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# EXHIBIT 12.1

# Certification of
Principal Executive Officer pursuant to 17 CFR 240.13a-14(a), as adopted pursuant to
§302 of the Sarbanes-Oxley Act

I, Izhak Tamir certify
that:

| | 1. | I
have reviewed this annual report on Form 20-F of Tikcro Technologies Ltd.:
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| | 2. | Based
on my knowledge, this report does not contain any untrue statement of a
               material fact or omit to state a material fact necessary to make the
statements                made, in light of the circumstances under which such statements
were made, not                misleading with respect to the period covered by this
report;
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| | 3. | Based
on my knowledge, the financial statements, and other financial information
               included in this report, fairly present in all material respects the
financial                condition, results of operations and cash flows of the company
as of, and for,                the periods presented in this report;
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| | 4. | I
am responsible for establishing and maintaining disclosure controls and
               procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) for
the                company and have:
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| | a. | designed
such disclosure controls and procedures, or caused such disclosure           controls and
procedures to be designed under my supervision, to ensure that           material
information relating to the company, including its consolidated           subsidiaries,
is made known to me by others within those entities, particularly           during the
period in which this report is being prepared;
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| | b. | evaluated
the effectiveness of the companys disclosure controls and           procedures and
presented in this report my conclusions about the effectiveness           of the
disclosure controls and procedures, as of the end of the period covered           by this
report based on such evaluation; and
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| | c. | disclosed
in this report any change in the companys internal control over           financial
reporting that occurred during the period covered by the annual report           that has
materially affected, or is reasonably likely to materially affect, the           companys
internal control over financial reporting; and
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| | 5. | I
have disclosed, based on our most recent evaluation of internal control over
               financial reporting, to the companys auditors and the audit
committee of                the companys board of directors (or persons performing
the equivalent                functions):
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| | a. | all
significant deficiencies and material weaknesses in the design or operation           of
internal control over financial reporting which are reasonably likely to
          adversely affect the companys ability to record, process, summarize and
          report financial information; and
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| | b. | any
fraud, whether or not material, that involves management or other employees           who
have a significant role in the companys internal control over           financial
reporting.
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|Dated: June 25, 2006 |  | /s/  Izhak Tamir
Izhak TamirPrincipal Executive Officer andPrincipal Financial Officer
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