# Patent

## Title
Disinfection device and method

## Abstract

An ultraviolet area sterilizer or disinfector is incorporated into a building structure where concern exists regarding the presence of pathogenic bacteria on environmental surfaces. Ultraviolet C (UV-C) generators generate UV-C that is directed to architectural partitions of an enclosed area. The architectural partitions reflect UV-C to kill pathogens in the enclosed area. The device transmits a calculated dose of UV-C from a fixture mounted to an architectural partition in the enclosed area. Once an effective cumulative dose of UV-C has been reflected to radiation sensors, as measured by the sensors, the device shuts down. The device may allocate power to specific UV-C emitters so as to direct UV-C radiation more uniformly throughout the area, as measured by the sensors.

## Background
This application is a continuation of application Ser. No. 13/303,694 filed Nov. 23, 2011, which claims priority from application Ser. No. 12/361,810 filed Jan. 29, 2009, now U.S. Pat. No. 8,067,750, issued Nov. 29, 2011, which claims priority from provisional Application Ser. No. 61/024,373, filed Jan. 29, 2008; and provisional Application Ser. No. 61/083,590, filed Jul. 25, 2008, and in which Applicant claims priority.


FIELD OF THE INVENTION
This invention relates to methods and devices for bacterial, fungal and/or viral sterilization and disinfection, and is more particularly directed to a method and device for disinfecting rooms and similar enclosed areas.
BACKGROUND OF THE INVENTION
Nosocomial, or hospital acquired, infections are common, costly, and sometimes lethal. A recent review of such infections in the cardiac surgery unit of a major hospital revealed a nosocomial infection rate of 27.3% that more than doubled the mortality rate for afflicted patients. The nature of bacteria acquired in the hospital setting differs significantly from bacteria found in a community setting primarily in their resistance to antibiotic therapy.

    
    
        “Historically, staphylococci, pseudomonads, and Escherichia coli have been the nosocomial infection troika; nosocomial pneumonia, surgical wound infections, and vascular access-related bacteremia have caused the most illness and death in hospitalized patients; and intensive care units have been the epicenters of antibiotic resistance. Acquired antimicrobial resistance is the major problem, and vancomycin-resistant Staphylococcus aureus is the pathogen of greatest concern. The shift to outpatient care is leaving the most vulnerable patients in hospitals. Aging of our population and increasingly aggressive medical and surgical interventions, including implanted foreign bodies, organ transplantations, and xenotransplantation, create a cohort of particularly susceptible persons. Renovation of aging hospitals increases risk of airborne fungal and other infections.
    
    


Significant morbidity, mortality, and costs are associated with these infections. Many factors contribute to these dangerous infections. Most notably is the overuse of antibiotics and poor personal hygiene such as hand washing. Abundant evidence exists, however, that the hospital environment itself contributes to the problem by harboring virulent strains of bacteria, fungi, and viruses, and that many methods commonly used are ineffective and may actually spread contaminants.
Attempts to eradicate surface contaminates from the hospital setting have varied greatly in strategy and success. These have ranged from antiseptic soaps to fumigation with formaldehyde gas. Topical antiseptics are problematic for several reasons. First, they have recently been shown to actually induce antibiotic resistances and thus may be adding to the problem. Secondly, many surfaces such as keyboards, television sets, and monitoring controls are difficult if not impossible to decontaminate with liquid disinfectants without harming the electronics. Gas disinfection, while effective, is time consuming, hazardous to workers, and environmentally unwise.
Ultraviolet (UV) light has been long used for disinfection and sterilization. Ultraviolet light may be produced artificially by electric-arc lamps. Recently, the widespread availability of low to medium pressure mercury bulbs has led to the development of devices which use UV-C to decontaminate water supplies. UV-C is a high frequency wavelength of light within the ultraviolet band and has been shown to be the most bactericidal type of ultraviolet light. UV-C has wavelengths of about 2800 Å to 150 Å. To date, there are no published efforts to use UV-C to decontaminate or disinfect larger areas such as operating rooms. The only recent availability of the appropriate bulbs as well as significant safety concerns regarding worker exposure to UV-C likely contribute to the lack of efforts to use UV-C outside of self-contained water purification systems.
SUMMARY OF THE INVENTION
An ultraviolet area sterilizer or disinfector for use where concern exists regarding the presence of pathogens on environmental surfaces. Ultraviolet C (UV-C) generators generate UV-C radiation that is directed into an enclosed area. The direct and reflected UV-C radiation kills pathogens in the enclosed area. The device transmits a calculated dose of UV-C radiation in the enclosed area. Once an effective cumulative dose of UV-C radiation has been reflected to radiation sensors, as measured by the sensors, the device shuts down. The device allocates power to specific UV-C emitters so as to direct UV-C radiation more uniformly throughout the area, as measured by the sensors.



DESCRIPTION OF THE DRAWINGS
FIG. 1 is a perspective view of a medical facility room incorporating the invention.
FIG. 2 is a plan view of an array of bulbs.
FIG. 3 is a schematic of the device.
FIG. 4 is a schematic of the controls of the device.
FIG. 5A is an elevation of a lighting fixture that incorporates UV-C bulbs.
FIG. 5B shows the fixture of FIG. 5A with louvers in an open position for actuation of the bulbs.
FIG. 6A is a bottom plan view of a lighting fixture that incorporates UV-C bulbs
FIG. 6B shows the fixture of FIG. 6A with louvers in an open position for actuation of the bulbs
FIG. 7 is a schematic of a pulse width modulation control of a light emitting diode (LED) UV-C bulb.



DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENT
The examples given in the discussion of preferred embodiments are fixtures to buildings or rooms to buildings. However, the elements of the device as described herein may also be incorporated in a mobile device that is portable, as described in Deal, U.S. Pat. No. 6,656,424. The power allocation device and method as described herein is useful with fixed and portable devices and methods of ultraviolet-C (UVC) disinfection.
Referring now to the drawing figures, banks of UV-C emitting bulbs 8 are positioned in an architectural partition, which could be a wall, but may be a ceiling 2 of the enclosed area. The enclosed area may be a room located in a building. FIG. 1.
In one embodiment, four (4) pairs of medium pressure mercury bulbs may be present in a fixture that is located in a ceiling of a room. FIG. 2. The bulbs may be 48-inch long, 115-Watt UV-C generating lamps or bulbs that produce 300 microwatts of ultraviolet radiation at 1 meter. Other effective UV-C generators or bulbs may be used. As will be understood by one skilled in the art, the UV-C generators or bulbs may be one or more arrays of light emitting diodes (LEDs) that emit UV-C radiation. Each pair of bulbs is preferred to be positioned to provide coverage of specific portions of the entire room. The lamps or bulbs may be positioned between ceiling tiles that are commonly used in commercial buildings, including hospitals and medical clinics. The lamps or bulbs may be positioned in a similar manner to fluorescent bulb arrays that are used as lighting in buildings.
One advantage of using the bulbs in multiple fixtures, with the fixtures affixed to walls and/or ceilings of real property is that broad coverage of the room may be achieved, with the UV-C radiation emanating from multiple locations that are remote from each other and over a relatively large area. Optimal positioning of the bulbs according the requirements of the particular room may be achieved. If a portable unit is used, the dissemination of UV-C radiation is limited to a radius around the machine.
A base, such as a lighting fixture, is provided for the lamps or bulbs. The base or fixture may be positioned in the ceiling between ceiling tiles and/or HVAC outlets. The lamps or bulbs are positioned to direct UV-C radiation from overhead toward the room structure, and toward furniture 4, fixtures 6 and equipment within the room. The UV-C radiation is reflected from surfaces in the room, and particularly, the flat and preferably light colored wall surfaces, so that the UV-C radiation is received both directly and indirectly, by reflection, to substantially all surfaces in the room. Surfaces that are not in a direct, unobstructed line with the UV-C emitters will receive UV-C radiation in a dosage that is effective to achieve adequate disinfection of the room due to reflection from other surfaces in the room as measured by the UV-C sensors.
UV-C sensors, such as sensor 18a, may be mounted in the ceiling, such as in ceiling tiles, and positioned so as to receive reflected radiation that is reflected from objects in the room or the walls and floors of the room, without receiving material levels of UV-C radiation directly from the UV-C lamps. That is, one or more of the sensors may be mounted in the same flat, planar architectural partition as the UV-C bulbs or emitters so that the sensors do not receive direct radiation, but rather, they receive reflected radiation that is reflected from surfaces in the room. The bulbs 8 are preferred to be recessed within a fixture, and the sensor may also recessed within a ceiling or similar plane, so that the sensor does not receive direct radiation from the bulbs.
Sensors may be mounted on fixtures or objects located in the room. Multiple sensors may be positioned in the room. These sensors may be connected to controls by wire, or by wireless communication. None of the sensors shown in FIG. 1 receive a material dose of UV-C radiation directly from the UV-C bulbs. Sensors 18b and 18c are shown as being positioned under objects in the room, such as beds, tables or other furniture 4, equipment or fixtures. These sensors are positioned so that they do not receive direct radiation from the UV-C bulbs 8. Similarly, sensor 18a, by being positioned in the ceiling, does not receive direct radiation from the UV-C bulbs, but only such UV-C radiation as is reflected to it.
In another embodiment, the bulbs 8 are mounted below the ceiling, but just below the ceiling. The bulbs should be at least two (2) meters above the floor, and it is preferred that the highest bulb is mounted not more than 15 centimeters from the ceiling. In one embodiment, the bulbs are mounted in one or more corners of the enclosed area or room, and are positioned for maximum reflectivity toward the darkest corner of the room. In an embodiment, the bulbs are mounted in a room in a corner and just below the ceiling, with the bulbs direct to a diagonally opposite corner of the room that is the darkest corner of the room. The darkest corner of the room is the corner that is measured to receive the lowest level of reflected radiation. If the run time of the bulbs, as determined by the cumulative dosage received by the sensors, exceeds a pre-set time limit, then an additional bulb or bulbs, spaced apart from other arrays of bulbs, should be added.
In one embodiment, a sensor is mounted in the same corner of a room or enclosed area as an array of bulbs. The sensor is positioned so as to not receive direct radiation. The sensor is positioned within and surrounded by a surround which acts to shield to shield the receiver sensor from direct radiation, but allows reflected radiation to be received. This may be accomplished in one embodiment by placing the sensor in a tube, with an opening in the end of the tube allowing the sensor to receive reflected radiation.
FIGS. 5A, 5B, 6A, and 6B show an embodiment of UV-C emitting bulbs 108 positioned in a light fixture. The light fixture 122 may be mounted in a ceiling, such as a light fixture that is positioned between ceiling tiles. In this embodiment, fluorescent light bulbs 124 of a type that are generally in use are also present in the fixture. Bulbs 124 provide visible light for lighting the room and may be operated by a wall switch.
UV-C sensors 118 are present in the fixture 122. The sensors are preferred to be spaced apart from the UV-C emitting bulbs and mounted in the fixture so that they receive UV-C radiation that is reflected from surfaces in the room, and particularly surfaces that are below the bulbs 108, and the sensors do not receive material levels of direct UV-C radiation from the bulbs.
The embodiment of the light fixture shown in FIG. 5 and FIG. 6 uses louvers 120 as a safety device to prevent inadvertent discharge of UV-C radiation when people are in the room, motion is detected, or if objects are in the room that should not be present. The louvers also protect the UV-C bulbs, and help discourage service or replacement by unauthorized persons.
The covers or louvers 120 may be formed of an opaque material that prevents visible light and UV-C radiation from passing through. Alternatively, the covers or louvers may be formed of a material that is substantially transparent or translucent to visible light, but prevents or filters UV-C radiation from passing through the cover.
In one embodiment, the covers or louvers are movable and are movable in response to commands from the control system. Upon actuation of the device, the louvers are moved by actuators from the position (closed) shown in FIGS. 5A and 6A to the position (open) shown if FIGS. 5B and 6B to reveal the bulbs and permit treatment of the room. Upon completion, the actuators move the louvers to the enclosed position. The actuators may be driven by electric motors which rotate a drive train to rotate the louvers from the enclosed position into the open position and back to the closed position. Solenoids may also be used to move the louvers. A feedback device may be employed to provide open or closed louver status. A louver interlock mechanism may be included to prevent accidental activation of the lamps.
If coverage of the room cannot be accomplished by arrays of lamps positioned in the walls, the lamps or bulbs may be supplemented with lamps or bulbs positioned within the ceiling. It is preferred that the UV-C emitters are positioned overhead, so that the lamps are not easily reached by persons in the room. Further, positioning the lamps overhead gives the best chance of unobstructed emission of the UV-C radiation and reflection of the radiation, and particularly reflection from wall surfaces. The lamps or bulbs are spaced apart as necessary to achieve UV-C coverage that effectively kills pathogens in the room and within a reasonable time, such as less than about twenty (20) minutes for an operating suite. Portable lamps or bulbs may also be used, with the portable lamps positioned as required within the room. The position of the portable lamps may be dictated by the position of furniture or equipment that is located, or relocated, within the room.
In one embodiment, a control box 10 contains a controller. The controller is preferred to comprise components such as a microcontroller 32 and redundant control relays 28. Motion detectors 12, door interlocks 24 or door strike controls 35, louver status 34, and audible 20 and visible alarms 22 are preferred to be employed for safety. An embodiment of a control structure using a microcontroller is hereinafter described.
Referring now to FIG. 4, door interlocks 24 are shown. These interlocks are activated by the doors of the room in which the device is operating. The door interlocks are switches which disable the device if any one of the switches is opened, such as by opening the door. Door strike controls 35 would not allow the door to be opened while the device is activated. Optional motion detectors 12 are immediately monitored upon activation of the device and prior to powering of the ballasts 26 and the bulbs, by means of a relay 28. If the motion detectors sense motion at any time during the operation of the device, power to the ballasts and the bulbs is immediately disabled.
The device may be controlled by a programmable microcontroller. The controller may be a PIC Microcontroller 32 (PIC). The PIC may be contained in control box 10. PIC® Microcontrollers, available from Microchip Technology, Inc of Chandler, Ariz., may be used.
The PIC Microcontroller continuously receives a voltage input from sensors, such as sensors 18, 118, which receive reflected UV-C radiation, although sensors receiving direct radiation may also be monitored. Upon initiation of the device, the sensors continuously sense and measure the level of UV-C radiation which is reflected back to the device. It is preferred that the cumulative UV-C radiation emission is measured from initiation of the emission to termination for each of the sensors. Ideally, reflections from substantially all points in the room will be measured. Placement of the sensor and the number of sensors to be used will be determined by the size, architecture and contents of the room. For example, eight or more sensors that are strategically positioned may be used. Wireless remote UV-C sensors 35 may also be employed to monitor a specific area of concern.
If the device is ceiling mounted according to a preferred embodiment of the device, at least one sensor will typically be positioned in the ceiling to receive reflected radiation from the bulbs that are directed away from the ceiling. A sensor or sensors may be positioned in the lighting fixture, but is preferred that the sensor or sensor be positioned so as to receive reflected radiation without receiving UV-C radiation directly from the UV-C bulbs.
Each sensor converts the measurement of the level of radiation to a voltage output, which is transmitted to the microcontroller, such as the PIC. The PIC samples the voltage received at intervals and adds the cumulative total of the voltage received. When the PIC determines that the reflected UV-C radiation received by each and every sensor has reached the predetermined minimum cumulative total, the PIC causes the device to shut down, and a signal is given to the operator that the process has been completed. The PIC is programmable to measure voltage inputs as required by the particular application.
The PIC receives commands from a control, which may be a wireless remote control 30, or it maybe hardwired to the other operating components 33. The control may be mounted on a wall, but should be mounted outside of the enclosed area or room to be treated so that the control can be operated without exposing the operator to UV-C radiation.
A switch activates the remote control. Entry of a security code allows the operator to begin sending commands to the PIC. Commands include Activate, Shutdown, enter Sterilization Mode, or enter Sanitize Mode. The remote is in two-way communication with the device and displays data from the sensor array, time left to sterilize or sanitize the room, and in case of bulb failure, the status of all numbered bank of bulbs. If two-way communication with the remote is lost, the device shuts down.
The PIC monitors the motion detectors at least one minute prior to activation of the UV-C bulbs and continues to monitor the detectors during the cycle. The PIC performs calculations regarding bactericidal doses, stores cumulative dosing data, adjusts or causes allocation of UV-C emitter power levels and/or emissions as required, and conducts system checks to alert the operator of bulb failure. This is needed since an operator should not look at the bulbs to check for burned out bulbs or damaged banks. The PIC can be reprogrammed by attaching a personal computer via a data bus connection, thus allowing alteration to the algorithms to accommodate special circumstances.
An example of a protocol for using an embodiment of the device is described. An operator checks the room for occupants, then leaves the room. After securing the room, the operator enters into the control a security code or password, whereupon the operator is prompted to press an “on” switch on the control, activating the device. The audible voice alarms and the motion detectors activate and are preferred to stay on until the entire cycle has been complete. Should the device detect motion, the device automatically deactivates itself until the operator re-enters the room to clear the room, thus preventing the operator from re-activating the device and harming an occupant present in the room.
One or more motion detectors are monitored for a preset time, such as one minute, prior to opening the louvers and powering the UV-C bulbs, and then stay active until the cycle is complete, the bulbs are powered down and the louvers closed. The array of bulbs according to the embodiment shown in the drawings emits UV-C radiation downwardly to at a preferred minimum angle of 150 degrees, and more preferably, at substantially 180 degrees, from the array of bulbs, so that working and occupied surfaces that are below the array of bulbs and are within the enclosed area are exposed to UV-C radiation. As seen in FIG. 1, all furniture, fixtures and objects that are in a direct line with the bulbs 8 will receive direct radiation.
Sensors are positioned so as to not receive direct output from the germicidal lamps, thus measuring the dose of UV-C reflected back to the sensors. This data is fed into the microcontroller where it is integrated to compute cumulative exposure of UV-C reflected back from each sensor in the array.
In one embodiment, reflecting from the least reflective surface or direction the microcontroller calculates the time the device stays activated to allow an effective dose of UV-C to be emitted within the enclosed area. Several thousand measurements or “snapshots” may be taken for computation of the cumulative dosage.
Once sufficient time for a lethal dose of UV-C to be reflected back to the sensors has elapsed, and the minimum cumulative dosage corresponding to each sensor is received by the corresponding sensor, the device may power down the bulbs and sound an “all clear” alert to the operator. If the device uses louvers or similar movable covers for the fixture, then the louvers may move to a closed position that covers the UV-C emitters or bulbs.
Upon completion of the cycle, the device is preferred to have disinfected all the exposed surfaces within the room, including the primary shadows such as the back or wall side of rails, cabinets which are not against the wall, and tables. Surfaces not directly exposed to the UV-C radiation may be sterilized by UV-C radiation reflected from the walls and ceilings.
In most environments, there is a presence of what microbiology labs label as “wild spore forms” of bacteria. These bacteria are not known to cause human disease, and yet, are resistant to low doses of UV-C. The dual programming modes of one embodiment of the device allow treatment as required. One mode (Sanitize) kills all known pathogens and requires a lower exposure and thus shorter time. The other mode (Sterilize) kills all species of bacteria and requires greater cumulative doses and therefore more time.
Without adequate safety features, daily use of intense UV-C is dangerous and impractical. The device may have motion detectors which assure the room is vacant of personnel prior to activation. Once activated, the device shuts down instantly when motion occurs anywhere in the room being disinfected. If the device loses two-way communication with the control panel it also shuts down. In daily use, safety protocols commonly used in hospitals such as those in use for laser and x-ray devices may be implemented.
The device is able to sanitize or sterilize exposed surfaces in a room. It is able to do so safely, leave no residual toxins or radiation, and generates no adverse environmental side products. In addition, the device is able to notify the operator of the time required to perform this task and automatically shuts down upon completion of sterilization. The inventor has performed tests to prove the efficacy of the device, all of which have been successful. Reflectivity of some paints and other surfaces which absorb rather than reflect UV-C, requiring prolonged exposures of twenty minutes or greater. Specially reflective paints are preferred to be included in the system of area sterilization presented by this invention.
The estimated reflection from the wall in a typical hospital room was only 3%. Reflection below three percent is not desirable, since the increased exposure time required to achieve an effective dose may result in degradation of articles which are present in the room and which are exposed to direct UV-C radiation. A minimum of five (5%) percent reflectivity is desired. Through the use of paint or coating that produces a painted wall reflecting 50-85% of the UV-C, the efficiency of the device is increased, allowing for greatly decreased exposure times.
UV-C effectiveness depends primarily on the total dose delivered to the microorganisms and is often expressed as DUV=lt where DUV represents the total exposure or energy applied, l is the average irradiance in microwatts/cm2, and t is the exposure time in seconds. The survival fraction (S) of a microbial population exposed to UV-C is an exponential function of dose expressed by the equation: S=e−kD, In this equation, D means the total energy to which a microorganism is exposed and k represents a species-specific deactivation or kill rate constant. Values for the k constant have been measured for a vast array of microbial species. Thus, any modifications to the methods described which increase the intensity of UV-C shorten the required exposure time. The unique combination of highly reflective paints and other wall coverings with multiple UV-C emitters controlled as previously described potentially creates an effect wherein energy is added to the area nearly as fast or faster than it is being absorbed. This recurrent reflection effect boosts the total UV-C available to expose pathogens within the room in an accelerating, nonlinear fashion where the above formulas no longer apply. Sufficient UV-C intensity results in micro-steam bubbles within the nuclei of pathogens and almost instantaneous death by irreversible DNA damage.
It is preferred to have the walls of the room, and other painted surfaces in the room, covered with paint or a similar coating. The paint or coating should have UV-C reflectivity enhancing materials, which may be pigments, in the paint 40. The reflective particles or pigments may be colorants. In one embodiment, the coating includes particles of barium sulfate that will reflect the UV-C radiation. This coating may be transparent to the naked eye, and used to cover painted surfaces such as painted walls or cabinets. In another embodiment, aluminum oxide is used as a pigment that will enhance reflectivity of the UV-C radiation. It is preferred that the paint or coating not have titanium dioxide in a form that absorbs ultraviolet radiation. The paint or coating should be free of materials that are added to the paint or coating for the purpose of absorbing ultraviolet radiation. Reflective pigments such as aluminum oxide, silver oxide, or barium sulfate may be used in the paint or other coating.
In one embodiment of the device, which may be fixed to the building or portable, each sensor is associated with a bank of bulbs, and each bank of bulbs is powered by a variable output ballast. Each sensor converts the measurement of the level of reflected UV-C radiation to a voltage output, which is transmitted to the PIC. The PIC samples the voltage received at intervals and adds the cumulative total of the voltage received from each sensor. When the PIC determines that the reflected radiation received by a particular sensor is lower on average than the other sensors, the power from the variable ballast of the associated bulbs is increased. At the same time, the power from the ballast whose associated sensor is receiving the highest reflected dose is reduced in proportion. This protocol is repeated such that each sensor receives the required cumulative dosage at approximately the same time, while maintaining constant total ballast input power. This embodiment provides an optimum sterilization rate for a given input power and prevents repeated over dosing of some areas.
In an embodiment that is similar to the one described immediately above, the bulbs are UV-C emitting light emitting diode (LED) arrays that receive direct current from a pulse width modulated power supply. FIG. 7. A driver 36 modulates (such as a rapid on-off) the direct current applied to an array of LEDs 37. The frequency and duty-cycle of the pulse width modulation (PWM) can be independently varied by the PIC, so that the level of UV-C emission over a given period of time may be varied. There may be a plurality, or array, of drivers and a plurality of arrays of LEDs. When the PIC determines that the reflected UV-C radiation received by the sensors 18 is not in balance, the pulse width modulated radiation emissions are adjusted to achieve a more uniform reflected dose. This embodiment provides the optimum sterilization rate for a given input power and prevents repeated over dosing of areas. As with the other embodiments, when the predetermined level of radiation is achieved, power is terminated. The device may provide a signal to indicate that treatment is concluded.

## Claims

1. A method of disinfecting an enclosed area by use of ultraviolet radiation, comprising the steps of:
emitting ultraviolet-C radiation from a plurality of spaced apart locations in an enclosed area of a building;
receiving and measuring reflected ultraviolet-C radiation at a second plurality of spaced apart locations in the enclosed area of the building; and
continuing to emit ultraviolet-C radiation from a plurality of spaced apart locations in the enclosed area of the building until each of the second plurality of spaced apart locations receives a defined minimum dosage of ultraviolet-C radiation;
wherein at least one location from which ultraviolet-C radiation is emitted is mounted to the enclosed area of the building and is a fixture to the enclosed area of the building.

2. A method of disinfecting an enclosed area by use of ultraviolet radiation according to claim 1, wherein the dosage of ultraviolet-C radiation received at each of the second plurality of spaced apart locations is monitored by a controller, and the controller controls emission of the ultraviolet-C radiation from each of the spaced apart locations.

3. A method of disinfecting an enclosed area by use of ultraviolet radiation according to claim 1, wherein ultraviolet-C radiation is emitted from overhead.

4. A method of disinfecting an enclosed area by use of ultraviolet radiation according to claim 1, wherein ultraviolet-C radiation is emitted by light emitting diodes.

5. A method of disinfecting an enclosed area by use of ultraviolet radiation according to claim 1, further comprising the step of receiving ultraviolet-C radiation that is directly emitted.

6. A method of disinfecting an enclosed area by use of ultraviolet radiation according to claim 1, wherein each location of the plurality of spaced apart locations from which ultraviolet-C radiation is emitted is associated with a location of the second plurality of spaced apart locations at which ultraviolet-C radiation is received.

7. A method of disinfecting an enclosed area by use of ultraviolet radiation according to claim 1, wherein ultraviolet-C radiation emission is amplified by hyper-reflective wall coatings.

8. A method of disinfecting an enclosed area by use of ultraviolet radiation according to claim 1, further comprising the step of opening a cover to permit emission of ultraviolet-C radiation.

9. A method of disinfecting an enclosed area by use of ultraviolet radiation according to claim 1, further comprising the steps of opening a cover to permit emission of ultraviolet-C radiation and subsequently closing the cover.

10. A method of disinfecting an enclosed area by use of ultraviolet radiation, comprising:
emitting ultraviolet-C radiation from overhead of an enclosed area and toward a wall of the enclosed area; and
receiving and measuring reflected ultraviolet-C radiation that is reflected within the enclosed area at a plurality of spaced apart locations in the enclosed area of the building,
wherein the ultraviolet-C radiation reflected from the wall to said plurality of spaced apart locations in the enclosed area of the building sensors is measured, and emission of ultraviolet-C radiation after a predetermined accumulated dosage of radiation is received by each of said radiation sensors.

11. A method of disinfecting an enclosed area by use of ultraviolet radiation as describe in claim 10, wherein said ultraviolet-C radiation is emitted from a ceiling of the enclosed area.

12. A method of disinfecting an enclosed area by use of ultraviolet radiation as describe in claim 10, wherein said ultraviolet-C radiation is emitted from a ceiling of the enclosed area, and wherein reflected ultraviolet-C radiation is received at a location that is attached to the ceiling.

13. A method of disinfecting an enclosed area by use of ultraviolet radiation as describe in claim 10, wherein reflected ultraviolet-C radiation is received and measured at a location on an architectural partition of the enclosed area and ultraviolet-C radiation is received at a second location that is underneath equipment or furniture that is present in the enclosed area, and the second location is below a position of ultraviolet-C radiation emission.

14. A method of disinfecting an enclosed area by use of ultraviolet radiation as describe in claim 10, further comprising the step of emitting visible light from an ultraviolet-C emitter.

15. A method of disinfecting an enclosed area by use of ultraviolet radiation as described in claim 10, wherein the wall of the enclosed area is coated so as to reflect not less than five (5%) percent of the UV-C radiation directed at said wall.

16. A method of disinfecting an enclose area by use of ultraviolet radiation as describe in claim 10, wherein the emission of ultraviolet-C radiation is from a ceiling and from a wall of the enclosed area.

17. A method of disinfecting an enclosed area by use of ultraviolet radiation, as describe in claim 10, further comprising the steps of opening a cover to permit emission of ultraviolet-C radiation and subsequently closing the cover.

18. A method of disinfecting an enclosed area by use of ultraviolet radiation, as describe in claim 10, wherein the ultraviolet-C radiation is emitted from overhead and from a corner of the enclosed area.

19. A method of disinfecting an enclosed area by use of ultraviolet radiation, as describe in claim 10, wherein ultraviolet-C radiation is emitted from a corner of the enclosed area to direct UV-C radiation from overhead to a diagonally opposite corner of the enclosed area.

20. A method of disinfecting an enclosed area by use of ultraviolet radiation, as describe in claim 10, further comprising the step of emitting UV-C radiation from overhead and toward a second wall of the enclosed area.

21. A method of disinfecting an enclosed area by use of ultraviolet radiation, as describe in claim 10, wherein ultraviolet-C radiation is emitted to the entirety of the enclosed area from overhead.

22. A method of disinfecting an enclosed area by use of ultraviolet radiation, as describe in claim 10, wherein ultraviolet-C radiation is emitted from a plurality of spaced apart and overhead locations.

23. A method of disinfecting an enclosed area by use of ultraviolet radiation, as describe in claim 10, further comprising the step of receiving ultraviolet-C radiation that is directly emitted.