Amended
and RESTATED
CERTIFICATE OF INCORPORATION
OF
MANHATTAN PHARMACEUTICALS, INC.



I, the Chief Executive
Officer, for purposes of amending and restating the Certificate of Incorporation of Manhattan Pharmaceuticals, Inc., a Delaware
corporation which was originally incorporated on May 18, 1993 under the name of Atlantic Pharmaceuticals, Inc. (the “Corporation”),
hereby certify as follows:



This Amended and Restated
Certificate of Incorporation (the “Certificate of Incorporation”) of the Corporation has been duly adopted in accordance
with the provisions of Sections 242 and 245 of the General Corporation Law of the State of Delaware.



The text of the Certificate
of Incorporation of the Corporation is hereby amended and restated to read in its entirety as follows:



FIRST: The name of the
corporation is



TG Therapeutics, Inc.



SECOND: The address of
the registered office of the Corporation in the State of Delaware is 1209 Orange Street, in the City of Wilmington, County of New
Castle, and the name of its registered agent at that address is The Corporation Trust Company.



THIRD: The purpose of
the Corporation is to engage in any lawful act or activity for which corporations may be organized under the General Corporation
Law of the State of Delaware.



FOURTH: A. The Corporation
is authorized to issue two classes of stock designated “Common Stock” and “Preferred Stock,” respectively.
The total number of shares of Common Stock authorized to be issued is 500,000,000, and each such share will have a par value of
$0.001. The total number of shares of Preferred Stock authorized to be issued is 10,000,000, and each such share will have a par
value of $0.001.



B. Effective 12:01 a.m.
on April 30, 2012 (the “Effective Time”) every fifty six and one quarter (56.25) shares of Common Stock of the Corporation
issued and outstanding immediately prior to the Effective Time (“Old Common Stock”) shall automatically be combined,
without any action on the part of the holder thereof, into one (1) share of fully paid and nonassessable Common Stock of the Corporation
(“New Common Stock”), subject to the treatment of fractional share interests described below.



C. Following the Effective
Time, each holder of Old Common Stock shall be entitled to receive upon surrender of such holder’s certificate(s) representing
Old Common Stock (whether one or more, “Old Certificates”) for cancellation pursuant to procedures adopted by the Corporation,
a certificate(s) representing the number of whole shares of New Common Stock (whether one or more, “New Certificates”)
into which and for which the shares of Old Common Stock formerly represented by such Old Certificates so surrendered are reclassified
under the terms hereof. From and after the Effective Time, until surrendered for exchange, each outstanding Old Certificate shall
be deemed for all purposes to represent (i) the whole number of shares of New Common Stock into which the Old Common Stock represented
by such Old Certificate shall be combined, and (ii) the right to receive New Certificates.



1









D. No fractional shares
of Common Stock of the Corporation shall be issued. No stockholder of the Corporation shall transfer any fractional shares of Common
Stock of the Corporation. The Corporation shall not recognize on its stock record books any purported transfer of any fractional
share of Common Stock of the Corporation. A holder of Old Certificates at the Effective Time who would otherwise be entitled to
a fraction of a share of New Common Stock shall, in lieu thereof, be entitled to round such fractional value up to the nearest
whole number and receive the additional share created thereby.



E. Shares of Preferred
Stock may be issued from time to time in one or more series. The Board of Directors is hereby authorized, by adopting appropriate
resolutions and causing one or more certificates of amendment to be signed, verified and delivered in accordance with the General
Corporation Law, to establish from time to time the number of shares to be included in such series, and to fix the designations,
relative rights, preferences and limitations of the shares of each such series. Such designations, relative rights, preferences
and limitations may include, but are not limited to, the fixing or alteration of the dividend rights, dividend rate, conversion
rights, exchange rights, voting rights, rights and terms of redemption (including sinking fund provisions), the redemption price
or prices, and the liquidation preferences of any wholly unissued series of shares of Preferred Stock, or any of them. In accordance
with the authority hereby granted, the Board of Directors may increase or decrease the number of shares of any series subsequent
to the issue of shares of that series, but not above the total number of authorized shares of Preferred Stock and not below the
number of shares of such series then outstanding. In case the number of shares of any series shall be so decreased, the shares
constituting such decrease shall resume the status that they had prior to the adoption of the resolution originally fixing the
number of shares of such series. Except as may otherwise be required by law or this Certificate of Incorporation, the terms of
any series of Preferred Stock may be amended without the consent of the holders of any other series of Preferred Stock, or Common
Stock.



F. The Certificate of
Designations, Preferences and Other Rights of Series A Preferred Stock, as filed with the Delaware Secretary of State on December
29, 2011, and the Amended Certificate of Designations, Preferences and Other Rights of Series A Preferred Stock, as filed with
the Delaware Secretary of State on January 27, 2012, are incorporated by reference into this Certificate of Incorporation and attached
hereto as Exhibit A and Exhibit B, respectively.



FIFTH: The number of
directors which shall constitute the whole Board of Directors shall be fixed by, or in the same manner provided in, the Bylaws
of the Corporation.



SIXTH: In furtherance
and not in limitation of the powers conferred by statute, the Board of Directors is expressly authorized to make, repeal, alter,
amend and rescind the Bylaws of the Corporation.



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SEVENTH: Election of
directors at an annual or special meeting of stockholders need not be made by written ballot unless the Bylaws of the Corporation
shall so provide.



EIGHTH: Whenever a compromise
or arrangement is proposed between the Corporation and its creditors or any class of them and/or between the Corporation and its
stockholders or any class of them, any court of equitable jurisdiction within the State of Delaware, may, on application in a summary
way of the Corporation or of any creditor or stockholder thereof on the application or any receiver or receiver” appointed
for the Corporation under the provisions of Section 29l of Title B of the Delaware code or on the application of the trustees in
dissolution or of any receiver or receivers appointed for the Corporation under the provisions of Section 279 of Title B of the
Delaware Code order a meeting of the creditors or class of creditors, and/or of the stockholders or a class of stockholders or
the Corporation, as the case may be to be summoned in such winner as the slid court directs. If a majority in number representing
three-fourths in value of the creditors or class of creditor., and/or of the stockholders or class of stockholders or class of
stockholders of the Corporation, as the case may be, agree to any compromise or arrangement and to any reorganization of the Corporation
as a consequence of such compromise or arrangement, the said compromise or arrangement and the said reorganization shall, if sanctioned
by the court to which the said application had been made, the binding on all the creditors or class of creditors, and/or on all
the stockholders or class of stockholders or class of stockholders, of the Corporation, as the case may be, and also on the Corporation.



NINTH: The personal liability
of directors of the Corporation is hereby eliminated to the fullest extent permitted by paragraph 7 of Subsection (b) of Section
102 of the General Corporation Law of the State of Delaware as the same may be amended and supplemented.



TENTH: The Corporation
shall, to the full extent permitted by Motion 145 of the Delaware General Corporation Law, as amended and supplemented from time
to time, indemnify all persons whom it may indemnify under said section from and against any and all of the expenses, liabilities,
or other matters referred to in or covered by said section, and the indemnification provided for herein shall not be deemed exclusive
of any other rights to which those indemnified may be entitled under any Bylaw, agreement, vote of stockholders, or disinterested
directors or otherwise, both as to action in his official capacity and as to action in another capacity while holding such office,
and shall continue as to a person who has ceased to be a director, officer, employee, or agent and shall inure to the benefit of
the heirs, executors, and administrators of such a person.



ELEVENTH: The Corporation
reserves the right to amend, alter, change or repeal any provision contained in this Certificate of Incorporation, in the manner
now or hereafter prescribed by statute, and all rights conferred on stockholders heroin are granted subject to this reservation.



IN WITNESS WHEREOF, the
undersigned being the Chief Executive Officer of the Corporation has duly executed this certificate in the name and on behalf of
Manhattan Pharmaceuticals, Inc., and affirms that the statements made herein are true under the penalty of perjury, this 26th
day of April, 2012.





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| | MANHATTAN PHARMACEUTICALS, INC.
| | -------------------------------
| |                                
| |                                
| |                                
| | By:                            
| |                                
| |                                















4









EXHIBIT
A









5









CERTIFICATE
OF DESIGNATIONS, PREFERENCES
AND OTHER RIGHTS OF
SERIES A PREFERRED STOCK
OF
TG THERAPEUTICS, INC.



Pursuant to Section 151 of the
General Corporation Law of the State of Delaware



TG Therapeutics, Inc.
(the “Corporation”), a corporation organized and existing under the General Corporation Law of the State of
Delaware (the “General Corporation Law”), hereby certifies that, pursuant to (i) the authority conferred upon
the board of directors (the “Board of Directors”) by the Certificate of Incorporation of the Corporation (the
“Certificate of Incorporation”) and (ii) the provisions of Section 151 of the General Corporation Law, the Board
of Directors duly adopted a resolution on December 28, 2011, which resolution is as follows:



RESOLVED, that pursuant
to the authority vested in the Board of Directors of the Corporation by the Certificate of Incorporation, the Board of Directors
does hereby create a series of the presently authorized shares of Preferred Stock of the Corporation. The shares of such series
shall be designated “Series A Preferred Stock” and shall have a par value of $0.001 per share. The designations,
preferences and other rights of Series A Preferred Stock authorized hereunder and the qualifications, limitations and restrictions
of such preferences and rights are as follows:



1.        Designation
and Number.



A series of Preferred
Stock of the Corporation, designated “Series A Preferred Stock,” is hereby established. The number of shares of Series
A Preferred Stock authorized shall be three million and five hundred thousand (3,500,000).



2.        Dividend
Provisions.



(a)        The Series
A Preferred Stock shall with respect to dividend rights rank senior to the Common Stock of the Corporation and any other series
of Preferred Stock established hereafter by the Board of Directors unless such series of Preferred Stock expressly ranks senior
to orpari passu with the Series A Preferred Stock (all of such series of Preferred Stock to which the Series A Preferred
Stock ranks senior, the “Junior Securities”).



(b)        The holders
of shares of Series A Preferred Stock shall be entitled to receive dividends, out of any assets legally available therefor, prior
and in preference to any declaration or payment of any dividend on Common Stock or any Junior Securities of the Corporation, payable
only when, as and if declared by the Board of Directors.



(c)        No dividend
or other distribution shall be paid on or declared and set apart for any share of Common Stock, Junior Securities or any other
securities of the Corporation entitled generally to participate in the earnings or assets of the Corporation, other than the Series
A Preferred Stock, for any period unless at the same time an equal dividend or distribution for the same period shall be paid on
or declared and set apart for each share of Series A Preferred Stock based on the number of shares of Common Stock into which each
share is then convertible (the “Conversion Shares”).



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3.        Liquidation
Preference.



(a)        In the
event of any liquidation, dissolution or winding up of the Corporation, either voluntary or involuntary (including without limitation
upon any bankruptcy), the holders of Series A Preferred Stock shall be entitled to receive in exchange for and in redemption of
each share of Series A Preferred Stock $20 per share on a pari passu basis, as adjusted for any stock splits, dividends
and the like, out of the proceeds of such liquidation, prior and in preference to any distribution to the holders of Common Stock
and Junior Securities by reason of their ownership thereof, from the funds, proceeds or assets of the Corporation legally available
for distribution to stockholders (the “Liquidation Preference”).



If upon the occurrence of a Liquidation
Event, as defined below, the assets, proceeds and funds thus distributed among the holders of the Series A Preferred Stock shall
be insufficient to permit the payment to such holders of their full Liquidation Preference, then the entire assets, proceeds and
funds of the Corporation legally available for distribution shall first be distributed ratably to the holders of Series A Preferred
Stock in accordance with the amount such holders of Series A Preferred Stock are entitled to receive under the provisions of this
Section 3.



(b)        Upon the
completion of the distributions required by Section 3(a), if assets remain in the Corporation, all of such assets available for
distribution to the stockholders shall be distributed among the holders of the Common Stock pro rata based upon the number of shares
of Common Stock held by them.



(c)        (i) For
purposes of this Section 3, unless otherwise agreed in writing by the holders of not less than a majority of the outstanding shares
of Series A Preferred Stock (voting together as a single class) (such required holders being sometimes collectively referred to
herein as the “Required Holders”), a liquidation, dissolution or winding up of the Corporation shall be deemed to be
occasioned by, or to include, (A) the acquisition of the Corporation by another entity by means of any transaction or series of
related transactions (including, without limitation, any reorganization, merger, share exchange or consolidation) that results
in the Corporation’s stockholders immediately prior to such transaction not holding, directly or indirectly, at least 50%
of the voting power of the surviving or continuing entity, or (B) a sale, conveyance or disposition of all or substantially all
of the assets of the Corporation unless the Corporation’s stockholders immediately prior to such transaction will, as a result
of such sale, conveyance or disposition hold at least 50% of the voting power of the purchasing entity (each such transaction and
any liquidation, dissolution or winding up of the Corporation, either voluntary or involuntary (including without limitation upon
any bankruptcy) is sometimes referred to herein as a “Liquidation Event”)). In the event of a Liquidation Event described
in the immediately preceding sentence involving the sale or exchange of shares by stockholders of the Corporation, the funds or
proceeds resulting from such transaction available to the Corporation, if any, and all other or assets legally available for distribution
to stockholders shall be deemed to have a fair market value for purposes of determining the entitlement to liquidating distributions
equal to the fair market value of the aggregate consideration to be paid to all selling stockholders in exchange for all or part
of any capital stock of the Corporation divided by a fraction, the numerator of which is the total number of shares of Common Stock
deemed to be sold pursuant to such liquidation and the denominator of which is the sum of the total number of shares of Common
Stock outstanding and the total number of shares of Common Stock issuable with respect to Common Stock Equivalents (as defined
below) immediately prior to such liquidation.



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(ii)        In any
Liquidation Event, if the consideration received is other than cash, its value will be deemed its fair market value. Any securities
shall be valued as follows:



(A)        Securities
not subject to investment letter or other similar restrictions on free marketability covered by (B) below:



(1)        If traded
on a securities exchange, the value shall be deemed to be the average of the closing prices of the securities on such exchange
over the thirty-day period ending three (3) days prior to the closing;



(2)        If actively
traded over-the-counter, the value shall be deemed to be the average of the closing bid or sale prices (whichever is applicable)
over the thirty-day period ending three (3) days prior to the closing; and



(3)        If there
is no active public market, the value shall be the fair market value thereof, as determined by the Board of Directors of the Corporation
and approved by the Required Holders.



(B)        The method
of valuation of securities subject to investment letter or other restrictions on free marketability (other than restrictions arising
solely by virtue of a stockholder’s status as an affiliate or former affiliate) shall be to make an appropriate discount
from the market value determined as above in (A) (1), (2) or (3) to reflect the approximate fair market value thereof, as determined
by the Board of Directors of the Corporation and approved by the Required Holders.



(iii)        The
Corporation shall give each holder of record of Series A Preferred Stock written notice of an impending Liquidation Event described
in Section 3(c)(i) not later than twenty (20) days prior to the stockholders’ meeting called to approve such Liquidation
Event, or twenty (20) days prior to the closing of such Liquidation Event, whichever is earlier, and shall also notify such holders
in writing of the final approval of such Liquidation Event, The first of such notices shall describe the material terms and conditions
of the impending Liquidation Event and the provisions of this Section 3, and the Corporation shall thereafter give such holders
prompt notice of any material changes. Such Liquidation Event shall in no event take place sooner than twenty (20) days after the
Corporation has given the first notice provided for herein or sooner than ten (10) days after the Corporation has given notice
of any material changes provided for herein; provided, however, that such periods may be shortened upon the written consent of
the Required Holders,



(iv)        In the
event the requirements of Section 3(c)(iii) are not complied with, the Corporation shall forthwith either:





8









(A)        cause
such closing to be postponed until such time as the requirements of Section 3(c)(iii) have been complied with; or



(B)        cancel
such Liquidation Event, in which event the rights, preferences and privileges of the holders of the Series A Preferred Stock shall
revert to and be the same as such rights, preferences and privileges existing immediately prior to the date of the first notice
referred to in Section 3(c)(iii) hereof.



4.        Conversion.
The holders of the Series A Preferred Stock shall have conversion rights (the “Conversion Rights”) as follows; provided,
however, that all such rights are subject to the amendment of the Corporation’s Certificate of Incorporation or a reverse
stock split, in either case to provide for sufficient authorized shares of the Corporation’s Common Stock to effect any such
conversion (the “Amendment”), and no such Conversion Rights shall exist until such Amendment has been properly approved
and filed with the Secretary of State of the State of Delaware :



(a)        Right
to Convert. Subject to adoption of the Amendment, each share of Series A Preferred Stock shall be convertible, at the option
of the holder thereof, at any time after the date of issuance of such shares, at the office of the Corporation or any transfer
agent for such stock, into Five Hundred (500) shares of fully paid and nonassessable shares of Common Stock.



(b)        Automatic
Conversion. Subject to the adoption of the Amendment, each share of Series A Preferred Stock shall automatically be converted
into Five Hundred (500) shares of fully paid and nonassessable Common Stock immediately upon the consummation of a merger (including
a reverse merger) or sale of substantially all of the assets of the Corporation. Each share of Series A Preferred Stock will automatically
convert into that number of shares of common stock of the surviving entity equal in value to the Liquidation Preference. Such conversion
shall be automatic, without need for any further action by the holders of shares of the Series A Preferred Stock and regardless
of whether the certificates representing such shares are surrendered to the Corporation or its transfer agent; provided, however,
that the Corporation shall not be obligated to issue certificates evidencing the shares of Common Stock issuable upon such conversion
unless certificates evidencing such shares of Series A Preferred Stock so converted are surrendered to the Corporation or the holder
of record of such shares notifies the Corporation that such certificates have been lost, stolen or destroyed and executes an agreement
to indemnify the Corporation from any loss incurred by it in connection with such certificates, in each case in accordance with
the procedures described in Section 4(c) below. Upon the conversion of any Series A Preferred Stock pursuant to this Section 4(b),
the Corporation shall promptly send written notice thereof, by registered or certified mail, return receipt requested and postage
prepaid, by hand delivery or by overnight delivery, to each holder of record of the Series A Preferred Stock at such holder’s
address then shown on the records of the Corporation, which notice shall state that certificates evidencing shares of Series A
Preferred Stock must be surrendered at the office of the Corporation (or of its transfer agent for the Common Stock, if applicable)
in the manner described in Section 4(c).



9









(c)        Mechanics
of Conversion. Before any holder of Series A Preferred Stock shall be entitled to receive certificates representing shares
of Common Stock into which shares of Series A Preferred Stock are converted pursuant to this Section 4, such holder shall surrender
the certificate or certificates therefor, duly endorsed, at the office of the Corporation or of any transfer agent selected by
the Corporation for the Series A Preferred Stock, and shall give written notice to the Corporation at such office of the name or
names in which the certificate or certificates for shares of Common Stock are to be issued. The Corporation shall, as soon as practicable
and in no event later than fifteen (15) days after the delivery of said certificates, issue and deliver at such office to such
holder of Series A Preferred Stock, or to the nominee or nominees of such holder, a certificate or certificates for the number
of shares of Common Stock to which such holder shall be entitled as aforesaid. The person or persons entitled to receive the shares
of Common Stock issuable upon such conversion pursuant to this Section 4 shall be treated for all purposes as the record holder
or holders of such shares of Common Stock as of the effective date of such conversion.



(d)        Other
Distributions. In the event the Corporation shall declare a distribution payable in securities of other persons, evidences
of indebtedness issued by the Corporation or other persons, assets (excluding cash dividends) or options or rights, then, in each
such case for the purpose of this Section 4(d), the holders of the Series A Preferred Stock shall be entitled to a proportionate
share of any such distribution as though they were the holders of the number of shares of Common Stock of the Corporation into
which their shares of Series A Preferred Stock are convertible as of the record date fixed for the determination of the holders
of Common Stock of the Corporation entitled to receive such distribution.



(e)        Recapitalizations.
If at any time or from time to time there shall be a recapitalization of the Common Stock (other than a subdivision, combination
or a reorganization, merger or consolidation transaction provided for elsewhere in this Section 4), provisions shall be made so
that the holders of the Series A Preferred Stock shall thereafter be entitled to receive upon conversion of the Series A Preferred
Stock the number of shares of stock or other securities or property of the Corporation or otherwise, to which a holder of Common
Stock deliverable upon conversion would have been entitled in connection with such recapitalization. In any such case, appropriate
adjustment shall be made in the application of the provisions of this Section 4 with respect to the rights of the holders of the
Series A Preferred Stock after the recapitalization to the end that the provisions of this Section 4 (including adjustment of the
Conversion Prices then in effect and the number of shares issuable upon conversion of the Series A Preferred Stock) shall be applicable
after that event as nearly equivalent as may be practicable.



(f)        Reorganizations,
Mergers or Consolidations. If at any time or from time to time the Common Stock is converted into other securities or property,
whether pursuant to a reorganization, merger, consolidation or otherwise (other than a subdivision, combination or recapitalization
provided for elsewhere in this Section 4 or a transaction constituting a Liquidation Event pursuant to Section 4(c) above), provision
shall be made so that the holders of the Series A Preferred Stock shall thereafter be entitled to receive upon conversion of the
Series A Preferred Stock the number of shares of stock or other securities or property of the Corporation or otherwise, to which
a holder of Common Stock deliverable upon conversion would have been entitled in connection with such transaction.



(g)        No Impairment.
The Corporation will not, by amendment of its Certificate of Incorporation or through any reorganization, recapitalization, transfer
of assets, consolidation, merger, dissolution, issue or sale of securities or any other voluntary action, avoid or seek to avoid
the observance or performance of any of the terms to be observed or performed hereunder by the Corporation, but will at all times
in good faith assist in the carrying out of all the provisions of this Section 4 and in the taking of all such action as may be
necessary or appropriate in order to protect the Conversion Rights of the holders of the Series A Preferred Stock against impairment.



10









(h)        No Fractional
Shares and Certificate as to Adjustments. No fractional shares shall be issued upon the conversion of any share or shares of
the Series A Preferred Stock, and the number of shares of Common Stock to be issued shall be rounded to the nearest whole share
(with 1/2 being rounded upward) and shall be determined on the basis of the total number of shares of Series A Preferred Stock
the holder is at the time converting into Common Stock and the number of shares of Common Stock issuable upon such aggregate conversion.



(i)        Notices
of Record Date. In the event of any taking by the Corporation of a record of the holders of any class of securities for the
purpose of determining the holders thereof who are entitled to receive any dividend or other distribution, any right to subscribe
for, purchase or otherwise acquire any shares of stock of any class or any other securities or property, or to receive any other
right, the Corporation shall mail to each holder of Series A Preferred Stock, at least twenty (20) days prior to the date specified
therein, a notice specifying the date on which any such record is to be taken for the purpose of such dividend, distribution or
right, and the amount and character of such dividend, distribution or right.



(j)        Reservation
of Stock Issuable Upon Conversion. Following the adoption of the Amendment, the Corporation shall at all times reserve and
keep available out of its authorized but unissued shares of Common Stock, solely for the purpose of effecting the conversion of
the shares of the Series A Preferred Stock, such number of its shares of Common Stock as shall from time to time be sufficient
to effect the conversion of all outstanding shares of Series A Preferred Stock; and if at any time the number of authorized but
unissued shares of Common Stock shall not be sufficient to effect the conversion of all then outstanding shares of Series A Preferred
Stock, in addition to such other remedies as shall be available to the holder of Series A Preferred Stock, the Corporation will
take such corporate action as may, in the opinion of its counsel, be necessary to increase its authorized but unissued shares of
Common Stock to such number of shares as shall be sufficient for such purposes, including, without limitation, engaging in best
efforts to obtain the requisite stockholder approval of any necessary amendment to this certificate



(k)        Notices.
Any notice required by the provisions of this Section 4 to be given to the holders of shares of Series A Preferred Stock shall
be deemed given if deposited in the United States mail, postage prepaid, and addressed to each holder of record at his address
appearing on the books of the Corporation.



5.        Voting
Rights. Except as provided by the General Corporation Law of the State of Delaware or as otherwise expressly provided herein
with respect to special class voting arrangements, the holder of each share of Series A Preferred Stock shall have the right to
one vote for each share of Common Stock into which such share of Series A Preferred Stock could then be converted (assuming the
Amendment had been approved and filed), and with respect to such vote, such holder shall have full voting rights and powers equal
to the voting rights and powers of the holders of Common Stock, and shall be entitled, notwithstanding any provision hereof, to
notice of any stockholders’ meeting in accordance with the bylaws of the Corporation, and shall be entitled to vote, together
with holders of Common Stock, with respect to any question upon which holders of Common Stock have the right to vote. For purposes
of clarity, the voting rights of the Series A Preferred Stock shall be effective without regard to whether the Amendment has been
approved and filed. Fractional votes shall not, however, be permitted and any fractional voting rights available on an as-converted
basis (after aggregating all fractional shares into which shares of Series A Preferred Stock held by each holder could be converted)
shall be rounded to the nearest whole number (with one-half being rounded upward).



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Notwithstanding any provision herein to
the contrary. in connection with any acquisition of Series A Preferred Stock (and/or any other voting securities of the Corporation)
as to which the Hart-Scott-Rodino Antitrust Improvements Act of 1976, as amended (the “HSR Act”), would, but for this
section, be applicable, any person or entity (as defined under the HSR Act) acquiring such Series A Preferred Stock (and/or other
voting securities of the Corporation) shall have no right to vote such Series A Preferred Stock or voting securities until such
person or entity has complied with the filing and waiting period requirements of the HSR Act.



6.        Status
of Converted or Redeemed Stock. In the event any shares of Series A Preferred Stock shall be redeemed or converted pursuant
to Section 4, the shares so converted or redeemed shall he cancelled and shall not be issuable by the Corporation. The Certificate
of Incorporation of the Corporation shall be appropriately amended to effect the corresponding reduction in the Corporation’s
authorized capital stock.



IN WITNESS WHEREOF, Manhattan
Pharmaceuticals, Inc. has caused this Certificate of Designation of Series A Preferred Stock to be signed by Michael McGuinness,
its Chief Financial and Operating Officer, this 29th day of December, 2011.









| | TG THERAPEUTICS, INC. (f/k/a MANHATTAN PHARMACEUTICALS, INC.)
| | -------------------------------------------------------------
| |                                                              
| |                                                              
| | By:                                                          
| | Name:                                                        
| | Title:                                                       









12





EXHIBIT
B









13





AMENDED
CERTIFICATE OF DESIGNATIONS,
PREFERENCES AND OTHER RIGHTS
OF
SERIES A PREFERRED STOCK
OF
TG THERAPEUTICS, INC.



Pursuant to Section 151 of the General
Corporation Law of the State of Delaware



The undersigned officer
of TG Therapeutics, Inc., a Delaware corporation (the “Corporation”), pursuant to the provisions of Section 151 of
the General Corporation Law of the State of Delaware, does hereby make this Certificate of Amendment of the Certificate of Designations,
Preferences and Other Rights of Series A Preferred Stock, filed with the office of the Secretary of State on December 29, 2011
(the “Series A Certificate of Designations”), and does hereby state and certify that pursuant to the authority expressly
vested in the Board of Directors of the Corporation by the Certificate of Incorporation, as amended, originally filed with the
office of the Secretary of State of Delaware on May 18, 1993, the Board of Directors duly adopted the following resolutions:



RESOLVED, the Series
A Certificate of Designations is hereby amended as follows:



| | (1) | by striking Section 3 in its entirety and renumbering subsequent Sections 4, 5 and 6 as Sections 3, 4 and 5, respectively.
| | --- | --------------------------------------------------------------------------------------------------------------------------



| | (2) | by striking Section 4(a) in its entirety and substituting the following:
| | --- | ------------------------------------------------------------------------



Automatic Conversion. On the effective date of
the Amendment, each share of Series A Preferred Stock shall automatically be converted into Five Hundred (500) shares of fully
paid and non-assessable Common Stock without any further action of the Company or the holder of Series A Preferred Stock.



| | (3) | by striking the heading of Section 4(b) in its entirety and substituting the following:
| | --- | ---------------------------------------------------------------------------------------



Automatic Conversion
on Business Combination.



This Amended Certificate
of Designations of the Corporation has been duly adopted in accordance with Section 151 of the General Corporation Law of the State
of Delaware.





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The undersigned is signing
this Amended Certificate of Designations on behalf of the Corporation on this day of 13th January, 2012.







| | /s/ Sean Power |                                                 
| | -------------- | ------------------------------------------------
| | Name:          | Sean Power                                      
| | Title:         | Chief Financial Officer, Treasurer and Secretary













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