**CERTIFICATIONS**

| 1. |   | I                have reviewed this Quarterly Report on Form 10-Q of Manhattan                Pharmaceuticals, Inc. (the “Registrant”); |
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| 2. |   | Based                on my knowledge, this report does not contain any untrue statement                of a                material fact or omit to state a material fact necessary to make                the                statements made, in light of the circumstances under which such statements                were made, not misleading with respect to the period covered by this                report; |
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| 3. |   | Based                on my knowledge, the financial statements, and other financial information                included in this report, fairly present in all material respects                the                financial condition, results of operations and cash flows of the                Registrant as of, and for, the periods presented in this report; |
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| 4. |   | The                Registrant’s other certifying officer(s) and I are responsible for                establishing and maintaining disclosure controls and procedures (as                defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) for the Registrant                and have: |
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|  |   | (a)                Designed such disclosure controls and procedures, or caused such                disclosure controls and procedures to be designed under our supervision,                to ensure that material information relating to the Registrant, including                its consolidated subsidiaries, is made known to us by others within                those                entities, particularly during the period in which this report is                being                prepared; |
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|  |   | (b)                Evaluated the effectiveness of the Registrant's disclosure controls                and                procedures and presented in this report our conclusions about the                effectiveness of the disclosure controls and procedures, as of the                end of                the period covered by this report based on such evaluation;                and  |
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|  |   | (c)                Disclosed in this report any change in the Registrant’s internal control                over financial reporting that occurred during the Registrant’s most recent                fiscal quarter (the Registrant’s fourth fiscal quarter in the case of an                annual report) that has materially affected, or is reasonably likely                to                materially affect, the Registrant’s internal control over financial                reporting; and |
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| 5. |   | The                Registrant’s other certifying officer(s) and I have disclosed, based on                our most recent evaluation of internal control over financial reporting,                to the Registrant’s auditors and the audit committee of the Registrant’s                board of directors (or persons performing the equivalent functions):  |
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|  |   | (a)                All                significant deficiencies and material weaknesses in the design or                operation of internal control over financial reporting which are                reasonably likely to adversely affect the Registrant’s ability to record,                process, summarize and report financial information;                and |
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|  |   | (b)                Any                fraud, whether or not material, that involves management or other                employees who have a significant role in the Registrant’s internal control                over financial                reporting.  |
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| Date: August              14, 2007 |                                                                  | /s/ Douglas              Abel |
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|                                    | Douglas              Abel                                             |
|                                    | President              and              Chief Executive Officer  |

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