[Federal Register Volume 86, Number 174 (Monday, September 13, 2021)]
[Notices]
[Pages 50904-50907]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2021-19632]



[[Page 50904]]

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DEPARTMENT OF JUSTICE

Drug Enforcement Administration

[Docket No. DEA-898]


Bulk Manufacturer of Controlled Substances Application: Cayman 
Chemical Company

AGENCY: Drug Enforcement Administration, Justice.

ACTION: Notice of application.

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SUMMARY: Cayman Chemical Company, has applied to be registered as a 
bulk manufacturer of basic class(es) of controlled substance(s). Refer 
to Supplementary Information listed below for further drug information.

DATES: Registered bulk manufacturers of the affected basic class(es), 
and applicants therefore, may file written comments on or objections to 
the issuance of the proposed registration on or before November 12, 
2021. Such persons may also file a written request for a hearing on the 
application on or before November 12, 2021.

ADDRESSES: Written comments should be sent to: Drug Enforcement 
Administration, Attention: DEA Federal Register Representative/DPW, 
8701 Morrissette Drive, Springfield, Virginia 22152.

SUPPLEMENTARY INFORMATION: In accordance with 21 CFR 1301.33(a), this 
is notice that on July 15, 2021, Cayman Chemical Company, 1180 East 
Ellsworth Road, Ann Arbor, Michigan 48108-2419, applied to be 
registered as a bulk manufacturer of the following basic class(es) of 
controlled substance(s):

------------------------------------------------------------------------
           Controlled substance               Drug code       Schedule
------------------------------------------------------------------------
3-Fluoro-N-methylcathinone (3-FMC).......            1233  I
Cathinone................................            1235  I
Methcathinone............................            1237  I
4-Fluoro-N-methylcathinone (4-FMC).......            1238  I
Pentedrone ([alpha]-                                 1246  I
 methylaminovalerophenone).
Mephedrone (4-Methyl-N-methylcathinone)..            1248  I
4-Methyl-N-ethylcathinone (4-MEC)........            1249  I
Naphyrone................................            1258  I
N-Ethylamphetamine.......................            1475  I
N,N-Dimethylamphetamine..................            1480  I
Fenethylline.............................            1503  I
Aminorex.................................            1585  I
4-Methylaminorex (cis isomer)............            1590  I
Gamma Hydroxybutyric Acid................            2010  I
Methaqualone.............................            2565  I
Mecloqualone.............................            2572  I
JWH-250 (1-Pentyl-3-(2-                              6250  I
 methoxyphenylacetyl) indole).
SR-18 (Also known as RCS-8) (1-                      7008  I
 Cyclohexylethyl-3-(2-
 methoxyphenylacetyl) indole).
ADB-FUBINACA (n-(1-amino-3,3-dimethyl-1-             7010  I
 oxobutan-2-yl)-1-(4-fluorobenzyl)-1H-
 indazole-3-carboxamide).
5-Flouro-UR-144 and XLR11 [1-(5-Fluoro-              7011  I
 pentyl)1H-indol-3-yl](2,2,3,3-
 tetramethylcyclopropyl)methanone.
AB-FUBINACA (N-(1-amino-3-methyl-1-                  7012  I
 oxobutan-2-yl)-1-(4-fluorobenzyl)-1H-
 indazole-3-carboxamide).
(1-(4-Fluorobenzyl)-1H-indol-3-                      7014  I
 yl)(2,2,3,3tetramethylcyclopropyl)methan
 one.
JWH-019 (1-Hexyl-3-(1-naphthoyl)indole)..            7019  I
MDMB-FUBINACA (Methyl 2-(1-4-                        7020  I
 fluorobenzyl)-1H-indazole-3-carboxamido)-
 3,3-dimethylbutanoate).
2-(1-(4-fluorobenzyl)-1Hindazole-3-                  7021  I
 carboxamido)-3- methylbutanoate.
AB-PINACA (N-(1-amino-3-methyl-1-oxobutan-           7023  I
 2-yl)-1-pentyl-1H-indazole-3-
 carboxamide).
THJ-2201 [1-(5-fluoropentyl)-1H-indazol-3-           7024  I
 yl](naphthalen-1-yl)methanone.
5F-AB-PINACA (N-(1-amino-3-methyl-1-                 7025  I
 oxobutan-2-yl)1-(5-fluoropentyl)-1 H-
 indazole-3-carboxamide).
AB-CHMINACA (N-(1-amino-3-methyl-1-                  7031  I
 oxobutan-2-yl)-1-(cyclohexylmethyl)-1H-
 indazole-3-carboxamide.
MAB-CHMINACA (N-(1-amino-3,3dimethyl-1-              7032  I
 oxobutan-2-yl)-1-(cyclohexylmethyl)-1H-
 indazole-3-carboxamide).
5F-AMB (Methyl 2-(1-(5-fluoropentyl)-1H-             7033  I
 indazola-3-carboxamido)-3-
 methylbutanoate).
5F-ADB; 5F-MDMB-PINACA (Methyl 2-(1-                 7034  I
 (5fluoropentyl)-1H-indazole-3-
 carboxamido)-3,3dimethylbutanoate).
ADB-PINACA (N-(1-amino-3,3-dimethyl-1-               7035  I
 oxobutan-2-yl)-1-pentyl-1H-indazole-3-
 carboxamide).
Ethyl 2-(1-(5-fluoropentyl)-1H-indazole-3-           7036  I
 carboxamido)3,3-dimethylbutanoate.
Methyl 2-(1-(5-fluoropentyl)-1H-indole-3-            7041  I
 carboxamido)3,3-dimethylbutanoate.
MDMB-CHMICA, MMB-CHMINACA (Methyl 2-(1-              7042  I
 (cyclohenxylmethyl)-1H-indole-3-
 carboxamido)-3,3-dimethylbutanote)-.
MMB-CHMICA, AMB-CHMICA (methyl 2-                    7044  I
 (1(cyclohexylmethyl)-1 H-indole-3-
 carboxamido)-3methylbutanoate).
N-(Adamantan-1-yl)-1-(4-fluorobenzyl)-1H-            7047  I
 indazole-3carboxamide.
APINACA and AKB48 N-(1-Adamantyl)-1-                 7048  I
 pentyl-1H-indazole-3-carboxamide.
5F-APINACA, 5F-AKB48 (N-(adamantan-1-yl)-            7049  I
 1-(5fluoropentyl)-1H-indazole-3-
 carboxamide).
JWH-081 (1-Pentyl-3-(1-(4-                           7081  I
 methoxynaphthoyl) indole).
1-(5-Fluoropentyl)-N-(2-phenylpropan-2-              7083  I
 yl)-1H-indazole3-carboxamide.
5F-CUMYL-P7AICA (1-(5-fluoropentyl)-N-               7085  I
 (2phenylpropan-2-yl)-1 H-pyrrolo[2,3-
 b]pyridine-3carboxamide).
4-CN-CUMYL-BUTINACA (1-(4-cyanobutyl)-N-             7089  I
 (2phenylpropan-2-yl)-1 H-indazole-3-
 carboxamide).
SR-19 (Also known as RCS-4) (1-Pentyl-3-             7104  I
 [(4-methoxy)-benzoyl] indole.
JWH-018 (also known as AM678) (1-Pentyl-3-           7118  I
 (1-naphthoyl)indole).
JWH-122 (1-Pentyl-3-(4-methyl-1-                     7122  I
 naphthoyl) indole).
UR-144 (1-Pentyl-1H-indol-3-yl)(2,2,3,3-             7144  I
 tetramethylcyclopropyl)methanone.
JWH-073 (1-Butyl-3-(1-naphthoyl)indole)..            7173  I
JWH-200 (1-[2-(4-Morpholinyl)ethyl]-3-(1-            7200  I
 naphthoyl)indole).
AM2201 (1-(5-Fluoropentyl)-3-(1-                     7201  I
 naphthoyl) indole).
JWH-203 (1-Pentyl-3-(2-                              7203  I
 chlorophenylacetyl) indole).
NM2201; CBL2201 (Naphthalen-1-yl 1-(5-               7221  I
 fluoropentyl)1 H-indole-3-carboxylate).
PB-22 (Quinolin-8-yl 1-pentyl-1H-indole-3-           7222  I
 carboxylate).
5F-PB-22 (Quinolin-8-yl 1-(5-                        7225  I
 fluoropentyl)-1H-indole-3-carboxylate).
4-methyl-alpha-ethylaminopentiophenone (4-           7245  I
 MEAP).

[[Page 50905]]

 
N-ethylhexedrone.........................            7246  I
Alpha-ethyltryptamine....................            7249  I
Ibogaine.................................            7260  I
CP-47,497 (5-(1,1-Dimethylheptyl)-2-                 7297  I
 [(1R,3S)-3-hydroxycyclohexyl-phenol).
CP-47,497 C8 Homologue (5-(1,1-                      7298  I
 Dimethyloctyl)-2-[(1R,3S)3-
 hydroxycyclohexyl-phenol).
Lysergic acid diethylamide...............            7315  I
2,5-Dimethoxy-4-(n)-                                 7348  I
 propylthiophenethylamine (2C-T-7).
Marihuana................................            7360  I
Tetrahydrocannabinols....................            7370  I
Mescaline................................            7381  I
2-(4-Ethylthio-2,5-dimethoxyphenyl)                  7385  I
 ethanamine (2C-T-2 ).
3,4,5-Trimethoxyamphetamine..............            7390  I
4-Bromo-2,5-dimethoxyamphetamine.........            7391  I
4-Bromo-2,5-dimethoxyphenethylamine......            7392  I
4-Methyl-2,5-dimethoxyamphetamine........            7395  I
2,5-Dimethoxyamphetamine.................            7396  I
JWH-398 (1-Pentyl-3-(4-chloro-1-                     7398  I
 naphthoyl) indole).
2,5-Dimethoxy-4-ethylamphetamine.........            7399  I
3,4-Methylenedioxyamphetamine............            7400  I
5-Methoxy-3,4-methylenedioxyamphetamine..            7401  I
N-Hydroxy-3,4-methylenedioxyamphetamine..            7402  I
3,4-Methylenedioxy-N-ethylamphetamine....            7404  I
3,4-Methylenedioxymethamphetamine........            7405  I
4-Methoxyamphetamine.....................            7411  I
5-Methoxy-N-N-dimethyltryptamine.........            7431  I
Alpha-methyltryptamine...................            7432  I
Diethyltryptamine........................            7434  I
Dimethyltryptamine.......................            7435  I
Psilocybin...............................            7437  I
Psilocyn.................................            7438  I
5-Methoxy-N,N-diisopropyltryptamine......            7439  I
4-chloro-alpha-pyrrolidinovalerophenone              7443  I
 (4-chloro-a-PVP).
4'-methyl-alpha-pyrrolidinohexiophenone              7446  I
 (MPHP).
N-Ethyl-1-phenylcyclohexylamine..........            7455  I
1-(1-Phenylcyclohexyl)pyrrolidine........            7458  I
1-[1-(2-Thienyl)cyclohexyl]piperidine....            7470  I
1-[1-(2-Thienyl)cyclohexyl]pyrrolidine...            7473  I
N-Benzylpiperazine.......................            7493  I
2-(2,5-Dimethoxy-4-methylphenyl)                     7508  I
 ethanamine (2C-D).
2-(2,5-Dimethoxy-4-ethylphenyl)                      7509  I
 ethanamine (2C-E ).
2-(2,5-Dimethoxyphenyl) ethanamine (2C-H)            7517  I
2-(4-iodo-2,5-dimethoxyphenyl) ethanamine            7518  I
 (2C-I).
2-(4-Chloro-2,5-dimethoxyphenyl)                     7519  I
 ethanamine (2C-C).
2-(2,5-Dimethoxy-4-nitro-phenyl)                     7521  I
 ethanamine (2C-N).
2-(2,5-Dimethoxy-4-(n)-propylphenyl)                 7524  I
 ethanamine (2C-P).
2-(4-Isopropylthio)-2,5-dimethoxyphenyl)             7532  I
 ethanamine (2C-T-4 ).
MDPV (3,4-Methylenedioxypyrovalerone)....            7535  I
2-(4-bromo-2,5-dimethoxyphenyl)-N-(2-                7536  I
 methoxybenzyl) ethanamine (25B-NBOMe).
2-(4-chloro-2,5-dimethoxyphenyl)-N-(2-               7537  I
 methoxybenzyl) ethanamine (25C-NBOMe).
2-(4-iodo-2,5-dimethoxyphenyl)-N-(2-                 7538  I
 methoxybenzyl) ethanamine (25I-NBOMe).
Methylone (3,4-Methylenedioxy-N-                     7540  I
 methylcathinone).
Butylone.................................            7541  I
Pentylone................................            7542  I
alpha-pyrrolidinohexanophenone (a-PHP)...            7544  I
alpha-pyrrolidinopentiophenone ([alpha]-             7545  I
 PVP).
alpha-pyrrolidinobutiophenone ([alpha]-              7546  I
 PBP).
Ethylone.................................            7547  I
alpha-pyrrolidinoheptaphenone (PV8)......            7548  I
AM-694 (1-(5-Fluoropentyl)-3-(2-                     7694  I
 iodobenzoyl) indole).
Acetyldihydrocodeine.....................            9051  I
Benzylmorphine...........................            9052  I
Codeine-N-oxide..........................            9053  I
Desomorphine.............................            9055  I
Etorphine (except HCl)...................            9056  I
Codeine methylbromide....................            9070  I
Brorphine................................            9098  I
Dihydromorphine..........................            9145  I
Difenoxin................................            9168  I
Heroin...................................            9200  I
Hydromorphinol...........................            9301  I
Morphine-N-oxide.........................            9307  I
Normorphine..............................            9313  I
U-47700 (3,4-dichloro-N-[2-                          9547  I
 (dimethylamino)cyclohexyl]-N-
 methylbenzamide).
MT-45 (1-cyclohexyl-4-(1,2-                          9560  I
 diphenylethyl)piperazine)).

[[Page 50906]]

 
Clonitazene..............................            9612  I
Isotonitazene (N,N-diethyl-2-(2-(4                   9614  I
 isopropoxybenzyl)-5-nitronitro-1H-
 benzimidazol-1-yl)ethan-1-amine).
Etonitazene..............................            9624  I
Ketobemidone.............................            9628  I
Trimeperidine............................            9646  I
Tilidine.................................            9750  I
Acryl fentanyl (N-(1-phenethylpiperidin-4-           9811  I
 yl)-N-phenylacrylamide).
Para-Fluorofentanyl......................            9812  I
3-Methylfentanyl.........................            9813  I
Alpha-methylfentanyl.....................            9814  I
Acetyl-alpha-methylfentanyl..............            9815  I
N-(2-fluorophenyl)-N-(1-                             9816  I
 phenethylpiperidin-4-yl)propionamide.
Para-Methylfentanyl (N-(4-methylphenyl)-N-           9817  I
 (1phenethylpiperidin-4-yl)propionamide;
 also known as 4methylfentanyl).
4'-Methyl acetyl fentanyl (N-(1-                     9819  I
 (4methylphenethyl)piperidin-4-yl)-N-
 phenylacetamide).
ortho-Methyl methoxyacetyl fentanyl (2-              9820  I
 methoxy-N-(2methylphenyl)-N-(1-
 phenethylpiperidin-4-yl)acetamide).
Acetyl Fentanyl (N-(1-phenethylpiperidin-            9821  I
 4-yl)-N-phenylacetamide).
Butyryl Fentanyl.........................            9822  I
Para-fluorobutyryl fentanyl..............            9823  I
4-Fluoroisobutyryl fentanyl (N-(4-                   9824  I
 fluorophenyl)-N-(1phenethylpiperidin-4-
 yl)isobutyramide).
2-methoxy-N-(1-phenethylpiperidin-4-yl)-N-           9825  I
 phenylacetamide.
Para-chloroisobutyryl fentanyl...........            9826  I
Isobutyryl fentanyl......................            9827  I
Beta-hydroxyfentanyl.....................            9830  I
Beta-hydroxy-3-methylfentanyl............            9831  I
Alpha-methylthiofentanyl.................            9832  I
3-Methylthiofentanyl.....................            9833  I
Furanyl fentanyl (N-(1-phenethylpiperidin-           9834  I
 4-yl)-N-phenylfuran-2-carboxamide).
Thiofentanyl.............................            9835  I
Beta-hydroxythiofentanyl.................            9836  I
Para-methoxybutyryl fentanyl.............            9837  I
Ocfentanil...............................            9838  I
Thiofuranyl fentanyl (N-(1-                          9839  I
 phenethylpiperidin-4-yl)-
 Nphenylthiophene-2-carboxamide; also
 known as 2thiofuranyl fentanyl;
 thiophene fentanyl).
Valeryl fentanyl.........................            9840  I
Phenyl fentanyl (N-(1-phenethylpiperidin-            9841  I
 4-yl)-Nphenylbenzamide; also known as
 benzoyl fentanyl).
beta'-Phenyl fentanyl (N-(1-                         9842  I
 phenethylpiperidin-4-yl)-
 N,3diphenylpropanamide; also known as
 [beta]'-phenyl fentanyl; 3-
 phenylpropanoyl fentanyl).
N-(1-phenethylpiperidin-4-yl)-N-                     9843  I
 phenyltetrahydrofuran2-carboxamide.
Crotonyl fentanyl ((E)-N-(1-                         9844  I
 phenethylpiperidin-4-yl)-Nphenylbut-2-
 enamide).
Cyclopropyl Fentanyl.....................            9845  I
ortho-Fluorobutyryl fentanyl (N-(2-                  9846  I
 fluorophenyl)-N-(1phenethylpiperidin-4-
 yl)butyramide; also known as
 2fluorobutyryl fentanyl).
Cyclopentyl fentanyl.....................            9847  I
ortho-Methyl acetylfentanyl (N-(2-                   9848  I
 methylphenyl)-N-(1phenethylpiperidin-4-
 yl)acetamide; also known as 2methyl
 acetylfentanyl).
Fentanyl related-substances as defined in            9850  I
 21 CFR 1308.11(h).
Fentanyl carbamate (ethyl (1-                        9851  I
 phenethylpiperidin-
 4yl)(phenyl)carbamate).
ortho-Fluoroacryl fentanyl (N-(2-                    9852  I
 fluorophenyl)-N-(1phenethylpiperidin-4-
 yl)acrylamide).
ortho-Fluoroisobutyryl fentanyl (N-(2-               9853  I
 fluorophenyl)-N-(1phenethylpiperidin-4-
 yl)isobutyramide).
Para-Fluoro furanyl fentanyl (N-(4-                  9854  I
 fluorophenyl)-N-(1phenethylpiperidin-4-
 yl)furan-2-carboxamide).
2'-Fluoro ortho-fluorofentanyl (N-(1-                9855  I
 (2fluorophenethyl)piperidin-4-yl)-N-
 (2fluorophenyl)propionamide; also known
 as 2'-fluoro 2fluorofentanyl).
beta-Methyl fentanyl (N-phenyl-N-(1-                 9856  I
 (2phenylpropyl)piperidin-4-
 yl)propionamide; also known as [beta]-
 methyl fentanyl).
Amphetamine..............................            1100  II
Methamphetamine..........................            1105  II
Lisdexamfetamine.........................            1205  II
Phenmetrazine............................            1631  II
Methylphenidate..........................            1724  II
Amobarbital..............................            2125  II
Pentobarbital............................            2270  II
Secobarbital.............................            2315  II
Glutethimide.............................            2550  II
1-Phenylcyclohexylamine..................            7460  II
Phencyclidine............................            7471  II
4-Anilino-N-phenethyl-4-piperidine (ANPP)            8333  II
Norfentanyl..............................            8366  II
Phenylacetone............................            8501  II
1-Piperidinocyclohexanecarbonitrile......            8603  II
Cocaine..................................            9041  II
Codeine..................................            9050  II
Etorphine HCl............................            9059  II
Dihydrocodeine...........................            9120  II
Oxycodone................................            9143  II
Hydromorphone............................            9150  II

[[Page 50907]]

 
Ecgonine.................................            9180  II
Ethylmorphine............................            9190  II
Hydrocodone..............................            9193  II
Levomethorphan...........................            9210  II
Levorphanol..............................            9220  II
Isomethadone.............................            9226  II
Meperidine...............................            9230  II
Meperidine intermediate-B................            9233  II
Oliriceridine............................            9245  II
Methadone................................            9250  II
Dextropropoxyphene, bulk (non-dosage                 9273  II
 forms).
Morphine.................................            9300  II
Thebaine.................................            9333  II
Oxymorphone..............................            9652  II
Noroxymorphone...........................            9668  II
Thiafentanil.............................            9729  II
Alfentanil...............................            9737  II
Remifentanil.............................            9739  II
Sufentanil...............................            9740  II
Carfentanil..............................            9743  II
Tapentadol...............................            9780  II
Fentanyl.................................            9801  II
------------------------------------------------------------------------

    The company plans to bulk manufacture the listed controlled 
substances for internal use or for sale to its customers. In reference 
to dug codes 7360 (Marihuana), and 7370 (Tetrahydrocannabinols), the 
company plans to bulk manufacture these drugs as synthetic. No other 
activities for these drug codes are authorized for this registration.

Brian S. Besser,
Acting Assistant Administrator.
[FR Doc. 2021-19632 Filed 9-10-21; 8:45 am]
BILLING CODE P