EXHIBIT 10.25

                             FIFTH ADDENDUM TO LEASE


This Fifth  Addendum To Lease is made and entered into the 30th day of November,
1996,   between  Conifer  Prince  Street   Associates   (Landlord)  and  Patient
Infosystems, Inc. formerly DSMI Corporation (Tenant).


WITNESSETH:  that Tenant  currently  leases and  occupies  approximately  13,117
square  feet of office  space at 46 Prince  Street,  Rochester,  New York  14607
pursuant to a Lease Agreement and First,  Second,  Third and Fourth Addendums To
Lease,  dated February 22, 1995;  August 18, 1995;  November 17, 1995; March 28,
1996 and October 29, 1996 respectively.


WHEREAS,  Tenant and Landlord desire to terminate it lease obligation  regarding
the space leased on the lower level of the Building  thereby reducing the amount
of square footage and corresponding its rental obligation  effective December 1,
1996.


NOW,  THEREFORE,  it is mutually  agreed  upon by Landlord  and Tenant to modify
certain provisions of the Lease as follows:


1. Effective  December 1, 1996,  Tenant's lease premises shall be  approximately
11,397 rentable square feet.


2.  Effective  December 1, 1996,  Tenant shall no longer be obligated  for costs
associated  with  space  previously  leased by Tenant on the lower  level of the
Building,  consisting of approximately 1,720 square feet. However,  Tenant shall
remain  responsible  for all appropriate  charges  incurred prior to December 1,
1996.


3. Effective  December 1, 1996, Tenant agrees to pay, Base Rent for space leased
on  the  first,  third  and  fourth  levels  of  the  Building,   consisting  of
approximately 11,397 square feet as following:

                       Period                        $/Sq.ft.           Monthly
                  Month-to-Month                     Base Rent         Base Rent
                  12/1/96-2/28/97                     $13.00          $12,346.75
                  3/1/97-2/28/98                      $13.50          $12,821.63
                  3/1/98-2/28/99                      $14.00          $13,296.50
                  3/1/99-11/30/99                     $14.50          $13,771.38


4.  Effective  December 1, 1996,  Schedule  A-5 shall  replace  Schedule A-4 and
Tenant's pro rata share of taxes, utilities and insurance will be 37.5%.


Except as modified above,  all other terms and conditions of the Lease Agreement
and First, Second, Third and Fourth Addendums To Lease, dated February 22, 1995;
August 18,  1995;  November  17,  1995;  March 28,  1996 and  October  29,  1996
respectively, shall remain unchanged and in full force and effect.

Agreed to by:                                        Agreed to by:
PATIENT INFOSYSTEMS, INC.           CONIFER PRINCE STREET ASSOCIATES
formerly DSMI CORPORATION



By:  /s/ Gregory D. Brown                   By:  /s/ Thomas L. Fountain        
Date:  November 30, 1996                    Date:  November 26, 1996          

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                                  SCHEDULE A-4

                             COMMON AREA MAINTENANCE

                                 ADDITIONAL RENT

                                    UTILITIES

                     Total Square Footage of Building 30,375

                     Square Footage Covered by Lease 11,397

                          Tenant's Share Electric 37.5%

                                 ADDITIONAL RENT

Heating and Air Conditioning

The heat pump units serving the leased premises shall be individually gauged and
the monthly charges shall be calculated as set forth on the attached and further
explained as follows:

1. The heat pump units serving the lease  premises  shall be identified by model
number.

2. The actual heat pump operating  hours will be recorded for each month (column
3) and  multiplied  by the energy use factor  (column 4)  applicable to the heat
pump model to establish the total energy units (column 5).

3. The  total  energy  units  for all  heat  pumps  is then  added to the  total
auxiliary  usage to establish  the grand total usage and energy cost (total KWH)
for the building.

4. The grand total usage and energy cost is multiplied by the utility  company's
rate per KWH to establish the total cost for kilowatt hours.

5. The total  KWH are  divided  by the total  heat  pump  usage and  charges  to
establish the heat pump hourly rate (column 6).

6. The monthly  tenant  charge is the heat pump hourly  rate  multiplied  by the
total energy units (column 5).

7. Tenant will also pay 37.5% of general usage/common area electric.

                                 ADDITIONAL RENT

                      Real Estate and Insurance Escalation

In  addition  to the  rents  set  forth in the  Lease,  and  heretofore  in this
Schedule,  with 1995 as the base year, Tenant shall pay 37.5% of the increase in
real  estate  taxes and other  government  levies in lieu of taxes  (payable  in
October of the  following  year),  and 37.5% of the  increase  in  property  and
liability insurance premiums (payable in February of the following year).