Federal Register / Vol. 86, No. 174 / Monday, September 13, 2021 / Notices 50899 

5. Chinese Patent Application 

201880063656.4, filed September 17, 

2018 (E–237–2017–1–CN–05); 

6. European Patent Application 

18782605.2, filed September 17, 2018 

(E–237–2017–1–EP–06); 

7. Israeli Patent Application 273516, 

filed September 17, 2018 (E–237–2017– 

1–IL–07); 

8. Japanese Patent Application 2020– 

517553, filed September 17, 2018 (E– 

237–2017–1–JP–08); 

9. Korean Patent Application 2020– 

7012343, filed September 17, 2018 (E– 

237–2017–1–KR–09); 

10. Singapore Patent Application 

11202002635R, filed September 17, 

2018 (E–237–2017–1–SG–10); 

11. United States Utility Patent 

Application 16/650,696, filed 

September 17, 2018 (E–237–2017–1– 

US–11); and 

12. Hong Kong Patent Application 

62020021274.9, filed November 30, 

2020 (E–237–2017–1–HK–12). 

The patent rights in these inventions 

have been assigned and/or exclusively 

licensed to the government of the 

United States of America. 

The prospective exclusive license 

territory may be worldwide and the 

fields of use may be limited to the 

following: 

Fields of Use Applying to Intellectual 

Property Group A 

‘‘Development, manufacture, and 

commercialization of allogeneic Natural 

Killer T (NKT) cell therapy products 

engineered via viral and non-viral means, 

including CRISPR modification, to express T 

cell receptors reactive to mutated P53, KRAS, 

and EGFR within the context of multiple 

HLAs, as claimed in the Licensed Patent 

Rights, for the treatment of human cancers. 

For the purposes of this license, NKT cells 

are a subset of peripheral blood lymphocytes 

specifically and intentionally isolated based 

on unique characteristics of NKT cells 

resulting in a manufactured clinical product 

containing at least 50% NKT cells.’’ 

Fields of Use Applying to Intellectual 

Property Group B 

‘‘Development, manufacture, and 

commercialization of allogeneic Natural 

Killer T (NKT) cell therapy products 

engineered via viral and non-viral means, 

including CRISPR modification, to express T 

cell receptors reactive to mutated P53, 

isolated as claimed in the Licensed Patent 

Rights, for the treatment of human cancers. 

For the purposes of this license, NKT cells 

are a subset of peripheral blood lymphocytes 

specifically and intentionally isolated based 

on unique characteristics of NKT cells 

resulting in a manufactured clinical product 

containing at least 50% NKT cells.’’ 

Intellectual Property Group A 

description is as follows: 

E–237–2017–0, E–135–2019 and E–173– 

2020 patent rights are primarily directed to 

isolated TCRs reactive to mutated tumor 

protein 53 (TP53 or P53), within the context 

of several HLAs. P53 is the archetypal tumor 

suppressor gene and the most frequently 

mutated gene in cancer. Contemporary 

estimates suggest that >50% of all tumors 

carry mutations in P53. Because of its 

prevalence in cancer and its restricted 

expression to precancerous and cancerous 

cells, this antigen may be targeted on mutant 

P53-expressing tumors with minimal normal 

tissue toxicity. 

E–165–2020, E–172–2020, E–189–2020 and 

E–190–2020 patent rights are primarily 

directed to isolated TCRs reactive to mutated 

Kirsten rat sarcoma viral oncogene homolog 

(KRAS), within the context of several human 

leukocyte antigens (HLAs). Mutated KRAS, 

which plays a well-defined driver role in 

oncogenesis, is expressed by a variety of 

human cancers, including: Pancreatic, lung, 

endometrial, ovarian and prostate. Due to its 

restricted expression in precancerous and 

cancerous cells, this antigen may be targeted 

on mutant KRAS-expressing tumors with 

minimal normal tissue toxicity. 

E–098–2018 patent rights are primarily 

directed to isolated TCRs reactive to mutated 

epidermal growth factor receptor (EGFR), 

within the context of HLA DPA1*02:01 

DPB1*01:01. EGFR is a transmembrane 

protein involved in cell growth and 

proliferation signaling. Mutations in the gene 

encoding EGFR can lead to its 

overexpression, causing several types of 

cancer (e.g., non-small cell lung cancer 

(NSCLC)). Because of its prevalence in 

certain cancers and its restricted expression 

to precancerous and cancerous tissues, this 

antigen may be targeted on mutant EGFRexpressing tumors with minimal normal 

tissue toxicity. 

Intellectual Property Group B 

description is as follows: 

E–237–2017–1 patent rights are primarily 

directed to methods of rapidly isolating T 

cells which are reactive to mutated P53 

antigens. Briefly, pools of 25-mer peptides 

covering all known P53 ‘‘hotspot’’ mutations 

have been generated. These peptides may be 

pulsed into antigen presenting cells which 

are subsequently co-cultured with isolated T 

cells. Reactive T cells are then purified and 

may be used as source material for the further 

isolation of mutant P53-targeting TCRs. 

This notice is made in accordance 

with 35 U.S.C. 209 and 37 CFR part 404. 

The prospective exclusive license will 

be royalty bearing, and the prospective 

exclusive license may be granted unless 

within fifteen (15) days from the date of 

this published notice, the National 

Cancer Institute receives written 

evidence and argument that establishes 

that the grant of the license would not 

be consistent with the requirements of 

35 U.S.C. 209 and 37 CFR part 404. 

In response to this Notice, the public 

may file comments or objections. 

Comments and objections, other than 

those in the form of a license 

application, will not be treated 

confidentially, and may be made 

publicly available. 

License applications submitted in 

response to this Notice will be 

presumed to contain business 

confidential information and any release 

of information in these license 

applications will be made only as 

required and upon a request under the 

Freedom of Information Act, 5 U.S.C. 

552. 

Dated: September 7, 2021. 

Richard U. Rodriguez, 

Associate Director, Technology Transfer 

Center, National Cancer Institute. 

[FR Doc. 2021–19604 Filed 9–10–21; 8:45 am] 

BILLING CODE 4140–01–P 

DEPARTMENT OF THE INTERIOR 

Bureau of Land Management 

[L14400000 PN0000 HQ350000 212; OMB 

Control Number 1004–0012] 

Agency Information Collection 

Activities; Application for Land for 

Recreation or Public Purposes 

AGENCY: Bureau of Land Management, 

Interior. 

ACTION: Notice of information collection; 

request for comment. 

SUMMARY: In accordance with the 

Paperwork Reduction Act of 1995 

(PRA), the Bureau of Land Management 

(BLM) proposes to renew an information 

collection. 

DATES: Interested persons are invited to 

submit comments on or before October 

13, 2021. 

ADDRESSES: Written comments and 

recommendations for this information 

collection request (ICR) should be sent 

within 30 days of publication of this 

notice to www.reginfo.gov/public/do/ 

PRAMain. Find this particular 

information collection by selecting 

‘‘Currently under 30-day Review—Open 

for Public Comments’’ or by using the 

search function. 

FOR FURTHER INFORMATION CONTACT: To 

request additional information about 

this ICR, contact Susie Greenhalgh by 

email at lgreenhalgh@blm.gov, or by 

telephone at 202–302–4288. Individuals 

who are hearing or speech impaired 

may call the Federal Relay Service at 1– 

800–877–8339 for TTY assistance. You 

may also view the ICR at http://

www.reginfo.gov/public/do/PRAMain. 

SUPPLEMENTARY INFORMATION: In 

accordance with the PRA and 5 CFR 

1320.8(d)(1), we provide the general 

public and other Federal agencies with 

an opportunity to comment on new, 


lotter on DSK11XQN23PROD with NOTICES1
50900 Federal Register / Vol. 86, No. 174 / Monday, September 13, 2021 / Notices 

proposed, revised, and continuing 

collections of information. This helps us 

assess the impact of our information 

collection requirements and minimize 

the public’s reporting burden. It also 

helps the public understand our 

information collection requirements and 

provide the requested data in the 

desired format. 

A Federal Register notice with a 60- 

day public comment period soliciting 

comments on this collection of 

information was published on May 4, 

2021 (86 FR 23737). No comments were 

received. 

As part of our continuing effort to 

reduce paperwork and respondent 

burdens, we are again soliciting 

comments from the public and other 

Federal agencies on the proposed ICR 

that is described below. We are 

especially interested in public comment 

addressing the following: 

(1) Whether or not the collection of 

information is necessary for the proper 

performance of the functions of the 

agency, including whether or not the 

information will have practical utility; 

(2) The accuracy of our estimate of the 

burden for this collection of 

information, including the validity of 

the methodology and assumptions used; 

(3) Ways to enhance the quality, 

utility, and clarity of the information to 

be collected; and 

(4) How might the agency minimize 

the burden of the collection of 

information on those who are to 

respond, including through the use of 

appropriate automated, electronic, 

mechanical, or other technological 

collection techniques or other forms of 

information technology, e.g., permitting 

electronic submission of response. 

Comments that you submit in 

response to this notice are a matter of 

public record. Before including your 

address, phone number, email address, 

or other personal identifying 

information in your comment, you 

should be aware that your entire 

comment—including your personal 

identifying information—may be made 

publicly available at any time. While 

you can ask us in your comment to 

withhold your personal identifying 

information from public review, we 

cannot guarantee that we will be able to 

do so. 

Abstract: The BLM uses the 

information collection to decide 

whether or not to lease or sell certain 

public lands to applicants under the 

Recreation and Public Purposes Act, 43 

U.S.C. 869 to 869–4. OMB Control 

Number 1004–0012 is scheduled to 

expire on October 31, 2021. This request 

is for OMB to renew this OMB Control 

Number for an additional three (3) 

years. 

Title of Collection: Application for 

Land for Recreation or Public Purposes 

(43 CFR 2740 and 2912). 

OMB Control Number: 1004–0012. 

Form Number: 2740–01. 

Type of Review: Extension of a 

currently approved collection. 

Respondents/Affected Public: State, 

Territory, County, and Local 

governments; nonprofit corporations; 

and nonprofit associations. 

Total Estimated Number of Annual 

Respondents: 23. 

Total Estimated Number of Annual 

Responses: 23. 

Estimated Completion Time per 

Response: 40 hours. 

Total Estimated Number of Annual 

Burden Hours: 920. 

Respondent’s Obligation: Required to 

obtain or retain a benefit. 

Frequency of Collection: On occasion. 

Total Estimated Annual Non-hour 

Burden Cost: $2,300. 

An agency may not conduct or 

sponsor and, notwithstanding any other 

provision of law, a person is not 

required to respond to a collection of 

information unless it displays a 

currently valid OMB control number. 

The authority for this action is the 

Paperwork Reduction Act of 1995 (44 

U.S.C. 3501 et seq.). 

Darrin King, 

Information Collection Clearance Officer. 

[FR Doc. 2021–19624 Filed 9–10–21; 8:45 am] 

BILLING CODE 4310–84–P 

DEPARTMENT OF THE INTERIOR 

National Park Service 

[NPS–WASO–NAGPRA–NPS0032516; 

PPWOCRADN0–PCU00RP14.R50000] 

Notice of Inventory Completion: Illinois 

State Museum, Springfield, IL 

AGENCY: National Park Service, Interior. 

ACTION: Notice. 

SUMMARY: The Illinois State Museum 

has completed an inventory of human 

remains and associated funerary objects, 

in consultation with the appropriate 

Indian Tribes or Native Hawaiian 

organizations, and has determined that 

there is a cultural affiliation between the 

human remains and associated funerary 

objects and present-day Indian Tribes or 

Native Hawaiian organizations. Lineal 

descendants or representatives of any 

Indian Tribe or Native Hawaiian 

organization not identified in this notice 

that wish to request transfer of control 

of these human remains and associated 

funerary objects should submit a written 

request to the Illinois State Museum. If 

no additional requestors come forward, 

transfer of control of the human remains 

and associated funerary objects to the 

lineal descendants, Indian Tribes, or 

Native Hawaiian organizations stated in 

this notice may proceed. 

DATES: Lineal descendants or 

representatives of any Indian Tribe or 

Native Hawaiian organization not 

identified in this notice that wish to 

request transfer of control of these 

human remains and associated funerary 

objects should submit a written request 

with information in support of the 

request to the Illinois State Museum at 

the address in this notice by October 13, 

2021. 

FOR FURTHER INFORMATION CONTACT: Dr. 

Brooke Morgan, Illinois State Museum 

Research & Collections Center, 1011 

East Ash Street, Springfield, IL 62703, 

telephone (217) 785–8930, email 

Brooke.Morgan@illinois.gov. 

SUPPLEMENTARY INFORMATION: Notice is 

here given in accordance with the 

Native American Graves Protection and 

Repatriation Act (NAGPRA), 25 U.S.C. 

3003, of the completion of an inventory 

of human remains and associated 

funerary objects under the control of the 

Illinois State Museum, Springfield, IL. 

The human remains and associated 

funerary objects were removed from 

Grundy County, IL. 

This notice is published as part of the 

National Park Service’s administrative 

responsibilities under NAGPRA, 25 

U.S.C. 3003(d)(3). The determinations in 

this notice are the sole responsibility of 

the museum, institution, or Federal 

agency that has control of the Native 

American human remains and 

associated funerary objects. The 

National Park Service is not responsible 

for the determinations in this notice. 

Consultation 

A detailed assessment of the human 

remains was made by the Illinois State 

Museum professional staff in 

consultation with representatives of the 

Forest County Potawatomi Community, 

Wisconsin; Nottawaseppi Huron Band 

of the Potawatomi, Michigan 

[previously listed as Huron Potawatomi, 

Inc.]; Peoria Tribe of Indians of 

Oklahoma; and the Winnebago Tribe of 

Nebraska. In addition, the Citizen 

Potawatomi Nation, Oklahoma; 

Hannahville Indian Community, 

Michigan; Ho-Chunk Nation of 

Wisconsin; Kickapoo Traditional Tribe 

of Texas; Kickapoo Tribe of Indians of 

the Kickapoo Reservation in Kansas; 

Kickapoo Tribe of Oklahoma; Match-ebe-nash-she-wish Band of Pottawatomi 


lotter on DSK11XQN23PROD with NOTICES1