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 Department of Justice Drug Enforcement Administration [Docket No. DEA-898]
 AGENCY: Drug Enforcement Administration, Justice.
 ACTION: Notice of application.
 SUMMARY: Cayman Chemical Company, has applied to be registered as a bulk manufacturer of basic class(es) of controlled substance(s). Refer to 
                        **Supplementary Information**
                         listed below for further drug information.
 DATES: Registered bulk manufacturers of the affected basic class(es), and applicants therefore, may file written comments on or objections to the issuance of the proposed registration on or before November 12, 2021. Such persons may also file a written request for a hearing on the application on or before November 12, 2021.
 ADDRESSES: Written comments should be sent to: Drug Enforcement Administration, Attention: DEA Federal Register Representative/DPW, 8701 Morrissette Drive, Springfield, Virginia 22152.


SUPPLEMENTARY INFORMATION: In accordance with 21 CFR 1301.33(a), this is notice that on July 15, 2021, Cayman Chemical Company, 1180 East Ellsworth Road, Ann Arbor, Michigan 48108-2419, applied to be registered as a bulk manufacturer of the following basic class(es) of controlled substance(s): Controlled substance
Drug code
Schedule3-Fluoro-N-methylcathinone (3-FMC)
1233
ICathinone
1235
IMethcathinone
1237
I4-Fluoro-N-methylcathinone (4-FMC)
1238
IPentedrone (α-methylaminovalerophenone)
1246
IMephedrone (4-Methyl-N-methylcathinone)
1248
I4-Methyl-N-ethylcathinone (4-MEC)
1249
INaphyrone
1258
IN-Ethylamphetamine
1475
IN,N-Dimethylamphetamine
1480
IFenethylline
1503
IAminorex
1585
I4-Methylaminorex (cis isomer)
1590
IGamma Hydroxybutyric Acid
2010
IMethaqualone
2565
IMecloqualone
2572
IJWH-250 (1-Pentyl-3-(2-methoxyphenylacetyl) indole)
6250
ISR-18 (Also known as RCS-8) (1-Cyclohexylethyl-3-(2-methoxyphenylacetyl) indole)
7008
IADB-FUBINACA (n-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-1-(4-fluorobenzyl)-1H-indazole-3-carboxamide)
7010
I5-Flouro-UR-144 and XLR11 [1-(5-Fluoro-pentyl)1H-indol-3-yl](2,2,3,3-tetramethylcyclopropyl)methanone
7011
IAB-FUBINACA (N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-(4-fluorobenzyl)-1H-indazole-3-carboxamide)
7012
I(1-(4-Fluorobenzyl)-1H-indol-3-yl)(2,2,3,3tetramethylcyclopropyl)methanone
7014
IJWH-019 (1-Hexyl-3-(1-naphthoyl)indole)
7019
IMDMB-FUBINACA (Methyl 2-(1-4-fluorobenzyl)-1H-indazole-3-carboxamido)-3,3-dimethylbutanoate)
7020
I2-(1-(4-fluorobenzyl)-1Hindazole-3-carboxamido)-3- methylbutanoate
7021
IAB-PINACA (N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-pentyl-1H-indazole-3-carboxamide)
7023
ITHJ-2201 [1-(5-fluoropentyl)-1H-indazol-3-yl](naphthalen-1-yl)methanone
7024
I5F-AB-PINACA (N-(1-amino-3-methyl-1-oxobutan-2-yl)1-(5-fluoropentyl)-1 H-indazole-3-carboxamide)
7025
IAB-CHMINACA (N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-(cyclohexylmethyl)-1H-indazole-3-carboxamide
7031
IMAB-CHMINACA (N-(1-amino-3,3dimethyl-1-oxobutan-2-yl)-1-(cyclohexylmethyl)-1H-indazole-3-carboxamide)
7032
I5F-AMB (Methyl 2-(1-(5-fluoropentyl)-1H-indazola-3-carboxamido)-3-methylbutanoate)
7033
I5F-ADB; 5F-MDMB-PINACA (Methyl 2-(1-(5fluoropentyl)-1H-indazole-3-carboxamido)-3,3dimethylbutanoate)
7034
IADB-PINACA (N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-1-pentyl-1H-indazole-3-carboxamide)
7035
IEthyl 2-(1-(5-fluoropentyl)-1H-indazole-3-carboxamido)3,3-dimethylbutanoate
7036
IMethyl 2-(1-(5-fluoropentyl)-1H-indole-3-carboxamido)3,3-dimethylbutanoate
7041
IMDMB-CHMICA, MMB-CHMINACA (Methyl 2-(1-(cyclohenxylmethyl)-1H-indole-3-carboxamido)-3,3-dimethylbutanote)-
7042
IMMB-CHMICA, AMB-CHMICA (methyl 2-(1(cyclohexylmethyl)-1 H-indole-3-carboxamido)-3methylbutanoate)
7044
IN-(Adamantan-1-yl)-1-(4-fluorobenzyl)-1H-indazole-3carboxamide
7047
IAPINACA and AKB48 N-(1-Adamantyl)-1-pentyl-1H-indazole-3-carboxamide
7048
I5F-APINACA, 5F-AKB48 (N-(adamantan-1-yl)-1-(5fluoropentyl)-1H-indazole-3-carboxamide)
7049
IJWH-081 (1-Pentyl-3-(1-(4-methoxynaphthoyl) indole)
7081
I1-(5-Fluoropentyl)-N-(2-phenylpropan-2-yl)-1H-indazole3-carboxamide
7083
I5F-CUMYL-P7AICA (1-(5-fluoropentyl)-N-(2phenylpropan-2-yl)-1 H-pyrrolo[2,3-b]pyridine-3carboxamide)
7085
I4-CN-CUMYL-BUTINACA (1-(4-cyanobutyl)-N-(2phenylpropan-2-yl)-1 H-indazole-3-carboxamide)
7089
ISR-19 (Also known as RCS-4) (1-Pentyl-3-[(4-methoxy)-benzoyl] indole
7104
IJWH-018 (also known as AM678) (1-Pentyl-3-(1-naphthoyl)indole)
7118
IJWH-122 (1-Pentyl-3-(4-methyl-1-naphthoyl) indole)
7122
IUR-144 (1-Pentyl-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone
7144
IJWH-073 (1-Butyl-3-(1-naphthoyl)indole)
7173
IJWH-200 (1-[2-(4-Morpholinyl)ethyl]-3-(1-naphthoyl)indole)
7200
IAM2201 (1-(5-Fluoropentyl)-3-(1-naphthoyl) indole)
7201
IJWH-203 (1-Pentyl-3-(2-chlorophenylacetyl) indole)
7203
INM2201; CBL2201 (Naphthalen-1-yl 1-(5-fluoropentyl)1 H-indole-3-carboxylate)
7221
IPB-22 (Quinolin-8-yl 1-pentyl-1H-indole-3-carboxylate)
7222
I5F-PB-22 (Quinolin-8-yl 1-(5-fluoropentyl)-1H-indole-3-carboxylate)
7225
I4-methyl-alpha-ethylaminopentiophenone (4-MEAP)
7245
I( print page 50905)N-ethylhexedrone
7246
IAlpha-ethyltryptamine
7249
IIbogaine
7260
ICP-47,497 (5-(1,1-Dimethylheptyl)-2-[(1R,3S)-3-hydroxycyclohexyl-phenol)
7297
ICP-47,497 C8 Homologue (5-(1,1-Dimethyloctyl)-2-[(1R,3S)3-hydroxycyclohexyl-phenol)
7298
ILysergic acid diethylamide
7315
I2,5-Dimethoxy-4-(n)-propylthiophenethylamine (2C-T-7)
7348
IMarihuana
7360
ITetrahydrocannabinols
7370
IMescaline
7381
I2-(4-Ethylthio-2,5-dimethoxyphenyl) ethanamine (2C-T-2 )
7385
I3,4,5-Trimethoxyamphetamine
7390
I4-Bromo-2,5-dimethoxyamphetamine
7391
I4-Bromo-2,5-dimethoxyphenethylamine
7392
I4-Methyl-2,5-dimethoxyamphetamine
7395
I2,5-Dimethoxyamphetamine
7396
IJWH-398 (1-Pentyl-3-(4-chloro-1-naphthoyl) indole)
7398
I2,5-Dimethoxy-4-ethylamphetamine
7399
I3,4-Methylenedioxyamphetamine
7400
I5-Methoxy-3,4-methylenedioxyamphetamine
7401
IN-Hydroxy-3,4-methylenedioxyamphetamine
7402
I3,4-Methylenedioxy-N-ethylamphetamine
7404
I3,4-Methylenedioxymethamphetamine
7405
I4-Methoxyamphetamine
7411
I5-Methoxy-N-N-dimethyltryptamine
7431
IAlpha-methyltryptamine
7432
IDiethyltryptamine
7434
IDimethyltryptamine
7435
IPsilocybin
7437
IPsilocyn
7438
I5-Methoxy-N,N-diisopropyltryptamine
7439
I4-chloro-alpha-pyrrolidinovalerophenone (4-chloro-a-PVP)
7443
I4′-methyl-alpha-pyrrolidinohexiophenone (MPHP)
7446
IN-Ethyl-1-phenylcyclohexylamine
7455
I1-(1-Phenylcyclohexyl)pyrrolidine
7458
I1-[1-(2-Thienyl)cyclohexyl]piperidine
7470
I1-[1-(2-Thienyl)cyclohexyl]pyrrolidine
7473
IN-Benzylpiperazine
7493
I2-(2,5-Dimethoxy-4-methylphenyl) ethanamine (2C-D)
7508
I2-(2,5-Dimethoxy-4-ethylphenyl) ethanamine (2C-E )
7509
I2-(2,5-Dimethoxyphenyl) ethanamine (2C-H)
7517
I2-(4-iodo-2,5-dimethoxyphenyl) ethanamine (2C-I)
7518
I2-(4-Chloro-2,5-dimethoxyphenyl) ethanamine (2C-C)
7519
I2-(2,5-Dimethoxy-4-nitro-phenyl) ethanamine (2C-N)
7521
I2-(2,5-Dimethoxy-4-(n)-propylphenyl) ethanamine (2C-P)
7524
I2-(4-Isopropylthio)-2,5-dimethoxyphenyl) ethanamine (2C-T-4 )
7532
IMDPV (3,4-Methylenedioxypyrovalerone)
7535
I2-(4-bromo-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl) ethanamine (25B-NBOMe)
7536
I2-(4-chloro-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl) ethanamine (25C-NBOMe)
7537
I2-(4-iodo-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl) ethanamine (25I-NBOMe)
7538
IMethylone (3,4-Methylenedioxy-N-methylcathinone)
7540
IButylone
7541
IPentylone
7542
Ialpha-pyrrolidinohexanophenone (a-PHP)
7544
Ialpha-pyrrolidinopentiophenone (α-PVP)
7545
Ialpha-pyrrolidinobutiophenone (α-PBP)
7546
IEthylone
7547
Ialpha-pyrrolidinoheptaphenone (PV8)
7548
IAM-694 (1-(5-Fluoropentyl)-3-(2-iodobenzoyl) indole)
7694
IAcetyldihydrocodeine
9051
IBenzylmorphine
9052
ICodeine-N-oxide
9053
IDesomorphine
9055
IEtorphine (except HCl)
9056
ICodeine methylbromide
9070
IBrorphine
9098
IDihydromorphine
9145
IDifenoxin
9168
IHeroin
9200
IHydromorphinol
9301
IMorphine-N-oxide
9307
INormorphine
9313
IU-47700 (3,4-dichloro-N-[2-(dimethylamino)cyclohexyl]-N-methylbenzamide)
9547
IMT-45 (1-cyclohexyl-4-(1,2-diphenylethyl)piperazine))
9560
I( print page 50906)Clonitazene
9612
IIsotonitazene (N,N-diethyl-2-(2-(4 isopropoxybenzyl)-5-nitronitro-1H-benzimidazol-1-yl)ethan-1-amine)
9614
IEtonitazene
9624
IKetobemidone
9628
ITrimeperidine
9646
ITilidine
9750
IAcryl fentanyl (N-(1-phenethylpiperidin-4-yl)-N-phenylacrylamide)
9811
IPara-Fluorofentanyl
9812
I3-Methylfentanyl
9813
IAlpha-methylfentanyl
9814
IAcetyl-alpha-methylfentanyl
9815
IN-(2-fluorophenyl)-N-(1-phenethylpiperidin-4-yl)propionamide
9816
IPara-Methylfentanyl (N-(4-methylphenyl)-N-(1phenethylpiperidin-4-yl)propionamide; also known as 4methylfentanyl)
9817
I4′-Methyl acetyl fentanyl (N-(1-(4methylphenethyl)piperidin-4-yl)-N-phenylacetamide)
9819
Iortho-Methyl methoxyacetyl fentanyl (2-methoxy-N-(2methylphenyl)-N-(1-phenethylpiperidin-4-yl)acetamide)
9820
IAcetyl Fentanyl (N-(1-phenethylpiperidin-4-yl)-N-phenylacetamide)
9821
IButyryl Fentanyl
9822
IPara-fluorobutyryl fentanyl
9823
I4-Fluoroisobutyryl fentanyl (N-(4-fluorophenyl)-N-(1phenethylpiperidin-4-yl)isobutyramide)
9824
I2-methoxy-N-(1-phenethylpiperidin-4-yl)-N-phenylacetamide
9825
IPara-chloroisobutyryl fentanyl
9826
IIsobutyryl fentanyl
9827
IBeta-hydroxyfentanyl
9830
IBeta-hydroxy-3-methylfentanyl
9831
IAlpha-methylthiofentanyl
9832
I3-Methylthiofentanyl
9833
IFuranyl fentanyl (N-(1-phenethylpiperidin-4-yl)-N-phenylfuran-2-carboxamide)
9834
IThiofentanyl
9835
IBeta-hydroxythiofentanyl
9836
IPara-methoxybutyryl fentanyl
9837
IOcfentanil
9838
IThiofuranyl fentanyl (N-(1-phenethylpiperidin-4-yl)-Nphenylthiophene-2-carboxamide; also known as 2thiofuranyl fentanyl; thiophene fentanyl)
9839
IValeryl fentanyl
9840
IPhenyl fentanyl (N-(1-phenethylpiperidin-4-yl)-Nphenylbenzamide; also known as benzoyl fentanyl)
9841
Ibeta′-Phenyl fentanyl (N-(1-phenethylpiperidin-4-yl)-N,3diphenylpropanamide; also known as β′-phenyl fentanyl; 3-phenylpropanoyl fentanyl)
9842
IN-(1-phenethylpiperidin-4-yl)-N-phenyltetrahydrofuran2-carboxamide
9843
ICrotonyl fentanyl ((E)-N-(1-phenethylpiperidin-4-yl)-Nphenylbut-2-enamide)
9844
ICyclopropyl Fentanyl
9845
Iortho-Fluorobutyryl fentanyl (N-(2-fluorophenyl)-N-(1phenethylpiperidin-4-yl)butyramide; also known as 2fluorobutyryl fentanyl)
9846
ICyclopentyl fentanyl
9847
Iortho-Methyl acetylfentanyl (N-(2-methylphenyl)-N-(1phenethylpiperidin-4-yl)acetamide; also known as 2methyl acetylfentanyl)
9848
IFentanyl related-substances as defined in 21 CFR 1308.11(h)
9850
IFentanyl carbamate (ethyl (1-phenethylpiperidin-4yl)(phenyl)carbamate)
9851
Iortho-Fluoroacryl fentanyl (N-(2-fluorophenyl)-N-(1phenethylpiperidin-4-yl)acrylamide)
9852
Iortho-Fluoroisobutyryl fentanyl (N-(2-fluorophenyl)-N-(1phenethylpiperidin-4-yl)isobutyramide)
9853
IPara-Fluoro furanyl fentanyl (N-(4-fluorophenyl)-N-(1phenethylpiperidin-4-yl)furan-2-carboxamide)
9854
I2′-Fluoro ortho-fluorofentanyl (N-(1-(2fluorophenethyl)piperidin-4-yl)-N-(2fluorophenyl)propionamide; also known as 2′-fluoro 2fluorofentanyl)
9855
Ibeta-Methyl fentanyl (N-phenyl-N-(1-(2phenylpropyl)piperidin-4-yl)propionamide; also known as β-methyl fentanyl)
9856
IAmphetamine
1100
IIMethamphetamine
1105
IILisdexamfetamine
1205
IIPhenmetrazine
1631
IIMethylphenidate
1724
IIAmobarbital
2125
IIPentobarbital
2270
IISecobarbital
2315
IIGlutethimide
2550
II1-Phenylcyclohexylamine
7460
IIPhencyclidine
7471
II4-Anilino-N-phenethyl-4-piperidine (ANPP)
8333
IINorfentanyl
8366
IIPhenylacetone
8501
II1-Piperidinocyclohexanecarbonitrile
8603
IICocaine
9041
IICodeine
9050
IIEtorphine HCl
9059
IIDihydrocodeine
9120
IIOxycodone
9143
IIHydromorphone
9150
II( print page 50907)Ecgonine
9180
IIEthylmorphine
9190
IIHydrocodone
9193
IILevomethorphan
9210
IILevorphanol
9220
IIIsomethadone
9226
IIMeperidine
9230
IIMeperidine intermediate-B
9233
IIOliriceridine
9245
IIMethadone
9250
IIDextropropoxyphene, bulk (non-dosage forms)
9273
IIMorphine
9300
IIThebaine
9333
IIOxymorphone
9652
IINoroxymorphone
9668
IIThiafentanil
9729
IIAlfentanil
9737
IIRemifentanil
9739
IISufentanil
9740
IICarfentanil
9743
IITapentadol
9780
IIFentanyl
9801
II
 The company plans to bulk manufacture the listed controlled substances for internal use or for sale to its customers. In reference to dug codes 7360 (Marihuana), and 7370 (Tetrahydrocannabinols), the company plans to bulk manufacture these drugs as synthetic. No other activities for these drug codes are authorized for this registration. Brian S. Besser, Acting Assistant Administrator.


[FR Doc. 2021-19632 Filed 9-10-21; 8:45 am] BILLING CODE P