specifically for inclusion in any Prospectus or Registration Statement and to the extent customary given their
      role in such distribution.

    

    

    (c) No Holder may participate in any registration hereunder that is underwritten unless such Holder agrees to (i) sell Registrable Securities proposed to be included therein on the basis
      provided in any underwriting arrangements acceptable to the Company and a Holder Majority and (ii) as expeditiously as possible, notify the Company of the occurrence of any event concerning such Holder as a result of which the Prospectus relating to
      such registration contains an untrue statement of a material fact or omits to state a material fact required to be stated therein or necessary to make the statements therein, in light of the circumstances under which they were made, not misleading.
      Notwithstanding the foregoing, no Holder shall be required to make any representations or warranties to the Company or the underwriters (other than representations and warranties regarding (i) such Holder’s ownership of Registrable Securities to be
      transferred free and clear of all liens, claims and encumbrances created by such Holder, (ii) such Holder’s power and authority to effect such transfer, (iii) such matters pertaining to such Holder’s compliance with securities laws as reasonably may
      be requested and (iv) such Holder’s intended method of distribution) or to undertake any indemnification obligations to the Company with respect thereto, except as otherwise provided in Section 8 hereof.

    

    

    
      

      15

      
        


      

    

    

    

    Section 10. SUSPENSION.

    

    

    Anything contained in this Agreement to the contrary notwithstanding, the Company may by notice in writing to each Holder of Registrable Securities to which a Prospectus relates, delay, for up
      to 90 calendar days (the “Delay/Suspension Period”), the filing or the effectiveness of any Registration Statement filed (or to be filed) under Section 2, 3 or 4 or require such Holder to suspend, for up to the
      Delay/Suspension Period the use of any Prospectus included in a Registration Statement filed under Sections 2, 3 or 4 if at the time of such delay or suspension, the Company furnishes to the requesting Holders a certificate signed by the Company’s
      chief executive officer stating that in the good faith judgment of the Board, the Board considers that it would be materially detrimental for the Registration Statement to become or remain effective because such action would: (a) interfere with a
      Material Transaction, (b) require premature disclosure of material information that the Company has a bona fide business purpose for preserving as confidential or (c) render the Company unable to comply with requirements under the
      Securities Act or the Exchange Act; and provided, that the Company may not invoke this right more than once in any 12 month period. The period during which such registration must remain effective shall be extended by a period equal to the
      Delay/Suspension Period. The Company may (but shall not be obligated to) withdraw the effectiveness of any Registration Statement subject to this provision.

    

    

    Section 11. INFORMATION BY HOLDER.

    

    

    Each Holder of Registrable Securities to be included in any registration shall promptly furnish to the Company and the managing underwriter such customary written information regarding such
      Holder and the distribution proposed by such Holder as the Company or the managing underwriter may reasonably request in writing at least four Business Days prior to the first anticipated filing date of any Registration Statement or amendment
      thereto, or Prospectus, as applicable, and as shall be reasonably required in connection with any registration, qualification or compliance referred to in this Agreement. It is understood and agreed that the obligations of the Company under Sections
      2, 3 and 4 with respect to any particular Holder are conditioned on the timely provisions of the foregoing information by each such Holder and, without limitation of the foregoing, will be conditioned on compliance by each such Holder with the
      following:

    

    

    (a) each such Holder will, and will cause its Affiliates to, cooperate with the Company as reasonably requested by the Company in connection with the preparation of the applicable registration
      statement, and for so long as the Company is obligated to keep such registration statement effective, such Holder will and will cause its Affiliates to, provide to the Company, in writing and in a timely manner, for use in such registration statement
      (and expressly identified in writing as such), all customary information reasonably requested by the Company regarding itself and its Affiliates and such other customary information as may reasonably be requested by the Company or required by
      applicable law to enable the Company to prepare such registration statement and the related prospectus covering the Registrable Securities owned by such Holder and to maintain the currency and effectiveness thereof;

    

    

    (b) each such Holder shall, and it shall cause its Affiliates to, supply to the Company, its representatives and agents in a timely manner any customary information regarding itself and its
      Affiliates as the Company, its representatives or agents may be reasonably requested to provide in connection with the offering or other distribution of Registrable Securities by such Holder; and

    

    

    (c) on receipt of written notice from the Company upon the occurrence of any of the events specified in Section 10, or that requires the suspension by such Holder and its Affiliates of the
      distribution of any Registrable Securities owned by such Holder pursuant to applicable law, then such Holder shall, and it shall cause its Affiliates to, cease offering or distributing such Registrable Securities owned by such Holder until the
      offering and distribution of Registrable Securities owned by such Holder may recommence in accordance with the terms hereof and applicable law.

    

    

    Section 12. TERMINATION.

    

    

    This Agreement shall terminate and be of no further force or effect upon the earliest to occur of: (i) when there shall not be any Registrable Securities, (ii) upon the occurrence of an Asset
      sale or a Deemed Liquidation Event in which the consideration received by the Investors in such Asset Sale or Deemed Liquidation Event is in the form of cash and/or publicly traded securities, or if the Investors receive registration rights from the
      acquiring company or other successor to the Company reasonably comparable to those set forth, (iii) all Registrable Securities are eligible to be sold pursuant to Rule 144 without limitation thereunder as to volume or manner of sale, or (iv) the date
      that is three years from the closing of the IPO; provided, however, that Sections 8 and 9 shall survive the termination of this Agreement. In addition, the Company shall have no obligation pursuant to this Agreement with respect to
      any Registrable Securities proposed to be sold by a Holder in a Registration pursuant to this Agreement if all such securities proposed to be sold by such Holder are eligible to be sold pursuant to Rule 144 without limitation thereunder as to volume
      or manner of sale.

    

    

    
      

      16

      
        


      

    

    

    

    Section 13. LIMITATION ON OTHER REGISTRATION RIGHTS.

    

    

    The Company agrees that it shall not enter into any agreement with any holder or prospective holder of any securities of the Company that is not a party to this Agreement so long as any
      Registrable Securities are outstanding without the prior written consent of a Holder Majority (i) that would allow such holder or prospective holder to include such securities in any Demand Registration, Shelf Registration or Piggyback Registration
      unless, under the terms of such agreement, such holder or prospective holder may include such securities in any such registration only on a pro rata basis or on a subordinate basis to the extent that their inclusion would not reduce the amount of the
      Registrable Securities of the Holders included therein or (ii) allow such holder or prospective holder to initiate a demand for registration of any securities held by such holder or prospective holder.

    

    

    Section 14. MISCELLANEOUS.

    

    

    14.1 NOTICES. All notices or other communications required or permitted hereunder shall be given in writing and given by certified or registered mail, return receipt requested,
      nationally recognized overnight delivery service, such as Federal Express, facsimile or e-mail with confirmation of transmission by the transmitting equipment or personal delivery against receipt to the party to whom it is given, in each case, at
      such party’s address, facsimile number or e-mail address set forth below or such other address, facsimile number or e-mail address as such party may hereafter specify by notice to the other parties hereto given in accordance herewith. Any such notice
      or other communication shall be deemed to have been given as of the date so personally delivered or transmitted by facsimile, e-mail or like transmission (or, if delivered or transmitted after normal business hours, on the next Business Day):

    

    

    if to the Company, to:

    

    

    GH Research PLC

    28 Baggot Street Lower

    Dublin 2

    D02 NX43

    Ireland

    Telephone: +353 1 437 8443

    e-mail: [●]

    Attention: [●]

    

    

    with a copy to:

    

    

    Davis Polk & Wardwell LLP

    450 Lexington Avenue

    New York, NY 10017

    Telephone: +1 (212) 450 4389

    e-mail: yasin.keshvargar@davispolk.com

    Attention: Yasin Keshvargar

    

    

    if to a Holder, to its address on a signature page hereto or, if none, in the books of the Company.

    

    

    14.2 ASSIGNMENT. Except as otherwise expressly provided herein, this Agreement and all of the provisions hereof shall be binding upon and inure to the benefit of the parties hereto and
      their respective heirs (in the case of any individual), successors and permitted assigns; provided, however, that neither this Agreement nor any of the rights, interests or obligations hereunder may be assigned by any Holder without
      the prior written consent of the Company; provided, further, however, that, notwithstanding the provisions of the foregoing proviso, to the extent that any Holder transfers any Registrable Securities to any Permitted
      Transferee in a transaction that does not violate the Constitution and is otherwise permissible under applicable law, such Holder may transfer and assign, without the prior written consent of the Company, its rights, interests or obligations
      hereunder with respect to such Registrable Securities hereunder to such Permitted Transferee.

    

    

    
      

      17

      
        


      

    

    

    

    Notwithstanding the foregoing, in each case, if such transfer is subject to covenants, agreements or other undertakings restricting transferability thereof, the registration rights provided for
      hereunder shall not be transferred in connection with such transfer unless such transferee complies with all such covenants, agreements and other undertakings.

    

    

    Any purported assignment or delegation in violation of this Agreement shall be null and void ab initio.

    

    

    14.3 ENTIRE AGREEMENT. This Agreement embodies the entire agreement and understanding of the parties and their respective Affiliates with respect to the transactions contemplated hereby
      and supersedes and cancels all prior written or oral commitments, arrangements or understandings with respect thereto. There are no restrictions, agreements, promises, warranties, covenants or undertakings with respect to the transactions
      contemplated hereby other than those expressly set forth in this Agreement.

    

    

    14.4 MODIFICATIONS, AMENDMENTS AND WAIVERS. This Agreement may not be modified or amended except by an instrument or instruments in writing that expressly states that it is modifying or
      amending this Agreement and that is signed by the Company and a Holder Majority. Any party hereto (or a Holder Majority) may, only by an instrument in writing that expressly states that it is waiving compliance with this Agreement, waive compliance
      by any other party or parties hereto with any term or provision hereof on the part of such other party or parties hereto to be performed or complied with. Notwithstanding the foregoing, the terms and conditions of this Agreement as they apply to any
      Holder of the Company’s securities or related parties may not be modified or amended in any manner that results in a non-pro rata material adverse effect on the rights of such Holder without the prior written consent of such Holder. No
      failure or delay of any party in exercising any right or remedy hereunder shall operate as a waiver thereof, nor will any single or partial exercise of any right or power, or any abandonment or discontinuance of steps to enforce such right or power,
      preclude any other or further exercise thereof or the exercise of any other right or power. The waiver by any party hereto of a breach of any term or provision hereof shall not be construed as a waiver of any subsequent breach. The rights and
      remedies of the parties hereunder are cumulative and are not exclusive of any rights or remedies that they would otherwise have hereunder.

    

    

    14.5 COUNTERPARTS. This Agreement may be executed in one or more counterparts, all of which shall be considered one and the same agreement and each of which shall be deemed an original,
      and will become effective when one or more counterparts have been signed by a party and delivered to the other parties. Copies of executed counterparts transmitted by telecopy, telefax or other electronic transmission service shall be considered
      original executed counterparts for purposes of this Section 14.5, provided that receipt of copies of such counterparts is confirmed.

    

    

    14.6 GOVERNING LAW. THIS AGREEMENT SHALL BE GOVERNED BY AND CONSTRUED IN ACCORDANCE WITH THE LAWS OF THE STATE OF NEW YORK THAT APPLY TO CONTRACTS MADE AND PERFORMED ENTIRELY IN SUCH
      STATE.

    

    

    14.7 SUBMISSION TO JURISDICTION; WAIVER OF JURY TRIAL. Each party to this Agreement, for itself and its Affiliates, hereby irrevocably and unconditionally:

    

    

    (a) (i) agrees that any suit, action or proceeding instituted against it by any other party with respect to this Agreement may be instituted, and that any suit, action or proceeding by it
      against any other party with respect to this Agreement shall be instituted, only in the courts of the State of New York, located in New York County or the U.S. District Court for the Southern District of New York (and appellate courts from any of the
      foregoing) as the party instituting such suit, action or proceeding may in its sole discretion elect, (ii) consents and submits, for itself and its property, to the jurisdiction of such courts for the purpose of any such suit, action or proceeding
      instituted against it by any other party and (iii) agrees that a final judgment in any such suit, action or proceeding shall be conclusive and may be enforced in other jurisdictions by suit on the judgment or in any other manner provided by law;

    

    

    
      

      18

      
        


      

    

    

    

    (b) agrees that service of all writs, process and summonses in any suit, action or proceeding pursuant to Section 14.7(a) may be effected by the mailing of copies thereof by registered or
      certified mail, postage prepaid, to the Company or the applicable Holder, as the case may be, at the addresses for notices pursuant to Section 14.1 (with copies to such other Persons as specified therein); provided, however, that: (i)
      the Company agrees that the documents which start any proceedings and any other documents required to be served in relation to those proceedings may be served on it by being delivered to Cogency Global, Inc. at 122 East 42nd Street, 18th Floor New
      York, NY 10168 or, if different, its registered office for the time being, and if such Person is not or ceases to be effectively appointed to accept service of process on behalf of the Company, the Company shall, appoint a further person in New York
      to accept service of process on its behalf and, failing such appointment within 30 days, the Holders jointly shall be entitled to appoint such a person by written notice addressed to the Company and delivered to the Company; provided, however,
      that a copy of any such documents shall in each instance be delivered to Davis Polk & Wardwell LLP at the address provided in Section 14.1, above; and (ii) nothing contained in this Section 14.7 shall affect the right of the Company or any Holder
      to serve process in any other manner permitted by law;

    

    

    (c) (i) waives any objection that it may now or hereafter have to the laying of venue of any suit, action or proceeding arising out of or relating to this Agreement brought in any court
      specified in Section 14.7(a), (ii) waives any claim that any such suit, action or proceeding brought in any such court has been brought in an inconvenient forum and (iii) agrees not to plead or claim either of the foregoing;

    

    

    (d) WAIVES ANY RIGHT IT MAY HAVE TO A TRIAL BY JURY OF ANY DISPUTE ARISING OUT OF OR RELATING TO THIS AGREEMENT AND AGREES THAT ANY SUCH DISPUTE SHALL BE TRIED BEFORE A JUDGE SITTING WITHOUT A
      JURY; and

    

    

    (e) to the extent it has or hereafter may acquire any immunity from jurisdiction of any court or from any legal process (whether through service or notice, attachment prior to judgment,
      attachment in aid of execution, execution or otherwise) with respect to itself, or its property, hereby irrevocably waives such immunity in respect of its obligations with respect to this Agreement.

    

    

    14.8 SEVERABILITY. To the fullest extent permissible under applicable law, the parties hereto hereby waive any provision of law which renders any provision of this Agreement invalid,
      illegal or unenforceable in any respect. Such parties further agree that any provision of this Agreement which, notwithstanding the preceding sentence, is rendered or held invalid, illegal or unenforceable in any respect in any jurisdiction shall be
      ineffective, but such ineffectiveness shall be limited as follows: (a) if such provision is rendered or held invalid, illegal or unenforceable in such jurisdiction only as to a particular Person or Persons or under any particular circumstance or
      circumstances, such provision shall be ineffective, but only in such jurisdiction and only with respect to such particular Person or Persons or under such particular circumstance or circumstances, as the case may be; (b) without limitation of clause
      (a), such provision shall in any event be ineffective only as to such jurisdiction and only to the extent of such invalidity, illegality or unenforceability, and such invalidity, illegality or unenforceability in such jurisdiction shall not render
      invalid, illegal or unenforceable such provision in any other jurisdiction; and (c) without limitation of clause (a) or (b), such ineffectiveness shall not render invalid, illegal or unenforceable this Agreement or any of the remaining provisions
      hereof.

    

    

    14.9 NO THIRD PARTY BENEFICIARY. Except for the Persons indemnified pursuant to Section 8(a) or 8(b), this Agreement is for the sole benefit of the parties hereto and their respective
      successors and permitted assigns and nothing herein, express or implied, is intended to or shall confer upon any other Person any legal or equitable right, benefit or remedy of any nature whatsoever under or by reason of this Agreement, except that
      any nominee holding Registrable Securities beneficially for an Investor may enforce this Agreement as if it were a Holder, provided, however, that (i) the name of any such nominee shall be previously disclosed to the Company in
      writing, and (ii) such nominee will have no investment discretion with respect to the Registrable Securities, and such Investor will remain the beneficial owner of the Registrable Securities for all purposes.

    

    

    14.10 NON-RECOURSE. No past, present or future director, officer, employee, incorporator, member, manager, partner, shareholder, Affiliate, agent, attorney, consultant, representative
      or principal of the Company or any Affiliate of the Company shall have any liability for any liabilities of the Company under this Agreement or for any claim based on, in respect of, or by reason of, the transactions contemplated hereby.

    

    

    
      

      19

      
        


      

    

    

    

    14.11 SPECIFIC PERFORMANCE. Each of the parties hereto acknowledges that the others would not have an adequate remedy at law for money damages in the event that any of the covenants or
      agreements set forth in this Agreement were not performed in accordance with its terms and therefore, each of the parties agrees that the others shall be entitled to specific performance, injunctive and other equitable relief in addition to any other
      remedy to which it may be entitled at law or in equity (without the necessity of proving the inadequacy as a remedy of money damages or the posting of a bond).

    

    

    14.12 BUSINESS DAYS. If any date provided for in this Agreement shall fall on a day that is not a Business Day, the date provided for shall be deemed to refer to the next Business Day.

    

    

    14.13 ELECTRONIC EXECUTION. Delivery of an executed counterpart of a signature page of this Agreement and any other Transaction Document by telecopy or electronic format (including pdf)
      shall be effective as delivery of a manually executed counterpart of this Agreement or other Transaction Document.

    

    

    14.14 CAPTIONS. Article and Section headings and the Table of Contents used herein are for convenience of reference only, are not part of this Agreement, and shall not affect the
      construction of, or be taken into consideration in interpreting, this Agreement.

    

    

    [Signature Pages Follow]

    

    

    
      

      20

      
        


      

    

    The parties have executed and delivered this Registration Rights Agreement as of the date first written above.

    

    

    	 	
            GH RESEARCH PLC

          	 
	 	 	 
	 	
            By:

          	 
	 	 	
            Name:

          	 
	 	 	
            Title:

          	 


    

    

    

    

    
      
        
          [Company Signature Page to Registration Rights Agreement]

        

      

      
        


      

    

    	 	
            FLORIAN SCHÕNHARTING

          	 
	 	 	 
	 	
            By:

          	 
	 	 	
            Name:

          	 
	 	 	
            Title:

          	 


    

    

    

    

    
      
        
          [Shareholder Signature Page to Registration Rights Agreement]

        

      

      
        


      

    

    	 	
            DUNE CAPITAL

          	 
	 	 	 
	 	
            By:

          	 
	 	 	
            Name:

          	 
	 	 	
            Title:

          	 


    

    

    

    

    
      
        
          [Shareholder Signature Page to Registration Rights Agreement]

        

      

      
        


      

    

    	 	
            INWOOD SETTLEMENT

          	 
	 	 	 
	 	
            By:

          	 
	 	 	
            Name:

          	 
	 	 	
            Title:

          	 


    

    

    

    

    
      
        
          [Shareholder Signature Page to Registration Rights Agreement]

        

      

      
        


      

    

    	 	
            BIOTECHNOLOGY VALUE FUND L.P.

          	 
	 	 	 
	 	
            By:

          	 
	 	 	
            Name:

          	 
	 	 	
            Title:

          	 


    

    

    

    

    
      
        
          [Shareholder Signature Page to Registration Rights Agreement]

        

      

      
        


      

    

    	 	
            BIOTECHNOLOGY VALUE FUND II, L.P.

          	 
	 	 	 
	 	
            By:

          	 
	 	 	
            Name:

          	 
	 	 	
            Title:

          	 


    

    

    

    

    
      
        
          [Shareholder Signature Page to Registration Rights Agreement]

        

      

      
        


      

    

    	 	
            BIOTECHNOLOGY VALUE TRADING FUND OS, L.P.

          	 
	 	 	 
	 	
            By:

          	 
	 	 	
            Name:

          	 
	 	 	
            Title:

          	 


    

    

    

    

    
      
        
          [Shareholder Signature Page to Registration Rights Agreement]

        

      

      
        


      

    

    	 	
            RA CAPITAL HEALTHCARE FUND, L.P

          	 
	 	 	 
	 	
            By:

          	 
	 	 	
            Name:

          	 
	 	 	
            Title:

          	 


    

    

    

    

    
      
        
          [Shareholder Signature Page to Registration Rights Agreement]

        

      

      
        


      

    

    	 	
            RA CAPITAL NEXUS FUND II, L.P

          	 
	 	 	 
	 	
            By:

          	 
	 	 	
            Name:

          	 
	 	 	
            Title:

          	 


    

    

    

    

    
      
        
          [Shareholder Signature Page to Registration Rights Agreement]

        

      

      
        


      

    

    	 	
            RTW MASTER FUND, LTD.

          	 
	 	 	 
	 	
            By:

          	 
	 	 	
            Name:

          	 
	 	 	
            Title:

          	 


    

    

    

    

    
      
        
          [Shareholder Signature Page to Registration Rights Agreement]

        

      

      
        


      

    

    	 	
            RTW INNOVATION MASTER FUND, LTD.

          	 
	 	 	 
	 	
            By:

          	 
	 	 	
            Name:

          	 
	 	 	
            Title:

          	 


    

    

    

    

    
      
        
          [Shareholder Signature Page to Registration Rights Agreement]

        

      

      
        


      

    

    	 	
            RTW VENTURE FUND LIMITED

          	 
	 	 	 
	 	
            By:

          	 
	 	 	
            Name:

          	 
	 	 	
            Title:

          	 


    

    

    

    

    
      
        
          [Shareholder Signature Page to Registration Rights Agreement]

        

      

      
        


      

    

    	 	
            THE BIOTECH GROWTH TRUST PLC

          	 
	 	 	 
	 	
            By:

          	 
	 	 	
            Name:

          	 
	 	 	
            Title:

          	 


    

    

    

    

    
      
        
          [Shareholder Signature Page to Registration Rights Agreement]

        

      

      
        


      

    

    	 	
            CORMORANT PRIVATE HEALTHCARE FUND III, LP

          	 
	 	 	 
	 	
            By:

          	 
	 	 	
            Name:

          	 
	 	 	
            Title:

          	 


    

    

    

    

    
      
        
          [Shareholder Signature Page to Registration Rights Agreement]

        

      

      
        


      

    

    	 	
            CORMORANT GLOBAL HEALTHCARE MASTER FUND, LP

          	 
	 	 	 
	 	
            By:

          	 
	 	 	
            Name:

          	 
	 	 	
            Title:

          	 


    

    

    

    

    
      
        
          [Shareholder Signature Page to Registration Rights Agreement]

        

      

      
        


      

    

    	 	
            CRMA SPV, L.P.

          	 
	 	 	 
	 	
            By:

          	 
	 	 	
            Name:

          	 
	 	 	
            Title:

          	 


    

    

    

    

    
      
        
          [Shareholder Signature Page to Registration Rights Agreement]

        

      

      
        


      

    

    	 	
            VENROCK HEALTHCARE CAPITAL PARTNERS EG, L.P.

          	 
	 	 	 
	 	
            By:

          	 
	 	 	
            Name:

          	 
	 	 	
            Title:

          	 


    

    

    

    

    
      
        
          [Shareholder Signature Page to Registration Rights Agreement]

        

      

      
        


      

    

    	 	
            VENROCK HEALTHCARE CAPITAL PARTNERS III, L.P.

          	 
	 	 	 
	 	
            By:

          	 
	 	 	
            Name:

          	 
	 	 	
            Title:

          	 


    

    

    

    

    
      
        
          [Shareholder Signature Page to Registration Rights Agreement]

        

      

      
        


      

    

    	 	
            VHCP CO-INVESTMENT HOLDINGS III, LLC

          	 
	 	 	 
	 	
            By:

          	 
	 	 	
            Name:

          	 
	 	 	
            Title:

          	 


    

    

    

    

    
      
        
          [Shareholder Signature Page to Registration Rights Agreement]

        

      

      
        


      

    

    	 	
            BOXER CAPITAL, LLC

          	 
	 	 	 
	 	
            By:

          	 
	 	 	
            Name:

          	 
	 	 	
            Title:

          	 


    

    

    

    

    
      
        
          [Shareholder Signature Page to Registration Rights Agreement]

        

      

      
        


      

    

    	 	
            MVA INVESTORS, LLC

          	 
	 	 	 
	 	
            By:

          	 
	 	 	
            Name:

          	 
	 	 	
            Title:

          	 


    

    

    

    

    
      
        
          [Shareholder Signature Page to Registration Rights Agreement]

        

      

      
        


      

    

    	 	
            CITADEL MULTI- STRATEGY EQUITIES (IRELAND) DESIGNATED ACTIVITY COMPANY

          	 
	 	 	 
	 	
            By:

          	 
	 	 	
            Name:

          	 
	 	 	
            Title:

          	 


    

    

    

    

    
      
        
          [Shareholder Signature Page to Registration Rights Agreement]

        

      

      
        


      

    

    	 	
            DEERFIELD PARTNERS, L.P.

          	 
	 	 	 
	 	
            By:

          	 
	 	 	
            Name:

          	 
	 	 	
            Title:

          	 


    

    

    

    

    
      
        
          [Shareholder Signature Page to Registration Rights Agreement]

        

      

      
        


      

    

    	 	
            ACUTA CAPITAL FUND, LP

          	 
	 	 	 
	 	
            By:

          	 
	 	 	
            Name:

          	 
	 	 	
            Title:

          	 


    

    

    

    

    
      
        
          [Shareholder Signature Page to Registration Rights Agreement]

        

      

      
        


      

    

    	 	
            ACUTA OPPORTUNITY FUND, LP

          	 
	 	 	 
	 	
            By:

          	 
	 	 	
            Name:

          	 
	 	 	
            Title:

          	 


    

    

    

    

    
      
        
          [Shareholder Signature Page to Registration Rights Agreement]

        

      

      
        


      

    

    	 	
            VERITION MULTI- STRATEGY MASTER FUND LTD.

          	 
	 	 	 
	 	
            By:

          	 
	 	 	
            Name:

          	 
	 	 	
            Title:

          	 


    

    

    

    

    
      
        
          [Shareholder Signature Page to Registration Rights Agreement]

        

      

      
        


      

    

    	 	
            GH CO-INVESTMENT LLC

          	 
	 	 	 
	 	
            By:

          	 
	 	 	
            Name:

          	 
	 	 	
            Title:

          	 


    

    

    

    

    
      
        
          [Shareholder Signature Page to Registration Rights Agreement]

        

      

      
        


      

    

    	 	
            THEIS TERWEY

          	 
	 	 	 
	 	
            By:

          	 
	 	 	
            Name:

          	 
	 	 	
            Title:

          	 


    

    

    
      
        
          [Shareholder Signature Page to Registration Rights Agreement]

        

      

      
        


      

    

    	 	
            MARKUS BREUER

          	 
	 	 	 
	 	
            By:

          	 
	 	 	
            Name:

          	 
	 	 	
            Title:

          	 


    

    

    

    

    
      
        
          [Shareholder Signature Page to Registration Rights Agreement]

        

      

      
        


      

    

    	 	
            CLAUS BO SVENDSEN

          	 
	 	 	 
	 	
            By:

          	 
	 	 	
            Name:

          	 
	 	 	
            Title:

          	 


    

    

    

    

    
      
        
          [Shareholder Signature Page to Registration Rights Agreement]

        

      

      
        


      

    

    	 	
            MAGNUS CLEMENSEN HALLE

          	 
	 	 	 
	 	
            By:

          	 
	 	 	
            Name:

          	 
	 	 	
            Title:

          	 


    

    

    

    

    
      
        
          [Shareholder Signature Page to Registration Rights Agreement]

        

      

      
        


      

    

    	 	
            DUNE CAPITAL

          	 
	 	 	 
	 	
            By:

          	 
	 	 	
            Name:

          	 
	 	 	
            Title:

          	 


    

    

    

    

    
      
        
          [Shareholder Signature Page to Registration Rights Agreement]

        

      

      
        


      

    

    	 	
            MICHAEL FORER

          	 
	 	 	 
	 	
            By:

          	 
	 	 	
            Name:

          	 
	 	 	
            Title:

          	 


    

    

    

    

    
      
        
          [Shareholder Signature Page to Registration Rights Agreement]

        

      

      
        


      

    

    

    

    Schedule A

    

    

    Florian Schönharting

    Dune Capital

    Inwood Settlement

    Biotechnology Value Fund L.P.

    Biotechnology Value Fund II, L.P.

    Biotechnology Value Trading Fund OS, L.P.

    RA CAPITAL HEALTHCARE FUND, L.P

    RA Capital NEXUS Fund II, L.P

    RTW MASTER FUND, LTD.

    RTW INNOVATION MASTER FUND, LTD.

    RTW VENTURE FUND LIMITED

    The Biotech Growth Trust Plc

    Cormorant Private Healthcare Fund III, LP

    Cormorant Global Healthcare Master Fund, LP

    CRMA SPV, L.P.

    Venrock Healthcare Capital Partners EG, L.P.

    Venrock Healthcare Capital Partners III, L.P.

    VHCP Co-Investment Holdings III, LLC

    Boxer Capital, LLC

    MVA Investors, LLC

    Citadel Multi- Strategy Equities (Ireland) Designated Activity Company

    Deerfield Partners, L.P.

    Acuta Capital Fund, LP

    Acuta Opportunity Fund, LP

    Verition Multi- Strategy Master Fund Ltd.

    GH Co-Investment LLC

    Theis Terwey

    Markus Breuer

    Claus Bo Svendsen

    Magnus Clemensen Halle

    Dune Capital

    Michael Forer

    

    

    
      


  

  
    
      [Shareholder Signature Page to Registration Rights Agreement]