exv4w18






Exhibit 4.18




          EIGHTH SUPPLEMENTAL INDENTURE (this “Supplemental Indenture”), dated as of March 1, 2010,
among LABORATORY SPECIALISTS OF AMERICA, INC., KROLL LABORATORY SPECIALISTS, INC., and SCIENTIFIC
TESTING LABORATORIES, INC. (the “New Guarantors”), Subsidiaries of Inverness Medical Innovations,
Inc. (or its successor) (the “Issuer”), INVERNESS MEDICAL INNOVATIONS, INC., a Delaware
corporation, each of the Guarantors (the “Existing Guarantors”) under the Indenture referred to
below, and THE BANK OF NEW YORK MELLON TRUST COMPANY, N.A., as Trustee under the Indenture referred
to below (the “Trustee”).




WITNESSETH:




          WHEREAS the Issuer has heretofore executed and delivered to the Trustee an Indenture dated as
of August 11, 2009, as amended, supplemented and modified by a First Supplemental Indenture dated
as of August 11, 2009, a Second Supplemental Indenture dated as of September 22, 2009, a Fourth
Supplemental Indenture dated as of November 25, 2009, and a Sixth Supplemental Indenture dated as
of February 1, 2010 (as so amended, supplemented or modified, and as further amended, supplemented
or modified to date, the “Indenture”), by and among the Issuer, the Existing Guarantors and the
Trustee, providing for the issuance of 7.875% Senior Notes due 2016 (the “Notes”);




          WHEREAS Section 4.13 of the Indenture provides that under certain circumstances the Issuer is
required to cause each of the New Guarantors to execute and deliver to the Trustee a supplemental
indenture pursuant to which each of the New Guarantors shall unconditionally and irrevocably
guarantee all of the Issuer’s obligations under the Notes pursuant to a guarantee on the terms and
conditions set forth herein; and




          WHEREAS pursuant to Section 9.01 of the Indenture, the Trustee, the Issuer and the Existing
Guarantors are authorized to execute and deliver this Supplemental Indenture;




          NOW THEREFORE, in consideration of the foregoing and for other good and valuable
consideration, the receipt of which is hereby acknowledged, each of the New Guarantors, the
Trustee, the Issuer and the Existing Guarantors mutually covenant and agree for the equal and
ratable benefit of the Holders as follows:




          SECTION 1. Definitions. For all purposes of this Supplemental Indenture, except as
otherwise herein expressly provided or unless the context otherwise requires: (i) the terms and
expressions used herein shall have the same meanings as corresponding terms and expressions used in
the Indenture; and (ii) the words “herein,” “hereof” and “hereby” and other words of similar import
used in this Supplemental Indenture refer to this Supplemental Indenture as a whole and not to any
particular section hereof.




          SECTION 2. Agreement to Guarantee. Each of the New Guarantors hereby unconditionally
and irrevocably agrees, jointly and severally with all other Guarantors, to guarantee the Issuer’s
obligations under the Notes and the Indenture on the terms and subject to the conditions set forth
in Article Ten of the Indenture and to be bound by all other applicable provisions of the
Indenture.




 









 





          SECTION 3. Ratification of Indenture; Supplemental Indenture Part of Indenture.
Except as expressly amended hereby, the Indenture is in all respects ratified and confirmed and all
the terms, conditions and provisions thereof shall remain in full force and effect. This
Supplemental Indenture shall form a part of the Indenture for all purposes, and every Holder
heretofore or hereafter authenticated and delivered shall be bound hereby.




          SECTION 4. Governing Law. This Supplemental Indenture shall be governed by, and
construed in accordance with, the laws of the State of New York, but without giving effect to
applicable principles of conflicts of laws to the extent that the application of the laws of
another jurisdiction would be required thereby.




          SECTION 5. Trustee Makes No Representation. The Trustee makes no representation as to
the validity or sufficiency of this Supplemental Indenture or for the recitals contained herein.




          SECTION 6. Counterparts. The parties may sign any number of copies of this
Supplemental Indenture. Each signed copy shall be an original, but all of them together represent
the same agreement.




          SECTION 7. Effect of Headings. The Section headings herein are for convenience only
and shall not effect the construction thereof.




[Signature Page Follows]




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          IN WITNESS WHEREOF, the parties hereto have caused this Supplemental Indenture to be duly
executed as of the date first above written.




	 	 	 	 	 	 	 	 	 
	 	 	NEW GUARANTORS:	 	 
	 

	 	 	 	 	 	 	 	 
	 	 	LABORATORY SPECIALISTS OF AMERICA,	 	 
	 	 	    INC.,	 	 
	 	 	    as a New Guarantor	 	 
	 
	 	 	 	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 
	 

	 	By:
	 	 	 	/s/ Jay McNamara	 	 
	 	 	 	 	 	 	 
	 

	 	 	 	Name:
	 	Jay McNamara	 	 
	 

	 	 	 	Title:
	 	Assistant Secretary	 	 
	 
	 	 	 	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 
	 	 	KROLL LABORATORY SPECIALISTS, INC.,	 	 
	 	 	    as a New Guarantor	 	 
	 
	 	 	 	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 
	 

	 	By:
	 	 	 	/s/ Jay McNamara	 	 
	 	 	 	 	 	 	 
	 

	 	 	 	Name:
	 	Jay McNamara	 	 
	 

	 	 	 	Title:
	 	Assistant Secretary	 	 
	 
	 	 	 	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 
	 	 	SCIENTIFIC TESTING LABORATORIES, INC.,
	 	 	    as a New Guarantor	 	 
	 
	 	 	 	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 
	 

	 	By:
	 	 	 	/s/ Jay McNamara	 	 
	 	 	 	 	 	 	 
	 

	 	 	 	Name:
	 	Jay McNamara	 	 
	 

	 	 	 	Title:
	 	Assistant Secretary	 	 






Signature Page to Eighth Supplemental Indenture (7.875% Notes — Public)




 









 





	 	 	 	 	 	 	 	 	 
	 	 	ISSUER:	 	 
	 
	 	 	 	 	 	 	 	 
	 	 	INVERNESS MEDICAL INNOVATIONS, INC.	 	 
	 
	 	 	 	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 
	 

	 	By:
	 	 	 	/s/ David A. Teitel	 	 
	 	 	 	 	 	 	 
	 

	 	 	 	Name:
	 	David A. Teitel	 	 
	 	 	 	 	Title:	 	Chief Financial Officer and Treasurer






Signature Page to Eighth Supplemental Indenture (7.875% Notes — Public)




 









 





	 	 	 	 	 	 	 	 	 
	 	 	EXISTING GUARANTORS:	 	 
	 

	 	 	 	 	 	 	 	 
	 	 	ALERE HEALTH, LLC	 	 
	 	 	ALERE HEALTHCARE OF ILLINOIS, INC.	 	 
	 	 	ALERE HEALTH IMPROVEMENT COMPANY
	 	 	ALERE HEALTH SYSTEMS, INC.	 	 
	 	 	ALERE MEDICAL, INC.	 	 
	 	 	ALERE WELLOLOGY, INC.	 	 
	 	 	ALERE WOMEN’S AND CHILDREN’S	 	 
	 	 	    HEALTH, LLC	 	 
	 	 	AMEDITECH INC.	 	 
	 	 	APPLIED BIOTECH, INC.	 	 
	 	 	BINAX, INC.	 	 
	 	 	BIOSITE INCORPORATED	 	 
	 	 	CHOLESTECH CORPORATION	 	 
	 	 	FIRST CHECK DIAGNOSTICS CORP.	 	 
	 	 	FIRST CHECK ECOM, INC.	 	 
	 	 	FREE & CLEAR, INC.	 	 
	 	 	GENECARE MEDICAL GENETICS CENTER,	 	 
	 	 	    INC.	 	 
	 	 	HEMOSENSE, INC.	 	 
	 	 	IM US HOLDINGS, LLC	 	 
	 

	 	 	 	 	 	 	 	 
	 

	 	 	 	 	 	 	 	 
	 	 	By:	 	 	 	/s/ David A. Teitel
	 	 	 	 	 	 	 
	 	 	 	 	Name: David A. Teitel	 	 
	 	 	 	 	Title (respectively): Vice President and
	 	 	 	 	 	 	Treasurer; Vice President, Finance; Vice
	 	 	 	 	 	 	President, Finance; Vice President and
	 	 	 	 	 	 	Treasurer; Vice President and Treasurer;
	 	 	 	 	 	 	Vice President, Finance; Vice President,
	 	 	 	 	 	 	Finance; General Manager; Vice
	 	 	 	 	 	 	President; Vice President, Finance; Vice
	 	 	 	 	 	 	President, Finance; Vice President,
	 	 	 	 	 	 	Finance and Chief Financial Officer;
	 	 	 	 	 	 	Vice President, Finance; Vice President;
	 	 	 	 	 	 	Vice President, Finance and Treasurer;
	 	 	 	 	 	 	Vice President and Treasurer; Treasurer;
	 	 	 	 	 	 	President






Signature Page to Eighth Supplemental Indenture (7.875% Notes — Public)




 









 





	 	 	 	 	 	 	 	 	 
	 	 	EXISTING GUARANTORS (continued):	 	 
	 

	 	 	 	 	 	 	 	 
	 	 	INNOVACON, INC.	 	 
	 	 	INNOVATIVE MOBILITY, LLC	 	 
	 	 	INSTANT TECHNOLOGIES, INC.	 	 
	 	 	INVERNESS MEDICAL, LLC	 	 
	 	 	INVERNESS MEDICAL — BIOSTAR INC.	 	 
	 	 	INVERNESS MEDICAL INNOVATIONS	 	 
	 	 	    NORTH AMERICA, INC.	 	 
	 	 	INVERNESS MEDICAL INTERNATIONAL	 	 
	 	 	    HOLDING CORP.	 	 
	 	 	ISCHEMIA TECHNOLOGIES, INC.	 	 
	 	 	IVC INDUSTRIES, INC.	 	 
	 	 	MATRITECH, INC.	 	 
	 	 	OSTEX INTERNATIONAL, INC.	 	 
	 	 	QUALITY ASSURED SERVICES, INC.	 	 
	 	 	REDWOOD TOXICOLOGY LABORATORY,	 	 
	 	 	    INC.	 	 
	 	 	RMD NETWORKS, INC.	 	 
	 	 	RTL HOLDINGS, INC.	 	 
	 	 	SELFCARE TECHNOLOGY, INC.	 	 
	 	 	TAPESTRY MEDICAL, INC.	 	 
	 	 	WAMPOLE LABORATORIES, LLC	 	 
	 	 	ZYCARE, INC.	 	 
	 

	 	 	 	 	 	 	 	 
	 

	 	 	 	 	 	 	 	 
	 	 	By:	 	 	 	/s/ David A. Teitel
	 	 	 	 	 	 	 
	 	 	 	 	Name: David A. Teitel	 	 
	 	 	 	 	Title (respectively): Vice President, Finance;
	 	 	 	 	 	 	Chief Financial Officer; Vice President,
	 	 	 	 	 	 	Finance; Vice President, Finance; Vice
	 	 	 	 	 	 	President, Finance; Vice President,
	 	 	 	 	 	 	Finance; President; Vice President,
	 	 	 	 	 	 	Finance; Vice President; Vice President,
	 	 	 	 	 	 	Finance; Vice President, Finance; Chief
	 	 	 	 	 	 	Financial Officer; Vice President,
	 	 	 	 	 	 	Finance; Vice President, Finance and
	 	 	 	 	 	 	Treasurer; Vice President, Finance; Vice
	 	 	 	 	 	 	President, Finance; Vice President,
	 	 	 	 	 	 	Finance; Vice President; Chief Financial
	 	 	 	 	 	 	Officer and Treasurer






Signature Page to Eighth Supplemental Indenture (7.875% Notes — Public)




 









 





	 	 	 	 	 	 	 	 	 
	 	 	EXISTING GUARANTORS (continued):	 	 
	 

	 	 	 	 	 	 	 	 
	 	 	MATRIA OF NEW YORK, INC.	 	 
	 
	 	 	 	 	 	 	 	 
	 

	 	 	 	 	 	 	 	 
	 

	 	By:
	 	 	 	/s/ Tom Underwood	 	 
	 	 	 	 	 	 	 
	 

	 	 	 	Name:
	 	Tom Underwood	 	 
	 

	 	 	 	Title:
	 	President	 	 






Signature Page to Eighth Supplemental Indenture (7.875% Notes — Public)




 









 





	 	 	 	 	 	 	 	 	 
	 	 	TRUSTEE:	 	 
	 

	 	 	 	 	 	 	 	 
	 	 	THE BANK OF NEW YORK MELLON TRUST
	 	 	    COMPANY, N.A.,	 	 
	 	 	    as Trustee	 	 
	 
	 	 	 	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 
	 	 	By:	 	/s/ Peter M. Murphy	 	 
	 	 	 	 	 	 	 
	 	 	 	 	Name: Peter  Murphy	 	 
	 	 	 	 	Its: Vice President	 	 






Signature Page to Eighth Supplemental Indenture (7.875% Notes — Public)