EX-4.1





 Exhibit 4.1 

AMENDED AND RESTATED 

CERTIFICATE OF INCORPORATION 

OF 
 LYELL IMMUNOPHARMA,
INC. 
 Lyell Immunopharma, Inc., a corporation organized and existing under and by virtue of the General Corporation Law of the State
of the Delaware (the “DGCL”), hereby certifies that: 
 ONE: The name of this corporation is Lyell
Immunopharma, Inc. The date of filing the original Certificate of Incorporation of this corporation with the Secretary of State of the State of Delaware (the “Secretary”) was June 29, 2018. 

TWO: The Amended and Restated Certificate of Incorporation of this corporation, attached hereto as Exhibit A, is
incorporated herein by reference, and restates, integrates and further amends the provisions of the Amended and Restated Certificate of Incorporation of this corporation, as previously amended or supplemented. 

THREE: This Amended and Restated Certificate of Incorporation has been duly approved by the board of directors of this corporation.

 FOUR: This Amended and Restated Certificate of Incorporation was approved by the holders of the requisite number of shares of this
corporation in accordance with Sections 228, 242 and 245 of the DGCL. 
 The Corporation has caused this Amended and Restated Certificate of
Incorporation to be signed by its duly authorized officer on June 21, 2021. 
  

			
	LYELL IMMUNOPHARMA, INC.
		
	By:	 	 /s/ Elizabeth Homans

		 	Elizabeth Homans
		 	Chief Executive Officer



  
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 EXHIBIT A 

AMENDED AND RESTATED 

CERTIFICATE OF INCORPORATION 

OF 
 LYELL IMMUNOPHARMA,
INC. 
 I. 
 The
name of the corporation is LYELL IMMUNOPHARMA, INC. (the “Corporation”). 

II. 
 The address of the
registered office of the Corporation in the State of Delaware is 3500 South Dupont Highway, City of Dover, County of Kent, Delaware 19901, and the name of the registered agent of the Corporation in the State of Delaware at such address is
Incorporating Services, Ltd. 
 III. 

The purpose of the Corporation is to engage in any lawful act or activity for which a corporation may be organized under the General
Corporation Law of the State of Delaware (the “DGCL”). 
 IV. 

A. The Corporation is authorized to issue two classes of stock to be designated, respectively, “Common Stock”
and “Preferred Stock.” The total number of shares that the Corporation is authorized to issue is 510,000,000 shares. Of such shares, 500,000,000 shares shall be Common Stock, each having a par value of $0.0001 and
10,000,000 shares shall be Preferred Stock, each having a par value of $0.0001. 
 B. The Preferred Stock may be issued from time to
time in one or more series. The board of directors of the Corporation (the “Board of Directors”) is hereby expressly authorized to provide for the issue of all or any of the shares of the Preferred Stock in one or more
series, and to fix the number of shares for each such series and to determine or alter for each such series, such voting powers, full or limited, or no voting powers, and such designation, preferences, and relative, participating, optional, or other
rights and such qualifications, limitations, or restrictions thereof, as shall be stated and expressed in the resolution or resolutions adopted by the Board of Directors providing for the issuance of such shares and as may be permitted by the DGCL.
The Board of Directors is also expressly authorized to increase or decrease the number of shares of any series subsequent to the issuance of shares of that series, but not below the number of shares of such series then outstanding and not by more
than the number of remaining authorized but undesignated shares of Preferred Stock. In case the number of shares of any series shall be decreased in accordance with the foregoing sentence, the shares constituting such decrease shall resume the
status that they had prior to the adoption of the resolution originally fixing the number of shares of such series. The number of authorized shares of Preferred Stock, or any series thereof, may be increased or decreased (but not below the number of
shares thereof then outstanding) by the affirmative vote of the holders of a majority of the voting power of the outstanding shares of stock of the Corporation entitled to vote thereon, without a separate vote of the holders of the Preferred Stock,
or of any series thereof irrespective of Section 242(b)(2) of the DGCL, unless a vote of any such holders is required pursuant to the terms of any certificate of designation filed with respect to any series of Preferred Stock. 

  
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 C. Each outstanding share of Common Stock shall entitle the holder thereof to one
vote on each matter properly submitted to the stockholders of the Corporation for their vote; provided, however, that, except as otherwise required by law, holders of Common Stock shall not be entitled to vote on any amendment to this Amended and
Restated Certificate of Incorporation (including any certificate of designation filed with respect to any series of Preferred Stock) that relates solely to the terms of one or more outstanding series of Preferred Stock if the holders of such
affected series are entitled, either separately or together as a class with the holders of one or more other such series, to vote thereon by law or pursuant to this Amended and Restated Certificate of Incorporation (including any certificate of
designation filed with respect to any series of Preferred Stock). 
 V. 

For the management of the business and for the conduct of the affairs of the Corporation, and in further definition, limitation and regulation
of the powers of the Corporation, of its directors and of its stockholders or any class thereof, as the case may be, it is further provided that: 

A. MANAGEMENT OF BUSINESS. 

The management of the business and the conduct of the affairs of the Corporation shall be vested in its Board of Directors. Subject to any
rights of the holders of shares of any series of Preferred Stock then outstanding to elect additional directors under specified circumstances, the number of directors that shall constitute the Board of Directors shall be fixed exclusively by
resolutions adopted by a majority of the authorized number of directors constituting the Board of Directors. 
 B. BOARD
OF DIRECTORS. 
 Subject to the rights of the holders of any series of Preferred Stock to elect additional
directors under specified circumstances, following the closing of the initial public offering pursuant to an effective registration statement under the Securities Act of 1933, as amended (the “1933 Act”), covering the offer
and sale of Common Stock to the public (the “Initial Public Offering”), the directors shall be divided into three classes designated as Class I, Class II and Class III, respectively. Each class will consist, as
nearly as possible, of a number of directors equal to one-third of the number of members of the Board of Directors authorized as provided in Section A of this Article V. The Board of Directors is authorized to
assign members of the Board of Directors already in office to such classes at the time the classification becomes effective. At the first annual meeting of stockholders following the closing of the Initial Public Offering, the initial term of office
of the Class I directors shall expire and Class I directors shall be elected for a full term of three years. At the second annual meeting of stockholders following the closing of the Initial Public Offering, the initial term of office of
the Class II directors shall expire and Class II directors shall be elected for a full term of three years. At the third annual meeting of stockholders following the closing of the Initial Public Offering, the initial term of office of the
Class III directors shall expire and Class III directors shall be elected for a full term of three years. At each succeeding annual meeting of stockholders, directors shall be elected for a full term of three years to succeed the directors
of the class whose terms expire at such annual meeting. Notwithstanding the foregoing provisions of this section, each director shall serve until his or her successor is duly elected and qualified or until his or her earlier death, resignation or
removal. No decrease in the number of directors constituting the Board of Directors shall shorten the term of any incumbent director. 

  
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 C. REMOVAL OF DIRECTORS. 

Subject to the rights of any series of Preferred Stock to elect additional directors under specified circumstances, neither the Board of
Directors nor any individual director may be removed from office without cause. Subject to the rights of any series of Preferred Stock to remove directors elected by the holders of such series of Preferred Stock and any limitation imposed by
applicable law, any individual director or the entire Board of Directors may be removed from office with cause by the affirmative vote of the holders of at least 66 2/3% of the voting power of all then outstanding shares of capital stock of the
Corporation entitled to vote on the election of such directors. 
 D. VACANCIES. 

Subject to any limitations imposed by applicable law and subject to the rights of the holders of any series of Preferred Stock to elect
additional directors or fill vacancies in respect of such directors, any vacancies on the Board of Directors resulting from death, resignation, disqualification, removal or other causes and any newly created directorships resulting from any increase
in the number of directors, shall, unless the Board of Directors determines by resolution that any such vacancies or newly created directorships shall be filled by the stockholders and except as otherwise provided by applicable law, be filled only
by the affirmative vote of a majority of the directors then in office, even though less than a quorum of the Board of Directors or by the sole remaining director, and not by the stockholders. Any director elected in accordance with the preceding
sentence shall hold office for the remainder of the full term of the director for which the vacancy was created or occurred and until such director’s successor shall have been elected and qualified or until such director’s earlier death,
resignation or removal. 
 E. BYLAW AMENDMENTS. 

The Board of Directors is expressly authorized and empowered to adopt, amend or repeal the Bylaws of the Corporation or any provision or
provisions thereof. Any adoption, amendment or repeal of the Bylaws of the Corporation or any provision or provisions thereof by the Board of Directors shall require the approval of a majority of the authorized number of directors. The
stockholders shall also have power to adopt, amend or repeal the Bylaws of the Corporation; provided, however, that, in addition to any vote of the holders of any class or series of stock of the Corporation required by law, such action by
stockholders shall require the affirmative vote of the holders of at least 66 2/3% of the voting power of all of the then-outstanding shares of the capital stock of the Corporation entitled to vote generally in the election of directors, voting
together as a single class. 
 F. STOCKHOLDER ACTIONS. 

1. The directors of the Corporation need not be elected by written ballot unless the Bylaws so provide. 

2. No action shall be taken by the stockholders of the Corporation except at an annual or special meeting of stockholders called in
accordance with the Bylaws, and no action shall be taken by the stockholders by written consent or electronic transmission. 
 3.
Advance notice of stockholder nominations for the election of directors and of business to be brought by stockholders before any meeting of the stockholders of the Corporation shall be given in the manner provided in the Bylaws of the Corporation.

 VI. 
 A. The
liability of the directors for monetary damages shall be eliminated to the fullest extent under applicable law. 

  
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 B. To the fullest extent permitted by applicable law, the Corporation is authorized
to provide indemnification of (and advancement of expenses to) directors, officers and agents of the Corporation (and any other persons to which applicable law permits the Corporation to provide indemnification) through Bylaw provisions, agreements
with such agents or other persons, vote of stockholders or disinterested directors or otherwise in excess of the indemnification and advancement otherwise permitted by such applicable law. If applicable law is amended after approval by the
stockholders of this Article VI to authorize corporate action further eliminating or limiting the personal liability of directors, then the liability of a director to the Company shall be eliminated or limited to the fullest extent permitted by
applicable law as so amended. 
 C. Any repeal or modification of this Article VI shall only be prospective and shall not affect
adversely the rights or protections or increase the liability of any officer or director under this Article VI as in effect at the time of the alleged occurrence of any act or omission to act giving rise to liability or indemnification. 

VII. 
 Unless the
Corporation consents in writing to the selection of an alternative forum, the Court of Chancery of the State of Delaware (or, if and only if the Court of Chancery of the State of Delaware lacks subject matter jurisdiction, any state court located
within the State of Delaware or, if and only if all such state courts lack subject matter jurisdiction, the federal district court for the District of Delaware) and any appellate court therefrom shall be the sole and exclusive forum for the
following claims or causes of action under Delaware statutory or common law: (A) any derivative claim or cause of action brought on behalf of the Corporation; (B) any claim or cause of action for breach of a fiduciary duty owed by any
current or former director, officer or other employee of the Corporation to the Corporation or the Corporation’s stockholders; (C) any claim or cause of action against the Corporation or any current or former director, officer or other
employee of the Corporation, arising out of or pursuant to any provision of the DGCL, this Amended and Restated Certificate of Incorporation or the Bylaws of the Corporation (as each may be amended from time to time); (D) any claim or cause of
action seeking to interpret, apply, enforce or determine the validity of this Amended and Restated Certificate of Incorporation or the Bylaws of the Corporation (as each may be amended from time to time, including any right, obligation or remedy
thereunder); (E) any claim or cause of action as to which the DGCL confers jurisdiction on the Court of Chancery of the State of Delaware; and (F) any claim or cause of action against the Corporation or any current or former director, officer
or other employee of the Corporation, governed by the internal-affairs doctrine or otherwise related to the corporation’s internal affairs, in all cases to the fullest extent permitted by law and subject to the court having personal
jurisdiction over the indispensable parties named as defendants. This Section A of Article VII shall not apply to claims or causes of action brought to enforce a duty or liability created by the 1933 Act or the Securities Exchange Act of 1934, as
amended, or any other claim for which the federal courts have exclusive jurisdiction. 
 Unless the Corporation consents in writing to the
selection of an alternative forum, to the fullest extent permitted by law, the federal district courts of the United States of America shall be the exclusive forum for the resolution of any complaint asserting a cause of action arising under the
1933 Act , including all causes of action asserted against any defendant named in such complaint. For the avoidance of doubt, this provision is intended to benefit and may be enforced by the corporation, its officers and directors, the underwriters
for any offering giving rise to such complaint, and any other professional entity whose profession gives authority to a statement made by that person or entity and who has prepared or certified any part of the documents underlying the offering. 


  
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 Any person or entity holding, owning or otherwise acquiring any interest in any security of
the Corporation shall be deemed to have notice of and consented to the provisions of this Amended and Restated Certificate of Incorporation. 

VIII. 
 A. The
Corporation reserves the right to amend, alter, change or repeal, at any time and from time to time, any provision contained in this Amended and Restated Certificate of Incorporation, in the manner now or hereafter prescribed by statute, except as
provided in paragraph B. of this Article VIII, and all rights, preferences and privileges of whatsoever nature conferred upon the stockholders, directors or any other persons whomsoever by and pursuant to this Amended and Restated Certificate
of Incorporation in its present form or as hereafter amended herein are granted subject to this reservation. 
 B. Notwithstanding any
other provisions of this Amended and Restated Certificate of Incorporation or any provision of applicable law which might otherwise permit a lesser vote or no vote, but in addition to any affirmative vote of the holders of any particular class or
series of capital stock of the Corporation required by law or by this Amended and Restated Certificate of Incorporation or any certificate of designation filed with respect to a series of Preferred Stock, the affirmative vote of the holders of at
least 66 2/3% of the voting power of all of the then outstanding shares of capital stock of the Corporation entitled to vote generally in the election of directors, voting together as a single class, shall be required to alter, amend or repeal
(whether by merger, consolidation or otherwise) Articles V, VI, VII and VIII. 
 * * * * 

  
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