EX-10.13





 Exhibit 10.13 

[***] Certain information in this document has been omitted from this exhibit pursuant to Item 601(b) of Regulation
S-K because it is both not material and is the type that the Registrant treats as private or confidential. 

AMENDMENT No 1 
 TO THE

 EXCLUSIVE LICENSE AGREEMENT EFFECTIVE THE 7TH DAY OF DECEMBER 2020 

BETWEEN 
 STANFORD
UNIVERSITY 
 AND 

GRAPHITE BIO, INC. 
 Effective the 4th day
of March 2021, THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (“Stanford”), an institution of higher education having powers under the laws of the State of California, and Graphite Bio, Inc. (“Graphite”), a
Delaware corporation having a principal place of business at 279 East Grand Ave., South San Francisco, CA 94080, agree as follows: 
  

	1.	 BACKGROUND 



Stanford and Graphite are parties to an Exclusive License Agreement effective the 7th day of December 2020 (“Original Agreement”) covering modified
guide RNAs for [***] disclosed in Stanford docket [***], from the laboratory of Professor Matthew Porteus. 
 Stanford and Graphite wish to amend the
Original Agreement to change the date on which Graphite will issue equity to the inventors or their heirs according to the inventor list that Stanford will provide prior to issuance. 

 

	2.	 AMENDMENT 


  

	2.1	 Paragraph 7.2 of Original Agreement is hereby deleted in its entirety and replaced with the following:



 “7.2 Equity Interest. As further consideration, Graphite will grant to Stanford (or its designees as
provided below) an aggregate of 1,080,262 shares of common stock in Graphite. When issued, those shares will represent [***]% of the common stock in Graphite on a Fully-Diluted Basis as of the closing of the first tranche of Graphite’s Series A
preferred stock financing and as reflected in the pro forma capitalization table set forth in Exhibit B. Within [***] unless requested earlier in writing by Stanford, Graphite will provide Stanford with its current capitalization table and the
[***]. Graphite will provide Stanford with the [***]. On the 4-month anniversary of the Effective Date, but not before, Graphite will issue [***]% of all shares committed to Stanford pursuant to this
Section 7.2 and Section 7.3 below directly to and in the name of the inventors or their heirs according to the inventor list that Stanford will provide prior to issuance.” 












  

	2.2	 Paragraph 7.3 of Original Agreement is hereby deleted in its entirety and replaced with the following:



 “7.3 Anti-Dilution Protection. Graphite will issue Stanford (or its designees), without further
consideration, an aggregate of 478,325 additional shares of common stock in Graphite based on the closing of the second tranche of the Series A preferred stock financing of Graphite, which occurred on December 28, 2020, which maintains Stanford
at [***]% of the common shares of Graphite issued and outstanding on a Fully-Diluted Basis as of such closing. The Anti-Dilution Protection under this Section 7.3 will continue until an amount of $[***], when aggregated with prior closings, has
been raised by Graphite in a bona fide round of financing through the sale of securities or by conversion of instruments convertible into equity (“Dilution Trigger”). If the Dilution Trigger is reached or exceeded during a specific
round of funding, Anti-Dilution Protection will extend to the total amount of funding raised through the Dilution Trigger only and shall not apply to any amounts raised by Graphite in such round of funding in excess of the Dilution Trigger.”

  

	3.	 OTHER TERMS 


  

	3.1	 All other terms of the Original Agreement remain in full force and effect. 



 

	3.2	 The parties to this document agree that a copy of the original signature (including an electronic copy) may be
used for any and all purposes for which the original signature may have been used. The parties further waive any right to challenge the admissibility or authenticity of this document in a court of law based solely on the absence of an original
signature. 


 The parties execute this Amendment No 1 by their duly authorized officers or representatives. 

 

			
	THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
		
	Signature:	 	 /s/ Mona Wan

	    Name:	 	Mona Wan
	      Title:	 	Associate Director
	    Date:	 	3/4/2021


  

			
	GRAPHITE BIO, INC.
		
	Signature:	 	 /s/ Josh Lehrer

	    Name:	 	Josh Lehrer
	      Title:	 	Chief Executive Officer
	    Date:	 	3/4/2021



  
  

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